Characteristic sequences in the upstream region of the human tyrosinase gene.
A human tyrosinase gene containing a 5'-flanking region and the first exon was isolated from a normal human liver library using mouse tyrosinase cDNA as a probe for screening. In the 5'-upstream region of transcriptional start sites, there is a putative TATA box and CAAT box and some palindromic sequences. A characteristic sequence of (GA:TCn, which can assume a hinged-DNA structure, was present from -869 nt to -633 nt in this 5'-flanking region.
Kikuchi
H
H
Department of Cancer Chemotherapy and Prevention, Research Institute for Tuberculosis and Cancer, Sendai, Japan.
Miura
H
H
Yamamoto
H
H
Takeuchi
T
T
Dei
T
T
Watanabe
M
M
D000417:Albinism / Q000235:genetics*; D001483:Base Sequence; D015139:Blotting, Southern; D004156:Catechol Oxidase / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data; D014442:Monophenol Monooxygenase / Q000235:genetics*; D005810:Multigene Family; D012313:RNA / Q000032:analysis; D014158:Transcription, Genetic
D015342:DNA Probes; D012313:RNA; D004247:DNA; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase