Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel.
Dihydropyridines (+)-PN200-110 and (+/-)-Bay-K-8644 inhibit or potentiate, respectively, catecholamine release evoked by DMPP- or K-stimulation of perfused cat adrenal glands. Since both, secretion of adrenaline and noradrenaline are equally affected, and these two drugs specifically act on voltage-dependent chromaffin Ca channels, it seems that secretion of each amine from their respective cell is regulated by the same type of channel.
Cárdenas
A M
AM
Department of Pharmacology, Universidad Autónoma de Madrid, Facultad de Medicina, Spain.
Montiel
C
C
Esteban
C
C
Borges
R
R
García
A G
AG
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D004095:Dihydropyridines / Q000494:pharmacology*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004837:Epinephrine / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D017275:Isradipine; D009638:Norepinephrine / Q000378:metabolism*; D010069:Oxadiazoles / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012016:Reference Values
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D007473:Ion Channels; D010069:Oxadiazoles; D004246:Dimethylphenylpiperazinium Iodide; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine; D017275:Isradipine