title: Effect of continuous infusion of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation.
abstract: The effect of the administration of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation was studied. Two equal-sized irradiation fractions were delivered with 1-, 7-, or 10-day intervals, with and without simultaneous administration of 40 mg bleomycin/kg in a continuous sc infusion, given over 7 days. In the experiments with irradiation only, the prolongation of the interval from 1 day to 7 days resulted in a net increase of the isoeffective dose due to compensatory proliferation. This effect was even more pronounced with the 10-day treatment interval. The addition of bleomycin, however, nearly completely suppressed this proliferative activity.
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008046:Lip; D051379:Mice; D009061:Mouth Mucosa / Q000187:drug effects / Q000528:radiation effects*
chemical_list: D001761:Bleomycin