Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.
The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.
Isogai
H
H
Isogai
E
E
Fujii
N
N
Oguma
K
K
Chang
K L
KL
Deguchi
E
E
Takano
K
K
Hayashi
M
M
Namioka
S
S
D000421:Alcaligenes / Q000032:analysis*; D000818:Animals; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000032:analysis; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008163:Luminescent Measurements; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D007375:Interleukin-1; D007376:Interleukin-2; D008070:Lipopolysaccharides; D007372:Interferons