Irreversible circling behavior induced by a single systemic administration of pepleomycin in mice.
A single s.c. injection of 30 mg/kg of pepleomycin in mice produced an irreversible state of motor excitation and agitation from about 5 days after the injection, with the animals being very active and running around persistently (2-3 times/s). Abnormal movements persisted for the life of the animal without a further injection.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002491:Central Nervous System Agents / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D017663:Peplomycin; D012640:Seizures / Q000139:chemically induced; D013239:Stereotyped Behavior / Q000187:drug effects*
D002491:Central Nervous System Agents; D001761:Bleomycin; D017663:Peplomycin