Involvement of antigen and I-J determinants in the induction of effector T suppressor cells by immune B cells.
Immune B cells induce effector T suppressor cells in vitro. The B cells act as antigen-presenting cells, and express both I-A and I-J determinants. Antigen and I-J determinants are required for the induction of suppressor T cells by immune B cells, but I-A determinants are not. These findings indicate that precursors of suppressor T cells appear to recognize antigen in the context of I-J determinants on the surface of immune B cells.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D001789:Blood Group Antigens / Q000276:immunology; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology*; D007518:Isoantibodies / Q000502:physiology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D012756:Sheep; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000941:Antigens; D001789:Blood Group Antigens; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; C043911:I-J-antigen; D007518:Isoantibodies