[Effect of tetrodotoxin in low concentrations on the ion currents of trigeminal ganglion neurons in the rat].
Isolated neurons from trigeminal ganglia of one-month-old rats were studied under conditions of intracellular perfusion and voltage clamp. Increase of the inward current amplitude and deceleration of current decay due to the action of low external concentrations of tetrodotoxin (10(-12)-10(-10) M) were observed in a number of the cells tested. Such changes were absent in chloride-free extracellular solution. The existence of a transient potential-dependent current carried by chloride anions through tetrodotoxin-sensitive chloride channels in the membrane of trigeminal ganglion neurons is postulated.
D000818:Animals; D002712:Chlorides / Q000378:metabolism; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008838:Microcomputers; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology*; D012668:Trigeminal Ganglion / Q000187:drug effects*; D014276:Trigeminal Nerve / Q000187:drug effects*
D002712:Chlorides; D007473:Ion Channels; D013779:Tetrodotoxin
Vliianie tetrodotoksina v nizkikh kontsentratsiiakh na ionnye toki neĭronov trigeminal'nogo gangliia krys.