title: A single evening dose of rioprostil, 600 micrograms, in the treatment of acute duodenal ulcers.
abstract: When administered as 300 micrograms b.d. or as 600 micrograms once in the evening, the new prostaglandin E1 analogue, rioprostil, is capable of reducing nocturnal H+ activity (1200 h to 0800 h) by 52% and 74%, respectively (p less than 0.01). Diurnal acidity (0900 h to 1800 h), on the other hand, is only reduced by 33% and 15% (not significant). A single evening dose of rioprostil, 600 micrograms, is used successfully on 208 patients suffering from acute duodenal ulcer. After 2 weeks and 4 weeks of treatment, the healing rates are comparable to the high values obtained with ranitidine, 300 mg nocte (rioprostil, 600 micrograms nocte: 54.1% and 84.1%; ranitidine, 300 mg nocte: 54.4% and 89.9%). There are also no significant differences between the groups as regards symptomatic improvement. Severe diarrhoea and abdominal complaints do not occur with rioprostil, 600 micrograms nocte.
authors.affiliation: Krankenhaus Bethanien, Hamburg, West Germany.
authors.forename: H G
authors.initials: HG
authors.lastname: Dammann
authors.forename: M
authors.initials: M
authors.lastname: Dreyer
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Simon
authors.forename: P
authors.initials: P
authors.lastname: Demol
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000627:therapeutic use; D016630:Rioprostil
chemical_list: D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil; D011899:Ranitidine