[Sterility and tumors of the testis. Study of late exocrine and endocrine functions in stage I or IIA tumors].
Spermatogenesis and plasma hormone levels (testosterone, follicle stimulating hormone and 17 beta estradiol) were studied in patients presenting stage I or IIA testicular tumors. Patients with a previous history of cryptorchidism or varicocele, and those who had received combined chemotherapy, were excluded. In 22 patients (10 seminomas and 12 non-seminoma tumors) a spermogram was obtained at the time of orchidectomy, before the procedure in 9 cases and immediately afterwards in 13. Hormone levels, together with tumor marker assay (alpha feto protein and beta HCG) were determined preoperatively. Exocrine and endocrine function were restudied after 3 years of follow up. There was an initial restudied after 3 years of follow up. There was an initial deterioration in spermatogenesis in 17 patients (77.8%) as shown by a sperm count less than 20 million per cm3, an ejaculate volume less than 1.5 cm3 and a motility after one hour of less than 60%. In this group 11 patients had a sperm count of less than 10 million per cm3. Endocrine anomalies discovered included an increase in serum beta HCG levels (7 cases), combined with a decrease in follicle stimulating hormone and an increase in 17 beta estradiol. After 3 years, only 5 of these 17 patients demonstrated fertile sperm (29.4%). The endocrine anomalies tended to regress after orchidectomy. While these endocrine anomalies were always accompanied by hypofertility, their absence was not synonymous with a normal spermogram. Thus the reestablishment of fertile sperm remains unlikely even in early stage testicular tumors.
Bouchot
O
O
Service d'Urologie, CHR, Nantes.
Plougastel
M L
ML
Karam
G
G
Bochereau
G
G
Auvigne
J
J
D000328:Adult; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000032:analysis / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D009367:Neoplasm Staging; D009919:Orchiectomy; D010446:Peptide Fragments; D013076:Sperm Count; D013091:Spermatogenesis; D013736:Testicular Neoplasms / Q000032:analysis / Q000473:pathology; D013739:Testosterone / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D000509:alpha-Fetoproteins; D013739:Testosterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone
Stérilité et tumeurs du testicule. Etude des fonctions exocrine et endocrine à distance dans les tumeurs de stade I et IIA.