title: [Interaction of local anesthetics with bilayer phospholipid membranes].
abstract: Local anesthetics--cocaine, lidocaine, novocaine were tested for conductivity of bilayer lipid membranes containing anion-selective channels formed by polyene antibiotic amphotericin B. It has been shown that 5 X 10(-4) M cocaine doubles the membrane conductance. The line of efficiency of the tested anesthetics is: cocaine greater than lidocaine greater than novocaine. Possible molecular mechanism of the discovered effect is discussed.
mesh_terms: D000666:Amphotericin B / Q000378:metabolism; D000779:Anesthetics, Local / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology; D008051:Lipid Bilayers; D008564:Membrane Potentials / Q000187:drug effects; D010743:Phospholipids; D011343:Procaine / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D007473:Ion Channels; D008051:Lipid Bilayers; D010743:Phospholipids; D011343:Procaine; D000666:Amphotericin B; D008012:Lidocaine; D003042:Cocaine
vernacular_title: Vzaimodeĭstvie lokal'nykh anestetikov s bisloĭnymi fosfolipidnymi membranami.