Cell adhesion molecules in neural development.
Adhesive mechanisms have been implicated in several morphogenetic processes during development. In the last decade several molecules mediating specific adhesion between cells and between cells and their environment have been characterized. Possible roles in morphogenesis have been established for some of these molecules. In the brain, four cell-cell adhesion molecules have been characterized: NCAM, L1, the myelin-associated glycoprotein and N-cadherin. Furthermore, a cell-substrate adhesion molecule, cytotactin, and its proteoglycan ligand have been described. We here review the data on structure, localization, developmental regulation and function of these molecules in brain.
Linnemann
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D
Research Center for Medical Biotechnology, University of Copenhagen, Denmark.
Bock
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E
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000196:embryology; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D006023:Glycoproteins / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D009185:Myelin Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein; D009420:Nervous System / Q000032:analysis* / Q000196:embryology / Q000254:growth & development; D009474:Neurons / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism; D019063:Tenascin
D000954:Antigens, Surface; D002135:Calcium-Binding Proteins; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D011509:Proteoglycans; D019063:Tenascin