[Morphometric characteristics of argentaffin nucleolar structures in peripheral blood lymphoid cells from patients with non-Hodgkin's lymphomas and chronic lymphoid leukemias].
Interphase lymphoid nucleoli of Ag-NOR stained site areas were measured on the TAS system in peripheral blood lymphoid cells with the known immunologic phenotype of 19 patients with lymphoid neoplasia (non-Hidgkin's lymphoma, CLL, hair-cell leukemia) and 10 healthy donors. The area of Ag-granules in neoplastic cells is much greater than in normal lymphocytes and does not correlate with a proliferation of cells but correlates with a malignancy grade of the disease. These data are discussed in terms of rDNA transcription patterns in malignant cells.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002455:Cell Division; D002466:Cell Nucleolus / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007620:Karyometry; D007945:Leukemia, Lymphoid / Q000097:blood / Q000473:pathology*; D008214:Lymphocytes / Q000648:ultrastructure*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012834:Silver; D013194:Staining and Labeling
D012834:Silver
Morfometricheskaia kharakteristika argentofil'nykh struktur nukleol limfoidnykh kletok perifericheskoĭ krovi bol'nykh nekhodzhkinskimi limfomami i khronicheskim limfoleĭkozom.