[Studies using different human cell-culture systems for demonstrating interferon induction under in vitro conditions].
Five human cell culture systems (FL-cells, suspensions of tonsillar cells, FL-cells and suspensions of tonsillar cells combined, human fibroblasts, leukocyte suspensions) were tested with the international standard inducer Poly (IC) for the estimation of an in vitro induction of interferon under in vitro conditions. All induced cell systems have produced IFN. It can be concluded that alone the cell culture system represented by fibroblasts and leukocytes allow a reliable prediction concerning the induction of interferon under in vitro conditions.
Glück
B
B
Zentralinstitut für Mikrobiologie und experimentelle Therapie, AdW der DDR, Jena.
D000650:Amnion / Q000166:cytology; D002478:Cells, Cultured / Q000187:drug effects*; D004847:Epithelial Cells; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D014066:Palatine Tonsil / Q000166:cytology; D011070:Poly I-C / Q000494:pharmacology*
D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C
Untersuchungen mit verschiedenen humanen Zellkultursystemen zum Nachweis einer Interferon-Induktion unter In-vitro-Bedingungen.