Comparison of peptide aldehydes with alpha 1-antitrypsin as elastase inhibitors for use in emphysema.
The in vitro properties of two peptide aldehydes are described which relate to their potential use as elastase inhibitors in the treatment of emphysema. When compared with alpha 1-antitrypsin they demonstrate potential advantages in terms of potency, specificity and stability to cigarette smoke.
D000447:Aldehydes / Q000627:therapeutic use*; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D004646:Emphysema / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012907:Smoking; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*; D000511:alpha-Macroglobulins / Q000378:metabolism
D000447:Aldehydes; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010196:Pancreatic Elastase