Interferon effects on osteoinduction.
Xenografts of human osteosarcoma growing in athymic mice are inhibited in growth rate by human interferon-alpha (IFN-alpha) treatment. In addition, differentiation of trabecular bone occurs external to the osteosarcomatous tissue and this is entirely dependent on IFN treatment. We have used species-specific anticollagens and antivimentin antibodies to determine the species origins of this trabecular bone. By using immunohistochemical procedures, it was found that this bone is host-derived. These results suggest that IFN provoked the production of a bone-inducing agent by the human osteosarcomas.
Triffitt
J T
JT
Nuffield Department of Orthopaedic Surgery, University of Oxford, UK.
Bauer
H C
HC
Brosjo
O
O
Joyner
C J
CJ
Forster
S
S
D000818:Animals; D003094:Collagen / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010012:Osteogenesis / Q000187:drug effects*; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology; D013045:Species Specificity; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D003094:Collagen; D007372:Interferons