Platelet aggregation, rheological parameters and blood glucose profiles in diabetic children (type I) treated with human and porcine insulin.
In a three-year bicentric cross-sectional investigation on type I diabetic children between six and eighteen years of age, blood sugar profiles and spontaneous thrombocyte aggregation were assessed besides anamnestic and clinical data. In the children treated with human insulin raised spontaneous thrombocyte aggregation was significantly more frequent than in those treated with porcine insulin. At the same time blood sugar fluctuation from day to day measured between seven and nine a.m. tended to be raised in the children treated with human insulin; the fluctuation in the diurnal profile measured for fourteen days was indeed very much greater. Since the two groups were comparable as to sex distribution, age, duration of disease, quality of compensation, application and dose of insulin, the greater fluctuation of blood sugar in the children treated with human insulin appears to be the cause for the raised spontaneous thrombocyte aggregation.
Leipnitz
G
G
Department of Clinical Hemostaseology and Transfusion Medicine, University of Saarland, Homburg/Saar, FRG.
Jung
F
F
Lawall
H
H
Kiesewetter
H
H
Knoop
U
U
Schöneberger
H J
HJ
Frank
M
M
Hellstern
P
P
Sitzmann
F C
FC
Wenzel
E
E
D000293:Adolescent; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001809:Blood Viscosity / Q000187:drug effects*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D013552:Swine
D001786:Blood Glucose; D007328:Insulin