title: Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration.
abstract: The concentrations of bovine acute phase proteins were monitored in plasma following experimental infection with Pasteurella haemolytica and Ostertagia ostertagi and after endotoxin administration. Raised levels of haptoglobin, alpha 1 proteinase inhibitor and seromucoid were detected after pasteurella infection and endotoxin administration. Ceruloplasmin levels increased after endotoxin administration but not during pasteurella infection. Raised levels of the four acute phase proteins were found in eight of 19 calves infected with ostertagia but showed a variable pattern and did not correlate with plasma pepsinogen increases. Bovine alpha 1 antichymotrypsin and alpha 2 macroglobulin were identified as acute phase reactants.
authors: University of Glasgow Veterinary School.
authors: J G
authors: JG
authors: Conner
authors: P D
authors: PD
authors: Eckersall
authors: A
authors: A
authors: Wiseman
authors: R K
authors: RK
authors: Bain
authors: T A
authors: TA
authors: Douglas
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000210:Acute-Phase Reaction / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D002570:Ceruloplasmin / Q000032:analysis; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D007249:Inflammation / Q000662:veterinary*; D008070:Lipopolysaccharides; D008297:Male; D009961:Orosomucoid / Q000032:analysis; D010029:Ostertagiasis / Q000150:complications / Q000662:veterinary*; D010326:Pasteurella Infections / Q000150:complications / Q000662:veterinary*; D011480:Protease Inhibitors / Q000032:analysis; D012772:Shock, Septic / Q000150:complications / Q000662:veterinary*; D014252:Trichostrongyloidiasis / Q000662:veterinary*; D000514:alpha 1-Antichymotrypsin / Q000097:blood; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D004731:Endotoxins; D006242:Haptoglobins; D008070:Lipopolysaccharides; D009961:Orosomucoid; D011480:Protease Inhibitors; D000514:alpha 1-Antichymotrypsin; D000511:alpha-Macroglobulins; C044101:endotoxin, Escherichia coli; D002570:Ceruloplasmin