Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.
We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000502:physiology*; D002450:Cell Communication; D002478:Cells, Cultured; D007365:Intercellular Junctions / Q000502:physiology*; D009154:Mutation; D011120:Polyomavirus / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D016392:Proto-Oncogene Proteins pp60(c-src); D051381:Rats; D013696:Temperature
D000957:Antigens, Viral, Tumor; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)