Distribution and possible abnormality in antigenic composition of sodium channels in peripheral axons of dystrophic mice.
In some dystrophic mice (Bar-Harbour 129 dy/dy), axons of the sciatic nerve are a-myelinated but are capable of carrying action potentials. In this study, we showed by immunofluorescence that such excitability is supported by the presence of voltage-gated sodium channels along the a-myelinated axon. In addition, the number of sodium channels measured by radioimmunoassay in sciatic nerves of these dystrophic mice is significantly higher. Furthermore, the composition of sodium channel epitopes is abnormal. This suggested a link between the disease and the biogenesis of the sodium channels.
D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D007473:Ion Channels / Q000276:immunology* / Q000502:physiology; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000276:immunology* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology* / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D000941:Antigens; D007473:Ion Channels; D012964:Sodium