Cr-ethylenediaminetetraacetic acid absorption test. Methodologic aspects.
The 51Cr-ethylenediaminetetraacetic acid (EDTA) absorption test was evaluated in 83 healthy, male volunteers. Base-line 24-h excretion after peroral administration ranged from 0.88% to 7.96%, with a higher median absorption than reported by most authors (2.45%). However, the reproducibility and stability of the method and the reproducibility of the results were satisfactory. Urinary excretion after intraduodenal instillation (n = 18) was comparable to that seen after peroral test dose administration, indicating a limited significance of gastric 51Cr-EDTA absorption under normal conditions. In 16 subjects a single intake of alcohol immediately before the test gave a modest and short-lasting increase in 51Cr-EDTA absorption. No correlation was seen to body mass index, creatinine clearance, urinary volume, or small-bowel transit time, possibly reducing the number of confounding factors in the evaluation of absorption data. A small but significant negative correlation was, however, found to body surface area and age.
Aabakken
L
L
Medical Dept., Ullevål Hospital, Oslo, Norway.
D000293:Adolescent; D000328:Adult; D001830:Body Surface Area; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000493:pharmacokinetics; D004386:Duodenum / Q000378:metabolism; D004492:Edetic Acid / Q000493:pharmacokinetics*; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male
D002860:Chromium Radioisotopes; D000431:Ethanol; D004492:Edetic Acid; D003404:Creatinine