title: A case of mediastinal germ cell tumor radically operated on after neoadjuvant chemotherapy-combined resection of the superior vena cava and reconstruction with expanded-PTFE graft.
abstract: A case of primary mediastinal germ cell tumor, which was radically treated with reconstruction of the superior vena cava (SVC) after neoadjuvant chemotherapy, is reported herein. This tumor, accompanied with SVC syndrome, was initially unresectably advanced and chemotherapy, using cis-dichlorodiamine-platinum, vindesine and bleomycin, was administered, resulting in a partial response with a 65 per cent tumor regression. The serum human chorionic gonadotropin, which originally had a high value, became reduced in parallel with the tumor regression to within the normal range. Complete tumor resection with reconstruction of the SVC using an expanded polytetrafluoroethylene (EPTFE) graft was successfully performed. The patient has now returned to productive employment and the graft is patent without any clinical symptoms of recurrence, 15 months post-operatively. Neoadjuvant chemotherapy is considered to be vitally important for the treatment of germ cell tumors originating in the anterior mediastinum and an EPTFE graft with external ring support seems to be acceptable as an artificial substitute for SVC replacement.
authors: Department of Surgery, Chiba University School of Medicine, Japan.
authors: T
authors: T
authors: Fujisawa
authors: Y
authors: Y
authors: Yamaguchi
authors: N
authors: N
authors: Iwai
authors: Y
authors: Y
authors: Saitoh
authors: T
authors: T
authors: Ogawa
authors: H
authors: H
authors: Saitoh
authors: M
authors: M
authors: Shiba
authors: H
authors: H
authors: Yamakawa
authors: M
authors: M
authors: Baba
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D001807:Blood Vessel Prosthesis; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000601:surgery*; D011138:Polytetrafluoroethylene; D014683:Vena Cava, Superior / Q000601:surgery*; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D011138:Polytetrafluoroethylene; D002945:Cisplatin; D014751:Vindesine