Nifedipine reversal of decreased serotonin metabolite levels during morphine withdrawal.
Morphine withdrawal induced by naloxone produced a significant decrease in serotonin turnover of guinea-pig brain. Nifedipine pretreatment markedly prevented this change induced by the abstinence syndrome. These data provide further evidence that nifedipine is effective in blocking the neurochemical expression of morphine abstinence.
Colado
M I
MI
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Lorenzo
P
P
Martín
M I
MI
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D006168:Guinea Pigs; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009021:Morphine Dependence / Q000139:chemically induced / Q000378:metabolism*; D009270:Naloxone; D009543:Nifedipine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D012701:Serotonin; D009270:Naloxone; D006897:Hydroxyindoleacetic Acid; D009543:Nifedipine