Opioid involvement in TRH-induced antinociception in the rat following intracerebral administration.
Thyrotropin-releasing hormone (TRH) has an antinociceptive action in the rat. Antinociception was observed using a thermal stimulus (tail-flick test) after TRH administration into lateral ventricle, nucleus raphe magnus, nucleus reticularis paragigantocellularis and amygdaloid nuclei. This effect was short-lived since it was completely abolished 60 min after intracerebroventricular administration. TRH may interact with the opioid systems as its antinociceptive effect was blocked by pretreatment with naloxone.
Reny-Palasse
V
V
INSERM, Paris, France.
Monier
C
C
Rips
R
R
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004723:Endorphins / Q000378:metabolism / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D000700:Analgesics; D004723:Endorphins; D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone