Induction of angiogenic response by chemically stable prostacyclin analogs.
Angiogenic activities of several chemically stable prostacyclin analogs (isocarbacyclins and 7-fluoro prostacyclin) were evaluated by the chick embryo chorioallantoic membrane assay. These compounds showed potent angiogenic activity at very low concentration (0.1 micrograms/egg 1.0 micrograms/egg), whereas naturally occurring prostaglandins such as prostacyclin and PGE1 were almost ineffective up to 1 microgram/egg. Pretreatment of chorioallantoic membranes with dexamethasone or indomethacin inhibited the angiogenic response induced by these chemically stable prostacyclin analogs. These results indicate that these prostacyclin analogs induce the angiogenic response of chick chorioallantoic membranes via a mechanism involving activation of inflammatory cells, as well as through their direct angiogenic activity.
Ohtsu
A
A
Teijin Institute for Biomedical Research, Tokyo, Japan.
Fujii
K
K
Kurozumi
S
S
D000482:Allantois / Q000187:drug effects; D000818:Animals; D001681:Biological Assay; D002642:Chick Embryo; D002823:Chorion / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D009389:Neovascularization, Pathologic; D013329:Structure-Activity Relationship
D003907:Dexamethasone; D011464:Epoprostenol; D007213:Indomethacin