Opposite effect of donor-specific immunization by blood or splenocytes on the survival of heart tissue transplants in strong versus weak histoincompatible combination in mice.
Recipients of allogeneic heart tissue were pretreated intravenously with blood or injected intraperitoneally with spleen cells. In H-2 incompatible donor-recipient combination (BALB/c----CBA/H) donor-specific immunization, both with blood and spleen cells, resulted in acceleration of graft rejection. On the other hand, increase in graft survival was observed following donor-specific but not third-party blood pretreatment in mice compatible in H-2 complex but bearing different minor histoincompatible antigens (BALB/c----DBA/2).
Lasek
W
W
Department of Transplantology, Institute of Biostructure, Medical School, Warsaw.
Jakóbisiak
M
M
Grochowska
M
M
Płodziszewska
M
M
Górecki
D
D
D000818:Animals; D001803:Blood Transfusion; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006183:H-2 Antigens; D016027:Heart Transplantation / Q000276:immunology*; D006648:Histocompatibility; D007114:Immunization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D006183:H-2 Antigens