title: Gd-DTPA-enhanced MR of suspected spinal multiple sclerosis.
abstract: A prospective study was undertaken to evaluate the potential of Gd-DTPA-enhanced MR to differentiate active from inactive demyelinating lesions of the cervical spinal cord. Five patients with elongated high-signal-intensity lesions in the cervical cord on long TR/TE spin-echo MR images and a clinical suspicion of demyelinating disease had MR before and after IV Gd-DTPA. Delayed contrast enhancement (after 45-60 min) of the lesions was seen on short TR/TE images in two patients with clinically active disease, but no enhancement could be detected in three patients with stable disease. The patients with active disease underwent repeated MR examinations until the enhancement disappeared. The decrease in Gd-DTPA enhancement paralleled a decrease in clinical signs and symptoms of cervical myelopathy. MR is useful in evaluating patients suspected of having demyelinating disease. The MR finding of asymptomatic lesions in the brain lends support to the diagnosis of multiple sclerosis. Other possible causes of myelopathy, such as spinal cord compression and intramedullary tumor, can be excluded with the use of MR.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
authors.forename: E M
authors.initials: EM
authors.lastname: Larsson
authors.forename: S
authors.initials: S
authors.lastname: Holtås
authors.forename: O
authors.initials: O
authors.lastname: Nilsson
mesh_terms: D000208:Acute Disease; D000328:Adult; D001284:Atrophy; D003287:Contrast Media; D003711:Demyelinating Diseases / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA