[Effect of preparations from the vitreous body having anti-angiogenic properties on the metastatic spread of Lewis lung carcinoma].
Preparations extracted from the vitreous body were studied for their effect on the activity of angiogenesis and metastatic spreading. A semipurified extract and a protein preparation with molecular weight 12,000 exerted an inhibitory effect on metastasis growth of Lewis carcinoma after removal of the primary tumour. Application of these preparations has also led to an inhibition of the capillary network growth which developed subcutaneously in the site of the organic glass plate implanting, which was considered as an inhibition of the angiogenesis activity. Such an effect was not observed with the use of hyaluronate, extracted from the vitreous body.
D020533:Angiogenesis Inhibitors; D000818:Animals; D002417:Cattle; D008175:Lung Neoplasms / Q000098:blood supply / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology; D014822:Vitreous Body / Q000032:analysis*
D020533:Angiogenesis Inhibitors; D011506:Proteins; D014020:Tissue Extracts
Vliianie preparatov iz steklovidnogo tela glaz, obladaiushchikh antiangiogennym svoĭstvom, na metastazirovanie kartsinomy legkikh L'iuis.