title: Elimination of bovine haptoglobin from rat circulation.
abstract: The rate of elimination from rat circulation of bovine or rat haptoglobin, of their complexes with homologous haemoglobin, and of preparations deprived of the terminal sialic acid (asialo-haptoglobin), was studied. The rate of elimination was identical for bovine haptoglobin and its complexes with bovine or rat haemoglobin (the half-life time, t1/2, was 10 h). The half-life time of complexes of rat haptoglobin with bovine or rat haemoglobin was about 2 h, and it was much shorter than t1/2 for rat haptoglobin (13 h). The shortest half-life time was observed for bovine and rat asialo-haptoglobin, 35 and 15 min, respectively. The elimination curves showed a biphasic or triphasic character, depending on the rate of elimination.
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006207:Half-Life; D006242:Haptoglobins / Q000378:metabolism / Q000493:pharmacokinetics*; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D006454:Hemoglobins