Biotransformation of 1-nitropyrene and 2-nitrofluorene to novel metabolites, the corresponding formylamino compounds, in animal bodies.
The present study provides the first evidence that nitropolycyclic aromatic hydrocarbons such as 1-nitropyrene and 2-nitrofluorene are metabolized to the corresponding formylamino compounds in animal bodies. The study shows that the formation of such novel metabolites, 1-formylaminopyrene and 2-formylaminofluorene, is due to N-formylation of the nitroreduction products, 1-aminopyrene and 2-aminofluorene, by liver formamidase in the presence of N-formyl-L-kynurenine.
D000818:Animals; D005558:Arylformamidase / Q000502:physiology; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism; D005449:Fluorenes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D011721:Pyrenes / Q000378:metabolism*; D011817:Rabbits; D051381:Rats
D002273:Carcinogens; D005449:Fluorenes; D011721:Pyrenes; C049354:N-formyl-1-aminopyrene; C019499:2-nitrofluorene; D005558:Arylformamidase; C032668:1-nitropyrene