Second-look laparotomy in endodermal sinus tumor: a report of two patients with normal levels of alpha-fetoprotein and residual tumor at reexploration.
The role of second-look laparotomy in the management of patients with endodermal sinus tumor of the ovary is controversial. We report two women who converted to a normal alpha-fetoprotein (AFP) level during treatment with combination chemotherapy, yet were found to have residual endodermal sinus tumor at second-look laparotomy. In view of the limited experience with this rare disease, we continue to recommend second-look laparotomy for patients who have completed chemotherapy for endodermal sinus tumor of the ovary, regardless of the serum AFP level.
Curtin
J P
JP
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Rubin
S C
SC
Hoskins
W J
WJ
Hakes
T B
TB
Lewis
J L
JL
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007813:Laparotomy; D008649:Mesonephroma / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D012086:Reoperation; D000509:alpha-Fetoproteins / Q000097:blood*
D000509:alpha-Fetoproteins