Indoleamine stores in maturing mouse brain reexposed to citalopram following extended uptake inhibition.
1. Mice of various ages between birth and adulthood were injected daily for 5 days with the serotonin specific uptake inhibitor citalopram (LU 10-171). 2 days later they were reinjected with citalopram 2. 2 hr, 1 day and 3 days following the last injection animals were killed and their brains assayed for 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA). 3. Brains were found to still respond to citalopram's acute action despite the fact younger brains had undergone long term alteration of 5-HIAA stores. 4. The possibility that indoleamines are subject to different regulatory mechanisms in young brain is discussed.
Baker
P C
PC
Department of Biology, Cleveland State University, OH 44115.
Hoff
K M
KM
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000378:metabolism; D015283:Citalopram / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*
D007211:Indoles; D012702:Serotonin Antagonists; D015283:Citalopram; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid