Myelodysplastic syndromes: analysis of morphological features related to the FAB-classification.
In a retrospective study of 96 patients with a myelodysplastic syndrome, the reproducibility of the French-American-British (FAB) classification was determined. Morphological abnormalities in peripheral blood and bone marrow were studied. Slides were reviewed by 3 examiners. All 3 observers agreed on morphological classification in 61% of cases, pairs of 2 in 64, 76 and 76%. The final diagnosis was refractory anaemia (RA) in 7 patients, acquired sideroblastic anaemia (AISA) in 2, chronic myelomonocytic leukaemia (CMML) in 31, refractory anaemia with excess of blasts (RAEB) in 34 and RAEB in transformation (RAEB-t) in 22. Dyserythropoiesis, dysgranulopoiesis and dysmegakaryopoiesis were found in all FAB subgroups. Dyserythropoiesis was significantly more frequently encountered in RAEB than in RAEB-t and CMML.
van der Weide
M
M
Department of Haematology, Free University, Amsterdam, The Netherlands.
Sizoo
W
W
Krefft
J
J
Langenhuijsen
M M
MM
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000145:classification*; D012189:Retrospective Studies; D013194:Staining and Labeling