Heparin and phenprocoumon inhibit kappa-carrageenin induced thrombosis in rats.
The tail thrombosis after kappa-carrageenin injection in rats was significantly inhibited by heparin and phenprocoumon. Heparin was yet effective at doses as low as 150 IU/kg. The present data point to an involvement of blood coagulation in this new model. Injection of cobra venom factor with complement depletion caused no thrombosis inhibition. The differences between the present kappa-carrageenin induced thrombosis model and a disseminated intravascular coagulation after lambda-carrageenin are discussed.
D015110:4-Hydroxycoumarins / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002351:Carrageenan; D003864:Depression, Chemical; D004546:Elapid Venoms / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D010644:Phenprocoumon / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control
D015110:4-Hydroxycoumarins; D004546:Elapid Venoms; C016310:cobra venom factor; D002351:Carrageenan; D006493:Heparin; D010644:Phenprocoumon