Palmitoyl-CoA inhibits the mitochondrial inner membrane anion-conducting channel.
Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 microM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolites. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochondria.
Halle-Smith
S C
SC
School of Biological Sciences, University of East Anglia, Norwich, England.
Murray
A G
AG
Selwyn
M J
MJ
D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000818:Animals; D000838:Anions / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010169:Palmitic Acids / Q000494:pharmacology; D010171:Palmitoyl Coenzyme A / Q000494:pharmacology*; D010172:Palmitoylcarnitine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000214:Acyl Coenzyme A; D000838:Anions; D003470:Culture Media; D007473:Ion Channels; D010169:Palmitic Acids; D010171:Palmitoyl Coenzyme A; D010172:Palmitoylcarnitine