[GH-dependency of lymphocyte multiplication factor with a low molecular weight].
Liquid chromatography (FPLC) separation at pH 6.85 shows that the fractions in human serum which stimulate the multiplication of human lymphocyte are mainly in the 28-42 kd and the 1.3-1.9 kd fractions. The low molecular weight fraction is absent or very low in both GH-deficient and GH-resistant children and T lymphocyte-deficient children, and appears after appropriate treatment, i.e. GH or marrow transplantation. The data suggest the GH-dependency of 1.3-1.9 kd factor(s) produced by immuno-competent lymphocytes.
Schimpff
R M
RM
I.N.S.E.R.M. Hôpital Saint-Vincent-de-Paul, Paris.
Repellin
A M
AM
Bozzola
M
M
D002455:Cell Division / Q000187:drug effects; D013006:Growth Hormone / Q000032:analysis* / Q000172:deficiency; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D008661:Metabolism, Inborn Errors / Q000378:metabolism; D008970:Molecular Weight; D013601:T-Lymphocytes
D013006:Growth Hormone
GH-dépendance d'un facteur de multiplication lymphocytaire de petit poids moléculaire.