title: Long-term follow-up after relapses in children with Hodgkin's disease.
abstract: In the years 1969-1980, 68 children with Hodgkin's disease were subjected to a combined MVPP and radiotherapy. Remissions were obtained in 64 patients, and relapses occurred in 11 children. The treatment of relapse consisted in administration of B-DOPA alone or alternatively with MVPP combined with radiotherapy (in 7 out of 11 patients). The patients were recycled every 2-3 weeks which, with other modifications of chemotherapy, allowed for the completion of the six first cycles within the period of 4,5 to 7 months. A relapse caused death of one child, and two others demonstrated further relapses. At present eight children have been showing disease-free survival following a relapse for the period of 29+ to 152+ (median, 94.5 months). The authors concluded that in patients with relapses of Hodgkin's disease the decisive role rests upon aggressive chemotherapy (high frequency of cycles).
authors: Department of Haematology, N. Copernicus University School of Medicine, Cracow, Poland.
authors: J
authors: J
authors: Armata
authors: A
authors: A
authors: Moryl-Bujakowska
authors: R
authors: R
authors: Cyklis
authors: W
authors: W
authors: Balwierz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction