Effects of cocaine on the brain-stem auditory evoked potential in the Long-Evans rat.
The present study examined the effects of an acute psychoactive dose of cocaine hydrochloride (HCl) in the rat, using the brain-stem auditory evoked potential (BAEP) as an objective, quantitative measure of this substance's effects on brain and auditory electrophysiology. The animals were 8 adult Long-Evans rats (4 female, 4 male). BAEPs were recorded from skull screw electrodes during a baseline period as well as 30-90 min after cocaine HCl treatment (10 mg/kg, i.p.). Normothermia was maintained to control for possible temperature-related effects. Cocaine's effects on the BAEP were examined over a broad range of stimulus intensities (intensity profiles) and repetition rates (rate profiles). Cocaine prolonged latencies of several BAEP components at low stimulus intensities and shortened these latencies at high stimulus intensities. The average BAEP threshold was also increased by cocaine treatment. These results were not strong, but were suggestive of a recruitment type change in auditory function. Cocaine treatment had no convincing effects on the BAEP as a function of stimulus repetition rate.
Gritzke
R
R
Research Institute on Alcoholism, New York State Division of Alcoholism and Alcohol Abuse, Buffalo 14203.
Church
M W
MW
D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003042:Cocaine