title: [Effect of proteolytic inhibitors from human plasma on the activity of native and immobilized terrilytin].
abstract: Human blood plasma inhibitors are studied for their effect on the activity of terrilytin, a proteolytic enzyme of microbial origin, and terridecase, its immobilized form. The main plasma inhibitor of terrilytin is alpha 2-macroglobulin (alpha 2 MG). The pattern of terrilytin and terridecase interaction with alpha 2 MG preparation isolated from human blood plasma has also been studied. The inhibitor is found to exert a slight retarding effect on the terridecase activity. Significant differences in alpha 2 MG inactivation of terrilytin and trypsin are observed.
mesh_terms: D000681:Amylases / Q000032:analysis*; D004338:Drug Combinations / Q000032:analysis; D004795:Enzyme Stability; D004800:Enzymes, Immobilized / Q000032:analysis*; D006801:Humans; D010447:Peptide Hydrolases / Q000032:analysis*; D011480:Protease Inhibitors / Q000097:blood*; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D004338:Drug Combinations; D004800:Enzymes, Immobilized; D011480:Protease Inhibitors; D000511:alpha-Macroglobulins; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
vernacular_title: Vliianie proteoliticheskikh ingibitorov plazmy krovi cheloveka na aktivnost' nativnogo i immobilizirovannogo terrilitina.