[Stabilization of donor blood with thrombin inhibitors].
The content of free calcium ions in stored blood can be maintained by stabilizing it with thrombin inhibitors. With regard to a long-term stabilization of blood or blood plasma, satisfactory results can only be achieved with the competitive synthetic thrombin inhibitor 4-amidinophenylpyruvic acid by adding slight amounts of heparin and by storing it in a cool room. By using hirudin (greater than 50 ATE/ml of blood) the stabilization of blood enables a long-lasting anticoagulative effect to be achieved, such as it is required for the purpose of reprocessing blood to plasma fractions.
D000991:Antithrombins / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D001782:Blood Donors; D001793:Blood Preservation / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000494:pharmacology; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D010667:Phenylpyruvic Acids / Q000494:pharmacology; D010949:Plasma / Q000187:drug effects; D013450:Sulfones / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors
D000991:Antithrombins; D006629:Hirudins; D010667:Phenylpyruvic Acids; D013450:Sulfones; C006492:amidinophenylpyruvic acid; C002010:4-(2-aminoethyl)benzenesulfonylfluoride; D006493:Heparin
Untersuchungen zur Stabilisierung von Spenderblut mit Thrombininhibitoren.