Plasmapheresis alleviates neuropathy accompanying IgM anti-myelin-associated glycoprotein paraproteinemia.
A patient with peripheral neuropathy accompanying a benign IgM anti-myelin-associated glycoprotein paraproteinemia has been treated successfully by plasmapheresis for over a year, and during this time, fluctuations in the patient's symptoms and signs have correlated with variations in the serum IgM level. These results suggest that plasmapheresis may be more beneficial for such neuropathies than indicated previously, and they add to the evidence implicating the paraprotein as the cause of the neuropathy.
Haas
D C
DC
Department of Neurology, State University of New York Health Science Center at Syracuse.
Tatum
A H
AH
D000328:Adult; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains; D008297:Male; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000628:therapy; D010956:Plasmapheresis
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein