The role of ultrasonography and amniocentesis in the evaluation of pregnancies at risk for neural tube defects.
To assess the relative efficacy of amniocentesis versus targeted (detailed) ultrasonography, 225 patients referred because of an elevated maternal serum alpha-fetoprotein level (79.6%) or a family history of neural tube defect (20.4%) were evaluated. Ultrasonographic examination alone detected all 26 fetal abnormalities (11 cases of anencephaly, 10 cases of open spina bifida, and five other anomalies). Twenty-eight patients declined amniocentesis; all had normal pregnancy outcomes. Of the 167 patients with apparently normal fetal anatomy by sonography, seven had elevated alpha-fetoprotein levels but no acetylcholinesterase in the amniotic fluid. Six of these pregnancies resulted in normal infants; one infant had congenital nephrosis. The remaining 160 patients had normal sonograms with normal amniotic fluid alpha-fetoprotein levels and no fetal malformations at delivery. Although these results suggest that targeted ultrasonography by experienced personnel is a reasonable alternative to amniocentesis in evaluations for neural tube defects, the availability, cost-effectiveness, and diagnostic accuracy of this approach must be well documented in large prospective studies.
Hogge
W A
WA
Department of Obstetrics and Gynecology, University of Virginia, Charlottesville 22908.
Thiagarajah
S
S
Ferguson
J E
JE
Schnatterly
P T
PT
Harbert
G M
GM
D000110:Acetylcholinesterase / Q000032:analysis; D000649:Amniocentesis / Q000592:standards; D005260:Female; D006801:Humans; D009401:Nephrosis / Q000151:congenital / Q000175:diagnosis; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013673:Technology Assessment, Biomedical; D014463:Ultrasonography / Q000592:standards; D014768:Virginia; D000509:alpha-Fetoproteins / Q000378:metabolism
D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase