[Interchangeability of mutagens during fractionated effects of unequal concentrations of alkylating agents].
The ability of thiophosphamide and dipin to substitute for each other in "clastogenic adaptation" of human lymphocytes was investigated at Go phase. There were used 5 low concentrations of mutagens 2, 0.2, 2.10(-2), 2.10(-3), 2.10(-4) micrograms/ml and the high one of 20 micrograms/ml with which cells were treated 2 hr after the effect of low concentrations. The "protective" concentrations for both mutagens were 0.2, 2.10(-2), 2.10(-3) micrograms/ml. The pretreatment with thiophosphamide caused the decrease in chromatid aberrations in "challenge" treatment with dipin, the pretreatment with dipin caused the decrease in chromosome aberrations in "challenge" treatment with thiophosphamide.
Tulina
A N
AN
Chebotarev
A N
AN
D000477:Alkylating Agents / Q000494:pharmacology*; D001388:Aziridines / Q000008:administration & dosage / Q000494:pharmacology; D002478:Cells, Cultured; D002842:Chromatids; D002869:Chromosome Aberrations; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens; D013852:Thiotepa / Q000008:administration & dosage / Q000494:pharmacology
D000477:Alkylating Agents; D001388:Aziridines; D009153:Mutagens; D013852:Thiotepa; C007526:dipin
Vzaimozameniaemost' mutagenov pri fraktsionirovannom vozdeĭstvii neravnymi kontsentratsiiami alkiliruiushchikh agentov.