title: Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: a possible new mechanism for hypoxia-induced vasodilatation of the rat heart.
abstract: In this report we demonstrate the immunocytochemical localization of serotonin in endothelial cells of rat coronary vessels and a significant increase in the release of serotonin into the perfusate of Langendorff rat heart preparations during hypoxia. It is suggested that serotonin, localized in endothelial cells, is released during hypoxia and could provide part of a pathophysiological mechanism for vasodilatation to protect the heart from damage due to hypoxia.
authors: Department of Anatomy and Developmental Biology, University College, London, England.
authors: G
authors: G
authors: Burnstock
authors: J
authors: J
authors: Lincoln
authors: E
authors: E
authors: Fehér
authors: A M
authors: AM
authors: Hopwood
authors: K
authors: K
authors: Kirkpatrick
authors: P
authors: P
authors: Milner
authors: V
authors: V
authors: Ralevic
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D000860:Hypoxia / Q000503:physiopathology*; D007124:Immunoenzyme Techniques; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D014664:Vasodilation
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid