[Lipoxin B, an enhancing factor of spontaneous platelet aggregation in whole blood].
The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation.
Khshivo
A L
AL
Nekrasov
A S
AS
Lankin
V Z
VZ
Kholodov
A Iu
AIu
Vikhert
A M
AM
Popov
G K
GK
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D006893:Hydroxyeicosatetraenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D044045:Lipoxins; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D044045:Lipoxins; D016718:Arachidonic Acid; C034922:5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid; C042651:lipoxin B4
Lipoksin B--faktor usileniia spontannoĭ agregatsii trombotsitov v tsel'noĭ krovi.