Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.
Bonta
I L
IL
Department of Pharmacology, Medical Faculty, Erasmus University, Rotterdam, The Netherlands.
Elliott
G R
GR
Tak
C
C
Ben-Efraim
S
S
D000818:Animals; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism*; D008262:Macrophage Activation / Q000187:drug effects*; D009637:Masoprocol / Q000494:pharmacology; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D009637:Masoprocol; D008084:Lipoxygenase; D015232:Dinoprostone; D007213:Indomethacin