Selective attention in Alzheimer's disease: CSF correlates of behavioral impairments.
CSF levels of HVA, 5-HIAA, and free MHPG, the major metabolites of dopamine, serotonin, and norepinephrine respectively, were measured in 22 patients with AD. These 22 patients were also administered tests of picture-recognition and attentional focusing as part of an earlier experiment. A significant association between deficits in attentional focusing and reduced levels of free MHPG in CSF was noted. These results suggest that behavioral measures can identify patients with noradrenergic involvement.
Freed
D M
DM
Department of Psychology and Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139.
Corkin
S
S
Growdon
J H
JH
Nissen
M J
MJ
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000523:psychology; D001288:Attention / Q000502:physiology*; D005260:Female; D006018:Glycols / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D009483:Neuropsychological Tests
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid