title: Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.
abstract: Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: (Formula: see text).
authors: Pediatric Department Poliklinik, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
authors: W
authors: W
authors: Dorsch
authors: H
authors: H
authors: Wagner
authors: T
authors: T
authors: Bayer
authors: B
authors: B
authors: Fessler
authors: G
authors: G
authors: Hein
authors: J
authors: J
authors: Ring
authors: P
authors: P
authors: Scheftner
authors: W
authors: W
authors: Sieber
authors: T
authors: T
authors: Strasser
authors: E
authors: E
authors: Weiss
mesh_terms: D000485:Allergens / Q000494:pharmacology; D000490:Allium / Q000032:analysis*; D000818:Animals; D001249:Asthma / Q000517:prevention & control; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D004347:Drug Interactions; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D015289:Leukotrienes / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D013441:Sulfinic Acids / Q000494:pharmacology*; D013931:Thromboxanes / Q000096:biosynthesis*
chemical_list: D000485:Allergens; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D010972:Platelet Activating Factor; D013441:Sulfinic Acids; D013931:Thromboxanes; C100040:thiosulfinic acids