Variability in the geometry of RNA double helices generated from dinucleoside building-blocks.
A graphical method is presented for the generation of helical parameters from single-crystal structures of RNA nucleic acid fragments that are minimally dinucleosides. The method is compared with other published procedures, for a number of text examples. The RNA double helices generated from three different salts of the dinucleoside monophosphate GpC are examined in relation to the variations in helix morphology that are produced. It is shown that small differences between these GpC salts can be amplified to very distinct helix characteristics.
Aggarwal
A
A
CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, UK.
Neidle
S
S
D015226:Dinucleoside Phosphates; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D012313:RNA
D015226:Dinucleoside Phosphates; C004804:guanylyl-(3',5')-cytidine; D012313:RNA