Additive effects of diuretics or sodium restriction with calcium channel blockers in the treatment of hypertension.
The role of dietary sodium intake and diuretic administration on the blood pressure response to calcium channel blockers (CCB) is reviewed. CCB has been shown to have a natriuretic effect irrespective of sodium balance state. Sodium-sensitive hypertensives often have lower blood pressure levels after dietary sodium restriction or diuretic therapy, making the additive benefit of CCB on blood pressure more difficult to discern. The majority of studies including appropriate controls suggest that CCBs of the dihydropyridine class (nifedipine and nitrendipine) and also verapamil have an antihypertensive effect that can be augmented by diuretic administration.
Weinberger
M H
MH
Hypertension Research Center, Indiana University School of Medicine, Indianapolis 46223.
D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004039:Diet, Sodium-Restricted; D004232:Diuretics / Q000627:therapeutic use*; D004357:Drug Synergism; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*
D002121:Calcium Channel Blockers; D004232:Diuretics