Oxygen delivery and demand in conscious pigs subjected to fixed-volume hemorrhage and resuscitated with 7.5% NaCl in 6% Dextran.
A conscious porcine model was used to investigate the adequacy of O2 delivery relative to O2 demand, initially during a fixed-volume hemorrhage (37.5 ml/kg over 1 hr) and subsequently after resuscitation with 7.5% NaCl/6% Dextran 70 (4 ml/kg). Hemorrhage produced a small increase in O2 consumption, severe lactacidemia, and a doubling of apparent O2 demand. These effects were attributable to a behavioral compensation (periodic bouts of muscle activity) which presumably served to improve venous return. Despite enhanced ventilatory function, arterial O2 delivery was markedly reduced by hemorrhage, an effect that was due entirely to decrements in cardiac output and hemoglobin level. The disparity between O2 delivery and O2 demand was lessened following resuscitation with 7.5% NaCl/6% Dextran 70, primarily by suppression of demand and secondarily by an augmentation of delivery.
Hannon
J P
JP
Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129.
Wade
C E
CE
Bossone
C A
CA
Hunt
M M
MM
Loveday
J A
JA
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage*; D010100:Oxygen / Q000378:metabolism*; D012151:Resuscitation / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000378:metabolism* / Q000628:therapy; D013552:Swine
D003911:Dextrans; D012462:Saline Solution, Hypertonic; D010100:Oxygen