title: Inhibition of cAMP increase by an anti-allergic agent, NCO-650, during histamine release.
abstract: Antigen and concanavalin A (Con A) induced an increase in cAMP and histamine release from rat peritoneal mast cells. In a dose-dependent manner, the compound, NCO-650, significantly inhibited both the initial and secondary increases in cAMP stimulated by antigen, anti-IgE and Con A in rat peritoneal mast cells. IC50 values of NCO-650 for cAMP increase stimulated by antigen, anti-IgE and Con A were 3.8, 3.4 and 2.8 microM, respectively.
authors: Department of Pharmacology, Tokushima Bunri University, Japan.
authors: M
authors: M
authors: Takei
authors: T
authors: T
authors: Matumoto
authors: K
authors: K
authors: Endo
authors: M
authors: M
authors: Muramatu
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
chemical_list: D000888:Antibodies, Anti-Idiotypic; D003509:Cyclohexanecarboxylic Acids; D003208:Concanavalin A; D007073:Immunoglobulin E; C038303:NCO 650; D000242:Cyclic AMP