Conformations of peptides containing Z-alpha,beta-dehydroleucine (delta ZLeu). A comparison of Boc-Pro-delta ZLeu-Gly-NHEt and Boc-Pro-delta ZPhe-Gly-NHEt.
Two tripeptides of the type Boc-Pro-delta ZX-Gly-NHEt (where X = Leu, Phe) have been synthesized and their solution conformations investigated by 270 MHz 1H n.m.r. and i.r. spectroscopy. These conformational studies indicated that delta ZLeu, similar to delta ZPhe, has a strong tendency to stabilize folded Type II beta-turn conformations when present at i + 2 position.
Uma
K
K
Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
Balaram
P
P
Kaur
P
P
Sharma
A K
AK
Chauhan
V S
VS
D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared
D009842:Oligopeptides; C068539:dehydroleucine; C068540:tert-butyloxycarbonyl-prolyl-dehydroleucyl-glycyl-ethylamide; C068541:tert-butyloxycarbonyl-prolyl-dehydrophenylalanyl-glycyl-ethylamide; D007930:Leucine