title: [Methemoglobinemia after accidental Nestosyl ingestion].
abstract: Nestosyl is usually used for dental pain in children. We report a methemoglobinemia after accidental ingestion of 10 ml in a 2 year-old girl. Cyanosis was cleared and O2 saturation and PaO2 were normalized 15 mn after methylene blue (1 mg/kg) administered intravenously. Nestosyl contains butoform, benzocaine, resorcine and 8-hydroxyquinoleine: the 3 latest can induce methemoglobinemia. The benefit of the drug is not demonstrated and this potentially severe side effect justifies its delivery only after medical prescription and information about its dangers.
authors.affiliation: Services de Pharmacologie Clinique, Hôpital Bretonneau, Tours.
authors.forename: E
authors.initials: E
authors.lastname: Autret
authors.forename: E
authors.initials: E
authors.lastname: Forveille-Fournier
authors.forename: S
authors.initials: S
authors.lastname: Marchand
authors.forename: A P
authors.initials: AP
authors.lastname: Jonville
authors.forename: N
authors.initials: N
authors.lastname: Ramponi
mesh_terms: D000779:Anesthetics, Local / Q000506:poisoning*; D003490:Cyanosis / Q000209:etiology; D004338:Drug Combinations / Q000506:poisoning; D005260:Female; D006801:Humans; D006912:Hydroxyquinolines / Q000506:poisoning*; D007223:Infant; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000150:complications; D015125:Oxyquinoline / Q000506:poisoning*
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D006912:Hydroxyquinolines; D015125:Oxyquinoline; C030643:Nestosyl ointment
vernacular_title: Méthémoglobinémie après ingestion accidentelle de Nestosyl.