[Changes in the density of L-glutamate- and glycine-activated currents in the membranes of spinal cord nerve cells in the early stages of chick embryo development].
The changes in densities of L-glutamate- and glycine-activated currents through the membrane of spinal neurons were investigated in 6-11 day chick embryos using enzymatic isolation of cells and voltage clamp technique. General tendency of the current density increase during cell differentiation was found. A considerable decrease of the glycine-activated current density against a background of such an increase was observed on the 9th day of incubation. Reciprocal relation between L-glutamate- and glycine-activated current densities was found for a single neuron. Functional significance of the revealed density changes is discussed in connection with the development of the locomotor function of the spinal cord.
D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D005998:Glycine / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008124:Locomotion; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000196:embryology; D013268:Stimulation, Chemical
D005971:Glutamates; D007473:Ion Channels; D018698:Glutamic Acid; D005998:Glycine
Izmenenie plotnosti L-glutamat- i glitsinaktiviruemykh tokov v membranakh nervnykh kletok spinnogo mozga na rannikh étapakh razvitiia kurinogo émbriona.