Functional expression of the amplification reaction between serotonin and epinephrine on platelets.
Human platelet reactions are enhanced when a combination of serotonin and epinephrine is used as a stimulus. The amplification of the response operates through S2-serotonergic and alpha 2-adrenergic receptor subtypes. The first wave of platelet aggregation, which is independent of platelet release products, is enhanced while the latency period for the occurrence of release reaction and prostaglandin biosynthesis is shortened. Synergism between serotonin and epinephrine on the platelet occurs at low concentration of agonists and may contribute to the formation of an arterial thrombus in vivo.
De Clerck
F
F
Life Sciences Department, Janssen Research Foundation, Beerse, Belgium.
Xhonneux
B
B
de Chaffoy de Courcelles
D
D
D000255:Adenosine Triphosphate / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D004357:Drug Synergism; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D013929:Thromboxane B2 / Q000096:biosynthesis
D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D012701:Serotonin; D013929:Thromboxane B2; D000255:Adenosine Triphosphate; D004837:Epinephrine