Binding sites for endothelin-1 in rat tissues: an autoradiographic study.
By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.
Koseki
C
C
Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan.
Imai
M
M
Hirata
Y
Y
Yanagisawa
M
M
Masaki
T
T
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D016232:Endothelins; D007457:Iodine Radioisotopes; D008297:Male; D008861:Microsomes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin
D016232:Endothelins; D007457:Iodine Radioisotopes; D010455:Peptides; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin