title: [Endobronchial administration of netilmicin in patients with bronchopulmonary infections seen in the neurosurgical intensive care unit].
abstract: The Authors report the results obtained in the treatment of bronchopulmonary infections in patients hospitalized in the Neurosurgical Intensive Care Unit. Netilmicin was administered by systemic and endobronchial routes. The cleaning of the bronchial tree was always performed. Twenty-six patients (16 males and 10 females) were enrolled and assigned to one of the following groups. Group A: 16 patients with confirmed pneumonia; Group B: 10 patients without bronchopulmonary infections, as controls for serum pharmacokinetic study. In the majority of the cases pneumonia was caused by Staphylococcus aureus and Pseudomonas aeruginosa. The results obtained were positive: pneumonia resolution was observed in 10 patients (67%), improvement in 4 (27%) and failure in one case (6%). A pharmacokinetic study has confirmed bacteriologically active serum levels of netilmicin and also the availability of netilmicin within the bronchial secretions. Endobronchial plus systemic netilmicin administration was active and well tolerated in these critical patients.
authors.forename: L
authors.initials: L
authors.lastname: Spiga
authors.forename: M
authors.initials: M
authors.lastname: Patelli
authors.forename: L
authors.initials: L
authors.lastname: Pacifico
authors.forename: M
authors.initials: M
authors.lastname: Simonetti
authors.forename: V
authors.initials: V
authors.lastname: Poletti
authors.forename: S
authors.initials: S
authors.lastname: Roccuzzo
authors.forename: G
authors.initials: G
authors.lastname: Orlandi
authors.forename: L
authors.initials: L
authors.lastname: Franchino
mesh_terms: D001980:Bronchi; D001996:Bronchopneumonia / Q000188:drug therapy*; D003428:Cross Infection / Q000188:drug therapy*; D004333:Drug Administration Routes; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007362:Intensive Care Units; D008297:Male; D009428:Netilmicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009493:Neurosurgery; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D009428:Netilmicin
vernacular_title: Somministrazione endobronchiale di netilmicina in pazienti con infezioni broncopolmonari ricoverati in unità di terapia intensiva neurochirurgica.