Biotransformation of chlordecone by Pseudomonas species.
1. Six-month chlordecone enrichment cultures with added chlordecone yielded several Gram-negative micro-organisms that were resistant to and/or degraded chlordecone. 2. Three Pseudomonas spp. were further characterized for their chlordecone degrading ability. 3. Chlordecone and two derivatives, Mirex and Kelevan, supported growth of these strains. 4. All three Pseudomonas spp. decreased the concentration of chlordecone in the medium after 14 days incubation, as determined by h.p.l.c. analysis when it was added either as sole carbon source or in the presence of medium supplements.
George
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Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Claxton
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D001711:Biotransformation; D007631:Chlordecone / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology; D007306:Insecticides / Q000493:pharmacokinetics*; D008917:Mirex / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects / Q000378:metabolism*
D003470:Culture Media; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; C001178:kelevan; D007631:Chlordecone; D008917:Mirex