title: Effect of repeated exposure to lindane and cadmium on lindane metabolism in rats.
abstract: The effects of daily administration of cadmium and lindane for 35 days on the metabolism of lindane in rats were investigated. The results indicate that cadmium induces a significant inhibition of lindane metabolism, since the group dosed with lindane plus cadmium had a significantly higher concentration of lindane in plasma and tissues than the group dosed with lindane alone. The inhibition in the metabolic rate of lindane is associated with the cadmium-induced alterations in the disposition of essential trace elements, Zn, Cu and Fe, in the liver.
authors: Industrial Toxicology Research Centre, Lucknow, India.
authors: R N
authors: RN
authors: Khanna
authors: M
authors: M
authors: Anand
authors: K
authors: K
authors: Gopal
authors: N
authors: N
authors: Varma
authors: G S
authors: GS
authors: Gupta
authors: P K
authors: PK
authors: Ray
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000378:metabolism; D004347:Drug Interactions; D001556:Hexachlorocyclohexane / Q000378:metabolism* / Q000633:toxicity; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D002104:Cadmium; D001556:Hexachlorocyclohexane; D003300:Copper; D007501:Iron; D015032:Zinc