Effect of glucose on antiviral activity of interferon.
Glucose was found to impair the antiviral activity of rabbit interferon (IFN) in RK-13 cells. This impairment was dependent on the glucose concentration: A pronounced impairment was observed at the concentration of 30 mg of glucose/ml, the maximum concentration which produced neither morphological changes of cells nor diminution of overall macromolecular synthesis. Maximal impairment was seen when glucose was added to the IFN-treated RK-13 cells early during the development of antiviral activity. Furthermore, glucose decreased the extent of induction of 2',5'-oligoadenylate synthetase by IFN. Of six different monosaccharides examined, only fructose had the same anti-IFN effect as glucose.
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis; D000818:Animals; D002460:Cell Line; D003864:Depression, Chemical; D004790:Enzyme Induction / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D007372:Interferons / Q000037:antagonists & inhibitors*; D007668:Kidney; D009005:Monosaccharides / Q000494:pharmacology; D011817:Rabbits; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000502:physiology
D009005:Monosaccharides; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase; D005947:Glucose