title: [Protein composition of blood serum and the products of nitrogen metabolism in humans during long-term hypokinesia].
abstract: Examination of 9 healthy young men exposed to antiorthostatic hypokinesia (-5 degrees) for 370 days revealed enhanced catabolic processes in the muscular tissue. This manifested as increases of creatinine in blood and urine as well as of the creatinine coefficient. The use of countermeasures prior to experimental day 170 helped to maintain the concentration of final nitrogen metabolites at the baseline level. The serum concentrations of total protein and protein fractions remained within the normal limits and varied in a phasic manner. We observed a decrease of the concentration of alpha 2-globulins, which indicates inhibition of the synthetic activity of the liver, and an increase of that of beta-globulins, which suggests an adverse effect of head-down tilt on lipid metabolism.
authors: L B
authors: LB
authors: Zaĭtseva
authors: O N
authors: ON
authors: Larina
authors: I A
authors: IA
authors: Popova
mesh_terms: D000328:Adult; D000510:Alpha-Globulins / Q000172:deficiency; D001798:Blood Proteins / Q000032:analysis*; D003404:Creatinine / Q000378:metabolism*; D006801:Humans; D007019:Hypoproteinemia / Q000209:etiology; D007103:Immobilization / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D013997:Time Factors; D014508:Urea / Q000378:metabolism*
chemical_list: D000510:Alpha-Globulins; D001798:Blood Proteins; D014508:Urea; D003404:Creatinine
vernacular_title: Belkovyĭ sostav syvorotki krovi i produkty azotistogo metabolizma u cheloveka v usloviiakh dlite'lnoĭ gipokinezii.