title: Calcium channel current inactivation is selectively modulated by menthol.
abstract: The effect of menthol on Ca channel current inactivation was studied in identified Helix neurons. External application of menthol accelerated the Ca-dependent rapid phase of inactivation. Menthol restored a fast inactivation phase after the Ca-dependent inactivation had been removed by strongly buffering changes in intracellular free Ca or by using Ba ions as current carriers. The menthol-induced inactivation was unchanged by variations in intracellular free Ca. A sensitizing effect of menthol on Ca-dependent inactivation appeared unlikely. Instead the results indicate a modulating action of menthol on Ca inactivation.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D004553:Electric Conductivity; D005724:Ganglia / Q000378:metabolism; D006372:Helix, Snails; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008610:Menthol / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D007473:Ion Channels; D008610:Menthol; D004533:Egtazic Acid; D002118:Calcium