Intranigral injection of dynorphin in combination with substance P on striatal dopamine metabolism in the rat.
The effects of intranigral injection of dynorphin(1-13), substance P and their combination on striatal dopamine (DA) metabolism as well as circling behavior were studied in rats. Dynorphin(1-13) produced a significant dose-dependent increase of dihydroxyphenyl acetic acid (DOPAC) concentration as well as the number of contralateral circling. No change in dopamine (DA) concentration was observed. Substance P caused a dose-dependent increase of DOPAC concentration. At large doses it also produced an increase in DA concentration. Combined intranigral dynorphin(1-13) and substance P brought about an additive effect for the increase of DOPAC and the number of contralateral circling. No additive effect was found when dynorphin(1-13) and neurokinin A were injected together intranigrally.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D004399:Dynorphins / Q000494:pharmacology*; D007839:Functional Laterality; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D013373:Substance P; D009270:Naloxone; D004399:Dynorphins; D004298:Dopamine