Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.
1. The effect of propranolol on the clenbuterol-induced protein anabolism in innervated and denervated soleus and plantaris muscles of the rat was studied. 2. The response to the beta-agonist, clenbuterol, in both innervated and denervated muscles, was not significantly inhibited by the beta-antagonist, propranolol. 3. The results provide further evidence to suggest that the action of clenbuterol on skeletal muscle protein accretion may not be directly mediated by beta-adrenoceptors.
Maltin
C A
CA
Rowett Research Institute, Bucksburn, Aberdeen.
Hay
S M
SM
Delday
M I
MI
Reeds
P J
PJ
Palmer
R M
RM
D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004983:Ethanolamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009121:Muscle Denervation; D024510:Muscle Development; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D004983:Ethanolamines; D009124:Muscle Proteins; D012313:RNA; D004247:DNA; D011433:Propranolol; D002976:Clenbuterol