[Effect of insulin on the calcium current of the frog myocardium].
The experiments on frog atra tuberculae revealed that insulin could induce biphasic changes of calcium currents of different directions. The current is inhibited with hormone due to a decrease both in the conductivity of channel system and reversal potential. In some cases prior to inhibition of calcium current, a short rise of this current occurred (3-6 min) induced by increased reversal potential. Possible mechanisms of insulin electrophysiological effects are discussed.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006325:Heart Atria; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011895:Rana ridibunda; D011972:Receptor, Insulin / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D007328:Insulin; D007473:Ion Channels; D000242:Cyclic AMP; D011972:Receptor, Insulin; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium
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