Thrombolysis with systemically administered t-PA in a new venous thrombosis model.
Early thrombosis of either the arterial or venous supply of a free flap or island pedicle flap results in total flap necrosis. Until very recently, the only option for flap salvage was surgical intervention and, often, revision of the vascular pedicle. Current advances in the pharmacologic treatment of coronary artery and deep leg vein thrombosis have kindled interest in the field of reconstructive surgery for pharmacologic treatment of thromboses that compromise flaps. In the past, there has been research on the local and systemic administration of thrombolytic agents for lysis of experimentally induced thrombi in various animal models. A new venous inversion graft thrombosis model is presented here, which possesses many advantages over previously employed research models. This study demonstrates thrombolysis with systemically administered tissue plasminogen activator (t-PA) in this model.
Hayden
R E
RE
Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
McLear
P W
PW
Phillips
J G
JG
Dawson
S M
SM
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005268:Femoral Vein / Q000601:surgery; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013524:Surgical Flaps; D013924:Thrombophlebitis / Q000188:drug therapy / Q000503:physiopathology*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014654:Vascular Patency
D010959:Tissue Plasminogen Activator