title: Beta-adrenergic modulation of the alpha 2-acute phase globulin blood level in rats.
abstract: The acute phase response can be modulated by glucocorticoids and catecholamines as well. We treated Wistar rats with either epinephrine or different selective or non-selective beta-agonists in combination with beta-antagonists. The alpha 2-acute phase globulin (alpha 2-APG) serum concentrations were examined by means of electroimmunodiffusion 24 hours after drug administration. Isoprenaline, epinephrine and the beta 2-selective clenbuterol cause a dose-dependent increase in alpha 2-APG serum concentration. The increase can be inhibited by propranolol as a non-selective beta-receptor blocking agent. beta 1-antagonist talinolol has no effect on the alpha 2-APG serum level. The dose-response curve of isoprenaline is shifted to the right and that of clenbuterol is additionally depressed after treatment with propranolol. According to the alpha 2-APG level the results indicate a beta 2-receptor mediated epinephrine action.
authors: Department of Medicine (Charité), Humboldt University of Berlin, GDR.
authors: M
authors: M
authors: Kahl
authors: R
authors: R
authors: Schade
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D000511:alpha-Macroglobulins / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D000511:alpha-Macroglobulins; D004837:Epinephrine