[The effect of vitamin A and Astragalus on the splenic T lymphocyte-CFU of burned mice].
In present study the effects of vitamin A and Astargalus on the splenic TL-CFU of mice were studied by means of T-lymphocytes colony formation in semi-solid culture in vitro and incorporation of 3H-TdR. Marked reduction of the responsive reaction of TL-CFU and T-lymphocyte transformation were found. The TL-CFU of the experimentally burned mice untreated with vitamin A (i.e. group 1) were significantly inhibited (p less than 0.005) in comparison with the unburned control group (i.e. group 4). And the TL-CFU of the experimentally burned mice treated with vitamin A (i.e. group 3) increased significantly (p less than 0.005) in comparison with group 1. Incorporation of 3H-TbR showed that vitamin A might accelerate the proliferation of the TL-CFU of the burned mice. It means that vitamin A might be regarded as an effective agent for the reversal of the inhibition of cell-mediated immunity in post-burned state, whether Ahstragalus plays a role in regulating immune inhibition needs further investigation.
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D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000276:immunology; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000473:pathology; D013234:Stem Cells / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*; D014801:Vitamin A / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D014801:Vitamin A