title: [The effect of fibrin glue on the healing of hydroxyapatite ceramics. An animal experiment study].
abstract: Calcium phosphate ceramics have been proposed for obliteration of the mastoid cavity in middle ear surgery. To our knowledge no experimental data are available concerning the use of homologous fibrin glue associated with hydroxyapatite (HA) in animals. Obliteration of the epitympanic space and closure of defects in the femur of rabbits by HA granules with and without homologous fibrin glue were performed on 17 animals, and the animals followed up for 2 weeks to 6 months. X-ray and histological examinations of the tissue integration of the implants were performed by semi-quantitative measurements. Fibrin glue accelerates the development of soft tissue and slows down the osteointegration of the ceramic implants.
authors: Universitäts-Hals-Nasen-Ohrenklinik Mainz.
authors: R
authors: R
authors: Reck
authors: M
authors: M
authors: Bernal-Sprekelsen
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D001861:Bone Regeneration / Q000187:drug effects; D002516:Ceramics; D004338:Drug Combinations / Q000008:administration & dosage; D017886:Durapatite; D004432:Ear, Middle / Q000601:surgery*; D005176:Factor XIII / Q000008:administration & dosage*; D005269:Femur / Q000601:surgery; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D006097:Granulation Tissue / Q000187:drug effects; D006882:Hydroxyapatites; D019736:Prostheses and Implants; D011817:Rabbits; D013917:Thrombin / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D006882:Hydroxyapatites; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D017886:Durapatite; D013917:Thrombin
vernacular_title: Der Einfluss von Fibrinkleber auf die Einheilung von Hydroxylapatit-Keramik. Eine tierexperimentelle Studie.