Antimutagenic effects of taurine in a bacterial assay system.
Taurine (2-aminoethanesulfonic acid) was evaluated as an antimutagen in the Ames Salmonella tester strain assay. Taurine inhibited mutagenesis by doxorubicin (-74%), bleomycin (-55%), mitomycin C (-56%), and 2-aminofluorene (-52%), but not danthrone or benzo(a)pyrene, in strain TA102. In strain TA98, doxorubicin mutagenicity, but not that of 2-aminofluorene or benzo(a)pyrene, was inhibited by taurine. N-Methyl-N'-nitro-N-nitrosoguanidine (-73%), but not dexon, mutagenicity was inhibited by taurine in strain TA100. Taurine inhibited those mutagens against which it was effective in a dose-related fashion. Taurine was more effective in inhibiting doxorubicin mutagenicity in strain TA102 than its analogues hypotaurine, beta-alanine, and guanidinoethanesulfonic acid or alanine or glycine. The observed inhibition may indicate a role for taurine in modulating the activity of oxidant species.
Laidlaw
S A
SA
Department of Medicine, School of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Dietrich
M F
MF
Lamtenzan
M P
MP
Vargas
H I
HI
Block
J B
JB
Kopple
J D
JD
D000596:Amino Acids / Q000494:pharmacology; D001557:Benzenesulfonates / Q000037:antagonists & inhibitors; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D001761:Bleomycin / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000037:antagonists & inhibitors; D005449:Fluorenes; D008769:Methylnitronitrosoguanidine; D016685:Mitomycin; D008937:Mitomycins / Q000037:antagonists & inhibitors; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D012486:Salmonella typhimurium / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology*
D000596:Amino Acids; D001557:Benzenesulfonates; D005449:Fluorenes; D008937:Mitomycins; D009153:Mutagens; D001761:Bleomycin; D008769:Methylnitronitrosoguanidine; D013654:Taurine; C007287:dexon (fungicide), sodium salt; D001564:Benzo(a)pyrene; C012177:2-aminofluorene; D016685:Mitomycin; D004317:Doxorubicin