Further characterization of sulfated homopolysaccharides as anti-HIV agents.
Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (AZT).
Sugawara
I
I
Department of Pathology, University of Tokyo, Japan.
Itoh
W
W
Kimura
S
S
Mori
S
S
Shimada
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D004357:Drug Synergism; D006678:HIV / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D011134:Polysaccharides / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D003911:Dextrans; D011134:Polysaccharides; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D016264:Dextran Sulfate; C007789:fucoidan