Nucleolar organiser regions in pituitary adenomas.
Nucleolar organiser regions have been identified by a silver-staining technique (AgNORs) and quantified in paraffin sections of normal foetal and adult pituitary gland and in a series of 35 pituitary adenomas, which included all the main types. In the adult pituitary there were 1.45 +/- 0.07 (mean +/- SEM) AgNORs per cell and in the foetal gland 2.94 +/- 0.37. The overall values for the adenomas were 1.98 +/- 0.08. Macroadenomas had significantly higher numbers (2.18 +/- 0.09) than microadenomas (1.69 +/- 0.11). Of the hormonally active tumours, corticotroph adenomas had the highest value (2.18 +/- 0.15), although four out of six were microadenomas.
McNicol
A M
AM
University Department of Pathology, Royal Infirmary, Glasgow, Great Britain.
Colgan
J
J
McMeekin
W
W
Teasdale
G M
GM
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D005333:Fetus; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D010902:Pituitary Gland / Q000033:anatomy & histology / Q000473:pathology; D010911:Pituitary Neoplasms / Q000473:pathology*; D013194:Staining and Labeling