title: Homologues of catalytic domains of Cellulomonas glucanases found in fungal and Bacillus glycosidases.
abstract: We demonstrate homology between the catalytic domains of exoglucanase (1,4-beta-D-glucan cellobiohydrolase, EC 3.2.1.91) from Cellulomonas fimi and those of endoxylanases (1,4-beta-D-xylan xylanohydrolases, EC 3.2.1.8) from Bacillus sp. strain C-125 and the fungus Cryptococcus albidus; and between the catalytic domains of endoglucanase (1,4-(1,3:1,4)-beta-D-glucan 4-glucanohydrolase, EC 3.2.1.4) from Cellulomonas fimi and exoglucanase II from Trichoderma reesei. These five enzymes apparently evolved by reshuffling of two catalytic domains and several substrate-binding domains.
authors.affiliation: Protein Identification Resource, National Biomedical Research Foundation, Georgetown University Medical Center, Washington, DC 20007.
authors.forename: C A
authors.initials: CA
authors.lastname: West
authors.forename: A
authors.initials: A
authors.lastname: Elzanowski
authors.forename: L S
authors.initials: LS
authors.lastname: Yeh
authors.forename: W C
authors.initials: WC
authors.lastname: Barker
mesh_terms: D000192:Actinomycetales / Q000201:enzymology*; D000595:Amino Acid Sequence; D001407:Bacillus / Q000201:enzymology*; D002480:Cellulase / Q000032:analysis*; D003454:Cryptococcus / Q000201:enzymology*; D043364:Endo-1,4-beta Xylanases; D043326:Glucan 1,3-beta-Glucosidase; D005959:Glucosidases / Q000032:analysis*; D006026:Glycoside Hydrolases / Q000032:analysis*; D008969:Molecular Sequence Data; D014995:Xylosidases / Q000032:analysis*; D001617:beta-Glucosidase / Q000032:analysis*
chemical_list: D005959:Glucosidases; D006026:Glycoside Hydrolases; D014995:Xylosidases; D001617:beta-Glucosidase; D002480:Cellulase; D043326:Glucan 1,3-beta-Glucosidase; D043364:Endo-1,4-beta Xylanases