Immunological study of cross-reactive polysaccharide antigens (types a, d, and h) of oral Streptococcus spp. with monoclonal antibodies.
Two monoclonal antibodies against the cross-reactive antigens of S. cricetus (type a) and S. sobrinus (type d) were isolated. Galactose and especially melibiose inhibited the precipitin reaction markedly. Inhibition by melibiose was over 200-fold stronger than that by galactose. This may indicate that galactose-alpha 1, 6-glucose is the predominant antigenic determinant of this cross-reactive antigen. This antigen was also found in S. sobrinus type h strains, but no antigen was found in one type d strain (OMZ176).
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology*; D002240:Carbohydrate Sequence; D003429:Cross Reactions; D000939:Epitopes; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000939:Epitopes; D011135:Polysaccharides, Bacterial