Some effects of oestrogens on [3H]-mepyramine binding in rat brain.
Oestrogen depress [3H]-mepyramine binding in the amygdala, hypothalamus and cerebral cortex of rats. These effects of oestrogens are prevented by concurrent administration of inhibitors of cyclic 3'5' AMP phosphodiesterase, suggesting that the hormones act by reducing the activity of adenylate cyclase.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008297:Male; D010052:Ovariectomy; D011738:Pyrilamine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects* / Q000378:metabolism
D000631:Aminopyridines; D004967:Estrogens; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011738:Pyrilamine; D015056:1-Methyl-3-isobutylxanthine