Effects of maitotoxin on ionic and secretory events in rat pancreatic islets.
Maitotoxin (MTX) provoked a dose-dependent increase in both 45Ca efflux and insulin release from rat pancreatic islets perifused in the presence or absence of glucose, provided that Ca2+ was present in the perifusate. The stimulatory effect of MTX on 45Ca outflow was enhanced by CGP 28392. The toxin did not reduce 86Rb outflow and 86Rb inflow. It is suggested that the secretory response to MTX is mediated by direct activation of voltage-dependent Ca2+ channels.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008387:Marine Toxins / Q000494:pharmacology*; D035964:Oxocins; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D000095702:Polyether Toxins
D002118:Calcium; D007328:Insulin; D007473:Ion Channels; D008387:Marine Toxins; D035964:Oxocins; D011725:Pyridines; C040525:CGP 28392; C020394:maitotoxin; D000095702:Polyether Toxins