title: Combinations of monoclonal antibodies can distinguish primary lung tumors from metastatic lung tumors sampled by fine needle aspiration biopsy.
abstract: Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a selected panel of monoclonal antibodies (MoAb) to tumor-associated antigens (TAA) can improve the diagnostic potential of FNA, we have immunocytochemically analyzed 122 pulmonary CT-FNA. Whereas conventional cytology was capable of recognizing only the neoplastic nature of the lesions, the immunocytochemical diagnosis could identify the primary or metastatic nature of the pulmonary masses in 92.5% of the cases. The immunocytochemical findings were confirmed by clinical-histopathologic data. The current results demonstrate that the use of immunocytochemical methods can significantly improve the diagnostic accuracy of conventional cytology of lung masses.
authors: Regina Elena Cancer Institute, Rome, Italy.
authors: M
authors: M
authors: Mottolese
authors: I
authors: I
authors: Venturo
authors: M
authors: M
authors: Rinaldi
authors: N
authors: N
authors: Campioni
authors: A
authors: A
authors: Aluffi
authors: C G
authors: CG
authors: Curcio
authors: R P
authors: RP
authors: Donnorso
authors: P G
authors: PG
authors: Natali
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001707:Biopsy, Needle; D000939:Epitopes; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes