Immunological studies on thromboangiitis obliterans.
Using humoral immunity (gamma-globulin 18 cases, IgG, IgA, IgM each 30 cases, CH50, C3, C4 each 29 cases and CIC 31 cases), cellular immunity (E-RFC 68 cases, As 30 cases, SmIg, SmIgG each 18 cases, IMIT 30 cases) and immunopathological manifestations (light microscope, fluorescence microscope, transmitted electron microscope each 7 cases) as indices, we studied the immunological changes of "progressing", "remittent" and "stabilized" groups of patients with thromboangiitis obliterans (TAO) in different stages. Humoral immunity indicated that gamma-globulin, immune complex and IgG were all increased; cellular immunity indicated that the rate of T cells and suppressor cells was declined, while that of B cells was elevated. Immunopathologically, under light microscope all the layers of involved vessels were infiltrated with neutrophils, lymphocytes and monocytes; under fluorescence and electron microscope, immune complexes were found in the involved vessel walls. Our preliminary results suggest that TAO is an autoimmune disease relevant to antigen-antibody complex.
Zheng
P
P
Fu
P B
PB
Wang
W C
WC
Xu
W Y
WY
Tang
X M
XM
Ye
M
M
Chen
Z R
ZR
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D013919:Thromboangiitis Obliterans / Q000209:etiology / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D003165:Complement System Proteins