Fluosol and experimental spinal cord ischemia.
Spinal cord ischemia was produced by temporary aortic occlusion for 12.5 min in 27 rabbits. Animals were divided into three groups: Group A received Fluosol DA 20% and 100% oxygen; Group B Fluosol and room air only, and Group C Dextran 40 and 100% oxygen. There was no difference in neurological outcome or in the extent and severity of histologically documented infarction of the spinal cord in the three groups. There was also no difference between these groups and untreated controls previously studied by us.
Kolluri
S
S
Department of Surgery (Neurosurgery), Massachusetts General Hospital/Harvard Medical School, Boston 02114.
DeGirolami
U
U
Heros
R
R
Vacanti
F
F
Zervas
N
N
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use; D005260:Female; D005466:Fluorocarbons / Q000627:therapeutic use*; D007511:Ischemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010100:Oxygen / Q000627:therapeutic use; D010243:Paralysis / Q000209:etiology / Q000473:pathology; D011817:Rabbits; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology
D001802:Blood Substitutes; D003911:Dextrans; D005466:Fluorocarbons; C050455:fluosol; D010100:Oxygen