Molecular mechanism of endothelin-1 action on aortic cells.
The vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.
Van Renterghem
C
C
Centre de Biochimie du Centre National de la Recherche Scientifique, Nice, France.
Vigne
P
P
Barhanin
J
J
Schmid-Alliana
A
A
Frelin
C
C
Lazdunski
M
M
D000818:Animals; D001011:Aorta / Q000166:cytology*; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D004594:Electrophysiology; D016232:Endothelins; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D015220:Calcium Channels; D016232:Endothelins; D010455:Peptides; D002118:Calcium