title: Augmented antibody response to live attenuated measles vaccine in children with Plasmodium falciparum parasitaemia.
abstract: The impact of malarial infection on the humoral immunological response to measles virus antigen was studied in 184 children aged 8-19 months in Guinea-Bissau. Pre- and post-immunization measles serology was performed using dried blood on absorbent paper and the ELISA technique. Blood smears obtained at the time of vaccination and 2 and 4 weeks afterwards were examined for malaria parasites. Pre-vaccination antibodies to measles were found in 44 out of 184 children (24%). Plasmodium falciparum was identified in 62 of the 132 initially non-immune children who completed the study. The rate of seroconversion was 127 out of 132 (96%). Post-immunization measles antibody titres were significantly higher in the vaccinees with P. falciparum than in those without malaria parasites in the blood.
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006169:Guinea-Bissau; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000469:parasitology*; D008297:Male; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D010963:Plasmodium falciparum; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D014613:Vaccines, Attenuated