[Monoclonal gammopathy in HIV infection].
A lambda-light chain-IgA plasmocytoma, accompanied by a changing clinical picture of fever, nocturnal perspirations and weight loss, developed in a 46-year-old homosexual male with AIDS, stage IV (classification according to the Centers for Disease Control). He had been suffering from recurrent Salmonella septicaemia. Serum protein electrophoresis demonstrated marked elevation of the beta- and gamma-fractions (44% and 24%, respectively). There were 15% plasma cells in the differential blood count and in the bone marrow smear. Immunoelectrophoresis demonstrated free lambda-light chains. The IgA concentration in cerebrospinal fluid was raised to 202 mg/l, and there was an IgA paraproteinaemia. The patient died during a recurrence of the Salmonella septicaemia from septic cardiovascular failure.
Löhr
H F
HF
I. Medizinische Klinik und Poliklinik der Universität Mainz.
Ramadori
G
G
Mayet
W J
WJ
Hess
G
G
Meyer zum Büschenfelde
K H
KH
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D001609:Beta-Globulins / Q000032:analysis / Q000134:cerebrospinal fluid; D001772:Blood Cell Count; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000032:analysis / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D010265:Paraproteinemias / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D010950:Plasma Cells; D005719:gamma-Globulins / Q000032:analysis / Q000134:cerebrospinal fluid
D001609:Beta-Globulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D005719:gamma-Globulins
Monoklonale Gammopathie bei HIV-Infektion.