Ethanol-induced hypothermia and biogenic amine metabolites.
Ethanol is known to cause hypothermia. The rectal temperature of rats receiving ethanol, 4 g/kg i.p., at an ambient temperature of 23 degrees C decreased by 2 degrees C. This body temperature decrease could be prevented by keeping the animals at an ambient temperature of 34 degrees C. Irrespective of the body temperature it was found that the concentration of the major metabolites of dopamine and serotonin in brain tissue was significantly increased. Thus, the change in brain monoamine metabolite levels in rats after administration of ethanol are not due to ethanol-induced hypothermia.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D015102:3,4-Dihydroxyphenylacetic Acid; D000431:Ethanol; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid