title: A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans).
abstract: The clinical and histopathological features of 12 female patients with Flegel's disease were studied. The onset of this dermatosis was delayed until adulthood. The eruption consisted of scaly papules 1-5 mm in diameter which developed principally on the lower legs, upper arms and pinnae. Histopathologically there were discrete foci of hyperkeratosis with some parakeratosis over an attenuated and partially spongiotic epidermis. A genetic influence in this disorder was suggested by its occurrence in sisters in two families and in a mother and daughter. Immunohistochemical and biochemical studies suggested that there is a disorder of keratinocyte proliferation in the disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D012871:Skin Diseases / Q000235:genetics / Q000473:pathology*
chemical_list: D007633:Keratins