title: The effect of focal interictal spikes on perception and reaction time. II. Neuroanatomic specificity.
abstract: By means of a computerized system of spike detection, presentation of visual stimuli, and timing of a button press, we showed previously that single posterior interictal spikes resulted in transient prolongation of reaction time and increased non-response rate in 3 subjects. By varying the response hand and the visual field of stimulus, conditions with maximum spike effect were defined more precisely, in relationship to the location of the spike. In general, spike-induced dysfunction was most pronounced when either response hand or visual field of stimulus was contralateral to the spike. This not only was true across all 3 subjects, but held even for independent right and left occipital spikes within the same subject. Also, perceptual versus motor aspects were differentially affected by the anterior-posterior location of the spike. These findings indicate that focal interictal spikes may transiently disrupt aspects of cortical functioning corresponding to their neuroanatomical location.
mesh_terms: D000200:Action Potentials; D001921:Brain / Q000503:physiopathology*; D004292:Dominance, Cerebral; D006801:Humans; D010465:Perception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology