Effects of exercise on bleomycin-induced pulmonary toxicity in mice.
NIH/Swiss mice were used to study the effects of exercise on bleomycin-induced pulmonary toxicity. After a 2-week exercise acclimation program the mice were treated with bleomycin sc twice a week and swim-exercised for 1 hour three times a week for 6 weeks. Based on higher mortality and significant weight loss in the exercise-drug-treated mice and a comparison of histological data, it is concluded that exercise exacerbates the toxicity of bleomycin.
D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D005082:Physical Exertion; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D001761:Bleomycin