Na-taurodeoxycholate acts as a specific intestinal stimulus of exocrine pancreatic secretion in man.
The effect of intraduodenally administered cattle bile, Na-taurodeoxycholate, and Na-taurocholate on secretin-stimulated exocrine pancreatic secretion was investigated on 40 fasting young healthy volunteers. Intraduodenal bile stimulated significantly and dose-dependently hydrokinetic and ecbolic pancreatic secretion. Only bile, but not secretin intravenously, both applied in a dosage equivalent with respect to their hydrokinetic action, caused a significant increase of enzyme output and enzyme concentration as well. Intraduodenal Na-taurodeoxycholate enhanced also dose-dependently secretin-stimulated volume, bicarbonate, and enzyme secretion. The effect was related to the load, not to the concentration of this bile salt. On the other side, Na-taurocholate had only a weak and not dose-dependent hydrokinetic and no ecbolic effect. It is concluded that not bile salts in general, but only certain of them--like Na-taurodeoxycholate--are the effective constituents of bile, acting as specific intraduodenal stimulants of hydrokinetic and ecbolic pancreatic secretion.
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000502:physiology*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004386:Duodenum; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology*; D013657:Taurodeoxycholic Acid / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D003840:Deoxycholic Acid; D012633:Secretin; D013657:Taurodeoxycholic Acid; D013656:Taurocholic Acid; D008049:Lipase; D000681:Amylases; D014357:Trypsin