[Changes in the prekeratin set and in the intracellular distribution of intermediate filaments during the embryonic development of the liver in the rat].
Monoclonals against three individual proteins of the epithelial intermediate filaments, prekeratins (PK40, PK49, PK55), were used for immunofluorescence studies of the cryostat sections of the rat embryonic liver. The dynamics of expression and intracellular distribution of prekeratins reflects that of morphological rearrangement of the liver. The development of the system of liver beams was accompanied by changes in the expression and intracellular distribution of PK49 and PK55 and the development of the system of bile ducts by changes in all three PKs. From day 20-21 of embryogenesis all three PKs are expressed in cholangiocytes, while PK49 and PK55 in hepatocytes only.
Chipysheva
T A
TA
Gel'shteĭn
V I
VI
Troianovskiĭ
S M
SM
Bannikov
G A
GA
D000818:Animals; D000911:Antibodies, Monoclonal; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D005455:Fluorescent Antibody Technique; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D007382:Intermediate Filaments / Q000648:ultrastructure*; D007633:Keratins / Q000378:metabolism*; D008099:Liver / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D000911:Antibodies, Monoclonal; D007381:Intermediate Filament Proteins; D011498:Protein Precursors; C004818:prekeratin; D007633:Keratins
Izmenenie nabora prekeratinov i vnutrikletochnogo raspredeleniia promezhutochnykh filamentov v protsesse émbrional'nogo razvitiia pecheni krys.