Effects of the chronic hypoxia on the developing blood-brain barrier in the chick embryo optic tectum.
The blood-brain barrier to horseradish peroxidase has been investigated microscopically and ultrastructurally in the optic tectum of hatching chicken embryos which were kept under hypoxic conditions from the 3rd incubation day. The results indicated that the weakness sites of the blood-brain barrier correspond to the tight interendothelial junctions, whose breakdown allows extravasation of the marker into limited areas of the tectum wall.
D000818:Animals; D001370:Axonal Transport; D001812:Blood-Brain Barrier; D002642:Chick Embryo; D006735:Horseradish Peroxidase; D000860:Hypoxia / Q000503:physiopathology*; D008854:Microscopy, Electron; D013477:Superior Colliculi / Q000166:cytology / Q000196:embryology* / Q000648:ultrastructure
D006735:Horseradish Peroxidase