Furosemide-sensitive sodium and potassium fluxes in human neonatal erythrocytes.
During the course of incubation, in vitro, in a saline medium, we found an increase of cell volume and Na+ content in human neonatal erythrocytes (NNE), from the umbilical cord. The increased cell volume was dependent on the major anion in the medium in that replacement of Cl- by NO-3 abolished the cell volume increase. In erythrocytes from adults neither the cell volume nor the sodium content were altered under similar incubation conditions. Furosemide-sensitive Na+ and K+ fluxes were at variance from those reported from adult erythrocytes. The differences here presented between both cell types would be another instance of changes observed to occur in erythrocytes during the postnatal period.
D000367:Age Factors; D001692:Biological Transport / Q000187:drug effects; D002712:Chlorides / Q000097:blood; D004912:Erythrocytes / Q000502:physiology*; D005312:Fetal Blood / Q000502:physiology*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009566:Nitrates / Q000097:blood; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002712:Chlorides; D009566:Nitrates; D005665:Furosemide; D012964:Sodium; D011188:Potassium