The role of alpha-2u-globulin in corticosteroidogenesis in male rats.
Administration of estradiol-17 beta for 7 days to the adult male rat results in adrenal hyperplasia, decreased serum corticosterone along with elevation in serum ACTH and inhibition of adrenal 5-ene-3 beta-hydroxysteroid dehydrogenase activity (5-ene-3 beta-HSD). Treatment with alpha 2u-globulin for following 14 days of estrogen-treated rats reversed the effects of estrogen while in normal rats alpha 2u-globulin treatment increased adrenal 5-ene-3 beta-HSD activity and serum corticosterone level while causing a fall in serum ACTH. It is concluded that alpha 2u-globulin may play a role in ACTH secretion by inducing corticosterone synthesis.
Ghosh
P K
PK
Department of Physiology, University Colleges of Science and Technology, Calcutta, India.
Biswas
N M
NM
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis* / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000510:Alpha-Globulins / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000305:Adrenal Cortex Hormones; D000510:Alpha-Globulins; C013803:alpha 2u globulin; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D015096:3-Hydroxysteroid Dehydrogenases; D003345:Corticosterone