Effects of 2-nitratopropyl 3-nitratopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate on cerebral circulation and metabolism in cats.
Effects of CD-349 (2-nitratopropyl 3-nitratopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) on cerebral circulation and metabolism were examined measuring cerebral oxygen and carbon dioxide tension (BrPO2, BrPCO2), pH (BrpH) and mean arterial blood pressure (MABP) in cats. CD-349 of 10 micrograms/kg infused into the carotid artery produced a remarkable and long-lasting decrease in systemic blood pressure, whereas BrPO2, BrPCO2 and BrpH did not change significantly. The previous studies have already demonstrated that CD-349 increases cerebral blood flow (CBF). In addition to the improvement of the cerebral circulation, the present study suggests that C-349 may augment cerebral metabolism.
Izumi
Y
Y
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
Isozumi
K
K
Fukuuchi
Y
Y
Gotoh
F
F
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004095:Dihydropyridines / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D013997:Time Factors
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D002245:Carbon Dioxide; C054179:CD 349