Side-effects and immunogenicity of Haemophilus influenzae type B polysaccharide vaccine in a multiethnic pediatric population.
Side-effects and immunogenicity of the Haemophilus influenzae type B polysaccharide vaccine (Hbpv) were reported following introduction in a multi-ethnic border population of 2- to 6-year-old U.S. military dependents. Eighty percent of 659 vaccinees were reported by parents to have no reactions within 48 hours following vaccination; 20% were reported to have local and/or systemic reactions. Each reaction was reported with one-fifth or less the frequency previously reported following DPT vaccination. Serologic data are presented on 114 of the vaccinees. The frequency of pre-vaccination levels reportedly associated with immunity ranged from a lower than expected 54% of 2-year-olds to an expected 86% of 5-year-olds. Post-vaccination levels reportedly associated with immunity ranged from a lower than expected 80% of 2-year-olds to an expected 93% of 5-year-olds. Of the 114 vaccines with serologic data, those with side-effects had serologic changes comparable to those without side-effects. There was no difference in side-effects or immunologic response across ethnic groups. Therefore, side-effects, immunologic responses, and ethnic group appear to be independent variables.
Popejoy
L A
LA
Rivera
A I
AI
Gonzales-Torres
I
I
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001428:Bacterial Vaccines / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D044383:Black People; D002648:Child; D002675:Child, Preschool; D006193:Haemophilus influenzae / Q000276:immunology*; D006630:Hispanic or Latino; D006801:Humans; D008889:Military Personnel
D000888:Antibodies, Anti-Idiotypic; D001428:Bacterial Vaccines