Effects of MPTP poisoning on central somatostatin and substance P levels in the mouse.
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) on the levels of the neuropeptides somatostatin and substance P, were examined in various brain regions of C57 mice. Two weeks after injections of MPTP (2 X 30, 2 X 40 and 2 X 50 mg/kg i.p.) a dose-dependent decrease in striatal catecholamine levels was observed. There was also a dose-dependent increase in nigral somatostatin immunoreactivity and no reduction in striatonigral substance P levels. These results are in contrast with the changes observed in peptide levels in post-mortem Parkinson's brains.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010302:Parkinson Disease, Secondary / Q000378:metabolism; D011725:Pyridines / Q000506:poisoning*; D011863:Radioimmunoassay; D013004:Somatostatin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D002395:Catecholamines; D011725:Pyridines; D013373:Substance P; D013004:Somatostatin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine