Effect of a pineal indolamine, 5-methoxyindole-3-acetic acid, on the estrous cycle and reproductive organs of female Wistar albino rats.
It has been suggested that the pineal gland has a specific role in the control of cyclic sexual activity in rats. One or more of the compounds isolated from this gland have been considered to be possible anti-fertility agents. In this study, the effect of different doses of 5-methoxyindole-3-acetic acid (5-MIAA) on the estrous cycle and the reproductive organs of female rats was studied. Daily injections of either 100 or 200 micrograms of 5-MIAA significantly prolonged the estrous cycles of mature female rats. After injections of 5-MIAA, an increase in diestrous smears was observed; in addition, the animals had estrous cycles without proestrous phase. Following the injections of 200 micrograms of 5-MIAA, a significant increase in uterine weight, plasma 17 beta-estradiol level and in the number of follicles were observed, and after injections of 5-MIAA (50, 100, 200 micrograms) a medium level of plasma progesterone was obtained. Thus it is concluded that 5-MIAA has an effect on the ovulation process of female rats.
Ocal-Irez
T
T
Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine, University of Istanbul, Turkey.
Durmus
G
G
Sekerkiran
Y
Y
Peker
C
C
Uygur
G
G
D000818:Animals; D004958:Estradiol / Q000097:blood; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology* / Q000187:drug effects; D010870:Pineal Gland / Q000032:analysis* / Q000502:physiology; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000033:anatomy & histology* / Q000187:drug effects
C001736:5-methoxyindoleacetic acid; D011374:Progesterone; D004958:Estradiol; D006897:Hydroxyindoleacetic Acid