[Kidney transplant rejection and the original kidney disease of the recipient].
Glomerulonephritis, pyelonephritis, diabetic nephropathy, and polycystic kidney disease were the four most frequent original renal diseases leading to altogether 500 kidney transplantations in Rostock from 1976 to 1989. A total of 457 pathomorphological specimen (255 transplant biopsies, 159 explants, 43 postmortem grafts) of 348 renal transplants was histologically studied. The most striking findings were a more frequent hyperacute rejection and an earlier loss of explants as well as a higher incidence of relevant vascular rejection in graft biopsies of glomerulonephritis versus pyelonephritis patients. The obtained results suggest a possible disposition of recipients with glomerulonephritis to a more rapid and intense graft rejection in comparison to transplant patients with pyelonephritis as underlying renal disease.
Nizze
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Brockmöller
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D005858:Germany; D005921:Glomerulonephritis / Q000473:pathology; D006084:Graft Rejection; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D011704:Pyelonephritis / Q000473:pathology
Transplantatnierenrejektion und renales Grundleiden des Empfängers.