title: [Dependence of the damage and recovery of nucleic acid metabolism on the dose rate in tritium oxide exposure].
abstract: Disturbance and normalization of nucleic acid metabolism in rat thymus was studied after the effect of tritium oxide delivered in similar cumulative doses but at different dose rates. Both the disturbance and normalization were shown to be a function of dose rate, the slightest damage and the complete recovery being registered at the lowest dose rate (the amount of tritium oxide administered being 0.37 MBq/g/day). The rate of restoration was also a function of dose rate; with tritium oxide dose of 1.85 MBq/g/day (the dose rate at the stage of the equilibrium tritium content in the aqueous phase being 0.38 Gy/day) it was 9 times as high as that after a dose of 0.37 MBq/g/day (0.11 Gy/day dose rate).
authors: V B
authors: VB
authors: Shorokhova
authors: G S
authors: GS
authors: Mushkacheva
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D012313:RNA / Q000096:biosynthesis / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium / Q000009:adverse effects*; D014867:Water / Q000009:adverse effects*
chemical_list: D014867:Water; D014316:Tritium; C033961:tritium oxide; D012313:RNA; D004247:DNA
vernacular_title: Zavisimost' porazheniia i vosstanovleniia metabolizma nukleinovykh kislot ot moshchnosti dozy pri deĭstvii okisi tritiia.