Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron.
The patch-clamp technique was used to record from cell-attached patches located on the somas of postnatal rat retinal ganglion cells in culture. Single-channel currents that were activated by internal calcium and permeable to multiple cations were found to open for prolonged periods of time (on the order of minutes) in cells that were actively regenerating processes but not in cells that lacked processes. These findings confirm the notion that the level of intracellular Ca2+ rises in neurons that are regenerating processes and suggests that the activity of the cation-selective channels may be linked to neurite regeneration in the mammalian central nervous system.
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002412:Cations / Q000378:metabolism*; D003712:Dendrites / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D009416:Nerve Regeneration; D051381:Rats; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000378:metabolism / Q000502:physiology*
D002412:Cations; D007473:Ion Channels; D002118:Calcium