Measles virus-specific human T cell clones: studies of alloreactivity and antigenic cross-reactivity.
Cross-reactivity between altered self and foreign major histocompatibility complex (MHC) may be of etiologic importance in autoimmune disease. We have studied 29 measles virus-specific cloned and uncloned T cell lines from a patient with multiple sclerosis (MS) and from a normal subject. Two of the T cell clones derived from the normal subject reacted with foreign MHC determinants. No cross-reactivity between measles virus and either myelin basic protein (BP) or galactocerebroside (GC) was detected. T cell clones which are specific for nominal antigen and which also recognize alloantigen were detected with much smaller frequency than that reported in murine systems. Our data do not support a role for alloreactive measles-specific T cells, nor for cross-reactivity between measles virus and either BP or GC, in the pathogenesis of MS.
Richert
J R
JR
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007.
Robinson
E D
ED
Reuben-Burnside
C A
CA
Johnson
A H
AH
McFarland
H F
HF
McFarlin
D E
DE
Hartzman
R J
RJ
D000956:Antigens, Viral / Q000276:immunology; D002999:Clone Cells; D003429:Cross Reactions; D005699:Galactosylceramides / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation; D008459:Measles virus / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D005699:Galactosylceramides; D006680:HLA Antigens; D007519:Isoantigens; D004676:Myelin Basic Protein