Thyroid hormone response elements in pituitary genes.
Thyroid hormones regulate the transcription of a number of genes in the anterior pituitary gland. A thyroid hormone response element in the regulatory region of the rat growth hormone gene has previously been shown to mediate the effects of thyroid hormones on growth hormone gene transcription. The 5' flanking regions of the thyrotrophin alpha and beta subunit and prolactin genes have now been examined for the presence of sequences similar to this response element. Southern blotting reveals that no such sequences are present in the regions of the thyrotrophin subunit and prolactin genes examined, suggesting that the thyroid response elements of these genes differ from that of the rat growth hormone gene.
Ahlquist
J A
JA
Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, U.K.
Franklyn
J A
JA
Sheppard
M C
MC
Ramsden
D B
DB
D000818:Animals; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D015292:Glycoprotein Hormones, alpha Subunit / Q000235:genetics; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D015345:Oligonucleotide Probes; D010908:Pituitary Hormones, Anterior / Q000235:genetics*; D011388:Prolactin / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D013963:Thyroid Hormones / Q000502:physiology*; D013972:Thyrotropin / Q000235:genetics
D015292:Glycoprotein Hormones, alpha Subunit; D015345:Oligonucleotide Probes; D010908:Pituitary Hormones, Anterior; D013963:Thyroid Hormones; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D004247:DNA