[Effect of the active immunization of rats with a serotonin-protein conjugated antigen on the content of biogenic amines in the brain and on behavioral reactions].
Active immunization of rats with conjugated antigen serotonin-protein decreased the level of serotonin and its metabolite 5-hydroxyindole-3-acetic acid in some brain structures as well as the level of dopamine in the hypothalamus. The induction of antibodies to serotonin decreased the horizontal movement activity in the animals.
Basharova
L A
LA
Vetrilé
L A
LA
Evseev
V A
VA
Gromova
E A
EA
Bobkova
N V
NV
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000276:immunology*; D001522:Behavior, Animal / Q000502:physiology*; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007114:Immunization / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D001679:Biogenic Amines; D012710:Serum Albumin, Bovine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
Vliianie aktivnoĭ immunizatsii krys kon''iugirovannym antigenom serotonin-belok na soderzhanie biogennykh aminov v mozge i povedencheskie reaktsii.