[Alpha-fetoprotein and trisomy 21].
In 31 affected pregnancies with Down syndrome, the median maternal serum alpha-fetoprotein value was lower than normal, 0.76 MoM, and median amniotic fluid value was quite normal, 0.98 MoM. Selecting an arbitrary cutoff-point of 0.5 MoM, 4.1 percent of normal gestations show values less than 0.5 MoM. Authors discuss problems about screening for fetal Down's syndrome by measuring maternal serum AFP levels.
Guibaud
S
S
Laboratoire de Biochimie, Hôpital de la Croix-Rousse, Lyon.
Boisson
C
C
Simplot
A
A
Thoulon
J M
JM
Favier
J P
JP
Guibaud
P
P
Robert
J M
JM
D000653:Amniotic Fluid / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008403:Mass Screening; D011247:Pregnancy / Q000097:blood*; D011296:Prenatal Diagnosis; D012016:Reference Values; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D000509:alpha-Fetoproteins
Alpha-foetoprotéine et trisomie 21.