title: Immunoreactive human chorionic gonadotrophin from the cyst fluid and CSF of patients with craniopharyngioma.
abstract: A specific radioimmunoassay for the beta-chain of human chorionic gonadotrophin irHCG beta has demonstrated HCG-like material to be present in craniopharyngioma cyst fluid in nine consecutive patients with craniopharyngioma. There was no detectable LH/HCG bioactivity as assessed using testosterone production from isolated Leydig cells from rat testis in seven samples tested. One patient was also found to have measurable irHCG beta in the cerebrospinal fluid (CSF), which fell to undetectable levels following surgery; in this patient, there was clinical evidence that the cyst fluid had leaked into the CSF pre-operatively. Immunocytochemical staining for HCG beta and intact HCG was positive in five of the tumours. irHCG beta was not measurable in the serum of any of the patients.
authors: Department of Endocrinology, St Bartholomew's Hospital, London, UK.
authors: P E
authors: PE
authors: Harris
authors: L
authors: L
authors: Perry
authors: T
authors: T
authors: Chard
authors: L
authors: L
authors: Chaudry
authors: B A
authors: BA
authors: Cooke
authors: R
authors: R
authors: Touzel
authors: P
authors: P
authors: Coates
authors: D G
authors: DG
authors: Lowe
authors: F
authors: F
authors: Afshar
authors: J A
authors: JA
authors: Wass
mesh_terms: D001681:Biological Assay; D006063:Chorionic Gonadotropin / Q000032:analysis* / Q000134:cerebrospinal fluid; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003397:Craniopharyngioma / Q000032:analysis* / Q000134:cerebrospinal fluid; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis / Q000134:cerebrospinal fluid; D010911:Pituitary Neoplasms / Q000032:analysis* / Q000134:cerebrospinal fluid; D011863:Radioimmunoassay
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments