title: Bindings of plasma proteins to streptococci of serological group L with special reference to their immunoglobulin G Fc-receptor activity.
abstract: Of 33 streptococcal cultures belonging to serological group L, all bound human immunoglobulin (Ig) G, fibrinogen, and fibronectin; 32 bound bovine IgG; 31 bound alpha 2-macroglobulin; 5 bound albumin; and none bound either haptoglobin or IgA. The binding sites for IgG could be isolated from the L streptococci by trypsinization and purified by affinity chromatography on human IgG-Sepharose. The purified Fc receptors reacted with IgG subclasses 1, 2, 3, 4 of humans, 1 and 2 of bovines, ovines, and caprines as well as a, b, c, and T of equines. They had a molecular mass of approximately 49,000 Da. Thus, the Fc receptors from L streptococci corresponded to type III Fc receptors of Streptococcus dysgalactiae.
authors: Institut für Bakteriologie und Immunologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
authors: C
authors: C
authors: Lämmler
authors: P
authors: P
authors: Schaufuss
authors: C
authors: C
authors: Frede
authors: H
authors: H
authors: Blobel
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D005340:Fibrinogen / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000378:metabolism*; D011961:Receptors, Fc / Q000302:isolation & purification / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013291:Streptococcus / Q000276:immunology / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D005353:Fibronectins; D007074:Immunoglobulin G; D011961:Receptors, Fc; D000511:alpha-Macroglobulins; D012710:Serum Albumin, Bovine; D005340:Fibrinogen