Monoclonal anti-Thy 1 antibody (OX7) is axonally transported in rat nervous system.
Monoclonal anti-Thy 1 antibody (OX7) was pressure microinjected into vagus nerve, tongue or caudate nucleus of rats. Indirect anti-IgG immunoperoxidase staining showed that OX7 was axonally transported antero- and/or retrogradely from all injection sites. Histological examination and behavioral observations did not reveal neurotoxicity from these single OX7 injections. We conclude OX7 may prove useful as a carrier for selectively targeting molecules at neurons via endocytosis and axonal transport.
LaRocca
C D
CD
Neurology Department, Vanderbilt University, Nashville, TN 37212.
Wiley
R G
RG
D000818:Animals; D000911:Antibodies, Monoclonal; D001370:Axonal Transport; D002421:Caudate Nucleus / Q000502:physiology*; D007518:Isoantibodies; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014059:Tongue / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*
D000911:Antibodies, Monoclonal; D007518:Isoantibodies; C035678:anti-Thy antibody