Marrow transplantation for children with acute leukemia: experience of Pesaro.
Thirty children aged 1-15 years with acute lymphoblastic leukemia and acute nonlymphoblastic leukemia were transplanted from HLA-matched donors using two different preparative regimens: 18 patients were prepared with cyclophosphamide and total body irradiation (TBI) while 12 patients received busulphan and cyclophosphamide. Fifteen patients survived 7 to 74 months after transplant. The association of busulphan and cyclophosphamide is a well-tolerated preparation for bone marrow transplant in children with eradicating and immunosuppressive efficacy comparable to that of the well-experienced TBI-cyclophosphamide association.
Giardini
C
C
Divisione Ematologica, Muraglia Ospedale, Pesaro, Italia.
Polchi
P
P
Lucarelli
G
G
Galimberti
M
M
Angelucci
E
E
Baronciani
D
D
Durazzi
S M
SM
Manenti
F
F
Politi
P
P
Moretti
L
L
D000206:Actuarial Analysis; D000293:Adolescent; D001772:Blood Cell Count; D001853:Bone Marrow / Q000032:analysis; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011300:Preoperative Care; D011379:Prognosis; D012008:Recurrence
D005819:Genetic Markers