Resuscitation in haemorrhagic shock--pulmonary and renal effects: an adverse effect of stabilised plasma protein solution on renal function?
In a model of severe canine haemorrhagic shock, greyhound dogs were randomly allocated to resuscitation with 0.9% saline, polygelin, hetastarch, or stabilised plasma protein solution (SPPS). Resuscitation was continued back to baseline pulmonary artery wedge pressure, and extravascular lung water (EVLW) and urine output were measured. EVLW following resuscitation was higher in the saline group than in any of the three colloid groups. Urine output following resuscitation was significantly lower in the SPPS group than in any other group. The results suggest that SPPS has an adverse effect on renal function in this model.
D000818:Animals; D001798:Blood Proteins / Q000633:toxicity*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005110:Extracellular Space / Q000378:metabolism; D005440:Fluid Therapy / Q000009:adverse effects*; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology; D007668:Kidney / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000187:drug effects; D011097:Polygeline / Q000494:pharmacology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012151:Resuscitation / Q000009:adverse effects*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
D001798:Blood Proteins; D006895:Hydroxyethyl Starch Derivatives; D011097:Polygeline