Effect of acute cold exposure on ACTH and zinc concentrations in human plasma.
Effects of acute cold exposure (10 degrees C for 60 min) on the concentrations of adrenocorticotropin (ACTH) and zinc in plasma were investigated in seven healthy male students. There were no significant changes in total zinc, albumin-bound zinc, and alpha 2-macroglobulin-bound zinc concentrations throughout the experimental period. On the other hand, ACTH concentration increased markedly during cold exposure. In addition, a statistically significant inverse relationship existed between the changes in ACTH and albumin-bound zinc values during the experiment. These results suggest that acute cold exposure produces elevated plasma ACTH levels, with resulting zinc redistribution in the human body.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003080:Cold Temperature; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012709:Serum Albumin / Q000378:metabolism; D015032:Zinc / Q000097:blood*; D000511:alpha-Macroglobulins / Q000378:metabolism
D012709:Serum Albumin; D000511:alpha-Macroglobulins; D000324:Adrenocorticotropic Hormone; D015032:Zinc; D006854:Hydrocortisone