Histamine release from basophil leukocytes in asthma patients after in vitro provocation with various neuromuscular blocking drugs and intravenous anaesthetic agents.
Basophil histamine release is a relatively new investigation technique, which can be used in the diagnosis of anaphylactoid reactions. Our aim in this investigation was to determine reference values for asthma patients and normal subjects. Blood from eight asthmatic patients and eight normal subjects was tested for histamine release after in vitro provocation with various neuromuscular blocking drugs and intravenous anaesthetic agents. There was significantly higher histamine release for asthmatic patients than for normal subjects, P less than 0.001 (analysis of variance). This had no effect on the calculated reference value (mean +/- 2 s.d.), which was found to be 0-30%.
D000777:Anesthetics / Q000494:pharmacology*; D001249:Asthma / Q000276:immunology*; D001491:Basophils / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D012016:Reference Values
D000777:Anesthetics; D009466:Neuromuscular Blocking Agents