Previous experience disrupts d-amphetamine-induced stereotypic diving in rats.
Rats given d-amphetamine and placed in a tank of water repeatedly dive towards the bottom of the tank. Two experiments investigated this stereotypy. The first established a dose-response function for the stereotypy and the second showed that experience with the apparatus prior to drug administration disrupted the stereotypy. The latter result is consistent with the findings of previous work and thus provides a degree of generality for the role of experience interacting with CNS drugs to induce stereotypies.
Petree
A D
AD
Department of Psychology, Central Washington University, Ellensburg 98926.
DeVietti
T L
TL
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D003913:Dextroamphetamine