title: Myelin basic protein transcriptional activity in myelin-deficient mutant mice.
abstract: Myelin-deficient (mld) mice present two tandem myelin basic protein genes, with the upstream gene containing an inversion (Popko et al., Neuron 1: 221, 1988). Detailed analysis of the transcriptional activity of various regions of the gene showed that all portions of the MBP gene are transcribed in mld mice. Consequently, we propose that the low levels of MPB mRNA observed in mld mice are due to post-transcriptional events.
authors: J M
authors: JM
authors: Roch
authors: M
authors: M
authors: Tosic
authors: A
authors: A
authors: Roach
authors: J M
authors: JM
authors: Matthieu
mesh_terms: D000818:Animals; D005091:Exons; D005815:Genetic Code; D051379:Mice; D008818:Mice, Neurologic Mutants; D004676:Myelin Basic Protein / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D004676:Myelin Basic Protein; D012333:RNA, Messenger