Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.
In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation. Brief courses of FK for one to four days preoperatively, and especially beginning four days postoperatively, allowed long subsequent survival of heart grafts in otherwise untreated recipients. The seeming acceptance of the grafts with postoperative FK treatment was largely but not exclusively donor specific when tested eight days after the last FK dose by second grafts from the same donor v third-party donor grafts. FK in minimally therapeutic doses was synergistic with suboptimal doses of CyA.
D000005:Abdomen; D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D016559:Tacrolimus
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011725:Pyridines; D016559:Tacrolimus