[5-HIAA: perspectives in nephrology].
5-Hydroxyindoleacetic acid (5-HIAA) is the chief end-product of serotonin metabolism. The gastrointestinal tract is the main source of urinary 5-HIAA. The rest originates from the degradation of brain or platelet serotonin stores. Main abnormalities in 5-HIAA excretion have been observed in carcinoid tumors (elevation) or hyperphenylalaninemia (diminution) as well as in migraine. Estimation of renal blood flow is a new application of 5-HIAA measurements. This stems from the elimination process of this weak organic acid which combines glomerular filtration and proximal tubular secretion. Thus 5-HIAA is extracted by the kidney in high amounts as indicated by a high renal extraction ratio. The renal clearance of 5-HIAA seems a good estimation of renal blood flow. Therefore fluctuations of this endogenous compound could be used to quantify the effects of physiological manipulations or drugs on renal blood flow.
Elghozi
J L
JL
Laboratoire de Pharmacologie, INSERM U7, Faculté de Médecine Necker-Enfants Malades, Paris.
Laude
D
D
D000818:Animals; D002276:Carcinoid Tumor / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000378:metabolism / Q000652:urine*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008881:Migraine Disorders / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D010649:Phenylalanine / Q000097:blood; D051381:Rats; D012079:Renal Circulation; D012701:Serotonin / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D012701:Serotonin; D010649:Phenylalanine; D006897:Hydroxyindoleacetic Acid; D010130:p-Aminohippuric Acid
Le 5-HIAA: perspectives en néphrologie.