[Controlled atrial fibrillation and a possible mechanism of its genesis].
In experiments on cats a single premature beat or vagal stimulation shortened the effective refractory period without any spontaneous heart rate disturbances, while the combined action of these factors always led to paroxysmal tachycardia or atrial fibrillation. It is suggested that contracting myocardium possesses a covert ability for self-excitation revealed only in critical shortening of the action potential. Since the excitation occurring in such conditions is also a premature beat, the fibrillation process becomes self-maintaining.
D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology* / Q000503:physiopathology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D002415:Cats; D004558:Electric Stimulation; D012032:Refractory Period, Electrophysiological; D014630:Vagus Nerve / Q000502:physiology
Upravliaemaia fibrilliatsiia predserdiĭ i vozmozhnyĭ mekhanizm ee vozniknoveniia.