Immunologic studies in asymptomatic hemophiliac patients.
Various immunological parameters were studied in 20 asymptomatic patients with hemophilia A, 3 patients with hemophilia B and 1 patient with von Willebrand disease. Patients were treated with cryoprecipitate or fresh frozen plasma. Significantly decreased mean percentage and absolute count (p less than 0.01) of peripheral blood E-rosette-forming cells compared to controls was found. There were normal mean percentages and absolute counts of lymphocytes, T-helper inducer, T-suppressor cytotoxic and natural killer cells. The proportion and absolute number of B cells was slightly increased. Significantly decreased natural killer cell activity (p = 0.02) of peripheral blood lymphocytes was observed. Our results indicate that asymptomatic patients with hemophilia may have early evidence of immunodeficiency.
D000293:Adolescent; D000328:Adult; D005164:Factor IX / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy / Q000276:immunology*; D002836:Hemophilia B / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification / Q000166:cytology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D014842:von Willebrand Diseases / Q000188:drug therapy / Q000276:immunology
D005169:Factor VIII; D005164:Factor IX