title: Spine density on olfactory granule cell dendrites is reduced in rats reared in a restricted olfactory environment.
abstract: The Golgi technique was used to study the development of spines on the external dendrites of granule cells in the olfactory bulbs of young rats that had been continuously exposed to cyclohexanone vapor, deodorized air, or rat odors. Exposure to deodorized air for 3 weeks from postnatal day 1 reduced spine density on the medial and lateral sides of the bulb, whilst exposure to cyclohexanone reduced spine density on the lateral side only. These reductions were evident in other animals exposed for 7 weeks. With all treatments, spine density reached a maximum at postnatal day 21 and decreased markedly during the next month.
authors: Institute fur Hygiene and Arbeitsmedizin, Universitatsklinikum Essen, F.R.G.
authors: B
authors: B
authors: Rehn
authors: H
authors: H
authors: Panhuber
authors: D G
authors: DG
authors: Laing
authors: W
authors: W
authors: Breipohl
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003512:Cyclohexanones; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D009812:Odorants; D009830:Olfactory Bulb / Q000254:growth & development / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver; D013194:Staining and Labeling; D013569:Synapses / Q000502:physiology*
chemical_list: D003512:Cyclohexanones; D012834:Silver; C036468:cyclohexanone