The in vitro activity of tigemonam: a comparison with other antimicrobial agents.
The activity of tigemonam was compared with that of aztreonam, cefuroxime, cephalexin, amoxicillin/clavulanate potassium, gentamicin, and ofloxacin, using an agar dilution method. Tigemonam was active against strains containing known beta-lactamases of Tem and Oxa types, but strains containing broad-spectrum (group IV) enzymes were less susceptible. The MIC90 of tigemonam against the common Enterobacteriaceae was less than or equal to 0.25 mg/L. The MIC90S against Haemophilus influenzae and Neisseria gonorrhoeae were 0.5 and 0.06 mg/L, respectively. Pseudomonas, staphylococci, and Bacteroides sp. were less susceptible (MIC90 greater than 128 mg/L). Protein binding in human serum was found to be 62.5%; the presence of serum had only a modest effect on the activity of tigemonam.
Andrews
J M
JM
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
Wise
R
R
D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D008997:Monobactams; C052020:tigemonam