Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.
The mammalian c-abl proto-oncogene produces mRNAs with 5' heterogeneity from two distinct promoters and the alternative splicing of variable 5' exons. By using quantitative RNase protection assays, the relative abundance of two major c-abl mRNAs, type I and type IV, in several mouse tissues and cell lines has been determined. Our results demonstrate that the level of type IV c-abl mRNA is rather constant, whereas that of the type I mRNA varies over a 10-fold range in different tissues and cell types. This finding has interesting implications for the function of the two c-abl proteins.
Renshaw
M W
MW
Department of Biology, University of California-San Diego, La Jolla 92093.
Capozza
M A
MA
Wang
J Y
JY
D000818:Animals; D002460:Cell Line; D005091:Exons; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl; D012313:RNA; D016372:RNA, Antisense; D012333:RNA, Messenger / Q000235:genetics; D014018:Tissue Distribution
D011518:Proto-Oncogene Proteins; D016372:RNA, Antisense; D012333:RNA, Messenger; D012313:RNA; D016315:Proto-Oncogene Proteins c-abl