[Antitumor effect of the Soviet recombinant alpha2-interferon (reaferon) under experimental conditions].
The antitumor and immunomodulating effect of reaferon was demonstrated in Syrian hamsters bearing tumors induced by cells transformed by HSV-1 DNA (the EH/A-44 strain). The animals received a total of 5 X 10(3) IU/ml of reaferon. In combined use of a lysate of destroyed tumor cells (DTC) and reaferon the best results were obtained with regard to an increase in the latent period of tumor development, differences in the tumor size, and increase in the survival time of the experimental animals as compared with the control group. In 75% of the animals given DTC and reaferon no tumors were observed up to 113 days. The above data suggest that reaferon may be recommended for combined therapy in malignant diseases where the etiologic factors might be viruses of the herpes group.
Lavrukhina
L A
LA
Posevaia
T A
TA
Barinskiĭ
I F
IF
Ershov
F I
FI
D000818:Animals; D002461:Cell Line, Transformed; D006224:Cricetinae; D004279:DNA, Viral / Q000378:metabolism; D007369:Interferon Inducers / Q000494:pharmacology; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007372:Interferons / Q000097:blood; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000628:therapy*; D011994:Recombinant Proteins
D004279:DNA, Viral; D007369:Interferon Inducers; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007372:Interferons
Protivoopukholevyĭ éffekt otechestvennogo preparata rekombinantnogo alpha2-interferona (reaferona) v éksperimente.