title: Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.
abstract: We have studied the antigen specificity and processing requirements of three vaccine-induced cloned human T cell lines specific for HBsAg, the envelope protein of hepatitis B virus. Each T cell line recognized endogenously expressed antigen as well as exogenous antigen. Two clones required endosomal processing, both for exogenous and endogenous antigen; while the other T cell line depended on nonendosomal processing to generate antigenic peptides from both endogenous and exogenous antigen. Thus, the two processing pathways are accessible to exogenous and endogenous antigen. These results suggest that vaccine-induced T cells can participate actively in the immune response to live virus.
authors: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892.
authors: Y
authors: Y
authors: Jin
authors: W K
authors: WK
authors: Shih
authors: I
authors: I
authors: Berkower
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D002738:Chloroquine / Q000494:pharmacology; D002999:Clone Cells / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009940:Organoids / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D006514:Hepatitis B Surface Antigens; D014614:Vaccines, Synthetic; D002738:Chloroquine