[Effect of polymer-immobilized cortisol on 3H-uridine incorporation into the thymocyte RNA of rats].
It was found that cortisol immobilized on polyvinylpyrrolidone (PVP-GC) suppresses the incorporation of 3H-uridine into RNA of thymocytes of intact but not adrenalectomized rats. PVP-GC at the concentration of 10(-6) M enhanced the inhibiting effect of dexamethasone (10(-9) M) and cortisol (10(-9) M) on RNA biosynthesis in thymocytes of adrenalectomized animals.
D000315:Adrenalectomy; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D011205:Povidone; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D014316:Tritium; D014529:Uridine / Q000378:metabolism*
D014316:Tritium; D012313:RNA; D011205:Povidone; D014529:Uridine; D006854:Hydrocortisone
Vliianie kortizola, immobilizovannogo na polimere, na vkliuchenie 3H-uridina v RNK timotsitov krys.