Role of brain monoaminergic systems in the increased ethanol drinking caused by REM-sleep deprivation.
The central monoaminergic neuronal effects of REM-sleep deprivation, and the effect of different monoamine uptake blocking agents on the REM-sleep deprivation-induced increase in ethanol intake were studied. The levels of 5-HT and 5-HIAA in the hypothalamus were increased both in the REM-sleep deprived rats and the stressed control rats, but the hypothalamic level of MHPG was decreased only in the REM-sleep deprived animals. Two daily injections (5-20 mg/kg/d) of citalopram or GBR-12909 (uptake blocking agents for 5-HT and dopamine, respectively) did not modify the increased level of ethanol intake. The noradrenaline uptake blocking agent, talsupram (5-10 mg/kg/d), however, decreased ethanol intake to the levels seen prior to deprivation. This effect of talsupram could be antagonized by blocking alpha-1-adrenoreceptors with prazosin (1 mg/kg/d).
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000428:Alcohol Drinking / Q000187:drug effects; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000032:analysis*; D015283:Citalopram; D004298:Dopamine / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D010879:Piperazines / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000032:analysis; D012892:Sleep Deprivation; D012895:Sleep, REM; D013876:Thiophenes / Q000494:pharmacology
D002395:Catecholamines; D010879:Piperazines; D011437:Propylamines; D013876:Thiophenes; D015283:Citalopram; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; C043425:vanoxerine; C001750:talsupram; D004298:Dopamine; D009638:Norepinephrine; D011224:Prazosin