Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow.
5-Hydroxyindoleacetic acid (5-HIAA), the major serotonin metabolite, was measured in human plasma and urine using liquid chromatography and electrochemical detection. The renal extraction of 5-HIAA was 78%, a value compatible with an almost complete extraction during a single passage of the blood through the kidney. In addition, plasma levels of 5-HIAA measured in patients with a wide range of renal function was inversely correlated (r = 0.85) with the clearance of para-aminohippuric acid (PAH). The results indicate that 5-HIAA determinations can be used as an alternative procedure to the PAH clearance method for the estimation of renal plasma flow in clinical practice.
Hannedouche
T
T
Department of Nephrology, Hôpital Necker-Enfants Malades, Paris, France.
Laude
D
D
Déchaux
M
M
Grünfeld
J P
JP
Elghozi
J L
JL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D007671:Kidney Concentrating Ability; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D010130:p-Aminohippuric Acid / Q000097:blood
D006897:Hydroxyindoleacetic Acid; D010130:p-Aminohippuric Acid