Surfactant and physiologic alterations in an animal model of adult human lung disease. A preliminary report.
The diffuse obstructive and infiltrative lung diseases (e.g. bronchitis, asthmatic bronchitis, fibrosing alveolitis, sarcoidosis) contribute significantly to human morbidity and mortality. Disturbance of ventilation and perfusion represents a major physiologic defect in these diseases, resulting in pulmonary hypertension, cor pulmonale and right heart failure. Immunologic and surfactant alterations play a prominent role in these diseases. There is a growing body of evidence indicating that surfactant is a most important material in maintaining airway patency. General concepts regarding these functions in human adult lung diseases and results of investigations of surfactant in an animal model of bleomycin-induced lung fibrosis are presented.
D000818:Animals; D001761:Bleomycin; D004195:Disease Models, Animal; D008168:Lung / Q000378:metabolism; D008170:Lung Compliance; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D010743:Phospholipids; D011506:Proteins; D011663:Pulmonary Surfactants; D001761:Bleomycin