Helper T-cell determinants in vaccine design.
Mice belonging to the H-2d haplotype do not respond to the 141-160 peptide of foot-and-mouth disease virus protein VP1. However, when defined 'foreign' helper T-cell determinants from ovalbumin or sperm whale myoglobin are added they do respond. These observations are likely to have important implications for the design of peptide vaccines.
Brown
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Department of Virology, Wellcome Biotechnology, Beckenham, Kent, UK.
D000818:Animals; D005537:Aphthovirus / Q000276:immunology; D000939:Epitopes / Q000302:isolation & purification; D006183:H-2 Antigens; D006239:Haplotypes; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014612:Vaccines / Q000302:isolation & purification*; D014614:Vaccines, Synthetic / Q000302:isolation & purification*; D014764:Viral Proteins / Q000276:immunology; D015678:Viral Structural Proteins
D000939:Epitopes; D006183:H-2 Antigens; D014612:Vaccines; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D015678:Viral Structural Proteins