title: Effect of FK-506, a novel immunosuppressive drug on murine systemic lupus erythematosus.
abstract: A novel immunosuppressive compound extracted from the fermentation broth of Streptomyces tsukubaensis belongs to the macrolide family. We gave this drug (FK-506) to MRL/lpr and NZB X NZW F1 (B/W F1) mice, an animal model of human systemic lupus erythematosus (SLE), to investigate its effect on the course of the disease. This drug showed potential to prolong the lifespan, to reduce proteinuria, and to prevent the progression of nephropathy. Appreciable differences in the levels of anti-dsDNA antibodies between treated and control animals were nil.
authors: Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors: K
authors: K
authors: Takabayashi
authors: T
authors: T
authors: Koike
authors: K
authors: K
authors: Kurasawa
authors: R
authors: R
authors: Matsumura
authors: T
authors: T
authors: Sato
authors: H
authors: H
authors: Tomioka
authors: I
authors: I
authors: Ito
authors: T
authors: T
authors: Yoshiki
authors: S
authors: S
authors: Yoshida
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D004247:DNA / Q000276:immunology; D007074:Immunoglobulin G / Q000145:classification; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008181:Lupus Nephritis / Q000188:drug therapy; D051379:Mice; D011507:Proteinuria / Q000188:drug therapy; D011725:Pyridines / Q000627:therapeutic use*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016559:Tacrolimus
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D011725:Pyridines; D004247:DNA; D016559:Tacrolimus