The effect of verapamil and the calcium ionophore A 23187 on the calcium and phosphorus content of bone.
Verapamil was administered 30 days to adult male rats in a dose of 2 mg/rat per day and the calcium ionophore A 23187 to another group in a dose of 10 micrograms/rat per day. After verapamil, the bone calcium and phosphorus concentration rose significantly compared with the control group, whereas after ionophore A 23187 the bone calcium concentration fell statistically significantly.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D014700:Verapamil / Q000494:pharmacology*
D007473:Ion Channels; D008903:Minerals; D010758:Phosphorus; D000001:Calcimycin; D014700:Verapamil; D002118:Calcium