Relationship between changes in power spectra of electroencephalograms and arterial halothane concentration in infants.
A power spectral analysis of electroencephalograms (EEGs) was performed in 30 infants who underwent plastic surgery for cleft lip or cleft palate. The study was conducted to investigate whether there was a significant correlation between EEG changes and arterial halothane concentration in infants. The power spectral analysis of EEGs was performed by the fast Fourier transform (FFT). Arterial halothane concentration was measured with gas chromatography. The relationship between the changes in the power spectra of EEGs and the arterial halothane concentration was examined by means of a multivariate analysis. Prior to administration of halothane, two kinds of EEG patterns were discernible. In one pattern the peak of the EEG power spectra was seen in the slow wave band (slow wave group); in the other the peak of the power spectra was present in the fast wave band (fast wave group). In the occipital lead the multiple correlation coefficient and the index of determination of the slow wave group were 0.71 and 0.50, respectively, and those of the fast wave group were 0.78 and 0.61, respectively. A significant correlation was proved to be present between the normalized values of the EEG power spectra and arterial halothane concentration in the occipital lead. Therefore, the results of the present study suggest that the relationship between changes in the power spectra of EEGs in the occipital lead and arterial halothane concentration in infants can be expressed by means of multiple regression formulas.
Sugiyama
K
K
Department of Dental Anesthesiology, Osaka University Faculty of Dentistry, Japan.
Joh
S
S
Hirota
Y
Y
Kiyomitsu
Y
Y
Shibutani
T
T
Niwa
H
H
Matsuura
H
H
D000769:Anesthesia, Inhalation; D002245:Carbon Dioxide / Q000032:analysis; D002675:Child, Preschool; D002849:Chromatography, Gas; D002971:Cleft Lip / Q000601:surgery; D002972:Cleft Palate / Q000601:surgery; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D006221:Halothane / Q000097:blood*; D006801:Humans; D007223:Infant; D015999:Multivariate Analysis; D015657:Respiratory Transport; D013997:Time Factors
D002245:Carbon Dioxide; D006221:Halothane