title: Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.
abstract: Serum concentrations of interferon-gamma were measured in individuals seropositive for human immunodeficiency virus type 1 (HIV-1). According to the CDC classification system, 6 presented with stage IV-C, 5 with stage IV-A, 8 with stage III, and the remaining 24 individuals with stage II. A modified radioimmunoassay procedure for detection of interferon-gamma was used with a detection limit of 18 U/L. Approximately one-half (22/43) of the seropositives exhibited increased serum interferon-gamma concentrations compared with seronegative blood donors (n = 76). There was a significant association between serum interferon-gamma concentrations and CDC stages of the patients; patients classified as CDC IV-C had the highest concentrations. Further, a significant positive correlation was observed between serum interferon-gamma and serum neopterin concentrations in seropositive study participants. We conclude that interferon-gamma is present in increased concentrations in HIV-1 seropositives compared to seronegative blood donors. Diminished in vitro production of interferon-gamma by T-lymphocytes on stimulation with specific soluble antigens contrasts with increased levels of circulating interferon-gamma in patients.
authors.affiliation: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: A
authors.initials: A
authors.lastname: Hausen
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: E R
authors.initials: ER
authors.lastname: Werner
authors.forename: G
authors.initials: G
authors.lastname: Werner-Felmayer
authors.forename: M P
authors.initials: MP
authors.lastname: Dierich
authors.forename: H
authors.initials: H
authors.lastname: Wachter
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D015497:HIV-1; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019798:Neopterin
chemical_list: D001708:Biopterins; D019798:Neopterin; D007371:Interferon-gamma