Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries.
The aim of the present investigation was to compare the activity of RGH-2981 and two reference compounds, verapamil and LY 53857 on isolated, normal animal and pathological human arteries. The majority of the latter displayed vasoconstriction against 5-HT, or KCl, what evidences that despite serious vascular damage they did not develop a total functional failure. RGH-2981 showed a moderate serotonin and Ca++ antagonistic activity in both normal rabbit and pathological human arteries.
Szombathelyi
Z
Z
Chemical Works of G. Richter, Pharmacological Research Centre, Budapest, Hungary.
Kárpáti
E
E
Till
A
A
D000328:Adult; D000368:Aged; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D004873:Ergolines / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011807:Quinolizines / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D014652:Vascular Diseases / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D004873:Ergolines; D007211:Indoles; D010975:Platelet Aggregation Inhibitors; D011807:Quinolizines; D014665:Vasodilator Agents; D012701:Serotonin; D011189:Potassium Chloride; D014700:Verapamil; C066359:vintoperol; C032663:LY 53857