[Cerebrospinal fluid beta-endorphin in congenital insensitivity to pain].
Spontaneously elevated nociceptive threshold levels were markedly diminished after Naloxone injections in 4 patients with congenital insensitivity to pain. This finding suggested the hypothesis of a relation between congenital insensitivity to pain and permanent hyperfunction of an endomorphinic system. Radio-immunoassay of CSF beta-endorphin was performed in all 4 cases. The normal or only slightly elevated levels cannot explain electrophysiologic findings, but as a function of the multiplicity of endogenous opioid systems, hyperactivity of another endomorphinic system cannot be excluded. Other hypotheses may also be proposed.
D004723:Endorphins / Q000134:cerebrospinal fluid* / Q000502:physiology; D006801:Humans; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D000699:Pain Insensitivity, Congenital / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D011863:Radioimmunoassay / Q000379:methods; D012684:Sensory Thresholds / Q000187:drug effects; D001615:beta-Endorphin
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin
Béta-endorphine du liquide céphalo-rachidien au cours de l'insensibilité congénitale à la douleur.