[Use of the liposomal forms of a terrilytin preparation for the lysis of experimental thrombi].
Thrombolytic activity of liposomal terrilytin forms has been experimentally studied. Liposomal terrilytin form (50-280 PU/kg) was administered to rabbits 24 hours after the experimental induction of femoral thrombi. In 43.75% of cases complete lysis of the thrombi was noted, in 37.5% of cases different stages of the lysis of wall thrombi were observed and in 18.75% of cases the thrombi remained. In the control experiments the thrombi remained in 75% of cases, while in 25% of cases spontaneous lysis of the thrombi occurred. Statistically significant hemostasis changes gave evidence of the decrease in the blood clotting activity after oral administration of a liposomal terrilytin form. It has become possible to achieve thrombolytic effect using lower doses of orally administered liposomal terrilytin form, which is both therapeutically and economically important.
D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005268:Femoral Vein; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects; D066298:In Vitro Techniques; D008081:Liposomes / Q000008:administration & dosage*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011817:Rabbits; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors
D004338:Drug Combinations; D005343:Fibrinolytic Agents; D008081:Liposomes; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Ispol'zovanie liposomal'nykh form preparata terrilitina dlia lizisa éksperimental'nykh trombov.