Early and long-term toxicity in the management of advanced germ cell testicular tumors.
47 patients with advanced germ cell testicular tumors were treated with combination chemotherapy, cis-platinum, vinblastine and bleomycin (PVB). All patients were reexamined on average 2.5 years after the end of treatment. Persistent mild long-term toxicity affecting the lungs, kidneys and peripheral nerve system was found in about one third of the patients. In addition, 32 patients who had received radiation therapy of seminoma were reexamined. Objective long-term toxicity was rare. However, possible damage to chromosomes and spermatogenesis has to be kept in mind.
Strohmeyer
T
T
Department of Urology, University of Düsseldorf, FRG.
Geiser
M
M
Ackermann
R
R
Mumperow
E
E
Hartmann
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000532:radiotherapy; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011878:Radiotherapy / Q000009:adverse effects; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin