title: Expression of haematopoietic progenitor cell-associated antigen BI-3C5/CD34 in leukemia.
abstract: The expression of progenitor cell-associated antigen CD34, defined with monoclonal antibody BI-3C5, was investigated in cells from 109 patients with leukaemia. No reactivity was found in chronic leukaemias, whereas 31% of acute myelogenous leukaemia (AML) and most non-T, non-B acute lymphoblastic leukaemia (ALL) expressed CD34. Examples of BI-3C5+ AML included M1 and M2 FAB types only; all but one were myeloperoxidase positive. In combination with pan-myeloid markers, BI-3C5 is useful for identification of immature myeloid cells.
authors: Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre-Rebro, Zagreb, Yugoslavia.
authors: D
authors: D
authors: Batinić
authors: R
authors: R
authors: Tindle
authors: D
authors: D
authors: Boban
authors: A
authors: A
authors: Tiefenbach
authors: L
authors: L
authors: Rajić
authors: B
authors: B
authors: Labar
authors: D
authors: D
authors: Nemet
authors: M
authors: M
authors: Boranić
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D018952:Antigens, CD34; D000943:Antigens, Differentiation / Q000096:biosynthesis*; D002648:Child; D006801:Humans; D007938:Leukemia / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D018952:Antigens, CD34; D000943:Antigens, Differentiation