title: Effect of changes in the rate of ionophore A23187-induced calcium influx on the pump-leak steady-state distribution of calcium in inosine-fed human red cells.
abstract: We studied the effect of varying the rate of ionophore A23187-induced calcium influx on the mean calcium content of inosine-fed human red cells in pump-leak steady state. Slow calcium infusion caused only a marginal reduction in the mean calcium content of cells in the steady state relative to their content after sudden calcium addition.
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007288:Inosine / Q000494:pharmacology*; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics
chemical_list: D007473:Ion Channels; D000001:Calcimycin; D007288:Inosine; D000255:Adenosine Triphosphate; D002118:Calcium