title: Efficacy of thyrotropin-releasing hormone in the treatment of cerebellar ataxia.
abstract: We report a 9-year-old girl with cerebellar ataxia in whom the administration of thyrotropin-releasing hormone was effective in the treatment of a prolonged neurologic deficit. Ataxia persisted 18 months after its acute onset of unknown origin. Concentrations of homovanillic acid and 5-hydroxy-indoleacetic acid in the cerebrospinal fluid were measured repeatedly. Changes in the 5-hydroxy-indoleacetic/homovanillic acid ratio were observed, suggesting that thyrotropin-releasing hormone improved symptoms by influencing serotonin metabolism in the central nervous system.
authors: Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
authors: Y
authors: Y
authors: Takeuchi
authors: K
authors: K
authors: Fujiwara
authors: K
authors: K
authors: Ishimura
authors: Y
authors: Y
authors: Shimada
authors: M
authors: M
authors: Ochi
authors: H
authors: H
authors: Yoshioka
authors: T
authors: T
authors: Sawada
mesh_terms: D002524:Cerebellar Ataxia / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D002648:Child; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
chemical_list: D006897:Hydroxyindoleacetic Acid; D013973:Thyrotropin-Releasing Hormone; D006719:Homovanillic Acid