[Anomalies in the hemodynamic response to short lasting emotional stress in essential hypertensive subjects].
Systemic hemodynamics, brachial artery diameter (D) and blood flow velocity (v) were determined non-invasively in 26 normotensive subjects (NT) and 34 age- and sex-matched essential hypertensive patients (HT) using pulsed Doppler systems (4 and 8 MHz), at rest and during 2 min periods of mental arithmetic (MA) inducing reproducible changes in blood pressure. During MA in HT, v increased (from 5.3 +/- 1.1 to 8.4 +/- 1.6 cm/sec) to a greater extent (p less than 0.01) than in NT (from 4.9 +/- 0.7 to 6.3 +/- 1.4 cm/sec). Hand exclusion did not change the increase in v in HT and in NT. During MA, D did not change in both groups. Systolic and diastolic arterial pressure increased to a greater extent (p less than 0.01) in HT than in NT, while HR and pulse pressure increased to the same extent in both groups. Since cardiac output and D did not change during MA, instantaneous variations of v likely reflected modulation of arteriolar tone. These results suggest an enhanced vasodilatory response of muscle resistance vessels in HT as compared to NT. The lack of change in D suggest an increase in vascular tone of large arteries likely contributing to the rise in pulse pressure during MA in both groups.
Laurent
S
S
Centre de diagnostic, hôpital Broussais, Paris, France.
Lacolley
P
P
Brunel
P
P
Billaud
E
E
Laloux
B
B
Safar
M
M
D000328:Adult; D001827:Body Height; D001835:Body Weight; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D008954:Models, Biological; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
Anomalies de la résponse hémodynamique au stress émotionnel de courte durée chez l'hypertendu essentiel.