Anaesthetic-related occurrence of early ventricular arrhythmias during acute myocardial ischaemia in rats.
The cardiovascular responses of rats anaesthetised with different anaesthetic agents to acute coronary artery ligation were studied. Before thoracotomy, urethane-anaesthetised animals exhibited significantly lower blood pressures. Ligation of the left coronary artery induced a high incidence of ventricular tachycardia or fibrillation in rats anaesthetised with pentobarbitone, urethane, or ether inhalation followed by chloralose. Ketamine-anaesthetised animals had a significantly lower incidence of ventricular arrhythmias. The mortality rate was also lower, though not statistically significant. However, all groups of rats showed essentially similar blood pressure and heart rate changes following coronary artery ligation as well as the time of onset of ventricular tachycardia or fibrillation. The findings demonstrate the influence of anaesthetics on the occurrence of early ventricular arrhythmias following acute coronary artery ligation in rats.
Dai
S
S
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
D000758:Anesthesia; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001794:Blood Pressure; D002698:Chloralose / Q000494:pharmacology; D003327:Coronary Disease / Q000150:complications*; D003331:Coronary Vessels; D004986:Ether / Q000494:pharmacology; D006339:Heart Rate; D008026:Ligation; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane / Q000494:pharmacology
D004986:Ether; D002698:Chloralose; D014520:Urethane; D010424:Pentobarbital