Reversing the detrimental effect of adriamycin on skin grafts in rats.
We evaluated in a rat model the effects of a homologous fibrin glue in reversing the effects of Adriamycin on adherence and take of skin grafts. A total of 40 male Fisher rats were used in the study. During the first phase of the experiment, the animals were assigned to either group I (N = 10) receiving normal saline or group II (N = 10) receiving 6 mg/kg Adriamycin by tail vein injection 24 hours before surgery. Skin grafts with and without fibrin glue were placed over wounds in the backs of the animals and adherence was measured at 24 and 48 hours. In the second phase (N = 20), the experiment was repeated, this time evaluating the total area of skin graft take at 7 days. Fibrin glue was found to increase adherence and take of skin grafts in all Adriamycin-treated animals.
D000818:Animals; D007611:Aprotinin; D004317:Doxorubicin / Q000633:toxicity*; D004338:Drug Combinations; D005176:Factor XIII; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D016038:Skin Transplantation; D013917:Thrombin
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D004317:Doxorubicin; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin