[Effect of hypotensive therapy on a receptor-dependent increase in Ca2+ in the thrombocytes of patients with hypertension].
The effect of antihypertensive drugs on receptor-dependent increase in Ca2+ basal level and its changes under stimulators action (thrombocytes activating factor, ADP and vasopressin) were studied by means of a fluorescent calcium probe "quin-2". Nifedipine blocked receptor-dependent increase of Ca2+ in thrombocytes in vitro as well as by oral administration, which was accompanied by decrease in vascular tone and BP. The degree of BP decrease correlated with that of depression of receptor-dependent increase of Ca2+ in thrombocytes. Combined therapy including nifedipine, propranolol and a diuretic resulted in more manifest inhibition of receptor-dependent calcium channels than monotherapy with nifedipine. Effect of antihypertensive drugs evidently depends on their influence on receptor-dependent Ca2+ cellular entrance.
Kravchenko
A N
AN
Shkhvatsabaia
I K
IK
Nekrasova
A A
AA
Men'shikov
M Iu
MIu
Avdonin
P V
PV
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D002118:Calcium / Q000097:blood*; D002120:Calcium Channel Agonists; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*
D000959:Antihypertensive Agents; D002120:Calcium Channel Agonists; D007473:Ion Channels; D011956:Receptors, Cell Surface; D002118:Calcium
Vliianie gipotenzivnoĭ terapii na retseptorzavisimoe povyshenie soderzhaniia Ca2+ v trombotsitakh bol'nykh gipertonicheskoĭ bolezn'iu.