title: Reduced levels of histidine and urocanic acid in suction blister fluids from patients with psoriasis.
abstract: Metabolites of histidine were determined by high performance liquid chromatography in suction blister fluids from lesions and normal appearing skin of patients with psoriasis and from healthy subjects. There was a significant decrease in the levels of histidine and urocanic acid in the samples obtained from patients with psoriasis as compared to healthy subjects. Virtually only the E-isomer of urocanic acid was detected.
mesh_terms: D000328:Adult; D000368:Aged; D001768:Blister / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006639:Histidine / Q000032:analysis*; D006801:Humans; D007093:Imidazoles / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism* / Q000532:radiotherapy; D012867:Skin / Q000378:metabolism*; D014467:Ultraviolet Therapy; D014560:Urocanic Acid / Q000032:analysis*
chemical_list: D007093:Imidazoles; D006639:Histidine; D014560:Urocanic Acid