Childhood neurological morbidity and its association with gestational age, intrauterine growth retardation and perinatal stress.
Data from 7-year-old children (n = 5363) enrolled prenatally during the 1960s in the Boston sector of the National Collaborative Perinatal Project (NCPP) have been used to study the associations of abnormal neurological findings at 7 years of age with gestational age, intrauterine growth-retardation (IUGR) and hypoxia-related perinatal stress. Among infants without perinatal stress, pre-term infants were at higher risk of abnormal neurological findings at 7 years than were term and post-term infants. IUGR infants, in the absence of stress, were not at any increased risk relative to non-IUGR infants. The odds ratio associated with perinatal stress increased with gestational age and was greater in the IUGR than in the non-IUGR infants.
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Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut.
D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005317:Fetal Growth Retardation; D005311:Fetal Hypoxia; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015337:Multicenter Studies as Topic; D011247:Pregnancy; D011446:Prospective Studies