Oxygen radical formation during redox cycling of bleomycin-Fe(III) catalyzed by NADPH-cytochrome P-450 reductase of liver microsomes and nuclei.
D000818:Animals; D001761:Bleomycin / Q000378:metabolism* / Q000494:pharmacology / Q000031:analogs & derivatives; D002467:Cell Nucleus / Q000201:enzymology*; D002712:Chlorides; D005290:Ferric Compounds / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D002712:Chlorides; D005290:Ferric Compounds; C023503:iron bleomycin; D001761:Bleomycin; D009251:NADPH-Ferrihemoprotein Reductase; C024555:ferric chloride