Injections of papaverine and regitine into the corpora cavernosa for erectile dysfunction: clinical results in 60 patients.
After evaluating approximately 500 patients to identify the cause of erectile dysfunction, I selected 60 patients to receive a therapeutic injection of the vasoactive drugs papaverine and phentolamine mesylate (Regitine) into the corpora cavernosa. Fifty-two patients (87%) obtained erections that were adequate for sexual intercourse; these patients continued a self-injection program. Older patients with vasculogenic erectile dysfunction responded poorly. Ten patients, seven of whom had responded adequately, subsequently had implantation of a penile prosthesis. Although the self-injection group had few complications, 16 of 30 patients (53%) who had long-term follow-up subsequently discontinued the injections.
Nelson
R P
RP
Department of Urology, Medical University of South Carolina, Charleston 29425-2280.
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage* / Q000627:therapeutic use; D010646:Phentolamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D010208:Papaverine; D010646:Phentolamine