Does basophil releasability contribute to bronchial hyperreactivity in asthma?
Histamine inhalation test and basophil degranulation test in polymxin B were performed in 21 atopic asthmatic patients. Basophil degranulation in vitro was observed in 11 patients. Positive results of the degranulation test occurred with simular frequency in patients with high and low PC20. No significant correlation between PC20 and the magnitude of degranulation was found (r = 0.09).
D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D001491:Basophils / Q000187:drug effects / Q000378:metabolism*; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D011112:Polymyxin B / Q000494:pharmacology
D011112:Polymyxin B