title: Histamine-releasing activity of mouse spleen cell culture supernatants.
abstract: Histamine releasing factor (HRF) generated in vitro by spleen cells of immunized mice activates homologous peritoneal mast cells (both normal and sensitized) for small but consistent, dose-dependent histamine and 5-hydroxytryptamine release. Both the time-course of this release and its susceptibility to the enhancing effect of D2O were similar to those observed in IgE-induced release; however, simultaneous challenge of sensitized mast cells with HRF and specific antigen or anti-IgE showed an additive effect, suggesting that mediator release by HRF and by the IgE system are independent of one another.
authors: Department of Biogenic Amines, Polish Academy of Sciences, Lódź, Poland.
authors: J
authors: J
authors: Wyczółkowska
authors: Z
authors: Z
authors: Sułowska
authors: E
authors: E
authors: Brzezińska-Błaszczyk
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D005260:Female; D006636:Histamine Release; D007114:Immunization; D008222:Lymphokines / Q000096:biosynthesis; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013154:Spleen / Q000276:immunology*; D000090324:Tumor Protein, Translationally-Controlled 1
chemical_list: D014408:Biomarkers, Tumor; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1; D012701:Serotonin