title: Cellular calcium metabolism in primary hypertension.
abstract: Several disturbances of cellular Ca2+ metabolism have been described in essential hypertension and in the spontaneously hypertensive rat. Possibly the elevation of intracellular free Ca2+ concentration in arterial smooth muscle cells is one important step in the pathogenesis of primary hypertension. In most studies a decreased energy-dependent Ca2+ transport has been proposed as a mechanism. However, disturbances in cellular Ca2+ metabolism, which can be exclusively ascribed to essential hypertension, have not yet been found. The cause of altered cellular Ca2+ transport in primary hypertension may either be a genetically determined defect of membrane transport or a still-unidentified humoral factor.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D007473:Ion Channels; D002118:Calcium