In vitro anti-HIV-1 activity of chondroitin polysulphate.
Three chondroitin sulphates and five chondroitin polysulphates, with molecular weights ranging from 3000 to 30,000 daltons, were evaluated applying the MT-4 cell-culture assay for inhibition of HIV-1 replication. These results were compared with those obtained with compounds of known in vitro antiretroviral activity, namely, dermatan sulphate, heparin, dextran sulphate, pentosan polysulphate, zidovudine (AZT) and suramin. Chondroitin polysulphate with a molecular weight (MW) of 9000 daltons (CPS 9000) was the most effective polyanionic compound studied. In contrast with zidovudine, this CPS 9000 was not toxic for MT-4 cells up to a concentration of 500 micrograms/ml. Moreover, CPS 9000 is highly specific for inhibition of HIV-1 reverse transcriptase.
Jurkiewicz
E
E
Deutsches Primatenzentrum, Göttingen, FRG.
Panse
P
P
Jentsch
K D
KD
Hartmann
H
H
Hunsmann
G
G
D002478:Cells, Cultured; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D006801:Humans; D008970:Molecular Weight; D018894:Reverse Transcriptase Inhibitors
D018894:Reverse Transcriptase Inhibitors; D002807:Chondroitin; D002809:Chondroitin Sulfates