title: Purified follicle-stimulating hormone in polycystic ovary syndrome: slow administration is safer and more effective.
abstract: Twenty-seven infertile patients presenting with clomiphene citrate- (CC) resistant polycystic ovary syndrome (PCOS) were treated with purified urinary follicle-stimulating hormone (pFSH). We compared the conventional stepwise protocol with a slow protocol starting with 75 IU/d, not increased until 14 days, supplemented by human chorionic gonadotropins (hCG). The slow protocol was characterized by a slightly longer duration of stimulation but a more physiological ovarian response (mono- or biovulatory cycles in 70% versus 19% with the conventional protocol, less follicles, and a lower plasma estradiol [E2] resulting in significantly less discontinuation of treatment for risk of hyperstimulation or multiple birth). The pregnancy rate per cycle was higher with the slow protocol (23% versus 15%). The slow protocol could thus be the treatment of choice for CC-resistant PCOS, as it appeared safer and more effective.
authors.affiliation: Association EPARP, Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Buvat
authors.forename: M
authors.initials: M
authors.lastname: Buvat-Herbaut
authors.forename: G
authors.initials: G
authors.lastname: Marcolin
authors.forename: J L
authors.initials: JL
authors.lastname: Dehaene
authors.forename: P
authors.initials: P
authors.lastname: Verbecq
authors.forename: O
authors.initials: O
authors.lastname: Renouard
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D008593:Menopause / Q000378:metabolism; D006080:Ovarian Follicle / Q000473:pathology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D005640:Follicle Stimulating Hormone