[Effects of the 5-lipoxygenase inhibitor phenidone on antigen-induced release of histamine in vitro].
The 5-lipoxygenase inhibitor Phenidone inhibits the antigen-induced release of histamine from human basophiles at concentrations of 10(-4) up to 10(-5) mol/l. These findings indicate once more that products of the arachidonic acid metabolism are involved in the induction of histamine release from human basophiles.
D000485:Allergens / Q000276:immunology*; D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D001491:Basophils / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles / Q000494:pharmacology*
D000485:Allergens; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D001091:Arachidonate Lipoxygenases; C015429:phenidone
Einfluss des 5-Lipoxygenasehemmers Phenidon auf die antigenbedingte Histaminfreisetzung in vitro.