N-AgIB of poliovirus type 1: a discontinuous epitope formed by two loops of VP1 comprising residues 96-104 and 141-152.
Analysis of resistant mutants to neutralizing monoclonal antibodies revealed a discontinuous neutralization epitope on VP1 of poliovirus type 1, Mahoney. The epitope has the unique property of being also part of a sequential epitope within neutralization antigenic site I (N-AgI). It is formed by residues in the loop 96-104 connecting the B and C strand and in the loop 141-152 connecting the D and E strand of VP1. Because of strong analogy to neutralization immunogen IB (NImIB) of human rhinovirus 14 (HRV-14) we have called this site N-AgIB of poliovirus type 1.
Wiegers
K
K
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Federal Republic of Germany.
Uhlig
H
H
Dernick
R
R
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000032:analysis* / Q000235:genetics; D001483:Base Sequence; D002213:Capsid / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins; D000939:Epitopes / Q000032:analysis / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D017955:Poliovirus / Q000235:genetics / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics
D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; D012367:RNA, Viral; C442540:VP1 protein, Poliovirus