[Immunogenic activity of synthetic brucellosis antigens].
Experimental data obtained in this investigation indicate that the conjugation of Brucella protective antigen with a polymer carrier essentially increase the immunogenic properties of the antigen. Synthesized vaccinal preparations can be of interest for practical use, as these preparations, while inducing the development of intense immunity, do not impede the diagnosis of brucellosis by serological reactions. The comparative study of the conjugates of Brucella antigen with different carriers shows that the conjugated preparation obtained on the basis of modified dextran possesses high protective potency, which makes it possible to regard this carrier as very promising for further use.
Petrov
R V
RV
Khaitov
R M
RM
Ignatov
P I
PI
Nekrasov
A V
AV
Sviridov
B D
BD
D000818:Animals; D000917:Antibody Formation; D002004:Brucella Vaccine / Q000276:immunology*; D003911:Dextrans; D006168:Guinea Pigs; D012698:Serologic Tests; D014612:Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D002004:Brucella Vaccine; D003911:Dextrans; D014612:Vaccines; D014614:Vaccines, Synthetic
Izuchenie immunogennoĭ aktivnosti iskusstvennykh brutselleznykh antigenov.