Physiological benefits of a pacemaker with dual chamber pacing at low heart rates and single chamber rate responsive pacing during exercise.
Dual chamber rate responsive pacing may be an ideal mode but may result in high current drain and premature battery depletion. To minimize battery drain during exercise, this study compared a combination pacing mode of DDD and ventricular rate responsive pacing (VVIR). Nine patients were studied who had complete heart block, sinus rhythm, DDD pacemakers, and a reduced mean left ventricular ejection fraction of 44%. Patients were exercised in DDD, VVIR, and a combination of DDD at low heart rates and VVIR at mean heart rates over 89 bpm. Blood pressure, heart rate, exercise duration, work rate, oxygen uptake, anaerobic threshold, and oxygen pulse were measured. There was no difference in symptoms or in mean cardiopulmonary function indices including exercise duration 10.7, 10.3, 10.3 minutes; heart rate 127, 133, 136 bpm; oxygen uptake 1.4, 1.5, 1.5 L/minute; or anaerobic threshold 5.6, 5.5, 5.7 minutes (p greater than 0.05) in any mode. A pacemaker that provides atrioventricular synchrony at low heart rates with ventricular rate responsiveness at high heart rates may be an alternative mode for some patients.
French
W J
WJ
Department of Medicine, UCLA School of Medicine.
Haskell
R J
RJ
Wesley
G W
GW
Florio
J
J
D000328:Adult; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005080:Exercise Test; D006327:Heart Block / Q000628:therapy*; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D010138:Pacemaker, Artificial; D005082:Physical Exertion; D011659:Pulmonary Gas Exchange