[Effect of hydrocortisone on the level and metabolism of phospholipids in the rat cerebral cortex].
Hydrocortisone was studied for its effect in vivo and in vitro on the phospholipids content and metabolism in the rat brain slices under conditions of their incubation in the medium with [2-14C]acetate. The seven-day administration of the preparation increases the specific radioactivity of sphingomyelin 2 times and that of phosphatidyl serine 2.3 times. The quantity of phosphatidic acid after the single administration of hydrocortisone decreases almost twice and its specific radioactivity (1 mg per 100 g of mass) increases two times. Under conditions of the preparation action in vitro the specific radioactivity of phosphatidyl inositol increases on the average five times. The 10(-4) M concentration of hydrocortisone in the medium makes the quantity of phosphatidic acid 1.4 times lower and the specific radioactivity of phosphatidyl-ethanol amine 1.9 times lower. Results of the study are discussed as related to the role of phospholipids in the processes of ionic transport and regulation of the genome activity.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007473:Ion Channels; D008563:Membrane Lipids; D010743:Phospholipids; D006854:Hydrocortisone
Vliianie gidrokortizona na soderzhanie i obmen fosfolipidov v tkani kory mozga krys.