Beta 1/beta 2-splitting of bisoprolol.
In an open study with 16 angina pectoris patients with concomitant chronic obstructive bronchitis, the effect of single oral doses of the beta-adrenoceptor antagonist bisoprolol (5, 10, 15, 20, 30, and 40 mg) on blood pressure (BP), heart rate (HR), airway resistance (AWR), and forced expiratory volume in 1 s (FEV1) was investigated. In the dose range between 5 and 20 mg, no increase in AWR and no decrease in FEV1 was observed. Thirty and 40 mg of bisoprolol produced an increase in AWR and a decrease in FEV1. A reduction in BP and HR was observed even after the lowest bisoprolol dose.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D017298:Bisoprolol; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D017298:Bisoprolol