[Age-related characteristics of the effect of denervation and axonal transport blockade on the electrical characteristics of skeletal muscle fibers].
The denervation and colchicine-induced changes of resting MP, electroexcitability threshold, amplitude and duration of the AP peak were studied in m. extensor digitorum longus and m. soleus of adult and old rats. In the latter, the neurotrophic control of the sarcolemma electrical properties was weakened, this being more obvious in the red muscle. The age changes of neurotrophic control are one of the causes of disturbances of the sarcolemma electrical properties in skeletal muscle fibers of old animals. The weakening of neurotrophic control may be due to the decrease of axonal transport rate in old age.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D004594:Electrophysiology; D009121:Muscle Denervation; D009132:Muscles / Q000502:physiology*; D051381:Rats
D003078:Colchicine
Vozrastnye osobennosti vliianiia denervatsii i blokady aksotoka na élektricheskie kharakteristiki skeletnykh myshechnykh volokon.