title: Method for noninvasive determination of arterial PCO2 in anesthetized rats.
abstract: A method for the noninvasive determination of arterial PCO2 in mechanically ventilated rats is presented. In normotensive, rats under steady state conditions where a depth of anesthesia adequate to abolish spontaneous ventilatory effort was used, end-tidal CO2 and arterial PCO2 were highly correlated (r = 0.96; p less than 0.001). The regression equation for this relationship was: PaCO2 (mmHg) = 6.757 +/- 8.984 ETCO2(%). This method obviates the need for arterial cannulation and may be useful in neuropharmacological research in rats when knowledge of arterial CO2 alone is required.
authors.affiliation: Department of Anaesthesia, Vancouver General Hospital, B.C., Canada.
authors.forename: H
authors.initials: H
authors.lastname: Vaghadia
authors.forename: L C
authors.initials: LC
authors.lastname: Jenkins
authors.forename: R W
authors.initials: RW
authors.lastname: Ford
mesh_terms: D000758:Anesthesia; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012119:Respiration; D012121:Respiration, Artificial
chemical_list: D002245:Carbon Dioxide