Platelet-tumor cell interaction: effect of prostacyclin and a synthetic analog on metastasis formation.
The antimetastatic effect of the antithrombotic agents exogenous prostacyclin (PGI2) and a synthetic analog, Iloprost, on experimental metastasis formation was studied by injecting BL6 melanoma cells into C57BL/6 mice. Suitable in vivo treatment conditions were selected according to the known properties of the two drugs, including their pharmacokinetics. Iloprost showed a greater ability to inhibit platelet aggregation induced by BL6 melanoma cells. PGI2 displayed a limited antimetastatic activity, largely dependent on the tumor cell load and treatment schedule. Iloprost showed a far superior activity, its antimetastatic effect lasting longer and remaining detectable up to 6 h after tumor cell inoculation. The present data complex provides further support to the concept of a crucial role for platelet-tumor cell interaction in the process of metastasis formation.
Costantini
V
V
Istituto di Semeiotica Medica, Università di Perugia, Italy.
Fuschiotti
P
P
Allegrucci
M
M
Agnelli
G
G
Nenci
G G
GG
Fioretti
M C
MC
D000818:Animals; D002460:Cell Line; D011464:Epoprostenol / Q000494:pharmacology*; D016285:Iloprost; D008297:Male; D008545:Melanoma / Q000503:physiopathology* / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating; D010974:Platelet Aggregation / Q000187:drug effects*
D011464:Epoprostenol; D016285:Iloprost