Photoperiodic variation in substance P induced plasma extravasation in the rat.
Photoperiodic variation in plasma extravasation was examined following exogenous perfusion of substance P over a vacuum-induced blister base on the rat hind footpad. The results showed a generalised suppression of plasma extravasation during the dark or active phase of the light/dark cycle which appears to be independent of the circadian fluctuations in endogenous corticosterone. These findings emphasise the need to consider photoperiodic conditions as a possible source of variability in neurogenic inflammatory responses.
Gibson
S J
SJ
National Research Institute of Gerontology and Geriatric Medicine Department of Medicine, University of Melbourne, Mount Royal Hospital, Parkville, Vic. Australia.
Andrews
P V
PV
Helme
R D
RD
D000818:Animals; D003345:Corticosterone / Q000097:blood; D007249:Inflammation / Q000503:physiopathology*; D008027:Light; D008297:Male; D010949:Plasma / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors
D013373:Substance P; D003345:Corticosterone