Hemiballismus: changes in cerebrospinal fluid.
Concentrations of serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and dopamine metabolites, homovanillic acid (HVA) and 3,4-dihydroxy-phenylacetic acid (DOPAC), were measured in the samples of cerebrospinal fluid of 5 patients with acute hemiballismus. The only significant change was the increased content of HVA compared to controls. This finding support the hypothesis on the increased dopamine turnover in hemiballismus and provide a rational basis for the present treatment with antidopaminergic agents.
Kostic
V
V
Department of Neurology, School of Medicine, Belgrade, Yugoslavia.
Djuricic
B
B
Paschen
W
W
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid*; D000368:Aged; D004292:Dominance, Cerebral / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000134:cerebrospinal fluid*; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011954:Receptors, Dopamine / Q000502:physiology; D013786:Thalamic Diseases / Q000134:cerebrospinal fluid*; D013787:Thalamic Nuclei / Q000503:physiopathology*
D010648:Phenylacetates; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid