Dietary vitamin E supplement does not inhibit changes in lung pressure-volume characteristics produced by bleomycin in hamsters.
We tested the hypothesis that a dietary supplement of vitamin E (VE) may lessen changes in pulmonary pressure-volume characteristics induced by intratracheal instillation of bleomycin. Ninety-nine male hamsters were separated into a control group (C), a VE supplement group (E), a control plus bleomycin group (CB) and a VE supplement plus bleomycin group (EB). Animals were killed at 30, 40, 55, 70 and 90 days and the pressure-volume curves of their lungs, both air-filled and saline-filled, were determined. Bleomycin was instilled on the thirtieth day. Lung volumes, compliance and curve-fitting data were compared. The mean serum VE concentration was 17.5 micrograms.ml-1 in groups E and EB as compared to 5.7 micrograms.ml-1 in groups C and CB. Despite the remarkably high VE content, no significant difference was found between groups CB and EB for the parameters compared.
Sato
S
S
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Nakamura
H
H
Takada
K
K
Takahashi
K
K
D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D006224:Cricetinae; D004032:Diet; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008647:Mesocricetus; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000517:prevention & control; D014810:Vitamin E / Q000627:therapeutic use*
D001761:Bleomycin; D014810:Vitamin E