Thymus factor X (TFX) in modulation of immune and inflammatory response in chickens immunized with myelin basic protein (MBP).
The immune response measured by the level of specific anti-myelin antibodies and inflammatory process indicator-haptoglobin, were studied in chickens immunized with myelin basic protein (MBP). The histopathological changes in lymphoid organs were also investigated. The occurrence of specific anti-myelin antibodies was shown in sera of immunized animals. High level of antibodies was found in IgG class. The concentration of anti-myelin antibodies in the remaining immunoglobulin classes showed different levels. High concentration of haptoglobin (up to 2 g/l) was regularly noted in the course of allergic encephalomyelitis. All the above parameters were also evaluated in the course of experimental therapy with thymus factor X (TFX). This preparation distinctly reduced haptoglobin level in serum and had only slight effect on humoral immunity. In the course of inflammatory process plasmatic cells stimulation in the spleen was observed microscopically: this was even enhanced by the thymus hormone. The lymphoid system did not undergo any significant changes. The Harder's gland did not seem to have any influence upon the induction or therapy of MBP-induced inflammation.
Giełdanowski
J
J
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Błaszczyk
B
B
Dobryszycka
W
W
Viljanen
M
M
Katkiewicz
M
M
Turkiewicz
R
R
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000145:classification; D008213:Lymphocyte Activation / Q000187:drug effects; D004676:Myelin Basic Protein / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology; D013154:Spleen / Q000187:drug effects; D013234:Stem Cells / Q000276:immunology; D013949:Thymus Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D006242:Haptoglobins; D007136:Immunoglobulins; D004676:Myelin Basic Protein; C019108:TFX; D013949:Thymus Extracts