title: Histamine secretion from mast cells stimulated with somatostatin.
abstract: Histamine release from isolated mast cells stimulated with somatostatin resembled that induced by other basic agents. The process was rapid, independent of added calcium or phospholipids, non-cytotoxic, species and tissue specific, not mediated through cell-fixed antibodies or glucoreceptors, and inhibited by antagonists of the polyamine receptor. Somatostatin and other polycations may then act through a common receptor or binding site on the mast cell membrane.
authors: Department of Chemistry, University College London, UK.
authors: T A
authors: TA
authors: Kassessinoff
authors: F L
authors: FL
authors: Pearce
mesh_terms: D000818:Animals; D006224:Cricetinae; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
chemical_list: D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; D013004:Somatostatin