[Clinicopathological study of advanced cancers of the oral cavity and pharynx--evaluation of the effects of chemotherapy and radiotherapy].
Some advanced oral cavity and pharynx cancer patients in stage T3 or T4 have been found to be therapeutically uncontrollable even by combination radio-and chemotherapy. Therefore, after preoperative treatment, operations were performed which effected reduction and scaring of the tumor that mimicked healing. We then made step-serial sections from the excised materials and analyzed the invasive depth of the cancer cells and the efficiency of therapy three-dimensionally by mapping the distribution of the tumor cells in each section.
Koieke
S
S
Dept. of Otorhinorarygology, Shikoku Cancer Center Hospital.
Uno
K
K
Ogawa
T
T
Mandai
K
K
Doihara
H
H
Moriwaki
S
S
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008867:Microtomy / Q000379:methods; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D011379:Prognosis; D011879:Radiotherapy Dosage
D001761:Bleomycin; D002945:Cisplatin; D008727:Methotrexate