title: Malignant melanoma and extramammary Paget's disease in the same patient.
abstract: Axillary Paget's disease was found in a 34-year-old man who died of metastatic malignant melanoma. The primary cutaneous malignant melanoma was diagnosed 6 years before the patient's demise and was confirmed by the presence of melanin, a positive dopa reaction, and immunohistochemical demonstration of S-100 protein in neoplastic cells. Postmortem examination revealed Paget's disease of the axillary skin in addition to widespread metastases of malignant melanoma. Paget cells were positive for periodic acid-Schiff reaction and alcian blue. They were also immunohistochemically positive for carcinoembryonic antigen, but were negative for S-100 protein. This association of malignant melanoma and Paget's disease in the same person has not, to the best of our knowledge, been described before.
authors.affiliation: Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: T
authors.initials: T
authors.lastname: Moriya
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Takei
mesh_terms: D000328:Adult; D001365:Axilla; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008543:Melanins / Q000032:analysis; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010145:Paget Disease, Extramammary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D008543:Melanins