Are coiled-coil proteins evolutionarily related?
A modification to the standard Needleman-Wunsch sequence comparison scheme is presented. In cases where high levels of sequence similarity may arise from a common structural motif, this method discriminates between common ancestry and similarity due to structural constraints alone. Use of this algorithm is illustrated with the coiled-coil motif in the cases of idealized coiled-coil sequences, intermediate filaments and reovirus hemagluttinin.
Subbiah
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Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138.
D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002417:Cattle; D003893:Desmin; D006801:Humans; D007381:Intermediate Filament Proteins; D007633:Keratins; D034882:Lamins; D016900:Neurofilament Proteins; D009687:Nuclear Proteins; D011487:Protein Conformation; D011506:Proteins; D014746:Vimentin
D003893:Desmin; D007381:Intermediate Filament Proteins; D034882:Lamins; D016900:Neurofilament Proteins; D009687:Nuclear Proteins; D011506:Proteins; D014746:Vimentin; D007633:Keratins