The effect of fleroxacin on hepatic drug metabolism in the rat.
Pretreatment of rats with repeated i.p. doses of fleroxacin had no effect on the hepatic O- and N-demethylation of p-nitroanisole (PN) and aminopyrine (A) respectively, on the p-hydroxylation of aniline or on the hepatic levels of cytochrome P-450 and protein content. Addition of fleroxacin directly to incubation mixtures reduced PN O-demethylase activity significantly but did not affect the other two oxidative reactions. The N-oxide metabolite increased PN O-demethylation by 16% whereas the N-demethylated metabolite decreased the N-demethylation of A by 10%. Concomitant administration or pretreatment with fleroxacin had no effect on antipyrine's elimination kinetic parameters.
Grech-Bélanger
O
O
Ecole de pharmacie, Université Laval, Québec, Canada.
Francoeur
J
J
Le Bel
M
M
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000983:Antipyrine / Q000378:metabolism; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D016576:Fleroxacin; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D004364:Pharmaceutical Preparations; D002939:Ciprofloxacin; D003577:Cytochrome P-450 Enzyme System; D016576:Fleroxacin; D000983:Antipyrine