Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.
A portion of the human cellular homolog of v-rel, the transforming gene of the leukemogenic retrovirus reticuloendotheliosis virus, strain T, was used to survey RNAs from several mouse tissues, selected lymphocyte populations, and hematopoietic cell lines for c-rel expression. Relatively high levels of a high-molecular-weight transcript were observed in peripheral B and T cells, whereas lower levels were detectable in functionally immature thymocytes. These results suggested that, unlike c-myb and c-ets, the c-rel proto-oncogene plays a role in later stages of lymphocyte differentiation.
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000235:genetics; D006410:Hematopoiesis; D006413:Hematopoietic System / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012313:RNA; D004247:DNA