Effects of ischemia-reperfusion injury on microvascular permeability in skeletal muscle.
Microvascular permeability changes (using FITC-dextran 150 clearance as an index) produced by ischemia-reperfusion (I-R) were investigated in the rat cremaster muscle. I-R produced significant sustained increases in microvascular permeability to macromolecules. Pretreatment with dexamethasone and verapamil reduced this I-R effect. Leukopenia also afforded protection to the microcirculation. It was concluded that changes occurring during ischemia are major causative components of the ischemia-reperfusion damage.
Durán
W N
WN
Department of Physiology, UMDNJ-New Jersey Medical School 07103-2757.
Dillon
P K
PK
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D003911:Dextrans / Q000378:metabolism; D003956:Dialysis; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives*; D005452:Fluoresceins / Q000378:metabolism; D007511:Ischemia / Q000503:physiopathology; D007970:Leukopenia / Q000503:physiopathology; D008297:Male; D008833:Microcirculation; D009132:Muscles / Q000098:blood supply* / Q000473:pathology; D051381:Rats; D011920:Rats, Inbred WF; D015427:Reperfusion Injury / Q000503:physiopathology*; D014700:Verapamil / Q000494:pharmacology
D003911:Dextrans; D005452:Fluoresceins; C015219:fluorescein isothiocyanate dextran; D003907:Dexamethasone; D014700:Verapamil; D016650:Fluorescein-5-isothiocyanate