[The histamine-liberating action of polymyxin B and its analogs].
Histamine-releasing effect of polymyxin B1 and its deacylated analogues has been studied on purified rat mast cells. The structure-activity analysis showed that cyclic peptide fragment and acyl residue of molecule of polymyxin plays an important role in histamine-releasing activity. Histamine release, induced by polymyxin B1 and its analogue was blocked by metabolic inhibitor antimycin A. Preincubation of polymyxin B1 with lipopolysaccharide inhibits in dose-dependent manner polymyxin-induced histamine secretion from rat mast cells.
Bairamashvili
D I
DI
Voĭtenko
V G
VG
Gushchin
I S
IS
Zinchenko
A A
AA
Miroshnikov
A I
AI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000032:analysis; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D011113:Polymyxins; D006632:Histamine; D011112:Polymyxin B
Gistaminvysvobozhdaiushchee deĭstvie polimiksina B i ego analogov.