Pharmacokinetics of procainamide in continuous ambulatory peritoneal dialysis.
Procainamide (PA) and N-acetylprocainamide (NAPA) pharmacokinetics were examined in six patients undergoing continuous ambulatory peritoneal dialysis (CAPD) following a single oral dose of 625 mg of procainamide HCl. Peak serum PA concentrations occurred between 1 and 3 h after drug administration whereas peak NAPA levels were reached 14 to 48 h following the administration of PA. NAPA levels 1.2 mcg/ml or greater were present for 72 h and in four of the six subjects little further decline occurred at 96 h. PA total body clearance (TBC) averaged 143 ml/min; TBC for NAPA was 29.8 ml/min. PA and NAPA half-lives were considerably prolonged averaging 26.0 and 42.8 h, respectively. V beta for PA was 4.1 l/kg and for NAPA was 1.46 l/kg. PA and NAPA dialysance varied from 0.28 to 5.55 ml/min and from 1.74 to 7.20 ml/min, respectively. This, in turn, represented less than 5 and 25% of the TBC for each drug.
Sica
D A
DA
Department of Medicine, Medical College of Virginia, Richmond.
Yonce
C
C
Small
R
R
Cefali
E
E
Harford
A
A
Poynor
W
W
D000120:Acecainide / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011342:Procainamide / Q000097:blood / Q000493:pharmacokinetics*
D000120:Acecainide; D011342:Procainamide