Modification of neuronal cell adhesion affects the genetic expression of the A4 amyloid peptide precursor.
Heparan sulfate proteoglycans play a key role in neuronal cell adhesion and their core protein share amino acid sequence with the A4 amyloid peptide precursor. Modification of neuronal cell adhesion by heparin induces important morphological changes in rat cultured neurones and increases the genetic expression of the A4 amyloid peptide precursor.
Octave
J N
JN
Université Catholique de Louvain, Laboratoire de Neurochimie, Bruxelles, Belgium.
de Sauvage
F
F
Maloteaux
J M
JM
D000682:Amyloid / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D011498:Protein Precursors; D012313:RNA; D006493:Heparin