Comparative studies of doxorubicin and 4'-epidoxorubicin effects on cardiovascular system in rabbits.
4'-epidoxorubicin (4'-epiDXR) was compared with doxorubicin (DXR) for myocardial effects in rabbits. Histologically, both drugs when given for six weeks induced a high incidence of diffused myocardial damage. The myocardial damage was less evident in rabbits treated with 4'-epiDXR than DXR for 3 weeks. Functionally 4'-epiDXR like DXR significantly reduced cardiac index (CI), stroke index (SI) and mean arterial blood pressure (MAP).
Fronczak
A
A
Laboratory of Clinical Pharmacology, Medical Academy, Lódź, Poland.
Drzewoski
J
J
Polakowski
P
P
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003892:Deslanoside / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D015251:Epirubicin / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D013318:Stroke Volume / Q000187:drug effects
D015251:Epirubicin; D004317:Doxorubicin; D003892:Deslanoside