title: A comparison of enflurane with alfentanil anaesthesia for gynaecological surgery.
abstract: Forty patients undergoing gynaecological surgery were randomly assigned to receive either alfentanil and thiopentone for induction of anaesthesia, followed by alfentanil-N2O/O2 (60%/40%) for maintenance of anaesthesia, or low-dose fentanyl and thiopentone, followed by enflurane-N2O/O2 (60%/40%). More patients given enflurane developed a tachycardia (P less than 0.03) and 20% decreases in systolic and diastolic blood pressure. Times to recovery were significantly shorter after alfentanil than after enflurane. Plasma concentrations of alfentanil during induction suggested that haemodynamic and catecholamine responses were either less than, or did not differ from, baseline levels when the plasma concentration of the drug exceeded 150 ng ml-1. At extubation and the beginning of spontaneous breathing, the plasma concentration was 278 +/- 129 ng ml-1. Values for pharmacokinetic parameters of alfentanil were as follows: clearance, 5.2 +/- 2.0 ml kg-1 min-1; volume of distribution, 0.63 +/- 0.20 1 kg-1; and elimination half-life, 96.9 +/- 52.5 min. Two patients who had extended surgery had significantly lower plasma clearance of alfentanil and increased half-life. The authors conclude that the alfentanil technique was preferable to maintenance with enflurane.
authors.affiliation: Department of Anesthesiology, Ohio State University Hospitals, Columbus 43210-1228.
authors.forename: M B
authors.initials: MB
authors.lastname: Howie
authors.forename: L J
authors.initials: LJ
authors.lastname: Hoffer
authors.forename: J
authors.initials: J
authors.lastname: Kryc
authors.forename: J S
authors.initials: JS
authors.lastname: McDonald
authors.forename: R R
authors.initials: RR
authors.lastname: Dzwonczyk
authors.forename: J
authors.initials: J
authors.lastname: Reitz
authors.forename: T D
authors.initials: TD
authors.lastname: McSweeney
mesh_terms: D000328:Adult; D015760:Alfentanil; D000777:Anesthetics / Q000493:pharmacokinetics / Q000494:pharmacology; D001285:Atropine / Q000008:administration & dosage; D004569:Electroencephalography; D004737:Enflurane / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D005836:Genitalia, Female / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D011229:Preanesthetic Medication
chemical_list: D000777:Anesthetics; D015760:Alfentanil; D001285:Atropine; D004737:Enflurane; D005283:Fentanyl