An arginine specific carboxypeptidase generated in blood during coagulation or inflammation which is unrelated to carboxypeptidase N or its subunits.
An unstable carboxypeptidase N or B like enzyme is generated as a result of coagulation. This enzyme is derived from some plasma component (s) and not from blood cells or platelets. Furthermore, the activity generated is specific for arginine substrates insofar as small synthetic substrates are concerned. The enzyme is unrelated to CPN or any of its subunits or subunit fragments. This transient carboxypeptidase may be involved in the processing and/or scheduling of different functions of bioactive peptides generated during inflammation.
Campbell
W
W
Department of Molecular Biology, Nagoya City University School of Medicine, Japan.
Okada
H
H
D001120:Arginine; D001777:Blood Coagulation; D002268:Carboxypeptidases / Q000097:blood*; D002845:Chromatography; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D008239:Lysine; D001121:Lysine Carboxypeptidase / Q000097:blood; D013379:Substrate Specificity
D001120:Arginine; D002268:Carboxypeptidases; D001121:Lysine Carboxypeptidase; D008239:Lysine