[The channel function of the hydrophobic fragment of Ca ATPase in the sarcoplasmic reticulum of rabbit skeletal muscles in the early period after x-ray radiation exposure].
At early times (1 and 24 h) following local single exposure of rabbit hindlimbs to 0.21 C/kg X-radiation Ca ATPase was isolated from sarcoplasmic reticulum of skeletal muscles and inserted in liposomes the treatment of which with trypsin resulted in the formation of proteoliposomes with a Ca ATPase hydrophobic fragment (Mr 45-50 kDa). It was shown that X-radiation increased the permeability of univalent and bivalent cations through a channel formed by the hydrophobic fragment of Ca ATPase and diminished ion selectivity of this channel.
Voĭtskiĭ
V M
VM
Fedorov
A N
AN
Kucherenko
N E
NE
Kurskiĭ
M D
MD
Khizhniak
S V
SV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000302:isolation & purification / Q000528:radiation effects*; D005260:Female; D007473:Ion Channels / Q000201:enzymology / Q000528:radiation effects*; D008081:Liposomes / Q000528:radiation effects; D008297:Male; D008564:Membrane Potentials / Q000528:radiation effects; D011510:Proteolipids / Q000528:radiation effects; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology / Q000528:radiation effects*; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology
D007473:Ion Channels; D008081:Liposomes; D011510:Proteolipids; C020485:proteoliposomes; D014357:Trypsin; D000252:Calcium-Transporting ATPases; D002118:Calcium
Kanal'naia funktsiia gidrofobnogo fragmenta Ca-ATFazy sarkoplazmaticheskogo retikuluma skeletnykh myshts krolika v ranniĭ period vozdeĭstviia rentgenovskim izlucheniem.