[Effect of antibodies to S-100 group proteins on the electrical activity and chemical sensitivity of the cerebral cortical neurons].
The influence of antibodies to proteins S-100 group on electrical activity and chemical sensitivity of rabbit cortical neurons has been investigated by means of extracellular recording and microiontophoresis. It has been found that anti-S-100 increase as a rule spontaneous discharge rate of the neurons, decrease, blockade or invert the neuronal responses to acetylcholine, noradrenaline and glutamate action. It is supposed that proteins S-100 group take part in regulation of eleitrogenic and postsynaptic (primarily glutamate- and GABA-ergic) processes of neural and glial cells in the brain.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology; D007114:Immunization; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D009418:S100 Proteins / Q000276:immunology*; D005719:gamma-Globulins / Q000494:pharmacology
D000906:Antibodies; D005971:Glutamates; D009418:S100 Proteins; D005719:gamma-Globulins; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie antitel k belkam gruppy S-100 na élektricheskuiu aktivnost' i khimicheskuiu chuvstvitel'nost' neĭronov kory mozga.