Amiloride-sensitive sodium channels and expression of sodium appetite in rats.
Lingual application of amiloride hydrochloride blocks a sodium transport system in the mammalian gustatory system. Effects of exposure to amiloride on subsequent licking for 3% NaCl by rats were found to differ as a function of the animal's sodium balance. Licking for 3% NaCl was significantly increased in sodium-replete rats and significantly decreased in sodium-deplete rats by amiloride pretreatment. In fact, expression of sodium appetite was virtually eliminated by pretreatment with amiloride. This suggests that the recognition of sodium solutions in animals with a sodium deficit is dependent on amiloride-sensitive sodium transport at the taste bud.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects; D005665:Furosemide / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride
D007473:Ion Channels; D012965:Sodium Chloride; D000584:Amiloride; D005665:Furosemide; D012964:Sodium