Increased interhemispheric coupling of the dopamine systems induced by prenatal stress.
Maternal noise and light stress, randomly applied throughout pregnancy, has previously been shown to induce alterations in behavioral asymmetries in the adult offspring. In the present study, we investigated whether interhemispheric communication of neurotransmitters would be influenced by this treatment. Dopamine and serotonin turnover rates were measured in the left and right prefrontal cortex, nucleus accumbens and caudate nucleus of adult rats which were stressed prenatally. In control animals, dopamine turnover was only significantly correlated between the left and right hemispheres in the males (p less than 0.01). Prenatal stress greatly increased the degree of interhemispheric correlation (p less than 0.001) which now became highly significant in both sexes (p less than 0.001). For serotonin, left-right turnover rates only correlated in control females and no effect of gestational stress was seen. These results indicate that prenatal stress greatly increases interhemispheric coupling of dopamine in the adult offspring. We suggest that this facilitated communication may underly the alterations in behavioral asymmetries induced by prenatal stress.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological / Q000503:physiopathology*
D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine