title: Opposite effect of donor-specific immunization by blood or splenocytes on the survival of heart tissue transplants in strong versus weak histoincompatible combination in mice.
abstract: Recipients of allogeneic heart tissue were pretreated intravenously with blood or injected intraperitoneally with spleen cells. In H-2 incompatible donor-recipient combination (BALB/c----CBA/H) donor-specific immunization, both with blood and spleen cells, resulted in acceleration of graft rejection. On the other hand, increase in graft survival was observed following donor-specific but not third-party blood pretreatment in mice compatible in H-2 complex but bearing different minor histoincompatible antigens (BALB/c----DBA/2).
authors.affiliation: Department of Transplantology, Institute of Biostructure, Medical School, Warsaw.
authors.forename: W
authors.initials: W
authors.lastname: Lasek
authors.forename: M
authors.initials: M
authors.lastname: Jakóbisiak
authors.forename: M
authors.initials: M
authors.lastname: Grochowska
authors.forename: M
authors.initials: M
authors.lastname: Płodziszewska
authors.forename: D
authors.initials: D
authors.lastname: Górecki
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006183:H-2 Antigens; D016027:Heart Transplantation / Q000276:immunology*; D006648:Histocompatibility; D007114:Immunization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
chemical_list: D006183:H-2 Antigens