Placental protein distribution in maternal diabetes mellitus: an immunocytochemical study.
Placentas associated with maternal diabetes are generally characterized by features of villous immaturity. We correlated the villous histology with the immunocytochemical distribution of four trophoblastic proteins: beta human chorionic gonadotropin (beta HCG), placental alkaline phosphatase (PLAP), pregnancy specific beta-1-glycoprotein (SP1), and human placental lactogen (HPL) in 14 third-trimester placentas associated with diabetes mellitus. Staining was increased for beta HCG and decreased for PLAP, SP1, and HPL in the diabetic placentas compared to control placentas of similar gestational age. This pattern was most prominent in areas of marked architectural villous immaturity within individual placentas and suggests concomitant functional immaturity.
Greco
M A
MA
Department of Pathology, New York University School of Medicine, New York 10016.
Kamat
B R
BR
Demopoulos
R I
RI
D000469:Alkaline Phosphatase / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002824:Chorionic Villi / Q000378:metabolism* / Q000473:pathology; D004200:Diseases in Twins; D005260:Female; D005313:Fetal Death / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D010926:Placental Hormones / Q000378:metabolism*; D010928:Placental Lactogen / Q000378:metabolism; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism* / Q000473:pathology; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D010926:Placental Hormones; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen; D000469:Alkaline Phosphatase