Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker.
Conjunctival leucoplakia was induced by the local beta-blocker metipranolol in one case. Withdrawal of the drug and application of all-trans retinoic acid ointment resulted in resolving of the keratinisation. A striking pharmacological resemblance is discovered between metipranolol and practolol. Metipranolol seems to be a less toxic phenol derivative of practolol. Nevertheless, it seems able to act as antigen.
Derous
D
D
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
de Keizer
R J
RJ
de Wolff-Rouendaal
D
D
Soudijn
W
W
D055598:Chemical Phenomena; D002621:Chemistry; D003229:Conjunctival Diseases / Q000139:chemically induced* / Q000473:pathology; D004837:Epinephrine / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D014290:Metipranolol / Q000009:adverse effects* / Q000378:metabolism; D008875:Middle Aged; D011412:Propanolamines / Q000009:adverse effects*
D011412:Propanolamines; D007633:Keratins; C015173:dipivefrin; D014290:Metipranolol; D004837:Epinephrine