Resistance of Mycobacterium avium to microbicidal activities in bone-marrow macrophages from naturally-susceptible (C57B1/6) and naturally-resistant (DBA-2) mice.
In this study, the phagosome-lysosome fusion (PLF) inhibition and the presence of the electron-transparent zone (ETZ) around phagocytized Mycobacterium avium both in the naturally-susceptible and naturally-resistant mice was compared. We observed marked differences in case of these two mice strains, as PLF inhibition, as well as the presence of ETZ, was more important in case of naturally-susceptible mice.
Rastogi
N
N
Unité Tuberculose et Mycobactéries, Institut Pasteur, Paris, France.
Fréhel
C
C
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D005260:Female; D066298:In Vitro Techniques; D008247:Lysosomes / Q000648:ultrastructure; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D008561:Membrane Fusion; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009162:Mycobacterium avium / Q000276:immunology* / Q000472:pathogenicity; D010588:Phagosomes / Q000648:ultrastructure; D013045:Species Specificity