Immunohistochemistry of capillary hemangioblastoma. Immunoperoxidase-labeled antibody staining resolves the differential diagnosis with metastatic renal cell carcinoma, but does not explain the histogenesis of the capillary hemangioblastoma.
We used a battery of antigens to determine whether immunohistochemistry can (a) contribute to resolving the histogenesis of the stromal component of the capillary hemangioblastoma, and (b) answer cases of difficult pathologic differential diagnosis with metastatic clear cell carcinoma. The stromal cells of the capillary hemangioblastoma are antigenically polymorphous and may express immunoreactive erythropoietin, renin, keratin, Leu M1, Leu 7, actin, neuron-specific enolase, S100 protein, and glial fibrillary acidic protein. However, the use of epithelial membrane antigen allows certain histopathologic distinction between capillary hemangioblastoma and metastatic clear cell carcinoma.
Hufnagel
T J
TJ
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510.
Kim
J H
JH
True
L D
LD
Manuelidis
E E
EE
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology / Q000556:secondary; D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000032:analysis* / Q000473:pathology / Q000556:secondary; D002528:Cerebellar Neoplasms / Q000032:analysis / Q000473:pathology / Q000556:secondary; D003937:Diagnosis, Differential; D004921:Erythropoietin / Q000032:analysis; D006394:Hemangiosarcoma / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000032:analysis* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D012083:Renin / Q000032:analysis
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; D018396:Mucin-1; D004921:Erythropoietin; D007633:Keratins; D012083:Renin