Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity.
A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin-induced pneumonitis and Stevens-Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.
Brodsky
A
A
Department of Internal Medicine, Hospital de Clínicas José de San Martin, School of Medicine, University of Buenos Aires, Argentina.
Aparici
I
I
Argeri
C
C
Goldenberg
D
D
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D012127:Respiratory Distress Syndrome, Newborn / Q000139:chemically induced* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D001761:Bleomycin; D002945:Cisplatin