Hemorrhagic bullous amyloidosis. A histologic, immunocytochemical, and ultrastructural study of two patients.
In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A lambda serum in both patients.
Bieber
T
T
Department of Dermatology, Ludwig-Maximilians University, Munich, West Germany.
Ruzicka
T
T
Linke
R P
RP
von Kries
R
R
Goerz
G
G
Braun-Falco
O
O
D000368:Aged; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007124:Immunoenzyme Techniques; D012867:Skin / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000473:pathology*; D013194:Staining and Labeling
D000682:Amyloid