Normal and malignant neural cells: a comprehensive survey of human and murine nervous system markers.
Tumor-associated neural markers are finding increased application in diagnostic histopathology and in the development of brain tumor therapy. The major cell-type-specific markers and monoclonal antibodies that identify murine and human neural cells are reviewed in this study. Monoclonal antibodies, raised against fetal and adult neural tissue, neuroectodermal tumor tissue, or cell line immunogens which recognize epitopes on brain tumors are comprehensively described including antigens common to the nervous, hematopoietic, and immune systems. The clinical application of neural cell markers and monoclonal antibodies for the diagnosis, localization, and treatment of neuroectodermal tumors is reviewed.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D001253:Astrocytes / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005910:Glioma / Q000276:immunology; D006413:Hematopoietic System / Q000276:immunology; D006801:Humans; D006825:Hybridomas / Q000378:metabolism; D007107:Immune System / Q000276:immunology; D007382:Intermediate Filaments / Q000276:immunology; D007457:Iodine Radioisotopes; D051379:Mice; D009380:Neoplasms, Nerve Tissue / Q000175:diagnosis / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology; D009447:Neuroblastoma / Q000175:diagnosis; D009474:Neurons / Q000276:immunology* / Q000503:physiopathology; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D009418:S100 Proteins / Q000276:immunology; D018800:Thy-1 Antigens
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000939:Epitopes; D007457:Iodine Radioisotopes; D009419:Nerve Tissue Proteins; D009418:S100 Proteins; D018800:Thy-1 Antigens; D010751:Phosphopyruvate Hydratase