[Intra- and postoperative effect of various plasma substitutes on blood rheology and conjunctival oxygen partial pressure in microsurgical intervertebral disk operations].
In a prospective, randomized, controlled, parallel group study the effect of different infusion solutions (HES 200/0.5 10%, dextran 40 10% and electrolyte solution) during and after intervertebral disc microsurgery on blood fluidity and conjunctival partial oxygen pressure was measured. At the beginning of the operation all patients showed a reduction in conjunctival oxygen pressure - independent of the infusion solution. Both fluidity of blood and oxygen partial pressure changed according to the plasma substitute used. Thus after the administration of medium molecular weight hydroxyethyl starch an improvement in the fluidity of blood with a consecutive significant increase in the conjunctival oxygen pressure could be observed, whereas there was no increase after the administration of electrolyte solution and only a slight one (according to tendency) after infusion of dextran.
Simon
J
J
Institute für Anaesthesie, Universität des Saarlandes, Homburg, Saar.
Jung
F
F
Holbach
T
T
Castor
G
G
Jaksche
H
H
Kiesewetter
H
H
D000328:Adult; D001809:Blood Viscosity; D002986:Clinical Trials as Topic; D003228:Conjunctiva / Q000378:metabolism; D003911:Dextrans / Q000008:administration & dosage; D004573:Electrolytes / Q000008:administration & dosage; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010952:Plasma Substitutes / Q000008:administration & dosage*; D010974:Platelet Aggregation / Q000187:drug effects; D011897:Random Allocation
D003911:Dextrans; D004573:Electrolytes; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D010100:Oxygen
Intra- und postoperativer Einfluss verschiedener Plasmaersatzmittel auf die Fliessfähigkeit des Blutes und den konjunktivalen Sauerstoffpartialdruck bei Mikrobandscheibenoperationen.