[Colony stimulating factor producing carcinoma of the pancreas--a case report].
Reported is the case of a 71-year-old male patient with a pancreatic carcinoma that showed marked leucocytosis of up to 71300/mm3. Tests revealed that the patient's granulocyte-colony stimulating factor (G-CSF) in serum was 0.65 ng/ml and 0.74 ng/ml in pleural effusion, these values almost triple the values of a normal control (0.20 in serum, 0.25 ng/ml in pleural effusion). These findings have indicated that the tumor itself was responsible for producing the inflated values of the granulocyte-colony stimulating factor. This case of a G-CSF-producing pancreatic carcinoma is discussed, along with a review of the pertinent literature.
Ohwada
S
S
2nd Dept. of Surgery, Gunma Univ. School of Med.
Miyamoto
Y
Y
Fujii
T
T
Kuribara
T
T
Teshigawara
O
O
Oyama
T
T
Ishii
H
H
Joshita
T
T
Izuo
M
M
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000378:metabolism*; D000368:Aged; D003115:Colony-Stimulating Factors / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D016179:Granulocyte Colony-Stimulating Factor; D006098:Granulocytes; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism*; D010996:Pleural Effusion / Q000378:metabolism
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor