title: [Interaction of anemone toxin BgTX8 with the ion channels of isolated mammalian neurons].
abstract: Interaction between anemone toxin BgTX8 and sodium channels in isolated single neurons of rat sensory ganglia was studied by voltage-clamp and intracellular perfusion techniques. It was shown that BgTX8 in external and internal solutions induced a dose-dependent slowdown of inactivation kinetics. Dissociation constant for receptor-toxin complex was found to be 4.10(-6) mol/l.
authors: A E
authors: AE
authors: Valeev
authors: A N
authors: AN
authors: Dashkin
authors: A G
authors: AG
authors: Fleites
authors: L F
authors: LF
authors: Alcorta
authors: R
authors: R
authors: Mas
mesh_terms: D000818:Animals; D003064:Cnidarian Venoms / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism
chemical_list: D003064:Cnidarian Venoms; D007473:Ion Channels; C056274:anemone toxin BgTX8 (Bunodosoma granolifera); D012964:Sodium; D011188:Potassium
vernacular_title: Vzaimodeĭstvie anemonotoksina BgTX8 s ionnymi kanalami izolirovannykh neĭronov mlekopitaiushchikh.