Effect of short-acting nitroglycerin on heart rate: evaluation by a self-monitoring device.
The efficacy of two sublingual nitroglycerin formulations was compared in 10 healthy subjects and 10 patients with ischaemic heart disease. A new microcomputerized device was used to record and analyze heart rate. The rise in heart rate began 1-1.5 min after administration of nitroglycerin tablets and was maximal within 3 min. The effect was more rapid with a quickly dissolving compound. The recording equipment was reliable, simple to use and inexpensive.
Lahtela
J T
JT
Department of Internal Medicine, University of Oulu, Finland.
Sotaniemi
E A
EA
D000286:Administration, Sublingual; D000328:Adult; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D012995:Solubility
D005996:Nitroglycerin