title: Lymphocytosis of large granular lymphocytes in three dogs.
abstract: The clinical course and hematologic changes of three dogs with lymphocytosis of cells morphologically resembling large granular lymphocytes are presented. Hemograms from all dogs showed leukocytosis with marked lymphocytosis. Lymphocytes were characterized by abundant basophilic cytoplasm containing distinct granules which varied in size and number. Electron microscopically the granules were membrane-bound with an electron-dense core. Lymphocytes from one dog were positive for alkaline phosphatase activity, and lymphocytes from another dog were positive for alpha naphthyl butyrate esterase activity. Lymphocytes from one dog were positive for surface receptors for the crystalline fraction portion of gamma immunoglobulins.
authors: Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus.
authors: M L
authors: ML
authors: Wellman
authors: C G
authors: CG
authors: Couto
authors: R J
authors: RJ
authors: Starkey
authors: J L
authors: JL
authors: Rojko
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008214:Lymphocytes / Q000648:ultrastructure*; D008218:Lymphocytosis / Q000473:pathology / Q000662:veterinary*; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron; D013194:Staining and Labeling