A unique case of intravenous injection of fungal "pancreatic" enzymes causing shock and proteolysis of haemostatic proteins.
A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caused by bacteremia, an anaphylactic reaction, or by direct activation of humoral or cellular mediators by the fungal enzymes. A haemostatic disturbance, particularly a drop in plasminogen, was observed. In vitro, the fungal enzyme preparation stimulated elastase release from isolated neutrophils and eliminated plasmatic inhibitors and plasminogen in normal plasma and whole blood. Human neutrophil elastase complexed to alpha 1-antitrypsin was increased in the patient's plasma, while the levels of the complexes thrombin-antithrombinIII and plasmin-alpha 2-antiplasmin, indicating recent coagulation or fibrinolysis, respectively, were not elevated. Thus, an activation of the neutrophils with release of elastase might have contributed to the observed coagulation disturbances.
Seitz
R
R
Zentrum für Innere Medizin, Klinikum der Philipps Universität, Marburg, F.R.G.
Adler
G
G
Koop
I
I
Koop
H
H
Egbring
R
R
D000328:Adult; D000681:Amylases / Q000494:pharmacology; D000707:Anaphylaxis / Q000139:chemically induced*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced*; D001798:Blood Proteins / Q000032:analysis; D004338:Drug Combinations / Q000494:pharmacology; D010450:Endopeptidases / Q000494:pharmacology; D005656:Fungal Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008049:Lipase / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood; D010958:Plasminogen / Q000032:analysis; D011480:Protease Inhibitors / Q000032:analysis; D012651:Self Medication / Q000009:adverse effects*; D000515:alpha 1-Antitrypsin
D001798:Blood Proteins; D004338:Drug Combinations; D005656:Fungal Proteins; D005765:Gastrointestinal Agents; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; C059312:nortase; D010958:Plasminogen; D008049:Lipase; D000681:Amylases; D010450:Endopeptidases; D010196:Pancreatic Elastase