Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver.
The promoters of murine hepatocarcinogenesis phenobarbital (PB) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) given to adult C3Hf female mice increased the content of total liver DNA by 1.6-1.8-fold each week after the beginning of treatment. Both compounds increased the aminopyrine-N-demethylase activity, decreased the glucose 6-phosphatase (G6Pase), alkaline phosphodiesterase I and alkaline phosphatase specific activities, but did not modify the gamma-glutamyltransferase levels. Both compounds decreased the abundance of tyrosine aminotransferase- and metallothionein I-related RNA transcripts. These findings confirmed the PB-like activity of TCPOBOP and showed that both chemicals had a pleiotropic effect on mouse liver, that was not limited to stimulation of drug metabolism, but also affected other hepatocyte functions.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D005952:Glucose-6-Phosphatase / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008668:Metallothionein / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D010634:Phenobarbital / Q000633:toxicity*; D011725:Pyridines / Q000633:toxicity*; D012313:RNA / Q000032:analysis; D014158:Transcription, Genetic / Q000187:drug effects; D014444:Tyrosine Transaminase / Q000235:genetics; D005723:gamma-Glutamyltransferase / Q000032:analysis
D005938:Glucocorticoids; D011725:Pyridines; D012313:RNA; C028474:1,4-bis(2-(3,5-dichloropyridyloxy))benzene; D008668:Metallothionein; D005723:gamma-Glutamyltransferase; D014444:Tyrosine Transaminase; D005952:Glucose-6-Phosphatase; D010634:Phenobarbital