The perivascular cell populations in human skin after topical application of leukotriene B4.
Fifteen timed biopsies of human skin were performed after application of 100 nanograms of leukotriene B4 in a Finnchamber for six hours. The number of inflammatory cells were counted per high power perivascular field and compared to three control biopsies. At 24 hours a peak of neutrophiles was observed and subsequently lymphocytes predominated. Eosinophils were never prominent. This pattern of successive cell populations has been described in inflammatory and whealing skin disease.
D000287:Administration, Topical; D001706:Biopsy; D004804:Eosinophils; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007958:Leukocyte Count; D007975:Leukotriene B4 / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D008214:Lymphocytes; D009504:Neutrophils; D012867:Skin / Q000473:pathology*; D013997:Time Factors
D007975:Leukotriene B4