Modulation of T cells by cyclic AMP in murine influenza virus infection. I. In vitro inhibition of cytotoxic T lymphocytes by exogenous cyclic AMP analogues and by agents which increase intracellular cyclic AMP concentrations.
The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined. Treatment of influenza A/WSN virus primed primary immune spleen cells and their cultured secondary effector T cells from Balb/c mice with these agonists resulted in increases in cyclic AMP levels. These agents also had a marked inhibitory effect on the cytotoxic activity of primary immune spleen cells, but a much weaker inhibitory effect on that of secondary effector T cells. No significant effect of 8-bromo-cyclic GMP on the cytotoxic activity of these two cell types was observed. The cytotoxic activity of H-2-restricted, virus-specific T cells generated either in vivo (primary) or in vitro (secondary) was not significantly inhibited by treatment with histamine, whereas that of alloreactive killer T cells generated in vivo was markedly inhibited. These results suggest that the actions of H-2-restricted, virus-specific T cells may not be regulated by histamine during viral or inflammatory processes.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D015232:Dinoprostone; D006632:Histamine / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects
D011458:Prostaglandins E; D015124:8-Bromo Cyclic Adenosine Monophosphate; D006632:Histamine; D002772:Cholera Toxin; D000242:Cyclic AMP; D015232:Dinoprostone; D015056:1-Methyl-3-isobutylxanthine; D006854:Hydrocortisone