I-J and mechanism of immunosuppression.
I-J has been found to be an inducible isomorphic molecule expressed on class II-restricted T cells. It undergoes a systematic adaptive change in radiation bone marrow chimeras according to the environmental major histocompatibility complex (MHC). Recent biochemical studies demonstrated that I-J is a homodimer of MW 84,000-90,000 composed of 42,000-46,000 MW glycopeptide subunits. The molecule is different from class II-restricted T-cell receptor, class II antigens or putative mouse CD28. The ligation of I-J molecules with anti-I-J results in the suppression of T-cell responses by the inhibition of early signal transduction through antigen recognition.
Nakayama
T
T
Department of Immunology, Faculty of Medicine, University of Tokyo, Japan.
Asano
Y
Y
Tada
T
T
D000818:Animals; D000939:Epitopes / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II; D007108:Immune Tolerance
D000939:Epitopes; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C043911:I-J-antigen