title: [Effect of synthetic and natural inhibitors on the activity of tissue activator from the swine heart in vitro].
abstract: Activity of tissue activator, isolated from pig heart, was studied in vitro in presence of synthetic inhibitors epsilon-aminocapronic acid and amben as well as of natural inhibitor contrical. All the inhibitors studied inhibited the tissue activator as shown by analyses on fibrin plates and by means of quantitative estimation of thrombolytic activity in fibrinolytic preparations in vitro. Among the two synthetic inhibitors amben exhitited the highest effect on the tissue activator: its effect was 3-4-fold higher as compared with epsilon-aminocapronic acid.
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology; D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D005337:Fibrin; D066298:In Vitro Techniques; D009206:Myocardium / Q000032:analysis*; D010653:Phenylbutazone / Q000494:pharmacology; D013552:Swine; D013831:Thiamine / Q000494:pharmacology; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D014805:Vitamin B 12 / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D000632:Aminopyrine; D003907:Dexamethasone; C036446:aminopyrine, dexamethasone, phenylbutazone, thiamine, vitamin B12 drug combination; D005337:Fibrin; D007611:Aprotinin; D010959:Tissue Plasminogen Activator; D010653:Phenylbutazone; D014805:Vitamin B 12; D015119:Aminocaproic Acid; D013831:Thiamine
vernacular_title: Vliianie sinteticheskikh i prirodnykh inhibitorov na aktivnost' tkanevogo aktivatora iz serdtsa svin'i in vitro.