Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.
In 6 growth hormone-deficient children, we have demonstrated that 3-N-demethylation of caffeine as measured by the 13CO2 caffeine breath test is decreased following 1 month of growth hormone therapy (8.4 +/- 1.0 vs. 6.8 +/- 1.2% 13C/2 h after treatment). These findings could be of clinical importance. The initiation of growth hormone therapy in growth hormone-deficient children could alter the clearance of drugs metabolized through the mixed-function oxidase pathway given for concurrent conditions, and necessitate adjustment of the therapeutic regimen.
Levitsky
L L
LL
Department of Pediatrics, Michael Reese Medical Center, Ill.
Schoeller
D A
DA
Lambert
G H
GH
Edidin
D V
DV
D001944:Breath Tests; D002110:Caffeine / Q000378:metabolism*; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes; D002648:Child; D002675:Child, Preschool; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003640:Dealkylation; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism
D002247:Carbon Isotopes; D002245:Carbon Dioxide; D002110:Caffeine; D013006:Growth Hormone; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases