[Leukocyte filtration].
The adverse clinical potential of leucozytes in red cell and platelet transfusion became more widely recognized. Therefore, it is preferable to remove as many white cells as possible to avoid all these risks. The new filtration methods offer improved removal efficiency and leave a quantity of leucocytes that is below the threshold for induction of a febrile reaction in most sensitized patients and close to the threshold to avoidance of alloimmunization. A selective white cell removal from platelet concentrates using new filters, in which fibers were coated with a particular polymer, increases the efficiency of trapping white cells and also prevents platelet adhesion. These filters are capable of remove more than 95% of the leucocytes with minimal platelet loss, normal morphology and in vitro function. These filters can be used in bag-to-bag as well as in bedside filtration and greatly reduce the side effects caused by white cells in blood products.
Müller
N
N
Institut für Transfusionsmedizin, Universitätskliniken Münster, BRD.
D001803:Blood Transfusion / Q000379:methods*; D017707:Erythrocyte Transfusion; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007958:Leukocyte Count
Leukozyten-Filtration.