Radiation enhancement of lung nodule formation in mice is not potentiated by treatment with a perfluorochemical emulsion and carbogen.
The ability of intravenously-injected mouse mammary tumor cells to form lung tumors is increased by irradiation of the thorax 24 h previously. We examined the effects of treatment with a perfluorochemical emulsion (Fluosol-DA, 20%) plus carbogen before and during irradiation on the radiation-induced enhancement of lung nodule formation. We found no evidence that treatment with Fluosol plus carbogen altered the development of tumor nodules in irradiated mouse lungs.
Rockwell
S
S
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510-8040.
Kelley
M
M
D000818:Animals; D002245:Carbon Dioxide / Q000633:toxicity*; D004338:Drug Combinations / Q000633:toxicity; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D006895:Hydroxyethyl Starch Derivatives; D008175:Lung Neoplasms / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced; D011829:Radiation Dosage
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D002245:Carbon Dioxide; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination