Mls determinants and anti-Mls receptors.
We review evidence from this laboratory that T cell recognition of Mlsa determinants is not controlled solely by the alpha-beta T cell receptor (TcR) molecule. We propose a model in which Mlsa recognition reflects a receptor-ligand interaction between two sets of complementary accessory molecules, one molecule (Mlsa) being expressed on B cells and the other (the anti-Mlsa receptor) on T cells; this interaction augments recognition of self class II molecules by the TcR. The biological role of Mls molecules might be to facilitate physiological T-B interaction.
Webb
S R
SR
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Okamoto
A
A
Sprent
J
J
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D014018:Tissue Distribution
D000954:Antigens, Surface; D000939:Epitopes; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic