[Effect of splenic cells sensitized with staphylococcal enterotoxin A on the metastasis of Lewis lung carcinoma in mice].
The effect of intact mouse spleen cells sensitized in vitro with staphylococcus aureus enterotoxin A (SEA) on spreading of mouse Lewis carcinoma was studied. A significant decrease in a number of metastases in the lungs and in the weight of the lungs was observed after multiple intrapulmonary inoculation of spleen cells treated with SEA for 6 hours. The effect was less marked after inoculation of the sensitized cells intraperitoneally or into the femoral muscle of the leg affected with the tumour. After multiple inoculations of the sensitized cells, the spleen cells of the treated animals develop the state of interferon hyporeactivity to SEA but not to PHA or NDV.
Shcheglovitova
O N
ON
Ezepchuk
Iu V
IuV
Orlova
T G
TG
D000818:Animals; D002277:Carcinoma / Q000276:immunology / Q000628:therapy*; D002478:Cells, Cultured; D004768:Enterotoxins / Q000494:pharmacology*; D007116:Immunization, Passive / Q000379:methods; D007372:Interferons / Q000096:biosynthesis / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors
D004768:Enterotoxins; C026066:enterotoxin A, Staphylococcal; D007372:Interferons
Vliianie kletok selezenki, sensibilizirovannykh stafilokokkovym énterotoksinom A, na metastazirovanie kartsinomy legkikh L'iuis u mysheĭ.