Histamine releasing action of calcium ionophore 985-I.
The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10-50 microM) of the ionophore was a selective (noncytotoxic) process. It was energy and Ca2+-dependent and was potentiated by glucose. In this respect the mode of action of 985-I was similar to that of the Ca2+-ionophore A23187. On the other hand some pharmacological agents (phencarol, verapamil and amitriptyline) inhibited histamine secretion induced by 985-I but not A23187-induced histamine release. These data point to some differences between the mechanisms of action of 985-I and A23187.
Gushchin
I S
IS
Laboratory of Cytology, Institute of Immunology, Moscow, USSR.
Zebrev
A I
AI
Voitenko
V G
VG
D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000276:immunology; D000001:Calcimycin / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D011919:Rats, Inbred Strains
D004987:Ethers; D007476:Ionophores; C056472:omomycin; D000001:Calcimycin