Thrombosis promoting changes in chronic liver diseases.
Causes of haemorrhagic tendency in liver disorders have been widely studied. Deficiency of procoagulants is the best explanation for it. Not seldom a thrombotic tendency or even overt thrombosis occurs and may be satisfactorily explained. The level and function of two important natural anticoagulants, i.e. of antithrombin III and protein C is markedly reduced, first in liver cirrhosis. Heparin cofactor activity of AT III and/or heparin cofactor II may be especially diminished. The hypercoagulable state resulting from these changes may be further aggravated by a so-called hyper-adhesive state which is the consequence of the sustained high level of plasmatic vWFAg associated with liver cirrhosis. Altered haemostatic balance needs individual laboratory evaluation.
Rák
K
K
Second Department of Medicine, University Medical School Debrecen, Hungary.
D000328:Adult; D000941:Antigens / Q000032:analysis*; D002908:Chronic Disease; D006521:Hepatitis, Chronic / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications*; D013927:Thrombosis / Q000209:etiology*; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; C029417:Von Willebrand antigen; D014841:von Willebrand Factor