Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits.
The deduced amino acid sequences of cDNA clones encoding human GABAA receptor alpha 1 and beta 1 subunits are presented. The human subunits display very high levels of sequence identity with the corresponding bovine receptor subunits. The cloned human GABAA receptor subunits induce the formation of GABA-gated chloride channels when expressed in mammalian cells.
Schofield
P R
PR
Zentrum für Molekulare Biologie, University of Heidelberg, FRG.
Pritchett
D B
DB
Sontheimer
H
H
Kettenmann
H
H
Seeburg
P H
PH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D018118:Chloride Channels; D002712:Chlorides / Q000502:physiology; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005333:Fetus; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D046911:Macromolecular Substances; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000502:physiology; D008969:Molecular Sequence Data; D011963:Receptors, GABA-A / Q000235:genetics*; D014162:Transfection; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018118:Chloride Channels; D002712:Chlorides; D007473:Ion Channels; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D004247:DNA