Prostacyclin, endothelium-derived relaxing factor and vasodilatation.
In arterial smooth muscle with normal tone or predepolarized and precontracted by noradrenaline, prostacyclin (10(-9) to 10(-6) M) effects a dose-dependent hyperpolarization and relaxation. The hyperpolarization is due to K+ channel opening. In hypoxic vasodilatation, which is likewise induced by membrane hyperpolarization, a share of 20% falls to prostacyclin and 80% to an endothelium derived hyperpolarizing factor.
Siegel
G
G
Institute of Physiology, Free University of Berlin, Germany.
Schnalke
F
F
Stock
G
G
Grote
J
J
D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000494:pharmacology* / Q000502:physiology*; D016285:Iloprost; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide; D009638:Norepinephrine / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology; D014664:Vasodilation
D001685:Biological Factors; D015221:Potassium Channels; D009569:Nitric Oxide; D011464:Epoprostenol; D000242:Cyclic AMP; D016285:Iloprost; D009638:Norepinephrine