title: Elevated alpha-fetoprotein in pregnancy complicated by aplasia cutis after exposure to methimazole.
abstract: A case of aplasia cutis after exposure to methimazole (Tapazole) in early pregnancy is described. Elevated maternal serum alpha-fetoprotein (MSAFP) and amniotic fluid alpha-fetoprotein (AFP) were found. Elevated MSAFP and amniotic fluid AFP in women exposed to methimazole may suggest this rare fetal condition.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000378:metabolism*; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000175:diagnosis / Q000378:metabolism*; D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D011247:Pregnancy; D012535:Scalp / Q000002:abnormalities*; D012886:Skull / Q000002:abnormalities*; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins; D008713:Methimazole