title: Ultrastructural studies of endocrine-like cells in the fundic gastric mucosa of the bullfrog, Rana catesbeiana.
abstract: This study is concerned with electron-microscopic observations on endocrine or paracrine cells in the fundic gastric mucosa of the bullfrog. Also, an attempt was made to identify the histamine-releasing cells involved in the secretagogue response. At least three distinct endocrine-like cell types were found. The classification is based on the appearance of secretory granules and other organelles, and the relationship of endocrine-like cells with other cells in the tissue. The amphibian endocrine-like cells resemble the ECL, D and EC cells of mammals. Type-I (ECL) cells showed degranulation after repeated stimulation with tetragastrin (TG), acetylcholine (ACh) and K+ depolarizing solution, all of which release histamine.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D005748:Gastric Fundus / Q000166:cytology / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D011188:Potassium / Q000494:pharmacology; D011892:Rana catesbeiana; D013758:Tetragastrin / Q000494:pharmacology
chemical_list: D013758:Tetragastrin; D000109:Acetylcholine; D011188:Potassium