[Effect of 5-azacytidine on the frequency of polycentric chromosomes in cells with micronuclei during exposure to 5-bromodeoxyuridine].
Telomeric fusion of metaphase chromosomes was studied in conditions of DNA hypomethylation induced with 5-azacytidine. It was shown that the increased number of dicentric chromosomes was statistically significant in experiments when 5-azacytidine was used together with colcemid and 5-bromodeoxyuridine. These data demonstrate that DNA hypomethylation plays an important role in the manifestation of this phenomenon.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D004247:DNA / Q000187:drug effects; D003703:Demecolcine / Q000494:pharmacology; D066298:In Vitro Techniques; D008677:Metaphase
D004247:DNA; D001973:Bromodeoxyuridine; D001374:Azacitidine; D003703:Demecolcine
Vliianie 5-azatsitidina na chastotu politsentricheskikh khromosom v kletkakh s mikroiadrami pri vozdeĭstvii 5-bromdezoksiuridina.