A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.
Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.
Nadeau
J H
JH
Jackson Laboratory, Bar Harbor, Maine 04609.
Berger
F G
FG
Cox
D R
DR
Crosby
J L
JL
Davisson
M T
MT
Ferrara
D
D
Fuchs
E
E
Hart
C
C
Hunihan
L
L
Lalley
P A
PA
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002875:Chromosomes; D006224:Cricetinae; D003433:Crosses, Genetic; D005260:Female; D005801:Genes, Homeobox; D008040:Genetic Linkage; D006822:Hybrid Cells; D007633:Keratins / Q000235:genetics*; D008297:Male; D051379:Mice; D005810:Multigene Family; D009154:Mutation; D051381:Rats; D011995:Recombination, Genetic
D007633:Keratins