A monoclonal antibody recognizing an iscosapeptide sequence in the heavy chain of human factor XII inhibits surface-catalyzed activation.
A monoclonal antibody (mAb B7C9) to human factor XII was produced which blocked the surface mediated coagulant activity of factor XII but not the amidolysis of H-D-ProPheArg-pNA. The mAb epitope was localized to a 20 amino acid sequence of 2.5 kDa in the heavy chain of factor XII.
Pixley
R A
RA
Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Colman
R W
RW
D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000276:immunology; D005174:Factor XII / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D007610:Kallikreins / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000939:Epitopes; D005174:Factor XII; D007610:Kallikreins