Regulation of experimental autoimmune encephalomyelitis. Specificity of the 'recovery-associated' suppressor cells.
We previously reported the presence of suppressor cells in Lewis rats at the very time of spontaneous recovery from experimental autoimmune encephalomyelitis. As these 'recovery-associated' suppressor cells might be implicated in the self-cure process, we investigated their specificity on the in vitro lymphoproliferative responses of a T cell line specific for myelin basic protein (MBP). We report now that these suppressor cells found in the thymus are specific for MBP, and not for T cell receptors, contrasting with the 'post-recovery' suppressor cell specificity reported by others. Furthermore, they do not recognize the encephalitogenic peptide 71-84, suggesting that their specificity involves an epitope outside (or partially out of) the encephalitogenic sequence.
Varriale
S
S
Laboratoire d'Immunopathologie, Faculté de Médecine, Marseille, France.
Béraud
E
E
Brandli
D
D
Barbaria
J
J
Golstein
M M
MM
Bernard
D
D
D000818:Animals; D000941:Antigens / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology; D000939:Epitopes; D005260:Female; D008213:Lymphocyte Activation; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012075:Remission, Spontaneous; D013154:Spleen / Q000473:pathology / Q000502:physiology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000473:pathology
D000941:Antigens; D000939:Epitopes; D004676:Myelin Basic Protein