The effect of smoking on caffeine elimination: implications for its use as a semiquantitative test of liver function.
1. The effects of caffeine ingestion and cigarette smoking on caffeine and antipyrine pharmacokinetics were studied using normal subjects as their own controls before and after cessation of smoking in an attempt to minimize genetic and other environmental influences. 2. Moderate caffeine ingestion had no inducing effect on caffeine or antipyrine clearance. 3. Cessation of cigarette smoking significantly reduced clearance of caffeine and antipyrine. 4. These results demonstrate that cigarette smoking significantly affects caffeine pharmacokinetics and this may contribute to the variable results for caffeine kinetics found in patients with liver disease.
Murphy
T L
TL
Department of Biochemistry, University of Queensland, Royal Brisbane Hospital, Australia.
McIvor
C
C
Yap
A
A
Cooksley
W G
WG
Halliday
J W
JW
Powell
L W
LW
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D002110:Caffeine / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D002110:Caffeine; D000983:Antipyrine; D015056:1-Methyl-3-isobutylxanthine