I-J+ suppressor cells are probably involved in regulation of spleen colony formation by hematopoietic stem cells (CFUs).
Treatment of murine bone marrow and spleen cell suspensions with anti-I-Jk alloantiserum and complement resulted in an increased number of CFUs (revealed by Till and McCulloch exocolonization technique) compared with controls. The stimulatory effect was observed with 7-8 day CFUs and was negligible or absent with 11-12 day CFUs. Normal thymus cells treated with anti-I-Jk antiserum plus complement would augment the colony-forming potential of normal marrow cells.
Sanin
A V
AV
Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences, Moscow, USSR.
D000818:Animals; D001854:Bone Marrow Cells; D003165:Complement System Proteins / Q000276:immunology; D000939:Epitopes; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D051379:Mice; D013154:Spleen / Q000166:cytology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C043911:I-J-antigen; D007106:Immune Sera; D003165:Complement System Proteins