HLA-C locus antigens seen by one-dimensional isoelectric focusing: definition of the so far known HLA-C specificities and of two subtypes.
A panel of homozygous typing cells was employed for biochemical definition of all known HLA-C locus antigens from Cw1 through Cw11. Each HLA-C antigen yielded, after precipitation with one of the monoclonal antibodies W6/32, 4E, or HC10, a specific banding pattern on one-dimensional isoelectric focusing gels. In addition, two biochemical subtypes of Cw1 and Cw7 could be identified. These biochemical HLA-C "splits" were characterized not only by different isoelectric points but also by strong linkage disequilibriums with certain HLA-B antigens.
Hajek-Rosenmayr
A
A
Institute for Blood Group Serology, Vienna, Austria.
Jungl
L
L
Stammler
M
M
Kirnbauer
M
M
D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007525:Isoelectric Focusing
D000911:Antibodies, Monoclonal; D000939:Epitopes; D015236:HLA-C Antigens