The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.
In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes.
Escande
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D
Laboratory of Cellular Electrophysiology, Rhône-Poulenc Santé, Gennevilliers, France.
Thuringer
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D
Leguern
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S
Cavero
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I
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D005905:Glyburide / Q000494:pharmacology; D006168:Guinea Pigs; D007473:Ion Channels / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*
D001578:Benzopyrans; D007473:Ion Channels; D011758:Pyrroles; D019806:Cromakalim; D000255:Adenosine Triphosphate; D011188:Potassium; D005905:Glyburide