The role of neuropeptides in regulating airway function. Postsecretory metabolism of peptides.
Peptide hormones and neurotransmitters play an essential role in regulation of cellular metabolism. Once released from an endocrine cell or nerve ending, peptides encounter membrane-bound and soluble peptidases. The peptidases inactivate peptides or form fragments with novel biologic activity. Therefore, peptidases must play a major role in homeostatic control, but this aspect of regulation has been a neglected area. This review examines the postsecretory metabolism of biologically active peptides in the brain and alimentary tract, 2 organs in which peptide regulation is of crucial importance.
D001921:Brain / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism; D015260:Neprilysin; D009479:Neuropeptides / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000145:classification / Q000378:metabolism*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
D004745:Enkephalins; D005768:Gastrointestinal Hormones; D009479:Neuropeptides; D013373:Substance P; D010447:Peptide Hydrolases; D007703:Peptidyl-Dipeptidase A; D008666:Metalloendopeptidases; D015260:Neprilysin