[Monoclonal gammopathies of undetermined significance called "MGUS"].
While the discovery of a monoclonal gammopathy in the blood of a patient sometimes leads to the diagnosis of multiple myeloma, immunocytoma or other B-cell lymphoproliferative syndromes, "secondary" monoclonal dysproteinemia is seldom considered. In most cases "monoclonal gammopathy of undetermined significance" (MGUS) is diagnosed. After ten years about 25% of these cases evolve to true multiple myeloma or Waldenström's disease. Other MGUS usually remain asymptomatic, though sometimes a complication such as amyloidosis or cryoglobulinemia may occur as a result of the "perverse" effect of the monoclonal protein. Some cases are described.
Clément
F
F
Division d'hématologie, Centre hospitalier universitaire vaudois, Lausanne.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis / Q000209:etiology*; D009101:Multiple Myeloma / Q000150:complications; D008258:Waldenstrom Macroglobulinemia / Q000150:complications
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains
Les gammopathies monoclonales de signification indéterminée dites "MGUS".