Paget's disease of the groin associated with adenocarcinoma of the urinary bladder.
A 70-year-old Caucasian male developed a left groin tumor with epidermal infiltration of Paget's type. Five months later the ureter was found to be obstructed by a bladder adenocarcinoma cytologically identical to the skin lesion. Both tumors contained carcinoembryonic antibodies, using the immunoperoxidase method. Despite radiation therapy, the patient died a month later. There are no previous reports of association between urinary bladder adenocarcinoma and extramammary Paget's disease of the skin.
D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D006119:Groin; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000473:pathology*; D013194:Staining and Labeling; D001749:Urinary Bladder Neoplasms / Q000473:pathology*