[Role of the peptidergic nerves in Hirschsprung's disease and hypoganglionosis].
The purpose of this study is to examine the role of peptidergic nerves (VIP, Substance P, Neurotensin) in Hirschsprung's disease (aganglionosis) and hypoganglionosis in relation to the normoganlionic state of the colon using a mechanographic technique in vitro. The following results were obtained. 1) Normoganglionic muscle strips demonstrated the presence of intact non-adrenergic inhibitory nerve. The activities of such nerves, however, were reduced in hypoganglionic muscle strips, and were absent in aganglionic muscle strips. 2) Peptidergic nerve activities by VIP, substance P, and Neurotensin were present in normoganglionic muscle strips, while they were reduced in hypoganglionic muscle strips, and absent in aganglionic muscle strips. 3) VIP may act as a neurotransmitter-neuromodulator of non-adrenergic inhibitory nerve, while SP and Neurotensin may act as that of non-cholinergic excitatory nerve with some direct effect on the intestinal muscle.
Tomita
R
R
First Department of Surgery, Nihon University School of Medicine, Tokyo.
Morita
K
K
Munakata
K
K
D006627:Hirschsprung Disease / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000294:innervation; D009496:Neurotensin / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D013373:Substance P / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
D018377:Neurotransmitter Agents; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin