Nickel fixation by rat plasma and 21-day placental homogenates.
The effectiveness of 19-day placenta homogenates in the binding and retention of nickel was compared with that of rat plasma in a simple dialysis system. The energy of activation of both placenta and plasma were of the same range (-5 kJ/mol). The specificity of the nickel binding system was considerable, as the presence of concentrations of zinc, iron or copper five orders of magnitude larger resulted only in the loss of a maximum of 10% of the pre-bound nickel in 24 h at 20 degrees C. This strong fixation of nickel seems to be specific and is probably the same in placenta and in plasma.
D000818:Animals; D001667:Binding, Competitive; D003300:Copper / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D009532:Nickel / Q000097:blood / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism
D003300:Copper; D009532:Nickel; D007501:Iron; D015032:Zinc