Blood platelet function in patients with obliterative arteriosclerosis of the lower limbs.
The specific markers of platelet activation, e.g. platelet aggregation induced with ADP, AA and PAF as well as the levels of Beta-TG, TXB2, 6-keto-PGF1 alpha and cyclic AMP in the patients suffering from obliterative arteriosclerosis of the lower limbs were measured. It was found that these patients revealed hyperfunction of blood platelets expressed in increased sensitivity of platelets to ADP and PAF, increased levels of Beta-TG and TXB2 as well as decreased levels of 6-keto-PGF1 alpha and cyclic AMP. Obtained results support the concept that atherosclerosis consists of a wide-spread functional alteration of various types of cells.
Bodzenta-Lukaszyk
A
A
Department of Haemtology, Medical School Bialystok, Poland.
Krupiński
K
K
Dabrowski
S
S
Bielawiec
M
M
D000244:Adenosine Diphosphate / Q000502:physiology; D000328:Adult; D000368:Aged; D001095:Arachidonic Acids / Q000494:pharmacology; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation
D001095:Arachidonic Acids; D015415:Biomarkers; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate