title: Immunologic study of human encephalitic and paralytic rabies. Preliminary report of 16 patients.
abstract: Lymphocyte proliferation tests to rabies antigen and myelin basic protein were performed on peripheral blood lymphocytes from nine patients with the encephalitic form and on seven with the paralytic form of human rabies. Six of the nine patients with encephalitis had proliferative responses to rabies antigen, whereas all of the patients with paralysis had no response. Two patients in each group also had a proliferative response to myelin basic protein. The myelin basic protein-reactive patients had a more rapidly fatal disease than the non-reactive patients. This preliminary study suggests that host immune responses may influence the clinical manifestations and course in human rabies.
authors: Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
authors: T
authors: T
authors: Hemachudha
authors: P
authors: P
authors: Phanuphak
authors: B
authors: B
authors: Sriwanthana
authors: S
authors: S
authors: Manutsathit
authors: K
authors: K
authors: Phanthumchinda
authors: W
authors: W
authors: Siriprasomsup
authors: C
authors: C
authors: Ukachoke
authors: S
authors: S
authors: Rasameechan
authors: S
authors: S
authors: Kaoroptham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D004660:Encephalitis / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000276:immunology; D010243:Paralysis / Q000209:etiology / Q000276:immunology*; D011818:Rabies / Q000150:complications / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D004676:Myelin Basic Protein