Triploid fetus: an important consideration in the evaluation of very high maternal serum alpha-fetoprotein.
Two patients referred for evaluation of very high maternal serum alpha-fetoprotein (10-20 multiples of the median) were carrying triploid fetuses with placentas showing features of partial hydatidiform mole. The diagnosis of fetal triploidy should be considered when there is a very high maternal serum alpha-fetoprotein and no ultrasound evidence of open neural tube defect, ventral wall defect, or any other explanation. Therefore, chromosomal analysis of amniotic fluid cells in such cases is essential.
Kazazian
L C
LC
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Baramki
T A
TA
Thomas
R L
RL
D000653:Amniotic Fluid / Q000032:analysis; D002869:Chromosome Aberrations; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics*; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D008431:Maternal-Fetal Exchange; D009030:Mosaicism; D011123:Polyploidy; D011247:Pregnancy; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins