[Whipple's disease, an example of interactions between gastrointestinal flora and the macroorganism?].
Morbus Whipple is known as a systemic disease caused by bacteria and inducing the formation of mucopolysaccharides which is absorbed by macrophages. In a mucosal bioptate of a 60 years old patient suffering from this disease we could prove numerous rod-shaped bacteria (Propionibacterium) by electronmicroscopy. In the duodenal secretion aerobic and strictly anaerobic bacteria were to be found. Therapy with tetracycline was followed by a fast and distinct improvement of the clinical symptoms of the absorption disturbances but not so clear of the histological findings.
D004064:Digestive System / Q000382:microbiology*; D004386:Duodenum / Q000382:microbiology; D004755:Enterobacteriaceae / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011424:Propionibacterium / Q000302:isolation & purification / Q000502:physiology*; D008061:Whipple Disease / Q000382:microbiology*
Morbus Whipple, ein Beispiel für Wechselwirkungen zwischen Gastrointestinalflora und Makroorganismus?