Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line.
Fibroblasts transformed by v-sis have elevated levels of c-fos relative to non-transformed controls. Transfection and integration of plasmids directing the synthesis of antisense RNA to the c-fos gene leads to restoration of density-dependent growth arrest in monolayer culture, but does not inhibit colony formation in soft agar.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology / Q000503:physiopathology*; D003260:Contact Inhibition; D005786:Gene Expression Regulation; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012313:RNA / Q000494:pharmacology*; D016372:RNA, Antisense; D014162:Transfection
D011518:Proto-Oncogene Proteins; D016372:RNA, Antisense; D012313:RNA