[Effect of iloprost on aggregation behavior in kidney conditioning and changes in iloprost concentration in kidney preservation].
The conditioning of the donor by 1.0 microgram/kg X min Iloprost over 15 minutes leads to a considerable inhibition of the aggregation of thrombocytes in the domestic pig. 160% more ADP had to be added than before the application of Iloprost. When 0.5 microgram/ml Iloprost are added to the perfusion fluid and to the reperfusion fluid 0.22 microgram/ml and 0.27 microgram/ml, respectively, are to be proved in the venous efflux. Whether or not the difference is absorbed or metabolized must remain open. During the 72-hour storage of the kidney in a Euro-Collins-solution with 0.5 microgram/ml Iloprost after 24 hours a decrease of 0.34 microgram/ml, after 48 hours to 0.33 microgram/ml and after 72 hours to 0.20 microgram/ml takes place. Thus Iloprost is present in an effective concentration also after 72 hours. The decrease to one plateau rather speaks for a consumption by active metabolic effect or absorption than for a chemical decomposition.
D000818:Animals; D011464:Epoprostenol / Q000378:metabolism / Q000494:pharmacology*; D016285:Iloprost; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D010974:Platelet Aggregation / Q000187:drug effects*; D013552:Swine
D011464:Epoprostenol; D016285:Iloprost
Der Einfluss von Iloprost auf das Aggregationsverhalten während der Nierenkonditionierung und Iloprostkonzentrationsveränderungen bei der Nierenkonservierung.