Influence of anticoagulants on the determination of interferon.
The presence of anticoagulants in plasma samples can spuriously increase the titers obtained in interferon bioassays by influencing interactions between the cell and the challenge virus. These artifacts can be eliminated by washing the test cell cultures before the virus challenge is added.
Lodemann
E
E
Zentrum der Biologischen Chemie der Universität, Abteilung für Therapeutische Biochemie, Frankfurt/Main, FRG.
Lehr
G
G
D000925:Anticoagulants / Q000097:blood / Q000494:pharmacology*; D003637:DEAE-Dextran / Q000097:blood / Q000494:pharmacology; D016264:Dextran Sulfate; D003911:Dextrans / Q000097:blood / Q000494:pharmacology; D004492:Edetic Acid / Q000097:blood / Q000494:pharmacology; D005189:False Positive Reactions; D006493:Heparin / Q000097:blood / Q000494:pharmacology; D006801:Humans; D007372:Interferons / Q000097:blood*
D000925:Anticoagulants; D003911:Dextrans; D006493:Heparin; D007372:Interferons; D003637:DEAE-Dextran; D016264:Dextran Sulfate; D004492:Edetic Acid