title: Regulation of the number of alpha-bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist.
abstract: Calcium has been suggested as the second messenger link between skeletal muscle activity and AChR gene expression and synthesis. We have compared the concentrations of the Ca2+ channel antagonists D600 and nisoldipine needed both to block Ca2+ uptake into cultured myotubes and to increase AChR expression. The good correspondence between these two measurements and the use of the highly specific Ca2+ channel antagonist nisoldipine strengthens the hypothesis that AChR expression is regulated by levels of intracellular Ca2+.
authors: Department of Pharmacology, University of Connecticut Health Center, Farmington 06032.
authors: H
authors: H
authors: Smilowitz
authors: E
authors: E
authors: Smart
authors: C
authors: C
authors: Bowik
authors: R J
authors: RJ
authors: Chang
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D005711:Gallopamil / Q000494:pharmacology*; D007700:Kinetics; D009132:Muscles / Q000378:metabolism*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D015737:Nisoldipine; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002038:Bungarotoxins; D002121:Calcium Channel Blockers; D011950:Receptors, Cholinergic; D005711:Gallopamil; D015737:Nisoldipine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009543:Nifedipine; D002118:Calcium