Salvage of relapsed malignant histiocytosis by autologous bone marrow transplant.
A 21-year-old female presenting with malignant histiocytosis was initially treated with conventional aggressive chemotherapy resulting in complete remission (CR) but relapsed within 6 months of discontinuation. The patient was reinduced with two cycles of cis-platinum, cytosine arabinoside and mitoxantrone and achieved CR, at which time she received single agent high-dose melphalan followed by autologous bone marrow transplant. She remains in CR 36 months after the autograft procedure.
Berry
J
J
Department of Medicine, Tom Baker Cancer Center, Calgary, Alberta, Canada.
Russell
J A
JA
D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D008942:Mitoxantrone / Q000008:administration & dosage; D012074:Remission Induction; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage
D003561:Cytarabine; D001761:Bleomycin; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D008942:Mitoxantrone; D002945:Cisplatin; D002955:Leucovorin; D008727:Methotrexate