Effect of aging on the rate of axonal transport of choline-phosphoglycerides.
The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport rate was determined by plotting the distance covered by the front of transported radioactivity as a function of the time employed. In aged animals the rate of the choline-phosphoglyceride anterograde axonal transport was about 68% lower than that of adults; furthermore, the rate slowed down along the nerve in the proximal-distal direction. This altered axonal transport mechanism might contribute to the degenerative processes observed in distal regions of peripheral nerve fibers of aged animals.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001370:Axonal Transport; D005990:Glycerol / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009046:Motor Neurons / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000254:growth & development / Q000378:metabolism
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D005990:Glycerol