Sensory neuropeptides contribute to oedema formation in experimental burns.
The role of primary sensory neuropeptides in experimental burns was investigated. It was shown that after scalding, substance P-like immunoreactivity is released into the lymphatic fluid of dogs. Substance P, injected intravenously, was shown to cause dose-dependent oedema formation in rat skin, as measured with the Evans blue-technique. Furthermore, capsaicin pretreatment, which depletes the neuropeptide content of primary sensory neurons, was shown to inhibit late oedema formation in rats.
D000818:Animals; D002056:Burns / Q000150:complications*; D004285:Dogs; D004487:Edema / Q000209:etiology*; D051381:Rats; D013373:Substance P / Q000502:physiology*
D013373:Substance P