HLA-B39 and the axial type of psoriatic arthritis.
The frequency distribution of HLA-B38 and HLA-B39 was studied in a group of 50 unrelated psoriatic arthritis patients. A high increase of HLA-B39 was noted in the subgroup with axial arthropathy. All B39 positive patients presented with spondylitis and/or sacroiliitis. The hypothesis is formulated that HLA-B39 may discriminate a genetic subset of psoriatic arthritis characterized by a particular susceptibility to develop axial involvement.
D001168:Arthritis / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D059945:HLA-B38 Antigen; D059946:HLA-B39 Antigen; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000276:immunology*; D012446:Sacroiliac Joint; D013166:Spondylitis / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; D059945:HLA-B38 Antigen; D059946:HLA-B39 Antigen