A T cell epitope for experimental allergic neuritis.
A synthetic peptide representing residues 57-81 of the bovine P2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57-81 could also be used to stimulate a P2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60-81 produced a milder form of clinical disease. Residues 60-81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic alpha-helical structures.
Olee
T
T
Department of Neurology, Medical University of South Carolina, Charleston 29425.
Powers
J M
JM
Brostoff
S W
SW
D000818:Animals; D000939:Epitopes; D008213:Lymphocyte Activation; D004676:Myelin Basic Protein / Q000276:immunology*; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D011487:Protein Conformation; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D010455:Peptides