Evaluation of potential nephrotoxicity of antibiotics.
In order to assess the potential nephrotoxcity excerted by various antibiotics in therapeutic doses, the effects of antibiotics administered to Wistar rats in vitro and in vivo were investigated in terms of protein synthesis, nucleic acid metabolism, and lysosome stability. In vivo experiment protein synthesis was inhibited by SM, KM, GM and CL. RNA metabolism and stability of lysosomal enzyme, acid-phosphatase, were also disturbed by the aminoglycosides. In vitro experiments yielded almost the same tendencies. In our studies cephalosporins and related antibiotics had no influence upon the metabolism of RNA, protein synthesis and lysosomal enzyme.
D000617:Aminoglycosides / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012313:RNA