[Histopathology of meibomian gland abnormalities in experimental PenCB intoxicated beagle treated with squalane].
In order to examine the effect of squalane to excrete PCB from the intoxicated animals, histopathological studies of Meibomian gland abnormalities were carried out in experimental PenCB (3,4,5,3',4'-pentachlorobiphenyl) intoxicated beagles treated with squalane. All experimental animals except a control group showed characteristic changes of Meibomian glands: dilation of the duct and squamous metaplasia of the alveolar cells. According to the degree of these findings, five stages were divided in the processes of Medibomian gland changes. The PenCB intoxicated dogs initially showed mild pathological changes of the glands and later moderate to severe degrees of findings. In the PenCB intoxicated animals treated with squalane, severe degree of Meibomian gland findings were found in the early stage and mild to moderate abnormalities in the late stage. The concentration of PenCB in blood varied in each animal, and the animals with advanced Medibomian gland abnormalities tended to have high level of PenCB concentration in blood. In conclusion, the effect of squalane to excrete PCB from the intoxicated animals were not determined in this study.
Kohno
T
T
Ohnishi
Y
Y
D000818:Animals; D004285:Dogs; D005143:Eyelids / Q000473:pathology*; D008537:Meibomian Glands / Q000187:drug effects / Q000473:pathology*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000506:poisoning*; D013185:Squalene / Q000031:analogs & derivatives* / Q000627:therapeutic use
D013185:Squalene; D011078:Polychlorinated Biphenyls; C019556:squalane; C023035:3,4,5,3',4'-pentachlorobiphenyl