Role of interferon, antibodies and macrophages in the protective effect of Corynebacterium parvum on encephalomyocarditis virus-induced disease in mice.
Treatment of mice with Corynebacterium parvum enhances their resistance to encephalomyocarditis (EMC) virus infection. In EMC-virus-infected mice, pretreated with C. parvum, neither interferon production nor antibody responses were increased. A decrease of virus recovery was observed in cultures of macrophages taken from the peritoneum of mice early after injection of C. parvum and infected with EMC-virus in vitro. The data suggest that C. parvum acts by increasing intrinsic antiviral activity of macrophages.
D000818:Animals; D000917:Antibody Formation; D004686:Encephalomyocarditis virus / Q000276:immunology; D004769:Enterovirus Infections / Q000276:immunology*; D005260:Female; D007372:Interferons / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D011425:Propionibacterium acnes / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms
D007372:Interferons