Post-transcriptional processing suggests that c-mos functions as a maternal message in mouse eggs.
Transcripts of the c-mos proto-oncogene were recently found to accumulate to high levels in mouse oocytes. We report here that the oocyte c-mos RNA is polyadenylated in concert with oocyte maturation, retained in mature ovulated eggs and zygotes but degraded by the late two cell embryo stage. These results suggest that c-mos functions as a maternal mRNA which is translated during oocyte maturation or fertilization and may play a role in these or other early developmental processes.
Goldman
D S
DS
Dana-Farber Cancer Institute, Boston, Massachusetts.
Kiessling
A A
AA
Cooper
G M
GM
D000818:Animals; D005260:Female; D008540:Meiosis; D051379:Mice; D009865:Oocytes / Q000378:metabolism*; D011061:Poly A / Q000378:metabolism; D011247:Pregnancy; D011519:Proto-Oncogenes; D012313:RNA / Q000032:analysis / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger
D012333:RNA, Messenger; D011061:Poly A; D012313:RNA