The ultrastructure of epithelioid sarcoma.
We have described clinical, histological immunohistochemical and ultrastructural features of four typical examples of epithelioid sarcoma. Smooth-muscle-type focal densities amid fine actin-like filaments in typical epithelioid cells often containing prominent rER have been observed, as well as a structure in the form of a densely granular cytoplasmic body. These features are suggestive of myofibroblastic differentiation. A tumour with light microscopy features typical of epithelioid sarcoma but of spindle-cell appearance is also described. Ultrastructurally this consists of myofibroblasts and it is suggested that this may be an unusual variant in which myofibroblastic differentiation is a major feature.
Eyden
B P
BP
Department of Histopathology, Christie Hospital, University of Manchester, U.K.
Harris
M
M
Banerjee
S S
SS
McClure
J
J
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D014746:Vimentin / Q000378:metabolism
D014746:Vimentin; D007633:Keratins