[Combined therapy with high-dosage cisplatin and radiation in advanced ENT tumors (a phase-II study)].
The most promising method to obtain at least a palliative effect in advanced ORL tumors seems to be a combination of chemotherapy and radiotherapy. We made an attempt to reach a higher remission rate (n = 28) by means of an extraordinary high dose of cis-platinum and the usual maximum radiation dose of 60 Gy: The method had to be abandoned because the rates of success (CR and PR) decreased from 79% to 46% in eight months, the side effects, however, were beyond a tolerable degree. We are of the opinion that the same results can be obtained by less radical methods, too.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy / Q000379:methods; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D010166:Palliative Care / Q000379:methods; D010347:Patient Care Planning; D011879:Radiotherapy Dosage; D013997:Time Factors
D002945:Cisplatin
Kombinierte Therapie von hochdosiertem Cis-Platin und Bestrahlung bei fortgeschrittenen HNO-Tumoren (Phase-II-Studie).