Capreomycin kinetics in renal impairment and clearance by hemodialysis.
The single-dose kinetics of capreomycin are described for 12 renal patients and seven healthy control subjects. Creatinine clearances (CrCl) ranged from zero to 121 ml/min. After single-dose intravenous infusions, mean +/- SD capreomycin clearance values (L/kg/h x 10(-2)) were 0.558 +/- 0.160 for the dialysis group (n = 4, CrCl = 1.4 +/- 1.9), 1.77 +/- 0.45 for the moderate renal group (n = 3, CrCl = 25 +/- 5), 2.82 +/- 1.52 for the mild renal group (n = 4, CrCl = 46 +/- 5), and 5.73 +/- 1.54 for the normal renal group (n = 7, CrCl = 109 +/- 11); p less than 0.01, using analysis of variance. The correlation between capreomycin clearance and CrCl was r = 0.90. Hemodialysis cleared clinically significant amounts of capreomycin. These data imply that capreomycin maintenance doses need to be reduced for renal patients.
Lehmann
C R
CR
Clinical Pharmacy Service, USAF Medical Center, San Antonio, Texas.
Garrett
L E
LE
Winn
R E
RE
Springberg
P D
PD
Vicks
S
S
Porter
D K
DK
Pierson
W P
WP
Wolny
J D
JD
Brier
G L
GL
Black
H R
HR
D000293:Adolescent; D000328:Adult; D000368:Aged; D002207:Capreomycin / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D008875:Middle Aged; D012016:Reference Values; D006435:Renal Dialysis
D002207:Capreomycin