[Prostatic tissue levels of cefpiramide (CPM)].
The concentration of CPM in prostatic tissue and serum in 12 patients with benign prostatic hypertrophy was measured. One gram of CPM was injected intravenously prior to prostatectomy. One, 2, 3 and 5 hours following the administration of CPM, the mean serum level of CPM was 142, 88.2, 87.4 and 61.2 micrograms/ml, respectively, while the mean level in the prostatic tissue was 48.3, 15.1, 15.6 and 8.3 micrograms/g, respectively. The prostatic tissue level of CPM was thought to be enough to eradicate gram-negative and gram-positive bacteria in the prostate. It is presumed from our study that clinical effectiveness of CPM might be expected in the case of acute or chronic bacterial prostatitis.
Takata
K
K
Department of Urology, Iwate Prefectural Central Hospital.
Kawamura
S
S
Yoshida
I
I
D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011292:Premedication; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000601:surgery
D002511:Cephalosporins; C036666:cefpiramide