Topical interferon for treating condyloma acuminata in women.
We conducted a randomized, double-blind, placebo-controlled trial of two forms of topical interferon therapy for condyloma acuminata in women. Gel containing 10(6) IU of leukocyte interferon/g, with or without nonoxynol-9, was compared with treatment with gel base alone. Eighty-nine patients applied the gel three times a day for four weeks and were studied for at least 16 w. Side effects were generally mild and limited to the site of application for all three drugs. Although a transient, statistically significant therapeutic effect was noted early in the course of treatment with both interferon gels as compared with placebo, this effect was lost by the end of the follow-up period, possibly because of a generally high response rate in patients receiving placebo. Hence, there was no overall difference in the number of patients with a partial or complete response to any of the agents by the end of therapy or by the end of the study.
Keay
S
S
Department of Medicine, Stanford University School of Medicine, California 94305.
Teng
N
N
Eisenberg
M
M
Story
B
B
Sellers
P W
PW
Merigan
T C
TC
D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D003218:Condylomata Acuminata / Q000628:therapy*; D003902:Detergents / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use; D011897:Random Allocation
D003902:Detergents; D004338:Drug Combinations; D005782:Gels; D017137:Nonoxynol; D011092:Polyethylene Glycols; D007372:Interferons