Effects of pH on the Na-Ca exchange current in single ventricular cells of the guinea pig.
Using isolated guinea pig single ventricular cell, the sodium-calcium exchange current was recorded. Both internal and external acidification to pH 6 abolished most of the sodium-calcium exchange current and alkalinization to pH 8 decreased the exchange current. Thus, pH change modulates Na-Ca exchange current both from inside and outside of the cell.
D000818:Animals; D006168:Guinea Pigs; D006329:Heart Conduction System / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D016276:Ventricular Function
D007473:Ion Channels