Biological activity of some Schiff bases and their metal complexes.
Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity. The compound salicylidene-anthranilic acid (SAA) was found to possess the antiinflammatory and antiulcer activity. The copper complexes showed an increased antiulcer activity. The SAA is perhaps acting by influencing prostaglandin biosynthesis.
Parashar
R K
RK
Department of Chemistry, Agra University, India.
Sharma
R C
RC
Mohan
G
G
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis; D002368:Castor Oil; D002614:Chelating Agents / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D009532:Nickel / Q000494:pharmacology; D051381:Rats; D012545:Schiff Bases / Q000138:chemical synthesis / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D002614:Chelating Agents; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D002368:Castor Oil