Comparison of a human T-cell lymphotropic virus type I strain from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis with a prototype human T-cell lymphotropic virus type I.
The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis is described. The virus isolate is a typical type C retrovirus as seen by electron microscopy and is related to prototype HTLV-I isolated from patients with adult T-cell leukemia but is not identical to this prototype HTLV-I as seen by restriction enzyme mapping.
Sarin
P S
PS
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892.
Rodgers-Johnson
P
P
Sun
D K
DK
Thornton
A H
AH
Morgan
O S
OS
Gibbs
W N
WN
Mora
C
C
McKhann
G
G
Gajdusek
D C
DC
Gibbs
C J
CJ
D000368:Aged; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis; D015480:Deltaretrovirus Antibodies / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D015368:Human T-lymphotropic virus 1 / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007563:Jamaica; D015458:Leukemia, T-Cell / Q000382:microbiology; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008854:Microscopy, Electron; D015493:Paraparesis, Tropical Spastic / Q000276:immunology / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis
D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies; D012194:RNA-Directed DNA Polymerase; D004262:DNA Restriction Enzymes