title: Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum.
abstract: We have observed that iloprost, a prostacyclin analog, causes the translocation of a 23-kDa protein from the membrane to the cytosol of human platelets. This 23-kDa protein is recognized by a Gs alpha (alpha subunit of stimulatory guanine nucleotide binding regulatory protein) antiserum but is not ADP-ribosylated by cholera toxin. The translocation of the Gs alpha-related protein might be an important part of the complex chain of events resulting in agonist-induced desensitization.
authors: Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709.
authors: L
authors: L
authors: Molina Y Vedia
authors: E G
authors: EG
authors: Lapetina
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D002317:Cardiovascular Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D011464:Epoprostenol / Q000494:pharmacology*; D019204:GTP-Binding Proteins / Q000097:blood* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D016285:Iloprost; D007106:Immune Sera; D046911:Macromolecular Substances; D008970:Molecular Weight
chemical_list: D002317:Cardiovascular Agents; D007106:Immune Sera; D046911:Macromolecular Substances; D011464:Epoprostenol; D019204:GTP-Binding Proteins; D016285:Iloprost