[Toxicity of para-aminobenzhydrazide and its influence on nucleic acid biosynthesis in cultures of normal and tumor cells].
We have investigated cytotoxic action of p-aminobenzhydrazide and its influence on biosynthesis of nucleic acids in cultures of intact cells, tumor cells and intact cells stimulated by phytohemagglutinin. p-Aminobenzhydrazide is considered as a representative of hydrazine's derivatives (in particular, of hydrazine sulphate). We compare its action with that of a typical cytotoxic agent such as iododeoxyuridine. We have found that p-aminobenzhydrazide influences biosynthesis of nucleic acids in the same way as iododeoxyuridine. However it acts toxically on tumor cells though it is not toxic for intact cells so that its action is different as compared to that of cytotoxic agents. Specific toxic action of aminobenzhydrazide on tumor cells may be due to the enhancement of antitumor activity substances of this compound and absence of such enhancement of side toxic effects.
Tret'iakov
A V
AV
Onishchuk
F D
FD
Filov
V A
VA
D000814:Aniline Compounds / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology / Q000633:toxicity; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D010215:Papio; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects*; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014498:Uracil / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity
D000814:Aniline Compounds; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; C034343:4-aminobenzhydrazide; D014498:Uracil; C008378:6-methyluracil; D012313:RNA; D004247:DNA; D007065:Idoxuridine
Toksichnost' para-aminobenzgidrazida i ego vliianie na biosintez nukleinovykh kislot v kul'turakh normal'nykh i opukholevykh kletok.