Volume regulatory mechanisms of human platelets.
Platelets were found to defend themselves against hypoosmotic swelling by a regulatory volume decrease mechanism, similar to that of T-lymphocytes. An oligomycin C sensitive Cl- -channel and a Ca2+-dependent, quinine- and trifluoperazine-sensitive K+-channel play a significant role in the process: platelets lose K+ and Cl- (and consequently water) through these. Activation of platelets accelerates the volume regulatory mechanism in spite of the fact that the Na+/H+ exchange process, activated simultaneously, works against volume decrease. The most rapid volume regulation was observed in activated platelets with inhibited Na+/H+ exchange process.
Szirmai
M
M
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Sarkadi
B
B
Szász
I
I
Gárdos
G
G
D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D002712:Chlorides / Q000097:blood; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D009997:Osmotic Pressure; D011188:Potassium / Q000097:blood
D002712:Chlorides; D007473:Ion Channels; D011188:Potassium