Acute phase protein changes in antigen-induced mono-articular arthritis in rabbits and mice.
Acute phase protein levels have been measured during the induction and progression of antigen-induced mono-articular arthritis in rabbits and mice. In rabbits there was a short lived elevation in serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) immediately following intra-articular injection which returned to baseline levels 10-12 days after the injection. In BALB/c mice, serum amyloid P-component (SAP) and the third component of complement (C3) were elevated after intra-articular injection, returning towards baseline levels 6 weeks after the injection. The levels of CRP and SAP correlated with the inflammatory changes in the joints during the acute phase of the arthritic response (7 days after intra-articular injection). During the chronic phase the levels of these acute phase proteins bore no relationship to the degree of connective tissue destruction.
D000209:Acute-Phase Proteins / Q000097:blood*; D000818:Animals; D001168:Arthritis / Q000097:blood* / Q000209:etiology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D011817:Rabbits; D000683:Serum Amyloid P-Component / Q000097:blood
D000209:Acute-Phase Proteins; D003176:Complement C3; D000683:Serum Amyloid P-Component; D010047:Ovalbumin; D002097:C-Reactive Protein