Immunopathology of cutaneous graft-versus-host disease.
Graft-versus-host disease (GVHD) occurs when lymphoid cells from an immunocompetent donor are introduced into a histoincompatible recipient that is incapable of rejecting them. GVHD is seen most commonly as a complication of therapeutic bone marrow transplantation, and the skin is a primary target organ. As GVHD mimics several important skin diseases both clinically and histologically, it provides a useful model for studying the immunopathologic features of epidermal cell-lymphocyte interactions.
D000818:Animals; D004817:Epidermis / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology; D006801:Humans; D007633:Keratins; D007801:Langerhans Cells / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D006681:HLA-D Antigens; D007633:Keratins