The effects of CDP-choline on newborn rat pups with experimental alcohol fetopathy. A Golgi study.
Generally accepted features of alcoholic fetopathy are delayed maturation and retarded dendritic development of neocortex, hippocampus and cerebellum. The present study investigates the effects of a membrane stabilizing agent (CDP-choline) on Purkinje cells of chronically alcohol intoxicated newborn rat pups, employing a Golgi impregnation technique. Both quantitative and qualitative data indicate that CDP-choline modifies the alcohol induced lesion.
Patt
S
S
Institute of Neuropathology, Free University of Berlin, FRG.
Cervós-Navarro
J
J
Stoltenburg-Didinger
G
G
Schreiner
C
C
D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology*; D001921:Brain / Q000473:pathology; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D003712:Dendrites / Q000648:ultrastructure; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000188:drug therapy / Q000473:pathology*; D011247:Pregnancy; D011689:Purkinje Cells / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling; D016610:Tissue Embedding
D003566:Cytidine Diphosphate Choline