[Pharmacological investigations on the adrenalin-thrombin-induced platelet aggregation in dogs].
Adrenaline alone did not induce aggregation of canine blood platelets in citrated plasma in vitro; however, it potentiated the aggregation caused by thrombin concentrations which are too low to induce coagulation. Simultaneous infusion of adrenaline and thrombin resulted in accumulation of 111In-labelled platelets in the lung and in the heart as measured by means of a gamma camera. Separately infused adrenaline or thrombin did not change the distribution of radioactivity. In vitro and in vivo hirudin and cyproheptadine inhibited the adrenaline-thrombin-induced platelet aggregation. Dihydroergotamine exerted no in vivo effect at the doses used.
Nowak
G
G
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
Glusa
E
E
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004087:Dihydroergotamine / Q000494:pharmacology; D004285:Dogs; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D006629:Hirudins / Q000494:pharmacology; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D013917:Thrombin / Q000494:pharmacology*
D006629:Hirudins; D003533:Cyproheptadine; D004087:Dihydroergotamine; D013917:Thrombin; D004837:Epinephrine
Pharmakologische Untersuchungen zur Adrenalin-Thrombininduzierten Plättchenaggregation bei Hunden.