Biological studies on 1,2-benzisothiazole derivatives. I. Evaluation of antibacterial, antifungal and DNA-damaging activity.
The in vitro evaluation of antibacterial, antifungal and DNA-damaging properties of some 1,2-benzisothiazole compounds is described. Among all the tested compounds, XXX exhibited the highest antimicrobial activity. A selective antibacterial or antifungal activity was observed for compounds XXI, XXXI and XXXVI. Some of the compounds tested, turned out to have genotoxic properties.
Vicini
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Istituto di Chimica Farmaceutica e Tossicologica, Università di Parma, Italy.
Mazza
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D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004249:DNA Damage; D009153:Mutagens / Q000138:chemical synthesis; D011995:Recombination, Genetic / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009153:Mutagens; D013844:Thiazoles