Angiogenesis induction by CD-4 positive lymphocytes.
Adult splenocytes from BALB/c mice, labeled with a monoclonal antibody directed against the L3T4 (CD-4) differentiation antigen, were sorted to obtain pure suspensions of this T-cell subset. When inoculated intradermally into irradiated, semi-allogeneic adult animals these cells were found to be the effector cells responsible for the lymphocyte-induced angiogenesis. The experiments demonstrate that the CD-4 lymphocyte subset is primarily or entirely responsible for this immune-mediated elicitation of the host neovascular reaction.
Kaminski
M
M
Laboratory of Developmental Biology, University of Wisconsin, Madison 53706.
Auerbach
R
R
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D005434:Flow Cytometry; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte