Calcium-binding proteins of the EF-type.
Calcium, acting as second messenger, are through-target proteins that contain an EF-hand structure. Based on this general principle, EF-hand structures can be predicted from the amino acid sequence of a protein. Most recently, several new members of the Ca2+-binding protein family have been discovered, e.g., the cystic fibrosis antigen (CFAg), the macrophage migration inhibitory factor related proteins (MRP-8 and -14), non-muscle alpha-actinin, and uvomorulin, the latter belonging to the group of cell adhesion molecules. Additionally, new information about the physiological functions of S-100 proteins, calbindins, calretinin as well as parvalbumin were observed and some of the these results are discussed.
Heizmann
C W
CW
Department of Pediatrics, University of Zürich, Switzerland.
D000818:Animals; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation
D002135:Calcium-Binding Proteins