Induction of experimental allergic neuritis with synthetic peptides from myelin P2 protein.
P2 protein and 4 synthetic peptides were tested for induction of experimental allergic neuritis (EAN). A peptide comprising the residues 62-78 of the bovine P2 protein sequence has been shown to contain an important neuritogenic determinant. A peptide comprising residues 66-78 produced no clinical symptoms of EAN. These results indicate that some or all of the residues 62 65 (Ile-Ser-Phe-Lys), are necessary for EAN induction.
Shin
H C
HC
School of Chemistry, University of Sydney, NSW, Australia.
McFarlane
E F
EF
Pollard
J D
JD
Watson
E G
EG
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000494:pharmacology*; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000139:chemically induced*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew
D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D010446:Peptide Fragments