title: Localization of Fc gamma receptors and complement receptors CR1 on human peripheral nerve fibres by immunoelectron microscopy.
abstract: The localization of receptors for the Fc part of IgG (Fc gamma R) and for the complement C3b/C4b components (CR1) on human peripheral nerve fibres was investigated by indirect immunoperoxidase staining of frozen nerve sections with monoclonal antibodies. Transmission electron microscopy revealed that Fc gamma R and CR1 are localized to the entire surface membrane and inner membrane (axolemma) of the Schwann cell. Myelin and axons were not stained. The presence of Fc gamma R and CR1 in human Schwann cells adds further evidence for the immunocompetence of these cells.
authors: Department of Oral Pathology and Forensic Odontology, University of Bergen, Norway.
authors: C A
authors: CA
authors: Vedeler
authors: R
authors: R
authors: Nilsen
authors: R
authors: R
authors: Matre
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis* / Q000276:immunology; D003179:Complement C3b / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D051379:Mice; D008854:Microscopy, Electron; D010525:Peripheral Nerves / Q000378:metabolism / Q000648:ultrastructure*; D011951:Receptors, Complement / Q000032:analysis* / Q000276:immunology; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000032:analysis* / Q000276:immunology; D017452:Receptors, IgG; D013194:Staining and Labeling
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D017452:Receptors, IgG; D003179:Complement C3b