[The effect of stress on interferon production in mice].
In order to study the effect of stress on the interferon (IFN) production, we determined the IFN-alpha/beta and -gamma producing capacities in restraint-stressed and SART-stressed mice. Restraint-stress caused not only a significant reduction in body weight, but also a reduction in the weight of spleen. The IFN-alpha/beta producing capacity by Newcastle disease virus (NDV) was significantly lower in the stressed mice. The IFN-gamma producing capacity by both Con-A and PHA-P was also depressed by this stress. On the other hand, SART-stress, whose severity was thought to be mild because no loss of body and spleen weights was seen, did not affect IFN-alpha/beta and -gamma producing capacities. These results suggest that the suppression of IFN producing capacity is dependent on the severity of physical stress.
Kita
M
M
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
Iwaki
H
H
Kitoh
I
I
Imanishi
J
J
D000818:Animals; D001835:Body Weight; D007370:Interferon Type I / Q000032:analysis; D007371:Interferon-gamma / Q000032:analysis; D007372:Interferons / Q000032:analysis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology; D013314:Stress, Mechanical; D013312:Stress, Physiological / Q000378:metabolism* / Q000473:pathology; D013315:Stress, Psychological
D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons
Effet du stress sur la production de l'interféron chez la souris.