[Reduction of 5-FU toxicity with improved nutritional status in tumor bearing mice].
This study was performed to determine the role of nutritional status as a determinants of 5 fluorouracil (5-FU) toxicity in a tumor bearing mice. After subcutaneous inoculation, of mammary tumor (81 B) mice were assigned randomly to two nutritional regimens, (1) 8% casein: D-mice, (2) 27% casein: N-mice. Mortality was increased significantly in D-mice (100%) compared with N-mice (0%) by administration of 5-FU (20 mg/kg). Intratumoral 5-FU concentration of D-mice was significantly lower than that of N-mice, 1 hour after i.p injection of 5-FU (100 mg/kg, 300 mg/kg). Both growth rate and intratumoral protein content of transplanted tumor was equivalent in two dietary group, N-mice and D-mice. Protein depleted status was associated with a significant reduction in Interferon production of spleen cells. Inhibition of cell proliferation in bone marrow and cytokine production were recognized in hypo-nutritional status. Thus, improved nutritional status reduced the morbidity and mortality associated with 5-FU treatment in tumor bearing mice.
Akimoto
M
M
Second Department of Surgery, Tohoku University, School of Medicine, Sendai.
Ohuchi
N
N
Matano
S
S
Hirakawa
H
H
Abe
M
M
Nishihira
T
T
Mori
S
S
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004044:Dietary Proteins / Q000008:administration & dosage; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D007372:Interferons / Q000096:biosynthesis; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009752:Nutritional Status; D011897:Random Allocation; D012039:Regional Blood Flow; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014018:Tissue Distribution
D004044:Dietary Proteins; D007372:Interferons; D005472:Fluorouracil