title: Regulation of pancreatic amylase by dietary carbohydrate in chronic alcoholic rats.
abstract: The nutritional adequacy of dietary ingredients is essential for optimal food consumption and growth of animals. Dietary carbohydrate levels regulate pancreatic amylase synthesis. Ethanol diets with 36% of total calories from ethanol and 11% from carbohydrate are nutritionally inadequate, whereas a 26% ethanol diet made isocaloric to the 36% alcohol diet by the addition of maltose-dextrins provides all nutrients in amounts recommended for normal growth. Young rats fed the modified ethanol diet for 3 months consume 101.4 ml of diet daily compared to 66.5 ml by those on the 36% ethanol diet. Increased food consumption results in (a) similar amounts of alcohol consumption (3.6 vs. 3.3 g/day), (b) a threefold enhancement in carbohydrate intake (5.1 vs. 1.7 g/day), and (c) a normal growth rate (6.7 vs. 3.1 g/day). Both the acinar content of amylase (20.2 +/- 0.3 micrograms/mg of protein) and the acinar response to cholecystokinin-octapeptide in 36% ethanol diet-fed rats are significantly reduced compared to those of 26% ethanol diet-fed rats (34.1 +/- 5.6 micrograms/mg of protein). These results confirm (a) the nutritional adequacy of the 26% ethanol diet compared to the 36% ethanol diet, and (b) that carbohydrate inadequacy, and not ethanol consumption per se, is the primary cause of pancreatic amylase insufficiency in chronic alcoholic rats.
authors: Alcohol Research Laboratory, VA Medical Center, Martinez, California 94553.
authors: H
authors: H
authors: Sankaran
authors: C Y
authors: CY
authors: Nishimura
authors: J C
authors: JC
authors: Lin
authors: E C
authors: EC
authors: Larkin
authors: G A
authors: GA
authors: Rao
mesh_terms: D000437:Alcoholism / Q000201:enzymology*; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004040:Dietary Carbohydrates; D000681:Amylases