The actions of avermectin on crayfish nerve and muscle.
Avermectin is a potent anthelmintic, insecticide and acaricide, which is thought to act by opening GABA (gamma-amino butyric acid)-mediated chloride channels. The effects of avermectin on a crayfish nerve cell (stretch receptor neuron) were compared with those on a muscle (dactyl abductor). Concentrations above 10(-7) M caused a conductance increase and a slight reduction in GABA sensitivity in both nerve and muscle. Lower concentrations potentiated the effect of GABA in muscle, but not in the nerve cell.
D000818:Animals; D003400:Astacoidea; D002712:Chlorides / Q000378:metabolism; D004594:Electrophysiology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000633:toxicity; D008465:Mechanoreceptors / Q000187:drug effects* / Q000502:physiology; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002712:Chlorides; D007473:Ion Channels; D005680:gamma-Aminobutyric Acid; D007559:Ivermectin; C019264:avermectin