[Bronchial cancers with morphologic and immunohistochemically diversely differentiated metastases].
We report on two unusual adenocarcinomas of the lung. The primary of the first case could be classified as a "solid adenocarcinoma" of the lung, whereas the metastases were undifferentiated and contained syncytiotrophoblast-like tumor cells. The primary of the second case consisted of diversely differentiated cells including adenocarcinomatous and syncytiotrophoblast-like cells, while the metastases were either adenocarcinomatous or syncytiotrophoblastic-like differentiated. Immunohistochemically, both primaries showed abundant CEA and little beta-HCG, while the metastases exhibited little CEA and abundant beta-HCG. The implications of such differences between the primaries and their metastases for tumor-cell heterogeneity and tumor classification are discussed.
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010446:Peptide Fragments / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments
Uber Bronchialkarzinome mit morphologisch und immunhistochemisch abweichend differenzierten Metastasen.