title: The pathogenesis of spinal epidural abscess: microangiographic studies in an experimental model.
abstract: An experimental model of spinal epidural abscess was developed in rabbits by injecting Staphylococcus aureus into the posterior thoracolumbar epidural space. This model has been shown to reproduce the neurological, bacteriological, and radiological aspects of the human disease. In this study, the effect of the infectious epidural mass on the vasculature of the spinal cord in paraplegic rabbits was studied using microangiographic techniques. The normal vascular anatomy of the rabbit spinal cord was defined in control experiments. Vascular proliferation was demonstrated in the epidural space surrounding the abscesses. Anterior and paired posterior spinal arteries remained patent in paraplegic rabbits with mild or moderate spinal cord compression and in some cases of severe compression. In animals with severe compression, the anterior epidural venous plexus remained patent, but the dorsal spinal vein was occluded. Occlusion of perforating arteries occurred only with extreme spinal cord compression. These data indicate that the initial neurological deficit associated with experimental spinal epidural abscess is not due to vascular thrombosis.
authors: Department of Surgery (Section of Neurosurgery), University of Michigan Medical Center, Ann Arbor.
authors: J A
authors: JA
authors: Feldenzer
authors: P E
authors: PE
authors: McKeever
authors: D R
authors: DR
authors: Schaberg
authors: J A
authors: JA
authors: Campbell
authors: J T
authors: JT
authors: Hoff
mesh_terms: D000038:Abscess / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D000792:Angiography; D000818:Animals; D004824:Epidural Space; D007796:Laminectomy; D009389:Neovascularization, Pathologic / Q000209:etiology; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000209:etiology; D010264:Paraplegia / Q000209:etiology; D013116:Spinal Cord / Q000098:blood supply*; D013117:Spinal Cord Compression / Q000209:etiology; D013122:Spinal Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology