title: Serum protein electrophoresis in spontaneous canine hyperadrenocorticalism.
abstract: The serum protein concentrations of dogs with confirmed spontaneous hyperadrenocorticalism were determined by agarose gel electrophoresis before and during treatment with mitotane. In untreated animals a significant increase was detected in the mean concentration of total protein and the mean concentration and percentage of alpha-2 globulin. The mean concentration and percentage of albumin and gamma-globulin were significantly decreased. In animals on treatment the mean concentration of total proteins and the mean concentration and percentage of beta-2 globulin were significantly reduced.
authors: Department of Veterinary Clinical Studies, Royal (Dick) School of Veternary Studies, Summerhall, Edinburgh.
authors: A H
authors: AH
authors: van den Broek
authors: J
authors: J
authors: Lida
mesh_terms: D000303:Adrenal Cortex Diseases / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D000510:Alpha-Globulins / Q000032:analysis; D000818:Animals; D001609:Beta-Globulins / Q000032:analysis; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis*; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D008939:Mitotane / Q000627:therapeutic use; D012709:Serum Albumin / Q000032:analysis; D005719:gamma-Globulins / Q000032:analysis
chemical_list: D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D012709:Serum Albumin; D005719:gamma-Globulins; D008939:Mitotane