Inoculation of New World primates with the human immunodeficiency virus.
The susceptibility of common marmosets and cotton-top tamarins to infection by HIV-2 in vivo was tested. One year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for HIV-2 antibodies and HIV-specific nucleotide sequences were demonstrated in short-term cultures of PBL from two cotton-top tamarins. The animals remain in good health.
McClure
M O
MO
Institute of Cancer Research, Chester Beatty Laboratories, London, England.
Schulz
T F
TF
Tedder
R S
RS
Gow
J
J
McKeating
J A
JA
Weiss
R A
RA
Baskerville
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000818:Animals; D001029:Aotus trivirgatus / Q000382:microbiology*; D015139:Blotting, Southern; D015153:Blotting, Western; D002144:Callithrix / Q000382:microbiology*; D002143:Callitrichinae / Q000382:microbiology*; D002427:Cebidae / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015483:HIV Antibodies / Q000032:analysis; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D015498:HIV-2 / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D009693:Nucleic Acid Hybridization; D012452:Saguinus / Q000382:microbiology*
D004279:DNA, Viral; D015483:HIV Antibodies