Mechanisms of anesthesia-induced depression of myocardial function.
Anesthetics may depress myocardial function. Part of this action is due to a direct negative inotropic effect of these agents. With the increasing knowledge on the cardiac excitation-contraction process, the understanding of the different possible mechanisms, underlying the anesthetic-induced myocardial depression also increases. The present state of knowledge on these possible mechanisms is reviewed and they are discussed as to their relative importance and their clinical relevance.
De Hert
S
S
Department of Anesthesiology, University Hospital Antwerp, Edegem.
Adriaensen
H
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D000777:Anesthetics / Q000494:pharmacology*; D003285:Contractile Proteins / Q000187:drug effects; D003864:Depression, Chemical; D006019:Glycolysis / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D012508:Sarcolemma / Q000187:drug effects
D000777:Anesthetics; D003285:Contractile Proteins; D007473:Ion Channels; D000255:Adenosine Triphosphate