[Bronchopulmonary local defense in nonspecific endobronchitis in patients with tuberculosis].
Local protection in patients with complicated tuberculosis was investigated. The bronchoalveolar lavage fluid (BALF) was tested for the levels of IgA, sIgA, IgM, IgG, lysozyme, activity of granulocyte proteinases (elastase and trypsin-like proteinases) and their acid-fast inhibitors, ability to produce interferons by the BALF cells, the BALF cell composition and functional activity of alveolar macrophages. The local protection was shown to be decreased in the patients with nonspecific inflammatory processes in the bronchi. The decrease was especially pronounced in the patients with purulent endobronchitis. The data indicated the necessity of using immunocorrectors in combined therapy of such patients.
Shesterina
M V
MV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001991:Bronchitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis* / Q000166:cytology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007372:Interferons / Q000096:biosynthesis; D009113:Muramidase / Q000032:analysis; D014397:Tuberculosis, Pulmonary / Q000150:complications*
D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D007372:Interferons; D009113:Muramidase
Bronkholegochnaia mestnaia zashchita pri nespetsificheskikh éndobronkhitakh u bol'nykh tuberkulezom.