[Effect of neurotensin and substance P on the active state of the gastric smooth muscles].
Activating effect of neurotensin applied to muscle strips taken from fundal and antral portions of the guinea pig stomach was found to be due to depolarization of the muscle cells membrane and activation of the electrically controlled calcium channels. Activating effect of substance P seems to be associated with the activation of the chemo-controlled calcium channels as the contraction following the substance P application develops with no apparent changes in the membrane potential. Substance P increases the amplitude of the potassium contracture tonic component. The dynamics of active state of the muscle contractile element does not change under these conditions.
Shmigol'
A V
AV
Dem'ianenko
V S
VS
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009496:Neurotensin / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*
D015220:Calcium Channels; D015221:Potassium Channels; D013373:Substance P; D009496:Neurotensin
Vliianie neĭrotenzina i substantsii P na aktivnoe sostoianie gladkikh myshts zheludka.