[A study of the change in conductivity of the neuronal membrane caused by a generator potential using a method of computer modeling].
Injection of cAMP induces in snail neurons generator potential, which is related to an increase of sodium and decrease of potassium permeability of the neuron outer membrane. A model is proposed which takes into account cAMP diffusion inside the neuron from the injection place and interaction of these molecules with the intercellular system controlling permeability of the outer membrane. Resulting impulse generation induces calcium ions current through the outer membrane. The model also considers calcium diffusion toward cAMP and its effect on the rate of the enzyme work destroying cAMP. Agreement between the calculations of ionic current I(t) and the experiment permits determination of the model parameters and calculation of the observed change of time distribution of nerve impulses when calcium input is significant.
Liberman
E A
EA
Mamikonova
T A
TA
Minina
S V
SV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D003198:Computer Simulation; D000242:Cyclic AMP / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D008433:Mathematics; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D012908:Snails
D007473:Ion Channels; D000242:Cyclic AMP; D002118:Calcium
Izuchenie izmeneniia provodimosti membrany neĭrona, vyzyvaiushchego generatornyĭ potential, metodom modelirovaniia na EVM.