title: Localization and treatment of familial malignant nonfunctional paraganglioma with iodine-131 MIBG: report of two cases.
abstract: Two cases of familial, malignant, nonfunctional paraganglioma are reported. Uptake of iodine-131 metaiodobenzylguanidine ([131I]MIBG) by the tumors and metastases was demonstrated. In the first case, with multicentric and locally invasive disease, [131I]MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. In the second case, with widespread, symptomatic metastatic disease, a therapeutic dose of [131I]MIBG produced palliation of bone pain after the failure of radio- and chemotherapy. Uptake of [131I]MIBG by paragangliomas does not correlate with catecholamine secretory activity. Iodine-131 MIBG should be considered as a therapeutic option in unresectable, malignant paragangliomas which take up this radiopharmaceutical.
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000628:therapy; D002344:Carotid Body / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007462:Iodobenzenes / Q000627:therapeutic use; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010166:Palliative Care; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000628:therapy; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine