title: [Changes in the ultrastructure of rat hepatocyte nucleoli during bilateral adrenalectomy and after administration of cortisol].
abstract: Nucleolar ultrastructure of the rat hepatocytes after bilateral adrenalectomy and cortisol stimulation has been studied by the electron-microscopic method Traits of nucleolar inactivation (a decrease of granular component enlargement of fibrillar centres, condensation of peri- and intranucleolar chromatin, etc.) are observed in hepatocyte nucleoli 5 days after adrenalectomy. Cortisol stimulation of hepatocytes of the adrenalectomized rats leads to nucleolar activation (4h, 5h, 8h after the hormone injection). Adrenalectomy with following cortisol injection is a useful model to study inactivation and activation of ribosomal genes in the target cells.
authors: T V
authors: TV
authors: Mdivani
authors: A G
authors: AG
authors: Agladze
authors: G D
authors: GD
authors: Tumanishvili
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism / Q000648:ultrastructure*; D002843:Chromatin / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure*; D012313:RNA / Q000096:biosynthesis; D051381:Rats
chemical_list: D002843:Chromatin; D012313:RNA; D006854:Hydrocortisone
vernacular_title: Izmeneniia ul'trastruktury iadryshek gepatotsitov krys pri dvustoronneĭ adrenaléktomii i posle vvedeniia kortizola.