[The effect of substance P on the neuronal activity of the antinociceptive system].
The experiments on rats showed that the 1 micrograms substance P injection to dorsal raphe nucleus caused prolonged (24 hours of study) analgetic effect--it enhances the reaction latent period to thermal nociceptive stimulation, intensifies the background impulse activity, rises the middle frequency of neuron discharges and creates high-frequency neurons as well as the neurons with burst impulse activity. The supposition is being confirmed that the mechanism of antinociceptive structures activation leads to analgesia caused by substance P.
Kryzhanovskiĭ
G N
GN
Igon'kina
S I
SI
Trubetskaia
V V
VV
Oehme
P
P
Odariuk
Iu
Iu
D000818:Animals; D006358:Hot Temperature; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P
Vliianie substantsii P na aktivnost' neĭronov antinotsitseptivnoĭ sistemy.