title: Therapy for systemic juvenile rheumatoid arthritis with gamma-interferon: a pilot study of nine patients.
abstract: Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage.
authors.affiliation: Department of Pediatrics, University of Freiburg, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Pernice
authors.forename: L
authors.initials: L
authors.lastname: Schuchmann
authors.forename: J
authors.initials: J
authors.lastname: Dippell
authors.forename: J
authors.initials: J
authors.lastname: Suschke
authors.forename: P
authors.initials: P
authors.lastname: Vogel
authors.forename: H
authors.initials: H
authors.lastname: Truckenbrodt
authors.forename: F
authors.initials: F
authors.lastname: Schindera
authors.forename: C
authors.initials: C
authors.lastname: Humburg
authors.forename: J
authors.initials: J
authors.lastname: Brzoska
mesh_terms: D001171:Arthritis, Juvenile / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D010865:Pilot Projects; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma