Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline.
Systemic blood pressure and pulse rate responses to intravenously administered adrenaline during hypoxaemia or hyperoxaemia were studied in urethane-anaesthetized rats. Hypoxaemia or hyperoxaemia was induced by ventilating the animals with 15% O2/85% N2 or with 100% O2, respectively. Hypoxaemia significantly decreased the diastolic blood pressure and elevated the pulse rate; the reflex falls in pulse rate in response to adrenaline were significantly reduced. Hyperoxaemia, on the other hand, did not cause remarkable changes in blood pressure or pulse rate, but significantly depressed diastolic blood pressure to adrenaline. It is suggested that the compensatory cardiovascular reflexes may be impaired by hypoxaemia, and that hyperoxaemia reduces vasoconstrictor response to catecholamine possibly by lessening or enhancing the sensitivities of the vascular alpha 1- or beta 2-adrenoceptors, respectively.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004837:Epinephrine / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood* / Q000633:toxicity; D011674:Pulse; D051381:Rats; D011919:Rats, Inbred Strains
D010100:Oxygen; D004837:Epinephrine