A comparison of benflurone effects after intravenous infusion or oral administration. A study on laboratory rats.
The effects of oral administration and intravenous infusion of benflurone were compared using the single dose of 100 mg/kg b.w. Oral administration of benflurone induced more moderate changes in both white and red blood picture than the equal dose of orally administered cyclophosphamide. In contrast to oral benflurone administration, intravenous benflurone induced deep anaemia, deep reticulocytopenia, transient neutrophilia and slight decrease in small lymphocyte counts. The recovery from intravenous benfluorone effects was rapid.
Berger
J
J
Laboratory of Haematology, Research Institute for Pharmacy and Biochemistry, Pardubice, CSSR.
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000494:pharmacology; D004920:Erythropoiesis / Q000187:drug effects; D005449:Fluorenes / Q000008:administration & dosage*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D009503:Neutropenia / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000187:drug effects
D000970:Antineoplastic Agents; D005449:Fluorenes; C034234:VUFB 13468; D003520:Cyclophosphamide