title: Infant development following the use of intravenous nutrition to women with persistently low urinary oestriol excretion.
abstract: During the 6-year period 1971 to 1976, 10,545 patients had urinary oestriol determinations during pregnancy and 333 (3.2%) had persistently low values. Of the 335 resultant infants 206 were from patients treated with intravenous dextrose and/or amino-acids (treated group) and 129 from nontreated patients (nontreated group). The stillbirth rate was 2.4% in the treated group and 11.6% in the untreated group (p greater than 0.001), and the neonatal death rates were 2.9% and 4.7% respectively (p = NS). Assessment of the surviving infants to 7 years of age revealed no significant differences in growth between treated and nontreated groups. There was no increase in the incidence of major neurological abnormalities in the treated infants (2.9%) when compared to those from nontreated pregnancies (1.3%) (p = NS), nor was there a significant difference in the incidence of minor neurological abnormality or findings on psychological assessments. We conclude that dextrose and/or amino-acid infusions given to pregnant women with low oestriol excretion reduced the perinatal mortality rate without significant compromise to subsequent development of surviving infants.
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use; D002658:Developmental Disabilities / Q000517:prevention & control*; D004964:Estriol / Q000652:urine*; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D005500:Follow-Up Studies; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D010288:Parenteral Nutrition; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D013997:Time Factors
chemical_list: D000596:Amino Acids; D004964:Estriol; D005947:Glucose