The influence of plasma catecholamines on methotrexate-enhanced rat salivary gland protein secretion.
The acetylcholine-elicited secretory output of parotid protein and amylase, and of submandibular protein from rats receiving 15 mg methotrexate (MTX)/kg for 3 days were 3-6 times greater than that from control animals. Plasma epinephrine and norepinephrine levels in MTX-treated animals were 4-14 times greater than control values. Adrenalectomy reduced the plasma-catecholamine levels, and the acetylcholine-stimulated salivary protein and amylase output. Thus MTX-enhanced salivary protein secretion evoked by acetylcholine stimulation may be mediated, at least in part, by elevated levels of circulating catecholamines.
McBride
R K
RK
Department of Pharmacology, University of Illinois College of Medicine at Urbana, Champaign 61801.
Siegel
I A
IA
D000109:Acetylcholine / Q000494:pharmacology; D000315:Adrenalectomy; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004837:Epinephrine / Q000097:blood*; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D013268:Stimulation, Chemical
D012471:Salivary Proteins and Peptides; D000681:Amylases; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine; D008727:Methotrexate