title: Phenocopies induced with antisense RNA identify the wingless gene.
abstract: Earlier work suggested that the wingless gene of Drosophila is required for cooperation within discrete groups of cells during development. We show that antisense RNA made from a 3 kb transcript produces wingless mutant phenocopies when injected into wild-type eggs, proving that this transcript executes the wingless function. In the accompanying paper, Rijsewijk et al. report cloning of a Drosophila homolog (Dint-1) of the mouse int-1 gene and show that this gene is identical to wingless+. The partial sequence of the wingless cDNA that we have isolated is identical to part of the complete Dint-1 sequence described by Rijsewijk et al.
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D005796:Genes; D007301:Insect Hormones / Q000235:genetics*; D007814:Larva / Q000648:ultrastructure; D051379:Mice / Q000235:genetics; D009024:Morphogenesis; D010641:Phenotype; D012313:RNA / Q000235:genetics*; D016372:RNA, Antisense; D012689:Sequence Homology, Nucleic Acid
chemical_list: D007301:Insect Hormones; D016372:RNA, Antisense; D012313:RNA; D004247:DNA