Juvenile chronic myelogenous leukaemia: report of a case with an unusually long period of survival.
A case of juvenile chronic myelogenous leukaemia is presented. The clinical and haematological responses to courses of cytosine arabinoside, 6-mercaptopurine and prednisolone are described. Although there was some satisfactory response to the treatment and remission lasting over an unusually long period of time, the patient died of a rapidly progressive hypersplenism with severe sequestration of transfused blood and platelets. The nonaggressive and easily administered regimen of drugs described here is recommended for children with this disease where bone marrow transplant facilities are unavailable.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D006801:Humans; D006971:Hypersplenism / Q000209:etiology; D007223:Infant; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage
D003561:Cytarabine; D011239:Prednisolone; D015122:Mercaptopurine