[The population composition of cultures of Vibrio cholerae strain 569 B Pakistan in relation to the manufacture of a cholera vaccine (choleragen-anatoxin+O-antigen)].
The study of different subcultures of V. cholerae strain 569 B Pakistan, used as the source of choleragen in the production of cholera vaccine, has been made. The composition of the population formed by this strain has been found to be heterogeneous with respect to toxin formation. The control of changes occurring in the production culture by analyzing its population composition has been proposed.
Lobanov
V V
VV
Nechetskaia
R M
RM
Adamova
G V
GV
D000818:Animals; D000833:Animals, Suckling; D000942:Antigens, Bacterial / Q000276:immunology / Q000302:isolation & purification*; D002772:Cholera Toxin / Q000096:biosynthesis / Q000276:immunology / Q000302:isolation & purification*; D022121:Cholera Vaccines / Q000276:immunology / Q000302:isolation & purification*; D005612:Freeze Drying; D019081:O Antigens; D011309:Preservation, Biological / Q000379:methods; D011817:Rabbits; D012692:Serial Passage; D014121:Toxoids / Q000276:immunology / Q000302:isolation & purification*; D014734:Vibrio cholerae / Q000254:growth & development* / Q000276:immunology
D000942:Antigens, Bacterial; D022121:Cholera Vaccines; D019081:O Antigens; D014121:Toxoids; C038458:cholera toxoid; D002772:Cholera Toxin
Izuchenie populiatsionnogo sostava kul'tur Vibrio cholerae shtamma 569 B Pakistan v sviazi s proizvodstvom kholernoĭ vaktsiny (kholerogen-anatoksin+O-antigen).