[Neo-adjuvant chemotherapy of nasopharyngeal carcinoma].
11 patients with advanced nasopharyngeal carcinoma were treated by combination of radiotherapy plus neo-adjuvant chemotherapy using CDDP and PEP. 1. The primary tumor was located at postero-superior wall of the nasopharynx in 6 cases and at lateral wall in 5 cases. 2. According to TNM Classification, the tumor was classified as T1 in 1 case, T2 in 4 cases, T3 in 3 cases and T4 in 3 cases. According to Stage Grouping, the tumor was grouped as stage III in 2 cases and stage IV in 9 cases. 3. Clinical results were the following: Response rate was 82%, CR being noted in 1 case and PR in 8 cases for primary lesion. It was 70%, CR in 1 case and PR in 6 cases for lymph-node involvement. 4. 4 patients died of primary lesion and 1 patient, of distant metastasis and 1 patient, of complications. 5-year cumulative survival rate was 45.5%. 5. This treatment was effective on nasopharyngeal carcinoma up to stage IV, except for T4.
Sato
K
K
Kawaguchi
T
T
Matsuoka
H
H
Hirano
M
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D017663:Peplomycin; D012074:Remission Induction
D001761:Bleomycin; D017663:Peplomycin; D002945:Cisplatin