HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.
Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope.
D002460:Cell Line; D000939:Epitopes / Q000032:analysis*; D006680:HLA Antigens / Q000276:immunology*; D015235:HLA-B Antigens; D059912:HLA-B37 Antigen; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007376:Interleukin-2; D009698:Nucleoproteins / Q000276:immunology*; D010641:Phenotype; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens; D059912:HLA-B37 Antigen; D007376:Interleukin-2; D009698:Nucleoproteins; D014764:Viral Proteins