Extracorporeal complexation and haemodialysis for the treatment of cadmium poisoning. I. Effects of four chelators on the in vitro elimination of cadmium from human blood.
The effect of ethylenediamine tetraacetic acid (EDTA), glutathione (GSH), citrate and 2,3-dimercaptosuccinic acid (DMSA) on the elimination of cadmium (Cd) from human blood, by complexing haemodialysis, was investigated in vitro. A significant increase in elimination rate was observed with all four chelators compared to that observed without chelators. EDTA was found to be the most effective agent, which at a level of 0.01M in the dialysate facilitated elimination of 80% of the blood Cd originally present.
Sheabar
F Z
FZ
Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa.
Yannai
S
S
D001773:Blood Cells / Q000378:metabolism; D002104:Cadmium / Q000097:blood*; D002105:Cadmium Poisoning / Q000628:therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D004492:Edetic Acid / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006435:Renal Dialysis; D013997:Time Factors
D002614:Chelating Agents; D002104:Cadmium; D004492:Edetic Acid; D005978:Glutathione