title: Sensitivity of human pulmonary mast cells obtained by bronchoalveolar lavage to immunological and nonimmunological histamine releasers.
abstract: We have studied the sensitivity of human pulmonary mast cells to some immunological and nonimmunological histamine releasers. The pulmonary mast cells were obtained by bronchoalveolar lavage (BAL) of nonasthmatic patients. Mast cells constituted about 1% of total cell population and were morphologically intact. These cells were highly sensitive to the challenge with anti-human IgE. They responded to calcium ionophore A23187, polymyxin B and concanavalin A, however the magnitude of histamine release was low. BAL mast cells were unresponsive to the compound 48/80.
authors: Department of Biogenic Amines, Polish Academy of Sciences, Lódź.
authors: E
authors: E
authors: Brezińska-Blaszcyk
authors: A
authors: A
authors: Gaik
authors: K
authors: K
authors: Rydzyński
authors: A
authors: A
authors: Szymański
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D000001:Calcimycin / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D008407:Mast Cells / Q000276:immunology*; D011112:Polymyxin B / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D003208:Concanavalin A; D007073:Immunoglobulin E; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D011112:Polymyxin B