Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse.
Evidence is presented that expression of the two myelin-associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse.
Fujita
N
N
Department of Neurology, Niigata University, Japan.
Sato
S
S
Kurihara
T
T
Inuzuka
T
T
Takahashi
Y
Y
Miyatake
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D004247:DNA / Q000235:genetics; D003711:Demyelinating Diseases / Q000235:genetics; D005091:Exons; D051379:Mice; D008821:Mice, Quaking; D008969:Molecular Sequence Data; D009185:Myelin Proteins / Q000235:genetics*; D018992:Myelin-Associated Glycoprotein; D009693:Nucleic Acid Hybridization; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*
D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D012333:RNA, Messenger; D004247:DNA