Effect of various GABA-receptor agonists and antagonists on anaphylactic histamine release in the guinea-pig ileum.
In this paper we confirm the previously reported inhibition by GABA of anaphylactic histamine release from isolated guinea-pig ileum longitudinal muscle. Moreover we report that: GABA-inhibition of anaphylactic histamine release is mimicked both by GABA-A and GABA-B agonists; both GABA-A and GABA-B antagonists are effective in reversing GABA's inhibitory effect; the effect is exerted specifically by GABA-ergic drugs: taurine and beta-alanine are ineffective; the GABA-ergic effect seems not to involve cholinergic and adrenergic transmission. It is concluded that it might be interesting to assess the clinical value of GABA-ergic drugs in allergic gut disorders.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001418:Baclofen; D003864:Depression, Chemical; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D007082:Ileum / Q000503:physiopathology*; D007539:Isonicotinic Acids; D008297:Male; D009130:Muscle, Smooth / Q000503:physiopathology*; D011963:Receptors, GABA-A / Q000502:physiology*; D013654:Taurine; D015091:beta-Alanine; D005680:gamma-Aminobutyric Acid
D007539:Isonicotinic Acids; D011963:Receptors, GABA-A; D015091:beta-Alanine; D013654:Taurine; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; C015300:isoguvacine