Prognostic significance of cystic intracranial lesions in neonates.
Thirty-five infants with cystic parenchymal lesions detected by ultrasonography during the neonatal period were evaluated via periodic neurologic and developmental assessments. Long-term neurologic status (abnormal, normal, and isolated motor deficit) was assigned at 2 years of age. Abnormal neurologic status was strongly associated with bilateral cystic lesions as well as hydrocephalus during the neonatal period. Microcephaly at 6-8 months of age also correlated with abnormal status at 2 years of age. The neurologic exam at discharge and at 6-8 months of age added further negative predictive value for the infants with isolated motor delays. A literature review was conducted to determine the incidence of motor and mental delays in a large series of infants with cystic intracranial lesions.
Hansen
N B
NB
Department of Pediatrics, Children's Hospital, Ohio State University, Columbus 43205.
Kopechek
J
J
Miller
R R
RR
Menke
J A
JA
Cordero
L
L
D001927:Brain Diseases / Q000175:diagnosis / Q000523:psychology*; D002658:Developmental Disabilities / Q000209:etiology; D007839:Functional Laterality; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D007231:Infant, Newborn; D007234:Infant, Premature; D009048:Motor Skills / Q000502:physiology; D011379:Prognosis; D012307:Risk Factors; D014463:Ultrasonography