title: "Spontaneous" complete remissions in chronic lymphocytic leukemia: report of three cases and review of the literature.
abstract: "Spontaneous" complete remissions (SCR) are a rare event in chronic lymphocytic leukemia (CLL). In this article, we report three cases of SCR observed in a series of 285 patients followed at a single institution during the last 15 years. SCR was documented by clinical and hematologic data, including bone marrow biopsy, and immune cell markers. A delay of 0.9-1.6 years between "clinical" and "clonal" remission was observed. A review of other cases of SCR in CLL is also performed.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000145:classification
chemical_list: D007372:Interferons