Reaction of a tumour-associated trypsin inhibitor with serine proteinases associated with coagulation and tumour invasion.
The inhibition of six serine proteinases by a tumour-associated trypsin inhibitor (TATI) was studied using synthetic peptide substrates. Physiological concentrations of TATI inhibited the amidolytic activities of trypsin, plasmin, urokinase and tissue plasminogen activator (tPA). Chymotrypsin, kallikrein and thrombin were also inhibited, but by much higher concentrations of TATI. The ability of TATI to inhibit trypsin, plasmin, urokinase and tPA suggests that it has a role in proteolytic processes in vivo involving these enzymes.
Turpeinen
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U
Department I of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Koivunen
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E
Stenman
U H
UH
D007611:Aprotinin / Q000494:pharmacology; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors; D046911:Macromolecular Substances; D009361:Neoplasm Invasiveness; D015842:Serine Proteinase Inhibitors; D013917:Thrombin / Q000037:antagonists & inhibitors; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000494:pharmacology*; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors
D046911:Macromolecular Substances; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic; D007611:Aprotinin; D014360:Trypsin Inhibitor, Kunitz Soybean; D007610:Kallikreins; D002918:Chymotrypsin; D013917:Thrombin; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator