title: Localized grade I non-Hodgkin's lymphoma: results of treatment with radiotherapy alone in 88 patients.
abstract: Eighty-eight patients entered into the British National Lymphoma Investigation with clinical stage I and II, grade I non-Hodgkin's lymphoma were treated initially with involved field radiotherapy alone. Eighty-one per cent presented with nodal disease. The duration of follow-up was 25-116 months, with a median of 54 months. Fifteen patients died of disease and the 5-year survival of the whole group was 83%. The complete response rate was dependent on the radiotherapy dose and was greater than 90% for doses of 3500 cGy and over. Most failures occurred at distant rather than adjacent sites, suggesting that extended field radiotherapy would not have affected the outcome. Second-line treatment induced complete remission in 66% of patients who relapsed. The prognosis was significantly worse in patients with intra-abdominal disease.
authors.affiliation: Department of Oncology, University College and Middlesex School of Medicine, London, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Spry
authors.forename: D S
authors.initials: DS
authors.lastname: Lamb
authors.forename: G
authors.initials: G
authors.lastname: Vaughan Hudson
authors.forename: M J
authors.initials: MJ
authors.lastname: Easterling
authors.forename: K A
authors.initials: KA
authors.lastname: MacLennan
authors.forename: A M
authors.initials: AM
authors.lastname: Jelliffe
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D015996:Survival Rate