title: [Features of indoleamine metabolism in adolescent girls with delayed sexual development].
abstract: Indolamine metabolism was studied in 203 patients with retarded sexual development of different genesis and in 116 girls of the same age. Considerable disorders in the level of serotonin and the products of its metabolism: 5-oxy-indoleacetic acid and melatonin, a hormone synthesized by the pineal gland--were found in abnormal sexual maturation. The nature of revealed changes depended, to a large extent, on genesis of disease which could be used for differential diagnosis of different forms of retarded sexual development. Possible involvement of indolamines in pathogenetic mechanisms ensuring the formation of a pathological process, was discussed.
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000097:blood; D003937:Diagnosis, Differential; D004700:Endocrine System Diseases / Q000097:blood*; D005260:Female; D006059:Gonadal Dysgenesis / Q000097:blood; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D008550:Melatonin / Q000097:blood*; D008599:Menstruation Disturbances / Q000097:blood; D010049:Ovarian Diseases / Q000097:blood; D012701:Serotonin / Q000097:blood*; D012741:Sexual Maturation; D014424:Turner Syndrome / Q000097:blood
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin
vernacular_title: Osobennosti obmena indolaminov u devochek-podrostkov s zaderzhkoĭ polovogo razvitiia.