The influence of modified polymeric adsorbents on blood morphologic elements and clotting factors.
The changes occurring in human blood after contact with hydrophobic sorbent Vinylsorb S and with ionosorbents Vinylsorb SS were studied. The investigations were carried out using static method at room temperature. The time of contact was 2 h. It was found that the effect of all sorbents upon the morphological elements of blood was small, only platelets were sorbed to a significant extent. The effect of sorbents upon the clotting proteins was also small and plasma hemostasis should not be affected. The sorbents containing sulphonic groups significantly activate kallikreinogenesis and may intensify shock symptoms.
Kotschy
M
M
Department of Pathophysiology Medical School, Bydgoszcz, Poland.
Trochimczuk
A
A
Kolarz
B N
BN
D000327:Adsorption; D001772:Blood Cell Count / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001793:Blood Preservation; D004906:Erythrocyte Count / Q000187:drug effects; D006801:Humans; D007610:Kallikreins / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects; D046911:Macromolecular Substances; D010976:Platelet Count / Q000187:drug effects; D011137:Polystyrenes / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology*
D001779:Blood Coagulation Factors; D046911:Macromolecular Substances; D011137:Polystyrenes; D011145:Polyvinyls; C051242:polymer 3520; D007610:Kallikreins