[Mechanisms of thrombin-induced plasminogen activator release].
The protein kinase C inhibitor H7 (10(-5) mol/l) is able to inhibit the thrombin-induced t-PA release in the isolated perfused pig ear. The thrombin-induced t-PA release can be blocked by increasing the intracellular c-AMP via either the activation of adenylate cyclase by means of forskolin, or the inhibition of the phosphodiesterase by means of motapizone or milrinone. Protein kinase C is assumed to be involved in the process of thrombin-induced t-PA release.
Klöcking
H P
HP
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
Hoffmann
A
A
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D007546:Isoquinolines / Q000494:pharmacology; D020105:Milrinone; D010716:Phosphatidylinositols / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011724:Pyridazines / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013552:Swine; D013917:Thrombin / Q000494:pharmacology*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D007546:Isoquinolines; D010716:Phosphatidylinositols; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011724:Pyridazines; D011728:Pyridones; D000584:Amiloride; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; C051270:motapizone; D000242:Cyclic AMP; D011493:Protein Kinase C; D013917:Thrombin; D010959:Tissue Plasminogen Activator; D020105:Milrinone
Zum Mechanismus der Thrombin-induzierten Plasminogenaktivatorfreisetzung.