[Serum acute phase proteins in nasopharyngeal carcinoma and laryngeal cancers].
Serum levels of three acute phase proteins (APPs)alpha 1-antitrypsin (alpha 1-AT), alpha 1-acid glycoprotein (alpha 1-AGP), Haptoglobin (HP), and prealbumin (PA) and cancer serum index (CSI, alpha 1-AGP/PA) were measured in 106 nasopharyngeal carcinoma 57 laryngeal cancer patients; 60 healthy adults and 52 patients with chronic inflammation of the nasopharynx or larynx served as controls. In the nasopharyngeal carcinoma group, mean serum levels of APPs and CSI were significantly elevated in patients with stage III or IV cancers than those with stage I or II cancers prior to treatment and normal controls or patients with chronic inflammation; serum concentration of PA was lowered, but that of APPs and CSI elevated in patients with recurrences as compared with tumor-free patients after treatment. In the laryngeal cancer group, serum levels of APPs and CSI were significantly higher in patients with stage IV cancers than those with stage I-II or III cancers prior to treatment, and the levels of alpha 1-AT and HP elevated in patients with stage III as compared with those with stage I-II cancers. No comparison was made between laryngeal cancer patients with recurrences and tumor-free patients, because there were only 2 cases with recurrences in our hospital. There were no difference in all measured values between patients with laryngeal and nasopharyngeal disorders. The above results suggest that measurements of APPs, PA, and CSI may be useful indicators in deciding metastasis or recurrence of nasopharyngeal and laryngeal cancers.
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D000209:Acute-Phase Proteins / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood*; D009303:Nasopharyngeal Neoplasms / Q000097:blood*; D009961:Orosomucoid / Q000032:analysis; D011228:Prealbumin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D011228:Prealbumin; D000515:alpha 1-Antitrypsin