Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons.
In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002586:Cesium / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013779:Tetrodotoxin / Q000494:pharmacology
D007473:Ion Channels; D002586:Cesium; D013779:Tetrodotoxin; D008274:Magnesium; D002118:Calcium