A protein of squamous keratinising epithelium from odontogenic keratocyst fluid.
Fluid from odontogenic keratocysts was analysed. The major protein fraction with a mobility anodal to albumin on electrophoresis was shown not to be albumin or pre-albumin but a non-serum protein. Using an antiserum to keratocyst fluid absorbed with human serum, non-serum components of the odontogenic keratocyst fluid were localised in squamous keratinising epithelia, principally in the upper layers. The same antiserum showed immuno-localisation in squamous cell carcinoma of skin and cervix. No localisation was seen in normal non-squamous epithelia, in liver, stomach and colon or in non-keratinising squamous epithelial cysts of the jaw.
D001826:Body Fluids / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D004848:Epithelium / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000096:biosynthesis*; D009055:Mouth / Q000378:metabolism*; D009807:Odontogenic Cysts / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D011506:Proteins; D007633:Keratins