title: The mycobacterial 65 kD heat-shock protein and autoimmune arthritis.
abstract: Arthritis - induced experimentally in rats by immunization with mycobacteria has been shown to depend on specific T cell recognition of an epitope present on the mycobacterial 65-kD heat-shock protein. This particular epitope has been observed to have a structural mimicry with a cartilage-associated molecule present in the joints. Since the bacterial heat-shock proteins and the cartilage-associated molecules are of a conserved nature, one might infer from the experimental model that in humans similar mimicry could play a role in the initiation of autoimmune arthritis. Recent findings from the analysis of immunological reactivity to the 65-kD in rheumatoid arthritis patients seem to support such a role for the mycobacterial 65-kD heat-shock protein in human disease.
authors: Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors: W
authors: W
authors: van Eden
authors: E J
authors: EJ
authors: Hogervorst
authors: R
authors: R
authors: van der Zee
authors: J D
authors: JD
authors: van Embden
authors: E J
authors: EJ
authors: Hensen
authors: I R
authors: IR
authors: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002358:Cartilage, Articular / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
chemical_list: D000939:Epitopes; D006360:Heat-Shock Proteins; D011948:Receptors, Antigen, T-Cell