A division of HLA-DQw1 associated with DR1, DR1x-DQw1, DR2 short, DRw10, and DRw14. I. Definition by alloantiserum LY 1327.
We have identified an alloantiserum, LY 1327, directed against part of DQw1-positive cells. This split of DQw1 includes DR1, DR1x, DR2sh, DRw10, and DRw14; the other DQ-associated specificities, -DR2 long and DRw13, are unreactive. Segregation was ascertained in 11 informative Caucasoid families and in 33 genotyped individuals. DR1x refers to a specificity typing as DR blank DQw1, detected by certain anti-DR1 sera and recognized cellularly by HTC DwBON DR blank DQw1 (A. Cambon, Toulouse). Biochemical analysis by two-dimensional gel electrophoresis and DNA analysis by restriction fragment length polymorphism will be discussed since they support the existence of this division of DQw1.
D000939:Epitopes / Q000235:genetics; D006681:HLA-D Antigens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology*; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D015798:HLA-DR1 Antigen; D015802:HLA-DR2 Antigen; D006239:Haplotypes; D006801:Humans; D007106:Immune Sera / Q000276:immunology*
D000939:Epitopes; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015798:HLA-DR1 Antigen; C052238:HLA-DR14; D015802:HLA-DR2 Antigen; C043263:HLA-DRw10; D007106:Immune Sera; C052239:alloantiserum LY 1327