title: Absorption of recombinant human growth hormone (rhGH) following intraperitoneal instillation.
abstract: Recombinant human growth hormone (rhGH) was instilled intraperitoneally (i.p.) in six children undergoing continuous cycling peritoneal dialysis (CCPD). Immediate absorption was noted with either 0.250 mg/kg, 0.125 mg/kg, or 0.050 mg/kg of rhGH. Peak serum growth hormone (GH) levels occurred 4 and 8 h following i.p. administration, and the serum GH levels had returned to baseline values at 24 h. In one patient, a higher dosage demonstrated adequate absorption, whereas the lower dosage produced a flat absorption curve. These data indicate that daily i.p. administration of rhGH could be utilized in clinical trials directed toward improving the growth velocity of children undergoing CCPD.
authors.affiliation: Department of Pediatrics, UCLA Center for the Health Sciences.
authors.forename: R N
authors.initials: RN
authors.lastname: Fine
authors.forename: S E
authors.initials: SE
authors.lastname: Fine
authors.forename: B M
authors.initials: BM
authors.lastname: Sherman
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019382:Human Growth Hormone; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000379:methods*; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone