[Effect of tonsillar macrophages on several immune functions].
Effect of tonsillar macrophages on IL2 responsiveness of T cells, IFN production, T cell proliferation and NK cell activity was studied. Human tonsillar mononuclear cells (TMNC) were purified by a two-step procedure which included depletion of plastic-adherent cells and rosetting with sheep blood cells. The production of IFN by enriched T cells (ETC) and IL2 responsiveness of ETC deprived of macrophages were decreased, whereas T cell proliferation in response to PHA stimulation, and NK cell activity in ETC were enhanced. These results imply that the IL2 responsiveness, IFN production, T cell proliferation and NK cell activity in ETC are influenced by macrophages.
Cai
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D000818:Animals; D002455:Cell Division; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D014066:Palatine Tonsil / Q000166:cytology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D007376:Interleukin-2; D007372:Interferons