title: Modulation of synaptic transmission in autonomic ganglia mediated via the activation of postganglionic muscarinic M1 receptors.
abstract: The facilitatory actions of muscarine on synaptic transmission were measured in rat superior cervical ganglia in vitro. Muscarine (300 nmol/l) induced increases in submaximal population action potentials, which were mimicked by the M1 receptor agonist McN-A-343 (1 mumol/l) and antagonized by the M1 receptor antagonist pirenzepine (100 nmol/l) and telenzepine (100 nmol/l), but not by the M2 receptor antagonist AF-DX 116 (1 mumol/l). Slow excitatory postsynaptic potentials recorded from curarized rabbit isolated superior cervical ganglia were also blocked by telenzepine (300 nmol/l) but not by AF-DX 116 (3 mumol/l). It is concluded that M1 receptors mediate the excitatory actions of muscarinic agonists in these sympathetic ganglia.
authors: Department of Pharmacology, Byk Gulden Pharmaceuticals, Konstanz, FRG.
authors: M
authors: M
authors: Galvan
mesh_terms: D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005725:Ganglia, Autonomic / Q000187:drug effects / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009116:Muscarine / Q000494:pharmacology; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D011976:Receptors, Muscarinic; C046338:telenzepine; D010890:Pirenzepine; D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; D009116:Muscarine; C048593:otenzepad