Effects of glutathione, as the dextran conjugate, on acetaminophen-induced hepatotoxicity.
Glutathione was covalently attached to dextran (T-40) by the CNBr activation method. In mice given a lethal dose of acetaminophen, the 30-d survival rate increased progressively with coadministration of the conjugate, whereas little improvement was found when free glutathione was given. The dextran conjugate of glutathione maintained the serum transaminase activities at lower levels after acetaminophen administration, giving effective protection against acetaminophen hepatotoxicity.
Kaneo
Y
Y
Fujihara
Y
Y
Tanaka
T
T
Kozawa
Y
Y
Mori
H
H
Iguchi
S
S
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003911:Dextrans; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D003911:Dextrans; D000082:Acetaminophen; D005978:Glutathione