title: Aggression and defeat-induced opioid analgesia displayed by mice are modified by calcium channel antagonists and agonists.
abstract: The effects of the calcium channel antagonists diltiazem, nifedipine and verapamil and the calcium channel agonist, BAY K 8644, on offensive and defensive aggression and defeat-induced opioid analgesia were examined in male mice in resident-intruder interactions. The calcium channel antagonists decreased and the agonist increased the aggressive behaviors displayed by the mice. In addition, the calcium channel antagonists augmented, while the agonist attenuated defeat-induced analgesia displayed by the intruder mice. These results suggest that calcium channel antagonists have inhibitory influences on aggressive behavior and may facilitate endogenous opioid activity.
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine