[Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II].
Inhibitory effect of 3'-azide-3'deoxy-ribavirin-5'-triphosphate on activity of RNA-dependent RNA polymerase from influenza A virus as well as on DNA-dependent RNA polymerase II from mice liver nuclei was studied. The drug inhibited effectively RNA synthesis catalyzed by these enzymes, whereas its most selective inhibitory action was found in reaction with RNA polymerase from influenza A virus.
Pravdina
N F
NF
Galegov
G A
GA
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D002384:Catalysis; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D009980:Influenza A virus / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D009711:Nucleotides / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors*; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
D001386:Azides; D009711:Nucleotides; D012263:Ribonucleosides; C060210:3'-azido-3'-deoxyribavirin-5'-triphosphate; D012254:Ribavirin; D012313:RNA; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases
Ingibiruiushchee deĭstvie 3'-azido-3'-dezoksiribavirin-5'- trifosfata na sintez RNK, kataliziruemyĭ RNK-polimerazoĭ virusa grippa A i kletochnoĭ DNK-zavisimoĭ RNK-polimerazoĭ II.