Fibrin monomer complexes (SFMC) after substitution of antithrombin III (AT III) in consumption coagulopathy.
The report refers to substitution therapy of 33 patients who suffered consumption coagulopathy. Various blood coagulation and fibrinolytic variables were measured. After successful AT III donation to patients suffering DIC, soluble fibrin monomer complexes (SFMC) disappeared within 0.5-12 hours. If AT III decreases SFMC proves positive again. In addition to analysis of AT III we recommend to analyse SFMC to detect thrombin induced consumption reaction (DIC). Furthermore we found the fibrin split product D-dimer was a particularly sensitive indicator of DIC in case of hyperfibrinolysis (D-dimer was analysed in six patients). The reactions of fibronectin and SFMC proved inversely proportional.
Töpfer
G
G
District Hospital of Görlitz, GDR.
Ehrhardt
W
W
Dornheim
G
G
Seifert
A
A
Schmidt
L H
LH
Senger
C
C
Funke
U
U
Schulze
M
M
D000293:Adolescent; D000990:Antithrombin III / Q000627:therapeutic use*; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000188:drug therapy; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male
D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; D000990:Antithrombin III