Focal eosinophilic hypertrophic cells of the rat pancreas.
Focal spontaneously occurring eosinophilic hypertrophic cells, histomorphologically resembling oncocytes and hepatocytes, were observed in the pancreas from 11 (0.3%) of 4,177 Sprague-Dawley rats, 3 to 26 months old. The age of these eleven rats ranged from 13 to 25 months. The incidence was not different between sexes. The altered cells were usually seen in the peri-insular area. Two types of foci, uniform and pleomorphic, were classified on the basis of uniformity of size of the altered cells within a focus. The origin and nature were not determined for the altered cells/foci reported in this study but they were not considered to be neoplastic.
D000818:Animals; D004801:Eosine Yellowish-(YS); D005260:Female; D006984:Hypertrophy / Q000662:veterinary; D008297:Male; D010179:Pancreas / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology*; D013194:Staining and Labeling
D004801:Eosine Yellowish-(YS)