The in vitro translation product of the murine lambda 5 gene contains a functional signal peptide.
We have isolated and sequenced a novel lambda 1 constant region related cDNA clone which might represent an allelic variant of the recently described lambda 5 gene. This lambda 5 transcript is present in pre-B cell lines and bone marrow cells, but not in B cell lines, plasma cell lines or in spleen cells. In vitro translation studies show that the translation product contains a signal peptide of approx. 30 amino acids at its N-terminus.
Jongstra
J
J
Department of Medical Microbiology, Stanford University School of Medicine, CA 94305.
Jongstra-Bilen
J
J
Tidmarsh
G F
GF
Davis
M M
MM
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D001483:Base Sequence; D004274:DNA, Recombinant; D005803:Genes, Immunoglobulin; D007147:Immunoglobulin Light Chains / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals / Q000096:biosynthesis*; D012313:RNA; D014178:Translocation, Genetic
D004274:DNA, Recombinant; D007147:Immunoglobulin Light Chains; D021382:Protein Sorting Signals; D012313:RNA