Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation.
The presence of intercellular adhesion molecule-I (ICAM-I) on keratinocytes of psoriatic skin lesions before and during 8-methoxapsoralen and UVA light (PUVA) treatment was studied. ICAM-I was expressed on the keratinocytes in biopsies of the skin lesions of five patients with psoriasis. The patients who responded to PUVA treatment had a concurrent reduction of ICAM-I expression on the keratinocytes with a reduction of the number of cells in the mononuclear cellular infiltrate and a lessening of the severity of the disease. Patients who went into remission during therapy and then relapsed showed an increase in ICAM-I expression on keratinocytes with an increase in the number of cells in the mononuclear cell infiltrate and an increase in the severity of the disease. HLA-DR expression on keratinocytes was variable during treatment and showed no strong correlation with disease severity.
Lisby
S
S
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Ralfkiaer
E
E
Rothlein
R
R
Vejlsgaard
G L
GL
D000954:Antigens, Surface / Q000032:analysis*; D015815:Cell Adhesion Molecules; D004817:Epidermis / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007633:Keratins; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*; D013997:Time Factors
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D006684:HLA-DR Antigens; D007633:Keratins