Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.
Tsioupra
K
K
University College London, Department of Genetics and Biometry.
West
L F
LF
Davis
M B
MB
Parrington
J M
JM
Delhanty
J D
JD
D000328:Adult; D001761:Bleomycin / Q000494:pharmacology; D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000032:analysis* / Q000187:drug effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
D001761:Bleomycin; D008769:Methylnitronitrosoguanidine