title: [Intraclonal variability in the McA-RH 7777 hepatoma cell line detected by analytical cloning].
abstract: McA-RH 7777 hepatoma cell line has been cloned twice at a week's interval (analytical cloning). Alpha-fetoprotein (AFP) phenotypes of primary and secondary clones from 46 primary clones were analyzed. High interclonal variability exceeded the mutation rate by several orders. The interclonal differences have been also found in the variability rates.
mesh_terms: D000818:Animals; D002460:Cell Line; D002999:Clone Cells / Q000473:pathology; D014644:Genetic Variation; D008114:Liver Neoplasms, Experimental / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D010641:Phenotype; D051381:Rats; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000235:genetics
chemical_list: D000509:alpha-Fetoproteins
vernacular_title: Vnutriklonal'naia izmenchivost' v kletochnoĭ linii gepatomy McA-RH 7777, vyiavlemaia analiziruiushchim klonirovaniem.