[Effects of conditioned media of rat pleural mesothelial cells, transformed in vivo or in vitro by asbestos, on the proliferation of normal mesothelial cells. Comparison with epidermal growth factor, EGF].
The effect of conditioned media obtained from in vivo or in vitro asbestos-transformed rat pleural mesothelial cells on growth of normal mesothelial cells was studied. It was found that both conditioned media led to a reduction of cell proliferation as shown by a decrease in the following parameters: cell number, tritiated thymidine incorporation and percentages of S cells. Similar effects were obtained with EGF (Epidermal Growth Factor).
Van der Meeren
A
A
I.N.S.E.R.M. U 139, C.H.U. Henri-Mondor, Créteil.
Levy
F
F
Katz
A
A
Renier
A
A
Jaurand
M C
MC
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003470:Culture Media / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D010994:Pleura / Q000032:analysis / Q000166:cytology*; D051381:Rats; D013936:Thymidine / Q000032:analysis
D003470:Culture Media; D001194:Asbestos; D004815:Epidermal Growth Factor; D013936:Thymidine
Effets de milieux conditionnés de cellules mésothéliales pleurales de rat, transformées in vivo ou in vitro par l'amiante, sur la prolifération des cellules mésothéliales normales. Comparaison avec le facteur de croissance épidermique, EGF.