Tolerance to fenfluramine anorexia: fact or fiction?
Recent findings in this laboratory with regard to tolerance to fenfluramine anorexia are reviewed with respect to generality of the behavioural phenomenon. A systematic relationship between initial body weight and fenfluramine-induced weight change in rats is described. The possible roles of peripheral factors in fenfluramine anorexia and tolerances, including gastric emptying and peripheral serotonin, are discussed. The role of central factors is also considered. It appears that fenfluramine, and possibly other anorectic agents have multiple sites of action and affect multiple behaviours. Some clinical implications are noted.
D000818:Animals; D001521:Behavior Therapy; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004361:Drug Tolerance; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology* / Q000627:therapeutic use; D005746:Gastric Emptying / Q000187:drug effects; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007422:Intestines / Q000187:drug effects; D008297:Male; D009642:Norfenfluramine / Q000494:pharmacology; D009765:Obesity / Q000628:therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects; D012701:Serotonin / Q000032:analysis; D013270:Stomach / Q000187:drug effects
D009642:Norfenfluramine; D005277:Fenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid