Overlapping two genes in human DNA: a salivary amylase gene overlaps with a gamma-actin pseudogene that carries an integrated human endogenous retroviral DNA.
The human salivary amylase gene (amy1), consisting of eleven exons, is expressed in the salivary gland and in some amylase-producing tumors. Its uppermost exon and the following intron, along with the 5'-flanking region of this gene, are shown to be superimposed with a gamma-actin pseudogene sequence, a portion of which is transcribed into salivary amylase mRNA and another portion of which serves as a promoter for the amy1 gene. In the further upstream region, the gamma-actin pseudogene sequence is interrupted by a human endogenous retroviral nucleotide sequence.
D000199:Actins / Q000235:genetics*; D000681:Amylases / Q000235:genetics*; D001483:Base Sequence; D004274:DNA, Recombinant; D004279:DNA, Viral / Q000235:genetics*; D005796:Genes; D005807:Genes, Overlapping; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011544:Pseudogenes; D012190:Retroviridae / Q000235:genetics*; D012469:Salivary Glands / Q000201:enzymology
D000199:Actins; D004274:DNA, Recombinant; D004279:DNA, Viral; D000681:Amylases