title: Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia.
abstract: Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects other than a substantive reduction in platelet reactive antibodies, such as the alteration of IgG-coated platelet destruction.
authors: Department of Medicine, University of Alabama, Birmingham 35294.
authors: G
authors: G
authors: Barbano
authors: M N
authors: MN
authors: Saleh
authors: P G
authors: PG
authors: Mori
authors: A F
authors: AF
authors: LoBuglio
authors: D R
authors: DR
authors: Shaw
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000628:therapy*; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D005719:gamma-Globulins / Q000627:therapeutic use*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D005719:gamma-Globulins