Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate.
D-Galactopyranosyl residues were coupled to poly(L-lysine) and the antiviral agents arabinofuranosyladenine 5'-monophosphate (ara-AMP) and acyclovir were conjugated with this glycosylated polymer. In mice the ara-AMP conjugate accomplished a selective drug delivery to liver cells.
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000818:Animals; D001088:Arabinonucleotides / Q000008:administration & dosage*; D004247:DNA / Q000096:biosynthesis; D005690:Galactose / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D014677:Pharmaceutical Vehicles; D011107:Polylysine / Q000008:administration & dosage*; D012709:Serum Albumin / Q000008:administration & dosage; D001084:Vidarabine Phosphate / Q000008:administration & dosage* / Q000378:metabolism
D001088:Arabinonucleotides; D014677:Pharmaceutical Vehicles; D012709:Serum Albumin; D001084:Vidarabine Phosphate; D011107:Polylysine; C026145:acyclovir monophosphate; D004247:DNA; D005690:Galactose; D000212:Acyclovir