A review of mechanism of action of aspirin and its potential as an immunomodulating agent.
The basic aspects of PG immune function interactions are presented and discussed herein. Specifically, the findings of many of the studies summarized suggest the possibility that pharmacologic actions of aspirin may play a role in enhancing the immune response to viral infections. Mechanisms proposed for ASA include: PG inhibition via the cyclooxygenase pathway, an interaction with cyclic nucleotides, altered cellular interactions with PG's, altered leukocyte migration, activation of complement components, stimulation of monocytopoiesis, and induction of interferon. Since dual effects for ASA have been observed for several of these mechanisms, it is clear that its role in modulating the immune response to viral infections is very complex. This delineation of a role for ASA, that would seem to constitute a defense against viral infections leads to an area worthy of study and surveillance.
D001241:Aspirin / Q000494:pharmacology*; D001327:Autoimmune Diseases / Q000188:drug therapy; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007372:Interferons / Q000502:physiology; D008084:Lipoxygenase / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D014777:Virus Diseases / Q000188:drug therapy*
D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D007372:Interferons; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin