Chlorinated phenols as metabolites of lindane. Evaluation of the degree of conjugation in rat urine.
After lindane was administered to rats in a single oral dose, the time profile of the degree of conjugation of the main phenolic metabolites was evaluated. In all urine samples 2,3-dichlorophenol, 2,4,5- and 2,4,6-trichlorophenol, and 2,3,5,6-tetrachlorophenol were constantly present. 2,3,5,6-Tetrachlorophenol and then 2,4,6-trichlorophenol were the prevalent metabolites in all cases. The degree of conjugation did not correlate with the dissociation constant of individual chlorinated phenols. Phenol conjugation declined with time after administration.
Baliková
M
M
Institute of Toxicology and Forensic Chemistry, Medical Faculty, Charles University, Prague, Czechoslovakia.
Kohlicek
J
J
Rybka
K
K
D000284:Administration, Oral; D000818:Animals; D002733:Chlorophenols / Q000378:metabolism / Q000652:urine*; D002849:Chromatography, Gas / Q000379:methods; D004563:Electrochemistry; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002733:Chlorophenols; D001556:Hexachlorocyclohexane