title: Endothelial communication. State of the art lecture.
abstract: By virtue of its location at the interface of flowing blood and vascular tissue, the endothelial cell monolayer is in a unique position for interactions with soluble and cellular elements of the blood on one side and with component cells of the vascular tissue on the other. This brief review outlines humoral and contact-mediated endothelial communication with other cells, particularly the resident cells of the vessel wall. Evidence for gap junctional communication channels between endothelium and vascular cells is summarized and discussed in relation to endothelial ion channel activity. Myoendothelial gap junctional communication is proposed as a mechanism involved in vasorelaxation, either independent of or in concert with secreted endothelium-derived relaxing factor(s).
authors: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
authors: P F
authors: PF
authors: Davies
authors: S P
authors: SP
authors: Olesen
authors: D E
authors: DE
authors: Clapham
authors: E M
authors: EM
authors: Morrel
authors: F J
authors: FJ
authors: Schoen
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001688:Biological Products / Q000502:physiology; D002450:Cell Communication; D003331:Coronary Vessels / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism; D008564:Membrane Potentials; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D009569:Nitric Oxide; D014666:Vasomotor System / Q000502:physiology
chemical_list: D001688:Biological Products; D007473:Ion Channels; D009569:Nitric Oxide; D000109:Acetylcholine