Aspirin-like effects of selected food additives and industrial sensitizing agents.
A number of food additives and industrial chemicals, responsible for inducing symptoms of intolerance in some individuals, have been studied in tests measuring platelet activation by noradrenaline. All the investigated agents inhibited platelet aggregation and this was associated with inhibition of the cyclo-oxygenase-thromboxane pathway. Suboptimal inhibitory concentrations of the agents studied had additive inhibitory effects on platelet aggregation when they were tested in pairs, or when tested with salicylate or aspirin. The results support the theory that some food additives and industrial chemicals induce intolerance because of their aspirin-like properties.
Williams
W R
WR
Asthma Research Unit, Sully Hospital, Cardiff, U.K.
Pawlowicz
A
A
Davies
B H
BH
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010592:Pharmaceutic Aids / Q000494:pharmacology; D010796:Phthalic Anhydrides / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013447:Sulfites / Q000494:pharmacology; D013929:Thromboxane B2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D016861:Cyclooxygenase Inhibitors; D005503:Food Additives; D010592:Pharmaceutic Aids; D010796:Phthalic Anhydrides; D010975:Platelet Aggregation Inhibitors; D013447:Sulfites; C005200:sodium metabisulfite; D013929:Thromboxane B2; D001241:Aspirin; C043103:phthalic anhydride