[Ambulatory registration of arterial pressure during treatment with perindopril. Effects on systolic pressure and hemodynamic implications].
The effects of perindopril on the 24-hour arterial pressure levels were evaluated by ambulatory recording in 21 patients (mean age 48 +/- 2 years) with mild to moderate hypertension. At the end of a 3 months treatment with perindopril (4 to 8 mg per day in one dose), comparison by variance analysis of the mean values of arterial pressure over 24 hours before and after treatment showed a significant decrease of SAP (from 144 +/- 3 to 133 +/- 3 mmHg, p less than 0.01) and DAP (from 95 +/- 2 to 87 +/- 2 mmHg, p less than 0.01). The fall in arterial pressures was more pronounced during day-time (7 a.m. to 10 p.m.) than at night. Particular attention was paid to the reduction of systolic pressure owing to its relation with arterial compliance. There was a significant correlation between ambulatory recordings of SAP and DAP before and after treatment (r = 0.82 and 0.76 respectively, p less than 0.001). Calculation and comparison of the corresponding regression slope showed that for any given level of DAP, SAP was lower after than before treatment. This effect is related to the increase of arterial compliance observed after treatment with perindopril, as already reported by other authors.
Santoni
J P
JP
Centre de diagnostic de l'hôpital Broussais, Paris, France.
Asmar
R G
RG
Bizot-Espiard
J G
JG
Safar
M
M
D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination / Q000379:methods; D003971:Diastole; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D020913:Perindopril; D013599:Systole
D000959:Antihypertensive Agents; D007211:Indoles; D020913:Perindopril
Enregistrement ambulatoire de la pression artérielle lors d'un traitement par le perindopril. Effets sur la pression systolique et implications hémodynamiques.