Potassium-induced histamine release from mast cells and its inhibition by ketotifen.
Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 mM in the absence of extracellular Ca2+. Potassium concentrations greater than 150 mM produced less histamine release. The release was energy-dependent and was complete within one minute. The histamine liberating effect of KCl could be inhibited by NaCl and by preincubation with ketotifen. The monovalent cations, Rb+ and Cs+ also evoked histamine release, whereas Na+ and Li+ were ineffective.
D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D011189:Potassium Chloride / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D011189:Potassium Chloride; D007665:Ketotifen