Modification of Na channels by synthetic dihydrobatrachotoxinin A-20 alpha-benzoate.
Sodium channels in nodal membrane modified by a synthetic analog of batrachotoxin, 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate, were studied under voltage clamp conditions. The voltage dependence of channel activation was shifted by 70-80 mV towards more negative potentials. Selectivity sequence determined from peak current reversal potential was as follows: Na:NH4:K = 1:0.46:0.23. Our data suggest that 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate has qualitatively similar effects on the properties of sodium channels as does natural batrachotoxin.
D000818:Animals; D001496:Batrachotoxins / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology; D009498:Neurotoxins; D011895:Rana ridibunda
D001496:Batrachotoxins; D007473:Ion Channels; D009498:Neurotoxins; C042797:7,8-dihydrobatrachotoxin A