[Disordered DNA repair in the lymphocytes of patients with schizophrenia depending on the form of the course of the disease].
Employing the appropriate technique the authors have examined lymphocytes of 26 patients suffering from schizophrenia of different types. The study has shown distinct disorders of DNA reparation associated with this disease, which is suggestive of deficiency or noncoordination of the enzymatic system explained by mutations in corresponding genes. Disorders of DNA reparation have until recently been known to be associated only with hereditary diseases.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D005796:Genes / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D008297:Male; D009154:Mutation; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics
D001761:Bleomycin; D015112:4-Nitroquinoline-1-oxide; D004247:DNA
Narushenie reparatsii DNK v limfotsitakh bol'nykh shizofrenieĭ v zavisimosti ot formy techeniia zabolevaniia.