Preservation of resuspended red cell concentrate. Metabolism and survival rate of stored red cells.
The sucrose-poor, electrolyte-rich SAG-sucrose preservation solution for red cell concentrates (RCC) proves to be superior to the sucrose-rich electrolyte-poor CDS-AG solution. After 35 days about 50% of the initial ATP were found and the 24 hours posttransfusion survival rate amounted to 76%. The replacement of sucrose by mannitol or sorbitol did not influence the metabolism of red cells. Guanosine-final concentration 0.4 mmol/l RCC-slightly improved the maintenance of ATP and morphology.
D000255:Adenosine Triphosphate / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001793:Blood Preservation / Q000379:methods*; D004905:Erythrocyte Aging / Q000187:drug effects; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D013395:Sucrose / Q000494:pharmacology
D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid; D013395:Sucrose; D000255:Adenosine Triphosphate