Standard models of corneal injury using alkali-immersed filter discs.
Central corneal alkali burn injuries were induced in rabbits by applying five NaOH concentrations on uniformly soaked 7 mm filter paper discs. Clinical parameters were evaluated daily by microscopic examination and photography, and corneal myeloperoxidase levels were measured periodically. Satisfactory alkali burn models of corneal inflammation, vascularization and ulceration were developed by manipulating the alkali concentration.
Ormerod
L D
LD
Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
Abelson
M B
MB
Kenyon
K R
KR
D000468:Alkalies; D000818:Animals; D002057:Burns, Chemical / Q000150:complications; D003315:Cornea / Q000098:blood supply / Q000473:pathology; D015715:Corneal Edema / Q000209:etiology; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000209:etiology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005374:Filtration / Q000295:instrumentation; D007634:Keratitis / Q000209:etiology; D009389:Neovascularization, Pathologic / Q000473:pathology; D010209:Paper; D011817:Rabbits
D000468:Alkalies