Secondary structure prediction for RNA binding domain in RNP proteins identifies beta alpha beta as the main structural motif.
In eukaryotic cells transcript processing is strictly dependent upon binding of specific proteins. Nuclear RNA binding proteins share a common domain, which is involved in RNA binding. In order to characterize RNP-RNA interactions we have performed a secondary structure prediction based both on statistical algorithms and comparative analysis of different proteins. A high conservation for secondary structure propensity between different RNPs was observed.
Ghetti
A
A
Istituto di Scienze Biologiche, Università di Verona, Italy.
Padovani
C
C
Di Cesare
G
G
Morandi
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D006801:Humans; D006860:Hydrogen Bonding; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012313:RNA / Q000378:metabolism; D012261:Ribonucleoproteins / Q000648:ultrastructure
D012261:Ribonucleoproteins; D012313:RNA