Chemical modifications of human and murine interferons.
Methods that modify the carbohydrate and peptide portions of human and murine interferons have been described. Such work has helped considerably in our understanding of these fascinating substances. The most powerful of the methods relies on gene manipulation: it has already led, and will lead in the future, to further species with altered biological activities. Some of them may prove clinically advantageous, but one will have to be aware of the fact that some of these "unnatural" interferons could lead to immunological complications.
D000818:Animals; D003545:Cysteine; D003553:Cystine; D004247:DNA / Q000378:metabolism; D006026:Glycoside Hydrolases; D006801:Humans; D007202:Indicators and Reagents; D007372:Interferons / Q000235:genetics / Q000378:metabolism; D051379:Mice; D010447:Peptide Hydrolases; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D003553:Cystine; D004247:DNA; D007372:Interferons; D006026:Glycoside Hydrolases; D010447:Peptide Hydrolases; D003545:Cysteine