title: A light-induced decrease of cyclic GMP is involved in the photoresponse of molluscan extraocular photoreceptors.
abstract: The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the light-induced decrease of cGMP levels in A-P-1 may be responsible for the photoreceptor potential, like vertebrate phototransductions.
authors: Department of Physiology, School of Medicine, Kagoshima University, Japan.
authors: T
authors: T
authors: Nishi
authors: T
authors: T
authors: Gotow
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008029:Lighting; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca / Q000378:metabolism / Q000502:physiology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
chemical_list: D006152:Cyclic GMP; D015056:1-Methyl-3-isobutylxanthine