Methionine as methyl-group donor in the synthesis of Mycobacterium avium envelope lipids, and its inhibition by DL-ethionine, D-norleucine and DL-norleucine.
The radioactivity from 3H-methyl methionine was rapidly incorporated into the surface lipids of Mycobacterium avium. The transmethylation reaction was efficiently inhibited by DL-ethionine, D-norleucine and DL-norleucine. The structure of the outerlayer of the M. avium envelope was profoundly altered in the bacteria treated with DL-norleucine.
David
H L
HL
Unité de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France.
Clavel-Seres
S
S
Clément
F
F
Lazlo
A
A
Rastogi
N
N
D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D005001:Ethionine / Q000494:pharmacology; D008563:Membrane Lipids / Q000096:biosynthesis*; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D008854:Microscopy, Electron; D009162:Mycobacterium avium / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009646:Norleucine / Q000494:pharmacology
D008563:Membrane Lipids; D009646:Norleucine; D008715:Methionine; D005001:Ethionine