title: Recombinant human TNF alpha stimulates production of granulocyte colony-stimulating factor.
abstract: Tumor necrosis factor alpha (TNF alpha) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF beta is at least 1,000-fold less potent than TNF alpha in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF alpha to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006023:Glycoproteins / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007377:Interleukin-3 / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha
chemical_list: D003115:Colony-Stimulating Factors; D006023:Glycoproteins; D007375:Interleukin-1; D007377:Interleukin-3; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor