Iloprost-induced writhing in mice and its suppression by morphine.
Intraperitoneally (i.p.) administered iloprost produced a writhing response indicating nociception. This effect induced by 4 micrograms/kg iloprost was dose dependently protected by morphine with an ED50 (95% confidence limits) value of 0.039 (0.0018-0.067) mg/kg. On the other hand, indomethacin had no effect on iloprost-induced writhing. Thus, this effect of iloprost seems to be relatively more sensitive than other irritants-induced responses on determining the analgesic potency of narcotic drugs.
Akarsu
E S
ES
University of Ankara, Faculty of Medicine, Department of Pharmacology, Turkey.
Palaoglu
O
O
Ayhan
I H
IH
D000818:Animals; D002317:Cardiovascular Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016285:Iloprost; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced*; D013997:Time Factors
D002317:Cardiovascular Agents; D009020:Morphine; D011464:Epoprostenol; D016285:Iloprost