title: Strain dependent response of circadian rhythms during exposure to continuous illumination.
abstract: Enzymes activities were measured, at three hours intervals, during 30 hours, in various tissues of C57BL/6J and A/J male mice. The measurements, were carried out on mice which were exposed for two, five and twenty one days to continuous illumination. Identical measurements were performed also on mice which were kept in alternating 14 hours light: 10 hours dark. Activity patterns of each group were analysed to test the presence, or absence, of rhythm characteristics. The results of the experiments with C57BL/6J have been previously reported. The comparison of the results, which were obtained from the two strains revealed that under exposure to alternating light: dark conditions all activity patterns exhibited a significant circadian rhythm. Except for one enzyme (thymus GAPD), the times of peak activity (acrophase) were identical for all other examined enzymes, in both strains. On the other hand when the two strains were exposed to continuous illumination they differed in their response to the effect of continuous light. The activity of the same enzyme exhibited different periodicity and/or different acrophase in each of the two strains. This variability reflects the existence of genetic differences, between the strains in the free running behavior of these enzymes' activity rhythms.
authors.affiliation: Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Peleg
authors.forename: M N
authors.initials: MN
authors.lastname: Nesbitt
authors.forename: I E
authors.initials: IE
authors.lastname: Ashkenazi
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004798:Enzymes / Q000235:genetics / Q000378:metabolism*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008029:Lighting; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D013045:Species Specificity
chemical_list: D004798:Enzymes; D007521:Isocitrate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D011683:Purine-Nucleoside Phosphorylase; D005956:Glucose-6-Phosphate Isomerase