[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus].
Plasmids have been constructed which contain genes coding for fused proteins including beta-galactosidase or human leukocyte interferon alpha 2 and monomeric or pentameric form of the main antigenic determinant of the foot-and-mouth disease virus (FMDV) serotype 01K. Expression of the hybrid genes has been studied. It is shown that fused proteins, containing beta-galactosidase and the antigenic determinant (monomer or pentamer), interact specifically with anti-FMDV anti-sera and with antibodies against peptide 141-160 of FMDV VP1 coat protein.
Chernen'kaia
E A
EA
Gurevich
A I
AI
Korobko
V G
VG
D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D004274:DNA, Recombinant; D000939:Epitopes / Q000235:genetics*; D007370:Interferon Type I / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids; D011993:Recombinant Fusion Proteins / Q000235:genetics; D001616:beta-Galactosidase / Q000235:genetics
D004274:DNA, Recombinant; D000939:Epitopes; D007370:Interferon Type I; D011993:Recombinant Fusion Proteins; D001616:beta-Galactosidase
Rekombinantnye plazmidy, soderzhashchie geny gibridnykh belkov s antigennoĭ determinantoĭ virusa iashchura.