[Glucagon is processed to the (19-29) fragment at the level of the hepatocyte membrane].
Upon incubation with hepatic plasma membranes, glucagon is processed into its (19-29) C-terminal fragment. This suggests that, in physiological conditions, glucagon is processed in a target tissue at the level of its Arg17-Arg18 basic doublet, leading to the production of a fragment which is known to display an original biological specificity, namely the modulation of the calcium pump present in hepatocyte plasma membrane.
Blache
P
P
Centre C.N.R.S.-I.N.S.E.R.M. de Pharmacologie-Endocrinologie, Montpellier.
Kervran
A
A
Dufour
M
M
Martinez
J
J
Le-Nguyen
D
D
Lotersztajn
S
S
Pavoine
C
C
Pecker
F
F
Bataille
D
D
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005934:Glucagon / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D010443:Peptide Chain Termination, Translational; D010446:Peptide Fragments / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats
D010446:Peptide Fragments; D005934:Glucagon
Le glucagon est maturé en fragment (19-29) au niveau de la membrane hépatocytaire.