The effect of 4-aminopyrazolo (3,4-d) pyrimidine (4-APP) on some parameters of carbohydrate metabolism in the rat.
The study was designed to evaluate some parameters of carbohydrate metabolism in the rat as influenced by 4-APP, an adenine analogue. Adult female rats were injected with 1 mg 4-APP/100 g body weight/day for 3 days. 4-APP evoked a marked enlargement of the liver with lipid droplets accumulation in hepatocytes. This was accompanied by a marked lowering of the liver glycogen content. Within 3 days 4-APP did not change serum glucose, insulin and free fatty acid concentration. Serum glycogenolytic activity studied in an in vitro system showed 7 times as high glucose releasing ability in 4-APP treated rats as that of the serum of control animals. 4-APP resulted also in a marked enlargement of the adrenal medulla and lowered adrenaline and noradrenaline concentrations in the gland. The possibility of an activation of glycogenolysis in the liver of 4-APP treated rats has been discussed.
Torlińska
T
T
Department of Physiology, School of Medicine, Poznań.
Malendowicz
L K
LK
Paluszak
J
J
Koźlik
J
J
Nowak
M
M
Nowak
K W
KW
Godlewski
J
J
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D006003:Glycogen / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
C004420:4-aminopyrazolo(3,4-d)pyrimidine; D006003:Glycogen; D000225:Adenine