[Detection of factor XIII deficiency in acute leukemia with resonance thrombography].
In 16 patients affected with acute leukemia (7 patients with acute lymphatic leukemia and 9 patients with acute myeloid leukemia) the resonance thrombogramme was recorded during cytostatic induction therapy, coagulation factor XIII (subunit XIII-A, XIII-S) and further hemostasiological parameters were determined. Subunit XIII-A was lowered to 36%, subunit XIII-S to 65% and the fibrin formation time of the resonance thrombogramme was extended to 9 minutes. There exists a negative correlation between component XIII-A and fibrin formation time r = -0.48 (p less than 0.01). The influence exerted by diminishing factor XIII and fibrin(ogen) splitting products on the fibrin formation time was investigated in in-vitro tests. A diminution of factor XIII below 10% will extend the fibrin formation time to about 10 minutes, an increase of fibrin(ogen) splitting products to 100 micrograms/ml to about 3 minutes.
D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D005176:Factor XIII / Q000378:metabolism*; D005177:Factor XIII Deficiency / Q000097:blood*; D005337:Fibrin / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008875:Middle Aged
D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin; D005176:Factor XIII
Erfassung des Faktor-XIII-Mangels bei akuter Leukämie mit der Resonanzthrombographie.