Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG).
Antibody responses to the myelin/oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) were determined in the sera of Hartley guinea pigs with chronic relapsing experimental allergic encephalomyelitis (CREAE) using an enzyme-linked immunoassay. The sera were also tested for in vivo demyelinating activity by infusion into the subarachnoid space of normal rats. In contrast to the MBP titres, the anti-MOG antibody titres showed good correlation with the in vivo demyelinating activity of the sera (r = 0.91, P less than 0.001). This result suggests that antibodies directed against MOG may be involved in the pathogenesis of demyelination in CREAE.
D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000209:etiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006168:Guinea Pigs; D006801:Humans; D004676:Myelin Basic Protein / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology*; D009836:Oligodendroglia / Q000276:immunology*
D001323:Autoantibodies; D006023:Glycoproteins; D004676:Myelin Basic Protein; D009185:Myelin Proteins