Modification of radioiodine incorporation into the fetuses and newborn rats by thyroid blocking agents.
Combination of thyroid blocking agents do not seem to be embryo- and fetotoxic when applied in reduced doses. These agents decrease significantly the radioiodine uptake by fetuses and sucklings. By extrapolation of these results to humans, based on the mass-unit efficient doses [13, 16, 23, 24], their combination can be recommended for the prophylaxis of radioiodine intoxication of fetuses and infants.
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Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Hungary.
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D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D000833:Animals, Suckling / Q000378:metabolism; D013956:Antithyroid Agents / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D010472:Perchlorates / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D011193:Potassium Iodide / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000378:metabolism
D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D010472:Perchlorates; D017680:Potassium Compounds; D011193:Potassium Iodide; C009006:potassium perchlorate; D011188:Potassium