title: Spontaneous mutation results in loss of the cytadhesin (P1) of Mycoplasma pneumoniae.
abstract: The cytadhesin (P1) structural gene of a spontaneous mutant of Mycoplasma pneumoniae which displayed a P1-negative phenotype was analyzed. An extra adenine was discovered in a stretch of normally seven adenines near the N-terminal region of the mutant P1 structural gene. The frameshift mutation resulted in the early termination of protein translation. Possible causes of the mutation are discussed.
authors.affiliation: Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758.
authors.forename: C J
authors.initials: CJ
authors.lastname: Su
authors.forename: A
authors.initials: A
authors.lastname: Chavoya
authors.forename: J B
authors.initials: JB
authors.lastname: Baseman
mesh_terms: D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics* / Q000302:isolation & purification; D001483:Base Sequence; D005796:Genes; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000235:genetics*
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C035471:adhesin, Mycoplasma pneumoniae