A model of the gating of ion channels.
The gating of ion channels in biological membranes has usually been described in terms of Markov transitions between a few discrete open or closed states. Such models predict that the distributions of open and closed durations decay as a sum of exponential terms. Recent experimental data have indicated that certain channels are not easily described by these models. We show that distributions of open and closed times similar to those seen experimentally are predicted by a model that involves only one open and closed state but that assumes the activation energy of the gating process to be stochastic. This model involves only a few parameters and these have direct physical interpretations. Measurements of the correlation between the durations of successive open or closed events is shown to provide an experimental method for distinguishing between this and other models.
Croxton
T L
TL
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis 46223.
D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological
D007473:Ion Channels