title: Basophil degranulation test in house dust mite allergy: diagnostic value.
abstract: After reviewing the experience of various authors we applied the Basophil Degranulation Test (BDT) in the study of sensitization to Dermatophagoides pteronyssinus, so as to evaluate its diagnostic use. Fifty-five patients with asthma and/or rhinitis and a positive skin test to the mentioned antigen, as well as 20 control subjects were studied. The results demonstrated a sensitivity of 65.5% and a specificity of 80% with an efficiency index of 69.5%. We did not find any significant correlation with the histamine release test (r = 0.236). The data obtained and the proper limitations of the technique led us to consider the BDT to have a limited application in routine allergy diagnosis.
authors: Departamento de Alergologia, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
authors: X
authors: X
authors: Feliu
authors: C G
authors: CG
authors: de la Cuesta
authors: J G
authors: JG
authors: Castillo
authors: M L
authors: ML
authors: Sanz
authors: A
authors: A
authors: Oehling
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000209:etiology*; D015549:Basophil Degranulation Test; D002648:Child; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D007159:Immunologic Tests; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D011237:Predictive Value of Tests; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides