title: Tityus serrulatus toxin VII bears pharmacological properties of both beta-toxin and insect toxin from scorpion venoms.
abstract: Some beta-toxins from the South American scorpion Tityus serrulatus (e.g. Ts VII) are highly toxic both for mouse and fly larva. Radioiodinated Ts VII and the insect toxin from the North African scorpion Androctonus australis Hector (AaH IT) bind to the same site on a house fly head synaptosomal fraction. These results reinforce the hypothesis about the existence of a correlated series of scorpion toxins as previously defined by amino acid compositions and sequences, and immunological and circular dichroism studies, in suggesting that Ts VII constitutes a link which may fill the pharmacological gap existing between beta-toxins and insect toxins such as AaH IT.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D006793:Houseflies; D007473:Ion Channels / Q000378:metabolism; D051379:Mice; D011487:Protein Conformation; D011950:Receptors, Cholinergic / Q000032:analysis; D012604:Scorpion Venoms / Q000032:analysis / Q000633:toxicity*; D015222:Sodium Channels; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D007473:Ion Channels; D011950:Receptors, Cholinergic; D012604:Scorpion Venoms; D015222:Sodium Channels; C029574:scorpion toxin receptor; C003609:tityustoxin