Iron inhibits the nonspecific tumoricidal activity of macrophages. A possible contributory mechanism for neoplasia in hemochromatosis.
Green
R
R
Department of Laboratory Hematology, Cleveland Clinic Foundation, Ohio 44106.
Esparza
I
I
Schreiber
R
R
D000818:Animals; D001052:Apoferritins / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D003864:Depression, Chemical; D006432:Hemochromatosis / Q000139:chemically induced / Q000503:physiopathology; D007372:Interferons / Q000096:biosynthesis; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D008081:Liposomes; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured
D008081:Liposomes; D007372:Interferons; D001052:Apoferritins; D007501:Iron