[Importance of calcium ions and impulse activity for neurotrophic control of the membrane potential of muscle fibers in the rat].
The blockade of the Ca++ influx increased the postdenervation depolarization of the membrane potential in rat diaphragm muscle fibres, while elevation of the intracellular Ca++ content by caffeine hyperpolarized the muscle membrane. Direct electrical stimulation of muscle or application of carbamylcholine reduced the degree of postdenervation membrane depolarization. Verapamil and d-tubocurarine abolished the hyperpolarizing effect of the electrical stimulation. The hyperpolarizing effects of carbamylcholine and electrical stimulation were not added. It is suggested that the influx of the extracellular Ca++ through acetylcholine-sensitive ionic channels in the external muscle membrane contributes to the neurotrophic regulation of the membrane potential in rat muscle fibres.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D003714:Denervation; D003964:Diaphragm / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000294:innervation / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology; D051381:Rats; D013997:Time Factors
D007473:Ion Channels; D002118:Calcium
Znachenie ionov kal'tsiia i impul'snoĭ aktivnosti dlia neĭrotroficheskogo kontrolia membrannogo potentsiala myshechnykh volokon krysy.