Applications of molecular graphics for the study of recognition.
Molecular recognition depends upon a precise structural complementarity between the pairs of molecules concerned. For example, the strong affinity between an antigen and its specific antibody can be negated by replacement of a single amino-acid residue. The protein beta-lactoglobulin from cows' milk is a member of a family of ligand-binding proteins with dual molecular recognition properties--for ligand and for a target receptor cell. This paper describes the use of molecular mechanics and energy calculations in attempting to understand the basis of such molecular recognition phenomena.
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Astbury Department of Biophysics, University of Leeds, UK.
D000818:Animals; D002417:Cattle; D003196:Computer Graphics; D007782:Lactoglobulins / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular
D007782:Lactoglobulins; D008024:Ligands