Protective effect of iloprost and UK 38 485 against gastric mucosal damage induced by various stimuli.
This study was undertaken to evaluate the efficacy of iloprost and UK 38485 in the prevention of gastric lesions due to restraint-cold stress, ethanol or indomethacin. Prior injection of iloprost to the rats significantly prevented the increase in ulcer index by restraint- cold stress or indomethacin but nonsignificantly reduced the ulcer index induced by ethanol. UK 38 485 at lower doses caused a highly significant decrease in the ulcer index induced by all noxious stimuli used in this study. UK 38 485 also reduced the increased 3H back diffusion due to restraint-cold stress. Higher doses of the compound, however, failed to decrease the mucosal damage due to restraint-cold stress. Combination of iloprost and UK 38 485 produced a further significant decrease in the ulcer index induced by all noxious stimuli and increased 3H back diffusion induced by restraint-cold stress. In relation to these results the importance of PGI2/TXA2 ratio in the production of gastric mucosal lesions is discussed.
D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D016285:Iloprost; D007093:Imidazoles / Q000494:pharmacology*; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control; D013312:Stress, Physiological / Q000473:pathology; D013928:Thromboxane A2 / Q000032:analysis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D007093:Imidazoles; C039242:dazmegrel; D000431:Ethanol; D013928:Thromboxane A2; D011464:Epoprostenol; D013930:Thromboxane-A Synthase; D016285:Iloprost; D007213:Indomethacin