Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells.
Galanin inhibits depolarization-induced dopamine release from chromaffin cells. In excised membrane patches, galanin induced openings of a 36 pS, inwardly rectifying potassium channel. Galanin activation of this K+ channel was blocked by pretreatment with pertussis toxin. Galanin is without effect on L-type Ca2+ channels.
de Weille
J R
JR
Centre de Biochimie du Centre National de la Recherche Scientifique, Nice France.
Fosset
M
M
Schmid-Antomarchi
H
H
Lazdunski
M
M
D000818:Animals; D004298:Dopamine / Q000493:pharmacokinetics*; D019004:Galanin; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D010673:Pheochromocytoma; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D010455:Peptides; D015221:Potassium Channels; D019004:Galanin; D004298:Dopamine