Enhancement of aflatoxin B1-induced hepatocarcinogenesis in rats by partial hepatectomy.
The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Non-hepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain.
Rizvi
T A
TA
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Mathur
M
M
Nayak
N C
NC
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D003043:Cocarcinogenesis; D006498:Hepatectomy; D008114:Liver Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000032:analysis
D000348:Aflatoxins; D000509:alpha-Fetoproteins; D016604:Aflatoxin B1