[Relation between gramicidin D and valinomycin-induced conductivity of lipid bilayer and cholesterol levels].
Kinetics of conductance and current-voltage characteristics (VACH) were studied on the bilayer lipid membranes from egg lecithin and cholesterol modified by gramicidin D and valinomycin. There were found significant changes of ionic channels conductance g, lifetime tau and non-linearity coefficient beta of VACH of modified membranes dependent on cholesterol content. In the region of high cholesterol concentrations, more than 20 mol%, there were observed abrupt changes of the ionic channels parameters: tau increased more than ten times, conductance decreased two times and beta greater than 0 in the whole region of electrolyte concentration.
D002784:Cholesterol / Q000378:metabolism*; D004553:Electric Conductivity; D006096:Gramicidin / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D014634:Valinomycin / Q000494:pharmacology*
D007473:Ion Channels; D008051:Lipid Bilayers; D006096:Gramicidin; D014634:Valinomycin; D002784:Cholesterol
Zavisimost' indutsirovannoĭ gramitsidinom D i valinomitsinom provodimosti lipidnogo bisloia ot soderzhaniia kholesterina.