Rioprostil in the healing of duodenal ulceration: a short report.
A preliminary analysis on a group of 182 patients participating in a large, multicentre trial comparing nocturnal rioprostil, 600 micrograms and ranitidine, 300 mg, is presented. The results are confined to the ulcer healing properties. Healing rates are 61% and 77%, respectively, at 4 weeks, and 86% and 96% at 8 weeks. The advantage of ranitidine reaches statistical significance at 8 weeks (p less than 0.05). About 20% of patients taking rioprostil report loose bowels or diarrhoea, but only two patients withdraw for this problem.
Whorwell
P J
PJ
Department of Medicine, University Hospital of South Manchester, UK.
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D011458:Prostaglandins E / Q000627:therapeutic use*; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D016630:Rioprostil
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil; D011899:Ranitidine