Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task.
The neuropeptide substance P (SP) was injected into the region of the nucleus basalis magnocellularis (NBM). The influence of SP on the performance of the single trial "uphill avoidance task" was tested. The post-trial injection of 1 ng SP (in 0.5 microliter volume) led to significantly longer latencies in the uphill response. This result can be interpreted in terms of a facilitating effect of SP on performance of an inhibitory avoidance response.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001479:Basal Ganglia; D007267:Injections; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D013373:Substance P