Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane.
Plasma gamma-hexachlorocyclohexane (gamma-HCH) and three urinary trichlorophenols were measured in forestry workers who were engaged in planting seedlings treated with gamma-HCH. These two procedures were assessed as potential biological monitoring methods and the data were compared with reported clinical symptoms. The measurement of plasma gamma-HCH was considered to be a feasible and valid monitoring method for use in routine practice and is a useful indicator of gamma-HCH absorption. The data were used to illustrate the need to be vigilant about personal hygiene and the efficacy of protective clothing. Plasma gamma-HCH concentrations above 70 nmol/l were measured in two workers which coincided with persistent non-specific clinical symptoms. Trichlorophenols were identified in urine but the extensive and variable metabolism of gamma-HCH makes this approach less suitable for biological monitoring.
Drummond
L
L
Occupational Medicine and Hygiene Laboratory, Health and Safety Executive, London, UK.
Gillanders
E M
EM
Wilson
H K
HK
D000383:Agriculture; D002733:Chlorophenols / Q000652:urine; D004781:Environmental Exposure; D001556:Hexachlorocyclohexane / Q000009:adverse effects / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D014197:Trees
D002733:Chlorophenols; C009534:2,4,5-trichlorophenol; D001556:Hexachlorocyclohexane; C056693:2,3,5-trichlorophenol; C024564:2,4,6-trichlorophenol