Optic neuritis and multiple sclerosis. Cell-mediated cytotoxicity by peripheral blood lymphocytes against basic protein of myelin, encephalitogenic peptide, cerebrosides and gangliosides.
On examination in the first weeks after onset of the disease, cell-mediated cytotoxicity against encephalitogenic peptide, myelin basic protein (MBP), cerebrosides and gangliosides was demonstrable in 32 (76%) of 42 patients with optic neuritis (ON). 14 patients with ON and concomitant neurological symptoms (ON/MS) had positive findings with all antigens, especially with the encephalitogenic peptide. The cytotoxic reactions against all antigens showed a close correlation with the course of ON: when the disease improved, the cytotoxicity decreased and became negative on average 4 months after ON onset. As previously reported, cell-mediated cytotoxicity against the above-mentioned antigens, especially the encephalitogenic peptide, may be considered as a pathogenetic factor in multiple sclerosis (MS). A positive reaction with this antigen in patients with ON only probably indicates the first manifestations of MS.
Frick
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Neurological Clinic, Munich University Hospital Grosshadern, FRG.
D000293:Adolescent; D000328:Adult; D002554:Cerebrosides / Q000276:immunology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D005260:Female; D005732:Gangliosides / Q000276:immunology; D006657:Histones / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D009902:Optic Neuritis / Q000276:immunology*
D002554:Cerebrosides; D002556:Cerebrospinal Fluid Proteins; D005732:Gangliosides; D006657:Histones; D007074:Immunoglobulin G; D004676:Myelin Basic Protein