Pharmacokinetics of plasmatic plasminogen activator in rabbits.
The pharmacokinetic characteristics of APP were studied in 10 male New Zealand rabbits. An initial dose of 15,000 IU of APP per kg of weight was administered. The respective fibrinolytic activity was estimated by fibrin plates and transformed according to theoretical considerations. Knorre's criterion was used for the determination of the number of compartments. In every case the values were below 0.2 which indicates a one-compartment open model. The data were fitted to the proposed model in two steps; first the stripping method was used, afterwards the values obtained by the stripping were used as initial values for nonlinear fitting by means of nonlin programs.
González Rey
J R
JR
National Institute of Angiology and Vascular Surgery, Department of Pharmacological Research, Havana, Cuba.
Cuevas Valdespino
M
M
Cardona
M
M
Díaz
A
A
Gongora
C
C
Pérez
B
B
Sánchez
J
J
D000042:Absorption; D000818:Animals; D004334:Drug Administration Schedule; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
D010960:Plasminogen Activators