Circulating perivascular dilatory neuropeptides in hypertension.
Little is known about perivascular neuropeptides in hypertension in man. In this study we investigated the circulating levels of calcitonin gene-related peptide (CGRP)-, substance P- and vasoactive intestinal peptide-like immunoreactivity in 30 patients with severe hypertension before and after treatment for high blood pressure. Circulating levels of CGRP- and substance P-like immunoreactivity in the hypertensives were significantly different from the corresponding levels in 31 age- and sex-matched normotensive subjects. After normalization of blood pressure the mean levels of CGRP- and substance P-like immunoreactivity did not differ between the two groups. The levels of vasoactive intestinal peptide-like immunoreactivity remained unchanged. These observations suggest that vascular afferent nerves play a part in the maintenance of hypertension.
Edvinsson
L
L
Department of Internal Medicine, University Hospital, Lund, Sweden.
Ekman
R
R
Thulin
T
T
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D013373:Substance P / Q000097:blood; D014660:Vasoactive Intestinal Peptide / Q000097:blood; D014664:Vasodilation / Q000502:physiology*
D000959:Antihypertensive Agents; D009479:Neuropeptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide