title: Lesional keratinocytes express OKM5, Leu-8 and Leu-11b antigens in lichen planus.
abstract: Biopsy specimens of involved and uninvolved skin were studied in 16 patients with lichen planus using murine monoclonal antibodies against several cell surface markers of effector and/or accessory cells of the immune system. In contrast to uninvolved skin, keratinocytes were found to express HLA-DR, OKM5, Leu-8 and Leu-11b antigens in all biopsies from involved skin. We demonstrate here for the first time the in vivo expression of several effector and/or accessory cell markers on keratinocytes in lichen planus.
authors: Department of Dermatology, University of Erlangen-Nürnberg, FRG.
authors: M
authors: M
authors: Simon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D018955:CD36 Antigens; D016827:CD8 Antigens; D000078404:Epidermal Cells; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007633:Keratins / Q000276:immunology*; D008010:Lichen Planus / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D018955:CD36 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D007633:Keratins