Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
Spontaneous rhythmic contractions were observed in some preparations of human isolated saphenous veins from old (greater than 60 years) subjects. These contractions were insensitive to adrenergic and histaminergic blockers, but were abolished by the cyclooxygenase inhibitors, aspirin and indomethacin, indicating the participation of endogenous eicosanoids.
Schoeffter
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Laboratoire de Pharmacodynamie Générale et de Pharmacologie, Université Catholique de Louvain, Bruxelles, Belgium.
Godfraind
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T
D000328:Adult; D000368:Aged; D000375:Aging; D001241:Aspirin / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D016861:Cyclooxygenase Inhibitors; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D024510:Muscle Development; D009130:Muscle, Smooth / Q000187:drug effects / Q000254:growth & development* / Q000503:physiopathology; D009543:Nifedipine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D012501:Saphenous Vein / Q000187:drug effects / Q000254:growth & development* / Q000503:physiopathology
D016861:Cyclooxygenase Inhibitors; D006632:Histamine; D011738:Pyrilamine; D009543:Nifedipine; D001241:Aspirin; D009638:Norepinephrine; D011224:Prazosin; D007213:Indomethacin; D010646:Phentolamine