title: Metabolism of fenfluramine to norfenfluramine in guinea-pigs.
abstract: After injection of fenfluramine into guinea-pigs, the N-dealkylated metabolite norfenfluramine was present in brain at higher concentrations and persisted longer than the parent drug, fenfluramine. Contrary to a claim in previous literature, the guinea-pig does metabolize fenfluramine to norfenfluramine, hence the ability of fenfluramine to cause acute and long-term depletion of brain 5-hydroxytryptamine in this species does not prove that fenfluramine, instead of nonfenfluramine, can produce these effects.
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors: R W
authors: RW
authors: Fuller
authors: H D
authors: HD
authors: Snoddy
authors: K W
authors: KW
authors: Perry
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000378:metabolism*; D006168:Guinea Pigs; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009642:Norfenfluramine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism
chemical_list: D009642:Norfenfluramine; D005277:Fenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid