The reactivity of mast cells in nasal mucosa--comparison between allergic and nonallergic disease.
The difference in the non-specific reactivity of lamina propria mast cells in the nasal mucosa of nasal allergy and nonallergic disease was studied. When the nasal mucosa was incubated in three kinds of histamine releasers, the rate of histamine release and that of mast cell degranulation were not statistically different between nasal allergy and nonallergic disease. In the presence of buffer alone, the rate of histamine release did not show the statistical difference between two diseases. However, in the same condition, the degranulation of mast cells in the case of nasal allergy was more than that of nonallergic nasal disease. These results show that the degranulation of mast cells in nasal allergy was more than that in nonallergic nasal disease in the living body. As for non-specific hypersensitivity in the case of nasal allergy, it is considered that one factor is the release of chemical mediators induced by an interaction between allergen and IgE antibodies on the cell membrane of mast cells.
D000293:Adolescent; D000328:Adult; D002648:Child; D003594:Cytoplasmic Granules / Q000473:pathology; D006636:Histamine Release; D006801:Humans; D008407:Mast Cells / Q000502:physiology* / Q000648:ultrastructure; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology / Q000503:physiopathology*; D009668:Nose Diseases / Q000473:pathology / Q000503:physiopathology*; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology / Q000503:physiopathology*