Urinary levels of biogenic amine metabolites in mentally retarded children.
Urinary total catecholamines, their metabolites and metabolite of serotonin were estimated in 32 mentally retarded children and 15 controls. Levels of total catecholamines. MHPG and 5-HIAA were not significantly different from controls. However, the mean VMA and HVA excretion in mentally retarded children was significantly increased compared to the control group. It is concluded that an altered metabolism of dopamine is involved in mental retardation.
Nalini
K
K
Department of Clinical Biochemistry, Kasturba Medical College, Karnataka, India.
Aroor
A R
AR
Rao
A
A
D000293:Adolescent; D001679:Biogenic Amines / Q000652:urine*; D002648:Child; D003404:Creatinine / Q000652:urine; D005260:Female; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008607:Intellectual Disability / Q000652:urine*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine
D001679:Biogenic Amines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D003404:Creatinine; D006719:Homovanillic Acid