Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: influence of histamine-rich food.
In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, N tau-methylhistamine and N tau-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary N tau-methylhistamine excretion is less affected by histamine-rich food-stuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.
Oosting
E
E
BCO Centre for Research, Breda, The Netherlands.
Keyzer
J J
JJ
Wolthers
B G
BG
D000328:Adult; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D006632:Histamine / Q000652:urine*; D006636:Histamine Release; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008297:Male; D008761:Methylhistamines / Q000652:urine; D013997:Time Factors
D007093:Imidazoles; D008761:Methylhistamines; C002667:methylimidazoleacetic acid; D006632:Histamine; D003404:Creatinine; C048140:N-methylhistamine