The canine tail artery as a model for cerebral aneurysm studies.
The occluded canine tail artery, which comes off in the same plane as the aortoiliac junction, has been used as a flow model for cerebral aneurysms. These experiments were designed to determine if it is a realistic distensible model of human intracranial aneurysms. Distensibility studies were done on the aorta, and the iliac and tail arteries of four dogs. From these pressure-volume studies, tension-strain curves, elastances, and collagen slack were obtained. The tail artery is stiffer longitudinally and more distensible circumferentially than the other vessels. The iliac arteries and the aorta are not significantly different. The elastance of elastin and collagen is lower in the tail artery, and the collagen is more wavy circumferentially. Longitudinally, the collagen slack is least for the tail artery, and the elastance of elastin is not different in all three vessels. The number of elastin layers in the iliac and tail arteries seen in cross section is not significantly different, but the aorta is different from both these vessels. In another four dogs the aorta proximal to the trifurcation was cannulated and infused with saline to increase pressure. India ink marks were put on the surface to measure changes in length. Photographs were taken at intervals of 10 mmHg(1 mmHg = 133.3 Pa). This was done with the vessels tethered and untethered in the body and then taken out and studied with the same method in vitro. Arteries tethered in the body expanded circumferentially more than longitudinally. The tail artery becomes less distensible if untethered in the body and therefore acts more like an aneurysm.(ABSTRACT TRUNCATED AT 250 WORDS)
Boyce
T T
TT
Department of Medical Biophysics, University of Western Ontario, London, Canada.
Roach
M R
MR
D000818:Animals; D001011:Aorta / Q000502:physiology; D001158:Arteries / Q000032:analysis / Q000502:physiology*; D003094:Collagen / Q000032:analysis; D004195:Disease Models, Animal; D004285:Dogs; D004548:Elasticity; D004549:Elastin / Q000032:analysis; D007083:Iliac Artery / Q000502:physiology; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008855:Microscopy, Electron, Scanning; D012039:Regional Blood Flow; D013194:Staining and Labeling; D013623:Tail / Q000098:blood supply*
D003094:Collagen; D004549:Elastin