The correlation between sensory-efferent functions mediated by the capsaicin-sensitive neurons and substance P content of the rat urinary bladder.
The substance P-like immunoreactivity (SP-LI) of the urinary bladder of adult rats was depleted by capsaicin desensitization (50 mg/kg, s.c., 4 days before) or extrinsic denervation (pelvic ganglionectomy) thus indicating its neurogenic sensory origin. SP-LI levels were inversely proportional to the volume threshold for micturition but not to the amplitude of micturition contraction. Moreover SP-LI levels were directly related to the amplitude of the capsaicin- but not field stimulation-induced contraction of the rat isolated bladder. These findings indicate that the SP-LI level of the rat bladder is a useful index for monitoring the dual sensory-efferent functions of the capsaicin-sensitive innervation of this organ.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D003714:Denervation; D004558:Electric Stimulation; D005725:Ganglia, Autonomic / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009475:Neurons, Afferent / Q000378:metabolism; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*
D013373:Substance P; D002211:Capsaicin