title: Inhibition of aspartic proteinases by alpha 2-macroglobulin.
abstract: The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.
authors: Department of Biochemistry, University of Wales College of Cardiff, U.K.
authors: D J
authors: DJ
authors: Thomas
authors: A D
authors: AD
authors: Richards
authors: J
authors: J
authors: Kay
mesh_terms: D002402:Cathepsin D / Q000037:antagonists & inhibitors*; D020059:Cathepsin E; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D012085:Chymosin / Q000037:antagonists & inhibitors*; D006863:Hydrogen-Ion Concentration; D000511:alpha-Macroglobulins / Q000494:pharmacology*
chemical_list: D000511:alpha-Macroglobulins; D002403:Cathepsins; D020059:Cathepsin E; D012085:Chymosin; D002402:Cathepsin D