[Recent developments in the biochemistry of hirudins].
The paper reviews both the isolation methods of native hirudin and the manufacturing process of recombinant hirudins as well as the primary structures of the different hirudin variants. Furthermore, the review presents an evaluation of current studies in the mechanisms of the antithrombin action of hirudin.
Walsmann
P
P
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
D000595:Amino Acid Sequence; D001777:Blood Coagulation; D006629:Hirudins / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D011994:Recombinant Proteins; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000378:metabolism
D006629:Hirudins; D011994:Recombinant Proteins; D013917:Thrombin
Neue Erkenntnisse zur Biochemie des Hirudins.