[Chemosensitivity of human head and neck tumors detected by human tumor clonogenic assay].
Chemosensitivity of human head and neck tumor was evaluated by human tumor clonogenic assay. Among eight of head and neck tumors seven squamous cell carcinomas such as tongue, gingiva, maxillary sinus, pharynx and one malignant fibrous histiocytoma (MFH) of maxillary sinus and four anti-cancer agents BLM, CDDP, 5-FU and MMC were used. Five of eight tumors were succeeded to evaluate the sensitivity. Positive rates except MFH were BLM 100% (3/3), CDDP 25% (1/4), 5-FU 33% (1/3). These results are similar to recent clinical experiments except CDDP.
Suzuki
K
K
Fujii
M
M
Ishii
Y
Y
Mochizuki
F
F
Suzuki
K
K
Yamagata
M
M
Suzuki
H
H
Moriya
Y
Y
Abiko
Y
Y
Sakabe
T
T
D001761:Bleomycin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy*; D006801:Humans; D008937:Mitomycins / Q000627:therapeutic use*; D014410:Tumor Stem Cell Assay
D008937:Mitomycins; D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil