[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Distribution of ion channels of the inward current].
Distribution of different types of ionic channels carrying inward currents was studied in the somatic membrane of rat dorsal root ganglion neurons within three age groups: 5-9 days, 45 days and 90 postnatally. The number of neurons whose membrane contained simultaneously four types of inward current channels ("fast" tetrodotoxin-sensitive and "slow" tetrodotoxin-resistant sodium low- and high-threshold calcium one's) was progressively reduced in successive groups. The first group contained 14.5%, the second 5% and the third group 1% of such neurons. These changes were due to disappearance of "slow" sodium and low-threshold calcium channels from the membrane; the number of neurons whose somatic membrane contained only two types of inward current channels ("fast" sodium and high-threshold calcium) has increased, respectively.
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000502:physiology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D012964:Sodium / Q000502:physiology*
D007473:Ion Channels; D012964:Sodium; D002118:Calcium
Izmenenie ionnykh mekhanizmov élektrovozbudimosti somaticheskoĭ membrany sensornykh neĭronov krys v ontogeneze. Raspredelenie ionnykh kanalov vkhodiashchego toka.