[Biochemical diagnoses of malignant melanomas with determinations of 5-S-cysteinyldopa in lesions].
To develop a biochemical diagnosis for malignant melanomas, 5-S-cysteinyldopa in the tissues of malignant melanomas and other pigmented tumors were quantitatively analysed. The mean 5-S-CD value from primary melanotic melanoma lesions was 202.4 ng/mg (80.6-821.4) and those of metastatic melanoma lesions was 214.0 ng/mg (96.2-520.0). There was no significant differences in these 5-S-CD values between the types of primary lesions. On the other hand, the 5-S-CD values from pigmented tumors other than melanomas, such as Spitz nevus, dysplastic nevus, pigmented basal cell epithelioma, and melanoepithelioma Bloch II were less than 55 ng/mg. From these results it is thought that pigmented tumors can be diagnosed as malignant melanomas, if the 5-S-CD values in the tissues are over 100 ng/mg. The mean 5-S-CD values of pigmented macules of SSM was 734.5 ng/mg (320.0-1666.3) and those of ALM was 1.8 ng/mg (0.7-3.6). These data suggest that the biochemical diagnoses of SSM in situ can be based on 5-S-CD values, the diagnoses of ALM in situ can not.
Sameshima
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Morishima
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D003548:Cysteinyldopa / Q000032:analysis*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000032:analysis / Q000175:diagnosis*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000032:analysis / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine