[Nonspecific and antigen-specific adhesiveness of circulating lymphocytes in dysentery patients undergoing combined therapy using thymalin and indomethacin].
Nonspecific adhesiveness of lymphocytes to polyacrylonitrile fiber and the antigen-specific adhesiveness of T-lymphocytes to Shigella flexneri pellicular immunosorbent have been studied in dysentery patients. Short courses of treatment with indomethacin, but not with thymalin (the preparation of thymic hormones), used for immunomodulation, have accelerated the normalization of nonspecific lymphocyte adhesiveness during regression of the disease, while indomethacin, in contrast to thymalin, inhibits antigen-specific T-lymphocyte adhesiveness which increases with the development of immune response.
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D003131:Combined Modality Therapy; D003289:Convalescence; D004405:Dysentery, Bacillary / Q000276:immunology* / Q000628:therapy; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007163:Immunosorbent Techniques; D007213:Indomethacin / Q000627:therapeutic use*; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D012763:Shigella flexneri / Q000276:immunology; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D000939:Epitopes; D013951:Thymus Hormones; C032805:thymalin; D007213:Indomethacin
Nespetsificheskaia i antigenspetsificheskaia adgezivnost' tsirkuliruiushchikh limfotsitov u bol'nykh dizenterieĭ pri kompleksnoĭ terapii s primeneniem timalina i indometatsina.