Alpha fetoprotein inhibits aggregation of human platelets.
The effect of human alpha-fetoprotein (AFP) on platelet aggregation induced by physiological (ADP, PAF, collagen, arachidonic acid) and aphysiological (ionophore A 23,187) activators was investigated. It was found that AFP at the concentrations of 60-750 micrograms/ml, i.e. far below that observed in human blood, inhibits platelet aggregation induced by physiological activators. Platelet aggregation induced by arachidonic acid was two-four times more sensitive to inhibition by AFP than that induced by other physiological agonists, whereas aggregation induced by A 23,187 was not affected by AFP even at concentration of 750 micrograms/ml.
Czokało
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Department of General and Experimental Pathology, Medical Academy, Białystok, Poland.
Tomasiak
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D000244:Adenosine Diphosphate / Q000378:metabolism; D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism; D000001:Calcimycin / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000494:pharmacology*
D001095:Arachidonic Acids; D010975:Platelet Aggregation Inhibitors; D000509:alpha-Fetoproteins; D000001:Calcimycin; D000244:Adenosine Diphosphate; D003094:Collagen