[Expression of HLA-Dr and CD1+ cells in malignant and benign pigmentary tumors].
The authors studied the expression of CD1 and HLA-Dr antigen in benign and malignant melanic tumors to known if were the melanoma's cells or Langerhans cells, presents on the tumor, which exhibited the HLA-Dr antigens, and if the HLA-Dr expression was related to volume, depth and metastatic characteristics. These antigens were studied with the monoclonal antibodies labelled to avidin-biotin-peroxidase system. The results shows than the proportion between the number of Langerhans cells and HLA-Dr positive cells is inverse. No differences were found between the expression of the HLA-Dr antigens and number of Langerhans cells and volume, depth or metastatic characteristics.
Ramírez-Bosca
A
A
Servicio de Dermatología, Hospital Clínico Universitario, Facultad de Medicina, Valencia.
Valcuende-Cavero
F
F
Rufat-Pérez
M J
MJ
Castells-Rodellas
A
A
D018949:Antigens, CD1; D000943:Antigens, Differentiation / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology*; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D009508:Nevus, Pigmented / Q000276:immunology* / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
D018949:Antigens, CD1; D000943:Antigens, Differentiation; D006684:HLA-DR Antigens
Expresión del HLA-Dr y células CD1+ en tumores pigmentarios malignos y benignos.