Human angiogenin, an organogenic protein.
Angiogenin is a 14 kD protein, initially isolated as a tumour-cell secreted product but subsequently found to be a normal constituent of human plasma. It is a potent inducer of blood vessel formation on the chorioallantoic membrane of the chick embryo. Chemical characterization of the protein reveals a remarkable homology to the pancreatic ribonuclease family and has led to the identification of a unique ribonucleolytic activity for angiogenin. It is a particularly potent inhibitor of in vitro protein synthesis. Treatment with placental ribonuclease inhibitor abolishes the biological and enzymatic activities of angiogenin, an effect with important mechanistic, physiological and pharmacologic implications.
Riordan
J F
JF
Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA.
Vallee
B L
BL
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000097:blood / Q000302:isolation & purification* / Q000494:pharmacology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D010926:Placental Hormones / Q000494:pharmacology; D014176:Protein Biosynthesis; D012259:Ribonuclease, Pancreatic; D012260:Ribonucleases / Q000032:analysis / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured / Q000378:metabolism
D009363:Neoplasm Proteins; D010926:Placental Hormones; C022052:placental ribonuclease inhibitor; D012260:Ribonucleases; C046366:angiogenin; D012259:Ribonuclease, Pancreatic