Ion channels and G proteins.
Newly discovered relationships offer insight into the mechanisms by which extracellular signals produce complex cellular responses. Ion channels, serving crucial cellular functions, are now known to be gated by G proteins directly (by membrane-delimited processes) and indirectly (by cytoplasmic second messengers). It also appears that a G protein may act on several effectors.
Brown
A M
AM
Baylor College of Medicine, Houston.
Birnbaumer
L
L
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D016275:Atrial Function; D015220:Calcium Channels / Q000502:physiology; D002450:Cell Communication; D002462:Cell Membrane / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008024:Ligands; D015221:Potassium Channels / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology; D015398:Signal Transduction; D016276:Ventricular Function
D015220:Calcium Channels; D007473:Ion Channels; D008024:Ligands; D015221:Potassium Channels; D011950:Receptors, Cholinergic; D019204:GTP-Binding Proteins; D000109:Acetylcholine