The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
Nineteen obese female subjects with body mass index ranging between 30 and 40 were included in a double-blind crossover study aimed at evaluating the effects of oral 5-hydroxytryptophan administration on feeding behavior, mood state and weight loss. Either 5-hydroxytryptophan (8 mg/kg/day) or placebo was administered for five weeks during which patients were not prescribed any dietary restrictions. Feeding behavior was investigated by means of a questionnaire designed to establish the onset of anorexia and related symptoms. Food intake was evaluated using a three-day diet diary. BDI, SI, STAI-T, and STAI-S were used to assess mood state. The administration of 5-hydroxytryptophan resulted in no changes in mood state but promoted typical anorexia-related symptoms, decreased food intake and weight loss during the period of observation.
Ceci
F
F
Department of Internal Medicine, University of Rome La Sapienza, Italy.
Cangiano
C
C
Cairella
M
M
Cascino
A
A
Del Ben
M
M
Muscaritoli
M
M
Sibilia
L
L
Rossi Fanelli
F
F
D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D009765:Obesity / Q000188:drug therapy*
D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan