title: The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (Callithrix jacchus).
abstract: Marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. Although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (ICDH), only the isoenzyme analysis of ICDH can differentiate definitely between liver and muscle damage. Only very severe muscle damage can increase the plasma concentration of this enzyme but, in this case, the elevation of plasma creatinine kinase levels helps differentiation. It is recommended that the elevation of ICDH is the most specific indicator of hepatic damage in the marmoset.
authors.affiliation: Roche Products Limited, Welwyn Garden City, Herts, U.K.
authors.forename: C W
authors.initials: CW
authors.lastname: Davy
authors.forename: M
authors.initials: M
authors.lastname: Fulleylove
authors.forename: J G
authors.initials: JG
authors.lastname: Edmunds
authors.forename: D A
authors.initials: DA
authors.lastname: Eichler
authors.forename: B
authors.initials: B
authors.lastname: Rushton
authors.forename: R J
authors.initials: RJ
authors.lastname: Tudor
authors.forename: J M
authors.initials: JM
authors.lastname: Walker
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000594:Amino Acid Oxidoreductases / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002144:Callithrix / Q000097:blood; D002143:Callitrichinae / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002746:Chlorpromazine / Q000633:toxicity*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D005969:Glutamate Dehydrogenase / Q000097:blood; D007521:Isocitrate Dehydrogenase / Q000097:blood* / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D009132:Muscles / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D009336:Necrosis
chemical_list: D007527:Isoenzymes; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D000594:Amino Acid Oxidoreductases; C025745:aspartate dehydrogenase; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D002746:Chlorpromazine