title: Effects of protamine on histamine release from human lung.
abstract: Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparin-protamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for protamine reactions in man.
authors: Department of Anesthesia, Emory University School of Medicine, Atlanta, GA 30322.
authors: J H
authors: JH
authors: Levy
authors: B A
authors: BA
authors: Faraj
authors: J R
authors: JR
authors: Zaidan
authors: V M
authors: VM
authors: Camp
mesh_terms: D000888:Antibodies, Anti-Idiotypic; D006493:Heparin / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D011479:Protamines / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D011479:Protamines; D007073:Immunoglobulin E; D006493:Heparin