Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient.
A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient.
Blanken
R
R
Department of Dermatology, University Hospital Groningen, The Netherlands.
Doeglas
H M
HM
de Jong
M C
MC
Kardaun
S H
SH
van Leeuwen
M
M
D002216:Captopril / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*
D002216:Captopril; D010396:Penicillamine