Post-transcriptional control of negative acute phase genes by transforming growth factor beta.
During the acute phase (AP) reaction the expression of a series of liver-specific genes coding for secretory proteins is either stimulated or suppressed by different cytokines released by activated monocytes. Transforming growth factor beta (TGF-beta) is a cytokine that, first identified for its ability to regulate cellular growth, has been gradually recognized to modulate several other functions. We have investigated the effect of TGF-beta on the expression of acute phase genes in liver cells. We found that TGF-beta selectively induces a specific decreases in the amount of mRNAs of genes negatively regulated during AP reaction, like albumin and apolipoprotein A-I (ApoA-I). The inhibitory effect of TGF-beta on the expression of negative AP genes is primarily post-transcriptional and it is very likely to be mediated via an enhancement of the turnover of both albumin and ApoA-I mRNAs.
Morrone
G
G
European Molecular Biology Laboratory, Heidelberg, FRG.
Cortese
R
R
Sorrentino
V
V
D000209:Acute-Phase Proteins / Q000235:genetics*; D000418:Albumins / Q000235:genetics; D001054:Apolipoproteins A / Q000235:genetics; D002460:Cell Line; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D014158:Transcription, Genetic; D015291:Transforming Growth Factors / Q000502:physiology*
D000209:Acute-Phase Proteins; D000418:Albumins; D001054:Apolipoproteins A; D012333:RNA, Messenger; D015291:Transforming Growth Factors