Inhibitor of physiological interferon synthesis. I. Isolation, physiochemical and biological properties of crude inhibitor preparations.
Fast adherent fraction of peritoneal cells of Balb/c mice was shown to release the inhibitor of physiological interferon synthesis. The inhibitor appeared active in relation to interferons produced by peritoneal cells noninduced or induced with NDV or LPS, and not active in relation to a synthesis of IFN induced by NDV in L cells. The inhibitor was shown to be a low-molecular substance, relatively stable at 56 degrees C and pH 2-10.
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D009522:Newcastle disease virus; D010529:Peritoneal Cavity / Q000166:cytology / Q000378:metabolism*
D008070:Lipopolysaccharides; D007372:Interferons