Effect of praziquantel on the migration and survival of developmental stages of Schistosoma mansoni in mice.
Compressed organ autoradiography has been used to determine whether the anthelmintic drug praziquantel (Pzq) modifies the migration of isotopically labelled Schistosoma mansoni during the first 16 days of infection in CBA/Ca mice. The mice were treated with 500 mg kg-1 body weight of the drug on day 1 or day 6. Treatment caused a marked delay in parasite migration from the skin when the drug was administered intradermally at the site of infection on day 1; migration from the lungs was also delayed after such treatment. Pzq injected either intradermally on day 1 or intramuscularly on day 6 effectively reduced the number of parasites that finally arrived in the lungs and the livers by 41 and 47%, respectively. Intramuscular administration of the drug on day 1 had a negligible effect. Worm recoveries assessed on day 38 by perfusion of the hepatic portal system were greatly reduced when Pzq was administered on day 14. The worms proved less susceptible when the drug was administered on day 21 and were completely resistant following drug delivery on day 28. The influence of drug preparation and route of delivery on parasite migration and survival are discussed.
Flisser
A
A
Elsaghier
A A
AA
McLaren
D J
DJ
D000818:Animals; D001345:Autoradiography; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000502:physiology; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology*
D011223:Praziquantel