Influence of dietary hexachlorocyclohexane isomers on lipid metabolism in albino rats.
Dietary intake of beta- and gamma-hexachlorocyclohexane (beta- and gamma-HCH) by albino rats for two weeks (at 800 ppm level) resulted in impairment of lipid metabolism, viz. hyperlipemia and fatty metamorphosis of liver. Liver fat content was increased by both beta- and gamma-HCH. Significant increases were observed in triglyceride and phospholipid fractions of blood in these experimental animals. The incorporation of [14C]acetate and palmitate into liver and blood lipids was higher in HCH pretreated animals, suggesting a higher rate of fat synthesis in liver and of secretion as well.
Srinivasan
K
K
Radhakrishnamurty
R
R
D000284:Administration, Oral; D000818:Animals; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007536:Isomerism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001556:Hexachlorocyclohexane