Do ribosomes regulate mitochondrial RNA synthesis?
The levels of different classes of mitochondrially encoded transcripts are developmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. I propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or post-transcriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other systems.
Jacobs
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D000818:Animals; D005786:Gene Expression Regulation; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D000077278:RNA, Mitochondrial; D012270:Ribosomes / Q000378:metabolism / Q000502:physiology*; D012617:Sea Urchins / Q000378:metabolism
D000077278:RNA, Mitochondrial; D012313:RNA