Impaired axonal transport of opiate and muscarinic receptors in streptozocin-diabetic rats.
Axonal transport of receptors was studied in streptozocin-diabetic rats using two different binding models. Streptozocin-induced hyperglycemia caused a reduced accumulation of muscarinic receptors above a ligature placed on rat sciatic nerves when the binding assay was performed in vitro with [3H]QNB. In the vagus nerve, the retrograde axonal transport of receptor-bound opiate was strongly decreased in the streptozocin-treated rats when [3H]lofentanil was used in vivo to label opiate receptors. Insulin partly reversed the changes observed in the streptozocin-treated rats. These findings suggest that impaired axonal transport of receptors may explain part of the neurological disturbance which is seen in diabetic patients.
D000818:Animals; D001370:Axonal Transport; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D005283:Fentanyl / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D010525:Peripheral Nerves / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism / Q000503:physiopathology; D013311:Streptozocin; D013997:Time Factors; D014630:Vagus Nerve / Q000378:metabolism / Q000503:physiopathology
D011976:Receptors, Muscarinic; D011957:Receptors, Opioid; D013311:Streptozocin; C034846:lofentanil; D005283:Fentanyl