DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.
We have previously described two synthetic models gathering a simplified model of the complexing part of Bleomycin (Blm) and the intercalating moiety of m-AMSA. These molecules, namely AGGA and AGAMGA, do not seem able to cleave DNA as Blm does. The present work is devoted to the study of a new derivative, AGAGLU, which includes in its structure a judiciously chosen connector between the two parts of the molecule. This compound, the chelating and DNA-binding properties of which are described here, has been shown to induce single-strand breakage of duplex DNA in a high level.
D000609:Aminoacridines / Q000138:chemical synthesis / Q000494:pharmacology*; D000677:Amsacrine / Q000494:pharmacology*; D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002417:Cattle; D002614:Chelating Agents / Q000494:pharmacology; D002942:Circular Dichroism; D003300:Copper; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013950:Thymus Gland
D000609:Aminoacridines; D002614:Chelating Agents; D004268:DNA-Binding Proteins; D005609:Free Radicals; D000677:Amsacrine; D001761:Bleomycin; C055725:(((amino-2-ethyl)-2-aminomethyl)-2-pyridine-6-carboxylhistidyl-gamma-(2-amino-2-deoxyglucosyl)glutamylglycylamino)-4-phenyl-1-aminoacridine; D003300:Copper; D005944:Glucosamine