[Effect of preliminary administration of alpha-tocopherol and intal on the course of experimental myocardial necrosis].
Morphofunctional state of myocardial capillary bed and serum creatine kinase were measured in 70 white rats with coronary arterial occlusion. Four-day pretreatment with alpha-tocopherol and, particularly, intal, was conductive to the improvement of micro-circulation in the ischemized myocardium via an increase in the number, exchange surface area and capacity of functional capillaries. This effect became manifest since day 1 after coronary arterial occlusion and was accompanied by a stabilization of the creatine kinase level. The fact that the effect of intal was of basically the same type, but more pronounced, as compared to that of alpha-tocopherol, might be due to both the similarity of the drugs in terms of nonspecific antioxidant effect and specific properties of intal which has a membrane-protective effect on the mast cell, normalizing its stress-induced activation.
Matevosian
R Sh
RSh
Amatuni
V G
VG
D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D011292:Premedication; D051381:Rats; D014810:Vitamin E / Q000008:administration & dosage*
D014810:Vitamin E; D004205:Cromolyn Sodium
Vliianie predvaritel'nogo vvedeniia alpha-tokoferola i intala na techenie eksperimental'nogo nekroza miokarda.