The homology of complement factor C8 gamma chain and alpha-1-microglobulin.
The sequence of the complement factor C8 gamma chain shares a remarkable degree of similarity with that of alpha-1-microglobulin, a member of the alpha-2u-globulin superfamily. This superfamily comprises a diverse group of distantly related animal proteins possessing characteristic structural features and similar functions. Comparison of the C8 gamma chain with these proteins supports its homology to them and suggests a possible functional role.
D000510:Alpha-Globulins; D000595:Amino Acid Sequence; D003185:Complement C8; D003545:Cysteine; D004220:Disulfides; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D013329:Structure-Activity Relationship
D000510:Alpha-Globulins; D003185:Complement C8; D004220:Disulfides; C016001:alpha-1-microglobulin; D003545:Cysteine