title: Etiopathogenesis of UVB stimulated calciuria in chronic gastrointestinal patients with decreased supply of vit. D.
abstract: It was stated that in patients with chronic gastrointestinal disorders (CGD) and decreased supply of Vit. D (25/OH/D = 6.8 +/- 3.0 ng/ml) during UVB stimulated skin synthesis of Vit.D the increment of Vit.D and 25-hydroxycholecalciferol (25/OH/D) depends on the starting values of Vit.D and 25/OH/D and is accompanied by significant increment of calciuria (delta mean UCa). Before the irradiation with UVB, mean 1,25/OH/2D in age paired healthy controls (50.66 +/- 12.35 pg/ml) when compared with CGD (47.62 +/- 12.08 pg/ml) and F.1,25/OH/2D in controls (2.02 +/- 0.80) and CGD (2.03 +/- 0.46) did not differ when mean PTH in CGD (135.3 +/- 61.6 pg/ml) was significantly higher in CGD (44.6 +/- 18.54 pg/ml, p less than 0.01) than in control group. During and after UVB irradiation completion of CGD mean 1,25/OH/2D levels (129.0 +/- +31.9 pg/ml) as well as F. 1,25/OH/2D index (5.54 +/- +1.54) were rising with the maximum reached on the 14-th day which was paralleled with a subsequent drop in mean PTH (72.3 +/- 24.42 pg/ml) concentration. The data indicated that UVB stimulated calciuria in CGD patients was correlated with increased synthesis of 1,25/OH/2D and increased F. 1,25/OH/2D index which was accompanied with suppression of mean PTH.
authors.forename: E
authors.initials: E
authors.lastname: Marcinowska-Suchowierska
authors.forename: R
authors.initials: R
authors.lastname: Lorenc
authors.forename: R
authors.initials: R
authors.lastname: Brzozowski
mesh_terms: D000328:Adult; D002118:Calcium / Q000652:urine*; D002908:Chronic Disease; D005260:Female; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D013997:Time Factors; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium