[Morphometric study of the myocardial T-+L-system under the influence of the beta-adrenergic agent fenoterol].
In order to evaluate possible cardiotoxic properties of the beta adrenergic agent fenoterol, the effect of fenoterol alone and in combination with verapamil and prednisolone respectively was examined regarding the myocardial T- and L-system of 54 female rabbits. Five study groups and one control group measured the width morphometrically of the T- and L-system in electronmicroscopical pictures of the myocardium after treating the animals accordingly. A relevant dilatation of the T- and L-system was not found in this study, neither by morphological evaluation of the electron-microscopical pictures, nor in the morphometric-statistical analysis of the measurements in both experimental and control groups. Therefore, no pathological effects concerning the width of the T- and L-system could be found by applying fenoterol alone or in combination with the calcium antagonist verapamil and prednisolone respectively for tocolytic purposes.
Meinen
K
K
Geburtshilflich-Gynäkologische Abteilung, St. Lukas-Klinik, Solingen-Ohligs.
Jansky
M
M
Stofft
E
E
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects*; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D011239:Prednisolone / Q000031:analogs & derivatives / Q000494:pharmacology; D011247:Pregnancy; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D007473:Ion Channels; D005280:Fenoterol; D011239:Prednisolone; D014700:Verapamil; C021322:prednisolone hemisuccinate; D002118:Calcium
Morphometrische Untersuchung des myokardialen T- + L-Systems unter Einfluss des Betaadrenergikums Fenoterol.