Metabolic changes in women using a long-acting monthly oral contraceptive and return of ovulation on discontinuation.
Metabolic changes were investigated in two groups of women using oral contraceptives for 5 to 16 years. Blood samples were taken during the last cycle of oral contraceptive use and three months post-treatment. One group had used a monthly oral contraceptive (MOC, 3mg quinestrol and 10mg 16-methylene chlormadinone acetate) and the second group a daily oral contraceptive (DOC, 35 micrograms ethynylestradiol and 0.625 mg norethisterone). During treatment there were increases in serum total cholesterol and triglycerides but not HDL-C, in plasma total cortisol but not in renin activity, angiotensin II or urinary free cortisol excretion, in hemoglobin and some coagulation factors but not Factor X or antithrombin III, platelet function or fibrinolysis. The area under the blood glucose concentration-time curve, but not that for serum insulin, was slightly increased and there was no change in fasting blood sugar concentrations. All metabolic parameters, except plasma cortisol, which had shown an increase on treatment, had decreased to control levels within 3 months. Ovulation returned promptly in all women, the mean time being 70 days for Group MOC and 44 days for Group DOC. Thus, in spite of the long duration of use of the oral contraceptives, metabolic changes were minor.
Yu
A F
AF
First Affiliated Hospital, Tianjin Medical College, People's Republic of China.
Wu
S X
SX
Liu
J L
JL
Liu
A R
AR
Li
J Z
JZ
Wu
J H
JH
Hu
Z Z
ZZ
Yin
B Y
BY
Xu
G X
GX
Fotherby
K
K
D000328:Adult; D002715:Chlormadinone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D008076:Cholesterol, HDL / Q000097:blood; D003276:Contraceptives, Oral / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D009640:Norethindrone / Q000494:pharmacology / Q000627:therapeutic use; D010060:Ovulation / Q000187:drug effects*; D011800:Quinestrol / Q000494:pharmacology / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D003276:Contraceptives, Oral; D004338:Drug Combinations; D006454:Hemoglobins; D014280:Triglycerides; D002715:Chlormadinone Acetate; D004997:Ethinyl Estradiol; C010082:chlorsuperlutin; D011800:Quinestrol; D009640:Norethindrone; D006854:Hydrocortisone