Granulocytic sarcoma: misleading immunohistological staining with MT1 and S100 protein antibodies.
Tissue from two patients with granulocytic sarcomas stained positively for MT1 and S100 protein antibodies; both of these cases presented considerable clinical and histological diagnostic difficulties until acute myeloblastic leukaemia spread to the bone marrow. Tissues from a further eight patients with granulocytic sarcoma were also examined retrospectively. Seven of them stained for MT1 and four for S100 protein but the traditional histological markers for myeloid cells--chloroacetate esterase and lysosyme--often stained only weakly and focally. This pattern of staining should raise the possibility of a granulocytic sarcoma in otherwise problematic cases.
Elliott
C J
CJ
Department of Histopathology, Royal Marsden Hospital, Surrey.
McCarthy
K P
KP
Carter
R L
RL
Davies
P
P
D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis*; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis*; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D009418:S100 Proteins