[Medical treatment of inoperable malignant glioma. Non-superselective intra-arterial chemotherapy with HECNU followed by conventional radiotherapy].
Forty-six cases of non-surgical malignant glioma were treated by several repeated infusion of non-superselective intra-arterial chemotherapy using HECNU, followed by conventional radiotherapy. Chemotherapy was well tolerated immediately. Good responses rate was 46% for the whole group, but was higher in anaplastic astrocytomas (71%) than in glioblastomas (43%). The median survival for responders was 17 months, and clinical improvement was observed in a large majority of them. Later, neurological or ophthalmological ipsilateral complications of varying severity were observed in 8.7% and 15% of the cases respectively. Despite these complications the treatment was generally well tolerated and gave in responders a longer survival with better comfort.
Chiras
J
J
Service de Neuroradiologie Charcot, La Salpêtrière, Paris.
Fauchon
F
F
Poisson
M
M
Debussche
C
C
Chauveinc
L
L
Pereon
Y
Y
Guérin
R A
RA
Bories
J
J
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010166:Palliative Care
D009153:Mutagens; D009607:Nitrosourea Compounds; C013876:elmustine
Traitement médical des gliomes malins inopérables. Chimiothérapie intra-artérielle non hypersélective par HECNU suivie de radiothérapie conventionnelle.