Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults. Effect of starvation and thyroxine treatment.
The accumulation profile of intestinal lactase mRNA was investigated in suckling and adult rats and pigs. We found no correlation between the lactase enzymatic activity and the accumulation of the messenger at both developmental stages. Modulation of lactase activity by starvation or thyroxine treatment had no effect on lactase mRNA accumulation in the rat intestine. These results confirm that thyroxine modulates lactase expression essentially at the post-transcriptional level.
Freund
J N
JN
INSERM Unité 61, 3, Strasbourg, France.
Duluc
I
I
Raul
F
F
D000367:Age Factors; D000818:Animals; D000833:Animals, Suckling; D005215:Fasting; D005696:Galactosidases / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D007422:Intestines / Q000201:enzymology*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013552:Swine; D013974:Thyroxine / Q000008:administration & dosage; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism*
D009841:Oligonucleotides; D012333:RNA, Messenger; D005696:Galactosidases; D001616:beta-Galactosidase; D013974:Thyroxine