Monoclonal IgM gammopathy with anti-myelin associated glycoprotein (MAG) activity and polyneuropathy. A study of three cases.
The authors describe three patients with a chronic sensory-motor polyneuropathy associated with a monoclonal IgM gammopathy. In each case, the M-component was shown to display an antibody activity against the Myelin-Associated Glycoprotein (MAG) in a western blot technique. Sera from the three patients stained specifically the myelin sheaths of normal human peripheral nerves after incubation with rabbit anti-IgM. Motor conduction velocities were very low in each case. Morphological studies of the sural nerve from one patient revealed a moderate loss of myelinated fibres, some onion-bulbs but also a microangiopathy and signs of axonal degeneration.
Sindic
C J
CJ
Laboratoire de Neurochimie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique.
Boucquey
D
D
Bisteau
M
M
Laloux
P
P
Brucher
J M
JM
Laterre
C
C
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D004576:Electromyography; D005260:Female; D005528:Foot / Q000294:innervation; D006801:Humans; D007075:Immunoglobulin M; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010265:Paraproteinemias / Q000150:complications*; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology
D001323:Autoantibodies; D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein