Identification of a neutralizing epitope shared by bluetongue virus serotypes 2 and 13.
The serotypes of bluetongue virus (BTV) are classified by differences in neutralization commonly induced by P2, a major surface protein. A BTV serotype 13 (BTV-13) monoclonal antibody, 4B13-207A, immunoprecipitated P2s of BTV-13 and BTV-2 and also neutralized both viruses. These data indicate that P2s from BTV-13 and BTV-2 share a common neutralizing epitope that is not detected by neutralizing polyclonal antibody to BTV-13.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D001820:Bluetongue virus / Q000145:classification / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D009500:Neutralization Tests; D012087:Reoviridae / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins