title: Interference with the distribution and release of arachidonic acid in human keratinocytes by bradykinin, histamine and phosphatidic acid.
abstract: The effects of bradykinin, histamine, phosphatidic acid and leukotrienes B4 and C4 on the distribution and release of 14C-arachidonic acid in human keratinocytes in culture were investigated. Bradykinin, histamine, and phosphatidic acid were found to liberate 14C-arachidonic acid from membrane phospholipids, whereas leukotrienes B4 and C4 were ineffective in this respect. The decrease in the labeling of phospholipids was accompanied by increased labeling of the non-phosphorus lipids. The present study suggests that bradykinin, histamine, and phosphatidic acid may interfere with the distribution and release of arachidonic acid in human keratinocytes in culture.
mesh_terms: D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D007975:Leukotriene B4 / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology
chemical_list: D001095:Arachidonic Acids; D010712:Phosphatidic Acids; D010743:Phospholipids; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D007633:Keratins; D006632:Histamine; D001920:Bradykinin