[The relationship between the intracellular content of 1-methyl-3-isobutylxanthine and the permeability for water of the bladder wall in the frog].
The data obtained show a direct interrelationship between the concentration of MIBX in cells and an increase of osmotic permeability. The method of determination of intracellular concentration of the MIBX using [3H]-MIBX, was developed, and the way to obtain radioactive MIBX described. The used approach permits to take into consideration functional changes as related to the intracellular concentration of inhibiting agents.
Natochin
Iu V
IuV
Parnova
R G
RG
Firsov
D L
DL
Shakhmatova
E I
EI
Kaminskiĭ
Iu L
IuL
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009995:Osmosis / Q000187:drug effects; D011896:Rana temporaria; D013806:Theophylline / Q000031:analogs & derivatives*; D014316:Tritium; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology*; D014867:Water / Q000378:metabolism*
D014867:Water; D014316:Tritium; D013806:Theophylline; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015056:1-Methyl-3-isobutylxanthine
Zavisimost' mezhdy vnutrikletochnym soderzhaniem 1-metil-3-izobutilksantina i pronitsaemost'iu dlia vody stenki mochevogo puzyria liagushki.