Parenteral nutrition including amino acids fails to increase creatinine clearance in catabolic patients.
A 70% increase in creatinine clearance (Ccr) has been reported previously in patients receiving parenteral nutrition (P.N.) with amino acids compared with P.N. without amino acids. We have investigated 10 male catabolic patients who got P.N. with and without amino acid solution. Twelve-hour Ccr was done on two consecutive days during infusion of P.N. On the second day 1000 ml of isotonic saline was replaced by 1000 ml of amino acid solution (Vamin 14g N/l). We found a statistically non-significant increase in Ccr (median: 1.6%, 95% confidence interval: -8.5% to 11.3%). In conclusion, no clinically important change in Ccr occurs in catabolic patients during P.N. with amino acids.
Jacobsen
B A
BA
Department of Medical Gastroenterology, Aalborg Hospital, Denmark.
Jensen
B N
BN
Mortensen
P B
PB
Borris
L C
LC
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000378:metabolism*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D010288:Parenteral Nutrition
D000596:Amino Acids; D005217:Fat Emulsions, Intravenous; D003404:Creatinine