Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion.
The effects of cholecystokinin receptor antagonist, dipentyl-3,4-dichloroproglumide (DDP), on stimulated pancreatic and gastric secretion were studied in the rat. DDP dose-dependently inhibited cholecystokinin-stimulated amylase release from dispersed acinar cells. In vivo, DDP inhibited cholecystokinin octapeptide-stimulated amylase and protein secretion. DDP also inhibited pentagastrin-stimulated gastric acid secretion in vivo. Meal-stimulated acid output was decreased by 34% (DDP 400 micrograms/kg/hr) but responsiveness to histamine or parachlorophenyl-gamma-aminobutyric acid was unchanged.
Mulholland
M W
MW
Department of Surgery, University of Michigan, Ann Arbor 49109.
Debas
H T
HT
D000681:Amylases / Q000378:metabolism; D000818:Animals; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000502:physiology*; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology
D011949:Receptors, Cholecystokinin; D000681:Amylases; D010418:Pentagastrin; D011377:Proglumide; C048181:lorglumide; D012844:Sincalide