[Detection of the degree of activity of ulcerative colitis. Behavior of serum alpha 1-proteinase inhibitor and alpha 2-macroglobulin].
The study of two proteins, acute phase reactants, alpha 1-proteinase inhibitor and alpha 2-macroglobulin, has demonstrated their utility in the diagnosis of the activity of ulcerative colitis. Alpha 1-proteinase inhibitor presented serum increases parallel to the degree of activity, permitting differentiation of asymptomatic, mild, moderate and severe phases of the disease. Increases in alpha 2-macroglobulin coincided with less-intense phases of the disease. The possible biological basis of this different behavior is discussed, as well as its potential inclusion among the biological tests currently used in clinical practice.
Amiguet
J A
JA
Sagüés
J
J
Muñoz
M A
MA
Zozaya
J
J
Conchillo
F
F
D000209:Acute-Phase Proteins / Q000097:blood*; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000502:physiology*; D003093:Colitis, Ulcerative / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000097:blood*; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins / Q000502:physiology*
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins
Detección del grado de actividad de la colitis ulcerosa. Comportamiento de alfa 1-proteinasa inhibidor y alfa 2-macroglobulina séricas.