[DNA, RNA and protein synthesis in hepatitis A virus-infected cells].
Synthesis of DNA, RNA, and protein macromolecules was observed in cells infected with a strain of HA virus which had undergone 11 passages in the same culture. At 24-hour intervals the infected and uninfected cells were pulse-labeled with 1 microCi/cc 3H-thymidine, 3H-uridine, and 14C-valine. In 6-9 days after cell inoculation, inhibition of DNA, RNA, and protein synthesis was observed, being most marked in DNA synthesis. The synthesis of these macromolecules increases on the 10-13th day which coincides with virus antigen accumulation in the cell cytoplasm.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D006506:Hepatitis A / Q000276:immunology / Q000378:metabolism*; D006507:Hepatovirus / Q000276:immunology; D046911:Macromolecular Substances; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D013997:Time Factors; D014776:Virus Cultivation
D000956:Antigens, Viral; D046911:Macromolecular Substances; D012313:RNA; D004247:DNA
Sintez DNK, RNK i belkov v kletkakh, zarazhennykh virusom gepatita A.