Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system.
In the chick chorioallantoic membrane system heparin plus cortisone caused a marked depression in the rate of collagenous protein biosynthesis in vivo during inhibition of angiogenesis. This suggests that monitoring the rate of collagenous protein biosynthesis in the chick chorioallantoic membrane system can be used as a quantitative method for evaluating angiogenesis inhibitors.
Maragoudakis
M E
ME
Department of Pharmacology, University of Patras Medical School, Greece.
Sarmonika
M
M
Panoutsacopoulou
M
M
D000482:Allantois / Q000098:blood supply / Q000378:metabolism; D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D009389:Neovascularization, Pathologic
D006493:Heparin; D003094:Collagen; D006854:Hydrocortisone