[Evaluation of the effect of cardiotropic agents using a mathematical model of electromechanical coupling].
An assessment of the ionic action mechanism of cardiotropic substances with the aid of a mathematical model for excitation-contraction coupling in myocardium is proved to be possible. The technique developed consists in the model parameter identification from the experimental data on electrical and mechanical activity of myocardial strip. The validity of the technique is tested using the known mechanism drugs. An example is given of analysis by the technique suggested of the action mechanism of diltiazem on the rat papillary muscle.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003198:Computer Simulation; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008433:Mathematics; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D051381:Rats
D002316:Cardiotonic Agents; D007473:Ion Channels; D002118:Calcium
Otsenka deĭstviia kardiotropnykh veshchestv s pomoshch'iu matematicheskoĭ modeli élektromekhanicheskogo sopriazheniia.