title: Response of multiple syringomas to isotretinoin.
abstract: Two female patients with multiple syringomas were treated for 5/6 months with cumulative doses of 9 and 11 g isotretinoin respectively. Clinically, the appearance of the lesions in both patients improved from the third month on. After therapy, the lesions were flattened, softened, and skin coloured. Histologically, a marked reduction of size and numbers of syringomas was observed, and the contents of cystic lesions seemed reduced 6 months after therapy. Ultrastructurally, changes in the cystic and ductal epithelium correspond with the keratin modulating efficacy of the drug, but also point at a drug-induced change in intracellular lipid composition.
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000648:ultrastructure; D000328:Adult; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008854:Microscopy, Electron; D013544:Sweat Gland Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin