The effect of kainic acid administration on the cytoplasmic RNA content of nucleus arcuatus neurons in mice.
A single intramuscular injection of kainic acid (12 micrograms/g body weight, dissolved in 0.1 ml of aqua pro injectione) was administered to adult, sexually mature, male mice. Control mice received equivalent amounts of aqua pro injectione only. Experimental animals were killed 24, 72, 120, and 192 h after the injection, and those of the control group simultaneously with the final experimental one. As determined cytophotometrically, in all the experimental groups a significant increase in the cytoplasmic RNA content of nucleus arcuatus neurons took place, this increase being highest 72 h after kainic acid treatment.
Lach
H
H
Srebro
Z
Z
Surowiak
J
J
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D003593:Cytoplasm / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D007273:Injections, Intramuscular; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009474:Neurons / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D012313:RNA / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D013053:Spectrophotometry
D012313:RNA; D007608:Kainic Acid