Sickle cell-hereditary persistence of fetal haemoglobin and its differentiation from other sickle cell syndromes.
Some haematological indices were compared in 13 subjects with sickle cell-hereditary persistence of fetal haemoglobin (S-HPFH) and in 10 patients with homozygous sickle cell (SS) disease and four patients with sickle cell-beta zero thalassaemia, all with fetal haemoglobin (HbF) levels of 20% or above. Sickle cell-beta zero thalassaemia could be differentiated by a high HbA2 level. S-HPFH could be distinguished from SS disease with a high HbF level by red cell count, HbF level, reticulocyte count, total haemoglobin and total bilirubin level in decreasing power of discrimination.
Murray
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N
Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston.
Serjeant
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BE
Serjeant
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GR
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000235:genetics; D002648:Child; D004906:Erythrocyte Count; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005838:Genotype; D006443:Hemoglobin A2 / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D006443:Hemoglobin A2; D005319:Fetal Hemoglobin