Neurochemical basis for cocaine and methamphetamine interactions.
We have evaluated the responses of rat monoaminergic pathways to combinations of cocaine and methamphetamine (METH) administrations and found that these two commonly abused stimulants significantly interact. A 7-day pretreatment with daily doses of cocaine enhanced the neurochemical changes induced by multiple doses of METH in the dopaminergic and serotonergic systems of the basal ganglia and frontal cortex. When cocaine was administered concurrently, it attenuated or blocked the serotonergic changes caused by multiple doses of METH, but it did not interfere with the METH-mediated changes in the dopaminergic system.
Hanson
G
G
University of Utah, Salt Lake City.
Matsuda
L
L
Gibb
J
J
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000032:analysis; D004298:Dopamine / Q000032:analysis; D006719:Homovanillic Acid / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008694:Methamphetamine; D006897:Hydroxyindoleacetic Acid; D003042:Cocaine; D004298:Dopamine; D006719:Homovanillic Acid