Endothelin-1 participation in overt and inflammatory pain.
Endothelin-1 (ET-1) induced hyperalgesia in rats, abdominal constrictions in mice, incapacitation in dogs, and, when injected intradermally into humans, caused wheal and flare responses, which were accompanied by itching. The ET-1 induced constrictions in mice were prevented by indomethacin. In contrast, indomethacin had no effect on the hyperalgesic responses in the rat. These results indicate that ET-1 may play a role in modulating pain.
Ferreira
S H
SH
Department of Pharmacology, Faculty of Medicine of Riberao Preto USP, Brazil.
Romitelli
M
M
de Nucci
G
G
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D016232:Endothelins; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced* / Q000150:complications; D007271:Injections, Intradermal; D051379:Mice; D010146:Pain / Q000139:chemically induced*; D010147:Pain Measurement; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D016232:Endothelins; D010455:Peptides; D007213:Indomethacin