[Cytogenetic instability, the ability to produce interferon and immunoreactivity of blood lymphocytes in patients with schizophrenia].
In schizophrenia patients, the level of T-lymphocytes with cytogenetic aberrations is elevated, and the ability of these cells for PGA-blast-transformation and the interferon synthesis is reduced. The elevation of the lymphocytes ability for blast-transformation in the presence of the native preparation of DNA and for lysis of the erythrocytes proper is marked in these patients. The observed changes were especially marked in schizophrenia with an interrupted course.
Il'inskikh
N N
NN
Naĭdenova
N N
NN
Vasil'eva
O A
OA
Il'inskikh
I N
IN
D002869:Chromosome Aberrations; D004260:DNA Repair; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure
D007370:Interferon Type I; D007371:Interferon-gamma
Tsitogeneticheskaia nestabil'nost', sposobnost' produtsirovat' interferon i immunoreaktivnost' limfotsitov krovi bol'nikh shizofrenieĭ.