von Willebrand factor is an acute phase reactant in man.
Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.
Pottinger
B E
BE
Section of Vascular Biology, MRC Clinical Research Centre, Harrow, U.K.
Read
R C
RC
Paleolog
E M
EM
Higgins
P G
PG
Pearson
J D
JD
D000209:Acute-Phase Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000097:blood*; D010850:Picornaviridae Infections / Q000097:blood; D012229:Rhinovirus; D013997:Time Factors; D014841:von Willebrand Factor / Q000378:metabolism*
D000209:Acute-Phase Proteins; D014841:von Willebrand Factor; D002097:C-Reactive Protein