Differences in open state of NBA-modified cardiac Na+ channels.
Patch clamp recordings from neonatal cardiac Na+ channels treated with N-bromoacetamide (NBA, 5-50 X 10- mol/l) showed modified Na+ channel activity. By chemical removal of inactivation, repetitive openings with an increased life time and burst-like activity occurred. NBA-modified Na+ channels differ in life time and may attain either a slightly (mean open time 3.1 +/- 0.2 ms) or a strongly (mean open time 15.2 +/- 1.4 ms) prolonged open state. This strongly suggests a heterogeneous population of NBA-modified Na+ channels in newborn rat cardiocytes.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D000081:Acetamides; D007473:Ion Channels; C016272:N-bromoacetamide