[Effectiveness of intratracheal administration of contrykal in combined treatment of children with intrathoracic tuberculosis complicated by endobronchial pathology].
Local balance in the system of proteinases-inhibitors in bronchial secretion was studied in 97 children with intrathoracic tuberculosis involving the bronchial tree by activity of trypsin-like proteinases (TLP), free antitryptic activity (ATA) and total content of locally synthesized low molecular acid resisting proteinase inhibitors (ARI). In the children with endobronchial pathology there was observed imbalance in the system evident from increasing activity of TLP and simultaneous decreasing of ATA and the content of ARI. The maximum inhibition of ARI local secretion and increasing of the TLP activity were stated in the patients with purulent and specific endobronchitis. In the children with catarrhal endobronchitis the shifts were moderate. Local use of contrykal in the form of ultrasonic inhalations in complex therapy of tuberculosis promoted in short periods reduction of the inhibitory potential, a 2-fold decrease in the terms of clinical recovery from endobronchitis and a decrease in the frequency of marked fibrous lesions in the bronchi and lungs as compared to analogous patients in the control group treated without the use of the proteinase inhibitor.
Klevno
N I
NI
Kaminskaia
G O
GO
Kagalovskiĭ
G M
GM
D000293:Adolescent; D007611:Aprotinin / Q000008:administration & dosage*; D001991:Bronchitis / Q000150:complications* / Q000188:drug therapy / Q000201:enzymology; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007223:Infant; D011480:Protease Inhibitors / Q000378:metabolism; D014132:Trachea; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy* / Q000201:enzymology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology
D011480:Protease Inhibitors; D007611:Aprotinin; D010450:Endopeptidases
Effektivnost' intratrakheal'nogo vvedeniia kontrikala v kompleksnom lechenii deteĭ s vnutrigrudnym tuberkulezom, oslozhnennym éndobronkhial'noĭ patologieĭ.