[Clinical and histological effects of cis-platinum-peplomycin chemotherapy for metastatic lymph nodes of head and neck cancer].
Clinical and histological effects of cis-platinum-peplomycin chemotherapy for metastatic lymph nodes were studied in 35 head and neck carcinomas. The results were as follows; 1. As the clinical effects, 4 cases revealed CR, 17 cases PR, and 16 cases NC. The response rate was 57%. 2. Histologically, 7 cases were classified as Grade III change, 1 case as Grade IIb change and 13 cases as Grade IIa change according to Ohboshi-Shimozato classification. 3. The clinical effects for the metastatic lymph nodes almost agreed to that for the primary lesion. 4. The histological effects for the metastatic lymph nodes almost agreed to that for the primary lesion. 5. The clinical effects for the metastatic lymph nodes did not always agree to the histological effects for it. 6. It was impossible to do radical treatment of metastatic lymph nodes with cis-platinum-peplomycin chemotherapy. In some cases, chemotherapy made it easy to do radical neck dissection.
Sato
K
K
Kurita
S
S
Ohkubo
H
H
Kawaguchi
T
T
Matsuoka
H
H
Hirano
M
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000187:drug effects; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D017663:Peplomycin
D001761:Bleomycin; D017663:Peplomycin; D002945:Cisplatin