The influence of substance P on oviductal, duodenal and blood pressure in the anaesthetized domestic hen.
In 13 anaesthetized hens in the peak phase of their first laying year the influence of intravenously injected substance P (SP), 1-10 micrograms/animal, on oviductal pressure, duodenal pressure, blood pressure and heart rate has been studied within 5 h of oviposition. The neuropeptide induced a significant pressure increase in the different segments of the oviduct (infundibulum, magnum, isthmus, uterus and vagina) as well as in the duodenum. Blood pressure revealed a distinct biphasic response: a short period of hypotension accompanied by a tachycardia and a more pronounced and sustained hypertension, inducing a subsequent bradycardia. The complexity of the observed effects demonstrates the overall impact of intravenously administered SP on the anaesthetized hen.
De Saedeleer
V
V
Laboratory of Veterinary Physiology, University of Antwerp, State University Centre, Belgium.
Wechsung
E
E
Houvenaghel
A
A
D000704:Analysis of Variance; D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D010057:Oviducts / Q000187:drug effects* / Q000502:physiology; D011312:Pressure; D012044:Regression Analysis; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P