Intraperitoneal penetration of cefpirome.
Twenty-six patients undergoing elective gastrointestinal surgery received a 1 g intravenous dose of cefpirome before operation. Serum and peritoneal fluid samples, obtained 0.5-7.6 h following administration, were assayed for cefpirome by a microbiological assay. The serum half-life of cefpirome was 2.1 h. The mean concentration of cefpirome in peritoneal fluid 0-2 h after administration was 44.4 micrograms/ml. The half-life of cefpirome in peritoneal fluid was 2 h, with mean concentrations of less than 10 micrograms/ml measured 6 h after administration. The mean percentage of intraperitoneal penetration of cefpirome over the study period was 97.7%. The therapeutic implications are discussed.
Kavi
J
J
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
Ashby
J P
JP
Wise
R
R
Donovan
I A
IA
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome