Dexamethasone inhibition of phagocytosis by corneal keratocytes in culture.
To investigate the effect of steroid hormone on phagocytosis by keratocytes, we investigated the phagocytic activities for latex beads by rabbit corneal keratocytes cultured in the presence and absence of dexamethasone. Culturing the corneal keratocytes with dexamethasone inhibited the phagocytic activity for latex beads in a dose-dependent fashion. The inhibitory effects depended on the duration of the incubation period of the cells with dexamethasone.
Mishima
H
H
Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan.
Nishida
T
T
Otori
T
T
D000818:Animals; D002478:Cells, Cultured; D003315:Cornea / Q000166:cytology*; D003907:Dexamethasone / Q000494:pharmacology*; D004728:Endothelium, Corneal / Q000166:cytology; D004847:Epithelial Cells; D007633:Keratins; D010587:Phagocytosis / Q000187:drug effects*
D007633:Keratins; D003907:Dexamethasone