Stimulatory effect of substance P on sympathetic ganglia and spinal cord in culture.
Studies with organotypic culture of sympathetic ganglia and spinal cord revealed that substance P at concentrations of 10(-5) to 10(-12) M and 10(-5) to 10(-14) M exerts a marked growth-stimulating effect on sympathetic ganglia and spinal cord, respectively. In the presence of substance P, the intensity of sympathetic ganglion growth exceeds control values 3.0-4.8 times. The growth zone size of spinal cord explants increases under these conditions 2.0-5.2-fold. A feasible physiological significance of regulatory peptides in the growth and regeneration of nervous tissue as well as the role of noci-antinociceptive systems in histogenesis and regeneration are discussed.
D000818:Animals; D002478:Cells, Cultured; D003712:Dendrites / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000166:cytology* / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P