[Medullary carcinoma of the breast. Co-expression of keratin intermediate filaments and protein S-100 in tumor cells].
We have chosen 10 medullary carcinomas from a retrospective investigation on 450 cases of breast carcinoma (2.2%), according to the histomorphological criteria of Ridolfi and colleagues. By immunoperoxidase staining, we have evaluated the distribution of keratin and vimentin intermediate filaments, of CEA and S-100 protein in cancer cells. A widespread positivity to keratins has been proved in 70% of medullary carcinomas. Numerous neoplastic cells have coexpressed S-100 protein. We hypothesize the epithelial and myoepithelial "intermediate" differentiation of keratin and S-100 protein positive tumour cells.
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Lanzafame
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis* / Q000473:pathology; D003599:Cytoskeleton / Q000032:analysis*; D005260:Female; D006801:Humans; D007382:Intermediate Filaments / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis*; D014746:Vimentin / Q000032:analysis*
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins
Carcinoma midollare della mammella. Coespressione dei filamenti intermedi di cheratine e della proteina S-100 nelle cellule tumorali.