Immunohistological study of captopril-induced late cutaneous eruptions.
Immunohistological study of dermal infiltrate from two pemphigus- and one captopril-induced lichenoid eruption showed the presence of a CD8 (T suppressor) infiltrate that resembled that found in skin eruptions induced by graft-versus-host disease. It is suggested that a T cell cytotoxic reaction occurs in the epidermis that might be triggered by captopril-induced modification of keratinocytic antigens.
Bretin
N
N
Department of Dermatology, Nantes, France.
Dreno
B
B
Bureau
B
B
Litoux
P
P
D000368:Aged; D000369:Aged, 80 and over; D002216:Captopril / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008010:Lichen Planus / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D010392:Pemphigus / Q000139:chemically induced* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism; D013997:Time Factors
D006684:HLA-DR Antigens; D007633:Keratins; D002216:Captopril