Molecular cloning of a protective antigen of schistosomes.
The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D006224:Cricetinae; D000939:Epitopes; D008970:Molecular Weight; D010215:Papio; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012547:Schistosoma / Q000276:immunology; D012550:Schistosoma mansoni / Q000235:genetics* / Q000276:immunology; D012552:Schistosomiasis / Q000517:prevention & control; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D013045:Species Specificity
D000947:Antigens, Helminth; D000954:Antigens, Surface; D000939:Epitopes; D011993:Recombinant Fusion Proteins