title: Procarbazine hypersensitivity manifested as a fixed drug eruption.
abstract: A case of a previously unrecognized form of hypersensitivity to procarbazine characterized by a nonpigmented fixed drug eruption is reported. Despite skin testing, association of the skin lesion to procarbazine could be determined only by drug rechallenge. Various aspects of procarbazine hypersensitivity reactions as well as the pathogenesis and importance of the fixed drug eruption are discussed.
authors: Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307.
authors: J K
authors: JK
authors: Giguere
authors: D M
authors: DM
authors: Douglas
authors: G P
authors: GP
authors: Lupton
authors: J R
authors: JR
authors: Baker
authors: R B
authors: RB
authors: Weiss
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects*; D012882:Skin Tests; D014747:Vinblastine; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D011241:Prednisone