Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts.
The ability of nonadherent peripheral blood mononuclear cells of normal individuals to lyse noninfected and cytomegalovirus (CMV)-infected human fibroblasts was enhanced by preincubation with recombinant human alpha interferon (alpha-rIFN) or beta (beta-rIFN). In contrast, recombinant human gamma IFN (gamma-rIFN) augmented natural killing (NK) against both targets relatively poorly. Recombinant or natural human interleukin 2(IL-2) also augmented NK against noninfected and CMV-infected targets. Augmentation of NK by IFN or IL-2 could be blocked by the addition of corresponding antisera. IL-2-enhanced NK against CMV-infected targets was usually independent of alpha-IFN production.
D003586:Cytomegalovirus Infections / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007376:Interleukin-2 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007700:Kinetics; D011994:Recombinant Proteins / Q000494:pharmacology
D007370:Interferon Type I; D007376:Interleukin-2; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007372:Interferons