Aneurysm associated with chronic mucocutaneous candidiasis during long-term therapy with ketoconazole.
A little girl who was suffering from chronic mucocutaneous candidiasis also had a cellular immune deficiency and undetectable IgA levels. She was treated continuously for 6 years with ketoconazole at the same dosage of 200 mg/day. She was rapidly clear from infection and did not relapse although her immune abnormalities persisted. During this long-term therapy, voluminous fusiform intracranial aneurysm appeared, causing a paresis of the four limbs. Are they mycotic aneurysms?
Leroy
D
D
Service de Dermatologie, Centre Hospitalier Universitaire, Caen, France.
Dompmartin
A
A
Houtteville
J P
JP
Theron
J
J
D000328:Adult; D000785:Aneurysm, Infected / Q000209:etiology*; D002177:Candidiasis / Q000150:complications*; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004406:Dysgammaglobulinemia / Q000150:complications; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D002532:Intracranial Aneurysm / Q000209:etiology*; D007654:Ketoconazole / Q000008:administration & dosage*; D008134:Long-Term Care
D007654:Ketoconazole