[Action of forskolin on the calcium current in the membrane of nerve cells in mollusks].
The action of forskolin, adenylate cyclase activator, on the calcium inward current was studied on intracellularly perfused nonidentified snail neurons. Extracellular application of 5-20 mumol/l of forskolin was shown to cause about 20% increase of the calcium current amplitude and this confirms the previous suggestion that the stimulation of the cellular synthesis of cAMP leads to enhancement of the calcium current through the cell membrane.
Doroshenko
P A
PA
Kostiuk
P G
PG
Luk'ianets
E A
EA
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005576:Colforsin / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D012908:Snails / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical
D007473:Ion Channels; D005576:Colforsin; D002118:Calcium
Deĭstvie forskolina na kal'tsievyĭ tok v membrane nervnykh kletok molliuska.