Transmembrane channels based on tartaric acid-gramicidin A hybrids.
The gramicidin A transmembrane channel is believed to consist of two head-to-head beta helices. Computer-generated models were used to formulate the structure of new single-chain channel molecules based on the gramicidin motif. The chemical synthesis of two tartaric acid-gramicidin A hybrids and single-channel analyses of their conducting properties are reported. These studies illustrate the rational design and synthesis of long-lived channels with tunable conductance properties and provide support for current molecular models of the natural (dimeric) gramicidin channel.
Stankovic
C J
CJ
Heinemann
S H
SH
Delfino
J M
JM
Sigworth
F J
FJ
Schreiber
S L
SL
D000595:Amino Acid Sequence; D003198:Computer Simulation; D004553:Electric Conductivity; D006096:Gramicidin / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011487:Protein Conformation; D055503:Protein Multimerization; D013644:Tartrates / Q000378:metabolism*; D013816:Thermodynamics
D007473:Ion Channels; D046911:Macromolecular Substances; D013644:Tartrates; D006096:Gramicidin; C029768:tartaric acid