[A system of assessing interleukin-2-dependent activation of B-lymphocytes].
The peripheral blood B-lymphocyte responsiveness to interleukin-2 (IL-2) has been studied in healthy donors. Unstimulated B-cells proliferated moderately in response to IL-2, this being not associated with an increase of TAC-positive cells. Phytolacca mitogen did not stimulate purified B-cells to proliferation and did not influence TAC expression and responsiveness to IL-2. S. aureus mitogen (SAC) provided a maximum proliferation in response to IL-2 with a dramatic increase of TAC expression. Simultaneous estimation of unstimulated and SAC-preactivated B-lymphocyte responses to IL-2, together with scintillation of TAC-positive cells, helps determine the degree of a possible injury to IL-2 receptor.
Lozovoĭ
V P
VP
Kiselev
S V
SV
Kotenev
V M
VM
D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000502:physiology
D007376:Interleukin-2; D008934:Mitogens; D015375:Receptors, Interleukin-2
Sistema otsenki interleĭkin-2-zavisimoĭ aktivatsii B-limfotsitov.