Adherence of cells to myelin basic protein. I. Adherence of red and white blood cells from patients with multiple sclerosis to myelin basic protein.
Red blood cells (RBC) and white blood cells (WBC) of patients with multiple sclerosis (MS) show decreased adherence to myelin basic protein (MBP) immobilized on plastic surfaces compared to the binding of cells from patients with other neurological diseases (OND), or such other autoimmune diseases as psoriasis (PS), and to that of healthy controls (HC). No similar phenomenon occurred to basic and non-basic type proteins other than MBP, for example, to histone (HIS), lysozyme (LYS) and ovalbumin (OVA). Thus, decreased adherence of RBC and WBC in MS patients to MBP appears to be a unique feature of the disease if compared with OND or PS.
D002448:Cell Adhesion; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000502:physiology*; D009103:Multiple Sclerosis / Q000097:blood*; D004676:Myelin Basic Protein; D012016:Reference Values; D013329:Structure-Activity Relationship
D004676:Myelin Basic Protein