title: Comparison of peptide aldehydes with alpha 1-antitrypsin as elastase inhibitors for use in emphysema.
abstract: The in vitro properties of two peptide aldehydes are described which relate to their potential use as elastase inhibitors in the treatment of emphysema. When compared with alpha 1-antitrypsin they demonstrate potential advantages in terms of potency, specificity and stability to cigarette smoke.
mesh_terms: D000447:Aldehydes / Q000627:therapeutic use*; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D004646:Emphysema / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012907:Smoking; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D000447:Aldehydes; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010196:Pancreatic Elastase