title: Effect of acetylcholine and dopamine iontophoretically applied on the sensory responsive caudate unit.
abstract: A putative integrative function of the striatum was evaluated through the study of the electrical activity of sensory responsive caudate neurones. Both nervous (radial nerve) and auditory stimulations were delivered in order to characterize populations of neurones affected by peripheral stimuli; the units were previously activated by iontophoretic glutamate. On these units the iontophoretic ejection of ACh and DA was tested. Experimental results demonstrated a prevalent excitatory effect of ACh, while DA appeared to exert a drastic decrease on firing rate. A comparison between peripheral stimuli and chemical substances was made. The result of such study showed a most important action of the neurotransmitters employed. The activity of caudate units following single shock activation was also explored. This investigation underlined a certain degree of facilitatory influence of ACh; DA, on the contrary, had the tendency to exert a marked inhibitory action. The results are interpreted in view of the striatal peculiar position on cortico-striato-thalamo-cortical circuit. An integrative function of basal ganglia on sensori-motor activity of the cortex is postulated and the importance of ACh and DA is emphasized.
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000161:Acoustic Stimulation; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000166:cytology / Q000187:drug effects*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004558:Electric Stimulation; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects
chemical_list: D000109:Acetylcholine; D004298:Dopamine