Effect of substance P on the membrane potential of rat adrenal chromaffin cells.
The effect of substance P on the membrane potential of adrenal chromaffin cells from rats was investigated in tissue slices. At a concentration of 10(-7) M, substance P caused a significant depolarization of the chromaffin cell membrane from -27.5 +/- 1.9 mV to -17.9 +/- 1.30 mV. These results suggest that substance P may have a direct excitatory effect on adrenal chromaffin cell membranes.
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000313:Adrenal Medulla / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002838:Chromaffin System / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011921:Rats, Inbred WKY; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P