Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.
Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.
D000818:Animals; D007611:Aprotinin / Q000097:blood* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003174:Complement C1 Inactivator Proteins / Q000097:blood* / Q000494:pharmacology; D016264:Dextran Sulfate; D003911:Dextrans / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007704:Kininogens / Q000097:blood; D011288:Prekallikrein / Q000097:blood; D013552:Swine
D003174:Complement C1 Inactivator Proteins; D003911:Dextrans; D007704:Kininogens; D016264:Dextran Sulfate; D011288:Prekallikrein; D007611:Aprotinin