[Synthesis of 11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)] dodeca-5,9-dien-8-ol].
Structural reconstruction from natural non-alkaloidal compounds might lead to new bioactivity. In this paper, the synthesis of one of such compounds--11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)]dodeca-5, 9-dien-8-ol was reported. The compound was derived from curcumol via a tropone compound as an intermediate and was found to have an activity of markedly lowering blood pressure in anesthetized rats.
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D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000138:chemical synthesis*; D051381:Rats
D000959:Antihypertensive Agents; D004224:Diterpenes; C062552:11-aminomethyl-2,6-dimethyl-3,9-diisopropyltricyclo(5.3.2.0)dodeca-5,9-dien-8-ol