title: [Changes in the axonal protein transport under conditions of elevated functional activity of the neurons].
abstract: The prolonged nonintensive physical activity by swimming without load (12 +/- 2 h.) has no effect on the overall amount of fast and slow transported proteins of transport velocity in rat central and peripheral sensory fibres of the sciatic nerve. However, the rate of fast axonal transport in the motor fibres decreases by 18% and the amount of proteins by a factor of 2 as compared with control. The rate of slow axonal transport does not change, but the mean level of transported labeled proteins decreases by 1.9 times. The relatively short-term but more intensive activity (swimming with the load during 60 +/- 10 min.) provokes an increase of the rate by 10% and the overall amount of fast transported proteins by 2 times. The rest of the animals during 6 h. returns the above parameters to control values. A suggestion is made that the rate and the amount of transported proteins depend on the variations in functional state of the neurons and their axons.
authors: A G
authors: AG
authors: Mustafin
authors: V N
authors: VN
authors: Iarygin
authors: S A
authors: SA
authors: Prokof'ev
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002250:Carbon Radioisotopes; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology*; D013550:Swimming
chemical_list: D002250:Carbon Radioisotopes; D009419:Nerve Tissue Proteins
vernacular_title: Izmeneniia aksonal'nogo transporta belkov v usloviiakh povyshennoĭ funktsional'noĭ aktivnosti neĭronov.