[Effect of free and immobilized terrilytin on the proliferative activity of normal hepatocytes and under physical loading and exposure to vibration].
Administration of free and to a greater extent immobilized terrilytin to intact animals significantly enhanced the proliferative activity of hepatocytes and cells of the eye cornea under normal conditions, during physical loading and vibration. At administration of preparations of proteases splenocytes release two protein functionally different substances--a low molecular one exerting the immunostimulating effect and a relatively high molecular one enhancing the proliferative activity of nonimmunocompetent cells (hepatocytes and epitheliocytes of the cornea). The results of the studies indicate the presence of a close relationship between the immunological and nonimmunological effects caused by proteolytic enzymes.
Chalyĭ
G A
GA
Moralev
L N
LN
Shveĭnov
I A
IA
Laskova
I L
IL
Konoplia
A I
AI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000681:Amylases / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003315:Cornea / Q000166:cytology / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000494:pharmacology*; D007121:Immunocompetence / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D014732:Vibration / Q000009:adverse effects*
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D004800:Enzymes, Immobilized; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Vliianie svobodnogo i immobilizovannogo terrilitina na proliferativnuiu aktivnost' gepatotsitov v norme, pri fizicheskoĭ nagruzke i vibratsionnom vozdeĭstvii.