Immunocytochemical localization of carcinoembryonic antigen in cerebrospinal fluid with metastatic carcinoma of the stomach: report of four cases.
A study was undertaken to evaluate the cellular findings of gastric carcinoma in cerebrospinal fluid (CSF). Immunocytochemical localization of carcinoembryonic antigen (CEA) was performed on four cases of metastatic gastric carcinoma cells in CSF samples. A positive peroxidase-antiperoxidase (PAP) reaction was obtained in all cases, with intense staining for CEA in the CSF samples as well as in the paraffin-embedded tissue sections from the primary gastric tumors. Cellular morphology and the results of immunoperoxidase staining can be studied simultaneously. We believe that the PAP method for CEA increases diagnostic accuracy of cytology in the CSF.
Iwa
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N
Department of Pathology, National Cardiovascular Center, Osaka, Japan.
Yutani
C
C
Kobayashi
T K
TK
D000368:Aged; D002272:Carcinoembryonic Antigen / Q000134:cerebrospinal fluid*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000556:secondary*; D008875:Middle Aged; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000134:cerebrospinal fluid / Q000473:pathology*
D002272:Carcinoembryonic Antigen