Deprenyl suppresses the oxidant stress associated with increased dopamine turnover.
Tissue glutathione disulfide (GSSG) was studied as an index of changes in redox state in the striatum. When increased turnover of dopamine was provoked in mice by injection of haloperidol (1 mg/kg), the concentration of GSSG in the striatum tripled. Deprenyl (2.5 mg/kg) suppressed the rise in GSSG by 71.9%. These results indicate that deprenyl suppresses an oxidant stress associated with increased dopamine turnover.
Cohen
G
G
Department of Neurology, Mount Sinai School of Medicine, City University of New York, NY 10029.
Spina
M B
MB
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D010627:Phenethylamines; D012642:Selegiline; D008995:Monoamine Oxidase; D005978:Glutathione; D006220:Haloperidol; D019803:Glutathione Disulfide; D004298:Dopamine