title: Proteolytic degradation of desmosomes in plantar stratum corneum leads to cell dissociation in vitro.
abstract: Pieces of plantar stratum corneum were incubated with trypsin. This resulted in cell dissociation. The only observable ultrastructural change caused by trypsin was a degradation of desmosomal plates between dissociating cells. This suggests that desmosomes are of primary importance in plantar stratum corneum cell adhesion.
authors: Department of Dermatology, University Hospital, Umeå, Sweden.
authors: T
authors: T
authors: Egelrud
authors: P A
authors: PA
authors: Hofer
authors: A
authors: A
authors: Lundström
mesh_terms: D003896:Desmosomes / Q000187:drug effects / Q000648:ultrastructure*; D005528:Foot; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D012867:Skin / Q000166:cytology* / Q000187:drug effects; D014357:Trypsin / Q000378:metabolism*
chemical_list: D014357:Trypsin