[Changes in serum levels of glycoprotein hormone alpha subunits in patients with alphoma-type pituitary tumors during LHRH and TRH stimulation tests].
A group of 21 patients with the alphoma-type pituitary tumors was studied. In 9 cases the tumor was associated with acromegaly. Alpha subunit concentration was determined in all the patients and in control subjects in the course of dynamic tests consisting in simultaneous intravenous administration of 200 micrograms TRH and 100 micrograms LH-RH. In basal conditions the concentration of alpha subunit in patients with the alphoma-type tumors ranged between 2.1 and 30 micrograms/l (mean 7.5 +/- 6.6 micrograms/l), and in controls the respective values ranged between 0.2 and 1.6 micrograms/l (mean 0.78 +/- 0.36 micrograms/l). In the course of the LH-RH + TRH test there was an increase in the alpha subunit level both in the patients with alphoma associated with acromegaly and in the remaining cases of alphoma. Statistical analysis of the results obtained for the whole group of patients revealed a significant linear correlation between the alpha unit concentration 20, 30, 60 and 90 minutes following stimulation with the neurohormones and that before stimulation. For 9 patients with the acromegaly-associated tumors a statistically significant increase in the alpha subunit concentration was noted only at the 90-th minute of the stimulation test, while for the remaining 12 patients with alphoma an increase was statistically significant for the whole time of the duration of the test. In healthy subjects the concentration of alpha subunit never exceeded the limits of the normal values in the course of the LH-RH + TRH stimulation test.
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D000236:Adenoma / Q000097:blood* / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D005260:Female; D015292:Glycoprotein Hormones, alpha Subunit / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D010911:Pituitary Neoplasms / Q000097:blood* / Q000175:diagnosis; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone
D015292:Glycoprotein Hormones, alpha Subunit; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone
Zmiany stezenia podjednostki alfa hormonów glikoproteidowych w surowicy chorych z guzami przysadki typu "alfoma" w przebiegu testów stymulacji LH-RH + TRH.