Age-related sensitivity of rats to induction of anaemia.
The intensity of symptoms of experimental anaemia significantly depended on the age of animals. It increased in elder rats after administration of substances with haemolytic potential (phenylhydrazine, phenacetin, 3-chloro-4-benzyloxyphenylacetic acid, nitrobenzene) whereas it decreased after cyclophosphamide-induced erythropoietic suppression.
D000367:Age Factors; D000740:Anemia / Q000097:blood / Q000139:chemically induced*; D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D009578:Nitrobenzenes / Q000009:adverse effects; D010615:Phenacetin / Q000009:adverse effects; D010648:Phenylacetates / Q000009:adverse effects; D010659:Phenylhydrazines / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes; D012307:Risk Factors
D006454:Hemoglobins; D009578:Nitrobenzenes; D010648:Phenylacetates; D010659:Phenylhydrazines; C030299:phenylhydrazine; C023677:3-chloro-4-benzoyloxyphenylacetic acid; D003520:Cyclophosphamide; C036077:nitrobenzene; D010615:Phenacetin