Nucleotide-sensitive ion channels in human insulin producing tumour cells.
Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated non-selective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the "maxi" calcium-activated potassium channel is present in these cells.
D000236:Adenoma / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000502:physiology; D000328:Adult; D000818:Animals; D002118:Calcium / Q000502:physiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007473:Ion Channels / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats
D007328:Insulin; D007473:Ion Channels; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D011188:Potassium; D002118:Calcium