Maternal free thyroxine and thyroxine-binding globulin during pregnancy ending in congenital malformations in the offspring.
Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group A showed no significant difference in TBG values compared to women with healthy children. Group B showed lower, but not significantly lower values in earlier pregnancy. However, from the 15th-16th week of pregnancy the TBG values were significantly lower. The FT4 values were in the hyperthyroid range in as much as 20% of the women, compared to the reported rate of 0.2% hyperthyroidism in pregnant women.
Skjöldebrand Sparre
L S
LS
Department of Obstetrics and Gynecology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000097:blood*
D013975:Thyroxine-Binding Proteins; D013974:Thyroxine