Tumor necrosis factor and interferon gamma inhibit the development of radiation-induced thymic lymphomas in C57BL/Ka mice.
Recombinant tumor necrosis factor and/or gamma-interferon were injected into C57BL/Ka mice after completion of a whole body split dose irradiation, which usually induces thymic lymphomas in more than 90% of the animals. The survival and the incidence of thymic lymphomas were significantly reduced in the cytokine-injected irradiated mice. The protective effect was similar to that obtained by grafting normal bone marrow cells after irradiation. The mechanisms of lymphoma inhibition by TNF or IFN-gamma are discussed.
Boniver
J
J
Department of Pathology, University Hospital of Liege, Belgium.
Humblet
C
C
Defresne
M P
MP
D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000627:therapeutic use*; D008223:Lymphoma / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013953:Thymus Neoplasms / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma