title: Permeability to various cations of the voltage-dependent sodium channel of isolated rat hippocampal pyramidal neurons.
abstract: The permeability to various cations of the voltage-dependent sodium channel of isolated rat hippocampal pyramidal neurons was investigated under the voltage-clamp condition. The neurons were dispersed enzymatically and mechanically and perfused internally using a suction pipette technique. The permeability sequence, estimated from the reveral potential of the inward current was Li+ greater than Na+ greater than hydrazine+ greater than formamidine+ greater than guanidine+ greater than methylguanidine+ greater than monomethylamine+. Thus the ionic selectivity of the voltage-dependent sodium channel of rat central nervous system neurons is similar to that in the squid axon, myelinated frog nerve fiber and rat ventricle muscle.
authors: Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors: M
authors: M
authors: Kaneda
authors: Y
authors: Y
authors: Oomura
authors: O
authors: O
authors: Ishibashi
authors: N
authors: N
authors: Akaike
mesh_terms: D000818:Animals; D002412:Cations / Q000378:metabolism / Q000502:physiology; D002463:Cell Membrane Permeability; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D051381:Rats; D012964:Sodium / Q000378:metabolism / Q000502:physiology*
chemical_list: D002412:Cations; D007473:Ion Channels; D012964:Sodium