Effect of splenectomy upon the growth of B16-F10 melanoma and its relation to the interferon system.
The influence of splenectomy upon the growth of B16-F10 malignant melanoma and changes in interferon-synthesizing ability in mice were studied. Surgical stress alone temporarily diminished the ability of mice to respond to interferon induction by poly rIrC. Two weeks following the surgery, mock-splenectomized mice fully regained their interferon synthesis ability. However, this was not true in the case of splenectomized mice. They remained refractory to interferon induction. The removal of the spleen had no obvious effect on the rate of pulmonary metastasis in mice injected with B16-F10 malignant melanoma in relation to the mock-splenectomized or control mice. Mice that were splenectomized and inoculated with B16-F10 melanoma also remained refractory to interferon induction.
Stoll
H L
HL
Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, NY.
Chadha
K C
KC
D000818:Animals; D005260:Female; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D008175:Lung Neoplasms / Q000276:immunology / Q000601:surgery*; D008546:Melanoma, Experimental / Q000276:immunology / Q000601:surgery*; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D013154:Spleen / Q000276:immunology*; D013156:Splenectomy
D007369:Interferon Inducers; D007372:Interferons