Hamartoma of the parotid gland: a case report with immunohistochemical and electron microscopic study.
A case of a solid parotid tumour in a 16-year-old boy is presented. Histologically, the tumour demonstrated some peculiar findings. An acinar pattern was predominant although every component seen in the normal salivary gland was present, namely, serous and mucous gland acini, ducts, myoepithelial cells, adipose and lymphoid tissue. Large eosinophilic granules were abundant in the large acinar cell cytoplasm. Immunohistochemically, the tumour demonstrated the proteins which are present in the normal parotid gland, for example, amylase, lactoferrin and lysozyme. Electron microscopic features were quite similar to those of normal parotid tissue except for accumulation of a large number of cytoplasmic granules in the acinar cells. There has been no previous report of a tumour with the same features as seen in this case. Our pathological diagnosis is hamartoma, although the possibility of hyperplasia or neoplasia can not be excluded.
D000293:Adolescent; D000681:Amylases / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007781:Lactoferrin / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D009113:Muramidase / Q000378:metabolism; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology*
D000681:Amylases; D009113:Muramidase; D007781:Lactoferrin