Enzyme histochemical and ultrastructural approach in orotic acid-induced fatty liver and their recovery process in Wistar rats.
Fatty liver was induced in Wistar rats by orotic acid and the recovery process was studied by enzyme histochemical staining for non specific esterase, lipase and by ultrastructural investigation. Enzyme histochemically, these enzyme activities were markedly decreased in orotic acid-induced fatty liver. However, during the recovery process after the end of orotic acid administration, these enzyme activities clearly appeared. Under these conditions, no significant ultrastructural alterations could be detected. Based on our data, pathogenesis of orotic acid-induced fatty liver was discussed.
Murakoshi
M
M
Department of Pathology, School of Medicine, Tokai University, Japan.
Suemizu
H
H
Watanabe
K
K
D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000032:analysis*; D003593:Cytoplasm / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000473:pathology; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D006056:Golgi Apparatus / Q000473:pathology; D006651:Histocytochemistry; D008049:Lipase / Q000032:analysis*; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000473:pathology; D009963:Orotic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
D009963:Orotic Acid; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D008049:Lipase