Cutaneous late phase responses--an allergic inflammatory response.
Cutaneous late phase responses have been demonstrated to occur secondary to either immune or nonimmune mast cell activation. In this article I will review studies from our laboratory that support the concept that inflammatory cells, migrating into the allergic reaction secondary to mast cell activation, are themselves activated. These activated cells release mediators that then can induce edematous, indurated cutaneous responses occurring hours after mast cell activation that have been termed "late phase cutaneous responses."
Atkins
P C
PC
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
D000937:Antigen-Antibody Reactions / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D001768:Blister / Q000276:immunology; D006636:Histamine Release / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008407:Mast Cells / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism; D012867:Skin / Q000276:immunology*; D013997:Time Factors
D000941:Antigens