Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse.
Behavioural responses to tachykinins were observed following intracisternal administration in mice. The synthetic NK-3 agonists senktide and L-363,851 caused behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying. Neurokinin B produced some features of the serotonin (5-HT) syndrome, while substance P, neurokinin A and eledoisin failed to elicit any such behaviours. Senktide-induced head twitches were prevented by pretreatment with the 5-HT2 antagonists ketanserin and ritanserin, while forepaw treading was attenuated by the 5-HT1 antagonists (-)-pindolol and methysergide. These data suggest that NK-3 agonists interact with central 5-HT mechanisms.
D000818:Animals; D004600:Eledoisin / Q000494:pharmacology; D005260:Female; D051379:Mice; D015287:Neurokinin B; D009479:Neuropeptides / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D018039:Receptors, Tachykinin; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology
D009479:Neuropeptides; D009842:Oligopeptides; D010446:Peptide Fragments; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D012702:Serotonin Antagonists; C057852:substance P (5-11), Asp(5,6)-MePhe(8)-; C054347:L 363851; D012701:Serotonin; D013373:Substance P; D004600:Eledoisin; D015287:Neurokinin B