[Interaction of anemone toxin BgTX8 with the ion channels of isolated mammalian neurons].
Interaction between anemone toxin BgTX8 and sodium channels in isolated single neurons of rat sensory ganglia was studied by voltage-clamp and intracellular perfusion techniques. It was shown that BgTX8 in external and internal solutions induced a dose-dependent slowdown of inactivation kinetics. Dissociation constant for receptor-toxin complex was found to be 4.10(-6) mol/l.
Valeev
A E
AE
Dashkin
A N
AN
Fleites
A G
AG
Alcorta
L F
LF
Mas
R
R
D000818:Animals; D003064:Cnidarian Venoms / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism
D003064:Cnidarian Venoms; D007473:Ion Channels; C056274:anemone toxin BgTX8 (Bunodosoma granolifera); D012964:Sodium; D011188:Potassium
Vzaimodeĭstvie anemonotoksina BgTX8 s ionnymi kanalami izolirovannykh neĭronov mlekopitaiushchikh.