Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.
A set of cDNA clones coding for alkali myosin light chains (AMLC) was isolated from fetal human skeletal muscle. Nucleotide sequence analysis and RNA expression patterns of individual clones revealed related sequences corresponding to (i) fast fiber type MLC1 and MLC3; (ii) the embryonic MLC that is also expressed in fetal ventricle and adult atrium (MLCemb); and (iii) a nonsarcomeric MLC isoform that is found in all nonmuscle cell types and smooth muscle. The AMLC gene family in man comprises unique copies for MLC1, MLC3 and MLCemb, and multiple copies for the nonsarcomeric MLC genes. The gene coding for MLC1 and MLC3 is located on human chromosome 2.
Seidel
U
U
Department of Toxicology, Medical School, University of Hamburg, F.R.G.
Bober
E
E
Winter
B
B
Lenz
S
S
Lohse
P
P
Goedde
H W
HW
Grzeschik
K H
KH
Arnold
H H
HH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA; D005333:Fetus; D006321:Heart / Q000196:embryology; D006801:Humans; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000378:metabolism; D009132:Muscles / Q000196:embryology / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D015879:Myosin Subfragments; D009218:Myosins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010446:Peptide Fragments / Q000235:genetics*; D012313:RNA; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D015879:Myosin Subfragments; D010446:Peptide Fragments; D012313:RNA; D004247:DNA; D009218:Myosins