Paraneoplastic limbic encephalopathy with testicular carcinoma. A reversible neurologic syndrome.
Limbic encephalitis (encephalopathy) is a rare paraneoplastic syndrome which rarely responds to antineoplastic therapy. The authors report the first case of limbic encephalopathy associated with testicular carcinoma and the first histologically confirmed encephalopathy which responded to antineoplastic therapy of the associated neoplasm. The clinical and pathologic characteristics of paraneoplastic encephalopathies are discussed along with the potential for reversal of the neurologic process with effective antitumor therapy.
Burton
G V
GV
Duke University Medical Center, Department of Medicine, Durham, North Carolina.
Bullard
D E
DE
Walther
P J
PJ
Burger
P C
PC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D004660:Encephalitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide