Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis.
A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain longitudinal profiles recapitulating fetal exposure. Logit and hockey-stick models as well as nonparametric smoothing are used to describe data on delayed development and central nervous system abnormality.
Cox
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Division of Biostatistics, University of Rochester School of Medicine, New York 14642.
Clarkson
T W
TW
Marsh
D O
DO
Amin-Zaki
L
L
Tikriti
S
S
Myers
G G
GG
D001939:Bread; D002490:Central Nervous System / Q000187:drug effects; D002658:Developmental Disabilities / Q000209:etiology; D005260:Female; D005506:Food Contamination; D006197:Hair / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007493:Iraq; D008431:Maternal-Fetal Exchange; D008767:Methylmercury Compounds / Q000506:poisoning*; D008962:Models, Theoretical; D011247:Pregnancy; D012307:Risk Factors; D013052:Spectrometry, X-Ray Emission / Q000379:methods
D008767:Methylmercury Compounds