title: Comparison between number of basophils, blood histamine, and histamine release in cancer and noncancer patients.
abstract: In cancer patients with primary tumor with or without metastasis or metastasis alone, by comparison with healthy subjects and noncancer patients, the decrease in blood histamine levels is due to a decrease in total basophil number. These basophils have a normal content of histamine (1 to 2 pg per basophil) and are able to release histamine. The percentage of anti IgE-induced histamine release is not significantly different than in noncancer patients. The scarcity of basophils in cancer patients is not due to a leukopenia. Blood histamine levels and total basophil number are normal in patients after successful excision of their primary tumor without metastasis.
authors: Faculté Necker Enfants Malades, Paris, France.
authors: L
authors: L
authors: Galoppin
authors: C
authors: C
authors: Noirot
authors: J P
authors: JP
authors: Wastiaux
authors: P
authors: P
authors: Scheinmann
authors: J
authors: J
authors: Paupe
authors: C
authors: C
authors: Burtin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001491:Basophils; D004804:Eosinophils; D005260:Female; D005500:Follow-Up Studies; D006632:Histamine / Q000097:blood*; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*
chemical_list: D007073:Immunoglobulin E; D006632:Histamine