Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XIX. Embryonic genes.
The methylation status of a conformation-inducer protein that would effect the status of DNA in relation to its ability to be in an active or inactive state is proposed to be central in the regulation of embryonic genes. Thus a distinction can be drawn between induceable "adult" genes such as glucocorticoid induced tyrosine aminotransferase and induceable "embryonic" genes such as ethionine induced alpha-fetoprotein. However, in the proposed mechanism the methylation of DNA is also important in that a hypomethylated state of a CCGG sequence of a promotor region for a conformation-induced protein gene is required to initiate the induction events.
Hancock
R L
RL
Efamol Research Institute, Kentville, Nova Scotia, Canada.
D000818:Animals; D002273:Carcinogens; D004247:DNA / Q000235:genetics*; D005796:Genes; D006801:Humans; D008745:Methylation; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics; D011401:Promoter Regions, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics*
D002273:Carcinogens; D000509:alpha-Fetoproteins; D004247:DNA