[Morphometry and kinetics of jejunal epithelium in rats with niacin deficiency].
In niacin deficient rats, it was performed a kinetic and morphometric study of jejunal epithelium. It was observed that the deficient animals showed less villosity (515.1 mu x 570.1 mu; p less than 0.008), enterocyte (35.3 mu x 38.5 mu; p less than 0.004) and mitotic index (4.4% x 5.7%; p less than 0.001) and bigger crypt (238.0 mu x 186.1 mu; p less than 0.001) and cellular renovation time (22.9h x 17.8h; less than 0.001) according to control animals. It is suggested that NAD (nicotinamide-adenine dinucleotide) deficiency can be responsible for the observed alterations.
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Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.
Meneghelli
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UG
D000818:Animals; D001835:Body Weight; D004032:Diet; D004848:Epithelium / Q000473:pathology; D007583:Jejunum / Q000473:pathology*; D008297:Male; D008867:Microtomy; D008940:Mitotic Index; D009525:Niacin / Q000172:deficiency*; D051381:Rats; D011919:Rats, Inbred Strains
D009525:Niacin
Morfometria e cinética do epitélio jejunal em ratos com deficiência de niacina.