Conformational behaviour of some tachykinin C-terminal heptapeptides.
The conformational behaviour of substance P, physalaemin and eledoisin C-terminal heptapeptides was investigated using empirical energy calculations. Although the conformational distributions of the three heptapeptides are somewhat different, they have a few common low energy conformations. Some of them, which satisfy the structure-activity relationships, may fit the well known SP-P receptors.
D002151:Calorimetry; D004600:Eledoisin; D007705:Kinins; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010446:Peptide Fragments; D010803:Physalaemin; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013373:Substance P
D007705:Kinins; D010446:Peptide Fragments; C051566:eledoisin C-terminal heptapeptide; C051565:physalaemin C-terminal heptapeptide; D010803:Physalaemin; D013373:Substance P; C031661:substance P (5-11); D004600:Eledoisin