title: Pregnancy-associated protein-A does not improve predictability of pregnancy success or failure over human chorionic gonadotropin levels in early normal and abnormal pregnancy.
abstract: In the present study we sought to compare levels of PAPP-A and hCG produced by different types of pregnancy: normal, ectopic, threatened abortion and molar pregnancy after evacuation. The gestations ranged from 13 to 122 days. Serum levels of both PAPP-A and hCG were measured and compared. Chi squares analysis were predictive only for increasing trends in hCG as well as decreasing trends of both hCG and PAPP-A. Analysis of variance and linear discriminant function used to evaluate results suggested that PAPP-A did not improve predictability of hCG. The values of PAPP-A levels for the postevacuation molar pregnancies barely exceeded the lower limit of detection; thus, no meaningful comparisons could be made.
authors: Eastern Virginia Medical School, Medical College of Hampton Roads, Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Norfolk 23510.
authors: C C
authors: CC
authors: Coddington
authors: M J
authors: MJ
authors: Sinosich
authors: E G
authors: EG
authors: Boston
authors: J J
authors: JJ
authors: Bartko
authors: G D
authors: GD
authors: Hodgen
mesh_terms: D000033:Abortion, Threatened / Q000097:blood; D000704:Analysis of Variance; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005544:Forecasting; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011252:Pregnancy Complications, Neoplastic / Q000097:blood; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000378:metabolism*; D011271:Pregnancy, Ectopic / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011863:Radioimmunoassay; D012016:Reference Values; D014328:Trophoblastic Neoplasms / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A