Subacute cutaneous lupus erythematosus lesions precipitated by griseofulvin.
Skin eruptions with features of subacute cutaneous lupus erythematosus occurred in a patient with dermatomyositis who was taking griseofulvin. The patient had antibodies against SSA/Ro and SSB/La antigens. Skin rashes disappeared after discontinuation of griseofulvin and recurred on challenge with the drug. These findings support previous studies that the photoactive drug may be synergistic with anti-SSA/Ro antibody to produce lesions of subacute cutaneous lupus erythematosus.
Miyagawa
S
S
Department of Dermatology, Nara Medical University, Japan.
Okuchi
T
T
Shiomi
Y
Y
Sakamoto
K
K
D000328:Adult; D001706:Biopsy; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006118:Griseofulvin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007633:Keratins; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000276:immunology; D012867:Skin / Q000473:pathology
D006118:Griseofulvin; D007633:Keratins