[Nucleic acids of the lymphoid cells of the pregnant rat subjected to space flight and its progeny].
The space flight effect on the synthesis of nucleic acids in spleen lymphocytes in pregnant rats and their offspring was investigated. In addition to the inhibition of the DNA replicative function previously detected in males, activation of RNA synthesis was seen in the pregnant females. Such changes did not develop in the synchronous mockup controls. The 30-day and 100-day old pups of the rats flown in space during the last third of their pregnancy showed no changes in the DNA replicative function. The 100-day old animals displayed only a slight, when compared to the vivarium controls, decline of RNA synthesis which was produced by concomitant factors rather than by microgravity per se. It is supposed that microgravity-induced activation of RNA synthesis in spleen lymphocytes of pregnant rats is associated with the involvement of these cells in adaptive trophic processes that are to maintain plastic homeostasis of the fetus in an unusual environment.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism*; D011270:Pregnancy, Animal / Q000378:metabolism*; D011297:Prenatal Exposure Delayed Effects; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013154:Spleen / Q000378:metabolism*
D012313:RNA; D004247:DNA
Nukleinovye kisloty limfoidnykh kletok selezenki beremennykh krys, perenesshikh kosmicheskiĭ polet, i ikh potomstva.