[Immunohistologic alterations of epidermal cytokeratins following cryotherapy].
Based on investigations on common warts, we studied the effect of cryotherapy on the immunohistological detection of intermediate filaments (cytokeratin, vimentin/desmin, tubulin) and plasminogen activators of the urokinase type (uPA). The staining patterns of 3 anticytokeratins were markedly changed after cryotherapy. Two broad-spectrum antibodies showed decreased or no binding to tissue sections. In addition, we found a paradoxical reactivity of lower epidermal cells with a monoclonal antibody against cytokeratin 19. Our results are discussed with special reference to autoimmunity after cryotherapy.
Wollina
U
U
Klinik und Poliklinik für Hautkrankheiten, Bereich Medizin der Friedrich-Schiller-Universität Jena.
D003452:Cryosurgery; D003893:Desmin / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D012867:Skin / Q000473:pathology*; D014404:Tubulin / Q000032:analysis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D014860:Warts / Q000473:pathology / Q000601:surgery*
D003893:Desmin; D007381:Intermediate Filament Proteins; D014404:Tubulin; D014746:Vimentin; D007633:Keratins; D014568:Urokinase-Type Plasminogen Activator
Immunhistologische Alterationen epidermaler Zytokeratine nach Kryotherapie.