title: Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia.
abstract: Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed.
authors: University College London, Department of Anatomy and Developmental Biology, United Kingdom.
authors: P
authors: P
authors: Milner
authors: V
authors: V
authors: Ralevic
authors: A M
authors: AM
authors: Hopwood
authors: E
authors: E
authors: Fehér
authors: J
authors: J
authors: Lincoln
authors: K A
authors: KA
authors: Kirkpatrick
authors: G
authors: G
authors: Burnstock
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000032:analysis / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism / Q000648:ultrastructure*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis / Q000378:metabolism*
chemical_list: D013373:Substance P; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine; D010100:Oxygen