title: [Recurrent infections of the urogenital tract: preliminary results of a study on the clinical and immunological effects of thymopentin treatment].
abstract: We are carrying on a trial with subcutaneous injections of thymopentin in a group of patients that presented more than 2 infectious episodes of uro-genital tract in the latest 18 months. Microbiological investigations were performed with microscopic and cultural examinations before and after six weeks of treatment with thymopentin (TP5) associated with antibiotic therapy chosen on the basis of cultural response. The follow-up was prolonged to 6 months. The immunological studies were performed at the same moments, by a panel of monoclonal antibodies and by the evaluation of the NK activity and granulocytic phagocytosis. The cellular immunity was studied by skin tests. In our patients, during the follow-up period, we observed a significant reduction of infectious episodes, an increase of NK activity, and a restoration of cellular immunity in hypoergic subjects.
authors.affiliation: Università degli Studi La Sapienza, Roma, Istituto di Clinica Medica III.
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.forename: R
authors.initials: R
authors.lastname: Di Rosa
authors.forename: G M
authors.initials: GM
authors.lastname: Ferri
authors.forename: A
authors.initials: A
authors.lastname: Afeltra
authors.forename: A
authors.initials: A
authors.lastname: Mola
authors.forename: A
authors.initials: A
authors.lastname: Pietrucci
authors.forename: L
authors.initials: L
authors.lastname: Reverberi
authors.forename: L
authors.initials: L
authors.lastname: Bonomo
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy* / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D052801:Male Urogenital Diseases; D010587:Phagocytosis / Q000187:drug effects; D012008:Recurrence; D012882:Skin Tests; D016305:Thymopentin / Q000494:pharmacology* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000276:immunology
chemical_list: D016305:Thymopentin
vernacular_title: Infezioni ricorrenti a carico dell'apparato uro-genitale: risultati preliminari di uno studio clinico ed immunologico sugli effetti del trattamento con timopentina.