Myelin proteolipid protein induces demyelinating disease in mice.
Using two methods of immunization (A and B), 5/10 (A) and 27/45 (B), BALB/c by J mice immunized with human myelin proteolipid protein developed a demyelinating disease with a spectrum of chronic progressive to relapsing-remitting courses. Demyelinative lesions were seen histopathologically in all clinically affected animals that were examined. Many of the clinically unaffected animals also had histopathologic evidence of demyelination. Some of the animals had evidence of multiple ages of foci of activity. Evidence is presented that contamination with myelin basic protein could not account for the disease. This is a new model for multiple sclerosis in mice.
D000818:Animals; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D006968:Hypersensitivity, Delayed; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D004676:Myelin Basic Protein / Q000378:metabolism; D009185:Myelin Proteins / Q000276:immunology*; D018991:Myelin Proteolipid Protein; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology
D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein