Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.
The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrease of wakefulness (W) and light slow wave sleep (SWS1). High doses (0.63-2.5 mg/kg) produced opposite effects. Paradoxical sleep (PS) was significantly reduced over the dose range tested. The increase of SWS2 after low doses of risperidone could be related to a predominant and potent 5-HT2 receptor blocking activity.
Dugovic
C
C
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Wauquier
A
A
Janssen
P A
PA
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin / Q000187:drug effects; D018967:Risperidone; D012890:Sleep / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects*
D014150:Antipsychotic Agents; D007555:Isoxazoles; D010080:Oxazoles; D010880:Piperidines; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D018967:Risperidone