[Effect of Iloprost (ZK 36 374) on hemodynamic parameters during kidney donor conditioning in animal experiments].
Hemodynamic parameters during the conditioning of kidney donors were tested under the influence of Iloprost (ZK 36 374), a stable prostacyclin derivate, in 12 house swine of a body weight of 20-50 kg. The electromagnetically measured blood flow in the right renal artery increased on an average of 73.2% after intraaortic infusion of Iloprost (1 micrograms/kg.min) during 15 minutes. The mean arterial blood pressure decreased simultaneously by 14.7%. The renal flow resistance (RVR), by blood pressure and blood flow calculated, decreased by 49.7% in average. Iloprost appears well-suitable for conditioning donors, it shows advantages in contrast to the hitherto used drugs.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology*; D016285:Iloprost; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D016030:Kidney Transplantation; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects; D013552:Swine; D014019:Tissue Donors; D014655:Vascular Resistance / Q000187:drug effects
D002317:Cardiovascular Agents; D011464:Epoprostenol; D016285:Iloprost
Der Einfluk von Iloprost (ZK 36 374) auf hämodynamische Parameter während der Nierenspenderkonditionierung im Tierexperiment.