title: Production and induction of beta-lactamase during growth of Pseudomonas aeruginosa in biological fluids.
abstract: beta-Lactamase production in biological fluids was evaluated by using an antibiotic-resistant Pseudomonas aeruginosa strain. Enzyme production was low in plasma or ascitic fluid and high in urine. Induction of beta-lactamase by imipenem was studied by using an inducible P. aeruginosa strain. Induction was lower in biological fluids than in Mueller-Hinton broth.
authors.affiliation: Division of Microbiology and Infectious Diseases, Hôpital Saint-Luc, Montreal, Quebec, Canada.
authors.forename: E D
authors.initials: ED
authors.lastname: Letendre
authors.forename: P L
authors.initials: PL
authors.lastname: Turgeon
mesh_terms: D001202:Ascitic Fluid / Q000382:microbiology; D001437:Bacteriuria / Q000382:microbiology; D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D001618:beta-Lactamases