[Diagnosis and prevention of myocardial reperfusion injury in experimental myocardial infarction].
In an experimental study in 69 dogs with the occluded anterior descending branch of the left coronary artery, dibunol, an antioxidant, and isoptin, a Ca2+ antagonist reduced myocardial infarction area, prolonged survival time and brought down mortality rate, in spite of an increase in reperfusion-related arrhythmias. The value of various electrocardiographic parameters for the diagnosis of ischemized-myocardium reperfusion and the severity of reperfusion-related heart damage in relation to the type of preventive medication, as compared to postmortem findings, are discussed.
Rudnev
D V
DV
Pichigin
V V
VV
Konorev
E A
EA
Konorev
L A
LA
Polumiskov
V Iu
VIu
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D005117:Cardiac Complexes, Premature / Q000175:diagnosis / Q000517:prevention & control*; D003250:Constriction; D004285:Dogs; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis / Q000517:prevention & control*; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D002084:Butylated Hydroxytoluene; D014700:Verapamil
Diagnostika i profilaktika reperfuzionnogo povrezhdeniia miokarda v usloviiakh eksperimental'nogo infarkta miokarda.