A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes.
Hyperpolarization of oocytes of Xenopus laevis usually elicits mainly passive currents. However, when polarized to potentials more negative than about -100 mV, oocytes obtained from some donors show a relatively well maintained current that is carried mainly by chloride ions. This response does not depend upon external calcium, and is thus clearly different from the calcium-dependent transient chloride current previously described.
Parker
I
I
Department of Psychobiology, University of California, Irvine 92717.
Miledi
R
R
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007473:Ion Channels / Q000378:metabolism; D008564:Membrane Potentials; D009865:Oocytes / Q000378:metabolism*; D014982:Xenopus laevis
D002712:Chlorides; D007473:Ion Channels; D002118:Calcium