title: Can immunohistology improve detection of lymph-node metastases in large-bowel cancer?
abstract: Employing the monoclonal antibody CAM5.2, the sensitivity of immunohistologic staining was compared with conventional hematoxylin and eosin staining for detection of lymph-node metastases from large-bowel cancer. Ten patients who died unexpectedly early from recurrent disease were selected; 86 lymph nodes were examined. Where metastases were located they were readily identified by both methods but when the original lymph-node sections were reviewed, attention was drawn to two metastatic deposits that had been overlooked previously. These results suggest that immunohistologic techniques offer no advantage in the identification of lymph-node metastases in large-bowel cancer.
authors: Imperial Cancer Research Fund, Lincolns Inn Fields, London, United Kingdom.
authors: C A
authors: CA
authors: Makin
authors: L G
authors: LG
authors: Bobrow
authors: R J
authors: RJ
authors: Nicholls
mesh_terms: D000911:Antibodies, Monoclonal; D003110:Colonic Neoplasms; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000473:pathology; D013194:Staining and Labeling
chemical_list: D000911:Antibodies, Monoclonal