[The Leu 7+ cell population of the human pancreas: preferential distribution and morphology].
Anti-Leu 7 is a monoclonal antibody which recognizes an antigenic determinant present on the surface of a subset of human large granular lymphocytes and on central and peripheral neural elements. Furthermore it cross-reacts with an intracellular protein of secretory granule matrix in neuroendocrine cells. The presence of Leu 7+ cells has been studied in lymphoid and non-hemopoietic organs. We have analyzed the Leu 7 positivity in six pancreata from cadaver donors by means of immunocytochemical methods. Leu 7+ cells were found to be also present in the exocrine portion of the organ in which they represent a nonhomogeneous cellular population. In fact, two different types of Leu 7+ elements populate the exocrine pancreas: a, Leu 7+ cells showing an intracellular granule positivity; b, Leu 7+ cells showing surface positivity. The endocrine pancreas, in contrast, contains the majority (85%) of Leu 7+ elements, belonging to the intracellular positive type only.
Leprini
A
A
Valente
U
U
Barocci
S
S
Fontana
I
I
Leprini
A E
AE
Nocera
A
A
D000911:Antibodies, Monoclonal / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis*; D002102:Cadaver; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology* / Q000276:immunology; D010179:Pancreas / Q000166:cytology* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000939:Epitopes
La popolazione cellulare Leu 7+ del pancreas umano: distribuzione preferenziale e morfologia.