title: Damage of porcine aortic valve tissue caused by the surfactant sodiumdodecylsulphate.
abstract: The Hancock T6 treatment uses 1% sodiumdodecylsulphate (SDS) to prevent or delay calcification in porcine aortic or pericardial bioprostheses. In the current study fresh and glutaraldehyde fixed porcine aortic cusps were treated in 1% SDS. The hydrothermal stability, the histological and the electronmicroscopic appearance of the tissue were assessed and compared before and after treatment. The results suggest that the 1% SDS solution destroys the fresh material causing acellularity, extreme fragmentation and swelling of the collagen, together with a significant loss of hydrothermal stability. Glutaraldehyde fixation prior to SDS treatment seems to provide protection against the harmful effects of the 1% SDS, with only one exception on electronmicroscopic examination where foci of collagen degeneration were found.
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D006358:Hot Temperature; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D013552:Swine; D013997:Time Factors
chemical_list: D012967:Sodium Dodecyl Sulfate