Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.
Draetta
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G
Cold Spring Harbor Laboratory, New York 11724.
Piwnica-Worms
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H
Morrison
D
D
Druker
B
B
Roberts
T
T
Beach
D
D
D016203:CDC2 Protein Kinase; D002453:Cell Cycle; D006367:HeLa Cells; D008938:Mitosis; D010750:Phosphoproteins / Q000378:metabolism*; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src); D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D019000:Phosphotyrosine; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src); D016203:CDC2 Protein Kinase