[Chemical structure and immunostimulating activity of high molecular weight polysaccharides].
An immunostimulating activity of high molecular polysaccharides, dissimilar in their chemical structure, was studied. Inoculation of mice with bacteria of typhoid fever and Kl. pneumoniae demonstrated that O-polysaccharide from typhoid bacteria--multicomponent, branch-chained, phosphorus-containing polysaccharide--exhibited the highest immunostimulating effect. Mannans and glucans, with linear and branch-chained molecules, involving various types of C-C bonds, had lower stimulating properties, which did not correlate with the level of a molecule branching and the type of C-C bonds. These data were confirmed after evaluation of adjuvant properties of high molecular polysaccharides with sheep erythrocytes and their ability to activate macrophages.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D007113:Immunity, Innate; D007114:Immunization; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008970:Molecular Weight; D019081:O Antigens; D011134:Polysaccharides / Q000032:analysis / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D019081:O Antigens; D011134:Polysaccharides
Khimicheskaia struktura i immunostimuliruiushchaia aktivnost' vysokomolekuliarnykh polisakharidov.