Increased availability of phosphoribosyl pyrophosphate as the basis for enhanced 6-mercaptopurine incorporation by methotrexate, in cultured human lymphoblasts.
D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D015122:Mercaptopurine / Q000378:metabolism*; D008727:Methotrexate / Q000494:pharmacology*; D010428:Pentosephosphates / Q000378:metabolism*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D010428:Pentosephosphates; D011687:Purines; D010754:Phosphoribosyl Pyrophosphate; D015122:Mercaptopurine; D008727:Methotrexate