The effect of malathion on RNA polymerase activity of cell nuclei and transcription products in lymphocyte culture.
Malathion decreased polymerase activity of cell nuclei and inhibited RNA synthesis in cultured lymphocytes. The mechanism of action of this compound at the cellular level is suggested.
D002467:Cell Nucleus / Q000187:drug effects* / Q000201:enzymology; D002478:Cells, Cultured; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008294:Malathion / Q000633:toxicity*; D012313:RNA / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects*
D012313:RNA; D012321:DNA-Directed RNA Polymerases; D008294:Malathion