Alterations in protein, sialic acid and some enzymes in cervical mucus of female rats during NET-EN treatment.
The effect of norethisterone enanthate (NET-EN) on cervical mucus protein, sialic acid and some enzymes (e.g. peroxidase, alkaline phosphatase and alpha-amylase) were studied in adult female rats. One mg NET-EN every 12 days was found to be an effective contraceptive dose of this drug in this species, acting primarily through the cervical mucus. NET-EN produced a highly significant increase in protein content and peroxidase and alkaline phosphatase activities. However, sialic acid content and amylase activity did not exhibit any definite pattern after NET-EN therapy. The increased protein content together with persistent elevated levels of peroxidase and alkaline phosphatase corroborates the hypothesis that NET-EN creates a progestogenic phase which prevents sperm penetration and thus conception.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002582:Cervix Mucus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D004971:Estrus; D005260:Female; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000378:metabolism*; D013997:Time Factors
D003280:Contraceptives, Oral, Synthetic; D011506:Proteins; D012794:Sialic Acids; D000469:Alkaline Phosphatase; D000681:Amylases; C024319:norethindrone enanthate; D009640:Norethindrone