K+ channels activated by L-alanine transport in isolated Necturus enterocytes.
Using the patch-clamp technique, we demonstrate here the opening of K+ channels evoked by the actively transported amino acid L-alanine in isolated Necturus enterocytes. These channels had a conductance of about 30 pS and their activation was dependent on transmembrane electrical potential and cytosolic Ca2+.
Sheppard
D N
DN
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, England.
Giraldez
F
F
Sepúlveda
F V
FV
D000409:Alanine / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active; D002122:Calcium Chloride / Q000494:pharmacology; D002478:Cells, Cultured; D004553:Electric Conductivity; D007422:Intestines / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009337:Necturus; D011188:Potassium / Q000378:metabolism*
D007473:Ion Channels; D002122:Calcium Chloride; D000409:Alanine; D011188:Potassium