title: Effects of nicardipine on blood pressure and platelet cytosolic free calcium concentration in SHR.
abstract: Intracellular free calcium concentration was measured by the fluorescent calcium indicator quin2 method in platelets of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, and the effects of nicardipine on platelet cytosolic free calcium concentration were investigated. Cytosolic free calcium concentration was significantly increased in platelets of 4-, 11-, and 14-week-old SHR compared with age-matched WKY rats. Platelet cytosolic free calcium concentration in 14-week-old male SHR was significantly decreased 1 h after the administration of nicardipine (5 mg/kg p.o.), while that in WKY rats remained unchanged. These results suggest that transmembrane Ca2+ influx is genetically increased in SHR.
authors: Department of Medicine, Wakayama Medical College, Japan.
authors: A
authors: A
authors: Baba
authors: K
authors: K
authors: Fukuda
authors: M
authors: M
authors: Kuchii
authors: T
authors: T
authors: Hano
authors: I
authors: I
authors: Nishio
authors: Y
authors: Y
authors: Masuyama
mesh_terms: D000284:Administration, Oral; D000634:Aminoquinolines; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D005456:Fluorescent Dyes; D008297:Male; D009529:Nicardipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D000634:Aminoquinolines; D005456:Fluorescent Dyes; C035738:Quin2-acetoxymethyl ester; D009529:Nicardipine; D002118:Calcium