[Function and morphology of intraperitoneal segmental pancreas allotransplants with cyclosporin monotherapy in the dog--a comparison of 4 drainage procedures of exocrine secretions].
Dogs which had received cyclosporine A for immunosuppression were investigated to elucidate functionality and morphological alterations in pancreas allografts, with enteral, vesical, peritoneal or occluded exocrine drainage. None of the animals with enteral drainage survived the first four postoperative weeks, with lethal infections being responsible for allograft failure. Full functionality three months from transplantation was recorded from three of seven transplants with ductal occlusion and unobstructed drainage into the abdominal cavity. Ductal occlusion was repeatedly accompanied by pancreatitis and pseudo-cysts. Fibrotisation of the organ and loss of endocrine islets of pancreas were recordable from these cases just as from grafts with unobstructed drainage into the abdominal cavity. Drainage of exocrine secretion into the bladder yielded good success in one of seven animals and was morphologically and functionally characterised primarily by occlusive metaplastic ossification along the transition to the anastomosis.
Rosenberger
J
J
Chirurgischen Universitätsklinik Köln-Lindenthal.
Hesse
U J
UJ
Holland
M
M
Arnold
G
G
Hübinger
A
A
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage; D003524:Cyclosporins / Q000008:administration & dosage*; D003973:Diatrizoate; D004285:Dogs; D004322:Drainage / Q000379:methods*; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage; D005227:Fatty Acids; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D006084:Graft Rejection / Q000187:drug effects; D007328:Insulin / Q000097:blood; D007583:Jejunum / Q000601:surgery; D008297:Male; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation; D010189:Pancreatic Juice / Q000378:metabolism*; D011409:Propylene Glycols; D011506:Proteins / Q000008:administration & dosage; D013536:Suture Techniques; D013917:Thrombin / Q000008:administration & dosage; D001743:Urinary Bladder / Q000601:surgery; D015028:Zein
D003524:Cyclosporins; D004338:Drug Combinations; D005227:Fatty Acids; D015718:Fibrin Tissue Adhesive; D007328:Insulin; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D005340:Fibrinogen; D015028:Zein; D005176:Factor XIII; D007611:Aprotinin; C020481:alcoholic prolamine solution; D013917:Thrombin
Funktion und Morphologie intraperitonealer segmentaler Pankreasallotransplantate unter Cyclosporin-Monotherapie beim Hund--Vergleich von 4 Verfahren zur Drainage der exokrinen Sekretion.