[The nature of serum factor precipitating autologous alpha-globulins in rabbits].
The nature of serum factor, resulted from the immune response to human albumin being a precipitant of auto-alpha-globulins in rabbits, have been studied. The use of ion exchange, immunoaffinity chromatography and immunoelectrophoresis has shown, that antibodies to human albumin, carrying the binding site to alpha-globulin in antigen-binding fragment are the factor responsible for alpha-globulin precipitation. The synthesis of antibodies cross-reacting to alpha-globulin gives the evidence of the selective derangement of tolerance to one of organism self antigens during the immune response to heterologous antigen.
Krutitskaia
L I
LI
Polosatov
M V
MV
D000510:Alpha-Globulins / Q000276:immunology*; D000818:Animals; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D007114:Immunization; D011234:Precipitins / Q000276:immunology*; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology
D000510:Alpha-Globulins; D007106:Immune Sera; D011234:Precipitins; D012709:Serum Albumin
Priroda syvorotochnogo faktora, pretsipitiruiushchego autologichnye al'fa-globuliny u krolikov.