1-Deamino-8-D-arginine vasopressin lowers protein C activity in uremics.
The effect of 1-deamino-8-D-arginine vasopressin (DDAVP) on protein C was investigated in 10 uremics and 10 normal subjects. The protein C antigen was higher in the uremic patients than in the normal subjects. DDAVP had no influence on the level of protein C antigen. However, functional protein C in uremics was lower than in normals even before administration of DDAVP. Furthermore, there was a decrease in functional protein C in the uremics after administration of DDAVP. Further studies are needed to clarify the low functional protein C in uremics both before and during administration of DDAVP.
Aunsholt
N A
NA
Department of Medicine, Aalborg Hospital, Denmark.
Schmidt
E B
EB
Stoffersen
E
E
D000328:Adult; D000941:Antigens / Q000032:analysis; D001760:Bleeding Time; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D013997:Time Factors; D014511:Uremia / Q000097:blood* / Q000150:complications; D014841:von Willebrand Factor / Q000032:analysis
D000941:Antigens; D011486:Protein C; D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin