Bleomycin for the cure of Trypanosoma brucei brucei infections in mice: lack of pulmonary toxicity.
Although bleomycin is a known pulmonary toxin, results presented herein indicate its relative safety for treatment of trypanosomiasis. More than 4 times the curative dose in this acute model of infection does not induce significant alterations of lung hydroxyproline levels, which are known to directly correlate with histopathological criteria of pulmonary fibrosis.
D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use / Q000633:toxicity*; D006909:Hydroxyproline / Q000032:analysis; D008168:Lung / Q000032:analysis / Q000187:drug effects*; D051379:Mice; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D001761:Bleomycin; D006909:Hydroxyproline