title: Regional distant sequence homology between amylases, alpha-glucosidases and transglucanosylases.
abstract: Amylases possess short, conserved regions near functional side chains. Sequence comparison extends this relationship to comprise a maltase and a cyclodextrin glucanotransferase. Similarity also exists with intestinal sucrase-isomaltase and fungal glucoamylase near identified essential carboxyl groups. Homology between COOH-terminal regions of glucoamylase and cyclodextrin glucanotranserase may indicate raw-starch binding areas. It is suggested that amylases, alpha-glucosidases, and transglucanosylases acting on 1,4- and 1,6-alpha-glucosidic linkages share key structural features in the active centres.
mesh_terms: D015061:1,4-alpha-Glucan Branching Enzyme; D000595:Amino Acid Sequence; D000681:Amylases; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D001665:Binding Sites; D004331:Drosophila melanogaster / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D005087:Glucan 1,4-alpha-Glucosidase; D005964:Glucosyltransferases; D006004:Glycogen Debranching Enzyme System; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009834:Oligo-1,6-Glucosidase; D010944:Plants / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013393:Sucrase; D013552:Swine; D000516:alpha-Amylases; D000520:alpha-Glucosidases
chemical_list: D006004:Glycogen Debranching Enzyme System; D005964:Glucosyltransferases; D015061:1,4-alpha-Glucan Branching Enzyme; C019963:cyclomaltodextrin glucanotransferase; C020569:4 alpha-glucanotransferase; D000681:Amylases; D000516:alpha-Amylases; D009834:Oligo-1,6-Glucosidase; D000520:alpha-Glucosidases; D005087:Glucan 1,4-alpha-Glucosidase; D013393:Sucrase