[The functioning of the interferon system with different methods and dosages of recombinant alpha 2-interferon (reaferon) administration].
In clinical trials in 24 healthy volunteers of different doses of reaferon inoculated intramuscularly and intravenously for 3 days a pyrogenic reaction was observed the intensity of which depended upon the dose and route of inoculation. Reaferon exerted a dose-dependent effect on the recipient's interferon system: with large doses the interferon response of leukocytes and the capacity of lymphocytes for gamma-IF synthesis were markedly inhibited, whereas low doses (2 million IU/day) caused no significant changes. The intravenous inoculation of reaferon produced a relatively high but short-term, and the intramuscular inoculation a relatively low but of longer duration antiviral activity in the blood serum.
Malinovskaia
V V
VV
Murzabaeva
R T
RT
Manakhova
L S
LS
Mironova
L L
LL
D000293:Adolescent; D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007370:Interferon Type I / Q000008:administration & dosage* / Q000009:adverse effects; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007372:Interferons / Q000032:analysis*; D008297:Male; D011994:Recombinant Proteins; D013997:Time Factors
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007372:Interferons
Funktsionirovanie sistemy interferona pri razlichnykh sposobakh i dozakh vvedeniia rekombinantnogo al'fa 2-interferona (reaferona).