Interaction of hexachlorocyclohexane (HCH) and chlorpropham (CIPC) in male rats.
Hexachlorocyclohexane (60.0 mg/kg/d) and chlorpropham (50.0 mg/kg/d) given to male rats daily orally for 30 d caused subtle biochemical lesions. The significant rise in the activity of alkaline phosphatase in liver and serum and of GOT and GPT in liver with substantial weight increase of liver has been suggestive of the initiation of biochemical lesions and adaptation of the organism. Very severe hepatocellular damage is forecasted if the pesticides are given for a prolonged period and in higher concentrations to animals.
Dikshith
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TS
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Carrera
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Raizada
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RB
Mitjavila
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S
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D002748:Chlorpropham / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006540:Herbicides / Q000633:toxicity*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats
D006540:Herbicides; D002748:Chlorpropham; D001556:Hexachlorocyclohexane; D000469:Alkaline Phosphatase