title: Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation.
abstract: Granulocyte colony-stimulating factor (G-CSF) was administered by continuous subcutaneous infusion to 15 patients with non-myeloid malignancies treated by high-dose chemotherapy and autologous bone marrow infusion. G-CSF was given at variable dosage based on neutrophil count. Sustained serum levels of G-CSF were achieved. Neutrophil recovery was accelerated in G-CSF treated patients compared with 18 historical controls and exceeded 0.5 x 10(9)/l at a mean of 11 days after marrow infusion compared with 20 days for controls, a significant difference. This reduction led to significantly fewer days of parenteral antibiotic therapy, 11 versus 18 days in controls, and less isolation in reverse-barrier nursing, 10 versus 18 days.
authors: Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Victoria.
authors: W P
authors: WP
authors: Sheridan
authors: G
authors: G
authors: Morstyn
authors: M
authors: M
authors: Wolf
authors: A
authors: A
authors: Dodds
authors: J
authors: J
authors: Lusk
authors: D
authors: D
authors: Maher
authors: J E
authors: JE
authors: Layton
authors: M D
authors: MD
authors: Green
authors: L
authors: L
authors: Souza
authors: R M
authors: RM
authors: Fox
mesh_terms: D000380:Agranulocytosis; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation / Q000379:methods*; D002066:Busulfan / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003115:Colony-Stimulating Factors / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D016179:Granulocyte Colony-Stimulating Factor; D006689:Hodgkin Disease / Q000097:blood / Q000628:therapy*; D006801:Humans; D007260:Infusion Pumps; D007263:Infusions, Parenteral; D007958:Leukocyte Count / Q000187:drug effects; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000628:therapy*; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide; D002066:Busulfan