Whole cell currents and mechanical responses of isolated outer hair cells.
Outer hair cells (OHCs) exhibit electrically induced cell movements which are considered to enhance the frequency selectivity and sensitivity of basilar membrane vibration. Using simultaneous whole cell voltage clamp and video analysis, we demonstrate that the mechanical response of OHCs is not altered by agents which alter membrane currents under voltage clamp. Thus the underlying mechanism of OHC movements appears to be dependent upon membrane potential, rather than transmembrane currents.
Santos-Sacchi
J
J
Laboratory of Otolaryngology, UMDNJ-New Jersey Medical School, Newark 07103.
Dilger
J P
JP
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects
D007473:Ion Channels