title: Immunological similarities between an experimental autoimmune myasthenia gravis model and human myasthenia gravis.
abstract: The induction of experimental autoimmune myasthenia gravis (EAMG) in rabbits after immunization with an acetylcholine (ACh) conjugate was found to possess immunological similarities with human myasthenia gravis. Anti-ACh antibodies, present in human sera, recognized the antigenic determinant, glutarylcholine, used to raise anti-ACh antibodies in rabbits. Identification of anti-anti-ACh antibodies in MG patients enabled us to test for recognition of the anti-ACh antibodies present in rabbit sera. The reverse, the recognition of rabbit auto-anti-anti-ACh antibodies by human anti-ACh antibodies was also tested and found to be specific.
mesh_terms: D000109:Acetylcholine / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies; D004195:Disease Models, Animal; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000276:immunology
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D011950:Receptors, Cholinergic; D000109:Acetylcholine