Immune response against P815X2 mastocytoma growing in syngeneic DBA/2 mice. VI. Histamine-induced suppression of in vitro generation of tumour-specific cytotoxic T cells.
Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time of cytotoxic peak reaction (between days 12 and 16 after P815X2 inoculation), the spleen cells were more resistant to histamine than the spleen cells obtained from mice a few days before or a few days after maximal cytotoxicity. Histamine had no effect on the effector function of in-vitro-generated cytotoxicity. The results suggest histamine-induced modulation of cytotoxic T-cell reactions in P815X2-bearing mice.
Laatikainen
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Department of Clinical Microbiology, University of Kuopio, Finland.
D000818:Animals; D000917:Antibody Formation; D006632:Histamine / Q000494:pharmacology* / Q000502:physiology; D007165:Immunosuppression Therapy; D007700:Kinetics; D008297:Male; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D008937:Mitomycins / Q000494:pharmacology; D009368:Neoplasm Transplantation; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D008937:Mitomycins; D006632:Histamine