title: Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion.
abstract: Of the several types of treatment for cystic hygromas and lymphangiomas, surgical excision has been the preferred treatment. However, there is a high recurrence rate because lymphangiomas tend to infiltrate the surrounding tissues. Bleomycin in a microsphere-in-oil (S/O) emulsion was used in this study as a sclerosing agent for lymphangiomas. Experimental studies using domestic rabbits showed that the bleomycin emulsion caused more marked fibrotic changes at the injection site than other formulations, such as a blank emulsion and bleomycin solution. In clinical trials, 27 of 33 patients received bleomycin S/O emulsion injected directly into the tumors with satisfactory results. Histologic pictures of the clinically resected specimens confirmed the findings of the experimental studies. Comparative studies of treatments between bleomycin S/O emulsion and surgery indicated that injection therapy of bleomycin S/O emulsion would be more beneficial than surgical excisions.
mesh_terms: D000818:Animals; D001365:Axilla; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D004655:Emulsions / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008202:Lymphangioma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D009333:Neck; D011817:Rabbits
chemical_list: D004655:Emulsions; D001761:Bleomycin