title: Chorea.
abstract: A variety of neurotransmitters have been implicated in the pathophysiology of chorea as exemplified by Huntington's chorea. These include dopamine, serotonin, acetylcholine, GABA and a variety of neuropeptides including substance P and somatostatin. Despite biochemical data that suggests that alterations in other neurotransmitters may be of greater significance, pharmacologic data still supports a major role of dopamine in the actual clinical manifestation of chorea.
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D002799:Cholinergic Fibers / Q000503:physiopathology; D002819:Chorea / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D003342:Corpus Striatum / Q000378:metabolism* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007980:Levodopa; D012110:Reserpine / Q000627:therapeutic use; D012701:Serotonin / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D012701:Serotonin; D013373:Substance P; D007980:Levodopa; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D012110:Reserpine; D004298:Dopamine