[Immunochemical and physico-chemical characteristics of glycoprotein from retroplacental blood having several common antigenic determinants with trophoblastic beta 1-glycoprotein].
A glycoprotein (TSG-fs) isolated from retroplacental blood is shown to have common antigenic determinants with trophoblast-specific beta 1-glycoprotein (TSG, SP-1). Antigenic activity of TSG-fs constitute 3.4% of TSG's activity. Like TSG, glycoprotein TSG-fs contains four intramolecular disulfide bonds and belongs to proteins with predominantly beta-structure. CD-spectroscopy data give evidence of high stability of the secondary structure of TSG-fs. Immunochemical identity of TSG-fs with the reduced and carboxymethylated derivative of TSG has been demonstrated. The above data allow to suggest that TSG-fs is a fragment of the TSG molecule.
D000596:Amino Acids / Q000032:analysis; D001769:Blood; D002942:Circular Dichroism; D000939:Epitopes / Q000032:analysis*; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007124:Immunoenzyme Techniques; D009005:Monosaccharides / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis* / Q000276:immunology; D010920:Placenta; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis* / Q000276:immunology; D011487:Protein Conformation; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000939:Epitopes; D009005:Monosaccharides; D010446:Peptide Fragments; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins
Immunokhimicheskaia i fiziko-khimicheskaia kharakteristika glikoproteina iz retroplatsentarnoĭ krovi, imeiushchego riad obshchikh antigennykh determinant s trofoblasticheskim beta 1-glikoproteinom.