title: Characterization of CNS lesions by using high-resolution 1H MR spectroscopy of CSF: preliminary results.
abstract: Sixty-six samples of CSF from 66 patients with a variety of diseases, including tumors, arteriovenous malformations, aneurysms, brain infarctions, and lumbar back pain, were studied with 1H MR spectroscopy at 360 MHz. 1H MR spectroscopy offers a simple means to obtain fast information about different metabolites simultaneously. As compared with the control group, which consisted of 19 CSF samples from the same group of 66 patients, but from individuals who had no abnormal findings on neurologic examination, common clinicochemical tests, or neuroradiologic studies, our preliminary results suggest that tumors and hemorrhages may be differentiated by 1H MR spectroscopy. MR peak intensities relative to lactate peak intensity were used as variables in a statistical analysis to determine the significance of individual resonance intensities in predicting CNS abnormalities. The most important factors for diagnosis were analyzed by means of a multivariate general linear hypothesis and a principal component method. The most important factors for predicting CNS abnormalities in the studied diseases were creatinine, glucose, creatine, citrate, protein content, glutamine, amount of cells, and valine. By using this model for discriminant analysis, we could predict hemorrhages correctly in 88% of cases and tumors in 75% of cases. All samples of controls were determined correctly. In cases of brain infarctions, different signals were observed, which may lead to further characterization of such lesions. 1H MR spectroscopy may offer a simple means for further characterizing CNS lesions. However, this needs confirmation by a prospective study, which would include a larger patient population with different diseases.
authors.affiliation: Department of Radiology, University of Kiel, Federal Republic of Germany.
authors.forename: F
authors.initials: F
authors.lastname: Koschorek
authors.forename: H
authors.initials: H
authors.lastname: Gremmel
authors.forename: J
authors.initials: J
authors.lastname: Stelten
authors.forename: W
authors.initials: W
authors.lastname: Offermann
authors.forename: E
authors.initials: E
authors.lastname: Krüger
authors.forename: D
authors.initials: D
authors.lastname: Leibfritz
mesh_terms: D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000175:diagnosis; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000134:cerebrospinal fluid / Q000175:diagnosis; D007773:Lactates / Q000134:cerebrospinal fluid; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D013125:Spinal Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis
chemical_list: D007773:Lactates; D019344:Lactic Acid; D005947:Glucose