6-Sulphanilamidoindazole-induced arthritis in rats: substance effects and acute-phase reaction.
Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-SAI arthritis, although on the whole the acute-phase reaction is relatively weak. The steroid dexamethasone and the nonsteroid benoxaprofen caused strong antiinflammatory activity at low doses. The data presented complete the picture of 6-SAI arthritis as a special inflammatory reaction in rats.
D000209:Acute-Phase Proteins / Q000097:blood; D000210:Acute-Phase Reaction / Q000209:etiology* / Q000517:prevention & control; D000818:Animals; D001168:Arthritis / Q000139:chemically induced* / Q000209:etiology / Q000517:prevention & control; D003907:Dexamethasone / Q000494:pharmacology; D005609:Free Radicals; D007249:Inflammation / Q000209:etiology*; D008297:Male; D010100:Oxygen; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D013424:Sulfanilamides
D000209:Acute-Phase Proteins; D005609:Free Radicals; D011422:Propionates; D013424:Sulfanilamides; C009347:6-sulfanilamidoindazole; C011677:benoxaprofen; D003907:Dexamethasone; D010100:Oxygen