Modulation of melanocytic activity by acetylcholine.
Acetylcholine esterase (AChE) activity is lowered in vitiliginous skin. The AChE activity in 52 cases of vitiligo during repigmentation and depigmentation has been observed in this study. The cases with marginal dendritic melanocytes show that AChE is negative in these cells during depigmentation but positive on repigmentation. There is little variation in activity in the cases showing nondendritic marginal melanocytes. Acetylcholine (ACh) has an inhibitory effect on dopa oxidase activity in both types of marginal melanocytes in vitiligo. ACh modulates pigment production by the melanocytes, its role being inhibitory. From the present results, it is evident that a fall in AChE activity in the melanocytes leads to greater inhibition by ACh aggravating the process of depigmentation in vitiligo.
Iyengar
B
B
Institute of Pathology-ICMR, Safdarjang Hospital, New Delhi, India.
D000109:Acetylcholine / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000172:deficiency*; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D004837:Epinephrine / Q000502:physiology; D006801:Humans; D008544:Melanocytes / Q000187:drug effects* / Q000201:enzymology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D012880:Skin Pigmentation; D014820:Vitiligo / Q000145:classification / Q000201:enzymology / Q000473:pathology*
D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; D000110:Acetylcholinesterase; D000109:Acetylcholine; D004837:Epinephrine