title: Postnatal development of pancreatic alpha-amylase and intestinal saccharase and lactase in rat sucklings as related to thyroid function of mothers.
abstract: The treatment of lactating mothers with 50 micrograms/100 g b.w. thyroxine s.c. daily from the 1st to 21st day of lactation resulted in earlier induction of alpha-glucosidases (pancreatic alpha-amylase, intestinal saccharase) and in earlier repression of beta-galactosidases (intestinal lactase). In contrast, the sucklings fed by thyroidectomized mothers showed a delayed induction of pancreatic alpha-amylolytic activity and intestinal saccharase, but ameliorated the repression of lactase. The treatment of another group of thyroidectomized mothers with 5 micrograms/100 g b.w. thyroxine prevented such effects mothers of thyroidectomy in sucklings.
authors.affiliation: Institute of Biochemistry, Academy of Sciences, UzSSR Tashkent.
authors.forename: J C
authors.initials: JC
authors.lastname: Turakulov
authors.forename: K R
authors.initials: KR
authors.lastname: Rakhimov
authors.forename: S F
authors.initials: SF
authors.lastname: Karimova
authors.forename: L S
authors.initials: LS
authors.lastname: Kuchkarova
mesh_terms: D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001835:Body Weight; D004790:Enzyme Induction; D005260:Female; D005696:Galactosidases / Q000096:biosynthesis*; D007419:Intestinal Secretions / Q000201:enzymology; D007774:Lactation; D009929:Organ Size; D010179:Pancreas / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013393:Sucrase / Q000096:biosynthesis*; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology; D000516:alpha-Amylases / Q000096:biosynthesis*; D001616:beta-Galactosidase / Q000096:biosynthesis*
chemical_list: D005696:Galactosidases; D000516:alpha-Amylases; D001616:beta-Galactosidase; D013393:Sucrase; D013974:Thyroxine