title: Synthesis and channel properties of [Tau 16]gramicidin A.
abstract: Des(ethanolamine)-taurine16-gramicidin A ([Tau 16]gramicidin A) was synthesized by the solid phase method and its channel-forming behavior in planar lipid bilayers was examined. The purified monovalent anionic peptide formed channels when applied to the aqueous compartments on both sides of the bilayer, but not when applied to one side only. The single-channel conductance was measured for KCl concentrations between 0.1 and 1.0 M and was found to be higher than that of gramicidin A in each case. Single-channel lifetimes were similar to those of gramicidin A suggesting that the channels have the beta 6.3 helix structure.
authors: Department of Biochemistry, Indiana University School of Medicine, Indianapolis.
authors: R W
authors: RW
authors: Roeske
authors: T P
authors: TP
authors: Hrinyo-Pavlina
authors: R S
authors: RS
authors: Pottorf
authors: T
authors: T
authors: Bridal
authors: X Z
authors: XZ
authors: Jin
authors: D
authors: D
authors: Busath
mesh_terms: D006096:Gramicidin / Q000138:chemical synthesis / Q000378:metabolism* / Q000031:analogs & derivatives; D007473:Ion Channels / Q000378:metabolism*; D008968:Molecular Conformation; D011189:Potassium Chloride / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D007473:Ion Channels; C060490:des(ethanolamine)taurine(16)-gramicidin A; D006096:Gramicidin; D013654:Taurine; D011189:Potassium Chloride