Single acetylcholine-activated channels in cultured rhabdomyoblasts.
Acetylcholine receptor (AChR) was found to be present on the cell surface of the human rhabdomyoblast (RD) cell line. Two classes of ACh-activated channels have been observed, one with a large conductance and long duration and the other with smaller conductance and short duration, similar to those of human myotubes. RD membrane exhibited a specific binding to the alpha-bungarotoxin indicating the presence of nicotinic AChRs. These results support the hypothesis that rhabdomyosarcomas derive from myogenic precursors.
D002038:Bungarotoxins / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D004594:Electrophysiology; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D011950:Receptors, Cholinergic / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology; D012208:Rhabdomyosarcoma / Q000503:physiopathology*
D002038:Bungarotoxins; D007473:Ion Channels; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic