Squamous cell carcinoma of the skin with an unusual marker chromosome.
Chromosome studies were undertaken on uncultured material from a primary anaplastic squamous cell carcinoma of the skin from a female aged 81. The modal chromosome number was 42. Four marker chromosomes were present in most metaphases: a der (1) which resulted in tetrasomy for most of 1q, a giant chromosome consisting of most of a chromosome 2 and 4q, a small metacentric which was probably an isochromosome for 4p or 5p, and a small chromosome, considered to be an 18q+. The latter was conspicuous in unbanded orcein-stained preparations owing to the presence of a virtually nonstaining region on its long arm. These findings are of interest in the light of the paucity of data on this type of tumour.
Atkin
N B
NB
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, Great Britain.
Baker
M C
MC
Petković
I
I
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D005260:Female; D005546:Forehead; D005819:Genetic Markers / Q000032:analysis*; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology*; D013194:Staining and Labeling
D005819:Genetic Markers