Nimodipine's effect on alcohol disposition in mice.
Adult Binghamton Heterogeneous male mice received either nimodipine (5 mg/kg in saline) or vehicle 10 minutes prior to ethanol (1.02 g/kg) administration. Blood samples were obtained at 2, 10, 30, 60 and 120 minutes following the alcohol injection for determination of ethanol content. Although mean blood alcohol concentrations (BACs) were similar for both groups, nimodipine increased the variance in blood alcohol levels. Therefore, while nimodipine may alter alcohol pharmacokinetics through its interaction(s) with the genetic characteristics of the individual animal, the ability of this calcium slow channel blocking agent to enhance the psychotropic effects of alcohol cannot be due to altered absorption or elimination of the intoxicant.
Gilliam
D M
DM
Department of Psychology, State University of New York, Albany 12222.
Isaacson
R L
RL
Burright
R G
RG
Johnston
J E
JE
Fahey
J M
JM
Vargas
D
D
D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000431:Ethanol / Q000493:pharmacokinetics*; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D009553:Nimodipine / Q000494:pharmacology*
D007473:Ion Channels; D000431:Ethanol; D009553:Nimodipine; D002118:Calcium