title: Molecular genetics of the VDAC ion channel: structural model and sequence analysis.
abstract: The voltage-dependent anion-selective channel of the outer mitochondrial membrane provides a unique system in which to study the molecular basis of voltage gating of ion flow. We have cloned and sequenced a cDNA coding for this protein in yeast. From the derived amino acid sequence, we have generated a preliminary model for the secondary structure of the protein which suggests that the protein forms a "beta-barrel" type structure. Comparison of the VDAC amino acid sequence with that of the bacterial porins has indicated that the two classes of molecules appear to be unrelated.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005796:Genes; D005800:Genes, Fungal; D007473:Ion Channels / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics*; D008928:Mitochondria / Q000502:physiology*; D018272:Porins; D012441:Saccharomyces cerevisiae / Q000235:genetics; D050994:Voltage-Dependent Anion Channels
chemical_list: D007473:Ion Channels; D008565:Membrane Proteins; D018272:Porins; D050994:Voltage-Dependent Anion Channels