[Comparative study of the modification of blood, blood coagulation, cardiovascular circulation by 3% modified, fluid gelatins and 6% low-molecular weight hydroxyethyl starch].
A randomized, comparative study with 3% modified fluid gelatine and 6% low molecular hydroxyethylstarch has been made on 87 patients of an intensive care unit. Both plasma substitutes were well compatible to the patients. The erythrocyte sedimentation rate was accelerated significantly by both plasma substitutes. This effect was at a maximum after 24 h and in the gelatine group it was percental about three times stronger, referred to the base line level in this group. In the hydroxyethylstarch group after 12 h the thrombocyte cell number decreased about 10.3%, referred to the base line, in the gelatine group the decrease was only 1.5% at the same time. At the chemical parameters there were no more differences between the two substitutes. Both plasma substitutes showed a mean effect of 4 h on plasma volume, referred to the changes of central venous pressure. The gelatine substitute showed a significant rise in blood pressure after end of infusion, the hydroxyethylstarch substitute did not. Both substitutes showed a rise in diuresis with a delay of 1 h. There were no differences between both solutions in the diuretic effect after infusion.
D001769:Blood / Q000187:drug effects*; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D005780:Gelatin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D008970:Molecular Weight; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011897:Random Allocation; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D005780:Gelatin; D013213:Starch; C002803:oxypolygelatine
Vergleichende Untersuchung zur Beeinflussung von Blut, Blutgerinnung, Herz und Kreislauf durch 3%ige modifizierte, flüssige Gelatine und 6%ige niedermolekulare Hydroxyäthylstärke.