Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells.
T cell vaccination against experimental autoimmune disease is herein shown to be mediated in part by anti-ergotypic T cells, T cells that recognize and respond to the state of activation of other T cells. The anti-ergotypic response thus combines with the previously shown anti-idiotypic T cell response to regulate autoimmunity.
Lohse
A W
AW
Weizmann Institute of Science, Department of Cell Biology, Rehovot, Israel.
Mor
F
F
Karin
N
N
Cohen
I R
IR
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007114:Immunization; D007116:Immunization, Passive; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008213:Lymphocyte Activation; D009169:Mycobacterium tuberculosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D007130:Immunoglobulin Idiotypes; D004676:Myelin Basic Protein; D003208:Concanavalin A