title: Adherence and its management in clinical trials: implications for arthritis treatment trials.
abstract: Adherence in clinical trials is a consistent problem regardless of the disease process or organ system under investigation. In this paper data and examples from clinical trials examining cardiovascular diseases are used as the basis for a review of various adherence principles. Issues reviewed include: the importance of adherence in clinical trials, an overall program for adherence in clinical trials, and specific issues in adherence from arthritis clinical trials. Special attention is given to a program for the prevention of reduced adherence for participants of a clinical trial as well as acute and chronic intervention plans for those with good adherence and those with reduced adherence in a clinical trial.
authors.forename: J L
authors.initials: JL
authors.lastname: Probstfield
mesh_terms: D001168:Arthritis / Q000523:psychology* / Q000628:therapy; D001521:Behavior Therapy; D002986:Clinical Trials as Topic; D003376:Counseling; D006801:Humans; D010349:Patient Compliance