[Biochemical bases of the antifertility action of the nonsteroidal antiandrogen niphtolid].
The study was made of biosynthesis and levels of nucleic acids and proteins in the head of epididymis as well as of the fertility of intact mature male rats under antiandrogenic exposure to nonsteroid antiandrogenic compound niphtolid. Niphtolid given per os in a dose of 25 micrograms/kg during 8 or 30 days decreased the mass of the organ and its concentrations of DNA, RNA and proteins. The above mentioned alterations seemed to be caused by inhibited inclusion of labeled precursors into biopolymers. A long-term intake of antiandrogen (10 micrograms/kg of body mass daily for a six-months period) was followed by developing transient infertility. The possibility to use niphtolid-like compounds both alone and in combination with antigonadotrophic drugs for fertility regulation is assumed.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism; D005298:Fertility / Q000187:drug effects*; D005485:Flutamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013997:Time Factors
D000813:Anilides; D012313:RNA; D005485:Flutamide; D004247:DNA
Biokhimicheskie osnovy antifertil'nogo deĭstviia nesteroidnogo antiandrogena niftolida.