title: Intracellular calcium-binding proteins: structure and possible functions.
abstract: The target proteins for calcium, when it acts as a second messenger, are a group of intracellular, specific calcium-binding proteins that contain EF-hand structures. Calmodulin regulates a number of Ca2+-dependent processes and is present in all eukaryotic cells. Parvalbumin, the S-100 proteins, two vitamin D-dependent Ca2+-binding proteins, and two tumor-associated proteins are present only in a few tissues and are there in distinct cell types serving more specific functions such as Ca2+-buffering or Ca2+-transport. The properties, distribution, and possible roles of these calcium-binding proteins in muscle, brain, and tumor cells are compared.
mesh_terms: D002135:Calcium-Binding Proteins / Q000032:analysis*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D006651:Histocytochemistry; D006801:Humans; D009132:Muscles / Q000032:analysis; D009474:Neurons / Q000032:analysis; D010320:Parvalbumins / Q000032:analysis; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D002135:Calcium-Binding Proteins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D009418:S100 Proteins