Nucleolar organizer regions in transitional cell tumors of the bladder.
The traditional silver staining technique that identifies nucleolar organizer region-associated proteins has recently been adapted and applied to paraffin sections, and used to examine changes in nucleolar organizer region numbers in a variety of benign and malignant conditions. We describe herein the enumeration of nucleolar organizer regions in a variety of benign and malignant conditions of the transitional epithelium of the urinary bladder. While there is a statistical separation between normal and neoplastic groups, there is a degree of overlap between normal, inflammatory, dysplastic, and neoplastic urothelium.
Cairns
P
P
Department of Histopathology, East Birmingham Hospital, England.
Suarez
V
V
Newman
J
J
Crocker
J
J
D002278:Carcinoma in Situ / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002452:Cell Count; D006801:Humans; D009697:Nucleolus Organizer Region / Q000473:pathology*; D013194:Staining and Labeling; D001745:Urinary Bladder Diseases / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*