Acute antihypertensive effect of angiotensin converting enzyme inhibition and calcium entry blockade.
The acute blood pressure response to an angiotensin converting enzyme inhibitor (enalaprilat) was compared in patients with uncomplicated essential hypertension with that obtained under similar conditions with a calcium entry blocker (nifedipine). The patients were studied after a 3 week washout period. At a 48 h interval, each patient received in randomized order either enalaprilat (5 mg i.v.) or nifedipine (10 mg p.o.). Enalaprilat and nifedipine were equally effective in acutely lowering blood pressure. However, good responders to one agent were not necessarily good responders to the other.
Brunner
H R
HR
Division of Nephrology and Hypertension, Centre Hospitalier Universitaire, Lausanne, Switzerland.
Nussberger
J
J
Bidiville
J
J
Waeber
G
G
Porchet
M
M
Waeber
B
B
D000328:Adult; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure; D004656:Enalapril / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D007703:Peptidyl-Dipeptidase A / Q000097:blood
D000804:Angiotensin II; D004656:Enalapril; D007703:Peptidyl-Dipeptidase A; D009543:Nifedipine