Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine.
[18F]-5-fluorocytosine-arabinoside (2) and [18F]-5-fluorocyclocytidine (4) were prepared by reaction of [18F]-acetylhypofluorite with cytosine-arabinoside (1) or cyclocytidine (3) in acetic acid and were isolated in an overall radiochemical yield of 20% and 9%, respectively. The biodistribution of both radiopharmaceuticals was determined in melanoma bearing Syrian golden hamsters. It was found that 2 is a good tumour-localizing agent for pigmented and non-pigmented Greene melanoma.
D003504:Ancitabine; D000818:Animals; D006224:Cricetinae; D003561:Cytarabine; D005437:Flucytosine; D005461:Fluorine; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging*; D008647:Mesocricetus; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D011868:Radioisotopes; D003561:Cytarabine; D005461:Fluorine; D005437:Flucytosine; D003504:Ancitabine