Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin.
Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
Pessina
G P
GP
Institute of General Physiology, University of Siena, Italy.
Muscettola
M
M
Paulesu
L
L
Bocci
V
V
D000418:Albumins; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000494:pharmacology* / Q000031:analogs & derivatives; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D011070:Poly I-C / Q000008:administration & dosage / Q000494:pharmacology*; D011107:Polylysine / Q000008:administration & dosage / Q000494:pharmacology* / Q000031:analogs & derivatives; D011817:Rabbits
D000418:Albumins; D007369:Interferon Inducers; D011107:Polylysine; C019531:poly ICLC; D008747:Methylcellulose; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C