Rate of reproductive involution following either exposure to short days or daily administration of melatonin is faster in inbred than in random-bred female Syrian hamsters.
The onset of cessation of oestrous cyclicity and associated organ and hormonal changes were compared in random-bred (RB) and inbred (IB) female Syrian hamsters kept either under short days (8 h light:16 h darkness; 8L:16D) or long days (14L:10D) and given daily afternoon injections of 25 micrograms melatonin. In response to short-day treatment, 100% of the IB hamsters exhibited vaginal acyclicity within 35 days; by comparison, none of the RB animals were acyclic at this time. The IB hamsters also exhibited other changes associated with exposure to short days, including increased body weight, enlarged ovaries, regressed uteri, elevated pituitary concentrations of FSH, and depressed pituitary and plasma concentrations of prolactin. At this time, only the pituitary FSH levels were increased in the RB animals kept under the same short-day conditions. In a second experiment, RB and IB female Syrian hamsters were maintained under long days (14L:10D) and the rate of reproductive regression in response to daily afternoon injections of melatonin was compared. After 8 weeks of melatonin injections, 80% of the IB females were anoestrous, while all RB hamsters were still exhibiting 4-day oestrous cycles. Other changes associated with melatonin administration in the IB females included a marked drop in uterine weight and a depression in pituitary and plasma prolactin levels. The RB hamsters, although they were all still cyclic after 8 weeks, had increased body and ovarian weights, increased pituitary concentrations of FSH, and lower pituitary and plasma prolactin levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Reiter
R J
RJ
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
Sabry
I
I
Nordio
M
M
Vaughan
M K
MK
Migliaccio
S
S
D000818:Animals; D001835:Body Weight; D001947:Breeding; D006224:Cricetinae; D004971:Estrus / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D008027:Light; D008550:Melatonin / Q000494:pharmacology*; D008647:Mesocricetus; D010053:Ovary; D011388:Prolactin / Q000032:analysis; D051381:Rats; D013997:Time Factors
D011388:Prolactin; D005640:Follicle Stimulating Hormone; D008550:Melatonin