Metabolic extraction of dopamine in the canine lungs.
Pulmonary metabolism has been demonstrated to be one of the mechanisms of intrapulmonary removal of dopamine. After a bolus injection of [14C]dopamine into the caval vein of an anaesthetized dog a removal of [14C]-radioactivity into the extravascular space was accompanied by an intravascular alteration of the composition of the [14C]compounds during a single transpulmonary passage. A removal of 22% of [14C]-radioactivity out of the bloodstream, together with a metabolic conversion of the remaining [14C]dopamine within the bloodstream, resulted in a total pulmonary extraction of 22% + (0.78 x 18%) = 36%. This report gives a design for further investigation of the metabolic function of the lung sustained by a scheme for problem solving. Also perspectives for clinical application have been compiled.
van Schaik
F W
FW
Medical Physiology Department, University of Utrecht, The Netherlands.
van Heeswijk
G M
GM
Huisman
G H
GH
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D006439:Hemodynamics; D006719:Homovanillic Acid / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D011652:Pulmonary Circulation; D012119:Respiration
C001746:3-methoxytyramine; D004298:Dopamine; D006719:Homovanillic Acid