Detection of HTLV-III-specific IgG bands in the CSF from a patient with AIDS and encephalitis.
Recent evidence would suggest that HTLV-III may be neurotropic. We have found oligoclonal IgG bands by isoelectric focusing in the CSF of a homosexual man with AIDS and encephalitis. Subsequent analysis revealed that such bands contained anti-HTLV-III activity, suggesting that neurologic symptoms in AIDS patients may be caused by replication of HTLV-III inside the CNS.
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000150:complications; D000939:Epitopes; D006678:HIV / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid* / Q000276:immunology; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D043025:Oligoclonal Bands
D000939:Epitopes; D007136:Immunoglobulins; D043025:Oligoclonal Bands