[Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia].
It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014111:Tourniquets / Q000009:adverse effects; D014115:Toxemia / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology
D007611:Aprotinin; D010447:Peptide Hydrolases
Vliianie kontrikala na dinamiku pokazateleĭ sistemy proteoliza pri postishemicheskoĭ toksemii.