Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes.
Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.
Marinovich
M
M
Institute of Pharmacological Sciences, Univ. of Milan, Italy.
Flaminio
L M
LM
Papagni
M
M
Galli
C L
CL
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D011464:Epoprostenol / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D013929:Thromboxane B2; D002251:Carbon Tetrachloride; D011464:Epoprostenol; D001219:Aspartate Aminotransferases; D015232:Dinoprostone; D007213:Indomethacin