[Synthesis of moraprenylpyrophosphate derivatives of 3-O-alpha-L-rhamnopyranosyl-(4-O-alpha-D-glucopyranosyl)-alpha-D- galactopyranose and 3-O-alpha-L-rhamnopyranosyl-(4-O-beta-D- glucopyranosyl)-alpha-D-galactopyranose and study of their substrate properties in reactions of the biosynthesis of O-antigenic polysaccharides of Salmonella typhimurium and Salmonella anatum].
Trisaccharides Rha alpha 1----3(Glc alpha 1----4)Gal (I) and Rha alpha 1----3(Glc beta 1----4) Gal (II) have been synthesised. Acetylation of the trisaccharides followed by the McDonald reaction gave rise to alpha-glycosyl phosphates. The latter were converted via coupling with moraprenyl phosphoimidazolidate into polyprenyl pyrophosphate derivatives of (I) and (II), which both serve as substrates for mannosylation and polymerisation reactions with enzymes form the Salmonella anatum and S. typhimurium membranes.
D000942:Antigens, Bacterial / Q000096:biosynthesis* / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D012475:Salmonella / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology; D014312:Trisaccharides / Q000138:chemical synthesis*
D000942:Antigens, Bacterial; D019081:O Antigens; D011135:Polysaccharides, Bacterial; D014312:Trisaccharides; C054047:3-O-rhamnopyranosyl-4-O-glucopyranosyl-galactopyranose
Sintez moraprenilpirofosfatnykh proizvodnykh 3-O-alpha-L-ramnopiranozil-(4-O-alpha-D-gliukopiranozil)-alpha-D- galaktopiranozy i 3-O-alpha-L-ramnopiranozil-(4-O-beta-D- gliukopiranozil)-alpha-D-galaktopiranozy i issledovanie ikh substratnykh svoĭstv v reaktsiiakh biosinteza O-antigennykh polisakharidov Salmonella typhimurium i Salmonella anatum.