Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects during upper respiratory tract infection.
We studied substance P (SP)-induced cough in normal subjects without and with colds, and the effects of orally administered procaterol on SP-induced cough in normal subjects with colds. SP aerosols caused cough at a concentration of approximately 10(-15) M in subjects with colds whereas it did not cause cough at a concentration of up to 10(-5) M in subjects without colds. Procaterol (50 micrograms) completely inhibited SP-induced cough in normal subjects with colds. These results suggest that cough response to SP remarkably increases during colds and that beta-2 stimulant may be a useful tool for treatment of cough during colds in normal subjects.
Katsumata
U
U
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Sekizawa
K
K
Inoue
H
H
Sasaki
H
H
Takishima
T
T
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D017265:Procaterol; D012141:Respiratory Tract Infections / Q000503:physiopathology*; D013373:Substance P
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D013373:Substance P; D017265:Procaterol