[Immunohistochemical study of oncogene-related products in human gastrointestinal malignancies--expression of ras p 21, fes p 85 and EGF receptor].
An immunohistochemical examination by the avidin-biotin-peroxidase complex method was carried out to assess the expression of oncogene-related products, i.e., ras p 21 protein, fes p 85 protein and epidermal-growth-factor (EGF) receptors, in human gastrointestinal malignancies. The presence of ras p 21, fes p 85 and EGF receptors was detected in 48%, 62%, and 62% of 29 colorectal carcinomas and in 65%, 65% and 40% of 20 gastric cancers, respectively. More than one oncogene protein was demonstrated in 18 of 29 colorectal carcinomas and in 10 of 20 gastric cancers. These results suggest that multiple oncogenes are important in the occurrence and progress of gastrointestinal malignancies.
D003110:Colonic Neoplasms / Q000032:analysis* / Q000235:genetics; D066246:ErbB Receptors / Q000032:analysis*; D015683:Gene Products, gag; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D009856:Oncogene Proteins, Viral / Q000032:analysis*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D012004:Rectal Neoplasms / Q000032:analysis* / Q000235:genetics; D012191:Retroviridae Proteins / Q000032:analysis*; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000032:analysis* / Q000235:genetics
D015683:Gene Products, gag; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D012191:Retroviridae Proteins; D066246:ErbB Receptors; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)