Decreased SP-stimulated diesteratic hydrolysis of inositol phospholipids in adrenal medulla slices from spontaneously hypertensive rats.
The effects of substance P on inositol phospholipids of adrenal medulla slices from spontaneously hypertensive and normotensive Wistar-Kyoto rats were investigated. Substance P reduces [32P] incorporation into inositol phospholipids of both rat strains. This effect was most expressed in hypertensive rats, which showed a higher basal 32P incorporation into phosphatidylinositol phosphates compared to normotensive control rats (probably due to the higher turnover of monoester-phosphate groups). Substance P causes a less potent diesteratic hydrolysis of [3H]inositol prelabelled phospholipids in spontaneously hypertensive rats compared with Wistar-Kyoto rats. A possible consequence of the reduced diesteratic hydrolysis by endogenous substance P and related substances of inositol phospholipids in adrenal medulla from spontaneously hypertensive rats is discussed.
Minenko
A
A
Institute of Drug Research, Academy of Sciences of the GDR, Berlin.
Gabrysiak
B
B
Oehme
P
P
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D006868:Hydrolysis; D006973:Hypertension / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013373:Substance P / Q000494:pharmacology*
D010710:Phosphates; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D010761:Phosphorus Radioisotopes; C037178:phosphatidylinositol 4-phosphate; D013373:Substance P; D007294:Inositol