Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.
Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: (Formula: see text).
Dorsch
W
W
Pediatric Department Poliklinik, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
Wagner
H
H
Bayer
T
T
Fessler
B
B
Hein
G
G
Ring
J
J
Scheftner
P
P
Sieber
W
W
Strasser
T
T
Weiss
E
E
D000485:Allergens / Q000494:pharmacology; D000490:Allium / Q000032:analysis*; D000818:Animals; D001249:Asthma / Q000517:prevention & control; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D004347:Drug Interactions; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D015289:Leukotrienes / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D013441:Sulfinic Acids / Q000494:pharmacology*; D013931:Thromboxanes / Q000096:biosynthesis*
D000485:Allergens; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D010972:Platelet Activating Factor; D013441:Sulfinic Acids; D013931:Thromboxanes; C100040:thiosulfinic acids