title: Paraoxon-induced desensitization and its reversal by tetrodotoxin.
abstract: 1. Paraoxon (10 microM for 20 min) induced a desensitization of the taenia caecum of the guinea-pig for contractions produced by a number of cholinomimetics. 2. Tetrodotoxin (0.3 microM) reversed the desensitization suggesting involvement of Na+ channels.
authors: School of Pharmacology, Victorian College of Pharmacy, Melbourne, Australia.
authors: A L
authors: AL
authors: Gardner
authors: L K
authors: LK
authors: Choo
authors: F
authors: F
authors: Mitchelson
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006168:Guinea Pigs; D007473:Ion Channels / Q000378:metabolism; D010261:Paraoxon / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology*
chemical_list: D007473:Ion Channels; D011759:Pyrrolidines; D010862:Pilocarpine; D013779:Tetrodotoxin; C004296:N-benzyl-3-pyrrolidylacetate methobromide; D002217:Carbachol; D012964:Sodium; D010261:Paraoxon