Preoperative adjuvant chemotherapy for advanced head and neck cancer: a surgical evaluation.
This presentation consists of two parts: 1) a brief account of the results of treating 94 patients with stage III (n = 24) and stage IV (n = 70) advanced head and neck cancer, primarily with two courses of preoperative adjuvant chemotherapy; and 2) an evaluation of 42 of the 94 patients consecutively treated by surgery by the senior author. It is our conclusion that preoperative chemotherapy using cisplatin, vincristine, and bleomycin can improve the compromised airway and deglutition without producing deleterious effects relative to surgical complications. Moreover, overall survival is promising and justifies continued study using organized protocols.
Loré
J M
JM
Department of Otolaryngology, School of Medicine, State University of NY, Buffalo 14214.
Bonilla
J A
JA
Spaulding
M
M
Lee
K Y
KY
Kaufman
S
S
Sundquist
N
N
Smeeding
D
D
D000402:Airway Obstruction / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000601:surgery / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004937:Esophageal Fistula / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D014750:Vincristine; D002945:Cisplatin