Carrier-specific induction of suppressor cells controlling anti-erythrocyte autoantibody production in mice.
Mice immunized with rat erythrocytes develop anti-erythrocyte autoantibodies, distinct anti-rat erythrocyte agglutinins, and suppressor-inducer cells, which regulate the production of autoantibody but not anti-rat erythrocyte agglutinins upon transfer to naive recipients. In this report, we have tried to determine the specificity of the suppressor-inducer cells. CBA/N mice (which express an X-linked genetic B-lymphocyte defect) immunized with rat erythrocytes developed no autoantibodies but normal levels of anti-rat erythrocyte antibodies and suppressor-inducer cells, thereby suggesting that neither idiotypes on autoreactive B cells nor idiotypes on autoantibody itself, stimulate suppressor-inducer cells. In contrast, rat erythrocyte-primed spleen cells suppressed both a primary 2,4,6 trinitrophenyl (TNP) response and anti-erythrocyte autoantibody production (but not anti-rat erythrocyte antibodies) upon transfer to naive recipients and challenge with TNP-rat erythrocytes. It is considered that the suppressor-inducer cells are carrier-specific and that they are not stimulated by idiotypes on either autoantibody or autoreactive B cells.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001789:Blood Group Antigens / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D017707:Erythrocyte Transfusion; D005260:Female; D006241:Haptens / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D001323:Autoantibodies; D001789:Blood Group Antigens; D002352:Carrier Proteins; D000939:Epitopes; D006241:Haptens; D014301:Trinitrobenzenes