Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
In a subchronic 90-day oral toxicity study, 5 groups (20 males, 20 females each) of F2-descendants of BIO F1D Alexander hamsters received 0, 275, 550, 1,100 and 2,200 mg/kg b.w./day doses, respectively, of calcium cyclamate in the drinking water. These doses caused no adverse health effects in any treated animal and the multifocal myocardial calcifications, detectable at a 100% incidence in the male and female control hamsters (20 males, 20 females), were not exacerbated by the sweetener. Instead, the myocardial lesions exhibited a striking negative dose-response relationship with a 0% incidence in the males and a 5% incidence in the female hamsters of the highest dose group.
Ernst
H
H
Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover.
Rittinghausen
S
S
Bellmann
B
B
Xie
Z X
ZX
Mohr
U
U
D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000473:pathology; D006224:Cricetinae; D003494:Cyclamates / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000473:pathology*; D012016:Reference Values
D003494:Cyclamates