Serial measurement of arterial and internal jugular venous creatine kinase isoenzyme BB (CK-BB) after deep hypothermic total circulatory arrest in pediatric cardiac surgery.
Profound hypothermia and circulatory arrest in infants and children undergoing cardiac surgery were followed by abnormally high plasma levels of creatine kinase isoenzyme BB (CK-BB). Differences in the levels of enzymes in the femoral arterial and jugular venous blood indicated that the origin of the additional enzyme was the brain. The extent of the rise in enzyme levels was related to the duration of circulatory arrest. These data suggest that measurements of the CK-BB enzyme in plasma provide quantitative information about cerebral damage during cardiac surgery.
D001921:Brain / Q000201:enzymology; D002315:Cardiopulmonary Bypass; D003402:Creatine Kinase / Q000097:blood*; D005263:Femoral Artery; D006324:Heart Arrest, Induced / Q000009:adverse effects; D006330:Heart Defects, Congenital / Q000201:enzymology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007432:Intraoperative Period; D007527:Isoenzymes; D007601:Jugular Veins
D007527:Isoenzymes; D003402:Creatine Kinase