title: Vaccinia-mediated rescue of encephalomyocarditis virus from the inhibitory effects of interferon.
abstract: Coinfection of mouse L cells with vaccinia virus rescues encephalomyocarditis virus (EMC) from the inhibitory effect of interferon (IFN). The vaccinia-mediated rescue of EMC growth increases the yield of EMC as much as 1000-fold and is optimum when vaccinia is used at a multiplicity of infection of 1. This rescue correlates with a vaccinia-dependent stimulation of EMC gene expression. Evidence is presented to indicate that the rescue by vaccinia does not involve a block of the 2'-5'A synthetase pathway. However, the vaccinia rescue function is correlated with a vaccinia-mediated inhibition of the IFN-induced protein kinase.
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000818:Animals; D004686:Encephalomyocarditis virus / Q000254:growth & development*; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D012367:RNA, Viral / Q000096:biosynthesis; D014616:Vaccinia virus / Q000502:physiology*; D014764:Viral Proteins / Q000096:biosynthesis
chemical_list: D047428:Protein Kinase Inhibitors; D012335:RNA, Ribosomal; D012367:RNA, Viral; D014764:Viral Proteins; D007372:Interferons; D011494:Protein Kinases; D015088:2',5'-Oligoadenylate Synthetase