Transfollicular percutaneous absorption. Skin model for quantitative studies.
Theoretically percutaneous absorption comprises two components: the transepidermal route and the transappendageal route, so-called 'shunt' diffusion. The relative importance of 'shunt' diffusion was investigated with a model of appendage-free skin. After treatment with 60 degrees C water for exactly 1 min, hairless dorsal rat skin regrows as a continuous epidermis. We present preliminary results of hydrocortisone diffusion in vitro, in appendage-free skin relative to normal skin. With intact skin under our experimental conditions, the steady-state flux and the total diffusion in 24 h were 50-fold larger.
Illel
B
B
Centre International de Recherches Dermatologiques (C.I.R.D.), Valbonne, France.
Schaefer
H
H
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D006197:Hair / Q000473:pathology / Q000502:physiology*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D051381:Rats; D011923:Rats, Nude; D012867:Skin / Q000473:pathology; D012869:Skin Absorption; D014870:Water Loss, Insensible
D006854:Hydrocortisone