[Ploidy level and alpha-fetoprotein production in spontaneous murine hematomas in relation to the degree of histological differentiation].
Comparative morphological, cytospectrophotometric and immunochemical studies were carried out on 26 hepatocarcinomas of various malignancy excised from 21 F1 (CBA X C57B16) mice. It has been shown that in morphologically similar hepatomas the ploidy level and alpha-fetoprotein production intensity may vary markedly. Highly differentiated carcinomas usually of smaller sizes and homogeneous morphology have the modal class nuclei with tetraploid (6 cases) or octaploid (3 cases) DNA content. In moderately- and low-differentiated carcinomas the diploid class of nuclei significantly increased (in 4 out of 6 tumours). Large tumours morphologically heterogeneous according to the differentiation level had polymodal DNA distributions with predominating tetraploid nuclei (II cases).
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000032:analysis* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D006651:Histocytochemistry; D008114:Liver Neoplasms, Experimental / Q000032:analysis / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011003:Ploidies; D000509:alpha-Fetoproteins / Q000032:analysis*
D004273:DNA, Neoplasm; D000509:alpha-Fetoproteins
Uroven' ploidnosti i produktsiia al'fa-fetoproteina v spontannykh gepatomakh mysheĭ v zavisimosti ot stepeni gistologicheskoĭ differentsirovki.