[Fibrin glue and bone regeneration].
The osteoinductive property of fibrin glue with and without admixture of aprotinin was proven in animal model. Aprotinin as an inhibitor of the fibrinolysis is supposed to be an inhibitor of the osteogenesis, too. Three holes of 4 mm diameter and 2 mm depth were placed into the diaphysis of both femura in 12 adults dogs. The defects were filled with either pure fibrin glue or with glue containing aprotinin (3000 KIE), or with nothing (vacant). After 8 weeks the quantity of the new built woven-bone was examined by plane geometry and the "Bone Metabolising Unit (BMU)" (Frost) which are crossing the border of lamellar bone and new woven bone were counted out. There was seen no statistical significantly between the three groups neither in the quantity of new bone nor in the BMU. Therefore the fibrin glue has no osteoinductive property.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D005176:Factor XIII / Q000494:pharmacology*; D005269:Femur / Q000187:drug effects; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin
Fibrinkleber und Knochenneubildung.