[Action of dextran-modified hyaluronidase in experimental silicosis].
Dextran-modified hyaluronidase was inhaled or intraperitoneally injected for 4 months to mice with silicosis. Stabilized hyaluronidase was shown to have a marked inhibitory effect on the development of lung fibrosis. Drug inhalation proved to be the most effective. An antifibrotic effect of dextran itself has been observed.
D000280:Administration, Inhalation; D000818:Animals; D003911:Dextrans; D004353:Drug Evaluation, Preclinical; D004795:Enzyme Stability / Q000187:drug effects; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012829:Silicosis / Q000188:drug therapy* / Q000473:pathology
D003911:Dextrans; C001543:lidase; D006821:Hyaluronoglucosaminidase
Deĭstvie pri éksperimental'nom silikoze gialuronidazy, modifitsirovannoĭ dekstranom.