title: Blunted growth hormone response to peripheral infusion of human growth hormone-releasing factor in patients with panic disorder.
abstract: Patients with panic disorder (N = 11) and age- and sex-matched normal control subjects (N = 11) were challenged with human growth hormone-releasing factor (GH-RF) (1 microgram/kg i.v.) or placebo in random order. The control subjects had significantly increased plasma growth hormone (GH) levels after GH-RF infusion whereas panic disorder patients did not. At 15 and 30 minutes after GH-RF infusion, GH concentrations were significantly higher in the control subjects than in the patients. These findings with GH-RF extend findings from earlier reports that patients with panic disorder show blunted GH response to phobic stimulation and clonidine.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla.
authors.forename: M H
authors.initials: MH
authors.lastname: Rapaport
authors.forename: S C
authors.initials: SC
authors.lastname: Risch
authors.forename: J C
authors.initials: JC
authors.lastname: Gillin
authors.forename: S
authors.initials: S
authors.lastname: Golshan
authors.forename: D S
authors.initials: DS
authors.lastname: Janowsky
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000097:blood* / Q000175:diagnosis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010698:Phobic Disorders / Q000097:blood*; D011897:Random Allocation
chemical_list: D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone