Depression associated with nifedipine-induced calcium channel blockade.
Four cases are reported in which substantial depression was associated with the use of the calcium channel blocker nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In each case, the depression resolved following discontinuation of nifedipine. Possible mechanisms by which nifedipine may influence affective states are discussed.
Hullett
F J
FJ
Department of Psychiatry, University of California, Irvine.
Potkin
S G
SG
Levy
A B
AB
Ciasca
R
R
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D003866:Depressive Disorder / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects* / Q000494:pharmacology; D009661:Nortriptyline / Q000627:therapeutic use
D007473:Ion Channels; D009661:Nortriptyline; D009543:Nifedipine