title: Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction.
abstract: By using polymerase chain reaction and differential hybridization, point mutations of N-ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N-ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Mano
authors.forename: F
authors.initials: F
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D011905:Genes, ras; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*
chemical_list: D015342:DNA Probes; D004273:DNA, Neoplasm