Platelet alpha granule secretion in cerebral ischemia: effect of short and long term low dose aspirin treatment.
The effect of short and long-term therapy with aspirin (50 mg/day) on platelet alpha granule secretion was studied in 11 healthy controls and 57 patients suffering from transient cerebral ischemic attacks (TIA) with and without accompanying diabetes and hypertension. Plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF 4) were measured as indicators of platelet alpha granule secretion. beta-TG and PF 4 levels were increased following cerebral ischemia. Aspirin treatment failed to suppress plasma levels of both proteins when measured a month and then a year after initiation of treatment. Therefore, these proteins may be poor indicators of platelet inhibition by aspirin.
D'Andrea
G
G
Department of Neurology San Bortolo Hospital, Vicenza, Italy.
Joseph
R
R
Cananzi
A R
AR
Ferro-Milone
F
F
Grunfeld
S
S
Toldo
M
M
Welch
M A
MA
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin; D010978:Platelet Factor 4 / Q000097:blood; D010980:Platelet Membrane Glycoproteins / Q000097:blood*; D001620:beta-Thromboglobulin / Q000097:blood
D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D001241:Aspirin