title: Pathogenicity of antigenic variants of Newcastle disease virus Italian strain selected with monoclonal antibodies.
abstract: Antigenic variants of the Italian strain of NDV were selected using monoclonal antibodies directed against the HN and F proteins of Italian virus. Antigenic mapping of the HN and F proteins using variant viruses in cross neutralization tests revealed the presence of at least two different epitopes on HN and four epitopes on F protein. Immunoselected variant viruses were demonstrated to have different intravenous pathogenicity index than the parental Italian virus.
authors: National Institute for Veterinary Research, Brussels, Belgium.
authors: G
authors: G
authors: Meulemans
authors: M
authors: M
authors: Gonze
authors: M C
authors: MC
authors: Carlier
authors: P
authors: P
authors: Petit
authors: A
authors: A
authors: Burny
authors: L E
authors: LE
authors: Long
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D000940:Antigenic Variation; D000939:Epitopes / Q000032:analysis*; D006389:Hemagglutinins, Viral / Q000032:analysis; D009522:Newcastle disease virus / Q000032:analysis / Q000276:immunology* / Q000472:pathogenicity; D014760:Viral Fusion Proteins / Q000032:analysis; D014774:Virulence
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D006389:Hemagglutinins, Viral; D014760:Viral Fusion Proteins