Association between haptoglobin groups and hereditary predisposition for bronchial asthma.
Haptoglobin (Hp) groups were investigated in 148 patients with bronchial asthma. A significant (p less than 0.005) deviation from the expected Hardy-Weinberg equilibrium, with a decreased frequency of heterozygotes, was observed among patients with a family history of asthma. This deviation was more pronounced among patients with adult onset of asthma. The presence or absence of atopy had no significant influence on the phenotype distribution.
Fröhlander
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Department of Medical Genetics, University of Umeå, Sweden.
Stjernberg
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N
D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism; D000367:Age Factors; D001249:Asthma / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005192:Family Health; D005260:Female; D006242:Haptoglobins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D008297:Male
D000209:Acute-Phase Proteins; D006242:Haptoglobins