Innervation of substance P neurons by catecholaminergic terminals in the neostriatum.
In this study we tried to establish by the electron microscopic 'mirror technique' whether substance P-like immunoreactive neurons in the neostriatum receive synaptic inputs from catecholaminergic, presumably dopaminergic, nigrostriatal axons. Tyrosine hydroxylase-immunoreactive (TH-IR) axonal boutons were in synaptic contact with the somas and proximal dendrites of SP-IR neostriatal neurons, which are medium in size and have unindented nuclei. This suggests that nigrostriatal dopaminergic neurons monosynaptically influence the strionigral substance P neurons.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism / Q000502:physiology*; D003342:Corpus Striatum / Q000032:analysis / Q000166:cytology* / Q000502:physiology; D008297:Male; D009411:Nerve Endings / Q000032:analysis / Q000502:physiology*; D009474:Neurons / Q000032:analysis / Q000145:classification / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*; D013569:Synapses / Q000032:analysis / Q000502:physiology
D002395:Catecholamines; D013373:Substance P