title: Nasopharyngeal carcinoma: a review of cases treated by radiotherapy and chemotherapy.
abstract: Between 1965 and 1983, 52 cases of carcinoma of the nasopharynx were treated with radiotherapy alone and 14 treated with combination chemotherapy containing cisplatin followed by a radical course of radiation. Before 1981 all cases were treated by radiotherapy alone with a variety of dose and fractionation regimes. The actuarial overall 3 year survival for these cases was 35%. Twelve of the 14 (86%) who received chemotherapy responded, and in two there was complete disappearance of disease before the radiotherapy. The 3 year survival for those receiving chemotherapy and radiotherapy was 86%. The possible reasons for this apparent improvement are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil