title: Genetic heterogeneity of thalassemias in Mexican mestizo patients with hemolytic anemia.
abstract: Twenty-eight Hb abnormalities (16 thalassemias, 10 Hb variants and 2 hereditary persistences of fetal hemoglobin) were detected in an etiopathogenic search in 131 patients with hemolytic anemia. The observed thalassemic genotypes [6 beta(0)/beta, 2 (delta beta) (0)/beta(0), 2 beta(0)/beta(+), 2 beta(0)/beta(s), 2 beta(+)/beta(+), 1 beta(+)/beta(s) and 1 (delta beta)(0)/beta] showed heterogeneity in the population studied. A native origin of some of these mutations is considered.
authors: División de Genética, Instituto Mexicano del Seguro Social, Guadalajara.
authors: B
authors: B
authors: Ibarra
authors: G
authors: G
authors: Vaca
authors: E
authors: E
authors: de la Mora
authors: F
authors: F
authors: Romero
authors: C
authors: C
authors: Aguilar-Luna
authors: A
authors: A
authors: Mejía
authors: M A
authors: MA
authors: Esparza
authors: G
authors: G
authors: Pérez
authors: M L
authors: ML
authors: Ornelas
authors: J M
authors: JM
authors: Cantú
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology*; D005006:Ethnicity; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D007198:Indians, North American; D008297:Male; D008800:Mexico; D010375:Pedigree; D013030:Spain / Q000208:ethnology; D013789:Thalassemia / Q000150:complications / Q000208:ethnology / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal; D005914:Globins; D005319:Fetal Hemoglobin