A patch clamp study of the action of ethacyzine on the rapid inward sodium current in single rat heart muscle cells.
The effect of ethacyzine (a diethylamine analogue of ethmozine) on the rapid inward sodium current (INa) was studied in single rat ventricular muscle cells by a patch clamp technique. Extracellular application of 3 microM ethacyzine depressed the INa in a use-dependent fashion. Rest recovery from the use-dependent block by ethacyzine followed an exponential time course with a time constant of about 215 +/- 40 s (n = 4, mean +/- S.E.).
D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D016293:Moricizine / Q000031:analogs & derivatives*; D009206:Myocardium / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D012964:Sodium