title: One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.
abstract: The Substance P fragment Arg1-Pro2-Lys3-Pro4 (SP1-4) has been extensively investigated by means of proton nuclear magnetic resonance at 400 MHz. The combined application of different 2D techniques and a comparison of SP1-4 with its derivative SP1-4-amide allowed the complete and unambiguous assignment of the proton NMR spectrum. Conformational data obtained from the different NMR parameters are compared with theoretical calculations. The results suggest that SP1-4 exists, at the chosen experimental conditions, as a stretched molecule.
authors: Department of Chemistry, University of Alberta, Edmonton, Canada.
authors: A
authors: A
authors: Otter
authors: G
authors: G
authors: Kotovych
authors: J M
authors: JM
authors: Stewart
mesh_terms: D000595:Amino Acid Sequence; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments; D011487:Protein Conformation; D013373:Substance P
chemical_list: D010446:Peptide Fragments; D013373:Substance P; C042612:substance P (1-4)