Stability of transcription complexes on class II genes.
Commitment of a TATA box-driven class II gene to transcription requires binding of only one transcription factor, TFIID. Additional factors (TFIIB, TFIIE, and RNA polymerase II) do not remain associated with the TFIID-promoter complex during the course of transcription. This indicates that there are two intermediates along the transcription reaction pathway which may be potential targets for the regulation of gene expression.
Van Dyke
M W
MW
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
Sawadogo
M
M
Roeder
R G
RG
D000256:Adenoviridae; D004279:DNA, Viral / Q000032:analysis; D004268:DNA-Binding Proteins / Q000378:metabolism; D005802:Genes, MHC Class II; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D004279:DNA, Viral; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II