Complex lipids as common antigens to Trypanosoma cruzi, T. dionisii, T. vespertilionis and nervous tissue (astrocytes, neurons).
In a dot immunobinding test glycolipid and phospholipid antigens were recognized by anti-T. dionisii (DION) and anti-T. vespertilionis (VESP) monoclonal antibodies (mabs). Five of them crossreact with T. cruzi and cells of the central nervous system (CNS) (astrocytes, neurons). Indirect immunofluorescence (IIF) of neuraminidase treated T. cruzi cells indicated that two antigens were organized in a cryptic form.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D001253:Astrocytes / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006017:Glycolipids / Q000276:immunology; D007118:Immunoassay; D008055:Lipids / Q000276:immunology*; D009439:Neuraminidase; D009474:Neurons / Q000276:immunology*; D010743:Phospholipids / Q000276:immunology; D014345:Trypanosoma / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000939:Epitopes; D006017:Glycolipids; D008055:Lipids; D010743:Phospholipids; D009439:Neuraminidase