title: [Anaphylactogenicity of dextran-conjugated serum globulins].
abstract: Active anaphylaxis in 238 guinea-pigs has revealed a decrease in the anaphylactogenic activity of horse blood serum IgG conjugates with dextran and of serum treated with dextran according to Diaferm method. The conjugates were used for a challenge injection. The sensitizing activity of dextran-conjugated proteins was higher than that of native proteins. The effect was most pronounced with 150,000 D dextran used as a matrix. A lower increase in sensitizing protein activity and a decrease in anaphylactogenic activity were achieved with dextran matrix of the molecular weight of 35-50 D and protein/dextran ratio from 1:6 to 1:9.
mesh_terms: D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000818:Animals; D003911:Dextrans / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D012712:Serum Globulins / Q000276:immunology*
chemical_list: D003911:Dextrans; D007074:Immunoglobulin G; D012712:Serum Globulins
vernacular_title: Anafilaktogennost' syvorotochnykh globulinov, kon''iugirovannykh s dekstranami.