Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells.
D001943:Breast Neoplasms / Q000201:enzymology*; D002460:Cell Line; D005492:Folic Acid / Q000378:metabolism / Q000494:pharmacology*; D005493:Folic Acid Antagonists; D006801:Humans; D007424:Intracellular Fluid / Q000032:analysis; D008727:Methotrexate / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
D005493:Folic Acid Antagonists; D009363:Neoplasm Proteins; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; C011864:7-hydroxymethotrexate; D008727:Methotrexate