Reaction of monoclonal anti Leu M1--a myelomonocytic marker (CD15)--with normal and neoplastic epithelia.
The present study describes the distribution of Leu M1 (CD15) immunoreactivity in 13 normal epithelia and 14 epithelial neoplasms. The findings are compared with those obtained using other epithelial markers. Cautionary points and broad recommendations are made with regard to use of anti Leu M1 antibody.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D018396:Mucin-1; D009369:Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D008565:Membrane Proteins; D018396:Mucin-1; D007633:Keratins