Kidney- and serum derived proteins in urine of patients suffering from renal diseases or arterial hypertension.
Excretion patterns of kidney related urinary proteins such as lysosomal beta-N-acetylglucosaminidase (beta NAG), brush-border Ala-(Leu-Gly)-aminopeptidase (AAP), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (AP) as well as of IgG, albumin, and alpha-1-microglobulin, were assessed in patients with chronic glomerulonephritis (n = 53), pyelonephritis (n = 27), systemic lupus erythematodes (n = 5), and patients with essential arterial hypertension (n = 18). Excretion of tubular marker enzymes and serumproteins (related to urine creatinine concentration = protein creatinine index) in spontaneously voided second morning urine was significantly higher as compared to the controls (n = 2). Alpha-1-microglobulin was markedly elevated in both pyelonephritis and glomerulonephritis indicating disturbance in tubulointerstitial handling of microglobulins also in cases with primary glomerulopathy. Rise of albumin, IgG, and alpha-1-microglobulin as well as of tubular kidney markers AAP, AP, GGT, and beta NAG in cases with arterial hypertension without preexisting nephropathy support the hypothesis of a defect in charge and size permselectivity in these patients which is probably due to an increase in glomerular capillary perfusion pressure and hyperfiltration.
Scherberich
J E
JE
Abteilung Nephrologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main.
Mösbauer
A
A
Meissner
A
A
Bentele
D
D
Schoeppe
B
B
Schoeppe
W
W
D000328:Adult; D000368:Aged; D000419:Albuminuria; D000510:Alpha-Globulins / Q000652:urine; D001798:Blood Proteins / Q000032:analysis*; D003404:Creatinine / Q000652:urine; D004798:Enzymes / Q000652:urine; D005260:Female; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007074:Immunoglobulin G / Q000652:urine; D007674:Kidney Diseases / Q000150:complications*; D007677:Kidney Function Tests; D008181:Lupus Nephritis / Q000150:complications; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000175:diagnosis* / Q000201:enzymology; D011704:Pyelonephritis / Q000150:complications
D000510:Alpha-Globulins; D001798:Blood Proteins; D004798:Enzymes; D007074:Immunoglobulin G; C016001:alpha-1-microglobulin; D003404:Creatinine