[Significance of the lability of expression of lymphocyte E-receptors in the informative value of the theophylline test in normal subjects and in patients with viral hepatitis B].
The informative value of the theophylline test has been estimated in normal subjects and in hepatitis B patients during the acute period of the disease. Experiments with varying length of incubation at 37 degrees C have revealed a lability of expression of the lymphocytic E-receptors in hepatitis B patients: this expression has been the maximum after 15 min incubation with theophylline and the E-RFC count reduced after 30 and 60 min incubation, with the E-RFC most sensitive to theophylline detectable after 15 and 30 min incubation. Correlation between the results of theophylline test and T gamma-cell count have shown identical results in normal subjects in all incubation terms when the maximum expression of E-receptors has been observed in the tested samples. In hepatitis B patients no coincidence of the results has been observed: the count of theophylline-sensitive E-RFC on conversion to the total E-RFC count surpassed the count of T gamma-cells. These results lead to a conclusion that the theophylline test should not be used for estimation of regulatory T-lymphocytes in the patients with viral hepatitis B.
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D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007202:Indicators and Reagents; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D012397:Rosette Formation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013806:Theophylline
D000944:Antigens, Differentiation, B-Lymphocyte; D007202:Indicators and Reagents; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E; D013806:Theophylline
Znachenie labil'nosti ékspressii E-retseptorov limfotsitov dlia informativnosti teofillinovogo testa v norme i pri virusnom gepatite B.