Gamma-interferon induced human keratinocyte HLA-DR synthesis: the role of dermal activated T lymphocytes.
Experiments were performed to examine the hypothesis that the surface expression of HLA-DR by keratinocytes in certain disease states is conferred by the activity of gamma-interferon, derived from dermal activated T lymphocytes. In vivo studies revealed a spatial relationship between keratinocyte HLA-DR expression and activated T lymphocytes within the dermal inflammatory infiltrate. In vitro studies confirmed that gamma-interferon can induce keratinocyte synthesis of HLA-DR. These results suggest that, in vivo, gamma-interferon produced by activated T lymphocytes induces keratinocyte HLA-DR synthesis and expression.
Barker
J N
JN
Laboratory of Applied Dermatopathology, United Medical School, Guy's Hospital, London, U.K.
Navsaria
H A
HA
Leigh
I M
IM
MacDonald
D M
DM
D000328:Adult; D002478:Cells, Cultured; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000096:biosynthesis / Q000494:pharmacology*; D007633:Keratins / Q000276:immunology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000378:metabolism
D006684:HLA-DR Antigens; D007633:Keratins; D007371:Interferon-gamma