Airway hyper-reactivity and blood, lung and airway eosinophilia in rats treated with Sephadex particles.
The intravenous injection of Sephadex particles (G200) into rats produced a specific increase in numbers of blood eosinophils peaking 7 days later. A second injection, given on day 14 when the numbers of blood eosinophils had fallen to control levels, produced a dose-dependent increase in numbers, greater than the first, and peaking 5 days later. At this time there was a dose-dependent increase in numbers of eosinophils, but not of other leucocytes, in broncho-alveolar lavage fluids and lung tissue, together with an increase in sensitivity of the rats to the respiratory effect produced by the intravenous injection of 5-hydroxytryptamine.
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage*; D004802:Eosinophilia / Q000209:etiology*; D007156:Immunologic Memory; D007275:Injections, Intravenous; D008168:Lung / Q000276:immunology*; D008297:Male; D012123:Pulmonary Ventilation / Q000187:drug effects; D051381:Rats; D012137:Respiratory System / Q000276:immunology*; D012701:Serotonin / Q000494:pharmacology; D014235:Trichinellosis / Q000276:immunology
D003911:Dextrans; D012701:Serotonin; C025614:sephadex