title: [Hereditary drusen in Bruch's membrane].
abstract: The left eye of a 71-year-old patient who had suffered from choroiditis guttata was removed immediately after death by enucleation. Histopathological studies revealed numerous nodular (hard) drusen, a wide variety of senile alterations of the pigment epithelium and Bruch's membrane, and the presence of multiple corpora arenacea in the subarachnoid space of the optic nerve. A new hypothesis concerning the development of hereditary drusen is advanced, postulating a disturbance of the lysosomal enzyme/inhibitor balance.
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000473:pathology; D002829:Choroid / Q000473:pathology; D002833:Choroiditis / Q000235:genetics* / Q000473:pathology; D002924:Ciliary Body / Q000473:pathology; D003315:Cornea / Q000473:pathology; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000473:pathology
vernacular_title: Hereditäre Drusen der Bruchschen Membran.