Neuropeptide Y blocks a calcium current in C cells of bullfrog sympathetic ganglia.
The effects of neuropeptide Y (NPY) on the Ca2+ current of enzymatically dispersed neuronal somata from bullfrog paravertebral sympathetic ganglia were investigated using the patch-clamp technique. In C neurons, NPY induced a concentration-dependent decrease in the amplitude of the Ca2+ current and induced a slow biphasic current rising phase. Upon removal of NPY these parameters returned to near control values. NPY had no discernable effect on the Ca2+ current recorded in B neurons.
Schofield
G G
GG
Section of Electrophysiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
Ikeda
S R
SR
D000818:Animals; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects*; D009478:Neuropeptide Y / Q000494:pharmacology*; D011892:Rana catesbeiana
D007473:Ion Channels; D009478:Neuropeptide Y