Conditional open and delay time histograms of sodium channels.
Currents through single sodium channels were recorded in neuroblastoma cells. Open time histograms were constructed from openings which appeared between 2.0 and 5.0 ms after the onset of the depolarization. Histograms constructed from openings which were not preceded by other openings showed a maximum at t greater than 0 in contrast to those, which were preceded by other openings. Time constants of delay time histograms fitted by the sum of two exponentials were different for the first, second and third records of runs. The results support the view that sodium channels have multiple open and closed states and the transition probabilities among the states depend on local conditions of the membrane.
Nagy
K
K
I. Physiologisches Institut des Universität des Saarlandes, Homburg, F.R.G.
D000818:Animals; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials; D009441:Neurilemma / Q000502:physiology*; D009447:Neuroblastoma; D012964:Sodium / Q000502:physiology*; D014407:Tumor Cells, Cultured
D007473:Ion Channels; D012964:Sodium