Methysergide-induced psychosis: case report with long-term follow-up.
Methysergide, a congener of LSD and potent serotonin (5-HT) antagonist, induced a florid transient psychosis resembling an LSD psychosis in a patient with spasmodic torticollis with a family history of schizophrenia. Thirteen years later he developed a major depression. A variety of other drug challenges and treatments for his torticollis had no psychotomimetic effect. Blockade of 5-HT receptors may subserve methysergide-induced psychosis.
Skorzewska
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Department of Psychiatry, Montreal General Hospital P.Q., Canada.
Lal
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D000328:Adult; D003702:Delusions / Q000139:chemically induced; D003866:Depressive Disorder / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D008297:Male; D008784:Methysergide / Q000008:administration & dosage / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D014103:Torticollis / Q000188:drug therapy*
D008784:Methysergide