Effect of encephalomyocarditis (EMC) virus on murine foetal and placental growth monitored by quantification of maternal plasma levels of pregnancy-associated murine protein-2 and alpha-fetoprotein.
The present study demonstrates that pregnant mice seem to be more sensitive to encephalomyocarditis (EMC) infection than non-pregnant mice, and the infection results in significantly increased maternal plasma levels of insulin and pregnancy-associated murine protein-2 (PAMP-2), of placental origin, and alpha-fetoprotein (AFP), of foetal origin. Maternal plasma levels of PAMP-2 and AFP are correlated with placental and foetal growth respectively. This indicates that the EMC infection and the increased peripheral insulin levels lead to increased growth of the foetoplacental unit.
D000818:Animals; D005314:Embryonic and Fetal Development; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005333:Fetus / Q000378:metabolism; D007328:Insulin / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000503:physiopathology; D011257:Pregnancy Proteins / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis*
D007328:Insulin; D011257:Pregnancy Proteins; D000509:alpha-Fetoproteins; C048775:pregnancy-associated murine protein 2