title: Heparin and bleeding: an association with lipase release.
abstract: The effects of four sulphated polysaccharides on bleeding time and lipase release in rabbits have been compared. Unfractionated heparin (UFH) and pentosan polysulphate both gave significant prolongation of bleeding times and high lipase release. Low molecular weight heparin had reduced effects on bleeding time and lipase release, while dermatan sulphate had no influence on either parameter. There was a highly significant correlation (r = 0.97) between these two measurements. These results suggest that the same structural features influence both the haemorrhagic and lipase-releasing properties of sulphated polysaccharides.
authors: National Institute for Biological Standards and Control, London, UK.
authors: T W
authors: TW
authors: Barrowcliffe
authors: R E
authors: RE
authors: Merton
authors: E
authors: E
authors: Gray
authors: D P
authors: DP
authors: Thomas
mesh_terms: D000818:Animals; D001760:Bleeding Time; D006470:Hemorrhage / Q000139:chemically induced* / Q000201:enzymology; D006493:Heparin / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology; D008049:Lipase / Q000378:metabolism*; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D006495:Heparin, Low-Molecular-Weight; D010426:Pentosan Sulfuric Polyester; D006493:Heparin; D008049:Lipase