title: Endoplasmic storage disease of liver: characterization of intracytoplasmic hyaline inclusions.
abstract: Two cases of endoplasmic storage disease of liver are described. The liver tissue in each case showed numerous intracytoplasmic hyaline inclusions of varying sizes with formation of ground-glass hepatocytes. These inclusions were pale eosinophilic in hematoxylin & eosin stained sections, and were periodic acid-Schiff and HBsAg negative. Immunoperoxidase studies revealed strong positivity for fibrinogen and complement components C3 and C4 in case 1 and exclusive positivity for fibrinogen in case 2. On electron microscopy, the inclusions appeared as granular or fibrillar material within dilated cisternae of rough endoplasmic reticulum.
authors: Department of Pathology, University of Hong Kong, Queen Mary Hospital.
authors: I O
authors: IO
authors: Ng
authors: M
authors: M
authors: Ng
authors: E C
authors: EC
authors: Lai
authors: P C
authors: PC
authors: Wu
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000473:pathology*; D005340:Fibrinogen / Q000378:metabolism; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D002479:Inclusion Bodies / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000150:complications; D008297:Male
chemical_list: D003176:Complement C3; D003181:Complement C4; D005340:Fibrinogen