Chronic exposure of primates to 60-Hz electric and magnetic fields: II. Neurochemical effects.
We exposed Macaca nemestrina (pig-tailed macaques) to electric (E) and magnetic (B) fields ranging in intensity from 3 kV/m and 0.1 G to 30 kV/m and 0.9 G for three 21-day (d) periods. Experimental animals were exposed to sham E and B fields for two 21-d periods, one prior to and one following actual exposure to E and B fields, resulting in a total of five 21-d periods. Control animals were exposed to sham E and B fields for the entire 105-d interval. At the end of each 21-d period cerebrospinal fluid (CSF) was obtained by lumbar puncture and analyzed for concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), metabolites of dopamine and serotonin neurotransmitters, respectively, by high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Results are based on an examination of six experimental and four control animals. Exposure to E and B fields at all strengths was associated with a significant decline in CSF concentrations of both HVA and 5-HIAA when statistical comparisons were made against values obtained at the end of the preexposure interval. However, HVA returned to preexposure levels during the postexposure period, while 5-HIAA did not. No significant change in the concentrations of HVA or 5-HIAA was noted in the control animals. These results strongly suggest that exposure of the nonhuman primate to E and B fields can significantly affect specific biochemical estimates of nervous system function. These effects may involve alterations either in neuronal activity or in the activity of enzymes that catabolize the neurotransmitters.
Seegal
R F
RF
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
Wolpaw
J R
JR
Dowman
R
R
D000818:Animals; D004574:Electromagnetic Fields / Q000009:adverse effects*; D055590:Electromagnetic Phenomena / Q000009:adverse effects*; D004781:Environmental Exposure; D006719:Homovanillic Acid / Q000528:radiation effects; D006897:Hydroxyindoleacetic Acid / Q000528:radiation effects; D008254:Macaca nemestrina; D008297:Male; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid / Q000528:radiation effects*
D018377:Neurotransmitter Agents; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid