Sensitivities of bleomycin-resistant variant cells enhanced by 40 degrees C hyperthermia in vitro.
Cultured mammalian cells of higher (mouse L) and lower (Chinese hamster V-79) sensitivities to bleomycin (BLM) were repeatedly treated with BLM (0.1 mg/ml), through which BLM-resistant variant strains were induced. Sensitivities of these variant strains to BLM were enhanced by simultaneous treatment with 40 degrees C hyperthermia.
Kano
E
E
Department of Experimental Radiology and Health physics, Fukui Medical University, Japan.
Furukawa-Furuya
M
M
Nitta
K
K
Kajimoto-Kinoshita
T
T
Picha
P
P
Sugimoto
K
K
Ohtsubo
T
T
Tsuji
K
K
Tsubouchi
S
S
Kondo
T
T
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002999:Clone Cells / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D051379:Mice; D013997:Time Factors
D001761:Bleomycin