Palisades in primary cerebral neuroblastoma simulating so-called polar spongioblastoma. A light and electron microscopical study of an adult case.
A frontal lobe neoplasm in a 25-year-old Caucasian man showed the typical histological pattern of a "polar spongioblastoma." Immunoperoxidase staining for glial fibrillary acidic protein (GFAP) was negative while silver stains in paraffin-embedded tissue, and electron microscopy displayed neoplastic cells with neuritic processes. Ultrastructurally there were microtubules, synapses and dense-core neurosecretory granules, all features of a neuroblastic neoplasm. It is suggested that this new growth with its polar spongioblastic appearance is, in fact, a moderately malignant primary cerebral neuroblastoma.
D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis; D001932:Brain Neoplasms / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000175:diagnosis / Q000648:ultrastructure*; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed