[Relation between the modulating effect of estradiol on the secretion of the pituitary luteinizing hormone and calcium ions in ovariectomized animals].
The effect of verapamil, the blocker of calcium channels, on estradiol modulation of the LH-RH effect on the secretion of the luteinizing hormone was studied in experiments on ovariectomized rats. It was shown that verapamil influenced neither the basal nor the LH-RH activated secretion of the hormone from the pituitary gland. However verapamil inhibited the effect of estradiol increasing the secretory response to LH-RH. Hence, the modulating effect of estradiol on the secretion of the luteinizing hormone depended on the transport of extracellular calcium into hypophyseal cells.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004958:Estradiol / Q000502:physiology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000378:metabolism*; D010052:Ovariectomy; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
D007473:Ion Channels; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D014700:Verapamil; D002118:Calcium
Zavisimost' moduliruiushchego deĭstviia éstradiola na sekretsiiu liuteiniziruiushchego gormona gipofizom ot ionov kal'tsiia u ovariéktomirovannykh zhivotnykh.