A comparison of the predictive value and diagnostic efficiency of FHAP and CEA as cancer markers.
Previous studies have shown that fast homoarginine-sensitive alkaline phosphatase (FHAP) is roughly equivalent to CEA (Roche) as a marker in colon cancer. The present study compares FHAP with CEA-EIA (Abbott) as a marker in cancer of the colon, breast, lung, ovary, uterus, skin, and lymph nodes. Comparison is made with regard to sensitivity, specificity, predictive value of a positive test, and diagnostic efficiency. It was determined that FHAP and CEA-EIA were comparable as markers for cancers of the colon, breast, and lung. FHAP was more sensitive and specific and had a higher predictive value and diagnostic efficiency for cancers of the ovary, uterus, skin, and lymph nodes.
D000469:Alkaline Phosphatase / Q000097:blood*; D001120:Arginine / Q000031:analogs & derivatives*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005189:False Positive Reactions; D006709:Homoarginine / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*
D002272:Carcinoembryonic Antigen; D006709:Homoarginine; D001120:Arginine; D000469:Alkaline Phosphatase