Interferon production in patients infected with HIV-1.
The production of interferon (IFN) from cultured peripheral blood mononuclear cells (PBMC) after virus or mitogen stimulation was evaluated in 141 patients positive for antibodies to human immunodeficiency virus type 1 (HIV-1). IFN-alpha production by PBMC of patients at Centers for Disease Control (CDC) stage II (Walter Reed [WR] 1) was comparable to that produced by PBMC of healthy controls. However, cells of patients at early CDC stage III (WR 2) produced significantly lower titers of IFN-alpha (P less than .001), and IFN-alpha was almost absent at CDC stage IV (WR 6) (P less than .001). IFN-gamma production was altered in patients at late CDC stage III (WR 4-5) and CDC IV (WR 6). A strong correlation between the disappearance of antibodies to core proteins and low IFN-alpha level was observed. IFN-alpha levels were significantly diminished in patients positive for HIV antigen. Reduced IFN-alpha production paralleled the HIV-1-related depletion of CD4+ lymphocytes and might serve as an additional parameter in defining the stage of HIV-1 infection.
Rossol
S
S
I. Medizinische Klinik und Poliklinik, Universitätsklinik Mainz, FRG.
Voth
R
R
Laubenstein
H P
HP
Müller
W E
WE
Schröder
H C
HC
Meyer zum Büschenfelde
K H
KH
Hess
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D002478:Cells, Cultured; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D007372:Interferons / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009522:Newcastle disease virus / Q000276:immunology; D011379:Prognosis; D018139:Simplexvirus / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
D015483:HIV Antibodies; D015488:HIV Antigens; D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons