title: Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure.
abstract: Acute ischemic left ventricular failure was induced in dogs by coronary embolization with plastic microspheres, resulting in reduced cardiac output (CO), increased left ventricular end-diastolic pressure (LVEDP), pulmonary capillary pressure (PCP), and total peripheral resistance (TPR). Intravenous (i.v.) administration of alifedrine, a beta-adrenergic partial agonist (0.3 mg/kg as bolus and 0.3 mg/kg/h as infusion), significantly improved performance of the failing heart. Left ventricular contractility was increased up to 50%, heart rate (HR) up to 28%, and CO up to 30%. LVEDP, PCP, and TPR were markedly decreased. Myocardial oxygen consumption was increased only to a minor degree despite the positive inotropic effect; coronary flow was augmented up to 26%. Thus, alifedrine in this model markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload.
authors: Department of Pharmacology, Biological Research, ASTA Pharma AG, Frankfurt (Main), F.R.G.
authors: P
authors: P
authors: Metzenauer
authors: R
authors: R
authors: Dedecke
authors: H
authors: H
authors: Göbel
authors: P A
authors: PA
authors: Martorana
authors: F
authors: F
authors: Stroman
authors: I
authors: I
authors: Szelenyi
mesh_terms: D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D008863:Microspheres; D010099:Oxyfedrine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011427:Propiophenones; D010099:Oxyfedrine; C039523:alifedrine