Selective depletion of cerebral norepinephrine with 6-hydroxydopamine and GBR-12909 in neonatal rat.
Specific and extensive neonatal depletions of norepinephrine were produced in 3-day-old rats by combined administration of GBR-12909 (40 mg/kg, i.p.), a specific inhibitor of dopamine uptake, and the neurotoxin 6-hydroxydopamine (125 micrograms, i.c.). Norepinephrine concentrations in prefrontal cortex and hippocampus were reduced by more than 95%, and hypothalamic concentrations were reduced by 57%. Concentrations of dopamine, serotonin, and their respective metabolites were not affected in these regions or in the striatum.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D005260:Female; D006719:Homovanillic Acid / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis*; D016627:Oxidopamine; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D006892:Hydroxydopamines; D010879:Piperazines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D016627:Oxidopamine; C043425:vanoxerine; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid