[Palliative treatment of malignant stenoses of the esophagus and cardia: laser therapy versus laser + high-dose-rate Iridium 192 afterloading therapy. A prospective randomized study].
In order to compare the local efficiency of two different therapy modalities, 37 patients with advanced inoperable tumors of esophagus and cardia were evaluated hitherto in a prospective randomized study. Twenty patients received an exclusive laser treatment, 17 were additionally submitted to three high-dose-rate iridium-192 afterloading irradiations (single dose at the reference point 1 cm radially to the source: 7 Gy). In both groups, 15 patients died whose survival times were not different (125 versus 130 days), however, a beneficial influence was exerted by the afterloading therapy with respect to the duration of the palliative effect (67 versus 28 days) and the hospitalization time (25 versus 48 days).
Ries
G
G
Institut für Strahlentherapie und Radiologische Onkologie, Technischen Universität München.
Töpfer
M
M
Hagenmüller
F
F
Sander
C
C
Sander
R
R
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery; D002299:Cardia; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D004940:Esophageal Stenosis / Q000209:etiology; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage*; D053685:Laser Therapy; D008297:Male; D010166:Palliative Care; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000532:radiotherapy* / Q000601:surgery
D007496:Iridium Radioisotopes
Palliativbehandlung maligner Stenosen des Osophagus und der Kardia: Lasertherapie versus Laser + High-dose-rate-Iridium-192-Afterloading-Therapie. Eine prospektive und randomisierte Studie.