Basophil histamine release. A study in allergy to suxamethonium.
A patient who suffered a severe hypotensive episode after induction of anaesthesia, was subsequently found to show positive skin-test responses to suxamethonium. Investigation revealed that suxamethonium induced basophils from the patient to release histamine to an extent comparable to that found after exposure to anit-IgE. Basophils from control subjects showed no such response. Basophil histamine release may offer a useful approach to the investigation of adverse drug reactions.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001491:Basophils / Q000187:drug effects*; D004342:Drug Hypersensitivity / Q000097:blood*; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D007073:Immunoglobulin E / Q000276:immunology; D013390:Succinylcholine / Q000009:adverse effects*
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E; D013390:Succinylcholine