title: [Interchangeability of mutagens during fractionated effects of unequal concentrations of alkylating agents].
abstract: The ability of thiophosphamide and dipin to substitute for each other in "clastogenic adaptation" of human lymphocytes was investigated at Go phase. There were used 5 low concentrations of mutagens 2, 0.2, 2.10(-2), 2.10(-3), 2.10(-4) micrograms/ml and the high one of 20 micrograms/ml with which cells were treated 2 hr after the effect of low concentrations. The "protective" concentrations for both mutagens were 0.2, 2.10(-2), 2.10(-3) micrograms/ml. The pretreatment with thiophosphamide caused the decrease in chromatid aberrations in "challenge" treatment with dipin, the pretreatment with dipin caused the decrease in chromosome aberrations in "challenge" treatment with thiophosphamide.
authors.forename: A N
authors.initials: AN
authors.lastname: Tulina
authors.forename: A N
authors.initials: AN
authors.lastname: Chebotarev
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D001388:Aziridines / Q000008:administration & dosage / Q000494:pharmacology; D002478:Cells, Cultured; D002842:Chromatids; D002869:Chromosome Aberrations; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens; D013852:Thiotepa / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000477:Alkylating Agents; D001388:Aziridines; D009153:Mutagens; D013852:Thiotepa; C007526:dipin
vernacular_title: Vzaimozameniaemost' mutagenov pri fraktsionirovannom vozdeĭstvii neravnymi kontsentratsiiami alkiliruiushchikh agentov.