Chemotherapy-radiotherapy combination in the treatment of carcinoma of the cervix.
Three hundred eligible patients with carcinoma of the cervix out of a total of 560, registered between July 1981 and June 1983 were randomized into receiving either radiotherapy alone or radiotherapy plus weekly injection of bleomycin 15 mg and mitomycin C4 mg. To date (22 Feb. 1985) patients have been evaluated for response to therapy at 3 months and 1 year from completion of treatment. Although both at 3 months and 1 year the combined modality treatment appears to be marginally better (68% and 71% at 3 months, 56% and 63% at 1 year), the long term results remain uncertain at present. Treatment by the addition of chemotherapy to radiation was however well tolerated with a few complications.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009367:Neoplasm Staging; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D008937:Mitomycins; D001761:Bleomycin; D016685:Mitomycin