Immunological cross-reactivity of a Mycoplasma pneumoniae membrane-associated protein antigen with Mycoplasma genitalium and Acholeplasma laidlawii.
A murine monoclonal antibody, OC2F5, reacts with a Mycoplasma pneumoniae antigen with an approximate Mr of 43,000. This antigen is trypsin and proteinase K sensitive and partitions in the detergent phase of a Triton X-114 solution. The monoclonal antibody cross-reacts with an antigen from both Mycoplasma genitalium and Acholeplasma laidlawii with a similar molecular weight. This cross-reactivity should be considered in the development of M. pneumoniae antigen detection systems based on the use of antibodies directed to this protein antigen.
D000128:Acholeplasma laidlawii / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005260:Female; D006825:Hybridomas; D007118:Immunoassay; D051379:Mice; D009174:Mycoplasma / Q000276:immunology*; D009177:Mycoplasma pneumoniae / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D000939:Epitopes