Activation of a Plasmodium falciparum protease correlated with merozoite maturation and erythrocyte invasion.
Protease-dependent processes of the P. falciparum schizogonic cycle are briefly described. The P. falciparum p76 protease is the first example of a biochemically regulated protease, the activation of which is related to merozoite maturation and/or erythrocyte invasion. The main known properties of the p76 protease are reviewed and some original results concerning its biosynthesis and biological properties are described.
Braun-Breton
C
C
Unité de Parasitologie Expérimentale, Institut Pasteur, Paris.
Pereira da Silva
L
L
D000818:Animals; D002458:Cell Fractionation; D004285:Dogs; D004789:Enzyme Activation; D004912:Erythrocytes / Q000469:parasitology*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000276:immunology; D008861:Microsomes / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects; D010447:Peptide Hydrolases / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000201:enzymology* / Q000254:growth & development; D011233:Precipitin Tests; D014176:Protein Biosynthesis; D012313:RNA / Q000302:isolation & purification
D008565:Membrane Proteins; D012313:RNA; D010447:Peptide Hydrolases