Effect of anti-allergic treatment on nasal surface basophilic metachromatic cells in allergic rhinitis.
The nasal surface basophilic metachromatic cells increase in allergic rhinitis and play an important role in the manifestation of nasal symptom. Their numbers were decreased in good correlation with the severity of symptom and nasal provocation reaction after clinical treatment with specific immunotherapy or topical steroid, beclomethasone dipropionate. The percentages of allergen induced histamine release from these cells were not changed after clinical treatment with cromolyn sodium.
Okuda
M
M
Dept. of Otolaryngology, Nippon Medical School, Tokyo, Japan.
Otsuka
H
H
Sakaguchi
K
K
Onishi
M
M
Okubo
K
K
D000281:Administration, Intranasal; D001491:Basophils / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use; D002452:Cell Count; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D009297:Nasal Mucosa / Q000166:cytology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000628:therapy
D001507:Beclomethasone; D004205:Cromolyn Sodium