Antibiotics from basidiomycetes. XXXI. Aleurodiscal: an antifungal sesterterpenoid from Aleurodiscus mirabilis (Berk. & Curt.) Höhn.
Aleurodiscal, an antifungal antibiotic has been isolated from mycelial cultures of Aleurodiscus mirabilis (Berk. & Curt.) Höhn. It causes abnormal apical branchings of Mucor miehei hyphae at very low concentrations. The structure and absolute configuration of the antibiotic has been determined by a single crystal X-ray analysis and hydrolysis to D-(+)-xylose. Aleurodiscal is a hydroxysesterterpene aldehyde beta-D-xyloside with a novel carbon skeleton.
Lauer
U
U
Lehrbereich Biotechnologie der Universität, Kaiserslautern, FRG.
Anke
T
T
Sheldrick
W S
WS
Scherer
A
A
Steglich
W
W
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005779:Immunodiffusion; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects*; D014961:X-Ray Diffraction
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C060106:aleurodiscal