The neurotoxic actions of 6-hydroxydopamine infused into the rat substantia nigra.
6-Hydroxydopamine (6-OHDA) 10 and 40 micrograms/24 h infused bilaterally for 4 days into the rat substantia nigra (SN) caused a 'freezing' akinetic response which was apparent within 24 h and which persisted throughout the period of infusion. The infusion of 10 or 40 micrograms/24 h 6-OHDA into the SN failed to cause any change in motor coordination, or induce limb and body rigidity. The infusion of 40 micrograms/24 h 6-OHDA led to significant reductions in the striatal levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and noradrenaline; no changes were observed following the 4-day infusion of 10 micrograms 6-OHDA. The consequences of infusing 6-OHDA into the SN are discussed in relation to those induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) where the spectrum of behavioural and biochemical change caused by 6-OHDA is shown not to mimic the actions of either MPTP or MPP+.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium; D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D006719:Homovanillic Acid / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced*; D018377:Neurotransmitter Agents / Q000032:analysis; D016627:Oxidopamine; D011725:Pyridines / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*
D006892:Hydroxydopamines; D018377:Neurotransmitter Agents; D011725:Pyridines; D011726:Pyridinium Compounds; D015102:3,4-Dihydroxyphenylacetic Acid; D006897:Hydroxyindoleacetic Acid; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium; D006719:Homovanillic Acid