The granulocyte factor abrogates the alloantigen-induced delayed type hypersensitivity suppression in mice.
Adherent granulocytes secrete granulocyte factor (GF) in the course of the first 60 min of adherence. GF abolishes suppressor cell generation in mice induced by intravenous injection of irradiated allogeneic lymphoid cells. The effect of such induced suppressors was measured in delayed type hypersensitivity reaction induced by subcutaneously injected irradiated allogeneic spleen cells and evaluated in the foodpad test. Suppressor cell induction or GF treatment had no effect on antigen- or phytohaemagglutinin-induced production of migration inhibitory factor.
Tchórzewski
H
H
Department of Pathophysiology, Institute of Basic Medical Sciences, Lódź.
Kocur
E
E
Wojtkowiak
Z
Z
Majewska
E
E
Pokoca
L
L
D000818:Animals; D002469:Cell Separation; D003115:Colony-Stimulating Factors / Q000276:immunology* / Q000302:isolation & purification; D016179:Granulocyte Colony-Stimulating Factor; D006098:Granulocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007519:Isoantigens / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D003115:Colony-Stimulating Factors; D007519:Isoantigens; D016179:Granulocyte Colony-Stimulating Factor