Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat.
Combined immunohistochemistry and retrograde tracing was used to investigate the origin of the sensory calcitonin gene-related peptide (CGRP) innervation of the rat stomach. Up to 85% of spinal gastric afferents (T6-L1) contained CGRP immunoreactivity compared with less than 6% of vagal gastric afferents. By comparison substance P immunoreactivity occurred in about 50% of spinal gastric afferents and less than 2% of vagal afferents. The vagal afferents to the oesophagus were 14 and 26% substance P- and CGRP-immunoreactive respectively. The results suggest an important role for CGRP in gastric spinal afferents.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D004947:Esophagus / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000378:metabolism; D008297:Male; D009475:Neurons, Afferent / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D009620:Nodose Ganglion / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013127:Spinal Nerves / Q000378:metabolism*; D013270:Stomach / Q000294:innervation*; D013373:Substance P / Q000378:metabolism*; D014630:Vagus Nerve / Q000378:metabolism*
D009479:Neuropeptides; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide