title: The effect of cortisol on the plastic synapses in the developing mouse brain.
abstract: We studied the effect of cortisol on the plastic synapses in the hippocampal region of the developing mouse brain. Ethanolic phosphotungustic acid-stained synaptic junctions were reduced in the cortisol-treated mouse brain dose-dependently and irreversibly. The steroid therapy in infancy requires circumspection.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009473:Neuronal Plasticity / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D013194:Staining and Labeling; D013569:Synapses / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D006854:Hydrocortisone