[Autoradiographic research on RNA biosynthesis in renal tissue in the early period of corrosive sublimate-induced necronephrosis].
Study of 3H-uridine autoradiographs in semithin methacrylate renal sections of white rats showed pronounced decrease of uridine mark in all cellular types of renal tissue following 24 hours after the administration of 0.5 mg corrosive sublimate per 100 g bw. The period was marked by the development of anuria in animals. 48 hours later increase of uridine mark level in renal cortical substance was observed. Epithelial cells being contiguous with necrosed zone of non- and partially damaged but kept-alive urinary small canals became hypertrophic and synthesized RNA actively preceding their mitotic division.
Andreev
V P
VP
Pal'tsyn
A A
AA
D000818:Animals; D001345:Autoradiography; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D009336:Necrosis; D009401:Nephrosis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D012313:RNA / Q000096:biosynthesis* / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D008627:Mercuric Chloride; D012313:RNA
Avtoradiograficheskoe issledovanie biosinteza RNK v pochechnoĭ tkani v ranniĭ period sulemovogo nekronefroza.