title: Role of intravenous isoproterenol in the electrophysiologic induction of atrioventricular node reentrant tachycardia in patients with dual atrioventricular node pathways.
abstract: To assess the role of intravenous isoproterenol for the facilitation of electrophysiologic induction of atrioventricular (AV) node reentrant tachycardia, 20 patients with dual AV node pathways who lacked inducible AV node reentrant tachycardia at control study had a constant isoproterenol infusion administered and underwent repeat study. Six (30%) of 20 patients (group I) had inducible AV node reentrant tachycardia during isoproterenol infusion whereas the other 14 (70%) patients (group II) did not. Paroxysmal supraventricular tachycardia was clinically documented in all 6 group I patients compared to 3 (21%) of 14 group II patients (p = 0.002). The sensitivity and specificity of isoproterenol-facilitated induction of AV node reentrant tachycardia were 67 and 100%, respectively. The isoproterenol-facilitated induction of sustained AV node reentry was mediated by resolution of the weak link in anterograde slow pathway in 2 (33%) patients, in retrograde fast pathway in 3 (50%) and in both anterograde slow and retrograde fast pathways in 1 (17%) patient. Four group I patients were given intravenous propranolol, 0.2 mg/kg body weight, and had complete suppression of isoproterenol-facilitated induction of AV node reentry. Thus, intravenous isoproterenol is a rather sensitive and highly specific adjunct to electrophysiologic induction of AV node reentrant tachycardia in patients with dual AV node pathways but without inducible sustained AV node reentry.
authors: Department of Medicine, Letterman Army Medical Center, San Francisco, California.
authors: E C
authors: EC
authors: Huycke
authors: W T
authors: WT
authors: Lai
authors: N X
authors: NX
authors: Nguyen
authors: E C
authors: EC
authors: Keung
authors: R J
authors: RJ
authors: Sung
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D006329:Heart Conduction System; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000139:chemically induced* / Q000503:physiopathology; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced / Q000503:physiopathology; D013616:Tachycardia, Sinus / Q000139:chemically induced / Q000503:physiopathology; D013617:Tachycardia, Supraventricular / Q000139:chemically induced*
chemical_list: D000319:Adrenergic beta-Antagonists; D007545:Isoproterenol