Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus.
A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulphate, which has negatively charged units. Selective removal of anti-dsDNA is expected to contribute not only to the treatment but also to elucidation of the pathogenesis of SLE.
Kinoshita
M
M
Division of Immunology, National Medical Center, Tokyo, Japan.
Aotsuka
S
S
Funahashi
T
T
Tani
N
N
Yokohari
R
R
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D004247:DNA / Q000032:analysis*; D016264:Dextran Sulfate; D003911:Dextrans / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000628:therapy; D008297:Male
D000974:Antibodies, Antinuclear; D003176:Complement C3; D003911:Dextrans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA; D016264:Dextran Sulfate