Lysosomal mutations increase susceptibility to anaesthetics.
The anaesthetic responses of homozygous mutant mice were compared with those of their normal heterozygous littermates. The two recessive mutations studied were beige (bg) and reduced pigmentation (rp). Homozygosity for either significantly increased the sleeping time of both sexes after treatment with pentobarbital, tribromoethanol or the steroid anaesthetic alphaxalone.
Ahmed
F
F
Department of Biology, University of Essex, Colchester, England.
Lundin
L G
LG
Shire
J G
JG
D000758:Anesthesia; D000777:Anesthetics; D000818:Animals; D000431:Ethanol; D005260:Female; D006720:Homozygote; D008247:Lysosomes / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D010424:Pentobarbital; D010858:Pigmentation / Q000235:genetics; D011277:Pregnanediones; D013997:Time Factors
D000777:Anesthetics; D011277:Pregnanediones; D000431:Ethanol; C006477:alphaxalone; D010424:Pentobarbital