The comparative pharmacokinetics of 3H-dihydrostreptomycin in solution and liposomal form in normal and Mycobacterium tuberculosis infected mice.
In intact and tuberculous mice a comparative pharmacokinetics of 3H-dihydrostreptomycin (DHS) encapsulated into the liposomes (LE) prepared from egg lecithin and soluble form of DHS (SOL) after their intravenous administration has been studied. The values of the total area under the serum concentration--time curve of DHS (AUC 0----infinity), administered in the LE form was 8.8 times higher in normal and 5.9 times higher in mice with advanced tuberculosis than in mice treated with soluble form of DHS (SOL). AUC 0----infinity values in spleen and liver were 2.2 and 4.5 times higher, respectively, in use of LE form, where as AUC 0----infinity values in lungs and kidneys were independent from the drug form of DHS in normal mice. DHS levels in lungs of tuberculous mice were 3 times higher 3 hours after administration of LE in comparison with those after SOL DHS. AUC 0----infinity values in spleen and liver of tuberculous mice were 9.2 and 7.3 times higher, respectively, in comparison with those after SOL DHS. AUC 0----infinity values in kidneys of tuberculous mice didn't differ significantly independently from the use of one or another form of the drug.
D000818:Animals; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008081:Liposomes; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000382:microbiology
D008081:Liposomes; D004096:Dihydrostreptomycin Sulfate