Laparoscopically applied fibrin glue in experimental liver trauma.
We have investigated the feasibility of applying fibrin glue to liver injuries using laparoscopic guidance and have examined the gross and microscopic changes that occurred in hepatic lacerations treated with fibrin glue. These studies indicate that fibrin glue may be effectively applied to liver injuries using laparoscopic control, hepatic bleeding may be rapidly controlled when fibrin glue is applied into the base of the wound, there is no gross or microscopic evidence of hepatic toxicity related to the use of fibrin glue, and healing of liver lacerations treated by fibrin glue occurs by ingrowth of granulation tissue coupled with fibrinolysis of the fibrin glue.
Ishitani
M B
MB
Department of Surgery, University of Virginia School of Medicine, Charlottesville 22908.
McGahren
E D
ED
Sibley
D A
DA
Spotnitz
W D
WD
Rodgers
B M
BM
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006470:Hemorrhage / Q000517:prevention & control*; D010535:Laparoscopy; D008099:Liver / Q000293:injuries* / Q000473:pathology; D013552:Swine; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin