Monoamines, glucose metabolism, aggression towards self and others.
The evidence is reviewed that violent and suicidal behavior is associated with a deficiency of the serotonin system and that individuals with poor impulse control tend to become hypoglycemic during an oral glucose tolerance test, and have low levels of 5-hydroxyindole acetic acid in the cerebrospinal fluid. It is postulated that serotonergic deficits may predispose individuals to poor impulse control, disturbance of glucose metabolism, alcohol abuse, violent behavior and suicide.
Roy
A
A
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Virkkunen
M
M
Linnoila
M
M
D000374:Aggression / Q000502:physiology*; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid*; D003617:Dangerous Behavior / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007003:Hypoglycemia / Q000378:metabolism / Q000503:physiopathology*; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D013405:Suicide
D015306:Biogenic Monoamines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid