Inhibitory effect of tritoqualine on activation of latent polymorphonuclear leukocyte collagenase.
Treatment of rats with histamine releaser compound 48/80 caused changes in blood leukocyte populations. An increased number of PMN-leukocytes was observed. Tritoqualine only modestly reduced the number of granulocytes. In animals treated with compound 48/80 an activation of PMN-leukocyte latent collagenase of up to 80% was observed. This activation was partially inhibited (about 40%) in animals pretreated with tritoqualine. The results presented suggest that the beneficial effect of tritoqualine in allergic diseases may be in part connected with an indirect inhibition of collagenase activity.
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D007546:Isoquinolines / Q000494:pharmacology*; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D007546:Isoquinolines; D003189:p-Methoxy-N-methylphenethylamine; D003012:Microbial Collagenase; C003722:tritoqualine