Lindane mediated induction of cytochrome P-450 mRNA in rat liver: studies with a nonradioactive cDNA probe.
Effect of lindane on the induction of cytochrome P-450 mRNA in rat liver was studied using a biotinylated cDNA probe. Exposure to lindane resulted in an increase in the levels of P-450 mRNA. The observed increase in mRNA was maximal (5-6-fold) after 18 hr of lindane treatment and lesser (50%) than mediated by phenobarbital for the same duration.
Dwivedi
P P
PP
Kumar
A
A
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D015342:DNA Probes; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D015342:DNA Probes; D012333:RNA, Messenger; D001556:Hexachlorocyclohexane; D003577:Cytochrome P-450 Enzyme System