Strain differences in histamine release from mouse peritoneal mast cells induced by compound 48/80 or A23187.
Strain differences among BALB/c, BDF1, CDF1, C3 H/He, C57 BL/6, DBA/2, ddy and ICR mice were investigated with respect to the ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80, a Ca2+ dependent histamine releaser, and the Ca2+ ionophore A23187. The ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80 were found to be high in BALB/c, ddY and ICR mice, but low in BDF1, CDF1, C3 H/He, C57 BL/6 and DBA/2 mice. Those induced by Ca2+ ionophore A23187 were high in BALB/c, BDF1, CDF1, C3 H/He, DBA2, ddy and ICR mice but low in C57 BL/6 mice. These results indicate that differences in histamine release from mouse peritoneal mast cells are strain dependent.
Toda
S
S
Central Animal Laboratory, Kansai College of Acupuncture Medicine, Osaka, Japan.
Kimura
M
M
Tohya
K
K
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D010529:Peritoneal Cavity / Q000166:cytology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine