[ATP-activated ion conductance in isolated smooth muscle cells of the urinary bladder of the guinea pig].
Smooth muscle cells of guinea pig urinary bladder were investigated by the intracellular perfusion and voltage clamp techniques. The application of ATP in concentration over 3.10(-8) mol/l elicited fast inward current. ADP, alpha, beta-methylene ATP and beta, gamma-methylene ATP had the similar effect. GTP, ITP, AMP and adenosine elicited no ionic current. AMP was a competitive blocker for receptors of ATP. No pharmacological distinctions were discovered between these receptors and ATP receptors of sensory neurons of the rat. ATP receptors had a fast desensitisation and extremely slow recovery of sensitivity to agonists. The rate of desensitisation decreased with the ATP concentration reduction.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D006168:Guinea Pigs; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*
D007473:Ion Channels; D000255:Adenosine Triphosphate
ATF-aktiviruemaia ionnaia provodimost' v izolirovannykh gladkomyshechnykh kletkakh mochevogo puzyria morskoĭ svinki.