Reactivity with the peripheral myelin glycoprotein P0 in serum from patients with monoclonal IgM gammopathy and polyneuropathy.
The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum that did not react with MAG also did not recognize P0. Furthermore, the neural adhesion molecules L1, N-CAM, and J1 were also recognized by the serum that reacted with MAG, while the L3 carbohydrate-carrying cell adhesion molecule AMOG was not recognized. These observations indicate a restricted specificity in carbohydrate reactivity of IgM paraproteins and implicate yet another and, for the first time, peripheral myelin-specific glycoprotein in the pathogenesis of demyelinating neuropathy.
Bollensen
E
E
Department of Neurobiology, University of Heidelberg, Federal Republic of Germany.
Steck
A J
AJ
Schachner
M
M
D000911:Antibodies, Monoclonal / Q000276:immunology; D002241:Carbohydrates / Q000276:immunology; D003711:Demyelinating Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood* / Q000150:complications / Q000276:immunology; D007075:Immunoglobulin M; D007694:Killer Cells, Natural / Q000276:immunology; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000097:blood* / Q000276:immunology
D000911:Antibodies, Monoclonal; D002241:Carbohydrates; D000939:Epitopes; D007075:Immunoglobulin M; D018993:Myelin P0 Protein; D009185:Myelin Proteins