Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413.
The effect of KB-2413 on IgE-mediated histamine and LTC4 release from leukocytes obtained from asthmatic patients who were sensitive to mites, and from human lung tissues passively sensitized with IgE myeloma serum was studied. KB-2413 inhibited the IgE-mediated chemical mediator release concentration dependently at a range of 10(-4) to 3 x 10(-3) M. KB-2413 did not enhance histamine release at a higher concentration unlike ketotifen. These findings suggest that the inhibitory effect of KB-2413 on the release of chemical mediators contributes to the anti-allergic activity of this compound.
D001562:Benzimidazoles / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013189:SRS-A / Q000378:metabolism*
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D013189:SRS-A; D007073:Immunoglobulin E; C043345:emedastine