Progressive loss of neuronal src protein in postnatal weaver and staggerer cerebellum.
Two forms of the c-src protein-tyrosine kinase, pp60c-src, are detectable in the central nervous system. One form pp60+, appears to be exclusively expressed in neurons and is characterized by insertion of 6 amino acids compared to its non-neuronal counterpart, pp60. These 2 proteins were studied in the mutant mouse strains weaver and staggerer with postnatal loss of cerebellar granular neurons. We found a continuous postnatal decline of the neuronal form of pp60c-src, pp60+, in the cerebellum of both mutants concomitant with the degeneration of cerebellar granule cells. This indicates that granular neurons provide the main source for pp60+ in the cerebellar cortex.
Wiestler
O D
OD
Department of Pathology, University of California, School of Medicine, La Jolla.
Trenkner
E
E
Walter
G
G
D000818:Animals; D015153:Blotting, Western; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009410:Nerve Degeneration; D011494:Protein Kinases / Q000096:biosynthesis* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src); D011519:Proto-Oncogenes; D013045:Species Specificity
D011518:Proto-Oncogene Proteins; D011494:Protein Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)