Regulation of calcium influx by second messengers in rat mast cells.
Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosis.
Penner
R
R
Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FRG.
Matthews
G
G
Neher
E
E
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology; D004553:Electric Conductivity; D005089:Exocytosis / Q000187:drug effects; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D013373:Substance P / Q000494:pharmacology; D013403:Sugar Phosphates / Q000494:pharmacology*; D013873:Thionucleotides / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D002712:Chlorides; D007295:Inositol Phosphates; D007473:Ion Channels; D013403:Sugar Phosphates; D013873:Thionucleotides; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D013373:Substance P; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D003189:p-Methoxy-N-methylphenethylamine; D004533:Egtazic Acid; D015544:Inositol 1,4,5-Trisphosphate; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D002118:Calcium