Influence of route of administration on potency of the selective 5HT-1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, in rats.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) decreased the concentration of 5-hydroxyindoleacetic acid (5HIAA), the deaminated metabolite of serotonin, in rat brain. 8-OH-DPAT was much more potent when injected subcutaneously than when injected intraperitoneally, the potency difference being approximately 17-fold. The important influence of route of administration on the potency of 8-OH-DPAT must be considered in interpreting the various functional effects that have been reported with it.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000494:pharmacology*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D006897:Hydroxyindoleacetic Acid; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin