BAY K 8644, a calcium channel agonist, inhibits renin secretion in vitro.
These experiments were designed to characterize the renin secretory effects of BAY K 8644, a dihydropyridine derivative which acts as a Ca channel agonist. The rat renal cortical slice preparation was used. BAY K 8644 produced a concentration-dependent inhibition of basal renin secretion. Although the inhibitory effect was not blocked by nifedipine or by methoxyverapamil in concentrations which effectively block the renin secretory effects of K-depolarization, higher concentrations did block. Moreover, chelating extracellular Ca2+ with EGTA also blocked the inhibitory effect. These observations are consistent with the hypothesis that the inhibitory effect is mediated by Ca2+ influx. Collectively, the results add to the growing evidence that Ca2+ is an inhibitory second messenger in the renin secretory process.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
D002121:Calcium Channel Blockers; D002614:Chelating Agents; D011189:Potassium Chloride; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D012083:Renin; D002118:Calcium