Absence of competitive interactions among axon terminals of regenerating motor neurons.
Competition among axon terminals is usually considered to contribute to the formation of patterned synaptic connections. During axonal regeneration of motor neurons in the cockroach, leg muscles initially become innervated by appropriate and inappropriate motor neurons. All axon terminals from inappropriate neurons eventually are eliminated, resulting in the reformation of the original innervation pattern. Destruction of an identified motor neuron by the intracellular injection of pronase did not prevent the elimination of inappropriate axon terminals in the muscle normally innervated by that motor neuron. Therefore, competition does not play a role in the reinnervation of the leg muscles. This indicates a major role for specific cell-cell recognition.
Denburg
J L
JL
Biology Department, University of Iowa, Iowa City 52242.
Powell
S L
SL
Murphy
B F
BF
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology*; D003058:Cockroaches; D006735:Horseradish Peroxidase; D009046:Motor Neurons / Q000502:physiology*; D009416:Nerve Regeneration; D011402:Pronase / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D011402:Pronase