title: Plasma histamine levels in rats treated with trypanocidal diamidines.
abstract: The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene.
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D004133:Diminazene / Q000494:pharmacology; D006632:Histamine / Q000097:blood*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D010419:Pentamidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014344:Trypanocidal Agents / Q000494:pharmacology*
chemical_list: D000578:Amidines; D014344:Trypanocidal Agents; D010419:Pentamidine; D006632:Histamine; D004133:Diminazene