title: Molecular cloning of a protective antigen of schistosomes.
abstract: The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D006224:Cricetinae; D000939:Epitopes; D008970:Molecular Weight; D010215:Papio; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012547:Schistosoma / Q000276:immunology; D012550:Schistosoma mansoni / Q000235:genetics* / Q000276:immunology; D012552:Schistosomiasis / Q000517:prevention & control; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D013045:Species Specificity
chemical_list: D000947:Antigens, Helminth; D000954:Antigens, Surface; D000939:Epitopes; D011993:Recombinant Fusion Proteins