The effects of the anaphylatoxins C3a and C5a on isolated mast cells from rat and man.
Of the complement peptides comprising anaphylatoxin activity, only C5a caused a very small (less than 1.5%) but statistically significant histamine release from isolated human adenoidal mast cells. C3a and the respective des-Arg-derivatives were found to be ineffective. In rat peritoneal mast cells, neither peptide caused histamine release.
D000818:Animals; D003176:Complement C3 / Q000494:pharmacology*; D015926:Complement C3a; D003182:Complement C5 / Q000494:pharmacology*; D015936:Complement C5a; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects*; D051381:Rats; D013045:Species Specificity
D003176:Complement C3; D003182:Complement C5; D015926:Complement C3a; D015936:Complement C5a