Beta 3 subunit of vitronectin receptor is present in osteoclast adhesion structures and not in other monocyte-macrophage derived cells.
The distribution of extracellular matrix receptors in human osteoclasts has been studied; a beta 3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells and not in macrophages from the same source.
Zambonin Zallone
A
A
Institute of Human Anatomy, University of Bari, Italy.
Teti
A
A
Gaboli
M
M
Marchisio
P C
PC
D002448:Cell Adhesion; D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000032:analysis; D005870:Giant Cell Tumors / Q000032:analysis / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000032:analysis; D008264:Macrophages / Q000032:analysis / Q000166:cytology / Q000648:ultrastructure*; D009000:Monocytes / Q000032:analysis / Q000166:cytology / Q000648:ultrastructure*; D010010:Osteoclasts / Q000032:analysis / Q000166:cytology / Q000648:ultrastructure*; D011971:Receptors, Immunologic / Q000032:analysis*; D019030:Receptors, Vitronectin; D016608:Talin; D016596:Vinculin
D003598:Cytoskeletal Proteins; D016023:Integrins; D011971:Receptors, Immunologic; D019030:Receptors, Vitronectin; D016608:Talin; D016596:Vinculin