Serum gonadotropins in postmenopausal women after long-term verapamil treatment.
The effect of long-term verapamil treatment on serum gonadotropin levels was studied in 13 postmenopausal women aged 48-73 years given verapamil 160-320 mg daily for 2-8 months. Serum luteinizing hormone and follicle stimulating hormone concentrations were unchanged during verapamil treatment [7.1 (5.8:11.0) and 24 (21:26) micrograms/L before and 8.8 (5.1:9.1) and 25 (19:31) micrograms/L following verapamil]. This suggests that chronic calcium influx inhibition has no major influence on the release of gonadotropins from pituitary cells.
Hulthén
U L
UL
Department of Endocrinology, University of Lund, Malmö General Hospital, Sweden.
Katzman
P L
PL
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D014700:Verapamil / Q000009:adverse effects* / Q000627:therapeutic use
D006062:Gonadotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D014700:Verapamil