Antigen-specific lymphocyte clone elimination and reappearance in guinea pigs using 125I-labelled horse serum albumin.
T cells in the blood and spleen of guinea pigs fixed significantly higher quantities of radiolabelled antigen on day 4 following injection than did B cells or macrophages. Fixed radioactivity produced continuous radiation damage on the cells involved and the antigen-specific lymphocyte clone disappeared. This was shown by the absence of antibody production in the sera determined by passive haemagglutination. The reappearance of the specific lymphocyte clone required more than 20 days.
Pongrácz
J
J
Institute of Pathophysiology, University Medical School of Debrecen, Hungary.
Olveti
E
E
Csaba
B
B
D000818:Animals; D000910:Antibodies, Heterophile / Q000096:biosynthesis; D001402:B-Lymphocytes; D002470:Cell Survival; D002999:Clone Cells / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D000939:Epitopes / Q000008:administration & dosage*; D006168:Guinea Pigs; D006736:Horses; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008212:Lymphocyte Depletion; D008264:Macrophages; D012709:Serum Albumin / Q000493:pharmacokinetics*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D000910:Antibodies, Heterophile; D000939:Epitopes; D007457:Iodine Radioisotopes; D012709:Serum Albumin