Exocrine pancreatic response to isoproterenol in the rabbit under secretin and CCK stimulation.
The effect of isoproterenol (0.3 micrograms/Kg/min) on exocrine pancreatic secretion stimulated by secretin (1. C.U./Kg/h) and the octapeptide of cholecystokinin (OP-CCK 0.15 Ivy dog units/Kg/h) was studied in anaesthetized rabbits. Pancreatic blood flow remained unaffected by the action of isoproterenol; however, the administration of the beta-adrenergic agonist over an infusion of secretion an OP-CCK led to an increase in pancreatic juice flow (approximately 146% for secretin and 125% for OP-CCK) and HCO3-output (approximately 194% for secretin and 150% for OP-CCK), a potentiation being observed between the effects of secretin and isoproterenol. This kind of response, independent of vascular changes, is due to a direct action of isoproterenol on the ductular cells. Isoproterenol interferes with the action of secretin and OP-CCK in that it partially inhibits the stimulatory action of OP-CCK on the enzymatic secretion of the acinar cells in the rabbit pancreas and at the same time protein secretion decreases in the presence of secretin.
De Dios
I
I
Departamento de Fisiología y Farmacología, Facultad de Biología, Universidad de Salamanca, Spain.
Calvo
J J
JJ
San Román
J I
JI
Plaza
M A
MA
López
M A
MA
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000681:Amylases / Q000097:blood; D000818:Animals; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D010186:Pancreatic Function Tests / Q000379:methods*; D010189:Pancreatic Juice / Q000187:drug effects; D011817:Rabbits; D012633:Secretin; D012636:Secretory Rate / Q000187:drug effects; D012844:Sincalide; D014882:Water-Electrolyte Balance / Q000187:drug effects
D012633:Secretin; D000681:Amylases; D007545:Isoproterenol; D012844:Sincalide