The metabolism of dopamine in the blood of ruminant animals: formation of 3,4-dihydroxyphenylacetaldehyde.
A stable derivative of 3,4-dihydroxyphenylacetaldehyde (DOPAL) has been prepared that yields a solution of the parent aldehyde when dissolved in 1 M-hydrochloric acid. Dopamine, when injected into the bloodstream of a sheep, is metabolized to DOPAL which is then converted to 3,4-dihydroxyphenylethanol by aldehyde reductase activity associated with the cellular components of the blood, most probably the erythrocytes. In vitro, dopamine is metabolized by ruminant blood plasma to DOPAL, not to DOPET as previously reported. Dopamine is as good a substrate for sheep plasma amine oxidase as benzylamine. The plasma amine oxidase of ruminant animals could be a protection against the effects of dopamine released from the mast cells in these species.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000031:analogs & derivatives / Q000097:blood*; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000097:blood*; D005260:Female; D008995:Monoamine Oxidase / Q000097:blood; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000097:blood*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000097:blood; D012418:Ruminants / Q000097:blood*
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; C005975:3,4-dihydroxyphenylethanol; C007430:3,4-dihydroxyphenylacetaldehyde; D008995:Monoamine Oxidase; D010626:Phenylethyl Alcohol; D004298:Dopamine