title: C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin.
abstract: Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.
authors: Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts 02115.
authors: S M
authors: SM
authors: Rybak
authors: D S
authors: DS
authors: Auld
authors: D K
authors: DK
authors: St Clair
authors: Q Z
authors: QZ
authors: Yao
authors: J W
authors: JW
authors: Fett
mesh_terms: D000595:Amino Acid Sequence; D043925:Angiogenesis Inducing Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D006224:Cricetinae; D006131:Growth Inhibitors; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D011500:Protein Synthesis Inhibitors / Q000037:antagonists & inhibitors; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000378:metabolism; D012259:Ribonuclease, Pancreatic; D013379:Substrate Specificity
chemical_list: D043925:Angiogenesis Inducing Agents; D006131:Growth Inhibitors; D010446:Peptide Fragments; D011500:Protein Synthesis Inhibitors; D011506:Proteins; D012313:RNA; C046366:angiogenin; D012259:Ribonuclease, Pancreatic