title: Suppression of murine IgE responses with amino acid polymer/allergen conjugates. V. By intranasal administration.
abstract: Serum IgE antibody responses were generated in mice by intranasal exposure to grass pollen extract. Primary IgE responses were suppressed by the concomitant intranasal administration of a conjugate of polysarcosine and pollen extract which has been shown to be a potent tolerogen when given parenterally. Partial suppression of boosted IgE responses was observed when the conjugate was applied intranasally with a secondary challenge of unmodified extract. The data suggest that clinical schedules of intranasal application of tolerogenic conjugates can be devised to bring about specific IgE suppression.
mesh_terms: D000281:Administration, Intranasal; D000485:Allergens / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D007108:Immune Tolerance; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D010455:Peptides / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012521:Sarcosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000485:Allergens; D010455:Peptides; C015475:polysarcosine; D007073:Immunoglobulin E; D012521:Sarcosine