[Furosemide-sensitive cation transport in frog skeletal muscle fibers].
Furosemide-inhibitable components in unidirectional cation fluxes have been identified in frog skeletal muscle. In sodium loaded muscles, placed in sodium-free rubidium lithium media, furosemide (1 mM) inhibits partially rubidium and lithium influxes as well as potassium and sodium outfluxes. The furosemide-inhibitable components were found to depend on the presence of ouabain. They were greatly diminished in sodium-free magnesium media and were present in chloride-free nitrate containing media. The dependence of furosemide-inhibitable sodium efflux on internal sodium content was also described.
Vinogradova
T A
TA
Marakhova
I I
II
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003864:Depression, Chemical; D005665:Furosemide / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008094:Lithium / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D011896:Rana temporaria; D012413:Rubidium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects / Q000378:metabolism
D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels; D010042:Ouabain; D005665:Furosemide; D008094:Lithium; D012964:Sodium; D012413:Rubidium; D011188:Potassium
Furosemidchuvstvitel'nyĭ transport kationov v skeletnykh myshechnykh voloknakh liagushki.