title: A device for the production of fresh tumor slices for cytotoxic drug testing.
abstract: The potential suitability of thin slices of fresh tumor tissue for the in vitro testing of antitumor drugs was studied. With a simple device, sets of tumor slices of equal thickness were produced rapidly with minimal cellular damage. The sections showed a reproducible stable incorporation of 3H-thymidine for incubation periods of more than 24 h. Preliminary data on the effect of cytotoxic drugs on sections of xenografts of human squamous cell carcinoma revealed a distinct correlation between their in vitro effects on 3H-thymidine incorporation and their in vivo sensitivity in nude mice.
authors: Department of Otorhinolaryngology, University Hospital, Nijmegen, The Netherlands.
authors: D
authors: D
authors: Elprana
authors: J
authors: J
authors: Schwachöfer
authors: W
authors: W
authors: Kuijpers
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans; D051379:Mice; D008867:Microtomy / Q000295:instrumentation*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*
chemical_list: D001761:Bleomycin; D002945:Cisplatin