Relationship between erythrocyte volume and count after experimental induction of anaemia in laboratory rats.
A significant correlation between MCV and RBCC in intact rats was discovered (r = -0.868, p much less than 0.001, slope = -6.756). Anaemia was induced and the changes in this relationship were studied. Slopes of regression lines (from +1.813 to -118.398) depended on the time which elapsed after strong PHZ-induced haemolytic event: first they changed to positive values, subsequently (during deepest anaemia) to the normal state and to more negative values during the recovery from anaemia. Emergence of MCV values from the regression curve began after weak haemolytic stress from repeated loading of PHE but the values observed did not exceed the prediction interval for individual MCVs.
D000740:Anemia / Q000097:blood* / Q000139:chemically induced; D000818:Animals; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D008297:Male; D010615:Phenacetin; D010659:Phenylhydrazines; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D013997:Time Factors
D010659:Phenylhydrazines; C030299:phenylhydrazine; D010615:Phenacetin