Effects of bovine growth hormone in infant rats from reduced litters.
The objective of this study was to determine the effects of growth hormone on body growth and the content of RNA, DNA and protein in liver, brain and heart muscle in rat pups from reduced nests. Suckling rats raised in litters of 4 youngs were daily injected from 3rd to 28th day of life with 1 microgram of bGH/g body weight. Our results show that GH administration evoked higher body weight gain and increase of tail length after 23rd day of life. There was significant increase of liver content of nucleic acids and protein. This GH-responsivity of pups from reduced nests might be related to differences in their metabolic profile and accelerated somatic and psychosocial development in comparison to normal youngs.
D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D013006:Growth Hormone / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008098:Litter Size; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011986:Receptors, Somatotropin / Q000378:metabolism
D011506:Proteins; D011986:Receptors, Somatotropin; D012313:RNA; D013006:Growth Hormone; D004247:DNA