title: Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.
abstract: Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma.
authors: Department of Chemistry, University College London.
authors: K B
authors: KB
authors: Leung
authors: K C
authors: KC
authors: Flint
authors: J
authors: J
authors: Brostoff
authors: B N
authors: BN
authors: Hudspith
authors: N M
authors: NM
authors: Johnson
authors: H Y
authors: HY
authors: Lau
authors: W L
authors: WL
authors: Liu
authors: F L
authors: FL
authors: Pearce
mesh_terms: D001249:Asthma / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology; D008407:Mast Cells / Q000378:metabolism*; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology*; D012507:Sarcoidosis / Q000473:pathology; D013618:Tachyphylaxis
chemical_list: D015363:Quinolones; D017835:Nedocromil; D004205:Cromolyn Sodium