[Contents of serotonin and 5-hydroxyindoleacetic acid in the rabbit brain after long-term administration of lithium oxybutyrate].
Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in rat brain were analysed 24 hours after 7-, 15-, 29- days lithium hydroxybutyrate (LH) injections (10 mg/kg daily). After 7 days the drug reduced 5-HT in hypothalamus and 5-HIAA in the mid brain by 35%. After 15 days LH decreased 5-HT in striatum, hypothalamus by 32 and 17% and 5-HIAA in thalamus, hypothalamus by 28 and 44% respectively. After 29 days LH diminished 5-HT in striatum, hippocampus, amygdala by 24, 29 and 32% and 5-HIAA--in hypothalamus by 42%. The role of adaptative changes and stabilization processes in the central serotoninergic system in mechanism of LH psychotropic effects is discussed.
Saratikov
A S
AS
Fisanova
L L
LL
Zamoshchina
T A
TA
Sakharova
S A
SA
D000679:Amygdala / Q000032:analysis; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D007031:Hypothalamus / Q000032:analysis; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000032:analysis*; D013788:Thalamus / Q000032:analysis; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C022826:lithium hydroxybutyrate; D008094:Lithium
Soderzhanie serotonina i 5-oksiindoluksusnoĭ kisloty v mozge krolikovpri dlitel'nom naznachenii oksibutirata litiia.