The significance of plasma CCK and secretin in the oleate-stimulated pancreatico-biliary secretion in man.
In eight normal persons the plasma levels of secretin and cholecystokinin (CCK) measured after intraduodenal oleate were reproduced by intravenous (i.v.) infusion of synthetic secretin (3.4 pmol.kg-1.h-1) and CCK-8 (17.5 pmol.kg-1.h-1), either alone or in combination. Using an indicator dilution technique, the combined infusions of the two hormones were found to account for all the pancreatico-biliary secretion of amylase, bicarbonate, bile salts and volume elicited in response to intraduodenal oleate, pH 6. Furthermore, the bicarbonate secretion and the flow rate elicited by secretin were augmented by CCK, whereas no augmentation was found with regard to the CCK-stimulated enzyme and bile salts output.
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001659:Biliary Tract / Q000187:drug effects / Q000378:metabolism*; D002766:Cholecystokinin / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011897:Random Allocation; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
D001639:Bicarbonates; D001647:Bile Acids and Salts; D009829:Oleic Acids; D012633:Secretin; D019301:Oleic Acid; D002766:Cholecystokinin; D000681:Amylases