title: Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis.
abstract: Humoral immunity was evaluated in seven children undergoing continuous ambulatory peritoneal dialysis (CAPD). Five children (71%) had serum immunoglobulin levels which were more than 2 SD below the mean for age. One mechanism contributing to hypogammaglobulinemia was loss via the peritoneal membrane. Daily losses of IgG into peritoneal dialysis effluents represented 7%-29% of normal daily IgG synthesis, and losses increased with duration of CAPD therapy. Despite the observed hypogammaglobulinemia, all children had protective antibody responses to immunization.
authors.affiliation: Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: B A
authors.initials: BA
authors.lastname: Fivush
authors.forename: B
authors.initials: B
authors.lastname: Case
authors.forename: M W
authors.initials: MW
authors.lastname: May
authors.forename: H M
authors.initials: HM
authors.lastname: Lederman
mesh_terms: D001826:Body Fluids / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010529:Peritoneal Cavity; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D005719:gamma-Globulins / Q000032:analysis*
chemical_list: D007136:Immunoglobulins; D005719:gamma-Globulins