[Effect of a single oral dose of allapinin in patients with chronic ventricular extrasystole].
Effect of a new antiarrhythmic drug allapinin was studied in 21 patients with chronic ventricular extrasystoles by an acute drug test with single oral dose of the drug controlled by 12-hour Holter monitoring. In 9 cases the dose was 50 mg. Maximal total reduction of ventricular ectopic complexes (VEC) per hour was 67 +/- 28% (mean value); in 5 cases (55%) it exceeded 90% of basal level. At peak of action, PQ interval increased by 15%, QRS--by 14%, QT was not significantly changed. In 14 cases the dose was 75 micrograms. Maximal VEC number reduction per hour was on the average 89 +/- 18% and in 12 cases (88%) exceeded 90%. PQ increased by 22%, QRS--by 23% and QT by 9% though JT was not changed (average peak values). It is thus concluded that single oral dose of allapinin has pronounced antiarrhythmic effect in patients with VEC and influences ECG intervals in the way characteristic for class IC antiarrhythmic drugs. The degree of the effect depends on the dose.
Sokolov
S F
SF
Alikhanov
G N
GN
Golitsyn
S P
SP
Koltunova
M I
MI
Smetnev
A S
AS
D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D031841:Aconitum / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000328:Adult; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
C051402:allapinin; D000157:Aconitine
Deĭstvie allapinina pri odnokratnom prieme vnutr' u bol'nykh s khronicheskoĭ zheludochkovoĭ ekstrasistolieĭ.