Pituitary dependence of bone marrow function.
The anaemia, leucopenia, thrombocytopenia and impaired DNA and RNA synthesis in the bone marrow of hypophysectomized rats could be restored by syngeneic pituitary grafts placed under the kidney capsule, or by treatments with ovine or bovine prolactin or growth hormone. Treatment with ACTH, FSH, LH and TSH had no effect in this respect. These results indicate that bone marrow function is regulated by the pituitary gland.
Nagy
E
E
Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Berczi
I
I
D000740:Anemia / Q000503:physiopathology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000503:physiopathology*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006402:Hematologic Diseases / Q000503:physiopathology*; D006728:Hormones / Q000494:pharmacology; D007016:Hypophysectomy; D007970:Leukopenia / Q000503:physiopathology; D010902:Pituitary Gland / Q000502:physiology* / Q000637:transplantation; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011916:Rats, Inbred F344; D013921:Thrombocytopenia / Q000503:physiopathology; D014185:Transplantation, Isogeneic
D006728:Hormones; D012313:RNA; D004247:DNA