[Sensitivity of antineoplastic agents in squamous cell carcinoma of the uterine cervix xenografted into nude mice].
Antitumor efficacies of five antineoplastic agents, cisplatin, mitomycin, doxorubicin, 5-fluorouracil and bleomycin were tested against the human carcinoma of the uterine cervix xenografted into nude mice in order to search for effective combination chemotherapy. Antineoplastic agent was administered i.p. 6 times once a week to nude mice with tumor growing to 8-10 mm in diameter. The effect in each group was evaluated by Battelle Columbus Laboratories' method, measuring at 6th week the tumor growth rate in the treatment group (Tn/T0) and in the control group (Cn/C0) where the comparative tumor growth ratio (Tn/T0/Cn/C0) was taken as the index. As the result, the response rates of cisplatin and mitomycin on the tumor growth were high as 83.3% and 66.7% respectively. It is concluded that combination chemotherapy including cisplatin and mitomycin is recommendable for the treatment of squamous cell carcinoma of the uterine cervix.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002945:Cisplatin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009368:Neoplasm Transplantation; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D000970:Antineoplastic Agents; D008937:Mitomycins; D001761:Bleomycin; D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil