Production of lymphokines by murine cortisone resistant thymocytes stimulated by concanavalin A. III. Effect of cytotoxic pretreatment with anti-Lyt antibodies on interleukin-2 and interferon producing cells.
Lyt phenotypes of interleukin-2 and interferon producing Balb/c cortisone resistant thymocytes, stimulated by concanavalin A in vitro, were studied using cytotoxic anti-Lyt-1.2 and anti-Lyt-2.2 alloantisera and monoclonal antibodies. It was found that while interleukin-2 was produced by both Lyt1+ and Lyt2+ cells, the ability to secrete IFN was limited to Lyt2+ cells only.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003348:Cortisone / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000961:Antilymphocyte Serum; D007376:Interleukin-2; D003208:Concanavalin A; D007372:Interferons; D003348:Cortisone