title: The development of action lines in an Australian maternal serum alphafetoprotein screening service for neural tube defects.
abstract: A retrospective study covering the period from January 1, 1980 up to June 30, 1982 was conducted, producing the first definitive normal range for maternal serum alphafetoprotein from the Royal North Shore Hospital in Sydney. The normal range established is based on and applicable to the pregnant women tested at this NSW laboratory. Maternal serum alphafetoprotein levels had been determined by radioimmunoassay for 3,182 pregnancies between 13 and 20 weeks' gestation. Five anencephalics and 2 open spina bifidas were noted in the study. Only one of these abnormalities (spina bifida) was associated with maternal serum alphafetoprotein levels within the normal range, the remainder all having elevated levels. Low false positive and false negative rates of 1.16% and 0.03% respectively were obtained in this study.
authors: Department of Obstetrics and Gynaecology, Royal North Shore Hospital of Sydney, St. Leonards, NSW.
authors: T
authors: T
authors: Nicolas
authors: E M
authors: EM
authors: Nicholls
authors: R D
authors: RD
authors: Robertson
authors: M
authors: M
authors: Bonifacio
authors: M
authors: M
authors: Sinosich
authors: B
authors: B
authors: Field
authors: D M
authors: DM
authors: Saunders
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D009436:Neural Tube Defects / Q000097:blood / Q000517:prevention & control*; D009517:New South Wales; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012016:Reference Values; D016136:Spina Bifida Occulta / Q000517:prevention & control; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins