title: Alpha-smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles.
abstract: Actin isoform expression may change during development, and in certain physiological, experimental and pathological situations. It is accepted that during sarcomeric (skeletal and cardiac) muscle development, the alpha-skeletal and alpha-cardiac isoforms of actin accumulate rapidly at the onset of muscle fibre formation, while there is a rapid fall in the expression of nonmuscle (beta and gamma) actin isoforms. Here we show that, before birth, both skeletal and myocardial cells express significant amounts of alpha-smooth muscle actin mRNA and protein. This expression is transient and disappears over the 1-7 days following birth. Our findings show that the program regulating actin isoform expression in sarcomeric muscle development is complex and that alpha-smooth muscle actin participates in this process.
authors: Department of Physiology and Biophysics, University of Vermont, Burlington 05405.
authors: J
authors: J
authors: Woodcock-Mitchell
authors: J J
authors: JJ
authors: Mitchell
authors: R B
authors: RB
authors: Low
authors: M
authors: M
authors: Kieny
authors: P
authors: P
authors: Sengel
authors: L
authors: L
authors: Rubbia
authors: O
authors: O
authors: Skalli
authors: B
authors: B
authors: Jackson
authors: G
authors: G
authors: Gabbiani
mesh_terms: D000199:Actins / Q000096:biosynthesis / Q000235:genetics*; D000375:Aging; D000818:Animals; D005455:Fluorescent Antibody Technique; D006321:Heart / Q000196:embryology* / Q000254:growth & development; D007124:Immunoenzyme Techniques; D024510:Muscle Development; D009130:Muscle, Smooth / Q000378:metabolism*; D009132:Muscles / Q000196:embryology* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012313:RNA / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000199:Actins; D012333:RNA, Messenger; D012313:RNA