Influence of neural blockade and indomethacin on leucocyte, temperature, and acute-phase protein response to surgery.
Body temperature, P-cortisol, P-glucose, P-transferrin, haematocrit and total and differential leucocyte counts were investigated in 24 men undergoing inguinal herniotomy, but otherwise healthy. The patients were randomized to general anaesthesia (GA, n = 8), epidural analgesia (E, n = 8) or epidural analgesia + indomethacin (E + I, n = 8). The rectal temperature rose significantly after surgery, except in the E + I group, and increase in blood granulocytes was significantly less in these patients than in the GA group. Group E showed intermediate changes. P-transferrin changes were similar in all three groups. Glucose and cortisol showed only slight increase in the GA group and constant values in groups E and E + I. It is concluded that prostaglandins may play a role in mediating the surgical stress response, but that factors other than neural stimuli and prostaglandins are important in releasing postoperative granulocytosis.
D000209:Acute-Phase Proteins / Q000187:drug effects*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001831:Body Temperature / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects; D006400:Hematocrit; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007213:Indomethacin / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D011453:Prostaglandins / Q000096:biosynthesis*; D013312:Stress, Physiological / Q000503:physiopathology; D014168:Transferrin / Q000032:analysis
D000209:Acute-Phase Proteins; D001786:Blood Glucose; D011453:Prostaglandins; D014168:Transferrin; D006854:Hydrocortisone; D007213:Indomethacin