Effects of ipsapirone on the level of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in some regions of the rat brain.
Ipsapirone (TVX Q 7821), a compound with a high affinity for the 5-HT1A receptor-subtype, decreased by itself 5-HIAA level and reduced 5-HIAA accumulation after probenecid administration in the rat hypothalamus. The reduced 5-HIAA level and 5-HIAA/5-HT ratio after the 5-HT1A selective agonist 8-OH-DPAT was not antagonized by pretreatment with ipsapirone.
Gołembiowska
K
K
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
D006916:5-Hydroxytryptophan / Q000378:metabolism*; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011339:Probenecid / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D011743:Pyrimidines; D013764:Tetrahydronaphthalenes; D006897:Hydroxyindoleacetic Acid; C043077:ipsapirone; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D006916:5-Hydroxytryptophan; D011339:Probenecid