Immunohistochemistry of the blood group A,B,H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix.
Currently, there is lack of a histologic classification of squamous cell carcinoma of the cervix that correlates significantly with patient survival. This study investigated the survival predictive value of two immunohistochemical markers, the blood group A,B,H isoantigens and the Oxford Ca antigen, on conventional histologic sections of tumor tissues from 85 surgically treated patients with Stage IB squamous cell cervical cancer. The results indicated that the two antigens are two distinct markers, neither of which correlates with tumor grade. The expression of the A,B,H isoantigens is significantly related to patient survival after adjustment for the depth of stromal invasion of the tumor, whereas the Oxford Ca antigen has no survival predictive value.
D000017:ABO Blood-Group System / Q000276:immunology*; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000401:mortality; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging / Q000379:methods; D010865:Pilot Projects; D011379:Prognosis; D012107:Research Design; D013194:Staining and Labeling; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000401:mortality
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate