[Comparison of the distribution and toxicity of alpha-, beta-, and gamma-hexachlorocyclohexane (HCH) following 30 days of administration to rats].
Administration of 1000 ppm alpha-HCH, 600 ppm beta-HCH and greater than or equal to 125 ppm gamma-HCH to rats caused a growth retardation. alpha-HCH and beta-HCH led to livermass enlargement. beta-HCH caused a decrease of absolute brain-mass. In case of alpha-HCH and gamma-HCH fat tissue, kidneys and adrenals had a high burden in residues. Fat tissue and adrenals had high residues of beta-HCH. The level of HCH-residues during the test period was gamma much less than beta less than alpha. The results are discussed taking into account the contradictory knowledge from literature.
D000818:Animals; D001556:Hexachlorocyclohexane / Q000378:metabolism / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013997:Time Factors; D014018:Tissue Distribution
C040534:alpha-hexachlorocyclohexane; D001556:Hexachlorocyclohexane; C023888:beta-hexachlorocyclohexane
Vergleich der Verteilung und Toxizität von alpha-, beta- und gamma-Hexachlorcyclohexan (HCH) nach 30tägiger Verabreichung an Ratten.