[Effects of dihydrostreptomycin and gentamycin on platelet membrane Na+-K+ATPase].
The use of aminoglycosides is characterised by a bound linkage between therapeutic and toxical levels. The aim of our study was to define the influence of diidrostreptomicin and gentamicin over Na+-K+ATPase of membranes of platelets. In this study, Bounting's and Caravaggio's method has been used, while ATPase activity was expressed in n mol of hydrolized ATP/min/mg of proteins. The data so obtained showed that the antibiotics were able to block up ATPase activity.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D005839:Gentamicins; D000254:Sodium-Potassium-Exchanging ATPase; D004096:Dihydrostreptomycin Sulfate
Azione della diidrostreptomicina e della gentamicina sulla Na+-K+ATPasi di membrana piastrinica.