Medium-wave ultraviolet radiation (UVB) is important in doxycycline phototoxicity.
The phototoxic reaction to doxycycline is provoked by long-wave ultraviolet light (UVA). It was shown by the in vivo mouse tail technique, measuring phototoxic edema, that the addition of medium-wave ultraviolet light (UVB) immediately after, immediately before and especially 24 h before the phototoxic trauma, enhanced the reaction more than could be expected from simple addition, thus demonstrating the importance of photoaugmentation in this process.
D000818:Animals; D004318:Doxycycline / Q000633:toxicity*; D004487:Edema; D005260:Female; D051379:Mice; D010787:Photosensitivity Disorders / Q000209:etiology*; D014466:Ultraviolet Rays
D004318:Doxycycline