The interaction of Cl- with a gramicidin-like channel.
Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10(-9)-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.
D006096:Gramicidin; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials; D008954:Models, Biological; D011188:Potassium
D007473:Ion Channels; D006096:Gramicidin; D011188:Potassium