Insulin-like growth factor-binding protein PP12 in ovarian cyst fluid.
Elevated levels of insulin-like growth factor-binding protein (IGF-bp) were recently found in the serum of patients with ovarian tumors. We studied the concentration of IGF-bp in cyst fluids of 37 women operated on for benign or malignant ovarian cysts. The levels were elevated (greater than 47 micrograms/l) in 6 of 28 benign, but in none of the nine malignant ovarian cysts. The highest IGF-bp concentration (447 micrograms/l) was observed in a benign serous cystadenoma.
D002352:Carrier Proteins / Q000378:metabolism*; D003536:Cystadenocarcinoma / Q000378:metabolism; D003537:Cystadenoma / Q000378:metabolism; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D010048:Ovarian Cysts / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism; D011257:Pregnancy Proteins / Q000378:metabolism*
D002352:Carrier Proteins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011257:Pregnancy Proteins