Hepatocellular carcinoma with normal adjacent liver. Hepatitis B virus DNA status.
We investigated hepatitis B virus (HBV) DNA status in the liver of 22 patients with hepatocellular carcinoma (HCC) developed on a non-cirrhotic, histologically normal liver tissue. HBV serological markers were present in 2 of the 22 subjects. HBV DNA sequences were identified in the liver of only 5 of the 22 patients with HCC. Evidence for clonal expansion of HBV-infected cells was found for one HBsAg-positive subject. This study indicates a much lower rate of HBV DNA positivity in the group of HCC developed on histologically normal livers as compared to that observed in HCC with liver cirrhosis.
Marcellin
P
P
Unité U 163-Institut Pasteur, Paris, France.
Thiers
V
V
Degott
C
C
Franco
D
D
Belghitti
J
J
Castaing
D
D
Fagniez
P
P
Zafrani
S
S
Benhamou
J P
JP
Bismuth
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000032:analysis*; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D000509:alpha-Fetoproteins