The effect of paraquat lung on mononuclear cells.
The mouse footpad swelling test was used to clarify the possibility of the induction of local cellular reaction with cell suspension of mouse lungs treated with paraquat in a syngeneous animal. Among the inbred strains used, the highest, statistically significant cellular reactivity was observed in C3H/He strain mice. These results suggest indirect evidence of macrophage activation in the lung toxicity of paraquat.
Barabás
K
K
Department of Hygiene and Epidemiology, University Medical School, Szeged, Hungary.
Serényi
P
P
Selypes
A
A
Matkovics
B
B
D000818:Animals; D006098:Granulocytes / Q000187:drug effects; D008168:Lung / Q000166:cytology* / Q000187:drug effects; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010269:Paraquat / Q000633:toxicity*; D013194:Staining and Labeling
D010269:Paraquat