Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects.
Hemoglobin is widely used as an inhibitor of EDRF effects. Hemoglobin contracts pig coronary arteries in vitro. However, during this contraction, effects of substance P and bradykinin which act via the EDRF are not inhibited. This means that the hemoglobin contraction is not caused by inhibition of the EDRF. This contraction is caused by a substance released from the endothelium, and by eicosanoïds released from the smooth muscles.
Bény
J L
JL
Département de Biologie Animale, Université de Genève, Switzerland.
Brunet
P C
PC
Van der Bent
V
V
D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors; D004730:Endothelium, Vascular / Q000502:physiology*; D006454:Hemoglobins / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008706:Methemoglobin / Q000494:pharmacology; D009569:Nitric Oxide; D010108:Oxyhemoglobins / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects
D001685:Biological Factors; D016861:Cyclooxygenase Inhibitors; D006454:Hemoglobins; D016859:Lipoxygenase Inhibitors; D010108:Oxyhemoglobins; D009569:Nitric Oxide; D013373:Substance P; D009637:Masoprocol; D008706:Methemoglobin; D001920:Bradykinin; D007213:Indomethacin