Effect of the N-terminal tetrapeptide of substance P SP (1-4) and tuftsin on the pre- and postsynaptic transmitter outflow in rat adrenal gland slices.
Two structurally related tetrapeptides, the N-terminal tetrapeptide of substance P SP(1-4) and tuftsin, exerted some similarities in modifying immune reactions and normalizing stress-induced disorders in the catecholamine system of adrenals. This paper presents results about the effects of tuftsin and SP(1-4) on the cholinergic-adrenergic interaction in rat adrenal gland slices. Both, tuftsin and SP(1-4) inhibited the nicotine-evoked [3H]noradrenaline outflow (postsynaptic effect), but the effect of SP(1-4) was more pronounced. SP(1-4) also inhibited the electrically stimulated [3H]ACh outflow (presynaptic effect), whereas tuftsin did not affect the ACh outflow. It is suggested that the regulation of the cholinergic-adrenergic interaction in adrenals is mediated by specific receptors, which are different on the pre- and postsynaptic side.
Nieber
K
K
Institute of Drug Research, Academy of Sciences of the GDR, Berlin.
Oehme
P
P
Arefolov
V A
VA
Valdman
A V
AV
D000109:Acetylcholine / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013373:Substance P / Q000494:pharmacology*; D014405:Tuftsin / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D010446:Peptide Fragments; D013373:Substance P; C042612:substance P (1-4); D009538:Nicotine; D000109:Acetylcholine; D014405:Tuftsin