Variable-region sequence homologies of human kappa-chains with idiotypic serologic similarities.
An antibody to the V-region of a kappa I light chain has been used to detect other human kappa-chains with similar idiotypic specificities that appear to be related to complementarity-determining regions (CDR). Four such proteins, three of which react with this antibody, have been sequenced. While the proteins show relatively strong sequence similarities in their CDR2 regions, the relatively high degree of homology in a localized segment of the V-region of lambda-chains detected by this method was not observed here.
Kim
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HS
Department of Physiological Chemistry, University of Wisconsin-Madison 53706.
Deutsch
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HF
D000595:Amino Acid Sequence; D000939:Epitopes; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains