Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms.
Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activate forebrain dopaminergic systems in part by separate mechanisms.
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004597:Electroshock; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013373:Substance P / Q000378:metabolism
D011954:Receptors, Dopamine; D013373:Substance P; D010622:Phencyclidine; D004298:Dopamine; D006719:Homovanillic Acid