title: [Intraoperative coagulation activity--a defined group of trauma surgery patients].
abstract: Analyses of blood coagulation in a defined group of patients before, during, and after trauma-surgery confirms an intraoperative trigger-mechanism, that causes postoperative thromboembolic complications. They also proof the correlation between extent of tissue-lesion and extent of triggering, this was previously presumed from the postoperative incidence of thromboembolic complications. Apart from the usual blood coagulation tests the following parameters where analysed: Factor VIII: C, Ristocetin-Co-factor, Factor Xa, AT III, TAT, Reptilase-time, tPA, D-dimers, and FPA. Simultaneously, it was shown, that a preoperative prophylaxis of thrombosis can prevent an intraoperative increase of Factor Xa, that plays a key role in postoperative thromboembolic complication. The increased intraoperative turnover of coagulation factors, which is necessary for physiologic blood coagulation, is not prevented.
authors: Abteilung für Blutgerinnungsstörungen, Chirurgischen Universitätsklinik Hamburg-Eppendorf, BRD.
authors: V
authors: V
authors: Tilsner
authors: B
authors: B
authors: Eifrig
authors: H
authors: H
authors: Schöntag
authors: H
authors: H
authors: Reuter
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D005169:Factor VIII / Q000032:analysis; D015951:Factor Xa / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D010447:Peptide Hydrolases / Q000032:analysis; D013514:Surgical Procedures, Operative; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014947:Wounds and Injuries / Q000150:complications / Q000503:physiopathology* / Q000601:surgery
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D005169:Factor VIII; D010447:Peptide Hydrolases; D015951:Factor Xa; D010959:Tissue Plasminogen Activator
vernacular_title: Intraoperative Gerinnungsaktivierung--Untersuchungen an einem definierten Patientengut der Unfallchirurgie.