Lesional keratinocytes express OKM5, Leu-8 and Leu-11b antigens in lichen planus.
Biopsy specimens of involved and uninvolved skin were studied in 16 patients with lichen planus using murine monoclonal antibodies against several cell surface markers of effector and/or accessory cells of the immune system. In contrast to uninvolved skin, keratinocytes were found to express HLA-DR, OKM5, Leu-8 and Leu-11b antigens in all biopsies from involved skin. We demonstrate here for the first time the in vivo expression of several effector and/or accessory cell markers on keratinocytes in lichen planus.
Simon
M
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Department of Dermatology, University of Erlangen-Nürnberg, FRG.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D018955:CD36 Antigens; D016827:CD8 Antigens; D000078404:Epidermal Cells; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007633:Keratins / Q000276:immunology*; D008010:Lichen Planus / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D018955:CD36 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D007633:Keratins