An abnormality in the human cochlear vasculature in a case of cis-platinum ototoxicity.
The histopathological findings of a study of a human temporal bone are reported. The subject of this study was treated with cis-platinum in combination with bleomycin. High-frequency audiometry was performed pre- and post treatment. Microdissection for surface preparation was carried out after death. An unusual blood vessel in the cochlea was found. The possible cause of this vascular abnormality in the human cochlea is discussed.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D001299:Audiometry; D002945:Cisplatin / Q000009:adverse effects*; D003051:Cochlea / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000139:chemically induced* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy
D002945:Cisplatin