Immunoelectron microscopic demonstration of glycoprotein subunits in the FSH producing pituitary adenomas.
Immunoelectron microscopic observations disclosed the presence of FSH alpha, beta subunits in secretory granules and rough endoplasmic reticulum (RER). Golgi saccules were consistently negative. The presence of these subunits in secretory granules which were located in the vicinity of RER or perinuclear spaces (PNS) suggested the possible formation of secretory granules in RER or PNS. The tumor cells showed heterogeneity in size and immunoreactivity of the secretory granules but non-neoplastic cells showed uniformity in these aspects.
Osamura
R Y
RY
Department of Pathology, Tokai University School of Medicine, Bohseidai, Kanagawa-ken, Japan.
D000236:Adenoma / Q000648:ultrastructure*; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000032:analysis*; D037201:Follicle Stimulating Hormone, beta Subunit; D015292:Glycoprotein Hormones, alpha Subunit / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000648:ultrastructure*
D037201:Follicle Stimulating Hormone, beta Subunit; D015292:Glycoprotein Hormones, alpha Subunit; D005640:Follicle Stimulating Hormone