Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids.
The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D016030:Kidney Transplantation; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D016559:Tacrolimus; D014839:Vomiting / Q000139:chemically induced
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011725:Pyridines; D011239:Prednisolone; D016559:Tacrolimus