[Experimental studies of in vitro IFN induction by different polynucleotides in human cell culture systems].
Several polynucleotides were tested for interferon induction in comparison with the standard Poly (IC) in human diploid fibroblasts and in human leukocyte suspensions. We received high IFN-titre following superinduction of the polynucleotides in human fibroblasts. These results show that under superinduction conditions partly 3 times more interferon is induced in comparison with the standard inductor Poly (IC). The tested concentration of 10 micrograms/ml polynucleotides did not result in any IFN yields or only in very low ones in human leukocytes, which were only within the range of detectability.
Glück
B
B
Akademie der Wissenschaften der DDR.
Meister
W V
WV
Witkowski
W
W
Stelzner
A
A
Hoffmann
S
S
D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D011070:Poly I-C / Q000494:pharmacology; D011119:Polynucleotides / Q000494:pharmacology*
D011119:Polynucleotides; D007372:Interferons; D011070:Poly I-C
Experimentelle Untersuchungen zur in vitro-IFN-Induktion durch verschiedene Polynucleotide in humanen Zellkultur-Systemen.