title: The effect of substance P (SP) infusion above the supraoptic nuclei of hypothalamus on the vasopressin content in the posterior pituitary lobe after haemorrhage in rats.
abstract: Dekanski's method was used to estimate the pressor activity of the extracts of the posterior pituitary lobe in anaesthetized rats, after the infusion of 0.9% NaCl solution above the supraoptic nuclei and haemorrhage in the amount of 1.5% of body weight or after the infusion of Substance P solution above the supraoptic nuclei and haemorrhage. It has been found that the vasopressin content in the posterior pituitary lobe decreased about 20% after the infusion of 0.9% NaCl solution and haemorrhage. The infusion of Substance P above the supraoptic nuclei inhibits the loss of vasopressin from the pituitary caused by haemorrhage.
authors: Department of Physiology, Institute of Physiology and Biochemistry, School of Medicine, Lódź.
authors: G
authors: G
authors: Rubacha
authors: M
authors: M
authors: Orłowska-Majdak
authors: W
authors: W
authors: Traczyk
mesh_terms: D000818:Animals; D006470:Hemorrhage / Q000503:physiopathology*; D007274:Injections, Intraperitoneal; D008297:Male; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D013373:Substance P