[The effect of somatostatin on pancreatic enzyme secretion in rats in vivo and in vitro].
Authors investigated the inhibitory effect of somatostatin on pancreatic enzyme secretion in vivo and in vitro, in rats. In conscious animals somatostatin strongly inhibited pancreatic amylase secretion. In vitro, however, amylase secretion was not affected by the peptide: it had no affect either on basal secretion, or on stimulated secretion induced via CCK-, or cholinergic receptors. Furthermore, it did not modify nerve-stimulation induced enzyme secretion. The results suggest that the in vivo inhibitory action somatostatin on pancreatic enzyme secretion is an indirect one.
Varga
G
G
Papp
M
M
Solomon Travis
E
E
D000681:Amylases / Q000378:metabolism; D000818:Animals; D004791:Enzyme Inhibitors; D066298:In Vitro Techniques; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D013004:Somatostatin; D000681:Amylases
Somatostatin hatása patkányok pancreasának enzimelválasztására in vivo és in vitro.