[Iron-sulfur respiratory chain centers, ribonucleotide reductase activity and biosynthesis of macromolecules in the spleen of mice during acute radiation injury].
The functional status of iron-sulphur centers (ISC) of mitochondrial electron transport chain, ribonucleotide reductase (RR) activity and macromolecule biosynthesis in mouse spleen were studied during acute radiation sickness induced by whole-body gamma-irradiation of mice with a dose of 6 Gy. The ESR signal of active RR was registered in the spleen; the RR activity dynamics during acute radiation sickness was described. The RR activity was inhibited at early post-irradiation times (from 30 min to 12 h). Drastic inhibition of DNA biosynthesis and stimulation of transcription were registered. The increase in the RR activity and ISC content, which occurred 1-3 days following irradiation, was associated with the increase in the rate of protein biosynthesis.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D008297:Male; D008667:Metalloproteins / Q000378:metabolism*; D051379:Mice; D012313:RNA / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D012264:Ribonucleotide Reductases / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism* / Q000528:radiation effects
D007506:Iron-Sulfur Proteins; D008667:Metalloproteins; D012313:RNA; D004247:DNA; D012264:Ribonucleotide Reductases
Zhelezosernye tsentry dykhatel'noĭ tsepi, ribonukleotidreduktaznaia aktivnost' i biosintez makromolekul v selezenke mysheĭ pri ostroĭ luchevom porazhenii.