Cytotoxic T lymphocyte clone recognizing self idiotype: its regulatory role in antibody production.
MOPC 104E idiotype-specific cytotoxic T lymphocyte (CTL) clones were established. The clone KA1.02 specifically killed MOPC 104E cells and inhibited anti-dextran antibody production in an idiotype-specific manner. Both cytotoxicity and antibody inhibition were restricted to the cross-reactive idiotype and class I histocompatibility antigen. The data presented here provide definitive evidence that the self idiotype is the immunogenic determinant recognized by T lymphocytes in association with the major histocompatibility complex product. A regulatory role of CTL in antibody response is proposed.
D000818:Animals; D000917:Antibody Formation; D001324:Autoantigens / Q000276:immunology*; D002460:Cell Line; D002999:Clone Cells; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D003911:Dextrans / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D001324:Autoantigens; D003911:Dextrans; D004136:Dinitrobenzenes; D006183:H-2 Antigens; D007130:Immunoglobulin Idiotypes