Exocrine pancreatic secretion: effect of subarachnoidal application of cholecystokinin octapeptide in rats.
Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion. It was observed that for subarachnoidal administration of CCK-8 both protein and amylase outputs were higher than that seen after i.v. injection. This result is consistent with the presence of central CCK receptors which when activated can enhance pancreatic exocrine secretion. The blockade of the effect of CCK by administration of CCK-8-specific antisera proves the specificity of the subarachnoidal CCK-8 stimulation.
Ormai
S
S
Postgraduate Medical School, Central Research Division, Budapest, Hungary.
Korányi
L
L
Sasvári
M
M
Endröczi
E
E
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012844:Sincalide / Q000494:pharmacology*
D011506:Proteins; D000681:Amylases; D012844:Sincalide