Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue.
In 12 elderly patients, plasma, prostatic secretion and adenoma tissue concentrations of fleroxacin were determined 1-4 h following oral administration of 400 mg. The plasma concentrations ranged between 0.4 and 5.5 micrograms/ml (median 3.7 micrograms/ml), the mean tissue concentrations were slightly higher. The concentrations in prostatic secretion were about one third of the simultaneous plasma concentrations. High concentrations of the concomitantly administered ioxithalamic acid in prostatic secretion are considered as indicative of urinary contamination, and in this case the fleroxacin concentrations are questionable. The drug levels in prostatic adenoma tissue were similar to the concomitantly measured plasma levels.
Kees
F
F
Department of Pharmacology, University of Regensburg, FRG.
Naber
K G
KG
Schumacher
H
H
Grobecker
H
H
D000284:Administration, Oral; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D016576:Fleroxacin; D006801:Humans; D007275:Injections, Intravenous; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000378:metabolism*
D007483:Iothalamic Acid; D002939:Ciprofloxacin; D016576:Fleroxacin