[The morphology of chemically induced kidney tumors of the rat as a model for the typing of human kidney tumors].
1. 109 renal cell carcinomas were produced in 92 Wistar rats by a single dose of 80 mg/kg diethylnitrosamine 4, 16, 24 h after partial liver resection. These tumors showed a wide variety of morphological appearances, comparable with different types of human renal cell carcinomas, as proposed by THOENES et al. in a new cytomorphological classification. However, there were striking differences as to the incidence of the individual tumors types. Whereas clear cell tumor prevailed in human they were very rare in the animal experiment. 2. 54 renal cell carcinomas were produced in 105 rats by a single dose of 30 mg/kg dimethylnitrosamine after a low-protein diet of 5 days. Also in this experiment a variety of different tumor types resulted. Already in early "tubular lesions" a strikingly elevated thymidine labelling was found, in contrast to the surrounding regular tubular epithelial cells. Moreover, topographical relations of various tumor cell types to different segments of the nephron became evident. Besides a fair number of basophilic tumors with transition into proximal tubular epithelial cells, a large number of tumors showing abundant, typically vacuolated cytoplasm became evident. These tumor cells showed in general the highest labelling index with thymidine. They apparently are related to the distal nephron and possibly constitute neoplasms of the collecting ducts, compatible with otherwise rare ductus Bellini carcinomas. Concluding, the heterogeneity concerning tumor cell types and labelling indices has to be emphasized, whereby the latter also, appear to be dependent on the vascular blood supply.
Meister
P
P
Brummer
C
C
Rabes
H
H
D000818:Animals; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000145:classification / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats
Zur Morphologie chemisch induzierter Nierentumoren der Ratte als Modell für die Typisierung von menschlichen Nierentumoren.