title: [Demonstration of a large-conduction ion channel in subcellular fractions of the adrenal medulla].
abstract: The "tip-dip" technique (formation of a lipid bilayer at the tip of a microelectrode) allows the electrophysiological study of organelle membranes. An ionic channel of large conductance has been found by this technique in membrane preparations from adrenal medulla. This channel is voltage-sensitive and it has 4 levels of conductance. Its subcellular origin is to be determined; it is borne by a structure which sediments between 1,500 and 25,000 X g.
mesh_terms: D000313:Adrenal Medulla / Q000648:ultrastructure*; D000818:Animals; D002417:Cattle; D002498:Centrifugation; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D013347:Subcellular Fractions / Q000032:analysis / Q000502:physiology*
chemical_list: D007473:Ion Channels
vernacular_title: Mise en évidence d'un canal ionique de grande conductance dans des fractions sub-cellulaires de la médullo-surrénale.