title: Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
abstract: In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.
authors.affiliation: Biozentrum, University of Basel, Switzerland.
authors.forename: J C
authors.initials: JC
authors.lastname: Shepherd
authors.forename: U
authors.initials: U
authors.lastname: Walldorf
authors.forename: P
authors.initials: P
authors.lastname: Hug
authors.forename: W J
authors.initials: WJ
authors.lastname: Gehring
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D015977:Eukaryotic Initiation Factor-1 / Q000235:genetics*; D008136:Longevity; D008297:Male; D009154:Mutation; D010957:Plasmids; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D015977:Eukaryotic Initiation Factor-1; D012333:RNA, Messenger