title: Aprotinin inhibits the hormone binding of the estrogen receptor from calf uterus.
abstract: Micromolar concentrations of the proteinase inhibitor, aprotinin, produced a dose-dependent inhibition in the binding capacity of the estrogen receptor from calf uterus. Aprotinin inhibition was greater at 28 degrees C than at 4 degrees C and only occurred when conditions allowed the receptor transformation. When aprotinin was tested in the presence of transformation inhibitors, its effect was no longer seen. The binding capacity of the highly purified estrogen-binding subunit was similarly inhibited.
authors: Istituto di Patologia Generale ed Oncologia, I Facoltà di Medicina e Chirurgia, Napoli, Italy.
authors: V
authors: V
authors: Nigro
authors: N
authors: N
authors: Medici
authors: C
authors: C
authors: Abbondanza
authors: S
authors: S
authors: Minucci
authors: A M
authors: AM
authors: Molinari
authors: G A
authors: GA
authors: Puca
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002417:Cattle; D002846:Chromatography, Affinity; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000494:pharmacology; D011960:Receptors, Estrogen / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
chemical_list: D011480:Protease Inhibitors; D011960:Receptors, Estrogen; D004958:Estradiol; D007611:Aprotinin