The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain.
Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologically demonstrable zinc as assessed by means of a modified Timm's sulphide-silver method. It is suggested that the selective injury of hippocampal neurons induced by kainic acid is not contingent on the release of zinc from mossy-fiber terminals.
Théorêt
Y
Y
Department of Pathology, University of North Carolina, Chapel Hill 27514.
Earnhardt
T S
TS
Bouldin
T W
TW
Krigman
M R
MR
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D011712:Pyramidal Tracts / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013194:Staining and Labeling
D007608:Kainic Acid