[Electrophysiological changes of the excitoconduction system in patients with Chagas cardiomyopathy and their modification by flecainide].
We studied 20 patients with a confirmed diagnosis of Chagas heart disease. Clinical and electrocardiography examinations at baseline documented that all patients had chronic PVC's and that 40% of them also had supraventricular extrasystoles. Also 80% of the patients had RBBB's, 70% had LBBB's and 35% had 1st. degree AV blocks. Flecainide (F) completely suppressed the arrhythmias in 85% of the patients and did partially so in 98% of the patients. Flecainide did not affect sinus node function except in one patient who developed a sinus node atrial block. PR and QRS intervals were prolonged after F but there no 2nd or 3rd degree AV blocks. Flecainide demonstrated to be highly effective with a comfortable margin of safety in the management of these patients with marked alterations of their pace-making and conduction functions.
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Cátedra de Farmacología, Facultad de Ciencia Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Carrizo Paez
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Derlis Abate
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D000293:Adolescent; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D001919:Bradycardia / Q000188:drug therapy; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D002598:Chagas Cardiomyopathy / Q000150:complications / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000627:therapeutic use*; D006327:Heart Block / Q000188:drug therapy; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005424:Flecainide
Estudio de las alteraciones electrofisiológicas del sistema excitoconductor en pacientes con miocardiopatía Chagásica y las modificaciones determinadas por la flecainida.