title: PAF-induced histamine release in the isolated perfused rat kidney.
abstract: The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. In this work we studied the effects of bolus injections of PAF on the isolated perfused rat kidney. Results showed histological damage at the proximal-tubule level and a significant histamine release.
authors: Institute of Pharmacology, Medical School, University of Pisa, Italy.
authors: M G
authors: MG
authors: Alessandrì
authors: L
authors: L
authors: Giovannini
authors: M
authors: M
authors: Mian
authors: R
authors: R
authors: Palla
authors: V
authors: V
authors: Gattai
authors: A
authors: A
authors: Ciangherotti
authors: A
authors: A
authors: Bertelli
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008297:Male; D010477:Perfusion; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D010972:Platelet Activating Factor