Type I reactions directed against Pneumocystis carinii in AIDS patients.
Type I allergy directed against Pneumocystis carinii (PC) has been investigated in 14 patients with AIDS. The Pneumocystis carinii pneumonia often shows a rapid and severe course, and type I allergy against the parasite might be a pathogenic co-factor in the interstitial lung inflammation. In twelve of the AIDS patients the clinical symptoms and course of illness indicated a PC pneumonia. The basophil histamine release test was used as a sensitive test to detect type I allergy against PC. Eight of the patients showed significant histamine release when stimulated with PC. In contrast, only two patients in the group of 12 HIV antibody-positive homosexual men and none in the control group of 13 heterosexual men released histamine. The histamine release was mediated by an immunological reaction, since the release was abolished and regained by removal from and refixation to the cell surface of the cell-bound immunoglobulins before the antigen challenge. The results suggest an involvement of type I allergy as a pathogenic co-factor in Pneumocystis carinii pneumonia.
Pedersen
M
M
Laboratory of Immunology, University Clinic for Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
Nielsen
P B
PB
Permin
H
H
Norn
S
S
Mojon
M
M
Skov
P S
PS
Faber
V
V
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011010:Pneumocystis / Q000276:immunology*
D007073:Immunoglobulin E; D000001:Calcimycin