title: De- and regeneration of axons after minor lesions in the rat sciatic nerve. Effects of microneurography electrode penetrations.
abstract: The structural effects of microneurography electrode penetrations were examined in the rat sciatic nerve. Such penetrations always produced restricted peri- and endoneurial lesions, resulting in degeneration of myelinated and unmyelinated axons, as well as in demyelination. The regenerative response was vigorous, and the regenerating axons usually formed a separate region of fascicle. However, restitution was not complete after 9 weeks survival, and in some cases not even after 16 weeks.
authors: Department of Anatomy, Karolinska Institutet, P.O.B. 60400, S-104 01 Stockholm, Sweden.
authors: K
authors: K
authors: Fried
authors: J
authors: J
authors: Frisén
authors: M
authors: M
authors: Mozart
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D008839:Microelectrodes; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology*; D013373:Substance P / Q000378:metabolism; D013997:Time Factors
chemical_list: D013373:Substance P