Proteases and antiproteases related to the coagulation system in plasma and ascites. Prediction of coagulation disorder in ascites retransfusion.
To improve the ability to predict the occurrence of coagulation disorders in ascites retransfusion and, in addition, to better define the nature of the coagulation disorder, several proteases and antiproteases were analyzed in ascites and plasma before ascites retransfusion in 17 patients. Plasminogen, alpha 2-antiplasmin, antithrombin III, and fibrin(ogen) degradation products in ascites were significantly altered in patients who later developed abnormal coagulation as compared to those who did not. Only plasminogen and alpha 2-antiplasmin in ascites achieved a sufficient predictive value for the occurrence of coagulation abnormalities. The pattern of the coagulation abnormalities observed strongly suggests fibrinolysis induced by the infusion of plasminogen activators as the cause of the coagulation disorder in ascites retransfusion procedures.
Schölmerich
J
J
Department of Internal Medicine, University of Freiburg, F.R.G.
Zimmermann
U
U
Köttgen
E
E
Volk
B A
BA
Hasler
C
C
Wilms
H
H
Costabel
U
U
Gerok
W
W
D000990:Antithrombin III / Q000032:analysis; D001201:Ascites; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D010447:Peptide Hydrolases / Q000032:analysis* / Q000097:blood; D010958:Plasminogen / Q000032:analysis; D011480:Protease Inhibitors / Q000032:analysis* / Q000097:blood; D000979:alpha-2-Antiplasmin / Q000032:analysis
D005338:Fibrin Fibrinogen Degradation Products; D011480:Protease Inhibitors; D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D010958:Plasminogen; D010447:Peptide Hydrolases