Quality control of 125I-labelled fibrinogen of various species.
The modified chloramine-T method used for radioiodination of human, rat, and bovine fibrinogen guaranteed mild labelling conditions and a satisfactory labelling efficiency. The quality of the 125I-human, rat, and bovine fibrinogen preparations obtained met the requirements with respect to clottability, low content of 125Iodide as well as in vitro and in vivo stability.
Richter
M
M
Institute of Pharmacology and Toxicology, Medical Academy, Erfurt, GDR.
Cyranka
U
U
Walsmann
P
P
D000818:Animals; D002417:Cattle; D002700:Chloramines; D004591:Electrophoresis, Polyacrylamide Gel; D005340:Fibrinogen / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000592:standards*; D006801:Humans; D007457:Iodine Radioisotopes / Q000302:isolation & purification / Q000592:standards; D011786:Quality Control; D051381:Rats; D013045:Species Specificity; D013918:Thrombin Time; D014105:Tosyl Compounds
D002700:Chloramines; D007457:Iodine Radioisotopes; D014105:Tosyl Compounds; C016300:chloramine-T; D005340:Fibrinogen