title: Effects of hydroxyethylstarch (Hespan), a plasma expander, on the functional activity of the reticuloendothelial system. Comparison with human serum albumin and pyran copolymer.
abstract: The purpose of the present investigation was to determine if RES activity was altered after the infusion (bolus i.v. injection over approximately 3-5 min) of hydroxyethylstarch (HES). RES function was determined by vascular clearance of 51Chromium-labeled sheep erythrocytes and the subsequent uptake into the liver, spleen, lungs, and thymus at 1 hr, 3 hr, 6 hr, 1 day, 3 days, and 7 days post infusion. Infusion with the low doses of HES (20 and 40 ml/kg) produced changes in vascular clearance which were comparable to physiological saline. Infusion with 80 ml/kg HES produced a biphasic response with a modest suppression of vascular clearance (i.e., 151% increase in half life) and hepatic phagocytosis (50%) during the first 6 hours after injection, followed by recovery at 24 hours and a stimulation in hepatic uptake (42%) after 3 days. These effects by HES were compared to those produced by infusion with 80 ml/kg HSA, a comparable colloid and with 80 ml/kg pyran copolymer, a positive control.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006895:Hydroxyethyl Starch Derivatives / Q000633:toxicity*; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011108:Polymers / Q000633:toxicity*; D011713:Pyran Copolymer / Q000633:toxicity*; D012709:Serum Albumin / Q000494:pharmacology*; D012756:Sheep; D013213:Starch / Q000031:analogs & derivatives*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D011108:Polymers; D012709:Serum Albumin; D011713:Pyran Copolymer; D013213:Starch