Singlet oxygen formation in monomeric and aggregated porphyrin c.
The absorption and fluorescence spectra of monomeric and aggregated species present in aqueous solutions of porphyrin c have been resolved by steady-state and time-resolved spectroscopy. The dependence of the singlet oxygen formation yield (phi delta) on excitation wavelength has also been determined. In the Q-band spectral region, the aggregate absorption and emission spectra are shifted to longer wavelengths with respect to the monomer spectrum with phi delta (monomer) = 0.59 and phi delta (aggregate) = 0.33. The relevance of these findings to the optimization of irradiation conditions in tumour phototherapy using porphyrin c are discussed.
Bennett
L E
LE
Department of Physical Chemistry, University of Melbourne, Victoria, Australia.
Ghiggino
K P
KP
Henderson
R W
RW
D055598:Chemical Phenomena; D002621:Chemistry; D010100:Oxygen / Q000378:metabolism*; D010789:Phototherapy; D011166:Porphyrins / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D011166:Porphyrins; C033886:porphyrin c; D010100:Oxygen