Design of a new hydrocolloid dressing.
Hydrocolloid dressings composed of dextran, phospholipid, glycerol and sodium lauryl sulphate have been formulated. A ventilated hygrometer system has been used to study the evaporative water loss (EWL) from the excised wound of rats with and without these dressings. A statistical experimental design has been used to locate a formulation which is flexible and semiocclusive in nature. The phospholipid component of the dressing has a significant role in controlling water vapour permeability of the dressing. The EWL from the excised wound covered with the optimized dressing has been compared with that for two commercial products.
Nangia
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Department of Pharmacy, University of Otago Medical School, Dunedin, New Zealand.
Hung
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D000818:Animals; D047070:Bandages, Hydrocolloid; D002056:Burns / Q000628:therapy; D003102:Colloids / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use; D009779:Occlusive Dressings; D051381:Rats; D011919:Rats, Inbred Strains; D014870:Water Loss, Insensible; D014945:Wound Healing
D003102:Colloids; D003911:Dextrans