[The role of the cooperative effect of lipoproteins and hormones in the regulation of the lysosomal apparatus of the cell].
Cooperative effect of hydrocortisone, adrenaline and high density lipoproteins was found in initiation of the lysosomotropic induction of protein synthesis in liver tissue. Translocation of lysosomes into perinuclear area and transfer of lysosomal hydrolases into nuclei were responsible for specificity of the effect. As a result of consecutive action of carboxylic, serine and thiol proteinases activation of chromatin was induced in nuclei. These processes were inhibited by pepstatin, hordox and iodoacetamide, respectively, as well as by vinblastine--inhibitor of intracellular transport. Actinomycin D inhibited completely the elevated synthesis of RNA and protein under these conditions. The cooperative effect studied appears to be involved in physiological regeneration of liver cells under conditions of their increased functional activity.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002402:Cathepsin D / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004837:Epinephrine / Q000502:physiology*; D005260:Female; D006854:Hydrocortisone / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood / Q000502:physiology*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology* / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D002843:Chromatin; D008075:Lipoproteins, HDL; D012313:RNA; D004247:DNA; D000135:Acid Phosphatase; D002402:Cathepsin D; D006854:Hydrocortisone; D004837:Epinephrine
Rol' kooperativnogo éffekta lipoproteinov i gormonov v reguliatsii lizosomal'nogo apparata kletok.