Molecular forms of somatostatin, substance P and neurotensin in fresh human cerebral cortex.
The molecular forms of somatostatin, substance P and neurotensin in fresh normal human cerebral cortex have been investigated using high performance liquid chromatography and radioimmunoassay. For each peptide most of the immunoreactivity measured corresponds to a single molecular form co-eluting with the authentic peptide. Small differences in the minor peaks of somatostatin and substance P immunoreactivity are seen when compared to the results of similar studies on post mortem human brain. A substantial difference in the molecular forms of neurotensin was seen which suggests that degradation of this peptide may occur post mortem.
D000328:Adult; D002540:Cerebral Cortex / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D009496:Neurotensin / Q000032:analysis*; D011863:Radioimmunoassay / Q000379:methods; D013004:Somatostatin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
D013373:Substance P; D009496:Neurotensin; D013004:Somatostatin