[Effect of the lipoxygenase blockader BW755C on calcium currents in the nerve cell membrane of the snail and on the contractile responses of the ureteral smooth-muscle fibers in the guinea pig].
Lipoxygenase blocker BW755C has been studied for its effect on calcium inward current in intracellularly perfused voltage clamped and contraction of guinea-pig ureter smooth muscle. BW755C increased the Ca inward current in somatic membrane and inhibited contraction of the smooth muscle evoked by high-potassium solution. It is suggested that the effects observed are related to the changes in the level of cyclic nucleotides in cytoplasm due to the action of the final products of lypoxygenase breakdown of fatty acids from the cell membrane.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006372:Helix, Snails / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects*; D016859:Lipoxygenase Inhibitors; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology*; D014513:Ureter / Q000187:drug effects
D007473:Ion Channels; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D002118:Calcium
Vliianie blokatora lipooksigenazy BW755C na kal'tsievye toki v membrane nervnoĭ kletki ulitki i sokratitel'nye otvety gladkomyshechnykh volokon mochetochnika morskoĭ svinki.