A new antitumor antibiotic, FR900840. II. Structural elucidation of FR900840.
The structure of FR900840, a new antitumor antibiotic produced by a strain of Streptomyces has been deduced as 1 on the basis of spectroscopic and chemical evidence and finally confirmed by synthesis from L-threonine and L-serine.
Nishimura
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakada
H
H
Takase
S
S
Katayama
A
A
Goto
T
T
Tanaka
H
H
Hashimoto
M
M
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006865:Hydrogenation; D006868:Hydrolysis; D006885:Hydroxybutyrates / Q000032:analysis / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012694:Serine / Q000031:analogs & derivatives / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces; D013912:Threonine / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D006885:Hydroxybutyrates; C058022:thrazarine; D013912:Threonine; D012694:Serine