[Enzyme induction and anticonvulsants].
Serum gamma-GT-activity was significantly (0.01 greater than P greater than 0.001) elevated in 18 of 30 epileptics receiving carbamazepine (CBZ), i.e. in 60%. The incidence of abnormal gamma-GT-levels in the control group (25 neurotic patients taking minor tranquilizers) was lower (12%). The possible relationships between the enzyme induction or chronic hepatic toxicity and the elevation of serum gamma-GT-activity in epileptics taking CBZ are discussed.
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004790:Enzyme Induction / Q000187:drug effects; D004798:Enzymes / Q000097:blood*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood
D004798:Enzymes; D002220:Carbamazepine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
Enzyminduktion und Antiepileptika.