title: Heparin inhibits the "quasi-lipoxygenase" activity of hemoglobin toward linoleic acid by oxidant scavenging.
abstract: Previous studies have shown heparin to have antiinflammatory properties. We have attempted to determine if the mechanism involves the inhibition of lipid oxidation by utilizing a model system where linoleic acid is oxidized in the presence of oxygen and methemoglobin. Heparin inhibits this "quasi-lipoxygenase" activity prolonging the lag phase and slowing the rate of lipid peroxidation. An oxidant scavenging mechanism is also inferred from the fact that heparin is capable of inhibiting luminol-dependent chemiluminescence resulting from the reduction of 15-HPETE by methemoglobin. It is concluded that heparin, in at least this model system, is capable of inhibiting lipoxygenation by an oxidant scavenging mechanism.
authors.affiliation: Department of Medicine, University School of Medicine, Morgantown, WV 26506.
authors.forename: E P
authors.initials: EP
authors.lastname: Brestel
authors.forename: M T
authors.initials: MT
authors.lastname: Koes
mesh_terms: D006493:Heparin / Q000494:pharmacology*; D015289:Leukotrienes / Q000378:metabolism; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D008163:Luminescent Measurements; D008353:Mannitol / Q000494:pharmacology; D008706:Methemoglobin / Q000378:metabolism*; D008956:Models, Chemical; D010084:Oxidation-Reduction / Q000187:drug effects
chemical_list: D015289:Leukotrienes; D008041:Linoleic Acids; D008054:Lipid Peroxides; D016859:Lipoxygenase Inhibitors; D008353:Mannitol; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D006493:Heparin; D008706:Methemoglobin; D019787:Linoleic Acid