title: [Comparative characteristics of the membrane mechanisms of the action of fenamine and its derivatives on the ion channels of isolated mollusk neurons].
abstract: Phenamine (10(-12)-10(-5) M/l) increased by 20-60 per cent the input (sodium and calcium) currents (Iin), the output slow potassium (Ikm) and fast potassium (Ikb) ones, and decreased the currents in higher concentrations. The volt-ampere characteristics of the membrane (VAC) and the curves of stationary inactivation (CSI) shifted along the potentials axis. The phenamine analogue IEM 1365 only decreased the currents leaving the VAC and CSI unaltered. Another analogue IEM 1370 only decreased the Iin whereas VAC and CSI also shifted along the potentials axis. The ion channels seem to be blocked in a decrease of the currents and the membrane surface potential induced with fixed charges seems to change.
authors: A I
authors: AI
authors: Vislobokov
authors: V V
authors: VV
authors: Mantsev
authors: V V
authors: VV
authors: Marenichev
authors: M A
authors: MA
authors: Dumpis
authors: N I
authors: NI
authors: Kudriashova
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008195:Lymnaea / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion / Q000379:methods
chemical_list: D000662:Amphetamines; D007473:Ion Channels; C062926:IEM 1365; C062927:IEM 1370; D000661:Amphetamine
vernacular_title: Sravnitel'naia kharakteristika membrannykh mekhanizmov deĭstviia fenamina i ego proizvodnykh na ionnye kanaly izolirovannykh neĭronov molliuskov.