Structure and stability of the Boc(D-Pro-L-Pro)2OCH3 Na+ complex: a model of poly(D,L-proline), an alkali ion channel across membranes.
In order to elucidate the molecular mechanisms of alkali ions conduction of poly(D,L-proline), which shows the typical behavior of an ion channel across membranes, conformations of the tetrameric derivative Boc(D-Pro-L-Pro)2OCH3 in solution, in the presence of the Na+ ion, were investigated by CD and nmr spectroscopy. Both theoretical and experimental data indicate the formation in solution of a monomeric complex between the tetramer, in the all-trans conformation, and the cation. The results allow to confirm the channel model, previously proposed on the phenomenological behavior of poly(D,L-proline) in membranes.
De Santis
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P
Scipioni
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Palleschi
A
A
Savino
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M
D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000502:physiology*; D008954:Models, Biological; D008958:Models, Molecular; D009842:Oligopeptides; D010455:Peptides; D011487:Protein Conformation
D007473:Ion Channels; D009842:Oligopeptides; D010455:Peptides; C059754:tert-butyloxycarbonylprolyl-prolyl-prolyl-proline methyl ester; C011083:polyproline