title: Rat nucleolar 7-2 RNA is homologous to mouse mitochondrial RNase mitochondrial RNA-processing RNA.
abstract: 7-2 RNA (also termed RNA M and 7SM RNA) is a noncapped small RNA present in small ribonucleoprotein particles; these particles are present in the granular compartment of the nucleolus. Some sera from patients with scleroderma specifically immunoprecipitate 7-2 RNA-containing particles (Hashimoto, C., and Steitz, J. A. (1983) J. Biol. Chem. 258, 1379-1382; Reddy, R., Tan, E. M., Henning, D., Nohga, K., and Busch, H. (1983) J. Biol. Chem. 258, 1383-1386; Reimer, G., Raska, I., Scheer, U., and Tan, E.M. (1988) Exp. Cell Res. 176, 117-128). In this study, the primary sequence of Novikoff hepatoma 7-2 RNA was determined and a possible secondary structure is presented. The Novikoff hepatoma 7-2 RNA is 94% homologous to the recently described mouse mitochondrial RNase MRP RNA, suggesting that Novikoff hepatoma 7-2 RNA may be the homologue of mouse MRP RNA. The presence of 7-2 RNA in nucleoli and in mitochondria suggests that 7-2 ribonucleoproteins, in addition to being essential components of mitochondrial RNase, may also be functional in nucleolar RNA processing and ribosome biogenesis.
authors: Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030.
authors: Y
authors: Y
authors: Yuan
authors: R
authors: R
authors: Singh
authors: R
authors: R
authors: Reddy
mesh_terms: D000818:Animals; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002460:Cell Line; D002466:Cell Nucleolus / Q000032:analysis* / Q000201:enzymology; D005095:Exoribonucleases / Q000302:isolation & purification; D008113:Liver Neoplasms / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification*; D012323:RNA Processing, Post-Transcriptional; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000235:genetics / Q000302:isolation & purification*; D051381:Rats; D012260:Ribonucleases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D009841:Oligonucleotides; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal; D012342:RNA, Small Nuclear; D012313:RNA; D005095:Exoribonucleases; D012260:Ribonucleases; C042081:exoribonuclease T