Synaptic interconnections among growth hormone-releasing hormone (GHRH)-containing neurons in the arcuate nucleus of the rat hypothalamus.
The existence of a growth hormone-releasing hormone (GHRH)-containing local neuronal network in the arcuate nucleus of the rat has been established on the basis of light and electron microscopic immunohistochemistry. GHRH-immunostained nerve terminals were demonstrated in synaptic contact with GHRH-immunoreactive dendrites and perikarya. These neuronal circuits may allow arcuate GHRH neurons to operate synchronously, or may provide morphological evidence for the existence of a neuronal ultrashort feedback mechanism for regulating GHRH release in the hypothalamo-hypophyseal system.
Horváth
S
S
Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Md.
Palkovits
M
M
D000818:Animals; D005246:Feedback; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D006651:Histocytochemistry; D007031:Hypothalamus / Q000648:ultrastructure*; D007120:Immunochemistry; D008297:Male; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling; D013570:Synaptic Membranes / Q000648:ultrastructure*
D013007:Growth Hormone-Releasing Hormone