title: Synthesis of listeriolysin in Listeria monocytogenes under heat shock conditions.
abstract: Listeriolysin, produced by all virulent Listeria monocytogenes isolates, is an essential virulence factor which appears to be necessary for the intracellular survival of these bacteria. It has been postulated that the intracellular environment imposes stress conditions similar to heat shock on invading bacteria. We show here that listeriolysin was still very efficiently synthesized in one Listeria monocytogenes strain even intracellularly and induced under heat shock conditions in another L. monocytogenes strain. Listeriolysin appears to be the only major extracellular protein synthesized under heat shock conditions; all other heat shock proteins remain cell associated.
authors.affiliation: Institut für Genetik und Mikrobiologie, Universität Würzburg, Federal Republic of Germany.
authors.forename: Z
authors.initials: Z
authors.lastname: Sokolovic
authors.forename: W
authors.initials: W
authors.lastname: Goebel
mesh_terms: D001427:Bacterial Toxins; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D006460:Hemolysin Proteins; D015151:Immunoblotting; D008089:Listeria monocytogenes / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; C038705:hlyA protein, Listeria monocytogenes