Pharmacokinetics of intravenous enoximone in dialysis patients.
The new vasodilator and inotropic drug enoximone was given to dialysis patients as a single intravenous dose of 1 mg/kg. Plasma concentrations were measured up to 240 min. The mother compound enoximone reached a high plasma concentration intravenously, followed by a quick decline of the plasma concentration curve (t1/2 = 1.5 h), comparable to that of normal volunteers. The sulfoxide metabolite, however, had a tremendously prolonged half-life (t1/2 = 7.8 h) in comparison to healthy volunteers (t1/2 = 2.2 h). The volume of distribution of enoximone varies from 0.7-4.8 L/kg with a mean of 2.11 L/kg in comparison to 1.6 L/kg in healthy individuals. The area under the curve (AUC) of enoximone was 815.2 ng/ml/h, and that of the sulfoxide metabolite was 10,200.1 ng/ml/h.
Fiegel
P
P
Deutsche Klinik für Diagnostik, Wiesbaden, F.R.G.
Trenk
D
D
Jaehnchen
E
E
Dieterich
H A
HA
D000368:Aged; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017335:Enoximone; D005260:Female; D006207:Half-Life; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D002316:Cardiotonic Agents; D007093:Imidazoles; D017335:Enoximone