Effects of extracellular calcium and sodium on cadmium uptake in guinea-pig and rabbit aorta.
1. Effects of Na+ and Ca2+ on Cd2+ uptake in the guinea-pig and rabbit aorta were investigated. 2. The Cd2+ fraction can be divided with EDTA and Zn2+. The EDTA fraction may be intracellular fraction and the Zn2+ fraction may be loosely bound to surface membrane. 3. In Na+ deficient solution the Zn2+ fraction was markedly increased and the EDTA fraction also increased while the external Ca2+ concentrations scarcely affect the Cd2+ contents in both fractions. 4. Cd2+ did not affect the cellular Na+ and K+ contents. 5. These results suggest that Na+ strongly relates with these fractions but Na+ pump does not contribute to these phenomena.
Ueda
F
F
Department of Veterinary Public Health, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
Nagata
M
M
Nagata
T
T
Shimazaki
Y
Y
D000818:Animals; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
D002104:Cadmium; D004492:Edetic Acid; D012964:Sodium; D015032:Zinc; D011188:Potassium; D002118:Calcium