[Synthesis of lipid A analogs. Preparation of serologically active glycolipids on the basis of beta-1,4-glucosaminobiose (chitobiose)].
Synthesis of beta-1,4-glucosaminobiose (chitobiose) 4'-phosphates N,N'-diacylated with (R)-3-hydroxymyristic acid is described, the structure being corroborated by 13C-NMR spectra. It was shown that activity of the components in various reactions with antibodies to lipid A from Yersinia pseudotuberculosis is similar to the lipid A activity.
D055598:Chemical Phenomena; D002621:Chemistry; D004187:Disaccharides; D000939:Epitopes / Q000032:analysis*; D005936:Glucans; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000276:immunology
D004187:Disaccharides; D000939:Epitopes; D005936:Glucans; D008050:Lipid A; C032438:chitobiose
Sintez analogov lipida A. Poluchenie serologicheski aktivnykh glikolipidov na osnove beta-1,4-gliukozaminobiozy (khitobiozy).