[Morphometric characteristics of the cells in non-tumoral processes and tumors of the adrenal glands].
A comparative morphometric study of the cells was carried out by the Integral-2MT television cytologic analyzer, and the DNA quantitative estimation by flow cytofluorometry in 31 patients with adrenal tumors and hyperplastic involvements. The shifts in all the morphometric parameters in cortical adenoma and hyperplasia were found statistically insignificant, with similar (diploid) DNA cytograms. The differences in all the morphometric parameters (except the cellular and nuclear shape) were statistically significant in pheochromocytoma and hyperplasia of the cortex, with the pheochromocytoma DNA histograms showing higher counts of cells with DNA content higher than 2S. Assessment of the total group of malignant tumors of the adrenals (malignant pheochromocytoma, cortical carcinoma) has shown statistically significant differences in the mean characteristics (except cellular and nuclear shape) of these tumors and adrenocortical hyperplasia. In adrenocortical carcinoma 2 of the 3 histograms were aneuploid with a considerable count of cells with DNA content higher than 2S. The objective parameters may be used in the differential cytologic diagnosis of nontumor involvements and tumors of the adrenals.
Smol'ianinova
N V
NV
Shapiro
N A
NA
Isakov
V L
VL
D000236:Adenoma / Q000473:pathology*; D000306:Adrenal Cortex Neoplasms / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D010673:Pheochromocytoma / Q000473:pathology*
Morfometricheskie osobennosti kletok pri neopukholevykh protsessakh i opukholiakh nadpochechnikov.