Chemical and biological properties of pentaammineruthenium-bleomycin complexes.
The reaction of [(H2O)(NH3)5RuII]2+ with bleomycin forms at least two stable products following oxidation to the Ru(III) analog. Spectroscopic and electrochemical measurements indicate monodentate binding of [(NH3)5RuIII] to the imidazole and pyrimidine moieties, with coordination to the latter involving the exocyclic amine nitrogen. DNA cleavage studies show the complexes to be ineffective in DNA strand scission. In vitro biological studies reveal these adducts to be cytotoxic.
D000818:Animals; D001761:Bleomycin / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity / Q000031:analogs & derivatives; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009942:Organometallic Compounds; D012428:Ruthenium / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship
D009942:Organometallic Compounds; C050432:pentaammineruthenium(III)-bleomycin complex; D001761:Bleomycin; D012428:Ruthenium; D004247:DNA