[Virus safety of labile plasma products from the German viewpoint].
Unstable plasma derivatives are sterilized in Germany according to three methods. Combined treatment with beta-propiolactone + UV irradiation: in use at Biotest since 1968; Pasteurisation in sulution, 10 h at 60 degrees C in the presence of a maltose-glycin stabilizer; in use at Behring Werke since 1980; Treatment with solvent + detergent (tri-n-butyl phosphate + Tween 80 (sodium cholate]: in use at DRK Hagen and Biotest since 1987/88. The safety of unstable plasma derivatives sterilized according to these methods has been shown in studies in chimpanzees as well as in clinical studies.
Stephan
W
W
Biotest Pharma, Frankfurt, Main, BRD.
D001793:Blood Preservation / Q000379:methods*; D001798:Blood Proteins; D001803:Blood Transfusion; D005860:Germany, West; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D012307:Risk Factors; D013242:Sterilization / Q000379:methods*
D001798:Blood Proteins
Virussicherheit labiler Plasmaprodukte aus deutscher Sicht.