Some aspects of a non-linear effect of zinc ions on the histamine release from rat peritoneal mast cells.
Addition of zinc-chloride or zinc-orotate to the lavage medium successfully influences the histamine release from rat peritoneal mast cells. The effect of these zinc compounds is not doses-linear. 20 and 30 mg/l ZnCl2 cause a rather strong, 0.5, 5 and 10 mg/l ZnCl2 a weak depression in the release of histamine. An increase in the histamine release is caused by 40 mg/l ZnCl2. A similar, likewise non-doses-linear effect, can be observed with zinc-orotate. Concentrations of 10 and 30 mg/l zinc-orotate cause a decrease of the release; 0.05, 0.1, 1 and 60 mg/l have only minimal effects; an addition of 90 mg/l leads to an increase in the histamine release. Related to the Zn2+ ion the effect of zinc-chloride and zinc-orotate is not equivalent.
D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000494:pharmacology*; D017967:Zinc Compounds
D002712:Chlorides; D017967:Zinc Compounds; D009963:Orotic Acid; C016837:zinc chloride; D015032:Zinc