title: Acute acoustic trauma. A retrospective study of influencing factors and different therapies in 268 patients.
abstract: The files of 268 patients with acute acoustic trauma acquired during military service were analysed in a retrospective study. The following factors were examined: age, profession, degree of hearing loss, audiometric contour, and drug treatment. No influence of age or profession on recovery of hearing loss could be detected. The absolute hearing gain, defined as the difference between the hearing loss at onset and, on average, 7 days later, was dependent on the degree of initial hearing loss. The relative hearing gain, defined as absolute hearing gain divided by initial hearing loss, was independent of the degree of initial injury. The audiometric contour after the acoustic trauma had no prognostic relevance. Nine different types of drug treatment were compared in a subgroup of patients (n=199), in all of whom treatment was started within 2 days of the acoustic trauma. There were no significant differences in relative hearing gain between the nine types of treatment. Patients receiving early treatment had significantly better hearing one week after the acoustic trauma, as compared with the group of patients (n=69) not receiving treatment during the first 7 days. However, it was not possible to determine retrospectively whether this difference was due to treatment effects, or whether it was due to the exclusion of spontaneous remissions among those who were neither examined nor treated within the first 7 days.
authors: Department of Otorhinolaryngology, University of Basle, Switzerland.
authors: K
authors: K
authors: Tschopp
authors: R
authors: R
authors: Probst
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D002245:Carbon Dioxide / Q000627:therapeutic use; D003911:Dextrans / Q000627:therapeutic use; D004224:Diterpenes; D005389:Firearms; D046934:Ginkgolides; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007783:Lactones / Q000627:therapeutic use; D008889:Military Personnel; D010431:Pentoxifylline / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D012189:Retrospective Studies; D013557:Switzerland
chemical_list: D003911:Dextrans; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D002245:Carbon Dioxide; C045856:ginkgolide B; D010431:Pentoxifylline