Selective segmental hepatic necrosis produced by the Shwartzman mechanism in rabbits.
In this study, a new experimental model for hepatic necrosis is presented using rabbits, and E. coli endotoxin as the Shwartzman reagent. A segment of the liver was chosen as a target site for the univisceral Shwartzman reaction. Endotoxin-Lipiodol emulsion was used as a preparative injection via the portal venous branch into the target segment by direct puncture. Provocation was made by an intravenous injection of endotoxin 24 h later. A marked and sharply demarcated necrotic area was produced selectively in the target segment; specific changes were not seen in other lobes of the liver or other parts of the body. This model, strongly enhanced by using Lipiodol, seems to be a subtype of the univisceral Shwartzman reaction of the liver.
Ohno
Y
Y
Department of Pathology, Faculty of Medicine, University of Tokyo, Japan.
Shiga
J
J
Mori
W
W
D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins / Q000494:pharmacology / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D008099:Liver / Q000473:pathology*; D009336:Necrosis; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000473:pathology*
D004731:Endotoxins