[The erythrocyte phenotype Rh: 32,-46: transfusional and obstetric importance].
The red blood cells and sera from 21 RN/RN individuals were studied. The study confirmed the Rh type D+C+E-c-e+, CW-, characterized by an increased expression of the D antigen, a markedly decreased expression of the C and e antigens, the presence of a low incidence antigen (Rh32) and the absence of a high incidence antigen (Rh46) associated with an epitope recognized by a murine monoclonal antibody (MR 432). Four individuals exposed to Rh46 cells by pregnancy and/or transfusion had an anti-Rh46 antibody. This antibody gave positive reactions with all red blood cells of common and rare Rh phenotype except Rh null, D--, D.., DC(W-) and RN/RN cells. This antibody is considered to be of clinical significance in case of transfusion or pregnancy.
Le Pennec
P Y
PY
Centre National de Référence pour les Groupes Sanguins, Paris.
Rouger
P
P
Klein
M T
MT
Salmon
C
C
D000349:Africa / Q000208:ethnology; D001803:Blood Transfusion; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D011247:Pregnancy / Q000276:immunology*; D012203:Rh Isoimmunization / Q000208:ethnology / Q000235:genetics / Q000276:immunology; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D012204:Rh-Hr Blood-Group System
Le phénotype érythrocytaire Rh: 32,-46: importance transfusionnelle et obstétricale.