Routine maternal serum alpha-fetoprotein measurement in 210 pregnancies.
Of 210 maternal serum samples none had alpha-fetoprotein (AFP) level above the mean and 22 (10.4%) had a level under the mean; of these, 21 had maternal serum AFP levels within normal limits upon repeat sampling within 1-2 weeks of the original evaluation. When low AFP values are interpreted in order to identify women at risk of carrying a fetus with Down's syndrome, obstetricians should be aware of high incidence of false positive at the first assay.
Garzarelli
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D000328:Adult; D015415:Biomarkers / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D000509:alpha-Fetoproteins