Simultaneous assay for urinary 4-hydroxy-3-methoxy-mandelic acid, 5-hydroxyindoleacetic acid and homovanillic acid by isocratic HPLC with electrochemical detection.
A method is described for the simultaneous determination of urinary HMMA, 5-HIAA and HVA by HPLC with electrochemical detection. The method was evaluated over an 8-month period and has thus far identified 2 cases of phaeochromocytoma, 1 case of neuroblastoma and 2 of carcinoid tumour.
Davidson
D F
DF
Biochemistry Department, Crosshouse Hospital, Scotland, UK.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002138:Calibration; D002151:Calorimetry; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D005069:Evaluation Studies as Topic; D005260:Female; D015200:Fluoroimmunoassay; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014642:Vanilmandelic Acid / Q000652:urine*
D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D006719:Homovanillic Acid