title: [Significance of cytogenetic studies in the preleukemias].
abstract: In cytogenetic examinations made on 60 patients in preleukemic states an instable karyotype could be identified in 28% of all cases and anomalous clones in 12.3%. The dynamics of transition to acute leukemia was pursued in seven cases. The instability of the karyotype is conceived of as a sign of increased risk to developing leukemia and the presence of anomalous clones as an evidence of a leukemic process.
mesh_terms: D000208:Acute Disease; D000741:Anemia, Aplastic / Q000235:genetics; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D005199:Fanconi Anemia / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics; D011003:Ploidies; D011289:Preleukemia / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm
vernacular_title: Die Bedeutung zytogenetischer Untersuchungen bei Präleukämien.