Evaluation of canine mast cell tumors for presence of estrogen receptors.
Ten tumors from 7 dogs were analyzed for estrogen receptors. Of 9 determined to be mast cell tumors, 6 were determined not to have estrogen receptors (less than 3 fmol of estradiol/mg of cytosol protein) and 3 were questionable (3 to 10 fmol of estradiol/mg). One tumor was a mixed mammary tumor and was determined to have estrogen receptors (12 fmol of estradiol/mg). Histologic grading of the mast cell tumors did not suggest a correlation with estrogen receptor values.
Larsen
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AE
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
Grier
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RL
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D004958:Estradiol / Q000378:metabolism; D005260:Female; D008297:Male; D012515:Mast-Cell Sarcoma / Q000032:analysis / Q000473:pathology / Q000662:veterinary*; D011960:Receptors, Estrogen / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary*
D011960:Receptors, Estrogen; D004958:Estradiol