The effects of prostaglandins on gastric emptying.
This review summarizes the effects of prostaglandins on gastric emptying in animals and man. It appears that prostaglandin E2 (PGE2) and prostaglandin F2 alpha increase the rate of gastric emptying in animals. PGE2 increases the emptying of liquids from the human stomach; more recently developed prostaglandin analogues, however, such as misoprostil and trimoprostil, have no effect on the rate of emptying of the human stomach. The PGE1 analogue, rioprostil, increases the rate of emptying of an acid load from the stomach; it does not, however, affect gastric emptying of a meal consisting of meat broth and glucose. It is concluded that prostaglandins do not affect the rate of gastric emptying of solids, but that some of these compounds do increase gastric emptying of liquids in both animals and man.
Penston
J G
JG
Department of Therapeutics, University of Dundee, Scotland, UK.
Wormsley
K G
KG
D000328:Adult; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D016630:Rioprostil
D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil