title: Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type I.
abstract: Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African families with neurofibromatosis type 1 (NF1). The markers--p17H8, pHHH202, and EW204--were linked to NF1 at recombination fractions less than 1%. No evidence of locus heterogeneity was detected. Inspection of recombinant events in families informative for several markers suggests that the NF1 gene is located between the markers EW301 (cen-p11.2) and EW206 (cen-q12) and possibly distal to pHHH202 (q11.2-q12).
authors.affiliation: Section of Human Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom.
authors.forename: C G
authors.initials: CG
authors.lastname: Mathew
authors.forename: K
authors.initials: K
authors.lastname: Thorpe
authors.forename: D F
authors.initials: DF
authors.lastname: Easton
authors.forename: K S
authors.initials: KS
authors.lastname: Chin
authors.forename: D
authors.initials: D
authors.lastname: Jadayel
authors.forename: M
authors.initials: M
authors.lastname: Ponder
authors.forename: G
authors.initials: G
authors.lastname: Moore
authors.forename: C E
authors.initials: CE
authors.lastname: Wallis
authors.forename: C P
authors.initials: CP
authors.lastname: Slater
authors.forename: G
authors.initials: G
authors.lastname: De Jong
mesh_terms: D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000235:genetics*; D013019:South Africa; D006113:United Kingdom
chemical_list: D005819:Genetic Markers