Effect of maternal hormone treatment on lung protein leakage and lung function of preterm newborn rabbits.
We tested whether maternal administration of corticosteroids, thyrotropin-releasing hormone (TRH), triiodothyronine (T3) or their combinations, would improve lung function of ventilated preterm newborn rabbits. Maternal corticosteroids and T3 treatments did not improve lung compliance; TRH did. The major effect observed was a large improvement in lung compliance following maternal treatment with corticosteroids plus TRH in animals treated with surfactant. These agents made the lung "receptive" to the surfactant treatment. T3 did not improve lung function and no augmented response to surfactant was seen. None of the treated groups had surfactant pool sizes significantly different from controls. The mechanisms of action of corticosteroids and/or TRH seemed to be independent of changes in surfactant pool sizes.
Ikegami
M
M
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance.
Jobe
A
A
Pettenazzo
A
A
Seidner
S
S
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects*; D008170:Lung Compliance / Q000187:drug effects; D055370:Lung Injury; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000032:analysis / Q000494:pharmacology*; D011817:Rabbits; D012121:Respiration, Artificial / Q000009:adverse effects; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D011663:Pulmonary Surfactants; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone