The effects of prostaglandins of the E and I type on histamine release from human adenoidal mast cells.
(PgE1 (10(-8)-10(-6) M) inhibited dose dependently the Con A-induced histamine release from human adenoidal mast cells. Out of two stable PgI analogues tested, EL 784 had a slight inhibitory effect at 10(-10) M, and SE 63 at 10(-4) M. PgI2 itself was ineffective.
D000234:Adenoids / Q000166:cytology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D011464:Epoprostenol