Hyperprolactinemia, galactorrhea and amenorrhea in women with a spinal cord injury.
Six women with a traumatic spinal cord injury (SCI) developed hyperprolactinemia, amenorrhea and galactorrhea. Five of them had thoracic level lesions and 1 had a lumbosacral lesion. Two were postpartum and 1 was pregnant at the time of injury. Transient diabetes insipidus developed in 1 patient. Temporary administration of bromocriptine decreased prolactin levels, caused cessation of lactation and restored ovulatory cycles. The syndrome disappeared spontaneously in all 6 patients. Pituitary stalk concussion resulting from the trauma might cause this phenomenon, with the level of the cord injury playing a role. Being pregnant or early postpartum can predispose women to develop this syndrome.
Berezin
M
M
Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Ohry
A
A
Shemesh
Y
Y
Zeilig
G
G
Brooks
M E
ME
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000209:etiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000097:blood / Q000209:etiology*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006966:Hyperprolactinemia / Q000097:blood / Q000209:etiology*; D007775:Lactation Disorders / Q000209:etiology*; D007986:Luteinizing Hormone / Q000097:blood; D013119:Spinal Cord Injuries / Q000097:blood / Q000150:complications*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine; D006854:Hydrocortisone