Cord blood basophil releasability: a predictive marker for allergy?
Liberation of histamine and LTC4 by cord-blood basophils was measured in the newborn from healthy and atopic parents. The cord-blood basophils of the second classification produced more histamine than those from the first, after challenge with anti-IgE. Thus, a newborn from atopic parent(s) probably carries more fixed IgE on the basophils than a newborn from healthy parents and so the capacity of cord-blood basophils to liberate mediators may be a good marker of allergy.
Miadonna
A
A
Istituto di Clinica Medica II, Università di Milano, Italy.
Tedeschi
A
A
Leggieri
E
E
Motta
G
G
Fabbri
C
C
Lorini
M
M
Lucci
G
G
Froldi
M
M
Marini
A
A
Zanussi
C
C
D000328:Adult; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D005312:Fetal Blood / Q000276:immunology*; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis; D007231:Infant, Newborn; D013189:SRS-A / Q000096:biosynthesis
D013189:SRS-A; D007073:Immunoglobulin E