An antiestrogenic action of interferons in human breast cancer cells.
The antiproliferative and antiestrogenic effects of human interferon on estrogen-dependent CG-5 human breast cancer cells in vitro are reported. Fibroblast beta - interferon as well as recombinant alpha - and gamma -interferon inhibited proliferation of CG-5 cells in a dose and time - dependent fashion. In addition, they completely suppressed the two-fold increase in cell number induced by estradiol and showed an additive antiproliferative effect when used in combination with the antiestrogen tamoxifen. These antiestrogenic effects of interferons were accompanied by a reduced receptor binding of estradiol to the cells.
D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D011994:Recombinant Proteins; D013629:Tamoxifen / Q000494:pharmacology; D013997:Time Factors
D004967:Estrogens; D007370:Interferon Type I; D011994:Recombinant Proteins; D013629:Tamoxifen; D007371:Interferon-gamma; D007372:Interferons