Substance P antagonists in substantia nigra are anticonvulsant.
Bilateral intranigral microinfusion of antagonist analogs of substance P significantly attenuated convulsions induced by maximal electroshock or intravenous bicuculline in rats. Infusions of substance P antagonists placed adjacent to the substantia nigra in the vicinity of the lateral hypothalamus were without anticonvulsant action. Our data indicate an as yet undescribed role for substance P antagonists in the regulation of seizure susceptibility, and provide additional evidence that decreasing the activity of substantia nigra outputs is anticonvulsant.
D000818:Animals; D001640:Bicuculline; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology
D013373:Substance P; D001640:Bicuculline