DNA breaks generated by the bleomycin-iron III complex in the presence of KHSO5, a single oxygen donor.
KHSO5, a water soluble single oxygen donor, is shown to be capable of activating bleomycin-FeIII complex for DNA cleavage. DNA breaks mediated by bleomycin-FeIII in the presence of H2O2 or KHSO5 are compared and the P450-like activation of metallobleomycins is discussed.
D010582:Bacteriophage lambda / Q000235:genetics; D001761:Bleomycin / Q000494:pharmacology* / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004279:DNA, Viral / Q000032:analysis*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism*; D013464:Sulfuric Acids / Q000494:pharmacology*
D004279:DNA, Viral; D013464:Sulfuric Acids; C023503:iron bleomycin; D001761:Bleomycin; D003577:Cytochrome P-450 Enzyme System; D006861:Hydrogen Peroxide; C048813:potassium peroxymonosulfuric acid; D010100:Oxygen