title: An analysis of the effects of galanin on gastric acid secretion and plasma levels of gastrin in the dog.
abstract: The effects of galanin on gastric acid secretion and plasma levels of gastrin were studied in conscious dogs chronically fitted with gastric fistulas. Continuous i.v. infusion of galanin (2 micrograms.kg-1.h-1) for 2 h did not affect unstimulated total acid output or plasma levels of gastrin. In contrast, simultaneous i.v. infusion of galanin (1-2 micrograms.kg-1.h-1) inhibited the bombesin-stimulated output of acid whereas the effects of bombesin on gastrin output were not significantly modified. Galanin (2-4 micrograms.kg-1 i.v.) also depressed the secretory response to 2-deoxy-D-glucose without significantly affecting plasma gastrin levels. Galanin (2-4 micrograms.kg-1 i.v.) did not depress bethanechol-stimulated gastric acid output or inhibit histamine-stimulated gastric acid secretion. These findings indicate that glanin inhibits the bombesin- and 2-deoxy-D-glucose-stimulated secretion of gastric acid in conscious dogs by an action which is probably exerted at the level of the cholinergic nerve terminals.
authors: Laboratory of Veterinary Pharmacology, University of Pisa, Italy.
authors: G
authors: G
authors: Soldani
authors: G
authors: G
authors: Mengozzi
authors: A
authors: A
authors: Della Longa
authors: L
authors: L
authors: Intorre
authors: F
authors: F
authors: Martelli
authors: D R
authors: DR
authors: Brown
mesh_terms: D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D001839:Bombesin / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology; D003847:Deoxyglucose / Q000494:pharmacology; D004285:Dogs; D005260:Female; D019004:Galanin; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D008297:Male; D010455:Peptides / Q000494:pharmacology*
chemical_list: D001626:Bethanechol Compounds; D005755:Gastrins; D010455:Peptides; D019004:Galanin; D003847:Deoxyglucose; D001839:Bombesin