Pulmonary thromboembolism associated with procainamide induced lupus syndrome and anticardiolipin antibodies.
Procainamide is the commonest cause of a drug induced lupus syndrome. Long term administration of this compound may induce a variety of immunological abnormalities, including antinuclear antibodies. Uncommonly, 'lupus anticoagulants' have been demonstrated in the absence of other evidence of drug induced lupus. Details of a 67 year old man who developed not only drug induced lupus but also antiphospholipid antibodies which were associated with multiple pulmonary thromboemboli after the administration of procainamide are recorded.
Asherson
R A
RA
Lupus Arthritis Research Unit, Rayne Institute, St Thomás Hospital, London.
Zulman
J
J
Hughes
G R
GR
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000150:complications; D008297:Male; D011342:Procainamide / Q000009:adverse effects*; D011655:Pulmonary Embolism / Q000209:etiology* / Q000276:immunology
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D011342:Procainamide