[Characteristics of hydrocortisone action on the biosynthesis of mitochondrial and cytoplasmic RNA in rat liver cells at different thyroid hormone levels in the body].
Hydrocortisone effect on RNA synthesis was shown to depend on thyroid hormone levels: the inducing action of hydrocortisone on RNA synthesis in liver mitochondria was revealed only in intact and triiodothyronine-treated thyroidectomized rats. In hypothyrosis hydrocortisone failed to produce a significant change in intensity of mitochondrial and cytoplasmic RNA synthesis.
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007037:Hypothyroidism / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000378:metabolism*; D013965:Thyroidectomy
D013963:Thyroid Hormones; D012313:RNA; D006854:Hydrocortisone
Osobennosti deĭstviia gidrokortizona na biosintez mitokhondrial'nykh i tsitoplazmaticheskikh RNK v kletkakh pecheni krys pri razlichnom urovne tireoidnykh gormonov v organizme.