Exposure of human cells to low-frequency electromagnetic fields results in quantitative changes in transcripts.
The exposure of human cultured cells to electromagnetic signals with extremely low repetition rates resulted in an increased level of selected RNA transcripts. RNA with homology to beta-actin, histone H2B, and v-myc DNA was monitored by dot blot hybridization following 20 min exposures of HL60 cells to five different electromagnetic signals. The experiments used three asymmetric electromagnetic signals with different repetition rates, and two symmetric sinusoidal signals, delivered at 60 and 72 Hz. The degree of increase in homologous transcripts was dependent on the signal characteristics.
Goodman
R
R
Department of Pathology, Columbia University Health-Sciences, New York, NY 10032.
Wei
L X
LX
Xu
J C
JC
Henderson
A
A
D000199:Actins / Q000235:genetics; D015152:Blotting, Northern; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D006657:Histones / Q000235:genetics; D006801:Humans; D009857:Oncogenes; D012313:RNA / Q000235:genetics* / Q000528:radiation effects; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic / Q000528:radiation effects*
D000199:Actins; D006657:Histones; D012313:RNA; D004247:DNA