Two epithelioid malignant schwannomas in a patient with neurofibromatosis. Cytology, histology and DNA-flow-cytometry.
Cytological, histological and DNA-ploidy findings of 2 epithelioid malignant schwannomas arising in a patient with von Recklinghausen's neurofibromatosis are described. In both primary tumors, i.e. in the thigh and in the thoracic wall, origin from a neurofibromatous nerve could be established. Within 2 years after the manifestation of the first malignant tumor the patient died of widely metastasized disease. DNA-flow cytometry of several neurofibromas revealed diploid stemlines, but both malignant primary tumors and a lung metastasis appeared to be aneuploid. Presumably, the primary tumors also contained cell populations with a diploid stem line.
Molenaar
W M
WM
Dept. of Pathology, University of Groningen, The Netherlands.
Ladde
B E
BE
Schraffordt Koops
H
H
Dam-Meiring
A
A
D000328:Adult; D004247:DNA / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D007367:Intercostal Nerves; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009423:Nervous System Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009442:Neurilemmoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications*; D010524:Peripheral Nervous System Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D013848:Thigh; D013900:Thoracic Nerves; D013909:Thorax
D009418:S100 Proteins; D004247:DNA