[Monoclonal anti-AFP immunoscintigraphy of human hepatocellular carcinoma. Influence of biological, anatomical and vascular factors].
The actual interest of immunoscintigraphy for the detection of alphafetoprotein-producing liver tumors was investigated by both visual examination and quantitative analysis in 61 patients with either hepatocellular carcinoma (39 patients, group I), secondary liver cancer (11 patients, group II), or non tumoral liver (9 cirrhosis, 2 healthy liver, group III): All patients received injections of 123I-anti-alphafoetoprotein monoclonal antibodies and planar scans were performed after 28 hours. Only 18 out of 39 hepatocellular carcinoma-bearing patients had a positive scan (46 p. 100). Such a moderate sensibility was due to a striking inhibitory influence of cirrhosis: the positivity rate was 6/24 and 12/15 respectively when hepatocellular carcinoma was and was not associated with cirrhosis (p less than 0.01). Specificity was also moderate (55 p. 100) for detection of hepatocellular carcinoma in tumor-bearing patients (group I and II). In the absence of cirrhosis, the intensity of the tumoral uptake was highly correlated with high serum alphafoetoprotein level (p less than 0.001) and tumor arterial hypervascularization (p less than 0.01). Anti-alphafoetoprotein monoclonal antibody uptake by the extratumoral liver was found to be very specific of hepatocellular carcinoma since it was high in 23 out of 39 patients of group I but in only 1 out of 22 in groups II and III (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Duclos
B
B
Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, CHU Hautepierre, Strasbourg.
Demangeat
J L
JL
Manil
L
L
Chamouard
P
P
Baumann
R
R
Demangeat
C
C
Bruno
B
B
Jaeck
D
D
Constantinesco
A
A
Weill
J P
JP
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000276:immunology / Q000556:secondary; D004067:Digestive System Neoplasms / Q000276:immunology / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008722:Methods; D008875:Middle Aged; D011877:Radionuclide Imaging; D000509:alpha-Fetoproteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D000509:alpha-Fetoproteins
Immunoscintigraphie monoclonale anti-AFP du carcinome hépatocellulaire humain. Influence des facteurs biologiques, anatomiques et vasculaires.