The mode of action of some antibiotics on red blood cell membranes.
Data are presented on the interaction of gramicidin, primycin and valinomycin with red blood cell membranes and compared with those obtained for artificial lipid bilayer membranes. The channel forming antibiotics gramicidin and primycin show specific kinetic behaviour in living cell membranes. It could be shown that the penetration of these antibiotics into the red blood cell membrane is a cooperative process resulting in the occurrence of aggregates in the lipid lattice of the membrane.
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006096:Gramicidin / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D007700:Kinetics; D007783:Lactones / Q000378:metabolism / Q000494:pharmacology; D008051:Lipid Bilayers; D018942:Macrolides; D008954:Models, Biological; D014634:Valinomycin / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007473:Ion Channels; D007783:Lactones; D008051:Lipid Bilayers; D018942:Macrolides; D006096:Gramicidin; D014634:Valinomycin; C009041:primycin