Changes in the absorption of bile acids after total colectomy in patients with an ileostomy or pouch-anal anastomosis.
Bile acid absorption was investigated using 75Se Taurohomocholate (SeHCAT) in controls and patients who had undergone total colectomy with either conventional ileostomy or pouch-anal anastomosis for ulcerative colitis or adenomatous polyposis. Whole-body retention of SeHCAT after 168 hours was greater in the controls than the patients who had undergone colectomy (P less than .05). Retention of SeHCAT did not differ significantly between patients with an ileostomy and patients with pouch-anal anastomosis, but patients with an ileostomy and ileal resection of more than 20 cm retained less SeHCAT than patients with a pouch-anal anastomosis (P less than .01). Analysis of fecal bile acids from ileostomies and pouches showed that bacterial metabolism of primary conjugated bile acids was greater in patients with a pouch. It was concluded that bile acid absorption was not significantly impaired by construction of a pouch compared with conventional ileostomy, but bacterial metabolism of bile acids was greater in the pouches.
Nasmyth
D G
DG
University Department of Surgery, General Infirmary, Leeds, United Kingdom.
Johnston
D
D
Williams
N S
NS
King
R F
RF
Burkinshaw
L
L
Brooks
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D000714:Anastomosis, Surgical; D001647:Bile Acids and Salts / Q000378:metabolism*; D003082:Colectomy; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000378:metabolism / Q000601:surgery; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D014915:Whole-Body Counting
D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid