title: Genotoxic effect of benzene hexachloride in cultured human lymphocytes.
abstract: Chromosomal aberrations, sister chromatid exchanges, mitotic index and cell kinetics were observed in human peripheral lymphocytes after treatment with four different concentrations (0.0125, 0.025, 0.05 and 0.1 microgram/ml) of benzene hexachloride (BHC), an organochlorine pesticide. Cells were treated with BHC for 24, 48 and 72 h. There was a dose-dependent increase in the frequency of chromosomal aberrations and sister chromatid exchanges. A significant decrease in mitotic index was observed at all concentrations and times of exposure. BHC did not show a significant effect on cell kinetics.
authors: Institute of Genetics, Osmania University, Hyderabad, India.
authors: D S
authors: DS
authors: Rupa
authors: P P
authors: PP
authors: Reddy
authors: O S
authors: OS
authors: Reddi
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D009153:Mutagens; D001556:Hexachlorocyclohexane