[Inhibition of HIV reproduction in cultured cells using proteolysis inhibitors].
Treatment of AIDS is a complicated problem since there is a limited set of preparations tested and most of them appear to be ineffective. Their main target is HIV reverse transcriptase. The data presented show that proteolysis inhibitors are able to inhibit HIV reproduction in cell culture. The compounds used in this study, gordox and kontrikal, are officinal drugs and therefore it is worthwhile to study their effect in patients with AIDS.
Bukrinskaia
A G
AG
Korneeva
M N
MN
Nosik
D N
DN
Zhdanov
V M
VM
D007611:Aprotinin / Q000494:pharmacology*; D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D011480:Protease Inhibitors / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C011475:gordox; D007611:Aprotinin
Podavlenie reproduktsii virusa immunodefitsita cheloveka v kul'ture kletok s pomoschch'iu ingibitora proteoliza.