title: Inhibition of Moloney murine leukemia virus reverse transcriptase by alpha-anomeric oligonucleotides.
abstract: After parallel hybridization to complementary template RNA, alpha-anomeric oligonucleotides are not primers for Moloney murine leukemia virus reverse transcriptase. As can be expected they are competitors of classical primer oligonucleotides (beta-anomeric). They therefore inhibit the RNA dependent DNA polymerase activity of Moloney murine leukemia virus reverse transcriptase with either homopolymeric or heteropolymeric substrates. Non complementary alpha-oligonucleotides display no inhibitory activity. alpha-Oligonucleotides are therefore potential candidates for inhibition of retroviral reverse transcriptases by interference with the primer binding sites.
authors: UA 147 CNRS, U 140 INSERM, Institut Gustave Roussy, Villejuif, France.
authors: M
authors: M
authors: Lavignon
authors: J R
authors: JR
authors: Bertrand
authors: B
authors: B
authors: Rayner
authors: J L
authors: JL
authors: Imbach
authors: C
authors: C
authors: Malvy
authors: C
authors: C
authors: Paoletti
mesh_terms: D001483:Base Sequence; D007536:Isomerism; D007700:Kinetics; D008979:Moloney murine leukemia virus / Q000201:enzymology*; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D013698:Templates, Genetic
chemical_list: D009838:Oligodeoxyribonucleotides; D018894:Reverse Transcriptase Inhibitors