The endogenous pyrogens in host-defense interactions.
Soluble factors produced by activated macrophages serve to marshal host defenses against infection, injury, or inflammation, but they may also cause chronic inflammation or even lethal shock. Suppressing or enhancing such cytokine functions has important therapeutic potential in, respectively, chronic inflammatory and immunologically deficient states.
Dinarello
C A
CA
Tufts University School of Medicine, Boston.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D005334:Fever / Q000209:etiology*; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000517:prevention & control; D007249:Inflammation / Q000188:drug therapy* / Q000517:prevention & control; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000097:blood / Q000502:physiology; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000032:analysis; D008262:Macrophage Activation / Q000502:physiology; D011749:Pyrogens / Q000096:biosynthesis*; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000502:physiology
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D007375:Interleukin-1; D015850:Interleukin-6; D011749:Pyrogens; D014409:Tumor Necrosis Factor-alpha; C008270:leukocyte endogenous mediator