[Histamine-releasing action of x-ray contrast media in rats in vivo].
The effect of roentgen contrast media (RCM)--50% bilignost, 76% triombrast, 80% iodamide-380, on degranulation of peritoneal mast cells in rats was studied. It was found that 20 minutes after intravenous injections of RCM the content of intracellular histamine significantly decreased. This effect depended on the drug dose and increased in the order: triombrast, iodamide, triiotrast, bilignost. Different sensitivity of animals to the histamine-releasing effect of RCM was detected by using the nonparametric method of mathematical statistics. The number of "sensitive" animals was 50-75%.
Napolov
Iu K
IuK
Zanina
E N
EN
Panov
V O
VO
Shimanovskiĭ
N L
NL
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000032:analysis; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000032:analysis / Q000187:drug effects; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence
D003287:Contrast Media; D006632:Histamine
Issledovanie gistaminvysvobozhdaiushchego deĭstviia rentgenokontrastnykh sredstv u krys in vivo.