Flow cytometry of normal, hyperplastic, and malignant human endometrium. A study of ploidy and proliferative indices including comparison with in vitro S-phase labeling.
The validity of 48 endometrial proliferative indices derived from flow cytometric deoxyribonucleic acid histograms was tested by comparison with S-phase labeling indices. There was a positive but weak correlation. Despite this correlation, there was a good relationship between the flow cytometric proliferative indices and both the menstrual phase and degree of tissue differentiation in a larger series of 162 normal, hyperplastic, and malignant endometrial specimens examined by flow cytometry alone. Flow cytometric proliferative indices may be useful for prediction of tumor behavior in non-DNA aneuploid endometrial carcinomas that are assessed as being a good prognostic type by other tumor parameters.
Thornton
J G
JG
Department of Obstetrics and Gynecology, University of Leeds, England.
Quirke
P
P
Wells
M
M
D002277:Carcinoma / Q000032:analysis / Q000473:pathology*; D002455:Cell Division; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D004714:Endometrial Hyperplasia / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000166:cytology* / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D011003:Ploidies; D011379:Prognosis; D013194:Staining and Labeling / Q000379:methods; D014594:Uterine Neoplasms / Q000032:analysis / Q000473:pathology*
D004273:DNA, Neoplasm; D004247:DNA