NK-1 receptors mediate the tachykinin stimulation of salivary secretion: selective agonists provide further evidence.
The relative contribution of NK-1, NK-2 and NK-3 receptors to the sialogogic response to i.v. tachykinins was investigated in urethane-anesthetized rats. [Pro9,Met(O2)11]substance P (SP), a selective NK-1 receptor agonist, was about 10 times more potent than SP itself and its action was unaffected by atropine pretreatment. On the other hand [Nle10]neurokinin A (NKA)-(4-10) and [MePhe7]neurokinin B (NKB), two selective agonists for NK-2 and NK-3 receptors, respectively, were ineffective.
Giuliani
S
S
Pharmacology Department Research Laboratories, A. Menarini Pharmaceuticals, Florence, Italy.
Maggi
C A
CA
Regoli
D
D
Drapeau
G
G
Rovero
P
P
Meli
A
A
D000818:Animals; D008297:Male; D015288:Neurokinin A; D015287:Neurokinin B; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012472:Salivation / Q000187:drug effects*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D015320:Tachykinins
D009479:Neuropeptides; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D015320:Tachykinins; C057104:substance P, Pro(9)-Met(O2)(11)-; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B