[Effect of substance P on gastric secretion and serum gastrin levels].
I. m. administration of substance P (5, 10, 15 and 20 micrograms/kg) insignificantly increased gastric secretion induced with histamine. I. v. administration of substance P (2 and 5 micrograms/kg/hr) considerably potentiated gastric secretion induced with histamine. Microapplication of substance P to the hypothalamus (10 micrograms in 3 microliters of saline) also led to a considerable increase of the gastric secretory response, whereas the same microapplication to the amygdala decreased gastric secretion induced with histamine. Microapplication of substance P and an alpha-adrenoblocking agent to these cerebral structures augmented the response of the stomach secretory cells. The level of the serum gastrin decreased following i. v. administration of substance P to hungry dogs.
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006632:Histamine / Q000008:administration & dosage; D007031:Hypothalamus / Q000187:drug effects; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010643:Phenoxybenzamine / Q000008:administration & dosage; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D005755:Gastrins; D010643:Phenoxybenzamine; D013373:Substance P; D006632:Histamine
Vliianie substantsii P na zheludochnuiu sekretsiiu i na kontsentratsiiu gastrina syvorotki krovi.