title: Expression of HLA-DR antigen in epiretinal and vitreous membranes.
abstract: The pathogenic mechanisms of epiretinal membranes are not clearly understood nowadays in ophthalmology. Trying to elucidate it from another aspect, we examined the presence of HLA-DR antigen in 41 epiretinal membrane specimens from patients with proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR) by using immunohistochemical technique (APAAP). The results showed that 82.93% of the membranes (34 out of 41) were HLA-DR antigen positive. HLA-DR antigen was considered to be expressed by macrophages in epiretinal membranes. The findings here reveal that the formation and development of epiretinal membranes are probably correlated with immune responses.
authors.forename: S B
authors.initials: SB
authors.lastname: Tang
authors.forename: O F
authors.initials: OF
authors.lastname: Scheiffarth
mesh_terms: D003930:Diabetic Retinopathy / Q000276:immunology; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D008566:Membranes / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D012160:Retina / Q000276:immunology*; D012164:Retinal Diseases / Q000276:immunology*; D014822:Vitreous Body / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens