title: Alpha-interferon therapy for lymphoproliferative disorders developing in two children following bone marrow transplants.
abstract: Two children developed lymphoproliferative processes following marrow transplantation. One of the two lymphoproliferative processes was documented to be Epstein-Barr virus (EBV)-associated. Both children received an extended course of alpha-interferon and gammaglobulin and responded with the disappearance of the lymphoproliferative process. Side effects from the alpha-interferon were minimal. Previous experience with EBV-associated lymphoproliferative processes following marrow transplantation have been usually fatal. This report further substantiates that alpha-interferon has a role in the treatment of EBV-associated lymphoproliferative processes following marrow transplantation.
authors: Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
authors: M E
authors: ME
authors: Trigg
authors: P
authors: P
authors: de Alarcon
authors: S
authors: S
authors: Rumelhart
authors: M
authors: M
authors: Holida
authors: R
authors: R
authors: Giller
mesh_terms: D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D004854:Herpesvirus 4, Human; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D014412:Tumor Virus Infections / Q000150:complications / Q000628:therapy; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D007370:Interferon Type I; D005719:gamma-Globulins