title: Hemodynamic effects of knee-joint tamponade. 99mTc-diphosphonate scintimetry in growing dogs.
abstract: We studied the influence of joint effusion on juxtaarticular vascularity and bone metabolism of the immature knee in puppies by dynamic and static 99mTc-diphosphonate scintimetry. Unilateral joint tamponade of 10 KPa (75 mmHg), introduced by intraarticular dextran-70 infusion, resulted in quantitatively similar scintimetric changes in an angiographic Phase I (0-20 sec), a blood pool Phase II (20-256 sec), and a bone-uptake Phase III (2 h). The uptake was reduced by 20 percent in the distal femoral epiphysis, by 15 percent in the distal femoral growth plate in Phases II-III, and by 8 percent in the proximal tibial growth plate in Phase III. The main part of scintimetric changes during joint tamponade could be ascribed to altered epiphyseal and metaphyseal intraosseous hemodynamics.
authors: Arhus Orthopedic Hospital, Denmark.
authors: E S
authors: ES
authors: Hansen
authors: T B
authors: TB
authors: Henriksen
authors: I
authors: I
authors: Noer
authors: C
authors: C
authors: Bünger
mesh_terms: D000818:Animals; D003911:Dextrans; D004164:Diphosphonates; D004285:Dogs; D005122:Exudates and Transudates / Q000502:physiology*; D006132:Growth Plate / Q000000981:diagnostic imaging / Q000378:metabolism; D006439:Hemodynamics; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011312:Pressure; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D013667:Technetium; D017556:Technetium Compounds
chemical_list: D003911:Dextrans; D004164:Diphosphonates; D017556:Technetium Compounds; D013667:Technetium; C029045:technetium Tc 99m diphosphonate