The effect of dietary mercury on vanadate toxicity in the chick.
Three experiments were conducted investigating the interaction of dietary vanadate and mercury on the growth of chicks. The growth-retarding effect of 30 mg vanadium/kg diet was completely overcome by the inclusion of 500 mg mercury/kg diet. Restricting the feed intake of the mercury-supplemented animals to approximately those receiving vanadate alone still resulted in an amelioration of the growth retarding effect of vanadate. Analyses of femurs and kidneys revealed that mercury added to a vanadium-containing diet increased the vanadate concentration of the femur and had no effect on the vanadium concentration in the kidney. As little as 25 mg mercury/kg diet significantly reduced the growth retarding effect of vanadium. The inclusion of 100 mg mercury/kg in the diet resulted in a significant increase in renal glutathione concentration.
Hill
C H
CH
Department of Poultry Science, North Carolina State University, Raleigh 27695-7635.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000032:analysis; D002645:Chickens; D004032:Diet; D004435:Eating / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D008628:Mercury / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution; D014638:Vanadates / Q000633:toxicity*; D014639:Vanadium / Q000032:analysis
D014639:Vanadium; D014638:Vanadates; D008628:Mercury; D005978:Glutathione