title: Tritium toxicity in postnatally developing brain: effects of single administration on nucleic acids and protein.
abstract: The brains of postnatally developing mice were studied at one, two, three, four, five and six weeks of age after injecting one day old neonates (1.95 +/- 0.35 g) with 11.1 kBq and 111 kBq/ml of body water. The HTO-exposed developing animals though do not show any significant decline in their brain and body weight, their DNA concentration was found significantly depleted at one week by 19% after the treatment with 111 kBq dose and subsequently recovered by six week reaching 93% of the control. Protein concentration showed significant deficit in both the dose groups at all the postnatal intervals. Protein/DNA ratio increased in one and two weeks old mice and reduced from four weeks onward. RNA/DNA ratio has also been found consistently low in irradiated groups.
authors: Radiation Biology Laboratory, University of Rajasthan, Jaipur, India.
authors: A L
authors: AL
authors: Bhatia
authors: A
authors: A
authors: Saraswat
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000528:radiation effects*; D004247:DNA / Q000008:administration & dosage; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D012313:RNA / Q000008:administration & dosage; D011833:Radiation Injuries, Experimental; D014316:Tritium / Q000009:adverse effects*
chemical_list: D014316:Tritium; D012313:RNA; D004247:DNA