title: Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-2-antichymotrypsin in patients with lung carcinoma.
abstract: Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-2-antichymotrypsin was evaluated in 26 patients with lung carcinoma. We observed an evident decrease in alpha-2-M and alpha-1-antitrypsin level and no differences between tested and control groups in alpha-1-antichymotrypsin concentration. The deficiency of protease inhibitors may be due to the increased level of protease activity in malignant cells. Infiltration of granulocytes near tumor and released enzymes from them may exhaust proteolytic inhibitory capacity, too. Increased protease activity is associated with transformation and uncontrolled proliferation, therefore antiproteases may be accepted as anticancerogenic factors. Further investigations are needed to bring us closer to understanding this question.
authors: Department of Haematological Diagnostics, Medical School, Białystok, Poland.
authors: M
authors: M
authors: Dabrowska
authors: J
authors: J
authors: Prokopowicz
authors: H
authors: H
authors: Kemona
authors: J
authors: J
authors: Kretowska
authors: S
authors: S
authors: Kiluk
authors: M
authors: M
authors: Gluszczak
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000514:alpha 1-Antichymotrypsin / Q000032:analysis* / Q000502:physiology; D000515:alpha 1-Antitrypsin / Q000032:analysis* / Q000502:physiology; D000511:alpha-Macroglobulins / Q000032:analysis* / Q000502:physiology
chemical_list: D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins