title: [Oral contrast media for magnetic resonance tomography of the abdomen. 1. Comparative animal studies of positive and negative contrast media].
abstract: Beagle dogs were investigated by MRI (Siemens Magnetom, 0.35 T) after oral administration of aqueous solutions of Gd-DTPA (n = 4), ferric ammonium citrate (n = 1), and magnetite dextran (n = 2). High signal intensity of the GI-tract versus adjacent structures was obtained with Gd-DTPA and ferric ammonium citrate. Magnetite showed negative contrast versus adjacent structures. However, magnetite displayed lower contrast relative to liver, muscle and gut wall compared to Gd-DTPA and ferric ammonium citrate. In relatively T2-weighted sequences labeling of poorly filled bowel loops was significantly better with Gd-DTPA and ferric ammonium citrate. For GI-tract contrast enhancement we conclude that positive contrast media are of higher diagnostic value compared to negative contrast agents.
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology*; D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D004285:Dogs; D005260:Female; D005290:Ferric Compounds; D005682:Gadolinium; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D000644:Quaternary Ammonium Compounds; D014867:Water
chemical_list: D003287:Contrast Media; D003911:Dextrans; D005290:Ferric Compounds; D009942:Organometallic Compounds; D000644:Quaternary Ammonium Compounds; D014867:Water; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; C013531:ferric ammonium citrate
vernacular_title: Orale Kontrastmittel für die magnetische Resonanztomographie des Abdomens. Teil 1: Tierexperimenteller Vergleich positiver und negativer Kontrastmittel.