Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites.
The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune response to this pathogen. In this report, we have analyzed an immunodominant site on the hemagglutinin (residues 202-221) recognized by murine class I MHC-restricted T lymphocytes. This analysis has revealed evidence for the duplication of a T cell recognition site within the region 202-221. We have also identified critical amino acids necessary for class I-restricted T cell recognition within these two epitopes. In addition, we provide evidence that a site on the influenza hemagglutinin recognized by neutralizing antibody directly overlaps with an epitope recognized by class I MHC-restricted CTL.
Sweetser
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MT
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
Braciale
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Braciale
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TJ
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes; D006183:H-2 Antigens / Q000276:immunology*; D015707:HN Protein / Q000276:immunology; D006389:Hemagglutinins, Viral / Q000276:immunology*; D009980:Influenza A virus / Q000145:classification / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000276:immunology; D013329:Structure-Activity Relationship; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D006183:H-2 Antigens; D015707:HN Protein; D006389:Hemagglutinins, Viral; D009842:Oligopeptides