[Chemoluminescence study of the influence of phagocytosis of peripheral blood leukocytes using a perfluorocarbon-containing blood substitute].
In an animal experimental model (rats) the influence of which model substances for blood substitution of GDR origin may have on the phagocytosis behaviour of leukocytes of the peripheral blood was investigated by means of luminol-amplified chemoluminescence. After applying the model substance in an amount corresponding to 10% of the circulating blood volume a reversible increase of luminol-amplified chemoluminescence could be observed. The values referred to the portion of neutrophilic granulocytes, however, showed no significant differences compared to the control groups. The opsonizing capacity of the serum towards cymosan revealed a temporary deficit after applying blood substitution substances of GDR origin. The conclusion is drawn that the functions of leukocytes of the peripheral blood recorded by the applied method are not depressed by the model substances used.
Griepentrog
T
T
Militärmedizinische Akademie, Bad Saarow, DDR.
Wulf
E
E
Lederer
S
S
Wulf
B
B
Reichelt
H
H
D000818:Animals; D001802:Blood Substitutes; D005466:Fluorocarbons; D007962:Leukocytes / Q000032:analysis*; D008163:Luminescent Measurements; D010587:Phagocytosis; D051381:Rats
D001802:Blood Substitutes; D005466:Fluorocarbons
Chemolumineszenzuntersuchungen zur Beeinflussung der Phagozytose der Leukozyten des periphern Blutes durch perfluorcarbonhaltige Blutersatzmittel.