The nucleolar organizer regions associated protein (Ag-NORs) in salivary gland tumors.
A silver colloid technique used to identify nucleolar organizer regions associated protein (Ag-NORs) has been applied to 20 salivary gland tumors. The method was readily applicable to the preparations of paraffin-embedded sections and the Ag-NORs were enumerated with ease. A significant difference was found between the numbers of Ag-NORs in the nuclei of malignant salivary gland tumors, such as adenoid cystic carcinoma, mucoepidermoid tumor and adenocarcinoma (with a mean of from 2.05 to 2.78 per nucleus) and those of benign salivary gland, such as pleomorphic adenoma, adenolymphoma (Wartin tumor) and clear cell adenoma (with a mean of from 1.47 to 1.72 per nucleus). It is proposed that the Ag-NORs technique, which is rapid, simple, and inexpensive, may be useful in the differential diagnosis of malignant and benign salivary gland tumors.
Matsumura
K
K
Department of Oral & Maxillofacial Surgery, Yamaguchi University School of Medicine, Ube, Japan.
Sasaki
K
K
Tsuji
T
T
Shinozaki
F
F
D000941:Antigens / Q000032:analysis*; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000032:analysis* / Q000473:pathology; D012834:Silver; D013194:Staining and Labeling
D000941:Antigens; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C051963:nucleolar organizer region associated proteins; D012834:Silver