Molecular mechanisms of associative learning in mammal and mollusc.
Recent work in this laboratory has begun to cast light on the biochemical mechanisms by which a cell stores associatively acquired information. This appears to occur principally via two general pathways. The first seems to be a long-term activation of protein kinase C (resulting in long-term alterations in protein phosphorylation) while the second involves changes in RNA synthesis. One striking aspect of these mechanisms in that they seem to be conserved across the species we have studied (rabbit and Hermissenda). In the present paper we review some of the studies that support the role of protein kinase C activation and RNA synthesis in memory formation.
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Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Nelson
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Alkon
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D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D004789:Enzyme Activation; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D008974:Mollusca; D011493:Protein Kinase C / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013045:Species Specificity
D012313:RNA; D011493:Protein Kinase C