title: Remyelination by oligodendrocytes stimulated by antiserum to spinal cord.
abstract: The new synthesis of myelin and the proliferation of oligodendrocytes was stimulated by serum from syngeneic mice immunized with homogenized spinal cord (SCH). Treatment with this antiserum produced a 10-fold increase in the area of remyelination in spinal cords that had become demyelinated previously as a result of infection by Theiler's murine encephalomyelitis virus. Inflammation was decreased in regions of white matter that showed remyelination. Oligodendrocytes exposed to anti-SCH in vitro incorporated three to five times more [3H]thymidine than resting cells did and expressed more myelin basic protein in their cytoplasm, suggesting stimulation of myelinogenesis. Thus, there is a factor present in anti-SCH antiserum that stimulates central nervous system-type remyelination. This finding may provide clues for the therapy of patients with demyelinating disorders such as multiple sclerosis.
mesh_terms: D000818:Animals; D002455:Cell Division; D003711:Demyelinating Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005455:Fluorescent Antibody Technique; D007116:Immunization, Passive; D004680:Maus Elberfeld virus / Q000276:immunology; D051379:Mice; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D004676:Myelin Basic Protein / Q000096:biosynthesis; D009185:Myelin Proteins / Q000096:biosynthesis*; D009186:Myelin Sheath / Q000378:metabolism* / Q000473:pathology; D009457:Neuroglia / Q000473:pathology*; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology*; D013116:Spinal Cord / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D013936:Thymidine / Q000378:metabolism
chemical_list: D004676:Myelin Basic Protein; D009185:Myelin Proteins; D013936:Thymidine