[Myasthenia gravis and pregnancy. Review of the literature and considerations on the immunoprotective effect of alpha-fetoprotein through the observation of a clinical case].
Myasthenia gravis is an autoimmune disorder characterized by a reduction of muscular strength. It is associated with production of anti-acetylcholine-receptor antibodies and with the consequent decrease of muscular acetylcholine receptors. The Authors have studied this pathology during the pregnancy and the puerperium in a myasthenic patient and in her newborn, evaluating seric AChRAbs title and seric alpha-fetoprotein levels, to investigate the possible correlation among these parameters and MG. The study shows that with low seric levels of AChRAbs the mother had a progressive symptomatological impairment of MG from 36th week of pregnancy to term and in puerperium too; the newborn didn't show any sign of pathology. The possible immuno-protective role of alpha-FP in maternal and fetal MG evolution is discussed.
Gliaschera
M
M
Biver
P
P
Brunori
E
E
Romani
L
L
Tarani
A
A
de Luca Brunori
I
I
D000328:Adult; D000906:Antibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology; D000509:alpha-Fetoproteins / Q000502:physiology*
D000906:Antibodies; D011950:Receptors, Cholinergic; D000509:alpha-Fetoproteins
Miastenia gravis e gravidanza. Revisione della letteratura e considerazioni sull'azione immuniprotettiva dell' alpha-fetoproteina attraverso l'osservazione di un caso clinico.