[Ketoconazole inhibits the conductance K+ induced by thyreoliberin (TRH) in GH3 cells].
Ketoconazole an imidazole derivative used in clinical practice as an antifungal medicine interferes with the phospholipid dependent "second messenger" pathway. In this work we show that in the GH3 clonal cell line, ketoconazole (10 microM) inhibits part of the complex pattern of electrical activity induced by Thyrotropin-Releasing Hormone (TRH, 10 nM). The phase blocked by ketoconazole represents the Ca2+ -activated K+ conductance.
D002460:Cell Line; D004594:Electrophysiology; D007473:Ion Channels / Q000378:metabolism; D007654:Ketoconazole / Q000494:pharmacology*; D011188:Potassium / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors*
D007473:Ion Channels; D013973:Thyrotropin-Releasing Hormone; D007654:Ketoconazole; D011188:Potassium
Le kétoconazole inhibe la conductance K+ induite par la thyréolibérine (TRH) dans les cellules GH3.