Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin.
Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.
D000818:Animals; D001923:Brain Chemistry; D004743:Enkephalin, Leucine / Q000032:analysis; D004744:Enkephalin, Methionine / Q000032:analysis; D005625:Frontal Lobe / Q000032:analysis; D008297:Male; D015288:Neurokinin A; D009479:Neuropeptides / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000378:metabolism*; D013373:Substance P / Q000032:analysis; D013681:Tegmentum Mesencephali / Q000032:analysis
D009479:Neuropeptides; D013373:Substance P; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D015288:Neurokinin A