title: The optic tectum regulates the transport of specific proteins in regenerating optic fibers of goldfish.
abstract: The pattern of rapidly-transported proteins in regenerating optic fibers of the adult goldfish is regulated by interactions between these fibers and their main target, the optic tectum. When the optic fibers are allowed to interact with the tectum, the transport of proteins with molecular weights in the range of 110-145 kilodaltons (kDa) increases, whereas the transport of proteins in the 24-27 kDa range declines from the previously high level which has been induced by axotomy. If the optic fibers are prevented from interacting with the tectum, the transport of the 24-27 kDa proteins remains elevated for months. Amounts of other rapidly-transported retinal proteins (e.g. the acidic 43-49 kDa proteins that increase in regenerating optic fibers after axotomy) are relatively unaffected by tectal ablation.
mesh_terms: D000818:Animals; D001370:Axonal Transport; D002250:Carbon Radioisotopes; D007839:Functional Laterality; D006054:Goldfish; D007700:Kinetics; D008970:Molecular Weight; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009900:Optic Nerve / Q000502:physiology*; D011392:Proline / Q000378:metabolism; D013477:Superior Colliculi / Q000502:physiology*; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D009419:Nerve Tissue Proteins; D014316:Tritium; D011392:Proline