Differential neuroendocrine responses to the 5-HT agonist m-chlorophenylpiperazine in Fawn-Hooded rats relative to Wistar and Sprague-Dawley rats.
The effect of various doses of the 5-HT agonist m-chlorophenylpiperazine (MCPP) on neuroendocrine function (prolactin and corticosterone responses) were compared in three different rat strains: Wistar, Sprague-Dawley (SD), and Fawn-Hooded (FH) rats. Administration of various doses of MCPP produced increases in plasma concentrations of prolactin and corticosterone in all three rat strains. The prolactin responses of FH rats to MCPP were significantly smaller than that of either Wistar or SD rats, while corticosterone responses were equivalent across all three strains. On the other hand, baseline concentrations of corticosterone, but not of prolactin, were significantly higher in FH animals relative to both Wistar and SD animals. There was no significant difference in either baseline hypothalamic concentrations of serotonin, 5-hydroxyindoleacetic acid, norepinephrine, or dopamine or brain concentrations of MCPP among these three rat strains. These findings support some other data indicating that FH rats, a strain with a peripheral platelet serotonin storage pool disorder, also possess alterations in some neuroendocrine functions which are modulated by serotonin.
Aulakh
C S
CS
Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Md.
Wozniak
K M
KM
Hill
J L
JL
Devane
C L
CL
Tolliver
T J
TJ
Murphy
D L
DL
D000818:Animals; D001923:Brain Chemistry; D003345:Corticosterone / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010879:Piperazines / Q000032:analysis / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*
D010879:Piperazines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D003345:Corticosterone