title: The distribution and origin of calcitonin gene-related peptide-containing nerve fibres in feline dental pulp. Relationship with substance P-containing nerve fibres.
abstract: The origin and distribution of calcitonin gene-related peptide (CGRP)-like immunoreactivity in feline dental pulp were studied using indirect immunofluorescence. Nerve fibres with varicosities exhibiting CGRP-like immunoreactivity were observed to enter the pulp with blood vessels. Many CGRP-containing nerve fibres were found to extend along blood vessels in the central pulp, and some of these fibres exhibited a network arrangement in the walls of dental pulp blood vessels. However, some of fibres were apparently not associated with blood vessels. Some thin, CGRP-containing nerve fibres formed a part of the nerve plexus in the subodontoblastic area and penetrated into the odontoblastic layer. In animals that had undergone transection of the inferior alveolar nerve, no CGRP-containing nerve fibres were observed. Application of a double-immunofluorescence staining technique also revealed that the distribution of CGRP-containing nerve fibres is very similar to that of substance P-containing nerve fibres.
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002415:Cats; D003782:Dental Pulp / Q000294:innervation* / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism
chemical_list: D009479:Neuropeptides; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide