[Qualitative and quantitative analysis of autoantibodies to the membrane antigens of erythrokaryocytes].
The study of the specificity, composition and concentration of autoantibodies (AB) active against erythrokaryocytes (EK) has been made by means of the enzyme immunoassay with sera obtained from patients. The specificity of AB embraces interspecific determinants of human, rabbit and mouse EK; determinants expressed on the EK of human and rabbit marrow; determinants expressed on human embryo EK. AB are mainly represented either by IgG or by IgM. Their quantitative evaluation permits the subdivision of sera into groups according to AB concentration. This phenomenon is due to the existence of the threshold value which, in most cases, sets the upper limit to the AB level detectable in the assay.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000032:analysis; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D000939:Epitopes / Q000276:immunology; D004910:Erythrocyte Membrane / Q000276:immunology*; D007114:Immunization / Q000379:methods; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D012217:Rheumatoid Factor / Q000032:analysis; D012995:Solubility
D000936:Antigen-Antibody Complex; D000941:Antigens; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor
Kachestvennyĭ i kolichestvennyĭ analiz autoantitel k antigenam membrany éritrokariotsitov.