[Experimental study of the immunostimulating properties of tomitsid].
Tomicide, a preparation with antibacterial properties, accumulates in the culture medium during the growth of one of streptococcal strains. The injection of the preparation into mice simultaneously with the antigen (sheep red blood cells) produces an adjuvant effect. Tomicide has been found capable of inducing the production of interferon detected in the serum of the animals. During experimental stress created by intensive exercise tomicide prevented a decrease in the normal (anamnestic) level of antibodies, produced an immunostimulating effect and, at the same time, enhanced the total physical endurance of the animals, manifested by an increased duration of swimming.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000906:Antibodies / Q000032:analysis; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity / Q000187:drug effects; D001430:Bacteriocins; D003017:Clostridium tetani / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000097:blood; D051379:Mice; D010807:Physical Endurance / Q000187:drug effects; D013210:Staphylococcus / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000906:Antibodies; D000907:Antibodies, Bacterial; D001430:Bacteriocins; D007369:Interferon Inducers; C026129:tomicide; D007372:Interferons
Eksperimental'noe izuchenie immunostimuliruiushchikh svoĭstv tomitsida.