title: Fluid flow and plaque formation in an aortic bifurcation.
abstract: Considering steady laminar flow in a two-dimensional symmetric branching channel with local occlusions, a finite element model has been developed to study velocity fields including reverse flow regions, pressure profiles and wall shear stress distributions for different Reynolds numbers, bifurcation angles and lumen reductions. The flow analysis has been extended to include a new submodel for the pseudo-transient formation of plaque at sites and deposition rates defined by the physical characteristics of the flow. Specifically, simulating the onset of atherosclerotic lesions, sinusoidal plaque layers have been placed in areas of critically low wall shear stresses, and simulating the growth of particle depositions, plaque layers have been added in a stepwise fashion in regions of critically high and low shear. Thus two somewhat conflicting hypothetical correlations between critical wall shear stress levels and atheroma have been tested and a solution has been postulated. The validated computer simulation model is a predictive tool for analyzing the effects of local changes in wall curvature due to surgical reconstruction and/or atherosclerotic lesions, and for investigating the design of aortic bifurcations which mitigate plaque formation.
authors.affiliation: Department of Mechanical and Aerospace Engineering, N.C. State University, Raleigh 27695-7910.
authors.forename: M
authors.initials: M
authors.lastname: Nazemi
authors.forename: C
authors.initials: C
authors.lastname: Kleinstreuer
authors.forename: J P
authors.initials: JP
authors.lastname: Archie
authors.forename: F Y
authors.initials: FY
authors.lastname: Sorrell
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D001018:Aortic Diseases / Q000209:etiology / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003251:Constriction, Pathologic / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D012039:Regional Blood Flow; D013314:Stress, Mechanical