[Immediate results of the use of prospidin in a cyanoacrylate glue compound in cancer of the esophagus].
Antitumor efficacy of a medical adhesive MK-8-based polymer drug composition with prospidin has been studied in 49 Wistar rats, and the kinetics of the drug elimination has been followed up in 112 rats. The findings evidence a prolongation of a relapse-free period and a longer survival of the animals. Clinical trials of the composition have been carried out. Of the 70 patients with esophageal carcinomas 52 ones had local disseminated forms, conforming to T4P3-4 indices. Application of the adhesive composition has not increased the rate of postoperative complications and in some cases considerably prolonged the life span of patients after palliative surgery.
Chissov
V I
VI
Mamontov
A S
AS
Rusakov
I G
IG
Shchitkov
K G
KG
Akimova
A Ia
AIa
Il'ina
A I
AI
Volokhov
A B
AB
Akhmetov
M M
MM
D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D002296:Carcinosarcoma / Q000601:surgery; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004341:Drug Evaluation; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010879:Piperazines / Q000008:administration & dosage*; D011183:Postoperative Complications; D011447:Prospidium / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000601:surgery; D014014:Tissue Adhesives / Q000008:administration & dosage*
D003487:Cyanoacrylates; D046911:Macromolecular Substances; D010879:Piperazines; D014014:Tissue Adhesives; C007166:cyacrin; D011447:Prospidium
Neposredstvennye rezul'taty primeneniia prospidina, deponirovannogo tsianakrilatnoĭ kleevoĭ kompozitsieĭ, pri rake pishchevoda.