Interference with the distribution and release of arachidonic acid in human keratinocytes by bradykinin, histamine and phosphatidic acid.
The effects of bradykinin, histamine, phosphatidic acid and leukotrienes B4 and C4 on the distribution and release of 14C-arachidonic acid in human keratinocytes in culture were investigated. Bradykinin, histamine, and phosphatidic acid were found to liberate 14C-arachidonic acid from membrane phospholipids, whereas leukotrienes B4 and C4 were ineffective in this respect. The decrease in the labeling of phospholipids was accompanied by increased labeling of the non-phosphorus lipids. The present study suggests that bradykinin, histamine, and phosphatidic acid may interfere with the distribution and release of arachidonic acid in human keratinocytes in culture.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D007975:Leukotriene B4 / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology
D001095:Arachidonic Acids; D010712:Phosphatidic Acids; D010743:Phospholipids; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D007633:Keratins; D006632:Histamine; D001920:Bradykinin