Effect of stobadine on stimulated isolated mast cells.
Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells.
Drábiková
K
K
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Pecivová
J
J
Nosál
R
R
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D006633:Histamine Antagonists; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D002243:Carbolines; D006633:Histamine Antagonists; D003189:p-Methoxy-N-methylphenethylamine; C100106:dicarbine