The inhibitor of F VIIa in plasma measured with a sensitive chromogenic substrate assay: comparison with antithrombin, protein C and heparin cofactor II in a clinical material.
The plasma inhibitor(s) of factor VIIa-tissue thromboplastin cooperates with factor Xa. This "Extrinsic Pathway Inhibitor" has been quantitated with a sensitive chromogenic substrate assay. Gel filtration of plasma separates 3 EPI peaks. Postoperatively, both EPI and the other coagulation inhibitors decrease. Unlike the other inhibitors, EPI is usually normal in severe liver cirrhosis. In disseminated intravascular coagulation, EPI levels vary considerably.
Abildgaard
U
U
Haematological Research Laboratory, Aker Hospital, Oslo, Norway.
Sandset
P M
PM
Andersson
T R
TR
Odegaard
O R
OR
Rosĕn
S
S
D000991:Antithrombins / Q000032:analysis*; D015415:Biomarkers; D002850:Chromatography, Gel; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005167:Factor VII / Q000037:antagonists & inhibitors*; D015942:Factor VIIa; D006023:Glycoproteins / Q000032:analysis*; D015844:Heparin Cofactor II; D006801:Humans; D011014:Pneumonia / Q000097:blood; D011486:Protein C / Q000032:analysis*
D000991:Antithrombins; D015415:Biomarkers; D006023:Glycoproteins; D011486:Protein C; D015844:Heparin Cofactor II; D005167:Factor VII; D015942:Factor VIIa