Prevention of experimental coronary thrombosis by hirudin.
The antithrombotic activity of hirudin was studied in a rat coronary thrombosis model. The thrombus formation was induced by external application of silver nitrate solution onto the left anterior descending coronary artery. Following subcutaneous injection, hirudin in doses of 0.25, 0.5 and 1.0 mg/kg reduced the development of coronary thrombosis in a dose-dependent manner. The most pronounced antithrombotic effect of hirudin in the described model was related with plasma concentrations between 0.20 and 0.35 microgram hirudin/ml.
Bucha
E
E
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
Nowak
G
G
Markwardt
F
F
D000818:Animals; D003327:Coronary Disease / Q000473:pathology / Q000517:prevention & control*; D003328:Coronary Thrombosis / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000097:blood; D006629:Hirudins / Q000008:administration & dosage* / Q000097:blood; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005343:Fibrinolytic Agents; D006629:Hirudins