Calcium and phosphate metabolism in uranyl nitrate-induced acute renal failure.
Plasma calcium regulation in uranyl nitrate-treated dogs was studied. A discrete hypercalcemia was observed without significant changes in the level of plasma ionized calcium. Serum phosphate increased markedly following uranyl nitrate treatment. A sharp rise of iPTH was demonstrated. Uranyl nitrate-induced acute renal failure in dogs was found to be a useful model for studying the mechanisms regulating calcium and phosphate metabolism.
D058186:Acute Kidney Injury / Q000097:blood* / Q000139:chemically induced; D000818:Animals; D002118:Calcium / Q000097:blood*; D004285:Dogs; D007477:Ions / Q000097:blood; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood*; D011188:Potassium / Q000097:blood; D014501:Uranium / Q000633:toxicity*; D014502:Uranyl Nitrate / Q000633:toxicity*
D007477:Ions; D010281:Parathyroid Hormone; D010710:Phosphates; D014502:Uranyl Nitrate; D014501:Uranium; D011188:Potassium; D002118:Calcium