Lindane neurotoxic reaction in nonbullous congenital ichthyosiform erythroderma.
A 3-year-old boy with nonbullous congenital ichthyosiform erythroderma with a four-month history of scabies was treated with a single dose of lindane cream. In a 48-hour period, he developed nausea and vomiting and also suffered from an epileptiform convulsion and muscular spasms. Seventy-two hours after application of the cream, his blood lindane level was 54 ng/mL. Caution should be exercised when using lindane in patients with compromised epidermal barrier function.
D002675:Child, Preschool; D001556:Hexachlorocyclohexane / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007057:Ichthyosis / Q000151:congenital*; D008297:Male; D012532:Scabies / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*; D013035:Spasm / Q000139:chemically induced
D001556:Hexachlorocyclohexane