[Effect of inosine after early infusion of contrykal and heparin in various hemodynamic types of acute myocardial ischemia].
In 79 experiments with a canine model of acute 2-hour myocardial ischemia, a positive affect of inosine was found on parameters of cardiac bioelectrical activity, contractile and hemodynamic functions in normal and hypodynamic circulation. In excessive myocardial hyperfunction, inosine infusion led to aggravation of ischemic signs in the ischemic lesion zone and only to its modest decrease in the adjacent and intact segments of the myocardium. During pre-infusion of contrykal and heparin followed by inosine administration, there was a considerable decrease in ischemia in all myocardial areas, as evidenced by ECG and electrograms, no matter what the hemodynamic type of acute myocardial ischemia. As this took place, a particularly marked inosine-induced improvement was seen in myocardial contractility and relaxation, total and intracardiac hemodynamic parameters.
Korotkov
A A
AA
Zhorzholiani
T D
TD
Chkheidze
L G
LG
Shalamberidze
D N
DN
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007288:Inosine / Q000008:administration & dosage / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D011292:Premedication; D013268:Stimulation, Chemical; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D007288:Inosine; D006493:Heparin; D007611:Aprotinin
Effekt inozina na fone ranneĭ infuzii kontrikala i geparina pri razlichnykh gemodinamicheskikh variantakh techeniia ostroĭ ishemii miokarda.