Dextran-magnetite: a contrast agent for sodium-23 MRI.
Dextran-magnetite, a superparamagnetic compound, is a powerful relaxation reagent for sodium. Administered intravenously, it is confined mainly to the vasculature and eliminates the signal from plasma sodium, a significant component of the tissue sodium signal. Applications of dextran-magnetite for in vivo sodium imaging of a normal rat and rats with a tumor and experimentally induced peripheral edema are shown. Our results indicate that dextran-magnetite may be useful for improving tumor detection and for imaging of edema. To our knowledge, this is the first report of a contrast agent suitable for sodium magnetic resonance imaging.
Summers
R M
RM
Pendergrass Diagnostic Radiology Research Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Joseph
P M
PM
Renshaw
P F
PF
Kundel
H L
HL
D000230:Adenocarcinoma / Q000175:diagnosis; D000818:Animals; D003911:Dextrans; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood
D003911:Dextrans; D012964:Sodium