Synthetic peptide analogs to probe the immunological expression of the rat encephalitogenic neuropeptide.
The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given.
D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology; D006168:Guinea Pigs; D004676:Myelin Basic Protein / Q000032:analysis / Q000276:immunology*; D009479:Neuropeptides / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity; D051381:Rats; D011917:Rats, Inbred Lew; D013045:Species Specificity
D004676:Myelin Basic Protein; D009479:Neuropeptides