[Effects of cefotetan administration on acute phase reactants in patients in the field of obstetrics and gynecology].
Cefotetan (CTT) was administered to 97 patients of infections and laparotomies such as operation of abdominal cesarean section, abdominal hysterectomy and ovarian cancer section in the field of obstetrics and gynecology, and acute phase reactants (APR) in the patients were measured daily. The results obtained are summarized as follows: 1. Values of alpha 1-acid glycoprotein (alpha 1-AG), haptoglobin (Hp) and C-reactive protein (CRP) were measured as the factors of APR before and after the operation. Values of alpha 1-AG in patients before the operation were 44.04-56.62 mg/dl, and rose to high values, 85.73-116.33 mg/dl, after the operation determined on 7th day and then declined to values of 69.40-99.93 mg/dl. Hp values showed similar tendency to those of alpha 1-AG values but they were usually higher than alpha 1-AG values. Although changes in values of CRP observed also were similar, they returned more rapidly to the level before the operation then other parameters. 2. CTT was clinically effective in all the cases examined. No side effects and no abnormal findings in laboratory examinations were observed. Based on the above results, the measurement of APR values after the operation appeared to be clinically useful to indicate degrees of recovery from the operation and the occurrence of multiple infections.
Chimura
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Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
D000209:Acute-Phase Proteins / Q000097:blood*; D000328:Adult; D001424:Bacterial Infections / Q000097:blood / Q000517:prevention & control*; D002097:C-Reactive Protein / Q000097:blood; D015313:Cefotetan / Q000627:therapeutic use*; D002585:Cesarean Section; D004341:Drug Evaluation; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010051:Ovarian Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy
D000209:Acute-Phase Proteins; D006023:Glycoproteins; D006242:Haptoglobins; D015313:Cefotetan; D002097:C-Reactive Protein