Effect of toxic shock syndrome toxin-1 on human hemostatic parameters.
The effect of toxic-shock-syndrome-toxin-1 (TSST-1) on coagulation and platelet aggregation was studied in blood samples from human healthy volunteers. TSST-1 at 5 micrograms/ml does not modify the extrinsic or intrinsic coagulation pathways. However, thrombin clotting time (TCT) was significantly increased in the presence of TSST-1. Platelet aggregation was not directly affected by TSST-1 but the toxin strongly inhibited platelet aggregation induced either by epinephrine, adenosine diphosphate (ADP) or platelet activating factor (PAF), while having no effect on aggregation induced by thrombin, collagen or a calcium ionophore. The above results suggest that TSST-1 may bind to a transducer common for some aggregators or that it may induce some non-specific modification of platelet membrane.
Gareau
R
R
Département de chimie-biologie, Université du Québec à Trois-Rivières, Canada.
Gruda
J
J
Micusan
V V
VV
D000991:Antithrombins / Q000633:toxicity; D001427:Bacterial Toxins; D001780:Blood Coagulation Tests; D000001:Calcimycin / Q000037:antagonists & inhibitors; D003094:Collagen / Q000037:antagonists & inhibitors; D004768:Enterotoxins / Q000633:toxicity*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000633:toxicity; D013211:Staphylococcus aureus; D018089:Superantigens
D000991:Antithrombins; D001427:Bacterial Toxins; D004768:Enterotoxins; D010975:Platelet Aggregation Inhibitors; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D000001:Calcimycin; D003094:Collagen