Kinetic determination of propranolol in tablets by oxidation with ceric sulphate.
A simple and accurate kinetic method for the determination of propranolol has been developed. Cerium(IV) sulphate (0.5 M) is used to oxidize propranolol in 2 M sulphuric acid at room temperature to the ketone form that absorbs light at a lambda max of 525 nm. The fixed-concentration method is used by recording the exact time, t(s), taken for the reaction to reach a fixed absorbance of 0.100. The unknown concentration, c(M), of propranolol is calculated from the equation: l/t = 0 0.000217 + 0.03 c. The method has been applied to the determination of propranolol in proprietary tablets and the results were compared with those obtained by the B.P. and other standard methods.
Sultan
S M
SM
Chemistry Department, King Fahd University, Dhahran, Saudi Arabia.
Altamrah
S A
SA
Aziz Alrahman
A M
AM
Alzamil
I Z
IZ
Karrar
M O
MO
D007202:Indicators and Reagents; D007700:Kinetics; D010084:Oxidation-Reduction; D011433:Propranolol / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013464:Sulfuric Acids; D013607:Tablets
D007202:Indicators and Reagents; D013464:Sulfuric Acids; D013607:Tablets; C042259:ceric sulfate; D011433:Propranolol