Antigenuria in chronic chagasic patients detected by a monoclonal antibody raised against Trypanosoma cruzi.
A monoclonal antibody (B2/5) raised against Trypanosoma cruzi was able to immunoprecipitate a major 100 kDa polypeptide in 84% of the urines collected from chronic chagasic patients. Other polypeptides were also detected. The antibody recognized polypeptides on the surface of epimastigotes (150-25 kDa) and metacyclic trypomastigotes (150-50 kDa), suggesting that the antigens share a common epitope.
Katzin
A
A
Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Alves
M J
MJ
Abuin
G
G
Colli
W
W
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan / Q000276:immunology / Q000652:urine*; D000954:Antigens, Surface / Q000276:immunology / Q000652:urine; D014355:Chagas Disease / Q000276:immunology* / Q000652:urine; D002908:Chronic Disease; D000939:Epitopes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014349:Trypanosoma cruzi / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D000939:Epitopes