Nasopharyngeal carcinoma: a review of cases treated by radiotherapy and chemotherapy.
Between 1965 and 1983, 52 cases of carcinoma of the nasopharynx were treated with radiotherapy alone and 14 treated with combination chemotherapy containing cisplatin followed by a radical course of radiation. Before 1981 all cases were treated by radiotherapy alone with a variety of dose and fractionation regimes. The actuarial overall 3 year survival for these cases was 35%. Twelve of the 14 (86%) who received chemotherapy responded, and in two there was complete disappearance of disease before the radiotherapy. The 3 year survival for those receiving chemotherapy and radiotherapy was 86%. The possible reasons for this apparent improvement are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*
D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil