Depression of protective mechanism during the early phase of a viral infection in tumor-bearing mice and prevention by PSK.
Effector mechanisms responsible for resistance against ectromelia virus including antiviral activity of non-immune macrophages, antiviral antibody, delayed footpad reaction to viral antigen, and interferon induction after viral infection were depressed in BALB/c mice bearing syngeneic Meth A tumor. The degree of viral growth correlated well with the depression of delayed footpad reaction, antibody production, and interferon induction. Therefore, modification of macrophage functions by a tumor-bearing state and treatment with PSK may contribute to this modification of antiviral resistance, at an early phase of infection. Cytotoxic activity may not be the principal effector, since the cytotoxicity was induced in normal and tumor-bearing mice to almost the same extent yet an extensive viral growth occurred only in the latter.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000998:Antiviral Agents / Q000627:therapeutic use*; D004481:Ectromelia virus / Q000254:growth & development; D004482:Ectromelia, Infectious / Q000188:drug therapy / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007372:Interferons / Q000032:analysis; D007700:Kinetics; D008099:Liver / Q000032:analysis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011213:Poxviridae Infections / Q000276:immunology*; D011509:Proteoglycans / Q000627:therapeutic use*; D013154:Spleen; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000914:Antibodies, Viral; D000998:Antiviral Agents; D011509:Proteoglycans; C010770:polysaccharide-K; D007372:Interferons