Products of class II major histocompatibility complex gene subregions are differentially expressed on keratinocytes in cutaneous diseases.
Aberrant expression of class II major histocompatibility complex (MHC) subregion antigens by keratinocytes was examined immunohistochemically in a range of cutaneous disorders. Although cell surface expression of human lymphocyte antigen (HLA)-DR was observed, HLA-DQ and HLA-DP were not expressed in any disorder investigated except for allergic contact dermatitis. Epidermal Langerhans cells expressed antigens of all three subregions on the cell surface. Differential expression of class II MHC subregion antigens may be related to tissue levels of gamma-interferon or to different functions of each subregion.
Barker
J N
JN
Laboratory of Applied Dermatopathology, United Medical School, Guy's Hospital, London, United Kingdom.
Ophir
J
J
MacDonald
D M
DM
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D006682:HLA-DP Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000276:immunology; D012867:Skin / Q000166:cytology; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*; D013194:Staining and Labeling
D000954:Antigens, Surface; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens