title: Seroconversion to human immunodeficiency virus (HIV) in persons attending an STD clinic in Copenhagen.
abstract: 1,182 males and 155 females attending an STD clinic from June 1984 to October 1985 were investigated for the presence of antibodies to human immunodeficiency virus (HIV). 348 (29.5%) of the males and 5 (3.2%) of the females were antibody positive (ab+). 237 of the males were initially antibody negative (ab-) and were tested more than once, and during a 16-month period 40 of these seroconverted from ab- to antibody positive. The mean follow-up period of these 40 patients was 7.1 months, and thus the seroconversion rate is estimated to be 2.4% per month. Samples from 37 of these were available for HIV antigen testing. 19 of the patients were antigen positive in the latest ab- sample and accordingly, 18 patients were antigen negative in the latest ab- sample. No difference was found between the mean follow-up periods of those with and those without HIV antigen in the latest ab- serum and the presence of HIV antigen in serum was not associated with symptoms of acute HIV infection. After 20 months of follow-up, none (0.0-8.8%, 97.5% confidence limits) of the 40 patients have developed AIDS or AIDS-related complex.
authors: Laboratory of Tumor Virology, Fibiger Institute, Copenhagen, Denmark.
authors: B O
authors: BO
authors: Lindhardt
authors: K
authors: K
authors: Ulrich
authors: J H
authors: JH
authors: Sindrup
authors: C
authors: C
authors: Avnstorp
authors: H
authors: H
authors: Fogh
authors: G L
authors: GL
authors: Wantzin
mesh_terms: D000293:Adolescent; D000328:Adult; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000453:epidemiology*; D006716:Homosexuality; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012749:Sexually Transmitted Diseases / Q000453:epidemiology