title: Changes of antithrombin III (AT III) in AT III deficient patients during long-term anticoagulant treatment.
abstract: Antithrombin III deficient patients with manifest thromboembolic diseases need long term coumarin treatment. There are contradictory data on the change of AT III during this therapy. The authors observed 5 patients with severe AT III decrease type I, 3 with functional abnormality and 2 with a pathological heparin binding. AT III function was determined by the Gerendás-Rák method and with chromogenic substrate. AT III antigen was measured with Behring M-Partigen and Laurell rocket electrophoresis. Crossed immunoelectrophoresis was carried out in all patients. In patients with type I AT III decrease, AT III hasn't changed even in a long period of more than 10 years. In the other types AT III became normal. The pathological heparin binding wasn't changed.
authors: First Department of Internal Medicine, Medical School, Medical University of Pécs, Hungary.
authors: I
authors: I
authors: Nagy
authors: H
authors: H
authors: Losonczy
authors: C
authors: C
authors: Temesi
authors: V
authors: V
authors: Pálmai
authors: E
authors: E
authors: Storcz
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D000990:Antithrombin III / Q000378:metabolism*; D020152:Antithrombin III Deficiency; D006801:Humans; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D000990:Antithrombin III