[Tumor-specific changes in the mitochondrial genome of oncocytomas].
Two astrocytomas, 5 colon carcinomas, 3 clear cell carcinomas of kidney, 5 renal oncocytomas and 1 oxyphile adenoma of thyroid were examined for mitochondrial DNA-alterations applying 5 different restriction enzymes (Alu I, Hae III, Hpa II, Rsa I, Hinf I). Only by applying Hinf I restriction enzyme digestion we were able to prove alterations of the mitochondrial DNA in oncocytomas (2 additional bands of about 55 or 35 base pairs). This was the first proof of mitochondrial DNA-alteration in a human tumor. The present sequence analyses of DNA-alteration will help to explain which importance is attached to the alterations regarding genesis of oncocytic tumors.
Seitz
G
G
Welter
C
C
Blin
N
N
Kovacs
G
G
Remberger
K
K
D000236:Adenoma / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length
D004272:DNA, Mitochondrial; D004273:DNA, Neoplasm
Tumor-spezifische Veränderung im Genom von Mitochondrien aus Onkozytomen.