[Hemorheologic, micro- and macrocirculatory effects of hypervolemic infusions of middle molecular weight hydroxyethyl starch (10%, 200,000/0.62) in healthy probands].
During an open clinical trial the influence of hypervolemic hemodilution (Infusion of 500 cc Elohäst within 1 h) on macrocirculation, microcirculation and blood fluidity of healthy volunteers was investigated. Blood pressure and heart rate remained constant during the infusion period and later on. The decline in hematocrit after 6 h was four points, plasma viscosity and erythrocyte aggregation, however, increased significantly. Three hours after completion of the infusion a significantly elevated blood flow in the common carotid artery could be assessed with a return to approximately normal values after 6 h. The improvement of the microcirculatory flow took a longer period of time. After 6 h a significantly increased erythrocyte velocity in the nailfold capillaries along with a significant augmentation of transcutaneously measured partial oxygen pressure could be stated.
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D008833:Microcirculation / Q000187:drug effects; D009262:Nails / Q000098:blood supply; D010865:Pilot Projects; D010974:Platelet Aggregation / Q000187:drug effects; D012212:Rheology; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch
Hämorheologische, mikro- und makrozirkulatorische Effekte einer hypervolämischen Infusion mittelmolekularer Hydroxyäthylstärke (10%, 200,000/0,62) bei Gesunden.