Effects of THA on ionic currents in myelinated axons of Xenopus laevis.
In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system.
Elinder
F
F
Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.
Mohammed
A K
AK
Winblad
B
B
Arhem
P
P
D000609:Aminoacridines / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D009186:Myelin Sheath / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D013619:Tacrine / Q000494:pharmacology*; D014982:Xenopus laevis
D000609:Aminoacridines; D007473:Ion Channels; D013619:Tacrine; D011189:Potassium Chloride