Modelling of the effects of Na+ and Ca2+ ions on the generation of action potentials by rabbit heart true pacemaker cells.
A comparison of results of modelling and physiological experiments allowed to estimate in the first approximation the quantitative contribution of calcium and sodium ions to the generation of different ionic currents determining the shape of the action potential (AP). Generally, the model reproduced adequately variations in AP shape with changes in the external concentrations of Na+ and Ca2+. At the same time the model differs slightly from the experimental results. To improve the model kinetic variables of slow inward current have to be taken into account.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D011817:Rabbits; D012849:Sinoatrial Node / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D012984:Software
D007473:Ion Channels; D012964:Sodium; D002118:Calcium