Effects of mepacrine on the oxidation of [1-14C]oleate in isolated rat hepatocytes.
In isolated rat hepatocytes, mepacrine stimulated the conversion of [1-14C]oleate into 14CO2 and depressed the formation of acid-soluble products from [1-14C]oleate. The action of mepacrine on [1-14C]oleate oxidation was not affected by exogenously applied phospholipase A2 (from Crotalus adamanteus venom) or arachidonic acid. It is suggested that mepacrine may exert its metabolic effects in isolated rat hepatocytes by a mechanism independent of phospholipase A2 inhibition.
Chihara
M
M
Department of Pharmacology, Fujita-Gakuen Health University School of Medicine, Aichi, Japan.
Nomura
T
T
Tachibana
M
M
Nomura
H
H
Nomura
Y
Y
Hagino
Y
Y
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D002118:Calcium / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009829:Oleic Acids / Q000378:metabolism*; D010084:Oxidation-Reduction; D011796:Quinacrine / Q000494:pharmacology*; D051381:Rats
D001095:Arachidonic Acids; D009829:Oleic Acids; D002245:Carbon Dioxide; D016718:Arachidonic Acid; D011796:Quinacrine; D002118:Calcium