Conditioned place aversion produced by FG 7142 is attenuated by haloperidol.
A place conditioning paradigm was used to examine the affective properties of FG 7142, a benzodiazepine receptor inverse agonist. At the highest dose tested (10 mg/kg, IP), FG 7142 produced a significant place aversion to the drug-paired compartment. In a second experiment, haloperidol injections were given before FG 7142. It was found that haloperidol (0.2 mg/kg) significantly reduced the measured conditioned place aversion produced by FG 7142, without exhibiting any aversive or rewarding effects by itself. These results suggest that dopamine receptors are involved in the learning or expression of conditioned place aversion induced by benzodiazepine receptor inverse agonists.
Di Scala
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Département de Neurophysiologie et Biologie des Comportements, C.N.R.S., Strasbourg, France.
Sandner
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D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D002243:Carbolines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats
D001067:Appetite Depressants; D002243:Carbolines; C035874:FG 7142; D006220:Haloperidol