[Effect of a serum inhibitor on hematopoiesis regulation: in vitro effect on RNA synthesis in bone marrows of rats].
Hematopoiesis is regulated by several hormones and protein factors, among them, erytropoietin (Ep) and granulopoietin (CSF: Colony Stimulating Factor) play the fundamental control activities inducing the differentiation of stem cells to red and white cells series, respectively. The action of serum inhibitors and cyclic nucleotides on hematopoietic process is not well understood at present time. In this work a rat serum-inhibiting activity was detected that diminished the in vitro [3H] uridine incorporation into rat bone marrow whole RNA. The experiments show that the inhibitory may have a platelet origin.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D066298:In Vitro Techniques; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014529:Uridine / Q000378:metabolism
D003115:Colony-Stimulating Factors; D004921:Erythropoietin; D012313:RNA; D014529:Uridine
Acción de un inhibidor sérico en la regulación de la hematopoyesis: efecto in vitro sobre la síntesis de RNA en médula ósea de rata.