Demonstration of alpha 2-adrenoceptor-mediated contraction in the isolated canine saphenous artery treated with Bay K 8644.
Contractions to B-HT 920 in the plantar branch of the canine saphenous artery in vitro occurred consistently only in the presence of the calcium channel agonist, Bay K 8644 (30 nM). These results indicate that prior activation of the calcium channel may be required to elicit a subsequent response to B-HT 920 in this artery. Furthermore, the contractile response was inhibited by rauwolscine (10 nM) and was unaffected by prazosin (10 nM), indicating that the response is mediated by postjunctional alpha 2-adrenoceptors.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000187:drug effects; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D011224:Prazosin