[Characteristics of mucins and CEA in globoid dysplastic cells of human stomach and its relationship with signet ring cell carcinoma].
Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dysplastic cells and signet ring cells. The percentages of the three kinds of mucins seen in the two kinds of cells were not much different. It was indicated that the altered mucins in the gastric epithelial cells must be a sign of didifferentiation of the cells and the results of malfunction. The globoid dysplasia type I mainly contained neutral mucin whereas type II, the acid mucin was predominant, especially the sulphomucin. The CEA positive reaction became stronger as the atypia being remarkable, and the characteristics of distribution of CEA positive particles were similar in the two kinds of cells, namely, randomly or disorderly in the cells. Based on the analysis of the results, a conclusion can be made that the variety of mucins in globoid dysplastic cells can be used as a reference point in classification and is not much significant in grading, but the amount of CEA positive matter can be a reference point in grading. The globoid dysplasia is such a lesion with special features in morphology and function manifested in the process of didiferentiation towards signet ring cell carcinoma following the successive action of carcinogens upon the cells of gastric epithelium.
Liu
S Q
SQ
Cancer Institute, China University of Medical Sciences, Shenyang.
D002288:Adenocarcinoma, Mucinous / Q000276:immunology / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D009077:Mucins / Q000032:analysis*; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology*; D052116:Sialomucins; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D009077:Mucins; D052116:Sialomucins; C012564:sulfomucin