title: [In vitro evaluation of the activity and interactions of cefotaxime and its metabolite desacetylcefotaxime against strains of enterobacteria, staphylococci and Bacteroides fragilis isolated from hospital infections].
abstract: The paper reports a study of the activity of cefotaxime and its metabolite, desacetylcefotaxime, and the association of the two compounds, against 699 strains of enterobacteria, staphylococci and Bacteroides fragilis of hospital origin. The results of the study confirm the good activity of the drug and the less satisfactory activity of its metabolite, which is nevertheless comparable to second generation cephalosporins. The 1:1 association of the two compounds showed synergism in percentages ranging from 3.7% to 15% of strains, and partial synergies of indifference to the remaining strains. Antagonisms were only observed against some M. morgani and H. alvei strains.
authors.forename: E
authors.initials: E
authors.lastname: Pitzus
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000302:isolation & purification; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: C029281:desacetylcefotaxime; D002439:Cefotaxime
vernacular_title: Valutazione in vitro dell'attività e dell'interazione tra cefotaxime ed il suo metabolita desacetilcefotaxime su ceppi di enterobatteri, stafilococchi e Bacteroides fragilis d'isolamento ospedaliero.