Effect of enterosorption on animal lifespan.
Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.
Frolkis
V V
VV
Institute of Gerontology AMS USSR.
Nikolaev
V G
VG
Paramonova
G I
GI
Shchorbitskaya
E V
EV
Bogatskaya
L N
LN
Stupina
A S
AS
Kovtun
A I
AI
Sabko
V E
VE
Shaposhnikov
V M
VM
Muradian
K K
KK
D000375:Aging / Q000187:drug effects; D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008136:Longevity / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000648:ultrastructure; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
C029814:SKN hemosorbents; D002606:Charcoal; D012313:RNA