[Effect of amiloride and strophanthin K on sodium transport through isolated frog skin under increased pressure].
A pressure increase up to 101 ata led to 17.8% and 50% increase of the electrical potential difference and short-circuited current, resp., as well as to a 22% decrease of electrical resistance in the isolated frog skin. The changes were due to a high hydrostatic pressure and the increase of the solution temperature by 2.8 +/- 0.14 degrees C. At 100 ata, the ability of amiloride to block Na-channels in the cell membranes of the frog skin was preserved, and inspite of the intense increase in the work of the sodium active transport system, the kinetics of inhibition of the Na-pump by strophanthin K remained the same as in case of normal pressure.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D006874:Hydrostatic Pressure; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D011896:Rana temporaria; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013328:Strophanthins / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors
D007473:Ion Channels; D013328:Strophanthins; D000584:Amiloride; D012964:Sodium; C029082:strophanthin K
Vliianie amilorida i strofantina K na transport natriia cherez izolirovannuiu kozhu liagushki pri uvelichenii davleniia.