Applications of a simultaneous atomic emission mass spectral gas chromatography detector in drug analysis.
For gas chromatographic eluents a microwave induced plasma (MIP) emission detector has two important features for a wide range of nonmetals. These features are (1) elemental selectivity and (2) the ability to determine elemental composition. These capabilities, used individually or in combination, can provide important information which is largely complementary to mass spectral data. Simultaneous determination of the MIP emission and mass spectral data for individual chromatographic peaks can be very useful in resolving a variety of problems encountered in pharmaceutical analysis. Several of these possible applications are illustrated with specific examples.
Hooker
D B
DB
Pharmaceutical Research and Development, Upjohn Company, Kalamazoo, MI 49001.
Dezwaan
J
J
D004340:Drug Contamination; D004602:Elements; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation*; D008872:Microwaves; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013053:Spectrophotometry; D013054:Spectrophotometry, Atomic / Q000295:instrumentation*
D004602:Elements; D004364:Pharmaceutical Preparations