Suppressive effect of camostat mesilate (FOY 305) on acute experimental allergic encephalomyelitis (EAE).
Camostat mesilate (FOY305), a synthetic serine protease inhibitor and has been developed as a drug for pancreatitis, is effective in suppressing acute experimental allergic encephalomyelitis in Lewis rats. Loss of weight, clinical score and yield of myelin protein from brain stem were improved by daily injection of FOY305 compared with saline from day 6 after inoculation with homogenate of guinea pig spinal cord. A significant decrease of yield of myelin has been shown here for the first time in acute EAE in Lewis rat. This is in accord with myelin breakdown demonstrated morphologically. Our study also demonstrates a significant improvement of yield of myelin protein by FOY305. Our results suggest the possibility of a clinical application of this protease inhibitor for human demyelinating diseases such as multiple sclerosis.
Inuzuka
T
T
Department of Neurology, Niigata University, Japan.
Sato
S
S
Baba
H
H
Miyatake
T
T
D000818:Animals; D001921:Brain / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004952:Esters; D016670:Gabexate / Q000031:analogs & derivatives*; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D004676:Myelin Basic Protein / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew
D004952:Esters; D006146:Guanidines; D004676:Myelin Basic Protein; D011480:Protease Inhibitors; C034532:camostat; D016670:Gabexate