title: Cross-reacting bacterial determinants in ankylosing spondylitis.
abstract: The importance of the association between the human histocompatibility antigen human leukocyte antigen-B27 and ankylosing spondylitis is undisputed, but its biologic significance remains unresolved. We have demonstrated specific cross reactivity between a range of enteric bacteria and a specific determinant found only on the surfaces of cells from human leukocyte antigen-B27-positive persons with ankylosing spondylitis. We have proposed that the genetic element coding for this cross-reactive determinant is mobile and that its acquisition by B27-positive cells in vivo represents an important step in the eventual development of ankylosing spondylitis.
authors: New South Wales Red Cross Blood Transfusion Service, Sydney, Australia.
authors: J S
authors: JS
authors: Sullivan
authors: J K
authors: JK
authors: Prendergast
authors: A F
authors: AF
authors: Geczy
authors: J P
authors: JP
authors: Edmonds
authors: L E
authors: LE
authors: McGuigan
authors: C M
authors: CM
authors: Edwards
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology* / Q000502:physiology; D002462:Cell Membrane / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology; D015796:HLA-B27 Antigen; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D000939:Epitopes; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C051103:Klebsiella modifying factor