[Prevention of arrhythmia in acute ischemia in conscious animals using a serotonin analog].
The state of the serotonergic system was studied in adaptation of rats to short-term non-damaging stress actions along with the possibility of protecting the heart of conscious animals against arrhythmias in acute ischemia with the serotonin analogue 4-nitro-5-methoxytryptamine. It was shown that the adaptation resulted in a significant increase in rat midbrain serotonin by 70%. Preliminary administration of the serotonin analogue 3 fold reduced the total duration of arrhythmias and approximately 5 fold--the heart fibrillation rate and the death rate of animals in acute ischemia. The data obtained are in agreement with the idea on the role of stress-limiting systems in prevention of stress-induced and ischemic damages of the organism. They show that protective effects of metabolites of these systems can be successfully reproduced with their synthetic analogues or activators.
Shabunina
E V
EV
Petrunin
I A
IA
Vinograd
L Kh
LKh
Manukhina
E B
EB
Meerson
F Z
FZ
D008735:5-Methoxytryptamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D005117:Cardiac Complexes, Premature / Q000517:prevention & control; D006352:Heart Ventricles; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009203:Myocardial Infarction / Q000150:complications* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives* / Q000032:analysis; D013312:Stress, Physiological / Q000378:metabolism; D013610:Tachycardia / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; C057766:4-nitro-5-methoxytryptamine; D012701:Serotonin; D008735:5-Methoxytryptamine
Preduprezhdenie aritmiĭ pri ostroĭ ishemii u bodrstvuiushchikh zhivotnykh s pomoshch'iu analoga serotonina.