title: Co-existence of prodynorphin--opioid peptides and substance P in primary sensory afferents of guinea-pigs.
abstract: Light microscopic immunoenzymatic and immunofluorescence histochemistry revealed co-existence of opioid peptides with substance P in primary sensory neurons of all segmental dorsal root and trigeminal ganglia of guinea-pig. Sensory opioid peptides appeared to be exclusively processed from prodynorphin and include [Leu]enkephalin, neoendorphins, and dynorphin A. We suggest the presence of presynaptic opioid autoreceptors in primary sensory afferences.
mesh_terms: D000344:Afferent Pathways / Q000166:cytology*; D000818:Animals; D004723:Endorphins / Q000032:analysis*; D004745:Enkephalins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D005724:Ganglia / Q000166:cytology; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology*; D011498:Protein Precursors / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
chemical_list: D004723:Endorphins; D004745:Enkephalins; D011498:Protein Precursors; D013373:Substance P; C033660:preproenkephalin