Hepatic actions of levonorgestrel: correlations between biochemical and morphological findings.
The influence of the synthetic sexual steroid levonorgestrel (LN) on rat liver in various doses and at different structural levels was investigated. A slight reactive hepatosis was found by histological examination after administration of LN in a dose of 10 mg per kg body wt. The same dose caused exclusively distinct lesions of the mitochondria, however, only in centrilobular parenchymal cells, whereas in the periportal hepatocytes only the lipid droplet content appears somewhat elevated. LN decreased the total glutathione content of the liver. The mitochondrial glutathione was decreased more intensively. One mg/kg body wt. of LN decreased the cytochrome P-450 content, but 10 mg/kg body wt. increased ethyl-morphine N-demethylation and 7-ethoxycoumarin O-deethylation activities. Distinct correlations could be shown between the biochemical changes and the ultrastructural findings.
Kretzschmar
M
M
Institute of Pharmacology and Toxicology, Friedrich-Schiller-University, Jena, G.D.R.
Giese
R
R
Franke
H
H
Machnik
G
G
Klinger
W
W
D000818:Animals; D003277:Contraceptives, Oral, Combined; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D016912:Levonorgestrel; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects; D009644:Norgestrel / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D016912:Levonorgestrel; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione