title: Endothelium-dependent relaxations to histamine in the rat common carotid, renal and cranial mesenteric artery.
abstract: The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10(-8)-10(-4) M) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10(-8)-10(-7) M). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 X 10(-6) M), but not metiamide (10(-6) M), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 X 10(-6) M) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
authors: Department of Pharmacology, Faculty of Medicine, Belgrade, Yugoslavia.
authors: M K
authors: MK
authors: Krstić
authors: R M
authors: RM
authors: Stepanović
authors: S K
authors: SK
authors: Krstić
authors: Z S
authors: ZS
authors: Katusić
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D012077:Renal Artery / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D006632:Histamine; D011738:Pyrilamine; D000109:Acetylcholine