Adhesives in larynx repair.
Guinea pig laryngeal fractures were used as a model to compare the ease of application and effectiveness of the fibrinogen-adhesive system with the ease of application and effectiveness of cyanoacrylate glue and control fractures stinted with contralateral gelatin film. Seven fibrin adhesive-treated and two cyanoacrylate glue-treated guinea pigs were perfused after 60 and 35 days, respectively. The larynges were serial sectioned, and the wound sites were compared. The fibrinogen adhesive system was easier to dispense than cyanoacrylate glue, did not require a completely dry surface, and stabilized within 3 minutes. Cartilage segment alignment with focal, complete fracture healing and symmetrical chondrocyte proliferation were seen in fibrogen adhesive-stinted larynges. In the cyanoacrylate glue-treated larynges, there was no alignment and minimal, asymmetrical chondrocyte proliferation. Gelatin film-stinted controls exhibited similar features. Thus, fibrogen adhesive was easier to apply and more effectively bound laryngeal fractures than cyanoacrylate glue or gelatin film.
Lyons
M B
MB
Department of Otorhinolaryngology and Biocommunication, Louisiana State University School of Medicine, New Orleans 70112.
Lyons
G D
GD
Webster
D
D
Wheeler
V R
VR
D000818:Animals; D007611:Aprotinin; D003487:Cyanoacrylates; D004338:Drug Combinations; D005176:Factor XIII; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D050723:Fractures, Bone / Q000628:therapy*; D005780:Gelatin; D006168:Guinea Pigs; D007830:Larynx / Q000293:injuries*; D013917:Thrombin; D014014:Tissue Adhesives; D014945:Wound Healing
D003487:Cyanoacrylates; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; C015233:gelatin film; C029054:ethyl 2-cyanoacrylate; D005780:Gelatin; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin