[A new anti-arrhythmia drug. II. Comparative studies of the effects of a new acyl derivative of procainamide, procainamide and N-acetylprocainamide on blood pressure and the electrocardiogram in rabbits].
In the recent years a remarkable number of new antiarrhythmic drugs have been introduced, but their side effects limit the application. Procainamide (PA) and N-acetylprocainamide (Acekainide, NAPA) display many undesired side effects, too. It was assumed that N-propionyl-procainamide, having antiarrhythmic activity, might display less unfavourable effects on arterial blood pressure, heart rate and heart conduction system in rabbits, because of blockade of the primary aromatic amine group. The obtained results were subjected to statistical analysis. It has been stated that N-propionylprocainamide decreases the arterial blood pressure in rabbits to a lesser extent than procainamide. Moreover, in contrast with the latter compound, N-propionylprocainamide accelerates the heart rate, but does not influence the atrio-ventricular conduction, and does not prolong the ventricular refraction time. Antiarrhythmic activity of N-propionylprocainamide, not being inferior to that of procainamide and N-acetylprocainamide, and lesser side effects of N-propionylprocainamide indicate for advisability of further studies of this compound.
Kusowska
J
J
D000120:Acecainide / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D011342:Procainamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits
C059135:N-propionylprocainamide; D000120:Acecainide; D011342:Procainamide
Nowy lek antyarytmiczny. II. Wpływ nowej N-acylowej pochodnej prokainamidu na ciśnienie tetnicze krwi i elektrokardiogram królika w porównaniu z prokainamidem i N-acetyloprokainamidem.