Presence of I-region gene products on the cells and their products of the dengue virus-induced suppressor pathway.
We have studied both the cells and the suppressor factors of the dengue virus-induced suppressor pathway for the presence of I-region gene products. The suppressor activity of Ts1, Ts2 and Ts3 cells was abrogated by treatment with anti I-Jk or I-Ak anti-sera and complement. Both the suppressor factors were absorbed out by anti I-Jk and I-Ak immunosorbent columns. The activity of the suppressor factor was abolished by treatment with anti I-Jk antisera. Macrophage presentation of suppressor factor to precursors of Ts2 cells was abolished by treatment with anti I-Ak antisera and complement but not by anti I-Jk antisera. Thus I-region gene products were found throughout the dengue virus induced suppressor pathway.
D000818:Animals; D003165:Complement System Proteins / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D000939:Epitopes / Q000235:genetics*; D005802:Genes, MHC Class II; D006649:Histocompatibility Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C043911:I-J-antigen; D013491:Suppressor Factors, Immunologic; D003165:Complement System Proteins