[Features of lipid peroxidation in patients with diabetes mellitus before and after therapy by a method of transplantation of human fetal islet cell cultures].
The authors discussed the results of changes in the intensity of lipid peroxidation and antioxidant activity in 70 patients with type I diabetes mellitus (severe forms) before and in 32 patients after the transplantation of human fetal pancreatic islet cell cultures. Lipid peroxidation, antioxidant activity, indices of glycolysis and carbohydrate metabolism were investigated. In some cases metabolic derangement was noted against a background of a decrease in the end products of lipid peroxidation but in a majority of diabetic patients an increase in LPO intensity was noted against a background of raised antioxidant activity, high activity of glycolytic reactions and inhibition of Krebs' cycle. The greatest effect of transplantation was noted in a group of patients who had demonstrated high levels of lactate and the lactate-pyruvate ratio before transplantation. Therefore LPO indices can serve as a criterion of the selection of patients with insulin dependent diabetes mellitus for pancreatic endocrine tissue transplantation.
Pavlovskiĭ
M P
MP
Boĭko
N I
NI
Tymochko
M F
MF
Makarenko
T N
TN
Tkachenko
O R
OR
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002952:Citric Acid Cycle; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000601:surgery; D006019:Glycolysis; D006801:Humans; D016381:Islets of Langerhans Transplantation; D015227:Lipid Peroxidation; D008297:Male; D013997:Time Factors
D000975:Antioxidants
Osobennosti perekisnogo okisleniia lipidov u bol'nykh sakharnym diabetom do i posle lecheniia metodom transplantatsii kul'tur ostrovkovykh kletok podzheludochnykh zhelez plodov cheloveka.