title: No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.
abstract: Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubation with the maximum tolerated dose for 6 weeks. Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D003494:Cyclamates / Q000494:pharmacology* / Q000633:toxicity; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D014178:Translocation, Genetic / Q000187:drug effects*
chemical_list: D003494:Cyclamates