[Normalizing effect of interferon on the system of mixed-function oxidases in the liver of mice with Lewis lung carcinoma].
The effect of interferon (IF) on the activity of multipurpose hepatic oxidases (MHO) in animals in the process of metastatic tumour development as well as interaction of IF and vinblastine (VBL) in the cell culture have been studied. IF activates MHO under conditions of their inhibition at the beginning of the tumour development and inhibits them to the normal level under activation in the postmetastatic period. Contrary to the data obtained in vivo IF does not decrease the toxicity of VBL for the tumour cells in vitro. The data obtained evidence for the modulating effect of IF on the MHO system under the tumour development.
D000818:Animals; D004789:Enzyme Activation; D007372:Interferons / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014747:Vinblastine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology
D014747:Vinblastine; D007372:Interferons; D006899:Mixed Function Oxygenases
Normaliziruiushchee deĭstvie interferona na sistemu mnogotselevykh oksidaz pecheni mysheĭ s kartsinomoĭ legkogo L'iuis.