Complex partial status epilepticus associated with cyclosporin A therapy.
Significant neurotoxicity including seizures, encephalopathy and coma may complicate the use of cyclosporin A (CyA). Two patients are described, receiving CyA, who presented with abnormal behaviour, stupor, focal motor activity and were shown to be in complex partial status epilepticus (CPSE). Abnormalities of behaviour and/or stupor in patients receiving CyA may be a manifestation of CPSE. Patients receiving CyA who develop an encephalopathy should have electroencephalography performed at the time of the abnormal behaviour.
Appleton
R E
RE
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Farrell
K
K
Teal
P
P
Hashimoto
S A
SA
Wong
P K
PK
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male
D003524:Cyclosporins