title: [Endocrine changes following progesterone substitution in early pregnancy].
abstract: 250 mg hydroxy-progesteronecaproate was used for intramuscular administration in 25 patients, between 11 and 15 week's gestation, presenting either with a history of recurrent abortion or being admitted because of threatened abortion. Beta-HCG and progesterone concentrations were determined twice at intervals of 24 hours. Three women aborted without showing any increase in Beta-HCG levels nore in progesterone levels. In 20 patients Beta-HCG concentrations increased significantly after the medication, whereas only 5 patients showed a rise in progesterone levels. In 14 patients serum progesterone concentrations decreased making the use of progestational steroids in the management of threatened abortion questionable.
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000026:Abortion, Habitual / Q000097:blood / Q000517:prevention & control*; D000033:Abortion, Threatened / Q000097:blood / Q000517:prevention & control*; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006908:Hydroxyprogesterones; D010446:Peptide Fragments; D000077713:17 alpha-Hydroxyprogesterone Caproate; D011374:Progesterone
vernacular_title: Endokrine Veränderungen nach Progesteron-Substitution in der Frühschwangerschaft.