Altered biodistribution of Ga-67 by intramuscular gold salts.
The authors observed a deviation from the normal scintigraphic pattern of Ga-67 citrate biodistribution. An 8-year-old black girl with juvenile rheumatoid arthritis, who had been treated with intramuscular injections of gold salts, had a Ga-67 study as part of her workup. The study demonstrated no hepatic uptake, but showed elevated skeletal and renal activity. This characteristic biodistribution of Ga-67 may be due to inhibition of lysosomal enzymes by gold and/or to accumulation of gold in lysosomes. To study these possibilities, the authors reviewed the mechanisms of Ga-67 localization and gold metabolism. Alteration of the Ga-67 citrate scintigraphic pattern due to earlier treatment with gold salts has not been reported previously.
Moult
R G
RG
Chicago Osteopathic Medical Center, Illinois.
Bekerman
C
C
D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002648:Child; D002951:Citrates / Q000493:pharmacokinetics*; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D009288:Naproxen / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D002951:Citrates; D005710:Gallium Radioisotopes; D006052:Gold Sodium Thiomalate; D019343:Citric Acid; D009288:Naproxen; D011241:Prednisone