Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.
Finch
P W
PW
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Rubin
J S
JS
Miki
T
T
Ron
D
D
Aaronson
S A
SA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002455:Cell Division; D003062:Codon; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004847:Epithelial Cells; D004848:Epithelium / Q000032:analysis / Q000378:metabolism; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D012313:RNA / Q000032:analysis; D012689:Sequence Homology, Nucleic Acid; D012867:Skin / Q000032:analysis; D014018:Tissue Distribution; D014158:Transcription, Genetic
D003062:Codon; C496453:FGF7 protein, human; C496454:Fgf7 protein, mouse; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D015345:Oligonucleotide Probes; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D012313:RNA; D004247:DNA