Genetic heterogeneity of thalassemias in Mexican mestizo patients with hemolytic anemia.
Twenty-eight Hb abnormalities (16 thalassemias, 10 Hb variants and 2 hereditary persistences of fetal hemoglobin) were detected in an etiopathogenic search in 131 patients with hemolytic anemia. The observed thalassemic genotypes [6 beta(0)/beta, 2 (delta beta) (0)/beta(0), 2 beta(0)/beta(+), 2 beta(0)/beta(s), 2 beta(+)/beta(+), 1 beta(+)/beta(s) and 1 (delta beta)(0)/beta] showed heterogeneity in the population studied. A native origin of some of these mutations is considered.
Ibarra
B
B
División de Genética, Instituto Mexicano del Seguro Social, Guadalajara.
Vaca
G
G
de la Mora
E
E
Romero
F
F
Aguilar-Luna
C
C
Mejía
A
A
Esparza
M A
MA
Pérez
G
G
Ornelas
M L
ML
Cantú
J M
JM
D000743:Anemia, Hemolytic / Q000209:etiology*; D005006:Ethnicity; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D007198:Indians, North American; D008297:Male; D008800:Mexico; D010375:Pedigree; D013030:Spain / Q000208:ethnology; D013789:Thalassemia / Q000150:complications / Q000208:ethnology / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D005914:Globins; D005319:Fetal Hemoglobin