title: Three types of muscarinic conductance changes in sympathetic neurons discriminately evoked by the different concentrations of acetylcholine.
abstract: Three different types of changes in membrane conductance were induced in isolated mammalian sympathetic neurons by the muscarinic actions of acetylcholine at different levels of concentration. These include a voltage-independent increase and two decreases, voltage-dependent and -independent, respectively. Muscarinic receptors in sympathetic neurons are thus shown to be coupled to multiple ionic channels, even within a single cell, and controlled by the different concentrations of a neurotransmitter.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D007473:Ion Channels; D011976:Receptors, Muscarinic; D000109:Acetylcholine