Mouse beta-interferon reduces RNA efflux from isolated nuclei.
Treatments of isolated L929 cell nuclei with MuIFN-beta reduced the energy-dependent efflux of 3H-RNA from these nuclei in a dose-dependent manner. These observations provide evidence for a direct physiological effect of IFN on the cell nucleus.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism; D007370:Interferon Type I / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D012313:RNA / Q000378:metabolism*
D007370:Interferon Type I; D012313:RNA