title: Axonal transport of angiotensin-converting enzyme in the rat striatonigral pathway.
abstract: We analyzed the transport of angiotensin-converting enzyme (kininase II, EC 3.4.15.1) in the striatonigral pathway by quantitative autoradiography using the specific converting enzyme inhibitor, 125I-351A. 125I-351A binding was studied at different time intervals after knife cut lesions of the striatonigral pathway. Twenty-four h after the lesion, accumulations of 125I-351A binding sites were observed both rostral and caudal to the lesioned site. No change in 125I-351A binding was observed at this time in the caudate putamen and substantia nigra. Ten days after the lesion, a significant decrease (58%) in 125I-351A binding was found in the pars reticulata of the ipsilateral substantia nigra. These results suggest that the angiotensin-converting enzyme is transported axonally in the rat striatonigral pathway.
authors: Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
authors: M
authors: M
authors: Aiso
authors: W Z
authors: WZ
authors: Potter
authors: J M
authors: JM
authors: Saavedra
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D003342:Corpus Striatum / Q000502:physiology*; D004151:Dipeptides / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000502:physiology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D007457:Iodine Radioisotopes; C042037:L-proline, N2-((1S)-1-carboxy-3-phenylpropyl)-N6-((4-hydroxyphenyl)iminomethyl)-L-lysyl-; D007703:Peptidyl-Dipeptidase A