[Experimental studies of chemonucleolysis with aprotinin].
We have attend operatively exstirpated tissue of intervertebral disks to solution with 250.000 I. E. and 500.000 I.E. aprotinin. After preparation and colouring of the tissue we examinate by microscope. We couldn't find out neither a macroscopic nor microscopic evident effect of chemonucleolysis of aprotinin. Our opinion is, that an application of aprotinin to reduction of intradiscal pressure or to chemonucleolysis isn't effectively.
Klötzer
R
R
Martin
H
H
Meier
U
U
Gottschalk
J
J
Knopf
W
W
D007611:Aprotinin / Q000627:therapeutic use*; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects; D007404:Intervertebral Disc Chemolysis / Q000379:methods*; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*
D007611:Aprotinin
Experimentelle Untersuchungen zur Chemonukleolyse mit Aprotinin.