[The nature of the factors in immune lymph nodes that stimulate humoral and cellular immune reactions].
In the early period after antigen action, cells of the lymph node draining area of antigen injection produce a factor, which after its administration to intact mice, promotes intensified migration of myelopeptide producers in the bone marrow and increases bone marrow suppressor activity. Factor administration produced 2-3-fold increase in macrophage, peritoneal and lymph node count as compared with control, and 2-4-fold increase in humoral and cellular immune response. The factor consists of three easily identifiable components: Ig, MHC class II determinants and antigen determinants, that form unique complex similar to, or identical with the complexes detected in vivo within 3-6 hours after immunization in serum by other authors.
Novikov
V I
VI
Vlasov
A A
AA
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000939:Epitopes / Q000032:analysis / Q000302:isolation & purification; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000302:isolation & purification; D007111:Immunity, Cellular; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis / Q000302:isolation & purification; D008198:Lymph Nodes / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008970:Molecular Weight; D009368:Neoplasm Transplantation
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007136:Immunoglobulins
Priroda fakotorv immunnykh limfaticheskikh uzlov, stimuliruiushchikh gumoral'nye i kletochnye immunnye reaktsii.