Dystrophin and the integrity of the sarcolemma in Duchenne muscular dystrophy.
It is suggested that in Duchenne muscular dystrophy the absence of dystrophin, which is probably a cytoskeletal protein underlying the sarcolemma, causes changes in stretch-activated cation channels rather than direct mechanical tearing of the surface membrane.
Duncan
C J
CJ
Department of Zoology, University of Liverpool, England.
D000818:Animals; D016189:Dystrophin; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology*; D009132:Muscles / Q000473:pathology / Q000503:physiopathology; D009136:Muscular Dystrophies / Q000473:pathology / Q000503:physiopathology*; D012508:Sarcolemma / Q000473:pathology / Q000502:physiology*
D016189:Dystrophin; D007473:Ion Channels; D009124:Muscle Proteins