Interaction of bradykinin with substance P on vascular permeability and pain response.
Combination of bradykinin with substance P exerted synergistic effects on vascular permeability and pain response in mouse paw. Denervation of sciatic nerve reduced significantly bradykinin-induced vascular permeability, suggesting the involvement of sensory nerves. The bradykinin-induced vascular permeability was also reduced by intravenous injection of a substance P-antagonist. The results suggest that neuronal substance P takes part in the action of bradykinin on inflammation and pain sensation.
D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage*; D002199:Capillary Permeability / Q000187:drug effects*; D004357:Drug Synergism; D005528:Foot; D007249:Inflammation / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced* / Q000503:physiopathology; D013373:Substance P / Q000008:administration & dosage*
D013373:Substance P; D001920:Bradykinin