Effects on brain cholecystokinin-8-sulfate and serotonin in adult rats after neonatal reduction of catecholamines.
Depletion of dopamine (DA) in neonatal rats by cerebroventricular infusion of 6-hydroxydopamine with desmethylimipramine resulted in a significant decrease in mesolimbic immunoreactive cholecystokinin-8-sulfate (CCK-8SI) and a marked increase in striatal serotonin in 10-week-old rats. In contrast, neonatal norepinephrine (NE) depletion did not affect either CCK-8SI or serotonin in the frontal cortex, anterior cingulate cortex or hippocampus. Neonatal DA and NE depletion did not induce an increase in striatal serotonin.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D002395:Catecholamines / Q000378:metabolism / Q000502:physiology*; D003891:Desipramine; D006892:Hydroxydopamines; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012844:Sincalide / Q000378:metabolism*
D002395:Catecholamines; D006892:Hydroxydopamines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D016627:Oxidopamine; D012844:Sincalide; D003891:Desipramine