title: Effects of various doses of SP 54 on fibrinolytic activity in patients with thrombotic diseases.
abstract: SP 54 was synthetized more than 30 years ago, but the proper oral dosage has not been established yet. Therefore we gave two doses. 150 and 500 mg to patients suffering from various arterial and venous thrombotic diseases, for investigating the dose-response effect. 16 patients received 150 mg, 14 patients 500 mg and 10 in each group both doses. We could observe significant changes in ELT, WBL and plasminogen level, but the increase of fibrinolytic activity was not dose-dependent in most cases. It indicates that an individual dosage is needed. Therefore we suggest an "SP 54 loading test" before prescribing the drug.
authors: First Department of Internal Medicine, Medical School Pécs, Hungary.
authors: H
authors: H
authors: Losonczy
authors: I
authors: I
authors: Nagy
authors: M
authors: M
authors: Dávid
mesh_terms: D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester