Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1.
Measles virus suppresses T lymphocyte functions in vitro. When measles virus-infected T lymphocytes are stimulated with PHA or 12-O-tetradecanoylphorbol-13-acetate, plus calcium ionophore, the cells secrete IL-2 and express the IL-2R or Tac Ag to a similar extent as uninfected cells, yet proliferation is reduced by 50 to 90%. Stimulated infected T cells also express the cell surface activation Ag 4F2, transferrin R, and HLA-DR. The secretion of IFN-gamma by infected T cells in response to PHA is not suppressed at 24 to 72 h after stimulation. Total RNA synthesis at 48 and 72 h after stimulation is reduced in infected T lymphocytes. Infectious measles virus progeny are produced during this interval. Thus infected T lymphocytes can become activated in response to mitogenic stimuli and the cells support efficient viral replication before the block in cell proliferation.
D002455:Cell Division / Q000187:drug effects; D004987:Ethers / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism; D007399:Interphase; D015759:Ionomycin; D008213:Lymphocyte Activation / Q000187:drug effects; D008459:Measles virus / Q000502:physiology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014779:Virus Replication
D004987:Ethers; D010835:Phytohemagglutinins; D015759:Ionomycin; D012313:RNA; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate