Pregnancy-associated protein-A does not improve predictability of pregnancy success or failure over human chorionic gonadotropin levels in early normal and abnormal pregnancy.
In the present study we sought to compare levels of PAPP-A and hCG produced by different types of pregnancy: normal, ectopic, threatened abortion and molar pregnancy after evacuation. The gestations ranged from 13 to 122 days. Serum levels of both PAPP-A and hCG were measured and compared. Chi squares analysis were predictive only for increasing trends in hCG as well as decreasing trends of both hCG and PAPP-A. Analysis of variance and linear discriminant function used to evaluate results suggested that PAPP-A did not improve predictability of hCG. The values of PAPP-A levels for the postevacuation molar pregnancies barely exceeded the lower limit of detection; thus, no meaningful comparisons could be made.
Coddington
C C
CC
Eastern Virginia Medical School, Medical College of Hampton Roads, Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Norfolk 23510.
Sinosich
M J
MJ
Boston
E G
EG
Bartko
J J
JJ
Hodgen
G D
GD
D000033:Abortion, Threatened / Q000097:blood; D000704:Analysis of Variance; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005544:Forecasting; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011252:Pregnancy Complications, Neoplastic / Q000097:blood; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000378:metabolism*; D011271:Pregnancy, Ectopic / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011863:Radioimmunoassay; D012016:Reference Values; D014328:Trophoblastic Neoplasms / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood
D006063:Chorionic Gonadotropin; D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A