Selective inhibition by vasocortin of histamine release induced by dextran and concanavalin-A from rat peritoneal cells.
Vasocortin, a glucocorticoid-induced anti-inflammatory protein, has been purified from the peritoneal lavage fluid of dexamethasone-treated rats. Vasocortin inhibited the release of histamine from rat peritoneal cells stimulated by dextran or concanavalin A but did not alter the release induced by calcium ionophore A23187 or compound 48/80. This selective effect exhibited by vasocortin mimics the glucocorticoid inhibition of histamine release from rat mast cells.
Carnuccio
R
R
Department of Experimental Pharmacology, University of Naples, Italy.
Di Rosa
M
M
Ialenti
A
A
Iuvone
T
T
Sautebin
L
L
D000818:Animals; D017302:Annexins; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D013256:Steroids; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D017302:Annexins; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D011506:Proteins; D013256:Steroids; C052038:vasocortin; D003208:Concanavalin A; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine