Plasma histamine levels in rats treated with trypanocidal diamidines.
The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D004133:Diminazene / Q000494:pharmacology; D006632:Histamine / Q000097:blood*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D010419:Pentamidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014344:Trypanocidal Agents / Q000494:pharmacology*
D000578:Amidines; D014344:Trypanocidal Agents; D010419:Pentamidine; D006632:Histamine; D004133:Diminazene