Hypoxia and hypercapnia increase the sympathoadrenal medullary functions in anesthetized, artificially ventilated rats.
Graded hypoxia (FETO2 14-6%) and hypercapnia (FETCO2 6-10%), which were applied for 45s and 2 min, respectively, to urethane anesthetized and artificially ventilated rats produced an increase in adrenal sympathetic efferent nerve activity in parallel with increases in adrenaline and noradrenaline secretion measured in the adrenal venous effluent. Percentage increases in adrenaline and noradrenaline were almost equal. In rats whose carotid sinus nerves (CSN) were bilaterally cut, hypoxia did not produce any effect on adrenal sympathetic nerve activity or catecholamine secretion. In contrast, excitatory adrenal nerve and catecholamine secretory responses to hypercapnia remained unchanged in CSN denervated rats. After severing a splanchnic nerve whose branches innervated the adrenal gland, while maintaining the resting level of catecholamine secretion by low-frequency stimulation of the peripheral end of the splanchnic nerve, hypoxia did not produce any increase in catecholamine secretion. Hypercapnia (FETCO2 8 and 10%), however, induced catecholamine secretion from denervated adrenal medulla, although the magnitude of the response was significantly lower than that in animals with adrenal nerve intact. It is concluded that hypoxia stimulates the adrenal medulla via the carotid chemoreceptor reflex whereas hypercapnia acts mainly via mechanisms besides carotid chemoreceptors such as central chemoreceptors with some direct stimulatory effect on the adrenal medulla. The functional significance of these dual mechanisms of sympathoadrenal excitation during hypoxia and hypercapnia is discussed.
Biesold
D
D
Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Kurosawa
M
M
Sato
A
A
Trzebski
A
A
D000313:Adrenal Medulla / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002346:Carotid Sinus / Q000294:innervation; D002395:Catecholamines / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000502:physiology; D004837:Epinephrine / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013153:Splanchnic Nerves / Q000601:surgery; D013564:Sympathetic Nervous System / Q000502:physiology*; D012122:Ventilators, Mechanical
D002395:Catecholamines; D002245:Carbon Dioxide; D010100:Oxygen; D004837:Epinephrine