Isolation of CB-25-I, an antifungal antibiotic, from Serratia plymuthica.
A new antifungal antibiotic, CB-25-I, was isolated from the culture broth of a strain of Serratia plymuthica. The antibiotic, a water-soluble dipeptide, is structurally related to Sch 37137 and A 19009, both produced by strains of Actinomycetales. The antibiotic exhibits inhibitory activity against Candida albicans in YNB medium (a synthetic medium), but the activity is significantly reduced in Sabouroud dextrose medium.
Shoji
J
J
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Hinoo
H
H
Sakazaki
R
R
Kato
T
T
Hattori
T
T
Matsumoto
K
K
Tawara
K
K
Kikuchi
J
J
Terui
Y
Y
D000596:Amino Acids / Q000032:analysis; D000599:Amino Acids, Diamino / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003470:Culture Media; D005285:Fermentation; D006868:Hydrolysis; D005779:Immunodiffusion; D009682:Magnetic Resonance Spectroscopy; D012705:Serratia / Q000145:classification / Q000378:metabolism*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared
D000596:Amino Acids; D000599:Amino Acids, Diamino; D000935:Antifungal Agents; D003470:Culture Media; C060105:N-(3-(((-3-(aminocarbonyl)oxiranyl)carbonyl)amino)alanyl)valine