Rat peritoneal mast cells release dipeptidyl peptidase II.
Purified rat peritoneal mast cells have a 10-20-fold higher dipeptidyl peptidase II (DPP II) activity as compared with that of macrophages from the same source. Upon stimulation with the secretagogue Compound 48/80, DPP II is released from peritoneal-lavage cells and from purified mast cells, but not from purified macrophages, in a dose-dependent manner. Maximally, about one-third of the DPP II present in peritoneal-lavage cells is released. Substance P and the antigen/IgE system probably produce a similar effect. Both histamine and Zn2+, two ingredients of mast-cell granules, strongly inhibit DPP II at concentrations reported to occur in the granules. A possible role of mast-cell DPP II in the remodelling of connective tissue is discussed.
D000818:Animals; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D008264:Macrophages / Q000201:enzymology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000201:enzymology*; D010047:Ovalbumin / Q000494:pharmacology; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D013373:Substance P / Q000494:pharmacology; D007507:Therapeutic Irrigation; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D006633:Histamine Antagonists; D013373:Substance P; D003189:p-Methoxy-N-methylphenethylamine; D010047:Ovalbumin; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C100151:dipeptidyl peptidase II