Accumulation of c-src mRNA is developmentally regulated in embryonic neural retina.
Accumulation of c-src mRNA gradually increased during early development of the neural retina in chicken embryos and reached a peak by days 11 to 13 of embryonic life. Thereafter, its amount declined to a low level which persisted also in adult retina. The early increase in c-src mRNA correlated inversely with the decrease in the amount of H3.2 replication histone mRNA and with the decline in the rate of cell growth. The accumulation profile of c-src mRNA corresponded to that of pp60c-src protein, suggesting that the latter is regulated at the level of transcription.
D000818:Animals; D002642:Chick Embryo; D005314:Embryonic and Fetal Development; D005796:Genes; D005809:Genes, Regulator; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016392:Proto-Oncogene Proteins pp60(c-src); D012333:RNA, Messenger / Q000235:genetics*; D012160:Retina / Q000196:embryology* / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D016392:Proto-Oncogene Proteins pp60(c-src)