[Effect of the neurosensitization of female rats on the functional indices of the DNA-, RNA- and protein-synthesizing neuronal apparatus of the cerebral cortex and of the immune system in their progeny].
Neurosensitization effects on the state of the ribonucleoprotein particles and chromatin in nuclei of the Vth layer cortical neurons were studied in female rats. Anti-brain antibodies were investigated in their offspring on the 30th and 60th days. On the 60th day the electron-cytochemical changes were found in the nuclei suggesting the deterioration of nucleolar DNA processing and inhibition of nucleolar functional activity. Anti-brain antibodies were also found in the blood. Direct antibodies interference in the function of cellular DNA-RNA-protein-synthetizing system seems plausible.
Kolomeets
N S
NS
Konokotina
G F
GF
Kazakova
P B
PB
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000032:analysis; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D006651:Histocytochemistry; D007107:Immune System / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007114:Immunization; D008854:Microscopy, Electron; D009044:Motor Cortex / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D000906:Antibodies; D000941:Antigens; D009419:Nerve Tissue Proteins; D012313:RNA; D004247:DNA
Vliianie neĭrosensibilizatsii samok krys na nekotorye pokazateli sostoianiia DNK-RNK-beloksinteziruiushchego apparata neĭronov kory golovnogo mozga i immunnoĭ sistemy u potomstva.