Core histone acetylation during lymphocyte activation.
Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.
Profumo
A
A
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Querzola
F
F
Vidali
G
G
D000107:Acetylation; D003720:Densitometry; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D012313:RNA / Q000096:biosynthesis
D006657:Histones; D012313:RNA