Effect of rioprostil, a methyl-prostaglandin E1, on plasma level and renal excretion of beta-acetyldigoxin.
A single oral dose of rioprostil, a synthetic methyl-prostaglandin E1, together with or 2 h before ingestion of 0.8 mg beta-acetyldigoxin significantly delays the rate but does not change the extent of beta-acetyldigoxin absorption. However, repeated evening doses of rioprostil do not alter either the glycoside steady-state plasma levels or renal excretion.
Demol
P
P
Institute of Clinical Pharmacology, Pharma Research Centre Bayer AG, Wuppertal, FRG.
Wingender
W
W
Kuhlmann
J
J
D000113:Acetyldigoxins / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001682:Biological Availability; D004077:Digoxin / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D016630:Rioprostil
D000113:Acetyldigoxins; D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D004077:Digoxin; D016630:Rioprostil