Biochemical study on the postnatally developing mouse liver after a low level tritiated (HTO) in utero exposure.
Pregnant mice were continuously irradiated (0.3 microCi (11.1 kBq)/ml of drinking HTO) from the 16th day post coitum. Biochemical studies were made on liver of mice 1 to 6 weeks post partum. RNA content increased significantly at 1 and 2 weeks while it decreased at later intervals. DNA concentration decreased till 4 weeks but at 5th and 6th week it increased by 3.70% and 22.64%, respectively. Protein content showed biphasic pattern whereas, cholesterol concentration increased after irradiation.
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D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D008099:Liver / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D014316:Tritium; D014867:Water
D011506:Proteins; D014867:Water; D014316:Tritium; D012313:RNA; D004247:DNA; D002784:Cholesterol