Suramin antiviral therapy in the acquired immunodeficiency syndrome. Clinical, immunological, and virologic results.
The human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) requires reverse transcriptase for viral replication. We treated 12 patients who had acquired immunodeficiency syndrome and active HTLV-III/LAV viremia with suramin, a potent competitive inhibitor of reverse transcriptase, in six weekly induction doses of 1 g, followed by weekly maintenance doses of 500 mg. Three of eleven evaluable patients had complete inhibition of viral reverse transcriptase levels, lasting at least 18 weeks in each. Two additional patients had marked reduction in reverse transcriptase activity. Nadir serum suramin levels at the end of the induction phase correlated with the level of reverse transcriptase reduction. Toxicity included hepatic transaminase elevation, fever, malaise, rash, proteinuria, paresthesias, reversible neutropenia, and adrenal insufficiency. Objective clinical improvement was documented in 1 patient, but no patient had improvement in immune function and 7 patients had recurrent opportunistic infections. Although suramin may suppress HTLV-III/LAV viremia, its significant toxicity and lack of effect on immune variables indicate that alternative therapy will be required.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002555:Cerebrospinal Fluid / Q000382:microbiology; D017977:Deltaretrovirus / Q000201:enzymology / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies; D006801:Humans; D007962:Leukocytes / Q000145:classification; D008297:Male; D010641:Phenotype; D010865:Pilot Projects; D018894:Reverse Transcriptase Inhibitors; D013498:Suramin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D014766:Viremia / Q000188:drug therapy*
D000914:Antibodies, Viral; D015483:HIV Antibodies; D018894:Reverse Transcriptase Inhibitors; D013498:Suramin