In vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle.
A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro. It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).
D000818:Animals; D000831:Animals, Newborn; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts; D006020:Glycopeptides / Q000494:pharmacology*; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D006020:Glycopeptides; D000511:alpha-Macroglobulins