Investigation of inositol hexakisphosphate actions in rat nucleus tractus solitarius in vitro.
Intracellular recordings from neurones in slices of rat brainstem containing the nucleus tractus solitarius were made to examine the effects of inositol hexakisphosphate (IP6) in a region where cardio-depressant effects had been reported in vivo in the same species. Bath application of IP6 failed to consistently alter the excitability, membrane potential or resistance even at concentrations up to 44 microM. Glutamate application (1-1.5 mM) was, however, effective in increasing excitability and depolarising these neurons. Thus, the neuronal mechanisms underlying the cardiovascular effects reported in vivo have not been resolved.
Brooks
P A
PA
Department of Physiology, Royal Free Hospital School of Medicine, University of London, U.K.
Spyer
K M
KM
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D010833:Phytic Acid