title: Influence of dietary protein, fat or amino acids on the response of weanling swine to aflatoxin B1.
abstract: Two experiments were conducted using corn from clean or aflatoxin B1 (AFB1)-contaminated (182 ppb) sources. Weanling pigs (28 d) were fed one of eight dietary treatments arranged in a 2 x 2 x 2 factorial design. In Exp. 1 (192 pigs), treatments varied in corn source (clean or AFB1-contaminated), CP level (18 or 20%) and added fat (0 or 5%). At the end of the 28-d growth trials, plasma samples were obtained. An AFB1 x CP level interaction was detected (P less than .05) for growth rate (ADG), feed intake (FI) and feed/gain ratio (F/G). Feeding AFB1 reduced (P less than .05) ADG (.30 vs .37 kg/d) and FI (.57 vs .66 kg/d) and increased F/G (1.88 vs 1.78) of pigs fed 18% CP diets. Performance of pigs fed 20% CP diets was not altered by AFB1. Adding 5% fat to diets improved (P less than .05) F/G but did not improve ADG of pigs fed AFB1. There was an AFB1 x CP x fat interaction (P less than .05) for plasma cholesterol. Adding fat or increasing the CP level prevented the depression of plasma cholesterol in pigs fed AFB1. In Exp. 2 (96 pigs), all diets contained 18% CP and the treatments varied in corn source (clean or AFB1-contaminated), added L-lysine HCl (0 or .25%) and added DL-methionine (0 or .15%). Feeding AFB1 reduced (P less than .05) ADG of pigs fed the 18% CP diet (.44 vs .50 kg/d) but not of pigs fed diets supplemented with .25% lysine.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: North Carolina State University, Raleigh 27695-7621.
authors.forename: M T
authors.initials: MT
authors.lastname: Coffey
authors.forename: W M
authors.initials: WM
authors.lastname: Hagler
authors.forename: J M
authors.initials: JM
authors.lastname: Cullen
mesh_terms: D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology*; D000821:Animal Feed; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D005506:Food Contamination; D013552:Swine / Q000502:physiology*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000348:Aflatoxins; D000596:Amino Acids; D004041:Dietary Fats; D004044:Dietary Proteins; D016604:Aflatoxin B1