Effect of lindane on brain monoamine metabolism.
The effect of the oral administration of the organochlorinate pesticide Lindane (gamma-hexachlorociclohexane) in doses of 30, 60 and 120 mg/kg on the cerebral metabolism of 5-HT and catecholamines in female rats was studied 24 hr after the administration of the pesticide. All the doses tested caused a decrease in the concentration of cerebral and free serum tryptophan, with no significant change in the cerebral levels of 5-HT, although its rate of synthesis was inhibited at the lowest dose. The variations in the levels of 5-HIAA appears to be linked to its elimination from the brain. The higher doses cause increases in NA levels and turnover rates.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000097:blood / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D001556:Hexachlorocyclohexane; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine