Implications of a mathematical model for the role of lymphocytes with different lifespans in the recovery from tolerance.
An extension of the mathematical model of immunological tolerance including two categories of B and T helper cells, each having a different lifespan, is presented. The simulated recovery from tolerance is compared with experimental data on B and T helper cell tolerance to human gamma globulin (HGG) induced in adult mice. The performed simulation runs suggest the conclusion that in this case it seems impossible to incorporate a high ratio of both, long-lived B cells and/or short-lived T helper cells, if good agreement with the available experimental data should be preserved.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology
D005719:gamma-Globulins