[Opposite variations of extracellular concentrations of 5-hydroxyindoleacetic acid (5-HIAA) measured by voltammetry of axonal terminals and cell bodies of the dorsal raphe nucleus through the sleep-wake cycle].
Differential pulse voltammetry was used for 5-hydroxyindoleacetic acid (5-HIAA) detection in the rat caudate (n. Cd) and Raphe Dorsalis (n. RD) nuclei, in chronic experimental conditions. In the anterior and ventral part of n. RD, large increases in the extracellular concentrations of 5-HIAA were reported during slow wave sleep (SWS) and paradoxical sleep (PS) whereas a decrease occurred during waking. These variations could reflect the dendritic release of serotonin. In n. Cd, opposite variations of the extracellular concentrations of 5-HIAA were observed i.e. increase during waking state and decrease during SWS and PS.
Cespuglio
R
R
Laboratoire de Médecine expérimentale, I.N.S.E.R.M., Lyon.
Chastrette
N
N
Jouvet
M
M
D000818:Animals; D001369:Axons / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D004566:Electrodes; D005110:Extracellular Space / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline
Variations opposées des concentrations extracellulaires de l'acide 5-hydroxyindolacétique (5-HIAA) mesurées par la voltamétrie au niveau des terminaisons axonales et des corps cellulaires du noyau raphe dorsalis, à travers le cycle veille-sommeil.