Mitochondrial genome in animal cells. Structure, organization, and evolution.
In the past decade, the development of new DNA, RNA, and protein technologies has greatly incremented the knowledge about the organization and expression of mitochondrial DNA. The complete base sequence of mitochondrial DNA of several animals is known and many data are rapidly accumulating on the mitochondrial genomes of other systems. Here we discuss the results so far obtained that disclosed unexpected features of mitochondrial genetics. Furthermore, mitochondrial DNA has become established as a powerful tool for evolutionary studies in animals. Evidences are presented demonstrating that the evolution of mitochondrial DNA has proceeded in different ways in the various taxonomic groups. Data on heteroplasmic animals, which demonstrate the rapid evolution of mitochondrial DNA, are also presented.
De Giorgi
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Dipartimento di Biochimica e Biologia Molecolare, University of Bari, Italy.
Saccone
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D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics / Q000502:physiology / Q000648:ultrastructure*; D005838:Genotype; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
D004272:DNA, Mitochondrial