[Cultivated cardiac muscle cells--a functional test system for the detection of autoantibodies against the beta-adrenergic receptor].
The cultured rat heart myocytes constitute a functional test system for the detection of autoantibodies directed against the beta 2-adrenergic receptor subtype. In the present experiments we used autoantibodies-containing gamma-globulin fractions isolated from the serum of allergic asthmatics. Our data show that the gamma-globulin fractions inhibited with high sensitivity and specificity the positive chronotropic effect of the beta 2-selective adrenergic agonist clenbuterol.
Wallukat
G
G
Zentralinstitut für Herz-Kreislauf-Forschung der Akademie der Wissenschaften der DDR, Berlin-Buch.
Wollenberger
A
A
D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002478:Cells, Cultured; D002976:Clenbuterol / Q000494:pharmacology; D009206:Myocardium / Q000276:immunology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D001323:Autoantibodies; D011943:Receptors, Adrenergic, beta; D005719:gamma-Globulins; D002976:Clenbuterol
Die kultivierte Herzmuskelzelle--ein funktionelles Testsystem zum Nachweis von Autoantikörpern gegen den beta-adrenergen Rezeptor.