title: Is the K permeability of the resting membrane controlled by the excitable K channel?
abstract: To test whether or not the potassium permeability of the resting membrane is controlled by the excitable K channels (delayed rectifier), we examined changes in the Na and K permeability ratio, PNa/PK, of the squid axon before and after the excitable K channels were blocked. The blockage of the K channels was accomplished by three independent methods: internal application of tetraethylammonium, internal application of 4-aminopyridine plus Cs, and prolong internal perfusion of NaF solution. The permeability ratio was determined using two different methods: the conventional electrophysiological method and a new method based on the measurements of the hyperpolarizing effect of Na removal. We found that blocking the K channels did not cause a proportional decrease in the K permeability of the resting membrane, suggesting that the semipermeable property of the resting membrane is not determined by the excitable K channels.
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002463:Cell Membrane Permeability; D049832:Decapodiformes; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D012964:Sodium; D011188:Potassium