title: Scrapie agent decontamination: implications for bovine spongiform encephalopathy.
abstract: Bovine spongiform encephalopathy probably results from the use of commercial diets containing scrapie-contaminated ingredients. Of all the chemical and physical decontamination procedures which are effective against conventional viruses, only high temperature autoclaving, high concentrations of sodium hypochlorite, and possibly molar sodium hydroxide, are useful against the group of unconventional transmissible agents which includes scrapie. The implications of this problem for the rendering industry and farm practice are discussed.
authors.affiliation: Neuropathogenesis Unit, Institute for Animal Health, Edinburgh.
authors.forename: D M
authors.initials: DM
authors.lastname: Taylor
mesh_terms: D000821:Animal Feed; D000818:Animals; D001688:Biological Products; D001842:Bone and Bones; D001927:Brain Diseases / Q000209:etiology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D004203:Disinfection; D005516:Food Microbiology; D006358:Hot Temperature; D008460:Meat; D008903:Minerals; D011328:Prions / Q000502:physiology*; D012756:Sheep; D012972:Sodium Hydroxide; D012973:Sodium Hypochlorite
chemical_list: D001688:Biological Products; D008903:Minerals; D011328:Prions; D012972:Sodium Hydroxide; D012973:Sodium Hypochlorite; C027762:bone meal