title: Synthesis, properties and prodrug potential of 2-methyl-2-oxy- and 2-methyl-2-thio-4H-1,3-benzodioxin-4-ones.
abstract: The fifty-four known title compounds are fully documented and their chemical and biological properties discussed in detail. Special attention is devoted to their potential as aspirin and salicylic acid prodrugs, respectively.
authors.affiliation: Department of Chemistry, University of Aarhus, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Ankersen
authors.forename: K K
authors.initials: KK
authors.lastname: Nielsen
authors.forename: A
authors.initials: A
authors.lastname: Senning
mesh_terms: D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives*; D001592:Benzyl Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004147:Dioxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006868:Hydrolysis; D008958:Models, Molecular; D015394:Molecular Structure; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012459:Salicylates; D020156:Salicylic Acid
chemical_list: D001592:Benzyl Alcohols; D004147:Dioxins; D011355:Prodrugs; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin