Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis.
Humoral immunity was evaluated in seven children undergoing continuous ambulatory peritoneal dialysis (CAPD). Five children (71%) had serum immunoglobulin levels which were more than 2 SD below the mean for age. One mechanism contributing to hypogammaglobulinemia was loss via the peritoneal membrane. Daily losses of IgG into peritoneal dialysis effluents represented 7%-29% of normal daily IgG synthesis, and losses increased with duration of CAPD therapy. Despite the observed hypogammaglobulinemia, all children had protective antibody responses to immunization.
Fivush
B A
BA
Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD 21205.
Case
B
B
May
M W
MW
Lederman
H M
HM
D001826:Body Fluids / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010529:Peritoneal Cavity; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D005719:gamma-Globulins / Q000032:analysis*
D007136:Immunoglobulins; D005719:gamma-Globulins