Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin.
Histamine release was directly measured in in vivo skin blisters in rats in response to the intradermal injection of the peptide neurotensin (NT). Histamine release increased as the concentration of NT was raised from 10(-11) to 10(-5) M. This response was rapid in onset and was inhibited by disodium cromoglycate or the peptide somatostatin (SIRF). The inhibitory effect of SIRF was rapid and was evident from 10(-12) to 10(-8) M SIRF. A similar inhibition was observed on isolated peritoneal mast cells. Histamine release in response to substance P was not inhibited by SIRF.
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology; D003864:Depression, Chemical; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology
D013189:SRS-A; D009496:Neurotensin; D013004:Somatostatin; D004205:Cromolyn Sodium