Occlusion of experimental artery aneurysms by intrasaccular injection of fibrin sealant.
Aneurysms were produced by grafting a vein pouch onto the cervical carotid artery of rabbits following the removal of an elliptical piece of the arterial wall. The diameter of the opening was 3-4 mm and the maximum height 8 mm. Through direct puncture of the aneurysm a clot of the fibrin sealant Tissucol was injected into the aneurysm. The sequential morphological changes were studied by light microscopy. One case was examined after 3 weeks by scanning electron microscopy. Complete resorption of the fibrin sealant was observed. The aneurysm cavity was filled with a dense connective tissue covered by a layer of newly formed endothelial cells.
Moringlane
J R
JR
Department of Stereotactic Neurosurgery, University of the Saarland, Federal Republic of Germany.
Grote
R
R
Vonnahme
F J
FJ
Mestres
P
P
Harbauer
G
G
Ostertag
C B
CB
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002339:Carotid Arteries / Q000648:ultrastructure; D004338:Drug Combinations / Q000494:pharmacology; D005176:Factor XIII / Q000494:pharmacology*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D002532:Intracranial Aneurysm / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin