A comment on H-2-restricted T cell recognition of Mls determinants: a question of perspective.
Data presented here addressed the question of whether T lymphocyte recognition of Mls determinants is MHC restricted. Using isolated T cell blasts from primary MLCs involving H-2-identical, Mls-disparate strain combinations as responding cell populations in secondary MLCs, and measuring their responses against fresh stimulating cells from different strains, has permitted the study of reactions towards Mls determinants in the presence of MHC antigenic differences. Results strongly suggest that recognition of Mlsc (Mls-2 locus) determinants is H-2 restricted. In contrast, there is still little evidence that the recognition of Mlsa (Mls-1 locus) determinants is H-2 restricted. Furthermore, data are also presented which refute the notion that different H-2 haplotypes possess different abilities to present Mlsa determinants to responding T cells.
Peck
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Department of Pathology, College of Medicine, University of Florida, Gainesville 32610.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005260:Female; D005720:Gamma Rays; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D066298:In Vitro Techniques; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
D000954:Antigens, Surface; D000939:Epitopes; D006183:H-2 Antigens; D016747:Minor Lymphocyte Stimulatory Antigens; D008937:Mitomycins; D016685:Mitomycin