title: Respiratory-dependent atrial pacing, management of sinus node disease.
abstract: The effectiveness of respiratory-dependent atrial pacing (AAI-RD) was assessed in 23 patients (11 male, 12 female; 68 +/- 10 years) with symptomatic isolated sinus node disease (SND). Follow-up was performed at 3 month intervals and included history taking, physical examination, ECG recording and 24-hour Holter monitoring. An incremental treadmill exercise test was performed in 21/23 patients before pacemaker implantation, in 23/23 patients after implantation (at least two tests with different programmed settings of respiratory rate/paced rate ratio); 21/23 patients underwent treadmill tests during both fixed rate 70 bpm and AAI-RD pacing. Physiological sensitivity of AAI-RD pacing was found excellent in 34 tests (85%) and fair in six (15%). Spontaneous heart rate was significantly higher after pacemaker implantation (bpm 115 +/- 20 vs 98 +/- 24, P less than 0.001). In 10/21 patients paced rate was significantly higher during AAI-RD vs AAI pacing (131 +/- 9 vs 106 +/- 16, P less than 0.001) with better total work time (min 9.9 +/- 4 AAI-RD vs 6.8 +/- 2.6 AAI, P less than or equal to 0.002), higher oxygen consumption at anaerobic threshold (ml/min 1137 +/- 406 AAI-RD vs 882 +/- 268 AAI-RD vs 5.5 +/- 2.6 AAI, P = 0.001). No significant difference was found in 7/21 patients (overlap between spontaneous and paced rate during both AAI-RD and AAI programming); 4/21 patients did not reach anaerobic threshold owing to osteomuscular limitations. AV block was detected in 1/23 patients, Biorate circuital failure in 1/23, sporadic undersensing in 5/23, short and symptom-free myopotential inhibitions in 10/23.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Divisione di Cardiologia, Ospedale Maggiore della Carità, Novara, Italy.
authors: G
authors: G
authors: Rognoni
authors: L
authors: L
authors: Bolognese
authors: F
authors: F
authors: Aina
authors: E
authors: E
authors: Occhetta
authors: A
authors: A
authors: Magnani
authors: P
authors: P
authors: Rossi
mesh_terms: D000368:Aged; D001146:Arrhythmia, Sinus / Q000628:therapy*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D010138:Pacemaker, Artificial; D005082:Physical Exertion; D012119:Respiration; D012804:Sick Sinus Syndrome / Q000628:therapy*; D013997:Time Factors