Myelodysplastic syndrome: prospective evaluation of fifty-one patients using the Dutcher scoring system.
Fifty-one patients with primary myelodysplastic syndrome were prospectively evaluated using a scoring system based on the presentation blood and bone marrow findings. Twenty-four patients (47%) evolved to acute nonlymphocytic leukemia. Stepwise regression model showed that the scoring system was the only significant variable for predicting transformation to acute leukemia (p = 0.0007, sensitivity 70.8%, specificity 77.8%). Seventy-six percent of patients with a score of 14 or greater developed acute leukemia compared to 19% with a score of 13 or less. Median survival of the entire group was 10 months. The most important prognostic factor for predicting survival was the scoring system (p = 0.0001). Survival correlated inversely with the score. This scoring system may be useful in the management of patients with myelodysplasia.
Doll
D C
DC
Department of Medicine, Harry S. Truman Memorial Veterans Hospital, Columbia, Mo.
Taylor
H M
HM
Yesus
Y W
YW
Caldwell
C W
CW
Anderson
S
S
Madsen
R
R
Ringenberg
Q S
QS
Yarbro
J W
JW
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000097:blood / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000401:mortality / Q000473:pathology*; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies