Partial hepatectomy augments the liver's antitumor response.
Despite adequate locoregional control, colorectal metastasis to the liver remains a significant cause of death. Resection of hepatic metastasis improves five-year survival 18% to 34%. A study of the impact of 40% partial hepatectomy on cytokine production in the liver was undertaken. Nonparenchymal liver cells (NPCs) were prepared by collagenase perfusion and metrizamide gradient from partially hepatectomized and laparotomized control C57BL/6Ros mice. Nonparenchymal cell from partially hepatectomized mice compared with laparotomized mice showed a twofold to threefold increase in interferon (IFN) activity. Both interferon alpha/beta and supernatants from cultured NPCs of partially hepatectomized mice suppressed the proliferation of liver-derived MCA-38 colon adenocarcinoma cells in vitro. This tumor has been shown to metastasize to the liver of C57BL/6Ros mice. The production of various cytokines by NPCs induced by partial hepatectomy may provide a possible antimetastatic mechanism.
Doerr
R
R
Department of Surgery, State University of New York, Buffalo.
Castillo
M
M
Evans
P
P
Paolini
N
N
Goldrosen
M
M
Cohen
S A
SA
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D003110:Colonic Neoplasms / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D006498:Hepatectomy / Q000379:methods; D007372:Interferons / Q000096:biosynthesis; D008099:Liver / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary* / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D007372:Interferons