[Specific brain antigens--an index of the permeability of the hemato-encephalic barrier in comatose states in children].
In 39 children with coma caused by infectious toxicosis, purulent meningoencephalitis and closed head trauma the brain-specific antigens (L1M and L2M globulins) contents were studied in the blood serum and cerebrospinal fluid (CSF). On days 3 to 5 after the head trauma L1M and L2M were found irregularly. In meningoencephalitis L1M and L2M were detected with a lesser delay. In infectious toxicosis L1M and L2M appeared in blood serum and CSF regularly and early. The data suggest that appearance of brain-specific antigens in blood and CSF in coma reflect a rise in the blood-brain barrier permeability to CSF-blood transport.
Lidzhieva
R Ts
RTs
Berestov
A I
AI
Chekhonin
V P
VP
Blokhin
B M
BM
Korobko
L M
LM
D000510:Alpha-Globulins / Q000032:analysis; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology*; D001930:Brain Injuries / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D002463:Cell Membrane Permeability; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007223:Infant; D008590:Meningoencephalitis / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D014777:Virus Diseases / Q000150:complications / Q000276:immunology / Q000503:physiopathology
D000510:Alpha-Globulins; D000939:Epitopes
Spetsificheskie antigeny mozga--pokazatel' pronitsaemosti gematoéntsefalicheskogo bar'era pri komatoznykh sostoianiiakh u deteĭ.