Tumor markers for cancer detection. I.
We report a prospective study aimed at assessing the value of serum marker determinations in a supposedly healthy population to detect cancer and to identify individuals at high risk. We analyzed a group of 1,611 supposedly healthy subjects attending a cancer detection center, over a 1-5 year period and a control group of 100 cancer patients. Repeated determinations of the following markers were made: CEA, AFP, HCG, beta-HCG, beta 2-M, ferritin, beta 1-SP, all by radioimmunoassay. In the literature, marker determinations are considered not to be useful for cancer screening; in spite of this, we determined "normal" and "suspicious" levels for each marker and were able to define a group "at risk" that may harbor an early cancer (representing 23.6% of the total) and a "normal" group. The cancer detection rate was 45 0/00 (17/378) in the risk group and 3.2 0/00 in the "normal" one (4/1233). Our data show that markers could play a role in cancer screening.
D000328:Adult; D000367:Age Factors; D002272:Carcinoembryonic Antigen / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis*; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking; D000509:alpha-Fetoproteins / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D000509:alpha-Fetoproteins; D001613:beta 2-Microglobulin; D005293:Ferritins