Delivery of antifibroblast agents as adjuncts to filtration surgery--Part II: Delivery of 5-fluorouracil and bleomycin in a collagen implant: pilot study in the rabbit.
A pilot study was performed in order to determine if filtration bleb longevity could be enhanced in rabbits by delivery of 5-fluorouracil or bleomycin in a collagen sponge implant. Results showed that both agents prolonged bleb longevity and lowered intraocular pressure when compared to controls. Bleomycin treated animals had the best bleb appearance and function at the longest postoperative intervals.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D003094:Collagen; D004343:Drug Implants; D005123:Eye / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D005901:Glaucoma / Q000601:surgery*; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D010865:Pilot Projects; D011182:Postoperative Care; D011817:Rabbits
D004343:Drug Implants; D001761:Bleomycin; D003094:Collagen; D005472:Fluorouracil