[Vasoconstrictor contained in local anesthetic--its effect on body temperature and circulatory kinetics].
Changes in body temperature and blood circulation wave been monitored to investigate the effect of some vasoconstrictor contained in a local anesthetic on living body. The results obtained are described below. Subjects selected were six healthy male students (23-29 years in age). Drugs used for the experiment were 3% tolycaine for local anesthetic added with 72 micrograms, 108 micrograms or 144 micrograms of epinephrine in epinephrine group; with 90 micrograms, 135 micrograms or 180 micrograms of norepinephrine in norepinephrine group, and with each 36 micrograms, 54 micrograms, 72 micrograms of epinephrine and 36 micrograms, 54 micrograms or 72 micrograms of norepinephrine in epinephrien + norepinephrine group. 1. Change in body temperature 1) Tympanic membrane temperature There was no significant difference between pre- and post injection values in all dose groups. 2) Average skin temperature in big toe The temperature was decreased significantly at 0-25 min. in epinephrine group, in norepinephrine group and in epinephrine + norepinephrine group, compared to that prior to injection. 2. Change in circulatory kinetics 1) Epinephrine group Heart rate and RPP was increased significantly at 0-40 min. (72 micrograms) and at 0-50 min. (108 micrograms and 144 micrograms) in epinephrine group. 2) Norepinephrine group In norepinephrine 90 micrograms group, blood pressure showed a significantly high level at 5-25 min. in systolic pressure and at 0-25 min. in diastolic pressure, compared to those prior to injection. In norepinephrine 135 micrograms group, blood pressure showed a significantly high level at 0-25 min. in systolic pressure and at 0-30 min. in diastolic pressure, compared to those prior to injection. In norepinephrine 180 micrograms group, blood pressure showed a significantly high level at 0-30 min. in systolic pressure and at 0-20 min. in diastolic pressure, compared to those prior to injection. MAP was significantly high level in mean artereial pressure of norepinephrine group at 0-20 min. compared to that prior to injection. Heart rate was increased significantly at 5-30 min. in norepinephrine 90 micrograms group, decreased significantly at 0-30 min. in norepinephrine 135 micrograms group, and decreased significantly at 0-20 min. in norepinephrine 180 micrograms group, compared to those prior to infection. RPP showed a low level at 5-20 min. in norepinephrine 90 micrograms group, at 10-15 min. in norepinephrine 135 micrograms group, and at 10 min. in norepinephrine 180 micrograms group, both being of significance when compared to those prior to injection.(ABSTRACT TRUNCATED AT 400 WORDS)
Yoshii
H
H
D000328:Adult; D000779:Anesthetics, Local / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*
D000779:Anesthetics, Local; D009638:Norepinephrine; D004837:Epinephrine