[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Density ratios of inward currents].
Correlations between densities of different types of inward currents in the somatic membrane of dorsal root ganglion neurons were studied in three age groups of rats (5-9 days, 45 days and 90 days postnatally). A linear dependence between the densities of high-threshold calcium and slow sodium currents was found. No correlation was observed between the densities of different inward currents in neurons with low-threshold calcium inward current. An inverse dependence was observed between the densities of transmembrane currents in cells having only two types of channels ("fast" sodium and high-threshold calcium ones). Neurons exhibiting slow TTX-resistant sodium and/or low-threshold calcium channels did not show inverse dependence between the densities of "fast" sodium and high-threshold calcium currents.
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000502:physiology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D012964:Sodium / Q000502:physiology*
D007473:Ion Channels; D012964:Sodium; D002118:Calcium
Izmenenie ionnykh mekhanizmov élektrovozbudimosti somaticheskoĭ membrany sensornykh neĭronov krys v ontogeneze. Sootnosheniia plotnosteĭ vkhodiashchikh tokov.