Differential responses to growth factors by normal human mesothelial cultures from individual donors.
A significant interindividual variation in the growth rates is found in normal cultured human mesothelial (NHM) cells derived from different donors. This variation is observed when the mesothelial cells are incubated in medium containing serum and when the potencies of several separate growth factors are measured by using defined media. Depending on the donor, gamma-interferon and interleukin-2 can be toxic, have no effect, or stimulate the growth rate of NHM cells. Cultured NHM cells can be induced to multiply by growth factors that are released by activated macrophages. Thus, interindividual variation in NHM cell growth control could play a role in the pathogenesis of mesothelioma for a person exposed to asbestos.
Lechner
J F
JF
Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892.
LaVeck
M A
MA
Gerwin
B I
BI
Matis
E A
EA
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004815:Epidermal Growth Factor / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology
D006133:Growth Substances; D007376:Interleukin-2; D004815:Epidermal Growth Factor; D007371:Interferon-gamma; D004247:DNA