title: The effects of 5-azacytidine, 12-O-tetradecanoylphorbol 13-acetate and sodium n-butyrate on reactivation of alphaherpesvirus saimiri from explant cultures of latently infected rabbit dorsal root ganglia.
abstract: The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (alpha HVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of alpha HVS in Vero cells. 12-O-Tetradecanoylphorbol 13-acetate (a protein kinase C activator) and sodium n-butyrate both had a stimulating action on replication in Vero cells but did not affect the release of alpha HVS from latently infected rabbit dorsal root ganglia.
authors: Department of Medical Microbiology, University of Liverpool, U.K.
authors: S P
authors: SP
authors: Mossman
authors: D A
authors: DA
authors: Leib
authors: K
authors: K
authors: McCarthy
authors: C A
authors: CA
authors: Hart
mesh_terms: D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D005727:Ganglia, Spinal / Q000382:microbiology*; D006567:Herpesvirus 2, Saimiriine / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity; D011817:Rabbits; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014774:Virulence; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D002087:Butyrates; D020148:Butyric Acid; D001374:Azacitidine; D013755:Tetradecanoylphorbol Acetate