title: [The role of blood vessel endothelium in vascular smooth muscle reactivity to biologically active substances and drugs].
abstract: There are four humoral substances which are synthesized in the vascular endothelium: Endothelium Derived Relaxing Factor (EDRF); Endothelium Derived Hyperpolarizing Factor (EDHF); Endothelium Derived Contracting Factor (EDCF) and Prostacyclin. EDRF is identical with nitric oxide (NO), and, under physiological conditions is synthesized in the body from l-arginine. I the release of EDHF muscarinic M1 and M2 receptors are involved (implicated). EDCF (endothelin) is a 21 amino acid peptide (or series of peptides). The authors discuss the role and importance of the endothelum derived factors in different processes under physiological and pathophysiological conditions such as: regulation of the vascular tone, inflammation, trauma, hypertension, arteriosclerosis and aggregation.
authors.forename: V M
authors.initials: VM
authors.lastname: Varalić
authors.forename: M
authors.initials: M
authors.lastname: Prostran
authors.forename: M
authors.initials: M
authors.lastname: Jezdimirović
mesh_terms: D000818:Animals; D016232:Endothelins / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology
chemical_list: D016232:Endothelins; D009569:Nitric Oxide; D011464:Epoprostenol
vernacular_title: Znacaj endotela krvnih sudova za reaktivnost vaskularnog glatkog misića prema bioloski aktivnim supstancijama i likovima.