[Combined effect of cis-DDP (II), OK-432 and systemic hyperthermia in ascites tumor in mice].
Combined effect of cis-DDP (II) (CDDP), a streptococcal preparation (OK-432) and systemic hyperthermia on ascites tumor in mice was studied. Tumor cells were of a syngeneic cloned cell line FMA3 which was derived from Furth's mastocytoma. When number of cells transplanted into the abdominal cavity was at 10(5), a single i.p. injection of CDDP at a dose of 4 mg/kg was effective to increase the mean survival time by a factor of 1.6. OK-432 given i.p. at a dose of 5 KE/kg on every two days between day 2 and day 10 after transplantation decreased the mean survival times. Even when it was used in combination with CDDP, enhancement of the effect of CDDP was not statistically significant. However, by the factorial analysis of the all data obtained in the experiments carried out with tumor cells of the number of 10(2), 10(3), 10(4) and 10(5), enhancement of the effect of CDDP by OK-432 was significant. Systemic hyperthermia of the core-body temperature of 40 degrees C was not effective when used alone, and did not enhance the effect of CDDP. However, combined use of it and OK-432 significantly enhanced the effect of CDDP.
Komatsu
K
K
Nakamura
W
W
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced; D008297:Male; D012515:Mast-Cell Sarcoma / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D010534:Peritoneal Neoplasms / Q000628:therapy*; D010844:Picibanil / Q000008:administration & dosage
D010844:Picibanil; D002945:Cisplatin