[Mechanisms of disrupting DNA repair in human cells. IV. Interferon protects DNA of noninfected and chronically infected human cells from damage caused by cadmium chloride].
The protective activity of interferon on the cadmium chloride-treated human cells (Hep-2), infected chronically with meals virus and uninfected, was studied. It was found that cadmium chloride induced the formation of partially non-repairable DNA lesions. Decrease in cell repair activity was observed in the cells chronically infected with virus. Pretreatment of cells with interferon protected cell DNA from formation of DNA breaks and caused more effective resynthesis of DNA breaks.
Vasil'eva
I M
IM
Kolonina
I V
IV
Kusainova
K A
KA
Bogomolova
N N
NN
Zasukhina
G D
GD
D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008459:Measles virus / Q000302:isolation & purification; D009153:Mutagens; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000382:microbiology
D009153:Mutagens; D002104:Cadmium; D004247:DNA; D007372:Interferons; D019256:Cadmium Chloride
Mekhanizmy narusheniĭ reparatsii DNK v kletkakh chelovka. Soobshchenie IV. Interferon zashchishchaet DNK neinfitsirovannykh i khronicheski infitsirovannykh kletok cheloveka ot povrezhdeniĭ, vyzyvaemykh khloristym kadmiem.