Virus-like particles associated with reverse transcriptase activity in acute sporadic non-A,non-B hepatitis.
Reverse transcriptase activity was tested in 65 patients with non-A,non-B hepatitis, with positive results in 2 acute sporadic cases with favorable outcome. Virus-like particles were observed in ultra-thin sections of successive serum samples from one of the reverse transcriptase activity-positive patients by electron microscopy. These results suggest that some non-A,non-B hepatitis types could be related to a virus-like agent associated with a reverse transcriptase activity.
Castillo
I
I
Department of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.
Carreño
V
V
Bartolomé
F J
FJ
Porres
J C
JC
Mora
I
I
Herrera
M I
MI
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000201:enzymology / Q000382:microbiology*; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012194:RNA-Directed DNA Polymerase / Q000097:blood*; D000637:Transaminases / Q000097:blood; D014766:Viremia / Q000201:enzymology*; D014771:Virion / Q000648:ultrastructure*
D000637:Transaminases; D012194:RNA-Directed DNA Polymerase