Acute-phase response of angiotensinogen in rat adjuvant arthritis.
The plasma level of angiotensinogen during the chronic phase of inflammation was studied for comparison with those of other acute-phase reactants in rat adjuvant arthritis. In response to a single injection of Freund's complete adjuvant, this level exhibited a transient increase during the first 24 h. By contrast, increased levels of plasma T-kininogen and alpha 2-macroglobulin, typical acute-phase reactions in the rat, were maintained during the 4-week experimental period. These results suggest that the hepatic synthesis of angiotensinogen is stimulated only in the early phase of chronic inflammation, and therefore that the mechanism underlying the acute-phase response of angiotensinogen is distinct from those currently suggested for other acute-phase reactants.
Okamoto
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Hanaoka
M
M
Yayama
K
K
Ohtani
R
R
Itoh
N
N
D000210:Acute-Phase Reaction / Q000097:blood*; D000808:Angiotensinogen / Q000097:blood*; D000818:Animals; D001168:Arthritis / Q000097:blood*; D001169:Arthritis, Experimental / Q000097:blood*; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D007249:Inflammation / Q000097:blood*; D007704:Kininogens / Q000097:blood; D008297:Male; D051381:Rats; D000511:alpha-Macroglobulins / Q000378:metabolism
D007704:Kininogens; D000511:alpha-Macroglobulins; D000808:Angiotensinogen; D003345:Corticosterone