title: [Inhibitory effect of AA-673 eye drops on ocular provocation for Japanese cedar pollinosis].
abstract: The inhibitory effect of 0.25% AA-673 eye drops on histamine release in tears was examined by an ocular provocation test with antigen in 11 patients with Japanese cedar pollinosis during the off-season. AA-673 eye drops were administered into the right eye, while the left eye was given placebo eye drops. Five minutes later, a cedar antigen solution at 1:20 w/v was applied to the eyes. Levels of histamine in collected tears were determined by radioimmunoassay. Histamine levels in tears before, and 5 min and 10 min after provocation amounted to 0.2 +/- 0.2 ng/ml, 1.2 +/- 1.3 ng/ml and 1.3 +/- 1.6 ng/ml, respectively, while they were 0.2 +/- 0.2 ng/ml, 3.4 +/- 2.4 ng/ml and 3.6 +/- 3.6 ng/ml in the placebo-treated eyes at the same time points, showing a significant inhibitory effect of the drug on histamine release in the eyes treated with AA-673 (p less than 0.01 at 5 min; p less than 0.05 at 10 min). Inhibition rates of AA-673 eye drops on histamine release were 73.0% at 5 min and 69.6% at 10 min after provocation, indicating the excellent effect of this preparation in inhibiting histamine release. From the above findings it is considered that 0.25% AA-673 eye drops are an effective new therapeutic agent for Japanese cedar pollinosis.
authors: Y
authors: Y
authors: Sakuma
authors: H
authors: H
authors: Mita
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000631:Aminopyridines / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000631:Aminopyridines; D009883:Ophthalmic Solutions; C045742:amlexanox