A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.
Peripheral blood CD8+ T lymphocytes from human immunodeficiency virus (HIV)-infected individuals suppress replication of HIV in peripheral blood mononuclear cells (PBMC). This anti-viral activity appears to be mediated in part by a diffusible factor. Production of this lymphokine varies among infected individuals and may reflect the intrinsic ability of an individual's CD8+ cells to control HIV infection. In some cases in which factor activity is not apparent, contact of the CD8+ cells with infected CD4+ cells can produce for suppression of virus replication. These observations could lead to approaches for enhancing anti-viral responses in HIV-infected individuals.
Walker
C M
CM
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
Levy
J A
JA
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D016827:CD8 Antigens; D015194:Diffusion Chambers, Culture; D006678:HIV / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D014779:Virus Replication
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D008222:Lymphokines