A case of midgut carcinoid with breast metastasis and cellular localization of serotonin and substance P.
A case of midgut carcinoid with breast metastasis is reported. Hepatic metastases stored large amounts of serotonin as demonstrated by the Falck-Hillarp technique. Immunocytochemically serotonin and substance P, which may co-exist in gut enterochromaffin cells, were demonstrated in separate populations of tumor cells both in the hepatic and mammary neoplasms.
D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000032:analysis / Q000556:secondary*; D002276:Carcinoid Tumor / Q000032:analysis / Q000473:pathology / Q000556:secondary; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000032:analysis; D008303:Malignant Carcinoid Syndrome / Q000378:metabolism*; D012701:Serotonin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
D012701:Serotonin; D013373:Substance P