Effects of substance P and substance P antagonists on rat salivary secretion.
The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein and calcium levels obtained with substance P-induced salivary secretion for both glands were similar to those produced by acetylcholine stimulation and were not altered by the substance P analogues.
D000818:Animals; D002118:Calcium / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D008297:Male; D010306:Parotid Gland / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013363:Submandibular Gland / Q000378:metabolism; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D012471:Salivary Proteins and Peptides; D013373:Substance P; C042867:spantide; D002118:Calcium