[The neurite growth stimulating effect of terrilytin on sensory neurons and the spinal cord in tissue culture].
Terrilytin (a protease) was found to promote neurite extension in chick embryo dorsal root ganglia and spinal cord in vitro. This protease was active at the concentration 10-50 ng/ml, which provided extensive neurite outgrowth in the bioassay, compared to the control. Terrilytin may be used for stimulating regenerating processes in nervous tissue.
Chalisova
N I
NI
Akoev
G N
GN
Bellendir
E N
EN
Salmagambetov
I U
IU
D000681:Amylases / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D046508:Culture Techniques; D004338:Drug Combinations / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D009416:Nerve Regeneration; D009475:Neurons, Afferent / Q000166:cytology / Q000187:drug effects*; D010447:Peptide Hydrolases / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
D004338:Drug Combinations; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Stimuliruiushchee rost neĭritov deĭstvie terrilitina na chuvstvitel'nye neĭrony i spinnoĭ mazg v kul'ture tkani.