Ten-year survival and late sequelae in testicular cancer patients treated with cisplatin, vinblastine, and bleomycin.
This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.
Stoter
G
G
Free University Hospital, Amsterdam, The Netherlands.
Koopman
A
A
Vendrik
C P
CP
Struyvenberg
A
A
Sleyfer
D T
DT
Willemse
P H
PH
Schraffordt Koops
H
H
van Oosterom
A T
AT
ten Bokkel Huinink
W W
WW
Pinedo
H M
HM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D004651:Employment; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010809:Physical Fitness; D011379:Prognosis; D011928:Raynaud Disease / Q000209:etiology; D012725:Sexual Behavior / Q000187:drug effects; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage*
D001761:Bleomycin; D014747:Vinblastine; D003404:Creatinine; D002945:Cisplatin