[Effect of substance P and its N-terminal fragment on the components of the normal microcirculatory system and under stress].
The biomicroscopy experiments showed that the substance P N-terminal fragment (SP1-4) is not as injurious as the SP1-11 for the rat mesentery. The SP1-4/SP1-11 activity ratio is 0.007 to 1 in case of microcirculation disturbances and venular permeability increase, and 0.0007 to 1 in case of the mast cells degranulation increase. Injection of SP1-11 (125 micrograms/kg) prior to the 5-hr immobilization, enhanced the disturbances in microcirculatory system induced by the stress. Injection of SP1-4 (53 micrograms/kg) led to sedative or narcotic effects in 50% of rats correlated with the normalizing terminal blood flow, venular permeability and mast cells secretory activity.
Gorizontova
M P
MP
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008642:Mesenteric Veins / Q000187:drug effects* / Q000503:physiopathology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013373:Substance P / Q000494:pharmacology*; D014680:Veins / Q000187:drug effects*; D014699:Venules / Q000187:drug effects* / Q000503:physiopathology
D010446:Peptide Fragments; D013373:Substance P; C042612:substance P (1-4)
Vliianie veshchestva P i ego N-kontsevogo fragmenta na komponenty mikrotsirkuliatornoĭ sistemy v norme i pri stresse.