Stimulation of sodium current by cyclic AMP is mediated through protein phosphorylation in Euhadra neurons.
The protein kinase inhibitors, protein kinase inhibitor isolated from rabbit muscle and isoquinolinesulfonamide, abolished the inward Na current which was elicited by cAMP.
Onozuka
M
M
Department of Anatomy, Gifu University School of Medicine, Japan.
Imai
S
S
Deura
S
S
Nishiyama
K
K
Ozono
S
S
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D004553:Electric Conductivity; D009474:Neurons / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits; D012908:Snails / Q000502:physiology*; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*
D010750:Phosphoproteins; D047428:Protein Kinase Inhibitors; D015222:Sodium Channels; D003994:Bucladesine; D000242:Cyclic AMP; D011494:Protein Kinases; D015056:1-Methyl-3-isobutylxanthine