The evaluation of possible melanoma risk groups of patients in a series of pigmented naevi. Clinical and histological intercorrelations.
The trends of the clinical/histological intercorrelations in two series of pigmented naevi have been compared. One series of naevi represents patients who are habitual sunbathers and/or who have travelled to Southern sunny climates. The other series includes naevi from easily sunburned patients. The sunburner-group is correlated to histological features such as mitoses, atypia and fibrosis of the tumour as well as to an irregular/atypical tumour type. Such trends are not found in the other target group. The sunburners have a poor ability to suntan, while the sunbather group includes good suntanners. This indicates the importance of the melanin UV-filter effect of the skin as a protection against the promotion of potential MM-precursors, such as irregular/atypical naevi.
Larsen
T E
TE
Department of Pathology, Ullevaal Hospital, Oslo, Norway.
Mogensen
S B
SB
Holme
I
I
D006801:Humans; D008545:Melanoma / Q000175:diagnosis*; D009508:Nevus, Pigmented / Q000473:pathology*; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D013471:Sunburn / Q000473:pathology / Q000517:prevention & control; D013473:Sunscreening Agents
D013473:Sunscreening Agents