title: Improvements in instrumentation for thermospray operation on a magnetic sector mass spectrometer.
abstract: Changes in the design of a thermospray liquid chromatography-mass spectrometry ion source can be made to improve the sensitivity towards solute related ions and therefore extend the practical utility of the complete system. The addition of a discharge ionization facility provides much greater scope for gradient elution analyses and forms the basis of a method which offers increased structural information. All of these changes are illustrated by practical examples.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004917:Erythromycin / Q000032:analysis; D006096:Gramicidin / Q000032:analysis; D013058:Mass Spectrometry; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000032:analysis*
chemical_list: D006096:Gramicidin; D011092:Polyethylene Glycols; D004917:Erythromycin