title: Genotoxicity of particulate emissions from gasoline-powered engines evaluated by short-term bioassays.
abstract: Atmospheric pollutants, especially airborne particulates, contain a large number of genotoxic substances capable of inducing human health effects via inhalation. One important source of air pollutants are exhaust particles from automobile traffic. This concerns mainly diesel exhaust for which genotoxic properties are evident. With respect to particle emissions produced by gasoline-powered cars little information on a genotoxic potential is available. In this study 3 particulate emission extracts from different gasoline-powered cars driven with leaded or unleaded gasoline were investigated for cytotoxic and genotoxic activities by means of short-term bioassays using mammalian cell culture systems. All tested extracts were found to induce a broad spectrum of cytotoxic and genotoxic effects suggesting that gasoline exhausts are under high suspicion of contributing to health effects in human populations via air pollution.
authors.affiliation: Medizinisches Institut für Umwelthygiene, Universität Düsseldorf, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Hadnagy
authors.forename: N H
authors.initials: NH
authors.lastname: Seemayer
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001681:Biological Assay; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000187:drug effects; D005742:Gasoline / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008722:Methods; D010578:Petroleum / Q000009:adverse effects*; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D005742:Gasoline; D010578:Petroleum; D001335:Vehicle Emissions; D004247:DNA