title: Human immunodeficiency virus replication in human brain cells. Brief report.
abstract: Human immunodeficiency virus (HIV), the etiologic agent of AIDS, was found to infect and replicate in human brain cells. The extent of HIV replication was minimal in human brain-derived cells in comparison to T4 lymphoid cells. These results suggest that direct infection of glial/neuronal cells by HIV may contribute to the CNS dysfunction frequently observed in HIV infected individuals.
mesh_terms: D001921:Brain / Q000382:microbiology*; D002478:Cells, Cultured; D006678:HIV / Q000254:growth & development*; D006801:Humans; D066298:In Vitro Techniques; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013997:Time Factors; D014162:Transfection; D014779:Virus Replication
chemical_list: D012194:RNA-Directed DNA Polymerase