[The DM-20 proteolipid is a major protein of the brain. It is synthetized in the fetus earlier than the major myelin proteolipid (PLP)].
By studying highly purified CNS proteolipids, we have shown that DM-20 proteolipid, which was considered, until now, to be a minor brain proteolipid is, in fact, almost as abundant as the Major Myelin Proteolipid known also as Proteolipid Protein (PLP). DM-20 proteolipid is even the major brain proteolipid in young foetuses. It is only during myelinisation that the "Proteolipid Protein" increases rapidly and becomes equivalent in weight to DM-20 proteolipid. This study raises the question of the particular function of DM-20 proteolipid.
D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D001923:Brain Chemistry; D002417:Cattle; D009185:Myelin Proteins / Q000032:analysis / Q000096:biosynthesis*; D018991:Myelin Proteolipid Protein; D009419:Nerve Tissue Proteins; D011510:Proteolipids / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats
D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D009419:Nerve Tissue Proteins; C489071:Plp1 protein, rat; D011510:Proteolipids
Le protéolipide DM-20 est une protéine majeure du cerveau. Il est synthétisé dans le foetus avant le protéolide majeur de la myéline (PLP).