Cyclosporin A and pressor responsiveness in sheep.
Pressor response to graded infusion of angiotensin II, noradrenaline, arginine-vasopressin, and serotonin and blood pressure change following indomethacin, an inhibitor of cyclooxygenase, were examined in conscious sheep, before and during the development of cyclosporin A-induced hypertension. Cyclosporin caused an increase in mean blood pressure from 68 +/- 2 to 82 +/- 3 mm Hg (p less than 0.001) and in heart rate from 67 +/- 4 to 91 +/- 4 beats/min (p less than 0.001). Pressor and heart rate responses to all substances tested were not changed by cyclosporin treatment suggesting that changes in pressor responsiveness are unlikely to be involved in the development of cyclosporin hypertension in sheep.
de Lima
J J
JJ
Department of Nephrology, Royal Melbourne Hospital, Parkville, Australia.
Bennett
W M
WM
Coghlan
J P
JP
McDougall
J G
JG
Tresham
J J
JJ
Whitworth
J A
JA
Scoggins
B A
BA
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003524:Cyclosporins / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood / Q000652:urine; D012701:Serotonin / Q000494:pharmacology; D012756:Sheep; D012964:Sodium / Q000097:blood / Q000652:urine; D014563:Urodynamics / Q000187:drug effects
D003524:Cyclosporins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D012701:Serotonin; D012964:Sodium; D011188:Potassium; D009638:Norepinephrine