Attempts to suppress experimental allergic encephalomyelitis in rats with alpha fetoprotein.
Rats of the Lewis strain were immunized with bovine basic myelin protein to develop experimental allergic encephalomyelitis. Neither human nor rat fetal sources of purified alpha-fetoprotein were able to significantly ameliorate the development of this dyscrasia. The plasma of pregnant rats at term was without effect. Immunization of pregnant rats was also accompanied by the usual course of development of typical encephalomyelitis.
Kikukawa
A
A
Department of Physiological Chemistry, University of Wisconsin, Madison.
Peterson
B S
BS
Deutsch
H F
HF
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000517:prevention & control*; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew; D012709:Serum Albumin / Q000032:analysis / Q000494:pharmacology; D000509:alpha-Fetoproteins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*
D005227:Fatty Acids; D012709:Serum Albumin; D000509:alpha-Fetoproteins