Marked elevation and cyclic variation of corticosteroid-binding globulin: an inherited abnormality?
Unexplained high serum corticosteroid-binding globulin (CBG) concentrations [mean values, 78.8 and 55.7 mg/L; normal women, 38.8 +/- 3.8 (+/- SD) mg/L] were found repeatedly in two apparently healthy sisters who were not pregnant or taking exogenous estrogens. One had substantial variations in serum CBG and sex hormone-binding globulin concentrations during the menstrual cycle, which paralleled the normal cyclic changes in serum estradiol. The other woman was postmenopausal and had a high serum CBG concentration despite of low serum estradiol levels. We conclude those women have an inherited abnormality in CBG production.
Coolens
J L
JL
Department of Endocrinology and Isotopes, Salvatorziekenhuis, Hasselt, Belgium.
Heyns
W
W
D000328:Adult; D002648:Child; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008597:Menstrual Cycle; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014156:Transcortin / Q000032:analysis* / Q000502:physiology; D014809:Vitamin D-Binding Protein / Q000032:analysis
D012738:Sex Hormone-Binding Globulin; D013975:Thyroxine-Binding Proteins; D014809:Vitamin D-Binding Protein; D014156:Transcortin