[Cancerogenic effect of long-term benzene exposure. Occurrence at the same work place of a plasmacytoma and two solid carcinomas ].
A report is given on three different malignomas appearing after high inhalative exposure to benzene for many years at the same working place in a cable plant. The exposure to benzene amounted to 22 years in a 50 year old man with oesophagus carcinoma, 17 years in a 61 year old man with plasmocytoma and 10 years in a 45 year old man with embryonal carcinoma of the testicles. The malignomas appeared 5-7 years after the end of the exposure. The carcinogenity of benzene is discussed on the basis of a survey of medical literature on epidemiological studies, casuistic contributions and experimental investigations in animals. A direct and indirect mechanism of benzene inducing carcinogenity is discussed: Activation of normal cellular oncogenes in DNA molecules by changes directly caused by benzene and; Damage of the lymphatic cell particularly susceptible to benzene followed by a disturbance of immunological monitoring and defence reactions against tumour cells.
D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001554:Benzene / Q000009:adverse effects*; D004781:Environmental Exposure; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000139:chemically induced*; D012189:Retrospective Studies; D013724:Teratoma / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000139:chemically induced*
D000395:Air Pollutants, Occupational; D001554:Benzene
Zur kanzerogenen Wirkung langjähriger Benzenexposition. Aufreten eines Plasmozytoms und zweier solider Malignome an ein und demselben Arbeitsplatz.