title: A multicentre trial in spontaneously breathing patients. A comparison of recovery following alfentanil or enflurane.
abstract: Recovery from anesthesia and the effect of premedication, induction agent and the individual anesthetist on the measure of recovery was assessed in 707 patients scheduled to undergo short surgical procedures. Patients were randomly allocated to receive either alfentanil or enflurane as a supplement to an induction agent, nitrous oxide/oxygen anesthetic technique with or without premedication. Patients who received alfentanil had a faster immediate recovery than those who received enflurane (p less than 0.001). Total anesthetic time was shorter in the alfentanil group (p = 0.02). For 36 of 37 anesthetists recovery was faster in the alfentanil group compared to the enflurane group. Choice of premedication and induction agent had a significant effect on recovery, thiopentone or lorazepam prolonged recovery time in each group. Although the alfentanil group had a higher incidence of apnoea, movement and vomiting (p less than 0.001), the enflurane group had a higher incidence of coughing (p less than 0.001) and shivering (p = 0.004). Overall the anesthetists assessed the alfentanil technique as excellent or good in more patients than the enflurane technique.
authors.affiliation: Medical Department, Janssen Pharmaceutical Limited, Wantage, Oxon.
authors.forename: S C
authors.initials: SC
authors.lastname: Hartley
authors.forename: D P
authors.initials: DP
authors.lastname: Cartwright
authors.forename: C J
authors.initials: CJ
authors.lastname: Wright
authors.forename: S H
authors.initials: SH
authors.lastname: Razvi
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil; D000762:Anesthesia Recovery Period; D000777:Anesthetics / Q000494:pharmacology*; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013511:Minor Surgical Procedures; D015337:Multicenter Studies as Topic; D011229:Preanesthetic Medication
chemical_list: D000759:Adjuvants, Anesthesia; D000777:Anesthetics; D015760:Alfentanil; D004737:Enflurane; D005283:Fentanyl