Identification of a second interferon-regulated murine Mx gene.
The murine influenza virus resistance locus Mx consists of more than one interferon-responsive transcription unit. We isolated clones of the transcripts of a second Mx gene (Mx2) which is closely linked to the well-characterized resistance gene and determined their sequences. Mx2 mRNA is more than 90% identical to Mx1 mRNA in the region corresponding to the amino termini of the encoded proteins. Mx2 mRNAs of mouse strains BALB/c and CBA have open reading frames apparently interrupted by mutations. Interferon-treated cells from strain A2G and other influenza virus-resistant strains failed to express detectable amounts of Mx2 transcripts.
Staeheli
P
P
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Sutcliffe
J G
JG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D019204:GTP-Binding Proteins; D005786:Gene Expression Regulation; D005796:Genes; D007113:Immunity, Innate; D007372:Interferons / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008969:Molecular Sequence Data; D064547:Myxovirus Resistance Proteins; D011506:Proteins / Q000235:genetics*
C579070:Mx1 protein, mouse; C579067:Mx2 protein, mouse; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D004247:DNA; D007372:Interferons; D019204:GTP-Binding Proteins