Chromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1.
Afr-1 is a gene whose product contributes to the adult regulation of mouse alpha-fetoprotein (AFP). In Afr-1b/b homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1a/a or Afr-1a/b mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1a or Afr-1b, respectively) to pristane-induced plasmacytomas.
Blankenhorn
E P
EP
Department of Microbiology and Immunology, Hahnemann University, Philadelphia, Pennsylvania 19102-1192.
Duncan
R
R
Huppi
K
K
Potter
M
M
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011995:Recombination, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics*
D000509:alpha-Fetoproteins