Identification of intermediate filament keratin proteins in parakeratinized odontogenic keratocysts. A preliminary study.
The keratin proteins were extracted from the epithelial lining of three odontogenic keratocyst specimens. Two of the specimens were from a patient with nevoid basal cell carcinoma syndrome; the third was a solitary lesion. Seven keratin proteins with molecular weights of 46, 48, 50, 52, 54, 58, and 59 kilodaltons were identified by SDS-polyacrylamide gel electrophoresis and immunoblotting with antikeratin antiserum. The reproducibility of the pattern of molecular markers implies a series of genetic events coincident with the characteristic pattern of epithelial differentiation.
D000328:Adult; D003101:Collodion; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008297:Male; D008336:Mandibular Diseases / Q000378:metabolism; D008439:Maxillary Diseases / Q000378:metabolism; D009807:Odontogenic Cysts / Q000032:analysis*
D007633:Keratins; D003101:Collodion