GABAergic agents-induced antinociceptive effect in mice.
The effect of GABA agonists, namely gamma aminobutyric acid, muscimol, sodium valproate and baclofen was studied on radiant heat-induced nociception in mice. All of the drugs, with the exception of sodium valproate, enhanced the reaction time to radiant heat as effect per se. Concomitant administration of any of these agents with morphine showed a potentiation of morphine-induced analgesia. The GABA antagonists bicuculline and picrotoxin failed to reverse the antinociceptive effect; paradoxically both these agents showed antinociceptive effect per se and also enhanced the response due to morphine.
Aley
K O
KO
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Kulkarni
S K
SK
D000700:Analgesics; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009118:Muscimol / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000502:physiology*
D000700:Analgesics; D001418:Baclofen; D001640:Bicuculline; D009020:Morphine; D009118:Muscimol; D010852:Picrotoxin; D014635:Valproic Acid; D005680:gamma-Aminobutyric Acid