Study of the antiallergic component of inosine pranobex (Inosiplex, Isoprinosine).
Inosine pranobex (INPX) at concentrations greater than 10(-3) M inhibits significantly the concanavalin A or antihuman IgE induced histamine release from human mast cells. The inosine moiety of the compound does not contribute to this effect, but rather interferes with it. The other component, the salt of dimethylaminopropanol and acetamidobenzoic acid, produces a small but significant inhibition of the histamine release already at 10(-6) M. This effect is due to the acetamidobenzoic acid although the base (dimethylaminopropanol) adds to it. With increasing incubation time, the salt of dimethylaminopropanol and acetamidobenzoic acid looses its histamine release inhibiting effect.
Schmutzler
W
W
Institut für Pharmakologie, Medizinische Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, FRG.
Neukirch
B
B
Ziesche
R
R
D003208:Concanavalin A / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects*; D013329:Structure-Activity Relationship
D003208:Concanavalin A; D007288:Inosine; D007542:Inosine Pranobex