title: Amyloid enhancing factor (AEF) in the aging mouse.
abstract: Amyloid enhancing factor (AEF) activity was tested in spleen homogenates from 52, 28, and 9-week-old untreated mice. Strong AEF activity was present in the supernatant of spleen homogenate from the 52-week-old mice. Only weak activity was observed in the supernatant from the 28-week-old mice, and none was seen in that from the 9-week-old mice. Crude spleen homogenates from the 52-week-old mice were subjected to Sephacryl S-300 gel filtration. AEF activity existed in the first gel filtration peak. These findings suggest that AEF increases in the spleens of aged mice and that AEF may be a substance of high molecular weight.
authors.affiliation: First Department of Pathology, Yamaguchi University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Fujinaga
authors.forename: F
authors.initials: F
authors.lastname: Uchino
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002850:Chromatography, Gel; D006023:Glycoproteins / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism*; D013154:Spleen / Q000166:cytology / Q000378:metabolism
chemical_list: D006023:Glycoproteins; C046748:amyloid enhancing factor