[Acute phase protein (alpha 1 AT) as a tumor marker in patients with ovarian cancer (OC)].
Serum alpha 1 AT was measured in 30 healthy women, 30 pregnant women, in 97 patients with various benign gynecologic diseases, and 38 patients with OC. The positive ratio (cut off level: 317 mg/dl) in OC patients was 78.9% (30/38), 11.3% (11/97) in patients with a benign gynecologic disease, 90% (27/30) in pregnant women, and 0% (0/30) in healthy women. Histologically 92.3% of the patients (12/13) with a serous cystadenocarcinoma, 50% (4/8) with an endometrioid carcinoma, and 77.8% (7/9) with a mucinous cystadenocarcinoma were positive, but only 5.9% of the patients with a chocolate cyst were positive. Thus it was found that alpha 1 AT is a useful tumor marker in diagnosing OC.
Kawai
M
M
Dept. of Obstet. & Gyne., Toyohashi City Hospital.
Iida
N
N
Inagaki
S
S
Yamashita
H
H
Imaizumi
H
H
Kakihara
M
M
Arii
Y
Y
D000209:Acute-Phase Proteins / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D003536:Cystadenocarcinoma / Q000175:diagnosis; D003537:Cystadenoma / Q000175:diagnosis; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000209:Acute-Phase Proteins; D014408:Biomarkers, Tumor; D000515:alpha 1-Antitrypsin