Alterations of fetal brain biogenic amine metabolites by maternal ethanol exposure.
1. Pregnant Sprague-Dawley rats treated chronically with ethanol (3 g/kg daily for the last third of pregnancy) had decreased placental weights at birth (ca 23%). 2. Whole fetal brain levels of HVA and 5-HIAA were similarly decreased 32 and 38%, respectively. 3. MHPG levels were also marginally reduced (i.e. 15% decline). 4. In the presence of a potent type A MAO inhibitor (harmaline, 10 mg/kg maternal weight 2 hr before fetal delivery) co-treatment with ethanol was found to result in a 60% elevation of whole fetal brain norepinephrine levels. 5. Other biogenic amines and metabolites were not altered by ethanol treatment.
Okonmah
A D
AD
College of Pharmacy, Florida A & M University, Clinical Research Unit, Miami 33142.
Brown
J W
JW
Owasoyo
J O
JO
Soliman
K F
KF
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000196:embryology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006246:Harmaline / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D000431:Ethanol; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006246:Harmaline; D006719:Homovanillic Acid