Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells.
Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine.
Hachisuka
H
H
Department of Dermatology, Kurume University School of Medicine, Japan.
Nomura
H
H
Sakamoto
F
F
Mori
O
O
Okubo
K
K
Sasai
Y
Y
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010529:Peritoneal Cavity; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000037:antagonists & inhibitors*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D062367:ortho-Aminobenzoates; D013373:Substance P; D003189:p-Methoxy-N-methylphenethylamine; C012293:tranilast; D004205:Cromolyn Sodium; D007665:Ketotifen