title: Treatment strategies of testicular cancer in the United States.
abstract: The treatment of testicular cancer has dramatically improved during the past decade. Combination chemotherapy with PVB was instituted at Indiana University in 1974. Subsequent studies demonstrated that: post PVB, surgery can cure patients; vinblastine dosage can be lowered from 0.4 to 0.3 mg/kg without sacrificing cure potential; maintenance vinblastine is not necessary; VP-16 can be substituted for vinblastine with equivalent cure rates and decreased neuromuscular toxicity.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011897:Random Allocation; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014481:United States; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin