Progress in renal transplantation in Australia during 1975 to 1988.
The survival of 4,525 cadaver grafts in non-diabetic recipients during 1975 to 1988 showed marked improvement for both primary and subsequent transplants in all age groups, particularly in the first 3 months after transplantation. The effect of recipient serum cytotoxic antibody reactivity on graft survival was strikingly reduced for most patients, particularly those with a first graft. HLA incompatibility at the combined B and DR loci exerted more influence on graft survival than at either individual locus. The reduction in graft loss was associated with adoption of elective transfusion, establishment of a national donor kidney exchange scheme, increasing use of polyclonal and monoclonal antibodies, and introduction of cyclosporine A (CsA). Redoubled efforts are required to prevent and overcome the restricted access of highly sensitized patients to the increasingly successful outcome of renal transplantation.
Disney
A P
AP
Renal Unit, Queen Elizabeth Hospital, Woodville South, South Australia.
D000328:Adult; D000367:Age Factors; D000368:Aged; D003920:Diabetes Mellitus / Q000601:surgery; D006085:Graft Survival; D006680:HLA Antigens; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000639:trends; D008875:Middle Aged; D012086:Reoperation
D006680:HLA Antigens