title: Spectra of neurotransmitter receptors and ionic responses on cerebral A and B neurons in Aplysia californica.
abstract: Receptors to putative transmitters on A and B cells of Aplysia californica were identified and characterized. Neurons within each cluster were similar in responses to transmitters, but the neurons in A and B clusters differed. Both exhibited receptors to acetylcholine, dopamine, gamma-aminobutyric acid, glutamate, histamine and serotonin but not to octopamine or phenylethanolamine. Bi- or multiphasic responses to a single transmitter were common on both cell types. Inhibitory responses were more common on A than B cells where glutamate, histamine and serotonin were all excitatory. Each of these clusters appear homogeneous both in terms of presence of receptors and the ionic channels activated by the receptors.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001048:Aplysia; D001224:Aspartic Acid / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005724:Ganglia / Q000166:cytology / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D005971:Glutamates; D007473:Ion Channels; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine