Neurologic sequelae following interferon therapy of juvenile laryngeal papilloma.
Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2-year-old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found.
Vesikari
T
T
Department of Paediatrics, Tampere University Central Hospital, Finland.
Nuutila
A
A
Cantell
K
K
D002547:Cerebral Palsy / Q000209:etiology*; D002675:Child, Preschool; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000009:adverse effects*; D007822:Laryngeal Neoplasms / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010212:Papilloma / Q000628:therapy*
D007372:Interferons