Biological effect of alkoxymethylene trimethylammonium chlorides on yeast Saccharomyces cerevisiae.
Six compounds of the group of quaternary ammonium salts have been tested for their biological activity using yeasts as a biological system. They have an inhibitory effect on respiration, cell growth and amino acid transport. A destroying action on protoplast regeneration and respiration has been also observed. The studied chemicals appear to have very pleiotropic action, focused on a damage of mitochondrial and cell plasma membranes.
Skała
J
J
Department of Genetics, Wrocław University, Poland.
Orłowska-Matuszewska
G
G
Misiewicz
M
M
Oświecimska
M
M
Witek
S
S
Kotylak
Z
Z
D000596:Amino Acids / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
D000596:Amino Acids; D000644:Quaternary Ammonium Compounds