title: Aluminum in parenteral products: analysis, reduction, and implications for pediatric TPN.
abstract: Performance and cost of the best available analytical methodology for the measurement of aluminum in parenteral products are presented. Typical levels of aluminum in representative solutions are summarized. A methodical approach to the minimization of aluminum contamination in the manufacturing process is considered in light of aqueous aluminum chemical considerations. Results of long-term clinical follow-up studies of infants maintained on currently manufactured TPN solutions indicate no adverse pathology arising from aluminum.
authors.forename: B E
authors.initials: BE
authors.lastname: Rabinow
authors.forename: S
authors.initials: S
authors.lastname: Ericson
authors.forename: T
authors.initials: T
authors.lastname: Shelborne
mesh_terms: D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000009:adverse effects / Q000032:analysis*; D001847:Bone Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D004340:Drug Contamination / Q000032:analysis / Q000517:prevention & control; D006801:Humans; D007223:Infant; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012996:Solutions / Q000032:analysis / Q000592:standards
chemical_list: D012996:Solutions; D000535:Aluminum