6-Hydroxydopamine treatment increases beta-adrenoceptors and Ca2+ channels in rat heart.
Rats received 6-hydroxydopamine (50 mg/kg i.v.) on two successive days. After 14 days cardiac beta-adrenoceptors and Ca2+ channels were measured by radioligand binding. Ca2+ channel binding [( 3H]nitrendipine) was increased 31% with no change in affinity, and beta-adrenoceptor binding [( 3H]dihydroalprenolol) was increased 28% with no change in affinity. Innervation may be important in the regulation of Ca2+ channel expression.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D006892:Hydroxydopamines / Q000494:pharmacology*; D007473:Ion Channels / Q000032:analysis*; D008297:Male; D009206:Myocardium / Q000032:analysis; D016627:Oxidopamine; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D006892:Hydroxydopamines; D007473:Ion Channels; D011943:Receptors, Adrenergic, beta; D016627:Oxidopamine; D002118:Calcium