title: Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas.
abstract: The effects of sodium salts of medium-chain fatty acids, caprylate and caprate, on the penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas in vitro were examined. Sodium caprylate (0.5 and 1% 2/v) marginally increased the corneal penetration of 6-carboxyfluorescein, a hydrophilic compound. However, it did not change the corneal penetration of FITC-dextran (mol.wt 4000). Sodium caprate (0.5 and 1% w/v) markedly increased the corneal penetration of these compounds.
authors.affiliation: Department of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Morisaka
mesh_terms: D000818:Animals; D001682:Biological Availability; D002210:Caprylates / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003315:Cornea / Q000378:metabolism*; D003652:Decanoic Acids / Q000494:pharmacology; D003911:Dextrans / Q000493:pharmacokinetics; D004594:Electrophysiology; D005227:Fatty Acids / Q000494:pharmacology*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives*; D005452:Fluoresceins / Q000493:pharmacokinetics; D006820:Hyaluronic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D011817:Rabbits; D013268:Stimulation, Chemical
chemical_list: D002210:Caprylates; D003652:Decanoic Acids; D003911:Dextrans; D005227:Fatty Acids; D005452:Fluoresceins; C015219:fluorescein isothiocyanate dextran; C024098:6-carboxyfluorescein; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D016650:Fluorescein-5-isothiocyanate; C031492:octanoic acid