title: Recent applications of immunoperoxidase histochemistry in human neuro-oncology. An update.
abstract: In this review, we describe some of the most commonly used antibodies and discuss their immunohistochemical applications to human neuro-oncology. We stress the importance of determining the spectrum of antibody immunoreactivity in a wide panel of normal, reactive, and neoplastic tissues, and the caution with which immunopositivity needs to be interpreted in atypical and aberrant cases. Whether the detection of a well-characterized, cell-type-specific marker in a tumor reflects histogenesis or solely differentiation potential is discussed in several examples.
mesh_terms: D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D019393:Arrestin; D001973:Bromodeoxyuridine; D002256:Carbonic Anhydrases / Q000032:analysis; D005136:Eye Proteins / Q000032:analysis; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007382:Intermediate Filaments / Q000032:analysis; D007633:Keratins / Q000032:analysis; D037102:Lectins / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis; D018396:Mucin-1; D004676:Myelin Basic Protein / Q000032:analysis; D009185:Myelin Proteins / Q000032:analysis; D018992:Myelin-Associated Glycoprotein; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D037121:Plant Lectins; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D019393:Arrestin; D005136:Eye Proteins; D005904:Glial Fibrillary Acidic Protein; D037102:Lectins; D008565:Membrane Proteins; D018396:Mucin-1; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D037121:Plant Lectins; D009418:S100 Proteins; C036850:Ulex europaeus lectins; D014746:Vimentin; D014841:von Willebrand Factor; D007633:Keratins; D005169:Factor VIII; D002256:Carbonic Anhydrases; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine