title: [Comparative study of the bronchodilator effect of inhaled fenoterol and aerosol salbutamol in patients with chronic bronchial asthma].
abstract: The bronchodilator effects of inhaled fenoterol (FI) and salbutamol aerosol (S) in 15 patients (8 male and 7 female with a median age of 44 +/- 13 years), diagnosed as suffering from asthma, were studied using spirometry (determining FEV1, FEF 25-75% and FVC) and flow volume curves (PEF, MEF 75% and MEF 25%). The mean theroric rate of FEV1, PEF, MEF 75% was defined as the theoric rate of the obstruction of central airways (PCA%) and the mean of FVC, FEF 25-75% and MEF 25% rates defined as the rate of the theoric obstruction of the peripheral airways (PPA%). Basal and 5, 15, 30, 60, 120, 240, 360, 480 minute determinations were done, after the administration of 200 mcg of S in the conventional way on two different days. The statistic study carried out using the "u" test of Mann-Whytney. No statistically significant differences in intensity, onset nor duration of the effect between both drugs were found. We concluded that FI is a drug of great utility in treatment of asthmatic patients and one which allowed, because of the easy inhaling technique, the use of beta 2 adrenergic drugs in a mayor number of patients who would otherwise have to resort to an alternative form of administration.
authors.forename: L
authors.initials: L
authors.lastname: Valdés Cuadrado
authors.forename: M
authors.initials: M
authors.lastname: Salgueiro Rodriguez
authors.forename: P
authors.initials: P
authors.lastname: Alvarez-Calderón Prat
authors.forename: M R
authors.initials: MR
authors.lastname: Arias Castells
authors.forename: M
authors.initials: M
authors.lastname: Berdugo Oviedo
authors.forename: R
authors.initials: R
authors.lastname: Rabuñal Rey
authors.forename: J
authors.initials: J
authors.lastname: Ventosa Rial
authors.forename: J R
authors.initials: JR
authors.lastname: Rodríguez Suarez
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000336:Aerosols; D005280:Fenoterol; D000420:Albuterol
vernacular_title: Estudio comparativo del efecto broncodilatador entre fenoterol inhaletas y salbutamol aerosol en pacientes con asma bronquial crónica.