Comparative evaluation of acute toxicity and antitumor activity of IF-XXV preparation and holoxan.
The alkylating agent ifosfamide synthesized according to own method at the Institute of Pharmaceutical Industry, Warsaw, was compared in biological evaluations with Holoxan (Asta-Werke's ifosfamide). No significant differences between tested compounds were found in respect of acute toxicity and antitumor activity in experimental systems in mice.
Kuśnierczyk
H
H
Department of Tumor Immunology, Polish Academy of Sciences, Wrocław.
Matuszyk
J
J
Radzikowski
C
C
D000818:Animals; D005260:Female; D007069:Ifosfamide / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D007069:Ifosfamide