Acute and chronic effects of dihydropyridines on triglycerides in humans.
Several drugs used in the treatment of hypertension have been shown to affect lipid metabolism. A few studies have examined in detail the effects of calcium antagonists on blood lipids. We investigated the effects of nifedipine and nitrendipine on blood lipids using two experimental protocols. The first study was a double-blind, randomized, placebo-controlled trial to assess the effects of acute oral administration of nifedipine 10 mg on blood lipids in 10 patients (9 males, 1 female; age range 26-50 years) with mild hypertriglyceridemia. Serum triglycerides were not significantly affected (from 310 +/- 120 to 280 +/- 110 mg/dl 2 h after nifedipine) but a slight decrease was observed in patients with higher baseline levels. In the second study, an intravenous fat tolerance test (ivFTT, Intralipid 10%, 1 ml/kg body weight, as a bolus) was performed before and after chronic oral administration of nitrendipine 10 mg b.i.d. in 10 mild to moderate hypertensive patients (7 males, 3 females; age range 40-60 years). After nitrendipine treatment, the fractional removal rate (K2) of the lipid emulsion was significantly increased from 3.1 +/- 0.9 to 3.8 +/- 0.9% min (p less than 0.05). The main findings of these studies suggest that the secretion of lipoprotein lipase might be stimulated by calcium antagonists. Alternatively, the vasodilation produced by these compounds may influence triglyceride removal by expanding the capillary bed where the enzyme exerts its activity. In conclusion, calcium antagonists do not seem to cause unwanted side effects on blood lipids and apparently enhance triglyceride removal.
Pasanisi
F
F
Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy.
Marotta
T
T
Ferrara
L A
LA
Gnasso
A
A
Cortese
C
C
Mancini
M
M
D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use; D009568:Nitrendipine / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D014280:Triglycerides; D009568:Nitrendipine; D009543:Nifedipine