Effect of recombinant interleukin-1 on mRNA levels in rat liver.
Levels of rat liver mRNA for the plasma proteins albumin, apolipoprotein E, transthyretin, transferrin, alpha 1-acid glycoprotein, major acute-phase alpha 1-protein, and the beta-chain of fibrinogen were measured after intraperitoneal injection of interleukin-1 alpha (IL-1). A maximum response of mRNA levels for most of the plasma proteins studied was reached between 6 and 10 h after injection of IL-1. The results suggest that at the dosage used, IL-1 alone does not elicit a typical acute-phase response of the plasma protein-synthesizing system of the liver.
De Jong
F A
FA
Biotechnology Australia Pty. Ltd., Roseville, N.S.W., Australia.
Birch
H E
HE
Schreiber
G
G
D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011915:Rats, Inbred BUF; D011994:Recombinant Proteins / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D001057:Apolipoproteins E; D007375:Interleukin-1; D012333:RNA, Messenger; D011994:Recombinant Proteins