Preoperative use of 5-fluorouracil to reduce operative bleeding in transurethral resection of prostate.
We report results of a preliminary study on the preoperative use of 5-fluorouracil (5-FU) to reduce bleeding in transurethral resection of prostate. The average amount of blood lost for each case in the 5-FU group (30 cases) was calculated to be 10.16 mL/g, while the average for the control group was 15.12 mL/g. A blood loss of about 5 mL/g in the 5-FU group was less than in the control group. In addition, the reduction of bleeding was apparent in cases where the removed prostate weighed more than 10 g, and was especially marked in those cases where the removed prostate weighed 20-29 g. A pathologic examination of the 5-FU-treated prostate revealed atrophy of the glandular tissue, hyperplasia of the connective tissue, marked dilatation of the lumen of some of the acini which indicated exhaustion of glandular secretion, a decrease in the number of blood vessels, and formation of lymphoid follicles. All of the test group, with the exception of one whose white blood cell count once dropped to 2,700/mm3, did not show any side effects.
Yang
O B
OB
Department of Urology, First Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.
Cheng
J Y
JY
D000368:Aged; D005472:Fluorouracil / Q000627:therapeutic use*; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery*; D011897:Random Allocation
D005472:Fluorouracil