Effect of starvation on susceptibility of rat liver nuclei to DNase I.
Starvation is characterized by rapid loss in liver weight, with marked decrease in total liver RNA and nuclear RNA. Decrease in in vivo nuclear RNA synthesis as measured by radioactive precursor incorporation is a significant contributing factor. Limited digestion of nuclei from starved animals with DNase I indicates no difference in comparison with control-fed rats, suggesting that the transcriptional units are retained in activable state.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003850:Deoxyribonuclease I / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D009711:Nucleotides / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D014158:Transcription, Genetic; D014529:Uridine / Q000378:metabolism
D009711:Nucleotides; D012313:RNA; D003850:Deoxyribonuclease I; D014529:Uridine