Macroamylasemia associated with thyroid cancer, elevated serum thyroxine-binding globulin (TBG), chronic pancreatitis and gastrointestinal polyposis.
A case of macroamylasemia in a 78 year-old female, associated with papillary adenocarcinoma of the thyroid and elevated serum thyroxine-binding globulin was described. Serum amylase of the patient was very high despite a normal level of serum lipase. Her serum amylase was characterized as macroamylase on the basis of electrophoresis and elution profile of gel chromatography. Serum precipitation response using chain-specific rabbit anti-human IgG, IgA and IgM antisera disclosed that her macroamylase was mainly composed of immune complexes between amylase and IgA class anti-amylase antibodies. Both the pathogenesis and clinical significance of the association of these disorders in this patient were discussed.
D000231:Adenocarcinoma, Papillary / Q000201:enzymology* / Q000276:immunology; D000368:Aged; D000681:Amylases / Q000097:blood*; D000936:Antigen-Antibody Complex / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D009378:Neoplasms, Multiple Primary; D010195:Pancreatitis / Q000150:complications; D011127:Polyps / Q000201:enzymology; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000276:immunology; D013975:Thyroxine-Binding Proteins / Q000032:analysis*
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D013975:Thyroxine-Binding Proteins; D000681:Amylases; C001663:macroamylase