title: Carbon dioxide mandatory ventilation (CO2MV): a new method for weaning from mechanical ventilation. Description and comparative clinical study with I.M.V. and T. tube method in COPD patient.
abstract: We describe a new technique specially designed for weaning from mechanical ventilation: carbon dioxide mandatory ventilation (CO2MV). CO2MV is based on feedback between end tidal expired partial pressure of carbon dioxide and ventilatory mode, controlled or spontaneous. In order to evaluate its real interest we performed a randomized prospective study, CO2MV vs Intermittent Mandatory Ventilation (IMV) and T. Tube Method (TTM). Fourty-two adult patients with chronic obstructive pulmonary disease entered this study at the end of acute respiratory failure requiring mechanical ventilatory support. We observed a better stability of arterial blood gas during weaning with CO2MV and an increase in success rate (CO2MV 13/14 - IMV 5/14 - TTM 10/14). From this study CO2MV seems available for weaning of COPD patients. Nevertheless, further studies are required to appreciate its real clinical interest.
authors.affiliation: Department of Réanimation polyvalente, University of Lille II, France.
authors.forename: C
authors.initials: C
authors.lastname: Chopin
authors.forename: M C
authors.initials: MC
authors.lastname: Chambrin
authors.forename: J
authors.initials: J
authors.lastname: Mangalaboyi
authors.forename: P
authors.initials: P
authors.lastname: Lestavel
authors.forename: F
authors.initials: F
authors.lastname: Fourrier
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000502:physiology*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012189:Retrospective Studies; D013990:Tidal Volume; D015300:Ventilator Weaning / Q000379:methods*
chemical_list: D002245:Carbon Dioxide