Effect of low doses of gamma-hydroxybutyric acid on serotonin, noradrenaline, and dopamine concentrations in rat brain areas.
The effects of intraperitoneal administration of gamma-hydroxybutyric acid (GHB) on biogenic amine levels in hemispheres, hypothalamus, midbrain, and medulla-pons, and on tryptophan in serum and brain, were studied. One hour after GHB administration (50 and 100 mg/kg) significant increases of dopamine concentration were observed in the hemispheres with both doses and in the hypothalamus with the higher dose, but a significant decrease of noradrenaline in the hypothalamus. No significant changes of serotonin metabolism were observed. These results indicate that low doses of GHB selectively affect the catecholaminergic neuronal activity.
Míguez
I
I
Department of Physiology, Faculty of Pharmacy, University of Santiago de Compostela, Spain.
Aldegunde
M
M
Duran
R
R
Veira
J A
JA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006885:Hydroxybutyrates / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012978:Sodium Oxybate / Q000494:pharmacology*; D014364:Tryptophan / Q000378:metabolism
D006885:Hydroxybutyrates; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012978:Sodium Oxybate; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine