Pagetoid dyskeratosis: a selective keratinocytic response.
Pale cells that resemble those of Paget's disease have been found within apparently normal epidermis in a variety of benign papules. Although they have been considered an artifact, they show characteristic premature keratinization. In contrast to other dyskeratotic processes they mature into orthokeratotic squamae. The histopathologic, ultrastructural and immunocytochemical features of these cells are illustrated, and the differential diagnosis is reviewed.
Tschen
J A
JA
Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
McGavran
M H
MH
Kettler
A H
AH
D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D004817:Epidermis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D013194:Staining and Labeling / Q000379:methods
D007633:Keratins