Expression of blood group antigen-related carbohydrates by human gingival epithelia.
A panel of monoclonal antibodies was used to examine differentiation-related carbohydrate structures on the surfaces of gingival epithelial cells. The patterns of binding observed indicate distinct differences in the expression of the epitopes examined for three regions of the gingival epithelia corresponding approximately to the regions defined anatomically as the junctional, oral sulcular and oral epithelia. However, epithelium with the staining pattern of oral sulcular epithelium consistently extended beyond the sulcular region to cover the gingival crest and often the uppermost part of the oral aspect of the gingiva. Differential staining of basal and suprabasal cells indicated an unusual pattern of differentiation of the junctional epithelium. The phenotype of this epithelium appears to differ from patterns reported for any other oral epithelium and the possible functional significance of this difference is discussed.
Mackenzie
I C
IC
Dabelsteen
E
E
Mandel
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U
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001789:Blood Group Antigens; D002241:Carbohydrates / Q000276:immunology*; D002454:Cell Differentiation; D004846:Epithelial Attachment / Q000166:cytology / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005881:Gingiva / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007983:Lewis Blood Group Antigens; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D001789:Blood Group Antigens; D002241:Carbohydrates; D007983:Lewis Blood Group Antigens