Microvascular anastomosis using polyethylene glycol 4000 and fibrin glue.
Rat femoral arteries and veins were anastomosed using fibrin glue and a soluble intravascular stent made of polyethylene glycol 4000 (PEG-4000) with a patency rate of 100%. The anastomoses were strong enough to tolerate a pressure of 250 cm H2O. Histological changes at anastomosed sites and toxicity of PEG-4000 were also examined. With this method, an end-to-end anastomosis can be performed easily and quickly.
Kamiji
T
T
Department of Dermatology, Osaka University School of Medicine, Japan.
Maeda
M
M
Matsumoto
K
K
Nishioka
K
K
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D007611:Aprotinin; D001808:Blood Vessels / Q000033:anatomy & histology; D004338:Drug Combinations; D005176:Factor XIII; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D008866:Microsurgery / Q000379:methods*; D011092:Polyethylene Glycols / Q000633:toxicity; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin; D014014:Tissue Adhesives; D014656:Vascular Surgical Procedures / Q000379:methods*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D011092:Polyethylene Glycols; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin