Stretch-activated ion channels in cultured mesangial cells.
Membrane stretch, delivered by negative pressures in cell-attached patch pipettes, activated single-channel ionic currents in cultured mesangial cells. Channel opening probabilities were directly related to degree of suction, with threshold for activation being 5-10 mm Hg. The stretch-activated channels were permeable to Na+, K+, as well as Cl-, having conductances averaging 62 +/- 17 pS. These channels may represent a cellular mechano-reflex in mesangial cells.
Craelius
W
W
Department of Medicine, Veterans' Administration Medical Center, Brooklyn, NY 11209.
el-Sherif
N
N
Palant
C E
CE
D000818:Animals; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D004553:Electric Conductivity; D005920:Glomerular Mesangium / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials; D051381:Rats; D011919:Rats, Inbred Strains
D007473:Ion Channels