Viral antibodies and interferon in acute psychiatric disorders.
In a prospective study of 54 patients with acute psychiatric disorders, interferon and antibodies in serum and CSF were measured to 19 microbes by the complement fixation (CF) test and to 7 viruses by enzyme immunoassay (EIA). The CF test revealed a fourfold or greater change (p less than .001) in serum antibody titers in 20 patients, and EIA showed a twofold or greater change in CSF titers in 7 patients. Pathological serum/CSF antibody ratio by EIA was observed in 8 patients. The results suggest that viral infections and inflammatory processes have significance in the etiopathogenesis of acute psychiatric disorders.
D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis* / Q000134:cerebrospinal fluid; D003168:Complement Fixation Tests; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007372:Interferons / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D001523:Mental Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D014777:Virus Diseases / Q000150:complications / Q000175:diagnosis
D000914:Antibodies, Viral; D007372:Interferons