Antiviral activity in urine is attributable to ammonium salts.
Urine exhibits antiviral activity in tissue culture against a number of viruses. We have characterized that antiviral activity in comparison with a number of antiviral substances which are known to be present in body fluids. We show here that the antiviral activity in urine cannot be due to the presence of contact-blocking virus inhibitor (CVI), or interferon. The findings support the conclusion that most of the antiviral activity in urine is qualitatively and quantitavely attributable to its content of ammonium salts.
Baron
S
S
Department of Microbiology, University of Texas Medical Branch, Galveston.
Sabados
J
J
McKerlie
M L
ML
Coppenhaver
D H
DH
D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology*; D002852:Chromatography, Ion Exchange; D006801:Humans; D007231:Infant, Newborn; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014556:Urine / Q000502:physiology*; D014762:Viral Interference; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D007370:Interferon Type I; D000644:Quaternary Ammonium Compounds; D007371:Interferon-gamma