Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes.
Cultured keratinocytes were used as allografts to treat 51 patients with chronic venous ulceration or rheumatoid ulcers unresponsive to all previous conventional treatments including split skin grafts. Although early epithelialization could be seen in the centre of some ulcers, a major effect appeared to be healing from the previously indolent edge. This treatment appears to provide some clinical benefit in healing of chronic ulceration.
D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications; D001458:Bandages; D001684:Biological Dressings; D002478:Cells, Cultured; D002908:Chronic Disease; D000078404:Epidermal Cells; D005260:Female; D006801:Humans; D007633:Keratins / Q000008:administration & dosage*; D007871:Leg Ulcer / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014689:Venous Insufficiency / Q000139:chemically induced
D007633:Keratins