title: A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies.
abstract: The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of which was blocked by antibody to the 16/6 ID. Our studies reveal that 16/6 ID is present on two antibodies with different binding specificities.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology*; D003429:Cross Reactions; D004277:DNA, Single-Stranded / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000961:Antilymphocyte Serum; D004277:DNA, Single-Stranded; D000939:Epitopes; D007130:Immunoglobulin Idiotypes