title: Bleeding as a consequence of chorion villus sampling.
abstract: A series of 4 separate studies were conducted to assess the incidence and short term consequence of bleeding associated with chorion villus sampling. Results support previous reports that risk of foetal-maternal transfusion as suggested by a rise in maternal serum alpha-fetoprotein (MSAFP) can occur. This occurrence is not consistent and need not be obvious even after therapeutic abortion. It is also transient and did not complicate mid-trimester neural tube screening or subsequent course of pregnancy. Eighty-seven percent of blood contaminating villus samples are of maternal origin. Following diagnosis 37% of patients reported some vaginal bleeding. This is mainly in the form of spotting which did not preclude normal pregnancy. Foetal loss occurred in 4 of the patients when bleeding considered heavier than spotting continued. In rhesus negative patients prophylactic anti-D gamma-globulin is advised, since neither Kleihauer counts nor MSAFP estimation reliably detect all foetal-maternal transfusions.
authors: D T
authors: DT
authors: Liu
authors: B
authors: B
authors: Jeavons
authors: C
authors: C
authors: Preston
authors: E
authors: E
authors: Slater
authors: E M
authors: EM
authors: Symonds
mesh_terms: D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005331:Fetomaternal Transfusion / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D014592:Uterine Hemorrhage / Q000209:etiology*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins