[Effect of inhibitors that destroy cytoskeleton structures on the antiviral and antiproliferative activity of interferons].
The effect of a number of drugs (vincristine, vinblastine, cytochalasin B, colcemid, colchamine) destroying cytoskeleton structures (microtubules and microfilaments) in combination with homologous interferon was studied in L920 and CaOv cells. The above substances were shown to inhibit the antiviral and enhance (from additivity to synergism) the antiproliferative effect of interferons under study.
Solov'eva
M F
MF
Krispin
T I
TI
Shloma
D V
DV
Kalmakhelidze
K A
KA
Balandin
I G
IG
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003599:Cytoskeleton / Q000187:drug effects*; D004357:Drug Synergism; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D014407:Tumor Cells, Cultured
D007372:Interferons
Vliianie ingibitorov, razrushaiushchikh struktury tsitoskeleta, na antivirusnuiu i antiproliferativnuiu aktivnost' interferonov.