The expression of PNA-lectin binding sites and S-100 protein in histiocytic lesions of the skin. A comparative immunohistochemical study.
In this work the potential usefulness of antibodies to S-100 protein and the lectin Peanut Agglutinin (PNA) in the differential diagnosis of histiocytic lesions of the skin was assessed. Out of 54 deparaffinized specimens studied through an avidin-biotin-alkaline phosphatase technique, 35 proved to comprise S-100 (+) and 12 PNA (+) cells. The results show that antibodies to S-100 protein are useful in distinguishing the "X" (Langerhans' cell) from the "non-X"types of histiocytosis, and cast some shadow on the usefulness of the lectin PNA as a histiocytic marker. (Received May 5, 1987.)
D010367:Arachis; D001665:Binding Sites; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000473:pathology; D037102:Lectins; D037121:Plant Lectins; D009418:S100 Proteins; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
D037102:Lectins; D037121:Plant Lectins; D009418:S100 Proteins