Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions.
Unilateral 6-hydroxydopamine lesions of the mesostriatal dopaminergic system in the rat resulted in a decrease of substance P-immunoreactivity in the ventral striatum, and in a heterogeneously distributed increase of enkephalin-immunoreactivity in the dorsal and ventral striatum and the globus pallidus. The respective decrease and increase are caused by a lower or higher staining intensity of the peptidergic fibers, whereas no changes were found in the cell bodies.
D000344:Afferent Pathways / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004525:Efferent Pathways / Q000187:drug effects / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D006651:Histocytochemistry; D006892:Hydroxydopamines / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D013373:Substance P / Q000378:metabolism*
D004745:Enkephalins; D006892:Hydroxydopamines; D013373:Substance P; D016627:Oxidopamine; D004298:Dopamine