Clinical study of asthma in adolescents and in young adults. Correlation between laboratory findings and severity of asthma.
Fifty-eight mite-allergic asthmatic patients ages 15 to 22 years were examined. Low respiratory threshold to acetyl-choline (RT-Ach), high maximal histamine release (HR) by mite and anti-IgE, high serum IgE levels and high eosinophil counts were highly associated with the severity of asthma. RT-Ach correlated inversely with HR to mite and anti-IgE. The maximal histamine release from leukocyte caused by anti-IgE also correlated highly with the severity of asthma.
Juji
F
F
Department of Pediatrics, Faculty of Medicine, University of Tokyo, Japan.
Takashima
H
H
Takaishi
T
T
Morita
Y
Y
Ito
K
K
Miyamoto
T
T
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D000918:Antibody Specificity; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D004804:Eosinophils; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology / Q000494:pharmacology; D007958:Leukocyte Count; D008297:Male; D009299:Nasal Provocation Tests; D012130:Respiratory Hypersensitivity / Q000503:physiopathology
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies; D007073:Immunoglobulin E