Effects of endothelin-1 and endothelin-3 on blood pressure in conscious hypertensive rats.
The vasopressor potencies of endothelin (ET) in SHR, DOC, and CLIP hypertensive rats were determined. Rat endothelin (ET-3) showed greater vasopressor activity in SHR. The mechanism of this greater potency and the pathogenesis of hypertension in SHR remains to be investigated.
Watanabe
T X
TX
Peptide Institute, Inc., Protein Research Foundation, Osaka, Japan.
Kumagaye
S
S
Nishio
H
H
Nakajima
K
K
Kimura
T
T
Sakakibara
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003900:Desoxycorticosterone; D016232:Endothelins; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000188:drug therapy; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D016232:Endothelins; D010455:Peptides; D003900:Desoxycorticosterone