Proto-oncogene c-fos is transiently induced in the rat cerebral cortex after forebrain ischemia.
The amounts of mRNAs for proto-oncogene c-fos and structural protein beta-actin were measured in the rat cerebral cortex after transient forebrain ischemia. A transient and specific induction of c-fos mRNA was noticed in the cerebral cortex 30-90 min after ischemia followed by decline to control value. In contrast, the level of mRNA for beta-actin was not altered throughout the recirculation period examined. These results suggest specific role of c-fos gene after brain damage.
Onodera
H
H
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kogure
K
K
Ono
Y
Y
Igarashi
K
K
Kiyota
Y
Y
Nagaoka
A
A
D000818:Animals; D005625:Frontal Lobe / Q000201:enzymology* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000201:enzymology*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos