title: Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists.
abstract: The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343. Analysis of the dose-response curves for contraction and inositol phosphates accumulation with these agonists demonstrated a direct relationship between the two parameters, with a considerable reserve of inositol phosphate production for the full contractile agonists, methacholine and oxotremorine, and no reserve for the partial agonist, McN-A-343.
authors: Department of Pharmacology and Therapeutics, University of Groningen, The Netherlands.
authors: H
authors: H
authors: Meurs
authors: A F
authors: AF
authors: Roffel
authors: J B
authors: JB
authors: Postema
authors: A
authors: A
authors: Timmermans
authors: C R
authors: CR
authors: Elzinga
authors: H F
authors: HF
authors: Kauffman
authors: J
authors: J
authors: Zaagsma
mesh_terms: D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D007295:Inositol Phosphates / Q000378:metabolism; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D018727:Muscarinic Antagonists; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D010095:Oxotremorine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000502:physiology; D014132:Trachea / Q000187:drug effects / Q000378:metabolism
chemical_list: D007295:Inositol Phosphates; D008688:Methacholine Compounds; D018727:Muscarinic Antagonists; D010716:Phosphatidylinositols; D011976:Receptors, Muscarinic; D016210:Methacholine Chloride; D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; D010095:Oxotremorine