Maternal transmission of idiotypic network interactions selecting available T cell repertoires.
Up to 75% of 2,4,6-Trinitrophenyl (TNP)-self-specific helper T cells from normal BALB/c mice share a clonotypic determinant with the anti-TNP myeloma protein MOPC 460, recognized by the monoclonal antibody F6(51). Immunization of adult BALB/c mice with the MOPC 460 idiotype (Ab2 mice) leads to high titers of circulating anti-idiotypic antibodies but has no influence on the expression of the T cell clonotype. In contrast, TNP-self-specific helper cells prepared in progenies from Ab2 females, or in BALB/c mice treated as neonatals with anti-idiotypic antibodies, fail to express the corresponding T cell clonotype when immunized as adults. These results demonstrate the idiotype-dependent selection of T cell repertoires early in life and their stability in adults.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D009194:Myeloma Proteins / Q000276:immunology; D011247:Pregnancy; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins