Staining qualities of cytomegalovirus inclusions in the lungs of patients with the acquired immunodeficiency syndrome: a potential source of diagnostic misinterpretation.
Gomori's methenamine silver and the periodic acid--Schiff reaction stain cytoplasmic but not intranuclear cytomegalovirus inclusions. The biochemical basis of these staining qualities is discussed, and the staining characteristics are correlated with supporting ultrastructural observations. Failure to recognize this phenomenon may lead to erroneous diagnostic conclusions at the light microscopic level.
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D003586:Cytomegalovirus Infections / Q000473:pathology*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013194:Staining and Labeling