Immunosuppression after injection of Friend virus into C57BL/6 mice of different ages.
Injection with Friend virus (FV) causes immunosuppression in young and old C57BL/6 mice, i.e. it occurs whether or not the virus replicates very briefly or for a long period. There are only minor age-related differences in the extent of immunosuppression, except that suppression appears to persist somewhat longer in old than in young animals.
Ponnappan
U
U
Department of Immunology, University of Toronto, Ontario, Canada.
Cinader
B
B
Axelrad
A A
AA
Van der Gaag
H C
HC
Koh
S W
SW
D000375:Aging / Q000276:immunology*; D000818:Animals; D005260:Female; D005622:Friend murine leukemia virus / Q000276:immunology* / Q000502:physiology; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007117:Immunization, Secondary; D007132:Immunoglobulin Isotypes / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D010767:Phosphorylcholine / Q000276:immunology; D014779:Virus Replication; D005719:gamma-Globulins / Q000276:immunology
D007132:Immunoglobulin Isotypes; D005719:gamma-Globulins; D010767:Phosphorylcholine