Fibreoptic bronchoscopy: an assessment of immediate cytological diagnosis using methylene blue stain.
A method of examining cytological material during fibreoptic bronchoscopy using a methylene blue (MB) stain was assessed in 164 consecutive fibreoptic bronchoscopies where cytology specimens were taken. The MB method provided an immediate positive diagnosis in 86% of bronchoscopically visible tumours. Subsequent histology provided a positive diagnosis in 69%, conventional brush cytology in 81% and trap cytology in 77%. The MB method produced no false positive diagnosis of malignancy and the tumour cell type identified by MB stain agreed with the histological cell type in 72% of cases. This technique is considered to be sufficiently specific to provide a method of controlling the quality of specimens taken at bronchoscopy, for further analysis in the laboratory.
Titley
I
I
Regional Cell Pathology Service, Wandle Valley Hospital, Mitcham Junction, Surrey, U.K.
Davidson
R N
RN
Turner
E
E
Hicks
E R
ER
Cooke
N T
NT
Landells
W N
WN
Levene
M M
MM
D001984:Bronchial Neoplasms / Q000175:diagnosis*; D001999:Bronchoscopy / Q000379:methods*; D003581:Cytodiagnosis / Q000379:methods*; D005336:Fiber Optic Technology; D006801:Humans; D008751:Methylene Blue; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013194:Staining and Labeling
D008751:Methylene Blue