[An immunologic method of producing antigens for the treatment and prevention of leishmaniasis].
Antigens isolated from lysates of L. infantum promastigotes by electroelution from polyacrylamide gels and by gel filtration, have already been proven to induce anti-Leishmania protective immunity in BALB/c mice when injected subcutaneously. At the present time, five preparations including either Leishmania antigens or anti-idiotypic reagents as vaccines can be considered as candidates for immunoprophylaxis in natural hosts of Leishmania parasites. We present a new method for producing Leishmania antigenic preparations which is of considerable interest, since it can be proposed for immunotherapy and prevention of other parasitic, bacterial, viral and perhaps, retroviral diseases.
Vouldoukis
I
I
Laboratoire de Parasitologie expérimentale et I.N.S.E.R.M. U n. 313, Faculté de Médecine Pitié-Salpétrière, Paris.
Monjour
L
L
D000818:Animals; D000953:Antigens, Protozoan / Q000096:biosynthesis*; D007158:Immunologic Techniques; D007893:Leishmania donovani / Q000276:immunology; D007895:Leishmania tropica / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D014611:Vaccination
D000953:Antigens, Protozoan
Métode immunologique de production d'antigènes pour le traitement et la prévention des leishmanioses.