A perspective of psoriasis as an aberration in skin modified to expression by the inflammatory/repair system.
Evidence has been presented which shows that psoriasis is a disease with inherent aberrations in the skin. The consistently observed aberration in skin is excess proliferation of cellular constituents, particularly the epidermis. This occurs independent of overt inflammatory/repair processes. Evidence is presented to suggest that regulatory factors are present in this disease and affect disease expression on a bodywide basis, and therefore would appear to be circulating. Further, without inflammatory/repair processes possibly unique to patients with psoriasis, clinical lesions of psoriasis are not present and the multitude of abnormalities reported to be present in the inflammatory/repair system are secondary. Finally, the thesis is proposed that in psoriasis, the increased cell turnover status of skin is proinflammatory; the body attempts to regulate this, usually without total success; and the chronic attempts to regulate the disease are frequently broached by exogenous factors.
Krueger
G G
GG
University of Utah School of Medicine, Salt Lake City.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D015535:Arthritis, Psoriatic / Q000503:physiopathology; D002455:Cell Division; D006801:Humans; D007239:Infections / Q000150:complications; D007249:Inflammation; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D011565:Psoriasis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000293:injuries / Q000473:pathology*; D016038:Skin Transplantation / Q000473:pathology; D014183:Transplantation, Heterologous
D000276:Adjuvants, Immunologic