Endothelin-1: contractile responses and autoradiographic localization of receptors in rabbit blood vessels.
Endothelin-1 (ET-1) elicits a contractile response from intact and endothelium-denuded rings of rabbit aorta and carotid artery. At low doses of ET-1, the response is attenuated in the presence of endothelium. The specific receptors that mediate the contractile response are located by autoradiography on the vascular smooth muscle although the decrease in response in intact rings may imply that they are also present on the endothelium.
Dashwood
M
M
Department of Physiology, Royal Free Hospital School of Medicine, London, England.
Turner
M
M
Jacobs
M
M
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001345:Autoradiography; D002339:Carotid Arteries / Q000187:drug effects; D016232:Endothelins; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D017466:Receptors, Endothelin
D016232:Endothelins; D010455:Peptides; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin