Family study and frequency of blood group with strong B transferase accompanied by decreased A and H antigens.
Subgroups of type A blood, named A1, A2, and A1-A2 intermediate (Aint), are specifically characterized by their peculiar A alleles and have their own A1-, A2- or Aint-forms of alpha-N-acetyl-D-galactosaminyltransferase (A-transferase). It is known, however, that certain type A2B persons exhibit A1-transferase. The reason may be an unusual alpha-galactosyltransferase (B-transferase). This strong B-transferase competes with A-transferase for the substrate, H antigen, so as to decrease the A and H antigens on the red cells. We studied this blood group over three generations and found that the strong B-transferase is, in fact, inherited with the B gene and is dominant over normal B-transferase. In AB blood groups in Tokyo, the frequency of people with a strong B-transferase is 5% for A1B and 22% for A2B. This enzyme does not always cause weak H or A antigens.
Yabe
R
R
Japanese Red Cross Tokyo Metropolitan Blood Center.
Bannai
M
M
Nakata
K
K
Seno
T
T
Okubo
Y
Y
Yamaguchi
H
H
D000017:ABO Blood-Group System / Q000235:genetics*; D000372:Agglutination Tests; D004912:Erythrocytes / Q000201:enzymology*; D005700:Galactosyltransferases / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010375:Pedigree; D013997:Time Factors
D000017:ABO Blood-Group System; D005700:Galactosyltransferases