Compaction stasis due to gravitational red cell migration and floatational plasma skimming. Reversal of the fahraeus effect due to pathological RCA-formation in plastic tubes and mesenteric venules.
A horizontally aimed microscope was directed at isolated rat mesentery preparations as well as artificial microchannels cast in polyester blocks. They were perfused with aggregating red cell suspensions containing about 7 g/l of bovine fibrinogen at various perfusion pressures. The effects induced by gravitational influences were monitored by measuring the local red cell concentration (video-densitometry) and velocity profiles (IPM-dual slit velocimetry). At low perfusion pressures, sedimentation during maintained flow occurs, leading to a relative red cell slowing compared with plasma. Consequently, a progressive deposition of red cells at the bottom of vessels occurs and finally, blocking of the vessel by aggregated red cells is seen. Thus, the well-known phenomenon of compaction stasis must be attributed not merely to a transmural plasma loss but also to gravitationally induced haemoconcentration.
Göbel
W
W
Department of Physiology, RWTH-Klinikum, Aachen, Federal Republic of Germany.
Perkkiö
J
J
Schmid-Schönbein
H
H
D000818:Animals; D001799:Blood Sedimentation; D002465:Cell Movement; D003720:Densitometry; D004903:Erythrocyte Aggregation / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D005340:Fibrinogen / Q000494:pharmacology; D006112:Gravitation; D006400:Hematocrit; D008642:Mesenteric Veins / Q000473:pathology / Q000503:physiopathology*; D008833:Microcirculation; D051381:Rats; D011919:Rats, Inbred Strains; D014699:Venules / Q000473:pathology / Q000503:physiopathology
D005340:Fibrinogen