Roles of opioid peptides of PAG in analogous electro-acupuncture inhibition of experimental arrhythmia: analyzed by specific antisera microinjection.
Using specific antisera microinjected into periaqueductal grey (PAG), we further studied the mechanism of the analogous electroacupuncture, deep peroneal nerve stimulation (DPNS), inhibition on the experimental arrhythmia, hypothalamic stimulation-induced ventricular extrasystoles (HVE). Neither normal serum nor anti-leu-enkephalin antiserum interfered with DPNS inhibition; anti-dynorphin A (1-8) tended to attenuate the inhibition; and anti-beta-endorphin antiserum blocked it. The results provided further evidence for the hypothesis that beta-endorphin in PAG plays an important role in the neural circuit of DPNS inhibition on HVE.
D015670:Acupuncture Therapy; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D004558:Electric Stimulation; D004723:Endorphins / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D010487:Periaqueductal Gray / Q000187:drug effects / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000187:drug effects / Q000502:physiology; D011817:Rabbits
D004723:Endorphins; D007106:Immune Sera