Axoplasmic transport of monoamine oxidase after ischemia.
Rabbit spinal cords were subjected to 40 min of ischemia by abdominal aorta occlusion followed by 1 or 4 days of recirculation. Axoplasmic transport of mitochondria was investigated by monitoring the accumulation of monoamine oxidase activity (MAO, EC 1.4.3.4) at the proximal and distal ligatures placed on sciatic nerves. Within 1 day following ischemia, MAO accumulation was reduced to 45% and 34% at the proximal and distal ties, respectively. Within 4 days after ischemia, MAO accumulation was depressed still further to 22% in either direction. The substantial decrease in transport velocity appears to be the immediate cause for the observed decrease in MAO accumulation in sciatic nerve.
D000818:Animals; D001370:Axonal Transport; D005260:Female; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D011817:Rabbits; D012584:Sciatic Nerve / Q000201:enzymology; D013116:Spinal Cord / Q000098:blood supply*
D008995:Monoamine Oxidase