title: Lack of seasonal variation in pediatric lumbar cerebrospinal fluid neurotransmitter metabolite concentrations.
abstract: Seasonal variation of cerebrospinal fluid (CSF) monoamines, particularly 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) has been reported for psychiatrically ill and normal adults. Circannual variability was examined for a group of 72 children (mean age = 159.4 +/- 40.3 (SD), range 77-238 months), with a primary diagnosis of obsessive-compulsive disorder (OCD) or disruptive behavior disorder (DBD) (attention deficit disorder, oppositional disorder and/or conduct disorder), from whom CSF had been obtained systematically. There were no seasonal differences in mean concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), HVA, or 5-HIAA, either for the group as a whole, for the separate diagnostic (OCD vs DBD) categories or for the pre-pubertal subgroup. Log-corrected HVA concentrations for the Tanner IV and V subgroup differed by season with summer concentrations less than those of fall (P = 0.06) and winter (P = 0.005). The results suggest that pubertal changes may play a role in any expression of circannual variability.
authors: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.
authors: S E
authors: SE
authors: Swedo
authors: M J
authors: MJ
authors: Kruesi
authors: H L
authors: HL
authors: Leonard
authors: S D
authors: SD
authors: Hamburger
authors: D L
authors: DL
authors: Cheslow
authors: M
authors: M
authors: Stipetic
authors: W Z
authors: WZ
authors: Potter
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002648:Child; D002653:Child Behavior Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D005260:Female; D006018:Glycols / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012621:Seasons
chemical_list: D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid