title: Improved survival following HLA-incompatible bone marrow transplantation. Munich Cooperative Group of Bone Marrow Transplantation.
abstract: In most centers allogeneic bone marrow transplantation is restricted to patients with HLA-identical siblings as donors. We have transplanted 16 patients with marrow of donors other than HLA-identical siblings. Seven patients were grafted in the years 1978 until 1984. Six died of transplant complications and one of recurrent leukemia. More recently 9 patients were transplanted following an improved immunosuppressive conditioning treatment derived from experimental studies in dogs. Four are alive and in continuous remission between more than 2 months and 2 years. 5 patients died, 3 from fungal infections, one from recurrent leukaemia and one early from endothelial leakage syndrome. Our results indicate that intensified immunosuppressive conditioning may improve the results of marrow transplantation from HLA-haploidentical donors.
authors: Medizinische Klinik III, Klinikum Grosshadern, Universität München.
authors: H J
authors: HJ
authors: Kolb
authors: C
authors: C
authors: Bender-Götze
authors: E
authors: E
authors: Holler
authors: J
authors: J
authors: Mittermüller
authors: H
authors: H
authors: Grosse-Wilde
authors: R
authors: R
authors: Wank
authors: R
authors: R
authors: Eckstein
authors: S
authors: S
authors: Scholz
authors: R J
authors: RJ
authors: Haas
authors: W
authors: W
authors: Mempel
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006680:HLA Antigens / Q000276:immunology*; D006239:Haplotypes; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D007938:Leukemia / Q000601:surgery*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery
chemical_list: D006680:HLA Antigens