Effects of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland.
The action of substance P on glycoprotein secretion from acinar cells of the rat submandibular gland was described in this report. Salivation elicited by i.v. injection of 0.5 to 20 micrograms/kg of substance P was increased dose-dependently, and its flow rate was highest at the first 1 min. Major glycoprotein species secreted into saliva by substance P-stimulus were shown to be electrophoretically identical with those found in acini, but not granular convoluted tubules. These results support the view that substance P acts on acinar cells of the submandibular gland and stimulates secretion of saliva from the cells.
D000818:Animals; D006023:Glycoproteins / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012472:Salivation / Q000187:drug effects; D013363:Submandibular Gland / Q000166:cytology / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*
D006023:Glycoproteins; D013373:Substance P