Chronic neutrophilic leukemia with dysplastic features. A new variant of the myelodysplastic syndromes.
We are reporting four patients who presented with a persistent increase of mature neutrophils and band forms, no monocytosis in repeated examinations and with dysplastic features in blood and bone marrow. Two of them developed acute myeloid leukemia (AML; FAB classification M1) and the other two were characterised by a progressively aggravating myelodysplasia. All the patients showed a poor response to treatment and died within a period of time ranging from 14 to 80 months after diagnosis. We are proposing the term chronic neutrophilic leukemia with dysplastic features (CNL-D) for this entity, and we believe that it represents a variant of the myelodysplastic syndromes.
Zoumbos
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NC
Department of Internal Medicine, Patras University Medical School, Greece.
Symeonidis
A
A
Kourakli-Symeonidis
A
A
D000368:Aged; D005260:Female; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000145:classification* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification*