PAF-induced histamine release in the isolated perfused rat kidney.
The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. In this work we studied the effects of bolus injections of PAF on the isolated perfused rat kidney. Results showed histological damage at the proximal-tubule level and a significant histamine release.
Alessandrì
M G
MG
Institute of Pharmacology, Medical School, University of Pisa, Italy.
Giovannini
L
L
Mian
M
M
Palla
R
R
Gattai
V
V
Ciangherotti
A
A
Bertelli
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008297:Male; D010477:Perfusion; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010972:Platelet Activating Factor