Malignant fibrous histiocytoma associated with peripheral blood eosinophilia. In vitro studies demonstrating tumor-derived eosinophilopoietic activity.
Peripheral blood eosinophilia is a well-recognized paraneoplasia in many kinds of hematological and nonhematological malignancies. We report the case of a patient with a malignant fibrous histiocytoma. With increasing tumor burden, the patient developed a marked peripheral blood eosinophilia. Using an in vitro assay for growth of eosinophilic colonies, both the serum and the tumor of the patient proved to contain an eosinophilopoietic activity.
D002455:Cell Division; D003114:Colony-Forming Units Assay; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000097:blood / Q000473:pathology* / Q000601:surgery; D006649:Histocompatibility Antigens / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007147:Immunoglobulin Light Chains / Q000032:analysis; D017493:Leukocyte Common Antigens; D007958:Leukocyte Count; D007964:Leukocytosis / Q000473:pathology; D008875:Middle Aged; D012086:Reoperation; D013194:Staining and Labeling; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery
D006649:Histocompatibility Antigens; D007147:Immunoglobulin Light Chains; D017493:Leukocyte Common Antigens