[Antiviral activity of amiksin incorporated into liposomes].
The results of a comparative study of the antiviral activity of amyxin (tilorone) without liposomes and incorporated into liposomes on the model of experimental enteral hepatitis of mice are presented. The use of amyxin in liposomes was shown to prolong interferon production and to provide significant 60% protection of the animals. The possible mechanism of increasing the antiviral effectiveness of amyxin upon its incorporation into liposomes, enteral administration and subsequent enteral infection of mice with hepatitis virus is discussed. It is assumed that use of amyxin in liposomes may increase its effectiveness in prevention of human hepatitis A.
Grigorian
S S
SS
Simonov
A N
AN
Ivanova
A M
AM
Ershov
F I
FI
D000818:Animals; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005449:Fluorenes / Q000008:administration & dosage*; D006524:Hepatitis, Viral, Animal / Q000097:blood / Q000188:drug therapy; D007372:Interferons / Q000097:blood; D008081:Liposomes; D051379:Mice; D006517:Murine hepatitis virus; D013994:Tilorone / Q000008:administration & dosage* / Q000031:analogs & derivatives
D004337:Drug Carriers; D005449:Fluorenes; D008081:Liposomes; D007372:Interferons; D013994:Tilorone
Protivovirusnaia aktivnost' amiksina, zakliuchennogo v liposomy.