Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.
NMRI mice were treated with DFMO-bleomycin and DFMO-suramin drug combinations at day 8 post-inoculation. The highest percentage of parasitologically non patent mice were attained with DFMO-suramin combination treatments. Parasitological and serological examinations of the non-relapsing mice strongly suggests trypanosome clearance.
D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D013498:Suramin / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000662:veterinary*
D001761:Bleomycin; D013498:Suramin; D000518:Eflornithine