title: Severe thrombotic tendency associated with a type I plasminogen deficiency.
abstract: We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, electrophoretic mobility on crossed immunoelectrophoresis, molecular weight, and binding to lysine sepharose. All other hemostatic parameters predisposing to recurrent thrombosis were normal. A stimulation test with desmopressin acetate (DDAVP) showed a normal plasma rise of both tissue plasminogen activator and factor VIIIR:WF. This isolated plasminogen deficiency apparently is due to a decreased synthesis of a normal plasminogen molecule and is associated with a severe thrombotic tendency.
authors.affiliation: Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands.
authors.forename: F W
authors.initials: FW
authors.lastname: Leebeek
authors.forename: E A
authors.initials: EA
authors.lastname: Knot
authors.forename: J W
authors.initials: JW
authors.lastname: Ten Cate
authors.forename: D W
authors.initials: DW
authors.lastname: Traas
mesh_terms: D003894:Deamino Arginine Vasopressin; D005260:Female; D006487:Hemostasis; D006801:Humans; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis / Q000097:blood / Q000172:deficiency*; D013924:Thrombophlebitis / Q000097:blood / Q000150:complications*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D003894:Deamino Arginine Vasopressin