Urinary excretion of 5-hydroxyindoleacetic acid, delta-aminolevulinic acid and coproporphyrin isomers in rats and men exposed to lead.
The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), delta-aminolevulinic acid (ALA) and coproporphyrin (CP) isomers (I and III) was investigated in rats and workers exposed to lead. Urinary excretion of 5-HIAA, which is the major metabolite of serotonin, was not influenced by the lead exposure. However, a significant increase in urinary ALA and CP was found in rats and workers exposed to lead. In particular, the urinary excretion of CP-III was markedly increased compared to that of CP-I in rats and workers exposed to lead.
D000284:Administration, Oral; D000622:Aminolevulinic Acid / Q000652:urine*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003306:Coproporphyrins / Q000652:urine*; D004781:Environmental Exposure; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000378:metabolism*; D007982:Levulinic Acids / Q000652:urine*; D008297:Male; D011166:Porphyrins / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D003306:Coproporphyrins; D007982:Levulinic Acids; D011166:Porphyrins; D007854:Lead; D006897:Hydroxyindoleacetic Acid; D000622:Aminolevulinic Acid