Effect of acyl chain length on the structure and motion of gramicidin A in lipid bilayers.
The transmembrane ion transport properties of gramicidin A have previously been shown to dependent on the nature of its lipid environment. Solid-state NMR spectroscopic studies of 13C-labelled analogues of gramicidin in oriented multilayers of phosphatidylcholine have shown that variation of the lipid hydrocarbon chain length has no effect on the structure or orientation of the peptide backbone.
Cornell
B A
BA
Australian Membrane and Biotechnology Research Institute, CSIRO Division of Food Processing, Sydney.
Separovic
F
F
Thomas
D E
DE
Atkins
A R
AR
Smith
R
R
D002247:Carbon Isotopes; D006096:Gramicidin; D008051:Lipid Bilayers; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship
D002247:Carbon Isotopes; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D006096:Gramicidin