Retrovirus in multiple sclerosis.
Presence of cytopathic effect and enzyme reverse transcriptase in cultures of peripheral blood mononuclear cells is described in 2 of 15 patients with multiple sclerosis and none of healthy controls. These findings might indicate: the presence of a new human retrovirus in these individuals, despite the low detection rate, and the shortcomings inherent in methodology used for detection of known human retroviruses in the study of new groups of diseases, such as those with possible autoimmune background.
Kam-Hansen
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Department of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Lu
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CZ
Fredrikson
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Baig
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D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D009103:Multiple Sclerosis / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D012192:Retroviridae Infections / Q000150:complications*
D012194:RNA-Directed DNA Polymerase