Coumamidines, new broad spectrum antibiotics of the cinodine type. I. Discovery, taxonomy of the producing organism and fermentation.
Coumamidines are water-soluble basic antibiotics related to the glycocinnamoylspermidines. They are produced by a soil isolate designated Saccharopolyspora sp. AB 1167L-65. The coumamidines have broad spectrum activity and were selected in a screen for substances which inhibit Pseudomonas aeruginosa.
Jackson
M
M
Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois.
Karwowski
J P
JP
Theriault
R J
RJ
Kohl
W L
WL
Humphrey
P E
PE
Sunga
G N
GN
Swanson
S J
SJ
Villarreal
R M
RM
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000145:classification / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D003470:Culture Media; D005285:Fermentation; D008855:Microscopy, Electron, Scanning; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012988:Soil Microbiology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media