Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts.
Interleukin-1 alpha and beta are polypeptide hormones with a broad range of biological activities. Both interleukins are recognized by a receptor that has been characterized as a member of the immunoglobin superfamily. The interleukin-1 receptor does not appear to be a tyrosine protein kinase. Moreover, the intracellular events that mediate the multiple interleukin-1 responses are poorly understood. Here we show that the JE and KC genes, first isolated and characterized as platelet-derived growth factor inducible in quiescent BALB/c-3T3 fibroblasts, are induced by femtomolar concentrations of recombinant interleukin-1 alpha (rIL-1). The response of JE and KC to IL-1 occurs at the transcriptional level. These observations suggest that an analysis of the JE and KC transcriptional response to rIL-1 may aid in identifying elements involved in interleukin-1-mediated signal transduction
Hall
D J
DJ
Dana-Farber Cancer Institute, Harvard Medical School, Boston Massachusetts 02115.
Brownlee
C
C
Stiles
C D
CD
D000818:Animals; D001685:Biological Factors / Q000235:genetics*; D002460:Cell Line; D016207:Cytokines; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
D001685:Biological Factors; D016207:Cytokines; D007375:Interleukin-1; D010982:Platelet-Derived Growth Factor; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D013755:Tetradecanoylphorbol Acetate