[Biopharmaceutical aspects of a chemical approach to drug delivery: macromolecule-drug conjugates].
Some recent advances pertaining to the biopharmaceutical aspects of drug delivery are briefly given, followed by a review of the current status of the application of soluble macromolecular carriers for drug delivery. The dextran conjugates were selected as model compounds to demonstrate the implications of the biopharmaceutical approach in the design, evaluation, and delivery of macromolecular conjugates.
Sezaki
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D000818:Animals; D003911:Dextrans; D004337:Drug Carriers; D046911:Macromolecular Substances; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000493:pharmacokinetics; D011355:Prodrugs; D012995:Solubility
D003911:Dextrans; D004337:Drug Carriers; D046911:Macromolecular Substances; D008937:Mitomycins; D011355:Prodrugs; D016685:Mitomycin