Elevated levels of serum pancreatic secretory trypsin inhibitor (PSTI) in patients with malabsorption syndrome.
Serum pancreatic secretory trypsin inhibitor (PSTI) was measured by radioimmunoassay in 5 patients with malabsorption syndrome. The serum level of PSTI was elevated to 123.8 +/- 25.8 ng/ml (Mean +/- SE) in patients with malabsorption syndrome, which was significantly higher than the 16.6 +/- 0.7 ng/ml level seen in 116 healthy control subjects. Serum PSTI levels in 5 patients with malabsorption syndrome showed inverse correlations with serum levels of cholesterol, cholinesterase and amylase, and not with serum levels of vitamin E, carotene, apoprotein A-IV, albumin, nor with immunoreactive elastase 1, respectively. These results suggest that elevated levels of serum PSTI represent a state of malnutrition due to impaired intestinal absorption.
D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000097:blood* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000378:metabolism; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood*; D014361:Trypsin Inhibitors / Q000097:blood*
D012709:Serum Albumin; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic; D002784:Cholesterol; D002802:Cholinesterases; D000681:Amylases