[Treatment of patients with retroperitoneal metastases of nonseminoma tumors of the testis].
PVB or VAB-6 combination chemotherapy was given to 41 funicular orchiectomized cases of unresectable retroperitoneal metastases of nonseminoma testicular tumors. Seven of them also revealed metastases to the lung. Complete regression of retroperitoneal metastases was observed in 7 and greater than 50% regression--in 20 cases. Six patients showed complete regression of pulmonary lesions. Chemotherapy raised an opportunity for retroperitoneal lymphadenectomy in 31 cases. Lung metastasis was also removed in one patient. Following chemotherapy, histological examination failed to detect metastases in 17 cases, differentiated teratoma elements were found in 6, while tumor cells were identified in the remaining patients. Three-year survival rate for radically treated patients was 55.5% (m = 8.9). Long-term results were shown to depend mainly on the effectiveness of chemotherapy.
Matveev
B P
BP
Figurin
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KM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D009919:Orchiectomy; D011300:Preoperative Care; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D013085:Spermatic Cord / Q000601:surgery; D013724:Teratoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D013736:Testicular Neoplasms / Q000401:mortality / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D003609:Dactinomycin; D014747:Vinblastine; D003520:Cyclophosphamide; D002945:Cisplatin
Lechenie bol'nykh s zabriushinnymi metastazami neseminomnykh opukholeĭ iaichka.