title: Efficacy and safety of rate responsive pacing in patients with coronary artery disease and angina pectoris.
abstract: The present study included 17 patients with angina pectoris and coronary artery disease in whom a rate responsive ventricular pacemaker (Medtronic Activitrax) had been implanted. All patients had an exclusively paced rhythm. Single blinded, random, cross-over treadmill tests in the rate responsive pacing mode (VVIR) and in the fixed-rate demand mode (VVI) were performed, with an interval of 4-6 weeks. Mean exercise duration increased by 25% during VVIR pacing. Maximal heart rate increased significantly during VVIR compared to VVI pacing (VVI = 74 +/- 2 bpm, VVIR = 116 +/- 8 bpm, P less than 0.001) as did the rate-pressure product (VVI = 10.850 +/- 1,124, VVIR = 16.628 +/- 2,110, P less than 0.001). Despite improved performance, the number of anginal attacks per week and the nitroglycerin consumption did not show a significant difference between the two pacing modes. It is concluded that rate responsive pacing is beneficial and safe in patients with angina pectoris and coronary artery disease.
authors: Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands.
authors: C C
authors: CC
authors: de Cock
authors: J H
authors: JH
authors: Panis
authors: M J
authors: MJ
authors: Van Eenige
authors: J P
authors: JP
authors: Roos
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D003327:Coronary Disease / Q000628:therapy*; D004526:Efficiency; D004869:Equipment Safety; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion