Serum lipid changes during acitretin (etretin) treatment of psoriasis and palmo-plantar pustulosis.
The effects of acitretin (free acid of etretinate) on the serum lipoprotein pattern and on the fat elimination in serum of 8 patients with psoriasis and 4 with palmo-plantar pustulosis were studied. The drug was given for 12 weeks; the average daily dose was 40 mg. Lipoprotein analyses and an intravenous fat tolerance test (IVFTT) were performed on three occasions (before, after 8 weeks' treatment, as well as 8 weeks after the end of the treatment). Acitretin increased the triglyceride concentration of the very low density lipoproteins by about 50% (p less than 0.02) and reduced the cholesterol of the high density lipoproteins significantly (p less than 0.001), leading to an increased low density/high density lipoprotein cholesterol ratio (p less than 0.02). The IVFTT indicated a lowering of the fat elimination capacity. All changes reverted to the original values after an 8-week wash-out period. The data suggest that the effects of acitretin on the lipoprotein metabolism resemble those of etretinate and isotretinoin.
Vahlquist
C
C
Department of Dermatology, University Hospital, Uppsala, Sweden.
Selinus
I
I
Vessby
B
B
D017255:Acitretin; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005217:Fat Emulsions, Intravenous; D005260:Female; D005533:Foot Dermatoses / Q000097:blood* / Q000188:drug therapy; D006229:Hand Dermatoses / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000097:blood* / Q000188:drug therapy; D014212:Tretinoin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001053:Apolipoproteins; D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008074:Lipoproteins; D014212:Tretinoin; D002784:Cholesterol; D017255:Acitretin