title: [Analysis of long-lived substates of the conductivity of single ion channels].
abstract: Using the patch-voltage-clamp method kinetic parameters of single ionic channels were studied. It was found that the channels have long-lasting conductance substates along with the short-living ones. The conductance of a long-lasting substate fluctuates near an average sublevel in the boundaries of a restrict number (k) of elementary conductance steps. There is a direct relationship: the greater k, the longer is average duration (tau k) of the substate. For a given k the falling phase of tau k value distribution is approximately one-exponential. The substates of k-th order result in the multi-exponentiality of the ion current kinetics.
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008195:Lymnaea; D008564:Membrane Potentials; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D013997:Time Factors
chemical_list: D007473:Ion Channels
vernacular_title: Analiz dolgozhivushchikh podsostoianiĭ provodimosti odinochnykh ionnykh kanalov.