[Fibrin glue and tricalcium phosphate implants in middle ear surgery. An animal experiment study].
Tricalcium phosphate (TCP) with and without heterologous fibrin glue has been used for obliteration of the mastoid cavity in middle ear surgery. The use of TCP with a homologous fibrin glue has not been described so far. Obliteration of 22 epitympanic and 51 femoral defects in rabbits by means of TCP-granulates without and with homologous fibrin glue was performed in 18 animals. Follow-up was for 2 weeks to 6 months. Histological osteo-integration was studied microscopically. Fibrin glue induces the development of soft tissue impeding osseous integration of the calcium phosphate for at least 6 weeks.
Reck
R
R
Universitäts-Hals-Nasen-Ohrenklinik Mainz.
Bernal-Sprekelsen
M
M
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000633:toxicity; D004338:Drug Combinations / Q000008:administration & dosage; D004432:Ear, Middle / Q000601:surgery*; D005176:Factor XIII / Q000008:administration & dosage*; D005269:Femur / Q000601:surgery; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D005549:Foreign-Body Reaction / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D019736:Prostheses and Implants; D011817:Rabbits; D013917:Thrombin / Q000008:administration & dosage*; D014945:Wound Healing
D002130:Calcium Phosphates; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; C020243:calcium phosphate; D013917:Thrombin; C485829:calcium phosphate, dibasic, anhydrous
Fibrinkleber und Tricalciumphosphat-Implantate in der Mittelohrchirurgie. Eine tierexperimentelle Studie.