Association between CAM 5.2 and anti-CD1a reactivity in lymph nodes and gastrointestinal tract epithelium.
Immunocytochemical studies, using the antibodies CAM 5.2 and NA1/34 (CD1a), were performed on normal lymphoid tissue and malignant lymphomas. A population of dendritic cells in the paracortex of lymph nodes and in T cell lymphomas reacted with both antibodies. Colocalisation with antibodies was also found in gastrointestinal epithelium. Immune blotting shows that the likely basis of this reactivity is a 12 kilodalton peptide which is recognised by both antibodies. This is almost certainly the beta t peptide which has been described as the light chain of CD1a.
Jack
A S
AS
Department of Pathology, University of Leeds.
Grigor
I
I
O'Brien
C J
CJ
McMeekin
W
W
Lewis
F
F
McNicol
A M
AM
D000911:Antibodies, Monoclonal / Q000276:immunology*; D018949:Antigens, CD1; D000943:Antigens, Differentiation / Q000276:immunology*; D003106:Colon / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D013270:Stomach / Q000276:immunology*; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D000943:Antigens, Differentiation; D000939:Epitopes