Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization.
Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicit not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.
Giulian
D
D
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Woodward
J
J
Young
D G
DG
Krebs
J F
JF
Lachman
L B
LB
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000502:physiology*; D002452:Cell Count; D002560:Cerebrovascular Circulation; D005260:Female; D005911:Gliosis / Q000139:chemically induced* / Q000473:pathology; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D007267:Injections; D007375:Interleukin-1; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D007375:Interleukin-1; D005974:Glutamate-Ammonia Ligase