[Lactate dehydrogenase isoenzymes in radiation therapy of cancer patients].
Changes in the lactate dehydrogenase (LDH) isozymic spectrum have been examined in the patients with Stages I-III malignant tumors of the uterus before radiation therapy, during radiation reactions, and after these reactions have been remedied with polydesum and aminocaproic acid. A comparative analysis has shown that the blood serum LDH isozymic spectrum is changed in oncologic patients mainly at the expense of increased content of LDH4 and LDH5. Radiation reactions are associated with a considerable reduction of LDH1 activity and an essential rise of LDH3 and LDH4 activities, and an insignificant elevation of LDH2. The detected shifts in LDH isozymic spectrum during radiation reactions appear to be due to radiation toxemia. Detoxifying therapy with polydesum and epsilon-aminocaproic acid during 3-5 days helped normalize the LDH isozymic ratio.
Klimov
I A
IA
Serdiukov
A S
AS
Elistratova
N B
NB
D000368:Aged; D000614:Aminocaproates / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008875:Middle Aged; D011142:Polyvinyl Alcohol / Q000627:therapeutic use; D011832:Radiation Injuries / Q000188:drug therapy / Q000201:enzymology*; D012965:Sodium Chloride / Q000627:therapeutic use; D014115:Toxemia / Q000201:enzymology; D014594:Uterine Neoplasms / Q000532:radiotherapy*
D000614:Aminocaproates; D004338:Drug Combinations; D007527:Isoenzymes; C011324:polidez; D012965:Sodium Chloride; D011142:Polyvinyl Alcohol; D007770:L-Lactate Dehydrogenase
Izofermenty laktatdegidrogenazy pri luchevoĭ terapii u onkologicheskikh bol'nykh.