title: Selective expression of cytokeratin polypeptides in various epithelia of human Brenner tumor.
abstract: A human ovarian Brenner tumor presenting a wide spectrum of benign and malignant histologic features was studied for its patterns of intermediate filament expression. All epithelial elements of the tumor, regardless of their morphologic type, contained cytokeratins as their only intermediate filament component. Differences were detected, however, between tumor nests that displayed transitional epithelium and those with squamoid features. These differences were manifested by the presence of cytokeratin 18, in the former type only, and by the abundance of cytokeratins 10/11 in the latter. We also detected mixed epithelial nests in which both features were present, suggesting that the transitional epithelium transforms in polar fashion into squamous epithelium. Examination of cytokeratin patterns found in urothelium and in the surface epithelium of the ovary pointed to certain differences from the Brenner tumor epithelia. The significance of these latter findings with regard to cellular transformation and histogenesis of the Brenner tumor are discussed.
authors: Department of Pathology, Kaplan Hospital, Rehovot, Israel.
authors: B
authors: B
authors: Lifschitz-Mercer
authors: B
authors: B
authors: Czernobilsky
authors: E
authors: E
authors: Shezen
authors: R
authors: R
authors: Dgani
authors: O
authors: O
authors: Leitner
authors: B
authors: B
authors: Geiger
mesh_terms: D000911:Antibodies, Monoclonal; D001948:Brenner Tumor / Q000032:analysis* / Q000473:pathology; D003598:Cytoskeletal Proteins; D003893:Desmin / Q000032:analysis; D051180:Desmoplakins; D003896:Desmosomes; D004848:Epithelium / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000032:analysis* / Q000473:pathology; D010053:Ovary / Q000032:analysis / Q000166:cytology; D001749:Urinary Bladder Neoplasms / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D003598:Cytoskeletal Proteins; D003893:Desmin; D051180:Desmoplakins; D008562:Membrane Glycoproteins; D014746:Vimentin; D007633:Keratins