title: Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells.
abstract: Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.
mesh_terms: D000818:Animals; D001048:Aplysia / Q000502:physiology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism* / Q000494:pharmacology; D004594:Electrophysiology; D019835:FMRFamide; D006880:Hydroxy Acids / Q000378:metabolism; D006893:Hydroxyeicosatetraenoic Acids / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D015289:Leukotrienes; D008084:Lipoxygenase / Q000378:metabolism*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology; D010740:Phospholipases / Q000037:antagonists & inhibitors; D013569:Synapses / Q000502:physiology*
chemical_list: D001095:Arachidonic Acids; D006880:Hydroxy Acids; D006893:Hydroxyeicosatetraenoic Acids; D007473:Ion Channels; D015289:Leukotrienes; D009479:Neuropeptides; D016718:Arachidonic Acid; D019835:FMRFamide; C021201:12-HPETE; D008084:Lipoxygenase; D010740:Phospholipases