title: Antibiotic levels in bovine lacrimal fluid after single application of ointments containing procaine benzyl penicillin plus dihydrostreptomycin; and benzathine cloxacillin.
abstract: The efficacy of an experimental slow-release formulation, containing procaine benzyl penicillin and dihydrostreptomycin, was investigated in a cross-over study with a cloxacillin eye ointment in 12 cows with clinically normal eyes. After a single topical application the therapeutic concentrations of penicillin were sustained for 48 to 92 hours and of cloxacillin for 32 to 48 hours. These long-acting ointments will simplify the successful treatment of painful eye disorders such as keratoconjunctivitis. A practical and non-irritant method for sampling tears is described.
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D003023:Cloxacillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004338:Drug Combinations; D005260:Female; D009824:Ointments; D009883:Ophthalmic Solutions; D010400:Penicillin G / Q000493:pharmacokinetics*; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012016:Reference Values; D013666:Tears / Q000378:metabolism*
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D009824:Ointments; D009883:Ophthalmic Solutions; D010402:Penicillin G Procaine; C006692:benzathine cloxacillin; D003023:Cloxacillin; D010400:Penicillin G; D004096:Dihydrostreptomycin Sulfate