[Clinical experiences with systemic high-dosage short-term fibrinolysis in acute myocardial infarct].
In 50 patients with acute myocardial infarction the systemic highly dosed short-term lysis with streptokinase took place within the 6-hour limit. 27 patients showed a normalisation of the ST-distance still during the treatment, 16 of whom did not develop any signs of necrosis in the ECG also in the further course. Pre-existing disturbances of rhythm receded under the infusion of streptokinase in 8 of 9 patients. In 11 patients arrhythmias appeared under the lysis, which could be brought under control in intensive-medical conditions. 4 patients died, 1 patient suffered a re-infarction. The results of the treatment were better, when the fibrinolysis began within 3 hours after the acute onset. Severe side effects did not appear.
D000328:Adult; D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D012008:Recurrence; D013300:Streptokinase / Q000009:adverse effects / Q000627:therapeutic use*; D013918:Thrombin Time
D005340:Fibrinogen; D013300:Streptokinase
Klinische Erfahrungen mit der systemischen hochdosierten Kurzzeitfibrinolyse beim akuten Myokardinfarkt.