title: Roles of opioid peptides of PAG in analogous electro-acupuncture inhibition of experimental arrhythmia: analyzed by specific antisera microinjection.
abstract: Using specific antisera microinjected into periaqueductal grey (PAG), we further studied the mechanism of the analogous electroacupuncture, deep peroneal nerve stimulation (DPNS), inhibition on the experimental arrhythmia, hypothalamic stimulation-induced ventricular extrasystoles (HVE). Neither normal serum nor anti-leu-enkephalin antiserum interfered with DPNS inhibition; anti-dynorphin A (1-8) tended to attenuate the inhibition; and anti-beta-endorphin antiserum blocked it. The results provided further evidence for the hypothesis that beta-endorphin in PAG plays an important role in the neural circuit of DPNS inhibition on HVE.
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D004558:Electric Stimulation; D004723:Endorphins / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D010487:Periaqueductal Gray / Q000187:drug effects / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000187:drug effects / Q000502:physiology; D011817:Rabbits
chemical_list: D004723:Endorphins; D007106:Immune Sera