Experimental studies in animals on the use of a fibrin glue from the human plasma fraction Cohn I in nerve reconstruction.
In order to compare the effects of suture and glue direct nerve connections and nerve transplantations in the sciatic nerve in rats were performed. 4, 6 and 12 weeks later, the nerve anastomosis were histologically studied. In the direct nerve connections, despite a single holding suture, dehiscences were frequently detected with the penetration of the adhesive between the nerve ends. Due to the exact adaptation with the aid of inserted nerve grafts, the anastomoses could be repaired sutureless successfully using a fibrin glue cuff. Since histologically, in comparison to suture, no foreign body granulomas were found, the findings in the literature could be confirmed. No cicatricial contractions of the anastomoses could be found. In the interfascicular nerve transplantation, comparatively good results may be obtained using the two-component adhesive on the Cohn I-fraction basis.
Hamm
K D
KD
Department of Neurosurgery, Medical Academy Erfurt, GDR.
Steube
D
D
Pothe
H
H
Beer
R
R
D000714:Anastomosis, Surgical; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001798:Blood Proteins / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D006801:Humans; D008866:Microsurgery; D009416:Nerve Regeneration / Q000187:drug effects*; D010949:Plasma / Q000032:analysis*; D051381:Rats; D012584:Sciatic Nerve / Q000601:surgery; D013537:Sutures; D013917:Thrombin / Q000627:therapeutic use*
D001798:Blood Proteins; C047487:Cohn fraction I; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin