[Possibilities of prognosis in cancer of the transverse colon and rectum using CEA, AFP and immunoglobulins A, M and G].
Tumor antigens (CEA and AFP) were studied by radioimmunoassay and immunoglobulins A, M and G--after Mancini in blood plasma from 144 cases of colorectal cancer. In most patients, raised levels of CEA, AFP, IgA and IgG were identified. A 5-10-fold increase in CEA and AFP levels matched by a pronounced dysimmunoglobulinemia or IgG deficit (under 10 mg/ml) were prognostically unfavorable. If said shifts persist at days 25-30 after surgery, suspicion of inadequate removal of tumor, its occult dissemination and unfavorable prognosis is justified. Similarly inauspicious are concomitant low antigenic activity in tumor and IgC deficit or a marked dysimmunoglobulinemia. Therefore, a complex assay of tumor-associated antigens (CEA and AFP) and immunoglobulins A, M and G makes a contribution to evaluation of surgery, course of tumor progression and its prognosis.
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011863:Radioimmunoassay; D012004:Rectal Neoplasms / Q000175:diagnosis*; D000509:alpha-Fetoproteins / Q000032:analysis*
D002272:Carcinoembryonic Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D000509:alpha-Fetoproteins
Vozmozhnosti prognozirovaniia pri rake obodochnoĭ i priamoĭ kishki s pomoshch'iu REA, AFP i immunoglobulinov klassa A, M, G.