[Intragastric provocation and antigen-induced in vitro histamine liberation by the food additive E 102].
Adverse reactions to tartrazine have been known since 1958. The mechanism of this reaction, a not IgE-mediated, anaphylactoid reaction, is not fully understood. The demonstration of this adverse reaction by provocative challenge feeding may be problematic by a score of subjective symptoms because of the placebo effect. This report deals with the intragastral provocation under endoscopic control with tartrazine and tartrazine-induced histamine release in vitro from gastric mucosa and from blood. Two patients with anamnestically suspected adverse reactions to tartrazine were studied. Correspondence of in vivo and in vitro testing with tartrazine could be demonstrated.
Schaubschläger
W
W
Medizinische Klinik des Forschungsinstituts Borstel.
Ruschmeyer
J
J
Zabel
P
P
Schlaak
M
M
D001391:Azo Compounds / Q000009:adverse effects*; D005503:Food Additives; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D006636:Histamine Release; D006801:Humans; D013645:Tartrazine / Q000009:adverse effects* / Q000494:pharmacology
D001391:Azo Compounds; D005503:Food Additives; D013645:Tartrazine
Intragastrale Provokation und Antigeninduzierte Histaminfreisetzung in vitro mit Lebensmittelfarbstoff E 102.