Evidence for the lack of involvement of free radicals in adriamycin-induced histamine release from rat peritoneal cells.
The antineoplastic drug adriamycin, at a concentration of 100 micrograms/ml, caused a significant histamine release from rat peritoneal mast cells. This exocytotic process was unaffected by pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol and reduced glutathione. Only very high concentrations of n-acetylcysteine significantly limited this release; this substance was also active in limiting histamine secretion induced by a classic mast cell secretagogue, compound 48/80.
Candussio
L
L
Institute of Pharmacology, University of Trieste, Italy.
Bartoli Klugmann
F
F
Decorti
G
G
Baldini
L
L
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D004317:Doxorubicin / Q000494:pharmacology*; D005609:Free Radicals; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D004317:Doxorubicin; D000111:Acetylcysteine