[Comparative analysis of the "Meller-5" and somatic mosaicism methods with relation to the activity of standard mutagens].
The study of the genotoxic activity of ethidium bromide and bleomycin by the two methods in Drosophila melanogaster showed that both drugs possess the mutagenic activity. The comparison of the data obtained for both drugs by the methods of recessive, sex-linked, lethal mutations and somatic mosaicism indicates the quantitative and qualitative similarity of their mutagenic action. The results make it possible to regard the method of somatic mosaicism as a promising test for primary evaluation of mutagenic properties of chemical compounds.
Belova
L L
LL
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D001761:Bleomycin / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster; D004996:Ethidium / Q000633:toxicity; D005069:Evaluation Studies as Topic; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D008040:Genetic Linkage / Q000187:drug effects; D008297:Male; D009030:Mosaicism / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation
D009153:Mutagens; D001761:Bleomycin; D004996:Ethidium
Sravnitel'nyĭ analiz chuvstvitel'nosti metodov "Meller-5" i somaticheskogo mozaitsizma po otnoshenniiu k aktivnosti standartnykh mutagenov.