[Comparative study of the antibody concentration and protective activity against Pseudomonas aeruginosa of gamma-globulin and IgM-enriched immunoglobulin preparations].
The protective effect of IgM-enriched immunoglobulin isolated by the caprylate-alcohol technique has been found to be more pronounced in comparison with that of the commercial preparation of gamma globulin in experiments on mice infected with P. aeruginosa live culture. The effectiveness of this protective action correlates with a higher content of antibodies to P. aeruginosa O-antigen in IgM-enriched immunoglobulin. In mice injected with P. aeruginosa toxin both preparations have shown equal intensity of their protective action.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D007116:Immunization, Passive; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000032:analysis* / Q000276:immunology / Q000627:therapeutic use; D051379:Mice; D019081:O Antigens; D011552:Pseudomonas Infections / Q000401:mortality / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D005719:gamma-Globulins / Q000032:analysis* / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007075:Immunoglobulin M; D019081:O Antigens; D005719:gamma-Globulins
Sravnitel'noe izuchenie kontsentratsii antitel i protektivnoĭ aktivnosti k Pseudomonas aeruginosa preparatov gamma-globulina i immunoglobulina, obogashchennogo IgM.