[Establishment of an animal model of intrauterine growth retardation (IUGR)].
This paper reports the establishment of animal model of IUGR by injecting Actinomycin to pregnant rats at 0.1 micrograms/g on the tenth, eleventh and twelfth day after pregnancy. The rats were divided into control, test A, B and C groups. The body weight of test A group rats was obviously lowered than the controls (P less than 0.01). The fetal weight, placental function and serum total proteins of A group rats were also markedly lowered (P less than 0.01). IUGR incidence in test A, B and C groups were 66.2%, 41.2% and 27.8%, respectively. It may be seen that establishment of animal model of IUGR by giving Actinomycin on the 10th day after pregnancy of the rat produced the best results and the most cases of IUGR.
Zhang
W Y
WY
D000818:Animals; D003609:Dactinomycin; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D003609:Dactinomycin