title: [The value of serologic inflammatory parameters in the diagnosis of alopecia areata].
abstract: Even recently, focal processes or inflammatory diseases have repeatedly been discussed as the possible causes of alopecia areata (AA) and corresponding diagnostic measures are still recommended. Therefore, we initially attempted to find definite indications of processes like these in AA patients by means of serologic parameters of inflammation and ESR as well as supplementary clinical focal diagnostics. The data obtained revealed increased titers of antistreptolysin in 2.9% and antistreptococcal DNase B in 25.7%, positive C-reactive protein in 8.6%, positive rheumatoid factor in 4.3%, and elevated ESR in 11.7% of the cases. After these data had carefully been compared to those in healthy persons, only the titer of antistreptococcal DNase B and the ESR were found to be increased. In the majority of the cases, these elevations correlated with concomitant bacterial infections detected by clinical focal diagnostics. Antistreptococcal DNase B titer and ESR seem to be the most appropriate of all our test parameters to provide some indications of a focal process or concomitant inflammatory diseases. The remaining parameters are not indicated in AA.
authors: Haut- und Poliklinik der Rheinischen Friedrich-Wilhelms-Universität Bonn.
authors: G
authors: G
authors: Lutz
authors: J
authors: J
authors: Stefan
authors: H
authors: H
authors: Niedecken
authors: H W
authors: HW
authors: Kreysel
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000506:Alopecia Areata / Q000097:blood / Q000209:etiology*; D000989:Antistreptolysin / Q000378:metabolism; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D000989:Antistreptolysin; D002097:C-Reactive Protein; D012217:Rheumatoid Factor; D003851:Deoxyribonucleases; C020069:deoxyribonuclease B
vernacular_title: Die Wertigkeit serologischer Entzündungsparameter in der Diagnostik der Alopecia areata.