Growth and antigenic characteristics of basal cell carcinoma in culture.
Basal cell carcinomas (BCCs) were cultured using an explant method and compared with normal cultured skin. Immunohistochemical staining revealed reduced beta 2 microglobulin uptake by BCCs in frozen section, but normal staining of the tumours in culture. In culture, fibronectin was detected on the cell surface of normal keratinocytes but not on BCCs. The above differences may explain some of the behaviour of BCCs in vivo.
Bradbeer
M
M
Monash University Department of Medicine, Melbourne, Australia.
Bourne
A J
AJ
Ayberk
H
H
Tang
S K
SK
Marks
R
R
D000951:Antigens, Neoplasm; D002280:Basal Cell Carcinoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D001613:beta 2-Microglobulin / Q000378:metabolism
D000951:Antigens, Neoplasm; D005353:Fibronectins; D001613:beta 2-Microglobulin; D007633:Keratins