Expression of haematopoietic progenitor cell-associated antigen BI-3C5/CD34 in leukemia.
The expression of progenitor cell-associated antigen CD34, defined with monoclonal antibody BI-3C5, was investigated in cells from 109 patients with leukaemia. No reactivity was found in chronic leukaemias, whereas 31% of acute myelogenous leukaemia (AML) and most non-T, non-B acute lymphoblastic leukaemia (ALL) expressed CD34. Examples of BI-3C5+ AML included M1 and M2 FAB types only; all but one were myeloperoxidase positive. In combination with pan-myeloid markers, BI-3C5 is useful for identification of immature myeloid cells.
Batinić
D
D
Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre-Rebro, Zagreb, Yugoslavia.
Tindle
R
R
Boban
D
D
Tiefenbach
A
A
Rajić
L
L
Labar
B
B
Nemet
D
D
Boranić
M
M
D000328:Adult; D000911:Antibodies, Monoclonal; D018952:Antigens, CD34; D000943:Antigens, Differentiation / Q000096:biosynthesis*; D002648:Child; D006801:Humans; D007938:Leukemia / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D018952:Antigens, CD34; D000943:Antigens, Differentiation