In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models.
Two new antineoplastic agents, a nitrosourea and a DNA-bis-intercalator have been studied in vivo by 31P magnetic resonance spectroscopy on a rat glioma and Walker carcinoma. On rat glioma, spectra are modified when the tumor is treated by the nitrosourea, showing the depletion of high-energy phosphates. On Walker carcinoma both drugs delay the tumor evolution to necrosis, showing important levels of high-energy phosphates on NMR spectra. There appears to be a great dependence upon energy metabolism during chemotherapy, depending on the nature and physiology of the observed tumor.
Le Moyec
L
L
Dept. of Neurosurgery, Kyoto Prefectural University of Medicine, Okasaki, Japan.
Naruse
S
S
Higuchi
T
T
Hirakawa
K
K
Watari
H
H
de Certaines
J D
JD
Roques
B P
BP
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010758:Phosphorus; D051381:Rats; D011919:Rats, Inbred Strains; D012521:Sarcosine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D002227:Carbazoles; D010758:Phosphorus; C039977:N-methylglycinamide; D005998:Glycine; C042804:ditercalinium; D012521:Sarcosine