Bradykinin induced wheal and flare is not mediated by histamine release or cyclooxygenase products.
The wheal and flare response to intradermal bradykinin was studied in man. The possibility that histamine and cyclooxygenase products are involved in the response to bradykinin was examined. Terfenadine given by mouth significantly inhibited the cutaneous response to histamine but the effect of bradykinin was unaltered. Similarly the cutaneous response to bradykinin was unchanged by aspirin.
Crossman
D C
DC
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
Fuller
R W
RW
D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001920:Bradykinin; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012882:Skin Tests; D016593:Terfenadine
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D006632:Histamine; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin; D001920:Bradykinin