Scorpion venom inhibits selectively Ca2+-activated K+ channels in situ.
Using patch-clamp techniques, a study was made of the component of Leiurus quinquestriatus scorpion venom which caused a blockade of one class of membrane potassium channels, the calcium activated potassium (BK) channels. This blockade was obtained on channels in their native lipidic environment and was specific for this class of channels as other types of potassium channels were not affected by this venom.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002460:Cell Line; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D012604:Scorpion Venoms / Q000633:toxicity*; D013724:Teratoma
D007473:Ion Channels; D012604:Scorpion Venoms; D011188:Potassium; D002118:Calcium