Effect of oral immunization with Pseudomonas aeruginosa on the development of specific antibacterial immunity in the lungs.
Oral administration of Pseudomonas aeruginosa to rats elicited a systemic and mucosal antibody response in the intestinal and respiratory tracts. The antibody response did not influence the course of the disease when immunized animals were subsequently challenged by the introduction of viable bacteria into the lungs.
Freihorst
J
J
Department of Pediatrics, Children's Hospital, Buffalo, New York 14222.
Merrick
J M
JM
Ogra
P L
PL
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008168:Lung / Q000276:immunology / Q000382:microbiology*; D008297:Male; D011552:Pseudomonas Infections / Q000276:immunology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G