Effect of niacin and niacin-tryptophan deficiency on pancreatic acinar cell function in rats in vitro.
To determine the effect of niacin deficiency on pancreas, rats were fed a standard rat chow ad libitum or an equal amount of a niacin-deficient or niacin-sufficient diet in the first experiment, or of a niacin-tryptophan-deficient or niacin-tryptophan-sufficient diet in the second experiment. Niacin deficiency decreased tissue chymotrypsinogen and trypsinogen content; amylase, chymotrypsinogen, and trypsinogen concentration; and basal secretion of total protein. Niacin-tryptophan deficiency decreased body weight, pancrease weight, and content of DNA, protein, amylase, lipase, chymotrypsinogen, and trypsinogen. Secretion of amylase and trypsinogen was increased. These studies indicate that niacin and niacin-tryptophan deficiency alter digestive-enzyme content and secretion, probably due to metabolic aberrations that result in an altered redox state of the acinar cell.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002919:Chymotrypsinogen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008297:Male; D009525:Niacin / Q000172:deficiency*; D009929:Organ Size; D010179:Pancreas / Q000201:enzymology* / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014362:Trypsinogen / Q000378:metabolism; D014364:Tryptophan / Q000172:deficiency*
D011506:Proteins; D009525:Niacin; D014364:Tryptophan; D014362:Trypsinogen; D004247:DNA; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases