title: The productive infection of alveolar macrophages by simian immunodeficiency virus.
abstract: Alveolar macrophages obtained from healthy rhesus monkeys were infected with SIV in vitro as documented by the appearance of reverse transcriptase activity in the cell-free supernatant, electronmicroscopy, and immunohistochemical methods detecting SIV-related core protein. The results demonstrate permissive infection of alveolar macrophages with SIV in vitro and define a system for studying macrophage-SIV interactions.
authors: Harvard Medical School, New England Regional Primate Research Center, Southborough, MA.
authors: D J
authors: DJ
authors: Ringler
authors: M S
authors: MS
authors: Wyand
authors: D G
authors: DG
authors: Walsh
authors: J J
authors: JJ
authors: MacKey
authors: P K
authors: PK
authors: Sehgal
authors: M D
authors: MD
authors: Daniel
authors: R C
authors: RC
authors: Desrosiers
authors: N W
authors: NW
authors: King
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002478:Cells, Cultured; D007124:Immunoenzyme Techniques; D008253:Macaca mulatta; D008264:Macrophages / Q000382:microbiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000166:cytology / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D015302:Simian Immunodeficiency Virus / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure; D014779:Virus Replication
chemical_list: D012194:RNA-Directed DNA Polymerase