Immunohistochemistry in neuro-oncology.
The technical modalities of the immunohistochemical demonstration of antigens of neuroectodermal differentiation and of mesenchymal nature in neural tissue are discussed. On the main antigens (S-100 protein, GFAP, Vimentin, Neuronal specific Enolase, neurofilaments, myelin basic protein, carboanhydrase C, FVIII/RAg, laminin, fibronectin) the most important findings are described and critically considered. They are interpreted in the light of the present knowledge on the problems of differentiation of the oncotypes and on particular aspects of bio-pathology of brain tumors.
D001253:Astrocytes / Q000032:analysis; D005404:Fixatives; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005910:Glioma / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007797:Laminin / Q000032:analysis; D008527:Medulloblastoma / Q000032:analysis; D004676:Myelin Basic Protein / Q000032:analysis; D009283:Naphthol AS D Esterase; D009380:Neoplasms, Nerve Tissue / Q000032:analysis* / Q000473:pathology; D013194:Staining and Labeling; D014446:Tyrosine 3-Monooxygenase; D014746:Vimentin / Q000032:analysis; D004124:p-Dimethylaminoazobenzene
D005404:Fixatives; D005904:Glial Fibrillary Acidic Protein; D007797:Laminin; D004676:Myelin Basic Protein; D014746:Vimentin; D004124:p-Dimethylaminoazobenzene; D014446:Tyrosine 3-Monooxygenase; D009283:Naphthol AS D Esterase