Comparative effects of alpha, beta and gamma human interferons on a HBsAg-producing human hepatoma cell line.
The effects of all the three types of human interferons (alpha, beta and gamma) on a human hepatoma cell line with hepatitis B virus (HBV)-DNA sequences integrated into the host DNA and producing hepatitis B surface antigen (HBsAg) in culture medium were assayed. The aim of the present research was to test human interferon preparations in an in vitro system for hepatitis B virus, and to compare the observed effects. The results evidenced both the antireplicative activity principally showed by preparations of beta and gamma human interferons and the inhibition of HBsAg production by high concentrations of gamma human interferon.
D006528:Carcinoma, Hepatocellular; D002452:Cell Count; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008113:Liver Neoplasms
D006514:Hepatitis B Surface Antigens; D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons