[Effect of Woodward's reagent K on tetrodotoxin-sensitive sodium channels of spinal ganglion neurons of the rat].
Currents through "fast" (tetrodotoxin-sensitive) sodium channels in rat sensory neurons were measured before and after external application of solutions containing 10 mM Woodward's reagent K (pH 6.0). The membrane treatment has resulted in irreversible changes of stationary activation and inactivation parameters.
D000818:Animals; D005727:Ganglia, Spinal / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007555:Isoxazoles / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D011901:Ranvier's Nodes / Q000187:drug effects; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D007473:Ion Channels; D007555:Isoxazoles; D010080:Oxazoles; C009686:N-ethyl-5-phenylisoxazolium-3'-sulfonate; D013779:Tetrodotoxin; D012964:Sodium
Vliianie reagenta Vudvarda K na tetrodotoksinchuvstvitel'nye natrievye kanaly neĭronov spinal'nykh gangliev krysy.