Bacterial chemistry-III: preliminary studies on trypanosomal activities of Chromobacterium violaceum products.
It has been found that the pigment-I from Chromobacterium violaceum, 3-[1,2-dihydro5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-yli diene] 1,3-dihydro-2H-indol-2-one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 microM after 48 h of interaction with a total growth inhibition in the same period. Pigment-I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound.
Durán
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N
Biological Chemistry Laboratory, Universidade Estadual de Campinas, SP, Brazil.
Campos
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V
Riveros
R
R
Joyas
A
A
Pereira
M F
MF
Haun
M
M
D000818:Animals; D014355:Chagas Disease / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D002861:Chromobacterium / Q000378:metabolism*; D006224:Cricetinae; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D014344:Trypanocidal Agents