Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats.
The effects of optical isomers of fenfluramine and their metabolites, d- and l-norfenfluramine on the serotonergic system were studied in the nucleus accumbens and hippocampus of freely moving rats by in vivo voltammetry. Both isomers and the metabolites induced a slow, sustained decrease in 5HIAA but only d-fenfluramine and its metabolite, d-norfenfluramine, increased the 5HIAA levels in nucleus accumbens shortly after injection, the increase being greater after the metabolite. No effect could be detected in the hippocampus after the higher dose of d-fenfluramine.
De Simoni
M G
MG
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Juraszczyk
Z
Z
Fodritto
F
F
De Luigi
A
A
Garattini
S
S
D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D005277:Fenfluramine / Q000378:metabolism / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D009043:Motor Activity; D009642:Norfenfluramine / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012686:Septal Nuclei / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013237:Stereoisomerism
D009642:Norfenfluramine; D005277:Fenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid