Simultaneous production of the alpha-subunit of glycoprotein hormones and other hormones in pituitary adenomas.
The immunohistological classification of 97 pituitary adenomas revealed in 34 cases alpha-subunit (a-su) positive cells in the tumor tissue. In 15 cases a-su was the only hormone found, in 11 cases the beta-subunits of the glycoprotein hormones could also be detected (10 cases with LH/FSH and 1 case with TSH). In 8 cases a-su was found simultaneously together with other hormones of the pituitary (ACTH and a-su in 1 case, GH and a-su in 4 cases, prolactin and a-su in 2 cases, prolactin, GH and a-su in 1 case). A-su could be demonstrated to be partly simultaneously produced together with these hormones in identical cells and secretory granules. Next to prolactin, the a-su was the second most frequently occurring hormone that could be detected immunohistologically in our material.
Jautzke
G
G
Universitätsklinikum R. Virchow, Institut für Pathologie, Berlin West, West Germany.
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D015292:Glycoprotein Hormones, alpha Subunit / Q000032:analysis*; D006801:Humans; D007106:Immune Sera; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010908:Pituitary Hormones, Anterior / Q000032:analysis*; D010911:Pituitary Neoplasms / Q000473:pathology*
D015292:Glycoprotein Hormones, alpha Subunit; D007106:Immune Sera; D010908:Pituitary Hormones, Anterior