In vivo effects of corticosteroids on human allergic responses. I. Effects of systemic administrations of steroids.
In order to better understand the effects of corticosteroids in allergic disease, the relative degrees of allergen-induced cutaneous histamine release and granulocyte accumulation were evaluated in atopic volunteers following intravenous placebo or methylprednisolone administration. In nine subjects, a single intravenous dose of methylprednisolone (1 mg/kg) did not inhibit histamine release but did significantly reduce granulocyte accumulation at both allergen and buffer-challenged sites during five and one-half to six and one-half hours following steroid injection. These findings suggest that the corticosteroid-induced anti-inflammatory effects at allergic reaction sites do not include inhibition of local mediator release. Furthermore, the steroid-induced inhibition of inflammatory cell accumulation is not specific for the allergic reaction.
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001491:Basophils / Q000187:drug effects; D004334:Drug Administration Schedule; D004804:Eosinophils; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007958:Leukocyte Count; D008214:Lymphocytes; D008407:Mast Cells / Q000187:drug effects; D008775:Methylprednisolone / Q000008:administration & dosage; D009504:Neutrophils
D000305:Adrenal Cortex Hormones; D008775:Methylprednisolone