Thrombolytic agents of the preparation from the medicinal leeches.
The thrombolytic effect of an extract from medicinal leeches orally administered to rats was shown. This effect depends on the number of administrations and on the concentration of extract. It is due to the leech prostaglandins and enzyme destabilase. After the extraction of prostaglandins by ethylacetate the thrombolytic effect diminished by 45%. It is supposed that the leech-prostaglandins, like prostacyclin and its stable analogous, induce the release of tissue plasminogen activator from vessel walls. The thrombolytic effect of destabilase was demonstrated in experiments in vitro. We observed the phenomenon of increasing of glutaminase activity of citrate blood and the appearance of amidolytic and destabilase activity.
Baskova
I P
IP
Laboratory of Blood Coagulation, Moscow State University, USSR.
Nikonov
G I
GI
Khalil
S
S
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000032:analysis / Q000494:pharmacology*; D005972:Glutaminase / Q000378:metabolism; D007865:Leeches / Q000032:analysis*; D008055:Lipids / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology; D051381:Rats; D012469:Salivary Glands / Q000032:analysis*; D013927:Thrombosis / Q000097:blood / Q000201:enzymology
D005343:Fibrinolytic Agents; D008055:Lipids; D011453:Prostaglandins; D005337:Fibrin; D010450:Endopeptidases; C045348:fibrin destabilase; D005972:Glutaminase