[New findings on the mechanism of action of blocking toxins on electrically excitable sodium channels].
The paper summarizes the results obtained from the 10-12 years studies on the mechanism of action of blocking toxins--tetrodotoxin (TTX) and saxitoxin (STX)--on voltage-operated sodium channels. Experimental data can be interpreted on the basis of two models of blocking action of toxins: channel blockade, when guanidine group of toxins penetrates into the channel and causes its blockade and allosteric action on sodium conductance. Special attention is devoted to peculiarities of cooperative interaction between the blockers and channels. The analysis of experimental findings permits a better understanding of functional organization of sodium channels, in particular, the interrelation between the receptor of blocking toxins and its other structural elements.
D000818:Animals; D003864:Depression, Chemical; D004594:Electrophysiology; D006571:Heterocyclic Compounds / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*; D012995:Solubility; D014118:Toxins, Biological / Q000494:pharmacology*
D006571:Heterocyclic Compounds; D007473:Ion Channels; D011955:Receptors, Drug; D014118:Toxins, Biological; D012964:Sodium
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