[Action of hydrocortisone on the lipid composition of active and inactive chromatin fractions in the rat liver].
A composition of phospholipids and neutral lipids of rat liver chromatin and its active and inactive fractions has been investigated. It is shown that the hydrocortisone action results in marked increase in phospholipid/neutral lipid ratio of both chromatin and its active fraction. The changes in lipid content is clearly expressed in active chromatin fraction, the lipid content of inactive fraction is not changed. It is concluded that the increase of content in certain phospholipids and simultaneous decrease of neutral lipids in chromatin promotes the hormonal activation of genome.
Gevorkian
E S
ES
Iavroian
Zh V
ZhV
Minasian
A A
AA
D000818:Animals; D002843:Chromatin / Q000032:analysis / Q000187:drug effects*; D002855:Chromatography, Thin Layer; D004247:DNA / Q000032:analysis; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D010743:Phospholipids / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D008055:Lipids; D010743:Phospholipids; D012313:RNA; D004247:DNA; D006854:Hydrocortisone
Deĭstvie gidrokortizona na lipidnyĭ sostav aktivnoĭ i neaktivnoĭ fraktsiĭ khromatina pecheni krys.