Effects of glycosaminoglycan polysulphate in the treatment of chondrocalcinosis.
The effect of intra-articular injections of glycosaminoglycan polysulphate (Arteparon) on pain, joint mobility, inflammatory reactions, cartilage calcification and the urinary excretion of inorganic pyrophosphate was studied in 12 patients with chondrocalcinosis. All cases were bilateral and the less affected homologous joint served as an untreated control. The patients were followed over a one-year period. The glycosaminoglycan polysulphate treatment brought about a significant reduction of pain (p less than 0.01) and improvement of joint mobility (p less than 0.001). This effect continued for the whole one-year follow-up period, but could not be seen in the control joints. After the treatment period of 2-7 weeks there was a marked decrease in cartilage calcification paralleled with an increase in the excretion of inorganic pyrophosphate.
Sarkozi
A M
AM
Department of Rheumatology, Central Hospital of Hungarian State Railways, Budapest.
Nemeth-Csoka
M
M
Bartosiewicz
G
G
D000328:Adult; D000368:Aged; D001168:Arthritis / Q000150:complications / Q000188:drug therapy; D002805:Chondrocalcinosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D011756:Diphosphates / Q000652:urine; D005260:Female; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D009068:Movement; D010166:Palliative Care; D010653:Phenylbutazone / Q000627:therapeutic use; D011859:Radiography
D011756:Diphosphates; D006025:Glycosaminoglycans; C013786:A73025; D010653:Phenylbutazone