Pattern of oral cytokeratins. II. SDS-electrophoretic analysis of cytokeratins in reactive hyperkeratoses and Lichen ruber planus of the oral mucosa.
In SDS-electrophoresis the hyperortho- and hyperparakeratoses showed cytokeratin patterns fairly similar to those in the normal masticatory mucosa in cases of reactive hyperkeratosis due to mechanical stimulatory action; however, in Lichen ruber planus they agreed only incompletely. The site-specific, normally stably expressed cytokeratins of the mucosa-type concerned were likewise regularly demonstrable in the pathologically changed tissue specimens under study, except cytokeratin no. 1 which is known to be a reliable indicator of keratinocyte cornification merely in orthological but not in pathological conditions. Deviating from the normal cytokeratin pattern in the oral mucosa, a more frequent and more expressed occurrence of cytokeratins no. 17 and 18 was observed in Lichen ruber planus. In 4 extraordinarily reactive hyperkeratoses, among these 2 papillomas the cytokeratins no. 7/13 were present.
Ermich
T
T
Department of Maxillo-Facial and Plastic Surgery, Friedrich Schiller University, Bachstrasse, Jena, DDR.
Schulz
J
J
Raabe
G
G
Schumann
D
D
D001706:Biopsy; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D006801:Humans; D007633:Keratins / Q000302:isolation & purification*; D008010:Lichen Planus / Q000378:metabolism* / Q000473:pathology; D008970:Molecular Weight; D009059:Mouth Diseases / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000032:analysis* / Q000473:pathology
D007633:Keratins