[Antigenic properties of synthetic fragments of the heavy chain of influenza virus A hemagglutinin].
The antigenic properties of the synthetic peptides corresponding to the regions 122-133, 136-147, 154-164 of the virus A/Aichi/2/68 hemagglutinin heavy chain have been studied. The 122-133 and 136-147 peptides comprise together almost whole antigenic determinant A, while the 154-164 peptide is a part of determinant B. Rabbits immunized by the peptides conjugated with carrier-protein BSA gave the high immune response to hapten-peptides. Each antiserum reacted only with homologous conjugate. All the antipeptide serums reacted with the virus A/Aichi/2/68 fixed on the base. Conjugate of the 136-147 peptide reacted with the rabbit antiserum against the virus A/Aichi/2/68 rendering the direct evidence to location of at least one hemagglutinin antigenic determinant in the region 136-147.
Samukov
V V
VV
Mazurkova
N A
NA
Kalashnikov
V V
VV
Ofitserov
V I
VI
Shval'e
A F
AF
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002642:Chick Embryo; D000939:Epitopes / Q000032:analysis*; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D010455:Peptides
Antigennye svoĭstva sinteticheskikh fragmentov tiazheloĭ tsepi gemaggliutinina virusa grippa A.