Increase in desipramine serum levels associated with methadone treatment.
Five men in a methadone treatment program who were also receiving desipramine had significantly higher desipramine serum levels when taking both drugs than when taking the antidepressant alone. Monitoring of desipramine serum levels may be useful with such patients.
Maany
I
I
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
Dhopesh
V
V
Arndt
I O
IO
Burke
W
W
Woody
G
G
O'Brien
C P
CP
D000328:Adult; D003042:Cocaine; D003891:Desipramine / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D009293:Opioid-Related Disorders / Q000097:blood / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000097:blood / Q000534:rehabilitation
D003042:Cocaine; D003891:Desipramine; D008691:Methadone