Effect of human fibrin adhesive on the ear. An electrophysiological study of auditory function in the guinea pig correlated to light and electron microscopy of middle ear mucosa and inner ear structures.
The effect of human fibrin adhesive applied to the middle ear has been studied in guinea pig. Auditory function was measured using acoustically evoked brainstem responses. Middle and inner ear structures were studied with light, transmission and scanning electron microscopy. A transitory conductive hearing loss was observed, but after 8 weeks the auditory function appeared normal. Microscopy of the middle and inner ear failed to show any tissue damage.
D000818:Animals; D007611:Aprotinin / Q000633:toxicity*; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000187:drug effects; D001933:Brain Stem / Q000502:physiology; D004338:Drug Combinations / Q000633:toxicity; D007758:Ear, Inner / Q000187:drug effects* / Q000648:ultrastructure; D004432:Ear, Middle / Q000187:drug effects* / Q000648:ultrastructure; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005176:Factor XIII / Q000633:toxicity*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000633:toxicity*; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000187:drug effects / Q000648:ultrastructure; D011930:Reaction Time / Q000187:drug effects; D013917:Thrombin / Q000633:toxicity*; D014014:Tissue Adhesives / Q000633:toxicity*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin