Rheumatoid arthritis and pregnancy.
Although some 70% of patients with rheumatoid arthritis remit during pregnancy, the mechanism for this is not known. A variety of mechanisms have been invoked but none appear to be sufficiently established as an explanation. The most likely explanation is that a factor, or factors, cause the inhibition of release of lymphokines which thereby have a suppressive effect on rheumatoid inflammation.
Nicholas
N S
NS
Rheumatology Unit, Guys Hospital, London.
Panayi
G S
GS
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D002352:Carrier Proteins; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000276:immunology; D004967:Estrogens / Q000276:immunology; D005260:Female; D000071816:Glycodelin; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000473:pathology; D011257:Pregnancy Proteins / Q000276:immunology; D011266:Pregnancy-Associated Plasma Protein-A / Q000276:immunology; D011374:Progesterone / Q000276:immunology; D011453:Prostaglandins / Q000276:immunology; D014327:Trophoblasts / Q000166:cytology; D000509:alpha-Fetoproteins / Q000276:immunology
D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; D004967:Estrogens; D000071816:Glycodelin; D047908:Intracellular Signaling Peptides and Proteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D011453:Prostaglandins; D000509:alpha-Fetoproteins; D011374:Progesterone; D011266:Pregnancy-Associated Plasma Protein-A