title: The impact of screening for open neural tube defects in England and Wales.
abstract: Using information derived from the voluntary system of notification of congenital malformations in England and Wales, the birth prevalence of anencephaly and spina bifida was estimated to have declined by 80 per cent from 31.5 to 6.2 per 10,000 between 1964-1972 and 1985. Over the same period, notified terminations of pregnancy with a suspected fetal central nervous system abnormality increased from less than 1 per cent to 56 per cent of neural tube defect births and central nervous system terminations combined, accounting for 31 per cent of the decline in births. Routinely collected national statistics provide a method for monitoring the impact of screening for open neural tube defects. However because they are incomplete and lack detail an alternative method of monitoring is needed. This paper includes an outline of such a method, together with the results of a pilot study designed to assess the feasibility of monitoring screening in the Oxford Region.
mesh_terms: D000649:Amniocentesis; D000757:Anencephaly / Q000453:epidemiology*; D004739:England; D005260:Female; D006554:Hernia, Umbilical / Q000453:epidemiology; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009436:Neural Tube Defects / Q000453:epidemiology*; D011247:Pregnancy; D016136:Spina Bifida Occulta / Q000453:epidemiology*; D014852:Wales; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins