[Anti-cancer efficacy of peplomycin, adsorbed on activated carbon particles, against lymph node metastases in mice].
PEP-CH is comprised of activated carbon particles that adsorb peplomycin. Mice which were inoculated with 5 x 10(5) MH 134 tumor cells subcutaneously opposite the foot-pad of the left hind paw on day 0, received a subcutaneous injection of peplomycin, 0.25 mg/mouse, in the form of PEP-CH or a peplomycin aqueous solution administered at the foot-pad of the left hind paw on day 10. The left popliteal lymph nodes then were transferred intraperitoneally to normal mice on day 14. In the PEP-CH group, the survival time of the recipients was statistically and significantly long, and the transferred tumor cell number, estimated with a calibration curve, was markedly small when compare to mice in the other treatment groups.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage*; D002244:Carbon / Q000008:administration & dosage; D002455:Cell Division; D002470:Cell Survival; D003692:Delayed-Action Preparations; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D017663:Peplomycin
D003692:Delayed-Action Preparations; D001761:Bleomycin; D017663:Peplomycin; D002244:Carbon