Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections.
Treatment of mice infected with Rauscher (RMLV) or Friend (FMLV) murine leukemia viruses at an early stage of disease (beginning at day 0 and continuing every other day for 21 days) with 5 x 10(7) units/kg body weight of a cross-species-active recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D) was more effective in FMLV than in RMLV infections. In contrast, treatment with 5 x 10(7) units/kg body weight of IFN beginning as late as 15 days postinfection and continuing every other day for 21 days was more effective in RMLV than in FMLV infections. These differences were consistent with observed changes in circulating white blood cells, spleen weight, and reverse transcriptase levels. Additionally, biweekly long-term administration (beginning at day 0) of 5 x 10(6) units/kg of rHuIFN-alpha B/D (an ineffective treatment in short-term therapy) significantly prolonged the mean survival time of RMLV-infected mice, but only weakly prolonged that of FMLV-infected mice.
Gangemi
J D
JD
Research Laboratories, Pharmaceuticals Division, CIBA-GEIGY Ltd., Basel, Switzerland.
Matter
A
A
Poncioni
B
B
Hochkeppel
H K
HK
D000818:Animals; D004334:Drug Administration Schedule; D005622:Friend murine leukemia virus / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007370:Interferon Type I / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000517:prevention & control* / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009929:Organ Size; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D011925:Rauscher Virus / Q000187:drug effects; D011994:Recombinant Proteins; D013154:Spleen / Q000033:anatomy & histology; D013997:Time Factors; D014762:Viral Interference; D014776:Virus Cultivation
D007370:Interferon Type I; D011994:Recombinant Proteins; D012194:RNA-Directed DNA Polymerase