[Interferon-producing and cytotoxic activity of natural killer cells in multiple sclerosis patients].
Examination of 22 patients with multiple sclerosis (MS) has revealed a decrease in the cytotoxic activity of natural killer cells (NKC), in the production of endogenic interferon (EI) in the system of NK--target cells, and in the production of alpha- and gamma-interferon by stimulated lymphocytes. Some patients showed dissociation of the cytotoxic and interferon-producing activity of NKCs. Possible mechanisms responsible for changes in NKC activity are discussed. The authors have concluded that disturbances in the NKC-EI system are manifestations of the total regulatory imbalance in the immune system.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D007372:Interferons / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons
Interferonprodutsiruiushchaia i tsitotoksicheskaia aktivnost' estestvennykh kletok-killerov u bol'nykh rasseiannym sklerozom.