Effect of rioprostil, 600 micrograms, on the interdigestive myoelectrical activity of the humans small intestine.
The effect of rioprostil, a PGE1 analogue, on the interdigestive motility of the upper human small intestine was investigated in 8 normal volunteers in a double-blind, placebo-controlled study. Rioprostil was administered intraduodenally in a dose of 600 micrograms. The myoelectrical activity was recorded simultaneously at 8 different levels of the jejunum, at 10 cm intervals. Rioprostil, 600 micrograms, does not disrupt the migrating motor complex (MMC) and does not change the characteristics of phase 3 of the MMC, except for an increased propagation velocity. The main effect of rioprostil, 600 micrograms, is a marked inhibition of phase 2 contractions without induction of propulsive motility patterns during phase 2. This may explain why rioprostil in a dose of 600 micrograms is not markedly diarrheogenic in man.
Vantrappen
G
G
Department of Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium.
Janssens
J
J
D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007583:Jejunum / Q000502:physiology*; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D016630:Rioprostil
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil