Mouse strain variations in the magnitude of induction of liver DT-diaphorase and hereditary transmission of the trait.
1. Strain variations among mice in terms of cytosolic DT-diaphorase activity were studied in liver, kidney, stomach and heart tissues with or without the administration of 3-tert-butyl-4-hydroxyanisole (BHA). 2. BHA induced DT-diaphorase activity in all strains examined, and the magnitude of induction varied depending on the strain and tissue. Among the 10 inbred strains tested, BALB/c and C57BL mice showed relatively large magnitudes of induction for liver DT-diaphorase, whereas C3H and CBA mice showed relatively small magnitudes. 3. Results of examinations of BALB/c-C3H-F1, -F2 and C57BL-CBA-F1 mice revealed that smaller magnitudes of induction of liver DT-diaphorase were inherited essentially as a dominant trait. The hereditary trait could be adequately explained by postulating two gene loci that regulate the magnitude of induction. 4. The possible significance of DT-diaphorase activity in chemical carcinogenesis was discussed.
Horie
S
S
Department of Biochemistry, School of Medicine, Kitasato University, Kanagawa, Japan.
Watanabe
T
T
Sone
Y
Y
Takayama
K
K
Ikeda
H
H
Takizawa
N
N
D000818:Animals; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D014644:Genetic Variation; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D009206:Myocardium / Q000201:enzymology; D016660:NAD(P)H Dehydrogenase (Quinone); D009603:Nitroso Compounds / Q000378:metabolism; D011808:Quinone Reductases / Q000096:biosynthesis* / Q000235:genetics; D013270:Stomach / Q000201:enzymology; D014812:Vitamin K / Q000378:metabolism
D009603:Nitroso Compounds; D014812:Vitamin K; D002083:Butylated Hydroxyanisole; C028992:4-nitrosophenol; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases