The structure-function relationships in the ionic channels of the axonal membranes as revealed by deuteration.
The present study has two purposes: c) to summarize our most important experimental results concerning the deuteration effects on the Ranvier node membrane as well as those obtained by others on the giant axons; ii) to reveal the significance of the macroscopic-microscopic correlations reflected in the excitation processes which underlie the ionic channel behaviour and for which deuteration has provided a new alternative of investigating the molecular mechanisms.
D000818:Animals; D001369:Axons / Q000378:metabolism; D003903:Deuterium / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D011901:Ranvier's Nodes / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium; D003903:Deuterium; D011188:Potassium