CA-125 in gynecological malignancies.
CA-125 is an antigenic determinant that can be demonstrated in the majority of epithelial ovarian carcinomas. It can be measured in the serum with a radioimmunoassay by means of a monoclonal antibody. The tumor marker has a low specificity but high sensitivity for ovarian cancer, especially for serous cystadenocarcinoma. In our investigation we were interested in particular in the correlation between CA-125 and the histological findings at second-look operation. In 22 patients, second-look was performed after 6 cycles of chemotherapy, in 16 patients active tumor was demonstrated. In 6 patients with negative CA-125 values, residual tumor less than 1 cm was demonstrated. In order to verify a complete remission, a second-look operation has to be performed. No false-positive CA-125 levels were found. In all patients with elevated CA-125 serum values, residual tumor was histologically confirmed at second look.
D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D001943:Breast Neoplasms / Q000276:immunology; D003536:Cystadenocarcinoma / Q000276:immunology*; D000939:Epitopes / Q000032:analysis*; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology / Q000601:surgery; D011247:Pregnancy; D012086:Reoperation
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D000939:Epitopes