Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B.
A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.
Subhashini
M
M
Department of Chemistry, Indian Institute of Technology, Madras.
Subramanian
M S
MS
Rao
V R
VR
D010131:Aminosalicylic Acid / Q000032:analysis; D001205:Ascorbic Acid / Q000032:analysis; D002700:Chloramines / Q000737:chemistry; D007202:Indicators and Reagents; D007538:Isoniazid / Q000032:analysis* / Q000737:chemistry; D012293:Rifampin / Q000032:analysis; D000096926:Benzenesulfonamides
D010131:Aminosalicylic Acid; D001205:Ascorbic Acid; D002700:Chloramines; D007202:Indicators and Reagents; D007538:Isoniazid; D012293:Rifampin; C030263:chloramine-B; D000096926:Benzenesulfonamides