Monoclonal immunoglobulin deposition disease in a renal allograft: probable recurrent disease in a patient without myeloma.
A case in which monoclonal IgG-kappa deposition in the glomeruli of a renal allograft apparently resulted in graft failure is described. Review of biopsy material obtained from the patient's native kidney biopsy indicates a high probability that this glomerulopathy represents recurrent disease in the allograft. The reported transplantation experience with this entity (monoclonal immunoglobulin deposition disease; light-chain nephropathy) is limited; this case indicates the potential for disease recurrence even in the absence of a systemic lymphoplasmacytic disorder.
Alpers
C E
CE
Department of Pathology, University of Washington, Seattle.
Marchioro
T L
TL
Johnson
R J
RJ
D000328:Adult; D001706:Biopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006084:Graft Rejection; D006801:Humans; D007147:Immunoglobulin Light Chains; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008854:Microscopy, Electron; D009101:Multiple Myeloma; D012008:Recurrence
D007147:Immunoglobulin Light Chains