Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin.
The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.
Di Marzo
V
V
Department of Biochemistry, Imperial College of Science and Technology, London.
Tippins
J R
JR
Galadari
S H
SH
Morris
H R
HR
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology; D019004:Galanin; D066298:In Vitro Techniques; D036341:Intercellular Signaling Peptides and Proteins; D017999:Leukotriene E4; D008168:Lung / Q000378:metabolism; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000031:analogs & derivatives / Q000096:biosynthesis*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D036341:Intercellular Signaling Peptides and Proteins; D009478:Neuropeptide Y; D009479:Neuropeptides; D010446:Peptide Fragments; D010455:Peptides; D010972:Platelet Activating Factor; D011498:Protein Precursors; D013189:SRS-A; C053900:peptide histidine valine 42; D014660:Vasoactive Intestinal Peptide; D017999:Leukotriene E4; D019004:Galanin; C040442:heliodermin; D002116:Calcitonin