title: Liver cell carcinoma with orcein-positive granules and no identifiable copper.
abstract: A liver cell carcinoma removed surgically by partial hepatectomy from a 79-year-old woman contained abundant orcein-positive granules in many tumour cells. The granules were similar to those usually identified as representing copper-associated protein, yet they lacked copper, as demonstrated by negative rhodanine and rubeanic acid stains and energy dispersive X-ray microanalysis.
authors: Department of Histopathology, Charing Cross Hospital, London, UK.
authors: S
authors: S
authors: Shousha
authors: T B
authors: TB
authors: Bull
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000648:ultrastructure; D003300:Copper / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008668:Metallothionein / Q000378:metabolism; D010078:Oxazines; D013194:Staining and Labeling
chemical_list: D010078:Oxazines; C007121:copper thionein; C002313:PAcein; D003300:Copper; D008668:Metallothionein