Intravenous fluid therapy in the prehospital management of hemorrhagic shock: improved outcome with hypertonic saline/6% Dextran 70 in a swine model.
The small quantities of 7.5% hypertonic saline (HTS) in 6% Dextran 70 (DEX 70; Travenol Laboratories, Deerfield, IL) required to produce marked improvement in tissue perfusion may make it an ideal solution for the prehospital management of hypotensive trauma patients. This study shows that the initial treatment of porcine hemorrhagic shock with 7.5% HTS/6% DEX 70 results in significantly improved hemodynamics and higher survival rates than those seen in animals treated with normal saline. These results are very encouraging and dictate the need for evaluation in human trials.
Chudnofsky
C R
CR
Department of Emergency Medicine, University of Cincinnati College of Medicine.
Dronen
S C
SC
Syverud
S A
SA
Zink
B J
BJ
Hedges
J R
JR
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004630:Emergencies; D006439:Hemodynamics; D006801:Humans; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*; D012965:Sodium Chloride / Q000627:therapeutic use*; D013552:Swine; D014947:Wounds and Injuries / Q000628:therapy
D003911:Dextrans; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride