Effects of cimaterol, a beta-adrenergic agonist, on protein metabolism in rats.
Fractional accretion rates of total body 3-methylhistidine containing proteins (actin and myosin) were elevated 40% to 120% in rats fed a high-carbohydrate diet containing 10 or 100 ppm cimaterol for 1 week. Fractional degradation and fractional synthesis rates of these proteins were examined by measuring total body 3-methylhistidine content and urinary excretion of 3-methylhistidine. Consumption of the diet containing 100 ppm cimaterol for 1 week caused a 25% reduction in fractional degradation rates and a concomitant 32% increase in fractional synthesis rates of 3-methylhistidine containing proteins. Effects of cimaterol on fractional accretion, degradation, and synthesis rates of 3-methylhistidine containing proteins diminished after 1 week. Cimaterol failed to influence plasma insulin, triiodothyronine, or corticosterone concentrations. The dramatic increase in accretion of 3-methylhistidine containing proteins observed during the first week rats are fed diets containing cimaterol is caused by reciprocal action on protein degradation and synthesis.
Eadara
J K
JK
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
Dalrymple
R H
RH
DeLay
R L
RL
Ricks
C A
CA
Romsos
D R
DR
D000199:Actins / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001835:Body Weight; D004247:DNA / Q000032:analysis; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D002149:Energy Intake; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006728:Hormones / Q000097:blood; D008762:Methylhistidines / Q000032:analysis / Q000652:urine; D009218:Myosins / Q000378:metabolism*; D009929:Organ Size; D012313:RNA / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D000199:Actins; D000318:Adrenergic beta-Agonists; D000596:Amino Acids; D004040:Dietary Carbohydrates; D004983:Ethanolamines; D006728:Hormones; D008762:Methylhistidines; D012313:RNA; D004247:DNA; D009218:Myosins; C028118:3-methylhistidine; C047411:cimaterol