The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genes.
The c-fos proto-oncogene and H-2K class I major histocompatibility antigens are differentially expressed in low-metastatic Lewis lung carcinoma clones, but not in high-metastatic clones. Interferons induce mRNA expression of fos and H-2 in non-expressor cells and elevate mRNA steady state levels of expressor cells. Transfection of non-expressor cells by v-fos or c-fos genes induces the transcription of H-2K mRNA and elevates the levels of H-2 proteins, but not of other gene products. These results, correlated with observations in other cell systems, suggest that the c-fos proto-oncogene controls the expression of MHC genes coding for class 1 antigens.
D000199:Actins / Q000235:genetics; D000818:Animals; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D007372:Interferons / Q000494:pharmacology; D008745:Methylation; D051379:Mice; D009362:Neoplasm Metastasis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D014158:Transcription, Genetic
D000199:Actins; D006183:H-2 Antigens; D011518:Proto-Oncogene Proteins; D007372:Interferons