[Proteinase inhibitors of the blood plasma in the early period of the development of acute radiation sickness in monkeys].
A study was made of the postirradiation kinetics of blood antiproteinase activity in monkeys (Macaca nemestrina). Whole-body uniform gamma-irradiation (LD100/45) was shown to induce a significant decrease in the activity of alpha 2-macroglobulin during the first 24 h following irradiation: the decreased activity level was retained throughout the entire latent period of radiation sickness. At the height of radiation sickness (the 7th-10th day) up to the animals' death, a sharp increase was registered in the activity of alpha 1-inhibitor of blood plasma proteinases. The authors discuss a pathogenetic role of the diminution of the inhibitory potential of blood in the course of radiation sickness.
D000208:Acute Disease; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000528:radiation effects; D005720:Gamma Rays; D008254:Macaca nemestrina; D008297:Male; D011480:Protease Inhibitors / Q000097:blood* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000201:enzymology* / Q000209:etiology; D013997:Time Factors; D014916:Whole-Body Irradiation; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins / Q000032:analysis / Q000528:radiation effects
D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins
Ingibitory proteinaz plazmy krovi v ranniĭ period razvitiia ostroĭ luchevoĭ bolezni u obez'ian.