[Comparison of anti-influenza vaccines: whole adsorbed trivalent, trivalent subunit and tetravalent subunit].
Two different sub-unit polyvalent vaccines have been compared with the trivalent whole virus adsorbed vaccine, in two different groups of people, including both sexes, aging between 20 and 60 yrs. and between 65 and 85 yrs. respectively. Our findings show that all the three vaccines induced high seroconversion rates against the subtypes A/Mississippi/1/85 and A/Chile/1/83. As to the strain B/Ann Arbor/1/86 the sub-unit vaccine induced significantly higher seroconversion rates then the whole virus vaccine; the geometric mean titer has been higher in the groups given the vaccine than in the remaining group; in the latter group the GMTs of antibody against the A strains were consistently above the protective level, whereas the GMT of antibody against the B strain was fairly low. The authors consider useless including into the vaccine the strains A/Mississippi/1/85 and A/Chile/1/83, whereas it seems to be essential the incorporation of the strains A/Singapore/1/86 like and B/Ann Arbor/1/86. Moreover it turns out that the sub-unit vaccines, because of their better effectiveness, should substitute the whole virus adsorbed vaccine.
D'Errico
M M
MM
Istituto di Igiene e Medicina Preventiva, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.
Grasso
G M
GM
Romano
F
F
Montanaro
D
D
D000328:Adult; D004339:Drug Compounding; D004341:Drug Evaluation; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D009982:Gammainfluenzavirus / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000939:Epitopes; D007252:Influenza Vaccines
Confronto tra vaccini antinfluenzali trivalente intero adsorbito, trivalente subunità e tetravalente subunit.