Unusual "cytokine" activities of the random polymer (Glu60, Phe40) in murine immune systems.
When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led to augmentation of maximal incorporation of [3H]thymidine. The importance of the antigen presenting cells in these phenomena and the possible role of IL-1 in these observations will be documented.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D001688:Biological Products; D016207:Cytokines; D007107:Immune System / Q000187:drug effects*; D007375:Interleukin-1 / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000494:pharmacology*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011099:Polyglutamic Acid / Q000494:pharmacology*; D011108:Polymers; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D001688:Biological Products; D016207:Cytokines; D007375:Interleukin-1; D010455:Peptides; D011108:Polymers; D011099:Polyglutamic Acid; C023843:copolymer Glu(60)Phe(40); C044187:glutamic acid-lysine-alanine polymer; D010649:Phenylalanine