[Effect of nonsteroidal anti-inflammatory agents on protein and nucleic acid levels in a focus of aseptic proliferative inflammation].
In experiments on albino rats on the model of "cotton wool granuloma" it was found that non-steroidal anti-inflammatory agents inhibited the growth of the granulation and fibrous tissue that was followed by a normal decrease of contents of protein and RNA but not DNA in it. By their effect on RNA and granuloma weight butadione and mefenamic acid are significantly more active than antipyrine.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011506:Proteins; D012313:RNA; D004247:DNA
Vliianie nesteroidnykh protivovospalitel'nykh sredstv na soderzhanie belka i nukleinovykh kislot v ochage asepticheskogo proliferativnogo vospaleniia.