Potassium release in labial glands from controls and patients with cystic fibrosis.
Labial glands from patients with cystic fibrosis (CF) were tested for a disease-related decrease in cholinergically-induced K release. Labial gland slices from normal controls and patients with cystic fibrosis were incubated in vitro in the presence or absence of cholinergic and adrenergic agonists and with or without a phosphodiesterase inhibitor. Both control and CF glands released K in response to cholinergic stimulation only; no K release response was detected to alpha- or beta- adrenergic stimulation. In contrast to previous results reported for parotid glands, no CF-related decrease in cholinergically-induced K release was detected. Both normal and CF glands released significantly less K with carbachol stimulation in the presence of the phosphodiesterase inhibitor. Overall, the results suggest considerable interglandular differences in disease sensitivity and functional regulation of K release.
Izutsu
K T
KT
Department of Oral Biology, School of Dentistry, University of Washington, Seattle.
Ensign
W Y
WY
Ramsey
B W
BW
Schubert
M M
MM
Allan
B J
BJ
Truelove
E L
EL
D015056:1-Methyl-3-isobutylxanthine; D002217:Carbachol; D003550:Cystic Fibrosis / Q000378:metabolism*; D006801:Humans; D011188:Potassium / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism*; D012470:Salivary Glands, Minor / Q000378:metabolism*
D002217:Carbachol; D011188:Potassium; D015056:1-Methyl-3-isobutylxanthine