title: Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.
abstract: Hypertensive action was observed in conscious rats injected intraventricularly with glandular kallikrein (EC 3.4.21.35) in a dose-dependent manner (4-16 KU), which was associated with the enhancement of brain kinin level. Concurrently administered aprotinin, a kallikrein inhibitor, led to an inhibition of these effects of kallikrein. These results suggest that the central hypertensive action of kallikrein is mediated via the kinin liberated from a kininogen in the brain.
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D007276:Injections, Intraventricular; D007610:Kallikreins / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
chemical_list: D007705:Kinins; D007611:Aprotinin; D007610:Kallikreins