Interleukin 1.
The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines. Initial studies focused on interleukin 1-like molecules produced by keratinocytes, initially termed epidermal cell-derived thymocyte activating factor (ETAF). It is now clear that the functional activities described by the term ETAF are composed mainly of interleukin 1 alpha and interleukin 1 beta, although other epidermal cytokines may contribute to the biologic activity. The biologic properties of interleukin 1 are the basis of this review.
Sauder
D N
DN
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
D000818:Animals; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism / Q000502:physiology; D007633:Keratins; D008214:Lymphocytes / Q000276:immunology; D015394:Molecular Structure; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007633:Keratins