[Study on the effect of disodium cromoglycate (DSCG) on antigen induced IL-2 responsiveness].
We tested the effects of disodium cromoglycate (DSCG) on antigen-induced IL-2 responsiveness in lymphocytes from patients with atopic dermatitis and/or bronchial asthma. Patient lymphocytes pretreated with 5 x 10(3) micrograms/ml DSCG for 24 or 48 hours failed to induce the responsiveness to IL-2 on stimulation with Dermatophagoides farinae (Df) or ovalbumin (OVA) antigen. DSCG-treated adherent cells were blocked to present the antigen to nonadherent responding cells for induction of IL-2 responsiveness. In contrast, DSCG-treated non-adherent cells, recombined with antigen-activated adherent cells, acquired IL-2 responsiveness. However, Con A-activated lymphocytes from the same patients were not affected by the same treatment. The results indicate that DSCG is capable of suppressing antigen-induced IL-2 responsiveness but not the response induced by mitogen such as Con A.
Ichikawa
K
K
Baba
M
M
Yoshizawa
I
I
Noma
T
T
D000941:Antigens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*
D000941:Antigens; D007376:Interleukin-2; D004205:Cromolyn Sodium