Potent inhibition of leukotriene (LT) B4 release from human polymorphonuclear leukocytes (PMN) by the PGE1-analogue OP-1206.
The present study investigates the inhibitory action of the PGE1-analogue OP-1206 on stimulated LTB4 release from human PMN. In comparison with PGE2, PGE1 and iloprost, OP-1206 was equipotent to PGE2 and PGE1 as inhibitor of PAF (3 microM) and FMLP (10 microM) induced LTB4 release even in the presence of exogenous arachidonic acid (10 microM). Iloprost was ineffective in this assay at a concentration of 10 microM. The data together with earlier observations suggest that E-type prostaglandins are potent inhibitors of receptor-mediated PMN activation and that these compounds may be valuable for prevention of PMN-associated tissue damage.
Ney
P
P
Institut für Pharmakologie, Universität Düsseldorf, F.R.G.
Hecker
G
G
Schröder
H
H
Schrör
K
K
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D006801:Humans; D016285:Iloprost; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000097:blood* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010972:Platelet Activating Factor / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
D010972:Platelet Activating Factor; D011459:Prostaglandins E, Synthetic; D007975:Leukotriene B4; C025090:ONO 1206; D011464:Epoprostenol; D000527:Alprostadil; D016285:Iloprost; D015232:Dinoprostone