title: First experiences in application of RFLP analysis for carrier detection in preparation of prenatal diagnosis of hemophilia A in the GDR.
abstract: The application of the intragenic probe F8 e16-19 of factor VIII gene is reported for carrier detection in preparation of prenatal diagnosis of hemophilia A in a family at risk. The proband's mother is heterozygous for the Bcl I polymorphism and prenatal diagnosis can be offered to this family.
authors: Institute of Medical Genetics, Ernst-Moritz-Arndt-University, Greifswald, GDR.
authors: F H
authors: FH
authors: Herrmann
authors: T
authors: T
authors: Kruse
authors: M
authors: M
authors: Wehnert
authors: G
authors: G
authors: Vogel
authors: K
authors: K
authors: Wulff
mesh_terms: D015342:DNA Probes; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D005859:Germany, East; D006467:Hemophilia A / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D015342:DNA Probes