Role of vascular decongestion in ischemic acute renal failure defined by postinsult administration of pentoxifylline.
The patholophysiologic significance of vascular congestion in the mechanism of ischemic acute renal failure following postocclusive reflow was studied with a novel hemorheologic probe, pentoxifylline. Using the autoperfused rat kidney model, inulin clearances (CIN), urine flow rates (UFR), renal electrolyte excretions, and renal hemodynamic parameters (RVR, RBP, RBF) were compared in saline- and pentoxifylline-treated anesthetized rats prior to and following a 45-min occlusive period. Renal functional and hemodynamic parameters were significantly altered in saline controls. In contrast, postischemia treatment with pentoxifylline was associated with significant recovery in CIN and UFR, and stable RVR, RBF, and RBP. Kidneys treated with saline infusion had pronounced vascular congestion, in contrast to those administered pentoxifylline. Coupled with the absence in medullary hyperemia, the present experiments support the role of vascular congestion in ischemic acute renal failure. Pentoxifylline, administered in pharmacologic doses after the insult, provided benefit during the initiation phase of postischemic acute renal failure. These data strengthen the opinion that ischemic insult results in vascular congestion, and that restoration of blood flow will prevent further deterioration in renal function.
Luke
D R
DR
Department of Pharmaceutics, University of Houston, Texas Medical Center.
Berens
K L
KL
Verani
R R
RR
D058186:Acute Kidney Injury / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats
D010431:Pentoxifylline