title: Homozygosity for 8pter----q22 in acute myeloblastic leukemia with t(8;21)(q22;q22).
abstract: A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter----8q22 is reported. A t(8;21)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q- and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q22----qter. This case shows that acquired hemizygosity and homozygosity do exist in leukemia as in solid malignant tumors.
authors.affiliation: Unité INSERM U301, et L.O.I. CNRS, Hôpital Saint Louis, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Berger
mesh_terms: D002648:Child; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006720:Homozygote; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*