The effect of the anabolic agent, clenbuterol, on overloaded rat skeletal muscle.
The dietary administration of clenbuterol to young male rats has been shown to produce a muscle specific hypertrophic growth response. This paper demonstrates that the combined effect of drug treatment and hypertrophic stimulus induced by tenotomy produced an additive effect on muscle growth. This effect was demonstrated in terms of both muscle composition (protein and RNA) and fibre size.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D006614:Hindlimb; D006984:Hypertrophy; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012313:RNA / Q000378:metabolism; D051381:Rats; D013314:Stress, Mechanical; D013710:Tendons / Q000601:surgery
D004983:Ethanolamines; D009124:Muscle Proteins; D012313:RNA; D000252:Calcium-Transporting ATPases; D002976:Clenbuterol