Unique Ia epitopes of T cells (Iat) are involved in the recognition of stimulator cells in the allo-MLR.
Anti-Iat monoclonal antibodies (mAbs) were found to block the recognition phase of allogeneic mixed lymphocyte reaction (allo-MLR) by reacting with responder T cells but not stimulators. The inhibitory pattern was dependent on the major histocompatibility complex (MHC) of both the responder and stimulator cells. Certain molecules, including IgVH and I-J of stimulator cells were also important. It is suggested that Iat epitopes on alloreactive T cells may serve as a marker of a novel type of a T cell recognition site for Ia. The model of T cell receptor complex with two distinct sites for MHC recognition is proposed.
Uracz
W
W
Department of Clinical Immunology, Copernicus Medical School, Cracow, Poland.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies; D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell