Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents.
The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4 degrees C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing greater than 0.1 M chloride.
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Bath Cancer Research Unit, Royal United Hospital, Combe Park, England.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000677:Amsacrine / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004355:Drug Stability; D004356:Drug Storage; D007372:Interferons / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000494:pharmacology; D010984:Platinum / Q000494:pharmacology; D012996:Solutions; D014748:Vinca Alkaloids / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D012996:Solutions; D014748:Vinca Alkaloids; D000677:Amsacrine; D010984:Platinum; D007372:Interferons; D001215:Asparaginase; D002945:Cisplatin