HLA linked immune response to S and pre-S2 gene products in hepatitis B vaccination.
In order to detect a possible HLA linked genetic control of human immune responses to hepatitis B virus, forty healthy adult persons of the same age typed for HLA-A, -B and -DR antigens, were vaccinated against virus hepatitis B and sequentially tested for anti-HBs and anti-pre-S2 antibodies. They received three injections of Hevac-B Pasteur vaccine, the second 1 month and the third 3 months after the first. Following the third immunization, 38 individuals (95%) had a protective level of anti-HBs antibodies and 17 (42.3%) had a positive level of anti-pre-S2 antibodies. HLA-A11 antigen was significantly more frequent (pc = 0.007) among anti-HBs high responders than low responders. In addition, anti-HBs high responders were more frequently HLA-DR1, and less frequently HLA-DR4 and DR7 positive; corrected values, however, were not significant. Anti-pre-S2 high responders showed an apparent increase of HLA-B7, B14 or DR3 antigens, when compared to low responders (pc not significant).
Marescot
M R
MR
Laboratoire d'Immunologie Cellulaire et Tissulaire Hôpital Pitié-Salpétrière, Paris, France.
Budkowska
A
A
Pillot
J
J
Debre
P
P
D000328:Adult; D000917:Antibody Formation; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000235:genetics* / Q000276:immunology; D017325:Hepatitis B Vaccines; D006801:Humans; D008297:Male; D010641:Phenotype; D011498:Protein Precursors / Q000235:genetics* / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011498:Protein Precursors; D014761:Viral Hepatitis Vaccines; C050807:presurface protein 2, hepatitis B surface antigen