[Anti-carcinogenic and anti-blastic effect of vitamin A in various modes of its administration to random-bred rats during carcinogenesis of the mammary gland, induced by 7,12-dimethylbenz(a)anthracene].
The dependence of the anticarcinogenic and antiblastic effect of retinoid on the regime of its inoculation and on the process stage has been established using the 7,12 dimethylbenz(a)anthracene-induced mammary carcinogenesis of rats. The prophylactic administration of retinoid alone and its therapeutic inoculation against a background of hormonal correction resulted in the most expressed effect that was estimated by the elongation of the latent period, incidence and growth rate of tumours, lifespan of treated animals as well as by the distribution of malignant and benign tumours.
Piatchanina
T V
TV
Kartavova
N S
NS
Gutnik
N S
NS
Sidorik
E P
EP
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004333:Drug Administration Routes; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene
Antikantserogennoe i antiblasticheskoe deĭstvie vitamina A pri razlichenykh rezhimakh ego vvedeniia nelineĭnym krisam v period kantserogeneza molochnoĭ zhelezy, indutsirovannogo 7,12-dimetil- benz(a)antratsenom.