Statistical pitfalls in the analysis of age-related effects in antihypertensive therapy.
Much of the literature concerning age-related effects in antihypertensive therapy suffers from serious deficiencies in statistical design and analysis. The problems include those relating to the choice of a suitable control group, the measurement of response to treatment, response to baseline blood pressure, interpreting post hoc analyses, and the pooling of data from a number of related studies. These problems are discussed and we attempt to identify solutions that give a satisfactory balance between scientific validity and the real-life problems of conducting clinical trials. We conclude by outlining a protocol for future studies in this area.
Murray
G D
GD
University Department of Surgery, Western Infirmary, University of Glasgow, Scotland.
Lesaffre
E
E
D000368:Aged; D000375:Aging / Q000502:physiology*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D013223:Statistics as Topic
D000959:Antihypertensive Agents