Lack of cross-reaction between myelin basic proteins and putative demyelinating virus envelope proteins.
No cross-reaction could be detected between purified myelin basic proteins (MBP) from mouse, rat or human origins and envelope proteins of viruses suspected of inducing demyelinating processes. In the experimental model using Theiler's murine encephalomyelitis virus, competition radioimmunoassay failed to detect any cross-reaction between MBP and VP1, VP2 and VP3 envelope antigens. In the human situation, antibodies against SV5 and measles viruses, both etiologically linked with multiple sclerosis, also failed to recognize MBP. These results rule out molecular mimicry as a cause of demyelination.
Rubio
N
N
Instituto Cajal, Department of Neuroimmunology, Velazquez, Madrid, Spain.
Cuesta
A
A
D000328:Adult; D000368:Aged; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D004680:Maus Elberfeld virus / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D015301:Retroviruses, Simian / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
D000956:Antigens, Viral; D004676:Myelin Basic Protein; D014759:Viral Envelope Proteins