Anticoagulant substance released from human lung mast cells by stimulation with anti-IgE or Ca-ionophore A23187.
A significant amount of anticoagulant substance was released along with histamine, when human lung mast cells were stimulated with anti-IgE and Ca-ionophore A23187. Its activity was lost by heparinase, not by chondroitin-ABC lyase or chondroitin-AC lyase, and also inhibited by Polybrene, suggesting it would be heparin.
D000991:Antithrombins / Q000032:analysis; D001777:Blood Coagulation; D000001:Calcimycin / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008168:Lung / Q000378:metabolism*; D008407:Mast Cells / Q000378:metabolism*
D000991:Antithrombins; D007073:Immunoglobulin E; D000001:Calcimycin; D006493:Heparin