Effects of the Chinese herbal medicine "saiboku-to" on histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80.
The herbal medicine "Saiboku-to" (ST) has been used for the treatment of bronchial asthma. ST was found to inhibit histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. Its inhibitory effects were concentration-related and somewhat weaker than disodium cromoglycate, a known inhibitor of histamine release and mast cell degranulation. From these results, ST could appear to be useful in the treatment of Type I allergic reactions.
Toda
S
S
Department of Pharmaceutical Science, Kansai Shinkyu Medical College, Osaka, Japan.
Kimura
M
M
Ohnishi
M
M
Nakashima
K
K
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D010529:Peritoneal Cavity; D003189:p-Methoxy-N-methylphenethylamine
D004365:Drugs, Chinese Herbal; D003189:p-Methoxy-N-methylphenethylamine