[Long-term tolerance of specific hyposensitization with the aid of calcium phosphate-adsorbed mite extracts].
90 children receive a specific hyposensitization with calcium phosphate adjuvant purified Dermatophagoides pteronyssinus allergens. We note 44% very good results, 37% good results and 19% failures. We propose to begin with 1/1,000,000 concentration every other day until 1/10,000 concentration is obtained under antihistamine protection. Tolerance is satisfactory: moderate respiratory reaction are pointed out for 22 patients. No anaphylactic shock is encountered. For 80 children with more than three years recall, we totalled 3,700 injections for 340 watching years. Only eight patients are sight lost. 1/10,000 concentration is obtained in 72/80 followed up children.
Lelong
M
M
Service de Pédiatrie, Centre Hospitalier, Lens.
Miersman
R
R
D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage*; D002130:Calcium Phosphates; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D000939:Epitopes / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D007164:Immunosorbents; D012130:Respiratory Hypersensitivity / Q000628:therapy*
D000485:Allergens; D002130:Calcium Phosphates; D000939:Epitopes; D007164:Immunosorbents; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous
Tolérance à long terme de l'hyposensibilisation spécifique à l'aide d'extraits d'acariens adsorbés sur phosphate de calcium. A propos de 90 observations traitées de façon semi-rapide.