title: Clear cell metaplasia of the breast: a lesion showing eccrine differentiation.
abstract: Clear cell metaplasia of the human breast is known to be a benign metaplastic change which has no pre-malignant connotation. Despite its proposed relationship to focal lactational change and to lactating breast, morphological and immunocytochemical features failed to demonstrate a clear relationship between these. Mucin secretion showed a characteristic pattern of granularity, and endocrine differentiation was not present. The mucin and immunocytochemical features suggest a relationship with eccrine sweat glands and a better name would perhaps be 'eccrine metaplasia' to underline the special relationship breast metaplasias have to sweat gland epithelium.
authors: Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK.
authors: M
authors: M
authors: Viña
authors: C A
authors: CA
authors: Wells
mesh_terms: D000423:Alcian Blue / Q000032:analysis; D001053:Apolipoproteins; D053399:Apolipoproteins D; D001940:Breast / Q000473:pathology*; D002352:Carrier Proteins; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006023:Glycoproteins; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007768:Lactalbumin / Q000032:analysis; D007774:Lactation; D026901:Membrane Transport Proteins; D008679:Metaplasia / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D011247:Pregnancy; D009418:S100 Proteins; D013545:Sweat Glands / Q000473:pathology*
chemical_list: C024328:APOD protein, human; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins; D009418:S100 Proteins; D007633:Keratins; D007768:Lactalbumin; D000423:Alcian Blue