[Effect of stress and the adaptogen cucurbitacin R diglycoside on arachidonic acid metabolism].
Rat leukocytic lipoxygenase activity is decreased in stress. The production of 12-hydroxy-5z, 8z, 10E-heptadecatrienic acid (12-HHT) (the product of cyclooxygenase metabolism of arachidonic acid-AA) is increased. Cucurbitacin R diglucoside (CRD), an adaptogen, raising working capacity and corticosteroid secretion, produces a similar effect on leukocytes. Preliminary injection of CRD to animals prevents changes caused by stress, which indicates a CRD adaptogenic effect on the body.
Panosian
A G
AG
Dadaian
M A
MA
Gevorkian
G A
GA
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D004789:Enzyme Activation; D015289:Leukotrienes / Q000096:biosynthesis; D008084:Lipoxygenase / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D014315:Triterpenes / Q000494:pharmacology*
D001095:Arachidonic Acids; D015289:Leukotrienes; D014315:Triterpenes; C054202:cucurbitacin R 2,25-diglucoside; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases
Vliianie stressa i adaptogena digliukozida kukurbitatsina R na prevrashchenie arakhidonovoĭ kisloty.