Lupus-related transcript homologous to Abelson-murine leukemia virus.
In the present study, we found the expression of transcripts homologous to Abelson murine leukemia virus (A-MuLV) in lupus-prone mice and nonautoimmune mice. One of them, as the lupus-related transcript, is expressed in only lupus-prone mice and induced by bacterial lipopolysaccharide (LSP). We could not induce the transcript by LSP in nonautoimmune mice that we examined. The significance of the transcript autoimmune events in lupus-prone mice is discussed.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Negoro
S
S
Kishimoto
S
S
D000011:Abelson murine leukemia virus / Q000235:genetics*; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D005814:Genes, Viral; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009857:Oncogenes; D012313:RNA / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014775:Virus Activation
D008070:Lipopolysaccharides; D012313:RNA