title: Superior olivary and lateral lemniscal neurons projecting to the cochlea in the guinea pig.
abstract: Efferent neurons to the cochlea in the guinea pig were observed in the superior olivary complex and ventral lateral lemniscal nuclei after injection of WGA-HRP into the cochlea via the round window. Of HRP-labeled nerve cells found in the brainstem, about 60% and 10% were located in the ipsilateral lateral superior olivary nucleus (LSO) and the contralateral ventral nucleus of the trapezoid body (VTB), respectively. A few labeled neurons were found in the ipsilateral VTB, contralateral LSO and the bilateral superior paraolivary nucleus (SPO). Seven percent and 5% of the labeled neurons were definitely observed in the ventrocaudal part of the contra- and ipsilateral ventral nucleus of the lateral lemniscus (VLL), respectively. A combination of acetylcholine esterase (AChE) histochemistry with the tracing of retrograde axonal transport of a fluorescent dye (DAPI) revealed that VLL neurons projecting to the cochlea, as well as about 85% of LSO neurons projecting to the ipsilateral cochlea, were AChE-positive.
authors: Third Department of Anatomy, School of Medicine, Chiba University, Japan.
authors: A
authors: A
authors: Tokunaga
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001306:Auditory Pathways / Q000033:anatomy & histology* / Q000166:cytology; D002452:Cell Count; D003051:Cochlea / Q000294:innervation*; D004525:Efferent Pathways / Q000033:anatomy & histology / Q000166:cytology; D006168:Guinea Pigs; D006735:Horseradish Peroxidase; D009847:Olivary Nucleus / Q000033:anatomy & histology* / Q000166:cytology / Q000201:enzymology; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology* / Q000166:cytology / Q000201:enzymology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D000110:Acetylcholinesterase