Abnormal glomerular and tubular function during angiotensin converting enzyme inhibition in renovascular hypertension evaluated by the lithium clearance method.
Glomerular filtration rate (GFR) and tubular function were measured by means of the lithium clearance technique in 14 patients with renovascular hypertension (RVH) and eight patients with essential hypertension (EH) before and after oral administration of captopril 25 mg. In RVH captopril reduced 51-Cr-EDTA clearance (67.3 (median) to 47.5 ml min-1, P less than 0.01), proximal absolute reabsorption of fluid (53.9 to 41.5 ml min-1, P less than 0.01) and distal absolute reabsorption of sodium (2195 to 1402 mumol min-1, P less than 0.01), whereas proximal fractional reabsorption increased slightly (77.5 to 80.2%, P less than 0.02). In EH, however, these parameters were practically unaffected by captopril. In both RVH and EH plasma concentrations of angiotensin II and aldosterone were reduced after captopril, but atrial natriuretic peptide in plasma and urinary excretion rate of prostaglandin E2 were unchanged. Blood pressure decreased after captopril in both groups, but the maximum fall in systolic BP was more pronounced in RVH (22%) than EH (13%). It is concluded that angiotensin converting enzyme inhibition markedly reduced absolute reabsorption in both the proximal and distal tubules in RVH, in contrast to EH, predominantly due to fall in the GFR, and that the slight increase in proximal fractional reabsorption may be attributed to a reduction in the hydrostatic pressure in the peritubular vessels.
Pedersen
E B
EB
Department of Medicine C, Aarhus Kommunehospital, Denmark.
Sørensen
S S
SS
Amdisen
A
A
Danielsen
H
H
Eiskjaer
H
H
Hansen
H H
HH
Jensen
F T
FT
Jespersen
B
B
Madsen
B
B
Nielsen
H K
HK
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006874:Hydrostatic Pressure; D006973:Hypertension / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007684:Kidney Tubules / Q000187:drug effects / Q000503:physiopathology; D008094:Lithium / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged
D000804:Angiotensin II; D000450:Aldosterone; D008094:Lithium; D002216:Captopril