Expression of the 210 kDa neurofilament subunit in cultured central nervous system from normal and trisomy 16 mice: regulation by interferon.
When applied to central nervous system (CNS) cultures taken from normal fetal mice, interferon increases the immunohistochemical expression of the highly phosphorylated 210 kDa neurofilament subunit. This effect can be blocked by the application of an agent which inhibits interferon-mediated metabolic pathways. Murine trisomy 16 is an excellent model for human Down's Syndrome. CNS cultures taken from trisomy 16 fetal mice express greater intensity of 210 kDa neurofilament subunit immunohistochemical staining than do normals. Application of an interferon inhibitor normalizes trisomy 16 CNS neurofilament expression.
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Department of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
D000818:Animals; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism*; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007372:Interferons / Q000494:pharmacology*; D007382:Intermediate Filaments / Q000378:metabolism*; D007621:Karyotyping; D051379:Mice; D008970:Molecular Weight; D013687:Telencephalon / Q000166:cytology / Q000378:metabolism*
D007372:Interferons