title: Review of acid phosphatase in the diagnosis and prognosis of prostatic cancers.
abstract: Acid phosphatase is a secretory product frequently utilized as a tumor marker for disseminated, late stage (D2) prostatic cancer. In the 40 years since this association has been recognized, this enzyme has been subjected to extensive biochemical and immunological characterizations. These techniques have also been adapted for rapid and specific determinations of the prostatic isoenzyme levels using a variety of techniques. Since acid phosphatase levels do not become significantly elevated until late stage cancer, newer markers such as prostate-specific antigen have been sought which appear earlier and may be more useful for the screening and monitoring of high risk populations. At this time it is appropriate to review the current and future status of acid phosphatase as a diagnostic aid.
authors: Department of Research Biochemistry, Hektoen Institute for Medical Research, Chicago, Ill.
authors: M
authors: M
authors: Rubenstein
authors: P D
authors: PD
authors: Guinan
authors: C F
authors: CF
authors: McKiel
authors: A
authors: A
authors: Dubin
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis* / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor; D006801:Humans; D008297:Male; D011379:Prognosis; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D011863:Radioimmunoassay
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen