Cyclization of peptides on a solid support. Application to cyclic analogs of substance P.
The general conditions for cyclization of peptides on polymer matrix by disulfide bridge formation are reported. This procedure is based on attack of 3-nitro-2-pyridinesulfenyl group (Npys) by a thiol function. It has been used for synthesis of five cyclic analogs of Substance P.
D000595:Amino Acid Sequence; D007202:Indicators and Reagents; D009904:Optical Rotation; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D010456:Peptides, Cyclic; D013373:Substance P