title: Survival rate and development of fetuses during the first 30 days of gestation after folic acid addition to a swine diet.
abstract: At weaning, 162 sows were assigned randomly to six treatments (27 in each treatment) according to a 2 X 3 factorial arrangement: two levels of supplementary folic acid (0 and 5 mg/kg of diet) and three treatments to stimulate ovulation (none, flushing and pregnant mare serum gonadotropin [PMSG] injection). All sows were mated twice within 7 d after weaning. Of the 162 animals originally selected, 123 sows were pregnant and used in this trial. The flushing treatment consisted of allowing sows ad libitum access to feed from the day after weaning through the 1st day of behavioral estrus, whereas control animals received 2.4 kg of feed daily. The hormonal treatment consisted of one i.m. injection of 1,250 IU of PMSG the day after weaning. The commercial-type diet used as the control was computed to contain .6 mg folates per kilogram. Folic acid supplementation elevated (P less than .001) serum folates between weaning and 30 d of gestation. Fetuses of sows fed the diet supplemented with folic acid had a higher (P less than .05) total protein concentration than fetuses of control sows, whereas RNA and DNA concentrations and protein:DNA ratio were not affected. The PMSG treatment elevated (P less than .05) ovulation rate, whereas the flushing or folic acid treatments had no effect on this trait. The addition of 5 mg/kg folic acid to the commercial-type diet improved (P less than .05) the survival rate of fetuses during early gestation and tended (P = .096) to increase the number of fetuses presumably living at 30 d of gestation when this treatment was associated with high ovulation rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Université Laval, Québec, Canada.
authors: G F
authors: GF
authors: Tremblay
authors: J J
authors: JJ
authors: Matte
authors: J J
authors: JJ
authors: Dufour
authors: G J
authors: GJ
authors: Brisson
mesh_terms: D000704:Analysis of Variance; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D004247:DNA / Q000032:analysis; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005328:Fetal Viability / Q000187:drug effects*; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005527:Food, Fortified; D006064:Gonadotropins, Equine / Q000494:pharmacology; D008098:Litter Size / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D010298:Parity; D011247:Pregnancy; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D011897:Random Allocation; D013552:Swine / Q000196:embryology*
chemical_list: D006064:Gonadotropins, Equine; D011506:Proteins; D012313:RNA; D004247:DNA; D005492:Folic Acid