Morphine activates calcium channels in cloned mouse neuroblastoma cell lines.
Membrane effects of morphine on cloned neuroblastoma cells (strains NG108-CC15 and N1E-115), were studied using intracellular recording and ion flux techniques. Morphine (10 microM) induced a depolarization that was affected by changes in the concentration of calcium, but not in sodium. Further, morphine induced an uptake of 45Ca2+ which was blocked by naloxone (1 microM). The simplest explanation for the findings is that morphine activates calcium channels via mu-receptors.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D002999:Clone Cells; D005910:Glioma; D006822:Hybrid Cells; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009447:Neuroblastoma; D051381:Rats
D007473:Ion Channels; D009020:Morphine; D002118:Calcium