Preparation and evaluation of Tc-99m hydroxyethyl starch as a potential radiopharmaceutical for lymphoscintigraphy: comparison with Tc-99m human serum albumin, Tc-99m dextran, and Tc-99m sulfur microcolloid.
Tc-99m hydroxyethyl starch (Tc-99m HES) prepared with a labeling efficiency greater than 95% was evaluated in rabbits for visualization of lymphatic channels and lymph nodes, and the findings compared with Tc-99m human serum albumin (Tc-99m HSA), Tc-99m dextran (Tc-99m DXT), and Tc-99m sulfur microcolloid (Tc-99m SMC). Tc-99m HES showed good visualization of lymphatic channels and regional nodes and it had the highest clearance rate from the injection site (p less than 0.01). Tc-99m HES showed greater uptake by the nodes than Tc-99m DXT (p less than 0.001) at 90 minutes post-injection. The concentration of Tc-99m HES in the lymphatic channels was higher than that of Tc-99m SMC at 90 minutes post-injection (p less than 0.001). Preliminary clinical studies of Tc-99m HES yielded high quality lymphoscintigrams of the leg, and the pelvic and para-aortic lymph nodes in less than 10 minutes post-injection. In addition, partially and completed obstructed lymphatics could be differentiated from normal lymphatic pathways. In conclusion, Tc-99m HES is a promising radiopharmaceutical for imaging of lymphatic channels and nodes.
Sadek
S
S
Department of Nuclear Medicine, Kuwait University, Safat.
Owunwanne
A
A
Abdel-Dayem
H M
HM
Yacoub
T
T
D000818:Animals; D003911:Dextrans; D005069:Evaluation Studies as Topic; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000138:chemical synthesis*; D007271:Injections, Intradermal; D061305:Lymphoscintigraphy; D015609:Organotechnetium Compounds / Q000138:chemical synthesis*; D011817:Rabbits; D013213:Starch / Q000031:analogs & derivatives*; D013668:Technetium Tc 99m Aggregated Albumin; D013671:Technetium Tc 99m Sulfur Colloid
D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D015609:Organotechnetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C063582:Technetium Tc 99m hydroxyethyl starch; C034146:technetium Tc 99m dextran; D013671:Technetium Tc 99m Sulfur Colloid; D013213:Starch