[Conformational analysis of anti-arrhythmia agents of the lidocaine series and a model for the mechanism of their action].
After conformation analysis of a number of lidocaine-like antiarrhythmic molecules a simple model of their mode of action is suggested. It is proposed that the hydrophobic antiarrhythmic molecules after their absorption on cytoplasmic membranes concentrate due to polar interactions close to ionic channel proteins, then bind to these proteins and allosterically influence the process of ionic conductance.
Vol'kenshteĭn
M V
MV
Golovanov
I B
IB
Grenader
A K
AK
Ermakov
G L
GL
D000494:Allosteric Regulation; D000889:Anti-Arrhythmia Agents / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects; D008012:Lidocaine / Q000378:metabolism / Q000494:pharmacology*; D008565:Membrane Proteins / Q000378:metabolism; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D008565:Membrane Proteins; D008012:Lidocaine
Konformatsionnyĭ analiz antiaritmikov lidokainovogo riada i model' mekhanizma ikh deĭstviia.