[Pharmacologic study of nicergoline in the pathology of the cervico-prostatic sphincter].
An urodynamic survey and an E.M.G. of the striated sphincters were performed in 20 patients presenting with prostatism, before and after infusion of either nicergoline or placebo, under double-blind conditions. Statistical analysis was performed and demonstrated a significant decrease in the tone of the bladder neck, the prostate, the striated sphincter and the bladder; impoverished electromyographic activity of the striated sphincters; increased maximal and mean urine flow and decreased post-voiding residue. The authors stress the efficacy of nicergoline in cervico-prostato-sphincteric syndromes.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004576:Electromyography; D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009530:Nicergoline / Q000494:pharmacology*; D010919:Placebos; D011467:Prostate / Q000187:drug effects; D011470:Prostatic Hyperplasia / Q000503:physiopathology*; D001743:Urinary Bladder / Q000187:drug effects; D001748:Urinary Bladder Neck Obstruction / Q000175:diagnosis* / Q000209:etiology
D004873:Ergolines; D010919:Placebos; D009530:Nicergoline
Etude pharmacologique de la nicergoline dans la pathologie cervico-prostatique.