Argyrophilic, 'carcinoid-like' prostatic carcinoma. An immunocytochemical study.
Four cases of argyrophilic or carcinoid-like prostatic carcinoma were studied immunocytochemically, using immunoperoxidase stains for prostatic-specific antigen, neuron-specific enolase, hydroxytryptamine (serotonin), somatostatin, and adrenocorticotropic hormone. All four showed strong positive reaction to prostatic-specific antigen and uniformly negative results with neuron-specific enolase, hydroxytryptamine, somatostatin, and adrenocorticotropic hormone. These findings lend further support to the concept that this particular prostatic tumor is truly a carcinoma that somehow manifests a carcinoid-like histomorphology, but does not possess evidence of true neuroendocrine or carcinoidal nature.
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001129:Argyria / Q000473:pathology*; D001344:Autopsy; D002276:Carcinoid Tumor / Q000473:pathology*; D003937:Diagnosis, Differential; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D013194:Staining and Labeling