Airway hyper-reactivity and eosinophilia in rats treated with Sephadex particles.
The intravenous injection of Sephadex particles (G200) into rats produced a specific increase in numbers of blood eosinophils, peaking 7 days later. A second injection, given on day 14 when the numbers of blood eosinophils had fallen to control levels, produced a dose-dependent increase in numbers, greater than the first, and peaking 5 days later. At this time, there was a dose-dependent increase in numbers of eosinophils, but not of other leucocytes, in broncho-alveolar lavage fluids and lung tissue, together with an increase in sensitivity of the rats to the respiratory effects produced by the intravenous injection of 5-hydroxytryptamine.
D000818:Animals; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000139:chemically induced*; D003911:Dextrans / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced*; D007958:Leukocyte Count; D010316:Particle Size; D051381:Rats; D012701:Serotonin
D003911:Dextrans; D012701:Serotonin; C025614:sephadex