Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor alpha.
Recombinant human tumor necrosis factor alpha (rHuTNF-alpha) administered intravenously to mice resulted in enhanced resistance to a lethal challenge infection of Listeria monocytogenes given 24 h later. The observed protection was lost following treatment of the rHuTNF-alpha preparations with rabbit polyclonal antibody rHuTNF-alpha but not with normal rabbit immunoglobulin G.
Desiderio
J V
JV
Department of Microbiology, Bristol-Myers Co., Wallingford, Connecticut 06492.
Kiener
P A
PA
Lin
P F
PF
Warr
G A
GA
D000818:Animals; D000937:Antigen-Antibody Reactions; D008070:Lipopolysaccharides / Q000494:pharmacology; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D011994:Recombinant Proteins / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000627:therapeutic use*
D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha