Trigeminal origin of beta-preprotachykinin products in feline pial blood vessels.
A specific and sensitive radioimmunoassay measured the presence of immunoreactive neurokinin A within feline and human pial arteries. Immunoreactivity exhibited a retention time identical to that of synthetic peptide when acid extracts from feline and human blood vessels were subjected to reverse-phase high-performance liquid chromatography. As shown previously for substance P, levels of immunoreactive neurokinin A decreased significantly in the vessels from the ipsilateral rostral circle of Willis 19-24 days following unilateral trigeminal ganglionectomy. Hence, trigeminal projections to cerebral blood vessels contain both products of beta-preprotachykinin mRNA.
D000818:Animals; D001158:Arteries / Q000032:analysis / Q000294:innervation; D001921:Brain / Q000098:blood supply*; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015288:Neurokinin A; D009479:Neuropeptides / Q000032:analysis*; D010841:Pia Mater / Q000098:blood supply; D011863:Radioimmunoassay; D013373:Substance P / Q000032:analysis*; D014276:Trigeminal Nerve / Q000032:analysis*
D009479:Neuropeptides; D013373:Substance P; D015288:Neurokinin A