title: [L-glutamate-activated membrane conductance of spinal cord nerve cells during the early embryogenesis of the chicken].
abstract: Transient and steady-state L-glutamate-activated membrane currents were investigated by means of intracellular perfusion, voltage clamp techniques and concentration clamp in spinal cord neurons of 6-11 day chick embryos. The Hill coefficient was found to equal 1 for transient and 2 for steady-state components. Concentration of L-glutamate evoking half effect decreased during development more than 10 times for the steady-state component whereas it remained constant for the transient component. Existence of two types of glutamate-activated receptors in the membrane of spinal cord neurons at early stages of embryonic development is supposed.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007473:Ion Channels / Q000187:drug effects*; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000032:analysis; D013116:Spinal Cord / Q000032:analysis / Q000187:drug effects* / Q000196:embryology
chemical_list: D005971:Glutamates; D007473:Ion Channels; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid
vernacular_title: L-glutamataktiviruemaia provodimost' membrany nervnykh kletok spinnogo mozga v rannem émbriogeneze kuritsy.