Effect of chlordecone and mirex on the acute hepatotoxicity of acetaminophen in mice.
1. Acetaminophen toxicity, as measured by leakage of intracellular enzymes, was increased by chlordecone and mirex with mirex having the greater effect. 2. These effects were confirmed by histological examination and by studies of enzyme leakage from isolated hepatocytes.
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D007631:Chlordecone / Q000494:pharmacology*; D004347:Drug Interactions; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008917:Mirex / Q000494:pharmacology*
D007306:Insecticides; D000082:Acetaminophen; D007631:Chlordecone; D008917:Mirex