Borderline hypertension and sodium sensitivity.
The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increase in cardiac dimension, stroke volume, and cardiac index, the sodium-sensitive individuals either failed to reduce vascular resistance to the same degree as normal subjects or actually vasoconstricted.
D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008833:Microcirculation / Q000187:drug effects; D012083:Renin / Q000097:blood; D012964:Sodium / Q000008:administration & dosage* / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000450:Aldosterone; D012964:Sodium; D012083:Renin