Residues of aminoglycoside antibiotics in eggs after medication of laying hens.
1. The transfer of aminoglycoside antibiotics into eggs was determined separately from albumen, yolk or whole egg after oral administration of dihydrostreptomycin (DHS), neomycin and spectinomycin and after an intramuscular injection of DHS. Residues were assayed by an agar plate diffusion method in cylinders with a specific test organism for each antibiotic. 2. Only DHS, administered by the intramuscular route, led to detectable residues in eggs. The total amount of DHS excreted via the eggs represented 1% of the dose administered. 3. Residues in the whole egg were detected for 8 d.
Roudaut
B
B
Ministère de l'Agriculture Direction Générale de l'Alimentation Services Veterinaires, Laboratoire National des Médicaments Vétérinaires, Fougères, France.
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000493:pharmacokinetics; D002645:Chickens / Q000378:metabolism / Q000502:physiology*; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D004350:Drug Residues / Q000032:analysis*; D004529:Egg White / Q000032:analysis; D004530:Egg Yolk / Q000032:analysis; D004531:Eggs / Q000032:analysis*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D009355:Neomycin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D010058:Oviposition; D000198:Spectinomycin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D000198:Spectinomycin; D009355:Neomycin; D004096:Dihydrostreptomycin Sulfate