The inflammation mediators interleukin 1 and hepatocyte-stimulating factor are differently regulated in human monocytes.
Human peripheral monocytes can be induced by bacterial lipopolysaccharide to produce the inflammatory mediators interleukin 1 (IL 1) and hepatocyte-stimulating (HS) activity. IL1 and HS activities were separated by gel permeation chromatography. It is also shown that the two monokines are differently regulated. Evidence for this stems from the finding that monocytes cultured for 24 h lose their ability to produce IL1 in response to lipopolysaccharide, while synthesis of HS activity remains essentially unaffected.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D015850:Interleukin-6; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D009000:Monocytes / Q000502:physiology*; D015846:Monokines; D014176:Protein Biosynthesis; D013997:Time Factors; D000515:alpha 1-Antitrypsin / Q000096:biosynthesis; D000511:alpha-Macroglobulins / Q000096:biosynthesis
D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides; D015846:Monokines; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins