[The effect of moderate surgical aggression on the immune system. The usefulness of the Multitest as a method for studying immune activity].
With the aim of studying the effect of moderate surgical aggression on the immunity system, a group of 22 patients was selected, who were not affected by immuno-depressive factors apart from the surgery itself. Changes in the nutritional state of these patients were analyzed using anthropometric, biochemical and immunity procedures, with regard to levels of immunoglobulin, complement and lymphocytic populations at different times during the first 30 postoperative days. Alterations were observed both in humoral and cellular immunity in the sense of temporary immunodepression. These changes were not reflected in the skin reaction tests to antigens in the Multitest (R). The origin and significance of postsurgical immunodepression was discussed, as well as the need for developing investigation models, both clinical and in the laboratory, in order to shed some light on the dilemma of the physiopathology of the immunity system in surgical patients.
Alcaraz Lorente
P
P
Pardo García
J L
JL
Villamor Rodríguez
J A
JA
Alvarez López
M R
MR
García Alonso
A
A
Parrilla Paricio
P
P
Canteras Jordana
M
M
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007111:Immunity, Cellular; D007159:Immunologic Tests; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000276:immunology; D011183:Postoperative Complications / Q000276:immunology; D013514:Surgical Procedures, Operative
Efecto de la agresión quirúrgica moderada sobre el sistema inmunitario. Utilidad del Multitest como método de estudio de la actividad inmune.