title: Effect of a mammary-derived growth inhibitor on the expression of the oncogenes c-fos, c-myc and c-ras.
abstract: A mammary-derived growth inhibitor (MDGI) inhibits the resumption of growth of stationary Ehrlich ascites carcinoma (EAC) cells in vitro. The present study shows that the resumption of growth is accompanied by a rapid increase of the steady state mRNA level of the proto-oncogenes c-fos, c-myc and c-ras, which is reduced by MDGI. EAC cells from the exponential growth phase insensitive to MDGI did not show a reduced RNA expression. The effect of MDGI represents a novel activity at the level of gene expression and suggests a link to exist between growth inhibition and the reduction of c-fos, c-myc and c-ras expression.
authors.affiliation: Central Institute for Molecular Biology, Academy of Sciences, Berlin-Buch, GDR.
authors.forename: W
authors.initials: W
authors.lastname: Lehmann
authors.forename: M
authors.initials: M
authors.lastname: Strauss
authors.forename: U
authors.initials: U
authors.lastname: Kiessling
authors.forename: H
authors.initials: H
authors.lastname: Graetz
authors.forename: A
authors.initials: A
authors.lastname: Koberling
authors.forename: P
authors.initials: P
authors.lastname: Langen
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D002455:Cell Division; D005786:Gene Expression Regulation; D006131:Growth Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000032:analysis*; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D016283:Proto-Oncogene Proteins p21(ras); D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D006131:Growth Inhibitors; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D016283:Proto-Oncogene Proteins p21(ras)