A double-blind crossover comparison of amlodipine and placebo added to captopril in moderate to severe hypertension.
Amlodipine 10 mg once daily added to captopril 25 mg twice daily for 4 weeks in patients with moderate to severe hypertension significantly improved blood pressure control (by -18/-12 and -20/-12 mm Hg for supine and standing systolic/diastolic pressures respectively, p less than 0.001). Few side effects related to amlodipine were noted and none was serious.
Maclean
D
D
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland.
Mitchell
E T
ET
Wilcox
R G
RG
Walker
P
P
Tyler
H M
HM
D000293:Adolescent; D000328:Adult; D000368:Aged; D017311:Amlodipine; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011897:Random Allocation
D002121:Calcium Channel Blockers; D017311:Amlodipine; D002216:Captopril; D009543:Nifedipine