[Inhibitory effect of pingyangmycin on human liver cancer and stomach cancer xenografts in nude mice].
Established human cancer cell lines derived from liver cancer (BEL-7402), nasopharyngeal cancer (CNE-2) and stomach cancer (MGC-803) were used in this study. These human cancer cells have been serially transplanted in nude mice. As determined by clonogenic assay, pingyangmycin (bleomycin A5) was highly cytotoxic to these three cell lines, of which the liver cancer cell line was more sensitive than the other two. At a tolerated dose level, pingyangmycin exhibited a remarkable growth inhibition on the growth of the liver cancer and stomach cancer xenografts, the inhibition rates being 70% and 85%, respectively. No pathologic changes were found in the organs of treated animals.
Jiang
M
M
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing.
D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology* / Q000031:analogs & derivatives; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002460:Cell Line; D005260:Female; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C021771:zhengguangmycin