Prevention of experimental pancreatitis by somatostatins.
Somatostatin is known to exert a beneficial cytoprotective effect in acute experimental pancreatitis, although it is ineffective regarding mortality in human pancreatitis. The somatostatin analog 008 was found to be more efficient in taurocholate-induced pancreatitis in rats and in ceruletid-induced pancreatitis.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002108:Ceruletide / Q000037:antagonists & inhibitors; D005260:Female; D010189:Pancreatic Juice / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000378:metabolism; D010195:Pancreatitis / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013656:Taurocholic Acid / Q000031:analogs & derivatives
D013004:Somatostatin; D010191:Pancreatic Polypeptide; D013656:Taurocholic Acid; D002108:Ceruletide; D000681:Amylases