title: The distribution of substance P-, CGRP-, galanin- and ANP-like immunoreactive nerves in human sweat glands.
abstract: The distribution in immunoreactivities towards atrial natriuretic peptide, calcitonin gene-related peptide, galanin and substance P were demonstrated in human skin at the light and electron microscopic levels. Nerves immunoreactive to the first three of these peptides were found around eccrine sweat glands, whereas only a few positively-labelled nerve fibres could be seen around apocrine glands. At the ultrastructural level, immunoreactivity to the neuropeptides was localized in the large dense-cored vesicles of the nerve terminals. No immunoreactivity to substance P could be detected around sweat glands. In addition to these findings, the four types of immunoreactivity were seen in the thick preterminal nerve bundles.
mesh_terms: D009320:Atrial Natriuretic Factor / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D019004:Galanin; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009479:Neuropeptides / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D013545:Sweat Glands / Q000294:innervation* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D009479:Neuropeptides; D010455:Peptides; D013373:Substance P; D009320:Atrial Natriuretic Factor; D019004:Galanin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide