title: Lymphomatoid granulomatosis. A case for aggressive therapy.
abstract: Lymphomatoid granulomatosis is an uncommon disorder with features of vasculitis and lymphoma. Treatment has usually consisted of steroids and, occasionally, single cytotoxic drugs, but prognosis remains poor. The authors report a patient with life-threatening disease treated successfully with combination chemotherapy consisting of methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B) who achieved complete remission and remains disease-free over 3 years from diagnosis. Justification for an aggressive therapeutic approach to this disease is presented.
authors: Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200.
authors: T R
authors: TR
authors: Jenkins
authors: A J
authors: AJ
authors: Zaloznik
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy*; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate