Effects of a high-voltage electrical impulse and an anticancer drug on in vivo growing tumors.
Application of a high-voltage electrical impulse (5 kV/cm, 2 msec) after bleomycin administration resulted in a significant size decrease of subcutaneously inoculated AH-109A hepatocellular carcinoma in Donryu rats. The tumor size decreased to an average of 17% of the initial mass 4 days after the treatment. Neither the high-voltage electrical impulse nor bleomycin administration alone showed an inhibitory effect on the tumor growth. It was concluded that the concomitant use of a high-voltage electrical impulse and an anticancer drug has the potential to be applicable for cancer treatment.
D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001761:Bleomycin