[Calcium ion modulation of short-term plasticity of the cholinoreceptor membrane of the mollusk neuron].
Repeated iontophoretic acetylcholine applications to the external surface of the plasma membrane of identified Helix neurones elicit a gradual reversible reduction of cholinoreceptors (ChR) sensitivity. Influence on Ca-conductivity of neuronal membrane modifies the dynamics of lowering of ChR sensitivity. Administration of cadmium ions--blockader of Ca-conductivity, slows down and weakens ChR habituation, while Ca-conductivity activation by raising of extracellular Ca2+ content accelerates and deepens the habituation. It is suggested that chemo-controlled Ca-conductivity takes part in regulation of short-term ChR plasticity.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D009431:Neural Conduction; D009473:Neuronal Plasticity / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology
D007473:Ion Channels; D012701:Serotonin; D000109:Acetylcholine; D002118:Calcium
Moduliatsiia ionami kal'tsiia kratkovremennoĭ plastichnosti kholinoretseptivnoĭ membrany neĭronov molliuska.