[Differentiation of human malignant myeloid and lymphoid cells].
In vitro differentiation of malignant cells was obtained with various agents such as DMSO, retinoids, and low concentrations of ARA-C. In vivo treatment with low dose ARA-C in acute non-lymphoblastic leukemia, especially in elderly patients, induced complete remissions. Interferon was active in hairy cell leukemia, not through cytotoxic cell activation but by a direct effect on cell growth of the hairy cells and changes in the expression of some genes.
D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003561:Cytarabine / Q000494:pharmacology*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007943:Leukemia, Hairy Cell / Q000473:pathology* / Q000628:therapy; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects*
D003561:Cytarabine; D007372:Interferons
Différenciation de la cellule myéloïde et lymphoïde maligne humaine.