Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate.
Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) belong to a family of glycoprotidic growth factors required for the survival, growth and differentiation of haematopoietic precursors and which affect the function of circulating mature cells. They are produced by resting or stimulated stromal cells of the haematopoietic microenvironment (fibroblasts and endothelium) and by immunocompetent cells (T cells and monocytes/macrophages). The action of these CSF molecules was thought to be restricted to cells of haematopoietic origin. Here, we report that G-CSF and GM-CSF influence the migration and proliferation of human endothelial cells suggesting that these molecules may act as regulatory signals outside the haematopoietic system.
Bussolino
F
F
Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italy.
Wang
J M
JM
Defilippi
P
P
Turrini
F
F
Sanavio
F
F
Edgell
C J
CJ
Aglietta
M
M
Arese
P
P
Mantovani
A
A
D002455:Cell Division; D002460:Cell Line; D002465:Cell Movement; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology*; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes; D006133:Growth Substances / Q000494:pharmacology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007375:Interleukin-1; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor