The association of acute phase protein genes with the nuclear matrix of rat liver during experimental inflammation.
The association of acute phase protein genes with the nuclear matrix in livers from healthy rats and rats suffering from inflammation was studied. alpha 1-Acid glycoprotein and transthyretin are synthesized at low levels in normal liver and no matrix association of their genes was observed. Albumin, transferrin and the beta-chain of fibrinogen are synthesized at much higher levels in normal liver and their genes were found to be associated with the nuclear matrix. An inflammation induced increase in synthesis of alpha 1-acid glycoprotein and the beta-chain of fibrinogen resulted in stronger matrix association of their genes. However, inflammation induced decrease in the synthesis of albumin did not influence matrix association of its gene.
D000209:Acute-Phase Proteins; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism*; D005340:Fibrinogen / Q000235:genetics; D005786:Gene Expression Regulation; D007249:Inflammation / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000235:genetics; D011228:Prealbumin / Q000235:genetics; D051381:Rats; D011915:Rats, Inbred BUF; D012709:Serum Albumin / Q000235:genetics; D014158:Transcription, Genetic; D014168:Transferrin / Q000235:genetics
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D009961:Orosomucoid; D011228:Prealbumin; D012709:Serum Albumin; D014168:Transferrin; D005340:Fibrinogen