title: Immunization of cattle with a Theileria parva bovis stock from Zimbabwe protects against challenge with virulent T.p. parva and T.p. lawrencei stocks from Kenya.
abstract: Following inoculation of 34 Bos indicus (Boran) cattle with a Theileria parva bovis (Boleni) stock from Zimbabwe, 18 animals underwent mild theilerial reactions, 12 underwent moderate reactions, three suffered severe reactions and one died. When these animals were subsequently challenged with different virulent stocks of either T.p. parva (Muguga, Marikebuni or Mariakani) or T.p. lawrencei (Ngong 1 or Nanyuki) from Kenya, all except two animals resisted challenge. The two reactors were part of the group challenged with the T.p. parva (Mariakani) stock. All 12 susceptible control animals underwent severe reactions and 11 died. The results of these experiments suggest that T.p. bovis (Boleni) may be used in some situations to immunize cattle against East Coast fever without the need to provide concomitant chemotherapy as in the infection and treatment method of immunization.
authors.affiliation: International Laboratory for Research on Animal Diseases (ILRAD), Nairobi, Kenya.
authors.forename: A D
authors.initials: AD
authors.lastname: Irvin
authors.forename: S P
authors.initials: SP
authors.lastname: Morzaria
authors.forename: F C
authors.initials: FC
authors.lastname: Munatswa
authors.forename: R A
authors.initials: RA
authors.lastname: Norval
mesh_terms: D000818:Animals; D016782:Apicomplexa / Q000276:immunology* / Q000472:pathogenicity; D002417:Cattle; D007114:Immunization / Q000662:veterinary*; D007630:Kenya; D013801:Theileriasis / Q000517:prevention & control*; D014774:Virulence; D015030:Zimbabwe