Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
A modification of the polymerase chain reaction has been used to establish the fact that a collection of Staphylococcus aureus toxins are "superantigens," each of which interacts with the T-cell alpha beta receptor of human T cells by means of a specific set of V beta elements.
Choi
Y W
YW
Howard Hughes Medical Institute, Division of Basic Immunology, Denver, CO.
Kotzin
B
B
Herron
L
L
Callahan
J
J
Marrack
P
P
Kappler
J
J
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics* / Q000276:immunology; D001427:Bacterial Toxins / Q000276:immunology*; D001483:Base Sequence; D017252:CD3 Complex; D005796:Genes; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D000945:Antigens, Differentiation, T-Lymphocyte; D001427:Bacterial Toxins; D017252:CD3 Complex; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D012313:RNA