[Protective action of cytotoxic lymphocytes depending on the antigenic determinant composition of influenza virus hemagglutinin].
The protective role of cytotoxic lymphocytes (CTL) in dependence on composition of antigenic determinants of hemagglutinin of influenza viruses H3N2 was studied. It was established that CTL do not exert protective effect under conditions of adoptive transfer, when there is one common antigenic determinant in hemagglutinins of the virus forming immunity. When all antigenic determinants in hemagglutinins of influenza viruses are identical, CTL-like antibodies represent one of the main factors of antivirus immunity.
Berdinskikh
M S
MS
Kiseleva
A S
AS
Kosiakov
P N
PN
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000939:Epitopes; D006389:Hemagglutinins, Viral / Q000276:immunology*; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000517:prevention & control; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral
Protektivnoe deistvie tsitotoksicheskikh limfotsitov v zavisimosti ot sostava antigennykh determinant gemaggliutinina virusa grippa.