[Role of c-myc protein in the early embryonic development of Xenopus].
Microinjections of antibodies directed against the protein encoded by the c-myc protooncogene strongly inhibit or arrest the early cell cleavage stage of Xenopus laevis embryos. Injections in one blastomere of a two cell stage embryo inhibit the segmentation of this blastomere. The cleavage of the uninjected blastomere behaves normally. Injections of control rabbit immunoglobulins do not alter the embryonic development.
Méchali
M
M
Institut Jacques-Monod, Paris.
Evan
G
G
Gusse
M
M
D000818:Animals; D000906:Antibodies; D000941:Antigens / Q000276:immunology; D001757:Blastomeres / Q000166:cytology*; D002455:Cell Division; D007158:Immunologic Techniques; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc; D014982:Xenopus laevis / Q000196:embryology*
D000906:Antibodies; D000941:Antigens; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc
Rôle de la protéin c-myc dans le développement embryonnaire précoce chez le Xénope.