title: Further investigation on the high-conductance ion channel of the inner membrane of mitochondria.
abstract: By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.
authors: Dipartimento di Chimica Biologica, Universitá di Padova, Italy.
authors: M C
authors: MC
authors: Sorgato
authors: O
authors: O
authors: Moran
authors: V
authors: V
authors: De Pinto
authors: B U
authors: BU
authors: Keller
authors: W
authors: W
authors: Stuehmer
mesh_terms: D000818:Animals; D003471:Cuprizone / Q000494:pharmacology; D004024:Dicyclohexylcarbodiimide / Q000494:pharmacology; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008081:Liposomes; D008564:Membrane Potentials; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D008081:Liposomes; D009840:Oligomycins; D004024:Dicyclohexylcarbodiimide; D003471:Cuprizone