title: [Antibacterial activity of a number of preparations and their combination with a proteolytic enzyme against the microflora of burn and surgical wounds].
abstract: Antibacterial activity of antibiotics (azlocillin, tobramycin and piperacillin), antiseptics (metacid, chlorhexidine and quinosoline) and some other drugs (dioxidine and mafenide acetate) against the main representatives of the burn and surgical wound microflora, i. e. Staphylococcus, P. aeruginosa, Proteus, Providencia, Serratia, Klebsiella and E. coli was studied. Tobramycin and piperacillin were highly active against P. aeruginosa, Staphylococcus and Proteus. It was shown that in the presence of terrilytin, a proteolytic enzyme the activity of the combinations of chlorhexidine with dioxidine or mafenide acetate against all microorganisms occurring in burn and surgical wounds markedly increased.
mesh_terms: D000287:Administration, Topical; D000681:Amylases / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002056:Burns / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
vernacular_title: Antibakterial'naia aktivnost' riada preparatov i ikh kombinatsiĭ s proteoliticheskim fermentom v otnoshenii mikroflory ozhogovoĭ i khirurgicheskoĭ ran.