[Basic study on human interferon-beta: Part III. The mechanisms of its antitumor effect].
The mechanisms of the direct and indirect antitumor effects of human interferon-beta (IFN-beta, MR-21) were examined. IFN-beta suppressed DNA, RNA and protein synthesis in cells derived from human tumor. The expression of cellular oncogenes (c-Ha-ras and c-myc) in tumor-originated cells was also suppressed by IFN-beta. These results suggest that such suppression is one possible mechanism of the direct anticellular effect induced by IFN-beta. IFN-beta augmented NK cell activity and the ADCC activity of human peripheral blood lymphocytes. It is also suggested that these are two of the immune system-mediated mechanisms responsible for the indirect antitumor effect of IFN-beta in vivo.
D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D007938:Leukemia / Q000276:immunology*; D008545:Melanoma / Q000276:immunology*; D009857:Oncogenes; D012313:RNA / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000276:immunology*
D007370:Interferon Type I; D012313:RNA; D004247:DNA