Effects of felodipine on blood pressure and humoral factors in sodium-replete humans at rest and during exercise.
The effect of short-term calcium antagonism with felodipine on blood pressure and on plasma catecholamines, renin, and aldosterone was studied in 10 normal volunteers at rest and during incremental bicycle exercise. At rest, diastolic blood pressure was slightly increased during felodipine treatment, whereas systolic pressure and heart rate were not significantly changed. The plasma noradrenaline concentration and plasma renin activity were increased during felodipine treatment; the plasma adrenaline and aldosterone concentrations, on the contrary, were not significantly changed. The rises in plasma renin activity, plasma aldosterone, and plasma adrenaline and noradrenaline concentrations produced by exercise were not significantly affected by felodipine. It is concluded that the rise in plasma renin activity during calcium antagonism with felodipine is not accompanied by a significant increase in plasma aldosterone. Furthermore, the present data suggest that, at least during exercise, calcium antagonism does not interfere with the mechanisms underlying the exercise-induced activation of renin and aldosterone release.
Lijnen
P
P
Department of Pathophysiology, University of Leuven, Belgium.
Hespel
P
P
Fagard
R
R
Staessen
J
J
M'Buyamba-Kabangu
J R
JR
Moerman
E
E
Amery
A
A
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D015736:Felodipine; D006339:Heart Rate; D006801:Humans; D008297:Male; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D009638:Norepinephrine / Q000097:blood; D005082:Physical Exertion; D011897:Random Allocation; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000959:Antihypertensive Agents; D000450:Aldosterone; D009568:Nitrendipine; D012083:Renin; D015736:Felodipine; D009638:Norepinephrine