[Definitive diagnosis of early malignant melanoma lesions by the quantitative analysis of 5-S-cysteinyldopa in the tissue and touch fluorescence method].
Methods for making diagnoses of early lesions of malignant melanomas using a touch-fluorescence method from the cut surface of the lesions and quantitative analysis of 5-S-CD in the tissues were developed. 1) The touch-fluorescence method and analyses of 5-S-CD values in the tissues were extremely useful in making definitive diagnoses of early lesions of nodular melanoma (NM). 2) Only quantitative analyses of 5-S-CD values in the tissues were useful in making definitive diagnoses of early lesions of superficial spreading melanoma (SSM). 3) It is impossible to definitively diagnose lentigo maligna using either way mentioned above. From these results, it appears that quantitative analysis of 5-S-CD values in the tissue was the most useful method for making definitive diagnoses in case of early lesions of NM and SSM.
Kanematsu
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S
Morishima
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T
D000293:Adolescent; D000328:Adult; D000368:Aged; D003548:Cysteinyldopa / Q000032:analysis*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D005453:Fluorescence; D006801:Humans; D008297:Male; D008545:Melanoma / Q000032:analysis / Q000175:diagnosis*; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000032:analysis / Q000175:diagnosis*
D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine