The content of immunoglobulins, auto-antibodies, myocardial antigen and immune complexes in patients with ischaemic heart disease in relationship to the state of circulation.
The indicators of humoral immunity in relationship to the state of circulation were studied in 116 patients with ischaemic heart disease (IHD). The amount of complement, auto-antibodies and antigen was determined according to the complement consumption reaction, immune complexes were studied using the method of selective precipitation in polyethylene glycol, immunoglobulins (Ig) by the method of radial immunodiffusion. Patients with chronic IHD presented pronounced changes in humoral immunity indicators in comparison with healthy subjects: an elevated content of auto-antibodies, antigen, IgA, IgM and immune complexes. The level of auto-antibodies and antigen was 2-3 times higher than in controls. Among antibodies, the myocardial auto-antibodies predominated. A relationship was found between changes in the investigated indicators and the degree of circulatory failure.
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001775:Blood Circulation; D003165:Complement System Proteins / Q000276:immunology; D003327:Coronary Disease / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D000939:Epitopes; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D000939:Epitopes; D007136:Immunoglobulins; D003165:Complement System Proteins