Repair processes of hemopoiesis after applying cyclophosphamide. I. Morphological changes in the bone marrow, spleen and thymus.
Processes of hemopoiesis repair were monitored in rats till the day 30 after applying cyclophosphamide in doses of 100 and 200 mg X kg-1. Profound decrease of the hemopoietic activity in the bone marrow, spleen, and thymus was observed till the day 3. The reported changes were reversible, since the myelopoiesis was recovered till the day 10 in the bone marrow and the erythropoiesis in the spleen till the day 20. Significantly slower progress in repair process was observed in the lymphoid tissue; here the recovery was not completed till the day 30.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors
D003520:Cyclophosphamide