Changes in forearm blood flow at elevated ambient temperature and their role in the apparent impairment of glucose tolerance.
1. Antecubital venous plasma glucose and insulin concentrations after ingestion of 75 g of glucose were higher in six normal subjects when studied at an ambient temperature of 33 degrees C at an ambient temperature of 23 degrees C; the mean area under the glucose-time curve increased from 833 at 23 degrees C to 990 mmol min-1 at 33 degrees C, that for insulin from 5300 to 7900 m-units min 1-1. 2. Core temperature was elevated by 0.5 degree C at 33 degrees C ambient, although there was no marked stress response as judged by plasma levels of catecholamines, cortisol and growth hormone; at 2 h after glucose ingestion, mean noradrenaline levels were lower at 33 degrees C than at 23 degrees C (1.1 at 33 degrees C vs 1.8 nmol/l at 23 degrees C), adrenaline slightly higher (0.18 at 33 degrees C vs 0.09 nmol/l at 23 degrees C), cortisol and growth hormone unchanged. 3. Forearm blood flow was markedly elevated at 33 degrees C ambient (mean total flow 9.1 at 33 degrees C vs 1.8 ml min-1 100 ml-1 at 23 degrees C), as were antecubital venous partial pressure of oxygen (mean 10.1 at 33 degrees C vs 5.6 kPa at 23 degrees C) and oxygen saturation (mean 92% at 33 degrees C vs 70% at 23 degrees C). There was a positive correlation between oxygen saturation and area under the glucose tolerance curve. 4. In separate experiments, arterialized glucose concentrations were measured after glucose ingestion at 23 degrees C ambient.(ABSTRACT TRUNCATED AT 250 WORDS)
Frayn
K N
KN
Sheik Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, U.K.
Whyte
P L
PL
Benson
H A
HA
Earl
D J
DJ
Smith
H A
HA
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D004361:Drug Tolerance; D005260:Female; D005542:Forearm / Q000098:blood supply*; D005947:Glucose / Q000493:pharmacokinetics*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012039:Regional Blood Flow; D013696:Temperature
D001786:Blood Glucose; D007328:Insulin; D002245:Carbon Dioxide; D005947:Glucose; D010100:Oxygen