Stimulation of RNA synthesis in brain cortex of rats after hypoxia by transplantation of embryonic nervous tissue.
Our early studies (Polezhaev and Alexandrova, 1986) have shown that acute hypoxic hypoxia in rats causes mass (up to 36%) diffuse dystrophy of brain cortex neurons and that after transplantation of embryonic nervous tissue (ENT) into the brain of hypoxia-exposed rats the dystrophy and death of cortical neurons are reduced to 25% due to normalization of a part of dystrophic neurons. In the present work we studied changes in the RNA synthesis in neurons and in the total brain cortex of rats after hypoxia and subsequent transplantation of ENT into their brain by the autoradiographic and biochemical methods using 14C-adenine. It has been shown that under the action of hypoxia the RNA synthesis in neurons and in the total brain cortex of rats is reduced and after transplantation of ENT into the brain of these rats the RNA synthesis is stimulated and normalized both in neurons and in the total brain cortex.
Polezhaev
L V
LV
N. I. Vavilov Institute of General Genetics, USSR Academy of Sciences, Moscow.
Saburina
I N
IN
Cherkasova
L V
LV
Vitvitsky
V N
VN
Timonin
A V
AV
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D009417:Nerve Tissue / Q000196:embryology / Q000637:transplantation*; D009474:Neurons / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D012313:RNA