Effects of localized, chronic GABA infusions into different cortical areas of the photosensitive baboon, Papio papio.
The effects of chronic (7 days) intracortical GABA infusions were investigated in both naturally photosensitive and non-photosensitive baboons. Bilateral and unilateral infusions into motor and occipital regions blocked photosensitivity, while premotor and prefrontal cortex infusions had no effect on the electro-clinical manifestations of this type of reflex epilepsy; the monkeys with prefrontal GABA infusions, however, showed selective attention deficits, detected with the delayed response test. In all cases a GABA withdrawal syndrome, appearing as epileptogenic spontaneous activity localized to the infused sites, was found at the cessation of GABA application. We conclude that GABAergic systems localized at discrete cortical areas play an important role in photosensitivity and in the modulation of cognitive processes in the monkey.
Brailowsky
S
S
Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Silva-Barrat
C
C
Ménini
C
C
Riche
D
D
Naquet
R
R
D000818:Animals; D001921:Brain; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D007263:Infusions, Parenteral; D009044:Motor Cortex / Q000187:drug effects / Q000503:physiopathology; D009778:Occipital Lobe / Q000187:drug effects / Q000503:physiopathology; D010215:Papio; D010775:Photic Stimulation; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid