Ultrasonic tissue characterization of acute canine myocardial infarction.
This study assessed changes in left ventricular texture on two-dimensional (2-D) echocardiography after experimental myocardial infarction. In 13 dogs, the left anterior descending coronary artery (LAD) was occluded for 3 h, followed by 1 h of reperfusion and sacrifice. Two-dimensional echocardiography was performed pre-LAD occlusion, 3 h post occlusion and 1 h after reperfusion by placing a 5 MHz transducer on the chest wall. After sacrifice, triphenyltetrazolium chloride staining was performed on 1 cm thick left ventricular cross-sectional slices. Five dogs served as controls (shams). Two-dimensional echocardiograms were digitized and in the region of left ventricular asynergy (area of myocardial infarction), and adjacent normal area, the mean pixel intensities (+/- SD) were calculated. There was no significant change in the mean pixel intensity from 0 through 4 h in the lateral (22.8 +/- 1.3 and 23.4 +/- 1.8) and anteroseptal (23.2 +/- 1.9 and 22.6 +/- 1.9) regions in sham operated dogs. In dogs undergoing LAD occlusion, the mean pixel intensity from the pre- to post occlusion period showed no significant change in the lateral (normal) area, 24.4 +/- 2.7 versus 24.7 +/- 2.9. In the area of wall motion abnormality (area of myocardial infarction) the mean pixel intensity increased from 25.4 +/- 2.7 to 33.7 +/- 4.5, P less than 0.01. There was no significant change in the mean pixel intensity between the 3 h post occlusion and post reperfusion period in either the lateral (normal) or anteroseptal areas of the left ventricle. The area of left ventricular asynergy corresponded to the area of myocardial infarction on triphenyltetrazolium chloride stain.(ABSTRACT TRUNCATED AT 250 WORDS)
Tak
T
T
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Lin
S L
SL
Gamage
N
N
Mahler
C
C
Steen
S N
SN
Colletti
P
P
Rahimtoola
S H
SH
Chandraratna
P A
PA
D000208:Acute Disease; D000818:Animals; D003331:Coronary Vessels / Q000473:pathology; D004285:Dogs; D004452:Echocardiography; D006352:Heart Ventricles / Q000473:pathology; D007090:Image Interpretation, Computer-Assisted; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology; D013194:Staining and Labeling; D013778:Tetrazolium Salts
D013778:Tetrazolium Salts; C009591:triphenyltetrazolium