The association between apolipoprotein A-I and prostacyclin binding in human serum.
The stability of Prostacyclin in human blood is dependent upon binding to circulating proteins. Although this binding has been considered to be primarily due to albumin, a recent report has suggested that apolipoprotein A-I is responsible. We compared prostacyclin binding to the concentration of albumin and apolipoprotein A-I in several groups of sera with known differences in the ability to bind prostacyclin. Our results indicate a strong correlation with albumin concentration but no correlation between binding and the concentration of apolipoprotein A-I. It appears that in the human circulation albumin concentration is the most important determinant of prostacyclin binding.
O'Brien
W F
WF
Dept. of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33612.
Torres
C
C
Benoit
R
R
Knuppel
R A
RA
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D012709:Serum Albumin; D011464:Epoprostenol