The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.
Several glycoproteins that control blood-cell production and function have been purified and sequenced. The four colony-stimulating factors interact in a complex way to regulate the differentiation and maturation of the granulocyte and macrophage lineages and have potential applications for the clinical manipulation of blood-cell production.
Metcalf
D
D
Cancer Research Unit, Walter and Eliza Hall Institute, Royal Melbourne Hospital, Victoria, Australia.
D002454:Cell Differentiation; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000502:physiology; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes / Q000166:cytology; D006133:Growth Substances / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007938:Leukemia / Q000473:pathology; D008264:Macrophages / Q000166:cytology
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor