The sensitivity of domestic animal cell lines to eight recombinant human interferons.
The biological activities of eight recombinant human interferons (IFNs) were tested on permanent cell lines and low-passage embryonic cultures from domestic animal tissues. Each titer was compared to its titer on Madin-Darby bovine kidney (MDBK) cells. Although different cells within a species had different sensitivities to different IFNs, the order of sensitivity, in general, was ox, sheep, pig, cat, horse, and dog, the latter being quite insensitive to most IFNs.
D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D007372:Interferons / Q000494:pharmacology*; D011994:Recombinant Proteins; D013045:Species Specificity; D014762:Viral Interference / Q000187:drug effects
D011994:Recombinant Proteins; D007372:Interferons