title: [Changes in the parameters of nonspecific protection of mice upon inoculation of double-stranded RNA from Saccharomyces cerevisiae yeasts].
abstract: The results of the study of the effect of double-stranded (ds) RNA from killer yeasts Sac. cerevisiae on the parameters of nonspecific protection are presented. Inoculation of dsRNA in a dose of 5 mg/kg intramuscularly was shown to induce interferon production, to increase body temperature, the activity of adrenal cortex, phagocytic activity of macrophages of the peritoneal exudate and blood neutrophils, the level of lysozyme in the blood, and the activity of macrophage acid phosphatase. The increase in the functional activity of the system components was observed at similar intervals, within 3-6 hours after administration of the preparation. The mutual induction of factors of nonspecific protection and their cooperative participation in the formation of antiviral resistance under the effect of dsRNA is discussed.
authors: K N
authors: KN
authors: Verevkina
authors: E D
authors: ED
authors: Danilenko
authors: A N
authors: AN
authors: Kostomakha
authors: Iu N
authors: IuN
authors: Zarvina
authors: V S
authors: VS
authors: Sazonov
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000311:Adrenal Glands / Q000276:immunology; D000818:Animals; D007113:Immunity, Innate; D007372:Interferons / Q000096:biosynthesis* / Q000276:immunology; D008264:Macrophages / Q000201:enzymology; D051379:Mice; D008808:Mice, Inbred CBA; D009113:Muramidase / Q000097:blood; D010587:Phagocytosis; D012330:RNA, Double-Stranded / Q000276:immunology*; D012441:Saccharomyces cerevisiae
chemical_list: D012330:RNA, Double-Stranded; D007372:Interferons; D000135:Acid Phosphatase; D009113:Muramidase
vernacular_title: Izmenie pokazateleĭ nespetsificheskoĭ zashchity organizma mysheĭ pri vvedenii dvuspiral'noĭ RNK iz drozhzheĭ Saccharomyces cerevisiae.