Suppression of in vitro haematopoiesis following human immunodeficiency virus infection.
Viral infections are frequently associated with haematological disorders. Abnormalities including leukopenia, anaemia and thrombocytopenia are commonly observed in patients with the acquired immune deficiency syndrome (AIDS) or the AIDS-related complex (ARC). The underlying cause of these haematological abnormalities is poorly understood. We report here that bone marrow progenitors isolated from AIDS or ARC patients are responsive to recombinant human granulocyte-macrophage colony stimulating factor (rGM-CSF) and recombinant erythropoietin. Antibodies present in the serum of patients infected with the human immunodeficiency virus (HIV), however, could suppress the growth of these progenitors, but not the growth of progenitors from HIV seronegative controls. A component of this immune-mediated suppression appears to be antibodies directed towards the envelope glycoprotein (gp120) of HIV.
D000386:AIDS-Related Complex / Q000503:physiopathology*; D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D000914:Antibodies, Viral / Q000276:immunology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004921:Erythropoietin / Q000494:pharmacology; D006678:HIV / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D007377:Interleukin-3; D014759:Viral Envelope Proteins; D004921:Erythropoietin; D012194:RNA-Directed DNA Polymerase