High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat.
High dose methylprednisolone (50 mg kg-1, daily) was administered to Lewis rats with experimental allergic neuritis from onset of the disease. Disease severity was reduced and recovery was significantly more rapid than that in saline-injected controls. Histological examination showed reduction of endoneurial edema, cellular infiltration, and demyelination. The results provide experimental evidence supporting the trial of high dose steroids in human demyelinating polyradiculoneuropathy.
Watts
P M
PM
Department of Neurology, United Medical and Dental Schools, Guy's Hospital, London, United Kingdom.
Taylor
W A
WA
Hughes
R A
RA
D000818:Animals; D000906:Antibodies / Q000032:analysis; D005727:Ganglia, Spinal / Q000473:pathology; D007114:Immunization; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D004676:Myelin Basic Protein / Q000276:immunology; D018996:Myelin P2 Protein; D009420:Nervous System / Q000473:pathology; D009422:Nervous System Diseases / Q000276:immunology; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011917:Rats, Inbred Lew
D000906:Antibodies; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D008775:Methylprednisolone