Galanin: hydrokinetic action on salivary glands in man.
Galanin was infused intravenously into eight healthy volunteers at a dose of 40 pmol kg-1 min-1 for 1 h to investigate the pharmacological effects of this peptide on the postprandial sialagogical response in man. Galanin significantly increased the salivary volume and the saliva output of sodium, chloride and bicarbonate compared to control saline infusion, but had no effect on the output of potassium and alpha-amylase. An increase in salivary pH was also observed. The increase in salivary volume may indicate a physiological role of galanin in the control of salivary secretion.
Bauer
F E
FE
Department of Clinical Pharmacology, Georg-August-Universität Göttingen, FRG.
Ghatei
M A
MA
Zintel
A
A
Bloom
S R
SR
D000328:Adult; D004435:Eating / Q000502:physiology; D005260:Female; D019004:Galanin; D006801:Humans; D008297:Male; D010455:Peptides / Q000009:adverse effects / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism*; D012472:Salivation / Q000187:drug effects*; D013649:Taste / Q000187:drug effects
D010455:Peptides; D019004:Galanin