Activation of human plasminogen by streptokinase: new aspects of fibrinolysis regulation.
It is established fact, that SK-initiated fibrinolysis is decelerated, when oxygen is removed from solutions; that SK possesses superoxide dismutase-like activity and that its activating function is sharply inhibited by superoxide radical scavengers. The point in discussion is the possibility of oxygen-dependent Pg activation, which is not related to functions of serine proteinase-like activators. The realization of oxygen-radical mechanisms is supposed to depend on activation of zymogens of other serine proteinases and proteinase reactions effect.
Nikandrov
V N
VN
Laboratory of Biochemistry and Technology of Microbial Enzymes, Byelorussian Research Institute of Epidemiology and Microbiology, Minsk, USSR.
Pyzhova
N S
NS
D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D010100:Oxygen / Q000494:pharmacology; D013300:Streptokinase / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D013482:Superoxide Dismutase; D013300:Streptokinase; D010100:Oxygen