[125I]endothelin-1 binding sites: autoradiographic studies in the brain and periphery of various species including humans.
Quantitative autoradiography with [125I]-endothelin-1 (ET-1) has been used to localize putative ET-1 recognition sites in the brain and peripheral organs of various species including humans. High densities of high-affinity [125I]ET-1 binding sites were observed in heart, lung, liver, kidney, blood vessels, and brain. A differential pattern of distribution of ET-1 recognition sites was observed in the periphery and in the brain, indicating that putative ET-1 receptors are not located only in blood vessels. The data are consistent with a role for ET-1 in vascular smooth muscle and nonvascular tissues, such as heart, lung, intestine, kidney, and brain.
Hoyer
D
D
Preclinical Research, Sandoz Ltd., Basel, Switzerland.
Waeber
C
C
Palacios
J M
JM
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D016232:Endothelins; D000882:Haplorhini; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine
D016232:Endothelins; D007457:Iodine Radioisotopes; D010455:Peptides; D011956:Receptors, Cell Surface