Different patterns of immunolocalization of calcitonin gene-related peptide and substance P in sympathetic ganglia of normotensive and genetically hypertensive rats.
Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity were investigated in the superior cervical ganglion of normotensive and genetically hypertensive Otago Wistar rats by an immunoperoxidase method. CGRP- and SP-positive varicose axons invested separate subpopulations of ganglion cells, neither of which contained neuropeptide Y. The densities of CGRP axons were similar in normotensive and hypertensive rats while the numbers of SP axons were several times higher in the hypertensive strain. Decentralization of the ganglion or chronic capsaicin treatment removed all immunoreactive terminals, indicating that both axon populations are likely to be collaterals from thoracic sensory afferents.
Gurusinghe
C J
CJ
Department of Physiology, University of Melbourne Medical Centre, Vic., Australia.
Bell
C
C
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide