Levels of neurokinin A, neurokinin B and substance P in rabbit iris sphincter muscle.
We investigated the contents of neurokinin A, neurokinin B and substance P in the rabbit iris sphincter muscle, combining HPLC and radioimmunoassay, as our previous reports indicated that a slow component of neurogenic contractions of this muscle is most probably mediated by such tachykinins. The concentrations of these tachykinins were 44.3 +/- 8.7 fmol/mg protein, 35.3 +/- 10.2 fmol/mg protein and 186.8 +/- 29.8 fmol/mg protein (N = 4), respectively. These results demonstrated that neurokinin A, neurokinin B and substance P are all present in the rabbit iris sphincter muscle.
D000818:Animals; D005260:Female; D007498:Iris / Q000032:analysis*; D008297:Male; D009130:Muscle, Smooth / Q000032:analysis*; D015288:Neurokinin A; D015287:Neurokinin B; D009479:Neuropeptides / Q000032:analysis* / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D011817:Rabbits; D013373:Substance P / Q000032:analysis*; D015320:Tachykinins
D009479:Neuropeptides; D011498:Protein Precursors; D012333:RNA, Messenger; D015320:Tachykinins; C044206:preprotachykinin; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B