Activation of the mas oncogene during transfection of monoblastic cell line DNA.
Using the tumorigenicity assay, we observed an activation of the mas oncogene during transfection of human acute myelocytic leukemia (CTV-2) DNA. Respective transfectants contained amplified mas sequences characterized by rearrangements in 5' and 3' noncoding regions that were transcribed into a 3.3 kb mas RNA species. Our data represent the second report on activation of the mas gene.
D000818:Animals; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051379:Mice; D008819:Mice, Nude; D009857:Oncogenes; D011061:Poly A / Q000032:analysis; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger; D014162:Transfection
D004273:DNA, Neoplasm; D012333:RNA, Messenger; D011061:Poly A; D012313:RNA; D004262:DNA Restriction Enzymes