Superselective intra-arterial chemotherapy of advanced paranasal sinus tumors.
Twenty-four patients with advanced paranasal sinus tumors were treated with combined superselective intra-arterial and systemic chemotherapy, yielding an immediate satisfactory tumor response rate of 91%, significantly better than previously reported. Eight patients had craniofacial surgery circumvented because of complete or near complete response. Repetitive uncomplicated catheterization of the pterygoid segment of the internal maxillary artery using a coaxial system is the cornerstone of successful induction chemotherapy. Strenuous screening of medical status is mandatory for this aggressive introduction chemotherapy.
Lee
Y Y
YY
Department of Diagnostic Radiology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Dimery
I W
IW
Van Tassel
P
P
De Pena
C
C
Blacklock
J B
JB
Goepfert
H
H
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005005:Ethmoid Sinus; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008438:Maxillary Artery; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy*; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy*
D001761:Bleomycin; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil