[Can changes in the gonadotropin response in androgen insensitivity syndrome be detected with the GnRH test following gonadectomy and steroid administration?].
Information about the reaction of the hypothalamic pituitary axis by Gn-Rh-stimulation dependent from gonadectomy and steroid substitution in 3 patients with androgen insensitivity syndrome. The test was done before and after gonadectomy, under receipt of within the intake of a sequential hormonal contraceptive (Sequenz-Ovosiston) in the 16th cycle and after a pill free interval of 3 months, LH and FSH were estimated with a RIA-method. The LH-base-concentration is independent from the moment of the gonadectomy normogonadotrop and indicate after Gn-Rh-stimulation a regular LH-answer. The FSH-reaction is clearly dependent from the moment of gonadectomy. Not the gonadectomy but the steroid substitution over a long time is decisive about the reaction of the adenohypophysis.
D000293:Adolescent; D013734:Androgen-Insensitivity Syndrome / Q000097:blood*; D002715:Chlormadinone Acetate / Q000008:administration & dosage; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008656:Mestranol / Q000008:administration & dosage; D009919:Orchiectomy; D010906:Pituitary Hormone-Releasing Hormones; D011183:Postoperative Complications / Q000097:blood*
D003277:Contraceptives, Oral, Combined; D010906:Pituitary Hormone-Releasing Hormones; D002715:Chlormadinone Acetate; C002785:Ovosiston; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008656:Mestranol
Lassen sich mit dem Gn-RH-Test nach Gonadektomie und Steroidapplikation Veränderungen in der Gonadotropinantwort beim Androgen Insensitivity Syndrom nachweisen?