title: The effects of intravenous infusion of solutions with different colloid osmotic pressures on rat mesenteric lymph pressure.
abstract: The effects of intravenous infusion of solutions of varied colloid osmotic pressure on mesenteric lymph pressure were measured by a glass micropipette. The lymph pressure was 4.0 +/- 1.6 cm H2O between the second and third valve of rat mesenteric lymphatic vessels with diameter of 101 +/- 25 micron (mean +/- SD). Intravenous infusion of 1 ml/100g body weight (B.W.) of isotonic saline, 5% glucose solution, and 20% glucose solution increased the lymph pressure by 1.6 +/- 0.5 cm H2O, 1.5 +/- 0.3 cm H2O and 2.0 +/- 1.0 cm H2O, respectively. Infusion of 2 ml/100g B.W. of the same solutions increased the lymph pressure by 3.3 +/- 1.3 cm H2O, 3.3 +/- 1.6 cm H2O and 3.7 +/- 0.8 cm H2O, respectively. Infusion of hydroxyethyl starch solution, with colloid osmotic pressure of 25 mmHg, minimally altered the lymph pressure. One ml/100g B.W. infusion of low molecular weight dextran solution, with colloid osmotic pressure of 162 mmHg, decreased the lymph pressure by 1.3 +/- 0.9 cm H2O, and 2 ml/100g B.W. infusion of this solution decreased the lymph pressure by 2.0 +/- 1.0 cm H2O. The different effects on lymph pressure derive from the differences in colloid osmotic pressure of these solutions in conformity with the Starling hypothesis.
mesh_terms: D000818:Animals; D003102:Colloids / Q000008:administration & dosage / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007262:Infusions, Intravenous; D008198:Lymph Nodes / Q000187:drug effects* / Q000502:physiology; D008208:Lymphatic System; D008297:Male; D008643:Mesentery; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D013213:Starch / Q000494:pharmacology
chemical_list: D003102:Colloids; D003911:Dextrans; D012965:Sodium Chloride; D013213:Starch; D005947:Glucose