[The pharmacology of recombinant hirudin].
A review about comprehensive studies on pharmacological properties of hirudin produced by genetic engineering is given. Anticoagulant effects, influence on platelet functions, studies on toxicity and side effects as well as the pharmacokinetic behaviour and antithrombotic actions of this highly effective thrombin inhibitor are described.
Kaiser
B
B
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004285:Dogs; D005343:Fibrinolytic Agents; D006629:Hirudins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D051381:Rats; D011994:Recombinant Proteins
D005343:Fibrinolytic Agents; D006629:Hirudins; D011994:Recombinant Proteins
Zur Pharmakologie von rekombinantem Hirudin.