Predictive value of C-reactive protein in neonatal septicaemia.
The following non-specific indices of infection were studied in septicaemic and non-septicaemic babies: haemoglobin, total white blood cell count, differential white count, ESR, platelet count, C-reactive protein (CRP), serum immunoglobulins, plasma C3 and haptoglobin. Forty-three low-birthweight (LBW) infants with clinical features suggesting septicaemia were investigated; blood cultures were positive in 19 and negative in 24. The mortality was 53% in the culture-positive and 13% in the culture negative group. Comparisons between the two groups of babies showed that the CRP titre (measured by Latex agglutination) was the only reliable non-specific indicator of infection. The titre was elevated more often in culture positive (16/19) than culture negative (7/17) babies (P less than 0.001). The CRP titre (Mean +/- 2 S.D.) was 15.75 +/- 12 in blood culture positive and 6.13 +/- 11.72 in culture negative neonates respectively (P less than 0.0004). Positive CRP titres were found in 5 of 20 healthy controls (4 +/- 8.4). Sequential CRP titres showed a gradual decline with clinical improvement in both groups of patients. The IgM was unhelpful as it was raised (greater than or equal to 40 mg%) in 37 of the patients.
D002097:C-Reactive Protein / Q000032:analysis* / Q000276:immunology; D005069:Evaluation Studies as Topic; D006403:Hematologic Tests; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000175:diagnosis; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D007841:Latex Fixation Tests; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
D007136:Immunoglobulins; D002097:C-Reactive Protein