title: Evidence for a T-cell related factor as the cause of demyelination in mice following Semliki Forest virus infection.
abstract: Patchy demyelination throughout the central nervous system, including the optic nerve, is known to occur following infection with Semliki Forest virus (SFV) in Swiss/A2G mice. An increase in the fast axonal transport of protein in optic nerves occurred before they showed signs of demyelination in Swiss/A2G mice, heterozygous nude mice and nude mice reconstituted with T-cells. SFV infection, however, caused neither an increase in the fast axonal transport of protein, nor optic nerve demyelination in T-cell-deficient nude mice. Thus, the increase in both axonal transport and demyelination following SFV infection appear to be T-cell-mediated events, rather than direct effects of the virus.
authors: Vision Research Unit, Sherrington School, Rayne Institute, St. Thomas' Hospital, London, U.K.
authors: H G
authors: HG
authors: Jenkins
authors: E M
authors: EM
authors: Tansey
authors: F
authors: F
authors: Macefield
authors: H
authors: H
authors: Ikeda
mesh_terms: D000818:Animals; D001370:Axonal Transport; D003711:Demyelinating Diseases / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009900:Optic Nerve / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D011392:Proline / Q000378:metabolism; D012672:Semliki forest virus; D013601:T-Lymphocytes / Q000276:immunology*; D014036:Togaviridae Infections / Q000276:immunology* / Q000378:metabolism
chemical_list: D011392:Proline