Developmental expression and regional distribution of the scrapie-associated protein mRNA in the rat central nervous system.
The scrapie associated protein (SAP) has been shown to be a normal brain protein of yet undefined function. This study demonstrates that rat brain SAP mRNA levels undergo a transcriptionally dependent increase during normal development. The interregional variation in the adult rat central nervous system (CNS) is roughly 10 fold, with highest levels in the basal ganglion/thalamus and lowest levels in the spinal cord.
D000818:Animals; D002490:Central Nervous System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D018622:PrP 27-30 Protein; D012313:RNA; D018075:RNA, Complementary; D012333:RNA, Messenger / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions; D014158:Transcription, Genetic
D009419:Nerve Tissue Proteins; D018075:RNA, Complementary; D012333:RNA, Messenger; D018622:PrP 27-30 Protein; D012313:RNA