title: Benign cephalic histiocytosis: report of four cases.
abstract: We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein-negative by immunoperoxidase (PAP method). One patient showed comma-shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self-limiting condition that requires no treatment.
authors.affiliation: Section of Pediatric Dermatology, Hospital Ramos Mejía, Ceni, Argentina.
authors.forename: M L
authors.initials: ML
authors.lastname: de Luna
authors.forename: I
authors.initials: I
authors.lastname: Glikin
authors.forename: J
authors.initials: J
authors.lastname: Golberg
authors.forename: S
authors.initials: S
authors.lastname: Stringa
authors.forename: R
authors.initials: R
authors.lastname: Schroh
authors.forename: J
authors.initials: J
authors.lastname: Casas
mesh_terms: D002610:Cheek; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis / Q000473:pathology; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis