Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat.
This study examines the effects of somatocrinin (GRF) and somatostatin antiserum (ASS), jointly and separately on gastric and duodenal growth. 24-day-old rats received twice daily SC injections of saline or GRF (4 and 20 micrograms X kg-1) for 14 days. ASS was given IP every 2 days. Alone, GRF increased gastric fundus weight concomitantly with DNA, RNA and protein contents producing hyperplasia and hypertrophy within this gland. Alone, ASS increased RNA and protein cellular concentrations. Joint ASS and GRF treatment stabilized the weight and protein content of the fundus, while reducing RNA contents as well as RNA and protein concentrations. GRF alone caused significant increments in duodenal weight and protein content suggesting cellular hypertrophy. Growth hormone, gastrin, cholecystokinin and secretin may be considered as putative mediators of these trophic effects.
D000818:Animals; D004247:DNA / Q000378:metabolism; D004386:Duodenum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000037:antagonists & inhibitors*; D013270:Stomach / Q000187:drug effects* / Q000254:growth & development
D010446:Peptide Fragments; D011506:Proteins; D013004:Somatostatin; D012313:RNA; D013006:Growth Hormone; D004247:DNA; D013007:Growth Hormone-Releasing Hormone