Subsensitivity to substance P in SART-stressed mice.
The sensitivity of SART-stressed (repeated cold-stressed) mice to substance P (SP) was studied. The behavioral responses to intrathecal SP in the stressed mice were less marked than those in non-stressed mice. The 50% effective dose of SP, however, did not differ between the 2 groups. Also, the antagonistic effect of intrathecal [D-Pro2, D-Trp7,9]-substance P against SP was not different. These results suggest that SART-stressed mice are subsensitive to exogenous SP and that the number but not the affinity of SP receptors may be altered.
Hata
T
T
Department of Pharmacology, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.
Itoh
E
E
Oyama
R
R
Kawabata
A
A
Kita
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003080:Cold Temperature / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects; D013223:Statistics as Topic; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D013373:Substance P