title: [Light-chain deposition disease. Presentation of a case].
abstract: A case of 66-years-old woman with mild renal failure due to deposition of K light chains on glomerular nodules, is reported. Monoclonal K light chains were found by immunofixation in serum and concentrated urine. Bone marrow examination showed a moderate increase of plasma cells, all stained for K light chains. Amyloid was not identified. No chemotherapy was started. Despite this, in the 15-months follow-up, renal function was preserved; no signs of myeloma, nor of extrarenal involvement were found. Careful follow-up is emphasized. The reason why light chains form amyloidoses or nodular deposits, like diabetic glomerulosclerosis of Kimmelstiel-Wilson, is briefly discussed, together with the differential diagnosis from other nephropathies.
authors.forename: G
authors.initials: G
authors.lastname: Bertoli
authors.forename: P
authors.initials: P
authors.lastname: Ghiringhelli
authors.forename: A
authors.initials: A
authors.lastname: Bersiga
authors.forename: F
authors.initials: F
authors.lastname: Pecchini
authors.forename: E
authors.initials: E
authors.lastname: Betri
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology*; D007145:Immunoglobulin kappa-Chains; D007678:Kidney Glomerulus / Q000473:pathology; D009101:Multiple Myeloma / Q000175:diagnosis
chemical_list: D007145:Immunoglobulin kappa-Chains
vernacular_title: Malattia da depositi di catene leggere (lcdd). Presentazione di un caso.