hCG-treatment alone is insufficient for restitution of spermatogenesis in a state with arrest at the spermatogonial level.
In an infertile man with azoospermia and arrest at the spermatogonial stage, hCG treatment alone improved the spermatogenesis but not beyond the primary spermatocyte stage. During hCG treatment steroid conversion in vitro in testicular biopsy material, as well as serum testosterone concentrations increased dramatically. When hMG treatment was added, spermatogenesis was complete. Combined hCG/hMG treatment seems to be an efficient therapy in well-selected infertile men, whereas increased testosterone production induced by hCG-treatment may be insufficient for restitution of spermatogenesis.
Hammar
M
M
Department of Obstetrics and Gynaecology, University Hospital of Linköping, Sweden.
Berg
A A
AA
Kjessler
B
B
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D009845:Oligospermia / Q000188:drug therapy*; D013091:Spermatogenesis / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis
D006063:Chorionic Gonadotropin; D013739:Testosterone; D008596:Menotropins