Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.
The transgenic mice were produced by injecting eggs of B6 and C3H/HeJ mice with the human E mu-myc gene. Preferential development of B lymphomas was observed in the B6 transgenic mice, whereas the C3H/HeJ transgenic mice developed mostly T lymphomas. The phenotypic activation of B lineage cells but not of T lineage cells was detected in the prelymphomatous transgenic mice of both strains. The transgene was similarly expressed in B and T cells of the transgenic mice of both strains. These results suggest that a high incidence of T lymphomas in the C3H/HeJ transgenic mice may not be due to the preferential activation of or the preferential E mu-myc expression in T lymphocytes. When the bone marrow or fetal liver cells from the prelymphomatous transgenic mice of both strains were transferred into irradiated normal C3H/HeJ mice, most of the recipients developed T lymphomas. Moreover, even when irradiated B6 mice received the hematopoietic stem cells from the prelymphomatous B6 transgenic mice, the incidence of T lymphoma increased up to 50%. These findings suggest that B6 and C3H/HeJ mice might provide the environment that supports the development or growth of B and T lymphomas, respectively, and that such an environment could be modified by irradiation of the mice.
Yukawa
K
K
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Kikutani
H
H
Inomoto
T
T
Uehira
M
M
Bin
S H
SH
Akagi
K
K
Yamamura
K
K
Kishimoto
T
T
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D016026:Bone Marrow Transplantation; D016827:CD8 Antigens; D004742:Enhancer Elements, Genetic; D005803:Genes, Immunoglobulin; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D013045:Species Specificity
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D012333:RNA, Messenger