The effect of beta-blockade on platelet function and fibrinolytic activity.
Two groups of hypertensives and a group of migraine sufferers were tested during treatment with the nonselective beta-blocker propranolol and the beta 1-selective metoprolol. During treatment with propranolol, an increased platelet aggregability and a decrease in platelet content of cyclic AMP were seen when compared with metoprolol treatment. In addition, propranolol treatment increased the plasma level of adrenaline as well as the euglobulin clot lysis time.
Winther
K
K
Department of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008790:Metoprolol / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D011433:Propranolol; D000242:Cyclic AMP; D008790:Metoprolol; D004837:Epinephrine