Orthograde and retrograde axonal transport of dopamine-beta-hydroxylase in ileal mesenteric nerves of rats with chronic streptozotocin diabetes.
Rats with chronic streptozotocin-induced diabetes develop a neuropathy involving the ileal mesenteric nerves. Distal portions of these postganglionic sympathetic axons develop markedly dilated, dopamine-beta-hydroxylase (DBH)-containing dystrophic swellings. These findings led us to develop a quantitative method to examine orthograde and retrograde axonal transport of DBH in ileal mesenteric nerves. Surprisingly, no significant alteration in orthograde or retrograde axonal transport of DBH was identified.
D000818:Animals; D001370:Axonal Transport; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D007082:Ileum / Q000294:innervation; D008643:Mesentery / Q000294:innervation; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D013564:Sympathetic Nervous System / Q000473:pathology / Q000503:physiopathology*
D013311:Streptozocin; D004299:Dopamine beta-Hydroxylase