In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis.
The role of CD5+ lymphocytes in the recovery phase and on immunospecific protection against experimental allergic neuritis (EAN) was examined in Lewis rats by in vivo treatment with Ox19, a mouse anti-rat CD5 monoclonal antibody. Animals pretreated with the peripheral nerve basic protein P2 and thereby rendered resistant to the disease showed clinical signs of EAN after intraperitoneal (i.p.) Ox19 injection given at the same time as the rechallenge with neuritogenic doses of myelin in Freund's complete adjuvant. Non-pretreated rats recovered from signs of EAN developed a clinical relapse after i.p. Ox19 injections. Taken together, these data suggest an important regulatory role of the CD5 receptor in the immune response.
Strigård
K
K
Department of Neurology, Karolinska Institutet, Stockholm, Sweden.
Larsson
P
P
Holmdahl
R
R
Klareskog
L
L
Olsson
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000032:analysis; D000943:Antigens, Differentiation / Q000276:immunology*; D018956:CD5 Antigens; D005434:Flow Cytometry; D005620:Freund's Adjuvant / Q000008:administration & dosage; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000032:analysis; D009169:Mycobacterium tuberculosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000008:administration & dosage; D009444:Neuritis, Autoimmune, Experimental / Q000097:blood / Q000209:etiology / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D012008:Recurrence; D013154:Spleen / Q000032:analysis; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D018956:CD5 Antigens; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D005620:Freund's Adjuvant