title: Primary duodenal carcinoma arising in a non-vaterian tubulo-villous adenoma. A case report with immunocytochemical analysis and review of the literature.
abstract: Primary duodenal carcinoma and duodenal adenoma are rare tumours. Duodenal carcinoma makes up about 0.3% of all malignant tumours of the gastrointestinal tract (Alwmark et al. 1980; Spira et al. 1977). The present paper describes a duodenal carcinoma arising in a mixed tubulo-villous non-Vaterian adenoma in a 68 year old male. Immunocytochemical analysis revealed evidence of neuroendocrine differentiation in both adenoma and carcinoma. In a review of the literature a correlation between the size of adenoma and the probability of concomitant carcinoma is demonstrated. Duodenal adenoma measuring more than 4 cm in diameter should be considered potentially malignant.
authors.affiliation: Department of Pathology, University of Basel, Switzerland.
authors.forename: H R
authors.initials: HR
authors.lastname: Zenklusen
authors.forename: J
authors.initials: J
authors.lastname: Landmann
authors.forename: A
authors.initials: A
authors.lastname: Feess
authors.forename: M
authors.initials: M
authors.lastname: Dürig
authors.forename: M
authors.initials: M
authors.lastname: Kasper
authors.forename: M
authors.initials: M
authors.lastname: Oberholzer
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000556:secondary; D000368:Aged; D000911:Antibodies, Monoclonal / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D004379:Duodenal Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008223:Lymphoma / Q000473:pathology / Q000556:secondary; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009490:Neurosecretory Systems / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin
chemical_list: D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D053379:Chromogranin A; D002864:Chromogranins; D008565:Membrane Proteins; D016708:Synaptophysin