Liver cell rosettes: structural differences in cholestasis and hepatitis.
Cholestatic and hepatitic liver cell rosettes, gland-like formations found respectively in chronic cholestasis and in chronic active hepatitis, represent structural modifications of liver cell plates in response to injury. Differences in cytokeratin expression, ultrastructure and three-dimensional (3-D) configuration have been investigated. Cholestatic rosettes are considered to be a form of biliary metaplasia of hepatocytes, linking with newly-formed bile ductules in adjacent septa and probably providing some protection from injury caused by abnormal bile constituents. Hepatitis rosettes, by contrast, are a form of liver cell regeneration developing in isolated surviving hepatocytes or small groups of hepatocytes within areas of collapse.
Nagore
N
N
Department of Histopathology, Royal Free Hospital, School of Medicine, London, England.
Howe
S
S
Boxer
L
L
Scheuer
P J
PJ
D001648:Bile Canaliculi / Q000648:ultrastructure; D001706:Biopsy; D002779:Cholestasis / Q000473:pathology*; D006526:Hepatitis C / Q000473:pathology; D006521:Hepatitis, Chronic / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008105:Liver Cirrhosis, Biliary / Q000473:pathology*; D008115:Liver Regeneration; D008854:Microscopy, Electron
D007633:Keratins