T cell derived IgE binding factors inhibit IgE-specific rosettes on basophilic leukaemic cells and lymphocytes.
T cell derived IgE-binding factors inhibited the formation of IgE-specific rosettes on both rat basophilic leukaemic cells and lymphocytes. This was demonstrated by IgE-binding factors released from either IgE-pulsed T cells or adherent cells as well as from IgE-binding factor producing hybridomas. The different binding factors inhibited the IgE-rosettes to a different degree when tested on basophils and lymphocytes, most likely due to the higher affinity for IgE of the former cell type. The results indicate that rat basophils and mouse T cells may recognize common epitopes on the Fc portion of IgE.
D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D002460:Cell Line; D000939:Epitopes; D006825:Hybridomas / Q000276:immunology / Q000378:metabolism; D007942:Leukemia, Experimental / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D008222:Lymphokines / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D029584:Prostatic Secretory Proteins; D051381:Rats; D011961:Receptors, Fc / Q000276:immunology; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D000939:Epitopes; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors