[Comparative evaluation of the effect of kontrikal, 5-fluorouracil and the new Soviet peptide preparation dalargin on the course of experimental pancreonecrosis].
The experiments on 24 dogs with experimental hemorrhagic pancreonecrosis showed that contrykal and 5-fluorouracil insignificantly decrease the area of the damaged parenchyma, fail to cease progression of the pancreas destruction. The peptide drug dalargin in these conditions increased the antitryptic activity and normalized BAEE esterase activity. Dalargin abolished erythrostasis and microthromboses in the vessels of the microcirculation, restored the blood supply throughout the area of the exocrine parenchyma, limited necrotic foci and suspended the development of pancreonecrosis.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005472:Fluorouracil / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy / Q000503:physiopathology; D009336:Necrosis; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy* / Q000503:physiopathology
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D007611:Aprotinin; D005472:Fluorouracil; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Sravnitel'naia otsenka vliianiia kontrikala, 5-ftoruratsila i novogo otechestvennogo peptidnogo preparata dalargina na techenie éksperimental'nogo pankreonekroza.