[Decreased alpha fetoprotein in maternal serum in relation to increased alpha fetoprotein in amniotic fluid in a case of fetal trisomy 21 associated with esophageal atresia].
A subnormal maternal serum alpha-fetoprotein level associated with elevated alpha-fetoprotein level in amniotic fluid was found in a case of trisomy 21 combined with esophageal atresia in a fetus at 36 + 5 weeks of gestation. The significance of this observation is discussed in view of the possible biologic mechanisms resulting in maternal serum alpha-fetoprotein reduction in cases of fetal autosomal trisomies. The most likely hypotheses seem to be a reduced fetal alpha-fetoprotein production and/or an alteration of the placental regulation of the alpha-fetoprotein transfer from fetal to maternal blood via the placenta.
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D004933:Esophageal Atresia / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins
Erniedrigtes Alpha-Feto-protein im mütterlichen Serum in Verbindung mit erhöhtem Alpha-Feto-protein im Fruchtwasser in einem Fall einer fetalen Trisomie 21 in Assoziation mit einer Osophagusatresie.