Midlatency auditory evoked responses: differential abnormality of P1 in Alzheimer's disease.
The human 'P1' middle latency evoked potential is postulated to be generated in the thalamus by a cholinergic component of the ascending reticular activating system. To test the hypothesis that P1 and its generator substrate are abnormal in Alzheimer's disease (AD), a disorder of marked cholinergic deficiency, recordings of middle latency responses to click stimuli were carried out. Comparisons between the AD and age-matched control groups indicated normal auditory brain-stem and Pa responses but a significant decrease in P1 amplitude. This P1 abnormality suggests that the midbrain cholinergic cells in AD may be dysfunctional.
Buchwald
J S
JS
Department of Physiology, UCLA Medical Center.
Erwin
R J
RJ
Read
S
S
Van Lancker
D
D
Cummings
J L
JL
D000328:Adult; D000544:Alzheimer Disease / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012016:Reference Values