Effect of the new specific bradycardia agent AQ-A39 (falipamil) on coronary collateral blood flow in dogs.
The effect of two doses (0.5 and 1.0 mg/kg i.v.) of a new specific bradycardic agent, AQ-A39 (5,6-dimethoxy-2-[3- [( alpha- (3,4,-dimethoxy)phenylethyl]methyl-amino)propyl]phthalimidine hydrochloride), on three indices of collateral function--retrograde pressure, retrograde flow, and tissue blood flow (radioactive microspheres)--was studied in anesthetized dogs following acute occlusion of the left anterior descending coronary artery. AQ-A39 produced a significant (p less than 0.05) dose-related decrease in heart rate without any other hemodynamic changes. Retrograde flow and subendocardial blood flow were significantly increased by the lower dose of AQ-A39, whereas retrograde pressure, retrograde flow, and midmyocardial and subendocardial flow were increased by the higher dose. Atrial pacing to the control heart rate eliminated the beneficial effects of AQ-A39 on collateral function. These results suggest that an increase in collateral perfusion may be one mechanism by which AQ-A39 alleviates myocardial ischemia.
D000818:Animals; D001919:Bradycardia / Q000139:chemically induced*; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D054833:Isoindoles; D008297:Male; D010797:Phthalimides / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D002317:Cardiovascular Agents; D054833:Isoindoles; D010797:Phthalimides; C030532:falipamil