Effect of antihistamines on interferon production by leukocytes from sensitized and non-sensitized mice.
The effect of four antihistamines (Intal, Zaditen, Tavegyl, Benzhydramine) on interferon production in mice was investigated. The agents were administered in vivo to ovalbumin-sensitized and non-sensitized mice, or in vitro to isolated peritoneal cell cultures. The cells were induced for interferon production with Newcastle virus. It was shown that Tavegyl and Benzhydramine, both after in vivo and in vitro administration, inhibit interferon production, while Intal and Zaditen had no effect.
Szalaty
H
H
Department of Immunology of Infectious Diseases, Polish Academy of Sciences, Wrocław.
Jankowska
R
R
Małolepszy
J
J
D000818:Animals; D002974:Clemastine / Q000494:pharmacology*; D004155:Diphenhydramine / Q000494:pharmacology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007114:Immunization; D066298:In Vitro Techniques; D007372:Interferons / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011759:Pyrrolidines / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D011759:Pyrrolidines; D004155:Diphenhydramine; D007372:Interferons; D002974:Clemastine