title: The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. I. In vivo studies.
abstract: The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos (Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a period of 2, 4 or 6 weeks. The activities of cholinesterase (ChE), beta-glucuronidase (beta-glu), lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE)-in brain homogenates, and the activities of lipase and amylase-in homogenates of the pancreas. Cholinesterases were inhibited in the course of both acute and chronic poisoning with Polfos. During the acute poisoning a sharp increase in the activity of beta-glu in the blood serum, 1 and 2 h after the pesticide administration, was observed. Polfos inhibited lipase and amylase both after acute and chronic treatment.
mesh_terms: D000681:Amylases / Q000097:blood / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000633:toxicity*; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism; D004798:Enzymes / Q000097:blood*; D005260:Female; D005966:Glucuronidase / Q000097:blood / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008049:Lipase / Q000097:blood / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004798:Enzymes; D007306:Insecticides; C006037:methylbromfenvinphos; D008049:Lipase; D002802:Cholinesterases; D000681:Amylases; D005966:Glucuronidase; D002709:Chlorfenvinphos