Modulation of human granulopoiesis by macrophage-derived growth regulators.
The response of granulocyte progenitors (CFU-D) from patients with chronic myeloid leukaemia (CML), neutrophilic reaction (NR) and healthy subjects to macrophage-derived stimulatory and inhibitory factors was investigated in diffusion chamber culture. CFU-D from CML and NR demonstrated a normal reactivity to macrophage stimulation but were hyporesponsive to indomethacin-sensitive inhibition. It is also shown that the spleens of patients with Hodgkin's disease contain locally activated macrophages with higher production of indomethacin-sensitive growth inhibiting factor for autologous CFU-D clonal proliferation.
Hansz
J
J
Department of Haematology, Academy of Medicine, Poznań, Poland.
D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D015194:Diffusion Chambers, Culture; D006098:Granulocytes / Q000166:cytology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006689:Hodgkin Disease / Q000503:physiopathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor; D008264:Macrophages / Q000502:physiology; D009504:Neutrophils / Q000473:pathology; D013154:Spleen / Q000166:cytology / Q000503:physiopathology
D003115:Colony-Stimulating Factors; D016173:Macrophage Colony-Stimulating Factor