[A new highly sensitive method of analysis of thrombocyte aggregation].
The new method for studies of the platelet aggregation kinetics is based on the creation of a platelet stream through the optic canal and on an analysis of fluctuations in the intensity of the luminous flux that has passed through the sample. The relative dispersion of fluctuations in the intensity of the light passed through the sample is suggested as a parameter for the estimation of the platelet aggregation and for analysis of their aggregation kinetics. The method permits recording the platelet aggregation in citrate plasma, enriched for platelets, after exposure to the inductor in very low concentrations (0.05-0.15 microM ADP). Scanning electron microscopy has shown that aggregates are indeed formed in such cases, and they can be recorded from the increase of the relative dispersion in the fluctuations in the passed light intensity but cannot be recorded by Born's optic method.
Gabbasov
Z A
ZA
Popov
E G
EG
Gavrilov
I Iu
IIu
Pozin
E Ia
EIa
Markosian
R A
RA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods*
D000244:Adenosine Diphosphate
Novyĭ vysokochuvstvite'lnyĭ metod analiza agregatsii trombotsitov.