[HIV infection and T-lymphocyte behavior: results of a study in Palermo].
The acquired immunodeficiency syndrome (AIDS) is caused by the HIV infection in people with an already impaired immunological system. The seroprevalence follow-up of different markers of HIV should seem to suggest to predict the course of the disease as well as the T4/T8 ratio did. We examined 111 at risk anti-HIV positive people according to these parameters in comparison with their clinical situation. Serum samples from these subjects were examined by means of the ELISA method for anti-ENV/CORE antibodies and HIV antigen, followed by a Western Blot confirmation. The T4/T8 ratio was controlled and measured by means of monoclonal immunofluorescent antibody test. Sixty six out of eighty three (79.5%) symptomatic patients showed a less than 1.0 T4/T8 ratio in comparison with 15/28 (53.6%) asymptomatic people (p less than 0.01) while no difference was seen in the same patients according to the presence or not of anti-core antibodies. In some patients it was possible to observe a positive trend in the T4/T8 ratio.
Cangelosi
C
C
Giardina
R A
RA
Pecoraro
G
G
Marcianò
R
R
Vitale
M G
MG
Gullotti
A
A
Caronia
F
F
Spanò
C
C
D015496:CD4-Positive T-Lymphocytes; D005500:Follow-Up Studies; D015683:Gene Products, gag / Q000276:immunology; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D050378:T-Lymphocytes, Regulatory; D014758:Viral Core Proteins / Q000276:immunology
D015683:Gene Products, gag; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D014758:Viral Core Proteins
Infezioni da HIV e comportamento di linfociti T: risultati di uno studio palermitano.