Does midtrimester delta OD450 of amniotic fluid reflect severity of Rh disease?
Thirty-two patients with Rh-immunized pregnancies had amniocenteses between 16 and 20 weeks' gestation. Serial amniotic fluid values of delta optical density at 450 nm were studied to predict the severity of Rh disease. A value greater than 0.15 indicated severe Rh immunization. Values less than 0.09 indicated mild or no Rh disease; delta optical density at 450 nm between 0.09 and 0.15 require further evaluation to determine the trend. Midtrimester amniocentesis is a simple technique that helps to determine which patients may or may not require fetal blood sampling.
Ananth
U
U
Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, D.C. 20007.
Queenan
J T
JT
D000653:Amniotic Fluid / Q000502:physiology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012203:Rh Isoimmunization / Q000503:physiopathology*; D012720:Severity of Illness Index