[A quantitative method of determining middle molecule peptides in the blood serum of patients with chronic renal insufficiency].
Gel chromatography and high performance liquid chromatography have been applied to analysis of the blood serum peptides in renal patients. The levels of the peptides with a molecular mass of 300-5000 D have been found to correlate with the severity of the kidney involvement. A rapid method for measuring the concentrations of these peptides has been developed, based on the precipitation of the blood serum high-molecular peptides followed by measurement of the concentration of the peptides remaining in the supernatant with the use of a specific reagent. The suggested method has been used to define the severity of the kidney involvement and to monitor the efficacy of hemodialysis and hemoperfusion.
Salikhova
N N
NN
Akhmedzhanov
R I
RI
Mukhamadieva
Sh G
ShG
Sakhibov
A D
AD
D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D010455:Peptides / Q000097:blood*
D010455:Peptides
Kolichestvennyĭ metod opredeleniia srednemolekuliarnykh peptidov v syvorotke krovi bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu.