The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.
The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.
Rushlow
C A
CA
Department of Zoology, University of Oxford, UK.
Hogan
A
A
Pinchin
S M
SM
Howe
K M
KM
Lardelli
M
M
Ish-Horowicz
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D015152:Blotting, Northern; D003360:Cosmids; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D005796:Genes; D007301:Insect Hormones; D019476:Insect Proteins; D008969:Molecular Sequence Data; D009154:Mutation; D009857:Oncogenes; D010641:Phenotype; D012313:RNA / Q000235:genetics; D012097:Repressor Proteins; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic; D014162:Transfection
D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA; D029721:Drosophila Proteins; D007301:Insect Hormones; D019476:Insect Proteins; D012313:RNA; D012097:Repressor Proteins; D014157:Transcription Factors; C489235:hairy protein, Drosophila; C061841:hairy protein, insect