Acute-phase response to scalding: changes in serum properties and acute-phase protein concentrations.
The time course of changes in the concentrations of individual acute-phase proteins (APRs) in the plasma was examined in the model of rats exposed to a single (sublethal) and repeated (fatal) scalding. These data were interrelated with the rate of survival, plasma volume, corticosterone level, and immunosuppressive potency of the serum. The infliction of a sublethal scalding composing 20% body surface area resulted in an initial 50% reduction of the plasma volume and a severalfold increase of the corticosterone level and immunosuppressive activity of the serum. A subsequent normalisation of these deviations proceeded in parallel with an increased rate of APR synthesis. An early infliction of a second scald was fatal. It led to a 60% reduction of the plasma volume, a lack of plasma APRs, and an additional enhancement of the immunosuppressive activity of serum.
Sevaljević
L
L
Institute for Biological Research, Belgrade, Yugoslavia.
Petrović
M
M
Bogojević
D
D
Savić
J
J
Pantelić
D
D
D000209:Acute-Phase Proteins / Q000097:blood* / Q000494:pharmacology; D000818:Animals; D002056:Burns / Q000097:blood* / Q000503:physiopathology; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D006023:Glycoproteins / Q000494:pharmacology; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000166:cytology
D000209:Acute-Phase Proteins; D006023:Glycoproteins; D003208:Concanavalin A; D003345:Corticosterone