title: von Willebrand factor is an acute phase reactant in man.
abstract: Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.
authors: Section of Vascular Biology, MRC Clinical Research Centre, Harrow, U.K.
authors: B E
authors: BE
authors: Pottinger
authors: R C
authors: RC
authors: Read
authors: E M
authors: EM
authors: Paleolog
authors: P G
authors: PG
authors: Higgins
authors: J D
authors: JD
authors: Pearson
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000097:blood*; D010850:Picornaviridae Infections / Q000097:blood; D012229:Rhinovirus; D013997:Time Factors; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D000209:Acute-Phase Proteins; D014841:von Willebrand Factor; D002097:C-Reactive Protein