[The pharmacokinetics and pharmacodynamics of the new Soviet anti-arrhythmia preparation allapinin].
Pharmacokinetics and pharmacodynamics of a new antiarrhythmic drug allapinin was studied in patients with frequent ventricular and supraventricular extrasystoles. The technique of determining allapinin by high performance liquid chromatography is described. Intravenous administration of the drug in a dose of 20 mg was shown to be effective in 50% of patients.
Abdalla
A
A
Rulin
V A
VA
Mazur
N A
NA
Chikovani
S I
SI
D000157:Aconitine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D031841:Aconitum / Q000031:analogs & derivatives*; D005117:Cardiac Complexes, Premature / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D004341:Drug Evaluation; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D013997:Time Factors
C051402:allapinin; D000157:Aconitine
Farmakokinetika i farmakodinamika novogo otechesvennogo antiaritmicheskogo preparata allapinina.