[Enoxacin concentration in human prostatic tissue].
The present study was under taken to evaluate the penetration of enoxacin into prostatic tissue. Ten patients with benign prostatic hypertrophy entered the study. Enoxacin was administered orally at a dose of 200 mg, three times one day before and twice on the day of operation. Blood and urine samples were taken 30 min before operation and prostatic tissue samples were taken during operation. The mean concentration of enoxacin was 4.87 +/- 1.39 micrograms/ml in serum and 5.81 +/- 2.95 micrograms/g in the prostatic tissue. The mean ratio of the prostatic concentration/serum concentration was 1.21 +/- 0.63 (range 0.82-3.00).
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism*; D015365:Enoxacin; D006801:Humans; D008297:Male; D009287:Naphthyridines / Q000008:administration & dosage / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism
D000890:Anti-Infective Agents; D009287:Naphthyridines; D015365:Enoxacin