Effect of beta-adrenergic blockade on lung liquid secretion during fetal asphyxia.
The hypothesis tested in this study was that beta-adrenergic stimulation is responsible for the inhibition of fetal lung liquid production during moderate fetal asphyxia. In chronically catheterized fetal sheep, net lung liquid production rates were measured over three consecutive periods: a control period, a period of reduced uterine blood flow (RUBF) or epinephrine infusion, and periods of RUBF or epinephrine infusion in the presence of the beta-adrenergic receptor antagonist propranolol. The net production rate of fetal lung liquid was decreased from a mean control value of 7.7 +/- 1.0 to 1.5 +/- 0.4 ml/h (P less than 0.001) by RUBF; the administration of propranolol had no further effect on these liquid production rates (1.1 +/- 0.5 ml/h). In other experiments epinephrine infusion reduced the net production rate of fetal lung liquid from a mean control value of 7.2 +/- 1.4 to 1.7 +/- 1.8 ml/h (P less than 0.025); the addition of propranolol reversed this inhibition (secretion rate 6.1 +/- 1.4 ml/h, P less than 0.005). We conclude that the inhibition of fetal lung liquid production induced by moderate fetal asphyxia does not solely result from catecholamine stimulation of pulmonary beta-receptors.
Hooper
S B
SB
Department of Physiology, Monash University, Melbourne, Victoria, Australia.
Harding
R
R
D000818:Animals; D001237:Asphyxia / Q000196:embryology / Q000503:physiopathology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005333:Fetus / Q000502:physiology; D006340:Heart Rate, Fetal; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D010313:Partial Pressure; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology*; D012039:Regional Blood Flow; D012756:Sheep; D014599:Uterus / Q000098:blood supply
D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D011433:Propranolol; D010100:Oxygen; D004837:Epinephrine