The effect of DNA hypomethylating agents on the reactivation of herpes simplex virus from latently infected mouse ganglia in vitro. Brief report.
Effects of DNA hypomethylating agents on reactivation of herpes simplex virus from latently infected mouse ganglia in vitro were examined. L-ethionine and 5-azacytidine increased the incidence of reactivation. Dimethylsulphoxide and 5-azacytidine allowed earlier detection of virus.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D004279:DNA, Viral / Q000235:genetics*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005728:Ganglia, Sympathetic / Q000382:microbiology* / Q000502:physiology; D006561:Herpes Simplex / Q000235:genetics*; D066298:In Vitro Techniques; D008745:Methylation; D051379:Mice; D018139:Simplexvirus / Q000235:genetics* / Q000254:growth & development; D014709:Vero Cells; D014779:Virus Replication
D004279:DNA, Viral; D001374:Azacitidine; D004121:Dimethyl Sulfoxide