Dextran concentrations in plasma and urine following administration of 6% dextran-70/7.5% NaCl to hemorrhaged and euvolemic conscious swine.
Dextran metabolism was investigated in ten hemorrhaged and seven euvolemic conscious swine. Chronically instrumented, splenectomized swine were subjected to a progressive fixed-volume hemorrhage (27 ml/kg over 45 min). Resuscitation with 4 ml/kg of a 7.5% NaCl/6% dextran 70 (HSD) solution was begun 5 min later. Blood and urine samples were drawn before and during hemorrhage, and at 15, 60, and 120 min following intravenous HSD infusion. Hemorrhage significantly reduced cardiac output (CO) and mean arterial pressure (MAP) and eliminated urinary flow. HSD administration to hemorrhaged pigs returned CO and MAP to control values and improved urinary flow. Creatinine clearance returned to prehemorrhage values. These parameters were not affected by HSD in nonhemorrhaged animals. Plasma dextran concentrations were 20-30% higher in hemorrhaged pigs compared with euvolemic swine. In additional studies, plasma t1/2 for dextran was 9.4 hr in hemorrhaged pigs (n = 3) compared to 10.8 hr in euvolemic animals (n = 2). These data show that HSD ameliorates the effects of hemorrhage on cardiovascular and renal function and suggest that plasma clearance of dextran may be affected by hemorrhage.
Dubick
M A
MA
Division of Military Trauma Research, Letterman Army institute of Research, Presidio of San Francisco 94129-6800.
Summary
J J
JJ
Ryan
B A
BA
Wade
C E
CE
D000818:Animals; D003404:Creatinine / Q000652:urine; D003911:Dextrans / Q000097:blood* / Q000652:urine; D006801:Humans; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D013552:Swine
D003911:Dextrans; D012462:Saline Solution, Hypertonic; D003404:Creatinine