Absence of cytokeratin 8 and inconsistent expression of cytokeratins 7 and 19 in human basal cell carcinoma.
The expression of the low molecular weight cytokeratins (K) 7, 8, 18, 19 and the high molecular weight cytokeratin 10 in 21 basal cell carcinoma (BCC) was studied using seven different monoclonal antibodies (MoAbs) with specific anti-cytokeratin activity. MoAbs RCK 105 (anti-K7), RPN 1164 (anti-low molecular weight cytokeratins of basic group), Ks 19.1 (anti-K19) and Cam 5.2 (anti-K8, K18, K19) reacted positively but inconsistently in the BCC that were examined. MoAbs 1166 (anti-K8) and RGE53 (anti-K18) did not react at all. MoAb RKSE 60 (anti-K10) did not react with the tumor cells. From the results of this study, it can be concluded that cytokeratins 7 and 19 are expressed in BCC (43% and 71%, respectively), whereas cytokeratin 8 is not expressed.
Habets
J M
JM
Departments of Dermato-Venereology, Erasmus University Rotterdam, The Netherlands.
Tank
B
B
Vuzevski
V D
VD
Brevé
J
J
Stolz
E
E
van Joost
T
T
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002280:Basal Cell Carcinoma / Q000473:pathology*; D006801:Humans; D007633:Keratins / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D008875:Middle Aged; D008970:Molecular Weight; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D007633:Keratins