Potassium channels expressed from rat brain cDNA have delayed rectifier properties.
Injection into Xenopus oocytes of RNA synthesized in vitro using the rat brain cDNA RCK1 as a template or nuclear injection of the cDNA results in the expression of functional potassium channels. These channels exhibit properties similar to those of the non-inactivating delayed rectifier channel found in mammalian neurons and other excitable cells.
Stühmer
W
W
Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.
Stocker
M
M
Sakmann
B
B
Seeburg
P
P
Baumann
A
A
Grupe
A
A
Pongs
O
O
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000032:analysis*; D004247:DNA / Q000235:genetics*; D004546:Elapid Venoms / Q000494:pharmacology; D004553:Electric Conductivity; D005260:Female; D005786:Gene Expression Regulation; D006636:Histamine Release / Q000187:drug effects; D008564:Membrane Potentials; D009865:Oocytes / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014981:Xenopus
D000631:Aminopyridines; D004546:Elapid Venoms; D010455:Peptides; D015221:Potassium Channels; D013757:Tetraethylammonium Compounds; C008331:mast cell degranulating peptide; D019789:Tetraethylammonium; C020273:dendrotoxin; D004247:DNA; D015761:4-Aminopyridine; D011188:Potassium