title: Synthesis of placental proteins by the human placenta perfused in vitro. Preliminary report.
abstract: Fresh human placental tissue from deliveries at term was perfused in closed circulation on both the maternal and fetal side. At given times during the 4-hour perfusion period, the amount of human chorionic gonadotropin, human placental lactogen, pregnancy-specific beta 1-glycoprotein and pregnancy-associated plasma protein A was determined in the perfusing buffer. These placental proteins were also quantified in the placental tissue before and after perfusion. Calculations showed that all placentae (n = 3) were able to synthesize all 4 proteins tested.
mesh_terms: D006063:Chorionic Gonadotropin / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D010926:Placental Hormones / Q000096:biosynthesis*; D010928:Placental Lactogen / Q000096:biosynthesis; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000096:biosynthesis; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000096:biosynthesis
chemical_list: D006063:Chorionic Gonadotropin; D010926:Placental Hormones; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen; D011266:Pregnancy-Associated Plasma Protein-A