Severe renal failure following high-dose ifosfamide and mesna.
A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.
Willemse
P H
PH
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
de Jong
P E
PE
Elema
J D
JD
Mulder
N H
NH
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology
D008623:Mercaptoethanol; D015080:Mesna; D007069:Ifosfamide