title: Whipple's disease confined to the central nervous system.
abstract: Progressive hypersomnia, memory disturbance, and vertical ophthalmoplegia developed in a 63-year-old woman. The diagnosis of Whipple's disease of the central nervous system was suggested by her presentation and results of studies using magnetic resonance imaging. Despite a one-month course of antibiotics, active Whipple's disease, localized to the central nervous system, was found at autopsy.
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D008061:Whipple Disease / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000890:Anti-Infective Agents