title: Immunologic studies of subjects with asthma exposed to formaldehyde and urea-formaldehyde foam insulation (UFFI) off products.
abstract: There has been concern in recent years as to the health hazards of exposure to potentially carcinogenic or immunotoxic substances in the environment. This study was done to determine the effects of exposure to urea-formaldehyde foam insulation (UFFI) off products on various hematologic and immunologic parameters in subjects with asthma: complete blood count and differential, erythrocyte sedimentation rate, lymphocyte subpopulations (E-rosetting, T3, T4, T8, B73.1, and Fc receptor positive lymphocytes and large granular lymphocytes), lymphocyte response to phytohemagglutinin and formalin-treated red blood cells (Form-RBC), serum antibody against the Thomsen-Friedenreich RBC antigen and against Form-RBC, and natural killer (NK), interferon (IFN)-boosted NK (IFN-NK), and antibody-dependent cell-mediated cytotoxicity. Four control subjects with asthma from conventionally insulated homes (control group) and 23 subjects with asthma from UFFI-insulated homes (home group) were exposed to placebo, formaldehyde, dust, and UFFI off gas at levels ordinarily found in UFFI-containing homes for four separate periods in an environmental chamber. Immunologic testing was carried out before the exposure series and 1 day after completion 7 days later as part of an investigation of respiratory and possible allergic effects of such exposure. Data from the UFFI-insulated home group were not significantly different from data of the normal conventionally insulated home control group for any of the variables studied, either before or after UFFI exposure. Paired t tests comparing data from each of the two groups before and after UFFI exposure demonstrated minimal but statistically significant increases in percent eosinophils and T8 positive cells in the UFFI-insulated home group only. Although NK, relative NK, and IFN-NK were normal in all groups, IFN-NK assays by use of a low concentration of alpha-interferon demonstrated a statistically significant decrease in NK response to IFN in both the control and UFFI-insulated home groups after UFFI exposure. These differences were not observed at optimum levels of IFN stimulation. These data indicate that long-term exposure to UFFI off products in the home apparently had no effect on the immunologic parameters studied. Short-term exposure resulted in minor immunologic changes in this subject population.
mesh_terms: D000917:Antibody Formation; D015295:Antigens, Tumor-Associated, Carbohydrate; D001249:Asthma / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004187:Disaccharides / Q000032:analysis; D005557:Formaldehyde / Q000009:adverse effects*; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000145:classification; D012882:Skin Tests; D014508:Urea / Q000009:adverse effects
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; D005557:Formaldehyde; C016467:Thomsen-Friedenreich antigen; D014508:Urea; D007372:Interferons