Influence of iloprost on eicosanoid generation and lipid levels in experimental myocardial ischemia in dogs.
Anaesthetized mongrel dogs were subjected to occlusion of a coronary artery. The resulting myocardial infarction was observed for three hours. One hour after occlusion, infusion of the stable prostacyclin analogue iloprost or saline was started. In the control group myocardial infarction was associated with an increase of the ratio TXB2/6-keto-PGF1a which was abolished by iloprost treatment. After occlusion in the control group, the atherosclerosis index (TC-HDLC): HDLC was increased, but in the iloprost-treated group it was significantly decreased. The results of this study suggest that the administration of iloprost is able to prevent changes in eicosanoid metabolism and lipoprotein pattern after coronary artery occlusion in dogs.
Beitz
A
A
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
Taube
C
C
Beitz
J
J
Goos
H
H
Graff
J
J
Nöhring
J
J
Lindenau
K F
KF
Mest
H J
HJ
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D003327:Coronary Disease / Q000097:blood*; D004285:Dogs; D004537:Eicosanoic Acids / Q000097:blood / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D016285:Iloprost; D008055:Lipids / Q000097:blood*; D008297:Male; D011466:Prostanoic Acids / Q000096:biosynthesis / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D004537:Eicosanoic Acids; D008055:Lipids; D011466:Prostanoic Acids; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D016285:Iloprost