title: Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variation.
abstract: The nucleotide sequence of the structural gene for staphylococcal enterotoxin type C3 (entC3) was determined. This gene contains 798-base-pair open reading frame that encodes a protein of 266 amino acid residues. Sequence analysis suggests that staphylococcal enterotoxin type C3 is synthesized in a precursor form that is processed to yield a mature extracellular form of 238 amino acid residues (molecular weight, 27,438). The entC3 gene is closely related to the gene for staphylococcal enterotoxin type C1, with 98% nucleotide sequence identity. Sequence comparisons between the entC3, entC1, and entB genes suggest that an ancestral entC1-like gene was formed by recombination between the entC3 and entB genes.
authors: Department of Bacteriology, University of Wisconsin-Madison 53706.
authors: J L
authors: JL
authors: Couch
authors: M J
authors: MJ
authors: Betley
mesh_terms: D000595:Amino Acid Sequence; D000940:Antigenic Variation; D001483:Base Sequence; D004768:Enterotoxins / Q000235:genetics* / Q000276:immunology; D000939:Epitopes / Q000235:genetics; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D013211:Staphylococcus aureus / Q000235:genetics*
chemical_list: D004768:Enterotoxins; D000939:Epitopes; C034959:enterotoxin C, staphylococcal