[A radioisotope method for assessing the anaphylactogenicity of polymer drugs].
A radioisotope technique has been developed for the quantitative assessment of microcirculation disorder in a local anaphylactic focus of guinea pigs sensitized with horse immunoglobulin G and polyethyleneoxide conjugate with 2,4-dinitrophenol. The technique is based on the use of a radioactive tracer, dextran derivative, labelled with radionuclide 125I. The method can be used for studying a safety of new polymer-containing drugs.
Kulakov
V N
VN
Ivanov
A A
AA
Kalinin
N L
NL
Topchieva
I N
IN
Matveev
V A
VA
D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D003888:Desensitization, Immunologic / Q000379:methods; D003911:Dextrans / Q000276:immunology / Q000493:pharmacokinetics; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007114:Immunization / Q000379:methods; D007457:Iodine Radioisotopes; D008297:Male; D008970:Molecular Weight; D011108:Polymers / Q000633:toxicity*; D011865:Radioisotope Dilution Technique; D051381:Rats
D003911:Dextrans; D007457:Iodine Radioisotopes; D011108:Polymers
Radioizotopnyĭ metod otsenki anafilaktogennosti polimernykh lekarstvennykh sredstv.