Neurotransmitter changes in cerebrospinal fluid in the Spanish toxic oil syndrome: human clinical findings and experimental results in mice.
Patients with Spanish Toxic Oil Syndrome (TOS) complaining of neuromuscular symptoms had increased levels of homovanillic acid and 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid. Severity of pain and muscle cramps correlated with the magnitude of increment in levels of monoamine metabolites. Mice treated with oleyl anilide, a putative toxic compound found in some stocks of the toxic rapeseed oil, did not present clinical or anatomical findings compatible with TOS. However, biochemical studies in these mice revealed a depletion of serotonin and an elevation of 5-HIAA levels. Our findings suggest that the unidentified toxic agent of the TOS and oleyl anilide induce pharmacological changes in monoamine neurons of the brain.
D000813:Anilides / Q000633:toxicity*; D000818:Animals; D001923:Brain Chemistry; D001937:Brassica; D002395:Catecholamines / Q000032:analysis; D004195:Disease Models, Animal; D005517:Foodborne Diseases / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D051379:Mice; D009821:Oils / Q000506:poisoning*; D009829:Oleic Acids / Q000633:toxicity*; D010146:Pain / Q000134:cerebrospinal fluid
D000813:Anilides; D002395:Catecholamines; D009821:Oils; D009829:Oleic Acids; D006897:Hydroxyindoleacetic Acid; C038731:oleoylanilide; D006719:Homovanillic Acid