[The investigation of asthmatic children by multiple factor analysis. III. The changes in allergic factors selected by multiple factor analysis in 3 anti-allergic during treated groups over one year].
We investigated the difference in the influence on 10 allergic factors of 3 anti-allergic drugs: azelastine, tranilast, ketotifen. We determined the ranking of 10 allergic factors using the relative range ratio calculated by Multiple factor analysis. The ranking as follows: (1) Eosinophil count (2) IgE RAST score to H.D. (3) IgG4 antibody titers to egg white (4) IgE RAST score to egg white (5) IgE RAST score to D.f. (6) IgG4 antibody titers to milk (7) IgE RIST (8) IgG4 antibody titers to soybean (9) IgE RAST score to soybean (10) IgE RAST score to milk. Then we split 122 asthmatic children (mean age: 9.3) into 3 groups and gave each group a different one of the 3 anti-allergic drugs for one year. From daily records of asthma attacks and clinical findings, we classified the children into improved and not-improved groups within their respective anti-allergic drug group, and we investigated the changes in and the change ratios of the 10 allergic factors by the Student t method over this one year. The results were as follows. 1) There was no difference in the chang of 3 allergic factors (Eosinophil count, IgG4 antibody titers to egg white and IgE RIST) among the 3 anti-allergic drug treated groups. 2) The specific IgE antibodies to H.D. and D.f. had a remarkable decline tendency in treated groups by azelastine and tranilast. 3) The specific IgE antibody to egg white had a remarkable decline tendency in treated group by ketotifen.
Koya
N
N
Moroi
T
T
Hara
M
M
Suzuki
S
S
Tateno
A
A
Nagata
K
K
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007665:Ketotifen / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D015999:Multivariate Analysis; D010793:Phthalazines / Q000627:therapeutic use*; D011379:Prognosis; D011724:Pyridazines / Q000627:therapeutic use*; D011852:Radioallergosorbent Test; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D007074:Immunoglobulin G; D010793:Phthalazines; D011724:Pyridazines; D062367:ortho-Aminobenzoates; C012293:tranilast; D007665:Ketotifen; C020976:azelastine