Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.
Beta-adrenoceptor blocking (BAB) drugs perturb the membranes of isolated rat mast cells. Membrane fluidisation was temperature dependent and was determined by the liposolubility of the BAB drugs. The secretory index, evaluated as the ratio between histamine liberation and degranulation, correlated with the membrane order parameter of the mast cell membranes. The rank order of potency for mast cell activation and membrane fluidisation was: exaprolol greater than propranolol greater than metipranolol greater than atenolol.
Nosál
R
R
Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Drábiková
K
K
Pecivová
J
J
Ondrias
K
K
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects*; D051381:Rats; D012995:Solubility; D013696:Temperature
D000319:Adrenergic beta-Antagonists