1,4-naphthoquinone-2-sulfonic acid derivatives coupled to dextran as carriers for interferon.
Three derivatives of 1,4-naphthoquinone-2-sulfonic acid possessing the fragments of Cibacron Blue (CB) were synthesized and bound to Dextran T 2000 by ether binding. Polymers IVD, VD and VID were incubated with interferon (IFN) to obtain complexes: carrier-IFN. It was found that polymer VID has weaker affinity to mouse IFN-beta/alpha and to human IFN-beta than Blue Dextran. The polymers IVD and VD had no affinity to the interferon.
Piasecki
E
E
Laboratory of Tumor Virology, Polish Academy of Sciences, Wrocław.
Charytonowicz
D
D
Konieczny
M
M
Inglot
A D
AD
D000345:Affinity Labels; D000818:Animals; D003116:Color; D003911:Dextrans; D004337:Drug Carriers; D006801:Humans; D007372:Interferons; D051379:Mice; D015394:Molecular Structure; D009285:Naphthoquinones; D011108:Polymers
D000345:Affinity Labels; D003911:Dextrans; D004337:Drug Carriers; D009285:Naphthoquinones; D011108:Polymers; D007372:Interferons