title: Beta-subunit of baboon chorionic gonadotropin. Continuous flow Fmoc-polyamide synthesis of the C-terminal 37-peptide.
abstract: The synthesis of a 37-peptide fragment derived from the carboxyl terminal of the beta-subunit of baboon chorionic gonadotropin has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of N alpha-fluorenylmethoxy-carbonyl-glutamine with its sidechain protected by the 4,4'-dimethoxybenzhydryl group enabled successful incorporation of this residue onto a hydroxymethyl linkage agent without apparent side reaction.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006063:Chorionic Gonadotropin / Q000138:chemical synthesis*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002851:Chromatography, High Pressure Liquid; D005449:Fluorenes; D005973:Glutamine / Q000031:analogs & derivatives; D010215:Papio; D010446:Peptide Fragments / Q000138:chemical synthesis*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005449:Fluorenes; D010446:Peptide Fragments; D005973:Glutamine; C055798:N(alpha)-fluorenylmethoxycarbonylglutamine