Sensitizing capacity of 4,4(1)-dihydroxy-(hydroxymethyl)-diphenyl methanes in the guinea pig.
The sensitizing capacity of 4,4(1)-dihydroxy-3-(hydroxymethyl)-diphenyl methane (4,4(1)-H-3-HPM), 4,4(1)-dihydroxy-3,3(1)-di-(hydroxymethyl)-diphenyl methane 4,4(1)-H-3,3(1)--HPM) and 4,4(1)-dihydroxy-3,5-di-(hydroxymethyl)-diphenyl methane (4,4(1)-H-3,5-HPM) was investigated using the guinea pig maximization text. These compounds are known contact sensitizers in phenol-formaldehyde resins (P-F-R). The study was performed in order to assess and compare the degrees of the sensitizing capacities of these chemically related substances. The animals were also rechallenged with the sensitizer and 5 related compounds, all known to be present in P-F-R, in order to study the cross-reaction patterns. 4,4(1)-H-3,3(1)-HPM was demonstrated to be a strong sensitizer and 4,4(1)-H-3-HPM and 4,4(1)-H-3,5-HPM to be moderate sensitizers. With 4,4(1)-H-3,3(1)-HPM as the sensitizer, 4,4(1)-H-3-HPM and 4,4(1)-H-3,5-HPM were cross-reacting substances and simple methylol phenols were possible cross-reacting compounds. Possible cross-reactivity were indicated between the three 4,4(1)-H-HPM when 4,4(1)-H-3-HPM and 4,4(1)-H-3,5-HPM respectively were the sensitizers. The chemical investigation by high pressure liquid chromatography indicated that the compounds tested were pure and separable.
D000818:Animals; D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D005557:Formaldehyde; D006168:Guinea Pigs; D010636:Phenols; D011108:Polymers
D001559:Benzhydryl Compounds; D010636:Phenols; D011108:Polymers; D005557:Formaldehyde; C049217:4,4'-dihydroxy-3,3'-di-(hydroxymethyl)diphenylmethane; C011529:phenol-formaldehyde resin; C049218:4,4'-dihydroxy-3,5-di-(hydroxymethyl)diphenylmethane