Discrimination of the determinant specificity of two competitive Semliki Forest virus neutralizing monoclonal antibodies by anti-idiotypic antibodies.
The two highly competitive, monoclonal antibodies (MAs), UM 5.1 and UM 8.1, recognize on the E2 glycoprotein of Semliki Forest virus different determinants as indicated by the absence of cross-reactive anti-idiotypic antibodies in rabbit immune sera induced against these highly neutralizing MAs.
Oosterlaken
T A
TA
Laboratorium voor Microbiologie, Rijksuniversiteit Utrecht, The Netherlands.
Kraaijeveld
C A
CA
Snijders
A
A
Harmsen
M
M
Benaissa-Trouw
B J
BJ
Snippe
H
H
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001667:Binding, Competitive; D000939:Epitopes / Q000032:analysis*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007739:L Cells; D051379:Mice; D009500:Neutralization Tests; D012672:Semliki forest virus / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*; D014776:Virus Cultivation
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D014764:Viral Proteins