title: [Orthograde intestinal irrigation with a mannitol solution in reducing hepatic encephalopathy in patients with liver cirrhosis and gastrointestinal hemorrhage].
abstract: The development of hepatic encephalopathy and coma hepaticum in patients with acute gastrointestinal bleeding and hepatic cirrhosis is a serious problem. Since 1983 we perform a whole gut irrigation with mannite for cleansing the bowel via naso-gastric tube. The aim of this therapy is to reduce the severity of hepatic encephalopathy. The first 20 patients with the new therapeutic concept were compared with the last 20 patients with the prevailing therapy. We studied the effect of the new therapeutic concept as to reduction of hepatic encephalopathy and possible electrolyte loss. None of the patients in the mannite group had hepatic encephalopathy stage III or IV, whereas 75% of the patients without mannite showed clinical signs of stage III or IV. Serum potassium, sodium and chloride were not significantly different between both groups. In the group with mannite application no change in serum creatinine was observed, whereas in the other group a minute increase of serum creatinine was seen.
authors.affiliation: Bergmannsheil Bochum, Universitätsklinik, Abt. für Gastroenterologie und Hepatologie.
authors.forename: G H
authors.initials: GH
authors.lastname: Micklefield
authors.forename: U
authors.initials: U
authors.lastname: Schwegler
authors.forename: D
authors.initials: D
authors.lastname: Hüppe
authors.forename: H D
authors.initials: HD
authors.lastname: Kuntz
authors.forename: B
authors.initials: B
authors.lastname: May
mesh_terms: D000328:Adult; D005260:Female; D005751:Gastric Lavage / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006501:Hepatic Encephalopathy / Q000628:therapy*; D006801:Humans; D006982:Hypertonic Solutions; D007441:Intubation, Gastrointestinal; D008103:Liver Cirrhosis / Q000628:therapy*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D006982:Hypertonic Solutions; D008353:Mannitol
vernacular_title: Orthograde Darmspülung mit einer Mannitlösung zur Reduktion der hepatischen Enzephalopathie bei Leberzirrhotikern mit gastrointestinaler Blutung.