NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG).
We studied Leu 7+ cell distribution and natural killer (NK) activity in the peripheral blood of six patients who had peripheral neuropathy and monoclonal IgM protein directed against myelin-associated glycoprotein (anti-MAG IgM). We did not find any difference between patients and control subjects (healthy or polyneuropathic, some with IgM monoclonal paraprotein but without anti-MAG activity). The presence of autologous sera did not interfere with these results. We noted an increase in Leu 11+ cell percentages after pre-incubation of the patient cells with autologous sera but the phenotypes of cells from control subjects did not change after incubation with autologous or patient sera.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007694:Killer Cells, Natural / Q000145:classification* / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein