title: Voltage-gated currents recorded from the surface of the frog optic nerve.
abstract: Macroscopic voltage-dependent currents were recorded from the surface of the intact optic nerve of Rana pipiens using the loose patch clamp technique. Depolarizing steps of more than 40 mV produced sodium-dependent TTX sensitive inward currents and a 4-AP and sodium sensitive fast outward current in addition to a slower outward current. Since the surface of the nerve is a glia limitans, it appears that the membranes of these astrocytes contain both voltage-sensitive sodium and potassium channels.
authors: Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, Old San Juan.
authors: S
authors: S
authors: Ortiz
authors: O
authors: O
authors: Rodriguez
authors: P M
authors: PM
authors: Orkand
authors: R K
authors: RK
authors: Orkand
authors: H
authors: H
authors: Marrero
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D009469:Neuromuscular Junction / Q000502:physiology; D009900:Optic Nerve / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D011894:Rana pipiens; D015222:Sodium Channels / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels