TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies.
The monoclonal antibodies (MoAbs) A10/13 and IIB3 were studied in parallel with routine HLA-DR typings. The specificities TA10 and 2B3, recognized by A10/13 and IIB3 MoAb, respectively, showed clear segregation in families and never occurred together on the same haplotype. TA10 and 2B3 appeared to be in perfect Hardy-Weinberg equilibrium. The TA10 specificity is DQw3 related and is in linkage disequilibrium with DR5 (DRw11 and DRw12) and it is also weakly associated with DR4. The 2B3 specificity is DQw1 related and it is in linkage disequilibrium with DR2, DR4, DRw9, and DRw13. The 2B3 and TA10 specificities appear to be alleles of a polymorphic system, closely related, but different from HLA-DQ.
D000483:Alleles; D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D000939:Epitopes / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II