[The role of posterior capsule on diffusion of dextran from vitreous to the anterior chamber].
3H-dextran was injected into the vitreous cavity of rabbits, which had a phakic eye and an aphakic eye with the posterior capsule intact or incised. Aqueous humor was aspirated 60, 180, 360, 600, 960, or 1440 min. later and 3H-dextran was counted. The results were simulated with a two-compartment model. The diffusion constant from the vitreous body to the anterior chamber was the same both in aphakic eyes with intact posterior capsule and in phakic eyes, but it was twice as large in incised ones. The simulated initial vitreous concentration was less in phakic eyes and larger in incised one. These results suggest that the initial vitreous body concentration seems lower in phakic eyes. Aphakic eyes have more degenerated vitreous, so the aphakic eye with the intact posterior capsule have degenerated vitreous and incised one have more degenerated ones and diffuse more easily.
Nezu
N
N
D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism*; D003911:Dextrans / Q000493:pharmacokinetics*; D004058:Diffusion; D007903:Lens Capsule, Crystalline / Q000502:physiology* / Q000601:surgery; D007908:Lens, Crystalline / Q000502:physiology*; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism*
D003911:Dextrans