title: Bacterial chemistry-III: preliminary studies on trypanosomal activities of Chromobacterium violaceum products.
abstract: It has been found that the pigment-I from Chromobacterium violaceum, 3-[1,2-dihydro5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-yli diene] 1,3-dihydro-2H-indol-2-one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 microM after 48 h of interaction with a total growth inhibition in the same period. Pigment-I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound.
authors.affiliation: Biological Chemistry Laboratory, Universidade Estadual de Campinas, SP, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Durán
authors.forename: V
authors.initials: V
authors.lastname: Campos
authors.forename: R
authors.initials: R
authors.lastname: Riveros
authors.forename: A
authors.initials: A
authors.lastname: Joyas
authors.forename: M F
authors.initials: MF
authors.lastname: Pereira
authors.forename: M
authors.initials: M
authors.lastname: Haun
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D002861:Chromobacterium / Q000378:metabolism*; D006224:Cricetinae; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D014344:Trypanocidal Agents