The effects of 4-pentenoic and pentanoic acids on the isolated rat atria.
The peak developed tension and the pacemaker frequency of the isolated atria from fed and fasted rats, declined progressively during the incubation in a glucose-free medium containing 2-deoxyglucose. The atria from fed rats exhibited a faster decline than those from fasted rats, which was associated to a slower triacylglycerol lipolysis. 4-Pentenoic acid inhibited the lipolysis of both groups of atria but did not alter the atrial contractile performance. However, it enhanced the decline of the pacemaker frequency in the atria from fasted rats whereas, in contrast, it alleviated the decline in the fed atria. n-Pentanoic acid ameliorated the impairment of the contractile and pacemaker activities in both groups of atria, without affecting the lipolysis. It was concluded that, since the inhibition of the intramyocardial lipolysis did not correlate with changes of the atrial functions, 4-pentenoic acid was not appropriate to assess about the contribution of endogenous triacylglycerol to the maintenance of the atrial contractile and pacemaker activities.
Varela
A
A
Orientación Fisiología Humana, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
Felip
M N
MN
Montesi
A
A
Savino
E A
EA
D000818:Animals; D005215:Fasting; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D005260:Female; D006325:Heart Atria / Q000187:drug effects* / Q000378:metabolism; D006329:Heart Conduction System / Q000187:drug effects; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010421:Pentanoic Acids / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism; D014631:Valerates / Q000494:pharmacology*
D005229:Fatty Acids, Monounsaturated; D010421:Pentanoic Acids; D014280:Triglycerides; D014631:Valerates; C009785:4-pentenoic acid