Methanol induced biogenic amine changes in discrete areas of rat brain: role of simultaneous ethanol administration.
Alteration in the steady state level of brain biogenic amines produced by methanol differ considerably in rats when compared to the effects produced by ethanol. When ethanol and methanol were administered simultaneously in identical concentration, the effects produced by methanol were much more pronounced in the presence of ethanol. This could be attributed to the delay in the metabolism of methanol as ethanol competes with methanol for alcohol dehydrogenase enzyme activity. Hence, it is presumed that the effects produced by methanol seem to be primarily due to the direct action of methanol itself and not due to metabolic end products of methanol. It is also inferred that if methanol per se is going to produce any permanent damage in the central nervous system due to abnormal neurotransmitter behaviour, they cannot be prevented by treatment with ethanol.
Jeganathan
P S
PS
Department of Physiology, PGIBMS, University of Madras.
Namasivayam
A
A
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D000432:Methanol / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D000432:Methanol