[The effect of single and repeated administration of penicillin on the structure of the endoplasmic network of the epithelial cells in the proximal tubules of rat nephrons].
In the endoplasmic reticulum (ER) of the rat proximal tubule nephron epithelial cells three morphologically different components can be distinguished: 1) tubes and cisternae distributed relatively diffusely in the cytoplasm; 2) cisternae of paramembranous ER located along the lateral boundaries of the cell (components 1 and 2 might be either smooth or granular); 3) constantly smooth ER consisting of narrow tubules accumulated in the shape of skeins or islets. The latter are closely adjacent to the basolateral plasmalemma. Single intraperitoneal injection of penicillin, as well as its nine times repeated injections in the same dosage (over the period of 3 days at equal intervals) resulted in ultrastructural changes of the cellular ER. Changes enhanced in the case of multiple injections involved the increase in the inner diameter of all ER components and a rise in the number of elements outlined by granular membranes. An intensive proliferation of component 3 was observed. The data obtained allow to suppose that the transport cell ER may directly participate in the process of intracellular transport of drugs, component 3 accumulating the substances transferred through the plasmalemma.
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D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010406:Penicillins / Q000008:administration & dosage*; D051381:Rats; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors
D010406:Penicillins
Vliianie odnorazovykh i povtornykh vvedeniui penitsillina na strukturu éndoplazmaticheskoĭ seti épitelial'nykh kletok proksimal'nykh kanal'tsev nefronov krys.