title: Substance P binding sites in the nucleus tractus solitarius of the cat.
abstract: Substance P binding sites in the nucleus tractus solitarius were visualized with receptor autoradiography using Bolton-Hunter [125I]substance P. Substance P binding sites were found to have distinct patterns within the cat nucleus tractus solitarius. The majority of substance P binding sites were present in the medial, intermediate and the peripheral rim of the parvocellular subdivisions. Lower amounts of substance P binding sites were present in the commissural, ventrolateral, interstitial and dorsolateral subdivisions. No substance P binding sites were present in the central region of the parvocellular subdivision or the solitary tract. The localization of substance P binding sites in the nucleus tractus solitarius is very similar to the patterns of substance P immunoreactive fibers previously described for this region. Results of this study add further support for a functional role of substance P in synaptic circuits of the nucleus tractus solitarius.
authors: Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536.
authors: B E
authors: BE
authors: Maley
authors: C A
authors: CA
authors: Sasek
authors: V S
authors: VS
authors: Seybold
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods; D002415:Cats; D007457:Iodine Radioisotopes; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000378:metabolism*; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P