[Immunohistological differentiation of the cells of the arterial wall in transplanted kidneys].
22 nephrectomy specimens of renal allografts in chronic rejection after 3 months to 96 months were studied immunohistologically. The various cell types in the arterial wall were characterised with specific antibodies against different cells of the mononuclear phagocyte system, against smooth muscle cells, and for differentiating lymphatic cells. In addition, the metabolism of lipoproteins was studied using different antibodies against several apolipoproteins. According to our results, subendothelial plaques of foam cells consist of macrophages in foamy transformation. In the stage of intimal fibrosis, smooth muscle cells are more prominent. Lymphatic infiltration consists almost exclusively of T lymphocytes. Apolipoprotein analysis reveals deposits of Apolipoproteins A1 and B, mostly extracellular. On the whole, these results show that not only immunologic factors are involved in the reaction of the arterial wall in chronic transplant arteriopathy, but that like in atherosclerosis, disorders of lipoprotein metabolism, probably due to endothelial dysfunction, play an important role.
Roessner
A
A
Bögeholz
J
J
Bosse
A
A
Vollmer
E
E
Buchholz
E
E
Winde
G
G
Bründermann
H
H
D003893:Desmin / Q000378:metabolism; D006084:Graft Rejection; D006801:Humans; D007150:Immunohistochemistry; D016030:Kidney Transplantation / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D012077:Renal Artery / Q000473:pathology
D003893:Desmin
Immunhistologische Differenzierung der Zellen in der Arterienwand von Transplantatnieren.