Developmental changes in galactosyltransferase activity in the rat small intestine.
During postnatal development, UDP-Gal: GlcNAc(beta 1-4)-galactosyltransferase (4 beta-GT) and UDP-Gal:GalNAc(beta 1-3)-galactosyltransferase (3 beta-GT) activities were increased by 17- and 24-fold, respectively, in the rat small intestine. The injection of cortisone into suckling rats resulted in precocious induction of distal 4 beta- and 3 beta-GT activities by 2.7- and 1.8-fold, respectively. Injection of phorbol-12-myristate-13-acetate (PMA) resulted in precocious induction of distal 3 beta-GT by 2.7-fold. These results suggest that intestinal galactosyltransferase activities are under developmental regulation and can be modified by cortisone and PMA.
Ozaki
C K
CK
Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, MA 02115.
Chu
S H
SH
Walker
W A
WA
D000375:Aging; D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D007700:Kinetics; D007788:Lactose Synthase / Q000378:metabolism*; D009237:N-Acetyllactosamine Synthase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007788:Lactose Synthase; D009237:N-Acetyllactosamine Synthase; D013755:Tetradecanoylphorbol Acetate; D003348:Cortisone