title: Allogeneic bone marrow transplantation from HLA-identical siblings following conditioning with busulfan and cyclophosphamide. First results.
abstract: In the time period from November 1984 to January 1987 eight allogeneic bone marrow transplantation were performed from HLA-identical siblings. The theoretical chance of success in this group was between 21 and 50%, according to the recent data of the International Bone Marrow Transplant Registry, depending on the diagnosis and clinical condition. The average chance was 37.5%. Haemopoietic reconstitution was achieved in 6 recipients, while 2 died of early complications (cytostatic induced hepatocellular damage and fungal sepsis). Another 3 patients died of complications of the intermediate period (pulmonary bleeding, virus hepatitis, graft rejection). The remaining 3 recipients are alive, in excellent clinical condition, including one girl surviving more than 2 years after the transplantation.
authors: Haemopoietic Transplant Team, Central Clinical Hospital CSK WAM Warsaw, Poland.
authors: W
authors: W
authors: Wiktor-Jedrzejczak
authors: C
authors: C
authors: Szczylik
authors: H
authors: H
authors: Matej
authors: Z
authors: Z
authors: Pojda
authors: M Z
authors: MZ
authors: Ratajczak
authors: A
authors: A
authors: Myc
authors: M
authors: M
authors: Siekierzyński
authors: J
authors: J
authors: Kansy
authors: M
authors: M
authors: Kłos
authors: Z
authors: Z
authors: Rybicki
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000401:mortality / Q000601:surgery; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000601:surgery; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000601:surgery
chemical_list: D003520:Cyclophosphamide; D002066:Busulfan