[Antigenic specificity of the neuraminidases of epidemic strains of influenza A/H3N2 viruses circulating in the USSR 1983-1985].
The antigenic properties of neuraminidase of the epidemic strains of 1983-1985 were studied by means of lectin test and thiobarbituric method using polyclonal sera and monoclonal antibody. Populations of the viruses with respect to antigenic relationships of neuraminidase were shown to be heterogeneous. A considerable portion of the strains occurring in 1985 underwent antigenic drift from the reference A/Philippines/2/82 strain. The epidemic novelty of some strains was due to changes in only one supercapsid protein-neuraminidase.
D000911:Antibodies, Monoclonal / Q000032:analysis; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000032:analysis*; D004196:Disease Outbreaks; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007158:Immunologic Techniques; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000201:enzymology / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000382:microbiology; D009439:Neuraminidase / Q000276:immunology*; D014586:USSR
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D009439:Neuraminidase
Antigennaia spetsifichnost' neĭraminidaz épidemicheskikh shtammov virusov grippa A/H3N2, tsirkulirovavshikh v SSSR v 1983-1985 gg.