[Safety of long-term therapy with a combination of various anti-arrhythmia agents].
Safety and the effectiveness of combined therapy of arrhythmia was studied in 27 patients in prolonged (up to 4 months) administration of a combination of medicinal agents specially chosen during pharmacodynamic investigation. The obtained anti-arrhythmic effect was stable and there were no new side effects in prolonged administration of combinations of ethmozine with chinidin, ritmilen, obsidan, cordaron (amiodaron) and of allapinin with chinidin, ritmilen (disopyramide) and obsidan (propronalol). Tolerance to drugs was adequate and the ECG parameters remained unaffected.
Abdalla
A
A
Mazur
N A
NA
Sumarokov
A B
AB
Iavorskaia
N V
NV
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000633:toxicity; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors
D000889:Anti-Arrhythmia Agents
Bezopasnost' dlitel'noĭ terapii kombinatsieĭ razlichnykh antiaritmicheskikh preparatov.