title: Immunohistochemical demonstration of hyalinosis-associated 90 kD glycoprotein in amyloid deposits of lichen amyloidosus.
abstract: Immunohistochemical methods were used to study the nature of the amyloid deposits in lichen amyloidosus, in nodular amyloidosis, and in the cutaneous amyloid deposits found in Finnish-type systemic amyloidosis. In every case the anti-keratin serum stained the epidermis and sweat ducts but not the amyloid itself. None of the amyloids stained with anti-sera to prealbumin, to serum amyloid A protein, or to the free kappa or lambda light chains of immunoglobulins. In lichen amyloidosus but not in the other types of amyloidosis the amyloid substance stained intensely with the anti-serum to 90 kD glycoprotein. This glyco-protein, which is present in the basal cells of the hair follicles of normal skin, was first isolated from the extensive cutaneous deposits of a patient with a nonamyloid disease. The demonstration of this glycoprotein in lichen amyloidosus but not in nodular amyloidosis suggest a difference in pathogenesis between the two diseases. Tests for 90 kD glycoprotein may prove to be of value in the differential diagnosis of cutaneous amyloidosis.
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D013194:Staining and Labeling
chemical_list: D006023:Glycoproteins