Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon.
In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone.
Clauss
W
W
Institut für Veterinärphysiologie, Freie Universität Berlin, Federal Republic of Germany.
Dürr
J E
JE
Krattenmacher
R
R
Hörnicke
H
H
Van Driessche
W
W
D000450:Aldosterone / Q000097:blood / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm; D003106:Colon / Q000502:physiology*; D004594:Electrophysiology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D008871:Microvilli / Q000502:physiology; D011817:Rabbits; D012964:Sodium / Q000378:metabolism*; D013148:Spironolactone / Q000494:pharmacology
D007473:Ion Channels; D013148:Spironolactone; D000450:Aldosterone; D012964:Sodium