Effect of hypo and hyperprolactinemia on the testicular maturation of Wistar rats during puberal transition.
In Wistar rats, the structural and metabolic organization of the testis was influenced by the blood concentration of prolactin. The androgen dependent enzyme activities in plasma as well as in testis were higher under hyperprolactinemia and lower under hypoprolactinemia, as induced by bromocriptine. While prolactin had direct effect on the testicular functions, bromocriptine seemed to exert its influence through blocking hypophysial prolactin.
Prasad
M
M
Department of Zoology, Sri Venkateswara University, Tirupati, India.
Uma Devi
G
G
Govindappa
S
S
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000502:physiology*; D013737:Testis / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism
D001971:Bromocriptine; D011388:Prolactin; D015096:3-Hydroxysteroid Dehydrogenases