title: Regional differences in substance P-like immunoreactivity in the striatum correlate with levels of pre-protachykinin mRNA.
abstract: The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of the beta-preprotachykinin mRNA) were located within the boundaries of areas of dense [3H]naloxone binding which delineate the striosomes, a striatal compartment distinct from the surrounding matrix with respect to its inputs, outputs and neurochemical content. In view of previous immunohistochemical data, the results suggest that tachykinin-containing neurons of the striosomes have a higher rate of tachykinin synthesis than those neurons located in the surrounding striatal matrix.
authors: Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129.
authors: M F
authors: MF
authors: Chesselet
authors: E
authors: E
authors: Robbins
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D015320:Tachykinins / Q000378:metabolism*
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; D015320:Tachykinins; C044206:preprotachykinin; D013373:Substance P