title: Focal subdermal toxicity with subcutaneous opioid infusion in patients with cancer pain.
abstract: Few significant side effects have been reported from the treatment of cancer pain by subcutaneous infusion of opioids. In this prospective year-long study, 8 of 13 patients treated by this technique experienced painful chronic focal toxicity, manifested by induration, erythema and subdermal necrosis during subcutaneous analgesia therapy. A hydraulic-irritation effect is suggested.
authors: F
authors: F
authors: Adams
authors: L
authors: L
authors: Cruz
authors: M J
authors: MJ
authors: Deachman
authors: E
authors: E
authors: Zamora
mesh_terms: D000328:Adult; D000368:Aged; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000009:adverse effects*; D007263:Infusions, Parenteral / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects / Q000473:pathology*
chemical_list: D004091:Hydromorphone