The ability of des-Arg9-bradykinin to relax rabbit isolated mesenteric arteries is acquired during in vitro incubation.
Strips of rabbit mesenteric arteries precontracted with phenylephrine relaxed when exposed to des-Arg9-bradykinin (BK), a typical B1 receptor agonist. We showed that the ability of des-Arg9-BK to relax this preparation was acquired during in vitro incubation and was abolished by cycloheximide treatment. In this preparation intimal damage reduced but did not abolish the relaxant effect of des-Arg9-BK, and indomethacin uncovered a contractile effect of des-Arg9-BK also acquired during the in vitro incubation.
D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology
C024626:bradykinin, des-Arg(9)-; D010656:Phenylephrine; D013373:Substance P; D003513:Cycloheximide; D001920:Bradykinin