Influence of the PG-analogues iloprost, nalador and nileprost on rejection time and TXB2 content of murine tail skin allografts.
Iloprost (2 X 330 micrograms/kg sc./d) better than nalador (2 X 500 micrograms/kg sc./d) prolonged the average time until the complete rejection of murine tail skin allografts in inbred mice. Nileprost (2 X 500 micrograms/kg sc./d) showed a similar trend. The TXB2 content in the ambient skin at the transplantation site was significantly diminished by all three PG-analogues, but by nileprost more than by iloprost or nalador.
Becker
K
K
Department of Pharmacology and Toxicology, Martin Luther University, Helle-Wittenberg, GDR.
Lueddeckens
G
G
von Baehr
R
R
Förster
W
W
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D015232:Dinoprostone / Q000031:analogs & derivatives*; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D016285:Iloprost; D051379:Mice; D008810:Mice, Inbred C57BL; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D012016:Reference Values; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D016038:Skin Transplantation; D013929:Thromboxane B2 / Q000378:metabolism*; D014184:Transplantation, Homologous
D002317:Cardiovascular Agents; D011459:Prostaglandins E, Synthetic; C016767:sulprostone; D013929:Thromboxane B2; D011464:Epoprostenol; D016285:Iloprost; D015232:Dinoprostone; C038832:nileprost