Multi-agent chemotherapy in combination with fractioned radiation therapy for advanced carcinoma of the cervix: acute toxicity.
Five patients with advanced, previously untreated squamous cell carcinoma of the cervix were treated with combination chemotherapy (cisplatin, mitomycin C, and bleomycin) while undergoing daily fractioned radiation therapy to cover all known disease. All patients exhibited complete clinical responses at the time of the completion of external radiation therapy. Toxicities encountered were mild. This regimen deserves further study in patients with advanced squamous cell carcinoma of the cervix.
Gordon
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AN
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Lynch
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GR
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D002945:Cisplatin / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000628:therapy*; D014750:Vincristine / Q000009:adverse effects
D001761:Bleomycin; D014750:Vincristine; D002945:Cisplatin