Report of the 1985 ISSLS Traveling Fellowship. Mechanisms of spinal pain. The dorsal root ganglion and its role as a mediator of low-back pain.
The dorsal root ganglion as a mediator for low-back pain in an animal model was investigated. Low-frequency vibration, a known mechanical cause of low-back pain, was investigated. Quantitative results suggest a significant reduction effect on substance P, one of several neurotransmitters located in the dorsal root ganglion. The functional results of these changes are currently under investigation.
D000818:Animals; D001416:Back Pain / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism / Q000503:physiopathology*; D011817:Rabbits; D013373:Substance P / Q000378:metabolism* / Q000502:physiology; D014732:Vibration
D013373:Substance P