[Human fibrin glue as a new therapeutic concept in cyclophosphamide-induced cystitis and macrohematuria].
Successful treatment of hemorrhagic cystitis after systemic chemotherapy with cyclophosphamide yields up great problems up to now, because all therapeutic modalities that have been done were accompanied with severe side-effects. A 16 year old girl presented massive chemical cystitis and severe bleedings of the bladder mucosa after systemic long-term low-dose chemotherapy with cyclophosphamide. In this case bladder lesions could be cured completely by endoscopic application of fibrin adhesive through a cystoscope. Side-effects were not noted.
Müller-Mattheis
V
V
Urologische Klinik und Poliklinik, Universität Düsseldorf.
Jürgens
H
H
Göbel
U
U
Ackermann
R
R
D000284:Administration, Oral; D000293:Adolescent; D007611:Aprotinin / Q000008:administration & dosage*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced* / Q000628:therapy; D003558:Cystoscopy; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D006417:Hematuria / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D013917:Thrombin / Q000008:administration & dosage*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D003520:Cyclophosphamide; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin
Humaner Fibrinkleber als neues Therapiekonzept bei Cyclophosphamid-induzierter Zystitis und Makrohämaturie.