[Aneuploid and diploid neoplasms of the breast and their relation to the prognosis of the disease].
Flow cytofluorometry has been used to examine the tumor ploidy in 32 patients with benign mammary tumors and 41 patients with mammary carcinomas; the relationship between the tumor ploidy and the disease prognosis has been under study. Chicken red cells whose DNA content is invariable and is almost 3 times lower were used as the inner reference sample for diploid cells. All the obtained DNA histograms of benign mammary tumors were diploid (the DNA index 1), those of malignant tumors aneuploid in 26 (63%) and diploid in 15 (37%) cases. Analysis of the late results of treatment has shown that the process progress is significantly more often in the patients with the aneuploid DNA content in the tumor cells (chi 2 = 10.2; p less than 0.01), this progress being due to delayed metastases to the lymph nodes, bones, and viscerae; the 5-year survival rate is lower (chi 2 = 4.19; p less than 0.05) than in diploid malignant tumors.
Bogatyrev
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D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D006801:Humans; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate
Aneuploidnye i diploidnye novoobrazovaniia molochnykh zhelez i ikh sviaz' s prognozom zabolevaniia.