[Immunomodulating properties of immobilized terrilytin].
Terrilytin immobilized on dextran within 5-fold ranges of the preparation and antigen doses was used in the study. Its stimulating effect on development of humoral immune response to the T-dependent antigen was higher and more prolonged than that of the free enzyme. The stimulating effect of the immobilized and free terrilytin administered during development of the inductive phase of the immune response was more pronounced than that observed on injection of the preparations before immunization. The free and immobilized terrilytin had an analogous effect on development of delayed type hypersensitivity.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000287:Administration, Topical; D000681:Amylases / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D004800:Enzymes, Immobilized; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Izuchenie immunomoduliruiushchikh svoĭstv immobilizovannogo terrilitina.