Physiology of granulocyte and macrophage colony-stimulating factors in host defense.
The colony-stimulating factors (CSF) are a family of glycoprotein hormones that regulate the proliferation and maturation of hematopoietic progenitor cells. In addition to their effects on hematopoiesis, CSFs modulate the function of fully mature cells and, therefore, play an important role in regulating inflammatory responses vital to host defense. Here we review recent information that describes the biological activity of the CSFs on mature cell function, including chemotaxis, adherence, motility, phagocytosis, oxidative metabolism, and cytotoxicity.
Weisbart
R H
RH
Division of Rheumatology, VA Medical Center, Sepulveda, California.
Golde
D W
DW
D000818:Animals; D001685:Biological Factors / Q000502:physiology; D003115:Colony-Stimulating Factors / Q000494:pharmacology / Q000502:physiology*; D016207:Cytokines; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008222:Lymphokines / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor; D010586:Phagocytes / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects
D001685:Biological Factors; D003115:Colony-Stimulating Factors; D016207:Cytokines; D006133:Growth Substances; D008222:Lymphokines; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor