Pleomorphic adenoma and adenoid-cystic carcinoma of the salivary glands: comparative immunohistochemical patterns.
A series of 20 cases of pleomorphic adenoma and 19 cases of adenoid-cystic carcinoma of the salivary glands, and one case in the mammary location, were investigated regarding immunohistochemical reactivity for Tissue Polypeptide Antigen (TPA), Pre-Keratins, Vimentin, S-100 Protein, and their arrangement pattern of fibronectin. As a whole, the results support the hypothesis of morpho-structural and mainly, onto-histogenetic similarities between these tumours, but they also underline the need for great care in outlining their morpho-functional features, in relation to their different prognoses.
D008949:Adenoma, Pleomorphic / Q000032:analysis*; D003528:Carcinoma, Adenoid Cystic / Q000032:analysis*; D005353:Fibronectins / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D010307:Parotid Neoplasms / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D011498:Protein Precursors / Q000032:analysis; D017293:Protein S; D011506:Proteins / Q000032:analysis*; D019396:Tissue Polypeptide Antigen; D014746:Vimentin / Q000032:analysis
D005353:Fibronectins; D006023:Glycoproteins; D010455:Peptides; D011498:Protein Precursors; D017293:Protein S; D011506:Proteins; D019396:Tissue Polypeptide Antigen; D014746:Vimentin; C004818:prekeratin; D007633:Keratins