Vitronectin is phosphorylated by a cAMP-dependent protein kinase released by activation of human platelets with thrombin.
Activation of freshly isolated human platelets with a physiological stimulant (thrombin) causes them to release a cAMP-dependent protein kinase which specifically phosphorylates one plasma protein (Mr 75000). This protein is immunochemically and biochemically identified as vitronectin (also know as S protein), which was previously implicated in blood clotting, complement function and cell adhesion.
Korc-Grodzicki
B
B
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Tauber-Finkelstein
M
M
Chain
D
D
Shaltiel
S
S
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002852:Chromatography, Ion Exchange; D000242:Cyclic AMP / Q000494:pharmacology*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008970:Molecular Weight; D009994:Osmolar Concentration; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000097:blood*; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology*; D019096:Vitronectin
D006023:Glycoproteins; D047428:Protein Kinase Inhibitors; D019096:Vitronectin; D008345:Manganese; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D011494:Protein Kinases; D013917:Thrombin; D008274:Magnesium