title: Vaso-occlusive retinopathy associated with antiphospholipid antibodies (lupus anticoagulant retinopathy).
abstract: The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain.
authors: Scheie Eye Institute, University of Pennsylvania, Philadelphia.
authors: R C
authors: RC
authors: Kleiner
authors: L V
authors: LV
authors: Najarian
authors: S
authors: S
authors: Schatten
authors: D A
authors: DA
authors: Jabs
authors: A
authors: A
authors: Patz
authors: H J
authors: HJ
authors: Kaplan
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000009:adverse effects / Q000032:analysis / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005451:Fluorescein Angiography; D006801:Humans; D008028:Light Coagulation; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012164:Retinal Diseases / Q000473:pathology / Q000628:therapy; D012171:Retinal Vessels / Q000473:pathology*; D014792:Visual Acuity
chemical_list: D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D011241:Prednisone