Anti-inflammatory effects of endothelin-1.
Endothelin-1 (ET-1), when injected intradermally in rats concurrently with FMLP, did not suppress cell accumulation 6 h later. In view of the fact that ET-1 can antagonize mediators of increased vascular permeability, it is proposed that this is further evidence that fluid and cell accumulation at an inflammatory site are separate processes.
Chander
C L
CL
Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, England.
Moore
A R
AR
Desa
F M
FM
Howat
D W
DW
Willoughby
D A
DA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002199:Capillary Permeability / Q000187:drug effects; D016232:Endothelins; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016232:Endothelins; D010455:Peptides; D009240:N-Formylmethionine Leucyl-Phenylalanine