title: Failure of canine islet allotransplantation after kidney transplantation.
abstract: Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allografts (48.5 days, P less than .05). Three of the eight dogs that received sequential kidney and islet allografts had experienced no kidney-graft rejection episodes before islet transplantation, but their islet grafts were all rejected within 19 days. In the pancreatectomized dog, prior donor-specific kidney transplantation has an adverse effect on subsequent islet-graft survival.
authors.affiliation: Department of Surgery, Medical School, Newcastle upon Tyne, England, United Kingdom.
authors.forename: A J
authors.initials: AJ
authors.lastname: Guy
authors.forename: S M
authors.initials: SM
authors.lastname: Griffin
authors.forename: D
authors.initials: D
authors.lastname: Alderson
authors.forename: J R
authors.initials: JR
authors.lastname: Farndon
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D004285:Dogs; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins