title: [Rhesus antagonism, sometimes different from usual].
abstract: We describe three children with an active rhesus antagonism. However, laboratory results and course were different than usual. The first child had blood-type O positive, while his mother had blood-type O positive as well. The mother of the second child had blood-type A negative, while the child seemed to be A negative too. The third child needed an exchange transfusion due to a 'regular' rhesus antagonism, but died shortly after. The mother of the first child turned out to have a rhesus D VI variant. The second child had a 'blocked' D-antigen due to excess anti-D antibodies. The illness of the third child looked like Graft versus Host disease clinically, but eventually appeared to have congenital myelofibrosis. A correct diagnosis in these children is of great importance in future pregnancies, blood transfusions and genetic counseling.
authors.affiliation: St. Clara Ziekenhuis, Rotterdam.
authors.forename: R
authors.initials: R
authors.lastname: Rodrigues Pereira
authors.forename: M G
authors.initials: MG
authors.lastname: Van Wilgenburg
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D004899:Erythroblastosis, Fetal / Q000150:complications / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis / Q000235:genetics; D008297:Male; D010375:Pedigree; D055728:Primary Myelofibrosis / Q000150:complications; D012203:Rh Isoimmunization / Q000276:immunology*
chemical_list: D007518:Isoantibodies
vernacular_title: Rhesus-antagonisme, soms anders dan gebruikelijk.