Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients.
Human peripheral blood mononuclear cells and T-cell lines and clones from individuals immunized with rabies PM vaccine were tested for the ability to recognize antigenic determinants in rabies and rabies-related viruses in an antigen-induced proliferation assay. Some, but not all, of the T cells from these individuals cross-reacted with various laboratory strains of rabies virus with rabies-related viruses such as Duvenhage and Mokola. In addition, these T cells were shown to react with epitopes of either the ribonucleoprotein or the viral glycoprotein. Rabies-specific cytotoxic T-cell responses by a CD4+ T-cell line were evident against antigenic determinants of the ribonucleoprotein and glycoprotein.
Celis
E
E
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
Ou
D
D
Dietzschold
B
B
Koprowski
H
H
D000914:Antibodies, Viral / Q000096:biosynthesis; D002455:Cell Division; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D012209:Rhabdoviridae / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D011819:Rabies Vaccines