Pulmonary clearance of inhaled 99mTc-DTPA: effect of the detergent dioctyl sodium sulfosuccinate in aerosol.
The influence of the detergent dioctyl sodium sulfosuccinate on clearance from the lungs of inhaled technetium-99m-labelled dietylenetriamine pentaacetate (99mTc-DTPA) was studied in twelve rabbits. An aerosol of dioctyl sodium sulfosuccinate or its vehicle alone was administered for 5 min prior to aerosolized 99mTc-DTPA via a bag-in-bottle system. Time-activity curves were obtained from the right lung with a gamma camera. In rabbits given detergent, clearance of 99mTc-DTPA was significantly faster than in rabbits given vehicle alone. No changes were seen in arterial PO2 and compliance. Our data indicates that the transfer of 99mTc-DTPA from alveoli to blood can be accelerated by administration of the detergent dioctyl sodium sulfosuccinate without any dramatic change in surface tension. Clearance of 99mTc-DTPA may be a very sensitive indicator of altered surfactant function.
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D002199:Capillary Permeability; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology; D008168:Lung / Q000378:metabolism*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011817:Rabbits; D013667:Technetium / Q000493:pharmacokinetics*; D016284:Technetium Tc 99m Pentetate
D000336:Aerosols; D009942:Organometallic Compounds; D004143:Dioctyl Sulfosuccinic Acid; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate