Experimental transclival exposure and repair of the abducens nerve in cats.
Operations were carried out on eight cats using a transcervical, transclival approach to expose the sixth cranial nerve just beside the basilar artery. In one case 5 mm of the nerve were resected; three months later no reinnervation was seen. In another cat the nerve ends were merely adapted, and good regeneration was seen despite slight neuroma formation. In a third case TabotampR and Aron-Alpha R were used to repair the skull base; this resulted in a neuroma and in atrophy of the sixth cranial nerve with scar adhesions rendering regeneration impossible. In five cases the transsected nerves were glued together with a fibrin adhesive, with excellent results: very good regeneration and reinnervation occurred within three months with ideal parallel alignment of the nerve fibres at the site of the lesion.
D000010:Abducens Nerve / Q000473:pathology / Q000601:surgery*; D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage; D002415:Cats; D003388:Cranial Fossa, Posterior; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage; D008866:Microsurgery; D009416:Nerve Regeneration / Q000187:drug effects; D013917:Thrombin / Q000008:administration & dosage
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin