[Animal experiments to determine the toxicity of mercury(II)-chloride in hemostasis].
In the course of an experimental poisoning of rats with mercury(II)-chloride no disturbances of haemostasis occurred, from which the development of a consumption coagulopathy might be concluded. Only a diminution of the plasminogen level could be found which is due to a moderate damage of liver parenchyme. The increased activity of the free form of the plasminogen activator found in the kidney homogenate is considered as an enzymatic activation because of kidney cell necrosis.
D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D008631:Mercury Radioisotopes; D010960:Plasminogen Activators / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008631:Mercury Radioisotopes; D008627:Mercuric Chloride; D010960:Plasminogen Activators
Tierexperimentelle Untersuchungen zur toxischen Beeinflussung der Hämostase durch Quecksilber(II)-chlorid.