title: Neurokinin A-(4-10): a potent bronchospastic agent virtually devoid of sialologic properties in anaesthetized guinea-pigs.
abstract: The ability of substance P, neurokinin A and its C-terminal fragment, neurokinin A-(4-10), to elicit NK-1 (salivation) and NK-2 (bronchospasm) receptor-mediated responses was investigated in anaesthetized guinea-pigs. Neurokinin A-(4-10) produced a dose-related increase in tracheal insufflation pressure and its maximal effect was similar to that elicited by neurokinin A and significantly greater than that of substance P. On the other hand substance P induced a potent dose-dependent increase of salivation while neurokinin A was significantly less potent. Neurokinin A-(4-10) did not exert any sialologic effect even at the dose of 100 nM/kg. These findings indicate that neurokinin A-(4-10) might be a valuable pharmacological tool for characterizing the involvement of NK-1 and NK-2 receptors in physiological responses in vivo.
authors: Istituto Farmacobiologico Malesci S.p.A., Pharmacology Department, Florence, Italy.
authors: S
authors: S
authors: Manzini
authors: S
authors: S
authors: Conti
authors: C A
authors: CA
authors: Maggi
authors: P
authors: P
authors: Rovero
authors: L
authors: L
authors: Ballati
mesh_terms: D000758:Anesthesia; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced*; D006168:Guinea Pigs; D008297:Male; D015288:Neurokinin A; D009479:Neuropeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D012472:Salivation / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
chemical_list: D009479:Neuropeptides; D010446:Peptide Fragments; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D013373:Substance P; D015288:Neurokinin A; C056408:neurokinin A(4-10)