title: Gamma/delta lineage relationship within a consecutive series of human precursor T-cell neoplasms.
abstract: We analyzed the gene rearrangements associated with the newly described delta T-cell receptor (TCR) gene from a series of 19 consecutive precursor T-cell (lymphoblastic) neoplasms that represent discrete stages surrounding the TCR gene rearrangement process. Significantly, the delta TCR gene showed rearrangement in most (13 of 19) of these T cells, and in addition it was rearranged in two cells displaying no rearrangement for any other TCR gene. Our survey showed three types of delta gene rearrangements associated with cell-surface TCR expression that presumably represent usage of three V delta genes. This analysis demonstrates (1) a major subclass of human precursor T-cell neoplasms belonging to the gamma/delta T-cell receptor-rearranging subtype; (2) a narrow repertoire of human V delta gene usage; and (3) the utility of delta gene rearrangements as a diagnostic clonal marker in precursor T lymphoblastic neoplasms.
authors: Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
authors: J P
authors: JP
authors: de Villartay
authors: A B
authors: AB
authors: Pullman
authors: R
authors: R
authors: Andrade
authors: E
authors: E
authors: Tschachler
authors: O
authors: O
authors: Colamenici
authors: L
authors: L
authors: Neckers
authors: D I
authors: DI
authors: Cohen
authors: J
authors: J
authors: Cossman
mesh_terms: D000595:Amino Acid Sequence; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D001483:Base Sequence; D015139:Blotting, Southern; D017252:CD3 Complex; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D002454:Cell Differentiation; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
chemical_list: D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D015342:DNA Probes; D004273:DNA, Neoplasm; D011948:Receptors, Antigen, T-Cell