Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and gamma-IFN levels in serum and cerebrospinal fluid.
Serum and cerebrospinal fluid (CSF) levels of interleukin-2 (IL-2), soluble IL-2 receptor (sIL-2R), and gamma-interferon (gamma-IFN) were measured in multiple sclerosis (MS) patients, human immunodeficiency virus type 1 (HIV-1)-infected patients and normal controls (NC). Increased levels of both IL-2 and sIL-2R were found in MS serum. Moreover, 11 of 50 MS patients showed detectable levels of IL-2 in the CSF. HIV-1-infected patients had increased levels of sIL-2R in serum and, less frequently, in the CSF. gamma-IFN was never detected in serum and CSF of all the patients studied. These findings confirm preliminary reports, further stress a systemic T-cell activation in MS, and support the hypothesis that an immunologic disorder exists in such patients.
Gallo
P
P
Institute of Neurology, University of Padova, School of Medicine, Italy.
Piccinno
M G
MG
Pagni
S
S
Argentiero
V
V
Giometto
B
B
Bozza
F
F
Tavolato
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D000328:Adult; D005260:Female; D006261:Headache / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000134:cerebrospinal fluid; D007376:Interleukin-2 / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D009497:Neurotic Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012016:Reference Values
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma