Impact of nonlethal levels of Metacid-50 and carbaryl on thyroid function and cholinergic system of Channa punctatus.
With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine (T3) and thyroxine (T4) profiles, a biphasic response pattern was elicited in Channa punctatus chronically exposed to nonlethal doses of locally used pesticides, namely, Metacid-50 and Carbaryl. Data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesterase activity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholine accumulation and T3 level. It is surmised that Metacid-50 and Carbaryl influence both neural and hormonal functions.
Ghosh
P
P
Department of Zoology, Visva-Bharati University, West Bengal, India.
Bhattacharya
S
S
Bhattacharya
S
S
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D012721:Carbaryl / Q000633:toxicity*; D005399:Fishes / Q000378:metabolism*; D008743:Methyl Parathion / Q000633:toxicity*; D010278:Parathion / Q000031:analogs & derivatives*; D011863:Radioimmunoassay; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D008743:Methyl Parathion; D010278:Parathion; D000110:Acetylcholinesterase; D000109:Acetylcholine; D013974:Thyroxine; D012721:Carbaryl