An analysis of infiltrating cells in human ringworm.
Immunohistochemically we examined six patients with ringworm which exhibited a well-marked erythematous edge and central resolution. To obtain a panoramic view of the immunopathological features of various evolutionary stages of skin lesion, we took a radial slice biopsy specimen extending from normal-appearing skin to central resolution. The actively involved edge had a moderate amount of dermal infiltrate of mononuclear cells which mostly consisted of T cells. The ratio of the helper T cells to suppressor T cells was 3.4. At the central resolution, the dermal infiltrate was mild, and the helper T/suppressor T ratio was 3.0. The well-marked erythematous edge showed a decrease of OKT6 positive Langerhans' cells in the epidermis, while many OKT6 positive cells were present in the upper dermis. At the central resolution, however, OKT6 positive cells increased in number in the acanthotic epidermis.
D000328:Adult; D000911:Antibodies, Monoclonal; D004817:Epidermis / Q000473:pathology; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008214:Lymphocytes / Q000145:classification / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D013194:Staining and Labeling; D014005:Tinea / Q000473:pathology*
D000911:Antibodies, Monoclonal