UV sensitivity of human keratinocyte and Langerhans cell-expressed HLA-DR antigens: a comparison.
HLA-DR expression on human keratinocytes (KC) was induced in vivo by intradermal injection of purified protein derivative of tuberculin (PPD). Neither preceding nor subsequent exposure of the PPD injection site to a dose of approximately 2 MED of UVB radiation abolished KC HLA-DR, though subsequent irradiation caused a slight diminution in the intensity of the antigen expression. By contrast, epidermal Langerhans cell (LC) HLA-DR and T6 expressions in normal epidermis were greatly reduced by an identical dose of UVB. Pemphigus antigen on the surface of KC was not affected by irradiation or PPD injection.
D000328:Adult; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology / Q000528:radiation effects*; D005260:Female; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens / Q000528:radiation effects*; D006684:HLA-DR Antigens / Q000528:radiation effects*; D006801:Humans; D007633:Keratins / Q000528:radiation effects*; D007801:Langerhans Cells / Q000276:immunology / Q000528:radiation effects*; D008297:Male; D010392:Pemphigus / Q000276:immunology; D014466:Ultraviolet Rays
D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D007633:Keratins