title: [Comparative evaluation of the effectiveness of radiotherapy and chemo-radiotherapy of stage III-IV nasopharyngeal cancer].
abstract: The paper is concerned with the results of radiation and chemoradiotherapy of stage III-IV rhinopharyngeal cancer. Short- and long-term therapeutic results, the time of a recurrence-free course, the frequency of recurrences and metastasizing, expression of reactions, and complications were used as criteria. The most effective method of combined therapy of locally spread rhinopharyngeal cancer was polychemotherapy (bleomycetin, methotrexate, vinblastine, and cyclophosphamide) before irradiation with subsequent maintenance cyclophosphamide chemotherapy once in 4 weeks for 3-6 months. The 5-year survival rate for combined modality therapy of stage III-IV rhinopharyngeal cancer was within 62%, for radiotherapy used alone-50%.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011379:Prognosis; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003520:Cyclophosphamide; D008727:Methotrexate
vernacular_title: Sravnitel'naia otsenka effektivnosti luchevogo i khimioluchevogo lechenia raka nosoglotki III-IV stadiĭ.