title: [Significance of clinical and laboratory chemical parameters for the course and prognosis of non-Hodgkin's lymphomas].
abstract: Using a regression model, the prognostic significance of clinical and biochemical parameters as well as of histology was analyzed in a group of 336 patients with Non-Hodgkin's lymphoma. A stochastic process model was used for evaluation of the course of disease. With respect to overall survival, serum-LDH-activity, performance status, and the histologically defined grade of malignancy were found to be the most important prognostic parameters, as well as age, though that to a lesser extent. In the course of disease, stage was the most relevant factor for achievement of a complete remission. In patients without remission, survival was determined mainly by histology and serum-LDH-activity; the latter was also of importance for duration of remission. Our study shows that histology is not the only prognostic factor in NHL but that other parameters, mainly serum-LDH-activity and performance status, also have to be considered in comparing different groups of patients.
mesh_terms: D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood; D000510:Alpha-Globulins / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D001799:Blood Sedimentation; D006452:Hemoglobinometry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008223:Lymphoma / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D009367:Neoplasm Staging; D010976:Platelet Count; D011379:Prognosis; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000510:Alpha-Globulins; D012709:Serum Albumin; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase
vernacular_title: Bedeutung klinischer und laborchemischer Parameter für Verlauf und Prognose der Non-Hodgkin-Lymphome.