[Effect of amrinone and trapidil on adherence, migration and phagocytic behavior of neutrophilic granulocytes of the human].
Amrinone and trapidile belong to a group of positive inotropic and simultaneously vasodilating substances, whose effects are based on an inhibition of phosphodiesterase (PDE), thus enriching intracellular c-AMP. In neutrophilic granulocytes these PDE-antogonists will produce an inhibition of adherence and phagocytosis, whereas the migration was not affected. The lower leukocyte effective concentration of 10 mmol/l can be achieved by a therapeutical application, so that a slight inhibition of the leukocyte function has to be accounted for as a side effect.
D000676:Amrinone / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D014192:Trapidil / Q000494:pharmacology*
D011743:Pyrimidines; D000242:Cyclic AMP; D014192:Trapidil; D000676:Amrinone
Die Wirkung von Amrinon und Trapidil auf Adhärenz, Migration und Phagozytoseverhalten neutrophiler Granulozyten des Menschen.