[A new animal model for intravesical chemotherapy of bladder cancer].
A new animal model for intravesical chemotherapy of bladder cancer was prepared by transplanting BC-47 cells into the bladder wall of syngenic ACI/N rat and later transurethral cauterization of the urothelium covering the developed solid tumor, and compared with two common models. One of the models was prepared by similarly transplanting the tumor cells without further treatment and another by transurethral instillation of the tumor cells into cauterized bladder. Tumor transplantation and denudation were both 100% successful in the new model and was superior to those in two common models. The new model was more sensitive to peplomycin than the common model prepared by transplanting the tumor cells into bladder wall without cauterization of the urothelium, while the sensitivity to adriamycin were practically the same as that of the common model. This difference may be due to presence of the urothelium, which seemed to inhibit a contact of intravesically administered peplomycin with tumor. It could be considered that the new model with denuded tumor has a high predictivity on the clinical effect for drug candidates.
Yamashita
T
T
Ito
J
J
D000283:Administration, Intravesical; D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D009368:Neoplasm Transplantation; D017663:Peplomycin; D051381:Rats; D011912:Rats, Inbred ACI; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
D001761:Bleomycin; D017663:Peplomycin; D004317:Doxorubicin