Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product.
The expression of v-abl oncogene during the in vitro differentiation of an Abelson-virus-transformed immature B precursor cell line from immunoglobulin-null to intracytoplasmic mu-positive cells and further to intracytoplasmic gamma 2b-positive cells was examined. The results showed no significant alteration in the amounts and tyrosine kinase activity of v-abl oncogene product during differentiation, indicating that B cell differentiation processes are independent of v-abl functions.
D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D007142:Immunoglobulin gamma-Chains / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D051379:Mice; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D009857:Oncogenes; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D011995:Recombination, Genetic; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D007142:Immunoglobulin gamma-Chains; D007148:Immunoglobulin mu-Chains; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D019000:Phosphotyrosine; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases