Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus.
Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus. They were moderately inhibitory to vaccinia virus but not inhibitory to adenovirus, coxsackievirus, poliovirus, parainfluenza virus, and reovirus. These results indicate that, with the exception of parainfluenza virus, enveloped viruses are specifically susceptible to the inhibitory activity of sulfated polysaccharides.
Baba
M
M
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Snoeck
R
R
Pauwels
R
R
de Clercq
E
E
D002351:Carrageenan / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D003911:Dextrans; D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester; D002351:Carrageenan; D006493:Heparin; D016264:Dextran Sulfate; C007789:fucoidan