Serine proteinase inhibitors as acute phase reactants in liver disease.
alpha 1-Antitrypsin, alpha 1-antichymotrypsin and angiotensinogen are three genetically homologous acute phase reactants which belong to the super family of serine proteinase inhibitors (serpins). In this report the dissociate expression of these respective genes in various liver diseases or after exposure to estrogen is emphasized. In addition, the influence of abnormal genetic variants on plasma levels of these proteins and on liver cell function is discussed.
Eriksson
S G
SG
Department of Medicine, Malmö General Hospital, Sweden.
Carlson
J A
JA
Lindmark
B E
BE
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000808:Angiotensinogen / Q000097:blood; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D015843:Serpins / Q000097:blood*; D000514:alpha 1-Antichymotrypsin / Q000097:blood / Q000172:deficiency; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency
D000209:Acute-Phase Proteins; D015843:Serpins; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000808:Angiotensinogen