Mechanism of the inhibitory effect of 11 beta-hydroxypregna-1, 4-diene-3, 20-dione (delta HOP) at high concentrations in RNA synthesis.
The strong inhibition of thymocyte-RNA synthesis by 11 beta-hydroxypregna-1, 4-diene-3, 20-dione (delta HOP) reported recently, fulfills the three conditions required for a non-genomic effect, i.e.: no persistence upon washing out, instantaneous action and effect in the presence of inhibitors of RNA synthesis. Injection of (delta HOP) into mice (2 mg/100 g) also causes a 32% inhibition in their thymocyte-RNA synthesis, but the mechanism of this latter inhibition has still not been clarified.
D000818:Animals; D003470:Culture Media; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism; D014529:Uridine / Q000378:metabolism*
D003470:Culture Media; D006908:Hydroxyprogesterones; C038404:pregna-1,4-diene-11-ol-3,20-dione; D012313:RNA; D014529:Uridine