A 115-kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi membranes.
Band 3 multigene family consists of several distinct but structurally related polypeptides which are probably involved in the transport of anions across the plasma membrane of both erythrocytes and nonerythroid cells. A novel member of this family of polypeptides that resides in the Golgi complex was identified with antibodies to Band 3. The Golgi antigen had a larger molecular size and was antigenically distinct from Band 3 in the amino-terminal domain. It was expressed most prominently in cells that secrete large amounts of sulfated proteins and proteoglycans. This polypeptide may participate in sulfate transport across Golgi membranes.
Kellokumpu
S
S
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Neff
L
L
Jämsä-Kellokumpu
S
S
Kopito
R
R
Baron
R
R
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology*; D003001:Cloning, Molecular; D006056:Golgi Apparatus / Q000648:ultrastructure*; D007124:Immunoenzyme Techniques; D007425:Intracellular Membranes / Q000648:ultrastructure*; D007473:Ion Channels / Q000648:ultrastructure*; D008970:Molecular Weight; D051381:Rats
D001457:Anion Exchange Protein 1, Erythrocyte; D007473:Ion Channels