Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1.
Neopterin, a biochemical marker for the activation of cell-mediated immune reactions, was determined in serum and cerebrospinal fluid (CSF) from patients infected with HIV-1. A significant correlation was found between serum and CSF neopterin concentrations, although concentrations of neopterin in serum were more closely correlated with the clinical severity of HIV-1 infection than those in CSF. However, higher CSF levels were observed in patients with neurologic/psychiatric symptoms than in unaffected patients. Also, quotients of CSF neopterin versus serum neopterin concentrations were increased, indicating intrathecal production of neopterin. Positive HIV-1 isolation from peripheral blood mononuclear cells (PBMC) was associated with higher neopterin concentrations in serum, when compared with negative HIV-1 isolation. Neopterin in CSF appears to be a suitable biochemical marker in patients with HIV-1 infection for detecting overt neurologic/psychiatric disturbances. The data suggest that in HIV-1 infected patients, cell-mediated immune reactions might be activated intrathecally and might contribute to neuropsychiatric disease.
Fuchs
D
D
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Chiodi
F
F
Albert
J
J
Asjö
B
B
Hagberg
L
L
Hausen
A
A
Norkrans
G
G
Reibnegger
G
G
Werner
E R
ER
Wachter
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D000328:Adult; D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology
D001708:Biopterins; D019798:Neopterin