Synthesis and non-thrombogenicity of polyurethanes with poly(oxyethylene) side chains in soft segment regions.
Epoxidized polybutadiene-urethanes were synthesized and grafted with poly(oxyethylene)s. The non-thrombogenicity of the graft polyurethanes was investigated in relation to the content of poly(oxyethylene). The grafting of poly(oxyethylene) to polyurethane suppressed adsorption and denaturation of plasma proteins and platelet adhesion. It was also found that there exists an optimum content of poly(oxyethylene) for the graft polyurethane to attain the highest non-thrombogenicity.
Liu
S Q
SQ
Department of Polymer Chemistry, Faculty of Engineering, Kyoto University, Japan.
Ito
Y
Y
Imanishi
Y
Y
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry; D004285:Dogs; D008956:Models, Chemical; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013816:Thermodynamics; D013927:Thrombosis / Q000139:chemically induced
D001672:Biocompatible Materials; D001798:Blood Proteins; D011140:Polyurethanes; D011092:Polyethylene Glycols