Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.
The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively. Dopamine receptor and 1,4-dihydropyridine binding densities were decreased by 58% and 43% respectively, with no change in binding affinity for either ligand. 1,4-Dihydropyridine-sensitive Ca2+ channels may be located primarily on postsynaptic elements.
Skattebøl
A
A
Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.
Hruska
R E
RE
Hawthorn
M
M
Triggle
D J
DJ
D000818:Animals; D001665:Binding Sites; D015220:Calcium Channels; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004095:Dihydropyridines / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009553:Nimodipine / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D015220:Calcium Channels; D004095:Dihydropyridines; D007473:Ion Channels; D011954:Receptors, Dopamine; D011978:Receptors, Nicotinic; D013134:Spiperone; D009553:Nimodipine; C038806:1,4-dihydropyridine; D002795:Choline O-Acetyltransferase; D007608:Kainic Acid