Acute changes in 5-HT metabolism after S-adenosyl-L-methionine administration.
1. This study investigates S-adenosyl-L-methionine (SAM) (10 mg/kg, i.p.)acute effects upon 5-HT metabolism in rat brain areas. 2. One hour after SAM injection 5-HT biosynthesis was increased in the corpus striatum (55%), the hippocampus (3-fold) (82% 2 hr after SAM injection) and decreased in the olfactory bulbs (34%). 3. 5-HT levels were: (a) increased in the corpus striatum (39%), the hippocampus (44%) and the frontal cortex (27%), and oppositely reduced in the olfactory bulbs (47%) 1 hr after SAM injection; (b) increased in the hippocampus (39%) and reduced in the olfactory bulbs (35%) 1.5 hr after SAM injection; (c) increased in the hippocampus (25%) 2 hr after SAM injection. 4. 5-HIAA levels were reduced in the olfactory bulbs 27% or 21% after 1 hr or 1.5 hr from SAM injection respectively. 5. These area-related changes in 5-HT biosynthesis and metabolism might suggest a possible neurochemical substrate for the antidepressant properties of SAM.
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Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Cientificas y Técnicas, Piso, Buenos Aires, Argentina.
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D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D012701:Serotonin / Q000096:biosynthesis / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012436:S-Adenosylmethionine; D006916:5-Hydroxytryptophan