Evidence that C4b-binding protein is an acute phase protein.
C4b-binding protein is a regulatory factor for both complement and coagulation systems. We found that a human hepatoma cell line, Hep G2, was capable of synthesizing C4b-binding protein and that the secretion of C4b-binding protein was enhanced by interleukin-6 and tumor necrosis factor, which are known to be modulators of acute phase proteins. In addition, the plasma content of C4b-binding protein was found to increase in patients of acute pneumonia. These results suggest that C4b-binding protein is an acute phase protein.
Saeki
T
T
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University, Sapporo, Japan.
Hirose
S
S
Nukatsuka
M
M
Kusunoki
Y
Y
Nagasawa
S
S
D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000328:Adult; D006528:Carcinoma, Hepatocellular; D002352:Carrier Proteins / Q000096:biosynthesis*; D002460:Cell Line; D002648:Child; D015935:Complement C4b / Q000378:metabolism*; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D008113:Liver Neoplasms; D011014:Pneumonia / Q000097:blood; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D007375:Interleukin-1; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D015935:Complement C4b