[Effect of daily immunization and antirabies gamma-globulin on the development of immune T-killers in inbred mice infected with the street rabies virus].
Daily administration of vaccine as well as combined use of antirabies gamma-globulin and vaccine were shown not to induce the production of immune T-killers possessing protective properties in adoptive transfer in mice pre-infected with street rabies virus in contrast to a single administration of a shock dose of antigen. Immune splenocytes protected 31-43% of mice infected with street rabies virus in a dose of 2-4 im LD50 and did not protect the animals infected with a dose of 12 im-LD50. After combined administration of immune splenocytes and an interferon inducer (double-stranded RNA) the additive protective effect was observed.
Gribencha
S V
SV
Reveneko
N G
NG
Barinskiĭ
I F
IF
D000818:Animals; D007114:Immunization / Q000379:methods*; D007116:Immunization, Passive; D007369:Interferon Inducers; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D011818:Rabies / Q000276:immunology* / Q000517:prevention & control; D011819:Rabies Vaccines / Q000008:administration & dosage*; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage*
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D011819:Rabies Vaccines; D005719:gamma-Globulins
Vliianie ezhednevnoĭ immunizatsii i antirabicheskogo gamma-globulina na formirovanie immunnykh T-killerov u lineĭnykh mysheĭ, zarazhennykh ulichnym virusom beshenstva.