title: Type-specific monoclonal antibodies produced to proteins of Murray Valley encephalitis virus.
abstract: Two monoclonal antibodies have been produced to the flavivirus, Murray Valley encephalitis (MVE). Immunofluorescent antibody and ELISA tests revealed that one antibody was specific for MVE while the other cross-reacted weakly with Alfuy and Kunjin viruses. These antibodies have neither haemagglutination inhibition nor neutralising activity. One of the monoclonal antibodies reacted with the envelope glycoprotein (E) and a 45,000 MW protein, while the other reacted with a protein of 23,000 daltons. Competitive binding assays confirmed that these antibodies reacted with unrelated epitopes.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology; D001667:Binding, Competitive; D000939:Epitopes / Q000276:immunology; D005416:Flavivirus / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D007074:Immunoglobulin G; D014764:Viral Proteins