[Ionic selectivity of bilayer lipid membranes modified by triforine].
It is found that bilayer lipid membranes acquire little cationic selectivity in the presence of systemic fungicide triforine at physiological pH, and besides potassium selectivity exceeds the sodium one. A decrease of pH to 3.5 leads to substitution of cationic selectivity by the anionic one. It is suggested that selectivity of the membranes modified by triforine is determined both by charge and dipole moments of the fungicide molecule.
Golubev
V N
VN
Kontush
A S
AS
D005659:Fungicides, Industrial / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008051:Lipid Bilayers; D010539:Permeability; D010879:Piperazines / Q000494:pharmacology*
D005659:Fungicides, Industrial; D007473:Ion Channels; D008051:Lipid Bilayers; D010879:Piperazines; C012591:triforine
Ionnaia izbiratel'nost' bisloĭnykh lipidnykh membran, modifitsirovannykh triforinom.