An animal study of different treatments to prevent postoperative pelvic adhesions.
A study was designed to test various high-molecular-weight solutions in the prevention of postoperative intraabdominal adhesions. The bicornuate rat uterus was used as the surgical model, and 80 mature white female rats underwent surgical injury of the right uterine horn. The rats were randomly divided into 5 groups: groups A, B, and C received 5 ml intraperitoneally of chondroitin sulfate, sodium carboxymethylcellulose, and 32% dextran 70, respectively; group D was treated with microsurgical repair; and group E, the control, received no therapy. The animals were killed postoperatively, and the adhesions were scored. Significantly better results in adhesion prevention were demonstrated in the sodium carboxymethylcellulose group vs. the other groups, except in group A where the difference was not significant.
Graebe
R A
RA
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Oelsner
G
G
Cornelison
T L
TL
Pan
S B
SB
Haseltine
F P
FP
DeCherney
A H
AH
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D008747:Methylcellulose / Q000031:analogs & derivatives*; D010388:Pelvis; D051381:Rats; D000267:Tissue Adhesions / Q000517:prevention & control; D014599:Uterus / Q000601:surgery*
D003911:Dextrans; D008747:Methylcellulose; D002807:Chondroitin; D002809:Chondroitin Sulfates; D002266:Carboxymethylcellulose Sodium