title: Single or repeated administrations of SCH 23390 fail to affect serotonergic neurotransmission.
abstract: In synaptic membrane preparations from the frontal cortex of rats treated with single or repeated administration of mianserin or methysergide (10 mg/kg i.p.) the number of 5-HT2 receptors was reduced. In contrast, single (0.1 mg/kg or 5 mg/kg i.p.) or repeated administration of SCH 23390 (0.05 mg/kg i.p. twice daily for 3 weeks) failed to change the kinetic characteristics of 5-HT2 receptors. Moreover, in several cerebral areas, 5-HT levels and turnover were not modified by any treatment. Although SCH 23390 has a high affinity for cerebral 5-HT2 receptors, and there are conflicting data on the antagonistic activity in the periphery, our data show that doses which selectively affect dopaminergic transmission are devoid of serotonergic effects.
authors: Institute of Pharmacology, University of Bologna, Italy.
authors: O
authors: O
authors: Gandolfi
authors: P
authors: P
authors: Roncada
authors: R
authors: R
authors: Dall'Olio
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D008803:Mianserin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects*; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D001552:Benzazepines; D011985:Receptors, Serotonin; D008803:Mianserin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007650:Ketanserin; D008784:Methysergide