title: Bidirectional regulatory circuit between the immune and neuroendocrine systems.
abstract: The immune system and the neuroendocrine system affect each other via molecules and receptors shared by both systems. Activation of the neuroendocrine system results in a generalized alteration in host homeostasis and immune response. The interaction appears to be a complete circuit in that products of the immune system can also modulate nervous and neuroendocrine system responses. Since different hormones/soluble mediators are produced by neuroendocrine and immune cells, the particular alteration is a function of the induction stimulus.
authors: Department of Toxicology, Hazelton Laboratories America, Inc., Vienna, Va.
authors: J
authors: J
authors: Cavagnaro
authors: R M
authors: RM
authors: Lewis
mesh_terms: D000818:Animals; D005246:Feedback; D006168:Guinea Pigs; D006706:Homeostasis; D006728:Hormones / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000503:physiopathology; D007107:Immune System / Q000502:physiology*; D007249:Inflammation; D007375:Interleukin-1 / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D009490:Neurosecretory Systems / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D013373:Substance P / Q000502:physiology
chemical_list: D006728:Hormones; D007375:Interleukin-1; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D013373:Substance P