The association of Campylobacter pylori with mucosal pathological changes in a population at risk for gastric cancer.
In the study of a group of 178 unselected patients (105 men, 73 women, mean age 44.5 years), from a population at high risk for gastric carcinoma, who presented with chronic dyspepsia, a minimum of 8 gastric and oesophageal biopsy specimens were taken during upper gastro-intestinal endoscopy, and examined histologically and histochemically for the presence of Campylobacter pylori and other pathological lesions. Gastric colonisation by C. pylori was found in 75% of men and 68.4% of women. In 90% of patients with duodenal or gastric ulcer and in 71.6% of patients with non-ulcer and non-cancer dyspepsia there was a moderate or severe degree of bacterial colonisation. Association between C. pylori colonisation and microscopic evidence of type B gastritis, gastric or duodenal ulcer, gastric cancer, oesophagitis and oesophageal glycogenic acanthosis was found.
Jaskiewicz
K
K
Department of Pathology, University of Cape Town.
Louwrens
H D
HD
Woodroof
C W
CW
van Wyk
M J
MJ
Price
S K
SK
D000328:Adult; D000368:Aged; D001706:Biopsy; D002167:Campylobacter / Q000302:isolation & purification*; D004415:Dyspepsia / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology; D005756:Gastritis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000209:etiology*