The effects of norepinephrine depletion on cerebral blood flow in the rat.
Cerebral blood flow (CBF) was measured by [14C]butanol indicator fractionation in 10 rats given intraventricular injections of 6-hydroxydopamine (6-OHDA) compared to 8 saline-injected controls. Rats treated with 6-OHDA displayed an 83% reduction in cortical norepinephrine (NE) levels. CBF was significantly increased in 6-OHDA-treated rats compared to controls (average whole brain blood flow of 126.0 +/- 8.3 and 97.1 +/- 10.6 ml.min-1.10(-2)g-1 respectively, P less than 0.05). These studies suggest that noradrenergic innervation of the brain and cerebral microvasculature exerts a moderating effect on resting CBF.
Onesti
S T
ST
Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, NY.
Strauss
R C
RC
Mayol
B
B
Solomon
R A
RA
D000818:Animals; D000440:Butanols / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004298:Dopamine / Q000502:physiology*; D007839:Functional Laterality; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000440:Butanols; D006892:Hydroxydopamines; D016627:Oxidopamine; D010293:Pargyline; D004298:Dopamine; D009638:Norepinephrine