On the neurolinguistic nature of language abnormalities in Huntington's disease.
Spontaneous language of 18 patients suffering from Huntington's disease and 15 dysarthric controls suffering from Friedreich's ataxia were investigated. In addition, language functions in various modalities were assessed with the Aachen Aphasia Test (AAT). The Huntington patients exhibited deficits in the syntactical complexity of spontaneous speech and in the Token Test, confrontation naming, and language comprehension subtests of the AAT, which are interpreted as resulting from their dementia. Errors affecting word access mechanisms and production of syntactical structures as such were not encountered.
D000328:Adult; D000849:Anomia / Q000503:physiopathology; D001037:Aphasia / Q000503:physiopathology*; D001184:Articulation Disorders / Q000503:physiopathology; D001479:Basal Ganglia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D009483:Neuropsychological Tests; D010700:Phonetics; D012660:Semantics; D013068:Speech Production Measurement