[Antibody adsorption to tetrodotoxin-sensitive cytoplasmic proteins by murine neuroblastoma cells].
The study was aimed to examine properties of polyclonal antibodies elicited after immunization by cytoplasmic nerve cell glycoproteins forming sodium channels in liposomes. It was shown that intact murine neuroblastoma cells can absorb these antibodies. Absorbing cell dose-effect curves were found to have a characteristic form able to shift when the cell culture time or serum concentration in the growth medium varied.
Pinchuk
G V
GV
Pinchuk
L N
LN
Gerasimenko
O V
OV
D000327:Adsorption; D000818:Animals; D000912:Antibodies, Neoplasm / Q000502:physiology*; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D007114:Immunization; D007473:Ion Channels / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism; D051379:Mice; D024101:Mitochondrial Proteins; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009447:Neuroblastoma / Q000276:immunology / Q000378:metabolism*; D011485:Protein Binding; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin; D014407:Tumor Cells, Cultured
D000912:Antibodies, Neoplasm; D000939:Epitopes; D006023:Glycoproteins; D007473:Ion Channels; D008081:Liposomes; D024101:Mitochondrial Proteins; D009363:Neoplasm Proteins; C031044:insulin-dependent cytoplasmic regulator protein, rat; D013779:Tetrodotoxin; D012964:Sodium
Adsorbtsiia antitel k tsitoplazmaticheskim tetrodotoksinchuvstvitel'nym belkam kletkami myshinoĭ neĭroblastomy.