Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca.
An unpreserved artificial tear substitute containing 0.1% sodium hyaluronate was compared with a preparation containing 1.4% polyvinyl alcohol and 0.5% chlorobutanol in a controlled, double-masked, randomized study in patients with moderately severe keratoconjunctivitis sicca. Patients were evaluated initially, at 1, 4, and 8 weeks. The dry-eye status was evaluated by means of tear-film osmolality, tear breakup time, rose bengal staining, Schirmer's test (without anesthesia), and ocular surface-impression cytology. In general, neither preparation was found to be superior to the other. In both study groups, the mean tear-film osmolality and rose bengal staining score improved over the eight-week study, but the degree of squamous metaplasia of the bulbar conjunctival surface, as shown by impression cytology, did not change significantly.
D002986:Clinical Trials as Topic; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy* / Q000473:pathology; D009994:Osmolar Concentration; D010166:Palliative Care; D011142:Polyvinyl Alcohol / Q000627:therapeutic use*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000627:therapeutic use*; D012395:Rose Bengal; D013194:Staining and Labeling
D012395:Rose Bengal; D011206:Povidone-Iodine; D011142:Polyvinyl Alcohol; D006820:Hyaluronic Acid; D011205:Povidone