[Effect of vinblastine on experimental stomach carcinogenesis].
The experiments on inbred male rats have been carried out to estimate the effect of parenteral vinblastine, an inhibitor of catecholamine axoplasmatic transport, on gastric tumour growth induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) added to drinking water. The maximum tolerance dose of vinblastine was determined in subchronic experiments on 30 rats (0.25 mg/kg subcutaneously, once per week). Chronic experiments with combined introductions of MNNG and vinblastine were performed on 70 rats. Vinblastine was shown to inhibit carcinogenesis on "intestinization" stake and to decrease three-fold the incidence of gastric adenocarcinomas. Vinblastine-induced changes in the behaviour of animals reflect the decreased activity of central adrenergic processes. The role of catecholamines in the mechanisms of specific action of chemical carcinogens is discussed.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D008769:Methylnitronitrosoguanidine; D014747:Vinblastine
O deĭstvii vinblastina na éksperimental'nyĭ gastrokantserogenez.