title: Measles virus-specific human T cell clones: studies of alloreactivity and antigenic cross-reactivity.
abstract: Cross-reactivity between altered self and foreign major histocompatibility complex (MHC) may be of etiologic importance in autoimmune disease. We have studied 29 measles virus-specific cloned and uncloned T cell lines from a patient with multiple sclerosis (MS) and from a normal subject. Two of the T cell clones derived from the normal subject reacted with foreign MHC determinants. No cross-reactivity between measles virus and either myelin basic protein (BP) or galactocerebroside (GC) was detected. T cell clones which are specific for nominal antigen and which also recognize alloantigen were detected with much smaller frequency than that reported in murine systems. Our data do not support a role for alloreactive measles-specific T cells, nor for cross-reactivity between measles virus and either BP or GC, in the pathogenesis of MS.
authors: Department of Neurology, Georgetown University Medical Center, Washington, DC 20007.
authors: J R
authors: JR
authors: Richert
authors: E D
authors: ED
authors: Robinson
authors: C A
authors: CA
authors: Reuben-Burnside
authors: A H
authors: AH
authors: Johnson
authors: H F
authors: HF
authors: McFarland
authors: D E
authors: DE
authors: McFarlin
authors: R J
authors: RJ
authors: Hartzman
mesh_terms: D000956:Antigens, Viral / Q000276:immunology; D002999:Clone Cells; D003429:Cross Reactions; D005699:Galactosylceramides / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation; D008459:Measles virus / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D005699:Galactosylceramides; D006680:HLA Antigens; D007519:Isoantigens; D004676:Myelin Basic Protein