title: Meningomyelocele: a new or a vanishing disease?
abstract: I believe meningomyelocele is not vanishing, but is a new and diminishing disorder. Prenatal diagnosis will be accepted only by a portion of most communities if abortion is the only alternative to the delivery of an impaired child. I believe participation in neural tube screening programmes can be increased by offering improved pregnancy outcome with concomitant prelabor caesarean section in addition to termination. Regardless, the prevalence at birth of children with myelomeningocele will decrease both in total numbers and in the severity of the expressed lesion. The resultant rarity will require collaboration between centers to evaluate treatment. The developing International Myelodysplasia Study Group using a Patient Data Management System and computer-assisted analysis is a model of successful collaboration that allows better exploration of the multiple variables that contribute to the well-being of children with open neural tube defects of the spine.
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D002557:Cerebrospinal Fluid Shunts; D002585:Cesarean Section; D005260:Female; D006616:Hip Contracture / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D008591:Meningomyelocele / Q000175:diagnosis* / Q000628:therapy; D010243:Paralysis / Q000517:prevention & control; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014570:Urologic Diseases / Q000628:therapy; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins