title: [Safety of long-term therapy with a combination of various anti-arrhythmia agents].
abstract: Safety and the effectiveness of combined therapy of arrhythmia was studied in 27 patients in prolonged (up to 4 months) administration of a combination of medicinal agents specially chosen during pharmacodynamic investigation. The obtained anti-arrhythmic effect was stable and there were no new side effects in prolonged administration of combinations of ethmozine with chinidin, ritmilen, obsidan, cordaron (amiodaron) and of allapinin with chinidin, ritmilen (disopyramide) and obsidan (propronalol). Tolerance to drugs was adequate and the ECG parameters remained unaffected.
authors: A
authors: A
authors: Abdalla
authors: N A
authors: NA
authors: Mazur
authors: A B
authors: AB
authors: Sumarokov
authors: N V
authors: NV
authors: Iavorskaia
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000633:toxicity; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents
vernacular_title: Bezopasnost' dlitel'noĭ terapii kombinatsieĭ razlichnykh antiaritmicheskikh preparatov.