[Blockage of a mitochondrial cationic channel by a mitochondrial addressing peptide].
A 13-residue peptide, including the sequence of the amino terminal end of cytochrome c oxidase subunit IV precursor, blocks a cationic channel from mitochondrial membranes. The effect is reversible and voltage-dependent. The blocking properties suggest that the peptide plugs the pore. Furthermore, when the transmembrane potential favours transfer, the peptide appears to be able to cross the channel.
Henry
J P
JP
Unité de Neurobiologie Physico-Chimique, C.N.R.S., Institut de Biologie Physico-Chimique, Paris.
Chich
J F
JF
Goldschmidt
D
D
Thieffry
M
M
D000595:Amino Acid Sequence; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D014357:Trypsin / Q000494:pharmacology
D007473:Ion Channels; D010455:Peptides; C061942:mitochondrial addressing peptide; D014357:Trypsin
Blocage d'un canal cationique de mitochondrie par un peptide d'adressage mitochondrial.