[Megakaryocytes and thrombocytopoiesis in idiopathic thrombocytopenic purpura].
In idiopathic thrombocytopenic purpura (ITP) patients with histological signs of stronger auto-antibody synthesis (spleen follicle hyperplasia) more frequently revealed megakaryocyte changes due to antibodies and less frequently thrombocyte production compensatory increased than ITP patients with signs of weaker auto-antibody synthesis (spleen follicle normoplasia). The observation suggest that insufficient and frequently lacking compensatory increase of thrombocyte production in ITP is caused by an autoallergic disturbance of megakaryocyte maturation.
Arendt
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Institut für Pathologische Anatomie Wilhelm-Pieck-Universität Rostock.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001707:Biopsy, Needle; D001792:Blood Platelets / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies
Megakaryozyten und Thrombozytopoese bei der idiopathischen thrombozytopenischen Purpura.