Relationship of the final alpha-keratin compositions in dyskeratoses to those along the normal keratinization pathway: aetiological and diagnostic significance.
The final alpha-keratin compositions attained in the outer horny layer of 16 dyskeratoses have been compared with the series of compositions which is produced during normal epidermal differentiation. In each case, the abnormal outer horny layer composition corresponded with that of normal basal, spinous, granular or inner horny cells, with, in some cases, the addition of alpha-keratins characteristic of hyperproliferating/regenerating keratinocytes. The results have implications for the aetiology of these diseases. In addition, the distinction between the alpha-keratin patterns in certain of the conditions was sufficiently clear to allow the use of the technique as a non-invasive aid to diagnosis.
Hunter
I
I
University of Glasgow, Department of Dermatology, U.K.
Skerrow
D
D
D004817:Epidermis / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis* / Q000096:biosynthesis; D007642:Keratosis / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged
D007633:Keratins