Somatic antigens of Shigella: structure of the O-specific polysaccharide chain of the Shigella dysenteriae type 7 lipopolysaccharide.
4-(N-Acetylglycyl)amino-4,6-dideoxy-D-glucose has been identified as a component of the Shigella dysenteriae type 7 O-specific polysaccharide, in addition to the previously reported 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-galacturonic acid. On the basis of selective cleavage with anhydrous hydrogen fluoride and analysis by 1H- and 13C-n.m.r. spectroscopy and f.a.b.-mass spectrometry, it was concluded that the tetrasaccharide repeating-unit of the polysaccharide has the following structure: (structure; see text) where D-GalNAcAN is 2-acetamido-2-deoxy-D-galacturonamide and D-Qui4N is 4-amino-4,6-dideoxy-D-glucose.
Knirel
Y A
YA
N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the U.S.S.R., Moscow.
Dashunin
V V
VV
Shashkov
A S
AS
Kochetkov
N K
NK
Dmitriev
B A
BA
Hofman
I L
IL
D000942:Antigens, Bacterial / Q000032:analysis; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D008070:Lipopolysaccharides / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019081:O Antigens; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012762:Shigella dysenteriae / Q000276:immunology*
D000942:Antigens, Bacterial; D002241:Carbohydrates; D008070:Lipopolysaccharides; D019081:O Antigens