Peptide specificities of myelin basic protein-reactive human T-cell clones.
Forty myelin basic protein (BP)-reactive T-cell clones were isolated from a patient with multiple sclerosis and used to identify human T-cell recognition sites on the BP molecule. At least three sites have been identified: one in the N-terminal half of the molecule (residues 1-97), one in the C-terminal (residues 98-170), and one which spans residues 97-98. The clones exhibited a marked preference for the C-terminal half of the molecule. No cross-reactivity with measles virus was detected. These clones will be useful for both the further delineation of the human T-cell recognition sites on BP and the generation of anticlonotypic monoclonal antibodies.
D002455:Cell Division; D002999:Clone Cells; D000939:Epitopes; D006801:Humans; D008459:Measles virus / Q000276:immunology; D009103:Multiple Sclerosis / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000939:Epitopes; D004676:Myelin Basic Protein; D010446:Peptide Fragments