title: Interhemispheric desynchronization of spontaneous spike-wave discharges by corpus callosum transection in rats with petit mal-like epilepsy.
abstract: Wistar rats of a strain inbred for spontaneous generalized non-convulsive seizures present EEG spike-wave discharges (SWDs), 7-10 c/sec, occurring about once/min and lasting about 15 sec. They are bilateral and synchronous and can be recorded over the entire neocortex and in the lateral thalamic nuclei. After corpus callosum section, only a few bilateral SWDs persisted. Asymmetrical SWDs were most often recorded: bilateral SWDs starting asynchronously, or unilateral SWDs, which were also seen to alternate abruptly between hemispheres. The thalamic SWDs were always synchronized with the ipsilateral cortical pattern. These findings suggest that while the corpus callosum has a major role in bilateral synchronization of SWD in this model of epilepsy, occasional synchronization may still occur through other pathways after callosal transection.
authors.affiliation: Département de Neurophysiologie et Biologie des Comportements, Centre de Neurochimie du CNRS/U. 44 INSERM, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Vergnes
authors.forename: C
authors.initials: C
authors.lastname: Marescaux
authors.forename: B
authors.initials: B
authors.lastname: Lannes
authors.forename: A
authors.initials: A
authors.lastname: Depaulis
authors.forename: G
authors.initials: G
authors.lastname: Micheletti
authors.forename: J M
authors.initials: JM
authors.lastname: Warter
mesh_terms: D000818:Animals; D003337:Corpus Callosum / Q000503:physiopathology*; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains