The effects of cinepazide on the content, biosynthesis and turnover of noradrenaline, dopamine and 5-hydroxytryptamine in the rat brain under room air and hypoxia.
The effects of cinepazide, a vasodilator, on the content, biosynthesis and turnover of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) in the rat brain were examined under room air and hypoxia (10% O2, 90% N2). Under room air, cinepazide had no significant effects on the content of NA, DA, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA), the accumulation of 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) after central decarboxylase inhibition, and the depletion of NA, DA and 5-HT after synthesis inhibition. After 2 hr-exposure to hypoxia, the content of NA, 5-HT and 5-HIAA was decreased, whereas the content of DA was unchanged. The accumulation of DOPA and 5-HTP was decreased. The depletion of DA and 5-HT was inhibited by hypoxia, whereas the depletion of NA was unaffected. Under hypoxic conditions, cinepazide had no effects on the content of NA, DA and 5-HT, the accumulation of DOPA and 5-HTP, and the depletion of NA and DA, whereas cinepazide increased both the rate of 5-HT depletion and the content of 5-HIAA. The present data suggest that cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D006900:Hydroxylation; D000860:Hypoxia / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology*
D010879:Piperazines; D014665:Vasodilator Agents; D012701:Serotonin; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D004295:Dihydroxyphenylalanine; C026896:cinepazide; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D004298:Dopamine; D009638:Norepinephrine