[Demonstration and ontogenesis in the rat of a serum protein analogous to human thyroxine binding globulin].
It has been reported evidence based on equilibrium binding, electrophoretic, immunoelectrophoretic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). It is shown that in the sera of postnatal developing animals, between 3 and 21 days, the thyroxine (T4) and the triiodothyronine (T3) binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TBG. In the adult serum, the TBG persists in decreased amounts: it then yields the predominant role as T4 carrier to the thyroid binding prealbumin (TBPA), but retains the major role as binder of T3, i.e. of the biologically active thyroid hormone.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D005333:Fetus; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis; D013045:Species Specificity; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D000509:alpha-Fetoproteins; D014284:Triiodothyronine; D013974:Thyroxine
Mise en évidence et ontogenèse chez le rat d'une protéine sérique analogue à la "thyroxine binding globulin " (TBG) humaine.