[Comparative study of the properties of preparations of native and modified collagenase].
Collagenase was gradually modified by aldehyde dextran and hyaluronidase. The modification increased enzyme stability and widened pH-optimum of its activity against specific and biological substrates. The modified complex with collagenolytic and hyaluronidase activity accumulated in the lungs of mice after intravenous injection. These results demonstrate its possible use for the treatment of lung disorders.
D000447:Aldehydes / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D002384:Catalysis; D003911:Dextrans / Q000493:pharmacokinetics / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000493:pharmacokinetics / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D003012:Microbial Collagenase / Q000493:pharmacokinetics / Q000494:pharmacology*; D008970:Molecular Weight; D013997:Time Factors; D014018:Tissue Distribution
D000447:Aldehydes; D003911:Dextrans; D006821:Hyaluronoglucosaminidase; D003012:Microbial Collagenase
Sravnitel'noe izuchenie svoĭstv preparatov nativnoĭ i modifitsirovannoĭ kollagenazy.