title: A genetic electrophoretic variant of high-sulfur hair proteins for forensic hair comparisons. I. Characterization of variant high-sulfur proteins of human hair.
abstract: In a survey of the proteins from human hair, a genetic electrophoretic variant has been observed in the high-sulfur protein region. S-carboxymethylated proteins were examined by 15% polyacrylamide gel electrophoresis at pH 8.9. Out of 150 unrelated samples of Japanese head hairs analyzed, 107 showed 6 major high-sulfur protein bands (normal) and the remaining 43 samples showed an additional high-sulfur protein band (variant). Of 21 Caucasian samples analyzed only one variant sample was found. Characterization of the proteins by two-dimensional electrophoresis evidenced a variant protein spot which showed an apparent molecular weight of 30 k Da. Isoelectric points of the high-sulfur proteins ranged from 3.25-3.55 and that of variant protein band from 3.3-3.4. Family studies of 21 matings resulting in 49 children indicated that this variant was inherited in an autosomal fashion.
authors: B
authors: B
authors: Miyake
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D005554:Forensic Medicine; D006197:Hair / Q000032:analysis*; D006801:Humans; D007564:Japan; D007633:Keratins / Q000032:analysis* / Q000235:genetics; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D013455:Sulfur / Q000032:analysis*
chemical_list: D007633:Keratins; D013455:Sulfur