Gastrin-producing ovarian cystadenocarcinoma: sensitivity to secretin and SMS 201-995.
We report a patient with severe peptic ulcer disease and a right ovarian mass that was found to be a gastrin-producing cystadenocarcinoma. Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995. Following resection of the tumor, serum gastrin levels and the gastrin response to secretin returned to normal. Histologic examination, including Alcian blue staining for mucin and immunoperoxidase staining for gastrin, revealed gastrin at the base and mucin at the apex of the tumor cells. This report demonstrates secretin stimulation and somatostatin inhibition of gastrin secretion from a cell that is apparently not of endocrine origin.
Heyd
J
J
Department of Medicine, Shaare-Zedek Medical Center, Jerusalem, Israel.
Livni
N
N
Herbet
D
D
Mor-Yosef
S
S
Glaser
B
B
D003536:Cystadenocarcinoma / Q000032:analysis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D015282:Octreotide; D010051:Ovarian Neoplasms / Q000032:analysis / Q000378:metabolism* / Q000601:surgery; D010053:Ovary / Q000032:analysis; D010437:Peptic Ulcer / Q000209:etiology; D012633:Secretin; D013194:Staining and Labeling
D005755:Gastrins; D012633:Secretin; D015282:Octreotide