[Structural damages and DNA synthesis in bone marrow and peripheral blood cells in myelodepression induced by cytostatic preparations].
Some structural and functional indices of the genome state of rat myelopoietic cells after cytostatic ingestion are studied by the immunofluorescent method and by 3H-thymidine incorporation. It is shown that administration of cyclophosphamide causes structural and functional damages of hemopoietic cells. It is suggested that the intensity of repair potentials is a leading factor in restoration of depressed hemopoiesis.
D000818:Animals; D001773:Blood Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001854:Bone Marrow Cells; D002452:Cell Count / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D004249:DNA Damage; D003864:Depression, Chemical; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012107:Research Design; D005719:gamma-Globulins / Q000494:pharmacology
D005719:gamma-Globulins; D003520:Cyclophosphamide; D004247:DNA
Strukturnye povrezhdeniia i sintez DNK v kletkakh kostnogo mozga i perifericheskoĭ krovi pri mielodepressii, vyzvannoĭ tsitostaticheskimi preparatami.