Early bronchopulmonary lesions in rat lung after normobaric 100% oxygen exposure and their evolution. A light and electron microscopic study.
In order to clarify the early phenomena involved in the lung reaction to hyperoxia, twenty adult male rats were exposed to 100% oxygen at 1 ATA. Morphological pulmonary lesions were detectable after only 24 h hyperoxia, and included vasoconstriction and perivascular oedema, bronchiolar constriction, and pericyte reaction. The lesions were irregularly scattered within the lung parenchyma and occurred preferentially in areas centred on bronchiolo-vascular stems. Even at the latest stages, pulmonary heterogeneity was obvious, from the coexistence of areas damaged at different times. Neuro-epithelial-bodies were found under the bronchiolar epithelium; the morphological aspect of the neuro-endocrine cells observed was consistent with hyperoxia-induced modulation of their secretory activity. Taken together, our findings show the speed of development of hyperoxia-induced pulmonary changes and raise some pathogenic considerations.
Porte
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Laboratoire de Physiologie, U.A. CNRS 309, Universite Louis Pasteur, Strasbourg, France.
Mantz
J
J
Hindelang
C
C
Asmarats
L
L
Viragh
S
S
Stoeckel
M E
ME
D000818:Animals; D001274:Atmospheric Pressure; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D001980:Bronchi / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010100:Oxygen / Q000009:adverse effects*; D011652:Pulmonary Circulation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014661:Vasoconstriction
D010100:Oxygen