Paired comparisons of steroid-eluting and nonsteroid endocardial pacemaker leads in dogs: electrical performance and morphologic alterations.
The effects of steroid elution from endocardial pacemaker electrodes on electrical performance and the thickness and cellularity of the reactive fibrous connective tissue formed around the stimulating electrode (peri-electrode tissue) were determined. Comparison was made with a nonsteroid electrode implanted in the same cardiac chamber (right ventricle) in each of six dogs for 6 weeks. Paired Students' t-tests showed that steroid-eluting leads had significantly (P less than .05): (1) lower voltage stimulation thresholds (as determined in sequential measurements made on the conscious animals during the experiment and on the anesthetized dogs at termination of the study); (2) less fibrous connective tissue formation around the electrode surfaces; and (3) fewer cells per unit area of peri-electrode fibrous connective tissue. There were also fewer (P less than .10) mast cells in the reactive connective tissue surrounding steroid-eluting leads. The thinner reactive connective tissue surrounding the steroid-eluting electrodes was correlated with lower voltage stimulation thresholds (r = 0.7, P less than .01). This is consistent with the hypothesis that the effect of the peri-electrode connective tissue is to increase the virtual surface area of the electrode, decreasing current density in adjacent stimulatable tissue. The relatively fewer total cells and mast cells in the peri-electrode connective tissue of the steroid-eluting electrodes suggest that the observed differences in fibrous connective tissue thickness, and therefore voltage stimulation threshold, may be related to a relatively decreased population of inflammatory cells due to the anti-inflammatory properties of the steroid.
Radovsky
A S
AS
Dept. of Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47906.
Van Vleet
J F
JF
Stokes
K B
KB
Tacker
W A
WA
D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004285:Dogs; D004526:Efficiency; D004567:Electrodes, Implanted; D004867:Equipment Design; D010138:Pacemaker, Artificial
C004180:dexamethasone 21-phosphate; D003907:Dexamethasone