[The monoclonal gammapathy of uncertain meaning- a premyelomatosis?].
In three cases of localised multiple myeloma the monoclonal immunoglobulin could be identified even 17, 12 and 8 years prior to clinical manifestation. These observations point again to the question of a possible "history of development" for the plasma cell disease and, thus, to the clinical validity of monoclonal gammopathy of (still) uncertain significance. As even in the relationship of membrane-associated light chains of B-lymphocytes a certain monoclonality begins to appear at an early time, more attention should be devoted to the early diagnosis of malign plasma cell dyscrasia.
D000368:Aged; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis*; D010265:Paraproteinemias / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis*
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains
Die monoklonale Gammopathie unbestimmter Bedeutung--eine Prämyelomatose?