Long-term effects of substance P on the isolated guinea pig trachea.
The undecapeptide substance P(SP) and its C-terminal sequence SP-5-11 induced a dose-dependent contraction of the isolated guinea pig trachea. SP-5-11 had a more potent bronchoconstrictive action than SP-1-11. The distal part of the isolated guinea pig trachea showed a greater reagibility to SP-5-11 than the proximal one. There was a continuous increase of the amplitude of the SP-1-11-induced contractions when the neuropeptide was added several times at one-hour intervals. Incubation with 10(-6) M SP-1-11 for 5 h reduced the reagibility of the isolated guinea pig trachea to acetylcholine.
Schreiber
J
J
Research Institute of Lung Diseases and Tuberculosis, GDR.
Slapke
J
J
Nieber
K
K
Oehme
P
P
D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009928:Organ Specificity; D013373:Substance P / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D013373:Substance P