title: Electrophysiological expression of endothelin and angiotensin receptors in Xenopus oocytes injected with rat heart mRNA.
abstract: Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca2+-activated chloride currents in a dose-dependent manner. In addition, no direct modulation of expressed or native cardiac Ca channels was observed.
authors: Centre de Recherche de Biochimie Macromoléculaire, UPR 8402 CNRS, U249 INSERM, Montpellier, France.
authors: P
authors: P
authors: Lory
authors: S
authors: S
authors: Richard
authors: F A
authors: FA
authors: Rassendren
authors: F
authors: F
authors: Tiaho
authors: J
authors: J
authors: Nargeot
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D018118:Chloride Channels; D002712:Chlorides / Q000502:physiology*; D004553:Electric Conductivity; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D015870:Gene Expression; D006352:Heart Ventricles / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008565:Membrane Proteins / Q000502:physiology*; D008845:Microinjections; D009206:Myocardium / Q000378:metabolism*; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000502:physiology; D017466:Receptors, Endothelin; D016276:Ventricular Function; D014981:Xenopus
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D016232:Endothelins; D007473:Ion Channels; D008565:Membrane Proteins; D010455:Peptides; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; D000804:Angiotensin II