Changes in sensitivity to angiotensin II in platelets.
Our study on intracellular effects of angiotensin II in human platelets showed that: (1) angiotensin II increases intracellular free calcium in platelets via a receptor-operated mechanism and this increase is dose-dependent; (2) the effect on platelet intracellular free calcium depends on the extracellular calcium concentration; (3) ACE inhibition leads to an increased sensitivity of intracellular free calcium to angiotensin II but does not alter epinephrine-induced calcium increase; (4) nifedipine reduces the susceptibility of platelet intracellular free calcium for angiotensin II.
Haller
H
H
Department of Medicine, Klinikum Steglitz, Free University Berlin, F.R.G.
Lüdersdorf
M
M
Lenz
T
T
Distler
A
A
Philipp
T
T
D000284:Administration, Oral; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology; D012504:Saralasin / Q000494:pharmacology
D000804:Angiotensin II; D002216:Captopril; D012504:Saralasin; D009543:Nifedipine; D002118:Calcium