Calbindin-D28K and the peptidergic neuroendocrine system in rat gut: an immunohistochemical study.
Calbindin-D28K was immunohistochemically localized in myenteric and submucosal plexuses throughout the rat intestine. Calbindin-D28K immunoreactivity was found in about half of myenteric neurons and in more than 90% of submucosal neurons. Calbindin-D28K was also observed in nerve processes running inside ganglia, muscle layers and lamina propria. No correlation could be established between the presence of calbindin-D28K and the distribution of neuropeptides localized in this study (VIP, enkephalin, somatostatin and substance P). In addition, some endocrine-like cells of the ileum were calbindin-D28K-positive. Half of these endocrine cells also contained neurotensin but none of the other neuropeptides investigated.
Resibois
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Laboratoire d'Histologie, Faculté de Médecine, Université Libre de Bruxelles, Belgium.
Vienne
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Pochet
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D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D004743:Enkephalin, Leucine / Q000032:analysis / Q000276:immunology; D007150:Immunohistochemistry; D007422:Intestines / Q000166:cytology* / Q000294:innervation; D008297:Male; D009490:Neurosecretory Systems / Q000032:analysis* / Q000166:cytology / Q000276:immunology; D009496:Neurotensin / Q000032:analysis / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G / Q000032:analysis* / Q000276:immunology; D013004:Somatostatin / Q000032:analysis / Q000276:immunology; D013373:Substance P / Q000032:analysis / Q000276:immunology; D014660:Vasoactive Intestinal Peptide / Q000032:analysis / Q000276:immunology
C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D013004:Somatostatin; D004743:Enkephalin, Leucine