Interferon induction in piglets with polyinosinic:polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose.
When newborn piglets were inoculated intravenously with 1.0, 0.5 or 0.25 mg kg-1 of polyinosinic:polycytidylic acid (poly I:C) complexed with poly-L-lysine and carboxymethylcellulose (poly ICLC), the highest serum interferon levels and the lowest white blood cell counts were found in response to a dose of 0.5 mg kg-1. Similar responses were observed in weaned piglets inoculated with 0.25 mg kg-1 of poly ICLC. Poly ICLC was a more effective interferon inducer than poly I:C, particularly in newborn piglets.
D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology* / Q000031:analogs & derivatives; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000097:blood*; D007958:Leukocyte Count / Q000662:veterinary; D008747:Methylcellulose / Q000031:analogs & derivatives*; D011070:Poly I-C / Q000494:pharmacology*; D011107:Polylysine / Q000494:pharmacology* / Q000031:analogs & derivatives; D013552:Swine / Q000097:blood*
D007369:Interferon Inducers; D011107:Polylysine; C019531:poly ICLC; D008747:Methylcellulose; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C