title: [Lipoxin B, an enhancing factor of spontaneous platelet aggregation in whole blood].
abstract: The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation.
authors.forename: A L
authors.initials: AL
authors.lastname: Khshivo
authors.forename: A S
authors.initials: AS
authors.lastname: Nekrasov
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kholodov
authors.forename: A M
authors.initials: AM
authors.lastname: Vikhert
authors.forename: G K
authors.initials: GK
authors.lastname: Popov
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D006893:Hydroxyeicosatetraenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D044045:Lipoxins; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D044045:Lipoxins; D016718:Arachidonic Acid; C034922:5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid; C042651:lipoxin B4
vernacular_title: Lipoksin B--faktor usileniia spontannoĭ agregatsii trombotsitov v tsel'noĭ krovi.