[Effects of essentiale forte on biosynthesis of nucleic acids and several hemodynamic parameters of the damaged myocardium in rabbits].
Normalization of heart muscle phospholipid metabolism and reactivation of the activity of membrane-bound enzymes participating in the reactions of biosynthesis of nucleic acids have been studied. These investigations were carried out under the conditions of experimental myocardial infarction. The effects of essential forte have been examined when it was combined with both a tocopherol, and sodium nucleinate. It was pointed out that essential forte using without other reagents leads to the depression of nucleic acids biosynthesis in affected heart muscle, while the combinations of it with a-tocopherol, and especially with sodium nucleinate are accompanied by the significant intensification of reactions of formation of desoxynucleic and ribonucleic acids biosynthesis in necrotic areas as well as in peripheral regions of affected myocardial tissue. These positive changes are accompanied also by the pronounced normalization of haemodynamic activity of infarcted myocardium.
Karagezian
K G
KG
Engibarian
A A
AA
Varosian
M A
MA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D009203:Myocardial Infarction / Q000378:metabolism*; D009696:Nucleic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D014810:Vitamin E / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000924:Anticholesteremic Agents; D009696:Nucleic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D010975:Platelet Aggregation Inhibitors; C011246:essential 303 forte; D014810:Vitamin E; D012313:RNA; D004247:DNA; C013683:sodium nucleinate
Vliianie éssentsiale-forte na biosintez nukleinovykh kislot i nekotorye gemodinamicheskie pokazateli povrezhdennogo miokarda krolikov.