title: A myopathy of sheep associated with sarcocystis infection and monensin administration.
abstract: An outbreak of muscle disease affected approximately 20 of 600 ewes in spring 1987 in south-east Scotland. The clinical signs were a flaccid paralysis of the hind limbs and in severe cases collapse. Serum creatine kinase and aspartate aminotransferase activities were increased. Clinically affected sheep had a mean reciprocal serum antibody titre in a sarcocystis immunofluorescence antibody test of 557 whereas 22 sheep from the same flock, sampled one year earlier, showed a mean reciprocal titre of only 51. Histologically a heavy infestation of sarcocysts, myodegeneration and a non-suppurative myositis centred on degenerating sarcocysts were observed in a wide range of skeletal muscles and myocardium from four affected sheep. Monensin sodium had been inadvertently included in the protein pellet used in the feed for one week before the onset of the disease.
authors.affiliation: Lasswade Veterinary Laboratory, Penicuik, Midlothian.
authors.forename: M
authors.initials: M
authors.lastname: Jeffrey
authors.forename: J C
authors.initials: JC
authors.lastname: Low
authors.forename: A
authors.initials: A
authors.lastname: Uggla
mesh_terms: D000821:Animal Feed; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005455:Fluorescent Antibody Technique; D005506:Food Contamination; D006321:Heart / Q000469:parasitology; D008985:Monensin / Q000009:adverse effects*; D009132:Muscles / Q000469:parasitology / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D012522:Sarcocystis / Q000276:immunology; D012523:Sarcocystosis / Q000150:complications / Q000662:veterinary*; D012606:Scotland; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*
chemical_list: D000913:Antibodies, Protozoan; D008985:Monensin