The prostaglandin response in guinea-pig taenia caeci and trachea smooth muscle of different ages.
The concentration-response curves for the carbachol-induced contraction of smooth muscle cells of guinea-pig taenia caeci and trachea were not dependent on tissue age. The prostaglandin E2 and F2 alpha responses increased with age in taenia caeci in contrast with the PGE2 response evoked in trachea. The high-potassium responses evoked in taenia caeci and trachea both increased at higher tissue age. Methoxyverapamil only inhibited the age-dependent responses. The results suggest that it is mainly the voltage-dependent calcium channels that are involved in the age-dependent prostaglandin response.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002432:Cecum / Q000187:drug effects / Q000378:metabolism; D015237:Dinoprost; D015232:Dinoprostone; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D014132:Trachea / Q000187:drug effects / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology
D007473:Ion Channels; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D002217:Carbachol; D015237:Dinoprost; D014700:Verapamil; D015232:Dinoprostone