title: Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes.
abstract: The chromosomal location of representative members of the type I and type II subfamilies of the cytokeratin multigene family was determined using specific cDNA probes in Southern blot hybridization with DNA from somatic cell hybrids. Our results show that the gene encoding human type II cytokeratin 4 resides on chromosome 12 and that encoding type I cytokeratin 15 is located on chromosome 17. The results indicate that cytokeratins are not concentrated in only one cluster. The possibility of the existence of separate type I and type II cytokeratin gene clusters is discussed.
authors: Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
authors: V
authors: V
authors: Romano
authors: P
authors: P
authors: Bosco
authors: M
authors: M
authors: Rocchi
authors: G
authors: G
authors: Costa
authors: R E
authors: RE
authors: Leube
authors: W W
authors: WW
authors: Franke
authors: G
authors: G
authors: Romeo
mesh_terms: D015139:Blotting, Southern; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D015342:DNA Probes; D006801:Humans; D007633:Keratins / Q000235:genetics*; D011544:Pseudogenes
chemical_list: D015342:DNA Probes; D007633:Keratins