Modulation of monocyte complement synthesis by interferons.
Recombinant Escherichia coli-derived gamma-interferon has been shown to stimulate synthesis of the second component of complement (C2), factor B and C1 inhibitor, but to inhibit synthesis of the third component (C3). alpha- and beta-interferons stimulate synthesis of factor B and C3 inhibitor, inhibit C5 synthesis but do not alter synthesis of C2. alpha- and beta-interferons act synergistically with gamma-interferon to enhance both factor B and C1-inhibitor synthesis.
D002478:Cells, Cultured; D011232:Chemical Precipitation; D011415:Complement Factor B / Q000096:biosynthesis; D003165:Complement System Proteins / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*
D007370:Interferon Type I; D007371:Interferon-gamma; D003165:Complement System Proteins; D007372:Interferons; D011415:Complement Factor B