title: Functional assessment of colonic interposition with 99Tcm-labeled milk.
abstract: A prospective study was performed to evaluate the use of radionuclide imaging in the assessment of patients who have undergone esophageal reconstruction. Dynamic radionuclide imaging was performed on ten patients aged 11 months to 11 years who had undergone colon interposition via the normal esophageal route for esophageal atresia. Patients were considered clinically unsatisfactory if at the time of imaging feeding was troubled, or if weight gain had fallen to below the third centile before operation and remained below after operation. Each patient underwent erect imaging with a small milk feed labeled with 10 to 20 MBq (250 to 500 muCi) 99Tcm DTPA adjusted according to body surface area; supine studies were subsequently performed on five patients. All five clinically unsatisfactory patients showed conduit emptying delayed beyond 45 minutes and/or spontaneous reflux, significantly different from the clinically satisfactory patients (X2 = 6.4, P less than .02). Conduit complications were subsequently identified in three of the five clinically unsatisfactory patients. Radionuclide imaging with radiolabeled milk was found to be well tolerated, and obtained results that were clinically useful. These results suggest that dynamic radionuclide imaging can be more widely applied in the assessment of esophageal substitutes.
authors.affiliation: Wessex Regional Center for Paediatric Surgery, Southampton General Hospital, England.
authors.forename: R
authors.initials: R
authors.lastname: Sutton
authors.forename: H
authors.initials: H
authors.lastname: Sutton
authors.forename: D M
authors.initials: DM
authors.lastname: Ackery
authors.forename: N V
authors.initials: NV
authors.lastname: Freeman
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000503:physiopathology / Q000601:surgery*; D004933:Esophageal Atresia / Q000601:surgery*; D004944:Esophagoplasty; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008892:Milk; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012086:Reoperation; D013667:Technetium; D015091:beta-Alanine / Q000031:analogs & derivatives*
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C054752:technetium TC 99m 2,3-diaminopropionic acid; D015091:beta-Alanine; D013667:Technetium; D000409:Alanine