[Gastrin, gamma-endorphin and somatostatin cells of the stomach and duodenum in patients with duodenal ulcer treated with dalargin].
The distribution of gastrin-, gamma-endorphin and somatostatin-producing cells in antral and duodenal mucosa was studied in biopsies from 26 patients with duodenal ulcer and from 13 controls by the immunohistochemical (PAP) method. The number of antral somatostatin-producing cells after dalargin treatment was significantly higher in comparison with controls and patients treated with antacids plus atropine. These changes may be connected with the antiulcer activity of dalargin, a new opioid peptide drug.
D000328:Adult; D002838:Chromaffin System / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000473:pathology*; D004386:Duodenum / Q000473:pathology; D004723:Endorphins / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004759:Enterochromaffin Cells / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D011706:Pyloric Antrum / Q000473:pathology; D013004:Somatostatin / Q000378:metabolism; D018823:gamma-Endorphin
D004723:Endorphins; D005755:Gastrins; D005768:Gastrointestinal Hormones; D013004:Somatostatin; D004743:Enkephalin, Leucine; D018823:gamma-Endorphin; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Gastrinovye, gamma-éndorfinovye i somatostatinovye kletki zheludka i dvenadtsatiperstnoĭ kishki u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki pri lechenii dalarginom.