[Significance of sarcolemma damage in the pathogenesis of myocardial ischemia induced by pituitrin-isadrin and its correction using the antioxidant dibunol].
The elevation of cardiomyocyte membrane permeability has been demonstrated during pituitrin-isadrin-induced myocardial ischemia. Preventive 7-day oral administration of an antioxidant dibunol (30 and 120 mg/kg) preserved sarcolemmal integrity, decreased myocardial membrane permeability to sulfacetamide sodium, and reduced peroxide and mechanical erythrocyte hemolysis. Inhibition of lipid peroxidation with an antioxidant dibunol improved myocardial injury and decreased the death rate of animals with catecholamine-induced myocardial ischemia. These data suggest the involvement of lipid peroxidation in the development of ischemic myocardial injury.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D003327:Coronary Disease / Q000139:chemically induced* / Q000517:prevention & control; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol; D010909:Pituitary Hormones, Posterior; D051381:Rats; D012508:Sarcolemma / Q000187:drug effects*
D000975:Antioxidants; D010909:Pituitary Hormones, Posterior; D002084:Butylated Hydroxytoluene; D007545:Isoproterenol
Znachenie povrezhdeniĭ sarkolemmy v patogeneze pituitrin-izadrinovoĭ ishemii miokarda i ikh korrektsiia s pomoshch'iu antioksidanta dibunola.