Galanin suppresses neurally evoked contractions of circular muscle in the guinea-pig ileum.
The effect of galanin, a 29 amino-acid peptide, on intestinal smooth muscles was studied in guinea-pig ileum. Galanin did not affect the basal activity of longitudinal or circular muscles. Galanin decreased neurally evoked circular muscle contractions in a dose-dependent manner, but failed to affect neurally evoked longitudinal muscle contractions. Galanin also decreased neurally evoked circular muscle contractions in the presence of atropine. The neurally evoked phasic contractions were blocked by TTX. These findings indicate that galanin has an inhibitory role in circular muscle contractions via myenteric neurons in the guinea-pig ileum.
Kuwahara
A
A
Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Ozaki
T
T
Yanaihara
N
N
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D019004:Galanin; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology
D000700:Analgesics; D010455:Peptides; D013373:Substance P; D019004:Galanin; C042867:spantide