Effect of Z-103 on compound 48/80-induced gastric lesions in rats.
Z-103 (a novel anti-ulcer agent), given p.o. at doses of 30 and 100 mg/kg, significantly prevented gastric lesions induced by compound 48/80 in rats. Z-103 inhibited the histamine release from rat peritoneal mast cells stimulated by compound 48/80 in a dose-dependent manner. Z-103 inhibited the increase in thiobarbituric acid (TBA) reactants induced by a single or repeated administration of compound 48/80 in the gastric mucosa. These observations suggested that the protective effect of Z-103 against compound 48/80-induced gastric lesions may be due to its stabilizing activity toward mast cells and/or an antioxidative effect on the gastric mucosa.
Ueki
S
S
Department of Biological Sciences, Central Research, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Seiki
M
M
Yoneta
T
T
Omata
T
T
Hori
Y
Y
Ishikawa
M
M
Tagashira
E
E
D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives*; D005753:Gastric Mucosa / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D009942:Organometallic Compounds / Q000494:pharmacology*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology*; D013858:Thiobarbiturates; D017967:Zinc Compounds; D003189:p-Methoxy-N-methylphenethylamine
D009942:Organometallic Compounds; D013858:Thiobarbiturates; D017967:Zinc Compounds; C061957:polaprezinc; D003189:p-Methoxy-N-methylphenethylamine; D006639:Histidine; D002336:Carnosine; C029684:thiobarbituric acid