Changes in rat liver mRNA for alpha-1-acid-glycoprotein, apolipoprotein E, apolipoprotein B and beta-actin after mouse recombinant tumor necrosis factor injection.
Hybridization studies using specific cDNA probes have been used to determine the specific mRNA levels for apolipoproteins B and E, alpha 1 acid glycoprotein and beta actin in extracts of rat liver. Injection of rats with recombinant mouse tumor necrosis factor had led to a rapid increase in liver mRNA levels for alpha 1 acid glycoprotein (x 12) and for beta actin (x 2.5) whereas mRNA levels for Apolipoprotein B and E remained stable over the same period.
Delers
F
F
Laboratoire des proteines de la réaction inflamatoire, U.E.R. Biomédicale des Saints Pères, Paris, France.
Mangeney
M
M
Raffa
D
D
Vallet-Colom
I
I
Daveau
M
M
Tran-Quang
N
N
Davrinches
C
C
Chambaz
J
J
D000199:Actins / Q000096:biosynthesis / Q000378:metabolism; D000209:Acute-Phase Proteins / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D001055:Apolipoproteins B / Q000096:biosynthesis / Q000378:metabolism; D001057:Apolipoproteins E / Q000096:biosynthesis / Q000378:metabolism; D015152:Blotting, Northern; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009961:Orosomucoid / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
D000199:Actins; D000209:Acute-Phase Proteins; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D009961:Orosomucoid; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha