title: Corticospinal projections from the medial wall of the hemisphere.
abstract: We injected wheat germ agglutinin conjugated to horseradish peroxidase into different segments of the spinal cord in order to examine the topographic organization of corticospinal projections from the medial wall of the hemisphere. We observed that substantial projections to the spinal cord originate not only from the supplementary motor area (SMA) in area 6, but also from 2 regions within the cingulate sulcus. The distribution of labeled neurons following tracer injections into different spinal cord segments indicates that corticospinal projections from the SMA and from the 2 cingulate regions are somatotopically organized. These findings together with other recent anatomical observations suggest that the corticospinal projections from the medial wall of the hemisphere provide the basal ganglia and limbic system with a somatotopically organized access to spinal cord mechanisms.
authors: Research Service, V. A. Medical Center, Syracuse, NY 13210.
authors: K D
authors: KD
authors: Hutchins
authors: A M
authors: AM
authors: Martino
authors: P L
authors: PL
authors: Strick
mesh_terms: D000818:Animals; D001931:Brain Mapping; D006179:Gyrus Cinguli / Q000033:anatomy & histology*; D006735:Horseradish Peroxidase; D008251:Macaca / Q000033:anatomy & histology*; D009044:Motor Cortex / Q000033:anatomy & histology*; D013116:Spinal Cord / Q000033:anatomy & histology*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase