Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum.
Changes in substance P (SP)- and neurokinin A (NKA)-like immunoreactivity (LI) in the rat substantia nigra (SN) after striatal lesion produced by ibotenate were studied using immunohistochemical methods. Compared to the SN on the control side, both SP- and NKA-LI were dramatically depleted in the SN on the lesion side. These findings are consistent with the existence of SP- and/or NKA-containing neurons in the striatum projecting to the SN.
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D007051:Ibotenic Acid; D007150:Immunohistochemistry; D008297:Male; D015288:Neurokinin A; D009479:Neuropeptides / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000276:immunology*; D013378:Substantia Nigra / Q000276:immunology*
D009479:Neuropeptides; D007051:Ibotenic Acid; D013373:Substance P; D015288:Neurokinin A