title: [Neuroendocrine carcinoma (Merkel cell tumor) in the head and neck area].
abstract: The neuroendocrine carcinoma of the skin has its histogenetic origin in Merkel cells and a preference in head and neck area in the seventh decade of life. The definitive diagnosis can be made with a combination of electron microscopy and immunohistochemistry. Merkel cell carcinoma is a primary cutaneous neoplasma and is rarely found on the lips or gingiva. Operation and radiation are the therapy of choice. The value of an additional antineoplastic chemotherapy in the treatment of Merkel cell carcinoma is still controversial. Although long survival times had been described in literature the occurrence of local relapses and metastases demands for frequent controls.
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008854:Microscopy, Electron; D016900:Neurofilament Proteins; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D007633:Keratins
vernacular_title: Das neuroendokrine Karzinom (Merkelzelltumor) im Kopf-Hals-Bereich.