[Microiontophoretic study of the chemical sensitivity of neurons in the medial hypothalamus to substance P in rats].
Chemical sensitivity of the medial hypothalamic neurons to microiontophoretically applied substance P was studied in male immobilized Wistar rats. Over half of the neurons responding to the substance P by either increase or decrease of their firing rate. Neurons were found that changed their responses under repeated application of the peptide. The immobilization stress in rats seems to induce changes in chemical sensitivity of the medial hypothalamus neurons to substance P.
D000200:Action Potentials; D000818:Animals; D007033:Hypothalamus, Middle / Q000502:physiology*; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology; D013373:Substance P / Q000008:administration & dosage / Q000502:physiology*
D013373:Substance P
Mikroionoforeticheskoe issledovanie khimicheskoĭ chuvstvitel'nosti neĭronov medial'nogo gipotalamusa k substantsii P u krys.