[Changes in the expression of prekeratins with molecular weight of 55 and 40 kD in monolayer epithelium during skin morphogenesis in rats].
It has been shown by indirect immunofluorescence using monoclonal antibodies against adult rat simple epithelial prekeratins with the molecular weight of 55 kD (PK55) and 40 kD (PK40) that PK55 was expressed in the covering ectoderm until the 11th day of the antenatal period. PK55 expression markedly increased in ectodermal cells lining the heart region, with PK40 appearing in the same cells on day 11. Beginning from the 16th day gradual loss of both prekeratins started with the parallel formation of squamous differentiated epidermis. These proteins were retained in the outer layers of peridermal cells and in some cells of the basal layer (probably Merkel cells). PK55 was re-expressed on the 18th day in cells migrating into dermal layer during hair folliculi formation. PK55 disappeared again in mature folliculi. Thus, a correlation between distinct morphogenetic events and PK55 and PK40 expression has been found.
D000818:Animals; D004848:Epithelium / Q000196:embryology; D005260:Female; D007633:Keratins / Q000032:analysis*; D008297:Male; D008970:Molecular Weight; D009024:Morphogenesis; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000196:embryology*
D011498:Protein Precursors; C004818:prekeratin; D007633:Keratins
Izmeneniia ékspressii prekeratinov odnosloĭnogo épiteliia s mol. massami 55 i 40 kD pri morfogeneze kozhi krys.