[Changes in degranulation and histamine release from mast cells in rats sensitized by penicilloyl-protein].
In this paper, the mechanism of the penicillin G anaphylactic reaction was studied. Rats were sensitized to penicilloyl (BPO)-protein. The incidences of anaphylactic reaction and death were 100 and 40%, respectively. After being challenged, the degranulation rates of rat cranial periosteous and peritoneal mast cells were 91 +/- 5 and 44 +/- 10%, respectively. In the control group, they were 11 +/- 5 and 7 +/- 2%, respectively. The histamine release rates from sensitized and control rat peritoneal mast cells were 13 +/- 2 and 3.0 +/- 0.4%, respectively. The passive cutaneous anaphylaxis (PCA) test demonstrated that the antibody titers in sensitized serum were 16-32.
Zhao
Z J
ZJ
Ma
T X
TX
D000707:Anaphylaxis / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D010323:Passive Cutaneous Anaphylaxis; D010400:Penicillin G / Q000009:adverse effects; D011506:Proteins; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D010400:Penicillin G