title: Kainic acid-induced terminal degeneration in the dorsal lateral geniculate of tree shrew.
abstract: The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of the geniculate nucleus. The actions of kainic acid upon both the presynaptic terminals and geniculate neurons may be mediated by a glutamatergic pathway and questions the hypothesis that kainic acid is solely neuron-specific in its toxic action.
mesh_terms: D000818:Animals; D005829:Geniculate Bodies / Q000187:drug effects* / Q000473:pathology; D006735:Horseradish Peroxidase; D007608:Kainic Acid / Q000633:toxicity*; D009410:Nerve Degeneration / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000378:metabolism; D014418:Tupaiidae / Q000502:physiology*; D014795:Visual Pathways / Q000187:drug effects / Q000473:pathology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D007608:Kainic Acid