title: The proton pump ATPase of lysosomes and related organelles of the vacuolar apparatus.
abstract: In this review, I hope to achieve the following: (a) to document the presence of a lysosome-like proton pump ATPase in many different membrane systems of animal, plant and microbial origin; (b) to glean from the diverse data common characteristics of these ATPases, especially as regards their similarities and differences with mitochondrial-type F1F0 proton pump ATPases; and (c) to consider questions of synthesis and regulation of a cellular proton pump system with such a widespread distribution.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D003034:Coated Pits, Cell-Membrane / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D007473:Ion Channels / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology*; D009940:Organoids / Q000201:enzymology*; D010944:Plants / Q000201:enzymology; D006180:Proton-Translocating ATPases / Q000378:metabolism; D011522:Protons; D014617:Vacuoles / Q000201:enzymology*
chemical_list: D007473:Ion Channels; D011522:Protons; D000251:Adenosine Triphosphatases; D006180:Proton-Translocating ATPases