[Stimulation of nucleic acid biosynthesis by phosphopentoses].
Phosphopentose stimulation of nucleic acids biosynthesis for 3h after subcutaneous phosphopentose administration in doses of 18 and 27 mg per rat has been stated. Injections of phosphopentoses (ribose-5-phosphate, xylulose-6-phosphate, ribulose-5-phosphate in the ratio of 1.0:0.3:0.3) were followed by a two-fold increase in the rate of [2-14C] orothic acid incorporation into cytoplasmic RNA of the rat liver. It is supposed that rapidly exchanging types of RNA contribute most of all to the effect of the label incorporation increase and the stimulation mechanism is associated with a rise of phosphoribosyl pyrophosphate accessibility as a substrate and an allosteric regulator of key enzymes of the synthesis of purine and pyrimidine nucleotides.
D000818:Animals; D002850:Chromatography, Gel; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009963:Orotic Acid / Q000378:metabolism; D010428:Pentosephosphates / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013268:Stimulation, Chemical
D010428:Pentosephosphates; D009963:Orotic Acid; D012313:RNA
Stimuliatsiia biosinteza nukleinovykh kislot fosfopentozami.