Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis.
The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA). The first carcinoma was detected after only 1 month of DMBA applications. After a further 8 months 85% of the animals had developed one or more squamous cell carcinomas. The latency period for DMBA-induced oral cancer in cirrhotic rats with xerostomia was markedly reduced in comparison with previous findings from xerostomic rats without liver cirrhosis. The results support earlier epidemiologic studies indicating a relationship between liver cirrhosis and oral cancer.
Lekholm
U
U
Brånemark Clinic, Public Dental Health Service of Gothenburg, Sweden.
Stenman
G
G
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002251:Carbon Tetrachloride; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D005260:Female; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012602:Scopolamine Derivatives; D013997:Time Factors; D014987:Xerostomia / Q000139:chemically induced / Q000150:complications*
D012602:Scopolamine Derivatives; D015127:9,10-Dimethyl-1,2-benzanthracene; D002251:Carbon Tetrachloride