Preservation of resuspended red cell concentrate. Red cell volume and hemolysis.
Sucrose in a concentration of 30 to 50 mmol/l preservation solution (10-20 mmol/l red cell concentrate (RCC) and 3-5 mmol per unit RCC) and an ionic strength of about 0.16 avoid changes of red cell volume during 6 weeks of storage. Increasing sucrose concentrations up to 80 mmol/l RCC decrease the hemolysis. But a sucrose concentration of only 10 mmol/l RCC causes an acceptable low hemolysis rate of 0.25% after 35 days of storage in PCV FENWAL plastic bags. Sucrose can be replaced by mannitol or sorbitol at the same final concentration. Changes in red cell metabolism and viability will not be expected.
D001793:Blood Preservation / Q000379:methods*; D017707:Erythrocyte Transfusion; D004911:Erythrocyte Volume / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D013395:Sucrose / Q000494:pharmacology
D013395:Sucrose