title: Similarities between a predicted secondary structure for the M1 RNA ribozyme and the tRNA binding center of 16 S rRNA from E. coli.
abstract: We propose a new model for the secondary structure of the M1 RNA component of E. coli RNase P which is based on significant sequence homologies with parts of the E. coli 16 S rRNA. A large domain of the new model resembles closely the secondary structure of the tRNA binding center of 16 S rRNA. We suggest that this domain of M1 RNA when functioning as a ribozyme binds the mature part of the precursor tRNA.
mesh_terms: D001665:Binding Sites; D004722:Endoribonucleases; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial; D016337:RNA, Catalytic; D012335:RNA, Ribosomal / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D043262:Ribonuclease P; D012689:Sequence Homology, Nucleic Acid
chemical_list: D029968:Escherichia coli Proteins; D012329:RNA, Bacterial; D016337:RNA, Catalytic; D012335:RNA, Ribosomal; D012343:RNA, Transfer; D004722:Endoribonucleases; D043262:Ribonuclease P; C470865:ribonuclease P, E coli