Comparison of the release of various mediators from atrial and ventricular tissues of sensitized guinea-pig hearts.
By comparison with ventricular tissues, collagenase-dispersed cell suspensions obtained from atrial tissues of sensitized guinea-pigs showed a higher histamine content, a higher proportion of mast cells, and a higher release with antigen or antisera to IgG, IgG1 and IgG2 of the following mediators: histamine, thromboxane B2 and leukotriene C4.
D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism* / Q000473:pathology; D006168:Guinea Pigs; D006325:Heart Atria; D006352:Heart Ventricles; D006636:Histamine Release; D006967:Hypersensitivity / Q000378:metabolism* / Q000473:pathology; D008407:Mast Cells / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D013189:SRS-A / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*
D013189:SRS-A; D013929:Thromboxane B2