The T11(3) epitope of the CD2 molecule, sheep erythrocytes, and the alternative T-cell activation pathway.
In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D000939:Epitopes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D000939:Epitopes