Influence of substance P on the bronchial reactivity of sensitized and nonsensitized guinea pigs in vivo.
Intravenous application of substance P (SP) (10 micrograms/kg) caused bronchoconstriction returning to baseline within 10 min. Pretreatment with SP did not influence the bronchoconstrictor response induced by allergen or carbachol.
Schreiber
J
J
Research Institute of Lung Diseases and Tuberculosis, Berlin-Buch, GDR.
Becher
G
G
Slapke
J
J
Nieber
K
K
Oehme
P
P
D000485:Allergens / Q000276:immunology; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D001982:Bronchial Diseases / Q000139:chemically induced* / Q000276:immunology; D002217:Carbachol; D003251:Constriction, Pathologic / Q000139:chemically induced; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D013373:Substance P / Q000494:pharmacology
D000485:Allergens; D013373:Substance P; D002217:Carbachol; D010047:Ovalbumin