Predictive value of hormonal profiles before stimulation for in vitro fertilization.
Ovarian responses to stimulation for in vitro fertilization by clomiphene citrate menotropins have been correlated to the hormonal profiles determined during spontaneous cycles. The authors found 80% of high plasmatic luteinizing hormone (LH) and/or androgens levels associated with an inappropriated response: premature LH surge, multifollicular ovarian response, or dissociated cystic response, versus only 11% with appropriated responses. High plasmatic follicle-stimulating hormone existed in 71% of the no response group. Detryptoréline, a luteinizing hormone-releasing hormone agonist associated with menotropins, in a "short procedure" maintained the adequate responses and suppressed premature LH surges. The no response group was moderately improved, as were multifollicular and dissociated cystic response groups. Hormonal profiles could be useful predictive factors of the ovarian response for adaptation on the first procedure of stimulation.
Fénichel
P
P
Department of Endocrinology and Diabetology, Hôpital de l'Archet, Nice, France.
Grimaldi
M
M
Olivero
J F
JF
Donzeau
M
M
Gillet
J Y
JY
Harter
M
M
D000328:Adult; D000728:Androgens / Q000097:blood; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D013268:Stimulation, Chemical
D000728:Androgens; D012739:Gonadal Steroid Hormones; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone