[Interferon induction via peroral administration of high-molecular polynucleotides].
High molecular polynucleotides, poly(I).poly(C) and poly(G).poly(C), incorporated into liposomes may be used for serum interferon induction when administered orally. Titres of interferon induced by this method are sufficiently high (320-640 units/ml) and close to those induced by the same preparations administered parenterally (640-1280 units/ml). The use of liposomal polynucleotides results in prolonged (up to 24 hours) circulation of interferon in the blood of mice at a sufficiently high level. Liposomal polynucleotides are low-toxic upon oral intake. The liposome-polynucleotide complex is sufficiently stable on storage, and retains the interferon-inducing activity, if given orally, after 6 months of storage at 4 degrees C in the liquid form.
D000284:Administration, Oral; D000818:Animals; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D007372:Interferons / Q000097:blood; D008081:Liposomes / Q000008:administration & dosage; D051379:Mice; D008970:Molecular Weight; D011066:Poly C / Q000008:administration & dosage / Q000494:pharmacology; D011068:Poly G / Q000008:administration & dosage / Q000494:pharmacology; D011070:Poly I-C / Q000008:administration & dosage / Q000494:pharmacology; D011119:Polynucleotides / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D007369:Interferon Inducers; D008081:Liposomes; D011119:Polynucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D007372:Interferons; D011070:Poly I-C
Induktsiia interferona pri peroral'nym vvedenii vysokomolekuliarnykh polinukleotidov.