Detection of antigen specific circulating immune complexes in Indian kala-azar.
The sera of active and treated cases of kala-azar were tested for circulating immune complexes (CIC) by antigen-specific enzyme linked immunosorbent assay (ELISA). All (100%) of proved cases had elevated CIC; 64.3% of clinically diagnosed cases and 58.8% of treated cases were also positive for CIC. A fall in the level of CIC was observed after treatment. Detection of antigen-specific CIC may be useful in monitoring the therapeutic effect and recovery.
Srivastava
L
L
National Institute of Communicable Diseases, Delhi, India.
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000953:Antigens, Protozoan / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007194:India; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology*
D000913:Antibodies, Protozoan; D000936:Antigen-Antibody Complex; D000953:Antigens, Protozoan; D000939:Epitopes; D007136:Immunoglobulins