Visual evoked potentials in patients with neuropathy and macroglobulinemia.
Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
D000368:Aged; D001798:Blood Proteins / Q000134:cerebrospinal fluid* / Q000276:immunology; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000134:cerebrospinal fluid / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology / Q000503:physiopathology*; D008258:Waldenstrom Macroglobulinemia / Q000134:cerebrospinal fluid / Q000276:immunology / Q000503:physiopathology*
D001798:Blood Proteins; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein