[Serum interferon level and (2'-5')-oligo(A) synthetase activity in pityriasis rosea, basalioma, melanoma and molluscum contagiosum].
In various skin diseases with a possible viral and/or autoimmune etiology, the peripheral lymphocytes were studied with regard to serum interferon levels and the interferon-induced activity of (2'-5')-oligoadenylate synthetase (OAS). This enzyme is a sensitive marker of interferon and can be detected even some days after the clearance of interferon from the blood. In patients with pityriasis rosea (n = 13), basal cell carcinoma (n = 12), malignant melanoma (n = 11), and molluscum contagiosum (n = 13), the serum interferon levels were not increased. In comparison to healthy persons, 5 patients with melanoma (Clark's levels I, I-II and II) showed a significantly elevated activity of OAS. In 6 other patients with melanoma (Clark's level III, III-IV and IV), the OAS activity was not increased. Although the elevated activity of OAS found in patients with melanoma of lower Clark's levels indicates a participation of the interferon system in the course of the disease, our results do not allow a clear statement regarding a viral and/or an autoimmune etiology of the skin disease.
Lang
M H
MH
Abteilung I des Zentrums für Dermatologie und Venerolgie, J.-W.-Goethe-Universität Frankfurt/Main.
Lodemann
E
E
Holzmann
H
H
Heimbrodt
M
M
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D008976:Molluscum Contagiosum / Q000175:diagnosis; D010915:Pityriasis / Q000175:diagnosis; D012874:Skin Diseases, Infectious / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis*; D014412:Tumor Virus Infections / Q000175:diagnosis; D014777:Virus Diseases / Q000175:diagnosis*
D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase
Serum-Interferonspiegel und (2'-5')-Oligo(A)-Synthetaseaktivität bei Pityriasis rosea, Basaliom, Melanom und Molluscum contagiosum.