[Effect of the carcinogenic metabolites of aromatic amino acids on oxidative processes in lipids in vitro and in vivo].
A comparative study of the effect produced by endogenous carcinogens (p-hydroxyphenyllactic and 5-methoxyindole-3-acetic acids) and their non-cancerogenic analogues on lipid peroxidation in vitro and in vivo was performed. It has been found that cancerogenic tyrosine and serotonin metabolites, unlike their non-cancerogenic analogues, increase lipid peroxidation in vitro. In vivo, cancerogenic tyrosine metabolite--p-hydroxyphenyllactic acid--is capable both of increasing and decreasing antioxidative lipid activity in the animal liver.
D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D002273:Carcinogens; D008054:Lipid Peroxides; D010666:Phenylpropionates; C001418:4-hydroxyphenyllactic acid; D012701:Serotonin; C001736:5-methoxyindoleacetic acid; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid
Vliianie kantserogennykh metabolitov aromaticheskikh aminokislot na okislitel'nye protsessy v lipidakh in vitro i in vivo.