[Detection of functional changes in the myocardium after chemotherapy using radionuclide ventriculography in patients with testicular tumors].
Radionuclide ventriculography performed in a group of 26 patients with testicular tumors treated with the combinations PVB (cisplatinum, vinblastine, bleomycin) and PAV (cisplatinum, adriamycin, VP-16) showed in both groups at a virtually unchanged ejection fraction an increased diastolic and residual volume of the left ventricle, compensated by an increased systolic volume and higher heart rate. The functional changes develop more slowly after administration of the combination PAV and were found to persist in both groups for more than 2 years after termination of therapy. These changes do not become clinically manifest in patients with good myocardial function before onset of therapy, yet in patients with an a priori changed myocardial function they may develop into therapy complications.
Brousil
J
J
Foltýnová
V
V
Bĕlohlávek
O
O
Abrahámová
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D015635:Radionuclide Ventriculography; D013318:Stroke Volume / Q000187:drug effects; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use
D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin
Detekce funkcních zmĕn myokardu radionuklidovou ventrikulografií u nemocných s testikulárními nádory po chemoterapii.