title: [Experience in using anti-arrhythmia preparations of groups I and III in patients with arrhythmia resistant to therapy].
abstract: The efficiency of a number of antiarrhythmic drugs (etmozin, quinidine, mexytil, allapinin, cordarone), used alone and in combinations, was assessed in 13 patients with refractory continuous extrasystoles of varying origins. Antiarrhythmic effect of the drugs was evaluated by means of Holter ECG monitoring. Monotherapies were only effective in 3 patients, and developing side effects limited the possibilities of long-term use. Combined treatment produced a greater effect, while smaller doses of individual drugs making up the combination resulted in a better tolerance due to reduced side effects.
authors: A
authors: A
authors: Abdalla
authors: N A
authors: NA
authors: Mazur
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives*; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000008:administration & dosage; D008875:Middle Aged; D016293:Moricizine; D010640:Phenothiazines / Q000008:administration & dosage; D011802:Quinidine / Q000008:administration & dosage
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D008801:Mexiletine; D016293:Moricizine; C051402:allapinin; D011802:Quinidine; D000157:Aconitine
vernacular_title: Opyt kombinirovannogo primeneniia antiaritmicheskikh preparatov I i III grupp u bol'nykh s refrakternymi k terapii aritmiiami.