[IgA rheumatoid factors in ankylosing spondylitis].
151 cases of ankylosing spondylitis, arranged in clinical stages I-IV, were investigated by immunological methods (determination of HLA-B27, immunocomplexes: conglutinin-, Clq-assay; IgG-, IgM-, IgA-rheumatoid factors) and with regard to acute phase proteins (CRP, C3/C4, alpha 1-acid glycoprotein). IgA-rheumatoid factors were demonstrated as dependent upon the stage of the disease in 23-41% of cases and appeared in 20-23% of cases simultaneously with immunocomplexes. Immunocomplexes appeared in 20-23% of cases. With regard to investigations of acute phase proteins, sedimentation rate and CRP correlated best. The frequent appearance of IgA-rheumatoid factors allows a definition of ankylosing spondylitis as seronegative only as far as the determination of IgG- and IgM- rheumatoid factors is concerned.
Steffen
C
C
Institut für Immunologie, Universität Wien.
Prohaska-Marchried
E
E
Zlabinger
G
G
Menzel
J
J
D000209:Acute-Phase Proteins / Q000032:analysis; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics; D015796:HLA-B27 Antigen; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis*; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology*
D000209:Acute-Phase Proteins; D000936:Antigen-Antibody Complex; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D007070:Immunoglobulin A; D012217:Rheumatoid Factor
IgA-Rheumafaktoren bei Spondylitis ankylosans.