Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain.
We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology*; D000679:Amygdala / Q000201:enzymology; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006624:Hippocampus / Q000201:enzymology; D006801:Humans; D009478:Neuropeptide Y / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
D009478:Neuropeptide Y; D013373:Substance P; D013004:Somatostatin; D002795:Choline O-Acetyltransferase