The significance of activation of reticuloendothelial function on hepatectomy.
The prognosis of patients after massive hepatectomy is poor in certain cases whose hepatic reserve, including reticuloendothelial function, is deteriorated. We administered OK-432 before 70% hepatectomy on rats to activate the reticuloendothelial function and studied its effect on postoperative course. The elevations in plasma endotoxin, GOT and GTP were attenuated, and the deterioration of the complement activity after hepatectomy was greatly improved by OK-432 treatment. The RNA content in the liver was significantly increased by OK-432 administration. These findings suggest that activation of the reticuloendothelial function at the time of massive hepatectomy enhances endotoxin clearance from blood and thereby contributes in lessening the magnitude of hepatic injury, maintaining the serum complement, and improving liver protein synthesis.
D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D003165:Complement System Proteins / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004731:Endotoxins / Q000097:blood; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000502:physiology*; D010844:Picibanil / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D001688:Biological Products; D004731:Endotoxins; D010844:Picibanil; D012313:RNA; D003165:Complement System Proteins; D004247:DNA