title: Nodal gliomatosis and alpha-fetoprotein production. Two unusual facets of grade I ovarian teratoma.
abstract: We describe the case of a 10-month-old infant who had a grade I solid teratoma of the ovary. It is remarkable that the tumor was accompanied by nodal gliomatosis and elevated serum alpha-fetoprotein (AFP) level. To our knowledge, this is the first description of nodal gliomatosis in the absence of gliomatosis peritonei, and the fifth report of elevated serum AFP with a pure teratoma. Like gliomatosis peritonei, nodal gliomatosis appears to be a benign condition, requiring no adjuvant therapy. The nature of the nodal implants was confirmed by positive immunoreactivity for glial fibrillary acidic protein. By a similar method, AFP was found in the primary tumor in cells lining yolk-sac-like vesicles and intestinal-type glands.
mesh_terms: D002828:Choristoma / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D009378:Neoplasms, Multiple Primary; D009457:Neuroglia; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013724:Teratoma / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D000509:alpha-Fetoproteins