Inhibition of radiation induced changes in testicular RNA content by a thiophosphate.
Radiation induced changes in the testicular RNA content of whole body irradiated Swiss albino mouse and their modification by a thiophosphate, WR-2721 were studied. Three different doses of gamma radiation were given for the purpose. The RNA content of the testis was found to be affected adversely after irradiation. It was observed that the drug inhibited the alterations in the RNA content to a significant extent. Degree of protection and possible mechanisms of action have been discussed.
Jaimala
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D012313:RNA / Q000378:metabolism*; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D009946:Organothiophosphorus Compounds; D012313:RNA; D004999:Amifostine