Use of fibronectin and somatomedin-C as nutritional markers in the enteral nutrition support of traumatized patients.
Enteral nutrition support was provided to 12 critically ill, traumatized patients by continuous NG infusion with a nutritionally complete formula for at least 7 consecutive days. Serum for fibronectin (Fn) and somatomedin-C (Sm-C) was collected and nitrogen balance (NB) was measured on days 1, 4, 7, 14, 21, and 28 of the study period. Estimated energy and protein requirements were based, respectively, on the patient's calculated basal energy expenditure multiplied by a stress factor and urea nitrogen excretion (plus 4) during 24-h urine collections. Enteral feedings were started 5.3 +/- 3.8 days after injury; patients received an average of 33.2 +/- 3.9 kcal/kg.day and 1.5 +/- 0.4 g protein/kg.day. Fn concentrations increased significantly (p less than .05) from baseline on study days 7, 14, 21, and 28, whereas NB increased significantly (p less than .05) on study days 4, 7, 14, 21, and 28. Significant correlations were found between Fn and NB (r = .52, p less than .005), Fn and cumulative caloric intake (r = .54, p less than .005), and Fn and cumulative nitrogen intake (r = .62, p less than .005). There were no significant changes observed with Sm-C concentrations during the study period. Measurement of Fn concentrations appears to have potential as a nutrition support marker in traumatized patients, particularly in monitoring short courses of nutrition support. The role of Sm-C as a nutrition marker requires further investigation.
Buonpane
E A
EA
Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.
Brown
R O
RO
Boucher
B A
BA
Fabian
T C
TC
Luther
R W
RW
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003422:Critical Care; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009752:Nutritional Status; D011446:Prospective Studies; D013002:Somatomedins / Q000097:blood*; D014193:Trauma Centers; D014947:Wounds and Injuries / Q000628:therapy*
D015415:Biomarkers; D005353:Fibronectins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D009584:Nitrogen