Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.
Tumorous amyloid deposits in the nasal mucosa of two horses differed from generalized AA-amyloidosis with respect to clinical features, organ distribution, and resistance to KMnO4 treatment. Using a panel of antibodies directed against different human amyloid fibril proteins and employing the peroxidase-anti-peroxidase (PAP) technique, we showed the described equine amyloid to be A lambda-type, as demonstrated by immunohistochemical cross-reactivity. Consequently, we identified a second amyloid class in horses and showed that immunoglobulin light-chain-derived amyloid may also be present in animals.
Linke
R P
RP
Institut für Immunologie, Universität München, Federal Republic of Germany.
Trautwein
G
G
D000682:Amyloid / Q000032:analysis / Q000276:immunology; D000686:Amyloidosis / Q000150:complications / Q000276:immunology*; D000818:Animals; D003429:Cross Reactions; D005260:Female; D006734:Horse Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006736:Horses; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D009297:Nasal Mucosa / Q000032:analysis / Q000473:pathology; D009669:Nose Neoplasms / Q000032:analysis / Q000150:complications / Q000662:veterinary*
D000682:Amyloid; D007146:Immunoglobulin lambda-Chains