Granulocyte factors as regulators of hemopoiesis. II. The mechanism of action and target cell for granulocyte factor activity.
Adherent granulocytes secrete a granulocyte factor (GF). This factor stimulates hemopoiesis in irradiated mice. The target cell for this hemopoiesis-regulating GF action is probably T lymphocyte. The results indicate that the target cell is hydrocortisone- and cyclophosphamide-sensitive and prove that granulocytes stimulate hemopoiesis in irradiated mice via secreted GF.
D000818:Animals; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains
D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors