title: Pluronic polyol: a potential alloplastic keratorefractive material.
abstract: Pluronic polyol possesses a negative temperature coefficient of gelation; it is liquid at low temperatures and gelatinous at high temperatures. Pluronic F108 was evaluated as a potential material for alloplastic keratorefractive surgery: 0.3 ml of the material in a liquid state was injected into a surgically prepared axial 7 mm mid-stromal corneal bed in 17 rabbits; fellow eyes in the rabbits were sham-operated but not injected. Postoperatively, rabbits were clinically evaluated with biomicroscopy, keratometry, and pachymetry at regular intervals up to three months following surgery. Animals were periodically sacrificed and corneas were studied by light and electron microscopy. The material appeared to be well tolerated by the cornea. Both control and pluronic eyes showed an initial increase in corneal thickness peaking at one week postoperatively, with return to near normal levels by the end of the third week. Refractive flattening of approximately three diopters was noted in the experimental group, while no change was seen in the control group.
authors: Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27514.
authors: J P
authors: JP
authors: Kim
authors: R L
authors: RL
authors: Peiffer
authors: R E
authors: RE
authors: Holman
mesh_terms: D000818:Animals; D003229:Conjunctival Diseases / Q000139:chemically induced; D003315:Cornea / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure; D003319:Corneal Stroma / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D006940:Hyperemia / Q000139:chemically induced; D007267:Injections; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic / Q000139:chemically induced; D011060:Poloxalene / Q000008:administration & dosage* / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D019736:Prostheses and Implants; D012030:Refractive Errors / Q000628:therapy*
chemical_list: D011092:Polyethylene Glycols; D011060:Poloxalene