title: Hereditary nonspherocytic hemolytic anemia in beagles.
abstract: Three Beagles with chronic anemia and reticulocytosis were studied. The dogs originated from a large breeding colony and appeared clinically normal with the exception of splenomegaly. The PCV ranged from 30 to 39% (normal, 46 to 56%), with reticulocyte indices of 2.3 to 9.9. Red blood cells were morphologically normal, and examination of marrow aspirates revealed erythroid hyperplasia. Shortened chromium-51 RBC life-spans (7.2 to 15.4 days in anemic dogs; 22.2 to 25.2 days in control dogs) documented a hemolytic anemia. Acquired causes of hemolytic anemia were ruled out. Red blood cells had normal glycolytic enzyme activities, no evidence of unstable or abnormal hemoglobin, and had altered osmotic fragility curves. The breeding of 2 anemic dogs resulted in offspring with anemia and reticulocytosis. Polyacrylamide gel electrophoresis revealed no abnormalities in RBC membrane cytoskeletal proteins in all anemic adult dogs and in 3 offspring.
authors: Department of Pathology, School of Medicine, University of Washington, Seattle 98195.
authors: L
authors: L
authors: Maggio-Price
authors: C L
authors: CL
authors: Emerson
authors: T R
authors: TR
authors: Hinds
authors: F F
authors: FF
authors: Vincenzi
authors: W R
authors: WR
authors: Hammond
mesh_terms: D000745:Anemia, Hemolytic, Congenital / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001947:Breeding; D004283:Dog Diseases / Q000097:blood / Q000235:genetics*; D004285:Dogs; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000032:analysis / Q000201:enzymology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D009996:Osmotic Fragility; D013194:Staining and Labeling
chemical_list: D006454:Hemoglobins; D008565:Membrane Proteins