Medulloblastoma in association with the Coffin-Siris syndrome.
An 8-year old patient with Coffin-Siris syndrome is presented, who was found to have a medulloblastoma during the evaluation of apnea and ventilator dependency. Although several cases of Dandy Walker cysts and one case of brain-stem heterotopia have been described in this rare syndrome, this is the first report of medulloblastoma in a patient with Coffin-Siris syndrome. Possible pathogenetic mechanisms are briefly discussed.
Rogers
L
L
Department of Neurosurgery, University of Mississippi Medical Center, Jackson 39216-4505.
Pattisapu
J
J
Smith
R R
RR
Parker
P
P
D000015:Abnormalities, Multiple / Q000150:complications*; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D003388:Cranial Fossa, Posterior; D002658:Developmental Disabilities / Q000150:complications*; D005260:Female; D005385:Fingers / Q000002:abnormalities; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D007592:Joint Diseases / Q000150:complications*; D008527:Medulloblastoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D009264:Nails, Malformed; D011859:Radiography; D013577:Syndrome; D014034:Toes / Q000002:abnormalities