title: Conformations of peptides containing Z-alpha,beta-dehydroleucine (delta ZLeu). A comparison of Boc-Pro-delta ZLeu-Gly-NHEt and Boc-Pro-delta ZPhe-Gly-NHEt.
abstract: Two tripeptides of the type Boc-Pro-delta ZX-Gly-NHEt (where X = Leu, Phe) have been synthesized and their solution conformations investigated by 270 MHz 1H n.m.r. and i.r. spectroscopy. These conformational studies indicated that delta ZLeu, similar to delta ZPhe, has a strong tendency to stabilize folded Type II beta-turn conformations when present at i + 2 position.
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
authors.forename: K
authors.initials: K
authors.lastname: Uma
authors.forename: P
authors.initials: P
authors.lastname: Balaram
authors.forename: P
authors.initials: P
authors.lastname: Kaur
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.forename: V S
authors.initials: VS
authors.lastname: Chauhan
mesh_terms: D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared
chemical_list: D009842:Oligopeptides; C068539:dehydroleucine; C068540:tert-butyloxycarbonyl-prolyl-dehydroleucyl-glycyl-ethylamide; C068541:tert-butyloxycarbonyl-prolyl-dehydrophenylalanyl-glycyl-ethylamide; D007930:Leucine