Effect of somatostatin on 45Ca fluxes in guinea-pig isolated atria.
The effect of somatostatin (SS, 10(-6) M and 5 X 10(-6) M) was studied on 45Ca fluxes in guinea-pig isolated atria. SS produced a dose-dependent decrease in 45Ca uptake, this effect being dependent on the stimulation rate and Ca concentration in the bathing media. The decrease in 45Ca uptake was more evident at faster (60 and 180 beats min-1) than at slower frequencies (15 beats min-1) and was less evident in high Ca (5.4 mM). SS had no effect on 45Ca efflux. These results suggest that SS inhibits the slow inward Ca current in guinea-pig atrial fibres.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*
D007473:Ion Channels; D013004:Somatostatin; D002118:Calcium