title: Genetic engineering of factor VIII.
abstract: Genetic manipulation of mammalian cells has provided a means of producing unlimited quantities of a high purity, virus-free preparation of factor VIII--the most complex protein manufactured through rDNA technology to date.
authors.affiliation: Cellular Genetics, Genetics Institute, Cambridge, Massachusetts 02140.
authors.forename: R J
authors.initials: RJ
authors.lastname: Kaufman
mesh_terms: D002460:Cell Line; D005169:Factor VIII / Q000235:genetics*; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans
chemical_list: D005169:Factor VIII