title: [Diagnostic and therapeutic approach to lung neoplasms. Departmental experience at the Mestre Hospital].
abstract: The results are reported of a multidisciplinary diagnostic and therapeutic program applied to 381 patients with lung carcinoma from 1983 through 1985 at Mestre General Hospital. Cytologic and/or histologic diagnosis was established in 95% and staging accomplished in 96% of the patients. One-hundred-twenty-nine patients with non-small cell cancer were primarily treated by surgery (lobectomy or pneumonectomy); 3-year survival of this group was 48%. Of the 45 patients with pN1 or pN2 disease, 23 were treated with postoperative adjunctive mediastinal radiotherapy (50Gy/25 F/5Wk); however, survival showed no significant difference in the two groups. Ninety-seven inoperable patients were treated by radiotherapy alone; among those receiving doses of 50-60 Gy in 5 to 6 weeks, 3-year survival was 10%. Chemotherapy (CAMP), used in 23 cases (22 stage IV, 1 stage III), showed no improvement in survival, as compared with a similar series of patients submitted to symptomatic treatment alone. Of the 27 patients affected by small-cell carcinoma, 14 were treated with an aggressive radiochemotherapy protocol and 13 with palliative radiotherapy or low-dose chemotherapy: median survival in the two groups was respectively 45 and 60 weeks. Our study demonstrates the clinical feasibility of interdisciplinary programs routinely applied to a large population of lung cancer patients, and confirms its rationale in terms of early diagnosis, improved staging, and adequate treatment.
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy*; D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care
vernacular_title: L'approccio diagnostico e terapeutico alle neoplasie polmonari. Esperienza dipartimentale dell'Ospedale di Mestre.