Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays.
Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G1 resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (approximately 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G0.
Moquet
J E
JE
National Radiological Protection Board, Didcot, Oxon, Great Britain.
Prosser
J S
JS
Edwards
A A
AA
Lloyd
D C
DC
D000222:Adaptation, Physiological; D002453:Cell Cycle; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000528:radiation effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects*; D014965:X-Rays
D008937:Mitomycins; D016685:Mitomycin