title: Evolution of low molecular weight immunoglobulins. V. Degree of antigenic relationship between the 7S immunoglobulins of mammals, birds, and lower vertebrates to the turkey IgY.
abstract: There are close antigenic relations between the turkey IgY--the dominant 7S Ig of serum--and the corresponding IgY-like Igs of chicken, duck, goose, tortoise, and frog as well as serum or colostral IgA of man and swine. The RIA-systems used for the determination of immunological cross-reactivity among the Ig types consisted of 125-I-labelled turkey IgY and class-specific rabbit anti-turkey IgY antibodies. The results stand in a good agreement with our findings demonstrating strong antigenic relationships between various serum or colostral Igs of IgY and IgA types, respectively, to the chicken IgY. Therefore, the IgY-like Igs seem to be the precursors for the IgA class of mammals.
mesh_terms: D000818:Animals; D001001:Anura / Q000276:immunology; D001717:Birds / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology*; D008322:Mammals / Q000276:immunology*; D008970:Molecular Weight; D010802:Phylogeny; D013552:Swine / Q000276:immunology; D014422:Turkeys / Q000235:genetics / Q000276:immunology*; D014426:Turtles / Q000276:immunology
chemical_list: D000939:Epitopes; C016512:IgY; D007070:Immunoglobulin A; D007136:Immunoglobulins