title: Effects of aluminium chloride on cultured cells from rat brain hemispheres.
abstract: Neurofilamentous tangles have been induced by aluminium chloride in rat brain neurons cultivated on astroglial feeder layers. Monoclonal antibodies to neurofilaments were found to stain these aluminium-induced tangles. Immunostaining of these structures with anti-paired helical filament serum was always negative, though good staining of neuronal perikarya was achieved. This observation supports the hypothesis that aluminium-induced tangles are made up of neurofilament proteins. These tangles appear to be distinct immunochemically from Alzheimer-paired helical filaments.
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D002712:Chlorides / Q000494:pharmacology*; D003599:Cytoskeleton / Q000473:pathology*; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007382:Intermediate Filaments / Q000187:drug effects / Q000473:pathology*; D016900:Neurofilament Proteins; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D012834:Silver; D013194:Staining and Labeling
chemical_list: D017607:Aluminum Compounds; D000911:Antibodies, Monoclonal; D002712:Chlorides; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D009498:Neurotoxins; D000077410:Aluminum Chloride; D012834:Silver; D000535:Aluminum