Selective blockade of components of potassium activation in Myxicola axons.
The K+ conductance in Myxicola giant axons activates in two phases which are pharmacologically separable. The fast phase of K+ activation is specifically inhibited by 4-aminopyridine and by the substitution of D2O for H2O. We suggest Myxicola giant axons, like the amphibian node of Ranvier, may possess more than one variety of K+ channel.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D003903:Deuterium; D017666:Deuterium Oxide; D004553:Electric Conductivity; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D007700:Kinetics; D011077:Polychaeta; D011188:Potassium / Q000494:pharmacology*; D014867:Water
D000631:Aminopyridines; D007473:Ion Channels; D014867:Water; D003903:Deuterium; D015761:4-Aminopyridine; D017666:Deuterium Oxide; D011188:Potassium