[Morphofunctional changes in the chief cells of the intrinsic glands of the stomach in the presence of an excess of glucocorticoid and sex hormones in the body].
In 260 male white rats electron microscopically, cytochemically with biochemical estimation of proteolitic activity of gastric juice, it has been demonstrated that principle cells of the gastric glands, after injection of small doses of hydrocorticone, respond with a complex of adequate ultrastructural, cytochemical and functional changes directed to realization of the drugs stimulating effect. With increasing time of the experiment, or the doses, progressively developing distrophic processes, involving predominantly the protein-synthesizing apparatus and, to a less degree, the mitochondrial mechanism, are observed in the principle cells. This results in inhibition of the pepsinogene synthesis phase and in decreasing proteolytic activity of gastric juice. Reaction of the principle cells is independent on testosterone doses; the protein-synthesizing and mitochondrial (to a less degree) apparatuses develop; the pepsinogene extrusion phase is suppressed; it results in its deposition in cytoplasm and in decreasing proteolytic activity of gastric juice. When testosterone and hydrocortisone are injected simultaneously in small doses, the stimulating effect of hydrocortisone to the principle cells is abolished and at large doses it is sharply manifested and is not accompanied with destructive changes in the principle cells.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D012313:RNA; D010088:Oxidoreductases; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D006854:Hydrocortisone
Morfofunktsional'nye izmeneniia glavnykh kletok sobstvennykh zhelez zheludka pri izbytke v organizme gliukokortikoidnykh i polovykh gormonov.