Inhibitory effects of vincristine, ifosfamide and peplomycin on hormone-independent human prostatic carcinoma cell line.
The sensitivity of a hormone-independent human prostatic carcinoma cell line (PC-3) to anticancer drugs was evaluated in vitro. The anticancer drugs used were vincristine sulfate (VCR), peplomycin sulfate (PLM) and 4-hydroperoxyisophosphamide (4-HIF), i.e., an form of ifosfamide (IFOS) in vivo. The inhibitory effect of 4-HIF alone and of the combination of VCR, 4-HIF and PLM (VIP) on the cell proliferation was almost the same. Furthermore, among the 6 groups treated with 2 of the 3 drugs mentioned above the most potent inhibitory effect was obtained in the group with combined treatment of 4-HIF plus PLM.
Moriyama-Gonda
N
N
Department of Urology, Shimane Medical University, Izumo, Japan.
Mizutani
M
M
Ehara
S
S
Usui
T
T
Ishibe
T
T
D001761:Bleomycin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D007069:Ifosfamide / Q000494:pharmacology*; D008297:Male; D017663:Peplomycin; D011471:Prostatic Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D014750:Vincristine / Q000494:pharmacology*
D004338:Drug Combinations; D001761:Bleomycin; D017663:Peplomycin; D014750:Vincristine; D007069:Ifosfamide