Soman intoxication-induced increase in the levels of mRNAs coding for acute phase reactants.
The effect of lethal and repetitive sublethal soman intoxication on the composition of rat liver mRNA was examined by cell-free translation and hybridization. It was found that lethal as well as sustained sublethal soman poisoning of rats elicited a typical acute phase response as judged by a several-fold increase in levels of mRNAs coding for the major acute phase proteins and the vast number of systemic and metabolic changes creating the acute phase response should be taken into account when the metabolic events during the recovery from organophosphate intoxication are under consideration.
D000209:Acute-Phase Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D000210:Acute-Phase Reaction / Q000139:chemically induced; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009693:Nucleic Acid Hybridization; D010091:Oximes; D014176:Protein Biosynthesis; D011726:Pyridinium Compounds / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000235:genetics; D012999:Soman / Q000633:toxicity*; D014425:Turpentine / Q000633:toxicity
D000209:Acute-Phase Proteins; D000931:Antidotes; D010091:Oximes; D011726:Pyridinium Compounds; D012333:RNA, Messenger; D012709:Serum Albumin; D001285:Atropine; D012999:Soman; C022870:asoxime chloride; D014425:Turpentine