Enhanced erythrocyte aggregability in occlusive cerebrovascular disease.
We measured the rate of erythrocyte aggregation using our whole-blood aggregometer in 80 patients with occlusive cerebrovascular disease during the acute and chronic phases. We compared the data with values for 38 age-matched healthy controls. Mean +/- SD erythrocyte aggregability of the patients during both the acute phase (0.145 +/- 0.21/sec, n = 35) and the chronic phase (0.139 +/- 0.21/sec, n = 45) was higher than that in the controls (0.123 +/- 0.21/sec, n = 38; p less than 0.01). Erythrocyte aggregability was positively correlated with the plasma concentration of globulin and fibrinogen and inversely correlated with the albumin:globulin ratio. However, these correlations did not necessarily exclude the possibility that some unknown substance(s) released from ischemic tissue might enhance erythrocyte aggregability.
Tanahashi
N
N
Department of Neurology, Ashikaga Red Cross Hospital, Japan.
Gotoh
F
F
Tomita
M
M
Shinohara
T
T
Terayama
Y
Y
Mihara
B
B
Ohta
K
K
Nara
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000510:Alpha-Globulins / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000097:blood*; D002908:Chronic Disease; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005916:Globulins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism
D000510:Alpha-Globulins; D005916:Globulins; D012709:Serum Albumin; D005340:Fibrinogen