title: Spontaneous release of interleukin-1 (IL-1) from medullary mononuclear cells of pagetic subjects.
abstract: The Authors examined interleukin 1 (IL-1) secretion from the peripheral and medullary mononuclear cells, obtained with sequential separation on Ficoll-Hypaque and 45% Percoll gradient, in 6 pagetic subjects and 6 normal controls. Both peripheral and medullary cells from pagetic subjects showed a significantly greater IL-1 production after stimulation with lipopolysaccharides (LPS); moreover, we observed a spontaneous IL-1 release from medullary cells in pagetic subjects but not in normal controls. These findings suggest a possible role of IL-1 in the elevated bone turnover of Paget's disease of bone.
authors.affiliation: Cattedra di Clinica Medica II, Universitá di Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pioli
authors.forename: G
authors.initials: G
authors.lastname: Girasole
authors.forename: M
authors.initials: M
authors.lastname: Pedrazzoni
authors.forename: P
authors.initials: P
authors.lastname: Sansoni
authors.forename: A
authors.initials: A
authors.lastname: Erroi
authors.forename: L
authors.initials: L
authors.lastname: Davoli
authors.forename: G
authors.initials: G
authors.lastname: Ciotti
authors.forename: A
authors.initials: A
authors.lastname: Mantovani
authors.forename: M
authors.initials: M
authors.lastname: Passeri
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000378:metabolism*
chemical_list: D007375:Interleukin-1