The glucocorticosteroid, budesonide, partially blocks histamine release from human lung tissue in vitro.
IgE-receptor dependent, but not A23187-induced, histamine release from passively sensitized chopped human lung tissue, or from a dispersed lung cell population obtained from the tissue after enzymatic digestion, is reduced after incubation overnight of cells/tissue with the glucocorticosteroid budesonide (10(-7) M). Since the inhibitory effect of budesonide is reduced in the continuous presence of diluted reagin-rich serum used for passive sensitization, but not in the presence of heat-inactivated serum, it is suggested that the glucocorticosteroid acts by reducing the binding of IgE-antibody to the target cell(s).
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D019819:Budesonide; D000001:Calcimycin / Q000494:pharmacology; D002478:Cells, Cultured; D005938:Glucocorticoids / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D011058:Pollen / Q000276:immunology; D011282:Pregnenediones / Q000494:pharmacology*; D011935:Reagins / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D005938:Glucocorticoids; D011282:Pregnenediones; D011935:Reagins; C026408:anti-IgE antibodies; D007073:Immunoglobulin E; D000001:Calcimycin; D019819:Budesonide