Expression of transferrin receptor on human carcinomas--an immunohistological study.
Thirty specimens taken from 25 adenocarcinomas, 1 squamous cell carcinoma, 2 anaplastic carcinomas and 2 malignant lymphomas were studied for the presence of transferrin receptor (TR). Immunoperoxidase technique was used and OKT9, an anti-transferrin receptor monoclonal antibody, was introduced. The tissue localization of carcino-embryonic antigen (CEA) and epithelial membrane antigen (EMA) were also studied. Of these, 5 cases were strongly stained for TR, 17 moderately and 6 weakly stained. TR was demonstrated on the basal site while luminal preference was evident with CEA and EMA. This polarity was observed in the well- to moderately-differentiated adenocarcinomas and in the well-differentiated squamous cell carcinoma but not in the poorly-differentiated and anaplastic variants. Putatively normal epithelium registered very weak positivity though the polarity was still maintained.
D000230:Adenocarcinoma / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D006801:Humans; D007158:Immunologic Techniques; D008223:Lymphoma / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D018396:Mucin-1; D009369:Neoplasms / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism*; D013194:Staining and Labeling
D002272:Carcinoembryonic Antigen; D008565:Membrane Proteins; D018396:Mucin-1; D011990:Receptors, Transferrin