title: Irritation and staining by 10-butyryl dithranol (butantrone) in psoriasis.
abstract: An open clinical trial was carried out using butantrone ointment in the treatment of 10 patients with psoriasis in order to assess staining and irritation in relation to efficacy. At 0.5% and 1.0% strengths, butantrone produced significant levels of irritation and staining with minimal clinical response and poor patient compliance.
mesh_terms: D000293:Adolescent; D000328:Adult; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*; D013194:Staining and Labeling
chemical_list: D009824:Ointments; C038464:butantrone; D000875:Anthralin