Interaction of myelin basic protein with the different components of the ATP,Mg-dependent protein phosphatase system.
Myelin basic protein (MBP) reduces the amount of phosphatase activity produced in the kinase FA-mediated activation of the ATP,Mg-dependent phosphatase. MBP was shown not only to inhibit the activated enzyme, but also to impair the kinase FA-mediated activation of the inactive phosphatase. In addition MBP prevents the time-dependent inactivation of the catalytic subunit by the modulator protein. These observations point to a regulatory role for MBP in the reversible activation of the ATP,Mg-dependent protein phosphatase by kinase FA.
D002384:Catalysis; D004789:Enzyme Activation / Q000187:drug effects; D004676:Myelin Basic Protein / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*
D004676:Myelin Basic Protein; D010749:Phosphoprotein Phosphatases