[A decrease in the content of immunoreactive alpha- and gamma-endorphins in the blood and the suppression of their hypersecretion under the influence of dexamethasone in emotional stress in monkeys].
Daily administration of 12 mg of dexamethasone to monkeys during 10 days resulted in decrease of the levels of alpha- and gamma-endorphins and cortisol 7 days after the first injection. The titers of these peptides in plasma of monkeys. exposed to two hours of immobilization stress were elevated twice above basal levels. The maximum elevation took place 6 hours after the beginning of immobilization. This effect wasn't detected in monkeys, which received 12 mg of dexamethasone during 10 days.
Dmitriev
A D
AD
Chirkova
S K
SK
Dmitrieva
O F
OF
Tennov
A V
AV
Shchurin
M R
MR
D000208:Acute Disease; D000818:Animals; D003864:Depression, Chemical; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004723:Endorphins / Q000097:blood* / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010215:Papio; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood* / Q000188:drug therapy; D013997:Time Factors; D018822:alpha-Endorphin; D018823:gamma-Endorphin
D004723:Endorphins; D018822:alpha-Endorphin; D018823:gamma-Endorphin; D003907:Dexamethasone; D006854:Hydrocortisone
Umen'shenie soderzhaniia immunoreaktivnykh al'fa- i gamma-éndorfinov v krovi i podavlenie ikh gipersekretsii pod vliianiem deksametazona pri émotsional'nom stresse u obez'ian.