Inhibitors of coagulation-fibrinolysis system and platelet function in patients with vertigo.
Eight parameters of blood coagulation and fibrinolysis, i.e., the levels of fibrinogen, plasminogen, fibrinogen and/or fibrin-degradation products (FDP), alpha 2-macroglobulin, alpha 1-antitrypsin, CI-inactivator, antiplasmin activity and antithrombin activity, were measured in patients with vertigo. Furthermore, the ADP- and collagen-induced platelet aggregations were determined. The results were compared with those for healthy adults. The antiplasmin activity was significantly reduced (p is less than 0.001), the antithrombin activity was significantly reduced (p is less than 0.001) and the platelet aggregation significantly increased (p is less than 0.001), but the levels of fibrinogen, plasminogen, FDP, alpha 2-macroglobulin, alpha 1-antitrypsin and CI-inactivator were not significantly altered. The importance of the coagulation-fibrinolysis system and platelet function in patients with vertigo is discussed.
D000991:Antithrombins / Q000032:analysis; D001777:Blood Coagulation; D003174:Complement C1 Inactivator Proteins / Q000032:analysis; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000032:analysis; D010974:Platelet Aggregation; D014717:Vertigo / Q000097:blood* / Q000503:physiopathology; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000979:alpha-2-Antiplasmin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000991:Antithrombins; D003174:Complement C1 Inactivator Proteins; D005338:Fibrin Fibrinogen Degradation Products; D000515:alpha 1-Antitrypsin; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; D005340:Fibrinogen; D010958:Plasminogen