title: Haematological preclinical recording of adverse drug reactions--current status, problems, and needs. Part I: Standardization of experiments in relation to haematological examination.
abstract: The influences of sampling factors, such as age, health of laboratory animals, environmental conditions, and procedures on the standardization of haematological tests in safety drug evaluations performed on animals are discussed. Problems concerning formation and interpretation of haematology reference data are briefly analysed.
mesh_terms: D000367:Age Factors; D000818:Animals; D000830:Animals, Laboratory / Q000097:blood*; D001773:Blood Cells / Q000166:cytology; D001800:Blood Specimen Collection; D002940:Circadian Rhythm; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D004777:Environment; D006403:Hematologic Tests / Q000592:standards*; D008297:Male; D012016:Reference Values