[Effect of cytosine arabinoside on the differentiation of granulocyte-monocyte progenitors (CFU-GM) and myeloid leukemia blasts (CFU-L) in vitro].
The serum concentrations of Ara-C are in the range from 10(-6) to 10(-8) M in LD-Ara-C treated patients. The growth of CFU-GM from bone marrow of healthy volunteers was depressed depending on Ara-C-concentration applied in vitro. The growth of CFU-L from peripheral blood of two patients with AML (M 2) and one patient with CML in blast crisis was differently influenced by Ara-C-application in vitro. An elevated proportion of mature cells was observed in smears of cultured cells with Ara-C from two patients. The usefulness of Ara-C for a differentiation inducing therapy is discussed.
Wächter
M
M
Universitätsklinik für Innere Medizin, Humboldt-Universität zu Berlin, DDR.
Goldschmidt
H
H
Blau
W
W
Elstner
E
E
Ihle
R
R
D002454:Cell Differentiation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*; D009000:Monocytes / Q000187:drug effects; D014411:Neoplastic Stem Cells / Q000187:drug effects*
D003561:Cytarabine
Der Einfluss von Cytosinarabinosid (Ara-C) auf granulozytär-monozytär determinierte Stammzellen (CFU-GM) und myeloisch-leukämische Blasten (CFU-L) in vitro.