Serological and genetic study of the ELA W21 specificity.
Investigations on the W21 specificity showed that this antigen is expressed on lymphocytes and platelets but not on erythrocytes. The molecule carrying the antigen W21 moves in the cell membrane independently from ELA locus A and B encoded antigens, as observed in 'lysostripping'. The W21 specificity occurs with very different gene frequencies in various breeds. In informative families it segregates together with defined gene products of the MHC region. The data suggest strongly that the W21 specificity belongs to the ELA system as a class I gene product, but is governed by a separate locus than the known locus A and locus B allelic series.
Hirni
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Klinik fur Nutztiere und Pferde, School of Veterinary Medicine, University of Berne, Switzerland.
Lazary
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Gerber
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D000042:Absorption; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000276:immunology*; D005787:Gene Frequency; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology*; D006736:Horses / Q000235:genetics* / Q000276:immunology; D008285:Major Histocompatibility Complex; D011995:Recombination, Genetic; D013045:Species Specificity
D000939:Epitopes; D006649:Histocompatibility Antigens