Synthesis of placental proteins by the human placenta perfused in vitro. Preliminary report.
Fresh human placental tissue from deliveries at term was perfused in closed circulation on both the maternal and fetal side. At given times during the 4-hour perfusion period, the amount of human chorionic gonadotropin, human placental lactogen, pregnancy-specific beta 1-glycoprotein and pregnancy-associated plasma protein A was determined in the perfusing buffer. These placental proteins were also quantified in the placental tissue before and after perfusion. Calculations showed that all placentae (n = 3) were able to synthesize all 4 proteins tested.
D006063:Chorionic Gonadotropin / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D010926:Placental Hormones / Q000096:biosynthesis*; D010928:Placental Lactogen / Q000096:biosynthesis; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000096:biosynthesis; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000096:biosynthesis
D006063:Chorionic Gonadotropin; D010926:Placental Hormones; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen; D011266:Pregnancy-Associated Plasma Protein-A