Effect of dextran on the stability of isolated, perfused rat heart.
Stability of cardiac function and myocardial intracellular ionic composition was examined in the Krebs-perfused isolated rat working heart. Hearts perfused by a conventional Krebs solution showed stable contraction for 2 h, but during this period, intracellular ionic environment (Na, K, Ca) substantially changed. Addition of dextran to the perfusate inhibited, though not completely, this time-dependent deterioration and made the heart less vulnerable to the hypoxia-reoxygenation.
Okada
T
T
Department of Physiology, Juntendo University School of Medicine, Tokyo, Japan.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003911:Dextrans / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007552:Isotonic Solutions; D008297:Male; D008970:Molecular Weight; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D003911:Dextrans; D007552:Isotonic Solutions; C051865:Krebs-Ringer solution; D012964:Sodium; D011188:Potassium; D002118:Calcium