The association of HLA and immune responses to bovine collagen implants.
The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.
D000818:Animals; D002417:Cattle; D003094:Collagen / Q000276:immunology*; D000939:Epitopes; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015235:HLA-B Antigens; D015804:HLA-DR4 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D019736:Prostheses and Implants / Q000009:adverse effects*
D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens; C035270:HLA-B5 antigen; D015804:HLA-DR4 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II; D003094:Collagen