title: [Intra-arterial chemotherapy with methotrexate and 5-fluorouracil in extensive locoregional recurrences of cervix cancer].
abstract: The significance of intra-arterial cytostatic drug infusion in connection with histologically confirmed recurrences of squamous carcinomas was investigated within a clinical controlled trial between 1978 and 1985. Patients selection according to strict precaution in consideration of the factors influencing prognosis. After clinical examination, computer-tomographic, sono- and angiographic staging ten patients received MTX and 5FU i.a., completed by intra-venous CMFV-treatment in cases with objective remission of disease (therapy arm A). Six women received FACV-combination only systemically (therapy arm B). One partial (PR) and fife moderate remissions (MR) were achieved by intra-arterial chemotherapy in early time. The median duration of survival was 7.5 month for patients in therapy arm A. Significant prolongation of cumulative survival time (p less than 0.05) was determined only by remission of disease in patients with grade performance status 0-1 WHO. Intra-arterial chemotherapy showed lower toxicity versus systemic FACV- or CMFV-treatment. No complications of using prolonged i.a. infusion by Seldinger's technique were encountered. Further studies for within interdisciplinary scientific research in more chemosensitive malignancies of the female genital tract are warranted.
authors: Klinik für Gynäkologie, Medizinischen Akademie, Carl Gustav Carus Dresden.
authors: U
authors: U
authors: Dziambor
authors: B
authors: B
authors: Sarembe
authors: P
authors: P
authors: Richter
authors: W
authors: W
authors: Lotze
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010166:Palliative Care; D011446:Prospective Studies; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Intraarterielle Chemotherapie mit Methotrexat und 5-Fluorourazil bei ausgedehnten loco-regionalen Rezidiven des Zervixkarzinoms.