Immunocytochemistry of anaplastic carcinoma of thyroid gland.
Twelve anaplastic thyroid carcinomas were investigated with a panel of antibodies. The squamoid and giant cell anaplastic carcinomas showed coexpression of cytokeratin and vimentin in 66% of the cases. Reactivity for A-1-AT and A-1-ACT antiserum appeared when the spindle cell component became prevalent. The antidesmoplakin antibody can be employed on cryostat sections in differential diagnosis between sarcoma and carcinoma of the thyroid.
Beltrami
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Istituto di Anatomia Patologica, Cattedra di Istituzioni di Anatomia Patologica, Università degli Studi di Ancona, Italia.
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Di Loreto
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D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000032:analysis* / Q000175:diagnosis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000175:diagnosis; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000032:analysis* / Q000175:diagnosis / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D008562:Membrane Glycoproteins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D007633:Keratins