Thai (delta beta)0-thalassemia and its interaction with gamma-thalassemia.
A variant of Southern Italian (delta beta)0-thalassemia is described in a women of Thai origin. The 3' breakpoint in Thai (delta beta)0-thalassemia is located about 1 kb upstream to that in Southern Italian (delta beta)0-thalassemia and produces a smaller deletion of approximately equal to 12.5 kb. Hematological phenotype, particularly Hb F output, is similar to that found in G gamma A gamma(delta beta)0-thalassemia despite the presence of a coexistent gamma-thalassemia effect.
Trent
R J
RJ
Molecular Biology Laboratory, University of Sydney, NSW, Australia.
Svirklys
L
L
Jones
P
P
D002872:Chromosome Deletion; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005914:Globins / Q000235:genetics*; D006801:Humans; D007558:Italy; D012150:Polymorphism, Restriction Fragment Length; D013785:Thailand; D013789:Thalassemia / Q000097:blood / Q000145:classification / Q000235:genetics*
D005914:Globins; D005319:Fetal Hemoglobin