title: Signet-ring squamous cell carcinoma.
abstract: Among carcinomas, signet-ring morphologic characteristics have been regarded as pathognomonic of adenocarcinoma. This report presents the case of a poorly differentiated cutaneous squamous cell carcinoma with a monodispersed, invasive signet-ring component. Kreyberg stains had negative results for mucin. Immunohistochemical analysis demonstrated that concentric rings in the signet-ring cells were composed of keratin. To the best of the authors' knowledge, this is the first report of signet-ring squamous cell carcinoma. Another feature that bears emphasis is that this squamous cell carcinoma led to the death of the patient, even though it originated in a field of actinic keratosis.
authors: Department of Pathology, Rochester General Hospital, New York 14621.
authors: S F
authors: SF
authors: Cramer
authors: L M
authors: LM
authors: Heggeness
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005546:Forehead; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007636:Keratoacanthoma / Q000473:pathology; D007642:Keratosis / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D013194:Staining and Labeling
chemical_list: D007633:Keratins