Pharmacological characterization of conduction over a Mahaim fiber: evidence for adenosine sensitive conduction.
The presence of a nodoventricular pathway (Mahaim fiber) has been invoked to explain certain distinctive electrocardiographic and electrophysiological observations. The presence of an atrioventricular or atriofascicular fiber with decremental conduction properties has been documented in many of these patients. We report the case of a patient with a Mahaim fiber and the response to conduction over this pathway after adenosine, procainamide, encainide, verapamil, edrophonium, phenylephrine and isoproterenol. Conduction over the Mahaim fiber was blocked by adenosine, but not verapamil. The time course of adenosine induced block over the Mahaim fiber differed from adenosine induced AV nodal block. Mahaim fibers are decrementally conducting pathways that are adenosine sensitive. These findings support the concept that conduction in accessory pathways manifesting decremental properties is not mediated by the calcium channel.
Ellenbogen
K A
KA
Department of Medicine, Medical College of Virginia, Richmond.
Rogers
R
R
Old
W
W
D000241:Adenosine / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D011226:Pre-Excitation Syndromes / Q000503:physiopathology*; D011227:Pre-Excitation, Mahaim-Type / Q000503:physiopathology*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D014700:Verapamil; D000241:Adenosine