title: Morphometrical studies of erythrophagocytosis in the spleen.
abstract: The elimination of altered RBC was investigated morphometrically in the rat spleen by determination of the percentage of erythrophagosomes in macrophages. PHZ and diamide treated RBC led to a time dependent increase of the percentage of erythrophagosomes in comparison to normal spleens. The deformability of the target RBC was lowered as revealed by measurements with glass micropipettes. RBC-microvesicles and diamide treated RBC are primarily loaded with IgG and undergo a rapid elimination. PHZ-RBC and cells with a prolonged stay in the spleen are sequestrated by secondary mechanisms. Details of primary and secondary elimination are discussed.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000276:immunology*; D007074:Immunoglobulin G / Q000378:metabolism*; D008264:Macrophages / Q000648:ultrastructure; D010587:Phagocytosis; D051381:Rats; D013154:Spleen / Q000166:cytology*
chemical_list: D007074:Immunoglobulin G