[The effect of allopurinol on the synthesis of adenine nucleotides and ribonucleic acid from inosine via a salvage pathway in the brain of rats].
The authors investigated in experiments on rats the action of allopurinol and isoproterenol on the metabolism of adenine nucleotides and the total fraction of ribonucleic acids in the brain, liver heart and kidneys. It was revealed that allopurinol enhances the synthesis of adenine nucleotides from administered inosine in the brain and liver of rats. In the heart and kidneys allopurinol did not affect the synthesis of these compounds. Isoproterenol has a more marked effect on the metabolism of adenine nucleotides in the heart only: it reduced the amount of adenine nucleotides and enhanced their synthesis from inosine. It is assumed that the protective effect of allopurinol on the restoration of the reduced amount of these substances in brain and liver after their ischaemization could take place also by their increased resynthetization from accumulated inosine.
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D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D007288:Inosine / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D000227:Adenine Nucleotides; D007288:Inosine; D012313:RNA; D000493:Allopurinol; D007545:Isoproterenol
Vplyv alopurinolu na syntézu adenínových nukleotidov a ribonukleových kyselín v mozgu potkanov pomocnou cestou z inozínu.