Direct ovulatory response with human menopausal gonadotropin of FSH/LH ratio 4 to 1.
The experiment was designed to examine if human menopausal gonadotropin (Gonadoryl, GNR, Mochida, Tokyo) influences the ovary and induces ovulation. When fifteen I.U. of GNR 4 (the ratio of FSH to LH is 4 to 1) was given on 28 days of age to immature female rats, ovulation was observed within 24 hours. Neither administration of GNR 1.6 (FSH to LH ratio is 1.6 to 1) nor GNR 3.1 (FSH to LH ratio is 3.1 to 1) induced ovulation. Administration of sodium pentobarbital (Nembutal) on the afternoon in GNR 4 treated rats did not block ovulation. It infers that GNR 4 acts on the ovary directly and induces ovulation within 24 hours.
Koyama
T
T
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio.
Hagino
N
N
Cothron
A W
AW
Saito
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D007986:Luteinizing Hormone / Q000008:administration & dosage*; D008596:Menotropins / Q000032:analysis / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D010424:Pentobarbital