title: Histamine directly gates a chloride channel in lobster olfactory receptor neurons.
abstract: Biogenic amines mediate many types of intercellular communication in multicellular organisms. Heretofore, little direct evidence has indicated that biogenic amines produce intracellular responses other than by triggering the enzymatic production of second messengers. Our electrophysiological studies of lobster olfactory receptor neurons now reveal that one biogenic amine, histamine, can directly gate an ion channel. The channel responds to histamine concentrations of 1 microM or more, is permeable primarily to Cl-, is more active at depolarized potentials, and has a conductance of 44 pS in the American lobster and 66 pS in the Caribbean spiny lobster. The expression of this ligand-gated channel in olfactory receptor neurons implies that these neurons are targets of a regulatory or feedback process.
authors: Whitney Laboratory, University of Florida, Saint Augustine 32086.
authors: T S
authors: TS
authors: McClintock
authors: B W
authors: BW
authors: Ache
mesh_terms: D000818:Animals; D018118:Chloride Channels; D002712:Chlorides; D004553:Electric Conductivity; D005071:Evoked Potentials / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D008121:Nephropidae; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011738:Pyrilamine / Q000494:pharmacology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D012903:Smell
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D007473:Ion Channels; D008565:Membrane Proteins; D006632:Histamine; D011738:Pyrilamine