Crystal structure of a 1,4-dihydropyridine with enantiomers showing opposite effects on calcium channels: structural features of calcium channel agonists and antagonists.
The structure of the calcium channel modulator isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-nitro- 3-pyridinecarboxylate has been determined by X-ray analysis. Structural and stereochemical features are discussed in relation to previously determined structures of calcium agonists and antagonists of the 1,4-dihydropyridine type, and in relation to a newly proposed model for the dihydropyridine binding site.
D002121:Calcium Channel Blockers / Q000032:analysis*; D003460:Crystallization; D004095:Dihydropyridines / Q000032:analysis*; D007473:Ion Channels / Q000187:drug effects*; D008968:Molecular Conformation; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D007473:Ion Channels; C038806:1,4-dihydropyridine