title: Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?
abstract: Lifetime probability density functions from single-channel recording are usually assumed to follow a multiexponential form. The amplitudes and rate constants for each exponential component are presumed to be independent. We have explored this assumption and have found a correlation between the amplitudes and the rate constants in certain cases. We examine this correlation and the possibility that other functional forms may also properly describe these distribution functions.
authors: Department of Pharmacology, New York State College of Veterinary Medicine Cornell University, Ithaca 14853.
authors: G L
authors: GL
authors: Millhauser
authors: E E
authors: EE
authors: Salpeter
authors: R E
authors: RE
authors: Oswald
mesh_terms: D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008962:Models, Theoretical
chemical_list: D007473:Ion Channels