[The glycosaminoglycan-glycanohydrolase system in the renal tissue of Brattleboro rats with a hereditary defect in antidiuretic hormone synthesis].
Glycosaminoglycan (GAG) content in the kidney of homo (DI) Brattleboro rats was shown to be minimal whereas the activity of glycanohydrolases (GH) in the papilla of diabetic rats was comparatively high. Injection of the antidiuretic hormone (ADH) increased the GH in the renal papillae of both the DI and HZ (heterozygous) rats. Disappearance of the beta-glucuronidase staining occurred in the collecting tubule's epithelial cells under the effect of adiuretin--SD and water deprivation for 2 days. The activation and redistribution of the GH under the ADH influence and the role of GAG and GH in the mechanism of ADH action, were discussed.
D000818:Animals; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000494:pharmacology; D006579:Heterozygote; D006651:Histocytochemistry; D006720:Homozygote; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology; D051381:Rats; D011910:Rats, Brattleboro / Q000378:metabolism*; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains / Q000378:metabolism*; D013577:Syndrome; D014667:Vasopressins / Q000172:deficiency* / Q000494:pharmacology
D006025:Glycosaminoglycans; D010909:Pituitary Hormones, Posterior; D014667:Vasopressins; D006026:Glycoside Hydrolases; D005966:Glucuronidase
Sistema glikozaminoglikany-glikanogidrolazy v pochechnoĭ tkani krys Brattlboro s nasledstvennym defektom sinteza antidiureticheskogo gormona.