[Effect of i.v. gamma-globulin on T lymphocytes and on interleukin-2 secretion in infectious mononucleosis].
Biological and clinical effects of i.v. administration of gamma-globulin (0.9-1.5 g/kg) to 9 patients with infectious mononucleosis have been compared with the effects observed in 4 untreated patients. An increase of OKT4/OKT8 ratio has been measured in treated cases whereas this ratio remains low in untreated patients. Interleukin-2 secretion by stimulated lymphocytes increases also in treated patients but not in untreated ones. On the other hand gamma-globulin inhibits in vitro the cytotoxic activity of lymphocytes from immune subjects. Clinically gamma-globulin i.v. had a beneficial effect on the course of the disease and on adenopathies. As infectious mononucleosis has usually a favourable outcome, this treatment should be restrained to severe or chronic cases.
Martin du Pan
R E
RE
Koechli
B
B
Martin du Pan
R C
RC
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology / Q000628:therapy*; D007376:Interleukin-2 / Q000378:metabolism*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000956:Antigens, Viral; D007376:Interleukin-2; D005719:gamma-Globulins
Effet de la gamma-globuline i.v. sur les lymphocytes T et sur la sécrétion d'Interleukine-2 dans la mononucléose infectieuse.