title: [Results of clinical trials with the gluconeogenesis inhibitor 2-(3-methylcinnamylhydrazono)-propionate (MCHP)].
abstract: Many compounds which directly or indirectly inhibit gluconeogenesis have been described. Some of them showed hypoglycemic action in animal experiments. 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP) a derivative of hydrazine demonstrated marked hypoglycemic action in animal experiments. Nontheless the administration of MCHP to type II diabetic patients showed no hypoglycemic action. Clinical or biochemical sideeffects could not be observed.
authors.affiliation: II. Medizinische Klinik, Klinkum Mannheim der Universität Heidelberg, Mannheim.
authors.forename: R
authors.initials: R
authors.lastname: Paschke
authors.forename: U
authors.initials: U
authors.lastname: Schwedes
authors.forename: H
authors.initials: H
authors.lastname: Kühnle
authors.forename: J
authors.initials: J
authors.lastname: Peter
authors.forename: R
authors.initials: R
authors.lastname: Schmeidl
authors.forename: K H
authors.initials: KH
authors.lastname: Usadel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002934:Cinnamates / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005943:Gluconeogenesis / Q000187:drug effects*; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D002934:Cinnamates; D007004:Hypoglycemic Agents; C039804:BM 42304; D005905:Glyburide
vernacular_title: Ergebnisse der klinischen Prüfung des Glukoneogenesehemmers 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP).