Immunohistochemical study of the appearance of some markers in liver adjoining hepatocellular carcinoma.
The presence and distribution of AFP, AAT and HBsAg in peritumoral non-neoplastic hepatocytes (NNH) of 27 cases and, at the same time, in the neoplastic tissue of 37 liver cell carcinoma (HCC) were studied; AFP and HBsAg were more frequently found in NNH than in HCC cells; no differences were found for AAT. The presence of HBsAg also in normal liver without cirrhosis is probably best explained by its possible role in neoplastic transformation and by the inhibition of replication of the viruses AFP, considered to be expression of dedifferentiated cells, may possible be taken up by NNH for catabolic purposes.
D000368:Aged; D000941:Antigens / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000032:analysis* / Q000473:pathology; D003594:Cytoplasmic Granules / Q000032:analysis / Q000473:pathology; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000032:analysis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D000941:Antigens; D006514:Hepatitis B Surface Antigens; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins