title: IgE-mediated food allergy.
abstract: The behaviour of some immunologic parameters was studied in order to explain the presence or the lack of symptomatology in subjects with IgE specific to foods. In particular, we compared the levels of serum and salivary IgA and IgE antibody specific to apple in 33 patients allergic to birch and with anti-apple IgE, of whom 24 had oral allergy syndrome after eating apple and nine were apple tolerants. We found no differences in the IgE-related parameters such as levels of anti-apple IgE antibody in serum and secretions, mean size of apple skin prick test, and number of patients with a positive histamine release from peripheral basophils stimulated by apple. Similarly, we detected no statistically significant differences in serum and salivary total IgG and total anti-apple IgA antibody of the two groups. We could, however, observe a significantly higher anti-apple salivary IgA/anti-apple serum IgE and anti-apple salivary IgA/anti-apple serum IgA ratios and a significant correlation between the same parameters in tolerant patients when compared with the intolerants. These results seem to suggest that the presence of appropriate levels of secretory anti-apple IgA associated to anti-apple IgE might be one of the factors playing a key role in the prevention of clinical symptoms in atopic subjects.
mesh_terms: D005512:Food Hypersensitivity / Q000276:immunology*; D005638:Fruit / Q000009:adverse effects*; D006636:Histamine Release; D006801:Humans; D007108:Immune Tolerance; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology; D011852:Radioallergosorbent Test; D012463:Saliva / Q000276:immunology; D014197:Trees / Q000276:immunology
chemical_list: D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins; D007073:Immunoglobulin E