NF-kappa B binds within a region required for B-cell-specific expression of major histocompatibility complex class II gene E alpha d.
A region upstream of the murine major histocompatibility complex gene, E alpha d, has been shown previously to be required for B-cell expression. Binding of the B-cell-specific factor, NF-kappa B, to a site within this region is indistinguishable from that observed with the kappa enhancer binding site. NF-kappa B may be responsible for E alpha d B-cell expression.
Blanar
M A
MA
Biogen Research Corporation, Cambridge, Massachusetts 02142.
Burkly
L C
LC
Flavell
R A
RA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005802:Genes, MHC Class II; D051379:Mice; D016328:NF-kappa B; D015183:Restriction Mapping; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D016328:NF-kappa B; D014157:Transcription Factors; D004247:DNA