Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries.
The effects of a DA1 dopamine receptor selective agonist, fenoldopam, were examined on human blood vessels. Fenoldopam relaxed precontracted human arteries in vitro from brachial, cerebral, cervical, colic, coronary, lumbar, pulmonary, renal and splenic sites. Fenoldopam failed to relax uterine or external iliac arteries or saphenous vein segments. These effects of fenoldopam were not endothelium dependent, but were antagonised by the selective DA1 receptor antagonists, SCH 23390, (+)-butaclamol, and (R)- more than (S)-sulpiride. The effect of fenoldopam may involve cyclic adenosine monophosphate. These studies indicate the presence of DA1 receptors on a variety of large isolated human arteries.
Hughes
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Department of Clinical Pharmacology, St. Mary's Hospital Medical School, London, UK.
Sever
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D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D001552:Benzazepines / Q000494:pharmacology*; D002069:Butaclamol / Q000494:pharmacology; D002648:Child; D000242:Cyclic AMP / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004730:Endothelium, Vascular / Q000502:physiology; D018818:Fenoldopam; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D013469:Sulpiride; D002069:Butaclamol; D000242:Cyclic AMP; D018818:Fenoldopam; D015056:1-Methyl-3-isobutylxanthine