Follow-up of prospective randomized trial of ampicillin or chloramphenicol versus moxalactam treatment of Haemophilus influenzae type b meningitis.
In a prospective randomized trial, moxalactam administered to 66 children was compared with ampicillin or chloramphenicol given to 68 children for the treatment of Haemophilus influenzae type b meningitis. Acute morbidity and mortality rates were equivalent between the two treatment groups. At 2 years after discharge, the results of psychologic tests (Bayley Scales of Infant Development or McCarthy Scales of Children's Abilities) were also equivalent between the two treatment groups for patients remaining in the study.
D000667:Ampicillin / Q000627:therapeutic use*; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D002658:Developmental Disabilities / Q000209:etiology; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D008583:Meningitis, Haemophilus / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D009070:Moxalactam / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
D002701:Chloramphenicol; D000667:Ampicillin; D009070:Moxalactam