Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells.
Effects of neuroleptics and tricyclic antidepressants on voltage-gated ion channels were investigated in the neuroblastoma cell line N1E-115 using the whole cell variation of patch electrode voltage-clamp techniques. Imipramine, chlorpromazine and haloperidol in micromolar concentrations blocked sodium, calcium and potassium channel currents in a reversible and concentration-dependent manner. The order of potency was chlorpromazine greater than imipramine greater than haloperidol. These direct blocking actions on neuronal ion channels might play a role in clinical effects of these drugs.
Ogata
N
N
Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
Yoshii
M
M
Narahashi
T
T
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma; D011619:Psychotropic Drugs / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000502:physiology*
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D007473:Ion Channels; D011619:Psychotropic Drugs