The autoimmune mouse MRL/Mp-lpr/lpr contains cells with spontaneous cytotoxic activity against target cells bearing self-determinants.
Spontaneously cytotoxic cells possessing specificity and having a complex pattern of reactivity directed at least partly against self-determinants develop by the age of 10 weeks in the autoimmune mouse strain MRL/Mp-lpr/lpr (MRL-lpr) and by the age of 6 months in C57BL/6-lprl/lpr. Similar effector cells do not develop in either MRL/Mp-+/+(MRL-+/+) or normal C57BL/6 mice up to 6 months old. Freshly prepared suspensions of both lymph node and bone marrow cells from individual MRL-lpr mice could kill Con A- or LPS-induced blast cells and fresh thymocytes from MRL-+/+ and other mouse strains with strong preference for strains carrying (self)-H-2k determinants in a 4-hr51Cr release assay. These results imply that self-reactive cells are generated as part of the lpr gene defect.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001324:Autoantigens / Q000032:analysis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D001854:Bone Marrow Cells; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D005260:Female; D008198:Lymph Nodes / Q000166:cytology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013602:T-Lymphocytes, Cytotoxic / Q000145:classification / Q000276:immunology*
D000954:Antigens, Surface; D001324:Autoantigens; D000939:Epitopes