Polyamines in rat liver during experimental inflammation.
The effect of turpentine, a chemical inflammatory agent, on polyamine synthesis has been studied. Ornithine decarboxylase activity is markedly increased in liver 6 hrs after subcutaneous injection of turpentine, and then decreases. No significant modification is observed in S-adenosylmethionine decarboxylase. Putrescine injected prior to turpentine prevents this increase. Putrescine, spermidine and spermine concentrations are all increased following turpentine, but with different patterns: spermidine alone keeps increasing for 50 hours. Putrescine and spermidine injected prior to turpentine partially counteract the increase of serum alpha 2-macroglobulin, which is believed to be a marker of inflammation.
Colombatto
S
S
Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy.
Fasulo
L
L
Grillo
M A
MA
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D014425:Turpentine / Q000633:toxicity; D000511:alpha-Macroglobulins / Q000097:blood
D011073:Polyamines; D000511:alpha-Macroglobulins; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase; D013095:Spermidine; D011700:Putrescine; D014425:Turpentine