title: Spontaneous and experimental myofibrillar hypoplasia and its relation to splayleg in newborn pigs.
abstract: The relation of myofibrillar hypoplasia to clinical splayleg was studied. A strain of Belgian Landrace sows was selected for this study because they produced pigs which had no myofibrillar hypoplasia. Myofibrillar hypoplasia could nevertheless by induced experimentally in these animals by dexamethasone treatment of the sows during late pregnancy. The lesion was observed without clinical signs and was compared to the myofibrillar hypoplasia in clinical cases of splayleg. The differences between these 2 groups may account for the appearance of clinical signs. These differences included the maturity of the myofibrils and the degree of autophagolysosomal glycogen breakdown.
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006651:Histocytochemistry; D008854:Microscopy, Electron; D009135:Muscular Diseases / Q000139:chemically induced / Q000151:congenital / Q000473:pathology / Q000662:veterinary*; D009210:Myofibrils / Q000473:pathology* / Q000648:ultrastructure; D011247:Pregnancy; D012313:RNA / Q000032:analysis; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000473:pathology*
chemical_list: D012313:RNA; D003907:Dexamethasone; D004247:DNA