title: Second-look laparotomy in endodermal sinus tumor: a report of two patients with normal levels of alpha-fetoprotein and residual tumor at reexploration.
abstract: The role of second-look laparotomy in the management of patients with endodermal sinus tumor of the ovary is controversial. We report two women who converted to a normal alpha-fetoprotein (AFP) level during treatment with combination chemotherapy, yet were found to have residual endodermal sinus tumor at second-look laparotomy. In view of the limited experience with this rare disease, we continue to recommend second-look laparotomy for patients who have completed chemotherapy for endodermal sinus tumor of the ovary, regardless of the serum AFP level.
authors: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors: J P
authors: JP
authors: Curtin
authors: S C
authors: SC
authors: Rubin
authors: W J
authors: WJ
authors: Hoskins
authors: T B
authors: TB
authors: Hakes
authors: J L
authors: JL
authors: Lewis
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007813:Laparotomy; D008649:Mesonephroma / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D012086:Reoperation; D000509:alpha-Fetoproteins / Q000097:blood*
chemical_list: D000509:alpha-Fetoproteins