title: A role of calcium in altered sodium ion transport of hypertensives?
abstract: Research on the etiology of essential hypertension has led to many reports of altered ion transport in cells from hypertensive patients and animal models. Abnormalities in sodium and calcium ion gradients and transport in vascular smooth muscle, neuronal tissue, cardiac muscle as well as erythrocytes have been extensively investigated. It is not clear whether these abnormalities are of primary or secondary nature. The current knowledge of sodium and calcium ion transport in essential hypertension is briefly reviewed here. Furthermore, evidence is presented which suggests a role of calcium in the regulation of sodium transport activity.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology*; D002412:Cations; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D008094:Lithium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D002412:Cations; D007473:Ion Channels; D008094:Lithium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium