Macromolecular prodrugs. IX. The release kinetics of metronidazole from various dextran dicarboxylic acid hemiester conjugates in aqueous buffer, human plasma and in pig liver homogenate.
Larsen
C
C
Kurtzhals
P
P
Johansen
M
M
D000818:Animals; D003911:Dextrans; D003998:Dicarboxylic Acids; D005977:Glutarates; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008298:Maleates; D008795:Metronidazole / Q000493:pharmacokinetics*; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D013386:Succinates; D013552:Swine
D003911:Dextrans; D003998:Dicarboxylic Acids; D005977:Glutarates; D008298:Maleates; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D013386:Succinates; D008795:Metronidazole