Changes of glycogen metabolism in phosphorylcreatine-depleted muscles taken from rats fed with beta-guanidine propionate.
Changes in glycogen metabolism were explored in fast and slow muscles taken from rats fed with a diet containing 1% beta-guanidine propionate (GPA), a synthetic analog that inhibits the entry of creatine into muscle cells competitively and causes phosphorylcreatine depletion. Feeding with the GPA-containing diet increased glycogen levels in the two types of muscles to a different extent and with different temporal patterns; it did not change significantly the rate of glycogen turnover both at rest and during exercise; it did not affect the net degradation of glycogen during exercise. Diet could affect the activity of several enzymes of sugar metabolism. These latter changes too were different in fast-twitch and in slow-twitch muscles.
De Tata
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Istituto di Patologia Generale, Pisa.
Gori Bergamini
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Bergamini
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D000818:Animals; D006003:Glycogen / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006593:Hexokinase / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism*; D010732:Phosphofructokinase-1 / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006146:Guanidines; D011422:Propionates; D010725:Phosphocreatine; D006003:Glycogen; D006005:Phosphorylases; D006006:Glycogen Synthase; D006593:Hexokinase; D010732:Phosphofructokinase-1; C005775:guanidinopropionic acid