The protective action of a water poor in calcium on the kidney of guinea-pigs treated with 9-alpha-fluoro-16-beta-methylprednisolone.
A series of experiments was conducted on guinea-pigs treated with 9-alpha-fluoro-16-beta-methylprednisolone in order to evaluate the histomorphological damage to the renal parenchyma. Animals that were subjected at the same time to hydropinic therapy based on a mineral water with a very low saline content (oligomineral waters) exhibited far less damage than the control group which received aqua fontis.
Agostini
G
G
Institute of Clinical Dermatology, University of Pisa, Italy.
Martini
P
P
Mian
M
M
Renzoni
G
G
D000818:Animals; D001623:Betamethasone / Q000633:toxicity*; D002118:Calcium / Q000032:analysis*; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D007679:Kidney Medulla / Q000187:drug effects / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D008900:Mineral Waters / Q000032:analysis*; D013194:Staining and Labeling
D008900:Mineral Waters; D001623:Betamethasone; D002118:Calcium