Histologic changes in dog lymph nodes after endolymphatic application of bleomycin oil suspension.
Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment). Granulomatous reaction, microabscesses, and small necrotic foci were observed. After a month, fibrosis was detectable in all lymph nodes. The damage to microscopic lymph node structures after Oil-Bleo was moderate. These findings suggest that Oil-Bleo may be useful in local treatment of lymph node metastases.
Hirnle
P
P
Department of Gynecology and Obstetrics, University of Tübingen, West Germany.
Geppert
M
M
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D007272:Injections, Intralymphatic; D008198:Lymph Nodes / Q000187:drug effects*; D009821:Oils; D013535:Suspensions; D013997:Time Factors
D009821:Oils; D013535:Suspensions; D001761:Bleomycin