title: Evidence for posttranslational control of fetal hemoglobin synthesis.
abstract: Subunit competition experiments were conducted by recombining various amounts of alpha-subunits with an equimolar mixture of gamma- and beta A-subunits. The results showed that gamma-subunits combine with alpha-subunits less readily than beta A-subunits. Thus, in the presence of alpha-chain deficiency (alpha-thalassemia) the formation of HbA is preferred over HbF, resulting in a decrease in the level of the latter.
authors: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
authors: C C
authors: CC
authors: Qiu
authors: E C
authors: EC
authors: Abraham
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005319:Fetal Hemoglobin / Q000032:analysis / Q000096:biosynthesis* / Q000145:classification; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D014176:Protein Biosynthesis; D013789:Thalassemia / Q000097:blood*
chemical_list: D006441:Hemoglobin A; D005319:Fetal Hemoglobin