title: Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle.
abstract: Carbonic anhydrase III (CAIII) protein and mRNA amounts in fast- and slow-twitch rat muscles were examined after resection of the sciatic nerve. Striking changes occur in the fast-twitch anterior tibialis (AT) and extensor digitorum longus (EDL) muscles, where CAIII protein and mRNA are increased several-fold 16 days after denervation. The data suggest that these changes are regulated in part by changes in gene transcription and that they perhaps signal a fast-to-slow fibre type transition in these denervated muscles. AT and EDL show some differences in the effects of denervation, which are suggestive of variation in the timing of denervation-induced responses and/or the CAIII protein/mRNA turnover rates in the two muscles.
authors: Department of Child Health, St. George's Hospital Medical School, London, U.K.
authors: N D
authors: ND
authors: Carter
authors: P J
authors: PJ
authors: Wistrand
authors: H
authors: H
authors: Isenberg
authors: H
authors: H
authors: Askmark
authors: S
authors: S
authors: Jeffery
authors: D
authors: D
authors: Hopkinson
authors: Y
authors: Y
authors: Edwards
mesh_terms: D000199:Actins / Q000096:biosynthesis; D000818:Animals; D002256:Carbonic Anhydrases / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction; D005260:Female; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D009121:Muscle Denervation; D009124:Muscle Proteins / Q000096:biosynthesis*; D009132:Muscles / Q000378:metabolism; D010455:Peptides / Q000032:analysis; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000199:Actins; D007527:Isoenzymes; D009124:Muscle Proteins; D010455:Peptides; D012333:RNA, Messenger; D012313:RNA; D002256:Carbonic Anhydrases