title: The effect of doxorubicin on slow and fast components of the axonal transport system in rats.
abstract: The study was designed to investigate the changes in axonal transport that result from disturbances in protein synthesis. Doxorubicin, an antineoplastic drug which interferes with the function of DNA, has a selective effect on peripheral sensory nerves because of the high vascular permeability in the dorsal root ganglia. After the intravenous administration of a moderate dose (4 mg/kg) to male Wistar rats, the transport of slow component a (SCa) was found to be retarded, transport velocity being decreased by 17% (0.85 +/- 0.06 mm/day vs 1.03 +/- 0.06 mm/day in controls). The transport kinetics of the fast anterograde and retrograde components (aFC and rFC) were unchanged after the administration of a dose of 6 mg/kg, although the relative amount of aFC was decreased by 27% (3.2 +/- 0.9% vs 4.4 +/- 1.1% in controls). It is suggested that the neuronopathy induced by doxorubicin is mediated by changes in axonal transport.
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology*; D005643:Fucose / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000378:metabolism; D009475:Neurons, Afferent / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects
chemical_list: D005643:Fucose; D004317:Doxorubicin; D008715:Methionine