Effects of cisplatin and bleomycin on mature rat Leydig cell testosterone production.
A single i.p. injection of either cisplatin or bleomycin affects the testosterone production by the Leydig cells in mature rats. It is noteworthy that on day 30 after treatment, a complete recovery of Leydig cell function is found in bleomycin-treated rats whereas in cisplatin-injected animals, 25-48% decreases of testosterone synthesis are still observed, respectively, under basal and LH-stimulated conditions. Together with the germ cell destruction, the low testosterone levels probably contribute to the sterility in cisplatin-treated rats.
Carreau
S
S
Laboratoire de Biochimie, UA CNRS 609, CHU Côte de Nacre, Caen, France.
Papadopoulos
V
V
Boujrad
N
N
Drosdowsky
M A
MA
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood
D001761:Bleomycin; D013739:Testosterone; D002945:Cisplatin