[Improvement of airway hyperreactivity in bronchial asthma patients with short disease duration treated with anti-allergic agents].
We treated bronchial asthma patients with anti-allergic agents for more than three months, and examined their effects on the airway hyperreactivity in 15 cases; five were short cases (disease duration was less than one year from the onset) and 10 were long cases (disease duration was more than one year). A significant improvement in airway hyperreactivity to histamine inhalation was observed in all five short cases. In 4 out of 5 short cases, the threshold of histamine concentration reached to the normal level of 10,000 micrograms/ml. On the other hand, the significant improvement was observed only in 2 out of 10 cases. We suggested that in "short asthma cases" the airway hyperreactivity could improve with the use of anti-allergic agents in a relatively short period and at a high rate.
Hoshino
K
K
Kawasaki
A
A
Mizushima
Y
Y
Yano
S
S
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001980:Bronchi / Q000276:immunology; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007665:Ketotifen / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010793:Phthalazines / Q000008:administration & dosage; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
D010793:Phthalazines; D062367:ortho-Aminobenzoates; D006632:Histamine; C012293:tranilast; D004205:Cromolyn Sodium; D007665:Ketotifen; C020976:azelastine