[Interferon-specific cellular receptors in cultured human cells, differing in sensitivity to alpha-interferon].
The interferon-specific cellular receptors in human cells cultures differing in sensitivity to alpha-interferon have been studied. The J-41 cells resistant to alpha-interferon are practically devoid of receptors highly specific to alpha-interferon. The coefficient of equilibrium and the number of receptors analyzed after Scatchard for J-96 culture of cells are 15.6 x 10(11) M-1 and 210 +/- 90, respectively. Evidently, resistance of J-41 cells to alpha-interferon is connected with the absence of interferon receptors and, as a consequence, inability to interferon-receptor interaction.
Narovlianskiĭ
A N
AN
Amchenkova
A M
AM
Borukhov
S I
SI
Alimov
E G
EG
Strongin
A Ia
AIa
Khesin
Ia E
IaE
D002478:Cells, Cultured; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007372:Interferons / Q000378:metabolism; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D011994:Recombinant Proteins
D007370:Interferon Type I; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D007372:Interferons
Interferon-spetsificheskie kletochnye retseptory v kul'turakh chelovecheskikh kletok, razlichaiushchikhsiia po chuvstvitel'nosti k alpha-interferonu.