Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.
Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D002460:Cell Line; D007274:Injections, Intraperitoneal; D007633:Keratins; D051379:Mice; D008819:Mice, Nude; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D016038:Skin Transplantation
D015127:9,10-Dimethyl-1,2-benzanthracene; D007633:Keratins