title: B-cell reconstitution after autologous bone marrow transplantation: increase in serum CD23 ("IgE-binding factor") precedes IgE and B-cell regeneration.
abstract: The serum levels of IgE and the soluble cleavage product of CD23 (sCD23) were prospectively monitored for up to 1 year after transplantation in 34 patients who underwent autologous (n = 33) or syngeneic (n = 1) bone marrow transplantation (BMT). In 25 patients (74%), a transient IgE peak (two- to 2,750-fold increase) appeared in the serum 3 to 4 weeks after BMT. In 18 patients (51%), a two- to 125-fold increase in sCD23 coincided with the IgE peak. In only three patients was a sCD23 peak observed without a concomitant increase in IgE. The sCD23 increment preceded the IgE peak in each individual case. During the period of increased sCD23 serum levels, the absolute numbers of circulating B cells and other cell types expressing surface CD23 were extremely low. The biologic significance of these findings is discussed in light of present knowledge of regulation of B-cell growth and differentiation with special reference to the role of sCD23 as a multifunctional cytokine.
authors: Department of Clinical Immunology, University Hospital, Uppsala, Sweden.
authors: M
authors: M
authors: Bengtsson
authors: J
authors: J
authors: Gordon
authors: L
authors: L
authors: Flores-Romo
authors: J A
authors: JA
authors: Cairns
authors: B
authors: B
authors: Smedmyr
authors: G
authors: G
authors: Oberg
authors: B
authors: B
authors: Simonsson
authors: T H
authors: TH
authors: Tötterman
mesh_terms: D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D001402:B-Lymphocytes / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000032:analysis; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000032:analysis*; D011300:Preoperative Care; D011446:Prospective Studies; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000032:analysis*; D017455:Receptors, IgE; D014182:Transplantation, Autologous
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D000939:Epitopes; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017455:Receptors, IgE; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E