Influenza A virus enhances allergic histamine release. Effect of neuraminidase.
Histamine release was examined in leukocyte suspensions from patients allergic to house dust mite, grass pollen, birch pollen or cat dander. Influenza A virus was found to enhance the antigen-induced mediator release, but did not cause release of histamine from the cells per se. Also histamine release induced by anti-IgE in cell suspensions from normal individuals was enhanced by virus. The potentiating effect of influenza A virus might be due to neuraminidase on the surface of virus, since a similar effect was caused by a purified neuraminidase obtained from Vibrio cholerae, and the effect of virus as well as the neuraminidase was completely abolished by a potent neuraminidase inhibitor. The synergistic enhancement in IgE-mediated histamine release by virus could be of significance for the conversion from latent to manifest asthma.
Clementsen
P
P
Dept. of Pharmacology, University of Copenhagen, Denmark.
Hannoun
C
C
Norn
S
S
D000328:Adult; D000485:Allergens; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D001491:Basophils / Q000276:immunology*; D004357:Drug Synergism; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology; D009980:Influenza A virus / Q000201:enzymology / Q000502:physiology*; D008875:Middle Aged; D009439:Neuraminidase / Q000494:pharmacology*
D000485:Allergens; D000956:Antigens, Viral; D007073:Immunoglobulin E; D009439:Neuraminidase