Effect of ammonia on cyclic AMP production in primary astrocyte cultures.
Exposure of primary astrocyte cultures to ammonia caused a dose- and time-dependent reduction of isoproterenol-stimulated cyclic AMP (cAMP) production. This treatment did not affect basal cAMP levels. This defect in receptor-linked cAMP production may contribute to the pathogenesis of hepatic and ammonia encephalopathies.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000641:Ammonia / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis*; D006501:Hepatic Encephalopathy / Q000209:etiology; D007545:Isoproterenol / Q000494:pharmacology; D051381:Rats
D000641:Ammonia; D000242:Cyclic AMP; D007545:Isoproterenol; D015056:1-Methyl-3-isobutylxanthine