Preferential decay of passively acquired immunoglobulins recognizing shared gram-negative core antigens in neonatal swine.
Serum immunoglobulins of the IgG isotype recognizing common gram-negative cell core epitopes were serially measured by use of a direct ELISA on blood obtained from 10 neonatal swine. An R-mutant Escherichia coli (strain J5) was used as a plate antigen. Total serum IgG was measured by use of radial immunodiffusion. Half-lives of core antigen-specific IgG (6.81 days) and total serum IgG (14.85 days) were dramatically different (P less than 0.01).
Tyler
J W
JW
Department of Clinical Pathology, School of Veterinary Medicine University of California, Davis 95616.
Cullor
J S
JS
Douglas
V L
VL
Smith
W L
WL
Parker
K M
KM
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D000939:Epitopes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology*; D006207:Half-Life; D007116:Immunization, Passive / Q000662:veterinary*; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D013552:Swine / Q000276:immunology*
D000942:Antigens, Bacterial; D000939:Epitopes; D007074:Immunoglobulin G