Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig.
The interaction of threshold doses of bradykinin (BK) and substance P (SP) with acetylcholine (ACh)-induced bronchospasm was investigated in anaesthetized guinea-pigs. The two peptides potentiated the ACh-induced bronchospasm, an effect which did not seem to depend on prostaglandin release. On the other hand, vagotomy abolished the capacity of BK and SP to potentiate the ACh-induced bronchospasm. The present data suggest a possible involvement of BK and SP in the genesis of airway hyperreactivity.
Omini
C
C
Institute of Pharmacological Sciences, University of Milan, Italy.
Brunelli
G
G
Hernandez
A
A
Daffonchio
L
L
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000503:physiopathology; D016861:Cyclooxygenase Inhibitors; D004357:Drug Synergism; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D014628:Vagotomy
D016861:Cyclooxygenase Inhibitors; D013373:Substance P; D000109:Acetylcholine; D001920:Bradykinin; D007213:Indomethacin