The influence of anesthetics and vasoconstrictors on nasal mucociliary transport.
Nasal mucociliary transport time is studied in 38 healthy individuals using the charcoal dust technique, following topical application of a lidocaine solution in 10 cases, tetracaine in 11, and oxymetazoline in 17. The results show that lidocaine does not alter the transit time, whereas tetracaine increases it significantly; in turn, oxymetazoline progressively increases transit time, although this slowing is fully reversible 30 minutes after application.
Armengot
M
M
Valencia University Clinic Hospital, Spain.
Basterra
J
J
Garcia-Bartual
E
E
D000328:Adult; D000777:Anesthetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D014663:Nasal Decongestants / Q000494:pharmacology*; D010109:Oxymetazoline / Q000494:pharmacology; D013748:Tetracaine / Q000494:pharmacology
D000777:Anesthetics; D014663:Nasal Decongestants; D013748:Tetracaine; D010109:Oxymetazoline; D008012:Lidocaine