Pseudothrombocytopenia induced by a monoclonal IgM kappa platelet agglutinin.
Pseudothrombocytopenia is an in vitro phenomenon usually associated with anticoagulant (EDTA)-dependent IgG platelet agglutinins. A low Coulter platelet count was investigated in a 63-year-old woman with multiple sclerosis and a monoclonal IgM kappa gammopathy. An unusual type of EDTA- and temperature-independent IgM platelet agglutinin was identified by in vitro agglutination of donor platelets and was removed by immunoabsorption.
Hoyt
R H
RH
Department of Internal Medicine, University of Arizona Health Sciences Center, College of Medicine, Tucson 85724.
Durie
B G
BG
D000373:Agglutinins / Q000378:metabolism / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D004492:Edetic Acid / Q000502:physiology; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism / Q000502:physiology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications; D010265:Paraproteinemias / Q000097:blood / Q000150:complications*; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology*
D000373:Agglutinins; D007145:Immunoglobulin kappa-Chains; D004492:Edetic Acid