The gene structure of the insulin-like growth factor family.
The insulin-like growth factors (IGF) constitute a family of proteins with insulin-like and growth-stimulating properties. The best characterized members of this family are IGF-I, a protein of 70 amino acids which plays an important role in post-natal growth, and IGF-II, a 67 amino acid protein which is most likely involved in fetal development. The gene structure of IGF-II has been elucidated for the human and the rat and shows extensive interspecies homologies. The gene structure of IGF-I has only partially been established. A striking feature of the IGF genes is that they are controlled by multiple promoters which are expressed in a tissue-specific and development-dependent way.
Sussenbach
J S
JS
Laboratory for Physiological Chemistry, State University of Utrecht, The Netherlands.
D000818:Animals; D001483:Base Sequence; D004247:DNA; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013002:Somatomedins / Q000235:genetics*
D013002:Somatomedins; D004247:DNA