Basophil histamine release studies in the evaluation of a new anaesthetic agent.
Propofol (2,6-diisopropylphenol) has recently been introduced into clinical practice as an induction agent. This study evaluated the effect of propofol on basophil histamine release in 13 healthy subjects. No release was demonstrated in 11 subjects. Two subjects released histamine at the highest drug concentration, one also releasing at lower concentrations. Both subjects whose basophils released histamine in response to propofol were anaesthetists using the drug during the course of their practice.
Withington
D E
DE
Chemistry Department, University College London, UK.
D000777:Anesthetics / Q000494:pharmacology; D001491:Basophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol
D000777:Anesthetics; D010636:Phenols; D015742:Propofol