title: Squamous cell carcinoma in porokeratosis in two patients.
abstract: Malignancy arising in porokeratoses is a well recognised but infrequently reported complication. Histological studies suggest that malignancy arises from the abnormal clone of keratinocytes which produce the cornoid lamella. We report two cases of squamous cell carcinoma arising in porokeratoses and postulate genetic, environmental and host factors as important in the evolution of their malignancy.
authors.affiliation: Skin and Cancer Foundation, Darlinghurst, NSW.
authors.forename: A
authors.initials: A
authors.lastname: O'Neill
authors.forename: C A
authors.initials: CA
authors.lastname: Commens
authors.forename: S
authors.initials: S
authors.lastname: Kossard
authors.forename: H
authors.initials: H
authors.lastname: Coats
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology