[Repair of DNA damage induced by gamma radiation and UV and gamma mimetics in virus-infected human cells].
The method of chromatography of cell lysates on the columns with hydroxyapatite (HAP) and the method of ultracentrifugation of cell lysates in neutral sucrose gradient were used to study the mutagen-induced repair activity of human cells HEp-2 noninfected and chronically infected with measles and rubella viruses in order to determine the sedimentation properties of complexes containing DNA. Gamma-radiation, bleomycin, 4-nitroquinoline-1-oxide, and mitomycin C were used as DNA damaging agents. It was shown that the chronic infectious process inhibited repair of DNA damages induced by 4-nitroquinoline-1-oxide and mitomycin C and did not influence repair of DNA lesions caused by gamma-radiation and bleomycin.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D002460:Cell Line; D002472:Cell Transformation, Viral; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008459:Measles virus / Q000235:genetics; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009153:Mutagens; D012412:Rubella virus / Q000235:genetics; D014466:Ultraviolet Rays
D008937:Mitomycins; D009153:Mutagens; D001761:Bleomycin; D016685:Mitomycin; D015112:4-Nitroquinoline-1-oxide
Reparatsiia povrezhdeniĭ DNK, indutsirovannykh gamma-izlucheniem, UF- i gamma-mimetikami v infitsirovannykh virusami kletkakh cheloveka.