Effect of passive transfer of human anti-myelin-associated glycoprotein IgM in marmoset.
Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental animals. However, indirect immunofluorescence studies showed IgM deposition in close contact to myelin sheaths. Minor but distinct alterations of nerves were found in the adult: the enlargement of Schmidt-Lanterman incisures seen in electron microscopy could explain the decrease of the proportion of fibers of small diameter found by morphometry of semi-thin section, and the reduction of the mean internodal length in fibers of a given diameter seen in teased nerve fibers studies.
Dancea
S
S
Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpëtrière, Paris, France.
Dellagi
K
K
Renaud
F
F
Mahouy
G
G
Hauw
J J
JJ
Brouet
J C
JC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001327:Autoimmune Diseases / Q000209:etiology; D002143:Callitrichinae; D004594:Electrophysiology; D006801:Humans; D007116:Immunization, Passive; D007075:Immunoglobulin M / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D009185:Myelin Proteins / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D009420:Nervous System / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein