Influenza subtype-specific immunoglobulin A and G responses after booster versus one double-dose vaccination in hemodialysis patients.
The antibody response in hemodialysis patients was studied after one double dose of influenza vaccine versus one conventional dose plus a booster dose five weeks later. The influenza virus subtype specific IgA and IgG responses were recorded by means of an indirect immunofluorescence assay over a period of 20 weeks. Higher antibody titers, higher response rates and a higher rate of development of protective titers after the single double-dose vaccine indicated it was superior to the single dose/booster dose regimen. It is therefore suggested that hemodialysis patients are immunized with a higher dosage of influenza vaccine to achieve better protection rates.
Rautenberg
P
P
Abteilung für Medizinische Mikrobiologie, Christian-Albrechts-Universität, Kiel, FRG.
Proppe
D
D
Schütte
A
A
Ullmann
U
U
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology; D006435:Renal Dialysis; D013997:Time Factors
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007252:Influenza Vaccines