title: [Alpha fetoprotein in maternal serum in pregnancies with trisomy 18].
abstract: Maternal serum alpha-fetoprotein (MS-AFP) was assayed before amniocentesis in 2441 pregnancies of women age 35 or over and of women with prior birth of a child with a chromosome anomaly. Ten cases of trisomy 18 and 25 cases of trisomy 21 were detected. In trisomy 18 without neural tube defect we found MS-AFP levels significantly lower than in trisomy 21.
authors: Institut für Humangenetik, Klinikum der J.W. Goethe-Universität, Frankfurt.
authors: U
authors: U
authors: Dix
authors: M
authors: M
authors: Gams
authors: A
authors: A
authors: Grubisic
authors: J S
authors: JS
authors: Dericks-Tan
authors: U
authors: U
authors: Langenbeck
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins
vernacular_title: Alpha-Fetoprotein im mütterlichen Serum bei Schwangerschaften mit Trisomie 18.