[Histamine receptor-bearing lymphocytes. VI. Influence of histamine on the Go-G1 transition of activated lymphocytes].
Histamine (10(-4) M) suppressed the PHA-induced activation of lymphocytes in vitro. This was shown by inhibition of the expression of DR- and 4F2-antigens, of the blast transformation, DNA- and RNA-synthesis, and the formation of thermostable sheep erythrocyte rosettes. Histamine affect these phenomenons only when added to the culture during the first hours. Already 6 hrs after addition of PHA, it exerted no significant suppression. The target of the inhibiting effect of histamine is the G0-G1-transition of the lymphocytes. Cells that already had entered the G1-phase were no more susceptible to histamine.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology; D002453:Cell Cycle; D002454:Cell Differentiation / Q000187:drug effects; D004912:Erythrocytes / Q000502:physiology; D006684:HLA-DR Antigens; D006632:Histamine / Q000276:immunology / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D016169:Lymphocyte Function-Associated Antigen-1; D008214:Lymphocytes / Q000166:cytology / Q000648:ultrastructure*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D012397:Rosette Formation / Q000379:methods; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
D000954:Antigens, Surface; D006684:HLA-DR Antigens; D006633:Histamine Antagonists; D000949:Histocompatibility Antigens Class II; D016169:Lymphocyte Function-Associated Antigen-1; D010835:Phytohemagglutinins; D012313:RNA; D006632:Histamine
Histaminrezeptor-tragende Lymphozyten. VI. Einfluss von Histamin auf den G0-G1-Ubergang von aktivierten Lymphozyten.