Evaluation of the antihypertensive effect of a beta-blocker with the aid of daily blood pressure profiles.
The clinical efficacy of bopindolol, a new, long-acting beta-adrenoceptor blocking drug, in a dosage of 1-2 mg daily was compared with that of atenolol (50-100 mg daily) in 33 patients with mild or moderate arterial hypertension who were treated for a total period of 12 months. Both drugs lowered systolic and diastolic blood pressure to about the same extent, but atenolol caused a somewhat greater lowering of heart rate. Over 70% of patients receiving atenolol required a diuretic in addition, whereas only 55% of the bopindolol patients required a diuretic. Both drugs maintained 24-h blood pressure reduction with once-daily therapy, although circadian rhythm (recorded using a Remler device) tended to be lost during treatment with atenolol but not with bopindolol.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000031:analogs & derivatives / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D001262:Atenolol; D010869:Pindolol; C036007:bopindolol