An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes.
An interleukin-3-dependent progenitor clone LyD9 and its interleukin-4-dependent derivative clone K-4 were shown to differentiate into myeloid cells as well as B lymphocytes by coculture with bone marrow stroma cells. The K-4 clone is an intermediate between myeloid/lymphoid cells and the LyD9 clone that requires interleukin-4 for differentiation into B lymphocytes and myeloid cells. Granulocyte-macrophage colony stimulating factor-dependent derivatives (LS-1 and K-GM) were also established from induced LyD9 cells. LS-1 and K-GM were myeloid-committed cells.
Kinashi
T
T
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Tashiro
K
K
Inaba
K
K
Takeda
T
T
Palacios
R
R
Honjo
T
T
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D002999:Clone Cells / Q000166:cytology / Q000276:immunology; D006098:Granulocytes / Q000166:cytology / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D007377:Interleukin-3 / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology*; D008264:Macrophages / Q000166:cytology / Q000276:immunology
D007377:Interleukin-3; D015847:Interleukin-4