Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.
Ishikawa
F
F
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Miyazono
K
K
Hellman
U
U
Drexler
H
H
Wernstedt
C
C
Hagiwara
K
K
Usuki
K
K
Takaku
F
F
Risau
W
W
Heldin
C H
CH
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D002633:Chemotaxis; D002642:Chick Embryo; D003001:Cloning, Molecular; D004247:DNA; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009389:Neovascularization, Pathologic; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D014407:Tumor Cells, Cultured
D010982:Platelet-Derived Growth Factor; D004247:DNA