[Histochemical studies of transepidermal elimination of nevus cells in nevus cell nevi of the corium].
Dermal nevocytic nevi (NN) were histochemically studied with the help of FITC-conjugated lectins as well as antisera against keratin and plasminogen activators of the urokinase type. 3 out of 18 NN showed interpenetrating nevus cells in atrophic parts of the epidermis. These cells revealed strong lectin reactivity both with Con A (cytoplasmatic binding) and WGA/RCA II (membraneous binding). In addition we found membraneous reaction with anti-urokinase, whereas there was no anti-keratin staining. Our findings suggest active transepidermal elimination of nevus cells in dermal nevocytic nevi.
Wollina
U
U
Universitäts-Hautklinik Jena, Friedrich-Schiller-Universität.
Schaarschmidt
H
H
Henkel
U
U
Knopf
B
B
Hipler
C
C
D005455:Fluorescent Antibody Technique; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007633:Keratins / Q000032:analysis; D009508:Nevus, Pigmented / Q000473:pathology*; D011975:Receptors, Mitogen / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D011975:Receptors, Mitogen; D007633:Keratins
Histochemische Untersuchungen zur transepidermalen Elimination von Nävuszellen bei korialen Nävuszellnävi.