A new T helper cell specificity within the pigeon cytochrome c determinant 95-104.
A T cell hybridoma with unusual antigen specificity has been isolated from B10.BR mice immunized with pigeon cytochrome c. Using synthetic peptide analogues of the pigeon cytochrome c T cell determinant 81-104 we have determined that this hybridoma is specific for residues within the sequence 95-104. However, the mode by which this T cell hybridoma recognizes this determinant in the context of the I-Ek molecule differs from all previously described T cell clones in that it is not stimulated by the moth cytochrome c analogue 81-103.
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D010856:Columbidae / Q000097:blood / Q000276:immunology*; D003574:Cytochrome c Group / Q000276:immunology*; D000939:Epitopes / Q000032:analysis* / Q000276:immunology / Q000302:isolation & purification; D006825:Hybridomas / Q000166:cytology / Q000276:immunology*; D007114:Immunization; D010455:Peptides / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D003574:Cytochrome c Group; D000939:Epitopes; D010455:Peptides