[Effect of prazosin on human prostatic adenoma tissue].
The effect of prazosin on epinephrine-induced contractions of human benign prostatic hyperplasia strips was studied. It was shown that prazosin has a pronounced adrenoblocking activity (EC50 = 5.10(-9) g/ml) but fails to affect strip contractions induced by KCL. It is suggested that prazosin can be used in the treatment of patients suffering from benign prostatic hyperplasia.
Kaminka
M E
ME
Zhirnikova
M L
ML
Vinarov
A Z
AZ
Mashkovskiĭ
M D
MD
Pytel'
Iu A
IuA
D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011224:Prazosin / Q000627:therapeutic use*; D011467:Prostate / Q000187:drug effects; D011470:Prostatic Hyperplasia / Q000188:drug therapy*
D011224:Prazosin
Vliianie prazozina na tkan' adenomy predstatel'noĭ zhelezy cheloveka.