[Leukocyte migration test following stimulation with protein factor of neutrophilic granulocytes (PMNL) in the peripheral blood of patients with psoriasis].
Blood investigations were performed in 43 patients suffering from generalized psoriasis vulgaris and 40 healthy test persons. The results were statistically evaluated with the help of the computer technique. In the patients with active psoriasis, we found stimulation of the leucocyte migration caused by the autogenic protein factor from the peripheral blood PMNL. In addition, we observed that a mechanism like this may occur in vivo under the influence of biological degranulation factors (bacterial antigens from intraorganic infection foci). The mechanism described ist likely to act in an autoimmunostimulating way on immunologic reactions and is one of the elements which stimulate the PMNL activity in psoriatics. These results support our opinion that psoriasis is a systemic disease and indicate the role of the PMNL protein factor regarding the development of the psoriatic reaction.
D000293:Adolescent; D000328:Adult; D002464:Cell Migration Inhibition; D003115:Colony-Stimulating Factors / Q000008:administration & dosage*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D011565:Psoriasis / Q000276:immunology*
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor
Leukozytenmigrationstest nach Stimulation mit Proteinfaktor aus neutrophilen Granulozyten (PMNL) des peripheren Blutes bei Psoriasiskranken.