A large conductance, voltage- and calcium-activated K+ channel in the basolateral membrane of rat enterocytes.
The patch-clamp technique was employed to record single channel currents in patches of basolateral membrane from enterocytes isolated from rat small intestine. We demonstrate the presence of a large conductance (250 pS), voltage- and calcium-activated, the maxi, K+ channel in this membrane. Currents in this K+ channel were blocked by the application of barium (5 mM) to the extracellular membrane face.
D000818:Animals; D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity; D007421:Intestine, Small / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007473:Ion Channels; D001464:Barium; D011188:Potassium; D002118:Calcium