A muscarine-resistant M-current in C cells of bullfrog sympathetic ganglia.
C cells of bullfrog sympathetic ganglia have an M-current similar to that of the larger B cells. However, the M-current of C cells is much less sensitive to muscarinic agonists. The M-current of C cells is blocked by barium and by LHRH (mammalian luteinizing hormone-releasing hormone). LHRH sometimes also decreases a different conductance, with an extrapolated reversal potential near 0 mV. These results demonstrate that the coupling of receptors to ion channels can vary between cell types, even within a single ganglion.
D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D009116:Muscarine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D011892:Rana catesbeiana; D011976:Receptors, Muscarinic / Q000502:physiology*
D007473:Ion Channels; D011976:Receptors, Muscarinic; D007987:Gonadotropin-Releasing Hormone; D009116:Muscarine; D011188:Potassium