The expression of genes coding for positive acute-phase proteins in the reproductive tract of the female rat. High levels of ceruloplasmin mRNA in the uterus.
High levels of ceruloplasmin mRNA were measured in the uterus of both pregnant and non-pregnant rats. No mRNA for alpha 2-macroglobulin and alpha 1-acid glycoprotein could be detected in the uterus in contrast to the high levels of those two mRNAs found in the decidua in the mid-gestation period. Synthesis of plasma proteins with a protective function in the decidua or uterus may be important in maintaining homeostasis at different stages of reproduction. In addition, ceruloplasmin synthesis by the uterus may be part of a system transporting copper to the fetus.
Thomas
T
T
Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, VIC, Australia.
Schreiber
G
G
D000209:Acute-Phase Proteins / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002570:Ceruloplasmin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D003656:Decidua / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006706:Homeostasis; D009961:Orosomucoid / Q000235:genetics; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D014168:Transferrin / Q000235:genetics; D014599:Uterus / Q000378:metabolism*; D015017:Yolk Sac / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000235:genetics
D000209:Acute-Phase Proteins; D009961:Orosomucoid; D012333:RNA, Messenger; D014168:Transferrin; D000511:alpha-Macroglobulins; D002570:Ceruloplasmin