title: A malaria protein exported into a new compartment within the host erythrocyte.
abstract: A Plasmodium falciparum protein which is exported into a new compartment in the host erythrocyte has been located. This protein, exp-1, has a variable region recognized by a monoclonal antibody. Naturally occurring mutants of this region have been characterized. All mutants studied so far have the same A----G transition abolishing the target for the antibody. The exp-1 gene has a complex structure containing two introns. It is highly conserved in five independent, genetically defined parasite lines, suggesting that exp-1 has an important function. We discuss the possible role of exp-1 in P. falciparum infections.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D000939:Epitopes / Q000032:analysis; D004926:Escherichia coli / Q000235:genetics; D005796:Genes; D008288:Malaria / Q000097:blood*; D010963:Plasmodium falciparum / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis
chemical_list: D000953:Antigens, Protozoan; D002352:Carrier Proteins; D000939:Epitopes