Sensitivity of protein and RNA synthesis to antiamoebic drugs in axenic Entamoeba histolytica (NIH-200).
The action of antiamoebic drugs on the incorporation of (14C) 1-DL-valine and (14C)-8 adenine in TCA insoluble fraction of axenic Entamoeba histolytica was investigated. Adenine showed greater sensitivity to all the drugs tested viz. camoquin, chloroquine, diodoquin, metronidazole, entobex and diloxanide furoate except enterovioform.
Agrawal
A
A
Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
Pandey
V C
VC
Sagar
P
P
D000225:Adenine / Q000378:metabolism; D000563:Amebicides / Q000494:pharmacology*; D000818:Animals; D004748:Entamoeba histolytica / Q000187:drug effects* / Q000378:metabolism; D005856:Germ-Free Life; D014176:Protein Biosynthesis / Q000187:drug effects*; D012313:RNA / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects*; D014633:Valine / Q000378:metabolism
D000563:Amebicides; D012313:RNA; D014633:Valine; D000225:Adenine