[The structuro-functional state of the ischemic myocardium under the action of a terrilitin-nicotinic acid mixture in animal experiments].
Histochemical evidence of the activity and distribution of glycolysis redox enzymes, tissue respiration and terminal oxidation pattern (dehydrogenase of lactic, malic, succinic and isocitric acids, NAD-N- and NADPh-N-ase, cytochrome oxidase) as well as the levels of the major carbohydrates (glycogen, neutral aminopolysaccharides, glucose) were experimentally studied in the cardiomyocytes of myocardial necrotic, perinecrotic and intact areas in the control and in the experimental material under the administration of terrilitin-nicotinic acid mixture. It was stated that the use of aforementioned mixture contributed to the retention of enzymatic activity and optimal levels of energy formation in the cardiomyocytes of the marginal infarction zone and noticeably prevented the destructive involvement of the considered area as well as the impairment of functional activity of oscillating cardiomyocytes. Therefore, the application of the mixture improved the outcome prognosis in acute myocardial infarction.
Mamedov
Ia D
IaD
Garaev
G Sh
GSh
Korkmazov
B M
BM
Mirzabekova
F I
FI
D000681:Amylases / Q000008:administration & dosage*; D000818:Animals; D004338:Drug Combinations / Q000008:administration & dosage; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009525:Niacin / Q000008:administration & dosage*; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D011379:Prognosis; D011817:Rabbits
D004338:Drug Combinations; D009525:Niacin; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Strukturno-funktsional'noe sostoianie ishemizirovannogo miokarda pod vliianiem smesi terrilitin-nikotinovaia kislota v éksperimente.