Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1.
We report the identification and partial sequence for a human salivary amylase gene, Amy1. The genomic sequence was compared with known human pancreatic and salivary amylase cDNA sequences and another salivary amylase gene sequence. While most of the intron/exon structure and coding sequences are highly similar to other amylase DNAs, the bulk of the 5' end varies significantly. Major differences in the positions and structures of promoters between human and mouse Amy1 genes suggest that there are important differences between the tissue-specific expressions in the two mammals. Some potential enhancer sequences were identified.
D000595:Amino Acid Sequence; D000681:Amylases / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012469:Salivary Glands / Q000201:enzymology; D012689:Sequence Homology, Nucleic Acid
D004247:DNA; D000681:Amylases