Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double immunocytochemically labeled materials.
The synaptic relationships between substance P-containing terminals and dopaminergic neurons (immunoreactive for tyrosine hydroxylase) in the substantia nigra were studied at both light and electron microscopic levels using a pre-embedding double-labeling immunocytochemical method. Many substance P-containing terminals were found to form synapses directly with dendrites and somata of nigral dopaminergic neurons. Since most of the substance P-containing axon terminals arise from the striatum, this result suggests that striatal substance P neurons can have monosynaptic influence on nigral dopaminergic neurons.
Chang
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Department of Anatomy and Neurobiology, University of Tennessee, Memphis, College of Medicine 38163.
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000032:analysis* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*; D013378:Substantia Nigra / Q000032:analysis* / Q000648:ultrastructure; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D013373:Substance P; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine