Immunohistochemical demonstration of nociceptors in the capsule and synovial folds of human zygapophyseal joints.
Substance P, a physiologically potent neuropeptide, is considered to participate in nociceptive transmission of nerve impulses. Substance P immunofluorescent nerves are demonstrated in the inferior joint recess capsule and its synovial folds in human lumbosacral zygapophyseal joints. This may have clinical significance in spinal pain.
D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D007596:Joints / Q000294:innervation*; D008159:Lumbar Vertebrae / Q000294:innervation*; D009413:Nerve Fibers, Myelinated / Q000032:analysis / Q000033:anatomy & histology; D009619:Nociceptors / Q000033:anatomy & histology*; D012447:Sacrum / Q000294:innervation*; D013373:Substance P / Q000032:analysis; D013583:Synovial Membrane / Q000294:innervation*
D013373:Substance P