A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.
Stamenkovic
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Department of Genetics, Harvard Medical School, Boston, MA.
Clark
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EA
Seed
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B
D000595:Amino Acid Sequence; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics*; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D001685:Biological Factors / Q000494:pharmacology; D019013:CD40 Antigens; D002277:Carcinoma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D016207:Cytokines; D005786:Gene Expression Regulation; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D009154:Mutation; D009414:Nerve Growth Factors / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics*; D017475:Receptors, Nerve Growth Factor; D012689:Sequence Homology, Nucleic Acid
D000944:Antigens, Differentiation, B-Lymphocyte; D001685:Biological Factors; D019013:CD40 Antigens; D016207:Cytokines; D006684:HLA-DR Antigens; D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor