Some neuropeptides as modulators of experimental contact allergy.
The rôle of some peptides in allergic contact dermatitis was investigated. The neuropeptides: substance P (SP), vasoactive intestinal peptide (VIP) and somatostatin, as well as the SP antagonist spantide, were injected into the same skin sites as the antigen in patients with contact allergy to nickel. The neuropeptides did not influence the eczematous reaction but spantide diminished it. This might speak for a pathogenetic rôle of SP in allergic contact dermatitis.
Wallengren
J
J
Department of Dermatology, Lund University, Malmö, Sweden.
Möller
H
H
D000700:Analgesics / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D009479:Neuropeptides / Q000494:pharmacology*; D010328:Patch Tests; D013004:Somatostatin / Q000494:pharmacology; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D000700:Analgesics; D009479:Neuropeptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; C042867:spantide