Excitatory action of BAYK8644 on hippocampal pyramidal neurones of the guinea pig in vitro.
BAYK8944, a calcium 'agonist' caused a slow depolarization of a proportion of CA1 hippocampal pyramidal cells and increased their input resistance. In voltage-clamped CA1 neurones BAYK8644 caused a decrease in depolarization-activated outward current. Reduction of depolarization-activated outward current was also produced by the Ca ionophore A23187. It is proposed that BAYK8644 and A23187 may cause suppression of outward current secondary to a prolonged increase in cytosolic Ca activity.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009553:Nimodipine / Q000494:pharmacology; D011188:Potassium / Q000502:physiology*
D007473:Ion Channels; D000001:Calcimycin; D009553:Nimodipine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D011188:Potassium; D002118:Calcium