title: [The nature of the influenza C virus receptor and the specificity of the receptor-destroying enzyme].
abstract: Bacterial neuraminidases destroy influenza C virus receptors of chick erythrocytes and inactivate hemagglutination inhibitors: rat alpha 1-macroglobulin (RMG) and bovine submaxillary mucin (BSM). These data indicate that neuraminic acid may be a component of influenza C virus receptor. The inhibiting activity of RMG and BSM is also eliminated by the receptor-destroying enzyme (RDE) of influenza C virus. After inactivation, the inhibitors (RMG and BSM) contain a reduced amount of N-acetyl-9-0-acetylneuraminic acid (Neu5, 9Ac2) and a larger amount of N-acetylneuraminic acid (Neu5 Ac). Transformation of Neu5, 9Ac2 into Neu5 Ac may also occur upon incubation of free neuraminic acid with influenza C virus. These data indicate that the RDE of influenza C virus is neuraminate-O-acetylesterase (N-acyl-9 4-O-acetylneuraminate O-acetylhydrolase (EC 3.1.1.53). It was shown that inhibition of influenza C virus hemagglutination by RMG and BSM and, apparently, adhesion of the virus to the cell surface involves binding of influenza C virus with Neu5, 9Ac2.
mesh_terms: D000115:Acetylesterase / Q000378:metabolism; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002417:Cattle; D006387:Hemagglutination, Viral / Q000187:drug effects; D009982:Gammainfluenzavirus / Q000187:drug effects / Q000201:enzymology*; D009077:Mucins / Q000494:pharmacology; D019158:N-Acetylneuraminic Acid / Q000031:analogs & derivatives*; D009438:Neuraminic Acids / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009975:Orthomyxoviridae / Q000201:enzymology*; D051381:Rats; D011991:Receptors, Virus / Q000187:drug effects / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism / Q000494:pharmacology; D013379:Substrate Specificity; D000511:alpha-Macroglobulins / Q000494:pharmacology
chemical_list: D009077:Mucins; D009438:Neuraminic Acids; D011991:Receptors, Virus; D012794:Sialic Acids; D000511:alpha-Macroglobulins; C036137:2-deoxy-2,3-dehydro-N-acetylneuraminic acid; C025676:9-O-acetyl-N-acetylneuraminic acid; D002265:Carboxylic Ester Hydrolases; D000115:Acetylesterase; C046298:sialate O-acetylesterase; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid
vernacular_title: Priroda retseptora virusa grippa C i spetsifichnost' retseptorrazrushaiushchego énzima.