Treatment of fever and neutropenia with antibiotics versus antibiotics plus intravenous gammaglobulin in childhood leukemia.
Thirty-three children with leukemia who had neutropenia and fever were randomized to receive cefataxim and amikacin, versus the same antibiotics plus intravenous gammaglobulin (i.v. IgG). Duration of neutropenia, hospitalization and the interruption of chemotherapy were not different in the two groups; however, duration of fever was significantly shorter in the i.v. IgG group.
Sumer
T
T
Department of Pediatrics, Robert Wood Johnson University Hospital, New Brunswick, NJ 08903.
Abumelha
A
A
al-Mulhim
I
I
al-Fadil
M
M
D000380:Agranulocytosis / Q000150:complications*; D000583:Amikacin / Q000008:administration & dosage* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D002439:Cefotaxime / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005334:Fever / Q000139:chemically induced / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous; D017053:Infection Control; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy
D000970:Antineoplastic Agents; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D000583:Amikacin; D002439:Cefotaxime