[Microscopic changes in the human liver after intra-arterial infusion of anticancer agents suspended in lipiodol].
Microscopic injury to the human liver after an intraarterial infusion of anti-cancer agents suspended in lipiodol has been evidenced by Hematoxylin-Eosin staining and by Oil Red O staining. In cases involving primary hepatic tumors, the liver tumor tissue has been injured severely while normal tissue showed no injury. In cases involving metastatic liver tumors, the tumor tissue, and also the normal liver tissue was injured though the latter injury was only mild. However, when multi-anticancer agents that were suspended in lipiodol were infused intra-arterially, the normal liver tissue was injured, even from a single drug suspension.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D013274:Stomach Neoplasms
D000970:Antineoplastic Agents; D007459:Iodized Oil