title: Complex partial status epilepticus associated with cyclosporin A therapy.
abstract: Significant neurotoxicity including seizures, encephalopathy and coma may complicate the use of cyclosporin A (CyA). Two patients are described, receiving CyA, who presented with abnormal behaviour, stupor, focal motor activity and were shown to be in complex partial status epilepticus (CPSE). Abnormalities of behaviour and/or stupor in patients receiving CyA may be a manifestation of CPSE. Patients receiving CyA who develop an encephalopathy should have electroencephalography performed at the time of the abnormal behaviour.
authors.affiliation: Department of Paediatrics, University of British Columbia, Vancouver, Canada.
authors.forename: R E
authors.initials: RE
authors.lastname: Appleton
authors.forename: K
authors.initials: K
authors.lastname: Farrell
authors.forename: P
authors.initials: P
authors.lastname: Teal
authors.forename: S A
authors.initials: SA
authors.lastname: Hashimoto
authors.forename: P K
authors.initials: PK
authors.lastname: Wong
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male
chemical_list: D003524:Cyclosporins