title: [Results (in vitro and in vivo) of cryopreservation of human thrombocytes with glycerol].
abstract: The cryopreservation of human platelets was carried out with a final glycerol concentration of 0.38-0.48 mol/l (3.5-4.5%). The in-vitro-recovery (total platelets, aggregation, 14C-5-HT-uptake, clot retraction, total ATP, morphology) was in the range of 35-93% in comparison with freshly prepared platelet concentrates. The platelet survival was investigated by 51chrom labeling and autologous transfusion. A survival rate of 42% and a mean survival of 79% in comparison with freshly prepared platelets is concentrates are the results. In spite of reduced viability the cryopreservation of platelets is invaluable for providing compatible platelets for alloimmunized patients.
authors: Bezirksinstitut für Blutspende- und Transfusionswesen, Berlin.
authors: G
authors: G
authors: Zapff
authors: I
authors: I
authors: Scheibe
authors: W
authors: W
authors: Toursel
authors: D
authors: D
authors: Dekowski
authors: H
authors: H
authors: Richter
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion; D002470:Cell Survival / Q000187:drug effects; D005615:Freezing; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D017713:Platelet Transfusion
chemical_list: D005990:Glycerol
vernacular_title: Ergebnisse (in vitro und in vivo) der Kryokonservierung von Human-Thrombozyten mit Glycerol.