[Cholesterol-containing circulating immune complexes--a component of the blood serum in patients with ischemic heart disease that determines its atherogenic properties].
In most patients with coronary heart disease (CHD) and angiographically documented stenosed 1-3 coronary arteries, serum contained cholesterol (C) in the circulating immune complexes (CIC), cholesterol levels in these complexes being directly related to serum atherogenicity, i.e. to their ability to cause a 2-5-fold accumulation of lipids in cultured smooth muscle cells (SMC) of the uninvolved human aortic intima (r = 0.91). Removal of IgG and IgM from the patients' sera led to a 75 and 37% decrease, respectively, in their atherogenic properties displayed in cultured SMC. Much more decrease in the atherogenic potential of the sera was seen in 2.5% polyethylene glycol-induced precipitation of CIC. At the same time, incubation of human aortic intimal SMC with CIC isolated from the atherogenic sera from CHD patients caused a 1.5-3-fold increase in intracellular C levels. It was suggested that CIC cholesterol was a determinant of atherogenicity of the sera from patients with coronary atherosclerosis.
Tertov
V V
VV
Kacharava
A G
AG
Saiadian
Kh S
KhS
Serebrennikov
S G
SG
Liakishev
A A
AA
Kozlov
S G
SG
Gratsianskiĭ
N A
NA
Rogova
E M
EM
Bocharova
O I
OI
Orekhov
A N
AN
D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology*; D002478:Cells, Cultured; D002784:Cholesterol / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000209:etiology* / Q000378:metabolism; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D000939:Epitopes; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000378:metabolism; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology
D000936:Antigen-Antibody Complex; D000939:Epitopes; D002784:Cholesterol
Kholesterinsoderzhashchie tsirkuliruiushchie immunnye kompleksy-- komponent syvorotki krovi bo'lnykh ishemicheskoĭ bolez'niu serdtsa obuslovlivaiushchiĭ ee aterogennos't.