title: [Role of kinins in the pathogenesis of craniocerebral injury and the validation of corrective antiproteolytic therapy].
abstract: The role of the kinin system in the development of extra- and intracerebral complications in the acute period of severe craniocerebral trauma was studied from complex clinical and biochemical examination. The authors substantiate the expediency of applying corrective antiproteolytic therapy, in which case the predominant trend of its action--inhibition of kinin production in the vascular bed or on the tissue level--must be taken into account. The time, duration, and methods of Contrykal administration were developed.
mesh_terms: D000293:Adolescent; D000328:Adult; D007611:Aprotinin / Q000008:administration & dosage; D001930:Brain Injuries / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D004569:Electroencephalography; D006801:Humans; D007705:Kinins / Q000097:blood*; D008875:Middle Aged; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012887:Skull Fractures / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D013997:Time Factors
chemical_list: D007705:Kinins; D011480:Protease Inhibitors; D007611:Aprotinin
vernacular_title: Rol' kininov v patogeneze cherepno-mozgovoĭ travmy i obosnovanie korrigiruiushcheĭ antiproteoliticheskoĭ terapii.