title: [Pion radiation therapy of non-resectable bone- and soft tissue sarcomas at the Swiss Institute for Nuclear Research].
abstract: A dynamic, tumor conforming treatment technique ("spot scan") for deep-seated tumors using pions (negative pi-mesons) has been in use at the Swiss Institute for Nuclear Research (SIN) since November 1981. This technique, with a favorable integral dose distribution, allows curative irradiation especially for large, unresectable tumors in the retroperitoneal and pelvic region. Between 1983 and 1986, 26 patients with sarcomas were treated: 18 had soft tissue sarcomas and 8 bone sarcomas. The tumor volumes ranged from 36 to 3400 cc. After previous therapy (23/26 patients) 14 out of 23 patients had progressive disease. In 20 fractions over 5 weeks a total dose of 30-36 Gy (90%-isodose) was administered. In a follow-up period of 9-50 months (median 14 months), the two year local control rate (Kaplan-Meier) for the soft tissue sarcomas was 93.3% and the two year survival rate 67.9%. Each of the 6 patients with bone sarcomas treated with curative intent showed clinically local tumor control. After a total dose of 30-36 Gy, no severe radiation induced morbidity was found.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy*; D004601:Elementary Particles; D005260:Female; D006801:Humans; D008297:Male; D008651:Mesons; D008875:Middle Aged; D010166:Palliative Care; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy*; D012509:Sarcoma / Q000532:radiotherapy*
vernacular_title: Pionen-Strahlentherapie nicht-resektabler Knochen- und Weichteilsarkome am Schweizerischen Institut für Nuklearforschung (SIN).