Effect of substance P on catecholamine secretion from rat adrenal medulla in situ.
Splanchnic nerve stimulation caused a frequency-dependent increase in catecholamine (CA) secretion with a maximum at 10 Hz from adrenal medulla of WKY rats in situ. Substance P (SP(1-11)) had no effect on the basal output of CA. During nerve stimulation, however, SP(1-11) decreased only the adrenaline (A) secretion by 18% at 10 Hz and by 55% at 20 Hz (p less than 0.05), whereas the noradrenaline (NA) secretion remained unchanged. These results provide further evidence that SP(1-11) may modulate frequency-dependently the secretion of CA from adrenal medulla in situ.
Richter
R
R
Institute of Drug Research, Academy of Sciences of the GDR, Berlin.
Michael
N
N
Oehme
P
P
D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D000818:Animals; D004558:Electric Stimulation; D004837:Epinephrine / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011921:Rats, Inbred WKY; D012016:Reference Values; D013153:Splanchnic Nerves / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D009638:Norepinephrine; D004837:Epinephrine