Preoperative intra-arterial infusion chemotherapy for patients with bladder cancer.
The effectiveness of the preoperative intra-arterial infusion chemotherapy was studied in 27 patients with muscular invasive bladder cancer. Severe histological destruction of tumor structures was found in 7 cases in the removed bladder at surgery. For these cases, 3-year and 5-year survival rates were 100%. On the other hand, for cases whose destruction of tumor structures was of mild degree or less, 3-year survival rates were 51.9-57.1%. No serious side effect was observed. This preoperative therapy was thought to offer advantages for some patients with muscular invasive bladder cancer.
Kubota
Y
Y
Department of Urology, Yamagata University School of Medicine, Japan.
Kakizaki
H
H
Numasawa
K
K
Suzuki
K
K
Kato
H
H
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D011300:Preoperative Care; D001743:Urinary Bladder / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery
D000970:Antineoplastic Agents; D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil