First experiences in application of RFLP analysis for carrier detection in preparation of prenatal diagnosis of hemophilia A in the GDR.
The application of the intragenic probe F8 e16-19 of factor VIII gene is reported for carrier detection in preparation of prenatal diagnosis of hemophilia A in a family at risk. The proband's mother is heterozygous for the Bcl I polymorphism and prenatal diagnosis can be offered to this family.
Herrmann
F H
FH
Institute of Medical Genetics, Ernst-Moritz-Arndt-University, Greifswald, GDR.
Kruse
T
T
Wehnert
M
M
Vogel
G
G
Wulff
K
K
D015342:DNA Probes; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D005859:Germany, East; D006467:Hemophilia A / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011296:Prenatal Diagnosis / Q000379:methods*
D015342:DNA Probes