A randomized trial of the use of cocaine spray to provide pain relief during laser vaporization of the cervix.
In a double-blind trial, 50 patients undergoing laser vaporization of the cervix for cervical intraepithelial neoplasia were randomly allocated to one of two groups. One group had the cervix sprayed with 3-4 ml of a solution containing 10% cocaine, the other a placebo solution during the laser treatment. Women in the cocaine group had significantly less pain as assessed by a visual analogue scale (P less than 0.001) and by a verbal rating scale (P = 0.002). The cocaine group also had less blood loss (P = 0.001) as assessed subjectively by the operator.
Mikhail
M G
MG
St Mary's Hospital, Portsmouth.
Bevan
J R
JR
D000328:Adult; D000336:Aerosols; D002584:Cervix Uteri / Q000601:surgery*; D002986:Clinical Trials as Topic; D003042:Cocaine / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D053685:Laser Therapy; D010147:Pain Measurement; D010166:Palliative Care; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000601:surgery*
D000336:Aerosols; D003042:Cocaine