Short-term parenteral nutrition with glucose and Intralipid: effects on serum lipids and lipoproteins.
We prospectively investigated the effect of a 3-wk course of parenteral nutrition with 20% glucose, 4.25% amino acids, and 10% Intralipid on plasma lipids and lipoproteins in a cohort of 12 nutritionally replete patients with inflammatory bowel disease. Mean total serum cholesterol and mean total serum phospholipids increased in parallel throughout the study; density gradient ultracentrifugation demonstrated these increases were due to the appearance of lipoprotein-X. The mean low-density lipoprotein (LDL) mass on the density gradients decreased during the study and high-density lipoprotein (HDL) cholesterol levels decreased by 28% by the end of the third week. Plasma free fatty acids decreased by 42%. These results demonstrate that the glucose and 10% Intralipid regimen caused modest decreases in serum HDL cholesterol and LDL mass and the prompt appearance of lipoprotein-X with attendant hypercholesterolemia and hyperphospholipidemia. Patients undergoing long-term treatment with glucose and Intralipid should be closely monitored for the occurrence of significant dyslipoproteinemia.
Weinberg
R B
RB
Department of Medicine, University of Texas Health Science Center, Houston 77225.
Singh
K K
KK
D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008073:Lipoprotein-X / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D013997:Time Factors; D014280:Triglycerides / Q000096:biosynthesis
D008078:Cholesterol, LDL; D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008073:Lipoprotein-X; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D005947:Glucose