Post-irradiation leiomyosarcoma. Case report with immunohistochemical studies.
We report here one case of post-irradiation leiomyosarcoma. The diagnosis of this was confirmed using anti-intermediate filament antibodies: tumor cells were positive for anti-vimentin and anti-desmin but negative for anti-prekeratin and anti-epithelial membrane antigen. The positive staining with anti-desmin clearly indicates a muscular origin although the tumor cells were not stained by two anti-actin antibodies, one directed against alpha-smooth muscle actin and the other against alpha-striated muscle actin. Irradiation was motivated by a wrong diagnosis of breast carcinoma when the patient was 13 year-old. The laps of time separating irradiation and the occurrence of the leiomyosarcoma was 13 years. The total dose was 6,000 rads. This is the ninth case of post-irradiation leiomyosarcomas reported in the literature.
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000328:Adult; D000911:Antibodies, Monoclonal; D003893:Desmin / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D007633:Keratins / Q000378:metabolism; D007890:Leiomyosarcoma / Q000209:etiology / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000032:analysis; D018396:Mucin-1; D009130:Muscle, Smooth / Q000648:ultrastructure; D009381:Neoplasms, Radiation-Induced / Q000648:ultrastructure*; D011878:Radiotherapy / Q000009:adverse effects; D014746:Vimentin / Q000378:metabolism
D000911:Antibodies, Monoclonal; D003893:Desmin; D008565:Membrane Proteins; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins