The anion selectivity of the gamma-aminobutyric acid controlled chloride channel in the perfused spinal ganglion cell of frog.
The selectivity of the GABA-controlled Cl- channel in the membrane of the dorsal root ganglion cell of the frog has been measured in internally perfused cells by means of current and voltage clamp. When Cl- was replaced by various anions, the 10(-5) or 10(-4) M GABA-induced reversal potentials (EGABA) for Br-, I-, NO3-, ClO4-, SCN-, BF4- and ClO3- were more negative than that for Cl-, despite the fact that, in solution, the test anions are either larger than or similar in size to Cl-.
D000818:Animals; D000838:Anions; D002118:Calcium / Q000494:pharmacology; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000494:pharmacology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D011892:Rana catesbeiana; D012964:Sodium / Q000494:pharmacology; D014325:Tromethamine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000838:Anions; D002712:Chlorides; D007473:Ion Channels; D014325:Tromethamine; D002586:Cesium; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium