The effect of indomethacin on nucleic acids in blood, hemopoietic and lymphoid tissues in continuously irradiated rats.
The effect of indomethacin--a nonsteroid antiinflammatory drug with potential antitumor activity--on the development of radiation-induced changes was followed in blood, bone marrow, spleen, thymus and testes of rats. Indomethacin administered in drinking water (0.7-1.0 mg/kg per day) during a continuous 7-day irradiation with gamma rays (dose rate of 2.055 Gy/day, total accumulated dose of 14.385 Gy) caused a higher and more rapid incorporation of 3H-thymidine into blood DNA, and an increase in blood RNA concentration. The results suggest some stimulation of hemopoiesis recovery by indomethacin treatment in continuously irradiated rats.
Misúrová
E
E
Department of General Biology, Faculty of Science, Safárik University, Kosice, Czechoslovakia.
Kropácová
K
K
Chlebovský
O
O
Pado
D
D
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004247:DNA / Q000032:analysis* / Q000097:blood; D007213:Indomethacin / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D012313:RNA / Q000032:analysis* / Q000097:blood; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry; D013997:Time Factors
D011837:Radiation-Protective Agents; D012313:RNA; D004247:DNA; D007213:Indomethacin