Alteration in stereological density parameters of the mucosal vascular bed during neoplastic transformation in sublingual keratosis.
Stereological techniques have been used to study the vascularity in 110 sublingual keratosis lesions and 22 specimens of normal sublingual mucosa using an image analysis system "IBAS 1". The stereological parameters volume density (Vv), and surface density (Sv) were significantly increased in sublingual keratosis lesions as compared with those of normal sublingual mucosa. Lesions that eventually underwent malignant change showed the highest values and were highly significant (p less than .001) when compared with those which did not do so. The present results demonstrate that vascularity could be a supportive marker of impending malignant change in sublingual keratosis lesions.
Tawfik
A M
AM
Department of Oral Pathology, Institute of Dental Surgery, London, England.
el-Labban
N G
NG
Lee
K W
KW
D001808:Blood Vessels / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007972:Leukoplakia, Oral / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009060:Mouth Floor; D009061:Mouth Mucosa / Q000098:blood supply* / Q000382:microbiology; D013223:Statistics as Topic
D007633:Keratins