The peptidergic innervation of the developing mesenteric vascular bed in the rat.
We have followed the development of perivascular nerve fibres using antisera to substance P, calcitonin gene related peptide, neuropeptide Y and vasoactive intestinal polypeptide in the mesenteric vascular bed of developing Sprague-Dawley rats. The pattern and density of innervation appeared to be determined by one week of age. The pattern of innervation by SP- and CGRP-positive fibres was similar. The pattern of innervation by neuropeptide Y-containing fibres was distinct from that of SP and CGRP. The VIP-positive fibre plexus was sparse and irregular compared with the others examined. The density of innervation by all fibre types was highest in the jejunal arteries.
Scott
T M
TM
Faculty of Medicine, Memorial University of Newfoundland, St John's, Canada.
Robinson
J
J
Foote
J
J
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D008638:Mesenteric Arteries / Q000254:growth & development / Q000294:innervation*; D008642:Mesenteric Veins / Q000254:growth & development / Q000294:innervation*; D009478:Neuropeptide Y / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide