title: In vivo release of beta human chorionic gonadotropin by luteinizing hormone releasing hormone stimulation and its clinical application as a remission criterion in patients with gestational trophoblastic disease.
abstract: In vivo responses of trophoblasts to luteinizing hormone releasing hormone (LHRH) stimulation in 48 gestational trophoblastic disease patients were observed. Serum beta human chorionic gonadotropin (beta-hCG) levels after LHRH injection were significantly increased in patients with hCG values between 5 and 20 mIU/ml (minimal resistance group) but not in patients whose hCG levels were less than 5 mIU/ml (possible remission group). The sensitivity, specificity and the predictive values of LHRH stimulation test were 75.0, 91.3 and 95.5% in the possible remission group and 87.5, 20.0 and 77.8% in the minimal resistance group.
authors: Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.
authors: S J
authors: SJ
authors: Kim
authors: J K
authors: JK
authors: Jung
authors: B C
authors: BC
authors: Kang
authors: S E
authors: SE
authors: Namkoong
authors: J W
authors: JW
authors: Lee
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011379:Prognosis; D011863:Radioimmunoassay; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D007987:Gonadotropin-Releasing Hormone