[Role of antigen-nonspecific suppressors occurring in stress in the pathogenesis of Langat virus infection in mice].
Stress factors of different nature activate antigen-nonspecific suppressors inhibiting different mechanisms of immune response in mice. The adoptive transfer of the population of immunocompetent cells containing stress-induced suppressors to mice infected with Langat virus has been found to lead to the activation of asymptomatic infection. The data obtained in this investigation indicate that the above-mentioned mechanism of the development of antigen-nonspecific immune deficiency is of importance in the pathogenesis of viral infections in man and it explains the onset of diseases (or their aggravation) under the conditions of stress.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne; D000939:Epitopes / Q000276:immunology*; D007116:Immunization, Passive; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013312:Stress, Physiological / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014036:Togaviridae Infections / Q000209:etiology* / Q000276:immunology
D000956:Antigens, Viral; D000939:Epitopes
Izuchenie roli antigennespetsificheskikh supressorov, voznikaiushchikh pri stresse, v patogeneze infektsii u mysheĭ, zarazhennykh virusom Langat.