The effect of aging on fracture healing in the rat.
The effect of age on the biomechanical properties of healing tibial fractures was studied by comparing the fracture healing in 2-year-old male Wistar rats with the fracture healing in 3-month-old male Wistar rats after 40 and 80 days of healing. There were no significant differences in the mechanical parameters after 40 days of healing, but after 80 days, a considerable delay in the fracture healing process was noted in the old rats compared with the young adult rats when evaluated by maximum load, maximum stress, stiffness, and energy absorption in a three-point bending procedure. In the contralateral, nonfractured bones, the tibiae from the old animals sustained higher loads and had higher stiffness than the bones from the young adult animals, but stress values, elastic modulus, and capacity for energy absorption was much lower in the old animals.
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Department of Connective Tissue Biology, University of Aarhus, Denmark.
Andreassen
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D000375:Aging / Q000502:physiology*; D000818:Animals; D050723:Fractures, Bone / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013977:Tibia / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology