Amphibian cornea as a model for studying intrinsic activities of loop diuretics.
The inhibitory activity of various standard diuretics and compounds on Cl- transport in the toad cornea has been investigated. The relative potency of these diuretics shows a pattern and follows a sequence similar to their inhibitory potency on salt reabsorption in the isolated mammalian cortical thick ascending limb of Henle's loop. The suitability and convenience of using toad cornea as an in vitro model for that segment of the mammalian nephron is well demonstrated.
D000818:Animals; D001539:Bendroflumethiazide / Q000494:pharmacology; D001693:Biological Transport, Active; D002024:Bufo marinus; D002712:Chlorides / Q000378:metabolism; D003315:Cornea / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006852:Hydrochlorothiazide / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008138:Loop of Henle / Q000187:drug effects; D008297:Male; D008954:Models, Biological; D013449:Sulfonamides / Q000494:pharmacology; D053778:Thiazolidines; D000096926:Benzenesulfonamides
D001539:Bendroflumethiazide; D002712:Chlorides; D004121:Dimethyl Sulfoxide; D004232:Diuretics; D006852:Hydrochlorothiazide; D007473:Ion Channels; D013449:Sulfonamides; D053778:Thiazolidines; C023449:tizolemide; D000096926:Benzenesulfonamides