Isolation and study of two mutants of Streptomyces cattleya affected in DNA repair and genetic instability.
Two mutants of Streptomyces cattleya affecting DNA repair were isolated. These mutants were analysed using spore survival curves and phage reactivation curves in the presence and absence of caffeine and arsenite. Two DNA repair systems (uvr1 and uvr2) were identified, the latter of which seems to influence genetic instability.
Hromic
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A
Department of Microbiology, University of Stellenbosch, South Africa.
Kirby
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R
D001151:Arsenic / Q000494:pharmacology; D018053:Arsenites; D002110:Caffeine / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005798:Genes, Bacterial / Q000187:drug effects / Q000528:radiation effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D013171:Spores, Bacterial / Q000528:radiation effects; D013291:Streptococcus / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays
D018053:Arsenites; D008937:Mitomycins; D002110:Caffeine; D016685:Mitomycin; C015001:arsenite; D001151:Arsenic