Interferons as gene activators: close linkage of two interferon-activatable murine genes.
Previously we have identified a mouse genomic clone (clone 5) which specifies the 5' flanking region and the 5' terminal exon of an interferon-activatable gene (202 gene). Here, we show that about 5 kb upstream from this flanking region in clone 5 there occurs a 3' terminal region of a second interferon-activatable gene (203 gene). The two genes are transcribed in the same direction. Segments from the 203 gene can be hybridized to a set of five interferon-inducible RNAs. The 203 mRNAs are induced about 15-fold in interferon-treated Ehrlich ascites tumor cells.
Engel
D A
DA
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511.
Snoddy
J
J
Toniato
E
E
Lengyel
P
P
D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D008040:Genetic Linkage; D007372:Interferons / Q000502:physiology*; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D013997:Time Factors; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D007372:Interferons