Voltage-gated currents recorded from the surface of the frog optic nerve.
Macroscopic voltage-dependent currents were recorded from the surface of the intact optic nerve of Rana pipiens using the loose patch clamp technique. Depolarizing steps of more than 40 mV produced sodium-dependent TTX sensitive inward currents and a 4-AP and sodium sensitive fast outward current in addition to a slower outward current. Since the surface of the nerve is a glia limitans, it appears that the membranes of these astrocytes contain both voltage-sensitive sodium and potassium channels.
Ortiz
S
S
Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, Old San Juan.
Rodriguez
O
O
Orkand
P M
PM
Orkand
R K
RK
Marrero
H
H
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D009469:Neuromuscular Junction / Q000502:physiology; D009900:Optic Nerve / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D011894:Rana pipiens; D015222:Sodium Channels / Q000502:physiology; D009435:Synaptic Transmission
D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels