[Cell origin of 18 patients with non-T, non-B acute lymphoblastic leukemia].
Cell surface markers of 18 patients with non-T, non-B acute lymphoblastic leukemia (ALL) were analysed with a panel of monoclonal antibodies (McAbs) by indirect immunofluorescence. The results showed that the cells of 13/18 patients originated from immature B cell or B progenitors. The cells of 12/18 patients expressed B cell antigens (CD 19+ or CDw 40+). It was suggested that antibodies directed to these two surface markers could help each other in the diagnosis of ALL of B cell origin. Diagnosis might be further improved if anti-CD19 and CDw 40 McAb be used at the same time. CD 9 antigen was expressed on immature B cell surface. 13/14 patients with B-CLL did not react with anti-CD 9, but 14/18 with non-T, non-B ALL were positive. Cells of 7/18 patients expressed CALLA (CD 10), HLA-DR and CD 19/CDw 40, but did not express T cell associated antigens (CD1, CD2, CD3, CD7), so CALLA(+)-ALL also belongs to B cell lineage.
Tang
M H
MH
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis*; D019013:CD40 Antigens; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; D014408:Biomarkers, Tumor; D019013:CD40 Antigens