Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from mast cells from various locations.
Nedocromil sodium and sodium cromoglycate inhibited histamine release from rat peritoneal mast cells. Tachyphylaxis was observed with both drugs. The 2 compounds were extremely selective in their action, being less active against peritoneal mast cells from the hamster and completely ineffective against mast cells from the mouse. Human basophil leucocytes, tissue mast cells of the guinea-pig and rat intestinal mast cells were also unresponsive. Both drugs inhibited immunological histamine release from human pulmonary mast cells obtained by bronchoalveolar lavage (BAL) and, less effectively, from lung parenchyma. Nedocromil sodium was about 1 order of magnitude more potent than sodium cromoglycate in each case. Tachyphylaxis was observed with the dispersed lung, but not with the cells obtained by BAL, and the degree of inhibition varied inversely with the magnitude of the secretory response. The possible clinical significance of these observations is discussed.
Pearce
F L
FL
Department of Chemistry, University College London, United Kingdom.
Al-Laith
M
M
Bosman
L
L
Brostoff
J
J
Cunniffe
T M
TM
Flint
K C
KC
Hudspith
B N
BN
Jaffar
Z H
ZH
Johnson
N M
NM
Kassessinoff
T A
TA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D006224:Cricetinae; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000166:cytology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D008647:Mesocricetus; D051379:Mice; D017835:Nedocromil; D009559:Nippostrongylus / Q000276:immunology; D010537:Peritoneum / Q000166:cytology; D015363:Quinolones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015363:Quinolones; D017835:Nedocromil; D004205:Cromolyn Sodium