title: A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.
abstract: A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D046911:Macromolecular Substances; D012313:RNA / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology
chemical_list: D004274:DNA, Recombinant; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D012313:RNA; D004247:DNA