The effect of pentosanpolysulphate and carbenoxolone on bacterial adherence to the injured urothelium.
The effect of the glycosaminoglycan (GAG) layer on the adherence of Escherichia coli to the bladder urothelium of rats has been studied. The study was performed by destroying the GAG layer and the changes were observed using the electron microscope. Bacterial adherence to the bladder with a destroyed GAG layer was much higher than to the normal bladder. Following the destruction of the GAG layer, the instillation of sodium pentosanpolysulphate significantly reduced the adhesion of bacteria. Prophylactic intramuscular administration of carbenoxolone increased the speed of regeneration of the destroyed GAG layer.
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002229:Carbenoxolone / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology* / Q000648:ultrastructure
D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester; D002229:Carbenoxolone; D006034:Glycyrrhetinic Acid