Serum and urinary prostatic inhibin-like peptide in benign prostatic hyperplasia and carcinoma of prostate.
The levels of immunoreactive prostatic inhibin-like peptide (PIP), having follicle-stimulating hormone suppressing properties, were estimated in the sera and urine samples of patients with benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) as compared to age-matched controls. Significantly elevated serum PIP levels in BPH (107.8 +/- 19 ng/ml) and PC (88.7 +/- 9 ng/ml) patients were observed as compared to those in control men (10.2 +/- 1 ng/ml). Unlike serum, in urine high levels of PIP in BPH (294 +/- 49 micrograms/24 h) and extremely low levels in PC (23.6 +/- 5 micrograms/24 h) patients were seen as compared to control values (137.6 +/- 10 micrograms/24 h). Furthermore, striking differences were observed between the urinary PIP levels of BPH and PC patients. The results of the present investigation thus indicate the possible use of urinary PIP as a biological marker for prostate cancer.
Teni
T R
TR
Cancer Research Institute, Parel, Bombay, India.
Sheth
A R
AR
Kamath
M R
MR
Sheth
N A
NA
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007265:Inhibins / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000652:urine; D011471:Prostatic Neoplasms / Q000097:blood* / Q000652:urine; D011863:Radioimmunoassay
D014408:Biomarkers, Tumor; D007265:Inhibins