Antiviral effect of two aryl-oligopeptides, FR41565 and FR48217.
Macrophages from mice pretreated with two chemically synthesized immunostimulating aryl-oligopeptides, FR41565 and FR48217, inhibited the multiplication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in monkey Vero cells, and that of vesicular stomatitis virus (VSV) in murine L929 cells. In addition, the aryl-oligopeptides protected mice against a lethal HSV-1 infection. In particular, when treated with FR48217 at 6 mg/kg, all mice survived, whereas all control mice died from the HSV-1 infection.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D007372:Interferons / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D009842:Oligopeptides / Q000494:pharmacology / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development
D000998:Antiviral Agents; D009842:Oligopeptides; C047918:FR 48217; D007372:Interferons; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine