[Comparative evaluation of the anti-arrhythmic activity of carbamazepine, novocainamide and obzidan in ventricular extrasystole].
Twenty-six patients with different diseases of the myocardium complicated by ventricular extrasystole were studied by means of intermittent 24-hour ECG-monitoring using the "Malysh" apparatus. Control of treatment was performed on the 4th-6th day. Carbamazepine effect was observed in 2/3 of patients and significantly exceeded effects of obzidan and novocainamide. No direct relationship was revealed between pharmacodynamics and pharmacokinetic parameters of carbamazepine.
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents; D002220:Carbamazepine / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011342:Procainamide / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D002220:Carbamazepine; D011433:Propranolol; D011342:Procainamide
Sravnitel'naia otsenka antiaritmicheskoĭ aktivnosti karbamazepina, novokainamida i obzidana pri zheludochkovoĭ ékstrasistolii.