Highly immunogenic artificial complexes based on synthetic immunopotentiating polyions (artificial antigens and vaccines).
An interpretive review of the theoretical and experimental data on the immunogenetic concept that "there are no strong and weak antigens, there are high and low responder genotypes," developed and upheld by the authors is presented. To achieve phenotypic correction (finding ways of turning genetically low responder individuals into high responder ones) the authors have developed complex antigens--artificial macromolecular complexes containing both the required antigenic determinants and adjuvant structures. Synthetic nonnatural carbohydrates and heterochain polyions with controlled structure (PAA, PVP, polyconidine quarternary salts) were shown to act as immunopotentiators, substituting the helper signal of T-cells. The authors' data confirm this immunogenetic principle for developing highly immunogenic preparations, prototypes of future vaccines.
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002241:Carbohydrates / Q000138:chemical synthesis / Q000276:immunology*; D000939:Epitopes / Q000138:chemical synthesis / Q000276:immunology; D006389:Hemagglutinins, Viral / Q000276:immunology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000276:immunology*; D007125:Immunogenetics; D051379:Mice; D008968:Molecular Conformation; D009439:Neuraminidase / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology; D051381:Rats; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014763:Viral Matrix Proteins; D014764:Viral Proteins / Q000276:immunology
D000276:Adjuvants, Immunologic; D000941:Antigens; D002241:Carbohydrates; D000939:Epitopes; D006389:Hemagglutinins, Viral; D006571:Heterocyclic Compounds; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D009439:Neuraminidase