[Common features of the antigenic determinants presented on the membranes of mammalian nervous system cells and cytoplasmic tetrodotoxin-sensitive proteins].
Hypothetical antigenic similarities between nerve cell membrane structures and cytoplasmic tetrodotoxin-sensitive proteins have been studied. Indirect ELISA binding assay combined with inhibition assay has been used. The results obtained indicate that cytoplasmic tetrodotoxin-sensitive proteins do share antigenic determinants with nerve cell membrane structures. This is consistent with the speculation that cytoplasmic tetrodotoxin-sensitive proteins are relatives of membrane sodium channels.
D000818:Animals; D001921:Brain / Q000276:immunology; D002417:Cattle; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D000939:Epitopes / Q000032:analysis*; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009447:Neuroblastoma; D009474:Neurons / Q000276:immunology*; D051381:Rats; D013574:Synaptosomes / Q000276:immunology; D013779:Tetrodotoxin / Q000494:pharmacology*
D000939:Epitopes; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D013779:Tetrodotoxin
Obshchnost' antigennykh determinant, predstavlennykh na membranakh kletok nervnoĭ sistemy mlekopitaiushchikh i na tsitoplazmaticheskikh tetrodotoksinchuvstvitel'nykh belkakh.