Three types of muscarinic conductance changes in sympathetic neurons discriminately evoked by the different concentrations of acetylcholine.
Three different types of changes in membrane conductance were induced in isolated mammalian sympathetic neurons by the muscarinic actions of acetylcholine at different levels of concentration. These include a voltage-independent increase and two decreases, voltage-dependent and -independent, respectively. Muscarinic receptors in sympathetic neurons are thus shown to be coupled to multiple ionic channels, even within a single cell, and controlled by the different concentrations of a neurotransmitter.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D007473:Ion Channels; D011976:Receptors, Muscarinic; D000109:Acetylcholine