title: A new model for studying nutrition in peritonitis. The adverse effect of overfeeding.
abstract: In guinea pigs fed ad libitum, controlled intraperitoneal infusion of bacteria by an implanted 7-day osmotic pump resulted in peritonitis or abscess formation with a 50% survival 14-18 days after pump implantation. Administration of 125 kcal/kg/day of a diet found to be optimal for burned guinea pigs by continuous pump controlled feedings via a previously placed gastrostomy was well-tolerated, with a 62.5% mortality by Day 17. Administration of only 100 kcal/kg/day caused weight loss of approximately 17% after 16 days, but fewer animals died (42.8%, p = NS). Feeding either 150 kcal/kg/day or 175 kcal/kg/day caused death in all 25 animals (p less than 0.001) and their survival time was slightly shortened (p = NS) when compared with animals receiving 100 or 125 kcal/kg/day. This is the first animal model of peritonitis that permits incisive dissection of the relative influences of dietary composition on outcome, because survival can be extended to 2 weeks or more in the presence of continuing sepsis.
authors.affiliation: Department of Surgery, University of Cincinnati College of Medicine, Ohio.
authors.forename: J W
authors.initials: JW
authors.lastname: Alexander
authors.forename: S J
authors.initials: SJ
authors.lastname: Gonce
authors.forename: P W
authors.initials: PW
authors.lastname: Miskell
authors.forename: M D
authors.initials: MD
authors.lastname: Peck
authors.forename: H
authors.initials: H
authors.lastname: Sax
mesh_terms: D000818:Animals; D002149:Energy Intake; D004750:Enteral Nutrition / Q000009:adverse effects*; D004927:Escherichia coli Infections / Q000209:etiology / Q000628:therapy*; D005526:Food, Formulated; D005774:Gastrostomy; D006168:Guinea Pigs; D010538:Peritonitis / Q000209:etiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000209:etiology / Q000628:therapy*