Immunotherapy of experimental autoimmune encephalomyelitis (EAE): differential effect of anti-IL-2 receptor antibody therapy on actively induced and T-line mediated EAE of the Lewis rat.
Treatment of Lewis rats with monoclonal anti-interleukin-2 receptor (IL-2 R) antibody ART-18 is highly efficient in protecting the recipients from T-line transferred experimental autoimmune encephalomyelitis (tEAE) in vivo. In contrast, ART-18 did not affect the development of EAE actively induced (aEAE) by immunization with myelin basic protein (MBP) in complete Freund's adjuvant (CFA). ART-18 caused a slight delay in the development of aEAE only in combination with a subtherapeutic dose of cyclosporine A (Cy-A), but failed to influence duration or severity of clinical signs. The discrepancy in therapeutic efficiency of ART-18 in tEAE and aEAE could be due to a different intensity of IL-2 R-expression on in vitro- and in vivo-activated MBP-specific T cells. Our results therefore caution against a general therapeutic application of anti IL-2 R-directed therapy in all manifestations of T-cell-mediated autoimmunity.
Engelhardt
B
B
Max-Planck-Gesellschaft, Klinische Forschungsgruppe für Multiple Sklerose, Würzburg, FRG.
Diamantstein
T
T
Wekerle
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D005260:Female; D007114:Immunization; D007116:Immunization, Passive; D004676:Myelin Basic Protein / Q000633:toxicity; D051381:Rats; D011917:Rats, Inbred Lew / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000637:transplantation
D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D004676:Myelin Basic Protein; D015375:Receptors, Interleukin-2