Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor.
B cell activation was studied in B cells from B cell chronic lymphocytic leukemia (B-CLL) patients. After in vitro stimulation, these B cells showed extensive proliferation in the presence of high-molecular-weight B cell growth factor (BCGF). In contrast, this effect was not observed upon addition of recombinant interleukin-2 (IL-2). In agreement, upon stimulation, B cells expressed Bac-1 antigen but failed to acquire the IL-2 receptor. These results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients.
Alvarez-Mon
M
M
Departamento de Medicina, Universidad de Alcalá de Henares, España.
de la Hera
A
A
Gaspar
M L
ML
Orfao
A
A
Casas
J
J
Jordá
J
J
Durantez
A
A
D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002474:Cell-Free System; D002478:Cells, Cultured; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000502:physiology; D013601:T-Lymphocytes / Q000378:metabolism
D007136:Immunoglobulins; D007376:Interleukin-2; D007378:Interleukins; D015375:Receptors, Interleukin-2; D015847:Interleukin-4