title: Antileukemic effect of low-dose harringtonine.
abstract: The effect of harringtonine (HA) in various concentrations on HL-60 was evaluated. 0.10 microgram/ml HA showed a strong cell killing effect, and 0.025 microgram/ml HA a weak differentiation induction accompanied by cell growth retardation. Differentiation induction did not occur in 5 other human leukemic cell lines. We consider that antileukemic effect of HA is cytotoxicity, not differentiation induction.
authors.forename: S S
authors.initials: SS
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: J Y
authors.initials: JY
authors.lastname: Fu
authors.forename: L L
authors.initials: LL
authors.lastname: Chen
authors.forename: F S
authors.initials: FS
authors.lastname: Zhao
authors.forename: F X
authors.initials: FX
authors.lastname: Shan
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D006248:Harringtonines / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D006248:Harringtonines