Monoamine-containing fiber plexuses in the spinal cord of guinea pigs during paralysis, recovery and relapse stages of chronic relapsing experimental allergic encephalomyelitis.
Immunohistochemical techniques were used to examine the morphology and distribution of monoamine- and substance P-containing fibers in the spinal cords of guinea pigs in acute paralytic, remission and relapse stages of chronic relapsing experimental allergic encephalomyelitis. During the initial paralytic attack, focal regions of axonal distortion appeared in the white matter of the cervical and thoracic cord; and axon terminal depletion in the gray matter of the caudal spinal cord was pronounced. This neuropathology persisted throughout remission and was exacerbated during relapse of paralysis. These results suggest that axonal damage is an important component of the pathophysiology of this autoimmune disease.
White
S R
SR
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164.
Vyas
D
D
Bieger
D
D
Samathanam
G
G
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D010243:Paralysis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D012008:Recurrence; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism* / Q000473:pathology; D013373:Substance P / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D013373:Substance P; D014446:Tyrosine 3-Monooxygenase