[Induction of Ca2+ ion transport in human thrombocytes as affected by thyroid hormone receptors from malignant transformed cells].
The effect of thyroid hormone receptors isolated from normal and malignant cells on the induction of Ca2+ transport to platelets was studied. It is established that the receptor isolated from malignant cells by thyroxin (T4) or triiodothyronine (T3) stimulates (three-fold) the induction of Ca2+ transport to platelets. The effect is blocked by verapamil, which is the inhibitor of Ca2+ channels in plasma membranes. It is shown that neither the receptor of cancer cells, nor hormones (T3 or T4) influence the transport of Ca2+ to platelets without preliminary complexing. The hormone-receptor complex failed to affect the concentration of "cytoplasmic" Ca2+ in platelets analogous experimental conditions. It is suggested that the increased Ca2+ content in cancer cells can be partially attributed to the ability of thyroid hormone receptor of cancer cells to induce Ca2+ transport across the plasma membrane.
D000230:Adenocarcinoma / Q000032:analysis; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006367:HeLa Cells / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D007473:Ion Channels; D009369:Neoplasms / Q000032:analysis*; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000032:analysis; D013963:Thyroid Hormones / Q000378:metabolism*
D007473:Ion Channels; D011956:Receptors, Cell Surface; D013963:Thyroid Hormones; D002118:Calcium
Induktsiia transporta ionov Ca2+ v trombotsitakh cheloveka pod deĭstvie retseptora tireoidnykh gormonov zlokachestvenno transformirovannykh kletok.