Interferon enhances the natural killer cell activity of the retinoblastoma patients to autologous retinoblastoma cells.
The cytotoxic activities of the peripheral lymphocytes prepared from two retinoblastoma patients to freshly isolated autologous tumor cells were measured using 51Cr-release assay. The retinoblastoma cells of the two patients resisted lysis by unstimulated effectors, whereas interferon(IFN)-stimulated effector cells gave a significantly higher cytotoxicity. This result implies that IFN therapy may be potent in treating high-risk retinoblastoma patients.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005134:Eye Neoplasms / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D012175:Retinoblastoma / Q000276:immunology*
D007372:Interferons