Serum neopterin levels as predictor of AIDS.
The reliability of laboratory parameters for the prediction of impending manifestation of AIDS in HIV-1 infected patients was investigated. Over a mean observation period of approximately 1 year (5 to 33 months) 56 patients were studied. Eleven patients progressed to AIDS (group 1) and 45 remained free of AIDS-defining disease (group 2). Eight candidate-predictor variables were measured on each patient at the beginning of the observation period: neopterin, hemoglobin, lymphocytes, CD4 counts, CD8 counts, platelets, gammaglobulins, and erythrocyte sedimentation rate. In a linear discrimination analysis, a stepwise entry of these parameters into the discriminant function was effected according to which variable added most to the separation into groups 1 and 2. Neopterin proved to be most discriminating with no improvement of separation when adding further variables. Thus, a final allocation rule was computed using neopterin alone. This rule assigns neopterin levels above 21.9 nmol/l to group 1 and levels below to group 2. We conclude, tentatively, that in HIV-infected patients neopterin levels of 22 nmol/l and over may indicate the manifestation of AIDS in the year to come.
Bogner
J R
JR
Medizinische Poliklinik, Universität München.
Matuschke
A
A
Heinrich
B
B
Eberle
E
E
Goebel
F D
FD
D000386:AIDS-Related Complex / Q000097:blood; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood*; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D001799:Blood Sedimentation; D005260:Female; D006679:HIV Seropositivity / Q000097:blood; D006452:Hemoglobinometry; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D019798:Neopterin; D010976:Platelet Count; D011379:Prognosis; D012307:Risk Factors; D005719:gamma-Globulins / Q000378:metabolism
D005719:gamma-Globulins; D001708:Biopterins; D019798:Neopterin