title: Midline and temporal lobe MLRs in the guinea pig originate from different generator systems: a conceptual framework for new and existing data.
abstract: In the guinea pig and gerbil, individual components within the MLR time frame differ in optimal recording location. Specifically, MLR components obtained from the midline differ from those obtained over the temporal lobe. In the present paper midline and temporal lobe components were shown to differ not only in scalp topography but also in response to the following experimental manipulations: intracortical injection of neural inactivating agents (lidocaine and kainic acid), temporal lobe ablation, electrolytic lesions, systemic anesthesia, stimulation rate and course of development. Since midline and temporal lobe components respond differently to experimental manipulations, it can be concluded that the midline and temporal lobe responses are mediated by different generator sources. The particular orientation of the generators responsible for the MLR in the guinea pig and gerbil facilitates the identification of individual components. Results from simultaneous recordings of these components during experimental manipulations support the hypothesis of multiple MLR generators in laboratory animals and provide insight into the generators and developmental aspects of the MLR in humans.
authors: Electrophysiology Lab, Siegel Institute, Michael Reese Medical Center, Chicago, IL 60616.
authors: N
authors: N
authors: Kraus
authors: D I
authors: DI
authors: Smith
authors: T
authors: T
authors: McGee
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000768:Anesthesia, General; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology; D001306:Auditory Pathways / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D005849:Gerbillinae / Q000502:physiology*; D006168:Guinea Pigs / Q000502:physiology*; D007608:Kainic Acid / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D009407:Nerve Block; D011930:Reaction Time; D012535:Scalp / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology*
chemical_list: D008012:Lidocaine; D007608:Kainic Acid