title: The use of non-specific immunopotentiators in experimental Trypanosoma cruzi infection.
abstract: The effects of levamisole, isoprinosine and Corynebacterium parvum on Trypanosoma cruzi (Y strain) experimental infection of mice were studied. In prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings. Levamisole and isoprinosine had no effect when used after infection. Electrocardiograms were obtained from all chronic chagasic mice. The most frequent changes were left atrial overload and first degree atrio-ventricular block. These findings became more frequent the longer the animals survived. The net effect of the non-specific immunopotentiators seems to depend on several factors: host immune state, severity of infection, dose and timing of drug administration. This probably explains the variable published results and the paradoxical findings of different laboratories.
authors: Centro de Pesquisas Aggeu Magalhães (Fundação Oswaldo Cruz), Recife, Brazil.
authors: F G
authors: FG
authors: Abath
authors: E M
authors: EM
authors: Coutinho
authors: S M
authors: SM
authors: Montenegro
authors: Y M
authors: YM
authors: Gomes
authors: A B
authors: AB
authors: Carvalho
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use; D002598:Chagas Cardiomyopathy / Q000473:pathology; D014355:Chagas Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004562:Electrocardiography; D007542:Inosine Pranobex / Q000627:therapeutic use; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009206:Myocardium / Q000473:pathology; D011425:Propionibacterium acnes
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D007978:Levamisole; D007542:Inosine Pranobex