title: [Therapeutic difficulties in discontinuous absence-petit mal status].
abstract: After a change in her antiepileptic medication, a 29 year old woman, who had petit mal absences since childhood, developed an intoxication by phenobarbital and a intermittent absence status. The intravenous administration of clonazepam paradoxically produced a transitory increase of the spike-wave-activity. Only 8 days later, when the serum level of phenobarbital had dropped and the concentration of valproic acid and ethosuximide were near the "therapeutic range", did the absences remit.
authors.affiliation: Abteilung für Epileptologie und Elektroenzephalographie, Neurologischen Universitätsklinik, Bern.
authors.forename: F
authors.initials: F
authors.lastname: Donati
authors.forename: M
authors.initials: M
authors.lastname: Wiederkehr
authors.forename: K
authors.initials: K
authors.lastname: Karbowski
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans
chemical_list: D000927:Anticonvulsants
vernacular_title: Therapeutische Schwierigkeiten bei einem diskontinuierlichen Absencen-Petit mal-Status.