In vivo induction of Ia antigens on rat keratinocytes by gamma-interferon.
Recombinant rat IFN-gamma was found to induce Ia antigen expression on rat keratinocytes in vivo. Strong expression of Ia antigen on keratinocytes of rat ears was produced after intradermal injections of 10,000 U IFN-gamma once daily on 3 successive days. The expression was still pronounced 2 days after the last injection, but had disappeared 4 days later.
D000818:Animals; D002465:Cell Movement; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D007633:Keratins / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D000949:Histocompatibility Antigens Class II; D007633:Keratins; D007371:Interferon-gamma