title: Palmoplantar keratoderma in association with myxedema.
abstract: A 63-year-old female who had been suffering from intractable palmoplantar keratoderma for 13 years was found to have myxedema. Shortly after institution of substitution therapy with thyroid hormone there was a striking improvement in her condition. The possibility of a causal relationship between hypothyroidism and hyperkeratosis is suggested.
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009230:Myxedema / Q000150:complications* / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D013963:Thyroid Hormones / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones