Effect of gamma-hexachlorocyclohexane (lindane) on carp (Cyprinus carpio). II. Effects of chronic intoxication on blood, liver enzymes, and muscle plasmic membrane.
A 30-day ingestion of gamma-hexachlorocyclohexane (lindane) by carp (Cyprinus carpio) induced hypoglycemia without activation of two hepatic gluconeogenesis enzymes (fructose diphosphatase, EC 4.1.2.13, and glucose-6-phosphatase, EC 3.1.3.9) and hyponatremia and variations in muscle plasmic membrane-bound enzymes (especially cholinesterases, EC 3.1.1.7). After 109 days carps exhibited a decrease in natremia but no significant hypoglycemia. There was an activation of gluconeogenesis enzymes. Important changes were observed in the activities of muscle plasmic membrane enzymes (especially 5'-nucleotidase, EC 3.1.3.5, and ATPases, EC 3.6.1.3). Lindane, a lipophilic substance, especially disturbed the activity of membrane-bound enzymes enclosed in a phospholipid matrix.
D015720:5'-Nucleotidase; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002347:Carps / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects*; D003530:Cyprinidae / Q000378:metabolism*; D005943:Gluconeogenesis / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000097:blood / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009132:Muscles / Q000187:drug effects*; D009708:Nucleotidases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
D001786:Blood Glucose; D010743:Phospholipids; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D001556:Hexachlorocyclohexane; D012964:Sodium; D000110:Acetylcholinesterase; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000254:Sodium-Potassium-Exchanging ATPase