title: Regulation of ornithine decarboxylase from Mycobacterium smegmatis.
abstract: The activity of ornithine decarboxylase in Mycobacterium smegmatis is regulated by a novel macromolecular inhibitor--a ribonucleic acid. Addition of polyamines to the growth medium enhances the level of this inhibitor, suggesting that the level of this negative modulator changes in response to the intracellular concentration of polyamines. Thus, while other modes of regulation may be operational, the control by polyamines at the transcriptional level leading to the generation of a specific RNA inhibitor seems to be a key element in the regulation of ornithine decarboxylase in mycobacteria.
authors: Department of Biochemistry, Vallabhbhai Patel Chest Institute, Delhi, India.
authors: D
authors: D
authors: Balasundaram
authors: A K
authors: AK
authors: Tyagi
mesh_terms: D001426:Bacterial Proteins / Q000302:isolation & purification / Q000502:physiology*; D003850:Deoxyribonuclease I; D003956:Dialysis; D004355:Drug Stability; D019286:Endopeptidase K; D004789:Enzyme Activation / Q000187:drug effects; D007700:Kinetics; D009161:Mycobacterium / Q000201:enzymology* / Q000254:growth & development; D065108:Ornithine Decarboxylase Inhibitors; D012313:RNA / Q000037:antagonists & inhibitors; D012697:Serine Endopeptidases
chemical_list: D001426:Bacterial Proteins; D065108:Ornithine Decarboxylase Inhibitors; D012313:RNA; D003850:Deoxyribonuclease I; D012697:Serine Endopeptidases; D019286:Endopeptidase K