Serotonin-mediated behavior in rats chronically treated with (-) deprenyl.
(-) Deprenyl given in small (0.25 mg/kg) daily doses for 30 days to rats left the serotonin (5-HT) and the 5-hydroxyindoleacetic acid (5-HIAA) levels in the striatum unchanged. The postsynaptic 5-HT receptor responsiveness, as measured with 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT), remained also unaltered. In (-) deprenyl-treated rats the p-chloroamphetamine (PCA)-induced 5-HT syndrome was significantly increased and this enhancement of the PCA effect was not abolished by the reserpine-induced depletion of the 5-HT stores.
Gyarmati
S
S
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Timar
J
J
Knoll
B
B
Knoll
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism; D010133:p-Chloroamphetamine / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D010627:Phenethylamines; D012642:Selegiline; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010133:p-Chloroamphetamine; D012110:Reserpine