title: Site-directed neovessel formation in vivo.
abstract: Angiogenesis is an important component of organogenesis and wound repair and occurs during the pathology of oncogenesis, atherogenesis, and other disease processes. Thus, it is important to understand the physiological mechanisms that control neovascularization, especially with methods that permit the molecular dissection of the phenomenon in vivo. Heparin-binding growth factor-1 was shown to bind to collagen type I and type IV. When complexed with gelatin, heparin-binding growth factor-1 can induce neovascularization at polypeptide concentrations that are consistent with the biological activity of the mitogen in vitro. The adsorption strategy induces rapid blood vessel formation at and between organ- and tissue-specific sites and permits recovery of the site-specific implant for examination and manipulation by molecular methods.
authors: Laboratory of Molecular Hematology, National Heart, Lung and Blood Institute, Bethesda, MD 20892.
authors: J A
authors: JA
authors: Thompson
authors: K D
authors: KD
authors: Anderson
authors: J M
authors: JM
authors: DiPietro
authors: J A
authors: JA
authors: Zwiebel
authors: M
authors: M
authors: Zametta
authors: W F
authors: WF
authors: Anderson
authors: T
authors: T
authors: Maciag
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000166:cytology; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix; D016220:Fibroblast Growth Factor 1; D005780:Gelatin / Q000378:metabolism; D006133:Growth Substances / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D009389:Neovascularization, Pathologic; D051381:Rats; D013630:Tampons, Surgical
chemical_list: D006133:Growth Substances; D016220:Fibroblast Growth Factor 1; D005780:Gelatin; D006493:Heparin; D003094:Collagen