[Hemodynamic studies of iloprost-conditioned ischemically stressed kidneys in animal experiments].
By means of computer-assisted Doppler signal analysis on the exposed renal artery of the pig the change of the haemodynamics under the influence of Iloprost is investigated in comparison to the electromagnetic flow measurement. The Doppler sonographic establishment of the speed of the blood flow and the relative volume of the blood flow allows additional informations about characteristic changes of the form of the pulse. During the measurement in situ on the renal artery the result was during the intraarterial application of Iloprost a distinct increase of the renal blood flow with simultaneous decrease of the renal resistance, which, issuing from the Doppler signal analysis, is characterized as change of the renal resistance index. The kidneys conditioned under influence of Iloprost were retransplanted after a warm ischaemia-time of 45 minutes with following machine preservation of 24 hours and showed a stable flow characteristics for the whole investigation period. The Doppler signals directly conducted via the renal parenchyma showed a stable pulsation also in the smaller arterial vessels.
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D016285:Iloprost; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D012079:Renal Circulation / Q000187:drug effects*; D012212:Rheology; D013552:Swine; D014664:Vasodilation / Q000187:drug effects
D002317:Cardiovascular Agents; D011464:Epoprostenol; D016285:Iloprost
Hämodynamische Untersuchungen an Iloprost-konditionierten ischämisch belasteten Nieren im Tierexperiment.