title: Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.
abstract: Certain lipids were found to inhibit the interaction between rho and R-ras proteins and their respective GTPase-activating proteins (GAP). Inhibitory lipids were similar for each protein but differed significantly from those previously found to inhibit the interaction between ras protein and GAP activity. These data raise the possibility that ras and related proteins are controlled biologically by interactions between lipids and GAP molecules.
authors.affiliation: Department of Molecular Biology, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: M H
authors.initials: MH
authors.lastname: Tsai
authors.forename: A
authors.initials: A
authors.lastname: Hall
authors.forename: D W
authors.initials: DW
authors.lastname: Stacey
mesh_terms: D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D007700:Kinetics; D008565:Membrane Proteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras); D020703:ras GTPase-Activating Proteins; D020743:rhoB GTP-Binding Protein
chemical_list: D020690:GTPase-Activating Proteins; D008565:Membrane Proteins; D010743:Phospholipids; D011506:Proteins; D011518:Proto-Oncogene Proteins; D020703:ras GTPase-Activating Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D016283:Proto-Oncogene Proteins p21(ras); D020743:rhoB GTP-Binding Protein