[Mechanism of the interaction of the individual components of levorin and nystatin preparations with lipid membranes].
Mechanism of interaction between separate levorin and nystatin component and lipid membranes was studied. It was shown that components A0, A1, A2 and A3 of levorin and components A1, A2, A3 and B1 of nystatin had a markedly pronounced membranotropic activity. Ion channel assembly and membrane conductivity were irreversibly controlled by concentration and membrane potential. Changes in selectivity of biomolecular lipid membranes depended on the structure of the antibiotics. The action of the levorin and nystatin components was based on increasing membrane conductivity by the mechanism of ion channel formation with parameters altering in relation to the antibiotic structure. Recommendations for directed synthesis of the antibiotic derivatives with high therapeutic efficacy are presented.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers / Q000494:pharmacology; D008563:Membrane Lipids / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009761:Nystatin / Q000494:pharmacology*; D010743:Phospholipids / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010743:Phospholipids; D009761:Nystatin; D002174:Candicidin
Issledovanie mekhanizma vzaimodeĭstviia individual'nykh komponentov preparatov levorina i nistatina s lipidnymi membranami.