Effects of antiarrhythmic drugs in the isolated papillary muscle preparation of the guinea-pig.
Antiarrhythmic effects of a series of N-substituted derivatives of 2-amino-2-methylpropanol were studied using isolated papillary muscle preparation of guinea-pig heart in order to evaluate the chemical structure--biological activity relationship. All tested drugs were found to belong to the 1st group of antiarrhythmic agents characterized by the depression of normal electrophysiological properties of the heart muscle cell. The most active compounds were phenylethyl and p-bromophenylethyl derivatives, the effects of which were comparable with those of quinidine.
Bandolet
J
J
Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Rump
S
S
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007537:Isometric Contraction; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology; D011412:Propanolamines / Q000138:chemical synthesis / Q000494:pharmacology*; D011802:Quinidine / Q000494:pharmacology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; D011802:Quinidine; C006551:2-amino-2-methyl-1-propanol