[Increase in Leu7- Leu11+ cells in the peripheral blood lymphocytes of patients with alopecia areata].
Natural killer (NK) cell subsets in the peripheral blood lymphocytes of patients with alopecia areata (AA) were investigated by FACStar-I using NK cell specific monoclonal antibodies. The patients were classified into one of 2 types (Type A: single AA in regrowth phase; Type B: multiple AA, alopecia totalis and alopecia universalis in non-regrowth phase). The percentages of Leu7- Leu11+ cells in Type B were significantly higher than those of the normal control. The increase in Leu7- Leu11+ cells in Type B suggests that NK cells may play an important role in the pathogenesis of AA in the non-regrowth phase.
Imai
R
R
Miura
J
J
Takamori
K
K
D000328:Adult; D000506:Alopecia Areata / Q000097:blood / Q000276:immunology*; D000943:Antigens, Differentiation / Q000032:analysis*; D018959:CD57 Antigens; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG
D000943:Antigens, Differentiation; D018959:CD57 Antigens; D011961:Receptors, Fc; D017452:Receptors, IgG