Systemic anaphylaxis in mast-cell-deficient mice of W/Wv and Sl/Sld genotypes.
Active systemic anaphylaxis was induced in mast-cell-deficient mice of W/Wv and Sl/Sld genotypes. The mast-cell-deficient mice were successfully sensitized either by an intraperitoneal injection of chicken gamma-globulin (C gamma G) mixed with adjuvant, alum and saline extract of Bordetella pertussis, or by an intravenous injection of C gamma G alone. Sensitized mice showed signs of systemic anaphylaxis and died after one or more intravenous challenge injections of C gamma G. These studies show that active systemic anaphylaxis can occur in mast-cell-deficient mice and suggest that cells other than mast cells may release adequate mediators to support systemic anaphylaxis.
D000707:Anaphylaxis / Q000209:etiology*; D000818:Animals; D005838:Genotype; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D005719:gamma-Globulins / Q000276:immunology
D005719:gamma-Globulins; D007073:Immunoglobulin E