title: Disturbances of platelet function in patients with multiple myeloma.
abstract: Coagulation disturbances in patients with multiple myeloma are presented. Platelet disfunction was especially observed, but only in patients with marked hyperproteinemia and a high level of immunoglobulins in plasma, whereas normal adhesion and aggregation were noticed in 3 out of 17 patients without protein disturbances. Chemotherapy as well as plasma exchange caused not only a decrease of the paraprotein level in plasma, but also a normalization of the failure previously observed in platelet function. Our experiments confirm the opinion that protein M in plasma is responsible for the disturbances observed in multiple myeloma.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy; D009194:Myeloma Proteins / Q000097:blood; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D007074:Immunoglobulin G; D009194:Myeloma Proteins