Salivary concentrations of pirmenol as a possible cause of unpleasant taste.
Salivary concentrations of the anti-arrhythmic, pirmenol, were compared with plasma concentrations in six patients. Group mean salivary values tended to be higher despite high plasma protein binding, suggesting the possibility of an active transport process. The observed salivary concentrations are reasonably close to those detectable in healthy volunteers as tasting unpleasant.
D000328:Adult; D000368:Aged; D001692:Biological Transport; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000378:metabolism* / Q000627:therapeutic use; D011897:Random Allocation; D012463:Saliva / Q000032:analysis*; D013649:Taste
D010880:Piperidines; C024318:pirmenol