Effect of interleukin-1 on the augmentation of human immunodeficiency virus gene expression.
Among the cytokines tested here (IL-2, IL-3, IL-4, IL-5, IL-6, granulocyte colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GM-CSF), interferon-alpha (IFN-alpha), interferon-beta (IFN-beta) and interferon-gamma (IFN-gamma] only interleukin 1(IL-1) augmented HIV-long terminal repeat(LTR) directed chloramphenicol acetyl transferase(CAT) activity in protein kinase C(PKC)-independent manner. However, a stimulation by IL-1 was not as efficient as that due to tumor necrosis factor and the HIV production was not significant. IL-1 was not cytotoxic to MOLT-4/HIV cells.
Kobayashi
N
N
Department of Virology and Parasitology, School of Medicine, Yamaguchi University, Japan.
Hamamoto
Y
Y
Koyanagi
Y
Y
Chen
I S
IS
Yamamoto
N
N
D000470:Alkaloids / Q000494:pharmacology; D001685:Biological Factors / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D016207:Cytokines; D015870:Gene Expression / Q000187:drug effects*; D005814:Genes, Viral / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology; D006678:HIV / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D007378:Interleukins / Q000494:pharmacology; D007700:Kinetics; D012091:Repetitive Sequences, Nucleic Acid; D019311:Staurosporine
D000470:Alkaloids; D001685:Biological Factors; D016207:Cytokines; D006133:Growth Substances; D007375:Interleukin-1; D007378:Interleukins; D007372:Interferons; D015500:Chloramphenicol O-Acetyltransferase; D019311:Staurosporine