title: Interstitial pneumonitis in allogeneic bone marrow transplantation: a report from the Japanese BMT Study Group.
abstract: One hundred and four patients with acute leukemia treated by allogeneic bone marrow transplantation in Japan were analysed for the incidence of interstitial pneumonitis (IP). Thirty-six (35%) of 104 marrow graft recipients developed IP. Cytomegalovirus (CMV) was the most frequent organism (61%). Using multivariate analysis, remission at transplant (P = 0.0001) and use of cyclosporin A to prevent graft-versus-host disease (P = 0.0363) were found to be significant factors associated with a decreased incidence of IP. For preventing IP, anti-CMV hyperimmune globulin was effective, while interferon and acyclovir were not.
authors: The Center for Adult Diseases, Osaka, Japan.
authors: H
authors: H
authors: Teshima
authors: T
authors: T
authors: Masaoka
authors: T
authors: T
authors: Inoue
authors: S
authors: S
authors: Kato
authors: K
authors: K
authors: Naito
authors: T
authors: T
authors: Mori
authors: A
authors: A
authors: Kanamaru
authors: Y
authors: Y
authors: Saito
authors: M
authors: M
authors: Ohira
authors: Y
authors: Y
authors: Moriyama
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage; D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; D007372:Interferons / Q000627:therapeutic use; D007564:Japan; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010356:Patient Isolation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D007106:Immune Sera; D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; C045781:cytomegalovirus-specific hyperimmune globulin; D007372:Interferons; D000212:Acyclovir