Anti-myelin-associated glycoprotein antibody in sera from patients with demyelinating diseases.
An enzyme-linked immunosorbent assay (ELISA) was developed for quantitating anti-myelin-associated glycoprotein (MAG) IgM antibody in human sera. Absorbance values of anti-MAG antibody were higher than 0.2 at 1:80 of serum dilution in sera from some patients with demyelinating diseases of the central or peripheral nervous systems including multiple sclerosis, subacute sclerosing panencephalitis, Guillain-Barré syndrome, chronic relapsing polyradiculoneuritis and carcinomatous polyneuropathy and also some patients with autoimmune diseases such as collagen diseases and myasthenia gravis. However, absorbance values of anti-MAG antibody in sera from control individuals and patients with some other neurological diseases were less than 0.2 and considered as negative. Because of the reported existence of a cross antigenicity between MAG and lymphocyte, and especially natural killer cells, the possibility of the functional importance of anti-MAG antibody on cellular immunity is discussed with particular reference to the demyelinating diseases.
D001323:Autoantibodies / Q000032:analysis*; D001528:Behcet Syndrome / Q000276:immunology; D002561:Cerebrovascular Disorders / Q000276:immunology; D003095:Collagen Diseases / Q000276:immunology; D003711:Demyelinating Diseases / Q000276:immunology*; D004660:Encephalitis / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D011129:Polyradiculoneuropathy / Q000276:immunology; D013132:Spinocerebellar Degenerations / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology
D001323:Autoantibodies; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein