Influence of the red blood cell Ca2+-ion concentration on the erythrocyte aggregation in stasis.
Ca2+ ions were transported into the cell by incubation of the erythrocyte suspension with ionophore A23187, a lipophil electric neutral ion complexing substance. Erythrocyte aggregation could be increased twice, when doubling the intracellular Ca2+-ion concentration. Our measurements lead to the suggestion that an increase of the cytoplasmatic Ca2+ ion changes the physical and/or biochemical properties of the aggregation receptors on the membrane surface, i.e., cell-protein interactions are regulated by alteration of the intracellular Ca2+-ion concentration.
Friederichs
E
E
Department of Pediatrics, University of Göttingen, Federal Republic of Germany.
Winkler
H
H
Tillmann
W
W
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood*; D002449:Cell Aggregation; D003600:Cytosol / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000097:blood; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D000511:alpha-Macroglobulins / Q000032:analysis
D000511:alpha-Macroglobulins; D005340:Fibrinogen; D002118:Calcium