title: Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis.
abstract: Synovial tissues from patients with ankylosing spondylitis or reactive arthritis were examined by an immunoperoxidase technique, using antisera to synthetic peptides representing antigens shared between HLA-B27.1 and Klebsiella pneumoniae nitrogenase. With either antiserum, all HLA-B27+ patients with synovial inflammation showed strong immunoperoxidase staining in synovial lining cells, vascular endothelium, and infiltrating inflammatory cells. These findings indicate that antigens showing cross-reactivity between HLA-B27.1 and Klebsiella nitrogenase epitopes are strongly expressed within inflamed synovial tissues of HLA-B27+ patients.
authors: Department of Medicine, University of Florida School of Medicine, Gainesville.
authors: G
authors: G
authors: Husby
authors: N
authors: N
authors: Tsuchiya
authors: P L
authors: PL
authors: Schwimmbeck
authors: A
authors: A
authors: Keat
authors: J A
authors: JA
authors: Pahle
authors: M B
authors: MB
authors: Oldstone
authors: R C
authors: RC
authors: Williams
mesh_terms: D001168:Arthritis / Q000276:immunology; D002358:Cartilage, Articular / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D015235:HLA-B Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D009591:Nitrogenase / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D013582:Synovial Fluid / Q000276:immunology
chemical_list: D000939:Epitopes; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D007371:Interferon-gamma; D009591:Nitrogenase