Vasoactive intestinal peptide interacts with alpha-adrenergic-, cholinergic-, and substance-P-mediated responses in rat parotid and submandibular glands.
Secretory dose-response curves were obtained with both acetylcholine and phenylephrine treatment in rat parotid and submandibular glands. Vasoactive intestinal peptide (VIP), which produced relatively low volumes of protein-rich saliva in rat salivary glands, also enhanced acetylcholine-, phenylephrine-, and substance-P-mediated fluid and protein secretion when administered in combination with these agents. The specific mechanisms involved in the synergistic actions of VIP with substances such as acetylcholine, phenylephrine, and substance P, which are primarily linked to the production of fluid secretion in rat salivary glands, have yet to be determined.
Bobyock
E
E
Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102.
Chernick
W S
WS
D000109:Acetylcholine / Q000494:pharmacology*; D000681:Amylases / Q000032:analysis; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D012471:Salivary Proteins and Peptides; D010656:Phenylephrine; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D000681:Amylases; D000109:Acetylcholine