[Double blind study of Histaglobin-Triplex in the treatment of pollinosis due to grasses].
The therapeutical effect of Histaglobin-Triplex (combination of histamine and human gammaglobulin) has been analysed in a double blind study of grasses pollinosis. The placebo was constituted of human gammaglobulins without histamine. 21 patients have received the active preparation and 19 the placebo. The treatment was partially pre-seasonal and seasonal. All the subjective and clinical parameters have shown an important therapeutical superiority of the active preparation against the placebo. In this first group, the consumption for other drugs was less than in the control group. The tolerance of the product was excellent. Among the biological parameters studied (cutaneous tests, IgE, specific RAST measured at the beginning and at the end of the study), only RAST seem to be favourably influenced by the active preparation.
Girard
J P
JP
D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D006632:Histamine / Q000627:therapeutic use*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D005719:gamma-Globulins / Q000627:therapeutic use*
D004338:Drug Combinations; D005719:gamma-Globulins; C002114:Histaglobin; D007073:Immunoglobulin E; D006632:Histamine
Etude en double insu de l'Histaglobine-Triplex dans le traitement de la pollinose aux graminées.