title: Intravenous administration of d-tubocurarine and pancuronium in fetal limbs.
abstract: The purpose of this study was to assess the effects of intravenous administration of d-tubocurarine and pancuronium in fetal lambs. Eighteen experiments were performed in seven chronically instrumented pregnant ewes between 0.8 and 0.9 of timed gestation. Each fetus received 6 ml of study drug intravenously at 1.2 ml/min over 5 minutes (d-tubocurarine 3.0 mg/kg, pancuronium 0.5 mg/kg, or saline solution control). Pancuronium (n = 7) significantly increased both fetal heart rate and mean arterial pressure. d-Tubocurarine (n = 5) significantly decreased both fetal heart rate and mean arterial pressure. Saline solution control (n = 6) did not significantly alter fetal heart rate or mean arterial pressure. The present study suggests that pancuronium is preferable to d-tubocurarine for those intrauterine procedures when an increase in fetal heart rate is desired.
authors.affiliation: Department of Anesthesia, University of Iowa College of Medicine, Iowa City.
authors.forename: D H
authors.initials: DH
authors.lastname: Chestnut
authors.forename: C P
authors.initials: CP
authors.lastname: Weiner
authors.forename: C S
authors.initials: CS
authors.lastname: Thompson
authors.forename: G L
authors.initials: GL
authors.lastname: McLaughlin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D006340:Heart Rate, Fetal / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010197:Pancuronium / Q000494:pharmacology*; D011247:Pregnancy; D012756:Sheep; D014403:Tubocurarine / Q000494:pharmacology*
chemical_list: D002245:Carbon Dioxide; D010197:Pancuronium; D010100:Oxygen; D014403:Tubocurarine