title: Brugia malayi microfilariae share epitopes with Aedes aegypti.
abstract: Shared antigens between Brugia malayi and Aedes aegypti were studied. The experiments carried out with sera from infected Mastomys natalensis indicated that an immunological response against A. aegypti antigens (Mr 185, 35, 32 kDa) appeared often when animals became microfilaraemic and increased progressively in intensity during the time-course of infection. Sera of animals immunized with B. malayi reacted with the crude extract of mosquitoes and conversely, antibodies from animals immunized with A. aegypti reacted with the surface of B. malayi microfilariae. The implications of these findings of the natural history of B. malayi infection are discussed.
authors: Unité Mixte INSERM U 167-CNRS 624, Institut Pasteur, Lille, France.
authors: M
authors: M
authors: Lastre
authors: J Y
authors: JY
authors: Cesbron
authors: O
authors: O
authors: Perez
authors: D
authors: D
authors: Henry
authors: A
authors: A
authors: Ouaissi
authors: C
authors: C
authors: Dissous
authors: A
authors: A
authors: Capron
mesh_terms: D000330:Aedes / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000032:analysis*; D000947:Antigens, Helminth / Q000032:analysis*; D002009:Brugia / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000032:analysis; D007106:Immune Sera / Q000276:immunology; D007303:Insect Vectors / Q000276:immunology*; D008842:Microfilariae / Q000276:immunology; D009115:Muridae; D011233:Precipitin Tests
chemical_list: D000941:Antigens; D000947:Antigens, Helminth; D000939:Epitopes; D007106:Immune Sera