A class of non-selective cation channels in human fibroblasts.
Non-selective cation channels were detected in membrane patches of cultured human fibroblasts. The channels had a unitary conductance which ranged from 14 to 25 pS in symmetrical 130 mM NaCl and were permeable to both sodium and potassium ions. Open channel probability was dependent either on the membrane potential and the Ca2+ concentration on the intracellular side of the membrane. High Ca2+ concentrations in the millimolar range were needed to keep the channel active.
Galietta
L J
LJ
Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
Mastrocola
T
T
Nobile
M
M
D002118:Calcium / Q000502:physiology; D002412:Cations; D004553:Electric Conductivity; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials
D002412:Cations; D007473:Ion Channels; D002118:Calcium