title: Myelofibrosis with myeloid metaplasia following essential thrombocythaemia.
abstract: We report a male patient in whom a diagnosis of essential thrombocythaemia was made at the age of 25. The clinical course was characterised by recurrent thrombotic episodes during the first few years of the disease, followed by a relatively benign course. He was treated with 32P, nitrogen mustard and plateletpheresis. A transformation into myelofibrosis with myeloid metaplasia was revealed 20 years after ET diagnosis. The length of the disease and the 32P therapy are discussed as factors favouring this metamorphosis.
authors.affiliation: Dipartimento di Medicina Internae e Terapia Medica, Sezione Clinica Medica II, IRCCS Policlinico S. Matteo, Pavia, Italia.
authors.forename: N L
authors.initials: NL
authors.lastname: Liberato
authors.forename: G
authors.initials: G
authors.lastname: Barosi
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: P
authors.initials: P
authors.lastname: D'Elia
authors.forename: P
authors.initials: P
authors.lastname: Boccaccio
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000209:etiology*; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000628:therapy; D013997:Time Factors