[Clinico-pathological study of solid poorly differentiated carcinoma of the stomach].
We have studied the clinico-pathological features of 42 autopsied cases involving solid, poorly differentiated carcinomas that histologically revealed a medullary growth pattern but none showing a tubular formation. Ninety percent of these 42 cases were male, and the 42 carcinomas were of 5 histological types as listed below: 1) small cell carcinoma-atypical carcinoid type (15 cases); 2) AFP-producing type (so-called "hepatoid carcinoma") (4 cases); 3) acinar type (8 cases); 4) signet ring cell-medullary type (2 cases); and, 5) large cell type (13 cases) The small cell carcinoma-atypical carcinoid type, the AFP-producing type, and the large cell type showed a severe hematogenous metastasis. In contrast, the acinar type had a lymphogenous metastasis the signet ring cell-medullary type, showed a lymphogenous and peritoneal metastasis. Each histological type well corresponded to the typical biological characteristics of each of these carcinomas of the stomach.
Maruyama
M
M
Div. of Surgery, Tokyo Metropolitan Komagome Hospital.
Kitamura
M
M
Arai
K
K
Yoshikawa
T
T
Kosaki
G
G
Takizawa
T
T
Koike
M
M
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D013274:Stomach Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis / Q000096:biosynthesis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins