Reversible conductive hearing loss in mice.
Fibrin tissue adhesive was injected into the right ears of four 7-week-old CBA/J mice. Auditory brain stem responses (ABRs) were used to monitor changes in auditory sensitivity over the next 26 days, after which the middle ears and cochleas were examined histologically. Mean maximum ABR threshold shifts were as great as 36 dB, and were larger for higher frequencies than for lower. Maximum shifts occurred between 1 and 8 days; by 26 days, thresholds had returned to intensity levels observed before injection.
Hood
L J
LJ
Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology, Louisiana State University Medical Center, New Orleans 70112.
Webster
D B
DB
D000818:Animals; D007611:Aprotinin; D003051:Cochlea / Q000473:pathology; D004338:Drug Combinations; D004432:Ear, Middle / Q000473:pathology; D005072:Evoked Potentials, Auditory; D005176:Factor XIII; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D034381:Hearing Loss / Q000209:etiology*; D006314:Hearing Loss, Conductive / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013917:Thrombin; D013997:Time Factors; D014014:Tissue Adhesives
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin