Suloctidil increases the rat brain cortex microvascular regeneration after a lesion.
A "cavity" lesion made by aspiration in the rat occipital cortex induces a parenchymal and a vascular reaction in its vicinity. The first was mainly characterized by cellular necrosis and gliosis, the second by an increase of the vascular network. In vehicle treated rats, a 50% significant increase of the vascular network was observed around the cavity 4 days after the lesion, in comparison to the uninjured contralateral cortex. The effects of a vasoactive substance, suloctidil, on the vascular reaction was studied in the brain cortex. A single oral dose of suloctidil (30 mg/kg; 2 hours before the sacrifice) gave the same effect as the vehicle group. After 8 days of suloctidil oral administration (30 mg/kg; twice daily: 4 days before lesion and 4 days after) a significant increase (123%) of the vascular network was observed around the cavity. The hypothetical ways by which a chronic treatment of suloctidil induces this increase of the neovascularization observed after cortical lesion are discussed.
De Paermentier
F
F
Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Belgium.
Heuschling
P
P
Knoops
B
B
Janssens De Varebeke
P
P
Pauwels
G
G
Laszlo De Kaszon-Jakabfalva
C
C
Van den Bosch De Aguilar
P
P
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000503:physiopathology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D013396:Suction; D013468:Suloctidil / Q000494:pharmacology*; D014144:Tragacanth
D011412:Propanolamines; D014144:Tragacanth; D013468:Suloctidil