Intermingled skin grafts with in vitro cultured keratinocytes--experiments with rats.
In vitro cultured autogenic keratinocytes were used instead of autogenic skin islets in intermingled skin grafts on rats. According to the observations made with the original method, the allogenic epidermis is being rejected. The cultured keratinocytes start to grow out in circles, eventually covering the remaining allodermis in the form of a multilayered, well-differentiated epidermis. The prospects of these findings for possible future clinical applications are discussed.
Hafemann
B
B
Clinic of Burns, Plastic- and Reconstructive Surgery, RWTH Aachen, FRG.
Frese
C
C
Kistler
D
D
Hettich
R
R
D000818:Animals; D002478:Cells, Cultured; D000078404:Epidermal Cells; D004847:Epithelial Cells; D005260:Female; D006084:Graft Rejection; D007633:Keratins; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012867:Skin / Q000166:cytology; D016038:Skin Transplantation; D014945:Wound Healing
D007633:Keratins