Immunohistochemical study on regeneration of substance P-like immunoreactivity in rat molar pulp and periodontal ligament following resection of the inferior alveolar nerve.
Using an indirect immunofluorescence method, after 14 days, regenerated SP-containing nerve fibres first appeared around the blood vessels in apical and coronal regions of the pulp and apical and middle regions of the periodontal ligament. Penetration of regenerated SP-positive fibres into the dentine and predentine was observed 25 days after operation. The number of regenerated SP-containing fibres recovered to nearly to the same level as in intact controls by 35 days. They had a similar distribution in the tissues.
D000818:Animals; D003782:Dental Pulp / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D008297:Male; D008340:Mandibular Nerve / Q000502:physiology* / Q000601:surgery; D009412:Nerve Fibers / Q000502:physiology; D009416:Nerve Regeneration; D010513:Periodontal Ligament / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*
D013373:Substance P