Influence of anaesthetics on the fibrinolytic activity in minipigs.
The activator of the fibrinolytic system measured in minipigs may be profoundly influenced by ether and halothane. Hexobarbital anaesthesia is recommended for studies where effects of fibrinolysis have to be measured. "Fibrinolytic shutdown" during anaesthesia may be prevented by prophylactic administration of a plasminogen activator releasing agent (pentosan polysulphate).
Klöcking
H P
HP
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
Sedlarik
K
K
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004986:Ether / Q000494:pharmacology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature
D000777:Anesthetics; D004986:Ether; D010426:Pentosan Sulfuric Polyester; D006591:Hexobarbital; D009609:Nitrous Oxide; D006221:Halothane