title: Capsaicin-sensitive tachykinin-like immunoreactivity in the thymus of rats and guinea-pigs.
abstract: Capsaicin-sensitive, substance P-like immunoreactivity (SP-LI) has been detected recently in rat thymus. Other tachykinins are frequently present with SP. In the present study, tachykinin-like immunoreactivity (TK-LI) was measured in guinea-pig, rat, mouse and hamster thymus with the amount detectable being greatest in guinea-pig, less in rat and least in mouse; it was not detectable in hamsters. In guinea-pig and rat thymus, but not in mouse, TK-LI was markedly reduced by pretreatment with capsaicin. TK-LI levels correlated significantly with those of SP-LI in both guinea-pig and rat thymus. High-performance liquid chromatography (HPLC) fractions considered to represent neurokinin A, eledoisin and neuropeptide K were present in guinea-pig thymus but only the first two were present in rat thymus.
authors: Institute of Internal Medicine and Clinical Pharmacology, Florence, Italy.
authors: P
authors: P
authors: Geppetti
authors: E
authors: E
authors: Theodorsson-Norheim
authors: G
authors: G
authors: Ballerini
authors: M
authors: M
authors: Alessandri
authors: C A
authors: CA
authors: Maggi
authors: P
authors: P
authors: Santicioli
authors: F
authors: F
authors: Amenta
authors: M
authors: M
authors: Fanciullacci
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D004600:Eledoisin / Q000032:analysis; D006168:Guinea Pigs; D007158:Immunologic Techniques; D051379:Mice; D015288:Neurokinin A; D015287:Neurokinin B; D009479:Neuropeptides / Q000032:analysis*; D051381:Rats; D013045:Species Specificity; D013373:Substance P / Q000032:analysis; D015320:Tachykinins; D013950:Thymus Gland / Q000032:analysis*
chemical_list: D009479:Neuropeptides; D015320:Tachykinins; C045206:neuropeptide K; D013373:Substance P; D004600:Eledoisin; D015288:Neurokinin A; D015287:Neurokinin B; D002211:Capsaicin