Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus.
Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw3/4-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.
D001323:Autoantibodies / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D000939:Epitopes / Q000032:analysis; D005109:Extracellular Matrix / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010179:Pancreas / Q000276:immunology*; D010375:Pedigree
D001323:Autoantibodies; D000939:Epitopes; D006681:HLA-D Antigens