title: [Immediate results of the use of prospidin in a cyanoacrylate glue compound in cancer of the esophagus].
abstract: Antitumor efficacy of a medical adhesive MK-8-based polymer drug composition with prospidin has been studied in 49 Wistar rats, and the kinetics of the drug elimination has been followed up in 112 rats. The findings evidence a prolongation of a relapse-free period and a longer survival of the animals. Clinical trials of the composition have been carried out. Of the 70 patients with esophageal carcinomas 52 ones had local disseminated forms, conforming to T4P3-4 indices. Application of the adhesive composition has not increased the rate of postoperative complications and in some cases considerably prolonged the life span of patients after palliative surgery.
authors: V I
authors: VI
authors: Chissov
authors: A S
authors: AS
authors: Mamontov
authors: I G
authors: IG
authors: Rusakov
authors: K G
authors: KG
authors: Shchitkov
authors: A Ia
authors: AIa
authors: Akimova
authors: A I
authors: AI
authors: Il'ina
authors: A B
authors: AB
authors: Volokhov
authors: M M
authors: MM
authors: Akhmetov
mesh_terms: D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D002296:Carcinosarcoma / Q000601:surgery; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004341:Drug Evaluation; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010879:Piperazines / Q000008:administration & dosage*; D011183:Postoperative Complications; D011447:Prospidium / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000601:surgery; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D003487:Cyanoacrylates; D046911:Macromolecular Substances; D010879:Piperazines; D014014:Tissue Adhesives; C007166:cyacrin; D011447:Prospidium
vernacular_title: Neposredstvennye rezul'taty primeneniia prospidina, deponirovannogo tsianakrilatnoĭ kleevoĭ kompozitsieĭ, pri rake pishchevoda.