Immunohistochemical characterization of spontaneous amyloidosis in captive birds as AA-type, using monoclonal and polyclonal anti-AA antibodies against mammalian amyloid.
Spontaneous amyloid diagnosed by means of Congo red and polarization microscopy in 3 flamingos, 1 crowned crane, 1 red-breasted goose, and 1 common golden-eye was studied using immunohistochemical techniques. The avian amyloid cross-reacted with a number of monoclonal and polyclonal anti-AA antibodies directed against mammalian amyloid fibril proteins. This confirmed that both "secondary" and "idiopathic" avian amyloid is of the AA-type. The results demonstrate the possibility to successfully using cross-reactive anti-AA antibodies for the diagnosis of non-mammalian amyloidosis.
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Forschungsstelle für Wirbeltierforschung, Akademie der Wissenschaften der DDR, Berlin.
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D000686:Amyloidosis / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001715:Bird Diseases / Q000378:metabolism*; D001717:Birds; D005260:Female; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D000685:Serum Amyloid A Protein / Q000032:analysis*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000685:Serum Amyloid A Protein