Plasma level of dipropylacetamide and dipropylacetic acid and effect of these drugs on 5-hydroxytryptamine metabolism in mouse brain.
After intraperitoneal application of the antiepileptics dipropylacetamide (DPM, 200 mg/kg) and dipropylacetic acid (DPA, 200 mg/kg) in mice their concentration in plasma and their effects on 5-hydroxytryptamine (5-HT) metabolism in the brain were followed during 360 minutes. Peak plasma level of DPA and DPM was observed at 30 minutes, but level of DPM was only about 25% that of DPA. Plasma content of both drugs declined to low levels by 360 minutes. Both drugs increased brain content of the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA). After DPA application 5-HIAA level increased rapidly and had returned to control value by 360 minutes, while following DPM 5-HIAA increase was much more gradual and was more prolonged. Neither DPM nor DPA significantly altered brain 5-HT content. An apparent relationship between DPA plasma level and brain 5-HIAA content was observed while after DPM no association between plasma drug content and effect on cerebral 5-HT metabolism was seen.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D012701:Serotonin / Q000378:metabolism*; D014635:Valproic Acid / Q000031:analogs & derivatives / Q000097:blood* / Q000494:pharmacology
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014635:Valproic Acid; C004651:dipropylacetamide