title: Cyclization of peptides on a solid support. Application to cyclic analogs of substance P.
abstract: The general conditions for cyclization of peptides on polymer matrix by disulfide bridge formation are reported. This procedure is based on attack of 3-nitro-2-pyridinesulfenyl group (Npys) by a thiol function. It has been used for synthesis of five cyclic analogs of Substance P.
mesh_terms: D000595:Amino Acid Sequence; D007202:Indicators and Reagents; D009904:Optical Rotation; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D010456:Peptides, Cyclic; D013373:Substance P