Phospholipids as components of the nuclear matrix: their possible biological significance.
The phospholipid involvement in the regulation of the functional and structural properties of the nuclear matrix is discussed analysing the results obtained with the enzymic removal of these molecules. Namely phospholipids seem to mediate hydrophobic interactions between nucleic acids and matrix fibrils either directly or indirectly through an association with the non-histone proteins of the matrix.
D000818:Animals; D002458:Cell Fractionation; D002467:Cell Nucleus / Q000032:analysis / Q000378:metabolism* / Q000648:ultrastructure; D004247:DNA / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000032:analysis; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000648:ultrastructure; D051379:Mice; D010743:Phospholipids / Q000502:physiology*; D012313:RNA / Q000378:metabolism; D051381:Rats; D014158:Transcription, Genetic; D010738:Type C Phospholipases / Q000378:metabolism
D008055:Lipids; D010743:Phospholipids; D012313:RNA; D004247:DNA; D010738:Type C Phospholipases; D004121:Dimethyl Sulfoxide