[Radio- and radio-chemosensitivity of human head and neck cancer cell line detected by human tumor clonogenic assay].
The radiosensitivity and radio-chemosensitivity of 3 series of human cancer cell lines were evaluated by human tumor clonogenic assay. The sources of cell lines were gingiva carcinoma (Ca9-22), uterus carcinoma (Hela) and gastric carcinoma (MKN-45). BLM and CDDP were used, and chemosensitivity of gingiva carcinoma tended to be higher than other cell lines. Radiosensitivity was same as MKN-45. Isobologram were employed for quantitation of the interaction between the irradiation and anti-cancer agents. In Ca9-22, the interaction of between gamma-rays, BLM and CDDP was supra-additive. Hela was also supra-additive, but in MKN-45, the interaction of between gamma-rays and BLM was sub-additive.
Suzuki
K
K
Fujii
M
M
Ishii
Y
Y
Mochizuki
F
F
Suzuki
K
K
Yamagata
M
M
Suzuki
H
H
Moriya
Y
Y
Abiko
Y
Y
Sakabe
T
T
D001761:Bleomycin / Q000627:therapeutic use; D005260:Female; D005887:Gingival Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014410:Tumor Stem Cell Assay; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
D009944:Organoplatinum Compounds; D001761:Bleomycin; C055423:didimethylsulfoxide dichloroplatinum(II)