Ewing's sarcoma with epithelial differentiation: fine structural and immunocytochemical study.
A femoral Ewing's sarcoma from a 13 1/2-year-old girl with otherwise typical clinical and pathological features showed epithelial differentiation by electron microscopy and immunocytochemistry. The expression of keratin and the presence of tonofilaments in cells of this Ewing's sarcoma may enforce the hypothesis that Ewing's sarcoma derives from a multipotential primitive stem cell.
Greco
M A
MA
Department of Pathology, NYU Medical Center, New York 10016.
Steiner
G C
GC
Fazzini
E
E
D000293:Adolescent; D001859:Bone Neoplasms / Q000378:metabolism / Q000648:ultrastructure; D002454:Cell Differentiation; D004847:Epithelial Cells; D005260:Female; D005269:Femur / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000648:ultrastructure; D007633:Keratins / Q000276:immunology; D008854:Microscopy, Electron; D009362:Neoplasm Metastasis; D012512:Sarcoma, Ewing / Q000378:metabolism / Q000648:ultrastructure
D007633:Keratins