Drug release rates from four sizes of a new transdermal nitroglycerin adhesive patch.
This study was conducted to determine the amount of nitroglycerin released from transdermal nitroglycerin patches of four different sizes: 3.3 cm2, 6.7 cm2, 13.3 cm2, and 20 cm2. Thirty healthy men received a single 24-hour application of each patch size according to a randomized, open-label, four-period crossover design. A 24-hour interval separated each treatment period. The total amount of nitroglycerin released by the four patches was proportional to size. All four patch sizes released nitroglycerin at a comparable rate. The mean overall 24-hour release rate of 0.76 mg/cm2 was similar to the release rate of 0.75 mg/cm2/24 hr observed in a previous study. Adverse experiences common to nitroglycerin administration were reported for all patch sizes, with headache, light-headedness, and nausea reported most frequently.
Riedel
D J
DJ
3M Riker, 3M Health Care Group, St. Paul, Minnesota.
Wick
K A
KA
Hawkinson
R W
RW
Kolars
C A
CA
Crowley
J K
JK
Harrison
L I
LI
de Dennis
S R
SR
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000009:adverse effects; D012867:Skin / Q000187:drug effects
D005996:Nitroglycerin