title: Increased extracellular secretion in fragile mutants of Saccharomyces cerevisiae.
abstract: Evidences are presented for a generally increased extracellular secretion capability of the fragile mutants of S. cerevisiae. Proteins secreted in wild type yeasts to the periplasmic space can not be retained by the defective cell wall of the fragile cells and are released into the medium. Changes in the structure of non-mannan components of the cell wall might be the reason for the extracellular release of the periplasmic proteins.
authors.affiliation: Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
authors.forename: L
authors.initials: L
authors.lastname: Waltschewa
authors.forename: D
authors.initials: D
authors.lastname: Philipova
authors.forename: P
authors.initials: P
authors.lastname: Venkov
mesh_terms: D000135:Acid Phosphatase / Q000096:biosynthesis; D000596:Amino Acids / Q000378:metabolism; D001119:Arginase / Q000096:biosynthesis; D002473:Cell Wall / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000235:genetics; D043326:Glucan 1,3-beta-Glucosidase; D006026:Glycoside Hydrolases / Q000096:biosynthesis; D008245:Lysophospholipase / Q000096:biosynthesis; D009154:Mutation; D010455:Peptides / Q000378:metabolism; D010957:Plasmids; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D043324:beta-Fructofuranosidase; D001617:beta-Glucosidase / Q000096:biosynthesis
chemical_list: D000596:Amino Acids; D005656:Fungal Proteins; D010455:Peptides; D008245:Lysophospholipase; D000135:Acid Phosphatase; D006026:Glycoside Hydrolases; D001617:beta-Glucosidase; D043324:beta-Fructofuranosidase; D043326:Glucan 1,3-beta-Glucosidase; D001119:Arginase