Modification of the mutagenicity of aflatoxin B1 and N-methyl-N'-nitro-N-nitrosoguanidine by certain phenolic compounds.
Five natural and two synthetic phenolic compounds were tested for their ability to suppress mutagenicity of aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium tester strain TA100. Caffeic acid and eugenol were observed to inhibit mutagenicity of both the carcinogens, while chlorogenic acid was effective in the case of AFB1 alone and ellagic acid and butylated hydroxytoluene were found to be antimutagenic only for MNNG. These differential activities of the phenolic compounds appeared to be due to their different modes of action towards direct and indirect acting carcinogens.
Francis
A R
AR
Biochemistry Division, Bhabha Atomic Research Centre, Bambay, India.
Shetty
T K
TK
Bhattacharya
R K
RK
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D002109:Caffeic Acids / Q000494:pharmacology; D004347:Drug Interactions; D005054:Eugenol / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D010636:Phenols / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D000348:Aflatoxins; D002109:Caffeic Acids; D009153:Mutagens; D010636:Phenols; D008769:Methylnitronitrosoguanidine; D005054:Eugenol; D016604:Aflatoxin B1