The M gamma chain of human fetal hemoglobin.
A new gamma chain of human fetal hemoglobin, the M gamma chain, has been detected by high performance liquid chromatography (HPLC). It is characterized by a Leu----Met replacement at position gamma 141; no other structural variations have been found. The M gamma chain has been observed in red cell lysates of subjects with a heterozygosity for one of many types of hereditary persistence of fetal hemoglobin (HPFH), in sickle cell anemia, and in a few cord blood samples. At present, the genetic cause of this newly discovered heterogeneity is not known; an infidelity in translation or the existence of an unrecognized gamma globin gene should be considered.
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D005319:Fetal Hemoglobin / Q000235:genetics* / Q000302:isolation & purification; D006453:Hemoglobinopathies / Q000097:blood / Q000235:genetics; D006801:Humans; D007930:Leucine; D046911:Macromolecular Substances; D008715:Methionine; D008969:Molecular Sequence Data
D046911:Macromolecular Substances; D005319:Fetal Hemoglobin; D008715:Methionine; D007930:Leucine