title: Inhibition of human placenta aldose reductase by tannic acid.
abstract: Tannic acid was found to be a highly potent inhibitor of human placenta aldose reductase. The most potent inhibitory component of the tannic acid was isolated and identified as penta-O-galloyl-beta-D-glucose, which showed an IC50 value of 70 nM. The inhibition by the gallotannin was reversible and of mixed type with respect to DL-glyceraldehyde as the varied substrate.
authors.forename: H
authors.initials: H
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Hamatake
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D066298:In Vitro Techniques; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013634:Tannins / Q000494:pharmacology*
chemical_list: D047348:Hydrolyzable Tannins; D013634:Tannins; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase