Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus.
Unlike in mouse and hamster, the thymus of rats or guinea pigs contains measurable amounts of substance P-like immunoreactivity (SP-LI), which, in a HPLC system, eluted as authentic SP or SP sulfoxide. Ontogenetic study showed that in rats the SP-LI content of the thymus increased up to 60 days from birth, and decreased thereafter. Capsaicin, but not 6-hydroxydopamine (6-OHDA) pretreatment completely depleted thymic SP-LI content in both newborn and adult rats. Animals treated with capsaicin as newborns, but not as adults, showed lower thymus weights as compared to controls. Rats pretreated with capsaicin as adults underwent partial time-dependent recovery of thymic SP-LI content. Somatostatin-like immunoreactivity (SST-LI) of rat thymus, eluting in part as authentic SST, was unaffected both by capsaicin or 6-OHDA pretreatment. Taken together, these findings demonstrate the existence of capsaicin-sensitive structures containing SP in the rat thymus. The possible function(s) that capsaicin-sensitive structures could exert in the thymus, among which a trophic action, mediated by the efferent function of sensory neurons, remain(s) to be established.
D000375:Aging / Q000378:metabolism; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D005260:Female; D006168:Guinea Pigs; D006892:Hydroxydopamines / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000032:analysis; D016627:Oxidopamine; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000032:analysis; D013045:Species Specificity; D013373:Substance P / Q000032:analysis*; D013950:Thymus Gland / Q000032:analysis* / Q000187:drug effects
D006892:Hydroxydopamines; D013373:Substance P; D013004:Somatostatin; D016627:Oxidopamine; D002211:Capsaicin; D009638:Norepinephrine