Effects of tachykinins on mucus secretion in human bronchi in vitro.
We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.
Rogers
D F
DF
Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
Aursudkij
B
B
Barnes
P J
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism; D015288:Neurokinin A / Q000494:pharmacology; D015287:Neurokinin B / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology*; D015320:Tachykinins / Q000494:pharmacology*
D006020:Glycopeptides; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B; D015260:Neprilysin; C008890:phosphoramidon