[Inhibitory effects of secretio bufonis on carcinogenesis of the rat trachea with chick embryonic skin in culture].
The present investigation evaluated the inhibitory effects of Secretio Bufonis on the carcinogenesis of rat trachea contacted with chick embryonic skin (CES) in culture under inverted microscopy, light microscopy and scanning electron microscopy. The experimental results showed that the malignant cells of tracheal rings revealed an invasion into the CES in the group M but the group N and group S did not. It suggested that Secretio Bufonis might inhibit the carcinogenesis induced by MCA, reverse the atypical squamous metaplasia, promote the repair of tracheal mucosa and maintain normal differentiation of the rat tracheal epithelia. In addition, group M indicated the hyperplasia and metaplasia of some ciliated cells exposed to MCA. The mechanism of Secretio Bufonis against lung cancer and the possibility of canceration of ciliated cells have been discussed.
Zhu
Y M
YM
Tian
H S
HS
D000664:Amphibian Venoms / Q000494:pharmacology*; D000818:Animals; D002023:Bufo bufo; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002642:Chick Embryo; D046508:Culture Techniques; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000166:cytology*; D014132:Trachea / Q000166:cytology*
D000664:Amphibian Venoms