title: Transient postnatal elevation of serotonin levels in mouse neocortex.
abstract: Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors: C F
authors: CF
authors: Hohmann
authors: R
authors: R
authors: Hamon
authors: M L
authors: ML
authors: Batshaw
authors: J T
authors: JT
authors: Coyle
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine