title: [Toxico-pharmacological properties of 6-azacytidine].
abstract: An antitumor drug 6-azacytidine, being an inhibitor of nucleic metabolism, has a broad spectrum of the antiblastic action. During the study of its pharmacological properties it proved to be low toxic, to exert a mild action on hemopoiesis, to fail to suppress the liver antitoxic function, to have a high chemotherapeutic index and a broad spectrum of the therapeutic action, to exert no local irritant effect on the skin and mucosae of the eye, to possess a sufficiently high reversibility of the toxic action.
mesh_terms: D000818:Animals; D001374:Azacitidine / Q000494:pharmacology / Q000506:poisoning / Q000633:toxicity* / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D001374:Azacitidine; C040881:6-azacytidine
vernacular_title: Nekotorye toksiko-farmakologicheskie svoĭstva 6-azatsitidina.