Protection from chlordecone (Kepone)-potentiated CCl4 hepatotoxicity in rats by fructose 1,6-diphosphate.
1. The extent of liver injury assessed as elevation of plasma transaminases was decreased 40-50% by administration of fructose 1,6-diphosphate to rats receiving the highly hepatotoxic combination of chlordecone and CCl4. 2. This protection was accompanied by significantly higher sustenance of ATP levels in the liver. 3. Polyamine synthesis as well as interconversion were stimulated in favor of maintaining higher levels of polyamines. 4. These events are consistent with the concept that suppressed hepatocellular regeneration which leads to progression of otherwise limited injury observed in chlordecone potentiation of CCl4 hepatotoxicity is due to lack of cellular energy.
Rao
S B
SB
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505.
Mehendale
H M
HM
D000123:Acetyltransferases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D007631:Chlordecone / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D005635:Fructosediphosphates / Q000378:metabolism / Q000627:therapeutic use*; D006598:Hexosediphosphates / Q000627:therapeutic use*; D007306:Insecticides / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D000255:Adenosine Triphosphate; D012437:Adenosylmethionine Decarboxylase; D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D002251:Carbon Tetrachloride; D007631:Chlordecone; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D007306:Insecticides; D009955:Ornithine Decarboxylase; D000099228:Diamine N-Acetyltransferase; C029063:fructose-1,6-diphosphate