Enucleation after intraocular scrapie injection delays the spread of infection.
After right intraocular infection, mice develop lesions in the contralateral retinal projections long before clinical disease occurs. Enucleation up to 7 days post-infection prevented targeting of lesions to visual projections, and prolonged the incubation period. When enucleation was delayed until at least 14 days post-infection, lesion targeting and incubation periods were similar to unenucleated mice. It was concluded that infectivity took a minimum of 14 days to reach the brain via the optic nerve.
Scott
J R
JR
AFRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, U.K.
Fraser
H
H
D000818:Animals; D005123:Eye / Q000382:microbiology*; D007267:Injections; D051379:Mice; D013508:Ophthalmologic Surgical Procedures; D011328:Prions / Q000472:pathogenicity*; D012608:Scrapie / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D013477:Superior Colliculi / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors
D011328:Prions