title: Interferon enhances the natural killer cell activity of the retinoblastoma patients to autologous retinoblastoma cells.
abstract: The cytotoxic activities of the peripheral lymphocytes prepared from two retinoblastoma patients to freshly isolated autologous tumor cells were measured using 51Cr-release assay. The retinoblastoma cells of the two patients resisted lysis by unstimulated effectors, whereas interferon(IFN)-stimulated effector cells gave a significantly higher cytotoxicity. This result implies that IFN therapy may be potent in treating high-risk retinoblastoma patients.
mesh_terms: D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005134:Eye Neoplasms / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D012175:Retinoblastoma / Q000276:immunology*
chemical_list: D007372:Interferons