Absence of HLA class I and class II antigens as well as beta 2-microglobulin from normal and pathological human spermatozoa.
Human spermatozoa from 87 donors with normal or pathologic semen specimen were examined for the expression of HLA-class I and class II antigens as well as beta 2-microglobulin (beta 2m) using a panel of monoclonal antibodies in an indirect immunofluorescence test. The results make it very unlikely that HLA-class I and class II molecules as well as beta 2m are expressed on human sperm cells.
D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis* / Q000145:classification / Q000276:immunology; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000276:immunology; D013094:Spermatozoa / Q000002:abnormalities / Q000032:analysis / Q000276:immunology* / Q000503:physiopathology; D001613:beta 2-Microglobulin / Q000032:analysis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D001613:beta 2-Microglobulin