title: Clearance studies on the renal action of porins extracted from Salmonella typhimurium.
abstract: The effects of porins on renal hemodynamics and on the renal handling of salt and water were studied in rats. The animals injected with 100 micrograms/kg of porins showed an important change in renal potassium handling. In fact the total potassium excretion decreased significantly (p less than 0.02) from 1.11 +/- 0.13 to 0.495 +/- 0.069 muEq/min/100 g and was significantly associated to a reduction of fractional potassium excretion from 21.6 +/- 4.1% to 12.53 +/- 0.95% (p less than 0.001). It is speculated that porins have the capability to close the potassium channels.
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D018272:Porins; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium; D012964:Sodium / Q000378:metabolism; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D007473:Ion Channels; D018272:Porins; D012964:Sodium; D011188:Potassium