title: A patch clamp study of the action of ethacyzine on the rapid inward sodium current in single rat heart muscle cells.
abstract: The effect of ethacyzine (a diethylamine analogue of ethmozine) on the rapid inward sodium current (INa) was studied in single rat ventricular muscle cells by a patch clamp technique. Extracellular application of 3 microM ethacyzine depressed the INa in a use-dependent fashion. Rest recovery from the use-dependent block by ethacyzine followed an exponential time course with a time constant of about 215 +/- 40 s (n = 4, mean +/- S.E.).
mesh_terms: D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D016293:Moricizine / Q000031:analogs & derivatives*; D009206:Myocardium / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D012964:Sodium