Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex.
Intracortical infusion of the "N-methyl-D-aspartate" (NMDA) receptor blocker D,L-2-amino-5-phosphonovaleric acid (APV) renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, 1 week of continuous APV treatment (50 nanomoles per hour) produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity-dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through ion channels linked to NMDA receptors.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002415:Cats; D003342:Corpus Striatum / Q000254:growth & development / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000502:physiology; D013569:Synapses / Q000502:physiology; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology; D014785:Vision, Ocular / Q000187:drug effects / Q000502:physiology*
D007473:Ion Channels; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D002118:Calcium