[Mechanisms of the stimulating effect of brain antibodies on the Ca2 current in the neuron membrane].
Antibodies against rat brain microsomes induce a 16 +/- 3% increase in the amplitude of Ca-current (ICa) in snail neurons. Ca-ions block ICa in dose-dependent and potential-dependent manner. Antibodies against microsomes decrease the effectiveness of ICa blockade by Ca-ions: a 85 +/- 10% increase in ICa is observed and I-V curve is normalized. It is suggested that an enhancing effect of antibodies on ICa and the elimination of blocking Ca-effect on ICa are connected with the weakening of divalent cations binding by the anionic groups of calcium channels.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000276:immunology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000276:immunology*; D008861:Microsomes / Q000276:immunology; D009474:Neurons / Q000276:immunology; D051381:Rats; D012908:Snails
D000906:Antibodies; D007473:Ion Channels; D002118:Calcium
Izuchenie mekhanizmov stimuliruiushchego vliianiia protivomozgovykh antitel na Ca2+-toki neĭronal'noĭ membrany.