Neuropeptides in the middle ear mucosa.
Substance P- and neuropeptide Y-like immunoreactivity was demonstrated by immunohistochemical methods in mucosal specimens from the middle ear cleft of the guinea pig and rat. Substance P-like immunoreactivity was seen in corresponding specimens of the rabbit. Substance P-like immunoreactivity was also demonstrated in the tympanic nerve of various animal species and man. These specimens also showed weak immunoreactivity for bombesin. The findings suggest the presence of substance P in the tympanic nerve. Theoretically substance P may act in the middle ear cleft mucosa in several ways. One possibility is its putative role in the neurochemical control of the middle ear aeration. Another hypothetical possibility is a role in the neurogenic inflammation after noxious stimulation of the middle ear mucosa.
Ylikoski
J
J
Department of Anatomy, University of Helsinki, Finland.
Panula
P
P
D000328:Adult; D000818:Animals; D001839:Bombesin / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000032:analysis* / Q000294:innervation / Q000503:physiopathology; D006168:Guinea Pigs; D006801:Humans; D007150:Immunohistochemistry; D009092:Mucous Membrane / Q000032:analysis / Q000503:physiopathology; D009474:Neurons / Q000032:analysis / Q000502:physiology; D009478:Neuropeptide Y / Q000032:analysis*; D010033:Otitis Media / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D013373:Substance P / Q000032:analysis* / Q000502:physiology
D009478:Neuropeptide Y; D013373:Substance P; D001839:Bombesin