title: Monoclonal antibodies against components of the classical pathway of complement.
abstract: Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far which recognize either conserved epitopes or activation-dependent epitopes with particular emphasis on neoepitopes occurring during the activation cascade.
authors: Institute of Medical Microbiology, Johannes Gutenberg University, Mainz, FRG.
authors: H P
authors: HP
authors: Heinz
authors: M
authors: M
authors: Loos
mesh_terms: D000911:Antibodies, Monoclonal; D003166:Complement Activating Enzymes / Q000276:immunology; D003167:Complement Activation; D003172:Complement C1 / Q000276:immunology*; D015922:Complement C1q; D003175:Complement C2 / Q000276:immunology; D050577:Complement C3-C5 Convertases; D003181:Complement C4 / Q000276:immunology; D003171:Complement Pathway, Classical; D003165:Complement System Proteins / Q000276:immunology*; D000939:Epitopes / Q000276:immunology* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D003172:Complement C1; D003175:Complement C2; D003181:Complement C4; D000939:Epitopes; D015922:Complement C1q; D003165:Complement System Proteins; D003166:Complement Activating Enzymes; D050577:Complement C3-C5 Convertases