[Determination of specific IgG4 in allergy].
Measurement of the titre of specific IgG4 by the ELISA method may provide objective assistance to the control of specific immunotherapy (IS) to hymenoptera venom and grass pollens. A marked increase of the specific IgG4 titre in the first 3 months of IS or a titre already raised before the start of IS correlated with poor clinical results. Specific IgG4 can not be considered to be a diagnostic indicator in food allergy since we have frequently found this type of antibody in control subjects. Specific IgG4 in food allergy expresses a mucosal marker rather than a pathological reaction.
Sabbah
A
A
Laboratoires Pharmacia, Angers.
Lebricon
T
T
Penn
P
P
Vassal
V
V
Heulin
M G
MG
D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D002648:Child; D003888:Desensitization, Immunologic; D005260:Female; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007074:Immunoglobulin G / Q000032:analysis* / Q000096:biosynthesis; D007299:Insect Bites and Stings / Q000276:immunology / Q000628:therapy; D008297:Male; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy; D014862:Wasp Venoms / Q000276:immunology / Q000627:therapeutic use
D007074:Immunoglobulin G; D014862:Wasp Venoms
Intérêt du dosage des IgG4 spécifiques dans l'allergie.