[Inhibition of RNA synthesis in animal cells by sodium selenite].
The effect of selenium-containing compounds on RNA synthesis in rat liver cells was studied in vivo. All the selenium derivatives under study inhibited the rRNA synthesis in liver cells. The most potent inhibiting effect was exerted by sodium selenite. It was shown that in a cell-free system of RNA biosynthesis sodium selenite selectively inhibited the activity of RNA-polymerase I in isolated nuclei and purified enzyme preparations of normal and tumour cells. A feasible mechanism of inhibition of the RNA-polymerase I activity by selenium and a hypothesis on the anticarcinogenic effect of selenium are postulated.
Abdullaev
F I
FI
Allakhverdiev
I A
IA
Mamedova
G R
GR
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology; D003864:Depression, Chemical; D007939:Leukemia L1210 / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis* / Q000187:drug effects; D012318:RNA Polymerase I / Q000037:antagonists & inhibitors; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D012335:RNA, Ribosomal / Q000096:biosynthesis / Q000187:drug effects; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D018038:Sodium Selenite
D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D012313:RNA; D012318:RNA Polymerase I; D012643:Selenium; D018038:Sodium Selenite
Ingibirovanie sinteza RNK v kletkakh zhivotnykh selenitom natriia.