[The effects of immuno-chemotherapy, hyperthermia and irradiation on the growth of human renal cell carcinoma].
In order to investigate more effective treatments for advanced renal cell carcinoma, experiments were performed as to inhibitory effects on the growth of KPK 1 cells derived from a human renal carcinoma. IFN-beta, IFN-gamma, vinca alkaloids (VBL, VCR, VDS), hyperthermia and irradiation inhibited the growth of KPK 1 cells. Both IFN-beta and IFN-gamma showed concentration dependent and time dependent inhibitory effects, and IFN-beta was significantly more intensive in action than IFN-gamma. All of vinca alkaloids inhibited the cell growth remarkably but there was no difference among these three drugs. Hyperthermia was inhibitory over 43 degrees C and irradiation showed a remarkable inhibition at not less than 500 rads. But IFN-alpha and hormones had no inhibitory effect. These results imply that multidisciplinary treatments in combination of immuno-chemotherapy with IFN-beta, IFN-gamma or vinca alkaloids, hyperthermia and irradiation should be applied for advanced renal cell carcinoma.
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D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006979:Hyperthermia, Induced; D007372:Interferons / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014748:Vinca Alkaloids; D007372:Interferons