Comparison of substance K-like and substance P-like fibers and cells in the rat hippocampus.
Substance P (SP) and substance K (SK) are structurally related peptides which are both encoded in the preprotachykinin A gene. The distribution of SP- and SK-like fibers and cell bodies in the rat hippocampus were studied by immunohistochemistry. The distribution of SK-like fibers was similar to that of SP-like fibers but there were few SK-like fibers. Fibers for both peptides were prominent in the dorsal and ventral subiculum and at the junction of CA2 and CA3. SP- and SK-like cell bodies were noted in the subiculum and in the stratum oriens of CA1 and CA2. SP- and SK-like cells were also noted in the ventral dentate gyrus but only SP-like cells were found in the dorsal dentate gyrus.
D000818:Animals; D006624:Hippocampus / Q000033:anatomy & histology* / Q000166:cytology; D007150:Immunohistochemistry; D008297:Male; D015288:Neurokinin A; D009479:Neuropeptides / Q000032:analysis* / Q000276:immunology; D011712:Pyramidal Tracts / Q000033:anatomy & histology / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis* / Q000276:immunology
D009479:Neuropeptides; D013373:Substance P; D015288:Neurokinin A