Kainic acid-induced terminal degeneration in the dorsal lateral geniculate of tree shrew.
The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of the geniculate nucleus. The actions of kainic acid upon both the presynaptic terminals and geniculate neurons may be mediated by a glutamatergic pathway and questions the hypothesis that kainic acid is solely neuron-specific in its toxic action.
D000818:Animals; D005829:Geniculate Bodies / Q000187:drug effects* / Q000473:pathology; D006735:Horseradish Peroxidase; D007608:Kainic Acid / Q000633:toxicity*; D009410:Nerve Degeneration / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000378:metabolism; D014418:Tupaiidae / Q000502:physiology*; D014795:Visual Pathways / Q000187:drug effects / Q000473:pathology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D007608:Kainic Acid