The measurement of gastric mucus using a computer image processing system.
The measurement of gastric mucus, and the effects of aspirin and some antiulcer drugs on the content or components of gastric mucus were investigated in normal rats by using a newly devised computer image processing system. The present method enabled us to separate mucus components into PAS positive mucus (PAS+), and AB positive mucus (AB+), and to measure the amount of each mucus. Aspirin induced significant decreases in both PAS+ and AB+, teprenone increased the total amount of gastric mucus (PAS+ plus AB+), secretin tended to increase AB+, and cimetidine and omeprazole caused no remarkable changes on mucus secretion. These changes in gastric mucus could be observed on both microscopic observation and with the computer image processing system. The results indicate that the computer image processing system is very useful for the measurement of gastric mucus.
Kagoshima
M
M
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Kodaira
H
H
Motoyoshi
Y
Y
Shimada
H
H
D000818:Animals; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D008297:Male; D009093:Mucus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling; D013268:Stimulation, Chemical