Phenobarbital rheumatism in patients with brain tumor.
We reviewed the charts of 429 patients with primary brain tumors treated at Memorial Sloan-Kettering Cancer Center to determine the frequency, clinical characteristics, and provocative factors involved in the development of the shoulder-hand syndrome. Five percent (20/429) of patients developed this syndrome, which was strongly associated with phenobarbital use (p less than 0.0001) and often produced more short-term disability than the brain tumor itself.
Taylor
L P
LP
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Posner
J B
JB
D001932:Brain Neoplasms / Q000188:drug therapy; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D012019:Reflex Sympathetic Dystrophy / Q000139:chemically induced*
D010634:Phenobarbital