title: Cisplatin and intravenous continuous infusion of bleomycin in advanced and metastatic esophageal cancer.
abstract: Thirty-four patients with locally advanced or metastatic esophageal cancer were treated with cisplatin 35 mg/m2/day x 3 days in bolus, plus bleomycin 15 mg/day x 3 days, as an 18 h infusion, every 21-28 days. Twenty-nine are evaluable for response. Objective response was seen in 15 (52%, 95% confidence limits 35-69%) patients. Toxicity was mild. Twelve patients with locoregional disease were treated with this combination followed by radiotherapy and three of them are alive without disease at 18, 22 and 36 months. This combination warrants further study in the setting of combined treatment.
authors: Oncology Department, Hospital Sta. Creu i S. Pau, Barcelona, Spain.
authors: E
authors: E
authors: Marcuello
authors: E
authors: E
authors: Alba
authors: G
authors: G
authors: Gómez de Segura
authors: M
authors: M
authors: Sánchez Parra
authors: L
authors: L
authors: de Andrés
authors: A
authors: A
authors: López Pousa
authors: C
authors: C
authors: Pallares
authors: J R
authors: JR
authors: Germá
authors: J J
authors: JJ
authors: López López
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D001761:Bleomycin; D002945:Cisplatin