Catalysis by a prebiotic nucleotide analog of histidine.
A ribosylated derivative of adenine, N6 ribosyl adenine, likely to have formed under prebiotic synthesis conditions, is shown to be as active as histidine in the model reaction of p-nitrophenyl acetate hydrolysis. This property widens the range of reactions accessible to RNA catalysis.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D002384:Catalysis; D006639:Histidine / Q000378:metabolism*; D006868:Hydrolysis; D009596:Nitrophenols / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D009596:Nitrophenols; C054123:N(6)-ribosyladenine; D006639:Histidine; D012313:RNA; C008642:4-nitrophenyl acetate; D000241:Adenosine