Effect of thyrotropin-releasing hormone (TRH) on the chemiluminescence (CL) activity of human mononuclear cells.
The effect of the tripeptide TRH on the chemiluminescence activity of human monocytes was tested. TRH significantly (p less than 0.002) inhibited monocytes activity at pharmacological concentrations of 2 x 10(-4) M/L. The effect was not mediated via Ia or C3a-receptors as was proven by the preincubation of monocytes with the monoclonal antibodies OKIa1 and anti-C3a. Heat inactivation abolished the effect of TRH. This study has demonstrated for the first time, that pharmacological doses of TRH which had already been tentatively employed as a therapeutic agent in men can modulate immunocompetent cells.
Lersch
C
C
Department of Internal Medicine II, Technical University of Munich, West Germany.
Hammer
C
C
Krombach
F
F
Dancygier
H
H
D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone