[Long-term administration of tegafur in postoperative adjuvant chemotherapy in gastric cancer patients. Serial analysis of serum tegafur and 5-fluorouracil concentrations, and influence from PSK combination].
We investigated the pharmacokinetics of long-term (2-year) daily oral administration of FT-207-E or UFT for postoperative adjuvant chemotherapy in 85 gastric cancer patients by measuring serum FT-207 and 5-FU concentration serially. There were no significant changes in serum FT-207.5-FU concentration during observation period between FT-207-E and UFT groups. There was different operative modality between partial gastrectomy (Billroth I) and total gastrectomy, but no significant difference in serum FT-207.5-FU concentration between the two groups, and no significant serial changes in serum FT-207.5-FU concentrations were observed in both groups. Conversion from FT-207 to 5-FU measured by serum concentration was not suppressed by combination with the biological response modifier PSK.
Tanaka
T
T
Dept. of Surgery, Fukui Red Cross Hospital.
Kitao
T
T
Furutani
M
M
Harada
T
T
Hayashi
S
S
Matsushita
T
T
Asada
I
I
Shirosaki
H
H
D000276:Adjuvants, Immunologic; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000097:blood; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors; D014498:Uracil / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; D005641:Tegafur; C010770:polysaccharide-K; D014498:Uracil; D005472:Fluorouracil