title: Fibroblast growth factor and angiogenesis.
abstract: Basic and acidic fibroblast growth factors (bFGF and aFGF, respectively) are prototypes of the family of fibroblast growth factors which also includes products of the HSTF1/KS3, INT2 and FGF5 oncogenes. bFGF and aFGF have a broad spectrum of tissue distribution, target cells and bioactivities. Both factors also stimulate the migration and proliferation of capillary endothelial cells, a process named angiogenesis. It is conceivable that bFGF and aFGF contribute in as essential manner to angiogenesis. These properties may have therapeutical implications.
authors: Dept. of Hematology, Children's University Hospital, Heidelberg, FRG.
authors: L
authors: L
authors: Schweigerer
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D009857:Oncogenes / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor
chemical_list: D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors