title: Effect of halothane, enflurane and isoflurane on carotid body chemoreceptor activity in the rabbit and the cat.
abstract: The response of the carotid body chemoreceptors to administration of halothane, enflurane and isoflurane was tested in the rabbit and cat. In the steady-state all three volatile anaesthetics, in doses up to 1%, were mildly chemodepressant. The oxygen response curves were shifted downwards, but hypoxic stimuli below 5.3 kPa overcame this chemodepression. Two-point carbon dioxide response curves were also shifted downwards, but with no change in slope. Possible mechanisms involved in the chemoreceptor response to transient and steady-state anaesthetic administration are discussed.
authors.affiliation: Department of Anaesthesia, King's College School of Medicine and Dentistry, London.
authors.forename: J
authors.initials: J
authors.lastname: Ponte
authors.forename: C L
authors.initials: CL
authors.lastname: Sadler
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology; D002344:Carotid Body / Q000187:drug effects*; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004737:Enflurane / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D007530:Isoflurane / Q000494:pharmacology; D010100:Oxygen / Q000502:physiology; D011817:Rabbits; D013562:Sympathectomy
chemical_list: D000777:Anesthetics; D002245:Carbon Dioxide; D004737:Enflurane; D007530:Isoflurane; D010100:Oxygen; D006221:Halothane