Grooming behavior induced by substance P.
The intracerebroventricular (i.c.v.) administration of substance P elicits in rats an excessive grooming that is characterized by body grooming, anogenital grooming and scratching. The total grooming scores displayed by rats treated with substance P hardly exceeded 23% of the theoretical maximal grooming score. Substance P-induced excessive grooming was suppressed by pretreatment with naloxone, haloperidol on neurotensin. It is concluded that substance P induces excessive grooming with a pattern different from that of grooming elicited by other peptides.
Van Wimersma Greidanus
T B
TB
Rudolf Magnus Institute of Pharmacology, University of Utrecht, The Netherlands.
Maigret
C
C
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006120:Grooming / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D009270:Naloxone; D009496:Neurotensin; D006220:Haloperidol