The gene coding for proteins HC and HI-30 of inter-alpha-trypsin inhibitor maps to 9q22.3----q33.
Proteins HC and HI-30 of inter-alpha-trypsin inhibitor light chain are two plasma proteins. They are encoded by the same monocistronic mRNA. Their function is probably related to the regulation of immunologic and/or inflammatory responses. Using a genomic DNA probe and a panel of somatic cell hybrids we have mapped the gene coding for the proteins to chromosome 9. In situ hybridization experiments refined the assignment to the region 9q22.3----q33.
Traboni
C
C
Dipartimento di Biopatologia Umana, La Sapienza, Rome, Italy.
Tosini
F
F
Covone
A
A
Romeo
G
G
Rocchi
M
M
D000510:Alpha-Globulins / Q000235:genetics*; D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D008677:Metaphase; D009693:Nucleic Acid Hybridization
D000510:Alpha-Globulins; C016001:alpha-1-microglobulin; C011877:inter-alpha-inhibitor