title: Histogenesis of renal cell carcinoma and renal oncocytoma. An immunohistochemical study.
abstract: The histogenesis of renal cell carcinoma and oncocytoma is controversial. We compared immunohistochemical profiles of normal kidney, nine carcinomas, and six oncocytomas. Carcinomas and oncocytomas expressed the following antigens respectively: proximal tubule--Uro 3 (56 & 67%), alpha-1-antitrypsin (89 & 50%); proximal and distal tubule--Uro 10 (67 & 83%); distal tubule--B2-microglobulin (100 & 100%); distal/medullary tubule--epithelial membrane antigen (89 & 83%), neuron-specific enolase (78 & 100%), glandular cytokeratin (78 & 100%), epidermal keratin (67 & 67%); and medullary tubule--Uro 8 (89 & 83%). All tumors, except one oncocytoma, had at least one positive reaction for each antigen group. Oncocytomas predominantly stained for distal/medullary tubular antigens; none showed a predominance of proximal tubular antigens. Carcinomas also demonstrated largely distal/medullary tubule antigens; 44% showed prominence of proximal tubular antigens as well. Assignment of an exclusive proximal, distal or medullary tubule origin to renal neoplasms does not appear valid. Divergent histogenesis from a precursor stem cell is likely.
authors: Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia.
authors: C
authors: C
authors: Cohen
authors: P A
authors: PA
authors: McCue
authors: P B
authors: PB
authors: Derose
mesh_terms: D000236:Adenoma / Q000276:immunology / Q000473:pathology*; D000941:Antigens / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000276:immunology / Q000473:pathology*; D007684:Kidney Tubules / Q000276:immunology; D014411:Neoplastic Stem Cells / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D000941:Antigens; D014746:Vimentin; D007633:Keratins