Beta human chorionic gonadotropin levels in cul-de-sac blood of patients with ectopic pregnancies.
hCG levels in cul-de-sac and peripheral blood in patients with ectopic pregnancies were studied. hCG levels were significantly higher in the cul-de-sac blood than in peripheral blood (P less than 0.01). The high hCG level in the cul-de-sac blood was not due to interference by proteolytic enzymes in cul-de-sac blood since the protease inhibitors, aprotinin and phenylmethylsulfony fluoride, did not alter the RIA results from cul-de-sac samples, nor did Con-A chromatography of the samples. Assay of cul-de-sac blood samples for hCG may increase the sensitivity of diagnosing ectopic pregnancies.
D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood*; D011863:Radioimmunoassay; D012039:Regional Blood Flow
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments