Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions.
With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p less than or equal to 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.
D000818:Animals; D001344:Autopsy; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage* / Q000627:therapeutic use; D003911:Dextrans / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D007552:Isotonic Solutions / Q000008:administration & dosage; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008866:Microsurgery / Q000379:methods; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D000077325:Ringer's Lactate; D012996:Solutions; D000267:Tissue Adhesions / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery
D003911:Dextrans; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012996:Solutions; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium