Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer.
The circulating levels of placental protein 12 (PP12), a somatomedin-binding protein, were measured by radioimmunoassay in 37 postmenopausal women with ovarian tumors. Elevated levels (above 47 micrograms/l) were observed in 16 of 25 patients (64%) with malignant and 2 of 12 patients (17%) with benign tumors. Elevated levels were more frequent and higher in patients with advanced disease. Within 1 week of surgery, the levels fell in 13 of 17 cases (77%). In addition to clinical interest, these results contribute to our knowledge of carrier proteins of growth factors in patients bearing malignant ovarian neoplasms.
D000368:Aged; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000601:surgery; D011257:Pregnancy Proteins / Q000097:blood*; D011863:Radioimmunoassay; D013002:Somatomedins / Q000378:metabolism*
D002352:Carrier Proteins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011257:Pregnancy Proteins; D013002:Somatomedins