Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo.
The in vivo blood pressure lowering effect of three vasodilators whose in vitro effects are endothelium-dependent (acetylcholine, substance P and adenosine triphosphate) was reduced by 40-60% after systemic treatment of the animals with gossypol. In vitro, gossypol is an inhibitor of the production and/or release of endothelium-derived relaxing factor. Systemically administered gossypol had no effect on blood pressure decreases produced by the endothelium-independent agents prostaglandin E1 (alprostadil) and glyceryl trinitrate. These results suggest that endothelium-mediated vasodilator mechanisms could participate in blood pressure regulation.
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology; D001688:Biological Products / Q000037:antagonists & inhibitors*; D001794:Blood Pressure / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006072:Gossypol / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide; D005996:Nitroglycerin / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors*
D001688:Biological Products; D011458:Prostaglandins E; D014665:Vasodilator Agents; D009569:Nitric Oxide; D013373:Substance P; D000255:Adenosine Triphosphate; D005996:Nitroglycerin; D006072:Gossypol; D000109:Acetylcholine