Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src.
We isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells. p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein.
Bedard
P A
PA
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
Yannoni
Y
Y
Simmons
D L
DL
Erikson
R L
RL
D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005786:Gene Expression Regulation; D007328:Insulin / Q000494:pharmacology*; D007399:Interphase; D054834:Lipocalins; D008969:Molecular Sequence Data; D015688:Oncogene Protein pp60(v-src); D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012191:Retroviridae Proteins / Q000494:pharmacology*
D030161:Avian Proteins; D001798:Blood Proteins; D007328:Insulin; D054834:Lipocalins; D012333:RNA, Messenger; D012191:Retroviridae Proteins; D004815:Epidermal Growth Factor; D004247:DNA; D015688:Oncogene Protein pp60(v-src)