Effects of glucose-6-phosphate dehydrogenase deficiency upon sickle cell anaemia.
The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
al-Ali
A K
AK
Department of Biochemistry, College of Medicine and Medical Sciences, King Faisal University, Dammam, Saudi Arabia.
Ahmed
M A
MA
al-Idrissi
H
H
al-Sibai
M H
MH
al-Mutairy
A R
AR
al-Awami
M
M
D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000150:complications; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000097:blood; D012529:Saudi Arabia
D005319:Fetal Hemoglobin; D006442:Glycated Hemoglobin