Demonstration of perivascular peptides and changes in concentration with age in man.
By immunocytochemistry, human cerebral arteries have been found to be invested by perivascular fibres which contain neuropeptide Y, substance P and vasoactive intestinal polypeptide (VIP). The concentrations of the peptides are comparable for substance P and VIP, whereas that of neuropeptide Y is much higher. A marked reduction in radioimmunoassayable peptide levels was observed with advancing age of the patients.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002536:Cerebral Arteries / Q000032:analysis / Q000294:innervation*; D002648:Child; D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y; D011863:Radioimmunoassay; D013373:Substance P / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide