title: [Comparative study of the surface-active properties of gramicidin S and its derivatives by polarography].
abstract: Gramicidin S and its derivatives by the free amino groups of the ornithine moieties were studied with respect to their effect on interface tension of mercury and the polarographic background for comparative estimation of the surface active properties of these compounds. The same way as the compounds preserving their main properties, the neutral and acid derivatives lowered the polarographic maximum. No correlation between the level of the antimicrobial and membrane activity and the surface active properties of the tested compounds was observed. It is likely that the direct cause of the induced biological effect is not connected with the surface active properties responsible for possible interaction of the tested substances with the cell (protoplast).
mesh_terms: D002463:Cell Membrane Permeability / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006096:Gramicidin / Q000494:pharmacology*; D008837:Micrococcus / Q000187:drug effects; D011048:Polarography / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents
chemical_list: D013501:Surface-Active Agents; D006096:Gramicidin
vernacular_title: Sravnitel'noe izuchenie poverkhnostno-aktivnykh svoĭstv gramitsidina S i ego proizvodnykh poliarograficheskim metodom.