[Changes in regional pulmonary hemodynamics and levels of vasoactive substances in man in a state of antiorthostatic hypokinesia].
A comparative evaluation of rheographic changes in regional pulmonary hemodynamics and renin-angiotensin and kinin-kallikrein activities was carried out on 9 volunteers exposed to antiorthostatic hypokinesia (-8 degrees) for 14 days. It was found that pulmonary circulation shifted in the apical direction due to increase in arterial tonicity and phasic variations of venous lumen. During the study blood renin increased significantly (P less than 0.05) whereas prekallikrein and kallikrein inhibitor varied insignificantly. It was concluded that the renin-angiotensin system played and important role in the changes of functional topography of pulmonary circulation in simulated microgravity conditions.
Vorob'ev
V E
VE
Kovachevich
I V
IV
Goncharov
I B
IB
Vinnitskiĭ
L I
LI
Egorova
I A
IA
D007611:Aprotinin / Q000097:blood*; D006439:Hemodynamics; D006801:Humans; D007103:Immobilization; D008297:Male; D011187:Posture; D011288:Prekallikrein / Q000097:blood*; D011652:Pulmonary Circulation; D012083:Renin / Q000097:blood*; D013997:Time Factors
D011288:Prekallikrein; D007611:Aprotinin; D012083:Renin
Izmeneniia regionarnoĭ legochnoĭ gemodinamiki i urovnia vazoaktivnykh veshchestv u cheloveka v usloviiakh antiortostaticheskoĭ gipokinezii.