Expression of T-cell-receptor beta chain in Reed-Sternberg cells.
Frozen and paraffin sections of biopsy specimens from 65 patients with Hodgkin's disease were immunostained with the monoclonal antibody beta F1, which recognises a formol-resistant framework epitope on the T-cell-receptor beta chain (TCR-beta)--a structure that defines T cells. In 14 patients a subpopulation of Hodgkin and Reed-Sternberg cells showed beta F1 positivity, usually on the surface membrane, in both frozen and paraffin sections. TCR-beta-positive Hodgkin and Reed-Sternberg cells occurred in all types of Hodgkin's disease except the lymphocyte-predominant subtype.
Dallenbach
F E
FE
Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, West Germany.
Stein
H
H
D000911:Antibodies, Monoclonal; D002462:Cell Membrane / Q000473:pathology; D000939:Epitopes / Q000032:analysis*; D005615:Freezing; D006644:Histiocytes / Q000166:cytology / Q000276:immunology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D010232:Paraffin; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D010232:Paraffin