title: The expression of CD 15 antigen on myeloid leukaemia cells--a new prognostic index for complete remission and for survival.
abstract: 377 untreated acute leukaemia patients were categorized according to FAB and cytochemical criterials and simultaneously phenotyped with the use of 6-21 monoclonal antibodies (MoAb) of VI series (W. Knapp, Vienna). The leukaemia phenotype was compared with the patients outcome after treatment. In adult ANLL patients a positive relationships was proved statistically between the expression of the CD 15 cell differentiation antigen on leukaemic blasts and the CR rate (p less than 0.01, chi 2 test). Also a comparison of the Kaplan-Meier survival curves revealed that the CD 15 positive group of ANLL patients has a better outcome than the CD 15 negative one (p less than 0.01, by Wilcoxon and Log-rank tests). Thus, examination of cell differentiation antigens could be a useful addition to existing risk assignment in acute leukaemia.
authors: International Society of Chemo-Immuntherapy Cooperative Group Vienna, Austria.
authors: J
authors: J
authors: Hołowiecki
authors: D
authors: D
authors: Lutz
authors: S
authors: S
authors: Krzemień
authors: V
authors: V
authors: Schranz
authors: K
authors: K
authors: Jagoda
authors: B
authors: B
authors: Hołowiecka
authors: F
authors: F
authors: Graf
authors: G
authors: G
authors: Kelenyi
authors: V
authors: V
authors: Callea
authors: M
authors: M
authors: Brugiatelli
mesh_terms: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000401:mortality; D016256:Lewis X Antigen; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; D016256:Lewis X Antigen