title: [RNA-synthesizing activity in the liver of rats after a flight on the Kosmos 1667 biosatellite].
abstract: The effect of a short-term flight (7 days) on the RNA synthetic activity in isolated nuclei of the rat liver and its content of nucleic acids was investigated. Postflight the activity of RNA-polymerase, the key enzyme of RNA synthesis, increased. The endogenous synthesis of RNA in nuclei grew, probably, due to the change in the activity of RNA-polymerase. Conversely, the concentration of nucleic acids in the liver tended to decrease. The results obtained give evidence that the changes in the RNA synthetic apparatus of hepatocytes in short-term flights are similar in sign to those seen in long-term flights.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013997:Time Factors; D014586:USSR
chemical_list: D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases
vernacular_title: RNK-sinteziruiushchaia aktivnost' v pecheni krys posle poleta na biosputnike "Kosmos-1667".