[Experimental study of the protective activity of vaccines made from 7 Pseudomonas aeruginosa immunotypes].
Monovaccines were prepared from seven P. aeruginosa immunotypes (according to Fisher's classification) and three P. aeruginosa production strains belonging to immunotypes 2, 3, and 7. The immunogenic potency of these monovaccines was studied in direct and cross experiments on the active protection of mice. The study revealed that the monovaccines prepared from P. aeruginosa of seven immunotypes possessed both specific and cross protective activity. Protective cross activity was revealed also in the vaccines prepared from the production strains. When tested in mice challenged with the corresponding homologous strains, the monovaccines prepared from immunotypes 2, 3, 4 and 7 proved to possess higher immunogenic potency than monovaccines prepared from immunotypes 1, 5 and 6.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology*; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012703:Serotyping; D013997:Time Factors
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D000939:Epitopes
Eksperimental'noe izuchenie protektivnoĭ aktivnosti vaktsin iz semi immunotipov Pseudomonas aeruginosa.