[Selective inhibition by 3'-azido-2',3-dideoxythymidine-5'- triphosphate of reverse transcription in retrovirus A particles from the rat liver].
The data presented demonstrate that 3'-azido-2',3'-dideoxythymidine 5'-triphosphate [dTTP (3N3)] specifically inhibits reverse transcription of viral RNA in the endogenous retroviral A-type particles isolated from the rat liver. The inhibitory action of dTTP (3N3) is concerned the termination of DNA synthesis obviously due to the incorporation of this dideoxynucleotide into the 3'-end of the growing DNA chain.
Pyrinova
G B
GB
Kuz'minova
E A
EA
Salganik
R I
RI
Kraevskiĭ
A A
AA
Kukhanova
M K
MK
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004256:DNA Polymerase I / Q000378:metabolism; D054306:Dideoxynucleotides; D004926:Escherichia coli / Q000201:enzymology; D008099:Liver / Q000382:microbiology*; D012367:RNA, Viral / Q000235:genetics; D051381:Rats; D012190:Retroviridae / Q000187:drug effects / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors; D013698:Templates, Genetic; D013942:Thymine Nucleotides / Q000494:pharmacology*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000998:Antiviral Agents; D054306:Dideoxynucleotides; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D013942:Thymine Nucleotides; D015215:Zidovudine; C052873:zidovudine triphosphate; D004256:DNA Polymerase I
Selektivnoe tormozhenie 3'-azido-2',3-didezoksitimidin-5'- trifosfatom obratnoĭ transkriptsii v sostave retrovirusnykh chastits A-tipa iz pecheni krys.