Antibody to schistosomulum surface carbohydrate epitopes in subjects infected with Schistosoma haematobium.
The binding of immunoglobulin to carbohydrate epitopes on the surface of Schistosoma mansoni schistosomula was measured with 125I-labelled protein A in sera from 67 Gambian subjects living in a focus of intense S. haematobium transmission. The levels of such antibody differed considerably between subjects and there was significant variation between age groups. The highest mean level, in subjects aged between 8 and 14 years, was significantly greater than that in older subjects. Previous studies have shown that resistance to post-treatment reinfection with S. haematobium is related to age in this focus, and is greatest in those aged 15 or more years. These differing relationships with age suggest that antibodies directed against carbohydrate epitopes on the surface of the schistosomulum do not have a major protective role in man.
Ali
P O
PO
Division of Parasitology, National Institute for Medical Research, Mill Hill, London.
Hagan
P
P
Wilkins
H A
HA
Simpson
A J
AJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis* / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D002241:Carbohydrates / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D005714:Gambia; D006801:Humans; D008875:Middle Aged; D012548:Schistosoma haematobium / Q000276:immunology*; D012550:Schistosoma mansoni / Q000276:immunology; D012553:Schistosomiasis haematobia / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D002241:Carbohydrates; D000939:Epitopes