title: Regression of cardiac hypertrophy after antihypertensive therapy with nifedipine and captopril.
abstract: The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N and C induced a significant reduction in end-diastolic, but not systolic, posterior wall and septum thickness and an increase in end-diastolic volume, but not in end-systolic volume. A significant increase in the contribution of rapid filling together with a simultaneous reduction in the contribution of atrial systole to end diastolic volume were also observed. The reduction in LV wall thickness and mass after both C and N might be attributed to an improvement in diastolic function and to a reduction in wall tension, rather than to an effective regression of LV hypertrophy.
authors: Istituto di Clinica Medica, Università di Verona, Italy.
authors: I
authors: I
authors: Sheiban
authors: G
authors: G
authors: Arcaro
authors: G
authors: G
authors: Covi
authors: R
authors: R
authors: Accardi
authors: C
authors: C
authors: Zenorini
authors: A
authors: A
authors: Lechi
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002216:Captopril / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000150:complications*; D004452:Echocardiography; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects*; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007090:Image Interpretation, Computer-Assisted; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
chemical_list: D002216:Captopril; D009543:Nifedipine