2-Chlorobenzylidene malonitrile (CS) causes spindle disturbances in V79 Chinese hamster cells.
Exposure of V79 Chinese hamster cells to 2-chlorobenzylidene malonitrile (CS), a chemical used as a sensory irritant for riot control, caused a concentration-dependent increase in the incidence of spindle disturbances. A C-mitotic effect with the appearance of C-metaphases, a metaphase block and the concomitant disappearance of ana-telophase figures were observed after a 3-h treatment. The results indicate that CS might induce aneuploidy in mammalian cells by interacting with the mitotic apparatus.
Schmid
E
E
Institut für Strahlenbiologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg/Munich, F.R.G.
Bauchinger
M
M
Ziegler-Skylakakis
K
K
Andrae
U
U
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008938:Mitosis / Q000187:drug effects*; D009570:Nitriles / Q000633:toxicity*; D008941:Spindle Apparatus / Q000187:drug effects*; D009763:o-Chlorobenzylidenemalonitrile / Q000633:toxicity*
D009570:Nitriles; D009763:o-Chlorobenzylidenemalonitrile