Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema.
D-Penicillamine administered orally in daily doses of 300 mg or 400 mg to pregnant rats during the last six days of gestation caused marked growth retardation, a decrease in the lung weight to body weight ratio and histological features characteristic of pulmonary emphysema in the newborn animals studied. It was also demonstrated that a normal diet given to the dams for a period of three weeks after delivery did not restore the lung tissue of the offspring to normal.
Yurdakök
M
M
Topaloğlu
H
H
Haziroğlu
R
R
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011656:Pulmonary Emphysema / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D051381:Rats
D010396:Penicillamine