[Effects of intra-arterial infusion chemotherapy in local recurrence of anal cancer].
At present, there is no effective local therapy for skin metastasis after radical operation for anorectal cancer. Most local recurrent lesions of this type are not indications for surgery. However, successful control of the local lesion can enhance the quality of life because the general condition is good. We performed intra-arterial infusion chemotherapy for skin metastasis after Miles operation for anorectal cancer and observed marked effects. A 62-year-old female with anal cancer underwent Miles operation in November, 1987. About July, 1988, an indurated mass appeared in the perineal region but was left untreated. However, urinary disturbance due to the mass developed, and she was admitted in September. A catheter for Intra-arterial infusion chemotherapy was inserted via the lateral deep femoral artery, and 5-FU, BLM, and MMC were administered. Local bleeding was stopped, and the mass began to be reduced about 16 days after the administration. After about 1 month, no secretion from the mass was observed, and the urinary disturbance improved due to a reduction in the mass.
Mieno
K
K
First Surgical Dept. Teikyo University School of Medicine.
Takeda
Y
Y
Satoi
Y
Y
Amino
K
K
Miura
S
S
Shikata
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary
D008937:Mitomycins; D001761:Bleomycin; D016685:Mitomycin; D005472:Fluorouracil