[Histamine distribution in the uterine structures of ovariectomized rats administered estradiol, histamine antagonists and an inhibitor of prostaglandin synthesis].
In the experiments performed on ovariectomized rats, using luminescent-histochemical method for revealing histamine after Cross, Ewen and Rost, it has been demonstrated that estradiol facilitates increasing histamine content in the uterine structures, as well as its redistribution--histamine content increases in the glandular and tegmental epithelia, in stromal cells, smooth myocytes and it decreases in macrophages. These manifestations of estradiol action are absent after cymetidin and indometacin, but not tavegil administration. The first two inhibit the morphological effect of estradiol in the uterus, indometacin making it in a greater degree. It is supposed that estradiol action, concerning provision of the uterine structures with histamine, takes place together with prostaglandins participation and at hormonal activation of H2-receptors. Taking into account the literature data on stimulating influence of estradiol on macrophagal phagocytosis and secretion, a conclusion is made that decreasing content of histamine in macrophages at estrogenization results from histamine release by these cells; macrophages are potential sources of histamine in the uterus.
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D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D002974:Clemastine / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006651:Histocytochemistry; D007213:Indomethacin / Q000494:pharmacology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D011448:Prostaglandin Antagonists; D004958:Estradiol; D002927:Cimetidine; D006632:Histamine; D002974:Clemastine; D007213:Indomethacin
Raspredelenie gistamina v strukturakh matki ovariéktomirovannykh krys pri vvedenii éstradiola, antagonistov gistamina i ingibitora sinteza prostaglandinov.