Antiarrhythmic plasma concentrations of NIK-244 on canine ventricular arrhythmias.
Using two-stage coronary ligation-, digitalis-, and epinephrine (EPI)-induced canine ventricular arrhythmias, we examined antiarrhythmic effects of NIK-244 and determined the minimum effective plasma concentration for each arrhythmia model. NIK-244 suppressed coronary ligation- and digitalis-induced arrhythmias, and the minimum effective plasma concentrations for arrhythmias induced by 24-h and 48-h coronary ligation and digitalis were 0.41 +/- 0.10 (by 1 mg/kg i.v.), 0.70 +/- 0.13 (by 1 mg/kg i.v.), and 0.21 +/- 0.08 (by 0.5 mg/kg i.v.) microgram/ml, respectively (mean +/- SD of the mean, n = 6). The concentration for digitalis-induced arrhythmia was significantly lower than those for coronary ligation arrhythmias. NIK-244 was not effective on EPI arrhythmia, and 1 mg/kg worsened the arrhythmia to ventricular fibrillation in three of six dogs. This pharmacologic profile is similar to those of disopyramide, procainamide, and SUN 1165. Since NIK-244 had no deleterious effects on blood pressure and sinus node activity, its clinical usefulness is expected.
Hashimoto
K
K
Department of Pharmacology, Yamanashi Medical College, Japan.
Matsuzaki
T
T
Haruno
A
A
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004562:Electrocardiography; D004837:Epinephrine; D010042:Ouabain
D000889:Anti-Arrhythmia Agents; D010042:Ouabain; D004837:Epinephrine