[Vestibulo-protective properties of regulatory peptides].
Endogenous opioid peptides take an active part in the pathogenesis of motion sickness (MS). Some regulatory peptides (substances P, gamma and des-tyr-gamma-endorphins) manifest antiemetic properties, unlike opioid peptides and morphine. Thus, we have examined the vestibulo-protective properties of some regulatory peptides during simulation of MS in cats. Vestibulo-protective properties have been discovered in some peptides: sweet water hydra undecapeptide, substances P, gamma and des-tyr-gamma-endorphins. It has been suggested that regulatory peptides take an active part in the genesis of vestibulo-protective disorders during motion sickness.
Drozd
Iu V
IuV
Iasnetsov
V V
VV
Shashkov
V S
VS
D000818:Animals; D002415:Cats; D004723:Endorphins / Q000627:therapeutic use; D008297:Male; D009041:Motion Sickness / Q000517:prevention & control*; D010446:Peptide Fragments / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use*; D013373:Substance P / Q000627:therapeutic use; D014722:Vestibule, Labyrinth / Q000187:drug effects*; D018823:gamma-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D010455:Peptides; D013373:Substance P; D018823:gamma-Endorphin; C018903:gamma-endorphin, des-Tyr(1)-
O vestibuloprotektornykh svoĭstvakh nekotorykh reguliatornykh peptidov.