[Effect of alpha 2-macroglobulin on indices of the proteolysis system and organ blood flow in tourniquet shock].
It was shown that alpha 2-macroglobulin (50 mg/kg, 30 min before revascularization of previously ischemized extremities) significantly inhibits the blood serum proteolytic activity and exerts similarly to contrykal (10,000 U/kg) the correcting effect on the level of arterial blood pressure and parameters of the blood flow in the kidneys, intestine and previously ischemized extremities.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D002415:Cats; D004353:Drug Evaluation, Preclinical; D006614:Hindlimb / Q000098:blood supply; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012769:Shock / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D013997:Time Factors; D014111:Tourniquets; D000511:alpha-Macroglobulins / Q000627:therapeutic use*
D000511:alpha-Macroglobulins; D007611:Aprotinin; D010447:Peptide Hydrolases
Vliianie al'fa 2-makroglobulina na pokazateli sistemy proteoliza i organnogo krovotoka pri turniketnom shoke.