title: Induction of angiogenesis by mixtures of two angiogenic proteins, angiogenin and acidic fibroblast growth factor, in the chick chorioallantoic membrane.
abstract: The chick chorioallantoic membrane assay was employed to assess the angiogenic response induced by mixtures of human angiogenin with bovine heparin-binding acidic fibroblast growth factor. Statistical evaluation of data accumulated at several molar ratios of the two proteins indicate that the angiogenic activity observed is neither an additive nor a synergistic resultant of the activities of the proteins separately. The possibility exists, however, that at an approximately 1:1 mole ratio an apparent inhibitory effect can be observed. Mechanisms which could underlie such observed effects are discussed.
mesh_terms: D000482:Allantois / Q000098:blood supply* / Q000187:drug effects; D043925:Angiogenesis Inducing Agents / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply* / Q000187:drug effects; D005321:Extraembryonic Membranes / Q000098:blood supply*; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D009389:Neovascularization, Pathologic
chemical_list: D043925:Angiogenesis Inducing Agents; D006133:Growth Substances; D005346:Fibroblast Growth Factors