[Enzymes involved in the metabolism, replication and repair of DNA in acute leukemias (DNA ligases)].
DNA ligases are involved in DNA replication, repair and recombination. Consecutively to partial purification, these enzymes have been studied in acute leukemias and subclasses. There is a good correlation between this enzyme activity and the percentage of cells in S phase in acute myeloblastic leukemia. However, in acute lymphoblastic leukemia, a low and even absent activity (T-ALL) is observed. It is shown that in this type of leukemia, the absence of activity is due to either the absence or the non expression of the DNA ligase gene. The results are discussed in terms of the correlation between the absence of ligase activity and the expression of the TdT phenotype.
D004247:DNA / Q000378:metabolism*; D011088:DNA Ligases / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D007399:Interphase; D007945:Leukemia, Lymphoid / Q000201:enzymology* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology* / Q000473:pathology; D011118:Polynucleotide Ligases / Q000378:metabolism*; D012313:RNA / Q000032:analysis / Q000235:genetics
D012313:RNA; D004247:DNA; D011088:DNA Ligases; D011118:Polynucleotide Ligases
Enzymes impliquées dans le métabolisme, la replication et la réparation du DNA dans les leucémies aiguës (DNA ligases).