Enhancement of interleukin-2 release in rats by treatment with bleomycin and adriamycin in vivo.
Spleen cells from rats previously injected with bleomycin (10 mg/kg) or Adriamycin (1 mg/kg) were able to release higher levels of interleukin-2 (IL-2) than cells from untreated animals. The difference in IL-2 release was detected after the cells were exposed to a suboptimal dose of concanavalin A (0.5 micrograms/ml) for 24 h. By cytofluorimetry, these drugs did not change the proportion of W3/25+ (helper) or OX-8+ (suppressor) T-cell subsets. In contrast, the immunosuppressive drug cyclophosphamide inhibited the IL-2 release from spleen cells under the same conditions. It is suggested that some anti-cancer antibiotics may be able to enhance the release of IL-2 while other cytotoxic drugs with more immunosuppressive potential could inhibit the release of this mediator.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007376:Interleukin-2 / Q000378:metabolism*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects* / Q000378:metabolism
D007376:Interleukin-2; D003208:Concanavalin A; D001761:Bleomycin; D004317:Doxorubicin; D003520:Cyclophosphamide