Pulsatile gonadotropin secretion in pubertal children with chronic renal failure.
We have examined physiological nocturnal secretion of gonadotropins in 6 boys and 2 girls with end-stage renal disease, who had either delayed or disturbed puberty. The 5 patients treated by dialysis had reduced gonadotropin pulsatility for their stage of pubertal maturation, whereas the 3 patients with successful kidney grafts demonstrated a higher nocturnal rise and increased amplitude of gonadotropin pulsatility. It is suggested that the improved gonadotropin pulsatility of transplanted patients is due to their restored renal function.
Schaefer
F
F
Section of Endocrinology, University Children's Hospital, Heidelberg, FRG.
Stanhope
R
R
Scheil
H
H
Schönberg
D
D
Preece
M A
MA
Schärer
K
K
D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D016030:Kidney Transplantation; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011627:Puberty / Q000097:blood / Q000502:physiology*; D011628:Puberty, Delayed / Q000097:blood / Q000503:physiopathology; D006435:Renal Dialysis
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone