title: Peanut agglutinin inhibits proliferation of cultured breast cancer cells.
abstract: Cultured breast cancer cells express on their surface glycoproteins which are recognized by the peanut lectin (PNA). The proliferation of these cells (ZR-75.1 and 734-B) was inhibited by PNA. A mammary carcinoma cell line (BT-20) which does not react with PNA was not affected by this lectin. The combination of PNA with either retinoic acid or 4-hydroxy-tamoxifen led to an additive amplification of the antiproliferative activity. Also interferon-gamma showed in combination with PNA an improved growth-inhibitory action.
mesh_terms: D001212:Asialoglycoproteins; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D060748:Fetuins; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology*; D019887:Peanut Agglutinin; D013629:Tamoxifen / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000166:cytology*; D000509:alpha-Fetoproteins / Q000494:pharmacology
chemical_list: D001212:Asialoglycoproteins; D060748:Fetuins; D037102:Lectins; D019887:Peanut Agglutinin; D000509:alpha-Fetoproteins; C017029:asialofetuin; D013629:Tamoxifen; D014212:Tretinoin; D007371:Interferon-gamma