Merkel cell tumor coexpressing cytokeratin and neurofilament proteins.
Whorled filaments 10 nm in width were identified by anti-intermediate filaments antibodies in a Merkel cell tumor from a 52-year-old man. Immunohistochemical tests revealed that the tumor was stained with anti-keratin antibody and antibodies against the 68-kd and 200-kd subunits of neurofilament proteins but not antibody against the 150-kd subunit. This is the first reported case of Merkel cell tumor expressing a 200-kd subunit of neurofilament proteins.
D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016900:Neurofilament Proteins; D012878:Skin Neoplasms / Q000032:analysis* / Q000648:ultrastructure
D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D007633:Keratins