Impact of fat and glucose administration on metabolic and respiratory interactions in sepsis.
Metabolic and respiratory interactions were analyzed in a large group of septic patients (S) and in a reference group of nonseptics (NS) during the iv administration of glucose and fat. In spite of a moderate increase in CO2 production (VCO2) observed during the administration of fat in S, a VCO2-sparing effect of fat, with respect to equicaloric amounts of glucose, was reconfirmed. The relevance of the therapeutic modulation of CO2 production during parenteral nutrition, and the relative impact on the abnormal septic respiratory patterns, were emphasized by analyzing the physiological relationships and mechanisms responsible for the increase in respiratory work in sepsis.
Giovannini
I
I
Centro di Studio per la Fisiopatologia dello Shock, C.N.R., Catholic University School of Medicine, Rome, Italy.
Chiarla
C
C
Boldrini
G
G
Castagneto
M
M
D001424:Bacterial Infections / Q000503:physiopathology* / Q000628:therapy; D002245:Carbon Dioxide / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D014939:Work of Breathing
D004041:Dietary Fats; D002245:Carbon Dioxide; D005947:Glucose