GTP-binding proteins as possible targets for protein kinase C action.
The alpha-subunits of two guanine nucleotide binding proteins Gi and transducin, as well as the beta-subunit of transducin, serve as substrates for phosphorylation by the Ca2+- and phospholipid-dependent protein kinase C (PKC). Phosphorylation of the alpha-subunit of transducin is strictly dependent on its conformation and it is only the inactive form that is subjected to phosphorylation by PKC. This review will focus on the proposition that G proteins may serve as cellular targets for modulatory actions of PKC.
Sagi-Eisenberg
R
R
D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011493:Protein Kinase C; D019204:GTP-Binding Proteins