title: Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze.
abstract: The effect of intraventricular administration of the neuropeptide galanin on acquisition and retrieval in a modified Morris swim maze was studied in rats. Galanin induced a significant deficit in the acquisition of the task while no effects on the retrieval were observed. No deficits were seen 24 h after the last treatment. Galanin did not increase the number of failures to reach the platform. It is suggested that endogenous galanin modulates learning possibly via the galanin-containing cholinergic neurons in the septum-basal forebrain area projecting to the hippocampus and cortex.
authors: Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
authors: E
authors: E
authors: Sundström
authors: T
authors: T
authors: Archer
authors: T
authors: T
authors: Melander
authors: T
authors: T
authors: Hökfelt
mesh_terms: D000818:Animals; D019004:Galanin; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior / Q000187:drug effects*; D013550:Swimming
chemical_list: D010455:Peptides; D019004:Galanin