title: Presence of a substance P-like immunoreactive neurone system from the parabrachial area to the central amygdaloid nucleus of the rat with reference to coexistence with calcitonin gene-related peptide.
abstract: An ascending neurone system containing substance P-like immunoreactivity (SPI) from the lateral parabrachial nucleus (PBL) to the central amygdaloid nucleus (AC) was detected. Destruction of the external subdivision of the PBL resulted in a marked ipsilateral reduction of SPI fibres in the AC, which suggests that SPI neurones project mainly ipsilaterally to the AC. This was supported by the findings that injection of biotin-wheatgerm agglutinin into the AC labelled many neurones in the ipsilateral external subdivision of the PBL. Simultaneous staining with antiserum showed that some of these neurones contain SP. Immunohistochemical double-staining revealed that almost all of the SPI neurones in the external subdivision of the PBL contained calcitonin gene-related peptide.
authors: Department of Anatomy II, Osaka University Medical School, Japan.
authors: M
authors: M
authors: Yamano
authors: C J
authors: CJ
authors: Hillyard
authors: S
authors: S
authors: Girgis
authors: I
authors: I
authors: MacIntyre
authors: P C
authors: PC
authors: Emson
authors: M
authors: M
authors: Tohyama
mesh_terms: D000679:Amygdala / Q000166:cytology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D007150:Immunohistochemistry; D009434:Neural Pathways / Q000166:cytology; D009474:Neurons / Q000032:analysis; D009479:Neuropeptides / Q000032:analysis*; D051381:Rats; D013373:Substance P / Q000032:analysis*
chemical_list: D009479:Neuropeptides; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide