Correlation between tissular levels of prostatic acid phosphatase and prostate-specific antigen and hormonal response of metastatic prostatic cancer.
A correlation between the serum levels of testosterone and the tissular intensity of prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) in normal prostates has been demonstrated. In prostatic cancer patients, we studied the correlation between the percentage of neoplastic cells secreting PAP and PSA and the response to androgen deprivation, and found no relationship between them. Therefore it is not possible to predict the response to hormone therapy through the grade of tissular PAP or PSA.
Algaba
F
F
Pathology Section, Urology Service IUNA, Fundación Puigvert, Barcelona, Spain.
Chéchile
G
G
Zungri
E
E
D000135:Acid Phosphatase / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000628:therapy; D013739:Testosterone / Q000097:blood
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D013739:Testosterone; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen