[Effects of substance P and its fragments in physiological and pathological pain].
It has been shown that substance P and its fragments can produce under certain conditions an analgetic effect on both physiological and pathological pain (i.e. on pain syndrome of spinal origin). The data obtained give evidence that prolonged hypoalgesia is caused by the injection of substance P and its fragments to nucleus raphe dorsal--a structure of the antinociceptive system. This analgetic effect can be initiated by the activation of the antinociceptive system influenced by substance P and or its fragments.
Kryzhanovskiĭ
G N
GN
Igon'kina
S I
SI
Trubetskaia
V V
VV
Oeme
P
P
Binert
M
M
D000818:Animals; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D010147:Pain Measurement; D010446:Peptide Fragments / Q000008:administration & dosage*; D011903:Raphe Nuclei / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000008:administration & dosage*
D010446:Peptide Fragments; D013373:Substance P
Vliianie substantsii P i ee fragmentov na fiziologicheskuiu i patologicheskuiu bol'.