T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.
Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.
Dustin
M L
ML
Center for Blood Research, Boston, Massachusetts.
Springer
T A
TA
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology; D000943:Antigens, Differentiation / Q000502:physiology*; D003994:Bucladesine / Q000494:pharmacology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D005576:Colforsin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1; D008823:Micelles; D010703:Phorbol Esters / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D016028:Receptors, Leukocyte-Adhesion / Q000502:physiology*; D019311:Staurosporine; D013601:T-Lymphocytes / Q000502:physiology*; D013696:Temperature
D000470:Alkaloids; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D008823:Micelles; D010703:Phorbol Esters; D011948:Receptors, Antigen, T-Cell; D016028:Receptors, Leukocyte-Adhesion; D005576:Colforsin; D003994:Bucladesine; D019311:Staurosporine; D015056:1-Methyl-3-isobutylxanthine