[The influence of immunomodulators on lymphokine secretion of radiation-damaged lymphocytes].
Spleen lymphocytes derived from guinea pigs loose their ability to secrete lymphokines induced by Con A after treatment with irradiation (500 and 750 mC/kg). In the presence of the immunomodulator isoprinosine, levamisole and the thymosine-like factor TFX the lymphocytes are again capable of secreting lymphokines. After treatment with isoprinosine, levamisole and TFX in dosages between 10 and 100 micrograms/ml the migration inhibition activity for macrophages and the chemotactic activity for polymorphonuclear granulocytes produced by lymphocytes were restored.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003470:Culture Media / Q000032:analysis; D006168:Guinea Pigs; D007542:Inosine Pranobex / Q000494:pharmacology; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D007978:Levamisole / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*; D008222:Lymphokines / Q000096:biosynthesis / Q000378:metabolism* / Q000528:radiation effects; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D013154:Spleen / Q000166:cytology; D013949:Thymus Extracts / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D003470:Culture Media; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; C019108:TFX; D013949:Thymus Extracts; D003208:Concanavalin A; D007978:Levamisole; D007542:Inosine Pranobex
Der Einfluss von Immunmodulatoren auf die Lymphokinsekretion strahlengeschädigter Lymphozyten.