title: High protection of animals lethally infected with influenza virus by aprotinin-rimantadine combination.
abstract: The successful therapeutic synergism of aprotinin and rimantadine, which are known to attack different viral targets, was demonstrated in influenza-virus-infected animals. Combined treatment with these drugs of mice infected with a highly lethal dose of mouse-adapted influenza virus prevented the development of fatal haemorrhagic pneumonia and protected about 75% of animals; whereas the separate administration of aprotinin and rimantadine induced 35% and 15% protection, respectively.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations; D004357:Drug Synergism; D009980:Influenza A virus / Q000187:drug effects; D008168:Lung / Q000473:pathology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D012299:Rimantadine / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D012299:Rimantadine; D007611:Aprotinin; D000218:Adamantane