title: Proliferative cell index in endometrial adenocarcinoma of different nuclear grades.
abstract: Proliferative cell indices (PCI) in 20 cases of endometrial adenocarcinoma were obtained by staining DNA polymerase alpha. The PCI ranged from 11.1 to 42.1, averaging 24.7 +/- 8.7. Four cases of stage III all exhibited fairly large PCI (30.4-32.9). In contrast, in 16 cases of stage I the values were spread over a wide range. In 13 cases with histological grade (HG) 1 of stage I, larger PCI were obtained in the nuclear grade (NG) 2 group; the mean PCI values of HG 1-NG 1 and HG 1-NG 2 were 16.5 +/- 4.6 and 25.6 +/- 5.2, respectively. Because of the good correlation between PCI and HG or NG, PCI may be useful as an additional prognostic factor in endometrial adenocarcinoma, especially in stage I cases.
authors: Department of Obstetrics and Gynecology, Nagoya National Hospital.
authors: M
authors: M
authors: Mushika
authors: K
authors: K
authors: Shibata
authors: T
authors: T
authors: Miwa
authors: Y
authors: Y
authors: Suzuoki
authors: T
authors: T
authors: Kaneda
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology*; D000328:Adult; D000368:Aged; D002455:Cell Division; D002467:Cell Nucleus / Q000201:enzymology; D003593:Cytoplasm / Q000201:enzymology; D004257:DNA Polymerase II / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011379:Prognosis; D013194:Staining and Labeling; D014594:Uterine Neoplasms / Q000201:enzymology / Q000473:pathology*
chemical_list: D004257:DNA Polymerase II