[Effect of adeturon on postradiation macromolecular synthesis in the peripheral blood leukocytes of gamma ray-irradiated rats].
DNA, RNA and protein syntheses were studied in peripheral blood leucocytes of irradiated (1-7 Gy) rats. Adeturon was shown to produce a pronounced protective effect on DNA synthesis progressively inhibited by the doses applied. The protective effect of the agent was not manifest with the slightly increased synthesis of RNA. There was a trend toward normalization of the increased protein synthesis.
Marinova
Ts
Ts
Pantev
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T
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D046911:Macromolecular Substances; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001798:Blood Proteins; D046911:Macromolecular Substances; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012313:RNA; C012704:Adeturon; D000255:Adenosine Triphosphate; D004247:DNA
Vliianie adeturona na postradiatsionnyĭ sintez makromolekul v leĭkotsitakh perifericheskoĭ krovi obluchennykh gamma-luchami krys.