Effect of single dichloromethane administration on the adrenal medulla of male albino rats.
Adult male albino rats received a single dose of dichloromethane (DCM) orally. In response to administrations of DCM, 6.2 or 9.4 mmol/kg body mass, urinary catecholamine excretion increased significantly. 4 h and 48 h following a single DCM dose of 15.6 mmol/kg body mass, morphological investigations revealed cytological changes and a distinct reduction of chromaffin reaction in the adrenal medulla. The norepinephrine contents of cells were decreased strongly 4 h after DCM administration and increased weakly again, but distinct reduced in comparison with the control animals 48 h later. The mean nuclear volumes in the norepinephrine and epinephrine cells were enhanced significantly 4 h as well as 48 h after acute DCM intoxication.
D000284:Administration, Oral; D000313:Adrenal Medulla / Q000187:drug effects*; D000818:Animals; D002395:Catecholamines / Q000652:urine; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D008752:Methylene Chloride / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013194:Staining and Labeling
D002395:Catecholamines; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride