title: Poly(ADP-ribose) polymerase activity is inhibited by 2',5'-oligoadenylates in mouse L-cells.
abstract: Down regulation of poly(ADP-ribose)polymerase (ADPRP) activity was observed in mouse LW-cells after treatment with 2'-5'oligoadenylates or with fibroblast interferon and poly(rI) poly(rC). The poly(rI) poly(rC)-induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2',5'-oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.
authors: Centro Richerche Sclavo, Siena, Italy.
authors: D T
authors: DT
authors: Buonamassa
authors: M
authors: M
authors: Malanga
authors: E M
authors: EM
authors: Coccia
authors: G
authors: G
authors: Romeo
authors: E
authors: E
authors: Affabris
authors: B
authors: B
authors: Farina
authors: H
authors: H
authors: Suzuki
mesh_terms: D000227:Adenine Nucleotides / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D007372:Interferons / Q000494:pharmacology; D007739:L Cells / Q000201:enzymology*; D051379:Mice; D009843:Oligoribonucleotides / Q000032:analysis / Q000494:pharmacology*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C023505:2',5'-oligoadenylate; D007372:Interferons