title: Evaluation of two enzyme immunoassays for detection of human immunodeficiency virus antigen in African and European sera.
abstract: The performance of two HIV antigen enzyme immunoassays (EIAs), the HTLV-III antigen EIA (Abbott) and the Innotest HIV antigen EIA (Innogenetics), was assessed using 276 HIV-1 antibody positive and 42 HIV antibody negative sera from European and African individuals. On the initial screening 16% (51/318) of the sera were reactive in the Abbott EIA and 21.4% (68/318) in the Innotest EIA. The Innotest detected significantly more confirmed HIV antigen positive sera (55/58, 94.6%) than the Abbott EIA (41/58, 70.7%). The presence of free detectable HIV antigen in African and European sera was strongly associated with the clinical classification CDC IV and with low p24 antibody levels.
authors.affiliation: Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Vercauteren
authors.forename: P
authors.initials: P
authors.lastname: Piot
authors.forename: M
authors.initials: M
authors.lastname: Vandenbruaene
authors.forename: G
authors.initials: G
authors.lastname: van der Groen
mesh_terms: D000349:Africa; D005060:Europe; D005069:Evaluation Studies as Topic; D005260:Female; D015488:HIV Antigens / Q000097:blood*; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male
chemical_list: D015488:HIV Antigens