Effects of fibrin glue on rat facial nerve regeneration.
Studies of nerve repair comparing fibrin glue with suture techniques have produced mixed results. To test the effect of fibrin glue on nerve regeneration without the confounding variables of distraction and/or movement of the anastomosis, nerve repairs were performed with and without fibrin glue on the intratemporal facial nerve of the rat. The location of the nerve transection was the same for control and experimental nerves, but on the experimental side the nerve was repaired with fibrin glue and on the control side of the nerve was reapproximated in the fallopian canal, without glue or sutures. Axon counts distal to the repair revealed no statistically significant difference between the two methods of repair. This result suggests that mechanical obstruction by the fibrin glue between the nerve ends has a negligible effect on nerve regeneration.
Medders
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Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD 21205.
Mattox
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DE
Lyles
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A
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005154:Facial Nerve / Q000502:physiology*; D020220:Facial Nerve Injuries; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D013536:Suture Techniques; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin