Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies.
A 45-year-old man with pernicious anemia presented with sudden loss of vision due to central retinal vein thrombosis, and was found to have anticardiolipin antibodies and a clotting disorder consistent with the presence of a lupus anticoagulant. He was treated with low dose aspirin and has remained free of recurrent thrombosis over a period of one year. The association between lupus anticoagulant and pernicious anemia is rare, having been reported in only one prior case.
Heckerling
P S
PS
Department of Medicine, University of Illinois, Chicago 60680.
Froelich
C J
CJ
Schade
S G
SG
D000752:Anemia, Pernicious / Q000150:complications* / Q000276:immunology; D001241:Aspirin / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology*; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications / Q000276:immunology; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D014805:Vitamin B 12 / Q000627:therapeutic use
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D014805:Vitamin B 12; D001241:Aspirin