Saframycin Mx1, a new natural saframycin isolated from a myxobacterium.
A new natural saframycin was discovered in the culture broth of the myxobacterium, Myxococcus xanthus strain Mx x48. The fermentation and isolation of the antibiotic are described. The name, saframycin Mx1, is proposed. The compound appears to interact with cellular DNA.
Irschik
H
H
Gesellschaft für Biotechnologische Forschung, Arbeitsgruppe Mikrobielle Sekundärstoffe, Braunschweig, FRG.
Trowitzsch-Kienast
W
W
Gerth
K
K
Höfle
G
G
Reichenbach
H
H
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D003470:Culture Media; D004269:DNA, Bacterial / Q000096:biosynthesis; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007546:Isoquinolines / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D009231:Myxococcales / Q000378:metabolism*; D012329:RNA, Bacterial / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003470:Culture Media; D004269:DNA, Bacterial; D007546:Isoquinolines; D012329:RNA, Bacterial; C057297:saframycin Mx1