title: Partial hepatectomy decreases pancreatic parenchymal enzyme activity.
abstract: In previous studies of liver regeneration following partial hepatectomy (PH) in rats, we noted a decrease in serum amylase activity. The present study was carried out to determine if the decrease in serum amylase following PH corresponds to a decrease in pancreatic parenchymal exocrine enzyme activity. Male Wistar rats (275 g) underwent either 60% PH or sham laparotomy (SL). A third group, serving as controls (CON), received no surgical procedure. All groups were pair-fed a nutritionally balanced diet. After 48 hr, pancreas, blood, and liver were removed for analysis. Results showed that PH decreased pancreatic parenchymal protein by 43%, lipase by 44%, and trypsin by 22% compared to controls. Serum amylase decreased by 28%, a finding similar to previous experiments. However, pancreatic parenchymal amylase activity was not affected. It remains to be determined whether the reduced pancreatic function affects digestion and absorption.
mesh_terms: D000681:Amylases / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001774:Blood Chemical Analysis; D006498:Hepatectomy / Q000379:methods*; D008099:Liver / Q000033:anatomy & histology; D008115:Liver Regeneration; D009929:Organ Size; D010179:Pancreas / Q000033:anatomy & histology / Q000201:enzymology* / Q000378:metabolism
chemical_list: D000681:Amylases