title: Genetic and tissue-specific variation in the expression of a closely linked murine multigene family on chromosome 15 that encodes salivary and lacrimal proteins.
abstract: The murine submandibular gland (SMG) produces a novel class of highly acidic salivary proteins encoded by one or more highly abundant mRNA transcripts. In inbred mice, these transcripts are encoded by members of a multigene family comprising approximately 8-12 homologues. Most, and probably all, of these homologues are clustered at a new locus near belted (bt) on chromosome 15, which we designate Spt (salivary protein). Although physically closely linked, Spt genes differ in their patterns of expression both in strains of mice and in their tissues. One gene, Spt-1, is expressed at high levels in the SMG of all inbred strains examined. This gene is also expressed at significant levels in the lacrimal gland. A second gene, Spt-2, appears to be present as a single copy in some strains and as two copies in others. This gene is expressed at high levels only in the SMG of those strains carrying two copies, and Spt-2 mRNA is not detectable in the SMG of strains carrying only one copy. In contrast to Spt-1, the Spt-2 gene is not expressed at detectable levels in the lacrimal gland.
authors: Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263.
authors: D P
authors: DP
authors: Dickinson
authors: K
authors: K
authors: Abel
authors: J
authors: J
authors: Near
authors: B A
authors: BA
authors: Taylor
authors: K W
authors: KW
authors: Gross
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D005796:Genes; D008040:Genetic Linkage; D014644:Genetic Variation; D006822:Hybrid Cells / Q000378:metabolism; D015151:Immunoblotting; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D005810:Multigene Family; D009928:Organ Specificity; D010641:Phenotype; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000235:genetics; D012471:Salivary Proteins and Peptides / Q000235:genetics*; D013045:Species Specificity; D013363:Submandibular Gland / Q000378:metabolism; D013666:Tears / Q000032:analysis*
chemical_list: D011506:Proteins; D012471:Salivary Proteins and Peptides; D012313:RNA; D004247:DNA