[Influence of actinomycin D on the effectiveness of producing ts mutants of the Japanese encephalitis virus].
Reciprocal competition of viral and cellular matrices of RNA synthesis was demonstrated, as well as a 10-13-fold increase of 3H-uridine incorporation into viral RNAs in the presence of actinomycin D, the inhibiting effect of actinomycin D on virus replication, the dependence of the late stage of Japanese encephalitis virus reproduction upon the host cell, and no positive effect of actinomycin D on generation of Japanese encephalitis virus ts mutants.
Tikhomirov
E E
EE
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004664:Encephalitis Virus, Japanese / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D005472:Fluorouracil / Q000494:pharmacology; D009154:Mutation; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects; D012367:RNA, Viral / Q000096:biosynthesis / Q000187:drug effects; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D012367:RNA, Viral; D014316:Tritium; D003609:Dactinomycin; D012313:RNA; D005472:Fluorouracil; D014529:Uridine
Vliianie aktinomitsina D na éffektivnost' polucheniia ts-mutantov virusa iaponskogo éntsefalita.