Metabolism of monoamines in the brain after total hepatectomy in the rat.
Rats were subjected to total hepatectomy or a sham operation and infused 5 h with 10% glucose solution. The metabolism of indoleamines and catecholamines was studied in five regions of the brain and two regions of the spinal cord by using a decarboxylase inhibitor (NSD 1015) blocking the conversion of 5-hydroxytryptophan (5-HTP) to serotonin and DOPA to dopamine. In the brain the concentrations of 5-HTP, serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) were elevated in all regions compared with controls except for serotonin in the mesencephalon-pons. In the spinal cord the concentrations of 5-HIAA were elevated whereas the concentrations of 5-HTP and serotonin were unchanged. The concentrations of DOPA were increased in the mesencephalon-pons whereas those of norepinephrine were decreased in cortex and mesencephalon-pons compared with controls. The results suggest an increased synthesis rate of the indoleamines in the brain and probably also of the catecholamines in the mesencephalon-pons at 5 h after hepatectomy.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006498:Hepatectomy; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D014018:Tissue Distribution
D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D005947:Glucose; D004298:Dopamine; D009638:Norepinephrine