title: Lymphocyte infiltration into cerebellum in transgenic mice carrying human IL-2 gene.
abstract: We created transgenic mice with an intact human genomic interleukin-2 gene (gIL-2) or a mouse metallothionein-I promoter-human IL-2 chimeric gene (MTgIL-2). Nine (2 gIL-2 and 7 MTgIL-2 transgenics) out of 12 transgenic mice which were obtained independently had motor ataxic symptoms. All transgenic offspring of the symptomatic founders showed the same symptoms as their transgenic parents. Morphological examination demonstrated perivascular lymphocyte accumulation in the cerebellar meninx which was followed by increased cell infiltration of neutrophils and monocytes in the destructive cerebellum of all transgenic mice. These findings suggest that the lymphocyte infiltration in the cerebellum is caused by the specific effect of the exogenously introduced human IL-2 gene.
authors.affiliation: Department of DNA Biology, School of Medicine, Tokai University, Isehara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katsuki
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Otani
authors.forename: O
authors.initials: O
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Nozawa-Kimura
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: S
authors.initials: S
authors.lastname: Habu
mesh_terms: D000818:Animals; D001483:Base Sequence; D002524:Cerebellar Ataxia / Q000235:genetics / Q000473:pathology; D002531:Cerebellum / Q000473:pathology*; D004247:DNA / Q000235:genetics; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics* / Q000502:physiology; D008214:Lymphocytes / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data
chemical_list: D007376:Interleukin-2; D004247:DNA