Inhibition of HIV replication by liposomal encapsulated amphotericin B.
This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibiting the growth of HIV. Virus expression was suppressed at a concentration of 5-10 micrograms/ml of the drugs. The liposomal preparation showed greatly reduced cytotoxicity in experiments using cultures of murine leukocytes. These results show the potential usefulness of liposomal encapsulated drugs in the treatment of patients with AIDS or AIDS related complex.
Pontani
D R
DR
New Jersey Department of Health, Trenton 08625.
Sun
D
D
Brown
J W
JW
Shahied
S I
SI
Plescia
O J
OJ
Schaffner
C P
CP
Lopez-Berestein
G
G
Sarin
P S
PS
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002461:Cell Line, Transformed; D003168:Complement Fixation Tests; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D005455:Fluorescent Antibody Technique; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008081:Liposomes; D051379:Mice; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014779:Virus Replication / Q000187:drug effects*
D000914:Antibodies, Viral; D004337:Drug Carriers; D007074:Immunoglobulin G; D008081:Liposomes; D000666:Amphotericin B; D012194:RNA-Directed DNA Polymerase