Experimental renal anaphylaxis: release of histamine and study of its effect on renal perfusion.
Antigen challenge of isolated perfused kidneys of sensitized guinea-pigs consistently released a large proportion of their histamine content, and caused a reduction in renal perfusate flow rate (RPFR) which could not simply be due to the released histamine, since much larger amounts of exogenous histamine were needed to produce a comparable effect. Reduction in RPFR by histamine was blocked by mepyramine but not by cimetidine, i.e. it is mediated by an H1-receptor mechanism.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D002927:Cimetidine; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G / Q000276:immunology; D007668:Kidney / Q000503:physiopathology*; D011738:Pyrilamine; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology*; D012079:Renal Circulation / Q000187:drug effects
D007106:Immune Sera; D007074:Immunoglobulin G; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D002927:Cimetidine; D006632:Histamine; D011738:Pyrilamine