ATP-sensitive K+ channels in human isolated pancreatic B-cells.
Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K+ channel may also have a central role in glucose-stimulated insulin secretion and may be (linked to) the receptor for the hypoglycemic sulphonylureas.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007473:Ion Channels / Q000187:drug effects*; D007515:Islets of Langerhans / Q000378:metabolism*; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D007473:Ion Channels; D000255:Adenosine Triphosphate; D014044:Tolbutamide; D005947:Glucose