Influence of histone-chondroitin sulphate A complexes on blood platelet aggregation.
The influence of histones and their complexes with chondroitin sulphate A on platelet aggregation was studied. Histones F1 and F2a1 and complex histone F1-chondroitin sulphate A do not induce platelet aggregation by themselves but they decreased threshold aggregating concentration of ADP whereas complex histone F2a1-chondroitin sulphate A increased it. The results of our study may point out to the possibility of the examined substances taking part in disturbances of the platelet function.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D004357:Drug Synergism; D006657:Histones / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*
D006657:Histones; D000244:Adenosine Diphosphate; D002807:Chondroitin; D002809:Chondroitin Sulfates