title: Immunopathological investigations in purpura pigmentosa chronica.
abstract: We studied the cell infiltrates and antigenic characteristics of keratinocytes in biopsies from purpura pigmentosa chronica (PPC), with eleven monoclonal antibodies against several cell surface markers of effector and/or accessory cells of the immune system and compared the reactivity patterns with those in biopsies from uninvolved skin. Immunohistochemical staining revealed a predominance of activated helper T lymphocytes in the cutaneous inflammatory infiltrate. In contrast to uninvolved skin, lesional keratinocytes were found to express HLA-DR, OKM5, Leu-8 and Leu-11b (CD16) antigens in all biopsies from the involved skin. We demonstrate here for the first time the in vivo expression of several effector and/or accessory cell markers on lesional keratinocytes and infiltrate cells in PPC.
authors: Department of Dermatology, University of Erlangen-Nürnberg, FRG.
authors: M
authors: M
authors: Simon
authors: A
authors: A
authors: Heese
authors: A
authors: A
authors: Götz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D002908:Chronic Disease; D004817:Epidermis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007633:Keratins; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000150:complications / Q000276:immunology* / Q000473:pathology; D011693:Purpura / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006680:HLA Antigens; D007633:Keratins