Intraventricular interferon in a case of subacute sclerosing panencephalitis.
A patient with subacute sclerosing panencephalitis (SSPE) was treated by direct administration of Interferon B into the cerebral ventricles. Immediately after the first dose intrathecal synthesis of IgG and the CNS antimeasles antibody titer fell significantly, only to rise again to the pretreatment levels 2 months after discontinuation of treatment. There was no improvement in the patient's clinical status.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D001769:Blood / Q000276:immunology; D001812:Blood-Brain Barrier; D002555:Cerebrospinal Fluid / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007276:Injections, Intraventricular; D007372:Interferons / Q000008:administration & dosage* / Q000627:therapeutic use; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007372:Interferons