title: Effect of Datura (seed) on rat brain and urinary metabolites.
abstract: The effect of Datura alba (seed) extract on the brain and urinary metabolites of rats was studied. Treatment with Datura brought about a decrease in the activity of brain lipid peroxidase and catalase while an increase in the activity of fructose diphosphate aldolase and glucose 6-phosphate dehydrogenase was observed. An increase in the DNA and RNA contents of brain was noted after the treatment with Datura. The study also showed a marked decrease in the excretion of 5-hydroxyindole acetic acid and vanillyl mandelic acid in the urine of rats given Datura extract.
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D013286:Datura stramonium; D004734:Energy Metabolism / Q000187:drug effects; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012313:RNA / Q000378:metabolism; D051381:Rats; D014642:Vanilmandelic Acid / Q000652:urine
chemical_list: D010936:Plant Extracts; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D012313:RNA; D004247:DNA; D010088:Oxidoreductases; D005634:Fructose-Bisphosphate Aldolase