title: [Disordered ion-transport processes in the cardiomyocyte membranes in the immune action on the heart].
abstract: Intracoronary administration of anticardiac cytotoxic serum increased the sarcolemma passive permeability for Ca2+ ions and reduced the activity of Na+-Ca2+ and Na+,K+-ATPase exchange in dogs. Electronic microscopy revealed thinning of glycocalix, destabilizing of the sarcolemma phospholipid bilayer, and development of intracellular oedema. Disturbances of the sarcolemma structure and function seem to be able to cause the development of cardiac insufficiency of immune origin.
mesh_terms: D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004285:Dogs; D006321:Heart / Q000187:drug effects; D007106:Immune Sera / Q000494:pharmacology; D007473:Ion Channels / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009206:Myocardium / Q000276:immunology* / Q000378:metabolism* / Q000648:ultrastructure; D012508:Sarcolemma / Q000378:metabolism / Q000648:ultrastructure; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
chemical_list: D002132:Calcium Radioisotopes; D007106:Immune Sera; D007473:Ion Channels; D012964:Sodium; D002118:Calcium
vernacular_title: Narushenie ion-transportnykh protsessov v membranakh kardiomiotsitov pri immunnom vozdeĭstvii na serdtse.