Hereditary dysfibrinogenaemia (fibrinogen Jena)--report of a family study.
A qualitative abnormality of fibrinogen was found in a boy aged 3 years and 6 months. It was recognized by prolonged prothrombin-, thrombin- and reptilase clotting times. There was also a difference between the results of different fibrinogen assays. The same constellation was identified in additional 7 members of the family belonging to 3 generations. No bleeding or thrombotic symptoms exist. The mode of inheritance of the fibrinogen variant (fibrinogen Jena) seems to be autosomal-dominant.
Maak
B
B
Childrens Hospital, University of Jena, GDR.
D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000235:genetics*; D001780:Blood Coagulation Tests; D002675:Child, Preschool; D015241:Fibrinogens, Abnormal / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
D015241:Fibrinogens, Abnormal