[Pathohistologic studies of serial sections of squamous cell cancer of the oral cavity and oropharynx following cytostatic induction therapy with bleomycin and cisplatin].
43 patients with advanced squamous cell carcinoma of the oral cavity and oropharynx were treated preoperatively by a combined chemotherapy with bleomycin and cisplatinum. After surgery histological serial sections of resection specimens were examined. In no case did the tumour tissues show a complete response. After induction chemotherapy 35 patients had histologically partial response - shrinkage by more than 50%. In these cases histological evaluation revealed tumour areas with pseudocysts containing on the one hand necrotic material and showing keratinisation on the other. A tumour was also found histologically under regrown epithelium in 10 cases where complete tumour remission was postulated clinically. Eight patients showed histologically a minor response - shrinkage below 50% with only little necrotic areas. Exophytic tumours responded better to chemotherapy than endophytic tumours. Endophytic tumours showed small isolated tumour areas in the periphery of the infiltrated tissues.
Bettinger
R
R
Zentrum der Hals-nasen-Ohrenheilkunde, Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
Meyer-Breiting
E
E
Klima
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009336:Necrosis; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009960:Oropharynx / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000188:drug therapy*; D012074:Remission Induction
D001761:Bleomycin; D002945:Cisplatin
Pathohistologische Serienschnittuntersuchungen bei Plattenepithelkarzinomen der Mundhöhle und des oropharynx nach zytostatischer Induktionstherapie mit Bleomycin und cis-platin.