title: Allergy to dialysis materials.
abstract: One hundred and six unselected patients were screened for allergic symptoms, specific IgE against ethylene oxide (ETO), isocyanates (ISO), formaldehyde (FA), phthalates (PHT), total IgE and eosinophil count. Complement activation was measured during cellulosic dialysis in atopic patients and in a control group. Sixteen patients demonstrated mild allergic symptoms during dialysis treatment. Ten of them had IgE elevation and eosinophilia. Eight of these patients had positive RASTs (ETO: n = 5, ETO-ISO(?)-FA: n = 2, ISO-PHT: n = 1) against dialysis material. All eight had an eosinophilia and seven showed an IgE elevation. An amelioration of symptoms could be obtained in three patients with elevated (greater than 15%) ETO-binding values after switching to ETO-free dialysers; avoiding PHT- and ISO-containing dialysis materials allergic symptoms remained constant. Cuprammonium rayon-induced complement activation had a more rapid onset and was more pronounced in atopic patients. The study confirms the role of ETO, but not of the other dialysis materials in the allergic sensitisation of haemodialysis patients.
authors.affiliation: Department of Nephrology, Deutsche Klinik für Diagnostik, Wiesbaden, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Röckel
authors.forename: B
authors.initials: B
authors.lastname: Klinke
authors.forename: J
authors.initials: J
authors.lastname: Hertel
authors.forename: X
authors.initials: X
authors.lastname: Baur
authors.forename: C
authors.initials: C
authors.lastname: Thiel
authors.forename: S
authors.initials: S
authors.lastname: Abdelhamid
authors.forename: P
authors.initials: P
authors.lastname: Fiegel
authors.forename: D
authors.initials: D
authors.lastname: Walb
mesh_terms: D003167:Complement Activation; D003485:Cyanates / Q000009:adverse effects / Q000276:immunology; D004802:Eosinophilia / Q000209:etiology; D005027:Ethylene Oxide / Q000009:adverse effects / Q000276:immunology; D005557:Formaldehyde / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D006969:Hypersensitivity, Immediate / Q000209:etiology; D007073:Immunoglobulin E / Q000378:metabolism; D007688:Kidneys, Artificial / Q000009:adverse effects*; D010795:Phthalic Acids / Q000009:adverse effects / Q000276:immunology; D011852:Radioallergosorbent Test
chemical_list: D003485:Cyanates; D010795:Phthalic Acids; D005557:Formaldehyde; D007073:Immunoglobulin E; C032279:phthalic acid; D005027:Ethylene Oxide; C005057:isocyanic acid