Hemodynamic effects of colloid concentration in experimental hemorrhage: a comparison of Ringer's acetate, 3% dextran-60, and 6% dextran-70.
Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for one hour preoperatively (baseline data). After surgical trauma (arthroplasty), three 0.5 L of arterial blood samples were withdrawn and replaced with autologous red cells mixed with one liter of 3% dextran-60 in one group 1 (n = 9), one liter of 6% dextran-70 in group 2 (n = 10), and 3 L of Ringer's acetate in group 3 (n = 9). Pulmonary capillary wedge pressure (WP) was kept at baseline level for a further 10 h with infusion of the respective fluid; for this purpose, groups 1 through 3 needed additional infusions of 0.8 +/- 0.3, 0.5 +/- 0.4, and 5.3 +/- 3 (SD) L, respectively. Group 1 showed the highest jejunal capillary blood flow at 10 h and the lowest intragroup variations in hemodynamic and respiratory data. Group 2 had the highest pulmonary arterial pressures and group 3 had the lowest colloid oncotic and arterial BP and left ventricular volume indices. In group 3, the Hct and serum albumin indicated insufficient plasma volume replacement. This group had a significantly larger (p less than .05) amount of tissue water in skin, skeletal muscle, and jejunum than the other groups; no significant difference in lung or heart muscle water was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001178:Arthroplasty; D001810:Blood Volume; D001834:Body Water; D003102:Colloids / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D013552:Swine
D003102:Colloids; D003911:Dextrans; D007552:Isotonic Solutions; C028570:Ringer's acetate