title: Intracranial embryonal carcinoma and precocious puberty.
abstract: A boy aged 7.5 years presented with precocious onset of secondary sexual characteristics and symptoms and signs of neurological dysfunction. A CT brain scan demonstrated a suprasellar mass lesion. The elevated beta-hCG and alpha-fetoprotein concentrations in cerebrospinal fluid and in serum were consistent with a diagnosis of intracranial embryonal carcinoma, although histological diagnosis was not available. The tumour markers beta-hCG and alpha-FP should be looked for in all children with precocious puberty presenting with midline brain tumours.
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000150:complications*; D002648:Child; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology*; D011859:Radiography; D013724:Teratoma / Q000150:complications*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins