Potentiation by chlordecone of the defect in hepatic microsomal calcium sequestration induced by carbon tetrachloride.
The effect of carbon tetrachloride (CCl4) on the capacity of hepatic microsomes to sequester calcium was studied following pretreatment of rats with chlordecone. Chlordecone pretreatment alone had no effect on the kinetics of calcium uptake by hepatic microsomes. It was found, however, that chlordecone pretreatment of rats potentiated by sixfold the potency of CCl4 to suppress microsomal calcium sequestration capacity when measured one hour after CCl4 administration.
Hegarty
J M
JM
Department of Physiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Glende
E A
EA
Recknagel
R O
RO
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D007631:Chlordecone / Q000494:pharmacology*; D004357:Drug Synergism; D007306:Insecticides / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D002251:Carbon Tetrachloride; D007631:Chlordecone; D002118:Calcium