Characterization of Hantaviruses using monoclonal antibodies.
The antigenic relations among nine Hantaviruses from seven different geographic areas were examined in indirect fluorescent antibody test with 12 monoclonal antibodies. Ten monoclonals were prepared against Hantaan virus strain 76-118 and two against Hantavirus B-1, a virus isolated from a tumour in a laboratory rat. Four different serotypes have been differentiated: Hällnäs, Hantaan, Prospect Hill and Rat strain like. Two monoclonal antibodies were able to react with all nine Hantaviruses studied. Rat strain- and Hantaanvirus-specific monoclonal antibodies were documented.
D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000032:analysis*; D002043:Bunyaviridae / Q000145:classification / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006476:Orthohantavirus / Q000276:immunology*; D006801:Humans; D051381:Rats; D012703:Serotyping; D014709:Vero Cells
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes