title: The effect of prolactin on calcium homeostasis in coho salmon (Oncorhynchus kisutch).
abstract: The response of plasma prolactin (PRL) to manipulations of plasma calcium were investigated in coho salmon. Injection of 3.16 mumol EGTA/10 g body weight (to reduce the plasma calcium activity) resulted in significantly higher plasma PRL levels. Lower doses of EGTA (1.06 and 2.13 mumol/10 g body wt) had no effect on plasma PRL concentrations. Injection of 8.75 mumol CaCl2/10 g body wt (but not 4.35 mumol CaCl2/10 g body wt) resulted in significantly lower plasma PRL levels. Plasma total calcium and sodium concentrations were significantly elevated following three daily injections of 0.5 micrograms/g pure chum salmon PRL. This is the first report of a role for salmon PRL in calcium homeostasis of Oncorhynchus.
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: R C
authors.initials: RC
authors.lastname: Fargher
authors.forename: B A
authors.initials: BA
authors.lastname: McKeown
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood* / Q000378:metabolism; D002122:Calcium Chloride / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects*; D011388:Prolactin / Q000097:blood / Q000494:pharmacology*; D012474:Salmon / Q000378:metabolism*; D012964:Sodium / Q000097:blood
chemical_list: D004533:Egtazic Acid; D011388:Prolactin; D012964:Sodium; D002122:Calcium Chloride; D002118:Calcium