title: Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
abstract: Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.
authors: University College London, Department of Genetics and Biometry.
authors: K
authors: K
authors: Tsioupra
authors: L F
authors: LF
authors: West
authors: M B
authors: MB
authors: Davis
authors: J M
authors: JM
authors: Parrington
authors: J D
authors: JD
authors: Delhanty
mesh_terms: D000328:Adult; D001761:Bleomycin / Q000494:pharmacology; D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000032:analysis* / Q000187:drug effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D001761:Bleomycin; D008769:Methylnitronitrosoguanidine