title: Optimal flow of aorta-pulmonary artery shunt in patients with cyanotic heart disease.
abstract: An aorta-pulmonary artery shunt with an expanded polytetrafluoroethylene (Gore-Tex) tube graft (3 to 6 mm in diameter) was done in 33 cyanotic patients with complex congenital heart disease. The patients ranged from 14 days to 22 years old. In 28, the shunt flow (QB) was measured, and the optimal QB and graft size were determined. Nine patients had severe heart failure because of an excessively large shunt. Seven of these patients died, 5 early and 2 late after operation. The QBS in these 9 patients were extremely high; the QB index and the ratio of shunt flow to systemic flow (QB/QS) were 3.86 +/- 0.91 L/min/m2 (mean +/- standard deviation) and 52.4 +/- 9.7%, respectively. The QB index and the QB/QS of patients without severe cardiac failure were 1.49 +/- 0.92 L/min/m2 and 27.2 +/- 11.4%, respectively. In conclusion, the QB index, the QB/QS, or both should be maintained in the range of 1.6 to 2.4 L/min/m2 and 30 to 40%, respectively. In infants, however, it is advisable to control the flow at less than the range just given. Analysis of graft size in relation to body weight (BW, in kilograms) and body surface area (BSA, in square meters) showed that the optimal diameter (D, in millimeters) could be calculated by the following formulas: D = 1.88 In(BW) + 1.8 (r = .86) D = 0.87 In(BSA) + 5.3 (r = .73).
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003326:Coronary Circulation; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008297:Male; D010166:Palliative Care / Q000379:methods; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000209:etiology; D011651:Pulmonary Artery / Q000601:surgery*; D011652:Pulmonary Circulation
chemical_list: D011138:Polytetrafluoroethylene