[The effect of chemical sympathectomy on the cell kinetics of gastric mucosa in golden hamsters].
The effects of chemical sympathectomy on the differentiation of the generative cells, superficial epithelial cells and gastrin cells of the gastric mucosa of hamster were examined by 3H-thymidine autoradiography. The labeling indices of the generative cell zone in the gastric mucosa and antral gastrin cells showed a transient significant decrease after chemical sympathectomy, and then they were gradually restore with time. After 4 weeks onward, the labeling indices of the generative cells showed a slightly low value compared with those in controls. The renewal of superficial epithelial cells and gastrin cells was examined in the hamster sympathectomized for 4 weeks. The time required for the differentiation to PAS positive superficial epithelial cells or gastrin cells had a tendency to elogate after chemical sympathectomy. These results suggest that chemical sympathectomy played an inhibitive action on the proliferation and the differentiation of gastric mucosa.
Nakajima
C
C
Azuma
T
T
Magami
Y
Y
Sasaki
Z
Z
Kawai
K
K
Inokuchi
H
H
Kawai
T
T
Seki
T
T
Harada
Y
Y
Saito
T
T
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006224:Cricetinae; D005753:Gastric Mucosa / Q000166:cytology*; D006892:Hydroxydopamines; D008297:Male; D008647:Mesocricetus; D016627:Oxidopamine; D013563:Sympathectomy, Chemical
D006892:Hydroxydopamines; D016627:Oxidopamine