Changes in cranial CSF volume during hypercapnia and hypocapnia.
Magnetic resonance imaging was used to measure the effect of inhalation of 7% CO2 and hyperventilation with 60% O2 on human cranial cerebrospinal fluid volume. During CO2 inhalation there was a reduction in the cranial CSF volume ranging from 0.7-23.7 ml (mean 9.36 ml). The degree of reduction in cranial CSF volume was independent of the individual subject's increase in end-expiratory pCO2 or mean arterial blood pressure, in response to hypercapnia. During hyperventilation with high concentration oxygen the cranial CSF volume increased in all subjects (range 0.7-26.7 ml, mean 12.7 ml). The mean changes in cranial CSF volume, induced by hypercapnia and hypocapnia, were very similar to the expected reciprocal changes in cerebral blood volume.
Grant
R
R
University Department of Neurosurgery, Glasgow, Scotland, UK.
Condon
B
B
Patterson
J
J
Wyper
D J
DJ
Hadley
M D
MD
Teasdale
G M
GM
D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D007427:Intracranial Pressure; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D014661:Vasoconstriction; D014664:Vasodilation
D002245:Carbon Dioxide; D010100:Oxygen