[Immunohistochemical and radiologic study of the accumulation of antibodies to the beta-1-MA antigen in human tumors transplanted into athymic mice].
Human tumours and tissues of nude mice were studied immunohistochemically using rabbit antibody to the beta-1-MA. Specific reaction was observed in colonic carcinomas, beta-1-MA was not found in other tumours. The specific reaction was found in intestinal epithelium of nude mice, and was absent in other tissues. 131I-labelled antibody to the beta-1-MA was intravenously administered to tumour-bearing nude mice. Specifically connected antibodies were revealed by immunohistochemical method in colonic carcinomas only. Radioimmunological investigation has shown accumulation of 131I-labelled antibodies to the beta-1-MA in colonic carcinomas.
Pugachev
K K
KK
Aleksandr
S K
SK
Fidler
L M
LM
Revazova
E S
ES
Shimbireva
I B
IB
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000276:immunology*; D007457:Iodine Radioisotopes; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology*; D013997:Time Factors; D014181:Transplantation Immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D000939:Epitopes; D007457:Iodine Radioisotopes
Immunogistokhimicheskoe i radiologicheskoe izuchenie nakopleniia antitel k antigenu beta-1-MA v opukholiakh cheloveka, transplantirovannykh bestimusnym mysham.