Phase separation in bimolecular mixed lipid membranes induced by polylysine.
We demonstrate, for the first time, polylysine-induced phase separation in a bimolecular lipid membrane of a lecithin/phosphatidylglycerol-mixture by analysing the single channel current fluctuations of gramicidin. The bimodal conductance histograms are direct evidence for the incorporation of the transport system into the two coexisting phases of different composition.
Mittler-Neher
S
S
Max-Planck-Institut für Polymerforschung, Mainz, FRG.
Knoll
W
W
D004134:Dimyristoylphosphatidylcholine; D004553:Electric Conductivity; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes; D008563:Membrane Lipids / Q000378:metabolism*; D010715:Phosphatidylglycerols; D011107:Polylysine / Q000494:pharmacology*
D007473:Ion Channels; D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids; D010715:Phosphatidylglycerols; D011107:Polylysine; D004134:Dimyristoylphosphatidylcholine