Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist.
Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocked carrageenan-induced hyperalgesia, hyperthermia and edema. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.
Costello
A H
AH
Neurobiology and Anesthesiology Branch, National Institutes of Health, Bethesda, MD 20892.
Hargreaves
K M
KM
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007611:Aprotinin / Q000494:pharmacology; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D007610:Kallikreins / Q000037:antagonists & inhibitors; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D007611:Aprotinin; C053010:NPC 567; D007610:Kallikreins; D001920:Bradykinin