Measurement of prothrombin mRNA during gestation and early neonatal development.
Prothrombin levels in the fetal and newborn lamb follow a gestational age-related pattern of development. The changes in activity are reflected by similar changes in prothrombin antigen concentration. Our investigations indicate that these changes in prothrombin antigen and activity levels are paralleled by changes in the levels of prothrombin messenger RNA present in liver samples from fetuses of various gestational ages.
Kisker
C T
CT
University of Iowa Hospitals and Clinics, Department of Pediatrics, Iowa City 52242.
Perlman
S
S
Bohlken
D
D
Wicklund
B
B
D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D011247:Pregnancy; D011516:Prothrombin / Q000032:analysis / Q000235:genetics*; D012313:RNA; D015347:RNA Probes; D016372:RNA, Antisense; D012333:RNA, Messenger / Q000032:analysis*; D012756:Sheep; D014813:Vitamin K Deficiency / Q000097:blood
D015347:RNA Probes; D016372:RNA, Antisense; D012333:RNA, Messenger; D012313:RNA; D011516:Prothrombin