[Is serotonin implicated in the pathogenesis of the alcohol abstinence syndrome?].
5-Hydroxyindoleacetic acid (5-HIAA), the main metabolite of 5-hydroxytryptamine or serotonin, excreted in the urine over a 24 hour period was systematically measured in 35 patients with alcohol withdrawal syndrome (AWS). The level of excreted urinary 5-HIAA ac. was high in only a few patients. The pathogenic mechanisms involved are discussed and though the role of serotonin in the pathogenesis of AWS seems of secondary importance, some 5-hydroxytryptamine methyl analogues may have a major role in the pathogenesis of hallucinations caused by alcohol withdrawal.
Nardoni
A
A
Divisione di Medicina Generale, Ospedale S. Antonio, Tolmezzo (Udine).
Di Piazza
V
V
Moretti
V
V
Copetti
R
R
Trinco
G
G
D000328:Adult; D000368:Aged; D000430:Alcohol Withdrawal Delirium / Q000209:etiology / Q000652:urine; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006212:Hallucinations / Q000209:etiology / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000652:urine*; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000652:urine
D012701:Serotonin; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid
E la serotonina implicata nella patogenesi della sindrome da astinenza alcoolica?