Influence of selected antibiotics on interferon synthesis.
This paper discusses the influence of antibiotics - penicillin, streptomycin and mitomycin C - on interferon synthesis in vivo and in vitro. None of the antibiotics investigated was interferon inducer either in the suspension of human leukocytes or in the culture of cutaneo-muscular tissue from human embryo (HAT), or in mouse organism. However, the in vitro experiments revealed inhibitory effect of streptomycin and mitomycin C on the production of Newcastle disease virus (NDV) - stimulated interferon. Noteworthy is that the inhibition was most pronounced when the drug was administered simultaneously with the virus in the case of streptomycin or 24 h before the inducer in the case of mitomycin C. On the other hand, penicillin when introduced to the culture, exerted negligible modulatory effect on NDV-stimulated IFN.
Zielińska-Jenczylik
J
J
Department of Immunology and Infectious Diseases, Polish Academy of Sciences, Wrocław.
Sypuła
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008937:Mitomycins; D010406:Penicillins; D016685:Mitomycin; D007372:Interferons; D013307:Streptomycin