[Effect of kininotropic preparations on ulcer formation in rats].
The effects of an inhibitor of kininogenesis trasylol, its activator, cellulose sulfate, and inhibitors of kininases, captopril and D-penicillamine, as well as an antagonist of kinins, parmidine, on the development of the rat ulcers induced by histamine, absolute ethanol, reserpine and diclofenac sodium were studied. It was found that the drugs influencing metabolism and effects of kinins (except trasylol) exert differently pronounced antiulcer effects during modelling gastric ulcers by administering ethanol, reserpine and diclofenac sodium. At the same time they were inactive on the model of histamine-induced ulcers in rats.
Faermerk
I F
IF
Shvarts
G Ia
GIa
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D004008:Diclofenac / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000633:toxicity; D006632:Histamine / Q000633:toxicity; D007705:Kinins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011727:Pyridinolcarbamate / Q000627:therapeutic use; D051381:Rats; D012110:Reserpine / Q000633:toxicity; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D007705:Kinins; D004008:Diclofenac; D000431:Ethanol; D011727:Pyridinolcarbamate; D006632:Histamine; D012110:Reserpine; D002482:Cellulose; C020254:cellulose sulfate; D007611:Aprotinin; D002216:Captopril; D010396:Penicillamine
Vliianie kininotropnykh preparatov na iazvoobrazovanie krys.