[Effect of glutaraldehyde on the activation and inactivation of sodium channels in frog nerve fibers].
Effect of glutaraldehyde on gating of sodium channels was studied in the nodal membrane of the frog nerve fibre. After treatment the inactivation became slower, incomplete and the steepness of its voltage-dependence considerably decreased. The activation became slower and the steepness of its voltage-dependence decreased though both effects for the activation were less pronounced than for the inactivation. Effective charge of the activation as determined from the limiting logarithmic slope of the activation curve did not change significantly. Possible explanations of the phenomena observed are discussed.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism; D009412:Nerve Fibers / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D011895:Rana ridibunda; D012964:Sodium / Q000378:metabolism*
D000447:Aldehydes; D003432:Cross-Linking Reagents; D007473:Ion Channels; D008565:Membrane Proteins; D012964:Sodium; D005976:Glutaral
Vliianie glutaral'degida na aktivatsiiu i inaktivatsiiu natrievykh kanalov nervnogo volokna liagushki.