Adoptive immunotherapy of tumor in mice in combination with cyclophosphamide.
Cyclophosphamide causes temporary regression of Dalton's lymphoma when injected at palpable stage. Dose-dependent response to cyclophosphamide was analyzed. Low dose was found to be most effective as compared to the high dose. Adoptive transfer of immunized splenocytes after cyclophosphamide therapy protects the animals from the danger of reappearance of tumor. Such combination therapy is proved to be effective in causing complete and permanent regression of tumor in majority of the treated animals.
Sarna
S
S
Department of Zoology, University of Gauhati, India.
Bhola
R K
RK
D000818:Animals; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D007116:Immunization, Passive; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000276:immunology
D003520:Cyclophosphamide