[Determination of maternal serum alpha fetoprotein with a Polish AFP radioimmunoassay--a suitable screening method for neural tube defects?].
230 double determinations of maternal serum-alpha-fetoprotein have been made using a Polish AFP-RIA. On this basis the applicability of this method as a screening for neural tube defects has been proved. An additional comparison with a French RIA and an enzymimmunoassay (EIA) from the Serum-Werke Dessau confirmed an equal accuracy. There were three pathological increased values of AFP. In one case an anencephalus was found and in the other a spina bifida. In the third case the value was normal at the control examination. A general AFP screening in all pregnant women is recommended.
D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000097:blood / Q000175:diagnosis*; D011044:Poland; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D011863:Radioimmunoassay / Q000379:methods*; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins
Bestimmung des mütterlichen Serum-alpha-Fetoproteins (AFP) mit einem polnischen AFP-Radioimmunoassay--eine geeignete Screening-Methode zur Erkennung von Neuralrohrdefekten?