Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency.
In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.
Günther
T
T
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, FRG.
Rebentisch
E
E
Vormann
J
J
König
M
M
Ising
H
H
D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006311:Hearing Disorders / Q000139:chemically induced*; D008275:Magnesium Deficiency / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000633:toxicity*; D020156:Salicylic Acid; D015032:Zinc / Q000172:deficiency*
D005839:Gentamicins; D012459:Salicylates; D015032:Zinc; D020156:Salicylic Acid