[Effect of terrilytin on tissue bacteriostatic activity in the chemotherapy of renal and female genital tuberculosis in an experiment].
The effect of terrilytin on the bacteriostatic activity of the tissues (BAT) under conditions of antibacterial therapy was studied on experimental models of tuberculosis of the kidneys and female genitalia in 46 rabbits. It was shown statistically that terrilytin promoted an increase in the BAT and might be used as an agent increasing the effect of antibacterial therapy of tuberculosis. The level of the increase of the BAT depended on its initial level which was inversely proportional to the level of the lesions. At the same time the effect of terrilytin was directly proportional to the level of these lesions unfavourable for the drug penetration into the tissues and tuberculous foci. The results of the study are promising in increasing the efficacy of antibacterial therapy of extrapulmonary tuberculosis of the above localizations by the use of terrilytin.
D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors; D014384:Tuberculosis, Female Genital / Q000188:drug therapy* / Q000276:immunology; D014398:Tuberculosis, Renal / Q000188:drug therapy* / Q000276:immunology
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D004338:Drug Combinations; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Vliianie terrilitina na bakteriostaticheskuiu aktivnost' tkaneĭ pri khimioterapii tuberkuleza pochek i zhenskikh polovykh organov v éksperimente.