Effect of 5'-nucleotidase inhibitors on mouse immune system and experimental murine tumors.
Nucleoticidin and melanocidins A and B exhibited potent inhibitory activity against 5'-nucleotidases from rat liver membrane and snake venom. Nucleoticidin retarded growth of Sarcoma 180 solid tumor, and melanocidins A and B prolonged the survival period of mice bearing B16 melanoma. These inhibitors enhanced phagocytic activity, interleukin-1 production and superoxide-generating activity of murine peritoneal macrophages. The tumor necrosis factor was also induced by the inhibitors. These results suggested that 5'-nucleotidase inhibitors inhibit tumor growth by modification of the immune system.
D015720:5'-Nucleotidase; D000276:Adjuvants, Immunologic; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D007375:Interleukin-1 / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009708:Nucleotidases / Q000037:antagonists & inhibitors*; D011134:Polysaccharides / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000188:drug therapy; D013481:Superoxides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D006023:Glycoproteins; D007375:Interleukin-1; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D007372:Interferons; C047542:nucleoticidin; C046077:melanocidin A; C046078:melanocidin B; D009708:Nucleotidases; D015720:5'-Nucleotidase