Myelin basic protein inhibits formyl-peptide induced chemotaxis in human neutrophils.
Myelin basic protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation. Pre-treatment of human neutrophils with myelin basic protein selectively inhibits the formyl-peptide-induced chemotaxis, without affecting chemotaxis evoked by casein and activated serum. Furthermore, both the degranulation and superoxide anion production stimulated by the chemotactic peptide are not modified by the prior treatment of the neutrophils with myelin basic protein.
D002118:Calcium / Q000378:metabolism; D002364:Caseins / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D004676:Myelin Basic Protein / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000037:antagonists & inhibitors*
D002364:Caseins; D004676:Myelin Basic Protein; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002118:Calcium