[Lithium found in the total brain and brain lipids after intracranial injection of lithium in mice. Relation to the observed behavior disorders].
Behavioural disturbances after lithium injection only appear in mice with concentrations above 8 microequivalents per brain. Below this value, no fixation of lithium occurs in the brain. At higher concentrations, the amount of lithium found in the brain and associated with brain lipids increases gradually to reach a plateau. Moreover, although lithium increases the extraction of proteolipids, it does not seem to have an affinity for these compounds.
Ermidou-Pollet
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Department of Biological Chemistry, University of Athens, Medical School, Greece.
Pollet
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S
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry; D004305:Dose-Response Relationship, Drug; D007267:Injections; D008055:Lipids / Q000032:analysis*; D008094:Lithium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL
D008055:Lipids; D008094:Lithium
Lithium retrouvé au niveau du cerveau total et des lipides cérébraux après injection intracrânienne de lithium chez la souris. Relation avec les troubles comportementaux observés.