[Heterogeneity of epithelial cells in the human thymus during early ontogeny (an immunohistochemical study)].
An immunohistochemical study of thymic epithelial cells at an early stage of prenatal development of man (II-III lunar month of pregnancy) was carried out. Serial cryostatic sections were prepared by a standardized method (Takacs, 1987) with monoclonal antibodies against four types of tonofilament-bound keratinic antigens (BH11, BG3, AG3, T2/30). There were phenotypic-heterogeneity, caused by differences in the expression of keratinic antigens, as well as regional peculiarities in inner thymic distribution of various types of keratin-positive epithelial cells. The obtained results are discussed in connection with the possibility of securing specific epithelial microencirclement of thymic lymphocytes during their proliferation and differentiation at early ontogeny.
Marinova
Ts
Ts
D000941:Antigens / Q000032:analysis; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology* / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D007633:Keratins
Kheterogennost na epitelnite kletki na timusa u chovek v rannata ontogeneza (imunokhistokhimichno izsledvane).