Influence of fibrinolysis activation on leukocyte adhesiveness. Preliminary report.
In patients with thrombophlebitis receiving intravenously a nicotinic acid derivative, pentoxifylline and streptokinase the fibrinolytic activity and leukocyte adhesiveness were studied. The euglobulin lysis time was significantly shortened in all cases; at the same time the adhesiveness of leukocytes and the leukocyte number were reduced. The addition of the drugs to blood in vitro resulted in a significant increase in leukocyte adhesiveness; the fibrinolytic activity was enhanced only upon streptokinase. Leukocytes are believed to promote the thrombolytic effect of fibrinolytic agents.
D000328:Adult; D002448:Cell Adhesion / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000627:therapeutic use*; D010431:Pentoxifylline / Q000627:therapeutic use*; D013300:Streptokinase / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*; D013924:Thrombophlebitis / Q000097:blood* / Q000188:drug therapy
D009243:NAD; D013300:Streptokinase; D013805:Theobromine; D010431:Pentoxifylline