The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.
The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.
Croop
J M
JM
Department of Pediatric Hematology and Oncology, Childrens Hospital, Boston, Massachusetts.
Raymond
M
M
Haber
D
D
Devault
A
A
Arceci
R J
RJ
Gros
P
P
Housman
D E
DE
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D004351:Drug Resistance / Q000235:genetics*; D005786:Gene Expression Regulation; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D005810:Multigene Family; D012313:RNA / Q000235:genetics / Q000378:metabolism; D014018:Tissue Distribution; D014158:Transcription, Genetic
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins; D012313:RNA