Neutralization of anti-myelin basic protein by cerebrospinal fluid of multiple sclerosis patients in clinical remission.
Autoantibodies to myelin basic protein (anti-MBP) can be detected in the cerebrospinal fluid (CSF) of MS patients using a solid phase radioimmunoassay. Acute relapses of MS are characterized by an elevated, above unity, free (F) to bound (B) anti-MBP ratio; while in contrast, patients with chronic progressing disease have a low, below unity, free to bound ratio of anti-MBP. As patients with acute relapses enter into remission, the F/B anti-MBP ratio gradually decreases and eventually the level of these autoantibodies becomes undetectable. Neutralization of free anti-MBP was observed in intra- and interpatient experiments in which CSF from MS patients in remission was reacted with CSF of patients with acute relapses. Inhibition of anti-MBP neutralization was produced by CSF from MS patients with chronic progressing disease.
Warren
K G
KG
Department of Medicine (Neurology), University of Alberta, Edmonton, Canada.
Catz
I
I
D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology*
D001323:Autoantibodies; D004676:Myelin Basic Protein