Acute nonlymphocytic leukemia: evidence of clonogenic cells in peripheral blood in early complete remission.
We describe a patient with acute nonlymphocytic leukemia in whom chromosomal analysis showed a 8,21(q22;q22) translocation and who entered complete remission after one course of chemotherapy. During the post-chemotherapy aplastic phase blood-derived hemopoietic circulating stem cells were collected by continuous flow aphereses. Chromosomal analysis on the collected cells and on colonies (CFU-GM grown in agar) showed the same anomaly as was present at diagnosis in about 30% of those analyzed. This confirms the persistence of the malignant clone in the early phase of the clinical remission in acute nonlymphocytic leukemia.
Castagnola
C
C
Division of Hematology, IRCCS Policlinico S. Matteo, Pavia, Italy.
Bonfichi
M
M
Colombo
A
A
Bernasconi
P
P
Bernasconi
C
C
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D007937:Leukapheresis; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D012074:Remission Induction; D014178:Translocation, Genetic / Q000235:genetics
D003561:Cytarabine; D003630:Daunorubicin