title: Congenital leukemia: persistent spontaneous regression in a patient with an acquired abnormal karyotype.
abstract: Congenital leukemia is a rare disease accounting for about 1% of all leukemias in childhood. While cases associated with Down's syndrome not infrequently show a spontaneous regression, such an event is very rare in non-Down cases and exceptional in those (among the latter) which present clonal cytogenetic alterations in the neoplastic cells. We present the case of a patient with congenital leukemia and an abnormal karyotype (limited to the neoplastic clone), in which an apparently spontaneous and prolonged remission occurred after a relapse.
authors.affiliation: Center for Genetic Epidemiology and Oncogenetics, National Cancer Institute, Genova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Sansone
authors.forename: R
authors.initials: R
authors.lastname: Haupt
authors.forename: P
authors.initials: P
authors.lastname: Strigini
authors.forename: M L
authors.initials: ML
authors.lastname: Garrè
authors.forename: C
authors.initials: C
authors.lastname: Panarello
authors.forename: P
authors.initials: P
authors.lastname: Cornaglia-Ferraris
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D009365:Neoplasm Regression, Spontaneous; D012008:Recurrence