title: Potentiation by levamisole, methisoprinol, and adenine or adenosine of the inhibitory activity of human interferon against encephalomyocarditis virus.
abstract: The antiviral action of different human interferons against encephalomyocarditis virus in HeLa cell cultures was analyzed. Cell treatment with levamisole (200 micrograms/ml), methisoprinol (1 mg/ml), or adenine or adenosine (33 or 100 micrograms/ml, respectively) potentiated the anti-encephalomyocarditis virus activity of human interferon by 8- to 32-fold. A higher level of potentiation (256-fold) was achieved either by combined treatments with levamisole plus methisoprinol or by treatment with one of these compounds plus adenine or adenosine.
mesh_terms: D000225:Adenine / Q000494:pharmacology*; D000241:Adenosine / Q000494:pharmacology*; D004357:Drug Synergism; D004686:Encephalomyocarditis virus / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology*; D007978:Levamisole / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007978:Levamisole; D007288:Inosine; D007372:Interferons; D000225:Adenine; D000241:Adenosine; D007542:Inosine Pranobex