title: Origin of sympathetic and sensory innervation of the knee joint. A retrograde axonal tracing study in the rat.
abstract: The origin of sympathetic and sensory innervation of the knee joint was investigated by the intra-axonal transport method. After injection of horseradish peroxidase (HRP) or horseradish peroxidase conjugated to wheat germ agglutinin (WGA-HRP) into the knee joint unilaterally in adult rats, labelled neurons were found ipsilaterally both in sympathetic and dorsal root ganglia at the lower thoracic and lumbosacral levels. A maximum of 1500 and 1000 peroxidase-positive cells were observed in the sympathetic and dorsal root ganglia, respectively; in the former they were mainly located at the levels of L2-L4, and in the latter mainly at L3-L5. The functional implications of the above observations are discussed in relation to pain mechanisms in joints and to the earlier hypothesis that a nervous component might be involved in the pathogenesis of chronic joint inflammation.
authors: Department of Plastic Surgery, Uppsala University Hospital, Sweden.
authors: B
authors: B
authors: Widenfalk
authors: M
authors: M
authors: Wiberg
mesh_terms: D000818:Animals; D005727:Ganglia, Spinal / Q000033:anatomy & histology; D005728:Ganglia, Sympathetic / Q000033:anatomy & histology; D006735:Horseradish Peroxidase; D007719:Knee Joint / Q000294:innervation*; D009434:Neural Pathways / Q000033:anatomy & histology; D009475:Neurons, Afferent / Q000166:cytology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000033:anatomy & histology*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase