Ganglioside treatment: reduction of CNS injury and facilitation of functional recovery.
Increased attention has focused on the use of brain gangliosides as a treatment for brain injury. This review traces the progression of in vitro and in vivo research which led to studies which have demonstrated that ganglioside treatment can facilitate recovery after CNS damage in animal models (for example, lesions, transections, hypoxia, ischemia). Hypotheses regarding the ability of gangliosides to stimulate neuronal plasticity, modulate trophic factors and reduce injury processes are presented.
Karpiak
S E
SE
Department of Psychiatry, College of Physicians & Surgeons of Columbia University, New York, New York 10032.
Li
Y S
YS
Mahadik
S P
SP
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy; D001930:Brain Injuries / Q000188:drug therapy*; D005732:Gangliosides / Q000502:physiology / Q000627:therapeutic use*; D007473:Ion Channels / Q000502:physiology; D009416:Nerve Regeneration
D005732:Gangliosides; D007473:Ion Channels