Study of T-cell antigen receptor gene rearrangement: a useful tool for early diagnosis of mycosis fungoides.
A 50-year-old man was admitted to the hospital with a diagnosis of eczema. Using study of T-cell receptor gene rearrangement on skin biopsies, a diagnosis of mycosis fungoides was made, then confirmed by evolution. This observation provides the opportunity to discuss the usefulness of molecular biology for the early diagnosis of mycosis fungoides.
Bignon
Y J
YJ
Molecular Oncology Laboratory, Clermont-Ferrand, France.
Roger
H
H
Souteyrand
P
P
Fonck
Y
Y
D'incan
M
M
Bernard
D
D
Chassagne
J
J
Dastugue
B
B
Plagne
R
R
D001706:Biopsy; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004485:Eczema / Q000175:diagnosis; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000235:genetics; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics; D013194:Staining and Labeling