title: [Antigenic drift of epidemic strains of influenza A virus (H3N2) in 1985].
abstract: The study included 230 strains of influenza A (H3N2) virus isolated in the epidemic of 1985. A high degree of heterogeneity of the virus population was established with polyclonal sera, monoclonal antibodies and the method of kRNA-bRNA hybridization for the determination of the genome composition. Among the strains of one epidemic (1985) three antigenically heterogenous groups of strains were detected similar with reference A/Philippines/2/82, A/Ken/1/84, and A/Mississippi/1/85 strains. It was shown that in the process of antigenic drift in some strains there occurred a reversion of the antigenic determinants similar to those of previously circulating epidemic A/Texas/1/77 strain.
authors: M A
authors: MA
authors: Iakhno
authors: V A
authors: VA
authors: Isachenko
authors: S S
authors: SS
authors: Iamnikova
authors: A I
authors: AI
authors: Klimov
authors: V M
authors: VM
authors: Zhdanov
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology*; D004196:Disease Outbreaks; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D006389:Hemagglutinins, Viral / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D009693:Nucleic Acid Hybridization; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000382:microbiology*; D051381:Rats
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral
vernacular_title: Antigennyĭ dreĭf épidemicheskikh shtammov virusa grippa A (H3N2) 1985.