[Effect of catecholamines and serotonin on RNA-synthesizing activity in isolated nuclei and chromatin of the rat brain and liver].
It has been shown that intraperitoneal injections of L-DOPA cause an increase in the matrix activity of chromatin and stimulate the incorporation of [3H]uridine into the nuclear fraction of rat brain cells by 35%. In vitro studies have shown that preincubation of brain chromatin with L-DOPA diminishes the inhibiting effect of actinomycin D on RNA synthesis. It has been found that the rate of RNA synthesis in vitro depends on concentrations of catecholamines (L-DOPA, dopamine, norepinephrine) and serotonin.
Arkhipova
L V
LV
Tret'iak
T M
TM
Ozolin'
O N
ON
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D066298:In Vitro Techniques; D007980:Levodopa / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013698:Templates, Genetic
D002395:Catecholamines; D002843:Chromatin; D012701:Serotonin; D007980:Levodopa; D012313:RNA; D012321:DNA-Directed RNA Polymerases
Vliianie katekholaminov i serotonina na RNK-sinteziruiushchuiu sposobnost' izolirovannykh iader i khromatina mozga i pecheni krys.