Inhibition of human immunodeficiency virus-associated reverse transcriptase by 14-O-acyladriamycins.
It was reported that doxorubicin inhibited virus reverse transcriptase. We have synthesized various new 14-O-acyladriamycins. The derivatives having a 17-O-benzoyl group with hydrophobic aliphatic side chains showed stronger inhibitory activity on human immunodeficiency virus reverse transcriptase and lower cytotoxicity on mouse leukemia cells.
Ajito
K
K
Institute of Microbial Chemistry, Tokyo, Japan.
Atsumi
S
S
Ikeda
D
D
Kondo
S
S
Takeuchi
T
T
Umezawa
K
K
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D006678:HIV / Q000201:enzymology*; D006801:Humans; D007941:Leukemia P388; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors; D014407:Tumor Cells, Cultured
D018894:Reverse Transcriptase Inhibitors; D004317:Doxorubicin