title: [Acute and chronic toxicity of psychotropic drugs].
abstract: Within psychotropic drugs acute toxicity is highest in antidepressants (thymoleptics, MAO-inhibitors, lithium), lower in neuroleptics, and very low in anxiolytics. The order of decreasing chronic toxicity is: neuroleptics, antidepressants, anxiolytics. Each class of psychotropic drugs has a specific toxicological problem. With anxiolytics the major problems stem from their misuse and overuse. With neuroleptics tardive dyskinesia is a serious threat to longterm therapy. Finally, antidepressants are characterized by a low therapeutic index and a resulting high incidence of severe and fatal poisoning cases, both intentional and accidental.
mesh_terms: D014151:Anti-Anxiety Agents / Q000506:poisoning; D000928:Antidepressive Agents / Q000506:poisoning; D014150:Antipsychotic Agents / Q000506:poisoning; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000506:poisoning* / Q000627:therapeutic use; D013405:Suicide
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D011619:Psychotropic Drugs
vernacular_title: Akute und chronische Toxizität von Psychopharmaka.