The effect of galanin, CGRP and ANP on spontaneous smooth muscle activity of rat uterus.
In the present study the effect of the newly isolated peptides galanin, calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) was examined on spontaneous uterine smooth muscle activity on the rat in vitro. Galanin showed a slight and insignificant stimulatory effect on the amplitude, while both CGRP and ANP were found to be potent inhibitors of the uterine smooth muscle contractions. In connection with the recent demonstration of galanin and CGRP nerves in the genital tract, these pharmacological findings suggest that the peptides may participate in the control of nervous control of uterine muscular activity, although the exact physiological roles remain to be clarified.
Bek
T
T
Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark.
Ottesen
B
B
Fahrenkrug
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002116:Calcitonin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide; D004305:Dose-Response Relationship, Drug; D005260:Female; D019004:Galanin; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D009479:Neuropeptides; D010455:Peptides; D009320:Atrial Natriuretic Factor; D019004:Galanin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide