Delivery of antifibroblast agents as adjuncts to filtration surgery. Part I--Periocular clearance of cobalt-57 bleomycin in experimental drug delivery: pilot study in the rabbit.
Antitumor and antifibroblast agents show promise as adjuncts after glaucoma filtration surgery in reducing postoperative scarring and failure. We used nuclear imaging in rabbits to investigate periocular clearance of one such agent (57Co-bleomycin). Sub-Tenon injection was compared to other delivery techniques. Our results showed that a collagen sponge and a silastic disc implant with a microhole prolonged drug delivery when compared to sub-Tenon injection alone or injection with a viscosity enhancing agent (0.5% sodium hyaluronate). We theorize that if an antifibroblast agent can be delivered in small and sustained amounts after filtration surgery, this may prolong bleb longevity and avoid unnecessary drug toxicity.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D003037:Cobalt Radioisotopes; D003094:Collagen; D004343:Drug Implants; D005123:Eye / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000187:drug effects*; D005374:Filtration; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007267:Injections; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D010865:Pilot Projects; D011182:Postoperative Care; D011817:Rabbits; D012826:Silicone Elastomers; D013997:Time Factors
D003037:Cobalt Radioisotopes; D004343:Drug Implants; D012826:Silicone Elastomers; D001761:Bleomycin; D006820:Hyaluronic Acid; D003094:Collagen