title: Myocardial potassium uptake during experimental cardiopulmonary resuscitation.
abstract: Changes in myocardial K+ handling were examined during ventricular fibrillation and subsequent CPR in ten domestic swine. During ventricular fibrillation, there was initial K+ efflux from the myocardium which was followed by myocardial K+ uptake during precordial compression. After successful defibrillation, a washout in K+ was observed. Coronary potassium clearance was inversely related to the myocardial [H+], PCO2, and lactate production. A negative correlation between cardiac vein [K+] and myocardial [H+] was observed (r = .88), supporting the concept that H+ extrusion is associated with K+ uptake of myocardial cells. Normal conditions were re-established within 60 min after restoration of spontaneous circulation. The myocardial uptake of K+ during CPR contrasted with increased K+ efflux from other tissues such that there were net increases in the K+ content of arterial and mixed venous blood. The implications of such myocardial K+ uptake during CPR on resuscitability is the subject of continuing study.
authors.affiliation: Department of Medicine, University of Health Sciences/The Chicago Medical School, IL 60064.
authors.forename: M
authors.initials: M
authors.lastname: von Planta
authors.forename: M H
authors.initials: MH
authors.lastname: Weil
authors.forename: R J
authors.initials: RJ
authors.lastname: Gazmuri
authors.forename: E C
authors.initials: EC
authors.lastname: Rackow
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D006439:Hemodynamics; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D012151:Resuscitation / Q000379:methods*; D013552:Swine; D014693:Ventricular Fibrillation / Q000628:therapy
chemical_list: D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D011188:Potassium