Signal for attachment of a phospholipid membrane anchor in decay accelerating factor.
Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. This approach provides a novel means of targeting proteins to the cell-surface membrane.
D000818:Animals; D018958:CD55 Antigens; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D004247:DNA / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D014162:Transfection
D018958:CD55 Antigens; D008563:Membrane Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D004247:DNA