title: 24-hour noninvasive oscillometric blood pressure monitoring: evaluation of the antihypertensive circadian profile of nitrendipine.
abstract: The understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest available portable device equipped with an oscillometric blood pressure (BP) recorder (SpaceLabs 90202, weight 480 g) devoid of any electrode. A good antihypertensive effect throughout the day in 20 outpatients could be demonstrated. No significant change of BP could be found in early morning and wake-up period; HR was not significantly affected after 6 weeks of oral therapy.
authors: Klinikum Steglitz, Freie Universität Berlin, F.R.G.
authors: W
authors: W
authors: Meyer-Sabellek
authors: K L
authors: KL
authors: Schulte
authors: B
authors: B
authors: Streitberg
authors: R
authors: R
authors: Gotzen
authors: A
authors: A
authors: Distler
mesh_terms: D000328:Adult; D000368:Aged; D001795:Blood Pressure Determination; D002940:Circadian Rhythm; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009568:Nitrendipine / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D009568:Nitrendipine