Liver cell carcinoma with orcein-positive granules and no identifiable copper.
A liver cell carcinoma removed surgically by partial hepatectomy from a 79-year-old woman contained abundant orcein-positive granules in many tumour cells. The granules were similar to those usually identified as representing copper-associated protein, yet they lacked copper, as demonstrated by negative rhodanine and rubeanic acid stains and energy dispersive X-ray microanalysis.
Shousha
S
S
Department of Histopathology, Charing Cross Hospital, London, UK.
Bull
T B
TB
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000648:ultrastructure; D003300:Copper / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008668:Metallothionein / Q000378:metabolism; D010078:Oxazines; D013194:Staining and Labeling
D010078:Oxazines; C007121:copper thionein; C002313:PAcein; D003300:Copper; D008668:Metallothionein