Irreversible changes in rat erythrocyte Na+ transport systems with progesterone and estradiol administration.
In order to test whether alterations in Na+ transport systems occurring in women when the hormonal status is disturbed such as in pregnancy, under contraceptive or estradiol therapy are a direct result of hormonal action on these transport systems, Na+,K+-pump Na+,K+ outward cotransport and passive Na+ permeability were measured in erythrocytes of ovariectomized rats receiving estradiol or progesterone. No significant changes in Na+,K+-pump were observed in either conditions. Conversely, progesterone was found to decrease Na+, K+-cotransport and estradiol to increase this system, whereas both steroids increased passive Na+ permeability.
D000818:Animals; D001692:Biological Transport; D002034:Bumetanide / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters
D002352:Carrier Proteins; D007473:Ion Channels; D028021:Sodium-Potassium-Chloride Symporters; D002034:Bumetanide; D011374:Progesterone; D004958:Estradiol; D010042:Ouabain; D012964:Sodium; D011188:Potassium