Active immunization of human cancer with tumor cell-associated carbohydrate antigen.
The peanut agglutinin (PNA) receptors isolated from a tumor cell line could elicit antitumor activity by an active immunization. We report here the results of active immunization with a human PNA receptor glycoprotein on the tumor progression of cancer patients. A remarkable regression of cancer and a prolonged life span in patients were obtained after active immunization with a tumor cell-associated carbohydrate antigen.
Adachi
M
M
Japan Immunoresearch Laboratories Co. Ltd., Takasaki.
Inui
Y
Y
Suzuki
Y
Y
Ietomi
K
K
Orimo
K
K
Kobayashi
S
S
Joshita
T
T
Arai
T
T
Matsumoto
J
J
Okano
A
A
D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D002240:Carbohydrate Sequence; D000939:Epitopes; D006801:Humans; D007114:Immunization; D008562:Membrane Glycoproteins / Q000276:immunology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy*; D011975:Receptors, Mitogen / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000939:Epitopes; D008562:Membrane Glycoproteins; D011975:Receptors, Mitogen; C038223:peanut agglutinin receptor