HEMA-particles phagocytosis of rat neutrophils.
A micromethod for testing of phagocytosis employing synthetic hydrophilic HEMA particles seems to be suitable for an examination of rat neutrophils. The normal phagocytic activity was 53.7 +/- 1.4%, phagocytic index 8.2 +/- 0.7, and the number of phagocytosing neutrophils was found to be 74 +/- 5.10(6)/l. Using HEMA particles, an experimentally induced depression of rat neutrophil phagocytosis after cyclophosphamide or benflurone was well detected and quantified.
Berger
J
J
Laboratory of Haematology, Research Institute for Pharmacy and Biochemistry, Pardubice, CSSR.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005449:Fluorenes / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D011102:Polyhydroxyethyl Methacrylate; D011109:Polymethacrylic Acids; D051381:Rats; D011919:Rats, Inbred Strains
D005449:Fluorenes; D011109:Polymethacrylic Acids; D011102:Polyhydroxyethyl Methacrylate; C034234:VUFB 13468; D003520:Cyclophosphamide