[Phenthiuram induction of micronuclei in mammalian somatic cells].
Genotoxic effects of the preparative-form phenthiuram on the induction of micronuclei in cultured Chinese hamster V-79 cells and polychromatic erythrocytes of mouse bone marrow have been studied. The phenthiuram induced cytogenetic effects in cultured somatic cells without metabolic activation being only in toxic concentrations. Similar effects were observed in polychromatic erythrocytes after treatment with subtoxic concentrations.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects*; D002478:Cells, Cultured; D002733:Chlorophenols; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009154:Mutation; D010575:Pesticides / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*; D013893:Thiram / Q000494:pharmacology*
D002733:Chlorophenols; D010575:Pesticides; D010636:Phenols; D013859:Thiocarbamates; D013893:Thiram; D001556:Hexachlorocyclohexane; C013993:fentiuram
Induktsiia fentiuramom mikroiader v somaticheskikh kletkakh mlekopitaiushchikh.