B cell suppressing and CD8+ T cell enhancing effects of photosensitive dye platonin in humans.
Platonin is one of the photosensitive dyes of trithiazole pentamethine cyanine. It is used as an effective medicine for rheumatoid arthritis. In our study, platonin suppressed the immunoglobulin (Ig) production of human peripheral blood lymphocytes (PBL) stimulated by Staphylococcus aureus Cowan I (SAC) or pokeweed mitogen (PWM). It also suppressed the PWM induced Ig production of B cells when T cells and/or B cells were pretreated with platonin, respectively. The percentage of CD8+ T cells was increased by platonin. Our results suggest that platonin suppresses Ig production through suppressing B cells and enhancing CD8+ (suppressor/cytotoxic) T cells.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine, Japan.
Ko
H
H
Motoyoshi
F
F
Orii
T
T
D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016827:CD8 Antigens; D002452:Cell Count / Q000187:drug effects; D004396:Coloring Agents; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D004396:Coloring Agents; D007136:Immunoglobulins; D011043:Pokeweed Mitogens; D013844:Thiazoles; C032149:platonin