[Emetic and antiemetic properties of regulatory peptides].
Emetic and antiemetic properties of opioid peptides, substance "P", beta-lipotropin, and ACTH1-39 have been investigated in experiments on cats. It was shown that morphine, enkephalin, beta-endorphin and DADLE caused vomiting in animals, which was blocked by naloxone. Substance "P", gamma- and des-tyr-gamma-endorphin manifested antiemetic properties similar to those of naloxone. Selective antagonists of delta-opioid receptors ICI 154, 129 blocked emetic action of delta-agonist DADLE but did not prevent vomiting caused by mu-agonist morphine. It is suggested that the vomiting mechanisms of endogenous opioid peptides involve stimulation of mu- and delta-opioid receptors in the chemoreceptor trigger zone of the vomiting centre.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D000932:Antiemetics; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004639:Emetics; D004723:Endorphins / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology; D007276:Injections, Intraventricular; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D013997:Time Factors; D008083:beta-Lipotropin / Q000494:pharmacology
D000932:Antiemetics; D004639:Emetics; D004723:Endorphins; D004745:Enkephalins; D010455:Peptides; D013373:Substance P; D009270:Naloxone; D009020:Morphine; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin
Ob émeticheskikh i antiémeticheskikh svoĭstvakh nekotorykh reguliatornykh peptidov.