Complexation of copper(II) by a peptide hybrid of bleomycin and amsacrine. Circular dichroism and electron spin resonance studies.
A model incorporating the metal chelating moiety of bleomycin and an anilinoacridine ring able to intercalate in DNA has been synthesized. The copper(II) complex of that molecule has been studied using circular dichroism and electron spin resonance by comparison with bleomycin. The introduction of the anilinoacridine ring involves a modification in the geometry of the complex. A distortion of the square-pyramidal form (type II complex) gives rise to a type I complex in which the metallic atom is drawn out of the plane of the four square-planar ligands and displaced slightly towards the fifth ligand.
D001761:Bleomycin / Q000031:analogs & derivatives; D002942:Circular Dichroism; D004151:Dipeptides; D004578:Electron Spin Resonance Spectroscopy; D009942:Organometallic Compounds; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid
D004151:Dipeptides; D009942:Organometallic Compounds; C023502:copper bleomycin; D001761:Bleomycin; D005680:gamma-Aminobutyric Acid; C044370:copper(II)-methyl 2-(2-aminoethyl)aminoethylpyridine-6-carboxylhistidinate