Tumor necrosis factor induces acute phase proteins in rats.
Inoculation of WAG rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum (haptoglobin, alpha 1 acid glycoprotein, alpha 2 macroglobulin) and in the plasma (fibrinogen). We conclude that TNF may play an important role in the inflammatory response in vivo and possibly in the pathogenesis of inflammatory disorders.
Gresser
I
I
Lab. Viral Oncology, CNRS, Villejuif, France.
Delers
F
F
Tran Quangs
N
N
Marion
S
S
Engler
R
R
Maury
C
C
Soria
C
C
Soria
J
J
Fiers
W
W
Tavernier
J
J
D000209:Acute-Phase Proteins / Q000096:biosynthesis* / Q000187:drug effects; D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma