Diagnostic markers in human neurooncology. A progress report.
In this progress report, some of the most commonly used antibodies are discussed in regard to their immunohistochemical application to human neurooncology. The importance of determining the spectrum of antibody immunoreactivity in a wide panel of normal, reactive, and neoplastic tissues is stressed. in atypical and aberrant cases, immunopositivity needs to be interpreted with caution and in the context of all other available data. The demonstration of a well-characterized, cell type-specific marker in a tumor reflects not so much its cytogenesis as its differentiation potential and its capacity for metaplasia. The relation of an abnormal or aberrant expression of antigenic determinants to the process of neoplasia raises a number of intriguing questions to which research in the next few years will likely provide answers.
Rubinstein
L J
LJ
Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908.
D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology*; D018959:CD57 Antigens; D002453:Cell Cycle; D002454:Cell Differentiation; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D007120:Immunochemistry; D007381:Intermediate Filament Proteins / Q000276:immunology; D007382:Intermediate Filaments / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000032:analysis; D009423:Nervous System Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D016900:Neurofilament Proteins; D009479:Neuropeptides / Q000032:analysis; D018377:Neurotransmitter Agents / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D018959:CD57 Antigens; D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D010751:Phosphopyruvate Hydratase