High urinary excretion of glycosaminoglycans: a possible marker of glomerular involvement in diabetes.
Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans. A lysine provocative test in these subjects disclosed abnormal urinary excretion of albumin, unlike findings obtained in insulin-dependent diabetic patients with normal urinary excretion rates of glycosaminoglycans. These data support the hypothesis that high urinary excretion of glycosaminoglycans is a marker of glomerular involvement in diabetes mellitus.
Gambaro
G
G
Institute of Internal Medicine, University of Padova, Italy.
Cicerello
E
E
Mastrosimone
S
S
Lavagnini
T
T
Baggio
B
B
D000328:Adult; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000652:urine; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008239:Lysine; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006025:Glycosaminoglycans; D008239:Lysine