Effect of repeated exposure to lindane and cadmium on lindane metabolism in rats.
The effects of daily administration of cadmium and lindane for 35 days on the metabolism of lindane in rats were investigated. The results indicate that cadmium induces a significant inhibition of lindane metabolism, since the group dosed with lindane plus cadmium had a significantly higher concentration of lindane in plasma and tissues than the group dosed with lindane alone. The inhibition in the metabolic rate of lindane is associated with the cadmium-induced alterations in the disposition of essential trace elements, Zn, Cu and Fe, in the liver.
Khanna
R N
RN
Industrial Toxicology Research Centre, Lucknow, India.
Anand
M
M
Gopal
K
K
Varma
N
N
Gupta
G S
GS
Ray
P K
PK
D000818:Animals; D001921:Brain / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000378:metabolism; D004347:Drug Interactions; D001556:Hexachlorocyclohexane / Q000378:metabolism* / Q000633:toxicity; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D002104:Cadmium; D001556:Hexachlorocyclohexane; D003300:Copper; D007501:Iron; D015032:Zinc