Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin.
Streptomyces lividans TK21 possesses inducible ribosomal RNA methylase activity that confers high-level resistance to lincomycin and lower levels of resistance to certain macrolides. The methylase gene (designated lrm) is inducible by erythromycin and other macrolides and also by celesticetin (a lincosamide) but not by lincomycin. The lrm enzyme monomethylates the N6-amino group of adenosine at position 2058 within 23S-like ribosomal RNA.
Jenkins
G
G
Department of Biochemistry and Leicester Biocentre, University of Leicester, UK.
Zalacain
M
M
Cundliffe
E
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction / Q000187:drug effects; D008034:Lincomycin / Q000494:pharmacology*; D018942:Macrolides; D008745:Methylation; D012329:RNA, Bacterial / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism*; D013302:Streptomyces / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D012359:tRNA Methyltransferases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D018942:Macrolides; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D008034:Lincomycin; D012359:tRNA Methyltransferases