title: The haemodynamic effects of sublingual nitroglycerin spray in severe left ventricular failure.
abstract: The use of sublingual nitroglycerin spray has been studied in twenty patients referred to our Intensive Care Unit for further treatment of severe left ventricular failure. Within five minutes of spray administration significant falls in pulmonary artery occlusion pressure, mean arterial pressure, heart rate, right atrial pressure and systemic vascular resistance occurred. Similarly significant increases in cardiac index, stroke volume index and left ventricular stroke work index were found. These results show a considerable improvement in the haemodynamic parameters of invasively monitored patients and we believe that its administration undoubtedly "buys time" for the critically ill patient. However, we would caution against its routine use at present in view of the potential problem of hypotension, until further information is available.
authors.affiliation: Intensive Care Unit, University Hospital of South Manchester, Withington, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Edwards
authors.forename: P T
authors.initials: PT
authors.lastname: Grant
authors.forename: P
authors.initials: P
authors.lastname: Plunkett
authors.forename: P
authors.initials: P
authors.lastname: Nightingale
mesh_terms: D000286:Administration, Sublingual; D000336:Aerosols; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000336:Aerosols; D005996:Nitroglycerin