title: Intra-arterial prostacyclin compared to Praxilene in the management of severe lower limb ischaemia: a double blind trial.
abstract: The effectiveness of a 72 h. intra-arterial prostacyclin infusion has been compared to that of naftidrofuryl oxalate (Praxilene) in a double blind study of 29 patients with ischaemic rest pain in 30 legs. Long-term relief of symptoms was achieved in 14 legs (47%) and major limb amputation avoided in 18 (60%). No significant difference was demonstrated between the results of prostacyclin infusion and those of Praxilene.
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D011464:Epoprostenol / Q000008:administration & dosage*; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000008:administration & dosage*; D010166:Palliative Care; D011897:Random Allocation
chemical_list: D005663:Furans; D009257:Nafronyl; D011464:Epoprostenol