title: Isodicentric X chromosome in myeloproliferative disorders.
abstract: Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
authors.affiliation: Second Medical Clinic, University of Modena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Temperani
authors.forename: P
authors.initials: P
authors.lastname: Zucchini
authors.forename: G
authors.initials: G
authors.lastname: Emilia
authors.forename: S
authors.initials: S
authors.lastname: Sacchi
authors.forename: L
authors.initials: L
authors.lastname: Selleri
authors.forename: U
authors.initials: U
authors.lastname: Torelli
mesh_terms: D000368:Aged; D002871:Chromosome Banding; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D055728:Primary Myelofibrosis / Q000235:genetics / Q000473:pathology; D012729:Sex Chromosome Aberrations / Q000235:genetics / Q000473:pathology; D014960:X Chromosome / Q000648:ultrastructure*
chemical_list: D004273:DNA, Neoplasm; D004247:DNA