Does diffuse intimal thickening in human coronary artery act as a diffusion barrier to endothelium-derived relaxing factor?
We investigated the effect of intimal thickness in human coronary artery on the endothelium-dependent relaxation. Histamine (in the presence of cimetidine), substance P and A23187 potently relaxed arterial rings with intima thinner than 200 microns. However, those relaxations diminished progressively in the artery with intimal thickness of 200-400 microns, and disappeared at the thickness greater than 400 microns. These results suggest that diffuse intimal thickening greater than 200 microns may inhibit the diffusion of endothelium-derived relaxing factor.
Keitoku
M
M
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Okayama
H
H
Satoh
Y
Y
Maruyama
Y
Y
Takishima
T
T
D001685:Biological Factors / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D004058:Diffusion; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009569:Nitric Oxide; D013373:Substance P / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
D001685:Biological Factors; D009569:Nitric Oxide; D013373:Substance P; D000001:Calcimycin; D006632:Histamine