Breathing during wakefulness and sleep after human heart-lung transplantation.
To study the effects of pulmonary denervation on breathing during sleep, sleep studies were conducted on seven heart-lung transplant recipients (H-LT) and a comparable number of sex-matched normal subjects of similar age. Four of the H-LT patients had a restrictive pattern on spirometry. The time since transplantation ranged from 45 to 1,102 days. There were no significant differences between the groups with respect to total sleep time or distribution of sleep stages. There were no significant differences between the H-LT recipients and normal subjects with respect to baseline awake oxyhemoglobin saturation (SaO2) or the nadirs of SaO2 during REM and non-REM sleep, the absolute number and frequency (number per hour of sleep) of apneas, hypopneas, desaturation events, both over the whole night of study or separately during non-REM and REM sleep. Across wakefulness and all sleep stages, the H-LT patients tended to have shorter total respiratory cycle times (Ttot) (p = 0.052) and more rapid breathing frequency (F) than the normal subjects. This was associated with significantly shorter inspiratory times (Tl) (p less than 0.001) and smaller duty cycles (Tl/Ttot) (p less than 0.005) in the H-LT recipients. During non-REM and REM sleep, F tended to be higher in the H-LT recipients with pulmonary restriction than in the nonrestricted patients. There were no significant differences between the H-LT recipients and the normal subjects with regard to the periodicity of breathing, either in terms of timing parameters or breath amplitude.(ABSTRACT TRUNCATED AT 250 WORDS)
Sanders
M H
MH
Department of Medicine, University of Pittsburgh School of Medicine, PA 15261.
Costantino
J P
JP
Owens
G R
GR
Sciurba
F C
FC
Rogers
R M
RM
Reynolds
C F
CF
Paradis
I L
IL
Griffith
B P
BP
Hardesty
R L
RL
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D003714:Denervation; D005260:Female; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000294:innervation; D016040:Lung Transplantation; D008297:Male; D008991:Monitoring, Physiologic; D010108:Oxyhemoglobins / Q000378:metabolism; D012119:Respiration; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology; D014630:Vagus Nerve / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*
D010108:Oxyhemoglobins