Cell populations in pagetoid reticulosis: an immunological study using cell activation associated monoclonal antibodies.
The nature of the epidermal cellular infiltrate in pagetoid reticulosis is still subject to intense controversies. Using a panel of recently developed monoclonal antibodies against cell activation and proliferation associated antigens it was possible to demonstrate the activated state of numerous T cells within the lesional epidermis. Moreover approximately 10% of these T cells reacted with proliferation associated antigens. In addition macrophages and Langerhans' cells were found to represent a regular constituent of the epidermal infiltrate with a density clearly exceeding that of unaffected adjacent epidermis. The close apposition of activated T cells and monocytic cells suggests an intensive interaction of both cell types in the development of the pagetoid reticulosis lesion.
D000328:Adult; D000911:Antibodies, Monoclonal; D001706:Biopsy; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000145:classification
D000911:Antibodies, Monoclonal