Neural tube defects: considerations on the pathogenesis and correlation with myelodysplasia in man. I. Embryological aspects.
In this first part, a brief review of some of the general embryological, pathogenetical and experimental aspects of neural tube defects is made. In particular, the importance of the extracellular matrix and glycosaminoglycans is discussed in relation with neural tube defects.
Di Rocco
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Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy.
Rende
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M
D000818:Animals; D002454:Cell Differentiation; D003094:Collagen / Q000096:biosynthesis; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000473:pathology; D006025:Glycosaminoglycans / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D051379:Mice; D009436:Neural Tube Defects / Q000196:embryology* / Q000209:etiology* / Q000473:pathology
D006025:Glycosaminoglycans; D003094:Collagen; D006821:Hyaluronoglucosaminidase