title: [Blood lipids and the clinical state of hormone-treated women during menopause].
abstract: The aim of the work was to investigate the influence on lipids and lipoproteins in blood serum exerted by smallest, preventing hot flushes, doses of mestranol and diethylstilbestrol administered with chlormadinon by sequential method as well as estriol by cyclic method. In the studied women, prior to treatment, after 1, 3 and 6 months of therapy, the made evaluation also covered the intensity of climacteric symptoms according to Kupermann scale, and the concentration of FSH, LH, estadiol as well as testosterone in blood serum. Moreover the arterial blood pressure and the body mass were measured. The treatment involved 82 women, and was carried out by resorting to: mestranol in a dose from 0.025 mg to 0.1 mg in 29 females, diethylstilbestrol in a dose ranging from 0.125 mg to 0.5 mg in 30 females, and estriol in a dose from 1 mg to 3 mg in 25 women. Estrogenic drugs were given from the 5th to 25th day of the cycle and chlormadinon (2 mg) from the 16th to 25th day of the cycle. Lipids and lipoproteins were determined in 65 females. The respective climacteric symptoms decreased equally significantly and at a similar pace in consequence of the treatment provided by three methods. The values of Kupermann's index decreased from the compartment 15-50 to 0-15 points. Concentration of FSH and testosterone would not change in the course of the treatment. On the other hand, diminution was recorded in LH concentration after 3 month-long administration of mestranol and after 6 months-long use of estriol. There is also an increase after the first month, and subsequently a significant decrease of estradiol concentration in women treated with mestranol. In the same group of women, lowering of arterial, systolic and diastolic blood pressure was recorded after 6 months of therapy. Systolic pressure decreased also in 6 women receiving estriol, under the influence of diethylstilbestrol and chlormadinon arterial blood pressure did not change. No change in the body mass of the treated women took place. Evaluating the changes in concentration of lipids and lipoproteins in the blood serum, during the treatment, it was stated that as compared with initial values there was a significant rise in the concentration of HDL cholesterol in the group of females treated with mestranol and diethylstilbestrol with chlormadinon; as well as of HDL phospholipids in women being given estriol, and also in women taking diethylostilbestrol with chlormadinon. An increase in concentration of total phospholipids was also revealed in the latter two groups of women.(ABSTRACT TRUNCATED AT 400 WORDS)
authors.forename: M
authors.initials: M
authors.lastname: Dominiczak-Gawrońska
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002715:Chlormadinone Acetate / Q000008:administration & dosage*; D002979:Climacteric / Q000187:drug effects / Q000502:physiology*; D004359:Drug Therapy, Combination; D045166:Estradiol Congeners / Q000008:administration & dosage*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008593:Menopause / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
chemical_list: D045166:Estradiol Congeners; D006065:Gonadotropins, Pituitary; D008055:Lipids; D002715:Chlormadinone Acetate; D013739:Testosterone
vernacular_title: Lipidy krwi oraz stan kliniczny kobiet leczonych hormonalnie w okresie przekwitania.