Modulation of experimental allergic encephalomyelitis by a host-versus-graft reaction: a clinicopathological study.
The effect of timing of a local host-versus-graft reaction on the induction of acute experimental allergic encephalomyelitis (EAE) was studied in guinea pigs. 20 x 10(7) gamma-irradiated allogeneic cells injected 4 days after encephalitogenic challenge resulted in the development of EAE with an earlier onset, an increased delayed-type hypersensitivity (DTH) response and an increase in lymphoid cell infiltration in the spinal cord. Challenge with allogeneic cells on days -4 and -7, however, produced a delay in onset and a protracted course of disease, with 30-40% of the animals recovering. Evidence of disease was confirmed histologically.
Staykova
M
M
Institute of Cell Biology and Morphology, Sofia, Bulgaria.
Kozovska
M
M
Shikova
E
E
Goranov
I
I
D000818:Animals; D004247:DNA / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D005620:Freund's Adjuvant / Q000276:immunology; D006087:Graft vs Host Reaction / Q000502:physiology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D009994:Osmolar Concentration; D013116:Spinal Cord / Q000378:metabolism
D004676:Myelin Basic Protein; D004247:DNA; D005620:Freund's Adjuvant