Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.
The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.
Iida
T
T
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
Kobayashi
E
E
Yoshida
M
M
Sano
H
H
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000494:pharmacology; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D006859:Hydrogen; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes; D011083:Polycyclic Compounds / Q000032:analysis* / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D000903:Antibiotics, Antineoplastic; D002247:Carbon Isotopes; D009281:Naphthalenes; D011083:Polycyclic Compounds; C061465:calphostin complex; C058747:calphostin A; C061462:calphostin B; C061464:calphostin I; D006859:Hydrogen; D011493:Protein Kinase C; C061463:calphostin D; C058819:calphostin C