Histamine release by free radicals: the relationship with the signal transduction system.
In isolated rat serosal mast cells exposed to free radical-generating systems, the release of histamine was associated with a significant increase in malonyldialdehyde (MDA) production suggesting a relationship between histamine release and membrane lipid peroxidation. Under these circumstances, an increase in cytosolic calcium was observed, uncoupled with any stimulation of inositol phospholipid (PtdIns) breakdown. The data suggest similarities between the release of histamine induced by calcium ionophores and by free radical-generating systems.
Masini
E
E
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Giannella
E
E
Pistelli
A
A
Palmerani
B
B
Gambassi
F
F
Occupati
B
B
Mannaioni
P F
PF
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D005609:Free Radicals; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D015398:Signal Transduction / Q000187:drug effects; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D005609:Free Radicals; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D008315:Malondialdehyde