Persistent light reaction. Successful treatment with cyclosporin A.
A 53-year-old male patient who had suffered for several years from severe persistent light reaction possibly due to tribromsalan photosensitivity was treated with cyclosporin A after long-term low-dose administration of corticosteroids which had to be discontinued. PUVA therapy was impracticable due to the extraordinarily high UVA sensitivity. When cyclosporin A blood concentrations between 100 and 200 ng/ml were reached, the patient was nearly free from symptoms; the excellent clinical response was also documented by phototesting performed prior to and during therapy. Cyclosporin A may be a valuable therapeutic alternative to systemic corticosteroids for severe cases of persistent light reaction which cannot be controlled by photoprotective measures.
Duschet
P
P
Department of Dermatology, Hospital Vienna-Lainz, Austria.
Schwarz
T
T
Oppolzer
G
G
Gschnait
F
F
D000890:Anti-Infective Agents / Q000009:adverse effects; D003524:Cyclosporins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000188:drug therapy* / Q000276:immunology; D012458:Salicylanilides / Q000009:adverse effects; D012867:Skin / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects
D000890:Anti-Infective Agents; D003524:Cyclosporins; D012458:Salicylanilides; C004361:tribromsalan