Possible proarrhythmic effects of tocainide in dilated cardiomyopathy.
A patient with a dilated cardiomyopathy experienced a cardiac arrest when taking tocainide for asymptomatic nonsustained ventricular tachycardia. After successful resuscitation from ventricular fibrillation and exclusion of a myocardial infarction, an electrophysiological evaluation was performed. Drug-free study #1 revealed no induction of ventricular tachycardia. A tocainide study revealed induction of sustained monomorphic ventricular tachycardia. Drug-free study #2 revealed induction of nonsustained ventricular tachycardia. This report illustrates a possible proarrhythmic effect of tocainide.
Brownstein
S L
SL
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City.
Constantin
L
L
Kienzle
M G
MG
Martins
J B
JB
D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000139:chemically induced*; D016677:Tocainide
D016677:Tocainide; D008012:Lidocaine