title: Influence of drugs on the TXA2/PGI2 balance and on the atherogenic index in myocardial ischemia in dogs.
abstract: The effect of drugs on eicosanoid production and on the development of atherogenic index was investigated in canine myocardial ischemia. Iloprost, verapamil, the trapidil derivative AR 12463 or 0.9% NaCl solution were administered 60 min after coronary artery ligation in anaesthetized dogs. Both iloprost and AR 12463 reduced the thromboxane A2/prostacyclin (TXA2/PGI2) ratio in coronary sinus plasma in comparison to controls. The atherogenic index was significantly decreased in the iloprost as well as in the AR 12463-treated group in comparison to the control group. Verapamil had no influence on the investigated parameters.
authors: Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
authors: A
authors: A
authors: Beitz
authors: C
authors: C
authors: Taube
authors: J
authors: J
authors: Beitz
authors: H
authors: H
authors: Goos
authors: J
authors: J
authors: Graff
authors: J
authors: J
authors: Nohring
authors: K F
authors: KF
authors: Lindenau
authors: H J
authors: HJ
authors: Mest
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D004285:Dogs; D011464:Epoprostenol / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D016285:Iloprost; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D012016:Reference Values; D013928:Thromboxane A2 / Q000097:blood*; D014192:Trapidil / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D011743:Pyrimidines; D013928:Thromboxane A2; D011464:Epoprostenol; D014192:Trapidil; D016285:Iloprost; C053729:AR 12463