Liver injury with perivenular fibrosis and alcoholic hyalin after pancreatoduodenectomy for pancreatic carcinoma.
We describe a patient who developed progressive hepatic failure one year after pancreatoduodenectomy for pancreatic carcinoma and died of gastrointestinal bleeding. He suffered from progressive weight loss after surgery, even though obstruction or stenosis of the gastrointestinal tract was excluded. At autopsy, the liver showed extensive perivenular fibrosis associated with variable loss of hepatocytes, perisinusoidal fibrosis, alcoholic hyalin and a lack of parenchymal regenerative activity, all of which closely resembled severe alcoholic liver disease. Stricture of both the main pancreatic duct and the pancreaticojejunostomy with almost complete loss of exocrine acini was also found, and the recurrent tumor was seen to have caused portal venous obstruction and hepatic arterial stenosis. A combination of these nutritionally unfavorable circumstances and prolonged ischemia appeared to have been responsible for the liver injury in this non-alcoholic patient.
D001344:Autopsy; D004385:Duodenostomy / Q000009:adverse effects*; D004766:Enterostomy / Q000009:adverse effects*; D006801:Humans; D006818:Hyalin / Q000503:physiopathology*; D008099:Liver / Q000033:anatomy & histology / Q000166:cytology / Q000293:injuries* / Q000473:pathology; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology*; D008108:Liver Diseases, Alcoholic / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000628:therapy*