Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine.
We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As previously reported, L-glu and ACh, but not SP elicited dose-dependent arterial hypotension. The data support a putative role for SP in visceral reflexes mediated by vagal nerves.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure; D005769:Gastrointestinal Motility; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology
D005971:Glutamates; D013373:Substance P; D018698:Glutamic Acid; D000109:Acetylcholine