[The effect of tuberculous intoxication and tuberculostatic preparations on pancreatic excretory function].
The excretory function of the pancreas was examined intraduodenally in 78 patients with various forms of pulmonary tuberculosis. There was a decrease in its exocrine function. It was shown that the medium and conditions in the duodenum cavity affected the enzyme activity in it. The intraduodenal amylolytic activity was lowered and no effects of the antituberculous drugs on it was observed. The intraduodenal proteolytic activity was increased. which was due to tuberculous intoxication and the pharmacological action of the tuberculostatic drugs, especially PASA. The causes of the adverse dyspeptic reactions in the patients subjected to the specific therapy including PASA were revealed.
Plemiannikova
G I
GI
D000328:Adult; D000681:Amylases / Q000378:metabolism; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000503:physiopathology*
D000995:Antitubercular Agents; D000681:Amylases; D010447:Peptide Hydrolases
Vliianie tuberkuleznoĭ intoksikatsii i tuberkulostaticheskikh preparatov na ékskretornuiu funktsiiu podzheludochnoĭ zhelezy.