title: [Primary neuroendocrine Merkel cell carcinoma of the skin].
abstract: A 78-year-old woman noticed a nodule on the dorsal aspect of the left lower leg which caused no symptoms but gradually increased in size. The raised, brown-red nodule, about 1.5 cm in diameter, was widely excised because malignancy was suspected. Light and electronmicroscopy revealed changes typical of Merkel-cell carcinoma. Immunohistochemistry demonstrated neuron-specific enolase and cytokeratin. No metastases were found. Together with Langerhans cells and melanocytes, Merkel cells belong to the three non-keratinocyte cell types of the epidermis.
authors: Universitäts-Hautklinik, Hamburg-Eppendorf.
authors: A
authors: A
authors: Brücks
authors: G
authors: G
authors: Schaeg
authors: H
authors: H
authors: Mensing
mesh_terms: D000368:Aged; D015266:Carcinoma, Merkel Cell / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008928:Mitochondria / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D007633:Keratins; D010751:Phosphopyruvate Hydratase
vernacular_title: Primäres neuroendokrines Merkel-Zell-Karzinom der Haut.