Genetic considerations in the design of a malaria vaccine.
Enormous progress has been made in recent years in understanding the molecular basis of the interaction of peptides, the major histocompatibility complex and the T-cell receptor. Considerable information must still be gathered before a malaria vaccine capable of protecting individuals in endemic areas is available. This review discusses studies pertaining to the search for T epitopes suitable for inclusion in a malaria vaccine in the light of current concepts of the recognition of peptides by T cells.
Rzepczyk
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D000818:Animals; D000917:Antibody Formation; D000939:Epitopes; D006801:Humans; D008285:Major Histocompatibility Complex; D008288:Malaria / Q000235:genetics / Q000517:prevention & control*; D010455:Peptides / Q000502:physiology*; D010963:Plasmodium falciparum / Q000254:growth & development; D013601:T-Lymphocytes / Q000502:physiology*; D014612:Vaccines; D014614:Vaccines, Synthetic
D000939:Epitopes; D010455:Peptides; D014612:Vaccines; D014614:Vaccines, Synthetic