Regulation of B lymphocytes by natural killer cells. Role of IFN-gamma.
Using a co-culture system of fractionated B cells and highly purified NK cells, we have demonstrated direct interactions between B lymphocytes and NK cells. B cells are able to stimulate the production of IFN-gamma by NK cells. This stimulatory ability is restricted to a subpopulation of large, presumably in vivo activated B lymphocytes. The secreted IFN-gamma in turn inhibits polyclonally induced B cell proliferation. Small resting B cells neither stimulate IFN-gamma production nor are they measurably affected by NK cells.
Michael
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Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Hackett
J J
JJ
Bennett
M
M
Kumar
V
V
Yuan
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D
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D006131:Growth Inhibitors / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology; D007136:Immunoglobulins / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
D006131:Growth Inhibitors; D007106:Immune Sera; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D007371:Interferon-gamma