title: On the theoretical prediction of protein antigenic determinants from amino acid sequences.
abstract: The applicability range of a modified version of the Hopp-Woods model for the determination of protein antigenic determinants is estimated by comparing experimental data based on monoclonal and polyclonal antibodies. The results indicate a close correlation between the hydrophilicity of protein regions and their antigenicity. The efficiency of various hydrophilicity/hydrophobicity scales for the amino acid side chains is tested. A comment on the recognition factor concept of Fraga is given.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000939:Epitopes / Q000032:analysis*; D009113:Muramidase / Q000032:analysis; D009211:Myoglobin / Q000032:analysis; D011506:Proteins / Q000032:analysis* / Q000276:immunology; D014027:Tobacco Mosaic Virus / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis; D014907:Whales / Q000097:blood
chemical_list: D000939:Epitopes; D009211:Myoglobin; D011506:Proteins; D014764:Viral Proteins; D009113:Muramidase