[Is there a preference among fibrin glues for nerve anastomosis?].
Although fibrin glues have been successful in many areas of surgery, they have not become fully established in nerve anastomosis, even in ENT surgery, an area where significant advantages were expected. As the fibrin clot dissolves prematurely, and dehiscences follow, antifibrinolytic substances must be added to the adhesive. Fibrosis often complicates the use of nerve adhesives. We examined both adhesive systems for their ability to induce fibrosis and their regenerative success rate. Using 1000 KIU aprotinin and 4 IU thrombin there was no significant difference on the effect of both commercially available fibrin adhesives on the collagen content of a nerve anastomosis or on the cumulative action potential in the rat. The proportion of connective tissue was about 33%. Regeneration was undoubtedly recorded.
Herter
T
T
Neurochirurgische Klinik und Poliklinik, Westfälischen Wilhelms-Universität Münster.
D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009416:Nerve Regeneration; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery; D013917:Thrombin / Q000008:administration & dosage*; D014014:Tissue Adhesives / Q000627:therapeutic use*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin
Gibt es eine Präferenz bei den Fibrinklebern für die Nervenanastomosierung?