Modifications of gamma-glutamyl transpeptidase activity in duodenal mucosa of rats treated with different antiulcer drugs.
The activity of gamma-glutamyl transpeptidase (gamma-GT) in duodenal mucosa both in healthy rats and in rats experimentally ulcerated with indomethacin increases significantly after oral administration of pirenzepine as well as ranitidine but not after oral administration of sucralphate. These increase in gamma-GT activity may contribute to the cytoprotective effects already described for pirenzepine and ranitidine.
Muñoz-Arrebola
P
P
Departement of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Spain.
Madrid
J A
JA
Salido
G M
GM
Martinez de Victoria
E
E
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000378:metabolism; D004386:Duodenum / Q000201:enzymology; D005260:Female; D007213:Indomethacin; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D010890:Pirenzepine / Q000494:pharmacology; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013392:Sucralfate / Q000494:pharmacology; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000897:Anti-Ulcer Agents; D010890:Pirenzepine; D013392:Sucralfate; D011899:Ranitidine; D005723:gamma-Glutamyltransferase; D007213:Indomethacin