In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine.
In vitro activities of 9-[( 2-hydroxyethoxy] methyl) guanine (acyclovir), (E)-5-(2-bromovinyl)-2'deoxyuridine, 9-beta-D-arabinofuranosyladenine (vidarabine), 5-iodo-2'-deoxyuridine (idoxuridine), and 5-trifluoromethyl-2'-deoxyuridine (trifluridine) were studied against 6 strains of feline herpesvirus-1. A significant difference was not detected among viral strains in their susceptibility to these compounds (P = 0.442). The relative potency of these compounds was trifluridine much greater than idoxuridine greater than vidarabine greater than bromovinyldeoxyuridine much greater than acyclovir. Concentrations of trifluridine and idoxuridine (0.67 and 6.8 microM, respectively) required to reduce plaque numbers by 50%, compared with that of controls, were significantly lower (P less than 0.001) than were those of other compounds.
Nasisse
M P
MP
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Guy
J S
JS
Davidson
M G
MG
Sussman
W
W
De Clercq
E
E
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D002415:Cats; D002460:Cell Line; D006564:Herpesviridae / Q000187:drug effects*; D007065:Idoxuridine / Q000494:pharmacology; D009500:Neutralization Tests; D014271:Trifluridine / Q000494:pharmacology; D014740:Vidarabine / Q000494:pharmacology
D000998:Antiviral Agents; C020235:brivudine; D014740:Vidarabine; D001973:Bromodeoxyuridine; D007065:Idoxuridine; D014271:Trifluridine; D000212:Acyclovir