The effect of acute treatment with two goitrogens on plasma thyroid hormones, testosterone and testicular morphology in adult male rats.
1. Hypothyroidism was induced in adult male rats by treatment with either iopanoic acid (IOP) or propylthiouracil (PTU). The hypothyroid animals were maintained for a period of 4 weeks. 2. The IOP and PTU treatments produced drastically different thyroid hormone profiles during the treatment period. 3. Serum testosterone levels were not significantly different from controls in either of the goitrogen-treated groups. 4. Testes weights and germ cell populations were not significantly different from controls in either of goitrogen treated groups. 5. Seminiferous tubule morphology showed no significant variation in lumen size or basal lamina structure in either of the treatment groups when compared to the controls.
Weiss
S R
SR
Department of Biological Sciences, Texas Tech University, Lubbock 79409.
Burns
J M
JM
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D007480:Iopanoic Acid / Q000494:pharmacology; D008297:Male; D009994:Osmolar Concentration; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013076:Sperm Count; D013737:Testis / Q000033:anatomy & histology*; D013739:Testosterone / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013956:Antithyroid Agents; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013739:Testosterone; D011441:Propylthiouracil; D007480:Iopanoic Acid; D013974:Thyroxine