Light microscopic evidence for a substance P-containing innervation of the human nucleus basalis of Meynert.
A two color histochemical/immunohistochemical method was used to demonstrate substance P and acetylcholinesterase in sections of the human nucleus basalis of Meynert (nbM). Substance P-immunoreactive terminal-like structures were found to make contact with magnocellular, acetylcholinesterase-positive perikarya and primary dendrites throughout all subdivisions of the nbM. This apparent innervation of nbM neurons was in most cases a relatively sparse one, but a small percentage of these neurons appeared to be recipients of a very heavy innervation which covered their perikarya and primary dendrites.
D000110:Acetylcholinesterase / Q000032:analysis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000032:analysis*; D002799:Cholinergic Fibers / Q000033:anatomy & histology / Q000201:enzymology; D005260:Female; D006801:Humans; D013373:Substance P / Q000032:analysis*; D013377:Substantia Innominata / Q000032:analysis* / Q000033:anatomy & histology / Q000201:enzymology
D013373:Substance P; D000110:Acetylcholinesterase