title: Alaproclate affects membrane ion channels in GH3/B6 pituitary cells.
abstract: Effects of alaproclate, an inhibitor of serotonin uptake, on the membrane of GH3/B6 clonal pituitary cells were studied using whole cell patch clamp recording techniques. Application of alaproclate (5 microM) depolarized the cell and increased the rheobase. Such treatment also increased the frequency of spontaneous firing. It is suggested that alaproclate decreases the potassium conductance in a manner similar to 4-aminopyridine and affects membrane calcium channels.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000631:Aminopyridines / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects*; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*
chemical_list: D000631:Aminopyridines; D000928:Antidepressive Agents; D007473:Ion Channels; C025293:alaproclate; D000409:Alanine