title: Diabetic ketoacidosis.
abstract: The classic presentation of DKA, consisting of hyperglycemia, anion gap acidosis, and ketonuria, is readily recognized. The diagnosis may be missed, however, in the patient who is euglycemic, has a negative nitroprusside test for ketones, or has a nonanion gap metabolic acidosis. Treatment includes replacement of fluid and electrolytes lost through osmotic diuresis. Failure to recognize the magnitude of total-body potassium depletion and to begin replacement despite an initially normal serum potassium level may lead to fatal cardiac arrhythmia. Serum glucose must be monitored closely to avoid hypoglycemia; dextrose should be added to the infusion once the serum glucose falls to 250 mg per dl. Insulin is required to reverse ketoacid production by the liver; low-dose therapy is recommended. Ketogenesis may be reversed inadequately unless insulin treatment is continued until the anion gap has normalized. Failure to recognize precipitating causes may result in increased morbidity and mortality from underlying infection or myocardial infarction as well as rapid relapse of ketoacidosis.
authors.affiliation: Department of Emergency Medicine, Wilford Hall USAF Medical Center, San Antonio, Texas.
authors.forename: R S
authors.initials: RS
authors.lastname: Israel
mesh_terms: D016883:Diabetic Ketoacidosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D004630:Emergencies; D006801:Humans