The effect of tachykinins on the conducting airways of the rat.
We studied the bronchial effects of intravenously administered tachykinins in inbred rats. Substance P and related tachykinins caused a dose-dependent bronchoconstriction. The bronchial reactivity to substance P differed significantly between different inbred rat strains. Substance K, eledoisin and kassinin were more potent than substance P in causing bronchoconstriction. This suggests a predominance in the bronchi of SP-E receptors. The bronchial effects of substance P and eledoisin were largely inhibited by atropine and slightly enhanced by hexamethonium. In addition to a direct effect on airway smooth muscle, tachykinins interfere with the cholinergic airway innervation of the rat at the ganglionic and postganglionic level.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D004558:Electric Stimulation; D005768:Gastrointestinal Hormones / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D007705:Kinins / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D007705:Kinins; D013373:Substance P; D001285:Atropine