Sinoaortic denervation: serotonergic and cholinergic participation.
1. This review describes the role of serotonergic and cholinergic pathways in blood pressure regulation after sinoaortic denervation of rats. 2. The changes observed in serotonergic activity were related to the development and/or the maintenance of neurogenic hypertension. 3. The data indicate that baroreceptor deafferentation could affect the peripheral parasympathetic tone which regulates heart rate. 4. Moreover, there is evidence that brain cholinergic neurons may be involved in the process of neurogenic hypertension produced by sinoaortic denervation.
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Cátedra de Farmacología, Instituto de Investigaciones Farmacológicas (CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001923:Brain Chemistry; D003714:Denervation; D006339:Heart Rate; D006897:Hydroxyindoleacetic Acid / Q000502:physiology; D010277:Parasympathomimetics / Q000502:physiology; D010830:Physostigmine / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000502:physiology; D012850:Sinus of Valsalva / Q000294:innervation*; D014364:Tryptophan / Q000378:metabolism
D010277:Parasympathomimetics; D011985:Receptors, Serotonin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D010830:Physostigmine; D000109:Acetylcholine