Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans.
The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to approximately 230% of basal levels (p less than 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to approximately 130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.
McMurray
J
J
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland.
McFarlane
L
L
Coutie
W
W
Balfour
D
D
Struthers
A
A
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D011448:Prostaglandin Antagonists; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine; D013997:Time Factors
D011448:Prostaglandin Antagonists; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin; D015232:Dinoprostone