Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo.
D000262:Adenylyl Cyclases / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects*; D004351:Drug Resistance; D004789:Enzyme Activation; D011464:Epoprostenol / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D016285:Iloprost; D007700:Kinetics; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000378:metabolism; D014652:Vascular Diseases / Q000188:drug therapy
D011457:Prostaglandins D; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D011464:Epoprostenol; D000262:Adenylyl Cyclases; D016285:Iloprost; D015230:Prostaglandin D2