The influence of tetracyclines on the aggregation of free and membrane-bound polysomes and on the RNA content of the liver of mice.
Tetracycline (100 micrograms/g) and, to a lesser extent, doxycycline (50 and 100 micrograms/g) inhibited the aggregation of free but not of membrane-bound polysomes in the livers of female NMRI mice. In addition tetracycline decreased the RNA content of the fraction of membrane-bound polysomes probably due to detachment from their membrane sites.
Hopf
G
G
Lehrstuhl für Toxikologie und Pharmakologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Böcker
R
R
Estler
C J
CJ
D000818:Animals; D004247:DNA / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011132:Polyribosomes / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000032:analysis / Q000378:metabolism*; D013754:Tetracyclines / Q000494:pharmacology*
D011506:Proteins; D013754:Tetracyclines; D012313:RNA; D004247:DNA; D004318:Doxycycline