title: [A clinical and biological study of 11 cases of essential thrombocythemia].
abstract: 11 patients diagnosed as suffering from essential thrombocytosis at "Hospital Xeral de Lugo" between 1978 and 1986, are presented. 7 patients were female and 4 were male with a median age of 63 years. 6 patients had thrombotic manifestation, 6 had hemorrhagic symptoms, 2 had both manifestations and only one had no thrombo-hemorrhagic clinical symptoms. Spleen enlargement was found in 6 cases and liver enlargement in 5. The median count of platelets were 1.585.000 ml; there was no relationship between the amount and their function with the major or minor complications incidence. There was a good response to treatment with hydroxyurea and/or busulfan associated to platelets aggregation inhibitor in some cases. 4 patients died, all of them due to thrombotic complications.
authors.forename: J C
authors.initials: JC
authors.lastname: Corredoira
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Casariego
authors.forename: R
authors.initials: R
authors.lastname: Pérez
authors.forename: J F
authors.initials: JF
authors.lastname: García
authors.forename: M J
authors.initials: MJ
authors.lastname: López
authors.forename: M C
authors.initials: MC
authors.lastname: Castiñeira
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D013920:Thrombocythemia, Essential / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
vernacular_title: Estudio clínico y biológico de 11 casos de trombocitemia esencial.