[Effect of double insertion of homogeneously stained regions in chromosome 1 of the house mouse on recombination frequency].
By means of genetic and cytogenetic analysis, the effect of cis heterozygosity for two insertions--Is(HSR; 1C5)1Icg and Is (HSR; 1E3)2Icg was studied. It was shown that the proximal point of Is is situated 8 cM distally from the ln gene. Crossing over is completely suppressed in the intermedial part of Chr. 1, where a single chiasma appears in normal mice. The frequency of double chiasmata in heterozygotes is significantly increased. They are localized at precentromeric and pretelomeric parts of Chr. 1. It is supposed that recombination block in the central region leads to a shift of the potential chiasmata in telomeric regions. This shifted telomeric chiasmata, in turn, allow the appearance of the second chiasmata in the centromeric region.
Ladygina
T Iu
TIu
Gorlov
I P
IP
Borodin
P M
PM
D000818:Animals; D002503:Centromere; D002875:Chromosomes; D003434:Crossing Over, Genetic; D004251:DNA Transposable Elements; D005819:Genetic Markers; D006579:Heterozygote; D051379:Mice; D011995:Recombination, Genetic; D013194:Staining and Labeling
D004251:DNA Transposable Elements; D005819:Genetic Markers
Vliianie dvoĭnoĭ insertsii gomogenno okrashivaemykh raĭonov v 1-ĭ khromosome domovoĭ myshi na chastotu rekombinatsii.