Selection of antigenic variants from Leptospira interrogans serovar canicola by means of anti-canicola monoclonal antibody.
Antigenic variants were isolated from canicola by a single selection with anti-canicola monoclonal antibody CT-3. The variants were not identical to any serovars of serogroup Canicola and thought to be a new serovar. Variation frequency was calculated at 5.9 X 10(-4). The usefulness of monoclonal antibodies for selection of antigenic variants of leptospiras is discussed.
D000372:Agglutination Tests; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000942:Antigens, Bacterial / Q000302:isolation & purification; D000939:Epitopes / Q000302:isolation & purification*; D007921:Leptospira interrogans / Q000145:classification / Q000276:immunology*; D007922:Leptospirosis / Q000276:immunology*; D012703:Serotyping
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000939:Epitopes