title: Chronic myeloid leukemia associated with pure red cell aplasia and terminating in promyelocytic transformation.
abstract: After intermittent treatment with busulphan over a 7-year period for chronic myeloid leukemia (CML) in chronic phase, a 39-year-old female developed leukocytosis in association with pure red cell aplasia (PRCA). Bone marrow examination confirmed erythroid aplasia, and culture revealed a total absence of erythroid progenitor cells. The patient then was treated with azathioprine, corticosteroids, cyclophosphamide, plasma exchange, and cyclosporin A, but she remained erythroblastopenic and transfusion dependent for more than a year, at which time a promyelocytic transformation supervened. The authors propose that this sequence of events, hitherto unreported, is a manifestation of the multistep progression of CML.
authors.affiliation: Institute of Hematology, Medical School of Belgrade, Yugoslavia.
authors.forename: A
authors.initials: A
authors.lastname: Mijović
authors.forename: Z
authors.initials: Z
authors.lastname: Rolović
authors.forename: A
authors.initials: A
authors.lastname: Novak
authors.forename: L
authors.initials: L
authors.lastname: Biljanović-Paunović
authors.forename: D
authors.initials: D
authors.lastname: Tomin
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006098:Granulocytes / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000473:pathology / Q000628:therapy; D010951:Plasma Exchange; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000473:pathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents