Dextran protection of erythrocytes from low-pH-induced hemolysis.
Low-pH-induced hemolysis of erythrocytes is inhibited by dextrans. The protective effect was observed with dextrans larger than 40 kDa. Electron microscopy showed dextrans of 150 kDa in a tight association with the erythrocyte membrane. These results indicate that dextrans stop the low-pH-induced hemolysis by interacting with the acid-induced defects in the erythrocyte membrane [(1989) Biochim. Biophys. Acta, in press].
Cudd
A
A
Biophor Corporation, Texas A & M University Research Park, College Station 77840.
Arvinte
T
T
Schulz
B
B
Nicolau
C
C
D003911:Dextrans / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000648:ultrastructure; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration
D003911:Dextrans