title: Label distribution after injection of labelled tachykinins into the rat lateral cerebroventricle.
abstract: The present study investigated the label distribution in several brain regions, as well as in the peripheral circulation, following injection of labelled tachykinins [( 3H]-substance P, [3H]-eledoisin or [125I]-neurokinin A) into the lateral cerebroventricle of the rat. A widespread label distribution, extending as far as to the brainstem, was detected. Hypothalamus, striatum and hippocampus were the most labelled regions by the 3 labels; however the patterns of distribution of the 3 labelled tachykinins showed marked differences. Distribution in the brain was rapid, reaching a maximum usually within 2 min after injection and declining slightly afterwards. Large amounts of label (1/6-1/15 of the total amount injected) were detected in serum even at 2 min after injection and increased thereafter, reaching a maximum at 10-15 min.
authors: Department Farmaco-Biologico, School of Pharmacy, University of Messina, Italy.
authors: A
authors: A
authors: Saija
authors: C
authors: C
authors: Polidori
authors: M
authors: M
authors: Massi
authors: M
authors: M
authors: Perfumi
authors: G
authors: G
authors: De Caro
authors: G
authors: G
authors: Costa
mesh_terms: D000818:Animals; D004600:Eledoisin / Q000493:pharmacokinetics; D007276:Injections, Intraventricular; D007457:Iodine Radioisotopes; D008297:Male; D015288:Neurokinin A / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000493:pharmacokinetics; D015320:Tachykinins / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D007457:Iodine Radioisotopes; D015320:Tachykinins; D013373:Substance P; D004600:Eledoisin; D015288:Neurokinin A