[Effect of bromocriptine and bromocriptine combined with prolactin on the proliferation of thymocytes in young rats].
The effects of bromocriptine and bromocriptine associated to prolactin have been investigated on young rat thymocytes after sensitization with T-cell antigen SRBC using a quantitative nucleus image analysis (Samba 200). Bromocriptine alone induces an inhibition of lymphocyte proliferation, a chromatin condensation and enhances cell differentiation. These effects are reversed by prolactin, which therefore acts on lymphocytes before they leave the thymus.
Aboussaouira
T
T
Equipe Hormones et Immunité, Université Joseph-Fourier, Grenoble.
Marie
C
C
Idelman
S
S
D000818:Animals; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure; D004338:Drug Combinations; D005260:Female; D005434:Flow Cytometry; D011388:Prolactin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000166:cytology* / Q000648:ultrastructure
D002843:Chromatin; D004338:Drug Combinations; D001971:Bromocriptine; D011388:Prolactin
Action de la bromocryptine et de la bromocryptine associée à la prolactine sur la prolifération des thymocytes de jeune rat.