Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D006358:Hot Temperature; D006801:Humans; D013449:Sulfonamides / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D002147:Calmodulin; D013449:Sulfonamides; D001761:Bleomycin; C033772:N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide