[Evaluation of the intestinal absorption of iron orally administered as chondroitin sulfate in normal subjects].
The behaviour of sideremia has been studied in order to assess the intestinal absorption of iron of a new compound, ferric chondroitin sulfate after oral administration in 12 normal volunteers. After administration of 90 mg of iron as ferric chondroitin sulfate, sideremia rose from a basal value of 88 +/- 27 micrograms/dl to a value of 128 +/- 22 micrograms/dl at the third hour. Variance analysis showed that the increases were statistically significant (F = 27.7; p less than 0.00001). In the same subjects, the test was carried out in accordance with a randomised crossover design in two periods after administration of 91 mg of ferritin iron: sideremia rose from a basal value of 92 +/- 27 micrograms/dl to a value at the third hour of 97 +/- 28 micrograms/dl, moderate increases but statistically significant (F = 3.2; P = 0.0354). Variance analysis by repeated measurements showed that increases in sideremia were significantly higher after iron administration as ferric chondroitin sulfate than after administration of ferritin iron (F = 13.18; p = 0.0042). This study documents the good bioavailability of the iron contained in ferric chondroitin sulfate.
Bergamaschi
G
G
Università degli Studi di Pavia, Dipartimento di Medicina Interna e Terapia Medica.
Carlo-Stella
C
C
Pedrazzoli
P
P
Carozzi
A
A
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001682:Biological Availability; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D005290:Ferric Compounds / Q000097:blood*; D005293:Ferritins / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D012016:Reference Values; D013997:Time Factors
D005290:Ferric Compounds; D002807:Chondroitin; D002809:Chondroitin Sulfates; D005293:Ferritins
Valutazione dell'assorbimento intestinale di ferro somministrato per via orale come condroitinsolfato in soggetti normali.