title: Synthetic retinoids inhibit histamine release from isolated human mast cells.
abstract: In view of the immunomodulating properties of the synthetic retinoids etretinate and isotretinoin, their effects on isolated human mast cells were investigated. At concentrations of 10(-6) to 10(-5) M, isotretinoin and at 10(-6) M to 5 X 10(-5) M, etretinate inhibited concanavalin-A induced histamine release dose-dependently. Effective concentrations corresponded to achievable levels under therapeutic conditions in man. Without any additional stimulant, both drugs exhibited no appreciable effects with the exception of a toxic damage at very high levels.
authors: Department of Dermatology, University of Münster, FRG.
authors: D
authors: D
authors: Eichelberg
authors: W
authors: W
authors: Schmutzler
mesh_terms: D003208:Concanavalin A / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D005050:Etretinate / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D015474:Isotretinoin; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D003208:Concanavalin A; D014212:Tretinoin; D005050:Etretinate; D015474:Isotretinoin