Specific reactions and cross reactions of anti-penicilloyl antibodies.
In human sera the specific reactions and cross reactions of antibodies directed against the penicilloyl groups were determined using different penicilloyl derivatives as antigen. The penicilloyl group providing the highest titre in one Ig class was said to define the specific reaction for this Ig class. This criterium was justified by the fact that antibodies evoked by long-term treatment with benzylpenicillin showed specific reaction to the benzylpenicilloyl group. Moreover, specific reactions of antibodies of different Ig classes in one serum were the same. Both the side chain and the thiazolidine ring of the penicilloyl group can serve as antigenic determinants.
D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D010406:Penicillins / Q000276:immunology*; D013329:Structure-Activity Relationship
D000906:Antibodies; D000939:Epitopes; D007074:Immunoglobulin G; D010406:Penicillins