Veto function in vitro and in vivo.
A CTLp recognizing another cell, called veto cell, is suppressed by that veto cell. The veto cell can itself be a CTL. For the veto function, the TCR of the veto cell is not required, hence the veto function is a backward action of CTL. Since, from the point of view of the veto cell, only self-reactive CTLp are suppressed, the veto function could be a mechanism for maintaining self tolerance of CTL. The characteristics of veto function in vitro and in vivo are discussed, as well as the potential physiological relevance.
Rammensee
H G
HG
Basel Institute for Immunology, Switzerland.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006086:Graft vs Host Disease / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D007108:Immune Tolerance / Q000502:physiology*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology*; D014181:Transplantation Immunology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II