title: Frequency of pancreatitis in fulminant hepatic failure using isoenzyme markers.
abstract: Evidence of acute pancreatitis was sought in 35 patients with fulminant hepatic failure. Total amylase was raised in 22 patients and isoenzyme separation showed a distinct P3 isoenzyme (indicative of pancreatitis) in 14. In four patients with marked hyperamylasaemia (greater than 1000 U/l) the predominant isoenzyme was the salivary fraction. Pancreatic lipase was abnormally raised (greater than 200 U/l) in 34 patients but exceeded 1000 U/l in 12 of the 14 with a distinct P3 isoenzyme. Thus on the basis of a distinct P3 isoenzyme of amylase and an increased pancreatic lipase activity evidence of pancreatitis was found in 34% of patients in this series.
authors: Liver Unit, Kings College Hospital, Denmark Hill, London.
authors: R J
authors: RJ
authors: Ede
authors: K P
authors: KP
authors: Moore
authors: W J
authors: WJ
authors: Marshall
authors: R
authors: R
authors: Williams
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000097:blood*; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008049:Lipase / Q000097:blood*; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D007527:Isoenzymes; D008049:Lipase; D000681:Amylases