Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer.
Bleomycin has become an important component of combination chemotherapy, particularly in the treatment of metastatic testis carcinoma. Pulmonary toxicity is a major risk and irreversible pulmonary fibrosis or even death may result from its use. Rarely diffuse fibrosis may lead to discrete nodularity mimicking pulmonary metastasis. We report such a case, and discuss the various clinical, radiographic and histopathological forms of bleomycin-induced pulmonary toxicity.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D013724:Teratoma / Q000556:secondary* / Q000628:therapy; D013736:Testicular Neoplasms / Q000473:pathology* / Q000628:therapy
D001761:Bleomycin