Elevated aminotransferases and alkaline phosphatases in unstable diabetes mellitus without ketoacidosis or hypoglycemia.
Four patients with unstable diabetes mellitus and pronounced elevations of serum aminotransferases and alkaline phosphatases are reported. Thorough investigations revealed no cause for the abnormalities. The enzyme elevations were associated with hepatomegaly, and in some instances, abdominal pain and leg edema. Liver biopsies in all patients showed only marked accumulation of glycogen in the hepatocytes.
Olsson
R
R
Department of Internal Medicine I, Sahlgrenska University Hospital, Göteborg, Sweden.
Wesslau
C
C
William-Olsson
T
T
Zettergren
L
L
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001706:Biopsy; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000473:pathology; D016883:Diabetic Ketoacidosis; D005260:Female; D006529:Hepatomegaly / Q000473:pathology; D006801:Humans; D007003:Hypoglycemia; D008099:Liver / Q000473:pathology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male
D008112:Liver Glycogen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase