Alpha-fetoprotein and phagocytosis in athymic nude mice.
Alpha-fetoprotein (AFP) was found to suppress the phagocytic activity of the blood monocytes and neutrophils in vitro. The amounts of AFP detectable by immunofluorescence in the livers of nu/nu, nu/+ and +/+ mice were quite comparable, and thus could not have been responsible for the alterations in phagocytosis found in leukocytes of athymic nude mice during their ontogenetic development.
Vĕtvicka
V
V
Institute of Microbiology, Czechoslovak Academy of Science, Prague.
Holub
M
M
Kovárů
H
H
Siman
P
P
Kovárů
F
F
D000367:Age Factors; D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D000509:alpha-Fetoproteins / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology
D000509:alpha-Fetoproteins