title: Immunologic histamine release from isolated human basophils during specific immunotherapy.
abstract: Anti-IgE- and antigen-induced histamine release from basophils isolated from 20 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with Pollinex. It was shown, that after hyposensitization a significant decrease on anti-IgE and specific antigen-induced histamine release from basophils occurs.
mesh_terms: D000485:Allergens / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000627:therapeutic use; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000378:metabolism; D004338:Drug Combinations / Q000276:immunology; D005976:Glutaral / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007167:Immunotherapy; D066298:In Vitro Techniques; D010936:Plant Extracts; D011058:Pollen / Q000276:immunology; D014443:Tyrosine / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D004338:Drug Combinations; D010936:Plant Extracts; D007073:Immunoglobulin E; D014443:Tyrosine; C014155:Parietaria judaica pollen; D005976:Glutaral