[Effects of nicotine on precocious evoked auditory potentials of the rat in the presence or absence of endogenous serotonin].
In the rat, nicotine bitartrate (100 micrograms/kg) by intraperitoneal route provokes modifications of the brain stem auditory evoked potentials. These changes are complex: a) decrease of the amplitude of waves IV and V, probably by fixation on nicotinic type receptors, neuronal serotonin stores being normal; b) increase of the amplitude of waves I, I' and II, more important when endogenous stores are depleted; c) increase in the latency of these waves when serotonin stores are normal.
D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*
D012701:Serotonin; D009538:Nicotine; D010424:Pentobarbital; D010134:Fenclonine
Effets de la nicotine sur les potentiels évoqués auditifs précoces du rat, en présence ou en l'absence de sérotonine endogène.