[Effect of transcription inhibitors on RNA synthesis in the polytene chromosomes of Drosophila melanogaster].
The inhibition of RNA synthesis by DRB (5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole) differs in different regions of D. melanogaster polytene chromosomes. In the majority of regions RNA synthesis is greatly inhibited, but in certain regions, including different development stage-specific puffs, it is still on. A case of transcription initiation in the heat shock puffs was also found. alpha-Amanitin considerably reduced RNA transcription in the majority of nuclei but some part of the nuclei are not affected at all. A combined action of alpha-amanitin and DRB exerts a considerably higher inhibitory effect.
Vlasova
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Zhimulev
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IF
D000546:Amanitins / Q000494:pharmacology; D000818:Animals; D002875:Chromosomes / Q000187:drug effects* / Q000378:metabolism; D003864:Depression, Chemical; D004004:Dichlororibofuranosylbenzimidazole / Q000494:pharmacology; D004331:Drosophila melanogaster; D007814:Larva; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects*; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D000546:Amanitins; D014316:Tritium; D004004:Dichlororibofuranosylbenzimidazole; D012313:RNA; D014529:Uridine
Vliianie ingibitirov transkriptsii na sintez RNK v politennykh khromosomakh Drosophila melanogaster.