[Effect of the N-terminal fragment of substance P1-4 on the somatic manifestations of the stress reaction and on the catecholamine content of the adrenals in rats].
The antistress affect of the substance P1-4 N-terminal fragment (ARG-Pro-Lys-Pro, 100 mkg/kg, i.p.) has been studied on the model of immobilization stress in rats. It was ascertained that the preparation of protective effect is revealed to the greatest extent on the exhaustion stage (48 h of immobilization), which served to prevent the lymphoid organs mass reduction and ulcer development and also accounted for greater adrenaline and noradrenaline content preservation in tissues and chromaffin cells of adrenal glands in stressed animals.
Arefolov
V A
VA
Malikova
L A
LA
Val'dman
A V
AV
Nieber
K
K
Oehme
P
P
D000311:Adrenal Glands / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D002395:Catecholamines / Q000032:analysis / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013373:Substance P / Q000627:therapeutic use*; D013997:Time Factors
D002395:Catecholamines; D010446:Peptide Fragments; D013373:Substance P; C042612:substance P (1-4)
Vliianie N-terminal'nogo fragmenta substantsii P1-4 na somaticheskie proiavleniia stressovoĭ reaktsii i soderzhanie katekholaminov v nadpochechnikakh krys.