Collateral arterial tree and responses to serotonin.
Growing collateral arterial blood vessels are super-sensitive to serotonin. Advanced atherosclerosis causes platelet activation, and activated platelets release sufficient serotonin that collateral arterial spasm occurs as a response. The development of ketanserin, the 5-HT2-receptor blocker, has both identified the receptor responsible for the arterial spasm and provided new approaches to treatment.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000503:physiopathology; D001792:Blood Platelets / Q000502:physiology; D003097:Collateral Circulation / Q000187:drug effects*; D006801:Humans; D007650:Ketanserin / Q000627:therapeutic use; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology
D012701:Serotonin; D007650:Ketanserin