Role of immune complexes in pathogenesis of renal disease.
When judged by histological criteria, kidney tissue is practically devoid of immune tissue; as yet a broad spectrum of immunological diseases are targeted at the kidneys, especially at the glomeruli. Glomerular epithelial cells exhibit immune protein receptors and hence could clear immune complexes decorated with complement from the circulation. Alternatively, circulating immune complexes could become trapped in the glomerular filter and start off inflammatory reactions. Anti-glomerular basement membrane antibody reacts with glomeruli and causes glomerulonephritis. The present text is an analysis of the impact of immune complex formation on renal pathology and contains retrospective clinical data of our own hospital obtained on 192 patients undergoing diagnostic renal biopsy.
D003165:Complement System Proteins / Q000276:immunology; D000939:Epitopes; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology* / Q000628:therapy; D007136:Immunoglobulins / Q000276:immunology; D007674:Kidney Diseases / Q000276:immunology* / Q000628:therapy
D000939:Epitopes; D007136:Immunoglobulins; D003165:Complement System Proteins