Granular cell lesions of the jaws and oral cavity: a clinicopathologic, immunohistochemical, and ultrastructural study.
A clinicopathological, immunohistochemical, and ultrastructural study of 44 oral granular cell lesions was performed. A total of 35 mucosal granular cell tumors, 4 granular cell ameloblastomas, 1 lichen planus with granular cell change, and 3 congenital epulides of the newborn were studied. Pseudoepitheliomatous hyperplasia was found to occur in only a minority of these cases. Immunohistochemically, the majority of granular cell lesions were uniformly positive for S-100 protein and focally positive for vimentin in one half of the cases, suggestive of origin from a Schwann cell or a precursor mesenchymal cell. Congenital epulis of the newborn and central odontogenic granular cell tumor were negative for S-100 protein, epithelial membrane antigen (EMA), and prekeratin, suggesting a mesenchymal origin for these lesions.
Mirchandani
R
R
Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Sciubba
J J
JJ
Mir
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D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000032:analysis / Q000473:pathology / Q000648:ultrastructure; D002648:Child; D005260:Female; D005887:Gingival Neoplasms / Q000032:analysis / Q000151:congenital / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D008010:Lichen Planus / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism / Q000473:pathology; D009808:Odontogenic Tumors / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D013194:Staining and Labeling; D014062:Tongue Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure