Development of monoclonal antibody imaging of metastatic prostatic carcinoma.
Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody were determined. Based on these findings we are hopeful that modifications of this radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.
Meyers
F J
FJ
Department of Internal Medicine, Davis Medical Center, University of California, Sacramento.
Denardo
S J
SJ
Macey
D
D
White
R D
RD
Unger
M
M
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000276:immunology*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011467:Prostate / Q000000981:diagnostic imaging / Q000276:immunology; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen