Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells.
We have identified a suppressive element in the upstream region of the interleukin 2 (IL-2) receptor L chain (Tac) promoter. The inhibitory activity of this element was retained in human T cell leukemia virus type-1 (HTLV-1)-infected T cell lines which express constitutively a large number of IL-2 receptors on the cell surface. The promoter activities of the IL-2 receptor gene did not always correlate with the strong expression of the receptor and its mRNA in the HTLV-1-infected T cell lines we analysed. The results indicate that the constitutive up-regulation of the IL-2 receptor in HTLV-1-infected T cells may be ascribed to not only the transcriptional but also post-transcriptional regulation.
Kanamori
H
H
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto, Japan.
Suzuki
N
N
Ishida
N
N
Honjo
T
T
D005786:Gene Expression Regulation; D015490:HTLV-I Infections / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D012313:RNA / Q000032:analysis / Q000302:isolation & purification; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D014158:Transcription, Genetic; D014162:Transfection
D015375:Receptors, Interleukin-2; D012313:RNA