[Effect of the synthetic preparation B 58 on the activity of natural killer and cytostatic cells of the mouse spleen].
The effect of the in vivo treatment with synthetic interferon inducer B-58 on natural killer (NK) and cytostatic cell activity was studied in CBA and A/Sn mice. A marked increase in NK cell activity against target cells YAC-1 was observed in the spleen of CBA mice within 4 days after treatment. On the other hand, NK activity in A/Sn mice was not affected by B-58. However, B-58 was shown to enhance cytostatic cell activity both in CBA and A/Sn mice, when tested against target cells P 815.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000097:blood; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D007369:Interferon Inducers; D007376:Interleukin-2; D003208:Concanavalin A; D007372:Interferons
Vliianie sinteticheskogo preparata B 58 na aktivnost' normal'nykh killernykh i tsitostaticheskikh kletok selezenki myshi.