Anti-T and anti-B cell sera in modulation of humoral and cellular reactivity induced by spinal antigen in chickens.
Specific anti-T and anti-B cell sera were used in treatment of allergic encephalomyelitis in chickens. The therapeutic effectivity of anti-T cell serum was very low. Unexpectedly, anti-B as well as normal serum amplified inflammatory reactions in the central nervous system. T and B cell count in peripheral blood was reduced according to the type of antiserum used. Alterations in the anti-myelin IgG, IgM and IgA antibodies level were typical for the course of allergic encephalomyelitis. Mechanisms of activity of anti-T and anti-B cell sera are discussed. We also show that the disease within the central nervous system is accompanied by the symptoms resulting from repeated administration of the xenogeneic sera.
Błaszczyk
B
B
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Giełdanowski
J
J
Viljanen
M
M
Katkiewicz
M
M
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D001402:B-Lymphocytes / Q000276:immunology; D001921:Brain / Q000473:pathology; D002645:Chickens; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology; D007111:Immunity, Cellular; D007958:Leukocyte Count; D004676:Myelin Basic Protein / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000961:Antilymphocyte Serum; D004676:Myelin Basic Protein