A Drosophila mutation that eliminates a calcium-dependent potassium current.
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that IC plays the major role in its repolarization.
D015761:4-Aminopyridine; D000200:Action Potentials; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004330:Drosophila; D005260:Female; D007473:Ion Channels / Q000502:physiology*; D009132:Muscles / Q000502:physiology; D009154:Mutation; D011188:Potassium / Q000378:metabolism*
D000631:Aminopyridines; D007473:Ion Channels; D015761:4-Aminopyridine; D011188:Potassium; D002118:Calcium