Interaction of citrate with Fe(III)-bleomycin.
1. Citrate binds to Fe(III)-bleomycin, removing the ferric ion from the iron-drug complex; a reaction that may be of physiological significance. 2. Low concentrations of citrate markedly enhance the rate of iron transfer from Fe(III)-bleomycin to apotransferrin; an iron binding plasma protein.
Løvstad
R A
RA
Institute of Medical Biochemistry, University of Oslo, Norway.
D000818:Animals; D001761:Bleomycin / Q000378:metabolism* / Q000031:analogs & derivatives; D002951:Citrates / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding
D002951:Citrates; C023503:iron bleomycin; D001761:Bleomycin