Correlation between tumor markers and tumor size.
Traditionally diagnosis of tumors is made by histopathology, because tumor markers are not sufficiently specific, and only low rates of positive cases have been observed. To induce free release of tumor markers into the blood, the IM injection of vitamin A and infrared-ray hyperthermia was used in 203 cancer patients. Blood samples were collected periodically to determine the levels of CEA, ferritin (FT), alpha-fetoprotein, sialic acid, and the ratio of ferritin to serum iron (FT/Fe). The analysis of each released tumor marker led to an increase in the rate of positive interpretations, indicating a linear correlation between tumor marker and tumor size. As a result of the evaluation of a combination assay of tumor markers using release induction, the rates of positive cases for any three of five markers were increased to 53, 65, and 94% in correlation with an increase in tumor size.
D002272:Carcinoembryonic Antigen / Q000032:analysis; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D019158:N-Acetylneuraminic Acid; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D012794:Sialic Acids / Q000097:blood; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000097:blood
D002272:Carcinoembryonic Antigen; D012794:Sialic Acids; D000509:alpha-Fetoproteins; D005293:Ferritins; D007501:Iron; D019158:N-Acetylneuraminic Acid