Oxygen delivery and performance in the isolated, perfused rat heart: comparison of perfusion with aqueous and perfluorocarbon-containing media.
Perfluoro-octylbromide-containing perfusate is capable of supporting the contractile activity of isolated hearts. Because of the high oxygen content of such perfusate, "normal" mechanical function is maintained by such hearts with substantially reduced coronary flow.
Biro
G P
GP
Department of Physiology, University of Ottawa, Ontario, Canada.
Masika
M
M
Korecky
B
B
D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D002021:Buffers; D002245:Carbon Dioxide / Q000097:blood; D003326:Coronary Circulation / Q000187:drug effects; D005466:Fluorocarbons / Q000494:pharmacology*; D006321:Heart / Q000502:physiology*; D006842:Hydrocarbons, Brominated; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010313:Partial Pressure; D010477:Perfusion / Q000379:methods; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D001802:Blood Substitutes; D002021:Buffers; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D002245:Carbon Dioxide; C003072:perflubron; D010100:Oxygen