Modulating effect of beta-endorphin, somatostatin, substance P and vasoactive intestinal peptide on the proliferative response of peripheral blood T lymphocytes of nickel-allergic patients to nickel sulfate.
The influence of beta-endorphin, somatostatin, substance P (SP) and vasoactive intestinal peptide (VIP) was tested on the proliferative response of peripheral blood T lymphocytes of nickel-allergic subjects to nickel sulfate. With somatostatin, 10(-6)-10(-10) M, SP, 10(-9) and VIP, 10(-7)-10(-8) M, added 1 h after nickel sulfate, there was an enhancement of the response, while a slight suppression was obtained with SP, 10(-6) M. At 3 days after nickel sulfate, beta-endorphin, 10(-6)-10(-12) M, somatostatin, 10(-7)-10(-9) M and SP, 10(-7)-10(-11) M, gave an enhancement of the response.
D002478:Cells, Cultured; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D009532:Nickel / Q000276:immunology*; D013004:Somatostatin / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D001615:beta-Endorphin; D009532:Nickel