[Infarct-typical changes in the electrocardiogram following chemotherapy with vinblastine].
Left-chest pain and infarct-like ECG changes occurred in a 47-year-old man who had had an orchiectomy for embryonic carcinoma of the testes and was receiving the second cycle of chemotherapy with vinblastine, bleomycin and cisplatin. Only creatine kinase was slightly elevated (90 U/l) among the heart-specific enzymes. Coronary angiography did not demonstrate any coronary abnormalities, but the ventriculogram showed apical akinesia. Chest pain and similar ECG changes again occurred during the third treatment cycle, this time without bleomycin. This sequence would suggest that vinblastine was the cause of the myocardial damage, although its pathogenesis is uncertain.
Zeymer
U
U
Medizinische Klinik II, Städtische Kliniken Kassel.
Neuhaus
K L
KL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004562:Electrocardiography; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000628:therapy; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000150:complications / Q000628:therapy; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects*
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin
Infarkttypische Veränderungen im Elektrokardiogramm nach Chemotherapie mit Vinblastin.