Efficacy of a fibrin sealant on healing of extraction wounds.
In 61 patients, bilateral lower impacted third molars were removed. In 30 patients, a fibrin sealant was placed in the alveolus on one side immediately following the operation, while the other side functioned as control. In 31 patients, penicillin was added to the fibrin sealant, and the combination was placed in the alveolus on one side, the other side being the control. No difference with regard to bleeding, pain and swelling during the first postoperative week could be found. There was no difference between the sides regarding the incidence of postoperative infection and the healing of the alveoli after a 1-month control period.
Møller
J F
JF
Department of Oral and Maxillofacial Surgery, Royal Dental College, Aarhus, Denmark.
Petersen
J K
JK
D000287:Administration, Topical; D000328:Adult; D000539:Alveolar Process / Q000033:anatomy & histology / Q000187:drug effects*; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery; D010149:Postoperative Pain / Q000517:prevention & control; D010406:Penicillins / Q000627:therapeutic use; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D010406:Penicillins; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin