Biochemical identification of the mucus of pseudomyxoma peritonei as the basis for mucolytic treatment.
Two cases of pseudomyxoma peritonei are presented. The gelatinous mucus was biochemically analyzed. The mucus contained approximately 98% protein and 2% to 5% carbohydrate per unit of dry weight. The predominant carbohydrate components were galactose and mannosamine. The mucus also had thromboplastic activity. Because of these findings, dextran sulfate, at concentrations between 2% and 10%, was instilled into the abdominal cavity and caused lysis of the mucus.
D000368:Aged; D016264:Dextran Sulfate; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009093:Mucus / Q000032:analysis*; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy* / Q000378:metabolism
D003911:Dextrans; D016264:Dextran Sulfate