title: Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats.
abstract: Unilateral removal of the afferent fibers of the IXth and Xth cranial nerve (nodose ganglionectomy) caused significant decrease in the content of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in the nucleus tractus solitarii (NTS) of rats. Microinjection of SP (1 ng) or NKA (10-100 ng) into the NTS caused prompt, transient hypotension and bradycardia, suggesting that SP and NKA may be neurotransmitters of the baroreceptor reflex in the NTS. NKB-like immunoreactivity (NKB-LI) was also detected in the NTS of rats by radioimmunoassay, but its content in the NTS was not affected by unilateral nodose ganglionectomy. The microinjection of 1-10 ng of suc-[Asp5, Me-Phe8]-SP(6-11) (senktide, a selective neurokinin B receptor peptide) into the NTS caused long-lasting hypertension and tachycardia. These results indicate that NKB may also be a neuromodulator on cardiovascular responses in the NTS.
authors: Department of Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Japan.
authors: A
authors: A
authors: Nagashima
authors: Y
authors: Y
authors: Takano
authors: K
authors: K
authors: Tateishi
authors: Y
authors: Y
authors: Matsuoka
authors: T
authors: T
authors: Hamaoka
authors: H
authors: H
authors: Kamiya
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008845:Microinjections; D015288:Neurokinin A / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D015287:Neurokinin B / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; C054724:senktide; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B