[The role of edema in cerebral ischemia. From physiopathology to therapeutics].
Brain ischemia induces an original form of edema associating a "cytotoxic" component and a "vasogenic" component which is more inconstant. The authors set out a synthesis of fundamental research concerning the different factors of ischemic brain edema. Although anti-edematous drugs (steroids, barbiturates, diuretics) are widely used, there is no serious evidence of their efficacity. New therapies are based on a specific approach of the different disturbances of cerebral ischemia. However, controlled studies are necessary to evaluate the effects of these new drugs.
D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy*; D002545:Brain Ischemia / Q000150:complications*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006801:Humans
Place de l'oedème dans l'ischémie cérébrale. De la physiopathologie à la thérapeutique.