title: Demonstration of perivascular peptides and changes in concentration with age in man.
abstract: By immunocytochemistry, human cerebral arteries have been found to be invested by perivascular fibres which contain neuropeptide Y, substance P and vasoactive intestinal polypeptide (VIP). The concentrations of the peptides are comparable for substance P and VIP, whereas that of neuropeptide Y is much higher. A marked reduction in radioimmunoassayable peptide levels was observed with advancing age of the patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002536:Cerebral Arteries / Q000032:analysis / Q000294:innervation*; D002648:Child; D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y; D011863:Radioimmunoassay; D013373:Substance P / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide