[Temperature influence on human testicular function--optimal temperature for testicular macromolecular synthesis].
Precursor incorporations into DNA, RNA and protein fractions of the human testicular tissue were examined at 28 degrees C-43 degrees C in vitro to study the optimal temperature for DNA, RNA and protein synthesis in the human testis. The results suggest that the DNA synthesis shows delicate temperature sensitivity and is at a maximum at 31 degrees C, whereas the RNA and protein syntheses are at a maximum at 37 degrees C-40 degrees C. The slight variation of the testicular temperature may cause spermatogenic dysfunction because of delicate temperature sensitivity of the testicular DNA synthesis.
Nakamura
M
M
Nonomura
N
N
Namiki
M
M
Okuyama
A
A
Koh
E
E
Kondoh
N
N
Takeyama
M
M
Kiyohara
H
H
Fujioka
H
H
D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D013696:Temperature; D013737:Testis / Q000378:metabolism / Q000502:physiology*
D046911:Macromolecular Substances; D012313:RNA; D004247:DNA