title: Heterotopic ossification with total hip endoprostheses in various models of thrombosis prophylaxis.
abstract: The influence of thrombosis prophylaxis on the occurrence of heterotopic ossification after implantation of total hip endoprostheses was analyzed in a series of randomized studies. When low-dose heparin or dextran 40 was administered, the rate of ossification was comparatively high (30.1% and 65.1%). When a combination of acetylsalicylic acid and an antirheumatic (oxyphenbutazone) or low-dose heparin with an antirheumatic (indomethacin) was administered, the ossification rate became significantly lower (6.2% and 16.7%). No severe ossification (Arcq degree III) was observed in the groups given an antirheumatic in addition to thrombosis prophylaxis.
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D001842:Bone and Bones; D002828:Choristoma / Q000209:etiology*; D003911:Dextrans / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006622:Hip Prosthesis; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D010113:Oxyphenbutazone / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D003911:Dextrans; D006493:Heparin; D010113:Oxyphenbutazone; D001241:Aspirin; D007213:Indomethacin