[The structural organization of interferon molecules as precursors of immuno- and neuroactive oligopeptides].
The oligopeptides effecting signalling functions are postulated to emerge from protein precursors by limited proteolytic cleavage in close vicinity to appropriate cell receptors. A variety of immunological activities of interferons are probably mediated by this mechanism. The C-terminal tripeptides liberated from IFN-alpha in limited proteolysis reactions may result in a variety of polarins eliciting a wide spectrum of immunoregulatory effects, which in combination with the antiviral activity of IFN are responsible for effective defense mechanisms in the organism.
Chipens
G I
GI
Klusha
V E
VE
Ievinia
N G
NG
Tsilinskis
E E
EE
Skliarova
S N
SN
D000818:Animals; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007372:Interferons / Q000378:metabolism / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D009479:Neuropeptides / Q000096:biosynthesis / Q000494:pharmacology*; D009842:Oligopeptides / Q000096:biosynthesis / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D009479:Neuropeptides; D009842:Oligopeptides; D010446:Peptide Fragments; D011498:Protein Precursors; D007372:Interferons; D010447:Peptide Hydrolases
Strukturnaia organizatsiia molekul interferonov kak predshestvennikov immuno- i neĭroaktivnykh oligopeptidov.