title: [Effect of colloid volume replacement substances and Ringer's lactate on hemodynamics and oxygen consumption of intensive care patients].
abstract: Comparison of the effects of various volume substitutes on hemodynamics and oxygen transport variables in critically ill patients. A computerized monitoring system was used to register the hemodynamic effects of lactated ringers solution, human albumin 5%, human albumin 20%, hydroxyethylstarch 6% (Plasmasteril, Fresenius, Oberursel) and hydroxyethylstarch 10% (HAES-Steril, Fresenius, Oberursel) in 25 patients who required invasive monitoring during ICU treatment. In periods of relative volume deficits as documented by a wedge pressure of 11-13 mm of mercury the various substitutes were administered until the wedge pressure reached 15-17 mm of mercury. Comparison of 221 therapeutic interventions demonstrate: Hemydynamic and oxygen transport variables were improved in all colloid trials whereas lactated ringers solution did not improve the patients cardiopulmonary condition. In contrary pulmonary vascular resistance was significantly increased when Ringer's solution was administered. While all colloids produced improvements in the patients hemodynamic and oxygen transport condition, statistically significant improvements could be demonstrated only during infusion of hes 10%.
mesh_terms: D001810:Blood Volume / Q000187:drug effects; D003422:Critical Care; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D000077325:Ringer's Lactate; D012709:Serum Albumin / Q000008:administration & dosage*; D013213:Starch / Q000031:analogs & derivatives*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012709:Serum Albumin; D013213:Starch; D010100:Oxygen
vernacular_title: Die Wirkung von kolloidalen Volumenersatzmitteln und Ringer-Laktat auf Hämodynamik und Sauerstoffverbrauch von Intensivpatienten.