Thrombin induces endothelium-dependent relaxation of pig coronary arteries.
At nanomolar concentrations, the proteolytic enzyme thrombin caused a reversible concentration-dependent relaxation of PGF2 alpha-precontracted pig coronary artery ring segments with intact endothelium. After mechanical removal of the endothelium both thrombin- and bradykinin-induced relaxation disappeared. The thrombin-induced relaxation was inhibited by the tightbinding inhibitor hirudin in a concentration-dependent manner.
Glusa
E
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Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D015237:Dinoprost / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D013552:Swine; D013917:Thrombin / Q000494:pharmacology*
D015237:Dinoprost; D013917:Thrombin