The influence of human allergic encephalitogenic peptide on cell-mediated cytotoxicity reactions in patients with multiple sclerosis.
Multiple sclerosis patients and normal control persons were assayed for cell-mediated cytotoxicity against target cells coated with human allergic encephalitogenic peptide. Coating of different types of target cells resulted in increased cytotoxicity, most clearly seen against homologous lymphocytes and virus-infected fibroblasts. Both patients and controls showed reactivity against coated targets. A possible role for this type of reaction in the pathogenesis of multiple sclerosis is proposed.
D000328:Adult; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002645:Chickens; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology*
D004676:Myelin Basic Protein