title: CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication.
abstract: Lymphocytes bearing the CD8 marker were shown to suppress replication of human immunodeficiency virus (HIV) in peripheral blood mononuclear cells. The effect was dose-dependent and most apparent with autologous lymphocytes; it did not appear to be mediated by a cytotoxic response. This suppression of HIV replication could be demonstrated by the addition of CD8+ cells at the initiation of virus production as well as after several weeks of virus replication by cultured cells. The observations suggest a potential approach to therapy in which autologous CD8 lymphocytes could be administered to individuals to inhibit HIV replication and perhaps progression of disease.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy; D000954:Antigens, Surface; D002478:Cells, Cultured; D006678:HIV / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008297:Male; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication
chemical_list: D000954:Antigens, Surface; D012194:RNA-Directed DNA Polymerase