Vasocortin-like proteins induced by glucocorticoids in vascular tissue.
Rat and bovine aorta rings incubated with 10(-5) M dexamethasone release proteins which inhibit rat dextran oedema. These proteins seem to be related to vasocortin, derived from the peritoneal fluid of dexamethasone-treated rats, and may contribute to the control that glucocorticoids exert on vascular tonus and permeability.
Carnuccio
R
R
Department of Experimental Pharmacology, University of Naples, Italy.
Di Rosa
M
M
Iuvone
T
T
Marotta
P
P
Sautebin
L
L
D000315:Adrenalectomy; D000818:Animals; D017302:Annexins; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001202:Ascitic Fluid / Q000378:metabolism; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D003907:Dexamethasone / Q000494:pharmacology; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005938:Glucocorticoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D014176:Protein Biosynthesis; D011506:Proteins; D051381:Rats; D011919:Rats, Inbred Strains
D017302:Annexins; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D005938:Glucocorticoids; D011506:Proteins; C052038:vasocortin; D003907:Dexamethasone