title: Decrease of plasma prekallikrein and kallikrein inhibitors during intravenous phlebography.
abstract: Complex contact activation systems may have major involvement in side effects of i.v. contrast media. To investigate this, quantitative measurements of several factors (plasma prekallikrein, kallikrein inhibitory activity, haematocrit, alpha-2-macroglobulin, antithrombin III, alpha-1-antitrypsin and beta-thromboglobulin) were made before and after i.v. contrast phlebography in two groups of patients (each containing 21 patients) with no thrombosis, using a high- (meglumine iodamide) and a low-osmolality (ioxaglate) contrast medium. A statistically significant decrease in plasma prekallikrein was observed after the high-osmolality contrast medium, which is a sign of the activation of the kallikrein-kinin system and an indicator of the activation of the intrinsic coagulation. These events may play an important role in the adverse effects of contrast media.
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D003287:Contrast Media / Q000633:toxicity*; D006400:Hematocrit; D006801:Humans; D007451:Iodamide / Q000031:analogs & derivatives / Q000633:toxicity*; D007458:Iodipamide / Q000031:analogs & derivatives; D007463:Iodobenzoates / Q000633:toxicity*; D007485:Ioxaglic Acid / Q000633:toxicity*; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000097:blood*; D010690:Phlebography; D011288:Prekallikrein / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D003287:Contrast Media; D007463:Iodobenzoates; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D001620:beta-Thromboglobulin; D007451:Iodamide; D000990:Antithrombin III; D011288:Prekallikrein; D007610:Kallikreins; D007458:Iodipamide; C006753:meglumine iodipamide; D007485:Ioxaglic Acid