title: Therapeutic implications of sodium abnormalities in hypertension.
abstract: Abnormalities in cellular sodium transport have been demonstrated in leukocytes and erythrocytes of some patients with essential hypertension. Some patients with essential hypertension retain more sodium on a high-salt diet, despite an accompanying increase in pressure. Some epidemiological studies suggest a relationship between dietary sodium intake and essential hypertension. The biological significance of these findings remains uncertain. There is too little evidence to support dietary sodium restriction as a primary preventive measure in essential hypertension. Restriction of dietary intake of sodium to 80 mmol/day results in a reduction in blood pressure in a minority of patients with essential hypertension.
mesh_terms: D000375:Aging / Q000378:metabolism; D001692:Biological Transport; D001808:Blood Vessels / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000209:etiology / Q000628:therapy*; D007473:Ion Channels / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D012306:Risk; D012964:Sodium / Q000493:pharmacokinetics*
chemical_list: D007473:Ion Channels; D012964:Sodium