Thyroxine-induced changes of hepatic glucose-6-phosphatase activity and glycogen, protein, RNA and DNA contents in the rat.
Thyroxine (T4) in a dose of 0.1 microgram per g body weight caused in the rat a significant increase in hepatic glucose-6-phosphatase activity, while a reduction of this enzyme activity was observed after 1 microgram of T4 per g. The hepatic glycogen content was found to be depleted and a marked elevation in protein, RNA and DNA contents were observed after both doses of T4.
D000818:Animals; D001835:Body Weight; D004247:DNA / Q000032:analysis; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D008112:Liver Glycogen; D011506:Proteins; D012313:RNA; D004247:DNA; D005952:Glucose-6-Phosphatase; D013974:Thyroxine