title: Expression of T-cell receptor antigens in mycosis fungoides and inflammatory skin lesions.
abstract: Using immunohistologic methods, we studied the expression of the T-cell receptor (TCR)-associated antigens CD3, TCR-beta, and TCR-delta by cutaneous T cells in mycosis fungoides (MF) (36 patients) and a variety of inflammatory diseases (16 patients). Most T cells in the inflammatory diseases and patch/plaque mycosis fungoides expressed the immunophenotype characteristic of the vast majority of mature peripheral T cells: CD3+ TCR-beta+ TCR-delta-. In contrast, abnormal CD3/TCR-beta antigen expression was seen in 3 of 6 cases (50%) of tumor stage mycosis fungoides. Furthermore, we were able to document its evolution from the normal pattern present in earlier patch/plaque lesions of the two cases in which serial biopsies were available for study. Divergence of epidermal versus dermal CD3/TCR-beta antigen expression was seen in 2 of 34 (6%) of biopsies of patch/plaque mycosis fungoides but not in inflammatory controls. The TCR-delta+ cells were generally rare regardless of diagnosis. We conclude that inflammatory skin diseases and most patch/plaque mycosis fungoides are typically composed of T lymphocytes that resemble mature peripheral T cells in regard to their expression of TCR-associated antigens. In contrast, aberrant patterns of TCR-associated antigen expression can be seen in tumor stage MF, and, more rarely in patch/plaque MF.
authors: Department of Dermatology, Stanford University, Medical Center, California.
authors: S A
authors: SA
authors: Michie
authors: E A
authors: EA
authors: Abel
authors: R T
authors: RT
authors: Hoppe
authors: R A
authors: RA
authors: Warnke
authors: G S
authors: GS
authors: Wood
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001706:Biopsy; D003872:Dermatitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007158:Immunologic Techniques; D009182:Mycosis Fungoides / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell