Plasma enteroglucagon, peptide YY and gastrin in rats deprived of luminal nutrition, and after urogastrone-EGF administration. A proliferative role for PYY in the intestinal epithelium?
Intestinal tissue mass was significantly reduced throughout the gastrointestinal tract (p less than 0.001) of intravenously fed (TPN) rats. Urogastrone-epidermal growth factor, (URO-EGF), reversed these changes. Although plasma enteroglucagon and gastrin levels showed a small increase with URO-EGF, this was far less than the gut tissue weight change, suggesting that it was unlikely that they were involved in modulating the proliferative response of the intestine to URO-EGF. Peptide tyrosine tyrosine (PYY) levels were however significantly increased by URO-EGF, indicating that PYY may possibly have a role in the modulation of intestinal cell proliferation.
Goodlad
R A
RA
Department of Histopathology, Royal Post-graduate Medical School, London, England.
Ghatei
M A
MA
Domin
J
J
Bloom
S R
SR
Gregory
H
H
Wright
N A
NA
D000818:Animals; D001835:Body Weight; D004064:Digestive System / Q000033:anatomy & histology; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005755:Gastrins / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D004763:Glucagon-Like Peptides / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010289:Parenteral Nutrition, Total; D019894:Peptide YY; D010455:Peptides / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D005768:Gastrointestinal Hormones; D010455:Peptides; D019894:Peptide YY; D004815:Epidermal Growth Factor; D004763:Glucagon-Like Peptides