Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie.
Viremia is found in intraperitoneally scrapie-injected hamsters. The absence of a viremic peak before the beginning of scrapie replication in the brain suggests either that the spread of the agent to the brain is not via the blood or that early after infection, circulating monocytes carry the agent to the brain where it remains silent until the neural cells start replicating it.
Casaccia
P
P
Istituto di Patologia Generale, Università Cattolica S. Cuore, Rome, Italy.
Ladogana
A
A
Xi
Y G
YG
Pocchiari
M
M
D000818:Animals; D001921:Brain / Q000382:microbiology; D006224:Cricetinae; D011328:Prions / Q000254:growth & development / Q000472:pathogenicity*; D012608:Scrapie / Q000382:microbiology*; D013154:Spleen / Q000382:microbiology; D014766:Viremia / Q000382:microbiology*
D011328:Prions