Genetic control of delayed-type hypersensitivity to D-penicillamine antigen.
For determining the mechanism of genetic control of D-penicillamine free-base-specific delayed-type hypersensitivity (DTH) in mice, footpad swelling response was employed. Studies with various congenic and recombinant inbred strains of mice revealed that D-penicillamine free-base-specific DTH was controlled by the I-A subregion. The footpad swelling response showed a highly antigen-specific pattern, and revealed that D-penicillamine free base was not cross-reactive with D-penicillamine disulfide or L-penicillamine, but with D-penicillamine HCl. Treatment of immune lymphoid cells with monoclonal antibodies plus complement revealed that the cells responsible for DTH transfer were Lyt-1+2-, L3T4+ and Ia-T cells.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000941:Antigens; D004342:Drug Hypersensitivity / Q000209:etiology*; D000939:Epitopes; D006968:Hypersensitivity, Delayed / Q000235:genetics*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D010396:Penicillamine / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens; D000939:Epitopes; D010396:Penicillamine