The effects of oxygen free radicals on wound healing.
We have examined the effects of oxygen free radicals, generated by xenobiotics administration, ischaemia-reperfusion or sepsis, on the healing of skin or intestinal wounds in rats. We found that 5 days after operation there was a significant decrease in the wound breaking strength in rats treated with phenazine methosulfate, zymosan, ischaemia-reperfusion or retroperitoneal infection. These changes were specifically prevented by administration of superoxide-dismutase (SOD), aprotinin and (in some models) allopurinol. On the contrary, none of these measures was effective when a local trauma caused the decrease in breaking strength. Our results suggest that oxygen free radicals mediate the inhibition of wound healing following ischaemia-reperfusion and sepsis.
Foschi
D
D
Department of Surgery, Institute of Biomedical Sciences, L. Sacco, University of Milan, Italy.
Trabucchi
E
E
Musazzi
M
M
Castoldi
L
L
Di Mattia
D
D
Radaelli
E
E
Marazzi
M
M
Franzini
P
P
Berlusconi
A
A
D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D005260:Female; D005609:Free Radicals; D008773:Methylphenazonium Methosulfate / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*; D015262:Xenobiotics / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D005609:Free Radicals; D015262:Xenobiotics; D008773:Methylphenazonium Methosulfate; D000493:Allopurinol; D015054:Zymosan; D007611:Aprotinin; D013482:Superoxide Dismutase; D010100:Oxygen