Clinical use of hirudin.
The pharmacokinetics and the effects on the haemostatic system of hirudin were assessed in healthy volunteers after single doses of 1,000 AT-U/kg administered intravenously respectively subcutaneously. First clinical experiences on hirudin treatment in chronic DIC are reported.
Vogel
G
G
Department of Haemostaseology, Medical Academy Erfurt, GDR.
Markwardt
F
F
D000328:Adult; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000188:drug therapy; D006487:Hemostasis / Q000187:drug effects; D006629:Hirudins / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged
D006629:Hirudins