The effects of cyclophosphamide on the prolactin cells of the normal rat.
Cyclophosphamide administered at doses of 400 mg/m2/5 days with sacrifice two days later, and 200 mg/m2/5 days with a 21-day break and a further five days of treatment, with sacrifice two days later, provokes similar effects. Functional activity is less marked in untreated and control animals than in treated ones, as the hormone data shows. But the ultrastructure of PRL cells in treated animals indicates the existence of clear hormone synthesis activity, evident in the fusion and clustering of granules at differing stages of maturity, etc.
Poblador
M S
MS
Department of Morphological Sciences, Faculty of Medicine, University of Córdoba, Spain.
Rojas
C
C
Raya
A
A
Quiralte
J
J
Casares
J A
JA
Lancho-Alonso
J L
JL
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
D003520:Cyclophosphamide; D011388:Prolactin