title: [A case of a carcinoid of the duodenum (somatostatin-, serotonin- and ACTH-producing) with carcinoma of the stomach].
abstract: A case of a duodenal carcinoid which was producing somatostatin, serotonin and ACTH in a 65-year-old man is reported. The patient was found to have a submucosal protruded mass of the duodenal bulb and a tumor mass-like IIa + IIc in the antral portion of the stomach. Subtotal gastrectomy was performed and the histological diagnosis of the tumors were found to be a classical carcinoid of the duodenum and a well-differentiated tubular adenocarcinoma of the stomach. The carcinoid cells of the duodenum had numerous cyto-plasmic granules which were positive by Grimelius staining and negative by Hellerström-Hellmann staining, and 200-300 nm in size, electronmicroscopically. These cells were shown to contain somatostatin, serotonin or ACTH-positive cells by means of monoclonal immunohistochemistry, however, results were negative for gastrin, insulin, glucagon, calcitonin, VIP or PP.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000368:Aged; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology; D004379:Duodenal Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D012701:Serotonin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone