title: Cytochemical studies in the blastic transformation of chronic granulocytic leukaemia.
abstract: The cytochemical features of blast cells were studied in 45 patients with blastic phase of chronic granulocytic leukaemia. Various degrees of Sudan black B positivity was characteristic of myeloblastic transformation (23 patients), while in the medullary blast cells of nine patients with myelomonocytic transformation the alpha-naphthyl-acetate esterase showed intensive activity. In two cases the demonstrability of beta-thromboglobulin and factor VIII-related antigen in blast cells showing otherwise PAS, acid phosphatase and alpha-naphthyl-acetate esterase activity referred to megakaryocytic transformation. In six patients with lymphoid blast crisis proliferation of the Sudan negative blast cells with different granular PAS, acid phosphatase and/or beta-glucuronidase positivity was demonstrated. In five cases the cytochemical findings of leukaemic cells indicated biphenotypic and mixed transformation, respectively.
authors: Department of Medicine, University Medical School, Debrecen, Hungary.
authors: B
authors: B
authors: Telek
authors: A
authors: A
authors: Kiss
authors: K
authors: K
authors: Pecze
authors: K
authors: K
authors: Rák
mesh_terms: D001752:Blast Crisis; D006651:Histocytochemistry; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*