[Effect of indomethacin on the development of cardiac and hemodynamic disorders in shock of immune origin].
Blockade of biosynthesis of prostaglandins (indomethacin) was shown to decrease significantly disorders of cardio- and hemodynamics after immune heart damages (intracoronary anticardiac serum injections) in experimental anesthetized dogs. A positive effect of indomethacin was produced by blockade of the first part (0-15 min) of capacity vessels dilation reaction (blood deposition), subsequent decrease of venous return limit and fall of heart output. Indomethacin potentiated constriction of coronary vessels.
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D007114:Immunization; D007213:Indomethacin / Q000627:therapeutic use*; D009206:Myocardium / Q000276:immunology; D011448:Prostaglandin Antagonists; D012769:Shock / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology
D011448:Prostaglandin Antagonists; D005719:gamma-Globulins; D007213:Indomethacin
Vliianie indometatsina na razvitie narusheniĭ kardio- i gemodinamiki pri shoke immunnogo geneza.