Efficacy of antibody NF2F11 staining in the investigation of severe long-standing constipation. A preliminary report.
A retrospective study of 7 adult patients (6 with severe, long-standing constipation and 1 with chronic idiopathic intestinal pseudoobstruction) was carried out to test the diagnostic potential of the antineurofilament monoclonal antibody NF2F11. In 4 of the cases of constipation and in the 1 case of pseudoobstruction, paraffin sections of resected colon revealed an anomaly in that the axon bundles of both plexus systems remained unstained. This picture differed from that found in the control population. The results are discussed in relation to previous studies of congenital neurogenic abnormalities of the digestive tract in children.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001369:Axons / Q000648:ultrastructure; D003106:Colon / Q000294:innervation* / Q000648:ultrastructure; D003248:Constipation / Q000151:congenital* / Q000473:pathology; D005260:Female; D006801:Humans; D007382:Intermediate Filaments / Q000276:immunology; D007415:Intestinal Obstruction / Q000151:congenital* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal