title: Origin of frontal N15 component of somatosensory evoked potential in man.
abstract: Origin of the frontal somatosensory evoked potential (SEP) by median nerve stimulation was investigated in normal volunteers and in patients with localized cerebrovascular diseases, and the following results were obtained. (1) In normal subjects, SEPs recorded at F3 (or F4) contralateral to the stimulating median nerve were composed of P12, N15, P18.5 and N26. Similar components were recognized in SEP recorded at Fz. (2) In patients in whom putaminal or thalamic hemorrhages had destroyed the posterior limbs of the internal capsules, frontal N15 and parietal N18 (N20) disappeared. These components were also absent in patients with cortical (parietal) infarctions. Among these patients, the thalamus was not affected in cases with putaminal hemorrhages and cortical infarctions. These facts indicate that the generator of the frontal N15 does not exist in the thalamus but that it originates from the neural structure central to the internal capsule, which suggests a similarity to the generator of the parietal N18. Because N15 was recorded in the midline of the frontal region with shorter latency than parietal N18, the frontal N15 might represent a response to the sensory input of the frontal lobe via the non-specific sensory system.
mesh_terms: D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000503:physiopathology; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006406:Hematoma / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged