Ultraviolet A inhibits histamine release from human peripheral leukocytes.
Irradiation of human peripheral leukocytes with ultraviolet A (UVA) induced a significant and dose-dependent reduction of anti-IgE or Ca-ionophore-stimulated histamine release without consistent influence upon C5a-induced release reactions. This effect was equally demonstrable in atopics and controls. In the presence of the radical scavenger superoxide dismutase, the UVA-induced inhibition of anti-IgE-induced histamine release was abolished. Under the conditions used, UVB exposure did not result in relevant changes of in vitro histamine release.
Ring
J
J
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, FRG.
Przybilla
B
B
Eberlein
B
B
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000937:Antigen-Antibody Reactions; D004307:Dose-Response Relationship, Radiation; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000528:radiation effects*; D013482:Superoxide Dismutase / Q000494:pharmacology; D014466:Ultraviolet Rays
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E; D013482:Superoxide Dismutase