title: The patch clamp is more useful than anyone had expected.
abstract: The patch clamp was developed into its present form by Neher and Sakmann for recording the currents through individual ionic channels in excitable membranes. Recent advances now allow the patch-clamp technique to be used to record from cell-free membrane patches and from entire small cells. The technique has been used extensively for recordings from single channels that have provided new insights into their functioning; it is also being applied to a surprising variety of other physiological problems.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology*; D005089:Exocytosis; D007473:Ion Channels / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology
chemical_list: D007473:Ion Channels; D011950:Receptors, Cholinergic