Renal transplantation in baboons under FK 506.
FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 +/- 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 +/- 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial.
Todo
S
S
Department of Surgery, University of Pittsburgh, Pa.
Demetris
A
A
Ueda
Y
Y
Imventarza
O
O
Cadoff
E
E
Zeevi
A
A
Starzl
T E
TE
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006084:Graft Rejection; D007166:Immunosuppressive Agents; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D009026:Mortality; D010215:Papio; D011725:Pyridines / Q000494:pharmacology*; D016559:Tacrolimus; D013997:Time Factors
D007166:Immunosuppressive Agents; D011725:Pyridines; D016559:Tacrolimus