Uptake and modification of dietary polyprenols and dolichols in rat liver.
Short and long dolichols and polyprenols in free form or esterified with fatty acids were incorporated into liposomes and administered to rats through a gastric tube. The free alcohols were taken up by the liver to different extents. While uptake in other organs was less, it also involved the fatty acid esters. The use of systems other than liposomes did not increase the efficiency of uptake. Most of the administered lipids were recovered in the lysosomes. Exogenous dolichols and polyprenols were both partly esterified in the liver and, to some extent, also phosphorylated; a portion of the polyprenols was also alpha-saturated. These results indicate that various polyisoprenes are taken up, to a small extent, from the diet by tissues under normal conditions and in liver these dietary lipids undergo terminal modifications.
Jakobsson
A
A
Department of Biochemistry, University of Stockholm, Sweden.
Swiezewska
E
E
Chojnacki
T
T
Dallner
G
G
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D004286:Dolichols / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D007441:Intubation, Gastrointestinal; D008081:Liposomes / Q000008:administration & dosage / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D014677:Pharmaceutical Vehicles; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004286:Dolichols; D008081:Liposomes; D014677:Pharmaceutical Vehicles; D013729:Terpenes