Lectin-binding sites in squamous cell carcinomas and keratoacanthomas.
The lectin-binding pattern of malignant and benign human epidermal tumours was studied. Twelve squamous cell carcinomas and ten kerato-acanthomas were investigated, using fluorochrome-conjugated lectins. Lectins used were Canavalia ensiformis agglutinin (Con-A), Helix pomatia agglutinin (HPA), Phaseolus vulgaris agglutinin (PHA-L), and Ricinus communis agglutinin (RCA-120). Two types of fluorescence pattern, Intercellular 'Pemphigus-like' and Peritumoral, were noted. Both allowed classification of these tumours on the basis of their lectin-binding reactivity. Moreover, the expression of receptors for these lectins made it possible to distinguish between low-grade and well-differentiated squamous cell carcinomas.
Ramírez-Bosca
A
A
Department of Dermatology, Faculty of Medicine, University of Valencia, Spain.
Reano
A
A
Valcuende-Cavero
F
F
Thivolet
J
J
Castells-Rodellas
A
A
D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007636:Keratoacanthoma / Q000378:metabolism* / Q000473:pathology; D037102:Lectins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000473:pathology
D037102:Lectins