Certain biological function of leukocytes in venous thrombosis and influence of factors released during clot lysis.
In patients with venous thrombosis the behaviour of leukocyte random locomotion, migration, phagocytosis, blast transformation and NBT reduction properties were investigated. During the course of venous thrombosis the leukocyte adherence activity and their NBT reduction properties increased whereas their random locomotion decreased. The lymphocytes evaluated by the migration and blast transformation tests showed no signs of stimulation nor was their immunologic response changed. The thermolabile factor present in the clot lysis products affected only the adherence activity and the NBT reduction properties.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis / Q000187:drug effects; D013924:Thrombophlebitis / Q000276:immunology*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D009580:Nitroblue Tetrazolium; D014568:Urokinase-Type Plasminogen Activator