[An immunohistological study of metastatic adenocarcinoma of the lymph node: is it useful in diagnosing a primary tumor?].
An immuno-histological study of metastatic adenocarcinoma has revealed the following results. Metastatic adenocarcinomas of the lymph-node of pulmonary and colonic origin were positive for CEA and negative for lysozymes, and those from gastric, pancreatic, and gallbladder tumors were positive CEA and lysozymes, and those from gastric and pancreatic tumors were positive for the secretory component. The prostate specific antigen was exclusively positive for metastatic prostatic adenocarcinoma with a low frequency and prostate acid phosphatase had many false positive results. Thyroglobulin was found to be positive only to colloid. Lactalbumin showed no specificity to metastatic breast adenocarcinoma. For achieving the final diagnosis of a primary tumor, its location in lymph nodes, the clinical history and the results of other examinations must also be taken into consideration.
Hamaya
K
K
Anatomic Pathology, Okayama Saiseikai General Hospital.
Doi
K
K
Yoshizawa
S
S
Motoi
M
M
D000230:Adenocarcinoma / Q000556:secondary*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000175:diagnosis; D006801:Humans; D007633:Keratins / Q000032:analysis; D007768:Lactalbumin / Q000032:analysis; D008175:Lung Neoplasms / Q000175:diagnosis; D008207:Lymphatic Metastasis / Q000473:pathology*; D009113:Muramidase / Q000032:analysis; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D012635:Secretory Component / Q000032:analysis
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D012635:Secretory Component; D007633:Keratins; D007768:Lactalbumin; D009113:Muramidase