title: [The blood coagulation system in progressive systemic scleroderma].
abstract: Twenty-five scleroderma patients have been studied to evaluate blood coagulative and fibrinolytic parameters. An increase in FVIII related activities and a reduction in fibrinolytic activity was observed. These changes may be related to the endothelial damage present scleroderma patients I the consequent "in loco" activation of blood coagulation may cause the microthrombosis that is very often observed in the earliest phases of the disease.
mesh_terms: D000328:Adult; D000941:Antigens / Q000032:analysis; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D012595:Scleroderma, Systemic / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D000941:Antigens; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; D014841:von Willebrand Factor; D005169:Factor VIII; D010958:Plasminogen
vernacular_title: Il sistema emocoagulativo nella sclerodermia sistemica progressiva.