Murine granulocyte colony-stimulating factor: actions on normal and leukemic cells.
Granulocyte colony-stimulating factor (G-CSF) is a strongly conserved glycoprotein which induces the survival, proliferation and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The actions of G-CSF are mediated through a small number of specific cellular receptors which are induced to internalize and accumulate within the cell after binding of G-CSF at 37 degrees C. G-CSF receptors can be lost from the cell surface not only by binding G-CSF, but indirectly by other factors including GM-CSF, Multi-CSF, bacterial lipopolysaccharides, chemotactic peptides and phorbol esters, depending on cell type. Possible relationships of these processes to the mechanism of action of G-CSF are discussed.
Nicola
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Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000473:pathology*
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor