[Comparative analysis of the specificity of poly- and monoclonal antiallotypic antibodies and allotype-recognizing T-lymphocytes in rats].
Using concurrent solid-phase radioimmunoassay, it has been shown that rat immunoglobulin k chain, Igk-lb allotype, is represented by a single serologically defined determinant. Anti-Igk-lb T cells do not recognize this determinant and poly- and monoclonal anti-Igk-lb antibodies show no influence on Igk-lb-specific proliferative T-cell response in vitro to IgG (Igk-lb)-pulsed splenic antigen-presenting cells. It is suggested that T cells recognize allotypic determinant(s) of processed Ig (Igk-lb) molecule.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000032:analysis / Q000276:immunology; D005260:Female; D007126:Immunoglobulin Allotypes / Q000032:analysis / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains; D014373:Tuberculin
Sravnitel'nyĭ analiz spetsifichnosti poli- i monoklonal'nykh antiallotipicheskikh antitel i allotipraspoznaiushchikh T-limfotsitov krys.