Chronic effect of datura (seed) extract on the brain of albino rats.
The effect of chronic treatment with datura (seed) extract was studied to investigate its effect on the energy metabolism and peroxidative activities in the brain of rats. Datura treatment was found to cause an increase in the activity of brain lipid peroxidase and catalase, while it caused a decrease in the activity of fructose diphosphate aldolase and glucose 6-phosphate dehydrogenase enzyme. A marked reduction was noted in the protein, DNA and RNA contents of datura administered rats.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D013286:Datura stramonium; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012313:RNA / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D009419:Nerve Tissue Proteins; D010936:Plant Extracts; D012313:RNA; D004247:DNA; D005954:Glucosephosphate Dehydrogenase; D010544:Peroxidases; D002374:Catalase; D005634:Fructose-Bisphosphate Aldolase