[Effect of nisoldipine on cultured myocardial cells of neonatal rats].
Nisoldipine 1.5 nmol/L, 0.75, and 1.5 mumol/L depressed the beat rates of myocardial cells. The effects were negatively correlated with dosages. Nisoldipine depressed the beat rates increased by calcium chloride 0.15 mmol/L or isoprenaline 1.5 mumol/L and atropine 20 nmol/L. Conversely, the above drugs reversed the beat rates depressed by nisoldipine. Therefore, the acting nisoldipine may be antagonistic to calcium chloride, isoprenaline and atropine. In addition, nisoldipine 10 nmol/L may significantly aggravated the damage to myocardial cells induced by mitomycin C 5 micrograms/ml in which elevated lactate dehydrogenase appeared.
Yang
J C
JC
Yu
C L
CL
Zhang
J X
JX
Gu
W X
WX
Ding
M X
MX
Yao
Y F
YF
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002121:Calcium Channel Blockers; D002122:Calcium Chloride / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology; D015737:Nisoldipine / Q000494:pharmacology*; D051381:Rats
D002121:Calcium Channel Blockers; D008937:Mitomycins; D015737:Nisoldipine; D016685:Mitomycin; D001285:Atropine; D007770:L-Lactate Dehydrogenase; D007545:Isoproterenol; D002122:Calcium Chloride