Sudden sensorineural hearing loss influence of hemodynamical and hemorheological factors on spontaneous recovery and therapy results.
The effect of a hemodilution therapy for sudden sensorineural hearing loss was analysed comparing the results of a prospective randomised double blind study and a retrospective study at the Frankfurt university. The prospective study consists of a treatment group receiving infusions with hydroxyethyl starch-pentoxifyllin and a control group with infusions with normal saline. Another patient group receiving hydroxyethyl starch-pentoxifyllin-naftidrofuryl infusions was analysed retrospectively. The overall therapy results are in the same range for all 3 groups. However patients with a hemoglobin value above 14 mg % in the control group had a poorer result compared to the other groups. The patient group with systolic blood pressure above 130 mm Hg treated with hydroxyethyl starch-pentoxifyllin had a significant hearing improvement over normal saline and hydroxyethyl starch-pentoxifyllin-naftidrofuryl. With increasing systolic blood pressure, patients in the control and hydroxyethyl starch-pentoxifyllin-naftidrofuryl groups had a statistically significant lower therapy result.
Desloovere
C
C
Department of Otorhinolaryngology, University of Frankfurt, West-Germany.
Lörz
M
M
Klima
A
A
D000208:Acute Disease; D001794:Blood Pressure; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004432:Ear, Middle / Q000098:blood supply; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology* / Q000628:therapy; D006438:Hemodilution; D006439:Hemodynamics; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D008833:Microcirculation; D009257:Nafronyl / Q000008:administration & dosage; D010431:Pentoxifylline / Q000008:administration & dosage; D011446:Prospective Studies; D011897:Random Allocation; D012189:Retrospective Studies
D006895:Hydroxyethyl Starch Derivatives; D009257:Nafronyl; D010431:Pentoxifylline