The effect of peptides on the motility of the stomach, intestine and rectum in the skate (Raja).
1. Pentagastrin (10(-8)-2 X 10(-6) M) was found to increase motor activity in the cardiac stomach and spiral intestine but only occasionally in the pyloric stomach and not at all in the rectum. 2. Substance P increased motor activity in both parts of the stomach and the rectum (10(-8)-5 X 10(-7) M) but had only a slight effect on the spiral intestine. 3. No effect on the activity of any part of the gut was seen with VIP (10(-7) M), neurotensin (2 X 10(-6) M) or bradykinin (2 X 10(-5) M). 4. The responses to pentagastrin or substance P were not abolished by TTX (10(-6) M). 5. The implications of these results for the understanding of the control of gut motility in elasmobranchs is discussed.
Andrews
P L
PL
Department of Physiology, St George's Hospital Medical School, Tooting, London, UK.
Young
J Z
JZ
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004555:Electric Fish / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D009496:Neurotensin / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D012007:Rectum / Q000187:drug effects; D012860:Skates, Fish / Q000502:physiology*; D013270:Stomach / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D010455:Peptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D013779:Tetrodotoxin; D010418:Pentagastrin; D001920:Bradykinin