title: Effects of tachykinins on mucus secretion in human bronchi in vitro.
abstract: We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.
authors: Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
authors: D F
authors: DF
authors: Rogers
authors: B
authors: B
authors: Aursudkij
authors: P J
authors: PJ
authors: Barnes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism; D015288:Neurokinin A / Q000494:pharmacology; D015287:Neurokinin B / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology*; D015320:Tachykinins / Q000494:pharmacology*
chemical_list: D006020:Glycopeptides; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B; D015260:Neprilysin; C008890:phosphoramidon