Rectal anastomosis with application of luminal fibrin adhesive in the rectum of dogs. An experimental study.
By performing a colorectal anastomosis, the risk of a serious clinical leakage is about 10 percent. On the basis of this, the current study described a combined fibrin adhesive-sutured anastomosis in the rectum performed with interrupted seromuscular sutures externally and fibrin adhesive in the mucosa-mucosa cleft internally. Ten dogs having combined anastomosis were compared with ten dogs having a two-layer sutured anastomosis in the rectum as a control. The median bursting strength in the rectum seven days after the operation was 280 mm Hg (range, 180 to 340 mm Hg) for the combined anastomosis and 260 mm Hg (range, 170 to 405 mm Hg) for the sutured anastomosis in the control group. Two anastomoses with two-layer sutured anastomosis had a leak demonstrated radiographically, while no leakage was demonstrated in the ten dogs with combined anastomosis. In conclusion, intraluminal applied fibrin adhesive may contribute to the security of the sutured rectum-anastomosis.
Hjortrup
A
A
Department of Surgical Gastroenterology, Bispebjerg Hospital, Copenhagen, Denmark.
Nordkild
P
P
Christensen
T
T
Sjøntoft
E
E
Kjaergaard
J
J
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D007611:Aprotinin; D004285:Dogs; D004338:Drug Combinations; D005176:Factor XIII; D005337:Fibrin; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D012007:Rectum / Q000502:physiology / Q000601:surgery*; D013536:Suture Techniques; D013718:Tensile Strength; D013917:Thrombin; D014014:Tissue Adhesives
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005337:Fibrin; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin