A case of Gilbert's syndrome combined with macroamylasemia.
A 30-year-old Japanese male, who had no remarkable family history, visited our hospital with a complaint of abdominal pain, and unconjugated hyperbilirubinemia and hyperamylasemia were observed. He showed negative hemolysis tests, positive nicotinic acid test, low hepatic bilirubin UDP-glucuronyltransferase activity, decreased bilirubin diglucuronide and increased bilirubin monoglucuronide in bile, and a decrease in serum bilirubin after phenobarbital administration. He also showed high serum amylase level, low urine amylase level, and low amylase-creatinine clearance ratio. Gel filtration of serum with Sephadex G-200 revealed the existence of macroamylase. Countercurrent immunoelectrophoresis proved binding of serum amylase to lambda type IgA. From these results, the case was diagnosed as Gilbert's syndrome combined with macroamylasemia.
Inoue
H
H
Second Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Japan.
Adachi
Y
Y
Yamashita
M
M
Nanno
T
T
Katoh
H
H
Enomoto
M
M
Suwa
M
M
Yamamoto
T
T
D000328:Adult; D000681:Amylases / Q000097:blood*; D005878:Gilbert Disease / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000097:blood*; D046911:Macromolecular Substances; D008297:Male
D046911:Macromolecular Substances; D000681:Amylases; C001663:macroamylase