Refractory anemia terminating in acute megakaryoblastic leukemia (M7).
A 72-year-old man with refractory anemia (RA) developed overt megakaryoblastic leukemia after the course of RA with excess of blasts. The blasts were positive for platelet peroxidase activity and had platelet glycoproteins (GPs) such as GPIIb/IIIa and GPIIIa. The bone marrow biopsy at terminal stage disclosed marked fibrosis. The nature of the megakaryoblasts was investigated. The blasts did not differentiate morphologically into mature megakaryocytes with TPA addition. In vitro colony assay showed the failure of colony-forming unit, megakaryocyte growth in peripheral blood. The pathogenesis of myelofibrosis in our patient is discussed.
Adachi
M
M
Department of Laboratory Medicine, Kobe University School of Medicine, Japan.
Ryo
R
R
Yoshida
A
A
Yamaguchi
N
N
Izumi
Y
Y
D000368:Aged; D000753:Anemia, Refractory / Q000097:blood / Q000473:pathology*; D000954:Antigens, Surface / Q000032:analysis; D001752:Blast Crisis / Q000648:ultrastructure; D001792:Blood Platelets / Q000201:enzymology; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000097:blood / Q000473:pathology*; D008297:Male; D010544:Peroxidases / Q000097:blood; D014407:Tumor Cells, Cultured / Q000648:ultrastructure; D014410:Tumor Stem Cell Assay
D000954:Antigens, Surface; D010544:Peroxidases