Multiple uncommon chromosome abnormalities in acute myelomonocytic leukemia (AMMoL-M4) with rapid progression.
We observed multiple uncommon chromosome abnormalities resulting in marker formation in a patient with AMMoL-M4. The breakpoints of the aberrations corresponded to common "cancer breakpoints" described by Mitelman and also--to localisation of some protooncogenes. The activation of these multiple protooncogenes in the described case might result in rapid progression of the disease and in the resistance to therapy.
Haus
O
O
Department of Pathophysiology, Medical Academy, Wrocław, Poland.
Podolak-Dawidziak
M
M
Sasiadek
M
M
Plewa
R
R
Chichłowska-Sliwińska
M
M
D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D009857:Oncogenes; D013997:Time Factors