Effects of calcium channel activators on the response of rabbit aortic rings to alpha 1-receptor agonists: evidence for two modes of action.
The interaction between activators of the calcium channel and the alpha 1-adrenoceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of alpha 1-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for alpha 1-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the alpha 1-receptor.
Babich
M
M
Department of Pharmacology, University of Kentucky Medical Center, Lexington.
Butler
B T
BT
Piascik
M T
MT
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001665:Binding Sites; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D018377:Neurotransmitter Agents / Q000378:metabolism; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D002120:Calcium Channel Agonists; D002395:Catecholamines; D018377:Neurotransmitter Agents; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D012110:Reserpine