Actinic reticuloid: immunohistochemical analysis of the cutaneous infiltrate in 13 patients.
An immunohistological study on cryostat sections of skin biopsies in 13 patients with actinic reticuloid has been performed using a panel of 21 monoclonal antibodies against lymphoid and non-lymphoid infiltrate cells. The infiltrate consisted of activated T cells, numerous histiocytes and macrophages, and small numbers of B cells. In 10 out of 13 patients the majority of the lymphocytes expressed the phenotype of suppressor cells. The number of Leu 8+ cells was inversely proportional to HLA-DR expression by the dermal infiltrate, which suggested a negative correlation between a state of activation and the concentration of Leu 8+ cells. There was a striking number of IgE bearing dendritic cells in the dermis associated with elevated serum IgE levels.
Toonstra
J
J
Department of Dermatology, University Hospital, Utrecht, The Netherlands.
Van der Putte
S C
SC
van Wichen
D F
DF
van Weelden
H
H
Henquet
C J
CJ
van Vloten
W
W
D000368:Aged; D000911:Antibodies, Monoclonal; D004817:Epidermis / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007633:Keratins; D007801:Langerhans Cells / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000911:Antibodies, Monoclonal; D007633:Keratins