[Elimination of saccharose from the blood and its renal excretion following transfusion of buffy coat-free erythrocyte concentrates containing disaccharides].
The elimination of sucrose from the blood and its renal excretion was analysed in 108 patients after applying a total of 394 transfusion units (TE), resuspended, buffy-coat-free erythrocyte concentrates (EK) containing 23 mmol of sucrose per TE. In transfusing 3 TE even 90% of the sucrose were eliminated from the blood during the application time and up to 99% within 3 h, nearly 80% were excreted through the kidneys within 12 h. Elimination and excretion were delayed with impaired kidney function. With respect to intravasal elimination of sucrose bilaterally nephrectomized patients have to rely on hemodialysis. Side-effects of sucrose due to extended intravasal and interstitial duration could not be observed in those patients affected with decreased kidney efficiency and after massive transfusions.
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000628:therapy*; D001793:Blood Preservation; D001803:Blood Transfusion; D004187:Disaccharides / Q000008:administration & dosage*; D017707:Erythrocyte Transfusion; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D013395:Sucrose / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004187:Disaccharides; D013395:Sucrose; D005947:Glucose
Zur Eliminierung von Saccharose aus dem Blut und ihrer renalen Ausscheidung nach Transfusion buffy coat-freier, disaccharidhaltiger Erythrozytenkonzentrate.