[Clinical analysis of 4 Chinese hemophiliacs with human immunodeficiency virus infection].
Human immunodeficiency virus (HIV-is) now considered the causative agent of acquired immunodeficiency syndrome(AIDS). A high risk of AIDS has been reported among patients with hemophilia who received lyophilized commercial factor VIII and IX concentrates of American origin. In a prevalence survey conducted from September to December 1985, HIV antibodies were found in all the 4 patients with hemophilia treated with the batch number W87307, 955 I.U. of American commercial factor VIII concentrate supplied by Armour pharmaceutical Company U.S.A. One of the seropositive patients developed AIDS-related complex (ARC) and died of cerebral hemorrhage. The other three sero-positive patients had abnormalities in cell mediated immunity; among them two developed left lumbosacral radiculopathy and hemorrhagic herpes zoster and one remains well so far.
Tang
D J
DJ
Xu
Y H
YH
Dai
D
D
D000386:AIDS-Related Complex / Q000209:etiology*; D000328:Adult; D002648:Child; D005164:Factor IX / Q000009:adverse effects* / Q000627:therapeutic use; D005169:Factor VIII / Q000009:adverse effects* / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000635:transmission*; D006467:Hemophilia A / Q000628:therapy*; D006562:Herpes Zoster / Q000209:etiology; D006801:Humans; D008297:Male; D011843:Radiculopathy / Q000209:etiology
D005169:Factor VIII; D005164:Factor IX