Animal experiments on hemostasis with a collagen-fibrin tissue-adhesive sealant in the nephrostomy tract.
After a median laparatomy, nephrostomy was performed on 22 porcine kidneys: puncture, dilatation and introduction of a 26-French operating sheath through the parenchyma into the renal pelvis. At the end of the operation, an 8-French nephrostomy catheter prepared with a collagen-fibrin tissue-adhesive sealant was introduced through the operating sheath and the sheath was afterwards extracted. The hemostasis in the nephrostomy tract was very good in all 22 cases. There were no complications such as wound infection or stone formation during a post-operative period of between one and 95 days. Experimental investigations showed severe bleeding in nontamponade of the nephrostomy tract, in tamponade with an 8-French nephrostomy catheter and in tamponade of the nephrostomy tract with the collagen fleece wrapped around an 8-French nephrostomy catheter but not coated with the fibrin glue.
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D006488:Hemostasis, Surgical; D009403:Nephrostomy, Percutaneous; D013552:Swine; D013556:Swine, Miniature; D013917:Thrombin / Q000008:administration & dosage*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D003094:Collagen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin