[Diagnostic significance of determining specific antibodies of various isotypes in patients with pulmonary tuberculosis].
The levels of antimycobacterial antibodies of three isotypes: IgG, IgA and IgM were determined in serum of 153 patients with pulmonary tuberculosis and 136 healthy donors by the solid phase enzyme immunoassay with the sonicate as the antigen. A significant and highly reliable increase in the average levels of the antimycobacterial antibodies of the IgG, IgA and IgM classes in the serum of the patients was detected as compared to the healthy persons. A significant increase (probability of 97.5 per cent) in the antibody level in comparison to that in the healthy persons was observed in 26, 31 and 22 per cent of the patients in regard to IgG, IgA and IgM antibodies, respectively. It was shown that in every patient the level of one particular antibody isotype increased. A simultaneous significant increase in the levels of two or three antibody types was extremely rare. In this connection it was recommended to use a combined diagnostic test implying simultaneous determination of all the three antibody isotypes which provided higher frequency of tuberculosis detection (up to 67 per cent).
Titanian
A S
AS
Selitskaia
R P
RP
Svistunova
A S
AS
D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Diagnosticheskoe znachenie opredeleniia spetsificheskikh antitel raznykh izotipov u bol'nykh tuberkulezom legkikh.