The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.
Comparison of NH2-terminal protein sequence from the rat OX-44 antigen with the sequence of the human CD37 antigen deduced from a cDNA clone shows that these antigens are species homologues. The CD37 sequence is 244 amino acids in length and lacks a conventional leader sequence. The molecule is likely to have an NH2-terminal cytoplasmic domain followed by three transmembrane sequences that lie within the first 110 amino acids. The rest of the molecule is hydrophillic and contains three sites for N-linked glycosylation.
Classon
B J
BJ
Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
Williams
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AF
Willis
A C
AC
Seed
B
B
Stamenkovic
I
I
D000595:Amino Acid Sequence; D015703:Antigens, CD; D018951:Antigens, CD20; D000943:Antigens, Differentiation / Q000235:genetics*; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D000951:Antigens, Neoplasm; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics* / Q000648:ultrastructure*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D012995:Solubility; D060265:Tetraspanin 25; D059470:Tetraspanins
D015703:Antigens, CD; D018951:Antigens, CD20; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C059071:CD37 protein, human; C554894:CD53 protein, human; C554896:Cd53 protein, rat; D006023:Glycoproteins; D012333:RNA, Messenger; D060265:Tetraspanin 25; D059470:Tetraspanins; D004247:DNA