title: [A comprehensive laboratory evaluation of changes in the fibrinogen molecule in the diagnosis of acquired coagulopathy conditions].
abstract: A scheme of physicochemical determination of fibrinogen and the major molecular derivatives in a single sample of plasma is suggested, available for the majority of clinical laboratories. Such determination gives valuable information for a clinician. Among other things, the level of rapidly thrombin clotted fibrinogen portion is determined, as is the content of high-molecular fibrin monomer complexes, not clotted with thrombin, and the level of fibrinogen and fibrin proteolytic degradation products. Clinical (in 42 patients with various conditions) and experimental (coagulopathy in amniotic fluid embolism) application of this scheme has confirmed its clinico-diagnostic value.
authors: V A
authors: VA
authors: Siatkovskiĭ
authors: L A
authors: LA
authors: Azarova
authors: P L
authors: PL
authors: Vasilenko
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D005337:Fibrin / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008968:Molecular Conformation
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Kompleksnaia laboratornaia otsenka prevrashcheniĭ molekuly fibrinogena v diagnostike priobretennykh koagulopaticheskikh sostoianiĭ.