[Treatment of stage I-IIB nonseminomatous testicular tumors].
Data on 90 patients (median age 26 years, range 15-65) with nonseminomatous testicular tumour (NTT) were analysed retrospectively to evaluate the effectiveness of adjuvant chemotherapy: 55 patients had received postoperatively (semicastration, retroperitoneal lymphadenectomy) adjuvant chemotherapy. They have now lived tumour-free for a median period of 67 (range 8-107) months. These results were compared with a group of 35 patients with recurrence of NTT who, after the primary operation, had been merely followed-up but, on diagnosis of recurrence, had received intensive chemotherapy with removal of the recurring tumour, if indicated. Nonetheless, only 24 of these 35 patients (69%) went into a lasting remission. A favourable factor was regular follow-up examinations with early diagnosis of any recurrence. Thus in a quarter of the patients a possible curative chance was missed despite an initially low tumour stage. The results suggest that omission of operative or chemotherapeutic measures is justified only if careful followup is assured.
Clemm
C
C
Medizinische Klinik III, Universität München.
Sauer
H
H
Hartenstein
R
R
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009919:Orchiectomy; D012189:Retrospective Studies; D013736:Testicular Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide
Behandlung nicht-seminomatöser Hodentumoren im Stadium I-IIB.