Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype.
DA strain of Theiler's murine encephalomyelitis virus produces a persistent demyelinating infection. We previously produced escape mutant viruses that are resistant to a neutralizing monoclonal antibody and have a mutation in VP1 amino acid residue 268 in a neutralization site (Y. Ohara, A. Senkowski, J. Fu, L. Klaman, J. Goodall, M. Toth, and R.P. Roos, J. Virol. 62:3527-3529, 1988). In contrast to wild-type DA strain, these escape mutants produce little if any demyelinating disease after inoculation into weanling mice.
Roos
R P
RP
Department of Neurology, University of Chicago Pritzker School of Medicine, Illinois 60637.
Stein
S
S
Routbort
M
M
Senkowski
A
A
Bodwell
T
T
Wollmann
R
R
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins; D004770:Enterovirus / Q000276:immunology*; D004769:Enterovirus Infections / Q000473:pathology; D000939:Epitopes; D004680:Maus Elberfeld virus / Q000276:immunology*; D051379:Mice; D009154:Mutation; D009500:Neutralization Tests
D000911:Antibodies, Monoclonal; D036022:Capsid Proteins; D000939:Epitopes