Augmentation of rat liver regeneration by FK 506 compared with cyclosporin.
The immunosuppressive drug, FK 506, increased the regeneration response that follows 40% and 70% hepatectomy in rats. The effect was similar to that obtained with cyclosporin.
Francavilla
A
A
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania.
Barone
M
M
Todo
S
S
Zeng
Q
Q
Porter
K A
KA
Starzl
T E
TE
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D006498:Hepatectomy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D016559:Tacrolimus
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D004247:DNA; D016559:Tacrolimus