title: [Primary manifestation of Wegener's granulomatosis of the prostate].
abstract: In approximately 2-7% of patients with Wegener's granulomatosis involvement of the prostate has been demonstrated histologically. This usually comes about quite late in the course of disease, after generalization of the granulomatous vasculitis from respiratory tract to kidneys and other organs. The patient we present had a highly atypical first manifestation of Wegener's granulomatosis in the prostate, generalized vasculitis not developing until later. When a biopsy shows unclear granulomatous changes in the prostate, a test for anticytoplasmatic antibodies should be performed in addition to the conventional serologic and cultural examinations. Anticytoplasmatic antibodies are highly specific for the diagnosis of active Wegener's granulomatosis. Early diagnosis and immediate initiation of immunosuppressive therapy with cyclophosphamide and corticosteroids can prevent or limit organ damage and improve the prognosis in Wegener's granulomatosis.
authors: Abteilung Röntgendiagnostik Radiologischen Universitätsklinik, Freiburg.
authors: A
authors: A
authors: Mundinger
authors: K
authors: K
authors: Pumpe
authors: G
authors: G
authors: Grosser
authors: E W
authors: EW
authors: Herbst
authors: W
authors: W
authors: Grotz
authors: T
authors: T
authors: Kröpelin
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D003593:Cytoplasm / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000473:pathology; D011467:Prostate / Q000473:pathology; D011469:Prostatic Diseases / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology; D001748:Urinary Bladder Neck Obstruction / Q000473:pathology
chemical_list: D001323:Autoantibodies
vernacular_title: Primärmanifestation einer Wegener'schen Granulomatose in der Prostata.