The bactericidal activity of DR-3355, an optically active isomer of ofloxacin.
The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against Escherichia coli, Staphylococcus aureus and S. epidermidis, in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration at which maximum bacterial kill was achieved. Hence it appears that DR-3355 is twice as active as ofloxacin not only in terms of its ability to inhibit bacterial multiplication but also in its ability to kill bacteria. DR-3355 was found to be active against non-dividing bacteria and did not require either active RNA or protein biosynthesis in order to kill bacteria.
Lewin
C S
CS
Department of Bacteriology, Medical School, University of Edinburgh.
Amyes
S G
SG
D001426:Bacterial Proteins / Q000096:biosynthesis; D002701:Chloramphenicol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development
D001426:Bacterial Proteins; D012329:RNA, Bacterial; D002701:Chloramphenicol; D015242:Ofloxacin