[The pathogenesis of glomerulonephritis in MRL mice--murine lupus erythematosus].
In a sequential study the spontaneously occurring glomerular lesions in MRL mice were analysed by light and immunofluorescence microscopy. The study was carried out with a total of 265 MRL mice of both substrains (MRL/Mp-lpr/lpr and -+/+) and of different age-groups. The glomerular lesions were classified in five forms of glomerulonephritis (GN): focal GN, diffuse GN, intra- and extracapillary-proliferative (crescentic) GN, membranoproliferative GN, and membranous GN. Crescentic GN was exclusively seen in mice of substrain lpr/lpr. Marked substrain-related differences concerning frequency, age of onset and severity of glomerular lesions were found. The occurrence of severe glomerulopathies in mice of substrain lpr/lpr at the age of 3 months was associated with a highly significant increase of circulating immune complexes.
Hewicker
M
M
Kromschröder
E
E
Trautwein
G
G
D000818:Animals; D015433:Glomerulonephritis, Membranous / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008181:Lupus Nephritis / Q000473:pathology*; D051379:Mice; D008817:Mice, Mutant Strains
Untersuchungen zur Pathogenese der Glomerulonephritis bei MRL-Mäusen--muriner Lupus erythematodes.