title: Glycolic acid and tryptophan effects on feed intake and hypothalamic indoleamines in chicks.
abstract: The effect of intraperitoneal injections of glycolic acid, glycine or tryptophan on feed intake and hypothalamic levels of 5-hydroxy-tryptamine (5-HT) and 5-hydroxy indole acetic acid (5-HIAA) was examined in chicks. Glycolic acid significantly depressed feed intake in a dose-dependent manner in comparison to saline or glycine, but only in birds injected with a level higher than 150 mg/kg body weight. The injection of glycolic acid or tryptophan but not glycine inhibited feed intake, and increased hypothalamic 5-HT and 5-HIAA 2 hr post-injection, as compared with saline injected controls. Blood plasma total lipids were elevated by all 3 compounds but plasma glucose was unaffected. The reduced feed intake obtained by injection of glycolic acid appears to result from an effect on the serotonergic system.
authors: Department of Poultry Science, University of Georgia, Athens 30602.
authors: Y
authors: Y
authors: Pinchasov
authors: B I
authors: BI
authors: Fancher
authors: W H
authors: WH
authors: Burke
authors: L S
authors: LS
authors: Jensen
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005998:Glycine / Q000494:pharmacology; D006016:Glycolates / Q000008:administration & dosage / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis* / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D012701:Serotonin / Q000032:analysis*; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D006016:Glycolates; C031149:glycolic acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D005998:Glycine