Ceroidogenic effect of ionizing radiation.
The effect of the exposure of Torpedo marmorata to a single dose of 400 cGy of ionizing radiation and doses of 200 cGy/week for 4 weeks has been studied. The parameters measured were the TBA reactivity and lipofuscin production, a fluorescent pigment that is thought to derive from the reaction of malonaldehyde, a peroxide-degradation product, with free amino-groups. Acute irradiation was found to generate an increase of peroxidative damage in some tissues. This effect was inhibited by acetyl homocysteine-thiolactone, a drug that increases the activity of tissue superoxide dismutase. Chronic irradiation produces a severe increase in the generation of lipofuscin.
Pisanti
F A
FA
Stazione Zoologica, Napoli, Italy.
Lucadamo
L
L
Aloj Totaro
E
E
D000818:Animals; D002566:Ceroid / Q000096:biosynthesis*; D005260:Female; D016166:Free Radical Scavengers; D008062:Lipofuscin / Q000096:biosynthesis; D008297:Male; D011839:Radiation, Ionizing; D013858:Thiobarbiturates; D013876:Thiophenes / Q000494:pharmacology; D014101:Torpedo
D002566:Ceroid; D016166:Free Radical Scavengers; D008062:Lipofuscin; D013858:Thiobarbiturates; D013876:Thiophenes; C000486:citiolone; C029684:thiobarbituric acid