[The liver--an immunologically privileged organ?].
Some rat strains permanently accept allogenic livers without pharmacological immune suppression. In the same donor/recipient combinations, other organs as heart, kidney or skin are normally rejected. The transplanted liver not only withstands its own rejection, but also induce donor-specific immune tolerance. The mechanisms responsible for this effect may be clonal deletion, activation of suppressor cells or immune suppressive circulating factors as anti-class II-antibodies. An "immune-privilege" of an orthotopically transplanted liver exists also in pigs and, however to a lesser extent, in other large mammalian species including man. Regeneration of liver tissue altered by the transplantation procedure may produce the signals for induction of tolerogenic mechanisms.
Jahr
H
H
Klinik und Poliklinik für Chirurgie des Bereichs Medizin (Charité), Humboldt-Universität zu Berlin.
Wolff
H
H
D000818:Animals; D004285:Dogs / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D007108:Immune Tolerance; D008099:Liver / Q000276:immunology*; D008115:Liver Regeneration / Q000276:immunology; D016031:Liver Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice / Q000276:immunology; D011323:Primates / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology; D013552:Swine / Q000276:immunology; D014184:Transplantation, Homologous; D000509:alpha-Fetoproteins / Q000502:physiology
D000509:alpha-Fetoproteins
Die Leber--ein immunologisch privilegiertes Organ?