Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens.
In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.
Steinhoff
U
U
Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
Kaufmann
S H
SH
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis* / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009166:Mycobacterium leprae / Q000276:immunology*; D010641:Phenotype; D012583:Schwann Cells / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000145:classification* / Q000276:immunology
D000942:Antigens, Bacterial; D000945:Antigens, Differentiation, T-Lymphocyte; D000939:Epitopes