The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.
Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomyelitis (CREAE). It was found that class II MHC antigens, fibrin and fibronectin were present in normal blood vessels and at high levels in lesions from animals at all stages of the disease. The possible immunological roles of these antigens suggest their participation in the initiation and maintenance of disease state.
Butter
C
C
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, London, U.K.
Healey
D G
DG
Agha
N
N
Wilcox
C E
CE
Antoniou
A V
AV
Turk
J L
JL
D000818:Animals; D000911:Antibodies, Monoclonal; D001808:Blood Vessels / Q000032:analysis; D002908:Chronic Disease; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005337:Fibrin / Q000032:analysis*; D005353:Fibronectins / Q000032:analysis*; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007158:Immunologic Techniques; D008854:Microscopy, Electron; D012008:Recurrence; D013116:Spinal Cord / Q000032:analysis* / Q000098:blood supply / Q000473:pathology; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D005353:Fibronectins; D000949:Histocompatibility Antigens Class II; D005337:Fibrin