Effects of galanin on 5-HT neurons in the rat CNS.
Intraventricular injections of the neuropeptide galanin were shown to induce a significant increase of endogenous 5-hydroxyindoleacetic acid (5-HIAA) levels in the occipital cortex, hippocampus and median eminence of rats. A general, but in most regions non-significant, tendency for increased 5-hydroxytryptamine (5-HT) levels was also observed. In view of the similar effects of galanin on 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the median eminence and pons-medulla and in view of previous in vitro studies, these results are compatible with a presynaptic inhibitory effect of galanin on certain central 5-HT neurons of the rat.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D019004:Galanin; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
D010455:Peptides; D017981:Receptors, Neurotransmitter; D012701:Serotonin; D019004:Galanin