Fine structural changes in the rat brain after local injections of gliotoxin, alpha-aminoadipic acid.
Toxic effects of locally injected gliotoxin, L-alpha-aminoadipic acid, were examined in the adult rat brain at the fine structural level. Astrocytes were the only cell type in the corpus striatum that showed clear structural degeneration 1 to 3 days after the treatment. With a 7 day survival period, two major structural changes were detectable, including tremendous invasion of astrocytes and their processes, and an appearance of a large number of microglia around injection sites. Both the stereospecificity and cellular specificity were firmly established on the toxic effects of this chemical.
Takada
M
M
Department of Anatomy, University of Toronto, Ontario, Canada.
Hattori
T
T
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000648:ultrastructure; D003342:Corpus Striatum / Q000187:drug effects / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D005912:Gliotoxin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D014793:Visual Cortex / Q000187:drug effects* / Q000648:ultrastructure
D015074:2-Aminoadipic Acid; D005912:Gliotoxin