Galanin immunoreactivity in human CSF: studies in eating disorders and Alzheimer's disease.
Galanin is a peptide which stimulates feeding behavior in animals and is found within those basal forebrain cholinergic neurons which degenerate in Alzheimer's disease. Galanin was measured in cerebrospinal fluid (CSF) by radioimmunoassay. The nature of the immunoreactivity was characterized chromatographically as authentic galanin. CSF galanin levels were determined in subjects with Alzheimer's disease, involutional depression, anorexia nervosa and bulimia. No differences between any diagnostic group and age and sex-matched controls were found.
Berrettini
W H
WH
National Institute of Mental Health, Bethesda, Md.
Kaye
W H
WH
Sunderland
T
T
May
C
C
Gwirtsman
H E
HE
Mellow
A
A
Albright
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid*; D002032:Bulimia / Q000134:cerebrospinal fluid*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid; D005260:Female; D019004:Galanin; D006801:Humans; D008297:Male; D010455:Peptides / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay
D010455:Peptides; D019004:Galanin