Capsaicin-sensitive mechanisms and experimentally induced duodenal ulcers in rats.
The incidence and degree of cysteamine- or dulcerozine-induced duodenal ulcers are increased by systemic capsaicin desensitization (50 mg kg-1 s.c. 4 days before) in adult rats. Acute administration of capsaicin, but not neurokinins or CGRP, produced a small but distinct plasma extravasation (Evans blue leakage) in the rat proximal duodenum which was absent in capsaicin-pretreated rats. These findings indicate the existence of a capsaicin-sensitive 'duodenal defence mechanism' in rats.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D003543:Cysteamine / Q000633:toxicity; D004381:Duodenal Ulcer / Q000139:chemically induced*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D011743:Pyrimidines / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology
D011743:Pyrimidines; C043452:dulcerozine; D013373:Substance P; D003543:Cysteamine; D002211:Capsaicin