[Expression of the class II antigens of the major histocompatibility complex on the blood cells of psoriasis patients and its alteration under the influence of interferon preparations].
The immune status, the level of expression of class II HLA histocompatibility antigens in the peripheral blood cells, and the effects on this antigen expression of alpha- and gamma-interferons have been examined in 21 patients with psoriatic arthropathy. Examinations of the immune status have revealed reduced levels of T-lymphocytes, of active E-RFC, of cells forming rosettes with autologous red cells, and an increased count of 0-lymphocytes. The level of class II antigen expression in monocytes, in total lymphocyte population, and in the fraction enriched for B-lymphocytes is much reduced in all the patients suffering from psoriatic arthropathy. The level of these antigens' expression in T-lymphocytes is increased in 2/3 of patients and unchanged in the rest. Intranasal alpha-interferon increased class II antigen expression in the peripheral blood monocytes of patients, whereas gamma-interferon induced no such effect. The stimulating effect of alpha-interferon on the patients' monocytes has been much less manifest than on normal donor monocytes. The antigen expression in the patients' blood lymphocytes exposed to alpha- and gamma-interferons has been virtually the same.
Medunitsyn
N V
NV
Avdeeva
Zh I
ZhI
Mazina
N M
NM
Krylov
O R
OR
Lukasheva
T V
TV
D000328:Adult; D001168:Arthritis / Q000276:immunology* / Q000628:therapy; D004341:Drug Evaluation; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology* / Q000628:therapy
D000949:Histocompatibility Antigens Class II; D007370:Interferon Type I; D007371:Interferon-gamma
Ekspressiia antigenov glavnogo kompleksa gistosovmestimosti II klassa na kletkakh krovi bol'nykh psoriazom i ee izmenenie pod vliianiem preparatov interferonov.