The effect of indomethacin on serum proteins in continuously irradiated rats.
Changes in serum albumin, A1-globulin, A1-macroglobulin, haptoglobin, hemopexin, and ceruloplasmin concentration in rats irradiated continuously with a daily dose of 2.055 Gy up to a total dose of 14.385 Gy of gamma rays after peroral indomethacin administration were followed by two-dimensional immunoelectrophoresis. The use of indomethacin evoked a beneficial response particularly in the serum concentration of albumin, A1-globulin, and A1-macroglobulin on the 21st day after irradiation. In contrast with the concentrations in the irradiated control group, protein values in rats treated with indomethacin were less reduced. We did not observed significant differences between the serum concentration of haptoglobin, hemopexin, and ceruloplasmin of irradiated, indomethacin-treated and irradiated control, up to the 58th day after irradiation.
Chlebovská
K
K
Department of General Biology, Faculty of Science, Safárik University, Kosice, Czechoslovakia.
Ahlers
I
I
Chlebovský
O
O
D000510:Alpha-Globulins / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D007123:Immunoelectrophoresis, Two-Dimensional; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects / Q000528:radiation effects; D000511:alpha-Macroglobulins / Q000378:metabolism
D000510:Alpha-Globulins; D001798:Blood Proteins; D011837:Radiation-Protective Agents; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D007213:Indomethacin