Are acquired nevi oestrogen-dependent tumours?
Twelve benign acquired nevi were studied for the possible specific binding of the ER D5 monoclonal antibody. The ER D5 monoclonal antibody identifies the p29 protein, which is found in the cytoplasm of oestrogen-sensitive cells and which is present in a higher concentration than nuclear oestrogen receptors. No staining was seen in nevoid cells, and the results are taken to support the hypothesis that acquired nevi are not oestrogen-dependent tumours.
D000328:Adult; D000911:Antibodies, Monoclonal; D004967:Estrogens; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis*; D009506:Nevus / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis*
D000911:Antibodies, Monoclonal; D004967:Estrogens; D011506:Proteins