Levels of Met-enkephalin, Leu-enkephalin, substance P and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment.
Common marmosets were treated daily with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 7-9 mg/kg i.p.) for 25 days, and then kept out of drug for three months before biochemical measurements in various brain areas. This treatment induced a dramatic fall (-80%) in dopamine, homovanillic acid and dihydroxyphenylacetic acid levels in the putamen and caudate nucleus, and a significant but less pronounced reduction (less than or equal to 50%) in the levels of these compounds in the nucleus accumbens. In contrast, the concentrations of four neuropeptides: met-enkephalin, leu-enkephalin, substance P, and cholecystokinin, remained unaltered in all brain areas examined in MPTP-treated marmosets. Therefore the neuropeptide alterations previously reported in Parkinson's disease are probably not secondary to the severe lesion of dopaminergic neurones, but constitute another intrinsic feature of the disease.
Taquet
H
H
INSERM U.288, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Nomoto
M
M
Rose
S
S
Jenner
P
P
Javoy-Agid
F
F
Mauborgne
A
A
Benoliel
J J
JJ
Marsden
C D
CD
Legrand
J C
JC
Agid
Y
Y
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002143:Callitrichinae; D002766:Cholecystokinin / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D011725:Pyridines / Q000494:pharmacology*; D012016:Reference Values; D013373:Substance P / Q000378:metabolism*
D011725:Pyridines; D015102:3,4-Dihydroxyphenylacetic Acid; D013373:Substance P; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D002766:Cholecystokinin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D006719:Homovanillic Acid