title: Restituted gastric mucosa: tolerance against low luminal pH and restricted mucosal blood flow in the cat.
abstract: This study examined the tolerance of gastric surface epithelium allowed to restitute for 90 min after damage produced by mucosal exposure to 2 M NaCl for 10 min. Cats were subjected to gastric luminal perfusion with saline at pH = 1.0 and reduction of celiac artery blood flow for 90 min. A flow reduction of 55%, as assessed by Doppler ultrasound flowmetry, was obtained by constriction of the celiac artery. These interventions alone did not produce lesions in nondamaged control cats, whereas exposure to 2 M NaCl immediately before flow reduction evoked extensive erosions as judged by gross examination and microscopy. Stomachs exposed to 2 M NaCl 90 min before flow reduction showed lesions that were clearly less in extent and number than in animals in which an intervening restitution period was not allowed. Topical dimethyl-prostaglandin E2 (50 micrograms/kg) increased the rate by which restituted surface cells were transformed to apparently normal cells. This study shows that the restituted gastric mucosa possesses a remarkably high tolerance against lowered blood flow in the presence of high luminal acidity.
authors.affiliation: Department of Surgery, University of Bergen, Norway.
authors.forename: J E
authors.initials: JE
authors.lastname: Grönbech
authors.forename: J E
authors.initials: JE
authors.lastname: Varhaug
authors.forename: K
authors.initials: K
authors.lastname: Svanes
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure; D002021:Buffers; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D002445:Celiac Artery / Q000502:physiology; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D008102:Liver Circulation / Q000187:drug effects; D008564:Membrane Potentials; D010100:Oxygen / Q000097:blood; D010710:Phosphates / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012462:Saline Solution, Hypertonic; D013154:Spleen / Q000098:blood supply
chemical_list: D001639:Bicarbonates; D002021:Buffers; D010710:Phosphates; D012462:Saline Solution, Hypertonic; D002245:Carbon Dioxide; D015064:16,16-Dimethylprostaglandin E2; D010100:Oxygen