title: Central hemodynamic effects at rest and during exercise of acute and chronic treatment with nisoldipine in essential hypertension.
abstract: The acute and chronic hemodynamic effects of nisoldipine were studied in 19 patients (17 men, 2 women; mean age 43 years) with essential hypertension at rest supine and sitting and during steady state 100 W bicycle exercise. At rest supine, the first dose response (1 h) was reduction of intraarterial (IA) pressure (9%) and total peripheral vascular resistance (TPR; 19%) and rise in heart rate (HR; 9%) and cardiac output (CO; 12%). Thereafter, the effect leveled off: at 3 h, IA pressure, CO, and TPR were reduced 6%, 1%, and 4%, respectively. Similar results were seen at rest and during exercise. After 1 year treatment, the changes were more marked: at rest, IA pressure and TPR fell (16% and 20%, respectively) while stroke volume and CO rose slightly (4% and 6%, respectively). There was no reflex tachycardia. During 100 W exercise, IA pressure fell (14%) due to reduction both in TPR (7%) and CO (6%). Thus, at rest, nisoldipine lowers blood pressure by reduction of TPR both acutely and chronically. The initial rise in CO is lost after long-term therapy. During exercise, falls in both TPR and CO contribute to the hypotensive effect.
authors: Medical Department, Haukeland Hospital, Bergen, Norway.
authors: P
authors: P
authors: Omvik
authors: P
authors: P
authors: Lund-Johansen
authors: H
authors: H
authors: Haugland
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002302:Cardiac Output; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015737:Nisoldipine; D005082:Physical Exertion; D013997:Time Factors; D014655:Vascular Resistance
chemical_list: D002121:Calcium Channel Blockers; D015737:Nisoldipine; D009543:Nifedipine