Relationships between DNA and protein polymorphisms of apolipoprotein B.
The associations between four restriction fragment length polymorphisms (RFLPs) of the gene for human apolipoprotein B (apo B) and five antigen group (Ag) protein-polymorphisms of apo B have been investigated in 24 unrelated Finnish individuals. In this sample a complete correlation exists between the EcoRI RFLP and the Ag(t/z) polymorphism. There is strong association between the alleles of the XbaI RFLP and Ag(c/g) and a weaker one of the same XbaI site with Ag(x/y). Linkage disequilibrium is observed between the PvuII RFLP and the Ag(a1/d) polymorphism. These associations confirm that the Ag variants are true protein sequence polymorphisms of apo B.
D001055:Apolipoproteins B / Q000235:genetics* / Q000276:immunology; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI; D000939:Epitopes / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D001055:Apolipoproteins B; D000939:Epitopes; D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI