Proximal motor neuropathy, IgA paraproteinaemia and anti-myelin-associated glycoprotein reactivity.
We report a case with proximal motor neuropathy associated with benign IgA lambda paraproteinaemia. Immunoblot demonstrated reactivity to myelin-associated glycoprotein and not to P2 protein of peripheral nerve. Dramatic improvement of the polyneuropathy was observed with steroid treatment alone within 4 weeks.
Hemachudha
T
T
Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
Phanuphak
P
P
Phanthumchinda
K
K
Kasempimolporn
S
S
D000368:Aged; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D009046:Motor Neurons; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D009468:Neuromuscular Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use
D007070:Immunoglobulin A; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D011239:Prednisolone