Chronic T cell leukemia with a NK phenotype reacting with anti-myelin-associated glycoprotein (MAG) mouse monoclonal antibody.
We describe a patient demonstrating chronic T cell leukemia with a natural killer (NK) phenotype. The leukemic cells could be stained by OKT 3 (T cells), anti-Leu-7 and anti-myelin-associated glycoprotein (MAG) (NK cells) but not anti-Leu-11 monoclonal mouse antibody (activated NK cells). Fresh mononuclear cells showed a very low NK activity, although this activity returned to normal levels after 18 days incubation with interleukin-2 and some stimulants. It was not known why the NK activity of fresh mononuclear cells was low. This report is the first on leukemia characterized by anti-MAG monoclonal antibody.
D000911:Antibodies, Monoclonal; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010641:Phenotype; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein