Diagnostic value of the determination of an interferon-induced enzyme activity: decreased 2',5'-oligoadenylate dependent binding protein activity in AIDS patient lymphocytes.
The 2, 5'-oligoadenylate dependent binding protein activity was measured in peripheral blood lymphocyte extracts of AIDS and pre-AIDS and compared to healthy heterosexual controls. The binding activity in lymphocytes from AIDS (mean, 0.71 fmole/10(6) cells) and pre-AIDS (mean, 0.66 fmole/10(6) cells) was approximately 65% lower than that found in controls (mean, 2.41 fmole/10(6) cells) suggesting that this enzymatic activity may be a useful biochemical marker for the diagnosis of AIDS.
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000201:enzymology; D004722:Endoribonucleases / Q000032:analysis*; D004790:Enzyme Induction; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000201:enzymology*
D007372:Interferons; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease