title: Drugs derived from thiazole and imidazole or with nitrogen-carbon-sulphur or tertiary amino groups. Prediction of secondary antithyroid activity by UV/visible spectroscopy.
abstract: The chemical structure of various drugs suggests their potential interference with thyroid metabolism by complexing molecular iodine in the thyroid gland. Spectroscopic analysis shows that such compounds form charge-transfer complexes with iodine in a 1:1 stoichiometry. The values of formation constant Kc indicate strong donor-acceptor interactions. Biochemical and histological studies carried out on the rat demonstrated that a correlation exists between the Kc values and the antithyroid activity. A mechanism of action of these molecules on thyroid function is proposed. The potential antithyroid activity of such compounds can therefore be predicted from the Kc values.
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet; D013844:Thiazoles / Q000032:analysis / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology
chemical_list: D013956:Antithyroid Agents; D007093:Imidazoles; D013844:Thiazoles