title: Action of 3-methylquercetin on poliovirus RNA replication.
abstract: 3-Methylquercetin is a natural flavone that powerfully blocks poliovirus replication. This compound inhibits selectively poliovirus RNA synthesis both in infected cells and in cell-free systems. Poliovirus double-stranded RNA (replicative forms) is still made in the presence of this inhibitor, whereas the synthesis of single-stranded RNA and the formation of replicative intermediates are drastically blocked.
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D005814:Genes, Viral; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D017955:Poliovirus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects; D012330:RNA, Double-Stranded / Q000096:biosynthesis / Q000187:drug effects; D012367:RNA, Viral / Q000096:biosynthesis* / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D044948:Flavonols; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C047368:3-methylquercetin; D012313:RNA; D011794:Quercetin