Neurologic complications of Semple-type rabies vaccine: clinical and immunologic studies.
We studied 61 patients with complications of Semple-type postexposure rabies immunization. Thirty-six had neurologic signs, and 25 had only fever, headache, or myalgia. Thirty-two patients had CNS complications, and 4 had an acute peripheral neuropathy. Disease was acute and monophasic in 33, but 3 patients had progressive disease, including 1 patient with a relapsing-remitting course. No clinical features, including CSF content of myelin basic protein, were prognostic indicators. In three of six patients with encephalomyelitis, lymphocytes showed a proliferative response to myelin.
D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000209:etiology*; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid / Q000209:etiology*; D011819:Rabies Vaccines / Q000009:adverse effects*
D002556:Cerebrospinal Fluid Proteins; D004676:Myelin Basic Protein; D011819:Rabies Vaccines