[Effectiveness of the antitumor action of bleomycetin in short-term hyperglycemia].
Experimental studies on rats with sarcoma 45 showed that antitumor efficacy of bleomycetin could be markedly increased by inducing short-term hyperglycemia. It was noted that the theoretical value of the additive effect of these factors was lower than the experimental one. This is in favour of the synergistic mechanism of bleomycetin action under conditions of hyperglycemia.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use* / Q000031:analogs & derivatives; D004353:Drug Evaluation, Preclinical; D006943:Hyperglycemia / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C025703:bleomycetin
Effektivnost' protivoopukholevogo deĭstviia bleomitsetina v usloviiakh kratkovremennoĭ giperglikemii.