A new antitumor antibiotic, chounghwamycin A. I. Taxonomy, isolation and characterization.
Chounghwamycin A, a new antitumor antibiotic produced by a strain of Streptomyces sp. No. PL-D-5, was isolated and characterized. It appeared to belong to the actinomycin group of antibiotics from physico-chemical studies and has an empirical formula of C63H88N11O21. The antibiotic is extractable into an organic solvent from the fermentation broth, possessing potent antileukemic activity against P388 mouse leukemia in mice and antimicrobial activity against Gram-positive bacteria with MIC values about 0.1-0.4 microgram/ml, but showed no activity on Gram-negative bacteria, yeast and fungi tested.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D003470:Culture Media; D003609:Dactinomycin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013302:Streptomyces / Q000254:growth & development / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; C049845:chounghwamycin A; D003609:Dactinomycin