Anaphylactic shock: catecholamine actions in the responses to opioid antagonists.
The pathophysiological consequences of endorphin release in anaphylactic shock were investigated through pharmacological studies using opiate antagonists (naloxone, naltrexone, natrexone methyl bromide) as well as agonists (morphine, beta-endorphin). These studies suggest that induction of anaphylaxis provokes the release of endogenous opioids, possibly from the hypothalamus, which contribute to the shock process by stimulating opiate receptors in the CNS. The mechanism of pathophysiologic action of endorphin in anaphylaxis involves, at least in part, inhibition of the central component of the sympatho-adrenalmedullary system. This results in reduced effectiveness of the sympathetic system to physiologically reverse the circulatory effects of the toxic mediators of anaphylaxis. Naloxone, by blocking endorphin action at CNS opiate receptors located at autonomic regulatory centers (e.g. hypothalamus), reverses the sympatho-inhibitory effect of the endorphin peptides. This results in increased central sympathetic outflow to peripheral sympathetic neuroeffector mechanisms; it affords improved sympathetic compensatory responses and increases survival. TRH and DT gamma E physiologically oppose the action of endorphins upon the autonomic system. They stimulate central sympathetic mechanisms through their own receptor systems and increase outflow to peripheral sympathetic effectors. This also results in improved circulatory function and survival.
Amir
S
S
Center for Neurosciences and Behavioural Research, Weizmann Institute of Science, Rehovot, Israel.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D018823:gamma-Endorphin
D002395:Catecholamines; D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone; D018823:gamma-Endorphin