Interaction of steady-state procainamide with H2-receptor antagonists cimetidine and ranitidine.
This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on steady-state procainamide pharmacokinetics. Six healthy men were given 500 mg sustained-release procainamide every 6 h, for a total of 13 doses, on three occasions. Subjects were randomly assigned to three treatments by a Latin-square design: cimetidine 1,200 mg/day, ranitidine 300 mg/day, and no H2-receptor antagonist (control) for 4 days. Cimetidine significantly increased the procainamide area under the serum concentration-time curve by 43%, decreased renal clearance by 36%, and decreased the ratio of systemic clearance of procainamide to bioavailability by 28%. Ranitidine did not significantly alter procainamide steady-state pharmacokinetics.
D000120:Acecainide / Q000493:pharmacokinetics; D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011342:Procainamide / Q000493:pharmacokinetics*; D011899:Ranitidine / Q000494:pharmacology*
D002927:Cimetidine; D011899:Ranitidine; D000120:Acecainide; D011342:Procainamide