[Effect of thyroid hormones on the nuclear-cytoplasmic transport of RNA].
The regulation of gene expression by hormones can be implemented at different levels: mRNA transcription, processing, transport from the nucleus into the cytoplasm, and translation. In the authors' earlier papers it was shown that the thyroxin hormone-receptor complex (HRC) increased chromatin matrix activity and induced new sites of transcription initiation. The present work was concerned with a study of the role of the thyroxin HRC in the regulation of the mechanism of 3H-RNA transport from the nucleus into the cytoplasm. An idea of the involvement of the HRC cytoplasmic thyroxin in RNA transport resulted from the detection in 30-40 S of RNP particles from rat liver nuclear proteins similar to the thyroxin cytoplasmic receptor by the antigen determinants. These data combined with others on the stimulation of 3H-RNA discharge from isolated nuclei under the influence of the thyroxin cytoplasmic HRC led to a conclusion that the thyroxin cytoplasmic HRC was involved in the regulation of gene expression by the thyroid hormones not only at the stage of transcription but also at the post-transcription stage, namely at the stage of RNA nuclear-cytoplasmic transport.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000032:analysis; D003593:Cytoplasm / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D011988:Receptors, Thyroid Hormone; D012261:Ribonucleoproteins / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D011956:Receptors, Cell Surface; D011988:Receptors, Thyroid Hormone; D012261:Ribonucleoproteins; D012313:RNA; D013974:Thyroxine
Vliianie tireoidnykh gormonov na iaderno-tsitoplazmaticheskiĭ transport RNK.