title: Potential involvement of galanin in the regulation of fluid homeostasis in the rat.
abstract: A physiological role for galanin, a 29-amino acid neuropeptide, has not been established. However, anatomical studies have demonstrated the presence of galanin in brain regions associated with the control of water balance in the rat, most notably in the paraventricular nucleus (PVN) of the hypothalamus and the neurointermediate lobe of the pituitary gland (NIL). In the PVN, galanin coexists with arginine vasopressin (AVP) in magnocellular neurons. The present study demonstrates that homozygous Brattleboro rats, which lack AVP, produce galanin. Galanin concentrations in the median eminence (ME) of the homozygous Brattleboro rat do not differ from the galanin concentrations in the ME of either heterozygous Brattleboro or Sprague-Dawley rats. However, galanin concentrations in the NIL of the homozygous Brattleboro rat were reduced by 75%. Similarly, dehydration induced by salt-loading reduced galanin concentrations in the NIL and produced transient changes in the ME. These data demonstrate that galanin concentrations are influenced by changes in fluid homeostasis and suggest that galanin may be an important component in the regulation of neurohypophyseal function and AVP secretion.
authors: Department of Neurology, Massachusetts General Hospital, Boston 02114.
authors: J I
authors: JI
authors: Koenig
authors: S
authors: S
authors: Hooi
authors: S M
authors: SM
authors: Gabriel
authors: J B
authors: JB
authors: Martin
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000032:analysis; D003681:Dehydration / Q000503:physiopathology; D019004:Galanin; D008297:Male; D008473:Median Eminence / Q000032:analysis; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis / Q000187:drug effects; D010455:Peptides / Q000032:analysis / Q000502:physiology*; D010902:Pituitary Gland / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D010455:Peptides; D001127:Arginine Vasopressin; D019004:Galanin