[Monoclonal antibodies against the kidney and kidney neoplasms: potential diagnostic probes and therapy].
Monoclonal antibodies (MAb) raised against plasma membranes isolated from human kidney and renal cancer (CA) were capable of reacting with epitopes of either proximal or distal tubular antigens, also found to be excreted in urine of patients under pathological conditions. CA disclosed a microheterogenous distribution of antigens carrying proximal and distal tubule epitopes respectively. Some hybridoma produced MAb which were able to recognize epitopes strongly associated with CA.
Scherberich
J E
JE
Zentrum der Inneren Medizin, Universität Frankurt.
Fischer
P
P
Karich
H J
HJ
Schoeppe
W
W
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000652:urine; D000939:Epitopes / Q000276:immunology; D006801:Humans; D006825:Hybridomas; D007668:Kidney / Q000276:immunology*; D007680:Kidney Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000939:Epitopes
Monoklonale Antikörper gegen Nieren und Nierenkarzinome: potentielle diagnostische Sonden und Therapeutika.