title: [Potential antiangiogenic substances from alpha,alpha'-bis(amidinobenzyl)cycloalkanone derivatives and alpha-(arylsulfonylamino)-omega-phenylcarboxylic acid-4-amidinoanilide].
abstract: Assuming that the immigration of endothelial cells from existing blood vessels into tissues to be vascularized is the first step of neoangiogenesis, we examined the potential antiangiogenic activity of some synthetic inhibitors of serine proteinases on the migratory rate of isolated endothelial cell using Boyden technique. The 4-amidinoanilide of 2-tosylamino-4-phenylbutyric acid was shown to be the most effective inhibitor. Its effect is probably caused by inhibition of the plasminogen activators of tissue type produced by the cells.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000578:Amidines / Q000138:chemical synthesis*; D000818:Animals; D001550:Benzamidines / Q000138:chemical synthesis* / Q000494:pharmacology; D001808:Blood Vessels / Q000187:drug effects / Q000254:growth & development*; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology; D009389:Neovascularization, Pathologic; D014105:Tosyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D062366:para-Aminobenzoates
chemical_list: D000578:Amidines; D001550:Benzamidines; D014105:Tosyl Compounds; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; C052876:2-tosylamino-4-phenylbutyryl-4-amidinoanilide; D010129:4-Aminobenzoic Acid
vernacular_title: Potentiell antiangiogene Substanzen aus der Gruppe der alpha,alpha'-Bis(amidinobenzyl)cycloalkanon-Derivate und alpha-(Arylsulfonylamino)-omega-phenylcarbonsäure-4-amidinoanilide.