The recovery of maturing brain from acute citalopram exposure.
At various ages between birth and adulthood mice were exposed to the specific 5-HT uptake inhibitor citalopram. Their brains were assayed for indoleamine stores and turnover during the period of recovery from the drug's action. Young brain lacks the ability to fine tune its return to normal following citalopram action.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D015283:Citalopram; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000378:metabolism*; D051379:Mice; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*
D007211:Indoles; D011437:Propylamines; D012702:Serotonin Antagonists; D015283:Citalopram; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid