The longitudinal observation of the effect of antibiotics on human tear lysozyme activity.
It is well known that lysozyme, which catalyzes the hydrolysis of bacterial cell walls, is one of the important substances protecting the eye surface from bacterial infections. It was reported that the aminoglycoside antibiotics strongly inhibited the tear lysozyme activity. The lysozyme activity of tears which were added to different concentrations of two aminoglycoside antibiotics and three other antibiotics was determined longitudinally. No influence of any antibiotics on tear lysozyme activity was found. Therefore it is unnecessary to worry about that the use of aminoglycoside antibiotics may weaken the defence function of the eye.
Yang
P Z
PZ
Zhang
X F
XF
Zhang
J S
JS
Wu
Y D
YD
Shi
R H
RH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008137:Longitudinal Studies; D009113:Muramidase / Q000037:antagonists & inhibitors*; D013666:Tears / Q000187:drug effects* / Q000201:enzymology
D000900:Anti-Bacterial Agents; D009113:Muramidase