[Avirulent mutants of the rabies virus: change in site III of the glycoprotein].
Using antiglycoprotein neutralizing monoclonal antibodies, avirulent mutants of rabies virus have been selected. All these mutants have a change in the site III of the glycoprotein: Arginine 333 is replaced by either glutamine, or isoleucine, or glycine. The possibility of selecting avirulent mutants by using neutralizing monoclonal antibodies may allow to get live vaccines and to study the molecular basis of viral virulence.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D000939:Epitopes; D006023:Glycoproteins / Q000235:genetics* / Q000276:immunology; D051379:Mice; D009154:Mutation; D011820:Rabies virus / Q000235:genetics / Q000472:pathogenicity*; D051381:Rats; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology; D014774:Virulence
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D006023:Glycoproteins; D014764:Viral Proteins
Mutants avirulents du virus rabique: altération du site III de la glycoprotéine.