title: Update on nitroglycerin use.
abstract: Tolerance to nitrates occurs when this class of drugs is administered in a continuous around-the-clock regimen. Nitrate-free intervals from 10 to 12 hours are recommended to prevent nitrate tolerance. Full response with renewed administration occurs with interrupted nitrate therapy.
authors.affiliation: Department of Medicine, University of Miami School of Medicine, FL 33101.
authors.forename: P
authors.initials: P
authors.lastname: Andrien
authors.forename: L
authors.initials: L
authors.lastname: Lemberg
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000451:nursing / Q000503:physiopathology; D004361:Drug Tolerance; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D005996:Nitroglycerin