The influence of serum and serum proteins on calcium oxalate crystal growth and aggregation.
The effects of serum, albumin, alpha-globulin, and a mixture of alpha- and beta-globulin on the growth and aggregation of calcium oxalate crystals were measured in a standard seeded crystallisation system. At concentrations below 0.01% blood, which corresponded to microscopic haematuria, all were potent inhibitors of crystal aggregation whilst only having a minor effect on crystal growth. It was found that albumin, alpha-globulin and beta-globulin can account for the total inhibitory effect of serum on crystal growth and crystal aggregation.
D000510:Alpha-Globulins / Q000494:pharmacology; D001609:Beta-Globulins / Q000494:pharmacology; D001769:Blood; D001798:Blood Proteins / Q000494:pharmacology*; D002129:Calcium Oxalate / Q000097:blood*; D003460:Crystallization; D006801:Humans; D007700:Kinetics; D012709:Serum Albumin / Q000494:pharmacology
D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D012709:Serum Albumin; D002129:Calcium Oxalate