Studies into gastrinomas and combined carcinomatous carcinoid tumors. Optical light- and electron microscopy and immunohistochemistry.
The clinical, microscopic, immunohistochemical and ultrastructural features of 7 gastrinomas and 1 combined carcinoma-carcinoid tumor were evaluated. The tumors were located in the pancreas or duodenal wall in 6 cases, and on extragastro-enteropancreatic sites in 2 (liver or peripancreatic lymph node). All patients had the Zollinger-Ellison syndrome, 3 of them with additional bleeding and 1 with diarrhea. One patient with gastrinoma had additional tumors characteristic of the MEN-I syndrome. Immunohistochemistry showed gastrin and neuron-specific enolase-positivity in all of the tumors. Somatostatin was found in 4 cases, and single cell glucagon, pancreatic polypeptide. S-100 protein, keratin as well as carcino-embryonic antigen positivity in another few. Additional hormone production did not appear to be connected with biological behaviour of the tumors or with the clinical symptoms.
Lászik
Z
Z
Department of Pathology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Krenács
T
T
Baltás
B
B
Pap
A
A
Karácsony
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002276:Carcinoid Tumor / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D004379:Duodenal Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005755:Gastrins / Q000032:analysis; D005934:Glucagon / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D010191:Pancreatic Polypeptide / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013004:Somatostatin / Q000032:analysis; D015043:Zollinger-Ellison Syndrome / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D005755:Gastrins; D009418:S100 Proteins; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D007633:Keratins; D005934:Glucagon; D010751:Phosphopyruvate Hydratase