The effect of fibrin tissue adhesive on the middle and inner ears of chinchillas.
The purpose of this study was to examine potential toxic effects of fibrin tissue adhesive to the middle and inner ears. Using the chinchilla as our experimental model, we placed fibrin sealant on either the footplate or the round window membrane in one ear, and placed similar amounts of normal saline in the same area of the opposite ear. In addition, the fibrin adhesive was used to anchor a fascia lata graft for myringoplasty. Both fibrin adhesive and normal saline produced mild reactions in the middle and inner ears when they were placed on the round window membrane; little reaction occurred when fibrin adhesive was placed on the oval window or when it was used for myringoplasty.
D000818:Animals; D007611:Aprotinin / Q000009:adverse effects*; D002682:Chinchilla; D003487:Cyanoacrylates / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D007758:Ear, Inner / Q000187:drug effects*; D004432:Ear, Middle / Q000187:drug effects*; D005176:Factor XIII / Q000009:adverse effects*; D005206:Fascia Lata / Q000637:transplantation; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000009:adverse effects*; D009225:Myringoplasty; D010046:Oval Window, Ear / Q000187:drug effects; D012405:Round Window, Ear / Q000187:drug effects; D013917:Thrombin / Q000009:adverse effects*; D014014:Tissue Adhesives / Q000009:adverse effects*
D003487:Cyanoacrylates; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin; C008424:methyl 2-cyanoacrylate