Effect of dopaminergic denervation and transplant-derived reinnervation on a marker of striatal GABAergic function.
Solid grafts of dopamine-containing fetal mesencephalon were placed adjacent to the striatum of rats with 6-hydroxydopamine lesions of ascending dopaminergic projections. These grafts resulted in a significant, although partial, reversal of the lesion-induced increase in striatal glutamic acid decarboxylase (GAD) when measured 3-4 months after the lesion. These results suggest that the grafted neurons can partly restore inhibitory control over striatal GABA neurons. In the same rats, the grafts partially reversed apomorphine-induced turning although amphetamine-induced turning was nearly abolished. It is likely that both apomorphine-induced behavior and striatal GAD activity reflect the sustained chronic influence of the graft on target neurons in striatum.
Segovia
J
J
Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007.
Meloni
R
R
Gale
K
K
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D003714:Denervation; D004298:Dopamine / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation*; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D006892:Hydroxydopamines; D005680:gamma-Aminobutyric Acid; D016627:Oxidopamine; D000661:Amphetamine; D005968:Glutamate Decarboxylase; D001058:Apomorphine; D004298:Dopamine