Electron microscopy of tubuloreticular structures in allergic patch test. Observations with 2,3-epoxypropyl trimethyl ammonium chloride.
Tubuloreticular structures (TRS) are intracellular tubular inclusions that can be detected by means of electron microscopy. TRS have earlier been found in autoimmune, viral and neoplastic diseases. Here the occurrence of TRS is for the first time described in allergic patch tests, where they were detected in dermal macrophages. TRS are believed to be reaction products of metabolically active cells, and the TRS described here are probably formed as a result of the activation of the immune system in allergic patch tests.
Kanerva
L
L
Section of Dermatology, Institute of Occupational Health, Helsinki, Finland.
D003877:Dermatitis, Contact / Q000209:etiology / Q000473:pathology*; D004852:Epoxy Compounds / Q000009:adverse effects*; D004988:Ethers, Cyclic / Q000009:adverse effects*; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008264:Macrophages / Q000473:pathology / Q000648:ultrastructure; D010328:Patch Tests; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D012867:Skin / Q000473:pathology / Q000648:ultrastructure
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D000644:Quaternary Ammonium Compounds; C045006:glycidyl trimethylammonium