Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.
Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.
Lambert
M E
ME
Cold Spring Harbor Laboratory, New York 11724.
Ronai
Z A
ZA
Weinstein
I B
IB
Garrels
J I
JI
D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / Q000494:pharmacology; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D004249:DNA Damage; D004817:Epidermis / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D015395:Histocompatibility Antigens Class I; D006801:Humans; D007633:Keratins / Q000378:metabolism; D014466:Ultraviolet Rays
D015395:Histocompatibility Antigens Class I; D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; D007633:Keratins; D003513:Cycloheximide