Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain.
The distribution of transforming growth factor (TGF)-alpha and TGF-beta 1 mRNA containing cells in adult mouse brain was examined using in situ hybridization histochemistry. There were no detectable TGF-beta 1 mRNA-containing cells found in the brain. TGF-alpha mRNA was localized to cell bodies of the caudate nucleus, dentate gyrus, anterior olfactory nuclei, and a laminar distribution of mitral cells in the olfactory bulb. TGF-alpha-synthesizing cells were localized in brain regions that have been shown to synthesize nerve growth factor, epidermal growth factor (EGF) and enkephalins. The function of local synthesis of TGF-alpha in the brain is as yet unknown.
Wilcox
J N
JN
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
Derynck
R
R
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics*; D012313:RNA; D012333:RNA, Messenger / Q000378:metabolism*; D015291:Transforming Growth Factors
D010455:Peptides; D012333:RNA, Messenger; D012313:RNA; D015291:Transforming Growth Factors