title: Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.
abstract: The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of antigen-antibody binding. The structure of the antigen changes on binding, and that of the antibody may also change; the interaction therefore has some of the character of a handshake.
mesh_terms: D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007135:Immunoglobulin Variable Region; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D009439:Neuraminidase / Q000276:immunology*; D009975:Orthomyxoviridae / Q000201:enzymology* / Q000276:immunology; D011487:Protein Conformation
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D007135:Immunoglobulin Variable Region; D046911:Macromolecular Substances; D009439:Neuraminidase