Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats.
Using an experimental model of global ischemia of the brain in rats, we have shown that a Ca2+ antagonist nicardipine attenuates, and a Ca2+ agonist YC-170 accelerates, the liberation of free fatty acids in the ischemic whole brain. The effects of YC-170 were negated by the previous administration of an adequate dose of nicardipine. This is the first report on the action of a Ca2+ agonist on the metabolism of the brain, and the results seem to provide supportive evidence for the role of Ca2+ in ischemic injury of the brain.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D009529:Nicardipine / Q000494:pharmacology*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009829:Oleic Acids / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013229:Stearic Acids / Q000378:metabolism
D001095:Arachidonic Acids; D005230:Fatty Acids, Nonesterified; D007473:Ion Channels; D009829:Oleic Acids; D010169:Palmitic Acids; D013229:Stearic Acids; C046721:YC 170; D009529:Nicardipine; D009543:Nifedipine