title: Differential influences of different stressors upon midbrain raphe neurons in rats.
abstract: Various types of stressors were given to different groups of animals to examine their effects on the mesostriatal and mesolimbic serotonergic pathways. Results indicate that shock-induced fighting experience preferentially decreased serotonin (5-HT) levels in the dorsal raphe and striatum, while air puff stimulation selectively lowered 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) contents in the median raphe and hippocampus. Both immobilization and light footshock stress have a more consistent effect on both serotonergic systems. These results suggest that different stressors have differential influences upon central 5-HT neurons and, other than anatomical differentiation, these serotonergic neurons are not homogeneous with respect to their responses to stress either.
mesh_terms: D000374:Aggression / Q000502:physiology; D000818:Animals; D004597:Electroshock; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007103:Immobilization; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010812:Physical Stimulation; D011903:Raphe Nuclei / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid