title: Temporal and constitutive expression of homeobox-2 gene (Hu-2), human heat shock gene (hsp-70), and oncogenes C-sis and N-myc in early human trophoblast.
abstract: Recent studies of the genetic basis of animal development indicate that homeobox genes, protooncogenes, and some heat shock genes may play a role in early embryogenesis. To investigate the possibility that these genes function in early human embryonic development, we monitored the expression of a human homeobox gene (Hu-2), two human protooncogenes (C-sis and N-myc), and a human heat shock gene (hsp-70) in human trophoblasts at 7 to 13 weeks gestational age. All these genes were found to be expressed in the tissues analyzed. The hsp-70 gene was expressed at nearly constant levels throughout the development period surveyed, whereas N-myc, C-sis, and Hu-2 showed a coordinated pattern of regulated expression. These results are consistent with a functional role of these genes in the early course of human development.
authors: Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912.
authors: B C
authors: BC
authors: Su
authors: D
authors: D
authors: Strand
authors: P G
authors: PG
authors: McDonough
authors: J F
authors: JF
authors: McDonald
mesh_terms: D015152:Blotting, Northern; D004247:DNA; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D005865:Gestational Age; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012313:RNA; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014327:Trophoblasts / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins; D012313:RNA; D004247:DNA