Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion.
Intraventricular infusion of the stable substance P analogue, DiMethyl-C7, was found to produce aversion in a place conditioning paradigm. This effect was independent of state dependent learning since the place aversion was also seen when the subjects were tested under the influence of the drug. A role for substance P in aversion is discussed.
Elliott
P J
PJ
Department of Experimental Psychology, Cambridge University, U.K.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology
D010446:Peptide Fragments; D013373:Substance P; C032720:substance P (5-11), pGlu(5)-MePhe(8)-MeGly(9)-; D011761:Pyrrolidonecarboxylic Acid