Fibrosis of tunica albuginea: complication of long-term intracavernous pharmacological self-injection.
We report 3 cases of penile curvature deformity and fibrosis of the tunica albuginea after long-term self-injection with papaverine hydrochloride and phentolamine mesylate. To our knowledge this complication has not been reported previously. The clinical presentation and possible etiology are discussed.
D000368:Aged; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy*; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000009:adverse effects* / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects; D010411:Penile Induration / Q000139:chemically induced*; D010413:Penis / Q000473:pathology; D010646:Phentolamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012646:Self Administration; D013997:Time Factors
D004338:Drug Combinations; D010208:Papaverine; D010646:Phentolamine