Analysis of 309 cases after hydatidiform mole: different follow-up program according to biologic behavior.
Between 1976 and 1985, at the Obstetrics and Gynecology Department of Milan University, a total of 309 cases of hydatidiform mole, 223 complete moles and 86 partial moles, were monitored with the assay of beta-human chorionic gonadotropin, following a postmolar biochemical surveillance program. Spontaneous remission of the disease occurred in 287 (92.9%) patients. Marker levels were undetectable in 80.4% of cases within 60 days after evacuation of the mole and in 19.6% between 61 and 140 days. There were 22 (7.1%) patients diagnosed as having gestational trophoblastic tumors (GTT) and treated with chemotherapy: 20 were complete moles and 2 partial moles. Considering these data, the authors suggest different follow-up times for partial and complete moles and confirm the necessity of selection criteria in a diagnosis of GTT.
D002822:Choriocarcinoma / Q000209:etiology; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D012075:Remission, Spontaneous; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000209:etiology*; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments