title: Granular cells in odontogenic and non-odontogenic tumours.
abstract: Granular cells can occur in various odontogenic and non-odontogenic tumours. 5 granular cell lesions, one granular cell ameloblastoma, one so-called granular cell ameloblastic fibroma and three granular cell tumours were examined immunohistochemically for the intermediate filaments cytokeratin, vimentin, desmin, neurofilaments and the neural markers NSE and S-100 protein. The granular cell tumors (granular cell myoblastoma) showed positive staining for vimentin and S-100 protein. Only vimentin could be demonstrated in the granular cells of the so-called granular cell ameloblastic fibroma, whereas the granular cell ameloblastoma showed positive staining only for cytokeratin. A positive reaction with S-100 protein was not found in any of the odontogenic tumours. In our opinion the mesenchymal odontogenic granular cell is a fibroblast, whereas the epithelial granular cell is derived from enamel epithelium. The term "granular cell ameloblastic fibroma" is a misnomer, as a number of these tumours are probably central odontogenic fibromas exhibiting granular cell transformation.
authors: Institut für Pathologie der Ruhr Universität Bochum, Abteilung für allgemeine und orale Pathologie, Federal Republic of Germany.
authors: G H
authors: GH
authors: Rühl
authors: E
authors: E
authors: Akuamoa-Boateng
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D010751:Phosphopyruvate Hydratase