[Effect of verapamil and nifedipine on the adhesion, migration and phagocytosis of human neutrophilic granulocytes].
The calcium antagonists Verapamil and Nifedipin have a different effect on adherence, migration and phagocytosis of human neutrophilic granulocytes. Whereas Verapamil (10(-4) mol/1) will inhibit the leukocyte function, Nifedipin is ineffective. The leukocyte function cannot be expected to be impaired by using Nifedipin and Verapamil in therapeutic doses. The differences in efficiency and their possible causes are discussed.
D000328:Adult; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects*; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D009543:Nifedipine / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D007473:Ion Channels; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium
Die Wirkung von Verapamil und Nifedipin auf Adhärenz, Migration und Phagozytoseverhalten neutrophiler Granulozyten des Menschen.