[Chemotherapy with Cisplatin-Phosphatidyl-choline-Lipiodol (CPL) suspension in unresectable hepatocellular carcinoma].
Twenty-seven patients with unresectable hepatocellular carcinoma (HCC) were treated with Cisplatin-Phosphatidyl-choline-Lipiodol (CPL) suspension. PR was obtained in two of ten cases (20%) by one shot therapy. AFP decreased in 9 of 10 patients by one shot therapy with a 62.1% rate of decrease. In all of 13 patients by TAE, AFP decreased and the rate of decrease was 64.8%. The concentration of CDDP in the peripheral venous blood was lower and continued longer than that of CDDP on the market. Nausea, vomiting and fever were noted in most cases as adverse effects, but they were slight. These results suggest that CPL agents were very chemotherapeutic for unresectable HCC.
Aoki
Y
Y
Second Dept. of Medicine, Kurume University School of Medicine.
Hirai
K
K
Yamashita
K
K
Noguchi
H
H
Sakai
T
T
Majima
Y
Y
Tanikawa
K
K
Inoue
H
H
Okano
Y
Y
Hitoshi
T
T
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004341:Drug Evaluation; D004621:Embolization, Therapeutic; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods; D007459:Iodized Oil / Q000008:administration & dosage* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000627:therapeutic use; D012074:Remission Induction; D013535:Suspensions; D000509:alpha-Fetoproteins / Q000378:metabolism
D010713:Phosphatidylcholines; D013535:Suspensions; D000509:alpha-Fetoproteins; D007459:Iodized Oil; D002945:Cisplatin