Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011725:Pyridines / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis*; D016559:Tacrolimus
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011725:Pyridines; D016559:Tacrolimus