title: [Biochemical markers of neural tube closure defects during the second half of pregnancy].
abstract: Increasing number of amniocentesis done during the second half of gestation with indication "signe d'appel" made necessary for authors to study amniotic fluid markers in late pregnancy. Normal evolution curve must be established with samples obtained after 20 weeks gestation. Study reveals more false-negative results with AFP than before 20 weeks. AChE remains constantly positive in cases with NTD, band aspect being specific. For other malformations, AChE positivity seems inconstant, with a different aspect. Some normal gestation cases can be associated with faint AChE band.
authors: Laboratoire de Biochimie, Hôpital de la Croix-Rousse, Lyon.
authors: S
authors: S
authors: Guibaud
authors: C
authors: C
authors: Boisson
authors: A
authors: A
authors: Simplot
authors: J M
authors: JM
authors: Thoulon
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis*; D000653:Amniotic Fluid / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D016136:Spina Bifida Occulta / Q000175:diagnosis / Q000235:genetics; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase
vernacular_title: Les marqueurs biochimiques des défauts de fermeture du tube neural au cours de la deuxième moitié de la grossesse.