The synergistic effect of serotonin and epinephrine at the level of signal transduction.
Evidence is presented of synergistic interactions occurring between serotonin and epinephrine at the level of signal transduction. Different mechanisms that can explain these synergistic effects are discussed.
de Chaffoy de Courcelles
D
D
Department of Biochemistry, Janssen Pharmaceutica, Beerse, Belgium.
Roevens
P
P
De Clerck
F
F
D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
D011985:Receptors, Serotonin; D012701:Serotonin; D007650:Ketanserin; D002118:Calcium; D004837:Epinephrine