Multiple sclerosis: increased expression of interleukin-2 receptors on lymphocytes.
The percentage of interleukin-2-receptor-positive peripheral blood lymphocytes in MS patients was significantly higher in acute relapse than in remission or in controls. After stimulation by phytohemagglutinin, the expression of interleukin-2 receptor on peripheral blood lymphocytes of MS patients was within the range of healthy controls, implying no general impairment of receptor expression. These results confirm other evidence that there is a small population of activated T lymphocytes in acute relapse of MS.
D000328:Adult; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology; D010835:Phytohemagglutinins / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D015375:Receptors, Interleukin-2; D012008:Recurrence
D000911:Antibodies, Monoclonal; D004676:Myelin Basic Protein; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2