Factors influencing the choice of first-line treatment in chronic ischaemic heart disease.
The three categories of antianginal drugs--nitrates, beta-blockers, and calcium antagonists--are approximately equally effective in preventing angina. However, there is a marked intraindividual variation in response, which is only partly explained by differing underlying mechanisms. Choice of drug depends largely on other factors, such as whether or not there is severe myocardial or pulmonary dysfunction, whether there are side effects, and whether there is concomitant hypertension, a history of myocardial infarction, or arrhythmias. There is no "optimal" drug. Treatment has to be individualised.
Julian
D G
DG
University of Newcastle upon Tyne, Freeman Hospital, U.K.
D002908:Chronic Disease; D003327:Coronary Disease / Q000188:drug therapy*; D006801:Humans