Influence of dietary magnesium on the amplitude of wave V of the auditory brainstem response.
Thirty-six weanling guinea pigs were fed either a low (600 ppm) or normal (3000 ppm) diet of magnesium for 8 weeks. One half of each diet group received intramuscular injections of magnesium-depleting drugs, furosemide and gentamicin. The other half were controls and received equal intramuscular injections of saline. Auditory brainstem responses were obtained from all animals before and after 8 weeks of treatment of diet and drugs to examine the effects of treatment upon hearing and auditory brainstem function. A three-way analysis of variance of dietary magnesium, by drug and by sex, showed no significant differences in auditory brainstem wave V thresholds, wave V latencies, or interpeak wave I-V latencies between the control and experimental groups. The low magnesium diet group, which received drugs, had significantly greater wave V auditory brainstem response amplitudes. Results can be explained on the basis of magnesium influencing the uptake of calcium into both the hair cells and associated brainstem pathways.
Cevette
M J
MJ
Mayo Clinic-Scottsdale, Brigham Young University, Scottsdale, AZ 85259.
Franz
K B
KB
Brey
R H
RH
Robinette
M S
MS
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000503:physiopathology; D008274:Magnesium / Q000008:administration & dosage* / Q000502:physiology; D008275:Magnesium Deficiency / Q000503:physiopathology*; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology
D005839:Gentamicins; D005665:Furosemide; D008274:Magnesium