[Pharmacokinetics and pharmacodynamics of the new Russian anti-arrhythmia drug allapinin].
Pharmacokinetics of allapinin tablets, used as a single dose, alone or in combination with other antiarrhythmic drugs (cordarone, mexitil, ritmilen) were assessed in 11 patients with frequent extrasystoles. Allapinin pharmacokinetic pattern was basically similar in patients in whom it was very effective and those in whom it had no effect. Combined use of the above-mentioned antiarrhythmic drugs and allapinin did not affect the latter's pharmacokinetic parameters. Allapinin pharmacokinetics can be described using a one-part model.
Abdalla
A
A
Rulin
V A
VA
Mazur
N A
NA
Sumarokov
A B
AB
Chikovani
S I
SI
D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D031841:Aconitum / Q000031:analogs & derivatives*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013607:Tablets; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D013607:Tablets; C051402:allapinin; D000157:Aconitine
Farmakokinetika i farmakodinamika novogo otechestvennogo antiaritmicheskogo preparata allapinina.