title: Ponalrestat: a potent and selective inhibitor of bovine lens aldose reductase.
authors.affiliation: ICI Pharmaceuticals Division, Macclesfield, Cheshire, U.K.
authors.forename: D P
authors.initials: DP
authors.lastname: Tuffin
authors.forename: A
authors.initials: A
authors.lastname: Dingle
authors.forename: C M
authors.initials: CM
authors.lastname: Sennitt
authors.forename: D J
authors.initials: DJ
authors.lastname: Mirrlees
authors.forename: W H
authors.initials: WH
authors.lastname: Ward
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007700:Kinetics; D007908:Lens, Crystalline / Q000201:enzymology*; D008433:Mathematics; D015394:Molecular Structure; D010793:Phthalazines; D013379:Substrate Specificity; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
chemical_list: D007004:Hypoglycemic Agents; D010793:Phthalazines; C042829:ponalrestat; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; D000445:Aldehyde Oxidoreductases