Measurements of placental, decidual, and fetal proteins before and after chorionic villus sampling.
Circulating placental [human chorionic gonadotrophin (hCG), Schwangerschafts protein 1 (SP1), pregnancy-associated plasma protein A (PAPP-A), decidual (pregnancy protein 12 (PP12), and fetal alphafetoprotein (AFP)] proteins were measured immediately before and within 1 h in 18 women undergoing diagnostic chorionic villus sampling (CVS) in the first trimester. An elevation of serum AFP levels was consistently seen, while fluctuations in excess of 10 per cent of the pre-CVS levels of SP1 and PP12 were seen in the majority of patients. Fluctuations in hCG and PAPP-A were consistently less than 10 per cent of pre-CVS values. Post-CVS changes in levels were not apparently associated with any feature of the technique, the pregnancy, or its outcome (one missed abortion). As feto-maternal haemorrhage is a common event, anti-D should be offered to rhesus-negative women undergoing CVS. In the prediction of subsequent miscarriage, only hCG and PAPP-A measurements should be considered.
Stabile
I
I
Academic Unit of Obstetrics, London Hospital Medical College, U.K.
Warren
R
R
Rodeck
C
C
Grudzinskas
J G
JG
D000022:Abortion, Spontaneous / Q000175:diagnosis; D002352:Carrier Proteins / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood*; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis* / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis; D011379:Prognosis; D011446:Prospective Studies; D013002:Somatomedins / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis*
D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011257:Pregnancy Proteins; D013002:Somatomedins; D000509:alpha-Fetoproteins; D007334:Insulin-Like Growth Factor I; D011266:Pregnancy-Associated Plasma Protein-A