title: Nucleolar organizer regions of lymphomas in Korea.
abstract: Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells and which possess ribosomal RNA (rRNA) genes. The numbers and/or configurations of NORs have been thought to be related to cellular activities. To assess the applicability of NORs associated protein (Ag-NORs) in the field of diagnostic histopathology, a silver staining was done in paraffin sections of malignant lymphomas, tonsils and reactive lymph nodes and the numbers of Ag-NORs in the nuclei of low-grade and those of high-grade lymphomas were compared. A significant difference was found between the numbers of Ag-NORs in the nuclei of low-grade lymphoma (a mean of 1.3 per nucleus) and those of high-grade lymphomas (a mean of 4.2 to 8.3 per nucleus). The Ag-NORs were often observed in nuclei in areas where nucleoli themselves were not visible in H&E stain. It is suggested that this method would be of great value in the field of tumor histopathology.
authors: Department of Pathology, Korea University Hospital.
authors: I
authors: I
authors: Kim
authors: S H
authors: SH
authors: Park
authors: S Y
authors: SY
authors: Paik
mesh_terms: D006652:Histological Techniques; D006801:Humans; D007723:Korea; D008228:Lymphoma, Non-Hodgkin / Q000208:ethnology / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012834:Silver; D013194:Staining and Labeling
chemical_list: D012834:Silver