Autoradiographic localization of receptors in the mammalian cardiovascular system.
1. Autoradiographic techniques have been used to examine the location of beta-adrenoceptors in the heart and beta-adrenoceptors, substance P receptors and muscarinic cholinoceptors in blood vessels. 2. Both beta 1-adrenoceptors and beta 2-adrenoceptors were present in guinea-pig and human heart, on the myocardium and associated with the cardiac nerves and blood vessels. 3. Nerves on the vasculature and vascular smooth muscle contained beta-adrenoceptors and muscarinic cholinoceptors. 4. Receptors for substance P and beta-adrenoceptors, but not muscarinic cholinoceptors were present on endothelial cells.
D000818:Animals; D001345:Autoradiography; D002319:Cardiovascular System / Q000032:analysis*; D004285:Dogs; D004730:Endothelium, Vascular / Q000032:analysis*; D006168:Guinea Pigs; D006325:Heart Atria; D006801:Humans; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D011976:Receptors, Muscarinic / Q000032:analysis*; D013373:Substance P / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D013373:Substance P