[Endometrial findings in long-term treatment with synthetic sex steroids in Turner syndrome].
In 9 patients with Turner's syndrome (karyotype 45/X0) aged from 23 to 50 years (average age 34 years) a curettage was performed. In these women there has been a treatment with mestranol 80 micrograms or ethinylestradiol 50 micrograms and chlormadinome acetate 2 mg as a sequential therapy in a cyclic manner for 5 to 22 years. Additionally in 3 patients a biopsy from the uterine cervix was performed because of abnormal colposcopic findings. Only in one patient an atrophic endometrium was found, whereas in the other patients the endometrium showed a weak proliferation or a slight secretion. Ectasia of the endometrial glands was observed in 4 patients. A hyperplastic endometrium wasn't found in any patient.
Rudolf
K
K
Klinik für Gynäkologie und Geburtshilfe, Wilhelm-Pieck-Universität Rostock.
Rohde
E
E
Rüting
M
M
Gerber
B
B
D000328:Adult; D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004714:Endometrial Hyperplasia / Q000139:chemically induced; D004717:Endometrium / Q000187:drug effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008656:Mestranol / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011127:Polyps / Q000139:chemically induced; D014424:Turner Syndrome / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000139:chemically induced
D002715:Chlormadinone Acetate; D004997:Ethinyl Estradiol; D008656:Mestranol
Endometriumbefunde unter Langzeitbehandlung mit synthetischen Sexualsteroiden beim Turner-Syndrom.