title: High amount of dietary carbohydrate does not cause an adaptational increase of stimulated human pancreatic amylase secretion.
abstract: In order to investigate whether the human pancreas is capable of adapting to a diet with high-carbohydrate, low-fat, and normal protein content, 10 healthy volunteers were given a defined elemental diet (60% of calories as carbohydrates, 22% as fat, and 18% as protein) for 7 d. For the next 7 d they received an elemental diet with a further increased carbohydrate content (76% of calories) and a decreased fat content (10% of calories). A complete secretin-pancreozymin test was carried out at the end of the first wk and at d 14. The results show that an increase in dietary carbohydrate does not provoke an adaptational response of stimulated secretion rates of amylase, trypsin, and chymotrypsin in humans, as expected from animal experiments.
authors: Medizinische Klinik, Klinikum Steglitz der FU Berlin, FRG.
authors: R M
authors: RM
authors: Liehr
authors: M E
authors: ME
authors: Herrmann
authors: C
authors: C
authors: Emde
authors: R
authors: R
authors: Hopert
authors: E O
authors: EO
authors: Riecken
mesh_terms: D000064:Acclimatization; D000328:Adult; D000681:Amylases / Q000378:metabolism*; D001639:Bicarbonates / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002918:Chymotrypsin / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology*; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D011228:Prealbumin / Q000032:analysis; D012016:Reference Values; D014357:Trypsin / Q000378:metabolism; D014508:Urea / Q000097:blood
chemical_list: D001639:Bicarbonates; D004040:Dietary Carbohydrates; D011228:Prealbumin; D014508:Urea; D002784:Cholesterol; D000681:Amylases; D002918:Chymotrypsin; D014357:Trypsin