Absence of OKT4 antigen epitope: report of a case in a Brazilian population.
During the study of 162 normal subjects we found an 8 month-old black girl without previous illnesses, especially infections, whose lymphocytes did not react with OKT4 monoclonal antibody. However the CD4 subset was present, since the number of lymphocytes which reacted with Leu 3a and T4 was normal. In addition the percentage of Fc mu+ lymphocytes, K cell activity and PHA response were normal. The proportion of the other lymphocyte subsets did not differ from normal controls. Four first degree relatives of this child had a normal proportion of OKT4+ lymphocytes. The absence of OKT4 epitope was previously reported as a rare genetic variant which was detected only in Japanese and in subjects of black African ancestry.
D000954:Antigens, Surface / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D001938:Brazil; D000939:Epitopes / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification / Q000276:immunology
D000954:Antigens, Surface; D000956:Antigens, Viral; D000939:Epitopes