[Immunohistochemical study of schwannoma--with respect to the histogenesis of Antoni B area].
Sixty two cases of schwannoma were studied immunohistochemically and ultrastructurally for further understanding of the histogenesis of Antoni B area. For immunohistochemical study, the author used the antibodies against fibronectin (FN), factor XIIIa (XIIIa), and collagen type I and III. FN and XIIIa were positive with a fibrillar pattern in Antoni B area. Collagen type I and III were positive in the extracellular matrix of Antoni B area, but not in Antoni A area. Ultrastructurally, Antoni B area consisted of degenerative Schwann cells and fibroblasts. These findings closely resemble those of fibrogenesis seen in the wound healing process or in the stroma around tumor. The author concluded that the fibrogenesis occurring in Antoni B area reflects the stromal reaction against Antoni A area, in contrast to the previous studies that Antoni B area only represents degenerative change of Antoni A area.
Watanabe
H
H
Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000648:ultrastructure; D005121:Extremities / Q000294:innervation; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009442:Neurilemmoma / Q000473:pathology* / Q000648:ultrastructure; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology / Q000648:ultrastructure; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000648:ultrastructure; D013194:Staining and Labeling; D000160:Vestibulocochlear Nerve Diseases / Q000473:pathology