Effect of continuous infusion of bleomycin on the time for completion of repair of sublethal radiation damage in mouse lip mucosa during fractionated irradiation.
The influence of a simultaneous continuous infusion of bleomycin on the time necessary for repair of sublethal radiation damage during fractionated irradiation of mouse lip mucosa was studied. Although there are strong indications that bleomycin interferes with the accumulation and repair of sublethal radiation damage, no significant change in the time course of these repair processes could be demonstrated following various analyses of the experimental results. An interval of at most 4 h between successive irradiations was sufficient to allow for a similar amount of repair of sublethal damage as compared with either 24 h (2 fractions) or 6 h (10 fractions), whether or not radiation was combined with bleomycin infusion.
Vanuytsel
L
L
Department of Experimental Radiotherapy, University Hospital St. -Rafaël, Leuven, Belgium.
Feng
Y
Y
Landuyt
W
W
Thames
H D
HD
van der Schueren
E
E
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008046:Lip / Q000187:drug effects / Q000528:radiation effects*; D009061:Mouth Mucosa / Q000187:drug effects / Q000528:radiation effects*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D013997:Time Factors
D001761:Bleomycin