Granulocyte colony-stimulating factor: preclinical and clinical studies.
The production of neutrophil granulocytes is a complex and dynamic process during which a small number of self-renewing stem cells give rise to lineage-specific progenitors. One hematopoietic glycoprotein that appears to specifically control the survival, cycle activation, proliferation and terminal maturation of this myeloid lineage is granulocyte colony-stimulating factor (G-CSF). Some topics discussed are its molecular characterization, biochemical purification, sources, and effects of administration.
Gabrilove
J L
JL
Memorial Sloan-Kettering Cancer Center, New York, New York.
Jakubowski
A
A
D000380:Agranulocytosis / Q000188:drug therapy*; D000818:Animals; D001855:Bone Marrow Diseases / Q000188:drug therapy* / Q000209:etiology; D016026:Bone Marrow Transplantation; D003115:Colony-Stimulating Factors / Q000302:isolation & purification / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D016179:Granulocyte Colony-Stimulating Factor; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000150:complications; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D011323:Primates; D011994:Recombinant Proteins / Q000627:therapeutic use; D012377:Rodentia
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor