Increased vascular perfusion after administration of an omental lipid fraction.
Recently, it has been reported that a lipid material is present within the omentum which has potent angiogenic activity. In the report being presented herein, the omental material was injected intramuscularly in the area of a standardized wound and at a site distant from the wound. Control animals were injected in a comparable manner using saline solution. The omental lipid material resulted in increased vascular perfusion in the wound regardless of whether the material was injected locally or remotely as measured by in vivo nuclear imaging techniques using tagged erythrocytes labeled with Technetium (Tc-99m). The ability to demonstrate that an omental lipid fraction can cause increased vascular perfusion has become possible because the omental lipid material is abundant in supply and relatively simple to prepare in large quantities.
D043925:Angiogenesis Inducing Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004912:Erythrocytes; D006133:Growth Substances / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D008055:Lipids / Q000494:pharmacology*; D009389:Neovascularization, Pathologic; D009852:Omentum / Q000032:analysis*; D013667:Technetium; D014945:Wound Healing
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances; D008055:Lipids; D013667:Technetium