Beta 1 and beta 2 adrenergic agonists in exocrine pancreatic secretion in the rabbit.
The effect of Dobutamine (a beta 1-adrenergic agonist) and Terbutaline (a beta 2-adrenergic agonist) on exocrine pancreatic secretion was studied in anaesthetized rabbits, simultaneously controlling pancreatic blood flow and blood pressure. The secretion of fluid and ions (bicarbonate, sodium and potassium) was unaffected by the infusion of Dobutamine (8 micrograms.kg-1.min-1) or Terbutaline (10 micrograms.kg-1.min-1). Neither were pancreatic blood flow or mean blood pressure altered. Dobutamine or Terbutaline depress the function of the acinar cells, amylase secretion being more affected by the action of Terbutaline. The results show that beta 1 and beta 2-adrenergic stimulation has no effect on the ductular cells but does decrease the secretion by the acinar cells.
De Dios
I
I
Departamento de Fisiología y Farmacología, Facultad de Biología, Universidad de Salamanca, Spain.
Calvo
J J
JJ
San Roman
J I
JI
Plaza
M A
MA
Lopez
M A
MA
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004280:Dobutamine / Q000494:pharmacology; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D011506:Proteins; D004280:Dobutamine; D013726:Terbutaline