The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.
A cellular src (c-src) cDNA clone was isolated from a chicken embryonic brain cDNA library and characterized by DNA sequence analysis. Comparison with the published sequence of a chicken genomic c-src clone indicated that the brain cDNA clone contained an 18-base-pair insertion located between exons 3 and 4 of the c-src gene. The six amino acids encoded by the insertion caused an alteration in the electrophoretic mobility of the c-src gene product similar to that of the structurally distinct form of the src protein detected in neuronal cultures.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology; D002642:Chick Embryo; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification; D005796:Genes; D009474:Neurons / Q000201:enzymology*; D011494:Protein Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016392:Proto-Oncogene Proteins pp60(c-src); D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics*
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D004247:DNA; D011494:Protein Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)