title: [Pharmacokinetic characteristics of 6-azacytidine].
abstract: Pharmacokinetics of 6-azacytidine, an antitumour drug, is studied by ion-pair reversed-phase highly effective liquid chromatography. The survey of the drug elimination from blood is of a two-phase character: the first phase--with a biological half-life of 5.5 min (for rats) and 6.5 min (for rabbits); the second phase--1.2 and 2.5 h, respectively. For a 24 h period 75% of the drug is excreted unchanged in the urine.
authors: N A
authors: NA
authors: Petrusha
authors: S V
authors: SV
authors: Galushko
authors: I P
authors: IP
authors: Shishkina
mesh_terms: D000818:Animals; D001374:Azacitidine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D001374:Azacitidine; C040881:6-azacytidine
vernacular_title: Osobennosti farmakokinetiki 6-azatsitidina.