[Cytogenetic effects of 9-(2-hydroxyethoxymethyl)guanine].
Mutageneous activity of a highly-efficient and low toxic antiherpes drug 9-(2-hydroxyethoxymethyl) guanine (Acyclovir) was first shown. The method for the detection of micronuclear polychromatic erythrocytes in mice bone marrow was used. A dose-dependent cytogenetic effect was noted in the dose range of acyclovir of 5-600 mg/kg. The results obtained permitted designation of this preparation to class "B" in accordance with the classification of potential mutagenic danger, adopted for the ready-made drug forms in the USSR. According to the type of cytotoxic effect on hemopoiesis, acyclovir may be referred to antimetabolites of nucleic acids.
Shobukhov
V M
VM
Iurchenko
V V
VV
D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D012156:Reticulocytes / Q000187:drug effects*; D013194:Staining and Labeling
D009153:Mutagens; D000212:Acyclovir
Tsitogeneticheskoe deĭstvie 9-(2-gidroksiétoksimetil) guanina.