title: [Normalization of the functional regulation of the thyroid as a criterion of the remission of diffuse toxic goiter following antithyroid treatment].
abstract: Triiodothyronine test was applied to 72 patients with toxic goiter treated with antithyroid drugs to reveal whether the regulation of thyroid function was normal. During a one-year observation period the patients underwent check-ups every third month, then during three years the examination was performed every half a year. A final examination was 10 years after the treatment. In the process of treatment the regulation of thyroid function recovered in 44 (68.7%) out of 64 patients, but further the relapse of goiter was recorded in 10 of them. Among 20 patients whose regulation of thyroid function failed to be normalized after a 18-months treatment the relapse was noted in 17 patients (85%). 27 patients (42.2%) had a relapse ten years after the exposure. The lack of normal regulation of thyroid function revealed with T3 test permits the relapse of toxic goiter to be predicted.
mesh_terms: D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000188:drug therapy / Q000503:physiopathology; D006111:Graves Disease / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D014284:Triiodothyronine
vernacular_title: Normalizatsiia reguliatsii funktsii shchitovidnoĭ zhelezy kak kriteriĭ remissii diffuznogo toksicheskogo zoba posle lecheniia antitireoidnymi preparatami.