Tubular adenomatous metaplasia (nephrogenic adenoma) of the female urethra.
We present a case of tubular adenomatous metaplasia (nephrogenic adenoma) arising within a urethral diverticulum in a woman complaining of a vaginal mass with dyspareunia. This lesion, which uncommonly affects the urethra, may clinically manifest as a gynecologic condition and mimic a low-grade adenocarcinoma on pathologic assessment. Criteria for diagnosis and current concepts of pathogenesis are discussed. Our findings, including an immunocytochemical work-up, support the concept of a reactive metaplastic response rather than nephrogenic differentiation.
Odze
R
R
Department of Pathology, McGill University, Montreal, Quebec, Canada.
Bégin
L R
LR
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008679:Metaplasia; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014523:Urethral Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
D007633:Keratins