Paroxysmal neuronal depolarizations in the rat motorcortex in vivo: intracellular injection of the calcium agonist BAY K 8644.
Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and after depolarization of paroxysmal neuronal depolarizations.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D007473:Ion Channels / Q000502:physiology*; D009044:Motor Cortex / Q000503:physiopathology*; D010406:Penicillins; D051381:Rats
D007473:Ion Channels; D010406:Penicillins; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D002118:Calcium