CD5 positive B lymphocytes: a link between autoimmunity and B-cell oncogenesis.
A strong relationship exists between autoimmunity and B-cell oncogenesis. Recent evidence indicates that CD5-positive B-cells are involved in both the production of (germ-line encoded) autoantibodies and the clonal B-cell expansions. Thus, this special B-cell subset represents a strong link between autoimmune state and B-cell malignancies. Immunotherapy of both autoimmune diseases and B-cell malignancies. Immunotherapy of both autoimmune diseases and B-cell cancers should consider the relationship between both processes.
Bataille
R
R
INSERM U 291, Immunopathologie des Affections Tumorales et Autoimmunes, ZOLAD, Montpellier, France.
Klein
B
B
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D006801:Humans; D008223:Lymphoma / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*
D000943:Antigens, Differentiation; D018956:CD5 Antigens