Double-blind evaluation of the effect of acute amantadine on cocaine craving.
Single doses of amantadine hydrochloride and placebo were administered in a double-blind cross-over design on separate days to ten actively craving cocaine abusers in treatment. Pharmacological treatment did influence cocaine craving, but amantadine was less effective than placebo.
Gawin
F H
FH
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.
Morgan
C
C
Kosten
T R
TR
Kleber
H D
HD
D000547:Amantadine / Q000627:therapeutic use*; D003042:Cocaine / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000523:psychology
D000547:Amantadine; D003042:Cocaine