n-Butyrate increases c-erb A oncogene expression in human colon fibroblasts.
We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a beta-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.
D000199:Actins / Q000235:genetics; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D003106:Colon / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012313:RNA / Q000235:genetics
D000199:Actins; D002087:Butyrates; D020148:Butyric Acid; D012313:RNA; D004247:DNA