title: The influence of the trichorzianin C-terminal residues on the ion channel conductance in lipid bilayers.
abstract: Four natural trichorzianin analogues, channel-forming peptaibols, differing in their C-terminal residues (Gln or Glu, Trpol or Pheol) were tested for their macroscopic and single-channel conductances in planar lipid bilayers. The results indicate that, as regards to the voltage threshold, the most efficient analogue is the charged Trpol-bearing one. In addition, Trpol brings about a drastic lengthening of the open channel life-times. This behaviour is attributed to the dipole moment of the end residues and to the bulkiness and hydrogen bonding ability of Trpol.
authors: Polymères, Biopolymères Membranes' URA 500 CNRS, Faculté des Sciences de Rouen, Mont Saint Aignan, France.
authors: H
authors: H
authors: Duclohier
authors: G
authors: G
authors: Molle
authors: G
authors: G
authors: Spach
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D004553:Electric Conductivity; D006860:Hydrogen Bonding; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D008969:Molecular Sequence Data; D054848:Peptaibols; D010455:Peptides / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007473:Ion Channels; D008051:Lipid Bilayers; D054848:Peptaibols; D010455:Peptides; C039715:trichorzianine