Binding of 3H-spiperone to human peripheral lymphocytes: absence of stereospecific high-affinity binding.
The binding of 3H-spiperone to human peripheral lymphocytes (PBL) was characterized. The (+)-butaclamol displaceable binding of 3H-spiperone was not saturable, and both (+) and (-)-butaclamol were equally potent in displacing 3H-spiperone binding. We did not find evidence for the existence of a high-affinity specific binding site of 3H-spiperone on human PBL.
Feenstra
A
A
Neuropsychiatry Branch, National Institute of Mental Health Neurosciences Center, Washington, DC 20032.
Coggiano
M A
MA
Wyatt
R J
RJ
D001667:Binding, Competitive; D002069:Butaclamol / Q000493:pharmacokinetics; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D011869:Radioligand Assay; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000493:pharmacokinetics*
D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D013134:Spiperone; D002069:Butaclamol