Inhibition of dopamine beta-hydroxylase by goitrin, a natural antithyroid compound.
RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.
Zenker
N
N
Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
Hubbard
L S
LS
Wright
J
J
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D051381:Rats; D011919:Rats, Inbred Strains
D013956:Antithyroid Agents; D010080:Oxazoles; D023303:Oxazolidinones; C004333:goitrin; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine