Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion.
5'-N-ethylcarboxamideadenosine (NECA) greater than 2-chloroadenosine greater than adenosine greater than N6-(R-phenyl-isopropyl)-adenosine (R-PIA) inhibited in vitro anti-IgE-induced histamine and peptide leukotriene C4 (LTC4) release from human basophils in a concentration-dependent fashion. Micromolar concentrations of adenosine, NECA and R-PIA potentiated the anti-IgE-stimulated release of histamine and LTC4 from human lung parenchymal mast cells. Submillimolar concentrations of adenosine, NECA and R-PIA inhibited in a concentration dependent manner the release of histamine and prostaglandin D2 (PGD2) from skin mast cells challenged with anti-IgE. These results demonstrate marked heterogeneity of the modulatory effect exerted by adenosine on mediator release from human basophils and mast cells.
Marone
G
G
Department of Medicine University of Naples, Second School of Medicine, Italy.
Cirillo
R
R
Genovese
A
A
Marino
O
O
Quattrin
S
S
D015762:2-Chloroadenosine / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000328:Adult; D001491:Basophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008168:Lung / Q000166:cytology; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D015230:Prostaglandin D2 / Q000494:pharmacology; D013189:SRS-A / Q000378:metabolism; D012867:Skin / Q000166:cytology; D014665:Vasodilator Agents
D013189:SRS-A; D014665:Vasodilator Agents; D015762:2-Chloroadenosine; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D007073:Immunoglobulin E; D000241:Adenosine; D015230:Prostaglandin D2