title: In vivo effects of corticosteroids on human allergic responses. I. Effects of systemic administrations of steroids.
abstract: In order to better understand the effects of corticosteroids in allergic disease, the relative degrees of allergen-induced cutaneous histamine release and granulocyte accumulation were evaluated in atopic volunteers following intravenous placebo or methylprednisolone administration. In nine subjects, a single intravenous dose of methylprednisolone (1 mg/kg) did not inhibit histamine release but did significantly reduce granulocyte accumulation at both allergen and buffer-challenged sites during five and one-half to six and one-half hours following steroid injection. These findings suggest that the corticosteroid-induced anti-inflammatory effects at allergic reaction sites do not include inhibition of local mediator release. Furthermore, the steroid-induced inhibition of inflammatory cell accumulation is not specific for the allergic reaction.
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001491:Basophils / Q000187:drug effects; D004334:Drug Administration Schedule; D004804:Eosinophils; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007958:Leukocyte Count; D008214:Lymphocytes; D008407:Mast Cells / Q000187:drug effects; D008775:Methylprednisolone / Q000008:administration & dosage; D009504:Neutrophils
chemical_list: D000305:Adrenal Cortex Hormones; D008775:Methylprednisolone