[Bioamines of the sympathetic nervous system of the normal rat thyroid and in merkazolil exposure].
According to histochemical data (Falck method in modification), cytofluorimetric analysis, as well as the results of regressive modelling, localization and quantitative interaction of bioamines in the sympathetic nervous plexuses of the rat thyroid gland have been estimated. In the intact state a relatively firm correlation between serotonin and catecholamine concentrations is revealed in all parts investigated in the intraorganic nervous apparatus. Effect of thyrostatic--merkazolil--results in development of certain discrepancy between intensification of bioamines uptake and ability of thyrocytes to their functionally useful utilization. A suggestion is made that dynamic equilibrium of serotonin and catecholamines ratio in the thyroid sympathetic nervous fibers is one of the factors for maintenance of the function-proliferative balance of the gland working elements at the level, adequate to the active situation.
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D005434:Flow Cytometry; D006651:Histocytochemistry; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D013956:Antithyroid Agents; D001679:Biogenic Amines; D002395:Catecholamines; D012701:Serotonin; D008713:Methimazole
Bioaminy simpaticheskogo nervnogo apparata shchitovidnoĭ zhelezy krysy v norme i pri deĭstvii merkazolila.