Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin.
A case of polyhydramnios associated with a ring chromosome is described. The condition was also associated with a low maternal serum alpha-fetoprotein level. The polyhydramnios was managed by initial therapeutic amniotic fluid decompression followed by indomethacin, which reduced fetal urine output and prevented reaccumulation of polyhydramnios.
D002869:Chromosome Aberrations; D005260:Female; D005333:Fetus / Q000502:physiology; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000150:complications / Q000188:drug therapy; D006831:Polyhydramnios / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D012303:Ring Chromosomes; D014556:Urine; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D007213:Indomethacin