Elevated haemoglobin F in juvenile and adult chronic myelogenous leukaemia.
Fetal haemoglobin (Hb F) and its G gamma-globin chain contents were examined in 2 juvenile (JCML) and 9 adult chronic myelogenous leukaemia (ACML) patients. One JCML patient's %Hb F was 28.0% and its %G gamma was 41.8%, while another JCML patient's %Hb F was 58.0% and its %G gamma was 65.6%. Four ACML patients gamma-globin gene arrangements in all cases were normal. The presence of the Xmn I site 5' to the G gamma-globin gene (at-158 base pairs from the G gamma-globin gene cap site) was observed only in 1 typical JCML patient with elevated %G gamma. The subhaplotype 5' to the delta-globin gene in 5 ACML patients was [+----], and the other 4 were suspected to be heterozygotes for [+----] and [-++-+]. The frequency of the A gamma T-globin gene in ACML patients may be higher than in the normal Japanese population.
Shimizu
K
K
Institute for Developmental Research, Aichi Prefectural Colony, Kasugai, Japan.
Keino
H
H
Terasawa
T
T
Shichishima
T
T
Ikuta
K
K
Hayashi
Y
Y
D000328:Adult; D000368:Aged; D002675:Child, Preschool; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000302:isolation & purification; D005260:Female; D005319:Fetal Hemoglobin / Q000096:biosynthesis* / Q000235:genetics; D005914:Globins / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D005914:Globins; D005319:Fetal Hemoglobin; D004248:DNA (Cytosine-5-)-Methyltransferases