Anaphylatoxin-induced release of histamine from in vitro perfused guinea pig kidney.
The effect of porcine C5a des Arg and C3a, given as a bolus injection, in the isolated constant flow pump-perfused guinea-pig kidney was investigated. Only C5a des Arg showed activity which was manifested by a dose-dependent increase in perfusion pressure (PP, due to vasoconstriction) and histamine release. Although histamine release was substantial, it alone could not account for the increase in PP. The two more likely causes are a direct vasoconstrictor effect and the release of other mediators.
Abdullah
N A
NA
Department of Pharmacology, University College London, UK.
Assem
E S
ES
Damerau
B
B
D000706:Anaphylatoxins / Q000494:pharmacology*; D000818:Animals; D003176:Complement C3 / Q000276:immunology; D015926:Complement C3a; D003182:Complement C5 / Q000031:analogs & derivatives / Q000276:immunology; D015937:Complement C5a, des-Arginine; D006168:Guinea Pigs; D006636:Histamine Release; D066298:In Vitro Techniques; D007668:Kidney / Q000276:immunology*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010477:Perfusion; D012079:Renal Circulation / Q000187:drug effects
D000706:Anaphylatoxins; D003176:Complement C3; D003182:Complement C5; D015937:Complement C5a, des-Arginine; D010455:Peptides; D015926:Complement C3a