[Invasive thymoma with pulmonary metastasis. Complete remission 5 years after surgery and chemotherapy using the CHOP-BLEO protocol].
We report a case of invasive lympho-epithelial thymoma with pulmonary metastases, treated by complete macroscopic excision of primary tumour and then by chemotherapy using CHOP-BLEO. The epithelial nature of the tumour was confirmed by immunohistochemical studies. Chemotherapy enabled a complete and prolonged remission (greater than 63 months). Therapeutic trials of CHOP-BLEO merit further assessment and the results should be compared to the baseline treatment using platinum and prednisolone.
Wurtz
A
A
Clinique chirurgicale Ouest (Chirurgie A), Hôpital Claude-Huriez, CHU, Lille.
Ramon
P
P
Chambon
J P
JP
Wallaert
B
B
Gosselin
B
B
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009361:Neoplasm Invasiveness; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D013945:Thymoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000601:surgery*; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
Thymome invasif avec métastases pulmonaires. Rémission complète à 5 ans par chirurgie et chimiothérapie par le protocole CHOP-BLEO.