title: Extracorporeal complexation and haemodialysis for the treatment of cadmium poisoning. I. Effects of four chelators on the in vitro elimination of cadmium from human blood.
abstract: The effect of ethylenediamine tetraacetic acid (EDTA), glutathione (GSH), citrate and 2,3-dimercaptosuccinic acid (DMSA) on the elimination of cadmium (Cd) from human blood, by complexing haemodialysis, was investigated in vitro. A significant increase in elimination rate was observed with all four chelators compared to that observed without chelators. EDTA was found to be the most effective agent, which at a level of 0.01M in the dialysate facilitated elimination of 80% of the blood Cd originally present.
authors.affiliation: Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Sheabar
authors.forename: S
authors.initials: S
authors.lastname: Yannai
mesh_terms: D001773:Blood Cells / Q000378:metabolism; D002104:Cadmium / Q000097:blood*; D002105:Cadmium Poisoning / Q000628:therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D004492:Edetic Acid / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D002614:Chelating Agents; D002104:Cadmium; D004492:Edetic Acid; D005978:Glutathione