The immunomodulatory effects of interferon-gamma on mature B-lymphocyte responses.
Interferon-gamma (IFN-gamma) exerts a broad spectrum of activities which affect the responses of mature B-cells. It strongly inhibits B-cell activation, acts as a B-cell growth factor (BCGF), and also induces final differentiation to immunoglobulin (Ig) production. IFN-gamma is deeply involved in the differential control of isotype expression, as it enhances IgG2a production and suppresses both IgG1 and IgE production. Although it is now possible to draw a general scheme of the effects of IFN-gamma on B-cells, a number of paradoxical results still exist in the field. In this manuscript, different experimental systems are analyzed in an attempt to explain these apparent paradoxes.
Jurado
A
A
Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada.
Carballido
J
J
Griffel
H
H
Hochkeppel
H K
HK
Wetzel
G D
GD
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000378:metabolism; D007371:Interferon-gamma / Q000502:physiology*; D015847:Interleukin-4; D007378:Interleukins
D007074:Immunoglobulin G; D007378:Interleukins; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma