Response of the benign hypertrophied prostate to treatment with an LHRH analogue.
Twenty patients with outflow tract obstruction secondary to benign prostatic hypertrophy were treated with an LHRH analogue, buserelin, for up to 6 months. Despite maintaining castrate levels of testosterone and achieving a significant reduction in tissue levels of dihydrotestosterone, no significant improvement was seen in flow rate or residual volume.
Keane
P F
PF
Department of Urology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Timoney
A G
AG
Kiely
E
E
Williams
G
G
Stamp
G
G
D002064:Buserelin / Q000627:therapeutic use*; D002369:Castration; D012739:Gonadal Steroid Hormones / Q000032:analysis; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology; D014554:Urination / Q000187:drug effects
D012739:Gonadal Steroid Hormones; D002064:Buserelin