Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils.
Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.
Andersson
R G
RG
Department of Pharmacology, Faculty of Health Sciences, Linköping, Sweden.
Bartonek
M
M
Lindström
E
E
Lindström
I M
IM
Toll
J B
JB
D000888:Antibodies, Anti-Idiotypic; D001491:Basophils / Q000187:drug effects / Q000276:immunology*; D004075:Diglycerides / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E; D066298:In Vitro Techniques; D007700:Kinetics; D010741:Phospholipases A / Q000494:pharmacology; D054467:Phospholipases A2
D000888:Antibodies, Anti-Idiotypic; D004075:Diglycerides; D007073:Immunoglobulin E; D010741:Phospholipases A; D054467:Phospholipases A2; C013965:diolein