Correlates of amylase and lipase levels in chronic dialysis patients.
Serum lipase and amylase isoenzymes were measured in 44 chronic hemodialysis patients, 16 CAPD patients and 22 normal volunteers. The enzyme levels of the two patient groups were similar and were significantly higher than those of the volunteer group. The ratio of pancreatic to salivary amylase was similar in all three groups. Anuric patients in both dialysis groups had higher enzyme levels than those with residual urine output. Linear regression analysis was done to attempt to identify factors which were good predictors of enzyme levels. Although no such factors were found in the hemodialysis group, in the CAPD group there were significant correlations between the degree of azotemia and the magnitude of enzyme elevations. Further studies are needed to determine the relative importance of oversecretion and underexcretion in the genesis of the amylase and lipase elevations found in dialysis patients.
Caruana
R J
RJ
Department of Medicine, Medical College of Georgia, Augusta.
Altman
R
R
Fowler
B
B
Blansit
B
B
Chaudhary
B A
BA
Weinstein
R S
RS
D000681:Amylases / Q000097:blood*; D001002:Anuria / Q000201:enzymology / Q000628:therapy; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000628:therapy; D008049:Lipase / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis
D007527:Isoenzymes; D008049:Lipase; D000681:Amylases