title: A putative homoeolog of human chromosome 12 in the owl monkey.
abstract: Analyses of Southern blots of rodent x owl monkey somatic cell hybrids permitted syntenic assignment of gene loci coding for triosephosphate isomerase (TPI), antigen CD4(T4), Kirsten rat sarcoma 2(KRAS2) virus, insulin-like growth factor 1 (IGF1), and alpha 2-macroglobulin (A2M) to chromosome 10 of owl monkey karyotype VI(2n = 49, 50). In addition, regional in situ localization of the T4 and KRAS2 loci on the proximal region of the long arm of this acrocentric chromosome and on the corresponding homologous region on the long arm of metacentric chromosome 1 of karyotype IV (2n = 52) substantiated our hypothesis that a single fusion or fission event is responsible for the polymorphism in chromosome number characteristic of owl monkeys from at least three allopatric populations. The study supports a putative homoeology between owl monkey chromosome 10 (K-VI) and human chromosome 12. The morphological differences between these two primate chromosomes indicate evolutionary rearrangements involving at least one pericentric inversion.
authors: New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
authors: N S
authors: NS
authors: Ma
authors: T S
authors: TS
authors: Harris
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D001029:Aotus trivirgatus / Q000235:genetics*; D015139:Blotting, Southern; D002427:Cebidae / Q000235:genetics*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D007708:Kirsten murine sarcoma virus / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009856:Oncogene Proteins, Viral / Q000235:genetics; D012377:Rodentia; D014305:Triose-Phosphate Isomerase / Q000235:genetics; D000511:alpha-Macroglobulins / Q000235:genetics
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D005819:Genetic Markers; D009856:Oncogene Proteins, Viral; D000511:alpha-Macroglobulins; D007334:Insulin-Like Growth Factor I; D014305:Triose-Phosphate Isomerase