Differentiation inducers of human myeloid leukaemia cell lines.
This review summarizes the recent studies of induced maturation in human myeloid Leukaemia cell lines and provides a list of differentiation inducers. The effect of differentiating agents on each human myeloid Leukaemia cell line is analysed. This review examines the importance of using combinations of the differentiating agents to overcome the maturation block in human myeloid leukaemia. The mechanisms of induction of differentiation are reviewed.
Hassan
H T
HT
Department of Haematological Medicine, University of Cambridge Clinical School, England.
D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006133:Growth Substances; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*
D006133:Growth Substances