Role of CD4+ T-lymphocytes in rejection by mice of fetal pig proislet xenografts.
The role of T-lymphocyte subpopulations in the rejection of fetal pig proislet (islet precursor) xenografts in mice was examined with in vivo administration of monoclonal antibodies (MoAbs) to CD4+ (GK 1.5) and CD8+ (49-11.1) T-lymphocyte subsets. The data indicate that the rejection process is T-lymphocyte dependent and mediated by CD4+ T-lymphocytes. The in vivo administration of MoAbs specific for graft-borne pig leukocytes failed to prevent xenograft rejection in fully immunocompetent transplant recipients.
Wilson
J D
JD
Department of Endocrinology, Woden Valley Hospital, Australia.
Simeonovic
C J
CJ
Ting
J H
JH
Ceredig
R
R
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D016827:CD8 Antigens; D006084:Graft Rejection; D007515:Islets of Langerhans / Q000196:embryology; D016381:Islets of Langerhans Transplantation; D051379:Mice; D008808:Mice, Inbred CBA; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology*; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens