title: Subacute cutaneous lupus erythematosus lesions precipitated by griseofulvin.
abstract: Skin eruptions with features of subacute cutaneous lupus erythematosus occurred in a patient with dermatomyositis who was taking griseofulvin. The patient had antibodies against SSA/Ro and SSB/La antigens. Skin rashes disappeared after discontinuation of griseofulvin and recurred on challenge with the drug. These findings support previous studies that the photoactive drug may be synergistic with anti-SSA/Ro antibody to produce lesions of subacute cutaneous lupus erythematosus.
authors: Department of Dermatology, Nara Medical University, Japan.
authors: S
authors: S
authors: Miyagawa
authors: T
authors: T
authors: Okuchi
authors: Y
authors: Y
authors: Shiomi
authors: K
authors: K
authors: Sakamoto
mesh_terms: D000328:Adult; D001706:Biopsy; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006118:Griseofulvin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007633:Keratins; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000276:immunology; D012867:Skin / Q000473:pathology
chemical_list: D006118:Griseofulvin; D007633:Keratins