[Presence and distribution of cytokeratins and filaggrin in human anagen follicles].
The presence and distribution of several types of cytokeratins and of filaggrin in human anagen hair follicles were investigated using the following monoclonal antibodies (McAB): KL 1, CK 8.60, CK 8.12, PKK-2, CK 18, CK 19 and anti-filaggrin McAb. Constant and characteristic patterns of McAb labelling were obtained in distinct compartments of the hair follicle, except for CK 18, which failed to label any of the follicular cells. Anti-filaggrin McAb was regularly bound to the Henle's layer of the internal root sheath, showing for the first time the presence of "filament aggregating protein" in the human hair follicle.
Imcke
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E
Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz, Freien Universität Berlin.
Gollnick
H
H
Orfanos
C E
CE
D000911:Antibodies, Monoclonal; D000091344:Filaggrin Proteins; D006197:Hair / Q000033:anatomy & histology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D012627:Sebaceous Glands / Q000033:anatomy & histology
D000911:Antibodies, Monoclonal; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007633:Keratins
Vorkommen und Verteilung von Zytokeratinen und Filaggrin in humanen Anagenfollikeln.