[Treatment of anovulation in polycystic ovary syndrome with clomiphene citrate in 10-day cycles].
The efficacy of a new schedule for the use of Clomiphene citrate (50 mg daily, during the first ten days of the cycle) is reported, in relation to ovulation induction and fertility. We treated 41 patients with the syndrome of polycystic ovary, who were anovulant and desired fertility. Ovulation was successfully induced in 35 of them (85.4%). Pregnancy was achieved in 28 patients (68.3%). In 87.5% of those becoming pregnant, gestations was achieved with less than 6 months of treatment. Our results are equally good or better than those reported in the literature with conventional treatment. Pregnancies obtained were normal. No congenital malformations were observed. There were only two abortions, spontaneous. No patient presented ovarian hyperstimulation syndrome. This new schedule is recommended because it is effective and it may give less complications. Also, it is not necessary to increase progressively the dose of clomiphene citrate.
Porcile
A
A
Venegas
E
E
Gallardo
E
E
D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy
D002996:Clomiphene
Tratamiento de la anovulación en el síndrome de ovarios poliquísticos con citrato de clomifeno en períodos de 10 dias.