Immunological similarities between an experimental autoimmune myasthenia gravis model and human myasthenia gravis.
The induction of experimental autoimmune myasthenia gravis (EAMG) in rabbits after immunization with an acetylcholine (ACh) conjugate was found to possess immunological similarities with human myasthenia gravis. Anti-ACh antibodies, present in human sera, recognized the antigenic determinant, glutarylcholine, used to raise anti-ACh antibodies in rabbits. Identification of anti-anti-ACh antibodies in MG patients enabled us to test for recognition of the anti-ACh antibodies present in rabbit sera. The reverse, the recognition of rabbit auto-anti-anti-ACh antibodies by human anti-ACh antibodies was also tested and found to be specific.
D000109:Acetylcholine / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies; D004195:Disease Models, Animal; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000276:immunology
D001323:Autoantibodies; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D011950:Receptors, Cholinergic; D000109:Acetylcholine