Induction of cell mediated immune response by nonspecific stimulator of immunity against antigenically unrelated oncogenic virus (Marek's disease virus).
An enzyme treated preparation of Mycobacterium phlei (NSI), induced strong cell mediated immune response (CMIR) against specific as well as against nonspecific oncogenic Marek's disease (MDV) in birds, as evinced by Lymphocyte migration inhibition, (LMIT) lymphocyte transformation test (LT) and Lymphokine (Lymphocyte migration inhibition factor) LyIF assay. Maximum CMIR could be observed towards third week post inoculation. All the three tests exhibited a positive correlation. Such phenomenon of CMIR induction by NSI, nonspecifically to unrelated viral/cancerous diseases (MD) in birds generates hopes for immunoprevention of these maladies by utilizing such phenomenon.
Kishore
S
S
Mallick
B B
BB
D000276:Adjuvants, Immunologic; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002464:Cell Migration Inhibition; D002645:Chickens; D000939:Epitopes; D008381:Herpesvirus 2, Gallid / Q000276:immunology*; D007111:Immunity, Cellular; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis; D008213:Lymphocyte Activation / Q000276:immunology; D008380:Marek Disease / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology*; D009168:Mycobacterium phlei / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D000939:Epitopes; D007961:Leukocyte Migration-Inhibitory Factors