title: [Effect of melittin on ion currents in heart cell membranes].
abstract: It has been shown on auricle fibres of the frog that neurotoxin from bee poison melittin suppresses the ionic currents entering the cell through calcium and sodium channels of the membrane, increases the background potassium current, suppresses phasic and tonic contraction of the fibres. Toxin modifies the kinetics of calcium channels, but does not affect activation and desensitization of beta adrenoreceptors. Effects of melittin are not decreased when adding the inhibitor of phospholipase A2 indomethacin. The results show that melittin directly affects the protein components of the membrane-ionic channels, probably binding with them.
mesh_terms: D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D008555:Melitten / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D011895:Rana ridibunda; D012964:Sodium / Q000378:metabolism
chemical_list: D001514:Bee Venoms; D007473:Ion Channels; D008555:Melitten; D012964:Sodium; D002118:Calcium; D007213:Indomethacin
vernacular_title: Deĭstvie melittina na ionnye toki membran kletok serdtsa.