Mucosal antibody response to vaginal infection with herpes simplex virus in pre-vaccinated guinea-pigs.
The mucosal antibody response, in female guinea-pigs vaccinated with the Skinner herpes simplex virus vaccine, has been investigated. The HSV-specific secretory IgA response was assessed using the cross-reactivity of an antiserum raised against human secretory component. Animals vaccinated subcutaneously at a distant site were shown to respond to subsequent infection with HSV by the production of HSV-specific vaginal IgG and secretory IgA. No vaginal HSV-specific antibodies were found in infected, non-vaccinated animals.
McBride
B W
BW
Porton Products Ltd, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK.
Ridgeway
P
P
Phillpotts
R
R
Newell
D G
DG
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007115:Immunization Schedule; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D009092:Mucous Membrane / Q000276:immunology; D011817:Rabbits; D012635:Secretory Component / Q000276:immunology; D014623:Vaginal Diseases / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage*
D000914:Antibodies, Viral; D000939:Epitopes; D007106:Immune Sera; D007071:Immunoglobulin A, Secretory; D012635:Secretory Component; D014765:Viral Vaccines