Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13).
A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.
Noguera
R
R
Department of Pathology, Hospital Clinico, University of Valencia, Spain.
Llombart-Bosch
A
A
Lopez-Gines
C
C
Carda
C
C
Fernandez
C
C
D000328:Adult; D001859:Bone Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D005260:Female; D005870:Giant Cell Tumors / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology; D014178:Translocation, Genetic