The inhibition by azatadine of the immunological release of leukotrienes and histamine from human lung fragments.
The effects of the H1 antihistamine azatadine on the antigen-induced release of slow reacting substance of anaphylaxis (leukotrienes C4 and D4) and histamine from passively sensitized human lung fragments were determined. Azatadine 0.1-10 microM significantly and dose dependently inhibited the release of leukotrienes from lung by 22-71%. Histamine release was also inhibited by azatadine 10 microM.
D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D013189:SRS-A / Q000378:metabolism*
D006634:Histamine H1 Antagonists; D013189:SRS-A; D003533:Cyproheptadine; C006656:azatadine