Mitogenic responses of splenic B and T lymphocytes in neonatally capsaicin-treated mice.
The proliferative response of spleen cells from neonatally capsaicin-treated mice to 5 mitogens (LPS, PWM, dextran sulfate, ConA and PHA) were tested. Both B- and T-lymphocyte responses were essentially unaffected by the capsaicin treatment, which is known to destroy certain small-sized neuropeptide containing primary sensory neurons. However, the capsaicin-treated mice displayed a shift in the dose response to PHA so that the maximal response was obtained with a lower dose of the mitogen. The results exclude major effects of the affected sensory neurons on the development or expression of immune competence, but point to a possible modulatory effect on some step in the response to PHA.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001835:Body Weight / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013154:Spleen / Q000276:immunology* / Q000294:innervation; D013601:T-Lymphocytes / Q000276:immunology*
D003911:Dextrans; D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D016264:Dextran Sulfate; D002211:Capsaicin