The effect of diabetes on the molecular localization of maternal and fetal zinc and copper metalloprotein in the rat.
The molecular localization of maternal and fetal zinc and copper metalloproteins in diabetic and control rats was studied. Compared to controls, liver and kidneys of diabetic dams showed an increased concentration of zinc and copper that was associated with metallothionein. In contrast, fetuses of diabetic dams had lower zinc and metallothionein levels than fetuses from controls. The abnormal maternal trace element metabolism seen with diabetes resulted in alterations of zinc uptake and/or retention of their fetuses.
Uriu-Hare
J Y
JY
Department of Nutrition, University of California, Davis 95616.
Stern
J S
JS
Keen
C L
CL
D000818:Animals; D003300:Copper / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D008667:Metalloproteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism*
D008667:Metalloproteins; D003300:Copper; D015032:Zinc