Structure of the bovine eye lens gamma s-crystallin gene (formerly beta s).
The organization of a number of crystallin genes has already been resolved. One of the remaining genes of which the structure was hitherto unknown is the gamma s gene (formerly beta s). We determined the complete sequence of the bovine gamma s-crystallin-coding gene, apart from the middle region of the first intron. Since it contains three exons and two introns, we conclude that the former beta s, also at the gene level is gamma-crystallin-like. However, it is located on chromosome 3, in contrast to other gamma genes which occur in tandem on the human chromosome 2.
van Rens
G L
GL
Department of Biochemistry, University of Nijmegen, The Netherlands.
Raats
J M
JM
Driessen
H P
HP
Oldenburg
M
M
Wijnen
J T
JT
Khan
P M
PM
de Jong
W W
WW
Bloemendal
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D002417:Cattle; D002893:Chromosomes, Human, Pair 3; D003001:Cloning, Molecular; D003198:Computer Simulation; D003459:Crystallins / Q000096:biosynthesis / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005091:Exons; D006801:Humans; D006822:Hybrid Cells; D007438:Introns; D007908:Lens, Crystalline / Q000032:analysis*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D015183:Restriction Mapping; D009626:Terminology as Topic
D003459:Crystallins; D012313:RNA; D004247:DNA