Transfer RNA is cleaved by activated bleomycin.
Activated bleomycin is shown for the first time to cleave tRNA in a specific and dose-dependent manner. Adenine and uracil are released in the reaction. Bleomycin and Fe(III)-bleomycin bind to yeast tRNAPhe) in analogy with the known behavior of the drug with B-DNA.
Magliozzo
R S
RS
Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461.
Peisach
J
J
Ciriolo
M R
MR
D001761:Bleomycin; D055598:Chemical Phenomena; D002621:Chemistry; D004578:Electron Spin Resonance Spectroscopy; D005290:Ferric Compounds; D005296:Ferrous Compounds; D066298:In Vitro Techniques; D012331:RNA, Fungal; D012345:RNA, Transfer, Amino Acid-Specific; D012360:RNA, Transfer, Phe
D005290:Ferric Compounds; D005296:Ferrous Compounds; D012331:RNA, Fungal; D012345:RNA, Transfer, Amino Acid-Specific; D012360:RNA, Transfer, Phe; D001761:Bleomycin