[A comparison of the sialyl SSEA-1 antigen and CEA in the histology of malignant mesothelioma, with special reference to adenocarcinoma of the lung].
Tumor tissues obtained from 5 cases of malignant mesothelioma and from 5 cases of primary adenocarcinoma of the lung have been studied on staining with the sialyl SSEA-1 antibody by the PAP method. Results in all cases of a malignant mesothelioma (both Epithelioid and Sarcomatous pattern) were absolutely negative. All cases of lung cancer, however, were positive, though in differing degrees. In evaluating a malignant mesothelioma, many reports have indicated that the negativity of CEA staining is useful in achieving the differential diagnosis from lung cancer. The sensitivity of the staining by sialyl SSEA-1 was found to be far better than that of CEA in examining either malignant mesothelioma or lung cancer. Thus, we found that not only CEA but also sialyl SSEA-1 antigen staining was useful for the diagnosing of a malignant mesothelioma.
Kishimoto
T
T
Dept. of Clinical Investigation, Kure Kyosai Hospital.
Okada
K
K
Shimamoto
F
F
Sato
T
T
Ono
T
T
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D016256:Lewis X Antigen; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000276:immunology* / Q000473:pathology; D013194:Staining and Labeling / Q000379:methods
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D006017:Glycolipids; D016256:Lewis X Antigen