Carboxypeptidase H-like immunoreactivity in the striatum of cats and monkeys.
The enzyme carboxypeptidase H was detected by immunohistochemistry in the striatum of adult cats and monkeys. Specific labelling was observed in the neuropil as well as in both medium-sized and large neuronal cell bodies. The distribution of neurons and neuropil expressing immunoreactivity to carboxypeptidase H was examined in relation to the pattern of immunoreactivity to the neuropeptides enkephalin and substance P. Carboxypeptidase H-like immunoreactivity was found both in zones rich and poor in immunostaining for the two peptides, but was usually denser in those striatal areas in which substance P-positive cell bodies are clustered (striosomes). The results further suggest a role for carboxypeptidase H in the metabolism of multiple neuropeptides in vivo.
D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000276:immunology / Q000378:metabolism*; D002415:Cats; D002421:Caudate Nucleus / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology*; D004745:Enkephalins / Q000378:metabolism; D007150:Immunohistochemistry; D008253:Macaca mulatta; D009474:Neurons / Q000201:enzymology; D013373:Substance P / Q000378:metabolism
D004745:Enkephalins; D013373:Substance P; D002268:Carboxypeptidases; D043423:Carboxypeptidase H