title: Ciliated ovarian adenocarcinoma cells in ascitic fluid cytology: report of a case with immunocytochemical features.
abstract: A case of ovarian serous adenocarcinoma presenting with ascitic fluid is reported. Cytology of the ascitic fluid showed the presence of cilia on most of malignant tumor cells. These tumor cells occurred singly; cilia usually appeared in unipolar locations. Immunocytochemical studies were performed on the ascitic fluid samples as well as tissue sections. CA19-9, CA125, CA50, and epithelial antigens were positive, while carcinoembryonic antigen was negative. The positive reactions were characteristic for cilia of the tumor cells. The findings also emphasize that positive reaction of these markers will usually exclude a noncommon epithelial tumor, but will not distinguish between benign and malignant ovarian tumors. Report of cilia-bearing tumor cells in ascitic fluid are few; no one, to the best of our knowledge, has previously documented the immunocytochemistry of these tumor cells.
authors: Department of Cytopathology, Saiseikai Shiga Hospital, Japan.
authors: T K
authors: TK
authors: Kobayashi
authors: S
authors: S
authors: Teraoka
authors: T
authors: T
authors: Tsujioka
authors: Y
authors: Y
authors: Yoshida
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001202:Ascitic Fluid / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002467:Cell Nucleus / Q000473:pathology; D002923:Cilia / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D008562:Membrane Glycoproteins; D018396:Mucin-1