In vitro action of insulin on erythrocyte sodium transport mechanisms: its possible role in the pathogenesis of arterial hypertension.
The effects of insulin on sodium and potassium metabolism have been well known for many years; clinical observation and laboratory experience showed different results about the insulin effect on the sodium-potassium pump. Moreover, studies about the insulin effect on the sodium-potassium cotransport are not available. Therefore, the effects of insulin on Na+,K+ pump and Na+,K+ cotransport were evaluated. Results show that insulin inhibits Na+,K+ pump, while Na+,K+ cotransport is markedly activated. The possible link between pathogenesis of arterial hypertension in hyperinsulinemic subjects and present data is examined.
Tedde
R
R
Institute of Clinica Medica Generale, University of Sassari, Italy.
Sechi
L A
LA
Marigliano
A
A
Scano
L
L
Pala
A
A
D000328:Adult; D001693:Biological Transport, Active / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood*
D007328:Insulin; D007473:Ion Channels; D012964:Sodium; D011188:Potassium