title: Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production.
abstract: T-cell clones (TLC) were established from a Francisella tularensis-vaccinated subject in order to study the cells responsive for cell-mediated immunity against F. tularensis. All the clones were human leukocyte antigen (HLA) class II restricted to one of the HLA-DR specificities of the original donor. The TLC cells were CD4+ and produced interleukin-2 and gamma interferon after stimulation with specific antigen. Seven of the eight clones tested assisted in the production of immunoglobulin G (IgG), IgA, and IgM antibodies.
authors: National Public Health Institute, University of Oulu, Finland.
authors: H M
authors: HM
authors: Surcel
authors: J
authors: J
authors: Ilonen
authors: K
authors: K
authors: Poikonen
authors: E
authors: E
authors: Herva
mesh_terms: D002999:Clone Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D000939:Epitopes / Q000276:immunology; D005604:Francisella tularensis / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology
chemical_list: D000939:Epitopes; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007136:Immunoglobulins; D007376:Interleukin-2; D007371:Interferon-gamma