Nicotinamide enhances skin flap survival.
The effects of nicotinamide in an abdominal island pedicle skin flap were examined. A 7 x 7 cm island pedicle skin flap ligating the left inferior neurovascular pedicle was created on 50 male Sprague Dawley rats (250-275 grams) that were divided into five groups. Animals received either 0.6 cc of saline or doses of nicotinamide for 16 days (14 days preoperatively and 2 days postoperatively): 25 mg b.i.d., 50 mg b.i.d., 100 mg b.i.d. or 200 mg b.i.d. Forty-eight hours postoperatively each animal received 25 mg of Fluorescein via the tail vein. The area of necrosis was visualized and quantified and is presented as % survival. A one factor Fisher PLSD test was performed with a statistical significance of p less than 0.05 with the results as follows: saline 58.8%, 25 mg 68.6%, 50 mg 82%, 100 mg 80.8%, and 200 mg 86%. From this data it would appear that the angiogenic factor nicotinamide may increase random flap survival.
Collins
T M
TM
Department of Surgery, Temple University Hospital, Philadelphia, Pa. 19140.
Denish
A
A
Sheffield
J
J
Mitra
A
A
Stueber
K
K
Smith
Y R
YR
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D009389:Neovascularization, Pathologic; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects
D009536:Niacinamide