Distance analysis and sequence properties of functional domains in nucleic acids and proteins.
We present a unified algorithm to analyze distances between short oligomers in large collections of nucleic acids and protein sequences (DISTANP). This extended version of DISTAN methodology not only permits analysis of distances between selected pairs of oligomers, but also allows a user to analyze distances between groups of residues (such as acidic and hydrophobic amino acids). This capacity allows differentiation of sequence properties of known functional domains in nucleic acids and proteins.
Konopka
A K
AK
National Cancer Institute, Laboratory of Mathematical Biology, Frederick, MD 21701.
Chatterjee
D
D
D000465:Algorithms; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis*
D011506:Proteins; D012313:RNA; D004247:DNA