Synovial fluid lymphocytes in different subtypes of juvenile rheumatoid arthritis.
We studied the subsets of synovial fluid (SF) lymphocytes and their activation states in 4 subtypes of juvenile rheumatoid arthritis. The expression of lymphocyte differentiation antigens and activation markers (Ia and Tac) appeared to be similar in these subgroups. Tac + DNA-synthesizing T blasts represented, at most, 5% of all SF mononuclear cells. This finding was in clear contrast to the high proportion of Ia-positive SF mononuclear cells. There were no differences in Ia and Tac expression or DNA synthesis among the different juvenile rheumatoid arthritis subgroups. This finding suggests that the cell-mediated immune response may represent secondary features of the disease that are involved as a final common pathogenetic pathway.
Bergroth
V
V
Fourth Department of Medicine, University of Helsinki, Finland.
Konttinen
Y T
YT
Pelkonen
P
P
Haapala
M
M
Haapasaari
J
J
Nordström
D
D
Kunnamo
I
I
Friman
C
C
D001171:Arthritis, Juvenile / Q000145:classification / Q000473:pathology*; D000939:Epitopes; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D013582:Synovial Fluid / Q000166:cytology*
D000939:Epitopes