Manganese catalyzed auto-oxidation of dopamine to 6-hydroxydopamine in vitro.
Manganese (Mn) is an essential trace element which, upon excessive exposure, produces a neurological syndrome similar to chronic Parkinson's disease in animals and humans. Previous work demonstrated that Mn was more potent than other transition metals in stimulating dopamine (DA) auto-oxidation. In these experiments, DA was incubated under physiological conditions in the presence and absence of Mn for up to 60 min. 6-Hydroxydopamine (6-OHDA) was produced in the presence of Mn, while the incubation mixture without Mn showed no DA oxidation. 6-Hydroxydopamine is a neurotoxicant which exerts its effects by destroying DA nerve terminals in the CNS. Therefore, this work suggests that the Mn catalyzed increase in DA auto-oxidation could be linked mechanistically to the appearance of Mn-induced neurotoxic effects.
Garner
C D
CD
Biomedical Science Department, General Motors Research Laboratories, Warren, MI 48090-9058.
Nachtman
J P
JP
D002712:Chlorides; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine; D006892:Hydroxydopamines; D007700:Kinetics; D008345:Manganese; D017895:Manganese Compounds; D010084:Oxidation-Reduction; D016627:Oxidopamine
D002712:Chlorides; D006892:Hydroxydopamines; D017895:Manganese Compounds; D008345:Manganese; D016627:Oxidopamine; C025340:manganese chloride; D004298:Dopamine