Acting out hostility in normal volunteers: negative correlation with levels of 5HIAA in cerebrospinal fluid.
We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
Roy
A
A
National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Adinoff
B
B
Linnoila
M
M
D000328:Adult; D000368:Aged; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006791:Hostility; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid
D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine; D006719:Homovanillic Acid