title: Toxicosis in newborn pigs associated with cutaneous application of an aerosol spray containing chlorpyrifos.
abstract: Weakness, lethargy, ataxia, lateral recumbency, limb paddling, tremors, salivation, and diarrhea were observed in newborn pigs on a commercial swine farm. Many pigs became moribund and died. All had been treated with an aerosol wound spray containing 2.5% chlorpyrifos. A controlled study was undertaken to determine whether the aerosol spray was the cause of these clinical signs. Pigs exposed to aerosol spray containing 2.5% chlorpyrifos at 3 hours (n = 4) and 6 hours (n = 3) after birth developed clinical signs similar to those on the farm; none survived. Pigs exposed at 24 hours (n = 5) after birth developed clinical signs consistent with those that had developed in pigs on the farm; 3 died and 2 survived. Of 3 pigs exposed to the same spray at 36 hours after birth, 1 developed tremors 7.5 hours later and diarrhea 9 hours later, then returned to normal.
mesh_terms: D000336:Aerosols; D000818:Animals; D000831:Animals, Newborn; D004390:Chlorpyrifos / Q000008:administration & dosage / Q000506:poisoning*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced*; D014946:Wound Infection / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000336:Aerosols; D004390:Chlorpyrifos