Inhibition of human immunodeficiency virus-associated reverse transcriptase by aminoacridines.
A semi-synthetic bleomycin analogue and its DNA binding moiety, an alkylamino-2-methoxy-6-chloroacridine, have been found to inhibit human immunodeficiency virus-associated reverse transcriptase. The authors have synthesized various new alkylaminoacridine derivatives. Alkylaminoacridines with basic functional groups showed the enzyme inhibitory activity with less cytotoxicity.
Atsumi
S
S
Institute of Microbial Chemistry, Tokyo, Japan.
Muraoka
Y
Y
Nogami
T
T
Hoshino
H
H
Takeuchi
T
T
Umezawa
K
K
D000609:Aminoacridines / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D006678:HIV / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors; D013997:Time Factors
D000609:Aminoacridines; D018894:Reverse Transcriptase Inhibitors