title: Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome.
abstract: Injection of rabbits with a human T cell line infected with HIV-1 caused seroconversion within 6 wk, and HIV-1 could be isolated from PBL cultures of infected rabbits. Identity of the isolated virus with HIV-1 was shown by analysis of products amplified by the polymerase chain reaction. HIV-1 infection was seen in rabbits injected with HIV-1-infected cells alone as well as in those that were first infected with HTLV-1 and subsequently with HIV-1. There were no consistent signs of disease in the rabbits infected with HIV-1 alone but HTLV-1/HIV-1-infected rabbits showed signs of illness including diarrhea and weight loss, transient neurologic impairment and, in one animal, a rapidly progressing mammary adenocarcinoma. Examination of organs taken at necropsy from both HIV-1- and HTLV-1/HIV-1-infected animals showed splenic hyperplasia and lymphocyte infiltration of the lungs, as well as moderate damage to liver and kidney in some cases.
authors: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892.
authors: H
authors: H
authors: Kulaga
authors: T
authors: T
authors: Folks
authors: R
authors: R
authors: Rutledge
authors: M E
authors: ME
authors: Truckenmiller
authors: E
authors: E
authors: Gugel
authors: T J
authors: TJ
authors: Kindt
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D004195:Disease Models, Animal; D006679:HIV Seropositivity / Q000503:physiopathology; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
chemical_list: D004279:DNA, Viral; D012194:RNA-Directed DNA Polymerase