title: Closed loop control of rate adaptive pacing: clinical assessment of a system analyzing the ventricular depolarization gradient.
abstract: Closed loop control of rate adaptive pacing has theoretical advantages over current rate responsive pacemakers. The first available system (which senses the ventricular depolarization gradient) has been evaluated in ten patients. The pacing response to a variety of exercise and nonexercise stimuli was assessed. Response to isotonic exercise was prompt and proportional to the exertion involved while isometric exercise and mental stress produced obvious but more gradual increases in pacing rate. In seven patients, comparison between the intrinsic P wave and pacing rate showed a high correlation during exercise (r = 0.91) and mental activity (r = 0.87). Postural changes induced a paradoxical response. Closed loop rate responsive pacing based upon analysis of the ventricular depolarization gradient produces a fast and appropriate rate response to most physiological stimuli.
authors: Department of Cardiological Sciences, St. Georges Hospital Medical School, London, United Kingdom.
authors: V
authors: V
authors: Paul
authors: C
authors: C
authors: Garratt
authors: D E
authors: DE
authors: Ward
authors: A J
authors: AJ
authors: Camm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005069:Evaluation Studies as Topic; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011187:Posture