[Release of plasminogen activator by pentosan polysulfate].
In isolated perfused organs (pig ear, rabbit ear, rat lung) pentosan polysulphate caused an increase in the release of plasminogen activator. The activator was released in a dose-dependent manner, the release being repeatedly induced as demonstrated with the rabbit ear. An increase in activator activity was also found in experimental animals (mini-pig, rat, rabbit). In the isolated perfused organ and the whole animal, the activator released proved to be tissue-type plasminogen activator. For the release mechanism displacement of mural plasminogen activator by pentosan polysulphate seems to be of importance. The release of tissue-type activator plays a decisive role for the regulation of the temporarily insufficient fibrinolytic system, for the thrombolytic process and for the antithrombotic action of pentosan polysulphate.
D000818:Animals; D000933:Antifibrinolytic Agents; D004423:Ear; D005260:Female; D005341:Fibrinolysin / Q000032:analysis; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D010477:Perfusion; D010958:Plasminogen / Q000032:analysis; D011134:Polysaccharides / Q000494:pharmacology*; D011655:Pulmonary Embolism / Q000097:blood; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012712:Serum Globulins / Q000032:analysis; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000378:metabolism*; D000979:alpha-2-Antiplasmin / Q000032:analysis
D000933:Antifibrinolytic Agents; D011134:Polysaccharides; D012712:Serum Globulins; D000979:alpha-2-Antiplasmin; C037742:plasmin-plasmin inhibitor complex; D010426:Pentosan Sulfuric Polyester; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin
Zur Freisetzung von Plasminogenaktivator durch Pentosanpolysulfat.