Breed-specific dog-dandruff allergens.
Fifty-one patients with clinical history of dog allergy were skin prick tested with eight individual standardized dog breed-allergen preparations, one mixed breed-allergen preparation (Poodle/Alsatian), dog-serum albumin, and histamine hydrochloride, 1 mg/ml. All extracts were characterized by crossed immunoelectrophoresis and crossed radioimmunoelectrophoresis with a pool of sera from patients clinically sensitive to dog. The dog-breed extracts contained common antigens/allergens, as well as components represented only in one or two dog-breed extracts. The concentration corresponding 1000 BU/ml varied from 16 to 100 micrograms of protein per milliliter. The sensitivity of skin prick test was 67% to 88% for the various dog breed-allergen preparations, but only 18% for dog-serum albumin. Significant difference between the skin test response to different dog breed-allergen preparations indicating dog breed-specific allergens was obtained in 15% of the patients. There was no significant correlation between skin prick test results and symptoms related to a specific dog breed.
Lindgren
S
S
Department of Medicine I, Sahlgrenska Hospital, University of Göteborg, Sweden.
Belin
L
L
Dreborg
S
S
Einarsson
R
R
Påhlman
I
I
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000032:analysis / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000032:analysis; D004285:Dogs / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007123:Immunoelectrophoresis, Two-Dimensional / Q000379:methods; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012536:Scalp Dermatoses / Q000276:immunology*; D012882:Skin Tests; D013045:Species Specificity
D000485:Allergens; D000941:Antigens; D000939:Epitopes; D007073:Immunoglobulin E