Reactivity of IgM-rheumatoid factors of human, feline and bovine sera.
The reactions of IgM-rheumatoid factors (IgM-RFs) from human, feline and bovine sera were examined with their homologous monomeric IgGs and with IgGs of other species. Cross-reactivities with IgGs of other species were observed in each separate system. By the use of an enzyme-linked immunosorbent assay (ELISA), measurable differences in reactivities were obtained. The results suggest that IgM--RFs of human and feline origin recognize a similar determinant on the Fc region of IgG. A different moiety on the latter molecule appears to be involved in the reactivity of bovine IgM-RF.
D000818:Animals; D000915:Antibody Affinity; D002415:Cats; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*; D013045:Species Specificity
D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor