[ATP level in synaptosomes--a determining factor of the functional activity of ion channels induced by alpha-latrotoxin].
The paper deals with characteristics of relationship between synaptosomal calcium permeability induced by alpha-latrotoxin and cytosolic concentration of ATP. It is shown that reagents decreasing the ATP level in the synaptosomes (monoiodoacetate, papaverine) inactivate the toxin-induced ionic fluxes and, on the contrary, reagents increasing the ATP level in synaptosomes enhance the toxin-induced calcium influx. The treatment of synaptosomes with inhibitors of phosphodiesterase of cAMP and cAMP-dependent protein kinase has no effect on the alpha-latrotoxin-induced calcium influx.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D013111:Spider Venoms / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism*
D001180:Arthropod Venoms; D007473:Ion Channels; D013111:Spider Venoms; D013386:Succinates; C020763:alpha-latrotoxin; D000255:Adenosine Triphosphate; D010208:Papaverine
Uroven' ATP v sinaptosomakh--opredeliaiushchiĭ faktor funktsional'noĭ aktivnosti ionnykh kanalov, indutsiruemykh alpha-latrotoksinom.