The action of a substance P antagonist on sympathetic nerve activity in the rat.
In anaesthetised rats recordings were made of sympathetic activity in renal nerves whilst studying the effects of intrathecal injection of the substance P antagonist (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-substance P on the responses to, stimulation of the ventrolateral medulla, to intrathecal injection of substance P, serotonin and glutamate. All responses were abolished by the antagonist.
D000818:Animals; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007278:Injections, Spinal; D007668:Kidney / Q000294:innervation*; D008526:Medulla Oblongata / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*
D005971:Glutamates; D012701:Serotonin; D013373:Substance P; D018698:Glutamic Acid; C038073:substance P, Arg(1)-Pro(2)-Trp(7),(9)-LeuNH(2)(11)-