title: [The natural history and laboratory parameters of HIV infection].
abstract: Since 1983 the morbidity and mortality rates as well as results of haematological, immunological and (later) HIV serological tests were recorded prospectively for 497 HIV-positive patients during 1837 clinic visits at least twice within at most six months for a median period of observation of 18 months (range 6-64 months). The rate of progression to a higher stage was calculated according to the method of Kaplan-Meier. The rate for asymptomatic patients was 16% after one and 33% after two years; for patients with persisting generalized lymphadenopathy it was 13% and 21%, respectively, for those with AIDS-related complex 28% and 47%, respectively, and for those with AIDS 33% and 82%, respectively. As for results of laboratory tests, patients with progressive disease had significantly lower titres of anti-HIV nuclear antibodies, as well as a higher incidence of HIV-p24 antigen. Haemoglobin levels, platelet and lymphocyte counts and number of CD-4-positive lymphocytes were significantly lower, Neopterin and beta 2-microglobulins higher (P less than 0.01).
authors.affiliation: Abteilung für Infektionskrankheiten, Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: J
authors.initials: J
authors.lastname: Brühwiler
authors.forename: R
authors.initials: R
authors.lastname: Lüthy
authors.forename: H I
authors.initials: HI
authors.lastname: Joller-Jemelka
authors.forename: B
authors.initials: B
authors.lastname: Ledergerber
authors.forename: W
authors.initials: W
authors.lastname: Fierz
authors.forename: W
authors.initials: W
authors.lastname: Siegenthaler
authors.forename: P J
authors.initials: PJ
authors.lastname: Grob
mesh_terms: D000386:AIDS-Related Complex / Q000097:blood / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D001772:Blood Cell Count; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D019798:Neopterin; D011446:Prospective Studies; D012191:Retroviridae Proteins / Q000032:analysis; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D000974:Antibodies, Antinuclear; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D006454:Hemoglobins; D012191:Retroviridae Proteins; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin
vernacular_title: Spontanverlauf und Laborparameter bei HIV-Infektion.