Influence of drugs on the TXA2/PGI2 balance and on the atherogenic index in myocardial ischemia in dogs.
The effect of drugs on eicosanoid production and on the development of atherogenic index was investigated in canine myocardial ischemia. Iloprost, verapamil, the trapidil derivative AR 12463 or 0.9% NaCl solution were administered 60 min after coronary artery ligation in anaesthetized dogs. Both iloprost and AR 12463 reduced the thromboxane A2/prostacyclin (TXA2/PGI2) ratio in coronary sinus plasma in comparison to controls. The atherogenic index was significantly decreased in the iloprost as well as in the AR 12463-treated group in comparison to the control group. Verapamil had no influence on the investigated parameters.
Beitz
A
A
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
Taube
C
C
Beitz
J
J
Goos
H
H
Graff
J
J
Nohring
J
J
Lindenau
K F
KF
Mest
H J
HJ
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D004285:Dogs; D011464:Epoprostenol / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D016285:Iloprost; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D012016:Reference Values; D013928:Thromboxane A2 / Q000097:blood*; D014192:Trapidil / Q000031:analogs & derivatives / Q000494:pharmacology*
D000959:Antihypertensive Agents; D015415:Biomarkers; D011743:Pyrimidines; D013928:Thromboxane A2; D011464:Epoprostenol; D014192:Trapidil; D016285:Iloprost; C053729:AR 12463