title: [Glucagon is processed to the (19-29) fragment at the level of the hepatocyte membrane].
abstract: Upon incubation with hepatic plasma membranes, glucagon is processed into its (19-29) C-terminal fragment. This suggests that, in physiological conditions, glucagon is processed in a target tissue at the level of its Arg17-Arg18 basic doublet, leading to the production of a fragment which is known to display an original biological specificity, namely the modulation of the calcium pump present in hepatocyte plasma membrane.
authors.affiliation: Centre C.N.R.S.-I.N.S.E.R.M. de Pharmacologie-Endocrinologie, Montpellier.
authors.forename: P
authors.initials: P
authors.lastname: Blache
authors.forename: A
authors.initials: A
authors.lastname: Kervran
authors.forename: M
authors.initials: M
authors.lastname: Dufour
authors.forename: J
authors.initials: J
authors.lastname: Martinez
authors.forename: D
authors.initials: D
authors.lastname: Le-Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Lotersztajn
authors.forename: C
authors.initials: C
authors.lastname: Pavoine
authors.forename: F
authors.initials: F
authors.lastname: Pecker
authors.forename: D
authors.initials: D
authors.lastname: Bataille
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005934:Glucagon / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D010443:Peptide Chain Termination, Translational; D010446:Peptide Fragments / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats
chemical_list: D010446:Peptide Fragments; D005934:Glucagon
vernacular_title: Le glucagon est maturé en fragment (19-29) au niveau de la membrane hépatocytaire.