title: Immunoglobulin light chains in common acute lymphoblastic leukaemia.
abstract: A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction. Immunoglobulin mu chain was not identified in these patients. Results of immunoglobulin typing in 103 patients with B chronic lymphocytic leukaemia (B-CLL) are cited to show the increased sensitivity of the APAAP technique as compared to the indirect immunoperoxidase technique for cellular immunoglobulin identification.
authors.affiliation: Haematology Department, Belfast City Hospital.
authors.forename: G M
authors.initials: GM
authors.lastname: Markey
authors.forename: H D
authors.initials: HD
authors.lastname: Alexander
authors.forename: R L
authors.initials: RL
authors.lastname: Nolan
authors.forename: T C
authors.initials: TC
authors.lastname: Morris
authors.forename: J H
authors.initials: JH
authors.lastname: Robertson
mesh_terms: D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007223:Infant; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
chemical_list: D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains