Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin.
Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) augmented glucose-stimulated release of insulin in rats. Vagotomy increased this enhancement effect of i.c.v. calcitonin significantly, whereas peripheral atropine treatment did not change it. Adrenal catecholamines did not participate in the centrally mediated insulinotropic effect of calcitonin since acute adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. Destruction of the sympathetic ganglia by neonatal treatment with 6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which suggests that the sympathetic nervous system participates in the central action of calcitonin to enhance glucose-stimulated release of insulin.
Greeley
G H
GH
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
Cooper
C W
CW
Jeng
Y J
YJ
Eldridge
J C
JC
Thompson
J C
JC
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004357:Drug Synergism; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology; D015171:Ganglionectomy; D005947:Glucose / Q000494:pharmacology*; D006892:Hydroxydopamines; D007276:Injections, Intraventricular; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D016627:Oxidopamine; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014628:Vagotomy
D006892:Hydroxydopamines; D007328:Insulin; D001285:Atropine; D016627:Oxidopamine; D002116:Calcitonin; D005947:Glucose