title: Brain-stem monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patients.
abstract: Preterminal BAEP changes were studied until brain death in 8 head-injured patients out of a series of 38 comas monitored by means of a system allowing high-rate sequential recording. Two different modalities of BAEP degradation were disclosed: (1) simultaneous latency increase of all components associated with a decrease of cerebral perfusion pressure (CPP), consistent with ongoing ischaemia of the posterior fossa; (2) deterioration of brain-stem components (waves III-V) with preserved or even enhanced wave I. The latter pattern was not consistently associated with any haemodynamic change and might be related to mechanical factors causing rostro-caudal deterioration of brain-stem function. The time course of BAEP degradation ranged from a few minutes to more than 10 h. In the case of slow preterminal evolution definitely pathological trends were identified even when individual BAEPs were still within normal limits. Such trends would have remained unnoticed in single BAEP records. Hypothermia and anaesthetic drugs were found to induce falsely alarming BAEP changes very similar to those seen during preterminal evolution. Our results suggest that continuous brain-stem monitoring could be helpful for management of comatose head-injured patients.
mesh_terms: D001794:Blood Pressure; D001831:Body Temperature; D001926:Brain Death; D001933:Brain Stem / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003128:Coma / Q000503:physiopathology*; D003626:Data Display; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007362:Intensive Care Units; D007427:Intracranial Pressure; D008012:Lidocaine / Q000627:therapeutic use; D008722:Methods; D008991:Monitoring, Physiologic; D013874:Thiopental / Q000097:blood / Q000627:therapeutic use
chemical_list: D008012:Lidocaine; D013874:Thiopental