[Immunochemical study of modified forms of L-asparaginase].
Certain catalytic and immunological properties of L-asparaginase modified by polyglucin were studied. It was shown that the modified forms of L-asparaginase maintained high catalytic activity (Km 0.80.10(-5)-1.89.10(-5) M) and at the same time appeared to be more resistant to inactivation under the effect of antibodies.
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001215:Asparaginase / Q000037:antagonists & inhibitors / Q000276:immunology / Q000493:pharmacokinetics*; D002384:Catalysis; D003911:Dextrans / Q000276:immunology / Q000493:pharmacokinetics; D004347:Drug Interactions; D004800:Enzymes, Immobilized / Q000037:antagonists & inhibitors / Q000276:immunology / Q000493:pharmacokinetics*; D004926:Escherichia coli / Q000201:enzymology; D007114:Immunization; D007120:Immunochemistry; D011817:Rabbits
D000906:Antibodies; D003911:Dextrans; D004800:Enzymes, Immobilized; D001215:Asparaginase
Immunokhimicheskoe izuchenie modifitsirovannykh form L-asparaginazy.