Silicone oil with high specific gravity for intraocular use.
Silicone oil with a higher specific gravity than that of intraocular fluid or polydimethylsiloxane may have special indications in vitreoretinal surgery. Trifluorsiloxane is such a substance, and therefore its biological compatibility was investigated in rabbit eyes. It was found that this substance was clinically well tolerated within the observation time of up to 6 months, even if there was some neovascularisation from the inferior limbus. Histologically both an inflammatory response and tissue impregnation were more pronounced than with normal polydimethylsiloxane.
D000818:Animals; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology / Q000473:pathology; D004129:Dimethylpolysiloxanes / Q000009:adverse effects*; D005123:Eye / Q000187:drug effects*; D007498:Iris / Q000473:pathology; D007499:Iris Diseases / Q000209:etiology / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000209:etiology; D011817:Rabbits; D012827:Silicone Oils; D012828:Silicones / Q000009:adverse effects*; D014821:Vitrectomy
D004129:Dimethylpolysiloxanes; D012827:Silicone Oils; D012828:Silicones; C049525:polymethyl-3,3,3-trifluoropropylsiloxane