Regulatory function of cell surface molecules CD2-, LFA- and beta 2-microglobulin in natural killer cell activity.
The functional importance of various cell membrane bound molecules was studied and compared in the NK cytotoxicity and CTL activity. LFA-1 and CD2 participate in both killing functions, while CD3 and CD8/CD4 as well as MHC class I molecules are involved only in CTL activity. Nevertheless CD2- and beta 2-microglobulin are representatives of the NK function. It was demonstrated that CD2-, LFA-1 and beta 2-microglobulin molecules have an additive and complementary function in the killing mechanism. The upregulation of alpha- and gamma-interferons on NK function seems not to be a consequence of the enhanced expression of these molecules on the cell surface induced by IF at the same time.
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D001613:beta 2-Microglobulin / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1; D001613:beta 2-Microglobulin; D007372:Interferons