title: Habenular modulation of dynorphinergic systems in rat ventral mesencephalon.
abstract: Bilateral electrolytic lesion of the striatonigral pathways (which convey massive afferents to the substantia nigra) caused a marked lowering of alpha-neo-endorphin (alpha-Neo) and dynorphin A(1-8) [Dyn A(1-8)] levels in the substantia nigra without affecting the alpha-Neo content in the ventral tegmental area. Moreover, unilateral infusion of the axon sparing neurotoxin ibotenate into the striatum, but not into the substantia nigra, decrease these two opioid peptides in the substantia nigra on the side ipsilateral to the lesion, failing to modify the alpha-Neo levels in the ventral tegmental area. Bilateral electrolytic lesion of the habenula augmented alpha-Neo content in the substantia nigra and ventral tegmental area at 8-30 days postlesion without affecting the nigral Dyn A(1-8). These results add further support to the view that alpha-Neo- and Dyn A(1-8)-containing neurons projecting to the substantia nigra originate in the striatum and descend through striatonigral pathways. The present data provide evidence that the habenula may participate in the regulation of the activity of alpha-Neo-immunoreactive neurons in the substantia nigra and ventral tegmental area.
authors: Division of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan.
authors: H
authors: H
authors: Ichikawa
authors: T
authors: T
authors: Nishikawa
authors: H
authors: H
authors: Mitsushio
authors: M
authors: M
authors: Takashima
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004399:Dynorphins / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D007051:Ibotenic Acid / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013373:Substance P / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D004723:Endorphins; D010446:Peptide Fragments; D011498:Protein Precursors; D007051:Ibotenic Acid; D013373:Substance P; D005680:gamma-Aminobutyric Acid; C025681:alpha-neoendorphin; D004399:Dynorphins; C026770:dynorphin (1-8)