title: Unilateral temporal lobe lesions alter P300 scalp topography.
abstract: Event related potentials were recorded from patients with unilateral temporal lobe lesions and healthy volunteers. Subjects were required to silently count on infrequent target tone interspersed among presentations of a non-target tone, with an interval between tones that was relatively long and variable (6-10s). Under these task conditions, the patients were found to have P300 amplitudes that were smaller on the lesioned side relative to the non-lesioned side. This finding is interpreted as evidence that temporal lobe lesions affect the configuration of intracranial sources generating the P300 component of event-related potentials.
authors.affiliation: Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
authors.forename: J H
authors.initials: JH
authors.lastname: Daruna
authors.forename: A V
authors.initials: AV
authors.lastname: Nelson
authors.forename: J B
authors.initials: JB
authors.lastname: Green
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D012016:Reference Values; D012535:Scalp; D013702:Temporal Lobe / Q000502:physiology / Q000503:physiopathology*