The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P.
The contractile response to substance P in-vitro is greater in strips of guinea-pig bladder freed of mucosa than in normal strips, while the response to field stimulation, histamine or KCl is unaffected by the presence of mucosa. Substance P has no inhibitory effect on histamine-induced contractions of the guinea-pig bladder. These findings support the possibility that the presence of mucosa may reduce accessibility of substance P to the muscle layer.
D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009092:Mucous Membrane / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D018039:Receptors, Tachykinin; D013373:Substance P / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects
D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D013373:Substance P; D011189:Potassium Chloride