[Synthesis of N-N-di(2-dibromoethyl)hydrazides of natural alpha-aminocarboxylic acids].
In the course of a systematical studies on halogenoethylhydrazides of natural alpha-aminocarboxylic acids and their derivatives, N,N-di(2-bromoethyl)hydrazides of glycine, valine, lysine, phenylalanine, L- and D,L-alanine, leucine, isoleucine and cystine were synthesized. It was shown that N,N-di(2-bromoethyl)hydrazides of amino acids with deblocked amino groups are comparatively toxic and unstable, while the N alpha-protected compounds are stable, nontoxic even at a dose of 625 mg/kg and with a high antitumour effect: 70-92% suppression of tumour growth at a dose of 75 mg/kg.
Loseva
S
S
Institut für Molekularbiologie der Bulgarischen Akademie der Wissenschaften, Sofia.
Zakhariev
S
S
Stoev
S
S
Taksirov
S
S
Golovinsky
E
E
D000236:Adenoma / Q000188:drug therapy; D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000596:Amino Acids; D000970:Antineoplastic Agents; D006834:Hydrazines
Synthese von N,N-Di(2-bromethyl)hydraziden einiger natüricher alpha-Aminocarbonsäuren.