[A hyperlipidic diet and acute pancreatitis: experimental study in rats].
After acute pancreatitis was induced, the residual pancreatic tissue contents were evaluated in two series of rats fed with diets that differed in the lipidic composition: 1--high lipid and balanced protein diet; 2--balanced diet. Total protein, nucleic acids, trypsinogen, chymotrypsinogen were quantified in the pancreatic tissue; amylase activity was measured in the pancreatic tissue and serum under the following conditions: 1--in rats fed "ad libitum" (groups CB and CL); 2--in rats submitted to a fast of 30 hs (groups JB and JL) and 3--twenty-four hours after acute pancreatitis was induced (group B and L). The results obtained were statistically compared among groups with the same kind of diets, using ANOVA and the Tukey test. Student t-test was used to compare the same parameters among similar groups with different diets (p less than 0.05). In comparison with the groups under same regimen it was verified that the pancreatic enzymes content didn't change in fasting groups, but did in PA groups. It was also found that trypsin was increased in all groups, RNA/DNA decreased and total protein increased in AP group in rats fed with hyperlipidic diet. It is concluded that high lipid intake can aggravate pancreatic injury.
Gonçalez
Y
Y
Coelho
A M
AM
Sampietri
S N
SN
Machado
M C
MC
Bettarello
A
A
Pinotti
H W
HW
D000208:Acute Disease; D000818:Animals; D004247:DNA / Q000097:blood; D004041:Dietary Fats / Q000009:adverse effects*; D005526:Food, Formulated; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010195:Pancreatitis / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D012313:RNA / Q000097:blood; D051381:Rats
D004041:Dietary Fats; D012313:RNA; D004247:DNA
Dieta hiperlipídica e pancreatite aguda: estudo experimental em ratos.