Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation.
Granulocyte colony-stimulating factor (G-CSF) was administered by continuous subcutaneous infusion to 15 patients with non-myeloid malignancies treated by high-dose chemotherapy and autologous bone marrow infusion. G-CSF was given at variable dosage based on neutrophil count. Sustained serum levels of G-CSF were achieved. Neutrophil recovery was accelerated in G-CSF treated patients compared with 18 historical controls and exceeded 0.5 x 10(9)/l at a mean of 11 days after marrow infusion compared with 20 days for controls, a significant difference. This reduction led to significantly fewer days of parenteral antibiotic therapy, 11 versus 18 days in controls, and less isolation in reverse-barrier nursing, 10 versus 18 days.
Sheridan
W P
WP
Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Victoria.
Morstyn
G
G
Wolf
M
M
Dodds
A
A
Lusk
J
J
Maher
D
D
Layton
J E
JE
Green
M D
MD
Souza
L
L
Fox
R M
RM
D000380:Agranulocytosis; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation / Q000379:methods*; D002066:Busulfan / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003115:Colony-Stimulating Factors / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D016179:Granulocyte Colony-Stimulating Factor; D006689:Hodgkin Disease / Q000097:blood / Q000628:therapy*; D006801:Humans; D007260:Infusion Pumps; D007263:Infusions, Parenteral; D007958:Leukocyte Count / Q000187:drug effects; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000628:therapy*; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000493:pharmacokinetics; D013997:Time Factors
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide; D002066:Busulfan