[Effect of water containing calcium and magnesium sulfates on the elimination of cholesterol in the rat].
In the rat, the activity of the thermal water of Capvern and of its ionic components on the modification of the flow rate and composition of hepatic bile has been investigated. Two groups of rats were selected: the first group received per os an overload of the thermal water during six weeks. At that time on empty stomach a great increase of biliary phospholipids was observed. An intraduodenal injection of the thermal water produced a significant and rapid increase of biliary flow rate and biliary cholesterol. the animals of the second group received through intraduodenal injections the thermal water or an anionic solution composed of calcium, of magnesium sulphate or of both salts at their concentration in the thermal water, respectively. We observed an increase in biliary flow rate and biliary calcium concentration in the rats receiving the solution of calcium sulphate only and an increase of choleresis in the rats receiving the thermal water only. These data suggest that the thermal water has a specific action on the metabolism of cholesterol in increasing its biliary elimination particularly through the calcium ion content of the water.
Toussaint
C
C
Laboratoire de Pharmacodynamie et Hydrologie, UER des Sciences Pharmaceutiques, Bordeaux.
Peuchant
E
E
Courtès
C
C
Jensen
R
R
Canellas
J
J
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002133:Calcium Sulfate / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D008900:Mineral Waters; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D008900:Mineral Waters; D010743:Phospholipids; D008278:Magnesium Sulfate; D002784:Cholesterol; D002133:Calcium Sulfate
Rôle d'une eau sulfatée calcique et magnésienne sur l'élimination du cholestérol chez le rat.