title: Two DNA repair and recombination genes in Saccharomyces cerevisiae, RAD52 and RAD54, are induced during meiosis.
abstract: The DNA repair and recombination genes of Saccharomyces cerevisiae, RAD52 and RAD54, were transcriptionally induced approximately 10- to 15-fold in sporulating MATa/alpha cells. Congenic MATa/a cells, which did not sporulate, did not show similar increases. Assays of beta-galactosidase activity in strains harboring either a RAD52- or RAD54-lacZ gene fusion indicated that this induction occurred at a time concomitant with a commitment to meiotic recombination, as measured by prototroph formation from his1 heteroalleles.
authors.affiliation: Genetics Department, University of California, Berkeley 94720.
authors.forename: G M
authors.initials: GM
authors.lastname: Cole
authors.forename: D
authors.initials: D
authors.lastname: Schild
authors.forename: R K
authors.initials: RK
authors.lastname: Mortimer
mesh_terms: D004260:DNA Repair; D005786:Gene Expression Regulation; D005800:Genes, Fungal; D008540:Meiosis; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000502:physiology; D013172:Spores, Fungal / Q000502:physiology; D013997:Time Factors; D014158:Transcription, Genetic; D001616:beta-Galactosidase / Q000235:genetics
chemical_list: D001616:beta-Galactosidase