title: Intermediate filaments. Efficacy in surgical pathologic diagnosis.
abstract: The use of antibodies specific for the various types of intermediate filament proteins has become an important part of the immunohistochemical approach to surgical pathology. These proteins are expressed in a cell lineage-specific pattern, which is reproduced with great fidelity even in poorly differentiated neoplasms. The historic discovery, embryology, and structure of these proteins are reviewed. A brief discussion of the major applications and precautions in the choice and use of these antibodies is presented.
authors: Department of Pathology, University of Arizona, Tucson 85724.
authors: R B
authors: RB
authors: Nagle
mesh_terms: D000595:Amino Acid Sequence; D000906:Antibodies / Q000276:immunology; D002460:Cell Line; D003429:Cross Reactions; D003599:Cytoskeleton / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000235:genetics; D007382:Intermediate Filaments / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D007633:Keratins / Q000145:classification / Q000235:genetics; D009369:Neoplasms / Q000473:pathology / Q000648:ultrastructure
chemical_list: D000906:Antibodies; D007381:Intermediate Filament Proteins; D007633:Keratins