Production of interleukin-2 and interleukin-2 inhibitor in patients with palmoplantar pustulosis.
We studied production of interleukin-2 (IL-2) and IL-2 inhibitor from peripheral blood of patients with palmoplantar pustulosis (PPP). Nineteen patients were divided into two groups: those with and those without arthro-osteitis. Although IL-2 production in both groups of patients was within normal limits, those with arthro-osteitis showed greater fluctuation in relation to the disease activity. The IL-2 production of five PPP patients with arthro-osteitis was greatly enhanced in the inactive stage compared with the active stage. Sera from two patients treated with a combination of etretinate and colchicine contained extremely low levels of IL-2 inhibitory activity. The increased IL-2 production in the inactive stage may be due in part to the depletion of IL-2 inhibitor-producing cells by the treatment.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005533:Foot Dermatoses / Q000276:immunology; D006229:Hand Dermatoses / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000276:immunology*
D007376:Interleukin-2; D008222:Lymphokines; C046147:interleukin 2 inhibitor