title: Pattern of ribonucleic acid synthesis in vitro in primary spermatocytes from mouse testis carrying an X-autosome translocation.
abstract: In an attempt to elucidate the mechanism of sterility of X-autosome translocations in the mouse, we studied the distribution of [3H]-uridine incorporation in sterile males carrying the balanced X-16 reciprocal translocation. The results failed to show an overall reactivation of the X as has been postulated by Lifschytz and Lindsley (1972) but there was some spreading of X inactivation along the translocated and normal chromosome 16 in those regions that were close to the X breakpoint. We feel that this process could be responsible for metabolic disturbances leading to degeneration of primary spermatocytes and, therefore, to sterility.
authors: Institut d'Embryologie, Faculté de Médecine, Strasbourg, France.
authors: H
authors: H
authors: Jaafar
authors: O
authors: O
authors: Gabriel-Robez
authors: Y
authors: Y
authors: Rumpler
mesh_terms: D000818:Animals; D001345:Autoradiography; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D012313:RNA / Q000096:biosynthesis*; D013094:Spermatozoa / Q000378:metabolism*; D013737:Testis / Q000378:metabolism; D014178:Translocation, Genetic; D014960:X Chromosome
chemical_list: D012313:RNA