title: Dynorphin B-containing perivascular axons and sensory neurotransmitter mechanisms in brain blood vessels.
abstract: This is the first report demonstrating the existence of opiate-containing nerve fibers surrounding brain blood vessels. Dynorphin B, a tridecapeptide and potent opiate analgesic, was visualized by immunohistochemistry in guinea pig cerebral arteries comprising the circle of Willis and was measured by radioimmunoassay in canine middle cerebral arteries. This peptide, reportedly present in dorsal root ganglion cells, was observed by others to decrease the depolarization-induced release of substance P from primary sensory axons and, by so doing, to retard the development of neurogenic inflammation in target tissues. Consistent with an indirect action of dynorphin B, this peptide did not relax precontracted canine middle cerebral or basilar artery segments when added in vitro, nor did it modulate receptor-mediated relaxation on the addition of substance P. The presence of opiate-containing axons in or near trigeminovascular nerve fibers suggests novel mechanisms related to the modulation of pain possibly emanating from cerebral vessels.
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000294:innervation; D001369:Axons / Q000378:metabolism*; D001488:Basilar Artery / Q000187:drug effects / Q000294:innervation; D001839:Bombesin / Q000494:pharmacology; D001921:Brain / Q000098:blood supply*; D002339:Carotid Arteries / Q000187:drug effects; D002531:Cerebellum / Q000098:blood supply; D002536:Cerebral Arteries / Q000294:innervation; D002941:Circle of Willis / Q000294:innervation; D004285:Dogs; D004399:Dynorphins / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D004723:Endorphins / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D009475:Neurons, Afferent / Q000378:metabolism; D018377:Neurotransmitter Agents; D010841:Pia Mater / Q000098:blood supply; D013004:Somatostatin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D014276:Trigeminal Nerve / Q000378:metabolism
chemical_list: D004723:Endorphins; D018377:Neurotransmitter Agents; D013373:Substance P; D013004:Somatostatin; D004399:Dynorphins; C036200:rimorphin; D001839:Bombesin