title: Characterization of a polymorphism in the 3' part of the chicken vitellogenin gene.
abstract: An allele giving rise to a polymorphism within the 3' part of the chicken vitellogenin gene was cloned, sequenced, and compared to the previously cloned allele. The polymorphism is formed by a perfect copy of 343 bp from intron 32 in tandem array with a perfect copy of 244 bp from intron 33; this 587-bp element is inserted in a head-to-tail arrangement in intron 33. We propose a mechanism in which an unequal crossing-over resulted in a vitellogenin gene with two exons 33, one of which was subsequently deleted. Thus, intron 33 was enlarged by the tandem repeats without affecting the protein-encoding sequence of the gene. At the boundaries of the repeated elements, two short direct repeats are found that resemble the recombination signals of immunoglobulin genes. They may have had a key role in the formation of the new allele.
authors.affiliation: Laboratory of Biochemistry, Groningen, The Netherlands.
authors.forename: J N
authors.initials: JN
authors.lastname: Philipsen
authors.forename: J E
authors.initials: JE
authors.lastname: de Vries
authors.forename: J
authors.initials: J
authors.lastname: Samallo
authors.forename: C
authors.initials: C
authors.lastname: van Dijk
authors.forename: A C
authors.initials: AC
authors.lastname: Arnberg
authors.forename: G
authors.initials: G
authors.lastname: AB
mesh_terms: D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics*; D005796:Genes; D007438:Introns; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D015183:Restriction Mapping; D014819:Vitellogenins / Q000235:genetics*
chemical_list: D014819:Vitellogenins