BAY K 8644 enhances immobility in the mouse behavioral despair test, an effect blocked by nifedipine.
The effect of the dihydropyridine calcium channel agonist, BAY K 8644 (0.05, 0.1, 0.5 mg/kg i.p.), in the mouse behavioral despair test was investigated. BAY K 8644 dose dependently prolonged the duration of immobility. The BAY K 8644 (0.1 mg/kg)-induced prolongation of immobility was antagonized by the dihydropyridine calcium channel antagonist, nifedipine, but not by the non-dihydropyridine type antagonists, verapamil and diltiazem. The effect of BAY K 8644 was also antagonized by desipramine and imipramine but not by citalopram and iprindole. Therefore we suggest that central dihydropyridine binding sites play a role in despair behavior.
Mogilnicka
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E
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Czyrak
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A
Maj
J
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D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels; D003863:Depression / Q000139:chemically induced* / Q000188:drug therapy; D007103:Immobilization; D008297:Male; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology
D000928:Antidepressive Agents; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D011978:Receptors, Nicotinic; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009543:Nifedipine