title: [A model of the secondary structure and distribution of antigenic determinants in the VP1 protein of hepatitis A virus].
abstract: A comparative analysis of amino acid sequence of the proteins VP1 of hepatitis A virus and poliovirus of the 1 type was carried out. A model is proposed of structural organization of VP1 of hepatitis A virus providing the presence of a bilayer core formed by 8 antiparallel beta-strands. Probable candidates for surface antigenic determinants are the amino acid sequences located in unordered fragments of the polypeptide chain (residues 101-106 and 115-125), and alpha-helical region (residues 127-135).
mesh_terms: D002213:Capsid / Q000032:analysis* / Q000276:immunology; D036022:Capsid Proteins; D000939:Epitopes / Q000032:analysis*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D017955:Poliovirus / Q000276:immunology*; D011487:Protein Conformation
chemical_list: D036022:Capsid Proteins; D000939:Epitopes; C442540:VP1 protein, Poliovirus
vernacular_title: Model' vtorichnoĭ struktury i raspredeleniia antigennykh determinant v belke VP1 virusa gepatita A.