[Comparative study of the immunosuppressive properties of trophoblastic beta 1-glycoprotein and placental alpha 2-microglobulin in vitro].
It has been shown that trophoblastic beta 1-glycoprotein (TBG) and placental alpha 2-microglobulin (PAMG-2) in concentrations 60-120 micrograms/ml suppresses both the inductive and proliferative phase of unidirectional mixed lymphocyte reaction in mice, as well as proliferative responses to phytohemagglutinin or pokeweed mitogen. TBG protein was more effective. The proteins were not toxic for lymphocytes.
D000510:Alpha-Globulins / Q000494:pharmacology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003864:Depression, Chemical; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011257:Pregnancy Proteins / Q000494:pharmacology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000494:pharmacology*; D013997:Time Factors
D000510:Alpha-Globulins; D007166:Immunosuppressive Agents; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; C025500:alpha(2)-microglobulin
Sravnitel'noe izuchenie immunosupressivnykh svoĭstv trofoblasticheskogo beta 1-glikoproteida i platsentarnogo al'fa 2-mikroglobulina in vitro.