A new model for quantification of microvascular regeneration after a lesion of the rat cerebral cortex.
The purpose of this study is to validate a method for the quantification of the neovascularization in the vicinity of a lesion made in the cerebral rat cortex. A cavity, made by aspiration in the occipital cortex of young rats, induces around the lesion a parenchymal and vascular reaction. The parenchymal reaction is characterized by cellular necrosis and gliosis. The vascularization is more dense around the cavity than in normal cortex. Morphometric analysis indicates, 8 days after the lesion, a 130% increase of the total length of the vessels in comparison to the contralateral normal cortex.
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000293:injuries*; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D051381:Rats; D011919:Rats, Inbred Strains