title: Delayed pressure urticaria syndrome: a clinical expression of interleukin 1.
abstract: Study of a patient with the bullous delayed pressure urticaria syndrome showed remarkable congruence of the extra-cutaneous findings and the known effects of interleukin 1: malaise, fever, myalgia, arthralgia, leukocytosis, increased sedimentation rate, and circulating acute phase reactants. As a result of this "clinical assay" for interleukin 1, we conclude that the delayed pressure urticaria syndrome is the clinical expression of interleukin 1, synthesized in the skin as a result of pressure and released into the circulation. Delayed urticaria, mediated by interleukin 1, is to be contrasted with immediate type urticaria, long known to be histamine mediated.
mesh_terms: D000328:Adult; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D008297:Male; D011312:Pressure / Q000009:adverse effects; D013577:Syndrome; D013997:Time Factors; D014581:Urticaria / Q000209:etiology* / Q000276:immunology
chemical_list: D007375:Interleukin-1