title: Treatment of gonococcal conjunctivitis with single-dose intramuscular ceftriaxone.
abstract: We treated 13 consecutive patients with culture proven Neisseria gonorrhoeae conjunctivitis with single-dose intramuscular injections of ceftriaxone. Pretreatment conjunctival cultures and Gram stains were obtained from all patients. The patients were admitted for antibiotic administration, a single conjunctival saline lavage, and follow-up conjunctival cultures six and 12 hours after treatment. Three of 13 organisms (23%) were penicillinase producing. All patients responded to treatment, and all six- and 12-hour posttreatment cultures were negative for N. gonorrhoeae. These results indicate that a single intramuscular dose of ceftriaxone is curative treatment for non-neonatal gonococcal conjunctivitis.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33010.
authors.forename: R
authors.initials: R
authors.lastname: Haimovici
authors.forename: T J
authors.initials: TJ
authors.lastname: Roussel
mesh_terms: D000293:Adolescent; D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000382:microbiology; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D004341:Drug Evaluation; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D002443:Ceftriaxone