The orientation of the adenovirus fiber and its anchor domain identified through molecular mimicry.
An antibody prepared against a synthetic peptide derived from the sequence of the adenovirus protease cross-reacted with the viral fiber protein of adenovirus types 2, 3, 4, and 9. Four residues in a conserved hexamer sequence near the N-terminus of the Ad2 and Ad3 fibers were homologous to the peptide. The epitope was masked by attachment of the penton base and thus lies within an anchoring domain 30 residues from the N-terminus of the fiber polypeptide.
Weber
J M
JM
Department of Microbiology, Université de Sherbrooke, Québec, Canada.
Talbot
B G
BG
Delorme
L
L
D000256:Adenoviridae / Q000276:immunology*; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology*; D015153:Blotting, Western; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000276:immunology; D011233:Precipitin Tests
D000914:Antibodies, Viral; D036022:Capsid Proteins; D000939:Epitopes; C018315:hexon capsid protein, Adenovirus; D010447:Peptide Hydrolases