Meningiomas. An immunohistochemical study of 50 cases.
Fifty formalin-fixed, paraffin-embedded meningiomas were studied with a panel of ten antibodies directed against epithelial antigens, intermediate filaments, and neuroectodermal antigens. Twenty-five (50%) of these were stained with monoclonal antibodies (MoAb) to epithelial membrane antigen (EMA), 12 (24%) with keratin antibodies, 9 (18%) for vimentin, and 4 (8%) for S100 protein. Monoclonal antibodies to Leu-7, desmin, neurofilament 200 kDa, and glial fibrillary acidic protein (GFAP) all failed to stain any of the 50 neoplasms. Overall, 34 (68%) meningiomas stained with one or more antibodies. Sixteen (32%) failed to stain at all. The dual epithelial and mesenchymal nature of meningiomas is supported in this study. Applications to diagnostic surgical pathology and histogenetic implications are discussed.
D000911:Antibodies, Monoclonal; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism / Q000473:pathology*; D018396:Mucin-1; D010641:Phenotype; D009418:S100 Proteins / Q000032:analysis; D013194:Staining and Labeling; D014746:Vimentin / Q000032:analysis
D000911:Antibodies, Monoclonal; D008565:Membrane Proteins; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins