[Therapy of varicose ulcer using crilanomer and dextranomer].
148 patients with leg ulcers were treated in 14 clinics with Clinagel or with Debrisan Paste for four weeks. The size of the surface of the ulcer and the overall evaluation of the ulcer by physician before and after treatment were the most important criteria for the assessment of efficacy. The comparison between the two treatments was carried out by t- and x2-test at the level of a = 0.05. Clinagel was shown to be better than Debrisan. Its superiority was statistically significant in regard to reduction of area, depth, pain and swelling, increase of granulation tissue, reepithelialisation of ulcer and the subjective judgement of physician and patient. No systemic side effects were observed in any of the patients and only slight local side effects were registered.
D000181:Acrylonitrile / Q000627:therapeutic use*; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D011897:Random Allocation; D013213:Starch / Q000627:therapeutic use*; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
D003911:Dextrans; D009570:Nitriles; D011108:Polymers; C013471:dextranomer; C052197:Clinagel; D013213:Starch; D000181:Acrylonitrile
Therapie von Ulcus cruris venosum mit Crilanomer und Dextranomer.