title: Ro/SS-A and the pathogenic significance of its antibodies.
abstract: Ro/SS-A is a soluble cellular protein to which antibodies are frequently directed in patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE)-related disorders. The pathogenic significance of these antibodies is uncertain. Our effort to further characterize the immunological and structural nature of Ro/SS-A suggests that the native human Ro/SS-A molecule is not glycosylated and consists of two disulfide linked domains. The amino terminus of the smaller domain contains a major epitope reactive with anti-Ro/SS-A sera. We have isolated and characterized a complementary DNA (cDNA) clone which encodes the Ro/SS-A polypeptide. The Ro/SS-A gene does not appear to be highly polymorphic and exists as a single copy on the short arm of chromosome 19. The isolation of the Ro/SS-A cDNA should allow for a more complete characterization of Ro/SS-A epitopes which should help further elucidate the importance of Ro/SS-A antibodies in the pathogenesis of disease.
authors: Department of Dermatology, U.T. Southwestern Medical Center, Dallas, Texas.
authors: D P
authors: DP
authors: McCauliffe
authors: F A
authors: FA
authors: Lux
authors: T S
authors: TS
authors: Lieu
authors: I
authors: I
authors: Sanz
authors: J
authors: J
authors: Hanke
authors: M M
authors: MM
authors: Newkirk
authors: M J
authors: MJ
authors: Siciliano
authors: R D
authors: RD
authors: Sontheimer
authors: J D
authors: JD
authors: Capra
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D004247:DNA / Q000235:genetics; D000939:Epitopes / Q000235:genetics; D005796:Genes; D006681:HLA-D Antigens / Q000032:analysis; D008178:Lupus Erythematosus, Cutaneous / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000151:congenital / Q000276:immunology; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012859:Sjogren's Syndrome / Q000276:immunology; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D004247:DNA; D000939:Epitopes; D006681:HLA-D Antigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies