[Norfloxacin concentration in human prostatic tissue after 3 days administration].
The penetration of norfloxacin into prostatic tissue was evaluated on 36 patients with benign prostatic hypertrophy. Norfloxacin was administered orally in a dose of 200 mg three times daily for 3 days preoperatively, blood samples were taken simultaneously at the time of tissue sampling. The patients were divided into 2 groups, groups 1 and 2. In group 1, tissue sampling was done after about 17 hours of final administration of the drug. The mean concentration of norfloxacin in prostatic tissue was 0.38 +/- 0.18 micrograms/g and 0.18 +/- 0.09 micrograms/ml in serum. In group 2, sampling was done after 5.5 hours of final administration. The mean concentration of norfloxacin in prostatic tissue was 0.89 +/- 0.32 micrograms/g and 0.49 +/- 0.25 micrograms/ml in serum.
Morita
M
M
Department of TUR, Sendai Social Insurance Hospital.
Hasuda
A
A
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism
D009643:Norfloxacin