title: The effect of thyroid status on the growth hormone response to growth hormone releasing hormone 1-44.
abstract: The growth hormone (GH) response to iv injection of GH releasing hormone 1-44 (GHRH 1-44) has been examined in 10 hyperthyroid and 6 hypothyroid patients. Both groups of patients were studied at presentation and when euthyroid (mean 5 months for hyperthyroid, 8 months for hypothyroid). Hyperthyroid subjects demonstrated a peak mean (+/- SE) level of 17.7 +/- 3.8 mU/l, with an integrated GH 29.3 +/- 6.4 mU/l.h. When euthyroid the peak mean level was 17.0 +/- 5.0 mU/l and the integrated GH 22.8 +/- 4.2 mU/l.h. Neither change was statistically significant. Hypothyroid subjects had a peak mean level of 5.0 +/- 2.7 mU/l and integrated GH of 5.9 +/- 1.7 mU/l.h and when euthyroid a peak mean level of 7.1 +/- 4.8 mU/l and integrated GH of 8.1 +/- 3.6 mU/l.h. Body weight did not change significantly in this group of hypothyroid subjects with prolonged treatment. The increase in GH response to GHRH previously reported following replacement therapy may reflect a treatment-induced decrease in body weight, or may be a short term effect.
authors.affiliation: Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne.
authors.forename: R R
authors.initials: RR
authors.lastname: Davies
authors.forename: S
authors.initials: S
authors.lastname: Dagogo-Jack
authors.forename: S J
authors.initials: SJ
authors.lastname: Turner
authors.forename: P
authors.initials: P
authors.lastname: Kendall-Taylor
authors.forename: P
authors.initials: P
authors.lastname: Baylis
authors.forename: E
authors.initials: E
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Watson
authors.forename: D G
authors.initials: DG
authors.lastname: Johnston
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D013974:Thyroxine