[Relationship of eicosanoids to cellular and humoral immunity factors in meningococcal infection].
The dynamics of the content of thromboxane B2, 6-keto-prostaglandin F1 alpha, T- and B-lymphocytes and titers of antibodies to group polysaccharides of meningococci, groups A, B and C, have been studied in 44 patients with generalized forms of meningococcal infection. As shown in this study, in patients with the clinical course of moderate severity a decrease in the number of T-lymphocytes in the first days of infection correlates with a decrease in the concentration of thromboxane B2. In some cases the concentration of thromboxane B2 and 6-keto-prostaglandin F1 alpha has been found to correlate with the titers of antibodies to group polysaccharide of group A meningococci. The severe course of meningococcal infection is characterized by the absence of correlation between eicosanoids and the immunity factors under study.
Pokrovskiĭ
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VI
Rezhabek
A E
AE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008585:Meningitis, Meningococcal / Q000097:blood / Q000276:immunology; D008589:Meningococcal Infections / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000276:immunology; D011134:Polysaccharides / Q000276:immunology; D011453:Prostaglandins / Q000097:blood*; D018805:Sepsis / Q000097:blood / Q000276:immunology; D013931:Thromboxanes / Q000097:blood*; D013997:Time Factors
D000907:Antibodies, Bacterial; D011134:Polysaccharides; D011453:Prostaglandins; D013931:Thromboxanes
Sviaz' éĭkozanoidov s nekotorymi faktorami kletochnogo i gumoral'nogo immuniteta pri meningokokkovoĭ infektsii.