title: [Multicenter study of atenolol, combined with hydralazine and bendroflumethiazide in the treatment of essential, mild, and severe, arterial hypertension].
abstract: The aim of the present study was to determine both the effectiveness and tolerance of a preparation constituted by the combination at fixed doses of a betablocker (atenolol, 100 mg), a diuretic (bendroflumethiazide, 5 mg) and a vasodilator (hydralazine, 50 mg). The study was carried out on a sample formed by 46 patients with moderate or severe essential hypertension who received this preparation as a single antihypertensive therapy during 2 months. As for the hypotensive effectiveness of the product, obtained results demonstrate that arterial blood pressure (BP) levels were normalized in 89% of the patients with moderate essential hypertension and in 9/10 patients with severe hypertension. Tolerance was excellent in most of the cases. Although new studies should be performed in order to enlarge the number of available case-studies, the above presented data allow us to conclude with a positive opinion about the studied combination.
authors.forename: I J
authors.initials: IJ
authors.lastname: Ferreira
authors.forename: L
authors.initials: L
authors.lastname: Escosa
authors.forename: J A
authors.initials: JA
authors.lastname: Casasnovas
authors.forename: S J
authors.initials: SJ
authors.lastname: Barrios
authors.forename: J M
authors.initials: JM
authors.lastname: Marcos
authors.forename: H
authors.initials: H
authors.lastname: Pardell
authors.forename: A
authors.initials: A
authors.lastname: Navarro
authors.forename: V
authors.initials: V
authors.lastname: de la Fuente
mesh_terms: D000328:Adult; D000368:Aged; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use*; D001539:Bendroflumethiazide / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D006830:Hydralazine; D001262:Atenolol; D001539:Bendroflumethiazide
vernacular_title: Estudio multicéntrico del atenolol, asociado con hidralazina y bendroflumetiazida en el tratamiento de la hipertensión arterial esencial, moderada y severa.