Cytokines involved in the generation of cytolytic effector T lymphocytes.
The differentiation of precursor, antigen-competent, T cells into effective helper and/or cytolytic cells involves a number of different steps that are signaled by soluble molecules termed cytokines. We demonstrate here that subsets of T cells, distinguished on the basis of their expression of cell-surface markers, CD4 and CD8, receive distinct signals for differentiation. The precursor T cells of a T-cell subset that is MHC class II-restricted are readily activated by signals provided by rIL-1, rIL-2, rIL-3, or IFN-gamma. The precursor T cells of the MHC class I-restricted T-cell subset, on the other hand, are not readily activated by signals provided by rIL-1, rIL-3, or IFN-gamma. Recombinant IL-2 apparently functions in a nonrestricted manner, in that it can provide growth signals to both MHC class I- and class II-restricted T cells.
Plate
J M
JM
Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Lukaszewska
T L
TL
Bustamante
G
G
Hayes
R L
RL
D000818:Animals; D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000502:physiology*; D007375:Interleukin-1 / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007377:Interleukin-3 / Q000494:pharmacology; D007378:Interleukins / Q000502:physiology*; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1; D007376:Interleukin-2; D007377:Interleukin-3; D007378:Interleukins; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007372:Interferons