Lithium ion reversibly inhibits inducer-stimulated adipose conversion of 3T3-L1 cells.
Adipose conversion of 3T3-L1 cells by inducers (dexamethasone, 1-methyl-3-isobutylxanthine and insulin) was inhibited by LiCl at concentrations from 2 to 20 mM. The effect of LiCl was reversible and the inhibited cells were converted to adipocytes when stimulated after the removal of LiCl. Inhibition by LiCl of adipose conversion was accompanied with a blockage of the enhanced [3H]thymidine incorporation and cellular proliferation that occurred before the adipocyte phenotype was expressed. Of the cations tested, only Li+ had these effects.
D015056:1-Methyl-3-isobutylxanthine / Q000037:antagonists & inhibitors*; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002412:Cations / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002712:Chlorides / Q000494:pharmacology*; D003260:Contact Inhibition; D003907:Dexamethasone / Q000037:antagonists & inhibitors*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D007329:Insulin Antagonists / Q000494:pharmacology*; D050356:Lipid Metabolism; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D051379:Mice; D008985:Monensin / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives*
D002412:Cations; D002712:Chlorides; D007329:Insulin Antagonists; D000001:Calcimycin; D010042:Ouabain; D003907:Dexamethasone; D008985:Monensin; D008094:Lithium; D013806:Theophylline; D005993:Glycerolphosphate Dehydrogenase; D018021:Lithium Chloride; D015056:1-Methyl-3-isobutylxanthine