Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick.
The metabolic effects of dietary boron, magnesium, and molybdenum on mineral metabolism in the cholecalciferol-deficient chick, with emphasis on growth cartilage histology, were studied. One-day-old cockerel chicks were assigned to groups in a fully-crossed, three factor, 2 x 2 x 2 design. The basal diet was based on ground corn, high-protein casein, and corn oil and contained 125 IU cholecalciferol (inadequate), 0.465 mg B, 2.500 mg Mg, and 0.420 mg Mo/kg. The treatments were the supplementation of the basal diet with B at O or 3; Mg at 300 (inadequate) or 500 (adequate); and Mo at 0 or 20 mg/kg. At d 25, B depressed mortality, alleviated the cholecalciferol-deficiency induced distortion of the marrow sprouts (MS) of the proximal tibial epiphysial plate, and elevated the numbers of osteoclasts within the MS. Adequate Mg exacerbated the cholecalciferol-deficiency induced bone lesions. Mo widened the MS markedly. In Mg-deficient chicks, B elevated plasma Ca and Mg concentrations and growth, but inhibited initiation of cartilage calcification; B had the opposite effect in Mg-adequate chicks. An interaction among B, Mg, and Mo affected plasma uric acid and glucose concentrations. B may function to modify mineral metabolism in cholecalciferol deficiency, suppressing bone anabolism in concurrent Mg deficiency and bone catabolism in concurrent Mg adequacy.
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US Department of Agriculture, Grand Forks Human Nutrition Research Center, ND 58202.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001853:Bone Marrow / Q000033:anatomy & histology / Q000378:metabolism; D001895:Boron / Q000494:pharmacology*; D002113:Calcification, Physiologic / Q000187:drug effects; D002356:Cartilage / Q000033:anatomy & histology / Q000378:metabolism; D002645:Chickens; D002762:Cholecalciferol / Q000172:deficiency*; D004032:Diet; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D008982:Molybdenum / Q000494:pharmacology*
D008903:Minerals; D002762:Cholecalciferol; D008982:Molybdenum; D008274:Magnesium; D001895:Boron