Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.
We investigated the location of binding sites of pp60src-specific monoclonal antibodies by immunoprecipitating a panel of structurally altered src proteins. Two families of antibodies which recognized epitopes mapping to either amino acid residues 28 to 38 or 92 to 128 were identified. The highly conserved nature of the epitope defined by residues 92 to 128 suggests that it may represent an important functional region of the cellular src protein.
D000914:Antibodies, Viral; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000276:immunology; D000939:Epitopes / Q000032:analysis; D009154:Mutation; D015688:Oncogene Protein pp60(v-src); D009856:Oncogene Proteins, Viral / Q000276:immunology*; D012191:Retroviridae Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D009856:Oncogene Proteins, Viral; D012191:Retroviridae Proteins; D015688:Oncogene Protein pp60(v-src)