What is a T-cell clone? Effect of rIFN on T-cell clone function and T-cell receptor gene rearrangement.
A T4+ proliferative, noncytotoxic cloned line acquires specific lytic function by treatment with recombinant interferon alpha or gamma. Simultaneous with the acquisition of this new cell function, a rearrangement of the T-cell receptor alpha gene occurs. These changes necessitate a revised concept of a T-cell clone regarding its T-cell receptor gene configuration and cell function.
D002460:Cell Line; D002999:Clone Cells / Q000502:physiology; D003101:Collodion; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000235:genetics; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000187:drug effects / Q000235:genetics*; D011994:Recombinant Proteins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology
D000939:Epitopes; D007369:Interferon Inducers; D011948:Receptors, Antigen, T-Cell; D011994:Recombinant Proteins; D003101:Collodion; D007372:Interferons