title: Enhanced erythrocyte aggregability in occlusive cerebrovascular disease.
abstract: We measured the rate of erythrocyte aggregation using our whole-blood aggregometer in 80 patients with occlusive cerebrovascular disease during the acute and chronic phases. We compared the data with values for 38 age-matched healthy controls. Mean +/- SD erythrocyte aggregability of the patients during both the acute phase (0.145 +/- 0.21/sec, n = 35) and the chronic phase (0.139 +/- 0.21/sec, n = 45) was higher than that in the controls (0.123 +/- 0.21/sec, n = 38; p less than 0.01). Erythrocyte aggregability was positively correlated with the plasma concentration of globulin and fibrinogen and inversely correlated with the albumin:globulin ratio. However, these correlations did not necessarily exclude the possibility that some unknown substance(s) released from ischemic tissue might enhance erythrocyte aggregability.
authors: Department of Neurology, Ashikaga Red Cross Hospital, Japan.
authors: N
authors: N
authors: Tanahashi
authors: F
authors: F
authors: Gotoh
authors: M
authors: M
authors: Tomita
authors: T
authors: T
authors: Shinohara
authors: Y
authors: Y
authors: Terayama
authors: B
authors: B
authors: Mihara
authors: K
authors: K
authors: Ohta
authors: M
authors: M
authors: Nara
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000510:Alpha-Globulins / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000097:blood*; D002908:Chronic Disease; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005916:Globulins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000510:Alpha-Globulins; D005916:Globulins; D012709:Serum Albumin; D005340:Fibrinogen