The role of organic synthesis in glycoconjugate research: selected examples.
Chemical synthesis of various oligosaccharides allowed the determination of structural requirements for specific interaction between heparin and anti-thrombin III. The synthesis of a sialylated tetrasaccharide, subunit of the human blood group Cad determinant, is also reported.
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Ecole Normale Supérieure, Laboratoire de Chimie, UA1110, Paris, France.
D000990:Antithrombin III; D001665:Binding Sites; D001789:Blood Group Antigens / Q000276:immunology; D000939:Epitopes; D006001:Glycoconjugates / Q000138:chemical synthesis*; D006493:Heparin / Q000138:chemical synthesis; D006801:Humans; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D001789:Blood Group Antigens; D000939:Epitopes; D006001:Glycoconjugates; D009844:Oligosaccharides; D000990:Antithrombin III; D006493:Heparin