[Long-term analysis of non-A, non-B hepatitis--clinical, histologic and immunologic findings].
By means of a long-term analysis of histological and clinical-biochemical data taken of a group of patients (n = 38) having contracted an acute viral hepatitis non-A, non-B with a uniform parenteral source of infection evidence is given concerning the dynamic processes in the course of chronic non-A, non-B hepatitis. The analysis was therefore not based on the total biopsy material but on a section of 143 liver biopsies of patients who had been punctured at least 3 times (up to 6 times) in the 7 years of examination. A rate of 57,2% chronic persistent and 42,8% chronic lobular hepatitis was ascertained. A chronic active hepatitis or liver cirrhosis were not found. Both the histological activity degrees and ALAT-mean values were declining during the follow-up study though attacks (ALAT) and histological reactivations were observed in the 7th year, too. The data suggest that the chronic liver changes that developed in this type of non-A, non-B hepatitis proved to be extremely lingering but as a whole a regressive tendency could be observed.
D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000276:immunology / Q000473:pathology*; D006521:Hepatitis, Chronic / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D005719:gamma-Globulins / Q000378:metabolism
D007136:Immunoglobulins; D005719:gamma-Globulins; D000410:Alanine Transaminase
Langzeitanalyse der Virushepatitis NonA-NonB--klinische, histologische und immunologische Befunde.