Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
The effects of 12 weeks of intravesical instillation of bleomycin, cisplatinum and picibanyl on development of urinary bladder tumors and preneoplastic lesions were examined in rats pretreated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for four weeks. Upon sacrifice at week 36, histopathological examination revealed a significantly reduced incidence of PN hyperplasia and a tendency for decreased papilloma generation in rats given cisplatinum. However, the other treatments were not associated with any effect on carcinogen-induced lesion development. The results demonstrate that cisplatinum has a potential for postinitiation inhibition of rat bladder carcinogenesis.
D000283:Administration, Intravesical; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D002945:Cisplatin / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D009602:Nitrosamines / Q000633:toxicity*; D010844:Picibanil / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D001688:Biological Products; D009602:Nitrosamines; D001761:Bleomycin; D002085:Butylhydroxybutylnitrosamine; D010844:Picibanil; D002945:Cisplatin