[Value of the basophil stimulation test in the diagnosis of juvenile bronchial asthma].
The diagnostic value of histamine liberation from basophil granulocytes (BST) was investigated in asthmatic children with house dust, house dust mite or moulds allergy. BST corresponded at about 80% to skin prick test (PRICK) and radio-allergo-sorbens test (RAST) in 178 patients. The relevance of the results of BST, PRICK and RAST for the asthmatic symptoms was proved by bronchial provocation in 77 children. BST corresponded clearly better to the inhalation test than PRICK and RAST. Correspondence of BST in house dust mite allergy amounted to 94%, in house dust allergy to 100%, and in moulds allergy to 77%. Overall correspondence of BST was 92%. Even when RAST and PRICK showed different results correspondence of BST attained 91%. In cases with identical results of BST, PRICK and RAST the bronchial provocation test corresponded in 98%. It is concluded, that if history fits to BST, RAST and PRICK bronchial provocation is no longer essential for the diagnosis of relevant allergens in perennial childhood asthma. This seems to hold also in cases of house dust or house dust mite allergy, where the result of PRICK or RAST is different. Especially in childhood the use of BST in the diagnostic procedure provides the following advantages: risks of bronchial provocation and the necessary hospitalisation can be avoided, cooperation of the patient is not needed, and costs can be reduced.
D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology; D001491:Basophils / Q000276:immunology*; D002648:Child; D006636:Histamine Release; D006801:Humans; D007428:Intradermal Tests; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis
D000485:Allergens
Stellenwert des Basophilenstimulationstestes in der Diagnostik des kindlichen Asthma bronchiale.