Fibrin glue on the Cohn I fraction basis in repairing cerebral and dura defects--an experimental study on rats.
The rat skulls were operated upon using a trephine osteoplastically, and a defined cerebral and dura defect was induced. The repair of the cerebral defect was performed with Cohn I glue, or in combination with collageneous fleece. The dura defect was repaired by suture and/or glueing of a split skin or pedicle galeal-periostal flap. Thanks to using Cohn I glue, at all times sufficient venous hemostasis could be achieved, and in combination with collagen fleece the repair was at an optimum. The histological check-up demonstrated that neurotoxic side-effects were absent and there were no conglutinations with the dura. Suturing of the dura was highly time-consuming and impossible when the dura had been removed near the bone. The use of Cohn I adhesive permitted ready and defect repair commonly applicable. At high tension the combined suture-glueing technique proved to be superior.
Steube
D
D
Department of Neurosurgery, Medical Academy Erfurt, GDR.
Hamm
K D
KD
Pothe
H
H
Schreiber
D
D
Beer
R
R
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001798:Blood Proteins / Q000627:therapeutic use*; D001921:Brain / Q000601:surgery*; D004338:Drug Combinations / Q000627:therapeutic use; D004388:Dura Mater / Q000601:surgery*; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006470:Hemorrhage / Q000517:prevention & control; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D008866:Microsurgery; D010949:Plasma / Q000032:analysis*; D051381:Rats; D013537:Sutures; D013917:Thrombin / Q000627:therapeutic use*
D001798:Blood Proteins; C047487:Cohn fraction I; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin