[The role of ubiquinones in regulating lipid metabolism in rat thymocytes].
The effects of ubiquinones Q-1, Q-2, Q-8 and Q-9 on lipid biosynthesis in thymocytes in vitro were studied during incubation of cells with ubiquinones within the concentration range of 1-100 mM. A 2-fold inhibition of cholesterol synthesis in thymocytes by ubiquinone Q-9 occurred, when the exogenous ubiquinone concentration in the medium was no less than 40 mM. Incubation of thymocytes with unrelated ubiquinone (Q-1 and Q-2-40 and 100 mM, respectively) resulted in the inhibition of cholesterol synthesis. The inhibiting effect was of the same order of magnitude as that during incubation with ubiquinone Q-9. Ubiquinone Q-8 showed a tendency to inhibit cholesterol synthesis in rat thymocytes. The inhibiting effect of ubiquinone on cholesterol metabolism in thymocytes is specific and is not coupled with fatty acid metabolism.
Novoselova
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EG
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism*; D014498:Uracil / Q000378:metabolism
D000085:Acetates; D005227:Fatty Acids; D008055:Lipids; D014451:Ubiquinone; D014498:Uracil; D012313:RNA; D002784:Cholesterol
Rol' ubikhinonov v reguliatsii lipidnogo obmena v timotsitakh krys.