title: Evidence for a myotropic effect of substance P in Periplaneta americana L.
abstract: It is shown that the isolated oviduct as well as the proctodeum of the cockroach Periplaneta americana are sensitive to substance P application. In contrast, the hyperneural muscle and the dilator muscle of the antennal heart were insensitive to this neuropeptide. The entire substance P amino acid sequence is necessary for the effects. This provides evidence for a pharmacological effect of substance P in insects.
authors: Department of Animal Physiology, Friedrich-Schiller-University of Jena, German Democratic Republic.
authors: H
authors: H
authors: Penzlin
authors: I
authors: I
authors: Wieduwilt
authors: W
authors: W
authors: Hertel
mesh_terms: D000818:Animals; D003058:Cockroaches / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D010057:Oviducts / Q000187:drug effects; D010526:Periplaneta / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology* / Q000502:physiology; D014781:Viscera / Q000187:drug effects
chemical_list: D013373:Substance P