title: Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules.
abstract: An unusual nodular transformation of the liver was found in a 53-year-old man with meningoencephalitis who died of brain stem herniation. Postmortem examination revealed marked neuronal ischemic changes and bronchopneumonia as well as meningoencephalitis. The liver showed no significant lesions macroscopically. Histologically, there were many small nodules, less than 1 mm in diameter and composed of clear hepatocytes, throughout the liver. The liver cells in these nodules showed mild hyperplastic changes. Many fine granules, stained by orcein and Victoria blue, were found exclusively in the hepatocytes of these nodules. We describe the peculiar histopathology of this case with reference to some related lesions.
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D004396:Coloring Agents; D003300:Copper / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008115:Liver Regeneration; D008297:Male; D008590:Meningoencephalitis / Q000473:pathology; D008875:Middle Aged; D009930:Organic Chemicals; D010078:Oxazines; D013194:Staining and Labeling
chemical_list: D002352:Carrier Proteins; D004396:Coloring Agents; D009930:Organic Chemicals; D010078:Oxazines; C023548:copper-binding protein; C041370:victoria blue; C002313:PAcein; D003300:Copper