Biosynthesis of phenolic glycolipids in M. microti.
Mycobacterium microti readily incorporates radioactive propionate into phenolic glycolipids and phthiocerol dimycocerosates. This process is inhibited by 2- and 3-fluoropropionic acids at concentrations which do not affect overall growth. Incorporation is also inhibited by N-(phosphonomethyl) glycine, an inhibitor of the synthesis of aromatic units, but only at high concentrations which also inhibit bacterial growth.
Thurman
P
P
National Institute for Medical Research, Mill Hill, London, England.
Draper
P
P
D000942:Antigens, Bacterial; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006017:Glycolipids / Q000096:biosynthesis*; D008055:Lipids / Q000096:biosynthesis; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism; D000097797:Glyphosate
D000942:Antigens, Bacterial; D005998:Glycine; D006017:Glycolipids; D008055:Lipids; D010636:Phenols; D000097797:Glyphosate; C045169:phenolic glycolipid I, Mycobacterium leprae; C054991:mycoside B; C008901:phthiocerol dimycocerosate