Localization of tissue copper in mouse mammary tumors.
The purpose of this study was to determine the copper deposition and localization during the evolution of two murine mammary adenocarcinomas. In the normal tissue, the copper was located within the cytoplasm, whereas it was intra- and perinuclear in the tumors. The more angiogenic and metastatic tumor showed the higher percentage of copper-positive cells. In the tumor, copper deposits correlated well with its angiogenic and metastatic ability, but additional factors would be required for the process to be induced.
Fuchs
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AG
Departamento de Investigaciones, Instituto de Oncología Angel H. Roffo, Buenos Aires, Argentina.
de Lustig
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ES
D000230:Adenocarcinoma / Q000032:analysis* / Q000098:blood supply; D000818:Animals; D003300:Copper / Q000032:analysis*; D006651:Histocytochemistry; D008321:Mammary Glands, Animal / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000032:analysis* / Q000098:blood supply; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic
D003300:Copper