The influence of factor XIII on the fibrosing of a nerve anastomosis in the rat.
Although the fibrin adhesion enjoys increasing success in many areas of surgery, it has not become fully established in nerve anastomosis. It was in this area particularly that significant advantages were expected. As the fibrin clot dissolved prematurely, however, and dehiscences ensued, antifibrinolytic substances had to be added to the adhesive. Fibroses occurred frequently as a result, which to date encumber nerve adhesive. We examined Faktor XIII for his fibrosis-inducing effect because both presently available fibrin adhesives contain unphysiologically high concentrations of it. We were able to establish that Factor XIII possesses a fibrosis-promoting effect.
Herter
T
T
Klinik und Poliklinik für Neurochirurgie Westfälischen Wilhelms-Universität, Münster, Federal Republic of Germany.
Anaguostopoulos-Schleep
J
J
Windmann
D
D
D000714:Anastomosis, Surgical; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005176:Factor XIII / Q000494:pharmacology*; D005339:Fibrin Foam / Q000494:pharmacology; D005355:Fibrosis; D009420:Nervous System / Q000473:pathology*; D019635:Neurosurgical Procedures; D051381:Rats; D011919:Rats, Inbred Strains
D005339:Fibrin Foam; D003094:Collagen; D005176:Factor XIII