The role of interferon in the protection of ICR Swiss male mice by the nondiabetogenic variant of encephalomyocarditis virus against virus-induced diabetes mellitus.
The production of murine diabetes mellitus by the diabetogenic variant of encephalomyocarditis virus (EMCV-D) is prevented in mice preinfected for 24 h with nondiabetogenic virus (EMCV-B). It has been suggested that the protection of the animals is due to the induction of interferon (IFN) by EMCV-B. The present study was done to investigate further the role of IFN in the protection of male ICR Swiss mice against the diabetogenic effects of EMCV-D virus. The results show that this mouse strain is protected only by viable EMCV-B given by either the i.v. or i.p. route of inoculation and that the protection is not abrogated by anti-IFN gamma-globulin. Further, the animals were not protected by either IFN-alpha, IFN- beta, or IFN- alpha/beta at concentrations shown previously to protect mice against the lethal effects of other variants of EMCV. The data provide further evidence that, in the ICR Swiss mouse, IFN does not play a major role in protecting pancreatic beta-cells against infection by EMCV-D.
Kaptur
P E
PE
Department of Microbiology and Immunology, College of Science and Mathematics, Wright State University, Dayton, OH 45435.
Thomas
D C
DC
Giron
D J
DJ
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000517:prevention & control*; D004686:Encephalomyocarditis virus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D014644:Genetic Variation; D007372:Interferons / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014762:Viral Interference / Q000502:physiology; D014779:Virus Replication
D000906:Antibodies; D007372:Interferons