Effects of prednisone, aspirin, and acetaminophen on an in vivo biologic response to interferon in humans.
In healthy volunteers receiving a single intramuscular dose of 18 X 10(6) U interferon alone or after 24 hours of an 8-day course of prednisone (40 mg/day), aspirin (650 mg every 4 hours), or acetaminophen (650 mg every 4 hours), the magnitude of the biologic response to interferon was quantified by measuring the time course of the induction of 2'-5'-oligoadenylate synthetase and resistance to vesicular stomatitis virus infection in human peripheral blood mononuclear cells. Prednisone decreased the AUC of 2'-5'-oligoadenylate synthetase activity (p less than 0.05), whereas administration of aspirin or acetaminophen did not affect this biologic response. No measurable effect was seen during administration of prednisone, aspirin, or acetaminophen on the duration or intensity of vesicular stomatitis virus yield reduction. The side effects seen with interferon administration at the dose tested were not altered in a clinically meaningful manner by prednisone, aspirin, or acetaminophen.
Witter
F R
FR
Johns Hopkins University School of Medicine, Baltimore, MD.
Woods
A S
AS
Griffin
M D
MD
Smith
C R
CR
Nadler
P
P
Lietman
P S
PS
D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood; D000082:Acetaminophen / Q000494:pharmacology*; D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D001241:Aspirin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007273:Injections, Intramuscular; D007372:Interferons / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000082:Acetaminophen; D007372:Interferons; D001219:Aspartate Aminotransferases; D015088:2',5'-Oligoadenylate Synthetase; D001241:Aspirin; D011241:Prednisone