A role of oxidative DNA sugar damage in mutagenesis by neocarzinostatin and bleomycin.
The anti-tumor antibiotics neocarzinostatin and bleomycin specifically oxidize deoxyribose in DNA at the C-5' and C-4' positions, respectively. The resulting DNA lesions include strand breaks and apyrimidinic sites. Both agents are broad specificity mutagens, inducing, in various systems, base substitutions, frameshifts and deletions. Sequencing studies in bacterial systems have suggested that the base substitutions may result primarily from replicative bypass of the oxidized apyrimidinic sites.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001761:Bleomycin / Q000633:toxicity*; D004247:DNA / Q000378:metabolism*; D009153:Mutagens; D010084:Oxidation-Reduction; D009353:Zinostatin / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D009153:Mutagens; D001761:Bleomycin; D004247:DNA; D009353:Zinostatin