A new AT III-heparin-complex preparation: in vitro and in vivo characterisation.
The in vitro experiments show that the anticoagulant affect of a new AT III-Heparin-complex preparation in plasma is similar to heparin. The in vivo experiments indicate that the thrombin inhibition is even improved by using the complex preparation, because the aPTT values after complex treatment remained stable for more than one hour in the desired range. Bleeding complications are less likely after complex treatment, because much smaller maximum aPTT values are reached. The prolonged half life of the complex preparation possibly allows a reduced and more accurate dosage.
Spannagl
M
M
Internal Clinic Innenstadt, Munich University, FRG.
Keller
R
R
Schramm
W
W
D000818:Animals; D000990:Antithrombin III / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D007123:Immunoelectrophoresis, Two-Dimensional; D046911:Macromolecular Substances; D008297:Male; D010314:Partial Thromboplastin Time; D011817:Rabbits; D013917:Thrombin / Q000037:antagonists & inhibitors
D046911:Macromolecular Substances; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin