title: 2',5'-Oligoadenylate synthetase activity in the liver and peripheral blood mononuclear cells of chronic hepatitis patients.
abstract: The in vivo activity of the interferon (IFN) system was studied in 39 patients with chronic hepatitis B (CHB) and in 24 patients with chronic hepatitis type non-A, non-B (CHNANB). 2',5'-Oligoadenylate synthetase (2-5 A synthetase) activity was monitored in the liver and peripheral blood mononuclear cells (PBMCs). Liver 2-5 A synthetase activity was higher in HBeAg-positive CHB and CHNANB patients than in HBeAg-negative CHB patients or controls. The IFN system appeared to be preserved in CH patients. In HBeAg-positive CHB patients the changes in DNA-P activity indicated that PBMC 2-5 A synthetase activity depended on replication of hepatitis B virus(HBV). Exogenous IFN administration in patients with HBeAg-positive CHB significantly elevated 2-5 A synthetase activity in PBMCs, as well as in the liver. In measurement of 2-5 A synthetase activity of CHB patients, the IFN system seems to be important in regulating HBV replication and in the exacerbation of liver inflammatory activity.
authors: Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors: Y
authors: Y
authors: Ogawa
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D006509:Hepatitis B / Q000201:enzymology*; D006515:Hepatitis B virus / Q000502:physiology; D006526:Hepatitis C / Q000201:enzymology*; D006521:Hepatitis, Chronic / Q000201:enzymology*; D006525:Hepatitis, Viral, Human / Q000201:enzymology*; D006801:Humans; D007372:Interferons / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D014779:Virus Replication
chemical_list: D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase