N,N-diethylaminoalkoxy-4,7-phenanthrolines and 1,8-diazaflourene derivatives, a novel class of potential interferon inducers and antiviral agents: interactions with nucleic acids in vitro and cellular activities.
Tilorone aza-analogues, derivatives of 4,7-phenanthroline and 1,8-diazafluorene, were examined as DNA-complexing agents by spectral and electrophoretic methods. The binding process includes at least two types of interactions: electrostatic and, possibly, intercalation. Complex formation with the denatured DNA was also observed, but its nature remained unsolved. Binding and thermodynamic parameters were determined. All ligands studied showed weak antiviral activity and essentially no interferon induction when assayed in vitro and in vivo. It was concluded that interferon induction by tilorone may involve specific cell receptors or intermediaries.
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism* / Q000494:pharmacology; D002412:Cations / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D004269:DNA, Bacterial / Q000378:metabolism; D005449:Fluorenes / Q000378:metabolism*; D007369:Interferon Inducers / Q000378:metabolism* / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis; D007739:L Cells / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009691:Nucleic Acid Denaturation; D013329:Structure-Activity Relationship; D013994:Tilorone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D002412:Cations; D004269:DNA, Bacterial; D005449:Fluorenes; D007369:Interferon Inducers; D004247:DNA; D007372:Interferons; D013994:Tilorone