title: Effects of verapamil and BAY K 8644 on the hypoxic contraction of the isolated human pulmonary artery.
abstract: To examine the effect of hypoxia on the human pulmonary artery (HPA), HPA segments (2 mm, o.d.) were suspended and changes in isometric force with hypoxia (PO2 = 44 +/- 3 mmHg, mean +/- S.E.) were measured. HPA contracted with hypoxia and the tension developed with 15 min of hypoxia was 127 +/- 36 (mean +/- S.E.) mg. Verapamil at 47 +/- 10% 10(-6) M inhibited and 10(-6) M BAY K 8644 enhanced the hypoxic response by (p less than 0.01) and 396 +/- 106% (p less than 0.05), respectively, compared with preceding values. These results show that activation of voltage-dependent Ca2+ channels also plays an important role in the mechanism of hypoxic pulmonary vasoconstriction in man.
authors: First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors: M
authors: M
authors: Ohe
authors: M
authors: M
authors: Ogata
authors: K
authors: K
authors: Shirato
authors: T
authors: T
authors: Takishima
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010101:Oxygen Consumption; D011651:Pulmonary Artery / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D014700:Verapamil