Skin tumors and reactive cellular infiltrate: further studies.
Twenty-two non-ulcerated basal cell carcinomas and 30 non-ulcerated squamous cell carcinomas were selected to study the reactive cellular infiltrate, utilizing histological, histoenzymatic and immunological methods. Substantial differences in cell behaviour were observed between the two tumors: advanced and metastatic squamous cell carcinoma showed prominent presence of T8+ lymphocytes, Leu 7+ cells, macrophages, mast cells and granulocytes, notably eosinophils. Degranulation of mast cells was seen both in the tumor itself and in the adjacent stroma. The basal cell carcinoma presented a low count of T4+, T8+ lymphocytes, whereas Leu 7+ cells and granulocytes were absent.
D000368:Aged; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D002280:Basal Cell Carcinoma / Q000276:immunology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D004804:Eosinophils; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007073:Immunoglobulin E; D007694:Killer Cells, Natural; D008264:Macrophages; D008297:Male; D008407:Mast Cells; D008875:Middle Aged; D010950:Plasma Cells; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal; D007073:Immunoglobulin E