[Animal experiment studies of hemostasis using the fibrinogen adhesive system on the liver and spleen in coagulation disorders].
Fresh resection areas after partial resection of liver and lien in rabbits were repaired and sealed by a fibrin film on conditions of hemorrhagic tendency and increased fibrinolysis. A strong damage in the wound area in the same way as in organic injury originates from these pathologic conditions. A premature demarcation of the external wound strata especially in raised fibrinolysis takes place by reason of the parenchymal necrosis though the fibrinogen is cross-linked to an intact film independent of the common circulation and clotting relations. An abundant wound revision is recommended before using the fibrin adhesive to prevent an after-bleeding.
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D006474:Hemorrhagic Disorders / Q000473:pathology*; D006487:Hemostasis / Q000187:drug effects*; D006498:Hepatectomy; D008099:Liver / Q000473:pathology; D011817:Rabbits; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013529:Surgical Wound Dehiscence / Q000473:pathology; D013917:Thrombin / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin
Tierexperimentelle Untersuchungen zur Blutstillung mittels des Fibrinogenklebesystems an Leber und Milz bei Gerinnungsstörungen.