Lack of physiological stimulation induces decreased proteolytic activity in nerve terminals.
The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decreased degradation of slowly transported labeled proteins in the nerve terminals in the superior colliculus.
Gustavsson
S
S
Institute of Neurobiology, University of Göteborg, Sweden.
Karlsson
J O
JO
D000818:Animals; D001370:Axonal Transport; D005260:Female; D008297:Male; D009411:Nerve Endings / Q000201:enzymology* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000502:physiology; D013477:Superior Colliculi / Q000378:metabolism
D009419:Nerve Tissue Proteins; D010447:Peptide Hydrolases