[The role of disorders of secretion of pancreatic enzymes and bile and bacterial contamination of the small intestine in the pathogenesis of diarrhea in patients with celiac disease].
The study of 53 patients with celiac disease provided evidence for the impotent role of the inhibited hyposecretion of pancreatic enzymes, atony of the gallbladder responsible for abnormal bile acids introduction into the intestinal lumen in digestion, elevated concentrations of free bile acids at the expense of lowjugated ones in duodenal and jejunal contents as well as bacterial dissemination of the proximal portion of the small intestine in pathogenesis of diarrhea observed in celiac disease. It is concluded that inclusion of continuous courses of enzyme preparations and light cholagogues in the treatment schemes of celiac disease and administration in its exacerbation of adsorbents, astringents, antibacterial preparations should be necessary therapeutic measures.
Loginov
A S
AS
Krums
L M
LM
Parfenov
A I
AI
Bychkov
Iu P
IuP
D000681:Amylases / Q000172:deficiency / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000172:deficiency / Q000378:metabolism*; D002446:Celiac Disease / Q000150:complications / Q000382:microbiology / Q000503:physiopathology*; D003967:Diarrhea / Q000209:etiology*; D004386:Duodenum / Q000382:microbiology*; D006801:Humans; D008049:Lipase / Q000172:deficiency / Q000378:metabolism*
D001647:Bile Acids and Salts; D008049:Lipase; D000681:Amylases
Ro'l narusheniia sekretsii pankreaticheskikh fermentov, zhelchi i bakteria'lnogo obsemeneniia tonkoĭ kishki v patogeneze diarei u bo'lnykh tseliakieĭ.