Inguinal sweat gland carcinoma with choriocarcinomatous differentiation.
An inguinal sweat gland carcinoma is described including the unusual occurrence of alpha hCG. The alpha hCG was demonstrated in the tumor presenting choriocarcinomatous differentiation and undifferentiated polygonal cells in ordinary tumor nests. beta hCG and SP-1 were weakly and sporadically demonstrated in a small area of the tumor presenting choriocarcinomatous differentiation. On the other hand, hPL and histochemical reaction of placental type alkaline phosphatase were not observed in the choriocarcinomatous and undifferentiated tumor cells. CEA was observed in both ordinary sweat gland carcinoma nests and choriocarcinomatous differentiated regions. In the ordinary tumor nests, enzyme histochemical reactions of phosphorylase and SDH were positive. And S 100 protein was sporadically demonstrated. In spite of chemotherapy and radiotherapy, the patient died after a short duration of the disease.
D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000097:blood / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D002822:Choriocarcinoma / Q000097:blood / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D006063:Chorionic Gonadotropin / Q000032:analysis; D005260:Female; D015292:Glycoprotein Hormones, alpha Subunit; D006801:Humans; D007264:Inguinal Canal / Q000473:pathology; D010446:Peptide Fragments / Q000032:analysis; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013544:Sweat Gland Neoplasms / Q000097:blood / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D000509:alpha-Fetoproteins / Q000032:analysis
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D015292:Glycoprotein Hormones, alpha Subunit; D010446:Peptide Fragments; D011268:Pregnancy-Specific beta 1-Glycoproteins; D009418:S100 Proteins; D000509:alpha-Fetoproteins; D010928:Placental Lactogen