title: Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects.
abstract: Hemoglobin is widely used as an inhibitor of EDRF effects. Hemoglobin contracts pig coronary arteries in vitro. However, during this contraction, effects of substance P and bradykinin which act via the EDRF are not inhibited. This means that the hemoglobin contraction is not caused by inhibition of the EDRF. This contraction is caused by a substance released from the endothelium, and by eicosanoïds released from the smooth muscles.
authors: Département de Biologie Animale, Université de Genève, Switzerland.
authors: J L
authors: JL
authors: Bény
authors: P C
authors: PC
authors: Brunet
authors: V
authors: V
authors: Van der Bent
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors; D004730:Endothelium, Vascular / Q000502:physiology*; D006454:Hemoglobins / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008706:Methemoglobin / Q000494:pharmacology; D009569:Nitric Oxide; D010108:Oxyhemoglobins / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D001685:Biological Factors; D016861:Cyclooxygenase Inhibitors; D006454:Hemoglobins; D016859:Lipoxygenase Inhibitors; D010108:Oxyhemoglobins; D009569:Nitric Oxide; D013373:Substance P; D009637:Masoprocol; D008706:Methemoglobin; D001920:Bradykinin; D007213:Indomethacin