[Metabolic regulation of neuron functions].
A short analytical review of Soviet and foreign studies devoted to metabolic regulation of neuron functioning is presented. It is shown that the electrical activity of neuron is accompanied by structural changes and an increase in RNA content. It is assumed that these changes are initiated by calcium ions, coming to the neuron during its excitation. The principles of metabolic regulation of functioning of electro- and chemoexcitable neuronal membranes are considered. It is shown that the metabolic reactions can be an intermediate between the activated chemoreceptor and the electrical response of the cell. Evidence is presented that the electroexcitable and chemosensitive structures in the membrane modulate each other. The role of intracellular messengers in regulating the activity of receptors and channels is considered. Possible mechanisms for their modifications under the influence of cellular factors are discussed. It is shown that the work of neuron is controlled by several metabolic regulatory systems simultaneously.
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D013570:Synaptic Membranes / Q000378:metabolism*
D007473:Ion Channels
Metabolicheskaia reguliatsiia raboty neĭrona.