A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.
Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
Furukawa
K S
KS
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Furukawa
K
K
Real
F X
FX
Old
L J
LJ
Lloyd
K O
KO
D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000032:analysis / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D000939:Epitopes; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000032:analysis / Q000276:immunology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010449:Peptide Mapping; D011233:Precipitin Tests
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000939:Epitopes; D008562:Membrane Glycoproteins