Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner.
Prior exposure (priming) of BALB/cByJ mice to a low dose of lipopolysaccharide derived from Escherichia coli 055 or Serratia marcescens, followed by immunization with an optimally immunogenic dose of the same lipopolysaccharide 2 to 30 days later, results in the expression of substantially reduced antibody responses. Such unresponsiveness, which is antigen specific, occurs in a cyclic manner with time after priming.
Elkins
K L
KL
Twinbrook II Research Facility, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852.
Stashak
P W
PW
Baker
P J
PJ
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000939:Epitopes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007156:Immunologic Memory; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010507:Periodicity; D012706:Serratia marcescens / Q000276:immunology
D000907:Antibodies, Bacterial; D000939:Epitopes; D008070:Lipopolysaccharides