[Abnormalities of intestinal permeability of 51Cr-EDTA in mucoviscidosis].
Intestinal permeability to 51Cr-EDTA was studied in 20 children with cystic fibrosis (CF) and a mean age of 10.7 years, in 7 control adults and in 11 control children. 51Cr-EDTA urinary excretion (mean +/- SD) expressed as a percentage of the orally administered activity was: control children: 1.59 +/- 0.55%, control adults: 1.47 +/- 0.62%, CF patients: 10.7 +/- 8.6%. The difference between CF patients and control children on one hand, between CF patients and control adults on the other hand, was statistically significant (p less than 0.001). Only 3 CF patients had values within the limits of those observed in controls. A statistically significant correlation (p less than 0.01) was observed between the 51Cr-EDTA urinary excretion and steatorrhea. No correlation was found between 51Cr-EDTA urinary excretion and the following parameters: age, sex, weight, height, Shwachman score, liver cirrhosis, oral administration of a mucolytic agent. The eventual, especially nutritional, consequences of this increase of the intestinal permeability in the course of CF remain to be clarified.
Turck
D
D
Service de Pédiatrie et Génétique Médicale, Hôpital Huriez, CHU, Lille.
Boute
O
O
Ythier
H
H
Gottrand
F
F
Loeuille
G A
GA
Farriaux
J P
JP
D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000378:metabolism*; D004492:Edetic Acid / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D008297:Male
D004492:Edetic Acid
Anomalie de la perméabilité intestinale à l'EDTA-51Cr dans la mucoviscidose.