Immunohistochemical localisation of alpha-1-protease inhibitor in the horse.
Using a peroxidase anti-peroxidase technique alpha-1-protease inhibitor (alpha-1-PI) was identified in normal equine hepatocytes in formalin-fixed liver sections, and in airway secretions and macrophages in formalin-fixed lung sections of horses with chronic small airway disease and chronic bronchointerstitial pneumonia. In addition, it was identified occasionally in macrophages in bronchoalveolar lavage samples from clinically healthy horses and from horses with chronic small airway disease. Equine peripheral blood leucocytes and formalin-fixed lung sections with normal histology were negative for alpha-1-PI.
Winder
N C
NC
Institute of Veterinary Physiology, University of Zurich, Switzerland.
Pellegrini
A
A
von Fellenberg
R
R
D000209:Acute-Phase Proteins / Q000032:analysis*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses / Q000033:anatomy & histology*; D007124:Immunoenzyme Techniques; D008099:Liver / Q000032:analysis*; D008168:Lung / Q000032:analysis*; D008171:Lung Diseases / Q000473:pathology / Q000662:veterinary*; D011480:Protease Inhibitors / Q000032:analysis*; D000515:alpha 1-Antitrypsin
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin