title: Pituitary adenomas in Cushing's disease: do they arise from the intermediate lobe?
abstract: Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
authors: Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
authors: C
authors: C
authors: Raffel
authors: J E
authors: JE
authors: Boggan
authors: L F
authors: LF
authors: Eng
authors: R L
authors: RL
authors: Davis
authors: C B
authors: CB
authors: Wilson
mesh_terms: D000236:Adenoma / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000911:Antibodies, Monoclonal; D001369:Axons / Q000648:ultrastructure; D003480:Cushing Syndrome / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007382:Intermediate Filaments / Q000276:immunology; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling / Q000379:methods
chemical_list: D000911:Antibodies, Monoclonal; D000324:Adrenocorticotropic Hormone