A pH-dependent dissociation of poliovirus procapsids.
At pH 7.6-8.2, poliovirus procapsids are dissociated in the cold to 14 S subunits which exhibit the same antigenicity and ability to be reassembled to empty capsids as naturally occurring 14 S subunits. The dissociation of the procapsids at pH 8.2 follows exponential kinetics. At pH 8.4 or 8.5, the procapsids are converted to 80 S H-antigenic, empty capsids.
D002213:Capsid / Q000378:metabolism*; D000939:Epitopes / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046911:Macromolecular Substances; D017955:Poliovirus / Q000378:metabolism*
D000939:Epitopes; D046911:Macromolecular Substances