title: Protective effect of iloprost and UK 38 485 against gastric mucosal damage induced by various stimuli.
abstract: This study was undertaken to evaluate the efficacy of iloprost and UK 38485 in the prevention of gastric lesions due to restraint-cold stress, ethanol or indomethacin. Prior injection of iloprost to the rats significantly prevented the increase in ulcer index by restraint- cold stress or indomethacin but nonsignificantly reduced the ulcer index induced by ethanol. UK 38 485 at lower doses caused a highly significant decrease in the ulcer index induced by all noxious stimuli used in this study. UK 38 485 also reduced the increased 3H back diffusion due to restraint-cold stress. Higher doses of the compound, however, failed to decrease the mucosal damage due to restraint-cold stress. Combination of iloprost and UK 38 485 produced a further significant decrease in the ulcer index induced by all noxious stimuli and increased 3H back diffusion induced by restraint-cold stress. In relation to these results the importance of PGI2/TXA2 ratio in the production of gastric mucosal lesions is discussed.
mesh_terms: D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D016285:Iloprost; D007093:Imidazoles / Q000494:pharmacology*; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control; D013312:Stress, Physiological / Q000473:pathology; D013928:Thromboxane A2 / Q000032:analysis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
chemical_list: D007093:Imidazoles; C039242:dazmegrel; D000431:Ethanol; D013928:Thromboxane A2; D011464:Epoprostenol; D013930:Thromboxane-A Synthase; D016285:Iloprost; D007213:Indomethacin