In vitro activity of S-ofloxacin.
S-Ofloxacin, the optically active form of ofloxacin, was twice as active as the S,R mixture of ofloxacin against members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and gram-positive species. Of the Enterobacteriaceae, 90% were inhibited by less than or equal to 1 microgram/ml and 90% of Staphylococcus aureus and Streptococcus pyogenes isolates were inhibited by 0.5 microgram/ml. Bacteroides fragilis was inhibited by 4 micrograms/ml. Organisms resistant to ofloxacin were resistant to S-ofloxacin. Like ofloxacin activity, the activity of S-ofloxacin was reduced by Mg2+ and by acid pH. Spontaneous mutational resistance to S-ofloxacin was similar to that to ofloxacin.
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Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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D001419:Bacteria / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013251:Steroid Isomerases
D003470:Culture Media; D002939:Ciprofloxacin; D015242:Ofloxacin; D013251:Steroid Isomerases; D008274:Magnesium; D002118:Calcium