Serum levels of estrogens and of five 'steroid sensitive' proteins in early normal pregnancy.
Serum concentrations of sex hormone binding globulin (SHBG), pregnancy associated alpha 2-glycoprotein (alpha 2-PAG), caeruloplasmin (Cp), alpha 1-antitrypsin (alpha 1-At) and transferrin (Tf), unconjugated and total estrone, and unconjugated estradiol-17 beta were measured twice at a 4-5 week interval in 43 cases of early normal pregnancy (gestational weeks 6-19). Significant correlations between estrogen and protein levels in the total material were observed for all proteins except for Tf. However, within 2-week intervals of pregnancy, significant correlations were obtained only in certain intervals between estrogens on one hand and SHBG, Cp and alpha 1-At on the other. Significant correlations between rates of increase of estrogens and of proteins were obtained only at certain occasions for SHBG, Cp, Tf and alpha 1-At. The results indicate that, although estrogens may have a modulatory function in 'steroid-sensitive' protein synthesis, they are probably not the main physiological regulator.
Sparre
L S
LS
Department of Obstetrics and Gynaecology, Karolinska Institutet, Danderyd Hospital, Sweden.
Brundin
J
J
Carlström
A
A
von Schoultz
B
B
Carlström
K
K
D002570:Ceruloplasmin / Q000378:metabolism; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011257:Pregnancy Proteins / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D011257:Pregnancy Proteins; D012738:Sex Hormone-Binding Globulin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D004970:Estrone; D004958:Estradiol; D002570:Ceruloplasmin; D011266:Pregnancy-Associated Plasma Protein-A