title: Persistent light reaction. Successful treatment with cyclosporin A.
abstract: A 53-year-old male patient who had suffered for several years from severe persistent light reaction possibly due to tribromsalan photosensitivity was treated with cyclosporin A after long-term low-dose administration of corticosteroids which had to be discontinued. PUVA therapy was impracticable due to the extraordinarily high UVA sensitivity. When cyclosporin A blood concentrations between 100 and 200 ng/ml were reached, the patient was nearly free from symptoms; the excellent clinical response was also documented by phototesting performed prior to and during therapy. Cyclosporin A may be a valuable therapeutic alternative to systemic corticosteroids for severe cases of persistent light reaction which cannot be controlled by photoprotective measures.
authors: Department of Dermatology, Hospital Vienna-Lainz, Austria.
authors: P
authors: P
authors: Duschet
authors: T
authors: T
authors: Schwarz
authors: G
authors: G
authors: Oppolzer
authors: F
authors: F
authors: Gschnait
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D003524:Cyclosporins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000188:drug therapy* / Q000276:immunology; D012458:Salicylanilides / Q000009:adverse effects; D012867:Skin / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000890:Anti-Infective Agents; D003524:Cyclosporins; D012458:Salicylanilides; C004361:tribromsalan