Comparison of two strains of avian infectious bronchitis virus for their interferon induction, viral growth and development of virus-neutralizing antibody in experimentally-infected chickens.
Two field strains of avian infectious bronchitis virus were tested in specific pathogen-free chickens for interferon induction, growth and stimulation of virus-neutralizing antibody. Both strains induced interferon in lungs and trachea and neither strain induced it in kidneys. Strain Kagoshima-34, isolated from the kidneys of a chicken that had died of nephrosis/nephritis, induced interferon earlier than Strain Tottori-2, which was isolated from the trachea of a chicken with respiratory disease. Virus growth was generally more prolonged with Kagoshima-34, especially in the kidneys, but Tottori-2 persisted longer in the lungs.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002642:Chick Embryo; D002645:Chickens; D003332:Coronaviridae / Q000276:immunology*; D003333:Coronaviridae Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D005347:Fibroblasts; D001351:Infectious bronchitis virus / Q000254:growth & development / Q000276:immunology*; D007372:Interferons / Q000096:biosynthesis*; D007668:Kidney / Q000382:microbiology; D008168:Lung / Q000276:immunology / Q000382:microbiology; D009500:Neutralization Tests; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D013047:Specific Pathogen-Free Organisms
D000914:Antibodies, Viral; D007372:Interferons