[Cardiovascular reactions and histamine release following atracurium--a problem of dosage?].
All muscle relaxants can induce allergic or pseudo-allergic reactions. The medium-long-acting, nondepolarizing muscle relaxant atracurium has been shown to be a potent histamine liberator. Up to now it is unknown if a clinical dosage of atracurium exists where no clinically relevant histamine release occurs. In a prospectively controlled study we therefore investigated the effects of different dosages of atracurium on cardiovascular reactions and histamine release.
Tryba
M
M
Universitätsklinik für Anaesthesiologie, Intensiv- und Schmerztherapie, Bergmannsheil Bochum.
Triene
M
M
Wruck
G
G
Zenz
M
M
D000328:Adult; D001279:Atracurium / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation
D001279:Atracurium
Kardiovaskuläre Reaktionen und Histaminfreisetzung nach Atracurium--ein Problem der Dosis?