title: Elevated tumor markers in hemodialysis patients.
abstract: The incidence of elevated tumor markers without clinical signs of malignant disease was examined in 93 patients between the age of 29 and 79 years and on chronic dialysis for 3-240 months. Tissue polypeptide antigen was found to be elevated in 92.5%, carcinoembryonic antigen in 29.8, and alpha-fetoprotein in 6.5%. High levels of tissue polypeptide antigen were accompanied by high levels of beta 2-microglobulin (p less than 0.005). This indicates that tumor markers, and tissue polypeptide antigen in particular, may be unreliable for monitoring malignant disease in patients on hemodialysis.
authors: Abteilungen für Allgemeine Innere Medizin und Nephrologie, Klinikum Steglitz, Freie Universität Berlin.
authors: G
authors: G
authors: Walz
authors: U
authors: U
authors: Kunzendorf
authors: F
authors: F
authors: Keller
authors: R
authors: R
authors: Fitzner
authors: G
authors: G
authors: Offermann
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D006435:Renal Dialysis; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010455:Peptides; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins; D001613:beta 2-Microglobulin