[Clinical significance of fibronectin and protease inhibitors in chronic obstructive pulmonary diseases].
Plasma fibronectin (Fn) and protease inhibitors (alpha 2-macroglobulin, alpha 2-MG, antithrombin, AT-III activity and content) were measured in 74 COPD patients and 53 normal controls. It was showed: (1) Fn, alpha 2-MG. AT-III activity were considerably decreased in COPD, when compare with that of controls; (2) there is a negative correlation between the value of PaCO2, r = -0.719, P less than 0.01. It indicated that the Fn, AT-III activity and alpha 2-MG are closely correlated with the extent and degree of respiratory decompensation. Dynamic changes of these parameters are of some prognostic significance in COPD.
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D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D011480:Protease Inhibitors / Q000097:blood*; D000511:alpha-Macroglobulins / Q000032:analysis
D005353:Fibronectins; D011480:Protease Inhibitors; D000511:alpha-Macroglobulins; D000990:Antithrombin III