title: [Treatment of stage I malignant melanoma].
abstract: In 259 patients with malignant melanoma of the skin referred here during 1973-1984, the median follow-up was 46 months. Of 182 with stage I disease, 97 (53.2%) were women and 85 men. Of these, 90.1% were Jews of European extraction and 8.2% were Jews of Asian-African extraction, while only 1.8% were non-Jews. 171 (94%) of the patients were treated by wide excision, with or without skin graft, as primary treatment, while 11 had limited local excision. In 16.4% the primary tumor was located on the upper limbs, in 34.6% the lower limbs, in 27.5% the trunk and in 19.2% the head and neck. 5-year survival was 70%. The 5-year actuarial survival was significantly influenced by: age (those under 50 had better survival, 79.5% vs 58.4%, p less than 0.05); by site of the primary lesion (88.5% for those of the upper limbs vs 59.4% for those of the lower limbs), p less than 0.01]; by depth of invasion as seen microscopically (81.2% for Clark I-II vs 52.8% for Clark IV-V, p less than 0.02); and by site of recurrence (43.4% if local vs 0 for distant, p less than 0.02).
authors.affiliation: Northern Israel Oncology Center, Rambam Medical Center, Haifa.
authors.forename: G
authors.initials: G
authors.lastname: Fried
authors.forename: M
authors.initials: M
authors.lastname: Stein
authors.forename: R
authors.initials: R
authors.lastname: Borovik
authors.forename: M
authors.initials: M
authors.lastname: Ben Shachar
authors.forename: E
authors.initials: E
authors.lastname: Robinson
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016038:Skin Transplantation; D015996:Survival Rate