Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment. Sural nerve biopsy revealed mild demyelination and many inclusion bodies in the axoplasm and in Schwann cell cytoplasm. Improvement in her condition was evident 6 months after discontinuing amiodarone.
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D002526:Cerebellar Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D013577:Syndrome; D013997:Time Factors
D000638:Amiodarone