title: Tumor necrosis factor induces acute phase proteins in rats.
abstract: Inoculation of WAG rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum (haptoglobin, alpha 1 acid glycoprotein, alpha 2 macroglobulin) and in the plasma (fibrinogen). We conclude that TNF may play an important role in the inflammatory response in vivo and possibly in the pathogenesis of inflammatory disorders.
authors: Lab. Viral Oncology, CNRS, Villejuif, France.
authors: I
authors: I
authors: Gresser
authors: F
authors: F
authors: Delers
authors: N
authors: N
authors: Tran Quangs
authors: S
authors: S
authors: Marion
authors: R
authors: R
authors: Engler
authors: C
authors: C
authors: Maury
authors: C
authors: C
authors: Soria
authors: J
authors: J
authors: Soria
authors: W
authors: W
authors: Fiers
authors: J
authors: J
authors: Tavernier
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis* / Q000187:drug effects; D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D000209:Acute-Phase Proteins; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma