A peplomycin-supersensitive cell line lacking activation of poly(adenosine diphosphate ribose) synthetase by peplomycin.
In peplomycin-supersensitive Chinese hamster lung cells, the increase in poly(ADP-ribose) synthesizing activity following peplomycin treatment was significantly reduced as compared with the parental lung cells, suggesting that peplomycin-supersensitive lung cells may have some deficiency in DNA repair. On the contrary, peplomycin-supersensitive ovary cells, which undergo increased DNA damage induced by peplomycin, showed normally increased poly(ADP-ribose) polymerizing activity compared with the parental ovary cells. Relationship between poly(ADP-ribose) polymerase and peplomycin sensitivity was discussed.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004789:Enzyme Activation; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D017663:Peplomycin; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
D001761:Bleomycin; D017663:Peplomycin; D011065:Poly(ADP-ribose) Polymerases