The effect of cortisol on the plastic synapses in the developing mouse brain.
We studied the effect of cortisol on the plastic synapses in the hippocampal region of the developing mouse brain. Ethanolic phosphotungustic acid-stained synaptic junctions were reduced in the cortisol-treated mouse brain dose-dependently and irreversibly. The steroid therapy in infancy requires circumspection.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009473:Neuronal Plasticity / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D013194:Staining and Labeling; D013569:Synapses / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure
D006854:Hydrocortisone