Production and some properties of monoclonal antibodies against serotype strains of Pseudomonas aeruginosa.
A set of 16 serotype specific monoclonal antibodies (MoAbs) against Pseudomonas aeruginosa classified by Homma were obtained by the mouse hybridoma technique. This set of MoAbs was useful for classification of their serotypes especially O-antigen groups G and M. MoAb obtained from serotype 15 of Homma's classification reacted with serotype 17 of the same classification. We also obtained two MoAbs which reacted with 7 Homma's serotypes of 6 different O-antigen groups and one MoAb which recognized all 4 Homma's serotypes of O-antigen group B. These MoAbs were also useful in mice for the preventive effect against the infections of P. aeruginosa.
Yoshida
K
K
Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Kawasaki-shi, Japan.
Kimura
F
F
Uchida
K
K
Kawaharajo
K
K
Koizumi
N
N
Nakajima
S
S
Nagaoka
K
K
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology / Q000627:therapeutic use; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011552:Pseudomonas Infections / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000145:classification*; D012703:Serotyping
D000906:Antibodies; D000911:Antibodies, Monoclonal