Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.
Hypertensive action was observed in conscious rats injected intraventricularly with glandular kallikrein (EC 3.4.21.35) in a dose-dependent manner (4-16 KU), which was associated with the enhancement of brain kinin level. Concurrently administered aprotinin, a kallikrein inhibitor, led to an inhibition of these effects of kallikrein. These results suggest that the central hypertensive action of kallikrein is mediated via the kinin liberated from a kininogen in the brain.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D007276:Injections, Intraventricular; D007610:Kallikreins / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D007705:Kinins; D007611:Aprotinin; D007610:Kallikreins