title: Concerted gene duplications in the two keratin gene families.
abstract: Evolutionary trees were derived from the keratin protein sequences using the Phylogeny Analysis Using Parsimony (PAUP) set of programs. Three major unexpected conclusions were derived from the analysis: The smallest keratin protein subunit, K#19 (Moll et al. 1982), is not the most primitive one, but has evolved to fulfill a highly specialized function, presumably to redress the unbalanced synthesis of keratin subunits. Second, the ancestors of keratins expressed in the early embryonic stages, K#8 and K#18, were the first to diverge from the ancestors of all the other keratins. The branches leading to these two keratins are relatively short, indicating a comparatively strong selection against changes in the sequences of these two proteins. Third, the two keratin families show extraordinary parallelism in their patterns of gene duplications. In both families the genes expressed in embryos diverged first, later bursts of gene duplications created the subfamilies expressed in various differentiated cells, and relatively recent gene duplications gave rise to the hair keratin genes and separated the basal cell-specific keratin from those expressed under hyperproliferative conditions. The parallelism of gene duplications in the two keratin gene families implies a mechanism in which duplications in one family influence duplication events in the other family.
authors: Department of Dermatology, N.Y.U. Medical Center, New York 10016.
authors: M
authors: M
authors: Blumenberg
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005796:Genes; D006801:Humans; D007633:Keratins / Q000235:genetics*; D008957:Models, Genetic; D009928:Organ Specificity; D010802:Phylogeny; D013045:Species Specificity
chemical_list: D007633:Keratins