Increased procollagenase activating angiogenic factor in the vitreous humour of oxygen treated kittens.
Previous studies have demonstrated an increase in a low molecular weight angiogenic factor (ESAF) present in the retinae of kittens with oxygen induced retinopathy. The present paper describes differences in the quantity of ESAF extracted from the vitreous humour of control and oxygen treated animals and proposes a mechanism for the induction of intravitreal neovascularisation.
D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D017364:Collagenases; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism*; D003012:Microbial Collagenase / Q000378:metabolism; D008970:Molecular Weight; D009389:Neovascularization, Pathologic / Q000209:etiology; D010100:Oxygen / Q000494:pharmacology*; D012160:Retina / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*
D043925:Angiogenesis Inducing Agents; D004792:Enzyme Precursors; D006133:Growth Substances; D017364:Collagenases; C022440:procollagenase; D003012:Microbial Collagenase; D010100:Oxygen