Serum levels of interleukin-2 receptor and disease activity in patients with IgA nephropathy.
The levels of serum interleukin-2 receptor (IL-2R) were studied by enzyme-linked immunosorbent assay (ELISA) in patients with IgA nephropathy. The aim of the present study was to determine if levels of serum IL-2R might correlate with disease activity in patients with IgA nephropathy. Twenty-eight patients with IgA nephropathy were examined. This study showed a significant correlation between the levels of serum IL-2R and disease activities, i.e., levels of urinary protein, blood urea nitrogen (BUN) and uric acid, in patients with IgA nephropathy. The levels of serum IL-2R in patients with moderate or advanced stage of IgA nephropathy were significantly higher than those in patients with the minimal or slight stage of this disease or in healthy adults. It was suggested that the measurement of serum IL-2R is useful in evaluating the degree of disease activity and/or prognosis in patients with IgA nephropathy.
Tomino
Y
Y
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Ozaki
T
T
Koide
H
H
Takahashi
M
M
Ito
K
K
D000328:Adult; D001806:Blood Urea Nitrogen; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000150:complications; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013194:Staining and Labeling; D014527:Uric Acid / Q000097:blood
D015375:Receptors, Interleukin-2; D014527:Uric Acid