Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application.
Short-term parenteral application of vitamin A was examined in rats. Retinyl margarinate, which is chemically similar to physiological retinyl esters, was used in vitamin A-depleted rats to study uptake, distribution, and storage of retinyl esters in tissues. Vitamin A-depleted and Vitamin A-sufficient rats were infused with a micellar suspension of retinyl margarinate for 7 h and then killed at different times. Retinyl margarinate was directly taken up by all tissues examined. It appears that infusion of retinyl esters in micellar form provides a direct way to supply vitamin A to peripheral, vitamin A-dependent tissues. Therefore, a short-term infusion of retinyl esters with an emulsifier may be an effective means of preventing development of vitamin A-deficiency during long-term application of TPN, particularly in cases of liver dysfunction.
Gerlach
T
T
Department of Physiological Chemistry, University of Mainz, FRG.
Biesalski
H K
HK
Weiser
H
H
Haeussermann
B
B
Baessler
K H
KH
D000818:Animals; D002845:Chromatography / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010289:Parenteral Nutrition, Total; D051381:Rats; D000084562:Retinyl Esters; D013154:Spleen / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution; D014132:Trachea / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics*; D014802:Vitamin A Deficiency / Q000378:metabolism
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate