title: HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells.
abstract: The molecules encoded by the major histocompatibility complex play a pivotal role in regulatory interactions between cells of the immune system, which can result in the activation and function of T cells. The function of the CD1 molecules, which are homologous to the major histocompatibility complex-encoded molecules but are encoded on human chromosome 1, is not known. HLA class I molecules and CD1a heavy chains share the ability to associate with several different cell-surface molecules. We show here, by several technical approaches, that HLA class I molecules are associated with CD1a heavy chains on the surface of normal thymus cells. The functional significance of this association during T-cell differentiation is discussed.
authors: Institut National de la Santé et de la Recherche Médicale, Hôpital Saint-Louis, Paris, France.
authors: M
authors: M
authors: Amiot
authors: H
authors: H
authors: Dastot
authors: L
authors: L
authors: Degos
authors: J
authors: J
authors: Dausset
authors: A
authors: A
authors: Bernard
authors: L
authors: L
authors: Boumsell
mesh_terms: D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D000943:Antigens, Differentiation / Q000032:analysis*; D002648:Child; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D046911:Macromolecular Substances; D010449:Peptide Mapping; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D000943:Antigens, Differentiation; D006680:HLA Antigens; D046911:Macromolecular Substances