Aprotinin reduces hypothermic mortality--an experimental model.
In order to test the postulate that post-hypothermic damage may be caused by protease activation, the effect of the administration of aprotinin on hypothermic mortality was investigated in anaesthetized rabbits. A group of 6 animals received 40.000 KIU aprotinin intravenously prior to the induction of hypothermia by surface cooling and this was followed by a further 35.000 KIU each hour for 5 h. The animals were cooled to 29 degrees C and then rewarmed. A control group received equal volumes of physiological saline. The aprotinin treated animals survived, whereas all the control group died within 7 days, 5 of them within 24 h. The haemodynamic, biochemical and haematological changes in the two groups are reported.
Bhargava
N
N
Department of Anaesthesiology, Erasmus University, Rotterdam, The Netherlands.
Dhasmana
K M
KM
Banerjee
A K
AK
Faithfull
N S
NS
Fennema
M
M
Vermij
M
M
Erdmann
W
W
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001784:Blood Gas Analysis; D005260:Female; D006439:Hemodynamics; D007035:Hypothermia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009132:Muscles / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D011817:Rabbits
D007611:Aprotinin; D007770:L-Lactate Dehydrogenase; D010100:Oxygen