Human immunodeficiency virus replication in human brain cells. Brief report.
Human immunodeficiency virus (HIV), the etiologic agent of AIDS, was found to infect and replicate in human brain cells. The extent of HIV replication was minimal in human brain-derived cells in comparison to T4 lymphoid cells. These results suggest that direct infection of glial/neuronal cells by HIV may contribute to the CNS dysfunction frequently observed in HIV infected individuals.
D001921:Brain / Q000382:microbiology*; D002478:Cells, Cultured; D006678:HIV / Q000254:growth & development*; D006801:Humans; D066298:In Vitro Techniques; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013997:Time Factors; D014162:Transfection; D014779:Virus Replication
D012194:RNA-Directed DNA Polymerase