title: Tissue specific methylation of c-myc in adult chickens.
abstract: Methylation of cytosine in DNA has long been correlated with modulation of specific gene expression in eukaryotes. Methylation of the c-myc locus was examined in six tissues from adult Leghorn chickens. The c-myc locus was found to be variably methylated in all examined tissues, except blood, where erythrocytic DNA showed no evidence of significant methylation of c-myc. This is contrasted with the observed sever methylation of the beta actin locus and the generally high methylation patterns found in avian erythrocytic DNA.
mesh_terms: D000199:Actins / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D002645:Chickens / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000378:metabolism*; D004262:DNA Restriction Enzymes; D019003:Deoxyribonuclease HpaII; D004912:Erythrocytes / Q000378:metabolism; D005895:Gizzard, Avian / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008745:Methylation; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009857:Oncogenes
chemical_list: D000199:Actins; D004247:DNA; D004262:DNA Restriction Enzymes; D019003:Deoxyribonuclease HpaII