20 KDa homologous restriction factor of complement resembles T cell activating protein.
We previously identified a 20KDa membrane glycoprotein 1F5 antigen which inhibits the assembly of homologous complement membrane attack complexes and we designate it as HRF20 standing for 20KDa homologous restriction factor. The amino acid sequence deduced from its coding base sequence resembles that of T cell activating protein, most conspicuously in cysteine residues, 10 out of 11 of which occupy identical positions in an overall sequence homology of 24.8%. Furthermore, proliferation of human T cells was stimulated by monoclonal antibody to HRF20.
Okada
H
H
Department of Molecular Biology, Nagoya City University School of Medicine, Japan.
Nagami
Y
Y
Takahashi
K
K
Okada
N
N
Hideshima
T
T
Takizawa
H
H
Kondo
J
J
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000502:physiology*; D004247:DNA / Q000235:genetics; D006801:Humans; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D008970:Molecular Weight; D015183:Restriction Mapping; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex; D008562:Membrane Glycoproteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D003165:Complement System Proteins; D004247:DNA