[Effect of the neurotoxin apamin on ion currents in membranes of heart fibers].
It has been shown on auricle fibres of the frog that neurotoxin apamin in extremely low concentrations (10(-10)-10(-9) M) suppresses the current entering in the cell through calcium channels of the membrane, but it increases tonic contraction related to Na/Ca exchange. No significant effects on fast sodium and potassium channels were observed. The results show that the mechanism of apamin effect on the heart is to a large extent conditioned by specific influence on Ca transport through the cell membranes.
D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011895:Rana ridibunda
D001514:Bee Venoms; D007473:Ion Channels; D001030:Apamin; D011188:Potassium
Vliianie neĭrotoksina apamina na ionnye toki membran serdechnykh volokon.