title: Pituitary follicular cells produce basic fibroblast growth factor.
abstract: Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.
mesh_terms: D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D006224:Cricetinae; D005346:Fibroblast Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D009693:Nucleic Acid Hybridization; D010902:Pituitary Gland / Q000166:cytology* / Q000378:metabolism; D012313:RNA / Q000032:analysis
chemical_list: D005346:Fibroblast Growth Factors; D012313:RNA