[Cytoplasmic thyroxine-binding protein: the role of RNA in the interactions between thyroxine receptor and cell nuclei].
The presence of 3H-orotic acid in the cytoplasmic receptor fraction isolated in our laboratory, the sensitivity of this fraction to treatment with RNAases accompanied by a shift of the absorption peak of the receptor preparation towards the long-wave region as well as the use of the absorption filter technique point to the existence of ternary thyroxine-thyroxine-binding protein-RNA complex in the cytoplasm. It was found that the cytoplasmic hormone-receptor complex of thyroxine is a genetically active form which can interact with the nuclei and modify the activity of chromatin. The role of RNA in these interactions is discussed.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002850:Chromatography, Gel; D003600:Cytosol / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011988:Receptors, Thyroid Hormone / Q000302:isolation & purification / Q000378:metabolism*; D012260:Ribonucleases; D013056:Spectrophotometry, Ultraviolet; D013975:Thyroxine-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*
D011988:Receptors, Thyroid Hormone; D013975:Thyroxine-Binding Proteins; D012313:RNA; D012260:Ribonucleases
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