title: Effect of verapamil on platelet aggregation.
abstract: The influence of the calcium channel blocker verapamil on the aggregation of human blood platelets was studied in vitro in comparison with the calcium channel blocker diltiazem and with the 5-HT antagonist cyproheptadine. Verapamil inhibited the 5-HT-potentiated. ADP-induced aggregation more effectively than the aggregation induced by adrenaline, ADP and collagen. Verapamil antagonized the 5-HT effect in a noncompetitive manner. The same was true of cyprohepatadine which was by more than one order of magnitude more potent than verapamil in inhibiting the 5-HT-induced aggregation. Diltiazem was much less effective than verapamil.
authors: Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
authors: E
authors: E
authors: Glusa
mesh_terms: D000244:Adenosine Diphosphate / Q000502:physiology; D003094:Collagen / Q000502:physiology; D003533:Cyproheptadine / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004837:Epinephrine / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D003533:Cyproheptadine; D012701:Serotonin; D000244:Adenosine Diphosphate; D003094:Collagen; D014700:Verapamil; D004110:Diltiazem; D004837:Epinephrine