Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K-ATPase.
The reduction of vanadate (+5V) to vanadyl (+4V) was demonstrated by ESR spectra in the presence of methylene-blue, chlorpromazine, imipramine and dosulepin, but not in the presence of benzodiazepines and Li+. Bleomycine forms an (inactive) complex with +4V which may explain the disinhibition of the brain microsomal Na+-K+ ATPase in the presence of vanadyl. The reduction of +5V to +4V by antidepressants would diminish the binding of +5V to the ATPase and could account for some of the therapeutic action of the drugs in manic-depressive illness.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002746:Chlorpromazine / Q000494:pharmacology; D004308:Dothiepin / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D010084:Oxidation-Reduction; D011619:Psychotropic Drugs / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014638:Vanadates; D014639:Vanadium / Q000378:metabolism*
D011619:Psychotropic Drugs; D014639:Vanadium; D001761:Bleomycin; D014638:Vanadates; D000254:Sodium-Potassium-Exchanging ATPase; D007099:Imipramine; D002746:Chlorpromazine; D004308:Dothiepin