title: Balloon-occluded arterial infusion therapy in the treatment of primary and recurrent gynecologic malignancies.
abstract: Balloon-occluded arterial infusion (BOAI) of bilateral internal iliac arteries produces high drug concentration as well as increased arterial flow of pelvic organs. Twenty-seven patients with primary and locally recurrent gynecologic malignancies were treated with BOAI of cisplatinum. Six of 10 patients with primary advanced uterine cancer and 5 of 11 patients with recurrent cancer showed clinical response. In 6 patients, BOAI was performed as an adjuvant therapy to radiation or other chemotherapy. Toxicity was similar to that seen with systemic treatment using cisplatinum, but its frequency and degree were less severe.
authors.affiliation: Department of Radiology, Kumamoto University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Bussaka
authors.forename: Y
authors.initials: Y
authors.lastname: Korogi
authors.forename: R
authors.initials: R
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Fujisaki
authors.forename: H
authors.initials: H
authors.lastname: Okamura
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000188:drug therapy*; D002404:Catheterization / Q000295:instrumentation*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000098:blood supply / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
chemical_list: D002945:Cisplatin