[Interferon-inducing and immunostimulating activity of bonafton in an experiment].
It was shown for the first time that the antiviral drug bonafton administered orally to nonlinear albino mice in single doses of 5, 12.5 and 25 mg/kg induced production of interferon in the animal blood serum. The maximum interferon titer of 160-320 IU/ml was observed 18 hours after the drug administration in a dose of 12.5 mg/kg. In low doses of 5 to 12.5 mg/kg bonafton increased the nonspecific resistance of the mice to experimental viral infections when administered orally in single doses not earlier than 2 weeks prior to the contamination. The ability of the drug to stimulate the host protective forces probably plays a certain role in the mechanism of its therapeutic action in severe viral infections of man such as severe recurring ophthalmic herpes, genital herpes, Behçet's disease, Melkersson-Rosenthal syndrome and others.
Nikolaeva
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D000276:Adjuvants, Immunologic; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007113:Immunity, Innate / Q000187:drug effects; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D051379:Mice; D009285:Naphthoquinones / Q000627:therapeutic use*; D013997:Time Factors; D014777:Virus Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D007369:Interferon Inducers; D009285:Naphthoquinones; C011180:bonafton; D007372:Interferons
Izuchenie interferonindutsiruiushcheĭ i immunostimuliruiushcheĭ aktivnosti bonaftona v éksperimente.