Imaging of rats with mammary cancer with two 2-deoxy-2-[18F]fluoro-D-hexoses.
Rats with mammary cancer were imaged by scintigraphy: 10 rats with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and 10 rats with [18F]F-D-galactose. The uptake of both tracers was similar in the tumors--the tumor-to-normal tissue ratio was 2.7 +/- 1.1 for [18F]FDG and 2.3 +/- 0.9 for [18F]FDGal at 120 min after injection. In addition to the tumors [18F]FDG accumulated in the brain, bladder and heart, [18F]FDGal in the brain, bladder and liver. [18F]FDGal may be useful for tumor imaging in man; further studies should be addressed to elucidate the mechanism of [18F]FDGal uptake into tumors.
Paul
R
R
Department of Internal Medicine, Turku University Central Hospital, Finland.
Aho
K
K
Bergman
J
J
Haaparanta
M
M
Kulmala
J
J
Reissell
A
A
Solin
O
O
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D003847:Deoxyglucose / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005643:Fucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005690:Galactose; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005643:Fucose; D015127:9,10-Dimethyl-1,2-benzanthracene; D003847:Deoxyglucose; C049289:2-deoxy-2-fluorogalactose; D005690:Galactose