title: [Medical treatment of inoperable malignant glioma. Non-superselective intra-arterial chemotherapy with HECNU followed by conventional radiotherapy].
abstract: Forty-six cases of non-surgical malignant glioma were treated by several repeated infusion of non-superselective intra-arterial chemotherapy using HECNU, followed by conventional radiotherapy. Chemotherapy was well tolerated immediately. Good responses rate was 46% for the whole group, but was higher in anaplastic astrocytomas (71%) than in glioblastomas (43%). The median survival for responders was 17 months, and clinical improvement was observed in a large majority of them. Later, neurological or ophthalmological ipsilateral complications of varying severity were observed in 8.7% and 15% of the cases respectively. Despite these complications the treatment was generally well tolerated and gave in responders a longer survival with better comfort.
authors: Service de Neuroradiologie Charcot, La Salpêtrière, Paris.
authors: J
authors: J
authors: Chiras
authors: F
authors: F
authors: Fauchon
authors: M
authors: M
authors: Poisson
authors: C
authors: C
authors: Debussche
authors: L
authors: L
authors: Chauveinc
authors: Y
authors: Y
authors: Pereon
authors: R A
authors: RA
authors: Guérin
authors: J
authors: J
authors: Bories
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010166:Palliative Care
chemical_list: D009153:Mutagens; D009607:Nitrosourea Compounds; C013876:elmustine
vernacular_title: Traitement médical des gliomes malins inopérables. Chimiothérapie intra-artérielle non hypersélective par HECNU suivie de radiothérapie conventionnelle.