Expression of "cell-cycle-dependent" genes in regenerating rat liver.
The expression of genes coding for the ATP/ADP translocase, calcyclin, ornithine decarboxylase, vimentin, proto-onc genes p53 and c-Ha-ras1 and also for two genes JE and KC with as yet unknown function was studied during regeneration of rat liver. Genes highly induced were: JE (2-8 h of regeneration), ATP/ADP translocase (8-18 h), c-Ha-ras-1 (6-48 h) and p53 (6-12 h). Vimentin and KC gene transcripts were not detectable in the first 48 h of liver regeneration, whereas ornithine decarboxylase and calcyclin gene transcripts were present at constant levels. Our findings extend the list of genes expressed at the early stages of liver regeneration.
Biesiada
E
E
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Chorazy
M
M
D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics; D002453:Cell Cycle; D005786:Gene Expression Regulation; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D000226:Mitochondrial ADP, ATP Translocases / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009955:Ornithine Decarboxylase / Q000235:genetics; D011519:Proto-Oncogenes; D012313:RNA / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; D012313:RNA; D000226:Mitochondrial ADP, ATP Translocases; D009955:Ornithine Decarboxylase