Recovery of synaptic transmission predicted from extracellular K+ undershoots following brief anoxia in hippocampal slices.
In rat hippocampal slices exposed to short duration anoxia, recovery of synaptic transmission was dependent upon the magnitude of the K+o undershoot (K+o drop below resting level) seen following return to normoxic conditions. Because the K+o undershoot is likely to be related to ion pump activity, our results imply that recovery of brain from stroke depends upon how well ion transport and energy production recover.
D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D006624:Hippocampus / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007473:Ion Channels / Q000502:physiology; D008297:Male; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D007473:Ion Channels; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium