The M gamma chain of human fetal hemoglobin; its identification and occurrence.
High-performance liquid chromatographic procedures have been used in the detection and identification of a new gamma chain of human fetal hemoglobin (Hb). This M gamma chain is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been observed. The M gamma chain has been detected in red cell lysates of subjects with a heterozygosity for one of many types of so-called hereditary persistence of fetal hemoglobin conditions, which are characterized by an increased level of Hb F in adult life, in sickle cell anemia, and in a few cord blood samples. At present it is not possible to definitely identify the genetic cause of this newly discovered heterogeneity; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.
D000596:Amino Acids / Q000032:analysis; D000755:Anemia, Sickle Cell / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000032:analysis; D005312:Fetal Blood / Q000032:analysis; D005319:Fetal Hemoglobin / Q000032:analysis*; D005914:Globins / Q000032:analysis / Q000302:isolation & purification; D006801:Humans
D000596:Amino Acids; D005914:Globins; D005319:Fetal Hemoglobin