Human prostate-specific antigen (APS) is a member of the glandular kallikrein gene family at 19q13.
The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein-like family is localized in a single locus on chromosome 7, while other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q13, concordant with the renal kallikrein KLK1 gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.
Sutherland
G R
GR
Department of Histopathology, Adelaide Children's Hospital, S.A.
Baker
E
E
Hyland
V J
VJ
Callen
D F
DF
Close
J A
JA
Tregear
G W
GW
Evans
B A
BA
Richards
R I
RI
D000951:Antigens, Neoplasm / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000276:immunology / Q000648:ultrastructure*; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005786:Gene Expression Regulation; D006801:Humans; D007610:Kallikreins / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011467:Prostate / Q000166:cytology / Q000378:metabolism; D017430:Prostate-Specific Antigen; D012689:Sequence Homology, Nucleic Acid
D000951:Antigens, Neoplasm; D015342:DNA Probes; D004247:DNA; D007610:Kallikreins; D017430:Prostate-Specific Antigen