Exposure of newborn mice to adenosine causes neural crest dysplasia and tumor formation.
In the first part of this paper, we show that intraperitoneal injection of adenosine into newborn mice causes multiple neural crest tumors, neural crest hyperplasia, and heterotopic melanin pigmentation. In the second part, we review published data to propose (1) that microtubule proteins, phosphorylated through the action of calmodulin-dependent kinase and cyclic adenosine monophosphate and the adenosine A2 receptor of neural crest cells, may participate in neurotransmission and (2) that at least some neural crest tumors may be associated with disorders of neurotransmission in embryonic neural crest cells.
Nozue
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Department of Anatomy, Tokyo Medical and Dental University, Japan.
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D000241:Adenosine; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D001859:Bone Neoplasms / Q000139:chemically induced / Q000473:pathology; D002345:Carotid Body Tumor / Q000139:chemically induced / Q000473:pathology; D004067:Digestive System Neoplasms / Q000139:chemically induced / Q000473:pathology; D008543:Melanins / Q000378:metabolism; D008545:Melanoma / Q000139:chemically induced / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000473:pathology; D009432:Neural Crest / Q000473:pathology*; D009455:Neurofibroma / Q000139:chemically induced / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced / Q000473:pathology; D010673:Pheochromocytoma / Q000139:chemically induced / Q000473:pathology; D010859:Pigmentation Disorders / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology; D014062:Tongue Neoplasms / Q000139:chemically induced / Q000473:pathology
D008543:Melanins; D000241:Adenosine