[Physico-chemical and biological properties of a new plasma substitute based on hydroxyethylated starch].
Samples of hydroxyethylstarch of M 100-160 kDa, Mn 50-60 kDa and substitution degree 0.6-0.7 were prepared and characterized. Hydroxyethylstarch was shown to be susceptible to cleavage by amylolytic enzymes. All samples of hydroxyethylstarch at 2-4% concentration were compatible with perfluorohydrocarbon emulsion "Perftoran" and exhibited high haemodynamic efficiency. The 6 and 10% solutions of hydroxyethylstarch in 0.9% aqueous sodium chloride normalized haemodynamics in massive blood losses. Hydroxyethylstarch was completely removed from blood-stream. The preparations were shown to be nontoxic.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005466:Fluorocarbons / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000032:analysis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010952:Plasma Substitutes / Q000032:analysis* / Q000494:pharmacology; D013213:Starch / Q000031:analogs & derivatives*
D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D013213:Starch
Fiziko-khimicheskie i biologicheskie svoĭstva novogo plazmozamenitelia na osnove oksiétilirovannogo krakhmala.