[Morphologic changes in the epithelium of the uterine cervix in long-term administration of the 19-norsteroid-containing oral hormonal contraceptives Non-Ovlon and gravistat].
The objective of this study was to give a contribution to the question whether there are changes in the uterine cervix after longterm application of 19-norsteroid-containing contraceptives Non-Ovlon and Gravistat relating to carcinogenesis. Histologic examinations have been performed on 19,760 cervical sections obtained from 280 women aged 25-45 years. 141 women had taken Non-Ovlon or Gravistat for at least 5 years, 139 women had never taken hormonal contraceptives. The cervices were equally obtained from surgical- and conization material from 1976 to 1982. The evaluation was made according to 108 single characteristics of quality, semiquantity and topography. These characteristics were evaluated by electronic data processing. Our investigations revealed no morphological evidence for a relation between longterm application of Non-Ovlon or Gravistat and the occurrence of squamous epithelial or adenomatous cervical neoplasias.
Geissler
U
U
Klinik für Gynäkologie und Geburtshilfe, Medizinischen Akademie Carl Gustav Carus Dresden.
D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects* / Q000473:pathology; D002715:Chlormadinone Acetate / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004338:Drug Combinations; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008875:Middle Aged; D009640:Norethindrone / Q000009:adverse effects*; D009644:Norgestrel / Q000009:adverse effects*; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000139:chemically induced* / Q000473:pathology
D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D002715:Chlormadinone Acetate; D009644:Norgestrel; D004997:Ethinyl Estradiol; C010260:Non-Ovlon; D019304:Ethinyl Estradiol-Norgestrel Combination; D009640:Norethindrone
Morphologische Veränderungen am Epithel der Cervix uteri bei Langzeiteinnahme der 19-norsteroidhaltigen oralen hormonalen Kontrazeptiva Non-Ovlon und Gravistat.