cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes.
We have isolated four cDNAs encoding the entire preproprotein of prostate specific antigen from human prostatic cDNA libraries. Comparison of the coding regions of prostate specific antigen with human pancreatic kallikrein (1-3) and human glandular kallikrein (4) showed 73%-84% nucleotide and 61-77% amino acid homologies, respectively, between these enzymes. Also the 3' noncoding regions of these genes were conserved. The close resemblance of prostate specific antigen, a marker for prostatic cancer, to glandular kallikrein suggests related immunogenic properties for them.
Henttu
P
P
Biocenter, University of Oulu, Finland.
Vihko
P
P
D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000302:isolation & purification; D001483:Base Sequence; D004247:DNA / Q000302:isolation & purification*; D006801:Humans; D007610:Kallikreins / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D017430:Prostate-Specific Antigen; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000032:analysis; D011498:Protein Precursors / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid
D000951:Antigens, Neoplasm; D011498:Protein Precursors; D012333:RNA, Messenger; D004247:DNA; D007610:Kallikreins; D017430:Prostate-Specific Antigen