Neurokinin A-induced bronchial hyperresponsiveness to methacholine in Japanese monkeys.
The present study was designed to investigate whether neurokinin A (NKA) and substance P (SP) increase bronchial responsiveness to methacholine (MCh). Before and 1, 2, 3 and 4 weeks after three Japanese monkeys had inhaled 10(-8) M NKA and 10(-8) M SP for 2 min, bronchial responsiveness to inhaled MCh was evaluated. Pulmonary flow resistance (R1) and dynamic lung compliance (Cdyn) were used as pulmonary function tests. Dose-response curves of R1 to inhaled MCh were shifted to the left 1 to 4 weeks after NKA treatment, compared with that obtained before treatment. However, SP treatment did not change the R1 dose-response curve. Thus, bronchial responsiveness to MCh was increased by inhalation of 10(-8) M NKA in Japanese monkeys.
Tamura
G
G
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Sakai
K
K
Taniguchi
Y
Y
Iijima
H
H
Honma
M
M
Katsumata
U
U
Maruyama
N
N
Aizawa
T
T
Takishima
T
T
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008170:Lung Compliance / Q000187:drug effects; D008251:Macaca; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D015288:Neurokinin A / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D013997:Time Factors
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D013373:Substance P; D015288:Neurokinin A