Induction of the SOS response in Escherichia coli by heavy ions.
The effectiveness of heavy ions in inducing the SOS response in E. coli cells has been measured by means of the SOS-chromotest. The SOS induction potency of ionizing radiation increases with increasing LET, to 40-60 keV/microns, reaches a maximum and then decreases at greater LET values. We conclude that the SOS-inducing damages in the case of ionizing radiation could be DNA injuries of a 'complex' type, e.g., DNA double-strand breaks or some kind of heavily damaged single-strand lesions.
Kozubek
S
S
Joint Institute for Nuclear Research, Dubna, U.S.S.R.
Krasavin
E A
EA
Soska
I
I
Drasil
V
V
Amirtayev
K G
KG
Tokarova
B
B
Bonev
M
M
D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D004260:DNA Repair / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000528:radiation effects; D005720:Gamma Rays; D005798:Genes, Bacterial; D007700:Kinetics; D013014:SOS Response, Genetics / Q000528:radiation effects*; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism
D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D000469:Alkaline Phosphatase; D001616:beta-Galactosidase