Suspected chlorpyrifos toxicosis in a llama, and plasma pseudocholinesterase activity in llamas given chlorpyrifos.
Five days after treatment with chlorpyrifos, a 1.5-year-old male llama was unable to stand, had saliva flowing from its mouth, and had constricted pupils, hyperglycemia, a metabolic acidosis, and a plasma pseudocholinesterase activity of 111 IU/L. Mean (+/- 1 SD) plasma pseudocholinesterase activity of 29 healthy llamas was 233.76 +/- 51.55 IU/L. Five to 8 days after topical application of chlorpyrifos (25 mg/kg of body weight) to 3 healthy llamas, the pseudocholinesterase activity decreased to 38% to 62% of pretreatment (base-line) activity and returned to within 90% of base-line activity by the 36th to 48th day after treatment.
Pearson
E G
EG
College of Veterinary Medicine, Oregon State University, Corvallis 97331.
Craig
A M
AM
Lassen
E D
ED
D000818:Animals; D001188:Artiodactyla / Q000097:blood*; D002091:Butyrylcholinesterase / Q000097:blood*; D002161:Camelids, New World / Q000097:blood*; D004390:Chlorpyrifos / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D008297:Male
D002091:Butyrylcholinesterase; D002802:Cholinesterases; D004390:Chlorpyrifos