Immunohistochemical detection of c-myc oncogene product in human gastric carcinomas: expression in tumor cells and stromal cells.
c-myc protein p62 in human gastric carcinomas was studied by immunohistochemistry using an antiserum raised against the C-terminal portion of the human c-myc gene protein. No immunoreactivity of c-myc p62 was detected in tumor cells of 27 early carcinomas, while c-myc p62-positive tumor cells were observed in 51 (36.4%) of the 140 advanced carcinomas. Many stromal cells including macrophages and fibroblasts around the tumors showed various degrees of c-myc p62 immunoreactivity. Localization of c-myc p62 was predominant in the cytoplasm of tumor cells and stromal cells. The prognosis of patients with p62-positive stromal cells was significantly better than that of patients with p62-negative stromal cells.
D004815:Epidermal Growth Factor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007372:Interferons / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016271:Proto-Oncogene Proteins c-myc; D013270:Stomach / Q000032:analysis*; D013274:Stomach Neoplasms / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D004815:Epidermal Growth Factor; D007372:Interferons; D013755:Tetradecanoylphorbol Acetate