Clonal variation in the impact of ethyl methanesulfonate and 5-azacytidine on the metastatic phenotype of human prostatic tumor cells in athymic nude mice.
Parallel in vitro exposure to 5-azacytidine or to ethyl methanesulfonate either significantly reduced or had no major impact on the experimental metastasis capacity of different clones of the human prostatic carcinoma subline 1-LN-PC-3-1A. The impact of these agents on metastatic capacity varied (1) among different clones and (2) between clones and the uncloned parental line. Analysis of the process by which these agents modify the metastatic phenotype of human tumor cells may offer insight into the process of phenotypic diversification.
Ware
J L
JL
Department of Pathology, Medical College of Virginia/Virginia Commonwealth University, Richmond.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D002999:Clone Cells / Q000187:drug effects / Q000502:physiology; D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000503:physiopathology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000502:physiology
D005020:Ethyl Methanesulfonate; D001374:Azacitidine