Effect of the proton pump inhibitor, NC-1300, on gastric mucus secretion in rats.
The effects of NC-1300 on gastric acid and mucus glycoprotein secretion were investigated in pylorus-ligated (4 h) rats. NC-1300 (30 mg/kg, intraduodenally) significantly inhibited gastric acid concentration more than 90%. The agent did not affect the total mucus glycoprotein output in the gastric juice, but caused by about 1.5 times denser mucus glycoprotein secretion than that in the control group. The amount of mucus glycoprotein in the mucous gel layer increased by about 1.4 times with this agent. Thus, NC-1300 not only inhibits acid secretion but also promotes mucus secretion, and this may explain its ability to protect the stomach against necrotizing agents.
Ohara
S
S
Department of Biochemistry, and Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Ohkawa
H
H
Ishihara
K
K
Hotta
K
K
Komuro
Y
Y
Okabe
H
H
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006023:Glycoproteins / Q000032:analysis / Q000378:metabolism; D006601:Hexoses / Q000032:analysis; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D009093:Mucus / Q000378:metabolism*; D009853:Omeprazole / Q000031:analogs & derivatives; D011522:Protons; D051381:Rats; D011919:Rats, Inbred Strains
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D006023:Glycoproteins; D006601:Hexoses; D007473:Ion Channels; D011522:Protons; C047874:gastric mucus glycoproteins; C048733:2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole; D009853:Omeprazole