Calcium antagonists in ischemic stroke.
Clinical neurological examination, computed tomography (CT) scan, cerebral angiography, and cerebral blood flow-single photon emission computerized tomography (CBF-SPECT) study have been performed in 39 patients with acute ischemic stroke within 6 h from the onset of symptoms. Seven of these patients were submitted to a second CBF study after an intravenous infusion of nimodipine. A greater CBF impairment was observed in patients with severe neurological deficit at entry, poor outcome, cerebral arterial occlusion, and large hypodensity on the CT scan performed 1 week after admission. In patients treated with nimodipine, a significant increase of CBF was detected at the periphery of the ischemic zone, indicating a potential action of this Ca antagonist on the "ischemic penumbra."
Fieschi
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Department of Neurological Sciences, University of Rome La Sapienza, Italy.
Argentino
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C
Toni
D
D
Pozzilli
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C
D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000150:complications*; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000009:adverse effects / Q000627:therapeutic use; D011859:Radiography; D014055:Tomography, Emission-Computed
D002121:Calcium Channel Blockers; D009553:Nimodipine