title: Initial experience with SPECT imaging of the brain using I-123 p-iodoamphetamine in focal epilepsy.
abstract: Nineteen patients with complex partial seizures refractory to medical treatment were examined with routine electroencephalography (EEG), video EEG monitoring, computed tomography or magnetic resonance imaging, neuropsychological tests and interictal single photon emission computed tomography (SPECT) with I-123 iodoamphetamine (INT). In 18 patients, SPECT identified areas of focal reduction in tracer uptake that correlated with the epileptogenic focus identified on the EEG. In addition, SPECT disclosed other areas of neurologic dysfunction as elicited on neuropsychological tests. Thus, IMP SPECT is a useful tool for localizing epileptogenic foci and their associated dynamic deficits.
authors.affiliation: Department of Radiologic Sciences, Medical College of Pennsylvania, Philadelphia.
authors.forename: M M
authors.initials: MM
authors.lastname: LaManna
authors.forename: N M
authors.initials: NM
authors.lastname: Sussman
authors.forename: R N
authors.initials: RN
authors.lastname: Harner
authors.forename: L R
authors.initials: LR
authors.lastname: Kaplan
authors.forename: B L
authors.initials: BL
authors.lastname: Hershey
authors.forename: D R
authors.initials: DR
authors.lastname: Bernstein
authors.forename: P
authors.initials: P
authors.lastname: Goldstein
authors.forename: J A
authors.initials: JA
authors.lastname: Parker
authors.forename: J G
authors.initials: JG
authors.lastname: Wolodzko
authors.forename: G L
authors.initials: GL
authors.lastname: Popky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; C041336:4-iodoamphetamine