Quinolinic and kainic acids can enhance calcitonin gene-related peptide-like immunoreactivity in striatal neurons with substance P-like immunoreactivity.
Quinolinic or kainic acid, when injected into the cat striatum, caused neurodegenerative changes in striatal neurons. In parallel with these changes, however, calcitonin gene-related peptide-like immunoreactivity became visible in perikarya of many striatal neurons which were distributed around the lesions produced by the quinolinic or kainic acid injections. The vast majority of these lesion-spared neurons showing calcitonin gene-related peptide-like immunoreactivity were striatal neurons with substance P-like immunoreactivity.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002415:Cats; D002421:Caudate Nucleus / Q000032:analysis / Q000166:cytology / Q000187:drug effects; D003342:Corpus Striatum / Q000032:analysis* / Q000166:cytology / Q000187:drug effects; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D009479:Neuropeptides / Q000032:analysis*; D011691:Puromycin / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D013373:Substance P / Q000032:analysis*
D009479:Neuropeptides; D011725:Pyridines; D011805:Quinolinic Acids; D013373:Substance P; D011691:Puromycin; D017378:Quinolinic Acid; D015740:Calcitonin Gene-Related Peptide; D007608:Kainic Acid