title: [Use of isometric load for evaluation of the anti-arrhythmia effect of drugs].
abstract: Possible use of pedal isometric stress for the assessment of antiarrhythmic effect of ethacizine was explored in 34 patients with various heart rhythm disorders. They showed similar results of pedal isometric stress test and 24-hour ECG monitoring. Heart rhythm monitoring in the presence of the acute test and a treatment course demonstrated complete agreement between positive results of the pedal isometric stress test and 24-hour ECG monitoring in 85% of the patients, exhibiting an obvious antiarrhythmic effect. The pedal isometric stress test may be useful for the assessment of antiarrhythmic medication efficacy.
authors: E B
authors: EB
authors: Gel'fgat
authors: R F
authors: RF
authors: Abdullaev
authors: V A
authors: VA
authors: Danilova
authors: A N
authors: AN
authors: Khalilov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000503:physiopathology; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009200:Myocardial Contraction / Q000187:drug effects*; D010640:Phenothiazines / Q000627:therapeutic use*; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy* / Q000503:physiopathology; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D010640:Phenothiazines; C046818:ethacizine
vernacular_title: Primenenie izometricheskoĭ nagruzki dlia otsenki anti-aritmicheskogo éffekta lekarstvennykh preparatov.