Cytophotometry of granulocytes in chronic granulocytic leukaemia patients. Part II. Effects of chemotherapy on cell kinetics and cytochemical parameters of granulocytes.
A successful course of chemotherapy (myelosan or combined regimens) results in a two to eight fold decrease of the percentage of S + G2 cells in the bone marrow and peripheral blood and in the restoration of normal morphometric and cytochemical patterns of polymorphonuclear neutrophils in the chronic phase of CGL. In those patients of the chronic phase not responding to chemotherapy and in blast crisis the proportion of S + G2 cells did not change after a course of chemotherapy. Cytostatic drugs killed cells in all phases of the cell cycle. The initial response to chemotherapy was a slight increase of the proportion of S + G2 cells in peripheral blood, apparently as a result of the block in cell cycle transition which was followed by a rapid drop of S + G2 proportion. During chemotherapy such phenomena as an appearance of tetraploid mature neutrophils and of aneuploid clones were occasionally observed.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001752:Blast Crisis / Q000188:drug therapy / Q000473:pathology; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002066:Busulfan / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects*; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000378:metabolism; D006098:Granulocytes / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology
D004273:DNA, Neoplasm; D002066:Busulfan