title: Phagocytic multiple myeloma with disseminated intravascular coagulation.
abstract: We describe an atypical case of IgG lambda multiple myeloma in a 28-year-old patient. He developed multiple cutaneous plasmacytomas, and the terminal event, leukemic conversion by phagocytic plasma cells and disseminated intravascular coagulation. Secretion of monoclonal immunoglobulin (IgG lambda) from myeloma cells was demonstrated by plaque-forming cell assay. Electron microscopy showed myeloma cells with well-developed rough endoplasmic reticulum and erythroid cells or platelets in intracytoplasmic vacuoles.
authors.affiliation: Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: H
authors.initials: H
authors.lastname: Hata
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Takeya
authors.forename: K
authors.initials: K
authors.lastname: Takatsuki
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm