Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?
Lifetime probability density functions from single-channel recording are usually assumed to follow a multiexponential form. The amplitudes and rate constants for each exponential component are presumed to be independent. We have explored this assumption and have found a correlation between the amplitudes and the rate constants in certain cases. We examine this correlation and the possibility that other functional forms may also properly describe these distribution functions.
Millhauser
G L
GL
Department of Pharmacology, New York State College of Veterinary Medicine Cornell University, Ithaca 14853.
Salpeter
E E
EE
Oswald
R E
RE
D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008962:Models, Theoretical
D007473:Ion Channels