LAV/HTLV-III gag gene product p24 shares antigenic determinants with equine infectious anemia virus but not with visna virus or caprine arthritis encephalitis virus.
Antigenic cross-reactivity of the human acquired immunodeficiency disease syndrome virus LAV/HTLV-III with the lentiviruses visna virus, caprine arthritis encephalitis virus (CAEV), and equine infectious anemia virus (EIAV) was determined with indirect enzyme-linked immunosorbent assays, immunoblot analysis, and virus-specific polyclonal antisera. Nonreciprocal cross-reactivity was seen between the gag gene products p24 of LAV/HTLV-III and p28 of EIAV. Reciprocal cross-reactivity was seen between the gag gene product p28 of visna virus and CAEV. No cross-reactivity was detected between visna virus (or CAEV) and EIAV (or LAV/HTLV-III). This suggests a closer relationship of LAV/HTLV-III with EIAV than with visna virus or CAEV.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D003429:Cross Reactions; D000939:Epitopes; D015683:Gene Products, gag; D006678:HIV / Q000276:immunology*; D004860:Infectious Anemia Virus, Equine / Q000276:immunology*; D012190:Retroviridae / Q000145:classification* / Q000276:immunology; D012191:Retroviridae Proteins / Q000276:immunology*; D013045:Species Specificity; D014790:Visna-maedi virus / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D015683:Gene Products, gag; D012191:Retroviridae Proteins