Pharmacokinetic disposition of pethidine under tolerance.
Under tolerance, evoked by multiple doses of pethidine (PD), the serum and brain tissue content of PD was related to diminished analgesic activity. Even though in tolerant rats no enhancement of PD biotransformation in the liver could be recognized (as followed by the measurement of hepatic esterase and N-demethylase activity), the amounts of both PD and nor-PD excreted in urine were increased under tolerance. The authors conclude that the faster disposition of PD may contribute to the development of tolerance.
Szczawińska
K
K
Department of Pharmacology, School of Medicine, Poznań.
Cenajek-Musiał
D
D
Nowakowska
E
E
Chodera
A
A
D000818:Animals; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance / Q000235:genetics*; D008614:Meperidine / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats
D008614:Meperidine