[The thrombocyte-activation factor and endotoxin-induced thrombocyte activation].
The effect of PAF in aggregation of platelets induced by endotoxin was studied in experiments in vitro. It is indicated that in high concentration (1.10(-7)-1.10(-6) M) PAF did not affect the degree of aggregation of platelets induced by lipopolysaccharides (LPS) S. typhimurium and N. meningitidis. Successive addition to PRP LPS and PAF or joint addition of PAF and LPS did not change the degree of aggregation of each inductor or their sum. A lower concentration of PAF (1.10(-11)-1.10(-9) M) and endotoxin caused a more expressive aggregation of platelets than their successive addition. Stimulating activity of PAF on endotoxin-induced aggregation, perhaps, is caused by involvement of metabolism of arachidonic acid during blood platelets activation.
Lomazova
K D
KD
Poliakova
A M
AM
Astrina
O S
OS
Tsukerman
D B
DB
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D009345:Neisseria meningitidis; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D012486:Salmonella typhimurium
D004731:Endotoxins; D008070:Lipopolysaccharides; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate
Faktor aktivatsii trombotsitov i éndotoksinindutsirovannaia aktivatsii trombotsitov.