Dose-response effects of Desmodium adscendens aqueous extract on histamine response, content and anaphylactic reactions in the guinea pig.
Different concentrations of a hot water extract of Desmodium adscendens, a plant used in Ghana to control asthmatic attacks, were used in drinking water to evaluate the plant's anti-anaphylactic properties in guinea pigs. The results show that the extract's inhibition of histamine-induced ileal contraction is largely competitive and that its effect of reducing lung histamine content is dose-dependent. The results also show that the extract causes a dose-dependent reduction in the amount of spasmogens released anaphylactically and in anaphylactic-induced contraction of ileal muscle.
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005869:Ghana; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*
D010936:Plant Extracts; D006632:Histamine