Interferon producing activity of lymph-node and peripheral blood lymphocytes in cancer patients.
The IFN producing activity of RLNL and PBL was studied in cancer patients using K562, PHA-P and OK-432 as inducers. In response to K562, IFN production was significantly greater in the PBL than in the RLNL, and the titer was about equal in the PBL and RLNL when OK-432 was used as an inducer. On the contrary, the amount of IFN produced by PHA-P was significantly higher in the RLNL than in the PBL. There was no definite relationship recognized between tumor progression and IFN productivity in the cases studied.
D000328:Adult; D000368:Aged; D002460:Cell Line; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D004915:Leukemia, Erythroblastic, Acute; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D010844:Picibanil / Q000494:pharmacology; D012004:Rectal Neoplasms / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
D010835:Phytohemagglutinins; D010844:Picibanil; D007372:Interferons