[Effect of adaptation to short-term stress exposure on the fibrillation threshold and ectopic activity of the heart in experimental myocardial infarct].
Preliminary adaptation to short-term stress was shown to prevent the decrease in the heart fibrillation threshold and an increase in ectopic activity which is usually observed in experimental myocardial infarction. This protective effect involves an enhanced activity of the antioxidant system. Therefore, a synthetic antioxidant ionol was applied to prevent disturbances of the heart electrical stability in infarction. It was established that ionol completely prevents the decrease in the electrical threshold and the increase in ectopic activity of the heart in experimental infarction. Thus, it can be concluded that ionol possesses an antiarrhythmic effect.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology*; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000503:physiopathology*
D002084:Butylated Hydroxytoluene
Vliianie adaptatsii k korotkim stressovym vozdeĭstviiam na porog fibrilliatsii i éktopicheskuiu aktivnost' serdtsa pri éksperimental'nom infarkte miokarda.