title: Homozygous sickle cell disease and priapism in the eastern province of Saudi Arabia.
abstract: Two adult sickle cell homozygotes from the eastern oases of the Kingdom of Saudi Arabia presented with severe persistent priapism. Each patient had a high Hb F of 24%, and their red cells were neither hypochromic nor microcytic. Priapism probably occurs more frequently in homozygous sickle cell disease than reported previously from this region. It would appear that a high fetal haemoglobin alone without hypochromia and microcytosis--features suggestive of co-existing alpha-thalassaemia--does not protect against this agonizing vaso-occlusive event.
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000209:etiology*; D005319:Fetal Hemoglobin / Q000032:analysis; D006720:Homozygote; D006801:Humans; D008297:Male; D011317:Priapism / Q000097:blood / Q000150:complications*; D012529:Saudi Arabia; D012805:Sickle Cell Trait / Q000097:blood / Q000209:etiology* / Q000235:genetics
chemical_list: D005319:Fetal Hemoglobin