title: Analysis of the feline immune response to human myelin-associated glycoprotein.
abstract: Elucidation of the pathogenesis of demyelinating peripheral neuropathy associated with myelin-associated glycoprotein (MAG) binding IgM paraproteins requires an in vivo animal model of the syndrome. Multiple immunizations of cats with MAG in Freund's adjuvant did not produce an antibody response but four immunizations with MAG-iscom (Morein, B. et al. (1984) Nature, 308: 457-460) did induce IgM antibodies which bound to human MAG and cat peripheral nerve myelin. Despite the presence of antibody for a 13-month period, no neuropathy developed. At necropsy, the peripheral nerves were ultrastructurally normal and no antibody was detectable in the endoneurium. A competitive ELISA indicated that the cat and human IgM antibodies recognized different epitopes.
authors: Department of Pathology, University of Pennsylvania, Philadelphia 19104.
authors: S N
authors: SN
authors: Kahn
authors: N L
authors: NL
authors: Stanton
authors: A J
authors: AJ
authors: Sumner
authors: M J
authors: MJ
authors: Brown
authors: S L
authors: SL
authors: Spitalnik
authors: B
authors: B
authors: Morein
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002415:Cats; D003711:Demyelinating Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein
chemical_list: D001323:Autoantibodies; D007148:Immunoglobulin mu-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein