title: Host-adaptive antigenic variation in Bunyaviruses.
abstract: Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.
mesh_terms: D000330:Aedes; D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D002042:Bunyamwera virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D002043:Bunyaviridae / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D002460:Cell Line; D002522:Chlorocebus aethiops; D000939:Epitopes; D005814:Genes, Viral; D009154:Mutation; D009500:Neutralization Tests; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*; D010948:Viral Plaque Assay; D014779:Virus Replication
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D014759:Viral Envelope Proteins