Inhibition of aspartic proteinases by alpha 2-macroglobulin.
The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.
Thomas
D J
DJ
Department of Biochemistry, University of Wales College of Cardiff, U.K.
Richards
A D
AD
Kay
J
J
D002402:Cathepsin D / Q000037:antagonists & inhibitors*; D020059:Cathepsin E; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D012085:Chymosin / Q000037:antagonists & inhibitors*; D006863:Hydrogen-Ion Concentration; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D000511:alpha-Macroglobulins; D002403:Cathepsins; D020059:Cathepsin E; D012085:Chymosin; D002402:Cathepsin D