Griffonia simplicifolia I-A4 staining of mice glomerular tufts and its alteration in diabetic mice.
An isolectin from Griffonia simplicifolia (GS) seed--GSI-A4--stained the outer aspect of glomerular tuft (GT) intensely in the kidneys of ICR, C57BL/6J, BALB/c and NSY mice. Loss of the GSI-A4 staining was observed in the sclerotic areas of glomeruli in diabetic mice (NSY mice). This interesting staining will be useful for the analysis of the constitutions of GT in various experimental models of renal glomerular diseases in mice.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D037121:Plant Lectins; D013194:Staining and Labeling
D006023:Glycoproteins; C045475:Griffonia simplicifolia lectins; D037102:Lectins; D037121:Plant Lectins