Perivascular innervation of the mesenteric artery in spontaneously hypertensive rats.
Perivascular innervation of the mesenteric arteries of 7-week-old and 6-month-old spontaneously hypertensive rats and normotensive Wistar-Kyoto rats was examined. The densities of neuropeptide Y-containing nerve fibers and adrenergic nerve fibers were increased in the distal regions of mesenteric arteries of spontaneously hypertensive rats as compared with findings in Wistar-Kyoto rats. However, the densities of cholinergic nerve fibers, vasoactive intestinal polypeptide-containing, and substance P-containing nerve fibers in the mesenteric arteries of the spontaneously hypertensive rats were unchanged in comparison with findings in the Wistar-Kyoto rats. Thus, not only adrenergic nerve fibers but also neuropeptide Y-containing nerve fibers may play an important role in the development and maintenance of hypertension in spontaneously hypertensive rats.
Kawamura
K
K
Second Department of Pathology, School of Medicine, Fukuoka University, Japan.
Ando
K
K
Takebayashi
S
S
D000320:Adrenergic Fibers; D000818:Animals; D001794:Blood Pressure; D002799:Cholinergic Fibers; D008297:Male; D008638:Mesenteric Arteries / Q000032:analysis / Q000294:innervation*; D009478:Neuropeptide Y / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013373:Substance P / Q000032:analysis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide