Mechanism of smooth muscle contraction: relevance to safety of beta-adrenergic blockade in hypertensive patients with reversible chronic obstructive airways disease.
The phosphorylation hypothesis of smooth muscle contraction relates formation of cyclic AMP, resulting from beta-adrenergic stimulation, to inhibition of myosin light-chain phosphorylation and hence to bronchial relaxation. The hypothesis can therefore explain why beta-adrenergic blockade promotes bronchospasm in susceptible individuals. In the light of this molecular schema, various novel approaches to the use of beta-adrenergic blocking therapy for hypertension in the presence of asthma are discussed.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001980:Bronchi / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002147:Calmodulin / Q000378:metabolism; D017272:Celiprolol; D000242:Cyclic AMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007741:Labetalol / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008954:Models, Biological; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects*; D009218:Myosins / Q000378:metabolism; D010766:Phosphorylation; D011412:Propanolamines / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D002147:Calmodulin; D011412:Propanolamines; D001262:Atenolol; D017272:Celiprolol; D000242:Cyclic AMP; D009218:Myosins; D007741:Labetalol