An antigenic determinant common to both mouse red blood cells and several membrane proteins of the parasitic protozoa Babesia rodhaini.
Four membrane proteins of Babesia rodhaini have been identified by monoclonal antibodies. These proteins are differentiated by serological criteria and by tryptic peptide maps but contain common antigenic determinants. In vitro translation of parasite polyadenylated RNA followed by immunoprecipitation demonstrates that these common determinants are located within the primary sequence of the protein and do not result from post-translational modification. Part of the common amino acid sequence of these proteins is also present within a protein found in mouse red blood cells. Such common structures could potentially play an important role in the host-parasite relationship. The presence of sequence homology within a group of proteins from Babesia rodhaini could be further evidence for the atypical genetic rearrangements proposed to take place within Babesia species.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan / Q000032:analysis*; D001403:Babesia / Q000235:genetics / Q000276:immunology*; D011232:Chemical Precipitation; D000939:Epitopes / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology* / Q000469:parasitology; D006790:Host-Parasite Interactions; D007120:Immunochemistry; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012689:Sequence Homology, Nucleic Acid
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D000939:Epitopes; D008565:Membrane Proteins