title: On the mechanism of dextran-induced histamine secretion from rat peritoneal mast cells.
abstract: The mechanism of histamine release induced from isolated rat peritoneal mast cells by clinical dextran was examined in detail. The putative involvement of cell-fixed IgE antibodies in the process was discounted by a number of experimental approaches. Instead, the characteristics of the release were found to be consistent with the interaction of the polysaccharide with specific glucoreceptors on the mast cell membrane.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D003911:Dextrans / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects; D013268:Stimulation, Chemical
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D003911:Dextrans; D011956:Receptors, Cell Surface; C027786:glucose receptor; D007073:Immunoglobulin E