title: Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies.
abstract: The fusion gene sequence of six Newcastle disease virus escape mutants revealed that residues important for the integrity of antigenic site 1 and antigenic site 2 were located, respectively, on the F2 subunit and within the cysteine-rich domain of the F1 subunit. We further report the antibody-binding capacity of these mutants.
authors: Laboratory of Biological Chemistry, Free University of Brussels, Belgium.
authors: C
authors: C
authors: Neyt
authors: J
authors: J
authors: Geliebter
authors: M
authors: M
authors: Slaoui
authors: D
authors: D
authors: Morales
authors: G
authors: G
authors: Meulemans
authors: A
authors: A
authors: Burny
mesh_terms: D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology; D000939:Epitopes / Q000235:genetics; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D009522:Newcastle disease virus / Q000235:genetics* / Q000276:immunology; D011485:Protein Binding; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D014760:Viral Fusion Proteins