[Activity of lysosomal proteolytic enzymes in rat gastric mucosa during contrical administration].
Contrical was shown to decrease distinctly the activity of cathepsins A, B, C and D in rat gastric mucosa in situ and in vitro. At the same time, application of contrical as a polymeric complex with glue MK-8 resulted in penetration of the drug into the incubation mixture and led to inhibition of lysosomal proteinases. The data obtained suggest that simultaneous use of contrical and glue MK-8 may serve as an adequate therapeutic approach in local treatment of gastroduodenal ulcers.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D011480:Protease Inhibitors; D007611:Aprotinin
Aktivnost' proteoliticheskikh fermentov lizosom v slizistoĭ obolochke zheludka krys pri deĭstvii kontrikala.