Stress-induced changes of the noradrenergic transmitter release in adrenals and the influence of substance P.
The paper presents results about the role of Substance P (SP) in stressful situations, especially on the spontaneous and nicotine-evoked noradrenaline (3H-NA) outflow in adrenal gland slices. Chronic stress increases the spontaneous as well as the stimulated 3H-NA outflow. SP applied i.p. during stress exposure inhibits the stress-induced elevation of the spontaneous and stimulated 3H-NA outflow. Application of SP direct to the superfusion solution influences the stimulated 3H-NA outflow but it does not change the spontaneous 3H-NA outflow in adrenal gland slices of stressed rats. The data support the hypothesis that SP modulates the transmitter release in adrenals during stressful situations.
Nieber
K
K
Institute of Drug Research, Academy of Sciences of the GDR, Berlin.
Roske
I
I
Oehme
P
P
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D009638:Norepinephrine / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D009638:Norepinephrine