Deep inspiration increases the absorption of inhaled sodium cromoglycate.
The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A similar increase was found in three volunteers who undertook a single deep inspiration at 4 h. These data indicate that the absorption of cromoglycate from the airways can be affected by manoeuvres used to assess lung function.
Richards
R
R
Medicine 1, Southampton General Hospital.
Fowler
C
C
Simpson
S F
SF
Renwick
A G
AG
Holgate
S T
ST
D000042:Absorption; D000280:Administration, Inhalation; D000328:Adult; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005541:Forced Expiratory Volume; D006207:Half-Life; D006801:Humans; D008297:Male; D012119:Respiration
D004205:Cromolyn Sodium