Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation.
Immunologically-mediated cellular accumulation was measured 24 hours after antigenic challenge using a rat subcutaneous air pouch model. This response was inhibited by treatment with prednisolone, colchicine, anti-thymocyte serum and systemic antigen. In contrast, administration of a range of other pharmacological and clinically active agents had little effect. The profile of inhibitory activity suggested that this response was mainly due to delayed type hypersensitivity with little anaphylactic or Arthus-type component.
Hambleton
P
P
Roussel Laboratories Limited, Covingham, Swindon, Wilts, UK.
Miller
P
P
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D000941:Antigens / Q000276:immunology; D007611:Aprotinin / Q000494:pharmacology; D001963:Bromelains / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004546:Elapid Venoms / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000473:pathology; D011239:Prednisolone / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D004546:Elapid Venoms; D007106:Immune Sera; D011720:Pyrazoles; C016310:cobra venom factor; D003533:Cyproheptadine; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D002927:Cimetidine; D001963:Bromelains; D007611:Aprotinin; D011239:Prednisolone; D004205:Cromolyn Sodium; D003078:Colchicine; D007213:Indomethacin