[Morphology and growth characteristics of human renal cell carcinoma in correlation to cytogenetic data].
Previous cytogenetical studies of renal cell carcinomas reported non-uniform results, but some chromosomes or chromosomal segments seemed to be affected more frequently by chromosomal aberration. This study was undertaken to determine a possible association between morphology, growth fraction (Ki-67, APAAP-method), and cytogenetical data of renal cell carcinomas. Our results show a variety of chromosomal aberrations, which do not correlate with morphological typing of the tumors. A single characteristic anomaly could not be found. There is an inverse correlation between complexity of chromosomal aberrations and size of growth fraction. For further interpretation of our results detailed molecular-genetic studies are necessary, which should investigate whether growth factors, oncogenes, or other genes are influenced by the reported chromosomal aberrations.
Krech
R H
RH
Fonatsch
C
C
Peters
B
B
Löhrs
U
U
D000954:Antigens, Surface / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology*; D002453:Cell Cycle; D006801:Humans; D007621:Karyotyping; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*
D000954:Antigens, Surface; D019394:Ki-67 Antigen
Morphologie und Wachstumsfraktion von Nierenzellkarzinomen des Menschen in Korrelation zu zytogenetischen Daten.