Effect of dietary fat on antibody response and on down-regulation.
Diets differing in the ratios of polyunsaturated to saturated fatty acids (P/S) have dramatically different effects on the extent to which pretreatment with aggregate-freed form of a foreign protein augments or diminishes (by sensitization or down-regulation) the subsequent response to an immunogenic form of the same protein. We have examined this phenomenon in terms of both down-regulation (acquired immunological tolerance) and sensitization induced in 87-week-old female C57BL/6 mice. Antibody response in these mice, fed on low P/S diets, could be down-regulated by pretreatment with aggregate-free rabbit gamma globulin, as manifested by antibody to aggregated rabbit gamma globulin of isotypes IgG3 and IgG2b. Animals fed high P/S diets were not down-regulated by the pretreatment, but were sensitized; there was a 2-3-fold increase in IgG3, IgG1, IgG2a and IgA antibody to rabbit gamma globulin.
Ponnappan
U
U
Department of Immunology, University of Toronto, Ontario, Canada.
Cinader
B
B
Clandinin
M T
MT
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D005719:gamma-Globulins / Q000276:immunology
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005719:gamma-Globulins