The prevalence of AIDS, AIDS related complex and HIV seropositivity in a large population of patients with congenital clotting disorders.
We have investigated up to the beginning of 1987 114 patients with congenital clotting disorders. 84 had received plasma and/or clotting factors concentrates. 18 out of 84 (21%) had leukopenia, thrombocytopenia, or both. 64 out of 84 (76%) had been infected by hepatitis B virus. The great majority of them (62 out 64) developed adequate immunity (anti Hbs antibodies). Despite this, 47 out 84 (57%) showed persistently elevated transaminases. 17 out of 84 (20%) had HIV-seropositivity. Among them, 7 are free of symptoms related to such a virus up to present time, 8 developed AIDS-related complex and 2 had the full-blown AIDS and died. Non significant difference in HIV seroconversion or its clinical manifestations was noted depending on the administration of factor VIII concentrates versus prothrombin complex concentrates. In contrast, plasma administration appeared to be associated with a lower risk of viral transmission. No abnormality was observed in patients who had never received haemoderivatives, except the presence of anti Hbs antibodies in 1 of them.
Girolami
A
A
Institute of Medical Semeiotics, University of Padua Medical School, Italy.
Luzzatto
G
G
Dal Bo Zanon
R
R
Lazzaro
A R
AR
De Rossi
A
A
Stocco
D
D
D000386:AIDS-Related Complex / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000151:congenital* / Q000628:therapy; D005260:Female; D006679:HIV Seropositivity / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged