title: An activating and cytotoxic effect of asbestos on polymorphonuclear leukocytes.
abstract: Chrysotile asbestos induces extensive enzyme release from polymorphonuclear leukocytes (PMNs). The release of the cytoplasmic enzyme lactate dehydrogenase implies membrane damage and cytotoxicity. In the presence of extracellular Ca2+ asbestos exerts an activating effect, evident from the release of granule-associated enzymes by exocytosis. Both the cytotoxic and activating effect of asbestos may contribute to asbestos-induced tissue damage.
authors.affiliation: Department of Medical Biochemistry, University of Leiden, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Elferink
authors.forename: M
authors.initials: M
authors.lastname: Deierkauf
authors.forename: J A
authors.initials: JA
authors.lastname: Kramps
authors.forename: H K
authors.initials: HK
authors.lastname: Koerten
mesh_terms: D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D002118:Calcium / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005089:Exocytosis / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D011817:Rabbits
chemical_list: D001194:Asbestos; D004492:Edetic Acid; D007770:L-Lactate Dehydrogenase; D008274:Magnesium; D002118:Calcium