[Long-term hypotensive effects of substance P on the stress induced hypertension of primates].
The Substance P (SP) level in blood is lower in hypertensive individuals than in normotensive ones. Intravenous application of SP leaves the normotensive blood pressure largely unaffected, but decreases the enhanced blood pressure. Further studies on the effect of SP (i.v. application of 2.5 micrograms/kg b.w.) were performed on 26 primates; the results were as follows: With normotensive primates SP no effect on blood pressure. Upon repeated chasing and subsequent immobilization (load) the animals developed an arterial hypertension. Under the same load, the animals failed to develop hypertension if they were treated with SP 1 h before. A load-induced hypertension could be interrupted by injection of SP even after 3 weeks following initial load; the after-controls one year later revealed normotensive blood pressure values. Application of SP with two other animal groups with a manifest hypertonus lowered the blood pressure only transitorily. It is concluded that i.v. application of SP can prevent the development of stress-induced hypertension and, with existing manifest hypertension, leads to reduced blood pressure only transitorily. An indirect action with peripheral site of attack is assumed.
Stechmesser
G
G
Zentralinstitut für Herz- und Kreislaufforschung, Akademie der Wissenschaften der DDR, Berlin-Buch.
Starzev
V G
VG
Oehme
P
P
Nitschkoff
S
S
Brattström
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000517:prevention & control*; D011323:Primates; D013312:Stress, Physiological / Q000150:complications*; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P
Hypotensive Langzeitwirkung von Substanz P auf eine stressinduzierte Hypertonie bei Primaten.