Human plasma lipofuscin melanins formed from tryptophan metabolites.
Incubation of human plasma with the tryptophan metabolites 3-hydroxy-DL-kynurenine (3HK) or 3-hydroxyanthranilic acid (3HAA) yields soluble brown pigments with the fluorescence spectrophotometric and paper chromatographic properties of plasma lipofuscin (PL). An alternative to the recognized tyrosine pathway of melanogenesis is therefore demonstrated in human plasma.
D015095:3-Hydroxyanthranilic Acid / Q000378:metabolism*; D000328:Adult; D002854:Chromatography, Paper; D006801:Humans; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000378:metabolism; D008062:Lipofuscin / Q000097:blood*; D008297:Male; D008543:Melanins / Q000302:isolation & purification; D008875:Middle Aged; D010860:Pigments, Biological / Q000097:blood*; D013050:Spectrometry, Fluorescence; D062367:ortho-Aminobenzoates / Q000378:metabolism*
D008062:Lipofuscin; D008543:Melanins; D010860:Pigments, Biological; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; C005045:3-hydroxykynurenine; D007737:Kynurenine