Effects of Chinese herbal medicine "kanbaku-taiso-to" on transmembrane ionic currents and its local anesthetic action.
The Chinese herbal medicine, "Kanbaku-taiso-to" (KT) which is a mixture of Glycyrrhizae Radix, Triticii Semen and Zizyphi Fructus, sometimes shows marked effects on insomnia, infantile convulsions and emotional irritability. To elucidate the mechanism of the sedative effect of KT, effects of KT on the transmembrane ionic currents and local anesthetic action were examined and the following results were obtained. KT showed an inhibition of sodium, calcium and potassium currents in snail neurons. KT showed an inhibitory effect on pentylenetetrazol-induced bursting activity. KT had local anesthetic action on frog nerve fibers. Together with our previous study, these results suggest that KT has an inhibitory effect on hyperexcitability of the neuronal membrane and this is the main cause of the sedative effect of KT.
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002025:Bufonidae; D004338:Drug Combinations / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D008564:Membrane Potentials / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D012908:Snails
D000779:Anesthetics, Local; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007473:Ion Channels; D010936:Plant Extracts; C049378:kanbaku taiso to; D010433:Pentylenetetrazole