Common properties shared by growth-associated proteins of the regenerating optic nerve of goldfish (C. auratus).
Regenerating neurons synthesize new, rapidly transported, growth-associated proteins which are thought to mediate the regeneration process. We have studied these proteins in the regenerating optic nerves of goldfish by using two-dimensional polyacrylamide gel electrophoresis coupled with gel fluorography and computer analysis. The results indicate that goldfish retinal ganglion cells produce 3 polypeptides which qualify as growth-associated proteins. Properties shared by each of these 3 polypeptides suggest that they may originate from a common precursor.
D000818:Animals; D001370:Axonal Transport; D004591:Electrophoresis, Polyacrylamide Gel; D006054:Goldfish; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology; D008970:Molecular Weight; D009416:Nerve Regeneration; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors
D006133:Growth Substances