title: Bradykinin induced wheal and flare is not mediated by histamine release or cyclooxygenase products.
abstract: The wheal and flare response to intradermal bradykinin was studied in man. The possibility that histamine and cyclooxygenase products are involved in the response to bradykinin was examined. Terfenadine given by mouth significantly inhibited the cutaneous response to histamine but the effect of bradykinin was unaltered. Similarly the cutaneous response to bradykinin was unchanged by aspirin.
authors: Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
authors: D C
authors: DC
authors: Crossman
authors: R W
authors: RW
authors: Fuller
mesh_terms: D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001920:Bradykinin; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012882:Skin Tests; D016593:Terfenadine
chemical_list: D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D006632:Histamine; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin; D001920:Bradykinin