title: Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin.
abstract: Spontaneous mutants of Pseudomonas aeruginosa selected by ciprofloxacin were studied for outer membrane alterations. Acquisition of ciprofloxacin resistance was at least partially related to defects in lipopolysaccharide synthesis. When ciprofloxacin resistance was combined with resistance to beta-lactams and aminoglycosides, several alterations in outer membrane proteins were noted.
authors.affiliation: Department of Microbiology, School of Health Sciences, Goudi, Athens, Greece.
authors.forename: N J
authors.initials: NJ
authors.lastname: Legakis
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: A
authors.initials: A
authors.lastname: Makris
authors.forename: H
authors.initials: H
authors.lastname: Kotsifaki
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D001425:Bacterial Outer Membrane Proteins; D002939:Ciprofloxacin