Effect of cold exposure on the amylase activity of submaxillary gland of rats.
Cold exposure of rats for 3 h (6 +/- 2 degrees C) caused an increase in amylase activity of the submaxillary gland. This effect was not observed in other salivary glands i.e. parotid and sublingual or in the pancreas. The increase of amylase activity during cold exposure was completely abolished by the beta-receptor antagonist, propranolol, and the alpha-receptor antagonist, phenoxybenzamine, reduced the effect. Administration of actinomycin D to the cold-exposed rats produced a tremendous increase of enzyme activity instead of abolition of the increase as had been expected.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D003080:Cold Temperature; D003609:Dactinomycin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D003609:Dactinomycin; D000681:Amylases