title: Lupus-like anticoagulants and lower extremity arterial occlusive disease.
abstract: Lupus-like anticoagulants (LLA), lupus anticoagulant and/or anticardiolipin antibody, are increasingly recognized in association with venous and arterial thrombotic events. We recently reviewed our experience with patients undergoing revascularization for lower-limb ischemia who were found to have LLA. Nine patients had LLA based on a prolongation of the partial thromboplastin time or by anticardiolipin assay by an enzyme-linked immunosorbent assay system. The ages of the patients ranged from 23 to 57 years. There were seven (78%) men, six (67%) blacks, two (22%) diabetic patients, and three (33%) hypertensive patients. One patient had systemic lupus erythematosus. All patients except one were cigarette smokers. Four patients had concurrent regulatory protein abnormalities: three protein C deficiencies, one protein S deficiency, and one plasminogen deficiency. The nine patients had 10 lower-extremity arterial reconstructions with two postoperative failures within 30 days. Patients were anticoagulated with heparin or aspirin after all but one operation. Patients at risk were identified on the basis of age (less than 51 years), unexplained early graft thrombosis, or history of venous or arterial thrombotic events. This group of patients is believed to be at risk for early postoperative thrombosis. Postoperative anticoagulation after revascularization for patients with LLA may be beneficial.
authors.affiliation: Department of Surgery, University of Illinois College of Medicine, Chicago.
authors.forename: J
authors.initials: J
authors.lastname: Eldrup-Jorgensen
authors.forename: L
authors.initials: L
authors.lastname: Brace
authors.forename: D P
authors.initials: DP
authors.lastname: Flanigan
authors.forename: T H
authors.initials: TH
authors.lastname: Schwarcz
authors.forename: G
authors.initials: G
authors.lastname: Fritsma
authors.forename: J P
authors.initials: JP
authors.lastname: Meyer
authors.forename: J J
authors.initials: JJ
authors.lastname: Schuler
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply*; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor