title: Influence of ventricular fibrillation duration on defibrillation energy in dogs using bidirectional pulse discharges.
abstract: The automatic implantable defibrillator device typically discharges 5-30 seconds after detection of ventricular fibrillation. To investigate the importance of the duration of ventricular fibrillation on defibrillation, the effects of ventricular fibrillation durations of 5, 15, and 30 seconds on the energy requirements for successful internal defibrillation were compared in 15 closed chest dogs with internal electrodes. The electrode configuration utilized a transvenous right heart catheter with two electrodes and a precordial subcutaneous patch electrode, with a single bidirectional pulse discharged between the distal catheter electrode and the proximal catheter and patch electrodes. Curves of energy vs. percentage of successful defibrillation were constructed and logistic regression was used to derive 90% and 50% successful energy doses (ED90 and ED50). The mean ventricular fibrillation activation interval just prior to defibrillation was determined from discrete RV endocardial electrograms. Four dogs died during testing, all because of inability to defibrillate after 30 s of ventricular fibrillation. In the remaining 11 dogs, the ED90 increased from (mean +/- SD) 27 +/- 13J at 5 s to 41 +/- 14J at 30 s (p less than .01). The mean ventricular fibrillation activation interval decreased from 107 +/- 21 ms at 5 s to 95 +/- 18 ms at 30 s (p less than .01). In conclusion, the energy required for internal defibrillation in dogs using this electrode configuration increases with longer durations of ventricular fibrillation, and is associated with more rapid ventricular fibrillation activation intervals.
authors: Department of Medicine, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
authors: D S
authors: DS
authors: Echt
authors: J T
authors: JT
authors: Barbey
authors: J N
authors: JN
authors: Black
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006328:Cardiac Catheterization / Q000295:instrumentation; D004285:Dogs; D004554:Electric Countershock / Q000295:instrumentation / Q000379:methods*; D004562:Electrocardiography; D004567:Electrodes, Implanted; D004867:Equipment Design; D010138:Pacemaker, Artificial; D019736:Prostheses and Implants; D011897:Random Allocation; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000503:physiopathology*