A polypeptide toxin from the coral Goniopora. Purification and action on Ca2+ channels.
A polypeptide toxin has been isolated from Goniopora coral with an Mr of 19 000. Goniopora toxin has the following properties: it induces contraction of guinea pig ileum and this contraction is prevented by Ca2+-channel blockers; it stimulates 45Ca2+ influx in cardiac cells in culture and this stimulation is abolished by Ca2+-channel blockers; it prevents binding of (+)-[3H]PN 200-110 to the Ca2+-channel protein of skeletal muscle T-tubule membranes. All these results taken together suggest that Goniopora toxin is a Ca2+-channel activator.
D000818:Animals; D001681:Biological Assay; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D002642:Chick Embryo; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D036341:Intercellular Signaling Peptides and Proteins; D007473:Ion Channels / Q000187:drug effects*; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D009568:Nitrendipine; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D036341:Intercellular Signaling Peptides and Proteins; D007473:Ion Channels; D010455:Peptides; D013779:Tetrodotoxin; C020348:goniopora toxin; D009568:Nitrendipine; D009543:Nifedipine; D002118:Calcium