Interferon inhibits the growth of Legionella micdadei in mouse L cells.
The intracellular growth of Legionella micdadei was inhibited in mouse L cells treated with interferon (IFN). This IFN-mediated restriction was dose-dependent and required preincubation of the L cells with high doses of IFN (1,000 U/ml) for maximal inhibition. Incubation of L. micdadei with IFN alone had no detectable effect on growth of the bacteria. The IFN-mediated growth restriction was not dependent upon tryptophan concentration in the culture medium.
D000818:Animals; D003470:Culture Media; D003588:Cytopathogenic Effect, Viral; D004305:Dose-Response Relationship, Drug; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells / Q000382:microbiology; D007875:Legionella / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D014364:Tryptophan / Q000494:pharmacology
D003470:Culture Media; D014364:Tryptophan; D007372:Interferons