Comparison of bleomycin and peplomycin toxicity on clonogenic tumor cells from various human tumors.
The cytotoxic effect of bleomycin and peplomycin was compared using a methylcellulose monolayer assay for the cultivation of human tumor cells. In 3 out of 4 samples from human malignant melanomas peplomycin proved to be more cytotoxic than bleomycin. Peplomycin was more cytotoxic than bleomycin in 1 of 5 myosarcoma samples, whereas 2 samples from squamous cell carcinomas of the lung showed identical dose response curves. In 1 carcinoma of the gall bladder peplomycin was more toxic than bleomycin.
D001761:Bleomycin / Q000494:pharmacology*; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000473:pathology; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008545:Melanoma / Q000473:pathology; D009217:Myosarcoma / Q000473:pathology; D017663:Peplomycin; D014410:Tumor Stem Cell Assay; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D001761:Bleomycin; D017663:Peplomycin