title: Juvenile hyaline fibromatosis. A histologic and histochemical study.
abstract: Histochemical and routine light microscopic studies were performed in nodular skin lesions excised from one patient with juvenile hyaline fibromatosis. The lesions had different times of evolution. Recent lesions showed a high density of fibroblastlike cells embedded in an amorphous matrix of glycoproteins, hyaluronic acid, and small amounts of chondroitin sulfates A and C and of dermatan sulfate. The progressive enlargement of the lesions was due to an increase in the amount of intercellular matrix produced by the cells that progressively displayed a pattern of peripheral stratification. In the older lesions, the matrix was mainly composed by chondroitin sulfates A and C. We suggest that juvenile hyaline fibromatosis represents a disease of the connective tissue with progressive abnormal differentiation to chondroid tissue.
authors: Department of Dermatology, University Medical School of Lisbon, Hospital de Santa Maria, Portugal.
authors: A
authors: A
authors: Mayer-da-Silva
authors: A
authors: A
authors: Poiares-Baptista
authors: F
authors: F
authors: Guerra Rodrigo
authors: M
authors: M
authors: Teresa-Lopes
mesh_terms: D000423:Alcian Blue; D002675:Child, Preschool; D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure; D005350:Fibroma / Q000378:metabolism / Q000473:pathology*; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D006818:Hyalin / Q000032:analysis / Q000378:metabolism*; D010503:Periodic Acid-Schiff Reaction; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D006025:Glycosaminoglycans; D000423:Alcian Blue