Evidence for posttranslational control of fetal hemoglobin synthesis.
Subunit competition experiments were conducted by recombining various amounts of alpha-subunits with an equimolar mixture of gamma- and beta A-subunits. The results showed that gamma-subunits combine with alpha-subunits less readily than beta A-subunits. Thus, in the presence of alpha-chain deficiency (alpha-thalassemia) the formation of HbA is preferred over HbF, resulting in a decrease in the level of the latter.
Qiu
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CC
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Abraham
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EC
D002851:Chromatography, High Pressure Liquid; D005319:Fetal Hemoglobin / Q000032:analysis / Q000096:biosynthesis* / Q000145:classification; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D014176:Protein Biosynthesis; D013789:Thalassemia / Q000097:blood*
D006441:Hemoglobin A; D005319:Fetal Hemoglobin