[The effect of 3'-azido-3'-deoxynucleosides on the reproduction of AIDS virus in cell culture].
Action of three nucleoside analogues with azido-group on AIDS virus (human immunodeficiency virus--HIV) reproduction was studied in two cell species. Among these compounds there were 3'-azido-3'-deoxythymidine (Az-T), 3'-azido-3'-deoxyarabinothymidine (Az-AT) and 3'-azido-2',3'-dideoxy-5-methylcytidine (Az-dCMe). All compounds prevent cells against HIV infection, but Az-T action was expressed more strongly. The reason for the lower activity of the Az-AT and Az-dCMe bases is probably stipulated by their poor conversion to the corresponding 5'-triphosphates. Az-T 5'-triphosphate blocks HIV reproduction due to the inhibition of the viral reverse transcriptase.
Galegov
G A
GA
Korneeva
M N
MN
Nosik
D N
DN
Kilesso
T Iu
TIu
Kraevskiĭ
A A
AA
D001386:Azides / Q000494:pharmacology*; D002478:Cells, Cultured; D015224:Dideoxynucleosides / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D012191:Retroviridae Proteins / Q000096:biosynthesis; D018894:Reverse Transcriptase Inhibitors; D012254:Ribavirin / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*; D016047:Zalcitabine / Q000031:analogs & derivatives*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001386:Azides; D015224:Dideoxynucleosides; D012191:Retroviridae Proteins; D018894:Reverse Transcriptase Inhibitors; D012254:Ribavirin; D015215:Zidovudine; D016047:Zalcitabine; C057658:3'-azido-2',3'-dideoxy-5-methylcytidine; C053667:3'-azido-3'-deoxyarabinothymidine
Deĭstvie 3'-azido-3'-dezoksinukleozidov na reproduktsiiu virusa SPID v kul'ture kletok.