title: Effect of enterosorption on animal lifespan.
abstract: Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.
authors: Institute of Gerontology AMS USSR.
authors: V V
authors: VV
authors: Frolkis
authors: V G
authors: VG
authors: Nikolaev
authors: G I
authors: GI
authors: Paramonova
authors: E V
authors: EV
authors: Shchorbitskaya
authors: L N
authors: LN
authors: Bogatskaya
authors: A S
authors: AS
authors: Stupina
authors: A I
authors: AI
authors: Kovtun
authors: V E
authors: VE
authors: Sabko
authors: V M
authors: VM
authors: Shaposhnikov
authors: K K
authors: KK
authors: Muradian
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008136:Longevity / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000648:ultrastructure; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: C029814:SKN hemosorbents; D002606:Charcoal; D012313:RNA