[A case of Henoch-Schoenlein purpura with extremely low OKT4 positive T lymphocytes].
We present a patient with Henoch-Schoenlein purpura who had extremely low number of OKT4 positive T lymphocytes. However his lymphocytes responded normally to Leu3a and Coulter T4, which are also monoclonal antibodies that react with CD4 epitope. In vitro lymphocyte function tests revealed that helper-inducer T cell functions were normal. From these findings, we concluded that this patient had an abnormality in the epitope of CD4 positive cells. Since expression of OKT4 antigens in his mother was also low, we considered the possibility of hereditary factors although no relationship with HLA was found.
Hirano
C
C
Aida
H
H
Asami
A
A
Suzuki
S
S
Bamba
M
M
Hirose
M
M
Kanayama
M
M
Yamanaka
M
M
D000911:Antibodies, Monoclonal / Q000032:analysis; D015704:CD4 Antigens / Q000276:immunology*; D002675:Child, Preschool; D000939:Epitopes / Q000276:immunology; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D000939:Epitopes