The inhibitory effect of bis[2-[(E)-2-octenoylamino]ethyl] disulfide on the cyclooxygenase pathway.
Bis[2-[(E)-2-octenoylamino]ethyl] disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation. Based on these results, we then investigated the inhibitory effect of compd. I-3 on thromboxane B2 formation from arachidonic acid in rat platelets, and prostaglandin I2 formation in rat aortae. Compound I-3 inhibited both thromboxane B2 and prostaglandin I2 formation, suggesting that it has an inhibitory effect on cyclooxygenase. The inhibitory effect of compd. I-3 was confirmed in experiments using a crude preparation of sheep seminal vesicle microsomal prostaglandin synthetase. These findings suggested that compd. I-3 has an inhibitory effect on cyclooxygenase activity, like nonsteroidal anti-inflammatory drugs.
Mimura
T
T
Nakajima
H
H
Tsujikawa
K
K
Yasuda
N
N
Haruyama
M
M
Okabe
M
M
Iwai
M
M
Yokoyama
K
K
D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013440:Sulfides / Q000494:pharmacology*
D002219:Carbamates; D016861:Cyclooxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D013440:Sulfides; C055460:2-(3-octenoylamino)ethyl(carbamoylmethyl)sulfide