Intracellular phosphoribosyl diphosphate level and glucose carrier in Ehrlich ascites tumour cells during tumour growth and diabetes in tumour-bearing mice.
The ability of Ehrlich ascites tumour (EAT) cells in mice to take up glucose as well as the density of glucose carriers on the cells increased progressively during the course of tumour development. Simultaneously as the rate of uptake rose, the intracellular phosphoribosyl diphosphate (PRPP) levels dropped responding to the decrease of serum glucose. Hyperglycaemia induced in the host by alloxan or streptozotocin administration increased the serum glucose concentrations and intracellular PRPP levels but decreased the density of glucose carriers of the cells, whereas insulin administration reversed this condition. The physiological significance of these observations are discussed.
Choy
Y M
YM
Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T.
Lam
W P
WP
Fung
K P
KP
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000502:physiology; D007700:Kinetics; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D010428:Pentosephosphates / Q000378:metabolism*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D010428:Pentosephosphates; D010754:Phosphoribosyl Pyrophosphate