Congenital leukemia: persistent spontaneous regression in a patient with an acquired abnormal karyotype.
Congenital leukemia is a rare disease accounting for about 1% of all leukemias in childhood. While cases associated with Down's syndrome not infrequently show a spontaneous regression, such an event is very rare in non-Down cases and exceptional in those (among the latter) which present clonal cytogenetic alterations in the neoplastic cells. We present the case of a patient with congenital leukemia and an abnormal karyotype (limited to the neoplastic clone), in which an apparently spontaneous and prolonged remission occurred after a relapse.
Sansone
R
R
Center for Genetic Epidemiology and Oncogenetics, National Cancer Institute, Genova, Italy.
Haupt
R
R
Strigini
P
P
Garrè
M L
ML
Panarello
C
C
Cornaglia-Ferraris
P
P
D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D009365:Neoplasm Regression, Spontaneous; D012008:Recurrence