Clinical use of nonautologous fibrin glue.
Nonautologous, highly concentrated human fibrinogen and clotting factors were used in the form of fibrin glue to treat three patients with varied surgical problems that were resistant to conventional treatment. Fibrin glue was used to occlude longstanding enterocutaneous fistulae, control liver hemorrhage in an alcoholic patient with coagulopathy, and perform a splenorrhaphy, following a gunshot wound to the spleen. Fibrin glue is effective in establishing hemostasis and sealing tissues; its use is a helpful adjunct in the care of surgical patients.
Kram
H B
HB
Department of Surgery, King-Drew Medical Center, Los Angeles, CA 90059.
Nathan
R C
RC
Mackabee
J R
JR
Klein
S R
SR
Shoemaker
W C
WC
D000328:Adult; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D005402:Fistula / Q000628:therapy; D006488:Hemostasis, Surgical; D006801:Humans; D007412:Intestinal Fistula / Q000628:therapy; D007579:Jejunal Diseases / Q000628:therapy; D008099:Liver / Q000293:injuries; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy; D012871:Skin Diseases / Q000628:therapy; D013154:Spleen / Q000293:injuries; D013917:Thrombin / Q000627:therapeutic use*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin