LAV/HTLV-III antibodies in patients treated with intravenous gammaglobulins.
The test sera from 50 patients treated with intravenous gammaglobulins (IVG) were examined for LAV/HTLV-III antibody by ELISA tests in order to evaluate the risk of transmission of LAV/HTLV-III virus via administration of IVG. The three ELISA-positive sera were negative for the antibody by both indirect immunofluorescence assay (IFA) and Western blot assay (WBA). Thus, all of the test sera were negative for LAV/HTLV-III antibody. Two of the ELISA-positive/IFA-negative/WBA-negative samples had HLA-DR4 antibodies causing positive ELISA results.
D000914:Antibodies, Viral / Q000032:analysis*; D003101:Collodion; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006801:Humans; D005719:gamma-Globulins / Q000009:adverse effects*
D000914:Antibodies, Viral; D015483:HIV Antibodies; D005719:gamma-Globulins; D003101:Collodion