Nuclear matrix association regions of rat alpha 2-macroglobulin gene.
We have identified DNA fragments which bind specifically to the nuclear matrix in vitro, termed matrix association regions (MARs), in the first and fourth introns of rat alpha 2-macroglobulin gene. The MAR in the first intron is enriched with sequences closely related to the cleavage consensus of topoisomerase II, and contains the binding site of nuclear factor-alpha, a sequence-specific DNA binding protein reported previously.
D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000032:analysis*; D004264:DNA Topoisomerases, Type I / Q000235:genetics; D005786:Gene Expression Regulation; D007438:Introns; D011401:Promoter Regions, Genetic; D051381:Rats; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins; D004264:DNA Topoisomerases, Type I