[Effect of ruthenium red on the sodium channel inactivation of neuroblastoma cells].
Currents through sodium channels in the neuroblastoma cell membrane were measured after internal and external application of the ruthenium red. The treatment of the membrane by the dye resulted in a slowdown of inactivation kinetics of sodium currents and in the changes of activation and inactivation stationary parameters, which were more pronounced after internal application of the ruthenium red.
Nosyreva
E D
ED
Grishchenko
I I
II
Neguliaev
Iu A
IuA
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma / Q000503:physiopathology*; D012428:Ruthenium / Q000494:pharmacology*; D012430:Ruthenium Red / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors; D014407:Tumor Cells, Cultured
D007473:Ion Channels; D012430:Ruthenium Red; D012428:Ruthenium; D012964:Sodium
Vliianie rutenievogo krasnogo na inaktivatsiiu natrievykh kanalov kletok neĭroblastomy.