[Urinary proteins in patients with diabetes mellitus].
In the second morning urine of 51 patients with diabetes mellitus (type I/II) albumin, N-acetyl-beta-D-glucosaminidase (NAG), alpha 1-microglobulin (alpha 1-M/U), creatinine (reference parameter) as well as serum alpha 1-microglobulin and creatine were determined. Following an international expert recommendation, three groups were formed depending on albumin excretion: group 1: albumin less than 24 mg/g creatinine (normal range) group 2: albumin greater than 24 mg/g creatinine and less than 200 mg/g creatinine (so called microalbuminuria) group 3: albumin greater than 200 mg/g creatinine (manifest proteinuria) The urinary tubular parameters NAG and alpha 1-microglobulin were above normal range in 17 and 21% respectively in group 1. For group 2 the results were abnormal in 94 and 69% and for group 3 in 100% of patients. Albuminuria correlated with NAG activity, but not with alpha 1-microglobulin excretion. These results indicate, that measuring NAG and alpha 1-microglobulin as markers for tubular dysfunction can give additional diagnostic informations about type and degree of diabetic nephropathy.
Hofmann
W
W
Institut für Klinische Chemie, Städtisches Krankenhaus Bogenhausen, München.
Guder
W G
WG
D000118:Acetylglucosaminidase / Q000652:urine; D000419:Albuminuria / Q000175:diagnosis; D001798:Blood Proteins / Q000032:analysis*; D003404:Creatinine / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D011507:Proteinuria / Q000175:diagnosis* / Q000201:enzymology; D000511:alpha-Macroglobulins / Q000652:urine
D001798:Blood Proteins; D000511:alpha-Macroglobulins; D003404:Creatinine; D000118:Acetylglucosaminidase
Harnproteine bei Patienten mit Diabetes mellitus.