Capsaicin-induced release of substance P-like immunoreactivity from the guinea pig stomach in vitro and in vivo.
Capsaicin induced a release of substance P-like immunoreactivity (SP-LI) in superfusates from gastric fundic mucosa of guinea pig in vitro and from gastric perfusates of anaesthetized guinea pigs in vivo. Tissue SP-LI from the gastric fundus was reduced (43.4%) by systemic capsaicin desensitization. These findings provide direct neurochemical evidence which supports the hypothesis for the involvement of local neuropeptide release in the 'gastric defence mechanism' played by capsaicin-sensitive nerves.
Renzi
D
D
Department of Clinical Pathophysiology, University of Florence, Italy.
Santicioli
P
P
Maggi
C A
CA
Surrenti
C
C
Pradelles
P
P
Meli
A
A
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000294:innervation*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D002211:Capsaicin