[Effect of glycerol trinitrate on R-amplitude in patients with chronic ischemic heart disease].
In 50 patients with angiographically proven coronary artery disease (CAD) and typical angina pectoris, and in 35 patients with normal angiographic findings the amplitudes of R-waves (sigma R) in 36 precordial ECG leads were measured before and after application of 0.8 mg glycerol trinitrate (GTN). In 21 patients the examination was repeated after coronary bypass surgery. In the CAD-patients decrease of sigma R was shown after sublingual GTN: 19.5 +/- 26.4 mm (p less than 0.05). The control group showed a slight increase of sigma R: 18.7 +/- 16.2 mm (p less than 0.05). After bypass surgery the decrease of sigma R after glycerol trinitrate could no longer be shown. These result support the hypothesis that glycerol trinitrate is capable of reducing enhanced R-amplitudes in resting ECG due to ischemia.
Teichmann
W
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Klinik und Poliklinik für Innere Medizin, Martin-Luther-Universität Halle/Saale.
D000787:Angina Pectoris / Q000188:drug therapy*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000188:drug therapy*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D005996:Nitroglycerin / Q000627:therapeutic use*; D012815:Signal Processing, Computer-Assisted
D005996:Nitroglycerin
Zum Einfluss von Glyceroltrinitrat auf die R-Amplitude bei Patienten mit chronisch ischämischer Herzkrankheit.