[Structural properties and lipid-binding characteristics of plasma fibrinogen and gamma-globulins in vitamin D-deficient rickets].
Structure properties and lipid-binding ability of fibrinogen and gamma-globulins were studied in blood plasma of children with rickets. Content of cholesterol and its esters, developing complexes with fibrinogen, was found to increase simultaneously with a decrease in the phospholipids, containing in the protein fraction, under conditions of the disease. Surface charge of the proteins studied, especially of fibrinogen, was altered, thus demonstrating the distinct impairments of their structure and functions. Lipid environment appears to be of importance in functional activity of these proteins.
Apukhovskaia
L I
LI
Antonenko
L V
LV
Kholodova
Iu D
IuD
Voziian
P A
PA
Solodova
E V
EV
D000596:Amino Acids / Q000032:analysis; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000097:blood*; D007223:Infant; D008055:Lipids / Q000097:blood*; D011485:Protein Binding; D005719:gamma-Globulins / Q000378:metabolism*
D000596:Amino Acids; D008055:Lipids; D005719:gamma-Globulins; D005340:Fibrinogen
Strukturnye osobennosti i lipidsviazyvaiushchaia sposobnost' fibrinogena i gamma-globulinov plazmy krovi pri vitamin-D-defitsitnom rakhite.