Altered electrical responses of B-cells after goldthioglucose-induced lesions in the ventromedial hypothalamus.
Goldthioglucose was used to induce necrosis of the ventromedial hypothalamus in mice. This produced an obese mouse that exhibited syndromes associated with non-insulin dependent diabetes mellitus (NIDDM). We found enhanced glucose-induced electrical activity from B-cells with impaired neurotransmitter input. This information indicates that the electrical events of the B-cell plasma membrane are influenced by altered neurotransmitter input and may play a causal role in the enhanced secretory response.
Pace
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C
Department of Physiology & Biophysics, University of Alabama, Birmingham 35294.
Delmo
C
C
Lee
R
R
D000818:Animals; D006051:Aurothioglucose / Q000633:toxicity*; D004594:Electrophysiology; D005947:Glucose / Q000494:pharmacology; D006046:Gold / Q000633:toxicity*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008820:Mice, Obese; D008839:Microelectrodes; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects*
D006051:Aurothioglucose; D006046:Gold; D005947:Glucose