title: Prostatic involvement in Wegener's granulomatosis.
abstract: Wegener's granulomatosis involving the prostate gland is unusual. We report 3 cases of this condition in which typical necrotizing granulomas with vasculitis were seen histologically. These lesions may cause gross hematuria or obstructive voiding, including urinary retention. Management includes prostatectomy when the symptoms are severe but an initial trial of aggressive medical therapy may be successful. Treatment requires a knowledge of the natural history of Wegener's granulomatosis and its usual response to medical therapy.
mesh_terms: D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
chemical_list: D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone