title: [Brain metastases. Radiologic diagnosis and therapy].
abstract: Brain metastasis is a sign of advanced malignant disease. The grave clinical symptoms demand an immediate and accurate diagnosis and effective palliation. Computer-assisted tomography with contrast enhancement is the most established diagnostic procedure, and the number and size of the metastases can be determined, as well as indirect signs of increased intracranial pressure. The treatment of choice for multiple brain metastases is whole-brain irradiation. The symptomatic responses range between 60% and 80%, with a median survival of about 5 months. Survival in individual cases however, is mainly influenced by the histology of the primary tumor, as well as the general condition of the patient and the progression of the extracerebral disease. Prophylactic brain irradiation in patients with small-cell lung cancer and a good response to chemotherapy significantly decreases the incidence of symptomatic metastases in patients and yields longer survival times. Larger treatment doses per fraction and simultaneous application of chemotherapy may enhance the risk of late neurological sequelae.
authors: Abteilung Klinische Radiologie mit Poliklinik, Radiologischen Universitätsklinik Heidelberg.
authors: M
authors: M
authors: Flentje
authors: J
authors: J
authors: Görich
authors: M
authors: M
authors: Wannenmacher
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D003131:Combined Modality Therapy; D006801:Humans; D010166:Palliative Care; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Hirnmetastasen. Radiologische Diagnostik und Therapie.