Histamine liberation and aggregation of rabbit blood platelets treated with beta-adrenoceptor blocking drugs.
The liberation of histamine from rabbit blood platelets during aggregation as well as the effect of propranolol and atenolol on this process was investigated. Thrombin, but not ADP, liberated histamine from platelets in a dose-dependent manner. This liberation was influenced by beta-adrenoceptor blocking drugs and some modes of action are discussed.
Jancinová
V
V
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Nosál
R
R
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000244:Adenosine Diphosphate; D013917:Thrombin