[Growth hormone in females with liver cirrhosis].
The median plasma concentration of growth hormone (GH) in 63 women with liver cirrhosis was significantly elevated when compared with a control group (4.4 ng/ml vs 1.8 ng/ml, p less than 0.01). In 38% of the patients GH concentration was higher than 6.0 ng/ml. GH correlated significantly with the degree of decompensation of the cirrhosis (Child A-C). It was not influenced by the concentrations of estradiol, estrone, or testosterone. Thyrotropin releasing hormone (TRH) induced paradoxial GH increase (delta-GH) in 23 patients showed no significant difference to the data of the control group (2.7 ng/ml vs 0.8 ng/ml). The etiology of cirrhosis (alcoholic or non alcoholic) proved to be unimportant concerning the GH elevation. A missing correlation of GH to thyroid stimulating hormone (TSH), and of delta-GH to TRH induced increase of TSH (delta-TSH) argues against the hypothesis that latent hypothyroidism - often described in cirrhosis - might be responsible of the GH elevation.
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Medizinische Klinik am Prosper-Hospital Recklinghausen.
D000328:Adult; D000368:Aged; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006509:Hepatitis B / Q000097:blood; D006527:Hepatolenticular Degeneration / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008105:Liver Cirrhosis, Biliary / Q000097:blood; D008875:Middle Aged; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013006:Growth Hormone
Wachstumshormon bei Frauen mit Leberzirrhose.