Binding of anti-EMA, AGF 4:48 and the lectin UEA-1 to human ovarian carcinomas: histological and clinical correlations.
The staining reactions of the monoclonal antibodies anti-EMA, AGF 4:48 and the lectin UEA-1 from Ulex europaeus were investigated in formalin-fixed, paraffin-embedded sections of 36 primary ovarian carcinomas. The staining patterns were graded and related to tumour type, differentiation, FIGO stage and patient survival. Both antibodies and UEA-1 showed variations in their staining between and within tumours. The staining of mucinous tumours using anti-EMA was significantly less than in non-mucinous tumours. No other significant associations were found between staining grade and the different variables under study. The variations in staining were not demonstrated to have any prognostic significance.
Bradgate
M G
MG
Department of Histology, Birmingham Maternity Hospital.
Redman
C W
CW
Rollason
T P
TP
Williams
A
A
Byrne
P
P
Kelly
K
K
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D037102:Lectins / Q000276:immunology / Q000378:metabolism*; D016256:Lewis X Antigen / Q000276:immunology / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D018396:Mucin-1; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D037121:Plant Lectins; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D037102:Lectins; D016256:Lewis X Antigen; D008562:Membrane Glycoproteins; D018396:Mucin-1; D037121:Plant Lectins; C036850:Ulex europaeus lectins