In vivo degradation of noradrenaline by MAO A in locus coeruleus of the rat.
Depletion of noradrenaline in locus coeruleus neurons after reserpinization was prevented by clorgyline, a selective inhibitor of MAO A, but not by deprenyl, a selective inhibitor of MAO B. Only MAO A is therefore responsible for the degradation of homoneuronal noradrenaline in locus coeruleus nerve cells.
Blinc
M
M
Institute of Pathophysiology, Medical School, Ljubljana, Yugoslavia.
Dernovsek
M
M
Sket
D
D
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D006651:Histocytochemistry; D008125:Locus Coeruleus / Q000201:enzymology*; D008856:Microscopy, Fluorescence; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D012110:Reserpine; D008995:Monoamine Oxidase; D003010:Clorgyline; D009638:Norepinephrine