[Cytotoxic activity of normal killers and the lymphocytic proliferative response to specific viral antigens in influenza in mice].
Inoculation of CBA mice with pathogenic influenza A/PR8/34 (H1N1) virus and non-pathogenic A/Krasnodar/101/59 (H2N2) virus demonstrated that the pathogenic strain enhanced the synthesis of serum interferon and activated the function of normal killers, but had a relatively low capacity of causing in vitro proliferative response of spleen lymphocytes of intact and in vivo primed animals. In contrast, the nonpathogenic virus had less marked interferon-inducing capacity and that of activating normal killers, but induced a very high proliferative response of lymphocytes in culture.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity; D007372:Interferons / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000956:Antigens, Viral; D000939:Epitopes; D007372:Interferons
Tsitotoksicheskaia aktivnost' normal'nykh killerov i proliferativnyĭ otvet limfotsitov na spetsificheskie virusnye antigeny pri grippoznoĭ infektsii u mysheĭ.