Expression of basic fibroblast growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma.
In our previous work we demonstrated that prostate-derived growth factor (PrGF) is homologous to basic fibroblast growth factor (bFGF), not acidic fibroblast growth factor (aFGF). Using Northern blot analysis we now show that the messenger RNA for bFGF but not aFGF is expressed in benign prostatic hyperplastic (BPH) tissue as well as in carcinoma of the prostate (CAP). This not only corroborates our previous results, but suggests that PrGF is produced locally and not merely stored in the prostate. The demonstration of local production of bFGF by prostate tissue may indicate that this growth factor plays a role, either alone or in conjunction with other factors, in the etiology of benign hyperplasia or prostatic cancer.
Mydlo
J H
JH
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Michaeli
J
J
Heston
W D
WD
Fair
W R
WR
D000818:Animals; D015152:Blotting, Northern; D002277:Carcinoma / Q000032:analysis* / Q000473:pathology; D015342:DNA Probes; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D011467:Prostate / Q000032:analysis / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats
D015342:DNA Probes; D012333:RNA, Messenger; D005346:Fibroblast Growth Factors