[Adaptation of the body to alkylating anti-tumor substances].
It is determined that the organism may adapt in principle to alkylating antitumour preparations, to thiophosphamide in particular, being administered for a long time. The development of cell adaptation reactions in the systems of hemopoiesis and microsomal oxidation of hepatocytes is studied. An increase in the activity of enzymes of the microsomal liver oxidation system is found as accompanied by a lower concentration of 35S-thiophosphamide in the studied tissues and blood serum. The reactivity of tissue and serum SH-groups is observed to decrease with the organism adaptation to the preparation.
Kulik
G I
GI
Pel'kis
F P
FP
Korol'
V I
VI
D000220:Adaptation, Biological; D000477:Alkylating Agents / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents; D004351:Drug Resistance; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D051381:Rats; D013438:Sulfhydryl Compounds / Q000097:blood; D013852:Thiotepa / Q000493:pharmacokinetics / Q000627:therapeutic use
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D013438:Sulfhydryl Compounds; D013852:Thiotepa
Adaptatsiia organizma k alkiliruiushchim protivoopukholevym preparatam.