Incomplete replication of human parainfluenza virus type 2 in mouse L929 cells.
Human parainfluenza virus type 2 (HPIV-2) was tested for its ability to replicate in murine L929 cells. L929 cells were non-permissive for replication of HPIV-2. Interferon produced endogenously played no role in its incomplete replication. The mechanism by which growth of HPIV-2 was suppressed in L929 cells was studied. Synthesis of virus-specific polypeptides, particularly glycoprotein(s), was suppressed in HPIV-2-infected L929 cells. The HN mRNA could scarcely be detected in virus-infected L929 cells.
Ito
Y
Y
Department of Microbiology, Mie University School of Medicine, Japan.
Tsurudome
M
M
Bando
H
H
Komada
H
H
Nishio
M
M
D000818:Animals; D002478:Cells, Cultured; D015342:DNA Probes; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007372:Interferons / Q000502:physiology; D010223:Parainfluenza Virus 2, Human / Q000254:growth & development / Q000502:physiology*; D010252:Paramyxoviridae / Q000254:growth & development / Q000502:physiology; D010452:Peptide Biosynthesis; D011233:Precipitin Tests; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis / Q000302:isolation & purification; D018108:Respirovirus / Q000502:physiology*; D014035:Togaviridae / Q000254:growth & development / Q000502:physiology; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000096:biosynthesis; D014776:Virus Cultivation; D014779:Virus Replication
D015342:DNA Probes; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins; D007372:Interferons