The molecular actions of beta-agonists in the cardiac sarcolemma.
Although alpha-receptors are known to exist in the myocardium, the predominant effect of catecholamines on the force of contraction of the heart is mediated through beta-receptors. This review deals only with the latter, and is particularly concerned with the sarcolemmal molecular mechanisms by which beta-stimulation increases the rate of cyclic adenosine monophosphate (cAMP) production by adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D006153:Guanosine Diphosphate / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012508:Sarcolemma / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D006153:Guanosine Diphosphate; D000262:Adenylyl Cyclases