[Pleomorphic adenoma of the salivary glands. Impact of the myxoid component on the prognosis].
In a series of 570 pleomorphic adenomas of main and accessory salivary glands, we found 48 recurrences (8.04%). These recurrences occurred between several months and 19 years after surgical treatment. They were more frequently noted in parotid tumors. Comparatively to a control series, in recurrent tumors myxoid structures were more frequent than epithelial structures, as demonstrated by immuno-markings (anti-protein S 100 and anti-vimentin sera). Besides, in these tumors, extracapsular myxoid expansions were commonly seen. The proliferative potential of myoepithelial cells which are the main cellular component of myxoid areas, is thus suggested as a mainly factor of recurrence of pleomorphic adenomas.
Goudot
P
P
Institut de Stomatologie et de Chirurgie Maxillo-faciale, Hôpital de la Pitié-Salpêtrière, Paris.
Auriol
M
M
Chomette
G
G
Vaillant
J M
JM
Guilbert
F
F
D008949:Adenoma, Pleomorphic / Q000032:analysis / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D009232:Myxoma / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000032:analysis / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins
Adénomes pléomorphes des glandes salivaires. Incidence de la composante myxoïde sur le pronostic.