title: Antibodies in human serum that precipitate ribonuclease P.
abstract: Sera from certain patients with systemic lupus erythematosus (SLE) and related rheumatic diseases contain antibodies that selectively deplete extracts of HeLa cells of RNase P activity. Most of the sera that recognize RNase P, an endoribonuclease with an essential RNA subunit, also contain antibodies against another small ribonucleoprotein known as the Th antigen. A species of RNA about 400 nucleotides in length is the only RNA species found in common in all immunoprecipitates prepared with anti-RNase P antibodies. The discovery of antibodies against RNase P defines a major class of antibodies produced by patients with autoimmune disease.
authors: Department of Biology, Yale University, New Haven, CT 06520.
authors: H A
authors: HA
authors: Gold
authors: J
authors: J
authors: Craft
authors: J A
authors: JA
authors: Hardin
authors: M
authors: M
authors: Bartkiewicz
authors: S
authors: S
authors: Altman
mesh_terms: D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D002848:Chromatography, DEAE-Cellulose; D004722:Endoribonucleases / Q000276:immunology* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007118:Immunoassay; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D012313:RNA / Q000276:immunology*; D043262:Ribonuclease P; D012261:Ribonucleoproteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D012261:Ribonucleoproteins; D012313:RNA; D004722:Endoribonucleases; C468368:RPP14 protein, human; D043262:Ribonuclease P