Inhibitory effect of intracranial injections of tachykinins on angiotensin-induced drinking in the cat.
The tachykinins eledoisin, substance P and kassinin were administered by pulse intracerebroventricular (ICV) injections to cats made thirsty by ICV angiotensin II, 100 ng per cat. Eledoisin, 100 ng per cat, produced an inhibition of drinking which was larger (56.0 vs. 45.2%) and lasted longer than that evoked by 400 ng per cat of substance P. Kassinin, 100 ng per cat, did not evoke any effect at all. The treatment with these peptides neither produced signs of discomfort nor induced any other behavioural alteration. The results of present experiments suggest that the antidipsogenic effect of tachykinins is a phenomenon of general interest among mammals.
Barocelli
E
E
Institute of Pharmacology and Pharmacognosy, University of Parma, Italy.
Chiavarini
M
M
Impicciatore
M
M
Massi
M
M
de Caro
G
G
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004327:Drinking Behavior / Q000187:drug effects*; D004600:Eledoisin / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D015286:Kassinin / Q000494:pharmacology*; D008297:Male; D013373:Substance P / Q000494:pharmacology*
D000804:Angiotensin II; D013373:Substance P; D015286:Kassinin; D004600:Eledoisin