Interaction of deletional alpha-thalassaemia with sickle cell beta-thalassaemia and its influence on foetal haemoglobin expression.
A rare association of three haemoglobin defects, viz: traits for deletion form of alpha-thalassaemia, beta-thalassaemia, and sickle cell gene, in a family of French West Indies origin, was studied both at phenotype and genotype levels. In this sickle cell beta-thalassaemia, interacting alpha-thalassaemia is shown to influence the foetal haemoglobin expression. A reverse relationship between the foetal haemoglobin level and the number of alpha genes was observed.
D000755:Anemia, Sickle Cell / Q000235:genetics*; D002648:Child; D005319:Fetal Hemoglobin / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D010375:Pedigree; D010641:Phenotype; D012805:Sickle Cell Trait / Q000235:genetics*; D013789:Thalassemia / Q000235:genetics*
D005319:Fetal Hemoglobin