Effect of FK506 in experimental organ transplantation.
FK506 is the most potent immunosuppressive agent known. Its toxicity is substantial in dogs, minor in rats, and unknown in subhuman primates. In small doses that are nontoxic even in dogs, it can be used in synergistic combination with cyclosporine, steroids, and presumably in other drugs.
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000627:therapeutic use* / Q000633:toxicity; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011241:Prednisone / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D011912:Rats, Inbred ACI / Q000276:immunology; D011914:Rats, Inbred BN / Q000276:immunology; D011917:Rats, Inbred Lew / Q000276:immunology; D016559:Tacrolimus; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011725:Pyridines; D011241:Prednisone; D016559:Tacrolimus