The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD2, CD3, CD4 and CD8 antigens in comparison to histocompatibility antigens of human lymphocytes.
The effects of alpha- and gamma-interferons (IFN-alpha, -gamma) and of interleukin 2 (IL-2) on the expression of certain differentiation antigens were compared with those of major histocompatibility antigens on human lymphocytes. IFN-gamma and IFN-alpha in high doses significantly increased the expression of T11 (CD2) differentiation antigen, but did not affect the expression of T4 (CD4), T8 (CD8), T3 (CD3) and Leu-7 antigens (HNK-1). Both natural and recombinant IFN-alpha and -beta apparently increased the expression of HLA-ABC antigens and of beta-2 microglobulin (beta 2m) after 16 h incubation. The amount of HLA-DR antigen, however, doubled in a few hours following IFN-gamma treatment. IL-2 affected the expression of CD2 and CD8 antigens only marginally, but did not affect that of CD3 and Leu-7; however, it strongly enhanced the expression of HLA-ABC, HLA-DR, and beta 2m antigens.
Kotlán
B
B
National Institute of Haematology and Blood Transfusion PF44, Budapest, Hungary.
Böck
G
G
Rajnavölgyi
E
E
Benczur
M
M
Mátyus
L
L
Gyódi
E
E
Huber
C
C
Petrányi
G G
GG
D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D006680:HLA Antigens; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis
D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D006680:HLA Antigens; D007370:Interferon Type I; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma; D007372:Interferons