T cell vaccination in monoclonal antibody-induced hyperacute experimental allergic encephalomyelitis.
Demyelinating inflammatory disease of the central nervous system-(CNS) can be a multifactorial process mediated by cellular and antibody-mediated immune processes. In rats, hyperacute disease progression and severe demyelination can be induced in experimental allergic encephalomyelitis (EAE)-diseased animals by injection of a monoclonal antibody, 8-18C5, specific for an oligodendrocyte cell surface glycoprotein. Here we demonstrate that this antibody-induced hyperacute EAE can be prevented by 'vaccination' with myelin basic protein (MBP)-specific T cells. Thus, the 8-18C5 antibody-mediated disease process is critically dependent on inflammatory processes induced by T lymphocytes and T cell vaccination is highly effective in preventing the development of demyelinating CNS lesions.
Schluesener
H J
HJ
Clinical Research Unit for Multiple Sclerosis, Max-Planck-Society, Würzburg, F.R.G.
Meyermann
R
R
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000473:pathology; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D004676:Myelin Basic Protein / Q000008:administration & dosage; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination
D000911:Antibodies, Monoclonal; D004676:Myelin Basic Protein