[The use of immune RNA (i-RNA) to prevent and treat burn infection].
The immune RNA was extracted from the spleens and livers of immunizing sheep with Ps. aeruginosa, E. coli and S. aureus. After animal trial, the i-RNA activity and its antibacterial protective effect has been demonstrated. 95 cases of burn infection treated with i-RNA plus antibiotics were compared with a concurrent control group treated with antibiotics alone. Clinical observation confirmed that an obvious effect on the prevention and treatment of burn infection with gram negative bacteria was manifested. Among them, 59 cases with burn area 15-49% II degrees, III degrees of total body surface, the ratio of incidence of gram negative septicemia and wound pyemia between i-RNA and control group was 1.69%: 22%, p less than 0.01. In another 36 cases with burn area over 50% body surface II degrees, III degrees treated with i-RNA the gram negative septicemia or wound sepsis were found in 3 cases (morbidity 8.3%). And one died overall mortality was 2.8%. Whereas, the morbidity and mortality were 51.4% and 45.9% respectively in 37 control cases. The ratio of morbidity between i-RNA and control group was 8.3%: 51.4%, p less than 0.01, and that of mortality was 2.8%: 45.9%, p less than 0.01.
Han
F Y
FY
D002056:Burns / Q000150:complications*; D006801:Humans; D012313:RNA / Q000276:immunology* / Q000627:therapeutic use; D014946:Wound Infection / Q000517:prevention & control* / Q000628:therapy
C013674:RNA, immune; D012313:RNA