[Comparative study of the effectiveness of ethacizine, etmozin and Ritmilen in patients with ventricular rhythmic disorders].
Antiarrhythmic effect of ethacizine, a new Soviet compound, was compared to those of etmozin and Ritmilen. Ethacizine was given to 30 patients with chronic ventricular rhythm disorders, including those with frequent extrasystoles, bigeminy, paired extrasystoles and runs of ventricular tachycardia. Coronary patients prevailed in the sample. Holter's ECG monitoring was used for the assessment of treatment efficiency. Ethacizine showed the best anti-arrhythmic effect (81%), suppressing frequent extrasystoles as well as high-grade extrasystoles in the highest proportion of cases. The lowest efficiency (38%) in combination with the highest incidence of side effects were associated with Ritmilen, while etmozin kept somewhat in between (58% response rate).
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004206:Disopyramide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D016293:Moricizine; D010640:Phenothiazines / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D016293:Moricizine; C046818:ethacizine; D004206:Disopyramide
Sravnitel'noe izuchenie éffektivnosti étatsizina, étmozina i ritmilena u bol'nykh s zheludochkovymi narusheniiami ritma serdtsa.