[Dipyroxime as a blocker of ion channels activated by acetylcholine in rat skeletal muscle].
The mechanism of cholinolytic action of dipyroxime--reactivator of the phosphorylated acetylcholinesterase were investigated in the rat diaphragm muscle by voltage-clamp technique. Dipyroxime reduced the amplitude and prolonged the decay of the miniature end-plate currents (MEPC) without affecting its exponential nature. Current-voltage relationship exhibited negative conduction in the hyperpolarized region. Dipyroxime increased the voltage dependence of the time constant of MEPC decay (the membrane potential alteration necessary for e-fold change of the decay time constant reduced from 80 to 35 mV). It was concluded that dipyroxime is a very fast blocker of the open end-plate channels.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014289:Trimedoxime / Q000494:pharmacology*
D007473:Ion Channels; D010091:Oximes; D014289:Trimedoxime; D000109:Acetylcholine
Dipiroksim kak blokator ionnykh kanalov, aktiviruemykh atsetilkholinom, v skeletnoĭ myshtse krysy.