title: Drug release rates from four sizes of a new transdermal nitroglycerin adhesive patch.
abstract: This study was conducted to determine the amount of nitroglycerin released from transdermal nitroglycerin patches of four different sizes: 3.3 cm2, 6.7 cm2, 13.3 cm2, and 20 cm2. Thirty healthy men received a single 24-hour application of each patch size according to a randomized, open-label, four-period crossover design. A 24-hour interval separated each treatment period. The total amount of nitroglycerin released by the four patches was proportional to size. All four patch sizes released nitroglycerin at a comparable rate. The mean overall 24-hour release rate of 0.76 mg/cm2 was similar to the release rate of 0.75 mg/cm2/24 hr observed in a previous study. Adverse experiences common to nitroglycerin administration were reported for all patch sizes, with headache, light-headedness, and nausea reported most frequently.
authors.affiliation: 3M Riker, 3M Health Care Group, St. Paul, Minnesota.
authors.forename: D J
authors.initials: DJ
authors.lastname: Riedel
authors.forename: K A
authors.initials: KA
authors.lastname: Wick
authors.forename: R W
authors.initials: RW
authors.lastname: Hawkinson
authors.forename: C A
authors.initials: CA
authors.lastname: Kolars
authors.forename: J K
authors.initials: JK
authors.lastname: Crowley
authors.forename: L I
authors.initials: LI
authors.lastname: Harrison
authors.forename: S R
authors.initials: SR
authors.lastname: de Dennis
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000009:adverse effects; D012867:Skin / Q000187:drug effects
chemical_list: D005996:Nitroglycerin