Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.
Rats were chronically treated with chlordiazepoxide (CDP 10 mg/kg/day) or vehicle for 27 days. Twenty-four hours after their last dose, they received flumazenil (4 mg/kg) or vehicle and were tested in the social interaction test, in a low-light, familiar arena. CDP withdrawal significantly reduced the time spent in social interaction compared with controls, indicating an anxiogenic withdrawal response. This was completely reversed by flumazenil. A second group received CDP for 27 days and, in addition, received a single dose of flumazenil (4 mg/kg) 6 days before testing. Flumazenil prevented the development of the anxiogenic withdrawal response in these rats.
Baldwin
H A
HA
Psychopharmacology Research Unit, University of London, Guy's Hospital, UK.
File
S E
SE
D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology*; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D005442:Flumazenil; D002707:Chlordiazepoxide