[Morphological characteristics of the sequelae from the parenteral administration of solutions of hydroxyethyl starch].
Rats and rabbits were infused with solutions of hydroxyethyl starch (HES) with different physical and chemical properties. Large quantities of HES produced specific macrophage reaction in the spleen. When used in therapeutic doses (plasmaexpander) HES caused no macrophage reaction. HES proved to be non-toxic for the internal organs.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004305:Dose-Response Relationship, Drug; D006895:Hydroxyethyl Starch Derivatives / Q000633:toxicity*; D007263:Infusions, Parenteral; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D051381:Rats; D012996:Solutions; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013213:Starch / Q000031:analogs & derivatives*; D013997:Time Factors
D006895:Hydroxyethyl Starch Derivatives; D012996:Solutions; D013213:Starch
Morfologicheskaia kharakteristika posledstviĭ parenteral'nogo vvedeniia rastvonov oksiétilirovannogo krakhmala.