The role of dynein in retrograde axonal transport.
Fast axonal transport is manifested at the sub-cellular level as the anterograde or retrograde movement of membrane-bounded organelles along microtubules. Earlier work implicated the protein kinesin as the motor for anterograde axonal transport. More recent work indicates that a brain microtubule-associated protein, MAP 1C, is responsible for retrograde transport. Of additional interest, MAP 1C has been found to be a cytoplasmic form of the ciliary and flagellar ATPase dynein, indicating a much more general functional role for this enzyme in cells than had been suspected.
Vallee
R B
RB
Shpetner
H S
HS
Paschal
B M
BM
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D004398:Dyneins / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology*
D000251:Adenosine Triphosphatases; D004398:Dyneins