Maintenance of cortical somatostatin and monoamine levels in the rat does not require intact cholinergic innervation.
Levels of somatostatin, noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged in rat neocortex 3 or 6 months after ibotenic acid lesion of the ipsilateral nucleus basalis that reduced cortical choline acetyltransferase levels by over 60%. These results render unlikely the possibility that non-cholinergic neurotransmitter deficits in Alzheimer's disease cortex are the consequence of cholinergic degeneration.
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D001679:Biogenic Amines / Q000032:analysis*; D002540:Cerebral Cortex / Q000032:analysis*; D002799:Cholinergic Fibers / Q000502:physiology; D004298:Dopamine / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013004:Somatostatin / Q000032:analysis*; D013377:Substantia Innominata / Q000502:physiology*
D001679:Biogenic Amines; D012701:Serotonin; D013004:Somatostatin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine