title: [Amiodarone-induced hepatitis: biological, histological diagnosis, development and role of associated factors. Review of the literature. Report of 2 cases].
abstract: Two cases of pseudo-alcoholic amiodarone-induced hepatitis are reported. The authors mention the different clinical forms of the disease and describe its clinical, biochemical and histological features. They stress the unpredictable and discordant character of its course and the influence of associated pathological factors. The role played by Ito's cells in the genesis of the liver fibrosis observed in amiodarone toxicity is discussed.
authors.affiliation: Service de médecine A, hôpital Saint-Nicolas, Verdun.
authors.forename: J F
authors.initials: JF
authors.lastname: Roche
authors.forename: P
authors.initials: P
authors.lastname: Netter
authors.forename: G
authors.initials: G
authors.lastname: Gay
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008099:Liver / Q000737:chemistry; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism; D012307:Risk Factors
chemical_list: D010743:Phospholipids; D000638:Amiodarone
vernacular_title: Hépatites à l'amiodarone: diagnostic biologique, histologique, évolution et rôle des facteurs associés. Revue de la littérature. A propos de deux observations.