[Mutagenic effect of pesticides fastac 10 EK and durs ban 4E studied in a micronucleus test iin mouse bone marrow cells].
The mutagenic activity of vastak and durs ban pesticides was studied by the micronucleus test in mouse bone marrow. The frequency of micronuclei in polychromatic erythrocytes was tested at 24, 36 and 42 h after oral administration of 50% LD50 dose of vastak (14 mg/kg) and durs ban (30.5 mg/kg). Significantly different increase in micronucleated polychromatic erythrocytes was established at 24, 36 and 48 h after vastak administration, and at 24 and 36 h after durs ban treatment. Doses of 25% LD50 for both pesticides showed no mutagenic activity, as judged by the induction of micronuclei in polychromatic erythrocytes.
Benova
D K
DK
Institute of Nuclear Medicine, Radiobiology and Radiation Hygiene, Medical Academy of Bulgaria, Sofia.
Rupova
I M
IM
Iagova
A Kh
AKh
Bineva
M V
MV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D004390:Chlorpyrifos / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens; D011722:Pyrethrins / Q000633:toxicity*
D007306:Insecticides; D009153:Mutagens; D011722:Pyrethrins; C017160:cypermethrin; D004390:Chlorpyrifos
Mutagennyĭ éffekt pestitsidov vaztak 10 EK i durs ban 4E, ustanovlennyĭ putem mikroiadernogo testa v kostnomozgovykh kletkakh myshi.