Influence of various concentrations of cefotiam and ceftizoxime on the phagocytosis of gonococci by polymorphonuclear granulocytes.
Both cefotiam and ceftizoxime stimulate the uptake of gonococci by polymorphonuclear granulocytes in vitro as can be seen by light microscopy. Although this already holds true of antibiotic concentrations lower than the minimum inhibitory concentration (MIC: 1/4 x) this effect is much more marked at concentrations highly exceeding the MIC (4000 x). As light microscopic investigation allows the analysis of large numbers of cells but no final judgement on actual bacterial engulfment definite phagocytosis is demonstrated by electron microscopy.
Korting
H C
HC
Department of Dermatology, Ludwig-Maximilians-University, Munich, Fed. Rep. of Germany.
Seitz
R
R
Kreller
W
W
D015310:Cefotiam / Q000494:pharmacology*; D015296:Ceftizoxime / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*
D015310:Cefotiam; D015296:Ceftizoxime