title: Light and electron microscopy of keratinization in the laminar epidermis of the equine hoof with reference to laminitis.
abstract: The laminar epidermis (epidermis parietis) of hooves from 14 clinically normal horses, 6 months to 15 years old, was examined by light and electron microscopy and immunofluorescence to measure the contributions of this region to the formation of the hoof wall. By their progressive keratinization to form primary epidermal laminae, the secondary epidermal laminae ultimately contributed about 20% of the thickness of the hoof wall (as revealed in the white line [zona alba]). The keratinized, primary epidermal laminae were developed to a height of 4 mm during their proximodistal-course, much of this obscured because of their basal portion being embedded in the cap horn epidermis. From evaluation of structural changes accompanying keratinogenesis in the cell and determination of the contribution of the laminar epidermis to the formation of laminar horn, cap horn, connecting horn, terminal horn, and the white line, we concluded that the sterile bed concept of a nongerminative role for the secondary epidermal laminae is no longer tenable.
authors: Institut für Veterinär-Anatomie, Histologie und- Embryologie, Freie Universität Berlin, Federal Republic of Germany.
authors: K D
authors: KD
authors: Budras
authors: R L
authors: RL
authors: Hullinger
authors: W O
authors: WO
authors: Sack
mesh_terms: D000818:Animals; D000078404:Epidermal Cells; D004817:Epidermis / Q000648:ultrastructure*; D004848:Epithelium; D005534:Foot Diseases / Q000473:pathology / Q000662:veterinary; D006724:Hoof and Claw / Q000648:ultrastructure*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses / Q000033:anatomy & histology*; D007633:Keratins / Q000502:physiology; D008854:Microscopy, Electron; D013997:Time Factors
chemical_list: D007633:Keratins