The same external signal differentially induced the c-myc expression in Burkitt lymphoma and B-lymphoblastoid cell lines.
An extracellular signal, such as phorbol-12-myristate-13-acetate (PMA), was found to reduce the c-myc expression in Burkitt lymphoma (BL) cells but augment the expression of the same gene in a B-lymphoblastoid cell line (B-LCL). Studies with Epstein-Barr virus (EBV)-converted BL cells demonstrated that the differential effect of PMA on c-myc expression was not due to alterations in the structure of the translocated c-myc gene, but to the difference in the intracellular milieu of the B cells. Experiments on the degradation rate in c-myc RNA suggested that this phenomenon in c-myc expression was exerted, at least in part, at the transcriptional level.
Numoto
M
M
Department of Pathology, Hiroshima University, Japan.
D001402:B-Lymphocytes / Q000187:drug effects*; D002051:Burkitt Lymphoma / Q000235:genetics*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D004854:Herpesvirus 4, Human; D006801:Humans; D009857:Oncogenes / Q000187:drug effects*; D012313:RNA / Q000032:analysis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014178:Translocation, Genetic
D012313:RNA; D013755:Tetradecanoylphorbol Acetate