[Effect of contrical on the lysosomal proteinase activity of the gastric mucosa of rats in experimental ulcer].
Total and non-sedimentable activities of lysosomal proteinases were studied in rat gastric mucose under conditions of normal state and of ulcer development as well as after treatment of the ulcer area with contrical and with the mixture containing contrical and medical glue MK-8. Both total activity of cathepsins A, B, C and D and their non-sedimentable activity were increased by 32-102% and 44-94%, respectively, under conditions of ulcerogenesis. Contrical and the mixture of the drug with glue MK-8 normalized the enzymatic activity studied; the mixture containing the inhibitor was the most effective. Inhibitors of proteinases combined with medical plastificators might be used in local treatment of stomach ulcerous disease.
Dzodzuashvili
V U
VU
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D010450:Endopeptidases / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy / Q000201:enzymology*
D011480:Protease Inhibitors; D007611:Aprotinin; D010450:Endopeptidases
Vliianie kontrikala na aktivnost' lizosomal'nykh proteinaz v slizistoĭ obolochke zheludka krys pri éksperimental'noĭ iazve.