title: [Alpha-2 macroglobulin from cerebrospinal fluid in neurosurgical diseases].
abstract: Content of alpha 2-macroglobulin (alpha 2-MG) was estimated in cerebrospinal fluid (CSF) of patients with neurosurgical impairments. Minimal content of the globulin was found in patients with brain concussion (0.011 +/- 0.001 g/L, control group), maximal concentration--in severe craniocerebral trauma with brain contraction (0.056 +/- 0.007 g/L) and moderately increased content of alpha 2-MG was detected in intracranial tumors and drug-resistant epilepsy, 0.028 +/- 0.004 g/L and 0.025 +/- 0.004 g/L, respectively. Alteration in content of alpha 2-MG during postoperational period corresponded to clinical state of patients. Estimation of alpha 2-MG in CSF might be used as a criterion of brain impairment severity as well as for monitoring the treatment course.
authors: T G
authors: TG
authors: Vasil'eva
authors: L N
authors: LN
authors: Dobrogorskaia
authors: L N
authors: LN
authors: Kraeva
authors: V P
authors: VP
authors: Goncharova
mesh_terms: D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000601:surgery; D001930:Brain Injuries / Q000134:cerebrospinal fluid / Q000601:surgery; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000601:surgery; D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000601:surgery; D006801:Humans; D000511:alpha-Macroglobulins / Q000134:cerebrospinal fluid*
chemical_list: D000511:alpha-Macroglobulins
vernacular_title: Alpha-2-makroglobulin v spinnomozgovoĭ zhidkosti pri neĭrokhirurgicheskikh zabolevaniiakh.