[Study on allergic and non-allergic mechanisms in preventing asthma using a kidney-reinforcing regimen].
The onset of asthma involves the non-allergic mechanism as well as the allergic mechanism. Based on the markedly effectiveness in the prevention of the asthmatic attack with Wen Yang Pill [WYP, a prescription of Kidney-reinforcing regimen (KRR)], the authors investigated its mechanism in the endocrinologic and immunologic aspects and found that WYP could regulate the function of the hypothalamus-pituitary-adrenocortical axis and inhibit the seasonal increasement of the serum IgE level in the attack season through the improvement of the function of suppressor T cell. For further study, the authors observed the specific IgE level and the histamine release simultaneously induced by the same allergen the dust mite extraction. A positive relationship was seen between the specific IgE level and the histamine release in their differences before and after the treatment. The histamine inhalation test showed that the PC20 value and beta-receptor function of the lymphocyte of the controls were furtherly decreased in the anaphase of the attack season, while those of the WYP group were slightly increased in the same phase. The major pathological linkage were not all the same in the asthma patients and these patients had various manifestations. Since WYP could act on the main linkages of the allergic (IgE, mediator release) and non-allergic (immune regulation, beta-receptor function, endocrine function) mechanism, it could be available for the asthma patients with the different manifestations and make them get rid of the vicious circle of the asthmatic attack. In the way, it could relieve or suspend the seasonal attack.(ABSTRACT TRUNCATED AT 250 WORDS)
Shen
Z Y
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D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D000242:Cyclic AMP / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets; D007073:Immunoglobulin E; D000242:Cyclic AMP