title: Heterogeneity of the isolated subunits of the fetal and adult human hemoglobin in solution, detected by XANES spectroscopy.
abstract: Differences in the local structure of the heme in the isolated alpha-, beta- and gamma-chains of the adult and fetal human hemoglobin are detected by XANES (X-ray absorption near-edge structure) spectroscopy. The ligand bonding angle to the iron ion in the ligated forms and the displacement of the Fe respect to the porphyrin plane in the deoxy forms are found to be different for each chain.
authors: Dipartimento di Fisica, Università La Sapienza, Roma, Italy.
authors: A
authors: A
authors: Congiu Castellano
authors: M
authors: M
authors: Castagnola
authors: E
authors: E
authors: Burattini
authors: M
authors: M
authors: Dell'Ariccia
authors: S
authors: S
authors: Della Longa
authors: A
authors: A
authors: Giovannelli
authors: P J
authors: PJ
authors: Durham
authors: A
authors: A
authors: Bianconi
mesh_terms: D002248:Carbon Monoxide; D005319:Fetal Hemoglobin / Q000032:analysis* / Q000502:physiology; D006441:Hemoglobin A / Q000032:analysis* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D010100:Oxygen; D013057:Spectrum Analysis / Q000379:methods; D013329:Structure-Activity Relationship; D014965:X-Rays
chemical_list: D002248:Carbon Monoxide; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; D010100:Oxygen