title: Capsaicin-sensitive nerves exert an inhibitory effect on the development of fibrin-induced pulmonary edema in rats.
abstract: This study was undertaken to evaluate the role of vagal nerves in the development of neurogenic pulmonary edema. We injected fibrinogen and thrombin into the cisterna magna of rats, a model of neurogenic pulmonary edema. When the vagal nerves were left intact, pulmonary edema occurred (fibrin-induced pulmonary edema) at a rate of 33%. Vagotomy at the midcervical portion increased the incidence of pulmonary edema to a rate of 100%, whereas pretreatment with atropine did not affect the incidence. These results suggested that vagal afferent nerves or nonadrenergic-noncholinergic efferent nerves played an important role in inhibiting the development of fibrin-induced pulmonary edema. Furthermore, in vagotomized and vagal nerve-intact rats pretreated with capsaicin, the incidence of pulmonary edema was 100%. Pretreatment with a substance P antagonist, [D-Pro2, D-Trp7,9]-SP, also increased the incidence to 100% in the vagal nerve-intact rats. On the other hand, intravenous administration of some neuropeptides that may be released from the capsaicin-sensitive nerves (e.g., substance P or calcitonin gene-related peptide) inhibited the development of pulmonary edema in vagotomized rats. We concluded that the vagal capsaicin-sensitive nerves exerted an inhibitory effect on the development of fibrin-induced pulmonary edema.
authors: Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors: Y
authors: Y
authors: Hashiba
authors: N
authors: N
authors: Ishikawa
authors: T
authors: T
authors: Sumita
authors: K
authors: K
authors: Takagi
authors: H
authors: H
authors: Hidaka
authors: T
authors: T
authors: Satake
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin / Q000494:pharmacology*; D005110:Extracellular Space / Q000378:metabolism; D005337:Fibrin; D006339:Heart Rate / Q000187:drug effects; D008168:Lung / Q000378:metabolism; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D009479:Neuropeptides; D013373:Substance P; C032132:substance P, prolyl(2)-tryptophan(7,9)-; D005337:Fibrin; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin