gamma-Preprotachykinin-(72-92)-peptide amide potentiates substance P-induced salivation.
The effects of gamma-preprotachykinin-(72-92)-peptide amide [gamma-PPT-(72-92)-NH2] on salivation in the rat were investigated and were compared with salivation responses elicited by a variety of other tachykinin and related peptides. On intravenous injection or continuous infusion, gamma-PPT-(72-92)-NH2, a naturally occurring N-terminally extended derivative of neurokinin A (NKA), potently stimulated salivation. The rank order of potency of peptides that stimulated salivation was: NPK greater than gamma-PPT-(72-92)-NH2 greater than substance P greater than NKA = Asp-Ala-NKA. Moreover, gamma-PPT-(72-92)-NH2, like NPK, potentiated the effects of substance P on salivary secretion. These results indicate that the actions of gamma-PPT-(72-92)-NH2 may be pharmacologically or physiologically relevant in the actions of tachykinin peptides.
Takeda
Y
Y
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.
Krause
J E
JE
D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012472:Salivation / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D015320:Tachykinins / Q000494:pharmacology*
D010446:Peptide Fragments; D011498:Protein Precursors; D015320:Tachykinins; C044206:preprotachykinin; C059905:tachykinin neuropeptide gamma; D013373:Substance P