[Effect of low-molecular interferon inducers in experimental hepatitis in mice].
Among low molecular interferon inducers preparations were selected which were capable of inducing interferon (IFN) synthesis after oral administration and advantageous for further clinical use. The dynamics of interferon production was studied after oral administration of three national low molecular interferon inducers. The selected preparations: a synthetic inducer, amiksin, and 2 natural compounds (gossypol derivatives), kagocel-1 and PXL-6, stimulated high levels of interferon production (from 10,000 to 20,000 IU/ml) in the intestinal tract of the animals 4 hours after induction and protected the animals from hepatitis virus of mice (the Meshcherin strain) after oral administration 24 hours before infection (35-55%). Amiksin and PXL-6 produced significant protection (p less than 0.01 or 0.001)--40 or 50%, respectively, when administered 4 hours before virus infection.
Tazulakhova
E B
EB
Saĭitkulov
A M
AM
Barinskiĭ
I F
IF
Ershov
F I
FI
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006072:Gossypol / Q000031:analogs & derivatives / Q000627:therapeutic use; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy*; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000032:analysis; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D006517:Murine hepatitis virus; D009930:Organic Chemicals; D013994:Tilorone / Q000031:analogs & derivatives / Q000627:therapeutic use; D013997:Time Factors
D007369:Interferon Inducers; D009930:Organic Chemicals; C056991:cagocel-1; C055879:PXL 6; D007372:Interferons; D006072:Gossypol; D013994:Tilorone
Effekt nizkomolekuliarnykh induktorov interferona pri éksperimental'nom gepatite mysheĭ.