Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.
In an attempt to clone protein tyrosine kinases, antiphosphotyrosine antibodies were used to screen lambda gt11 cDNA expression libraries. By this method, a 2.5-kilobase cDNA encoding a novel tyrosine kinase was isolated from a mouse liver cDNA library. This new gene is most closely related to the receptor tyrosine kinases ret, fms, and kit.
Kornbluth
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S
Rockefeller University, New York, New York 10021-6399.
Paulson
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KE
Hanafusa
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H
D000595:Amino Acid Sequence; D000906:Antibodies; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology
D000906:Antibodies; D019000:Phosphotyrosine; D014443:Tyrosine; D004247:DNA; D011505:Protein-Tyrosine Kinases