Dextran-induced gastric acid secretion in rats.
Dextran C (M.W. 60,000-70,000) employed as plasma expander in the treatment of hypovolemic shock, and which is known to induce histamine release from rat mast cells was studied for its effect on gastric acid secretion in rats. Dextran at doses even lower than the therapeutic dose in man (8-250 mg/kg) induced significant gastric acid secretion in intact anaesthetized rats. Pretreatment of the animals with 1 mg/kg cimetidine significantly reduced the increase in acid secretion while a higher dose of 10 mg/kg completely abolished the effect. The result thus suggests that dextran-induced gastric acid secretion in rats is mediated through histamine release.
Ezeamuzie
I C
IC
Department of Pharmacology, College of Health Sciences, University of Port Harcourt, Nigeria.
Nwankwoala
R N
RN
Emenike
O
O
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006636:Histamine Release; D051381:Rats; D013268:Stimulation, Chemical
D003911:Dextrans; D002927:Cimetidine