Effects of plasma hyperviscosity on skeletal muscle blood flow and blood viscosity in vivo.
The effect of plasma hyperviscosity on skeletal muscle blood flow and blood viscosity in vivo was studied. Blood flow and viscosity in vivo were determined in the isolated and vasodilated calf muscle of one hind limb in dogs. Plasma hyperviscosity was induced by suspending red blood cells in concentrated and isotonic solutions of low molecular weight dextran in saline. Viscosity in vivo was determined by comparing pressure-flow relationships for blood and a reference solution. Blood viscosity in vitro was determined in a Wells-Brookfield cone-plate viscometer. Determinations were made for plasma viscosities of 1.3, 2.2 and 4 cP. It was found that blood flow and viscosity in vivo were strongly dependent on plasma viscosity and that the effects in vivo could be predicted from values obtained in vitro.
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D009132:Muscles / Q000098:blood supply*; D010949:Plasma / Q000502:physiology*
D003911:Dextrans