title: Auditory event-related potentials in adult patients with Gilles de la Tourette's syndrome in the oddball paradigm.
abstract: In 20 Tourette patients and 20 control subjects auditory event-related potentials evoked in an oddball paradigm were studied in 2 conditions: a non-motor condition (NMC) in which subjects had to attend tones, and a motor condition (MC) in which they had to press a microswitch to deviant tones. In the NMC patients had a reduced P2 in response to the standards. The deviant-standard subtraction wave forms of the NMC showed a discernible MMN-P165-N2b-P3 complex in the controls, whereas in the patients only the P3 was well developed. In the MC patients had a reduced N1 to the standards. Both groups showed in the deviant-standard subtraction wave forms a clear MMN-P165-N2b-P3 complex, N2b being reduced in the patients. In the patients the P2 amplitude and latency to the standards and in the controls the N2b amplitude in the deviant-standard subtraction wave form were larger in the MC than in the NMC. Both groups also showed a larger P3 and a larger parietal slow positive wave in the MC than in the NMC. The results are discussed in relation to behavioural and neuropsychological disturbances found in Gilles de la Tourette's syndrome.
authors: Department of Neuropsychiatry, Psychiatric Centre Rosenburg, The Hague, The Netherlands.
authors: T C
authors: TC
authors: Van Woerkom
authors: C
authors: C
authors: Fortgens
authors: C M
authors: CM
authors: Rompel-Martens
authors: B J
authors: BJ
authors: Van de Wetering
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D009431:Neural Conduction; D011597:Psychomotor Performance; D005879:Tourette Syndrome / Q000503:physiopathology*