Comparative toxicity and biotransformation of lindane in C57BL/6 and DBA/2 mice.
DBA/2 mice, previously identified as "unresponsive" to aromatic hydrocarbons which induce microsomal enzymes in C57BL/6 mice, are more vulnerable to the convulsant effect of repeated doses of lindane than similarly treated C57BL/6 mice. Death in convulsions and higher blood and brain lindane concentrations indicate that less efficient disposition of lindane itself accounts for the greater vulnerability of the DBA/2 mice. The same two principal chlorophenolic metabolites of lindane were identified in the blood and tissues of both strains, but the time-courses of blood concentrations in response to repeated lindane dosing were different.
D000818:Animals; D001711:Biotransformation; D004351:Drug Resistance; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced*; D013045:Species Specificity
D001556:Hexachlorocyclohexane