title: Mechanisms and regulation of ion transport in the renal collecting duct.
abstract: 1. In the present paper the ion transport function of the renal mammalian collecting duct and its regulation is briefly reviewed. 2. The epithelium is characterized by different cell types: principal cells, intercalated cells, type A, and intercalated cells, type B. 3. Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells. 4. Intercalated cells of type A, which prevail in the outer medullary collecting duct, secrete H+ and intercalated cells of type B, which are most frequent in the late cortical collecting duct, secrete HCO3-. 5. This specialization of different cells in transporting individual ions provides the basis for the efficient adaptive regulation of urinary ion excretion.
authors: Zentrum der Physiologie, J. W. Goethe-Universität, Frankfurt, FRG.
authors: E
authors: E
authors: Frömter
mesh_terms: D000818:Animals; D001692:Biological Transport; D007473:Ion Channels / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*; D007685:Kidney Tubules, Collecting / Q000502:physiology*; D008322:Mammals
chemical_list: D007473:Ion Channels