Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.
Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.
Sharp
F R
FR
Department of Neurology, University of California, San Francisco 94121.
Gonzalez
M F
MF
Hisanaga
K
K
Mobley
W C
WC
Sagar
S M
SM
D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects*; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism* / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes; D051381:Rats; D011919:Rats, Inbred Strains
D009414:Nerve Growth Factors; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos