Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls.
We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 induces cytochrome P-452-linked enzyme activities in rats, but not in pigeons. This inductive effect was previously regarded as being specific for hypolipidemic drugs and phthalate ester plasticisers.
Borlakoglu
J T
JT
Department of Biochemistry & Physiology, University of Reading, Whiteknights, England.
Edwards-Webb
J D
JD
Dils
R R
RR
Wilkins
J P
JP
Robertson
L W
LW
D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D010856:Columbidae; D003580:Cytochromes / Q000096:biosynthesis*; D005260:Female; D006900:Hydroxylation; D007850:Lauric Acids / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
D001140:Aroclors; D003580:Cytochromes; D007850:Lauric Acids; D020111:Chlorodiphenyl (54% Chlorine); C030358:lauric acid; C046362:cytochrome P-452; D011078:Polychlorinated Biphenyls