A comparison of the IgG isotype expression in the so-called thymus-independent immune responses to alpha(1----3) and alpha(1----6) dextran.
This paper presents data on the IgG antibody response against two "thymus-independent" dextran (Dex) antigens from Leuconostoc mesenteroides, alpha(1----3) Dex B 1355S and alpha(1----6) Dex B 512F in BALB/c and C57BL/6 mice, which are considered to be responders or low responders to the respective antigen. The data point toward three common rules governing the two anti-Dex responses despite immunogenetic and antigenic disparities: (1) age dependency of the IgG isotype regulation of the response; (2) down-regulation of IgG isotype expression by T cells; and (3) individually determined preposition for IgG isotype formation in a given animal.
Boss
K
K
Department of Immunology, University of Münster, Federal Republic of Germany.
Stäb
F
F
Kölsch
E
E
D000375:Aging / Q000276:immunology; D000818:Animals; D003911:Dextrans / Q000276:immunology*; D006386:Hemagglutination Tests; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D011863:Radioimmunoassay
D003911:Dextrans; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; C040834:alpha-1,3-dextran; C041999:alpha-1,6-dextran