Immunohistochemical staining for vimentin filaments and S-100 protein in myxoma of the jaws.
Two jaw myxomas have been analyzed by a panel of antibodies to characterize this tumour type. Vimentin, but not keratin, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), neurofilament (NF), desmin and Factor VIII-related antigen (FVIII-AG), demonstrated positivity in the cytoplasm of the neoplastic cells. Moreover, an antibody against S-100 protein also showed a strong positive reaction in the cytoplasm of the tumour cells examined. Thus directly indicating a mesenchymal derivation for odontogenic myxoma, and is the first demonstration of S-100 protein within the cells of this tumour type.
Lombardi
T
T
Division of Stomatology and Oral Surgery, Faculty of Medicine of Geneva, Switzerland.
Kuffer
R
R
Bernard
J P
JP
Fiore-Donno
G
G
Samson
J
J
D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure; D003599:Cytoskeleton / Q000032:analysis*; D005109:Extracellular Matrix / Q000648:ultrastructure; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000032:analysis*; D008339:Mandibular Neoplasms / Q000032:analysis* / Q000648:ultrastructure; D009232:Myxoma / Q000032:analysis* / Q000648:ultrastructure; D009363:Neoplasm Proteins / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*; D013194:Staining and Labeling; D014746:Vimentin / Q000032:analysis*
D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin