title: Clinical studies of ifosfamide/mesna at St Jude Children's Research Hospital, 1983-1988.
abstract: A phase-II study of ifosfamide with mesna, given intravenously daily for five days by bolus injection, has demonstrated the activity of ifosfamide against a spectrum of childhood malignant solid tumors. Ifosfamide presently is being investigated in alternative phase-I schedules, daily times three or every other day times three with the aim of delivering comparable amounts of ifosfamide without increasing toxicity--specifically, neurotoxicity. Additionally, response following ifosfamide treatment is being evaluated for previously untreated children with osteosarcoma and rhabdomyosarcoma after 6 weeks of treatment, and for previously untreated patients with Ewing's sarcoma after 9 weeks of treatment with ifosfamide/VP-16 (etoposide) given in combination.
authors.affiliation: Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN 38101.
authors.forename: C B
authors.initials: CB
authors.lastname: Pratt
authors.forename: E C
authors.initials: EC
authors.lastname: Douglass
authors.forename: E
authors.initials: E
authors.lastname: Etcubanas
authors.forename: M P
authors.initials: MP
authors.lastname: Goren
authors.forename: A A
authors.initials: AA
authors.lastname: Green
authors.forename: F A
authors.initials: FA
authors.lastname: Hayes
authors.forename: M E
authors.initials: ME
authors.lastname: Horowitz
authors.forename: W H
authors.initials: WH
authors.lastname: Meyer
authors.forename: E I
authors.initials: EI
authors.lastname: Thompson
authors.forename: J A
authors.initials: JA
authors.lastname: Wilimas
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy*; D012074:Remission Induction; D012509:Sarcoma / Q000188:drug therapy
chemical_list: D008623:Mercaptoethanol; D015080:Mesna; D007069:Ifosfamide