title: Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.
abstract: Complementary DNAs were isolated and used to deduce the primary structures of the alpha 1 and alpha 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from rabbit skeletal muscle. The alpha 1 subunit, which contains putative binding sites for calcium antagonists, is a hydrophobic protein with a sequence that is consistent with multiple transmembrane domains and shows structural and sequence homology with other voltage-dependent ion channels. In contrast, the alpha 2 subunit is a hydrophilic protein without homology to other known protein sequences. Nucleic acid hybridization studies suggest that the alpha 1 and alpha 2 subunit mRNAs are expressed differentially in a tissue-specific manner and that there is a family of genes encoding additional calcium channel subtypes.
authors: Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037.
authors: S B
authors: SB
authors: Ellis
authors: M E
authors: ME
authors: Williams
authors: N R
authors: NR
authors: Ways
authors: R
authors: R
authors: Brenner
authors: A H
authors: AH
authors: Sharp
authors: A T
authors: AT
authors: Leung
authors: K P
authors: KP
authors: Campbell
authors: E
authors: E
authors: McKenna
authors: W J
authors: WJ
authors: Koch
authors: A
authors: A
authors: Hui
authors: A
authors: A
authors: Schwartz
authors: M M
authors: MM
authors: Harpold
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003001:Cloning, Molecular; D004247:DNA; D004262:DNA Restriction Enzymes; D004095:Dihydropyridines / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects; D008969:Molecular Sequence Data; D009928:Organ Specificity; D010449:Peptide Mapping; D012333:RNA, Messenger / Q000096:biosynthesis; D011817:Rabbits; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D007473:Ion Channels; D012333:RNA, Messenger; D004247:DNA; D004262:DNA Restriction Enzymes; D002118:Calcium