title: Subset of natural killer cells is induced by immune complexes to display Fc receptors for IgE and IgA and demonstrates isotype regulatory function.
abstract: Expression of Fc receptors for IgE (FcER) or IgA (FcAR) on purified natural killer (NK) cells was investigated. No FcER+ and a few FcAR+ NK cells were detectable on freshly separated NK (NKH-1+) cells from normal donors. Incubation of NK cells with IgE-anti-IgE immune complexes or IgA-anti-IgA immune complexes induced up to 10 and 20% FcER+ or FcAR+ cells, respectively. These FcR were induced on CD3- but not on CD3+ NKH-1+ cells. In contrast, NK cells from patients with various dysgammaglobulinemias could not be induced to express FcER or FcAR corresponding to their abnormal circulating IgE and/or IgA levels. Enriched FcER+ or FcAR+ induced NK cell supernatants from normals enhanced IgE or IgA synthesis from Ig secreting B cell lines in an isotype-specific fashion without increasing proliferation. Thus NK cells, after interaction with specific Ig isotypes in complexes, express FcR and produce differentiation factors for that isotype.
authors: Department of Medicine, University of California, School of Medicine, Los Angeles 90024.
authors: H
authors: H
authors: Kimata
authors: A
authors: A
authors: Saxon
mesh_terms: D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000502:physiology*; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000378:metabolism; D001796:Blood Protein Disorders / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000378:metabolism; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000378:metabolism; D007132:Immunoglobulin Isotypes / Q000502:physiology*; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D011961:Receptors, Fc / Q000096:biosynthesis*; D017455:Receptors, IgE
chemical_list: D000936:Antigen-Antibody Complex; D015703:Antigens, CD; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E; D012313:RNA