title: Generalized seizures as the presentation of flecainide toxicity.
abstract: A 12-year-old girl developed generalized tonic-clonic seizures following ingestion of flecainide 1500 mg (15 tablets). At presentation, the electrocardiogram showed marked prolongation of the JT interval and marked increase in QRS duration. The initial plasma flecainide level was greater than 4 micrograms ml-1. Supportive therapy was instituted and complete recovery occurred within 48 h. The electrocardiogram returned to normal. The management of class 1 antiarrhythmic agent toxicity is briefly outlined and the association of antiarrhythmic drug toxicity with seizures is reviewed.
authors.affiliation: Department of Cardiology, St. Mary's Hospital Medical School, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Kennerdy
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: D J
authors.initials: DJ
authors.lastname: Sheridan
mesh_terms: D002648:Child; D062787:Drug Overdose / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000009:adverse effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*
chemical_list: D005424:Flecainide