[Effects of nicergoline on artificially induced micturition in the rabbit with and without prostatic hypertrophy].
An original experimental model of prostatism is proposed: Prostatic hypertrophy was induced in rabbit by testosterone 5 mg/kg-1. Three days later an increased number of micturitions, a correlate decrease in volume and an increased premictionnal vesical pressure were observed during a perfusion of the bladder in situ by NaCl 1 ml min-1. Phenoxybenzamine was not deeply studied because a lack of satisfaisant dose action-curve. I.V. administration of low doses of nicergoline (50 to 250 mcg/kg-1) reduced the consequences of the induced prostatic hypertrophy on the micturitions. These results are considered as a confirmation of a greater number of alpha 1-adrenoceptors in the bladder than in detrusor and allow us to confirm the use of nicergoline as a medical treatment of urinary retention in prostatic hypertrophy.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D009530:Nicergoline / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000503:physiopathology*; D011817:Rabbits; D012965:Sodium Chloride / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology; D014554:Urination / Q000187:drug effects*
D004873:Ergolines; D010643:Phenoxybenzamine; D013739:Testosterone; D012965:Sodium Chloride; D009530:Nicergoline
Effets de la nicergoline, sur la miction artificiellement provoquée, chez le lapin présentant ou non une hypertrophie prostatique.