title: Alpha interferon treatment of chronic non-A, non-B hepatitis caused by intravenous gammaglobulin.
abstract: Two patients with hypogammaglobulinemia and chronic active non-A, non-B hepatitis caused by intravenous gammaglobulin substitution were treated long-term with alpha-2b interferon (Introna). Both achieved normal aminotransferase levels within 2-12 weeks after initiation of interferon therapy. One patient was rebiopsied after 6 months of therapy and showed some degree of improvement in the liver inflammatory activity. The beneficial effects warrant a randomized controlled study.
authors: Department of Infectious Diseases, Karolinska Institute, Roslagstull Hospital, Stockholm, Sweden.
authors: R
authors: R
authors: Schvarcz
authors: O
authors: O
authors: Weiland
authors: H
authors: H
authors: Glaumann
mesh_terms: D000368:Aged; D005260:Female; D006526:Hepatitis C / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006525:Hepatitis, Viral, Human / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D007370:Interferon Type I; D005719:gamma-Globulins