Prenatal influence of substance P on blood pressure and stress sensitivity of spontaneously hypertensive rats.
Substance P, administered i.p. to female spontaneously hypertensive rats in the last 6 d of gestation, diminishes the age dependent increase of blood pressure especially in male offspring and the additionally stress related blood pressure increase in both sexes.
D000375:Aging / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011918:Rats, Inbred SHR; D012737:Sex Factors; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P