[Effective complexes of the antileukemic enzyme L-asparaginase with dextran sulfate].
Enzymatic and antileukemic effects of the complexes of L-asparaginase from E. coli and biologically active polymer dextran sulfate were studied to increase their therapeutic properties. The complex was characterized by more distinct substrate specificity, by an increase in the stability during storage, in thermostability as well as in the resistance to proteolysis. The increased antileukemic activity of the complex was observed in experimental lymphoid leukemia L5178y in mice. Use of the complex of L-asparaginase and dextran sulfate enabled to decrease distinctly the therapeutic dose of the enzyme.
D000818:Animals; D001215:Asparaginase / Q000032:analysis / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D016264:Dextran Sulfate; D003911:Dextrans / Q000008:administration & dosage*; D004355:Drug Stability; D007940:Leukemia L5178 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice
D003911:Dextrans; D016264:Dextran Sulfate; D001215:Asparaginase
Effektivnye kompleksy protivoleĭkoznogo fermenta L-asparaginazy s dekstransul'fatom.