title: Mechanisms of anesthesia-induced depression of myocardial function.
abstract: Anesthetics may depress myocardial function. Part of this action is due to a direct negative inotropic effect of these agents. With the increasing knowledge on the cardiac excitation-contraction process, the understanding of the different possible mechanisms, underlying the anesthetic-induced myocardial depression also increases. The present state of knowledge on these possible mechanisms is reviewed and they are discussed as to their relative importance and their clinical relevance.
authors: Department of Anesthesiology, University Hospital Antwerp, Edegem.
authors: S
authors: S
authors: De Hert
authors: H
authors: H
authors: Adriaensen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000777:Anesthetics / Q000494:pharmacology*; D003285:Contractile Proteins / Q000187:drug effects; D003864:Depression, Chemical; D006019:Glycolysis / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D012508:Sarcolemma / Q000187:drug effects
chemical_list: D000777:Anesthetics; D003285:Contractile Proteins; D007473:Ion Channels; D000255:Adenosine Triphosphate