Variations of histamine release in an atopic population. II. Clinical situation according to age and duration of immunotherapy.
Mediators released as a consequence of allergen-IgE interaction constitute the elements responsible for the clinical manifestations of allergic diseases. To date, numerous mediators have been described although histamine is the fundamental agent in the majority of these reactions. In the present work, we analyzed the influence of 3 different factors (sex, age and duration of immunotherapy) on "in vitro" antigen-specific histamine release. The study was done on 226 individuals mono-sensitized to Dermatophagoides. Of these patients, 195 were asthmatics and 31 rhinitics; their ages ranged between 1 and 72 years, with an average of 21.87 +/- 15.36. There were no significant differences in histamine release capacity in relation to the patient's sex. As to age, there were marked differences in patients older than 40 years; these patients released less histamine (in percentage as well as in total levels) than those patients with less than 20 years of age, with a probability of less than 0.05. When comparing the different groups studied in relation to the time of immunotherapy, we found a statistically significant decrease in histamine release percentages between those patients with less than 1 year of immunotherapy and those with more than 3 years (p less than 0.05), reaching a reduction of 16.33%.
Gamboa
P M
PM
Departamento de Alergología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Castillo
J G
JG
Wong
E
E
de la Cuesta
C G
CG
Oehling
A
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000485:Allergens / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000209:etiology / Q000276:immunology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D007223:Infant; D008297:Male; D008875:Middle Aged; D008925:Mites; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology / Q000276:immunology / Q000628:therapy
D000485:Allergens; D039741:Antigens, Dermatophagoides