title: Specificity of chimpanzee antibodies binding a strain-specific HIV-1 neutralization epitope of the external envelope.
abstract: Sera from three chimpanzees infected with a primary lymphadenopathy-associated virus (LAV-1) or human T-lymphotropic virus type III (HTLV-IIIB) passage, from two chimpanzees infected with blood from the primary infected chimpanzees, and from one chimpanzee infected with blood from a secondary passage animal all bound the peptides 3B and 3B/RF, sharing the sequence IQRGPGR, with equally high titers. Pepscan analysis confirmed the amino acids Q, R, G, P, and G as irreplaceable in order to retain antigenicity.
authors: Human Retrovirus Laboratory, Academic Medical Center, Amsterdam, The Netherlands.
authors: J
authors: J
authors: Goudsmit
authors: M
authors: M
authors: Bakker
authors: L
authors: L
authors: Smit
authors: R H
authors: RH
authors: Meloen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000595:Amino Acid Sequence; D000818:Animals; D000918:Antibody Specificity; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology*
chemical_list: D000939:Epitopes; D015483:HIV Antibodies; D010446:Peptide Fragments