title: Inhibition of platelet activation by 2-mercaptopropionylglycin in vitro and in vivo.
abstract: 2-mercaptopropionylglycin (2-MPG), a cell membrane penetrating thiol, was evaluated for its antithrombotic potential using in vitro and in vivo tests. 2-MPG was found to inhibit agonist-induced platelet aggregation and serotonin release as well as prostaglandin/thromboxane synthesis in platelet-rich plasma. Administration of 2-MPG to rats resulted in an inhibition of laser-induced thrombus formation in mesenteric vessels. When plasma was incubated with 2-MPG and then used for determination of various standard coagulation parameters, significant prolongation of the clotting times were observed.
authors: Institute of Pathological Biochemistry, Medical Academy of Erfurt, GDR.
authors: W
authors: W
authors: Loesche
authors: K
authors: K
authors: Breddin
authors: G P
authors: GP
authors: Pescarmona
authors: A
authors: A
authors: Bosia
authors: P
authors: P
authors: Spangenberg
authors: E
authors: E
authors: Michel
authors: U
authors: U
authors: Till
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000378:metabolism; D013927:Thrombosis / Q000517:prevention & control; D008625:Tiopronin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001095:Arachidonic Acids; D016718:Arachidonic Acid; D012701:Serotonin; D008625:Tiopronin