Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze.
The effect of intraventricular administration of the neuropeptide galanin on acquisition and retrieval in a modified Morris swim maze was studied in rats. Galanin induced a significant deficit in the acquisition of the task while no effects on the retrieval were observed. No deficits were seen 24 h after the last treatment. Galanin did not increase the number of failures to reach the platform. It is suggested that endogenous galanin modulates learning possibly via the galanin-containing cholinergic neurons in the septum-basal forebrain area projecting to the hippocampus and cortex.
Sundström
E
E
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Archer
T
T
Melander
T
T
Hökfelt
T
T
D000818:Animals; D019004:Galanin; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior / Q000187:drug effects*; D013550:Swimming
D010455:Peptides; D019004:Galanin