Globular changes in cytomegaloviral inclusions after Ganciclovir treatment.
Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.
Hruban
Z
Z
Department of Pathology, University of Chicago, Illinois.
Kuzo
R
R
Heimann
P
P
Weisenberg
E
E
Hruban
R H
RH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D016026:Bone Marrow Transplantation; D002213:Capsid / Q000648:ultrastructure; D003587:Cytomegalovirus / Q000187:drug effects* / Q000648:ultrastructure; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004279:DNA, Viral / Q000096:biosynthesis / Q000187:drug effects; D004801:Eosine Yellowish-(YS); D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation; D008168:Lung / Q000382:microbiology / Q000648:ultrastructure*; D008297:Male; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology
D004279:DNA, Viral; D015774:Ganciclovir; D004801:Eosine Yellowish-(YS)