Enhancement of the cytogenetic efficacy of the antitumor agent bleomycin by the calcium and calmodulin antagonist fendiline.
The induction of chromosome aberrations (dicentric and ring chromosomes) in human lymphocytes by the antitumor agent bleomycin is synergistically enhanced when bleomycin is applied together with the calcium antagonist fendiline (Sensit).
D001761:Bleomycin / Q000008:administration & dosage*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005275:Fendiline / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects; D010627:Phenethylamines / Q000008:administration & dosage*
D010627:Phenethylamines; D001761:Bleomycin; D005275:Fendiline