Is Ca2+ -activated potassium efflux involved in the formation of ischemic brain edema?
A possible role of Ca2+ -activated potassium efflux in brain ischemia was studied using a rat focal cortical infarction model. Three days after ischemic insult, tissue contents of water, sodium, potassium and calcium ions were measured. Charybdotoxin, a specific inhibitor of Ca2+ -activated potassium efflux, was found to reduce the formation of ischemic brain edema when a dosage of 0.15 mg/kg was given by i.v. 20-30 min prior to the onset of ischemic insult.
Tominaga
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Membrane Research Institute, University City Science Center, Philadelphia, PA 19104.
Katagi
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Ohnishi
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D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000502:physiology*; D002544:Cerebral Infarction / Q000503:physiopathology; D018999:Charybdotoxin; D007839:Functional Laterality; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012604:Scorpion Venoms / Q000494:pharmacology
D012604:Scorpion Venoms; D018999:Charybdotoxin; D011188:Potassium; D002118:Calcium