Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes.
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions an increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
Majone
F
F
Department of Biology, University of Padua, Italy.
Busulini
L
L
Capozzi
A
A
Bianco
N
N
Saggioro
D
D
Levis
A G
AG
Bordin
F
F
D000818:Animals; D004247:DNA / Q000032:analysis; D004261:DNA Replication; D004279:DNA, Viral / Q000032:analysis; D003839:Deoxyadenosines / Q000494:pharmacology; D008214:Lymphocytes / Q000032:analysis / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D008979:Moloney murine leukemia virus / Q000235:genetics; D011533:Proviruses / Q000187:drug effects / Q000235:genetics; D012093:Replicon; D012854:Sister Chromatid Exchange / Q000187:drug effects
D004279:DNA, Viral; D003839:Deoxyadenosines; D008937:Mitomycins; D016685:Mitomycin; D004247:DNA