Bacteria and their products peptidoglycan and teichoic acid potentiate antigen-induced histamine release in allergic patients.
Histamine release was examined in leukocyte suspensions from patients allergic to grass pollen, mite or cat dander or to bacteria (antigen). When the cells were challenged with specific antigen plus bacteria to which the person was not sensitized, these bacteria were found to potentiate the allergic histamine release. The potentiating effect by bacteria might be due to the bacterial cell wall components, peptidoglycan and teichoic acid, which mimic the effect of bacteria.
D000942:Antigens, Bacterial / Q000276:immunology*; D001249:Asthma / Q000503:physiopathology; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D010457:Peptidoglycan; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D013682:Teichoic Acids
D000942:Antigens, Bacterial; D010457:Peptidoglycan; D013682:Teichoic Acids