Effects of capsaicin on release of substance P-like immunoreactivity and physiological parameters in isolated perfused guinea-pig heart.
Release of substance P-like immunoreactivity (SP-LI) was measured from isolated perfused guinea-pig hearts. Capsaicin (1 microM) caused a substantial increase in the amount of SP-LI detected in perfusate compared to values during exposure to vehicle or drug-free buffer. Tachyphylaxis developed to the effect of capsaicin on release of SP-LI and to its effect on physiological parameters. These data show SP-LI can be released from cardiac sensory nerves and suggest SP could mediate a portion of the response of the isolated heart to capsaicin.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010477:Perfusion; D013373:Substance P / Q000276:immunology / Q000378:metabolism*
D013373:Substance P; D002211:Capsaicin