Comparison of the effects of cetamolol and atenolol on epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs.
Epinephrine-induced hypokalemia is a beta 2-adrenoceptor-mediated effect known to occur in patients after acute myocardial infarction. Cetamolol and atenolol are beta-adrenoceptor antagonists that possess cardioselectivity. They were studied for their ability to inhibit epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs at equipotent beta 1-adrenoceptor blocking doses. Cetamolol was able to block epinephrine-induced hypokalemia completely, in a dose-related manner, and to block isoproterenol-induced hypokalemia partially. On the other hand, atenolol could produce only partial blockade of epinephrine-induced hypokalemia in a dose-related manner and had essentially no effect on isoproterenol-induced hypokalemia. These results showed that cetamolol was less cardioselective than atenolol and suggest cetamolol would be more beneficial than atenolol in preventing epinephrine-induced hypokalemia in patients who have an acute myocardial infarction.
Klein
M
M
Department of Pharmacology, Ayerst Laboratories Research, Princeton, New Jersey.
Stupienski
R F
RF
Nettler
S
S
Smith
T
T
Oshiro
G
G
D000081:Acetamides / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007008:Hypokalemia / Q000139:chemically induced / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000097:blood
D000081:Acetamides; D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D007545:Isoproterenol; D011188:Potassium; D004837:Epinephrine; C038931:cetamolol