title: Some properties of two erythromycin-dependent strains of Escherichia coli.
abstract: Strains of Escherichia coli can be isolated that require erythromycin for growth. With one strain, AM, a range of antibiotics, including chloramphenicol, tetracycline, spectinomycin, kasugamycin and rifampicin, will substitute for erythromycin on solid and in liquid media; nalidixic acid supports growth in liquid but not on solid media. With a second strain, 103, chloramphenicol, tetracycline and spectinomycin support growth in liquid media but on solid medium only chloramphenicol substitutes for erythromycin. In media of higher than normal ionic strength, strain AM, but not strain 103, can grow in the absence of antibiotics. Possible reasons for these complex phenotypes are discussed.
authors: Department of Biochemistry, University of Oxford, UK.
authors: B A
authors: BA
authors: Maguire
authors: J K
authors: JK
authors: Deaves
authors: D G
authors: DG
authors: Wild
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D002701:Chloramphenicol / Q000378:metabolism; D003470:Culture Media; D004269:DNA, Bacterial / Q000096:biosynthesis; D004917:Erythromycin / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D010641:Phenotype; D012329:RNA, Bacterial / Q000096:biosynthesis; D012293:Rifampin / Q000378:metabolism; D000198:Spectinomycin / Q000378:metabolism; D013752:Tetracycline / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003470:Culture Media; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D004917:Erythromycin; D002701:Chloramphenicol; D000198:Spectinomycin; D013752:Tetracycline; C100305:kasugamycin; D012293:Rifampin