title: Electroretinography in central retinal vein occlusion. Correlation of electroretinographic changes with pupillary abnormalities.
abstract: In 149 eyes with central retinal vein occlusion (CRVO), we prospectively investigated the role of routine, clinical electroretinography (ERG) in differentiating ischemic (60 eyes) from nonischemic CRVO (89 eyes). Single-flash photopic and scotopic ERGs were recorded. Data for the amplitudes and implicit times of a- and b-waves and for the b-/a-wave amplitude ratio were analyzed in detail. The study revealed that the best ERG parameter (for both photopic and scotopic ERG) for differentiating ischemic from nonischemic CRVO was a subnormal b-wave amplitude (reduced to less than or equal to 60% or by greater than or equal to 1 SD from the normal mean value, or less than or equal to 64%-69% of that in the fellow normal eye), with a sensitivity of 80%-90% and a specificity of 70%-80%. ERG findings were correlated with the relative afferent pupillary defect (RAPD). An RAPD of greater than or equal to 0.7 log units showed a sensitivity of 88% and a specificity of 90% in differentiating ischemic from nonischemic CRVO. ERG and RAPD findings showed a good correlation. The combined ERG and RAPD tests could differentiate 97%-100% of ischemic from nonischemic CRVO cases, with a specificity of about 70%.
authors: Department of Ophthalmology, University of Iowa, Iowa City 52242.
authors: S S
authors: SS
authors: Hayreh
authors: M R
authors: MR
authors: Klugman
authors: P
authors: P
authors: Podhajsky
authors: H E
authors: HE
authors: Kolder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004596:Electroretinography; D005123:Eye / Q000098:blood supply; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000175:diagnosis; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011681:Pupil Disorders / Q000175:diagnosis* / Q000503:physiopathology; D012044:Regression Analysis; D012170:Retinal Vein Occlusion / Q000145:classification / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology