title: Synovial fluid lymphocytes in different subtypes of juvenile rheumatoid arthritis.
abstract: We studied the subsets of synovial fluid (SF) lymphocytes and their activation states in 4 subtypes of juvenile rheumatoid arthritis. The expression of lymphocyte differentiation antigens and activation markers (Ia and Tac) appeared to be similar in these subgroups. Tac + DNA-synthesizing T blasts represented, at most, 5% of all SF mononuclear cells. This finding was in clear contrast to the high proportion of Ia-positive SF mononuclear cells. There were no differences in Ia and Tac expression or DNA synthesis among the different juvenile rheumatoid arthritis subgroups. This finding suggests that the cell-mediated immune response may represent secondary features of the disease that are involved as a final common pathogenetic pathway.
authors: Fourth Department of Medicine, University of Helsinki, Finland.
authors: V
authors: V
authors: Bergroth
authors: Y T
authors: YT
authors: Konttinen
authors: P
authors: P
authors: Pelkonen
authors: M
authors: M
authors: Haapala
authors: J
authors: J
authors: Haapasaari
authors: D
authors: D
authors: Nordström
authors: I
authors: I
authors: Kunnamo
authors: C
authors: C
authors: Friman
mesh_terms: D001171:Arthritis, Juvenile / Q000145:classification / Q000473:pathology*; D000939:Epitopes; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D013582:Synovial Fluid / Q000166:cytology*
chemical_list: D000939:Epitopes