[The nature of the antigenic restructuring of tumors of the human prostate].
An immunochemical study of normal prostatic tissue, adenoma and cancer identified the following five antigens: alpha 2-ferroprotein, tissue gamma-esterase, lactoferrin, acidic phosphatase and prostatic beta-globulin. The two latter proteins proved organo-specific prostatic antigens. Levels of all the proteins were measured in normal, adenoma and cancer tissues. A sharp drop in the concentration of organospecific proteins was observed in tumor tissue. The study established a relationship between the level of organospecific proteins and cell differentiation of cancer, which was particularly pronounced for beta-globulin.
Nikolaev
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AA
D000236:Adenoma / Q000276:immunology*; D000940:Antigenic Variation; D000941:Antigens / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male; D011467:Prostate / Q000276:immunology; D011470:Prostatic Hyperplasia / Q000276:immunology; D011471:Prostatic Neoplasms / Q000276:immunology*
D000941:Antigens; D000951:Antigens, Neoplasm
Kharakter antigennoĭ perestroĭki opukholeĭ predstatel'noĭ zhelezy cheloveka.