title: Cytokeratin expression in cervical epithelium: an immunohistological study of normal, wart virus-infected and neoplastic tissue.
abstract: In this study using a panel of anticytokeratin antibodies and an indirect immunoperoxidase method, we examined cervical squamous epithelia including mature stratified epithelium, immature squamous metaplasia, CIN 1, 2 and 3, wart virus infection and squamous carcinoma. Changes from the normal patterns of staining were inconsistently seen in CIN 1 and 2, but in CIN 3 the changes were more marked, and consisted of a loss of stratification of the staining pattern and a patchy reduction in staining. Invasive carcinomas showed a similar staining pattern to CIN 3 lesions.
authors: Department of Gyaecological Oncology, Queen Elizabeth Hospital, Gateshead, UK.
authors: J R
authors: JR
authors: Whittaker
authors: A M
authors: AM
authors: Samy
authors: J P
authors: JP
authors: Sunter
authors: D P
authors: DP
authors: Sinha
authors: J M
authors: JM
authors: Monaghan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism*; D027383:Papillomaviridae; D014412:Tumor Virus Infections / Q000378:metabolism* / Q000473:pathology; D002577:Uterine Cervical Diseases / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D007633:Keratins