[Allergic encephalomyelitis in guinea pigs on the intracutaneous and subcutaneous administration of fragment 114-122 of the human myelin cationic protein].
Single intracutaneous injection of 30 micrograms of human basic myelin protein peptide 114-122 (H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH) with Freund adjuvant induced the onset of encephalomyelitis on day 9-19 after the injection. The lethality was 33%. In autumn the disease was more severe than in summer.
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced* / Q000401:mortality; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008297:Male; D004676:Myelin Basic Protein / Q000008:administration & dosage*; D010446:Peptide Fragments / Q000008:administration & dosage*; D012621:Seasons; D013997:Time Factors
D004676:Myelin Basic Protein; D010446:Peptide Fragments; C050978:myelin basic protein 114-122; D005620:Freund's Adjuvant
Allergicheskiĭ éntsefalomielit u morskikh svinok pri vnutrikozhnom i podkozhnom vvedenii fragmenta 114-122 kationnogo belka mielina cheloveka.