The anti-inflammatory effect of organo-heparinoid cream after bilateral mandibular osteotomies.
The aim of the present study was to compare the effect on swelling after bilateral osteotomies of the mandible of treatment with organo-heparinoid (Hirudoid) cream and that of a placebo cream. 12 patients (7 female, 5 male), median age of 29.5 years, were included in the study. 5 patients received bilateral sagittal-split procedures for symmetrical mandibular advancement, and 7 patients received bilateral mandibular osteotomies for symmetrical mandibular set-back. Each of the 2 operated sides were randomized for treatment with active medication or placebo; 1.5 g of the active- or placebo cream were carefully rubbed into the skin above the masseteric muscle 4 times a day for 4 days. Periodic identical CT-scans were performed to evaluate swelling; patients were CT-scanned preoperatively and once or twice postoperatively. 3 variables were used to assess the swelling: (1) thickness of the subcutis; (2) maximum thickness of the masseteric muscle; (3) cross-sectional area of the soft tissues facial to the ramus of the mandible. No significant differences in postoperative swelling could be demonstrated between the 2 treatments. There were no detectable systemic effects of the treatment with organo-heparinoid.
Sindet-Pedersen
S
S
Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Denmark.
Lund
E
E
Simonsen
E K
EK
Stenbjerg
S
S
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control*; D005260:Female; D005782:Gels; D006496:Heparinoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008406:Masseter Muscle; D008410:Masticatory Muscles; D010027:Osteotomy / Q000009:adverse effects* / Q000379:methods; D010919:Placebos; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D006496:Heparinoids; D010919:Placebos; C046596:Hirudoid