Oncodevelopmental carbohydrate antigens: distribution of ECMA 2 and 3 antigens in embryonic and adult tissues of the mouse and in teratocarcinomas.
Immunohistochemical studies revealed the oncodevelopmental nature of two carbohydrate antigens, ECMA 2 and ECMA 3. In the mouse, the antigens were first detected in late 1-cell embryos, markedly expressed until the early post-implantation stage and progressively disappeared thereafter. They were hardly detectable at day 9-10 of embryogenesis but were present in primordial germ cells until day 12. In adult mice the antigens were present in the oviduct and cauda epididymis. Pregnancy induced expression of the antigens was observed in the uterus. The nasal chamber of the embryo and some cells in the small intestine of the adult were the only two additional sites where one or two of the antigens were significantly detected. Thus, ECMA 2 and 3 antigens were closely related to early embryogenesis and reproduction. Although expression of ECMA 2 paralleled that of ECMA 3 in normal mice, their distributions were significantly different in teratocarcinoma cells.
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001755:Blastocyst / Q000276:immunology; D002241:Carbohydrates / Q000276:immunology*; D004622:Embryo, Mammalian / Q000276:immunology*; D005314:Embryonic and Fetal Development; D000939:Epitopes / Q000235:genetics* / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013724:Teratoma / Q000276:immunology*; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D002241:Carbohydrates; D000939:Epitopes