title: gamma-Acetylenic-gamma-aminobutyrate as an enzyme-activated inhibitor of D-amino acid transaminase.
abstract: Bacterial D-amino acid transaminase undergoes complete inactivation by gamma-acetylenic GABA. This inactivation is completely prevented by D-alanine and partially prevented by L-alanine. During inactivation the coenzyme portion of the enzyme undergoes significant spectral changes.
authors.affiliation: Rockefeller University, New York, NY 10021.
authors.forename: A
authors.initials: A
authors.lastname: Martinez del Pozo
authors.forename: H
authors.initials: H
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Merola
authors.forename: C
authors.initials: C
authors.lastname: Danzin
authors.forename: J M
authors.initials: JM
authors.lastname: Manning
mesh_terms: D000409:Alanine / Q000494:pharmacology; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology*; D001407:Bacillus / Q000201:enzymology; D051263:D-Alanine Transaminase; D013053:Spectrophotometry; D013379:Substrate Specificity; D013997:Time Factors; D000637:Transaminases / Q000037:antagonists & inhibitors*
chemical_list: D000480:Alkynes; D000614:Aminocaproates; C013785:4-amino-5-hexynoic acid; D000637:Transaminases; D051263:D-Alanine Transaminase; D000409:Alanine