Anticancer potential of Viva-Natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine-accelerated AKR leukemia.
Viva-Natural, extracted from a dietary seaweed, containing a macrophage-activating polysaccharide, has been confirmed to be active against intraperitoneally implanted Lewis lung carcinoma (LLC) and spontaneous AKR T cell leukemia. The antitumor potential against LLC has been evaluated in comparison with standard synthetic immunomodulators such as pyran copolymer (MVE-2), isoprinosine, levamisole, and tilorone while manipulating the immune systems by immunosuppressive agents, cyclophosphamide (CY) and 2-chloroadenosine. The anti-LLC activity of Viva-Natural has been found to be superior to that of isoprinosine but inferior to that of MVE-2. LLC-enhancing effect of CY could be partially reserved by the subsequent administration of Viva-Natural or MVE-2 but not by isoprinosine. 2-Chloroadenosine, a specific macrophage inhibitor, abrogated the anti-LLC activity of Viva-Natural and isoprinosine but not the activity of MVE-2. Levamisole and tilorone showed no anti-LLC activity. Ethanol-precipitable fraction of water-soluble part of Viva-Natural (crude polysaccharide) demonstrated curative activity similar to that of MVE-2. Viva-Natural reversed the potentiation effect of ciclosporin on the development of leukemia in AKR mice at preleukemic stage.
Furusawa
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Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu.
Furusawa
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D000818:Animals; D000970:Antineoplastic Agents; D002277:Carcinoma / Q000276:immunology / Q000628:therapy; D003520:Cyclophosphamide / Q000494:pharmacology; D003524:Cyclosporins / Q000037:antagonists & inhibitors; D056890:Eukaryota; D007166:Immunosuppressive Agents; D007542:Inosine Pranobex / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000276:immunology / Q000628:therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
D000970:Antineoplastic Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D003520:Cyclophosphamide; D007542:Inosine Pranobex