[Clinical significance of pregnancy-specific beta glycoprotein, human placental lactogen and beta-human chorionic gonadotropin in the serum of patients with trophoblastic diseases].
Serum levels of pregnancy specific beta 1 glycoprotein (SP1), human placental lactogen (hPL) and beta-human chorionic gonadotropin (beta-hCG) in the normal men, non-pregnant women, normal pregnant women and patients with trophoblastic diseases were determined by radioimmunoassay. Serum SP1, hPL and beta-hCG levels in patients with trophoblastic diseases decreased with advance of the degree of malignancy. The SP1/beta-hCG ratio was less than 1.5 in 4/36(11.1%) of the cases of hydatidiform mole, 13/16 (81.2%) of the cases of invasive mole and choriocarcinoma. The beta-hCG/hPL ratios were below 15 in 30/36 (83.3%) of the cases of hydatidiform mole and 4/16(25.5%) of the cases of malignant trophoblastic disease. After operation and chemotherapy, patients with SP1 and beta-hCG levels decreased gradually achieved favourable prognosis. Thus, this may be used as an index for monitoring and follow-up studies of trophoblastic disease.
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D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D014328:Trophoblastic Neoplasms / Q000097:blood*; D014594:Uterine Neoplasms / Q000097:blood*
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen