[Particles with retrovirus appearance and reverse transcriptase activity in cell cultures derived from lymph node biopsies in Hodgkin's disease].
Long term cultures of Reed-Sternberg like cells were obtained from lymph node biopsies of two patients suffering from Hodgkin's disease. As soon as the 15th day of culture, a weak magnesium-dependent reverse transcriptase activity was observed in the cell culture supernatants. Retroviral-like particles were observed in cell cultures as well as in their supernatants.
D000328:Adult; D001706:Biopsy; D002478:Cells, Cultured; D005260:Female; D006689:Hodgkin Disease / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology* / Q000473:pathology; D008297:Male; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D012190:Retroviridae / Q000201:enzymology / Q000302:isolation & purification*
D012194:RNA-Directed DNA Polymerase
Particules d'aspect rétroviral et activité transcriptase inverse dans des cultures cellulaires dérivées de biopsies ganglionnaires de malade de Hodgkin.