Localized fibrous tumor (localized fibrous mesothelioma) of the liver.
A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83-year-old woman is presented. The tumor was 15 x 9 x 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high-power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1-3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow-up information has been limited.
Kottke-Marchant
K
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Department of Pathology, Cleveland Clinic Foundation, Ohio 44195.
Hart
W R
WR
Broughan
T
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D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000032:analysis; D003893:Desmin / Q000032:analysis; D051180:Desmoplakins; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis; D008654:Mesothelioma / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*; D008854:Microscopy, Electron; D018396:Mucin-1; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
D000951:Antigens, Neoplasm; D003598:Cytoskeletal Proteins; C495294:DSP protein, human; D003893:Desmin; D051180:Desmoplakins; D008562:Membrane Glycoproteins; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins