[A correlation between the evaluation of assay results of immuno-suppressive substance (IS) in the blood and other parameters in patients with gastric cancer].
This present study has assayed the immuno-suppressive substance (IS) in the blood level at certain definite times in patients with a gastric cancer. Prior to surgery, the positivity of IS was low in Stages I and II but rose rapidly with the advance in stage. Therefore this assay has little meaning as a method for screening the cancer. Two months after operation, a loss in the IS amount occurred, due to the therapeutic treatment that had been initiated, and a state of equilibrium was reached after the third month. This IS withdrawal from the blood was delayed in comparison with other parameters. Further, a mild negative correlation was observed between the IS blood levels and the PPD intracutaneous reaction, which was determined in parallel, while a moderately positive correlation was found between the IS blood levels and the levels of the tissue polypeptide antigen and the alpha 2-globulin in the blood. The determination of the IS blood levels at specific times has been deemed useful and should be done in combination with the evaluation of the other parameters, which have different mechanisms of formation, so as to ascertain the general condition of the cancer patient.
Tanaka
T
T
Dept. of Surgery, Fukui Red Cross Hospital.
Harada
T
T
Mise
K
K
Furutani
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000510:Alpha-Globulins / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010455:Peptides / Q000032:analysis; D013274:Stomach Neoplasms / Q000097:blood* / Q000276:immunology / Q000601:surgery; D019396:Tissue Polypeptide Antigen; D014374:Tuberculin Test
D000510:Alpha-Globulins; D006023:Glycoproteins; D009363:Neoplasm Proteins; D010455:Peptides; D019396:Tissue Polypeptide Antigen; C038588:serum immunosuppressive factor, human