Interaction of ranitidine and famotidine with guinea pig-isolated parietal cells.
The inhibitory effects of the histamine H2-receptor antagonists, ranitidine and famotidine on histamine-stimulated gastric acid secretion have been studied in guinea pig isolated, enriched parietal cells using the 14C-aminopyrine accumulation technique. The 14C-aminopyrine accumulation curves in response to histamine were shifted towards the right in a parallel fashion by ranitidine, and in a nonparallel fashion by famotidine. The inhibitory effect of ranitidine, but not that of famotidine, was readily reversed by washing the parietal cells. It is concluded that the histamine H2-receptors in guinea pig parietal cells are blocked competitively and reversibly by ranitidine, but noncompetitively and partially reversibly by famotidine.
D000818:Animals; D015738:Famotidine; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D010295:Parietal Cells, Gastric / Q000187:drug effects* / Q000378:metabolism; D011899:Ranitidine / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D006635:Histamine H2 Antagonists; D013844:Thiazoles; D015738:Famotidine; D006632:Histamine; D011899:Ranitidine