CD-1 (T6), HLA-DR-expressing cells, presumably Langerhans cells, in nasal mucosa.
In the skin, epidermal Langerhans cells (LC) constitute a major population of antigen-presenting cells. These cells are characterized by the expression of both CD-1 (T6) and HLA-DR on the cell membrane. We wanted to know whether similar CD-1/HLA-DR-positive cells occur in the nasal mucosa of patients with an isolated grass pollen allergy and in non-allergic controls. CD-1/HLA-DR-positive dendritic cells were found in columnar and cuboidal epithelium and the lamina propria of the nasal mucosa. These CD-1/HLA-DR-positive cells presumably correspond with LC in the skin. We also found significantly more CD-1-positive cells in nasal biopsy samples of allergic than in those of the non-allergic controls. In the allergic patients some of the CD-1-positive cells were found to be surface IgE-positive, possibly due to passive adherence of IgE to Fc receptors.
Fokkens
W J
WJ
Dept. of Otorhinolaryngology, Leyenburg Hospital, The Hague, The Netherlands.
Vroom
T M
TM
Rijntjes
E
E
Mulder
P G
PG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D000943:Antigens, Differentiation / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000032:analysis* / Q000166:cytology; D013223:Statistics as Topic
D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D006684:HLA-DR Antigens; D007073:Immunoglobulin E