Acute toxicity of hexachlorocyclohexane (HCH) in mice, rats, rabbits, pigeons and freshwater fish.
Technical Hexachlorocyclohexane (HCH) is a mixture of several stereo isomers, whose percent content has shown wide variation in different samples. In spite of its importance and extensive use over the last 3 decades, basic information on acute toxicity of HCH in various species of animals seems to be either lacking or very fragmentary. The present report with information on acute toxicity of technical HCH in mice, rats, rabbits, pigeon and freshwater fish therefore has significance. The study examines the role of modulating factors, such as chemical composition of technical HCH with different isomers, the sex of animals, route of exposure and nature of the vehicle or solvent, in the overall characterization of HCH-induced toxicity.
Dikshith
T S
TS
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Raizada
R B
RB
Singh
R P
RP
Kumar
S N
SN
Gupta
K P
KP
Kaushal
R A
RA
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D010856:Columbidae; D005260:Female; D005399:Fishes; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats
D001556:Hexachlorocyclohexane