Immune response to basal cell and squamous cell carcinomas.
Recent studies are starting to give us some insight into the immune response to basal and squamous cell carcinomas of the skin. There appear to be local as well as systemic mechanisms that effect local tumor growth. The local response may be analogous to delayed-type hypersensitivity with recognition of tumor antigens and a subsequent cell-mediated response. This response may be blunted by suppressor cell activity that has been well documented in the animal model related to UV-induced tumors and also suggested in certain patients with multiple BCCs. Continued research efforts in these areas will help us better understand the immune response to these two very common skin cancers.
Grimwood
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Wilford Hall Medical Center, Lackland Air Force Base, Texas.
D000818:Animals; D002280:Basal Cell Carcinoma / Q000276:immunology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular / Q000528:radiation effects; D007165:Immunosuppression Therapy; D016131:Lymphocyte Subsets / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology; D008819:Mice, Nude / Q000276:immunology; D009381:Neoplasms, Radiation-Induced / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects