title: Magnesium alters the potency of cocaine and haloperidol on mouse aggression.
abstract: Magnesium has been shown to have certain behavioral effects similar to the stimulants cocaine and amphetamine, particularly on mouse resident-intruder aggression. Consequently, it was hypothesized that magnesium should interact with the indirect agonist cocaine and the antagonist haloperidol to alter their potency in the mouse resident-intruder model. Acute and chronic drug effects were compared. Results demonstrate an enhancement of cocaine potency by 30 and 125 mg/kg MgCl2 and a lowering of cocaine potency by a 15% required-Mg2+ deficient diet as measured by shifts in the dose response to acutely administered cocaine. Following chronic 0.5 mg/kg cocaine for 15 days, a dose of 125 mg/kg acutely administered MgCl2 prevented the disruptive effects of chronic cocaine on mouse aggression. Acutely administered haloperidol was influenced by Mg2+ treatments in a manner opposite from the effects on cocaine, while the chronic effects of haloperidol were affected in the same manner by Mg2+ treatments as those shown for chronic cocaine. Several mechanisms are suggested to explain these interactions.
authors.affiliation: Department of Psychology, Boston University, MA 02215.
authors.forename: K M
authors.initials: KM
authors.lastname: Kantak
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000523:psychology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013997:Time Factors
chemical_list: D008274:Magnesium; D003042:Cocaine; D006220:Haloperidol