Correspondence between biochemical and antigenic activity of a 60 kilodalton oncofetal protein during carcinogenesis and tumorigenesis.
Biochemical and immunochemical (ELISA) assays were used concurrently to monitor the rat plasma concentration of a recently identified 60 kDa oncofetal protein. Both the biochemical and antigenic activities increased and decreased in parallel during the growth and after surgical removal, respectively, of a solitary transplantable tumor. These activities also responded similarly in response to the specific induction of the 60 kDa factor in the rat by chemical carcinogens. The data indicate that both assays give similar results and provide further evidence for the specificity of the 60 kDa factor as a marker for carcinogenesis and tumorigenesis.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D001798:Blood Proteins / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000951:Antigens, Neoplasm; D001798:Blood Proteins; D002273:Carcinogens; D009363:Neoplasm Proteins; C031192:oncofetal antigens; D012313:RNA