[Tumor necrosis factor (TNF) and pathology; its relationships with other cytokines].
Tumor necrosis factor (TNF) is a cytokine produced mainly by activated monocytes/macrophages. We review here data obtained in four experimental models analyzed in our laboratory: cerebral malaria, graft-versus-host disease, BCG infection, and bleomycin-induced pulmonary fibrosis. We have shown that the triggering of these pathological conditions requires activation of T lymphocytes and overproduction of TNF, since these syndromes are associated with increased production of TNF mRNA and can be prevented either by T-cell depletion or by in vivo administration of neutralizing anti-TNF antibodies. These observations suggest that TNF is a central mediator in various immunopathological conditions and thus widen the field of T-cell mediated pathology.
Grau
G E
GE
Département de pathologie, Université de Genève.
Lambert
P H
PH
Vassalli
P
P
Piguet
P F
PF
D000818:Animals; D001761:Bleomycin; D006086:Graft vs Host Disease / Q000276:immunology; D008213:Lymphocyte Activation; D008288:Malaria / Q000276:immunology; D051379:Mice; D009164:Mycobacterium Infections / Q000276:immunology; D009163:Mycobacterium bovis; D010962:Plasmodium berghei; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha; D001761:Bleomycin
Tumor necrosis factor (TNF) et pathologie; ses relations avec d'autres cytokines.