Resistance of mice to genital infection with Neisseria gonorrhoeae.
Five strains of mice (C3H, CBA, BALB/c, TO and ICR) were inoculated intra-vaginally with Neisseria gonorrhoeae in an attempt to produce an animal model of gonorrhoea. Of a total of 68 mice inoculated, only three (4.4%) were culture-positive after 3 days. Histological examination of both the genital mucosa of inoculated animals, and the mucosa of genital tract organ cultures inoculated in vitro failed to show any evidence of gonococcal adherence or colonisation. Mice of these strains, therefore, appear resistant to gonococcal infection of the genital tract.
Johnson
A P
AP
Division of Sexually Transmitted Diseases, M.R.C. Clinical Research Centre, Harrow, Middlesex.
Tuffrey
M
M
Taylor-Robinson
D
D
D000818:Animals; D005260:Female; D005836:Genitalia, Female / Q000382:microbiology; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008813:Mice, Inbred ICR / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D009092:Mucous Membrane / Q000382:microbiology; D009344:Neisseria gonorrhoeae / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D009924:Organ Culture Techniques; D013045:Species Specificity; D013587:Syphilis / Q000276:immunology*