The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites.
This report suggests that the release of various inflammatory mediators such as histamine, LTC4, D4 and E4, and TXA2 measured as the stable metabolite TXB2 are partly responsible for the various cardiac and renal effects of the complement fragment C5a des Arg anaphylatoxin, in addition to its direct vasoconstrictor activity.
Ghanem
N S
NS
Department of Pharmacology, University College London, UK.
Abdullah
N A
NA
Assem
E S
ES
D000818:Animals; D003182:Complement C5 / Q000031:analogs & derivatives* / Q000502:physiology; D015937:Complement C5a, des-Arginine; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology; D006636:Histamine Release; D066298:In Vitro Techniques; D007668:Kidney / Q000276:immunology* / Q000502:physiology; D015289:Leukotrienes / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000276:immunology*; D010477:Perfusion; D013929:Thromboxane B2 / Q000378:metabolism
D003182:Complement C5; D015937:Complement C5a, des-Arginine; D015289:Leukotrienes; D013929:Thromboxane B2