An immunohistochemical study of intracranial germ cell tumours.
Histologically verified intracranial tumours, mainly germ cell tumours of the pineal and suprasellar regions, were studied immunohistochemically using anti-serum of alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA), human placental lactogen (HPL), pregnancy specific beta-1 glycoprotein (SP-1), glial fibrillary acidic protein (GFAP), S-100 and neuron specific enolase (NSE). In germinomas, HCG positive cells were occasionally demonstrated in cells presenting as syncytiotrophoblastic giant cells (STGC), and GFAP and S-100 positive cells were found in the surrounding gliotic lesions. Teratomas were positive for CEA in their epithelial components. Endodermal sinus tumours were positive for AFP, choriocarcinomas for HCG and SP-1, and embryonal carcinomas for AFP, HCG and SP-1. HCG and SP-1 positive cells were demonstrated in STGC. As for the relationship between serum AFP level and tissue localization, many cases presenting a serum AFP level exceeding 220 ng/ml were positive for AFP in tumour tissue.
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000032:analysis* / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002822:Choriocarcinoma / Q000032:analysis / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis; D004407:Dysgerminoma / Q000032:analysis / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008649:Mesonephroma / Q000032:analysis; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000032:analysis* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010871:Pinealoma / Q000032:analysis / Q000473:pathology; D010928:Placental Lactogen / Q000032:analysis; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013724:Teratoma / Q000032:analysis / Q000473:pathology; D000509:alpha-Fetoproteins / Q000032:analysis
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D005904:Glial Fibrillary Acidic Protein; D011268:Pregnancy-Specific beta 1-Glycoproteins; D009418:S100 Proteins; D000509:alpha-Fetoproteins; D010928:Placental Lactogen; D010751:Phosphopyruvate Hydratase