Cholecystokinin-like immunoreactivity occurs in ocular sensory neurons and partially co-localizes with substance P.
Based on immunohistochemical analysis of the trigeminal, superior cervical, ciliary and sphenopalatine ganglia and of the eye after sensory denervation and sympathectomy, cholecystokinin (CCK)-like immunoreactive nerves in the guinea pig eye derive from the trigeminal ganglion. Substance P (SP) also occurs in some ocular sensory neurons, suggesting the possible co-localization in this system of CCK- and SP-immunoreactivities. A double-labeling immunofluorescence technique stained 3 types of trigeminal cells and ocular nerve fibers: some immunoreactive for both peptides, some immunoreactive only for CCK and some immunoreactive only for SP.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D005123:Eye / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D005726:Ganglia, Parasympathetic / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D009412:Nerve Fibers / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D012844:Sincalide / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000378:metabolism*; D014276:Trigeminal Nerve / Q000378:metabolism*
D009479:Neuropeptides; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide; D012844:Sincalide