Induction of mixed function oxidase activities of protein A in rat mammary tumors.
Following s.c. administration of purified protein A, to 7,12-dimethylbenz(alpha)anthracene-induced mammary-tumor-bearing rats, a regenerated metabolism of the carcinogen was observed. The antitumor effect of protein A was evident from the decrease in tumor volume. The phase I and phase II enzyme activities suggest that protein A has the ability to induce the mixed function oxidases activity, which are active in the metabolism of xenobiotics.
Bansal
M R
MR
Department of Biophysics, Panjab University, Chandigarh, India.
Khanna
D
D
Gupta
K G
KG
Jain
P K
PK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004790:Enzyme Induction; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013205:Staphylococcal Protein A / Q000494:pharmacology*
D014408:Biomarkers, Tumor; D003573:Cytochrome b Group; D013205:Staphylococcal Protein A; D015127:9,10-Dimethyl-1,2-benzanthracene; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase; D000469:Alkaline Phosphatase; D005978:Glutathione