[High-dose intravenous penicillin therapy in neurosyphilis: study of 62 cases. II. Evaluation of cerebrospinal fluid].
Sixty-two patients with symptomatic neurosyphilis were treated with 20 or 24 megaunits of intravenous penicillin G daily for 15 to 30 days. The mean follow-up time after the treatment was 30 months. Forty-one patients had pleocytosis in the CSF before treatment. Six months and twelve or more months later, abnormal cell count was observed in 4 (9.8%) and in 3 patients (7.3%), respectively. The CSF protein level and the titers of Wassermann reaction in the CSF decreased slowly after treatment. The gammaglobulin concentration of the CSF and the immunoglobulin production inside the blood-brain barrier were still increased beyond the first year after treatment. The results of the treatment of these patients with high doses of intravenous penicillin G were not different from the results verified with lesser doses of intramuscular penicillin that were reported in the literature.
D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D009494:Neurosyphilis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000032:analysis; D005719:gamma-Globulins / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D005719:gamma-Globulins; D010400:Penicillin G
Penicilinoterapia intravenosa em altas doses na neurossífilis: Estudo de 62 casos. II. Avaliação do líqüido cefalorraqueano.