[Inhibition of synthesis of nucleic acids, proteins and respiration in isolated thymocytes by anthracyclines].
The effect of anthracycline antibiotics such as carminomycin, daunomycin (rubomycin) and adriamycin on respiration and synthesis of nucleic acids and protein was studied comparatively. The anthracyclines inhibited the processes. By their efficacy in that respect they could be arranged in the following order: carminomycin greater than rubomycin greater than adriamycin. Thus, 50 per cent inhibition of nucleic acid synthesis in the thymocytes required 0.027, 0.044 and 0,173 mM of carminomycin, rubomycin and adriamycin respectively. Protein synthesis and respiration in the thymocytes were less sensitive to the effect of the anthracyclines than synthesis of nucleic acids. The study results were compared with the literature data on the effect of the compounds on respiration and synthesis of nucleic acids and protein in tumour and bacterial cells.
Gorskaia
I A
IA
Komolova
G S
GS
Sheveleva
I D
ID
Kaverinskaia
T V
TV
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004247:DNA / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000187:drug effects; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D009698:Nucleoproteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D010101:Oxygen Consumption / Q000187:drug effects*; D012313:RNA / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000166:cytology*
D000903:Antibiotics, Antineoplastic; D009698:Nucleoproteins; D012313:RNA; D004247:DNA
Ingibirovanie antratsiklinami sinteza nukleinovykh kislot, belka i dykhaniia v izolirovannykh timotsitakh.