[Effect of a change in the effectiveness of a benzodiazepine-GABA-ionophore complex blockade on the reproduction of an amnesic memory trace in mice after preliminary diazepam administration].
The paper deals with the results of analysis of the influence of blocked of BD-GABA-ionophore complex and its separate components on recover of memory trace amnesia during BD-receptors activation in experiments on elaboration of CR of passive avoidance in mice. It is shown that at "neurochemical tuning" the improvement of conditioned reaction reproduction on the 2-nd and 21-st day after learning and amnestic action was observed only at GABAA receptor blockade by bicuculline, while the blockade of BD-receptor by flumazepil and of chlorine channel by picrotoxin was ineffective. Simultaneous blockade of all BD-GABA-ionophore complex components was not more effective in comparison with the blockade of its separate links in the recovery of conditioned reaction reproduction. The presented data allow to suppose that "psychogenic" amnesia development is determined by the functional state of neurotransmitter brain systems at learning and amnestic action which stipulates subsequent possibility of memory trace retrieval.
Il'iuchenok
R Iu
RIu
Dubrovina
N I
NI
Parkhomenko
R I
RI
D000647:Amnesia / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001640:Bicuculline / Q000494:pharmacology; D002713:Chlorine / Q000378:metabolism*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010852:Picrotoxin / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D001640:Bicuculline; D002713:Chlorine; D003975:Diazepam; D005442:Flumazenil; D007473:Ion Channels; D010852:Picrotoxin; D011963:Receptors, GABA-A
Vliianie izmeneniia éffektivnosti blokady benzodiazepin-GAMK-ionoforngo kompleksa na vosproizvedenie amnezirovannogo sleda pamiati u mysheĭ posle predvaritel'nogo vvedeniia diazepama.