title: Estrogen staining in breast carcinoma by PAP methods compared to CEA and ferritin staining.
abstract: The aims of this paper are to demonstrate the stainability of estrogen, CEA, and ferritin in breast carcinomas, fibroadenomas, and fibrocystic diseases; to examine whether the findings of endogenous estrogen using the immunohistochemical detection method are related to estrogen receptor (ER) assays; and to determine whether the stainability of estrogen, CEA, and ferritin were related to the prognosis of breast carcinomas. In breast cancer, the stainability of estrogen using the peroxidase-antiperoxidase (PAP) method was positively correlated with the dextran-coated charcoal (DCC) assay for ER. In breast cancers, the percentage of positive staining was 46% for estrogen, 48% for CEA, and 47% for ferritin. With all three stains, significant differences were observed between cancer and benign diseases. Cases that were both positive for estrogen staining and negative for CEA showed a good prognosis after the recurrence of disease. Our data suggest that the immunohistochemical staining of estrogen, CEA, and ferritin might predict the biological behavior of breast carcinomas and be a prognostically useful indicator of breast cancer patients.
mesh_terms: D000232:Adenofibroma / Q000032:analysis; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis* / Q000401:mortality; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis* / Q000401:mortality; D004967:Estrogens / Q000032:analysis*; D005260:Female; D005293:Ferritins / Q000097:blood*; D005348:Fibrocystic Breast Disease / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D013194:Staining and Labeling
chemical_list: D002272:Carcinoembryonic Antigen; D004967:Estrogens; D005293:Ferritins