title: Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.
abstract: cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.
authors: Cold Spring Harbor Laboratory, New York 11724.
authors: G
authors: G
authors: Draetta
authors: H
authors: H
authors: Piwnica-Worms
authors: D
authors: D
authors: Morrison
authors: B
authors: B
authors: Druker
authors: T
authors: T
authors: Roberts
authors: D
authors: D
authors: Beach
mesh_terms: D016203:CDC2 Protein Kinase; D002453:Cell Cycle; D006367:HeLa Cells; D008938:Mitosis; D010750:Phosphoproteins / Q000378:metabolism*; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src); D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D019000:Phosphotyrosine; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src); D016203:CDC2 Protein Kinase