[Biological markers in hepatocellular carcinoma].
Primary cancer of the liver, especially common in inter-tropical Africa and South-East Asia, still remains inaccessible to a really effective therapy, except for a rapid surgical excision. Improvement of its particularly poor prognosis requires therefore early screening based on reliable biological markers. Following alpha-feto-protein, various parameters have been proposed: enzyme, ferritin, desialylated serum protein, decarboxylated prothrombin... However, alpha-feto-protein remains, in practice, the reference diagnostic test, in spite of a moderate specificity below 500 ng/ml and the fact that it is frequently missing in early cancers. Its diagnostic score may be improved either by the use of monoclonal antibodies, or by determining the ratio of fucosylated form, or by concomitant use of other markers: alpha-L-fucosidase, decarboxy-prothrombin.
Deugnier
Y
Y
Laboratoire d'Anatomie et de Cytologie pathologiques et Clinique des maladies du foie, Rennes.
David
V
V
Leray
G
G
Blayau
M
M
Le Gall
J Y
JY
D000911:Antibodies, Monoclonal; D001212:Asialoglycoproteins / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000201:enzymology; D003653:Decarboxylation; D005293:Ferritins / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D011516:Prothrombin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis / Q000276:immunology
D000911:Antibodies, Monoclonal; D001212:Asialoglycoproteins; D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; D011516:Prothrombin; D005293:Ferritins
Les marqueurs biologiques du carcinome hépato-cellulaire.