Alterations in sodium-potassium regulation in mononuclear leucocytes from young borderline hypertensive and offspring of hypertensive patients.
Membrane ion transports were investigated in lymphocytes from young normotensive and borderline hypertensive offspring with and without heredity for hypertension. Borderline hypertension per se was associated with an enhancement of sodium-potassium pump activity. Heredity per se was associated with increased sodium influx and ouabain-resistant sodium efflux.
Nielsen
J R
JR
Department of Medicine b, Odense University Hospital, Denmark.
Pedersen
K E
KE
Klitgaard
N A
NA
Johansen
T
T
D000293:Adolescent; D000328:Adult; D000802:Angiotensin Amide / Q000378:metabolism*; D000804:Angiotensin II / Q000031:analogs & derivatives*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D014655:Vascular Resistance
D007473:Ion Channels; D000804:Angiotensin II; D000802:Angiotensin Amide; D012964:Sodium; D011188:Potassium