In vitro activity of lomefloxacin against Chlamydia trachomatis, Neisseria gonorrhoeae, Haemophilus ducreyi, Mycoplasma hominis, and Ureaplasma urealyticum.
The in vitro activity of lomefloxacin, a new difluorinated quinolone antimicrobial was compared to comparative agents against organisms causing sexually transmitted diseases. Against Chlamydia trachomatis, Mycoplasma hominis, Ureaplasma urealyticum, Neisseria gonorrhoeae, and Haemophilus ducreyi, lomefloxacin exhibited MIC90 of 2.0, 8.0, 8.0, less than or equal to 0.015, and 0.003 micrograms/ml, respectively. Overall, the lomefloxacin activity was very similar to ciprofloxacin.
Hoban
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D
Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada.
DeGagne
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P
Witwicki
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E
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000302:isolation & purification; D005069:Evaluation Studies as Topic; D024841:Fluoroquinolones; D006190:Haemophilus / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects / Q000302:isolation & purification; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D015363:Quinolones; D015231:Sexually Transmitted Diseases, Bacterial / Q000175:diagnosis / Q000382:microbiology; D014509:Ureaplasma
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin