CSF tryptophan and transmitter amine turnover may predict social behaviour in the normal rat.
Central 5-hydroxytryptamine (5-HT) and dopamine (DA) turnovers and tryptophan concentrations were estimated in individual male rats using repeated CSF withdrawal. On subsequent pairing, the major biters of each pair (neck + body bites) were predicted by their higher concentrations of the 5-HT precursor tryptophan but not by 5-HT turnover. However, bites/pair correlated highly significantly with the lower 5-HT and DA turnover values in each pair. The investigation illustrates a new and flexible approach to the neurochemistry of social behaviour.
D000374:Aggression / Q000502:physiology; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D012919:Social Behavior; D012930:Social Dominance; D014364:Tryptophan / Q000134:cerebrospinal fluid*
D018377:Neurotransmitter Agents; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D004298:Dopamine