Chromosome analysis of spontaneous abortions after IVF. A European survey.
A European survey was carried out in order to evaluate the incidence of chromosome anomalies in spontaneous abortions after IVF. Of the 34 abortuses analysed, 21 had a chromosome anomaly (62%), namely three with monosomy X,14 autosomal trisomies, one double trisomy, one triploidy, one tetraploidy and one translocation. These data show that IVF does not increase the incidence of chromosomal abortuses when compared with natural conceptions (60%).
Plachot
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Unité 173 INSERM, Hôpital Necker-Enfants-Malades, Paris, France.
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use; D005060:Europe; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D008423:Maternal Age; D008596:Menotropins / Q000009:adverse effects / Q000627:therapeutic use; D009006:Monosomy; D011123:Polyploidy; D011247:Pregnancy; D013480:Superovulation; D014178:Translocation, Genetic; D014314:Trisomy
D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins