Generation of T cell repertoire. Two distinct mechanisms for generation of T suppressor cells, T helper cells, and T augmenting cells.
The present studies were carried out to characterize the influence of the T cell maturation environment on a repertoire of Th cells, T augmenting cells, and Ts cells, which were shown to construct a minimal regulatory circuit to regulate a helper function of class II-restricted Th cells. A repertoire of keyhole limpet hemocyanin-specific Th cells was influenced predominantly by I-A molecules of the T cell maturation environment, whereas a repertoire of T augmenting cells was determined by both I-A and I-E molecules. These repertoires were not influenced by the priming with Ag. A repertoire of Ts cell factor-producing Ts cells was not influenced by the T cell maturation environment, but rather was determined by the I-J haplotype of the APC utilized for priming with Ag. In contrast, a repertoire of novel cognate type Ts cells, which inhibit class II-restricted Th cell function in a restriction-restricted manner, was influenced by both I-A and I-E molecules of the T cell maturation environment. These results demonstrate the two distinct mechanisms for generating a T cell repertoire: a selection by class II molecules of the T cell maturation environment before the priming with foreign Ag and a selection by priming with APC and Ag.
Asano
Y
Y
Department of Immunology, Faculty of Medicine, University of Tokyo, Japan.
Tada
T
T
D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013491:Suppressor Factors, Immunologic / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000502:physiology
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D013491:Suppressor Factors, Immunologic; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin