title: [Urinary proteins as indicators of diabetic nephropathy].
abstract: During the last ten years, several studies proved the applicability of urinary albumin quantification in the early diagnosis of diabetic nephropathy. Owing to its high accuracy and its comparable low methodological effort, only the albumin determination was emphasised. Parallel studies of urinary protein patterns, however, using sodium dodecylsulfate-polyacrylamide gel-electrophoresis demonstrated the increased excretion of other high- and low-molecular mass proteins in different stages of diabetic nephropathy. Consequently an extension of the mere albumin assay including a macromolecular (e.g. transferrin) and a micromolecular (e.g. alpha-1-microglobulin) protein seems meaningful. According to this study, both methodological lines (combined quantitative and qualitative analysis, respectively) are useful tools in the early detection and the follow up of diabetic nephropathy.
authors: Zentrum Innere Medizin der Universität Göttingen.
authors: M H
authors: MH
authors: Weber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000652:urine; D000510:Alpha-Globulins / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000652:urine*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007677:Kidney Function Tests; D008875:Middle Aged; D011507:Proteinuria / Q000652:urine*; D014168:Transferrin / Q000652:urine
chemical_list: D000510:Alpha-Globulins; D014168:Transferrin; C016001:alpha-1-microglobulin
vernacular_title: Harnproteine als Indikatoren der diabetischen Nephropathie.