HIV-associated endometritis.
Using immunohistochemical staining, in situ hybridization and a combination of both, we demonstrate here the replication of HIV in the endometrial stroma. Infected cells do not belong to the T-lymphocyte lineage but rather to a monocyte-macrophage cell type. This report suggests a possible relationship between HIV infection and endometritis. Moreover, HIV replication in endometrial tissues could play a role in heterosexual and materno-fetal transmission.
Peuchmaur
M
M
Service de Pathologie, Hôpital A. Béclère, Paris, France.
Emilie
D
D
Vazeux
R
R
Pons
J C
JC
Delfraissy
J F
JF
Lemaigre
G
G
Galanaud
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004716:Endometritis / Q000150:complications*; D004717:Endometrium / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006678:HIV / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008264:Macrophages / Q000382:microbiology; D009000:Monocytes / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D015347:RNA Probes; D013601:T-Lymphocytes / Q000145:classification; D014779:Virus Replication
D015347:RNA Probes