Anomalous rectification in rat locus coeruleus neurons.
Rat locus coeruleus neurons recorded under current clamp conditions show anomalous rectification (AR) as indicated by a progressive decrease in slope resistance measured with hyperpolarizing current pulses of increasing amplitude. AR was most prominent at potentials more negative than the K+ equilibrium potential. AR was strongly dependent on external K+ concentration and was blocked by external Ba2+ and Cs+, and intracellular injection of acetate.
D000818:Animals; D001464:Barium / Q000494:pharmacology; D002463:Cell Membrane Permeability; D002586:Cesium / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D002586:Cesium; D001464:Barium; D012964:Sodium; D011188:Potassium