On the appearance of polyadenylate polymerase activity in blood serum of animals exposed to a short-term influence by N,N'-ethylenethiourea, a well known hepatic carcinogen: a preliminary report.
Daily intragastric administration of a carcinogen N,N'-ethylenethiourea (ETU) (85 mg/kg body wt, congruent to 0.1 DL50) leads to significant polyadenylate polymerase (PAP) activity in rat blood serum by the 10th day of experiment. A similar course of N,N'-ethyleneurea (EU) fails to affect this enzyme activity in the blood. Also, PAP activity is not registered in the blood serum of intact rats.
D000818:Animals; D005031:Ethylenethiourea / Q000633:toxicity*; D007093:Imidazoles / Q000633:toxicity*; D048289:Imidazolidines; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009713:Nucleotidyltransferases / Q000097:blood*; D011062:Polynucleotide Adenylyltransferase / Q000097:blood*; D051381:Rats; D000509:alpha-Fetoproteins / Q000032:analysis
D007093:Imidazoles; D048289:Imidazolidines; D000509:alpha-Fetoproteins; D005031:Ethylenethiourea; C004916:ethylene urea; D009713:Nucleotidyltransferases; D011062:Polynucleotide Adenylyltransferase