Alpha 2U-globulin: measurement in rat kidney and relationship to hyaline droplets.
The concentration of renal alpha 2U-globulin increased in a dose-dependent manner in adult male but not female rats which received a single dose of 2,2,4-trimethylpentane (TMP). After administration of a single dose of 12 mmol TMP/kg to adult male rats, the renal concentration of alpha 2U-globulin reached a peak at 48 hours and returned to near background level after 7 days. These changes in renal alpha 2U-globulin concentration were closely paralleled by changes in renal hyaline droplet formation. Renal alpha 2U-globulin and hyaline droplets were absent in normal pre-puberty male rats, and neither could be stimulated by a single dose of TMP. alpha 2U-Globulin was localised in the renal cortex of adult male rats, in particular the S2 segment of the proximal tubule. A greater staining intensity due to alpha 2U-globulin was seen in the S2 and adjacent segments after a single dose of TMP. A strong association is suggested between the presence of renal hyaline droplets and the occurrence of alpha 2U-globulin.
D000510:Alpha-Globulins / Q000378:metabolism*; D000818:Animals; D005260:Female; D006651:Histocytochemistry; D006818:Hyalin / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009795:Octanes; D051381:Rats; D012737:Sex Factors
D000510:Alpha-Globulins; D009795:Octanes; C013803:alpha 2u globulin; C045798:2,2,4-trimethylpentane