The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children.
Haematological indices and red cell folate levels (RCF) were measured during two annual surveys in a group of Gambian children aged 3 months-5 years who were participating in a trial of malaria chemoprophylaxis with Maloprim or chlorproguanil given with or without folate supplements. Chlorproguanil was given in an adult dose of 20 mg, Maloprim as one quarter or one half of the adult dose of 25 mg pyrimethamine and 100 mg dapsone. Antimalarials and folate supplements were given fortnightly. About 20% of children had low RCF levels (less than 100 ng/ml). Among children who did not receive supplementation with folate there were no significant differences in mean RCF levels between children who received Maloprim, chlorproguanil or placebo. Among children who received folate supplements, the mean RCF was significantly lower among those receiving chlorproguanil than among the controls. Mean RCF values were similar in children who received Maloprim or placebo. If chlorproguanil is used for malaria chemoprophylaxis in young children an age-related dose should be used.
Fuller
N J
NJ
Medical Research Council Dunn Nutrition Unit, Cambridge, U.K.
Bates
C J
CJ
Hayes
R J
RJ
Bradley
A K
AK
Greenwood
A M
AM
Tulloch
S
S
Greenwood
B M
BM
D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D002675:Child, Preschool; D003622:Dapsone / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects*; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005714:Gambia; D006400:Hematocrit; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D010919:Placebos; D002727:Proguanil / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D011739:Pyrimethamine / Q000008:administration & dosage / Q000494:pharmacology
D000962:Antimalarials; D004338:Drug Combinations; D010919:Placebos; C001678:Maloprim; C007030:chlorproguanil; D003622:Dapsone; D005492:Folic Acid; D002727:Proguanil; D011739:Pyrimethamine