[Perfluorocarbons do not induce cytochrome P-448 in the rat liver].
Cytochrome P-450 forms appearing in the liver after injection of methylcholanthrene, polychlorinated biphenyls and perfluorochemical emulsion to rats were studied. Activities of marker enzymes, benzpyrenehydroxylase and 7-ethoxyresorufin-O-deethylase, as well as the interaction of liver microsomal membranes with antibodies against different cytochrome forms were investigated. It was shown that fluorocarbon emulsion containing perfluorodecalin did not induce cytochrome P-448 in the rat liver.
Obraztsov
V V
VV
Shekhtman
D G
DG
Grishanova
A Iu
AIu
Mishin
V M
VM
D000818:Animals; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes / Q000096:biosynthesis*; D004790:Enzyme Induction; D005466:Fluorocarbons / Q000494:pharmacology*; D005779:Immunodiffusion; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D003580:Cytochromes; D005466:Fluorocarbons; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2
Perftororganicheskie soedineniia ne indutsiruiut obrazovaniia tsitokhroma P-448 v pecheni krys.