Apheretic treatment of severe familial hypercholesterolemia: comparison of dextran sulfate cellulose and double membrane filtration methods for low density lipoprotein removal.
The two more widely available techniques for the extracorporeal removal of low density lipoproteins (LDL), dextran sulfate cellulose column and double membrane filtration, were comparatively tested in severe familial hypercholesterolemic patients, both acutely and during a continued 3-month treatment. The selective dextran sulfate procedure removed close to 60% of LDL and 16% of high density lipoproteins (HDL) upon each apheresis, vs. 42% and 32%, respectively, in the case of the semi-selective double membrane filtration. Upon long term biweekly treatments, LDL-cholesterol (LDL-C) decreased, with the selective procedure, from a pre-treatment level of 406.0 +/- 40.7 mg/dl to a value fluctuating between 295.4 +/- 33.8 mg/dl and 116.9 +/- 22.0 mg/dl (highest vs. lowest levels) whereas, in the case of double membrane filtration, LDL-C levels ranged between 334.8 +/- 39.8 mg/dl and 192.3 +/- 49.9 mg/dl. HDL-cholesterol levels were somewhat raised, to a higher extent with dextran sulfate apheresis. The LDL/HDL-cholesterol "atherogenic ratio", decreased from a pre-treatment value of 10.27 +/- 3.04 to values ranging between 3.61 and 6.82 with dextran sulfate and between 6.70 and 7.68 with double membrane plasmapheresis.
Franceschini
G
G
Center E. Grossi Paoletti, University of Milan, Italy.
Busnach
G
G
Vaccarino
V
V
Calabresi
L
L
Gianfranceschi
G
G
Sirtori
C R
CR
D000328:Adult; D002482:Cellulose; D002784:Cholesterol / Q000097:blood; D016264:Dextran Sulfate; D003911:Dextrans; D005260:Female; D005374:Filtration / Q000379:methods; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods*; D014280:Triglycerides / Q000097:blood
D003911:Dextrans; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002482:Cellulose; D016264:Dextran Sulfate; D002784:Cholesterol