Reduced levels of histidine and urocanic acid in suction blister fluids from patients with psoriasis.
Metabolites of histidine were determined by high performance liquid chromatography in suction blister fluids from lesions and normal appearing skin of patients with psoriasis and from healthy subjects. There was a significant decrease in the levels of histidine and urocanic acid in the samples obtained from patients with psoriasis as compared to healthy subjects. Virtually only the E-isomer of urocanic acid was detected.
D000328:Adult; D000368:Aged; D001768:Blister / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006639:Histidine / Q000032:analysis*; D006801:Humans; D007093:Imidazoles / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism* / Q000532:radiotherapy; D012867:Skin / Q000378:metabolism*; D014467:Ultraviolet Therapy; D014560:Urocanic Acid / Q000032:analysis*
D007093:Imidazoles; D006639:Histidine; D014560:Urocanic Acid