The immune response of carp against dextran. An analysis of the idiotype heterogeneity.
The expression of a "species-specific" idiotype with specificity for alpha(1-6) dextran in carp is described. All tested carp anti-dextran antisera react with a rabbit anti-Id (carp anti-dex) serum. The rabbit anti-Id serum can be partially inhibited by the specific ligand, dextran T70 or isomaltodecaose but not or only weak with other, unrelated carbohydrates. These data confirm our statement, that a limited germline V-gene repertoire may code for antibodies in fish.
Richter
R F
RF
Section of Biosciences, Karl-Marx-Universität, Leipzig, GDR.
Ambrosius
H
H
D000818:Animals; D000918:Antibody Specificity; D002347:Carps / Q000276:immunology*; D003530:Cyprinidae / Q000276:immunology*; D003911:Dextrans / Q000276:immunology*; D005803:Genes, Immunoglobulin; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007135:Immunoglobulin Variable Region / Q000235:genetics; D009154:Mutation; D011817:Rabbits
D003911:Dextrans; D007130:Immunoglobulin Idiotypes; D007135:Immunoglobulin Variable Region