title: Amyloid beta protein precursor is a mitogen.
abstract: The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
authors.affiliation: Salk Institute for Biological Studies, San Diego, California 92138.
authors.forename: D
authors.initials: D
authors.lastname: Schubert
authors.forename: G
authors.initials: G
authors.lastname: Cole
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Oltersdorf
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000682:Amyloid / Q000235:genetics / Q000502:physiology*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D003470:Culture Media; D005347:Fibroblasts / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007668:Kidney; D051379:Mice; D011480:Protease Inhibitors / Q000502:physiology; D011498:Protein Precursors / Q000235:genetics / Q000502:physiology*; D014162:Transfection
chemical_list: D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D003470:Culture Media; D006133:Growth Substances; D011480:Protease Inhibitors; D011498:Protein Precursors