Contrasting time course of catecholamine accumulation and of spontaneous discharge in experimental neuromas in the rat.
Catecholamine-containing sympathetic axons in rat sciatic nerve-end neuromas were visualized histochemically. Within a few hours of ligating and sectioning the nerve, axons began to accumulate catecholamine histofluorescence. Density of labelled fibers peaked 2-5 days postoperative, then declined rapidly so that little or no label was observed beyond 12 days. Sympathectomy eliminated staining; neonatal treatment with capsaicin had no effect. Accumulation and dissipation of histofluorescence preceded the rise and fall of electrical hyperexcitability in neuromas by several days respectively.
Goldstein
R S
RS
Department of Zoology, Hebrew University of Jerusalem, Israel.
Raber
P
P
Govrin-Lippmann
R
R
Devor
M
M
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology; D008297:Male; D009463:Neuroma / Q000473:pathology / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism*; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000473:pathology / Q000503:physiopathology*; D013563:Sympathectomy, Chemical
D009638:Norepinephrine