Acute toxicity of gliotoxin in hamsters.
Acute toxicity studies of gliotoxin were done in hamsters given oral doses of 15, 25 and 35 mg/kg of gliotoxin. Surviving hamsters were killed at 72 h post-treatment. Most hamsters in the middle and high dose groups were dead or moribund within 24 h. Hamsters in these dose groups that survived for greater than 12 h had hepatic alterations of necrotizing and proliferative cholangitis with marked lymphoplasmacytic pericholangitis.
D000818:Animals; D006224:Cricetinae; D005912:Gliotoxin / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009183:Mycotoxins / Q000633:toxicity*
D009183:Mycotoxins; D005912:Gliotoxin