Ryanodine does not affect the potassium channel from the sarcoplasmic reticulum of skeletal muscle.
Single K channels from skeletal muscle sarcoplasmic reticulum were incorporated into artificial membranes. Ryanodine applied to either side of the membrane did not affect the gating nor the conductance properties of those channels. These results suggest that the site of action of ryanodine is limited only to the calcium channels present in the membrane of sarcoplasmic reticulum (1).
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D008051:Lipid Bilayers; D009132:Muscles / Q000648:ultrastructure; D011188:Potassium / Q000502:physiology*; D012433:Ryanodine / Q000494:pharmacology*; D012519:Sarcoplasmic Reticulum / Q000187:drug effects*
D000470:Alkaloids; D007473:Ion Channels; D008051:Lipid Bilayers; D012433:Ryanodine; D011188:Potassium; D002118:Calcium