[Secondary immune response of mice immunized with a protein-cellulose complex].
It has been previously established that an intravenous injection of a protein antigen solution into mice primed with the same antigen in the form of a protein-cellulose complex induces an intensive antibody production (up to 10,000 antibody-forming cells/10(6) splenocytes and up to 3 mg of antibodies/ml of serum). The present study has shown that secondary immune response can be considerably enhanced if large amounts of the antigen are administered intraperitoneally in a protein-cellulose complex during secondary immunization. In these experiments the mean number of antibody-forming cells was 50.000/10(6) splenocytes and the antibody serum level averaged 10 to 12 mg/ml. The effect persisted for a long time: as late as on day 80 the antibody concentration was 2 mg/ml of serum.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000921:Antibody-Producing Cells / Q000276:immunology; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization / Q000379:methods*; D007117:Immunization, Secondary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology*
D000906:Antibodies; D002483:Cellulose, Oxidized; D005719:gamma-Globulins; D002482:Cellulose
Vtorichnyĭ immunnyĭ otvet u mysheĭ pri immunizatsii belkovo-tselliuloznym kompleksom.