Action of intragastric ethanol on pancreatic exocrine secretion in relation to the interdigestive gastrointestinal motility in humans.
On different days, fasted volunteers were given either 100 ml of ethanol (40% v/v), glucose (isocaloric to ethanol) or distilled water intragastrically; the instillations always starting during the first observed duodenal phase I of the interdigestive migrating complex (IMC). Both ethanol and glucose produced a fed pattern of motility but only glucose significantly (P less than 0.05) delayed the reappearance of a new duodenal phase III of the IMC when compared to water. Ethanol and glucose significantly increased the 1-h duodenal bicarbonate output 7- and 16-fold, respectively. Glucose, but not ethanol, stimulated the duodenal amylase output when compared to water. Glucose, but not ethanol, caused a significant rise in plasma gastrin concentration; plasma secretin levels not being altered by both substances. We conclude that in non-alcoholic humans, an intragastric administration of ethanol in a concentration present in whisky and in an amount that is consumed in ordinary social drinking has a weak stimulatory action on pancreatic bicarbonate secretion and that this action is not mediated by release of secretin.
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005755:Gastrins / Q000097:blood; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008297:Male; D010189:Pancreatic Juice / Q000378:metabolism*; D012633:Secretin / Q000097:blood
D001639:Bicarbonates; D005755:Gastrins; D012633:Secretin; D000431:Ethanol; D005947:Glucose