[Prevention of damages to the microsomal monooxygenases in thermal ischemia of the liver by the separate and combined use of alpha-tocopherol, lidocaine and kontrikal].
It was found in experiments on the in vitro model of rat liver ischemia that ischemia initiates membrane lipid peroxidation and proteolysis leading to damage of monooxygenase enzyme systems of microsomes. Preventive administration of alpha-tocopherol, lidocaine, contrykal and their combinations revealed the optimal protective effect of the combined administration of alpha-tocopherol with lidocaine and alpha-tocopherol with contrykal as compared to their separate use on the functional activity of microsomal monooxygenases at thermal ischemia of the liver. A combined approach to prevention of impairment of the liver function at its ischemia was recommended.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006358:Hot Temperature / Q000009:adverse effects*; D007511:Ischemia / Q000201:enzymology / Q000517:prevention & control*; D008012:Lidocaine / Q000627:therapeutic use*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D008054:Lipid Peroxides; D014810:Vitamin E; D007611:Aprotinin; D008012:Lidocaine; D010105:Oxygenases
Profilaktika povrezhdeniĭ mikrosomal'nykh monooksigenaz pri teplovoĭ ishemii pecheni razdel'nym i kombinirovannym primeneniem al'fa-tokoferola, lidokaina i kontrikala.