title: Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat.
abstract: Acute as well as chronic treatment with ketanserin but not with ritanserin reduced the blood pressure in the spontaneously hypertensive rat, indicating that 5-HT2-receptor blockade alone does not have antihypertensive properties. Whereas the blood pressure reduction to acute administration of ketanserin was directly related to its ability to shift the dose-response curve of phenylephrine (alpha 1-adrenergic blockade), the same relationship was not apparent following chronic treatment with ketanserin. This suggests that the 5-HT2- and alpha 1-blockade may complement each other in reducing the blood pressure, a conclusion supported by the observation that in the conscious rat, 5-HT2-receptor blockade by ritanserin enhanced the hypotensive response to prazosin. However, ritanserin did not influence the ability of prazosin to antagonize pressor responses to phenylephrine in the pithed rat.
authors: Department of Pharmacology, University of Göteborg, Sweden.
authors: B
authors: B
authors: Persson
authors: K
authors: K
authors: Gradin
authors: A
authors: A
authors: Pettersson
authors: T
authors: T
authors: Hedner
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D010880:Piperidines / Q000627:therapeutic use*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D016713:Ritanserin; D012701:Serotonin / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D010880:Piperidines; D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D016713:Ritanserin; D010656:Phenylephrine; D012701:Serotonin; D007650:Ketanserin; D011224:Prazosin