31-P-NMR-spectroscopy on ischemic and reperfused rat hearts: effects of iloprost.
Effects of iloprost on the behaviour of high energy phosphate contents were investigated in global ischemic and reperfused rat hearts prepared according to Langendorff. Iloprost application before and after 20 min of ischemia at a dosage of 9-12 pg/g heart weight x min improved the availability of high energy phosphates as was shown by CP/Pi ratio during the first hour of reperfusion.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D011464:Epoprostenol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D016285:Iloprost; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010710:Phosphates; D010725:Phosphocreatine; D011464:Epoprostenol; D016285:Iloprost