Calcium channels and histamine release from mast cells.
Using isolated peritoneal mast cells from two types of genetically different rats, histamine release induced by allergic stimuli was inhibited, in all cases except one, by significantly lower concentrations of an intracellular calcium antagonist than those required to inhibit release induced by a calcium ionophore. The exception related to inhibition of histamine release induced by clinical dextran in NR rats (which are relatively less sensitive to dextran than are control rats) as the concentrations required were of a similar order as those needed to inhibit release by ionophores. The data further support the suggestion that there are different calcium channels involved in the different release processes.
D000818:Animals; D006636:Histamine Release; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D007473:Ion Channels