[The placebo effect in bone metastatic pain].
In a double-blind multicentre study conducted on patients suffering from bone metastasis pain, an analgesic effect with unexpected qualitative, quantitative and temporal characteristics was observed in the placebo group (n = 38). The placebo was considered effective by doctors and patients in 57 per cent and 51 per cent of the cases respectively. Mean improvement was estimated at 30-40 per cent by self-evaluation, and it persisted for 7 days after the end of the 7-day treatment. Placebo responders were younger than non-responders and showed a tendency to put lower scores on the sensory pain descriptive scales. The possible factors involved and the implications of these findings are discussed in the light of current data on placebo effect.
Boureau
F
F
Unité de Traitement de la douleur, Hôpital Saint-Antoine, Paris.
Leizorovicz
A
A
Caulin
F
F
D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000556:secondary*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D010166:Palliative Care; D010919:Placebos / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors
D010919:Placebos
Effet placebo sur les douleurs métastatiques osseuses.