[Metabolism of L-thiazolidine-4-carboxylic acid].
L-thiazolidine-(4)-carboxylic acid (TAC) has proven to be a good substrate for long-term parenteral nutrition. In this study the metabolism of TAC in the rat is examined at subcellular level. TAC is oxidized by mitochondrial proline oxidase of liver and kidney to L-thiazoline-(4)-carboxylic acid, which then is hydrolyzed to N-formyl-cysteine (FCYS). FCYS is hydrolyzed to cysteine and formic acid by a cytosolic enzyme.
Böhler
S
S
Physiologisch-Chemisches Institut, Johannes Gutenberg-Universität Mainz.
Wagner
K
K
Bässler
K H
KH
D000818:Animals; D005557:Formaldehyde / Q000493:pharmacokinetics; D008658:Inactivation, Metabolic; D007668:Kidney / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D008931:Mitochondria, Muscle / Q000201:enzymology; D010084:Oxidation-Reduction; D010289:Parenteral Nutrition, Total; D011394:Proline Oxidase / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000493:pharmacokinetics*; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; D005557:Formaldehyde; C031677:2-thioxo-4-thiazolidinecarboxylic acid; D011394:Proline Oxidase
Metabolismus der L-Thiazolidincarbonsäure-(4).