Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells. Especially, four clonally related leukemic lines that were established independently from the same patient with adult T cell leukemia expressed different combinations of lymphokine mRNAs, indicating that the expression of various lymphokines is not fixed but rather variable even among progenies of a single T cell clone.
Noma
T
T
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Nakakubo
H
H
Sugita
M
M
Kumagai
S
S
Maeda
M
M
Shimizu
A
A
Honjo
T
T
D002999:Clone Cells; D015342:DNA Probes; D005786:Gene Expression Regulation; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics; D015847:Interleukin-4; D007378:Interleukins / Q000096:biosynthesis / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000032:analysis; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D015342:DNA Probes; D007376:Interleukin-2; D007378:Interleukins; D012333:RNA, Messenger; D015847:Interleukin-4; D011061:Poly A; D012313:RNA