title: Anxiogenic effects of noreleagnine, a water soluble beta-carboline in rats.
abstract: We tested noreleagnine, a beta-carboline which unlike other beta-carbolines remains in aqueous solution at physiological pH, as well as chlordiazepoxide, a traditional benzodiazepine, and their interaction with the benzodiazepine receptor antagonist R0 15-1788 in a modified approach schedule with two levels of conflict. Noreleagnine displayed pro-conflict activity characteristic of beta-carbolines and chlordiazepoxide elicited an anti-conflict effect, both of which were blocked by pretreatment with R0 15-1788. We believe this to be the first clear demonstration that noreleagnine has an anxiogenic effect and that this effect is mediated by its action on benzodiazepine receptors.
authors.affiliation: Department of Pharmacology, Indiana University,School of Medicine, Indianapolis 46223.
authors.forename: A
authors.initials: A
authors.lastname: Shekhar
authors.forename: J N
authors.initials: JN
authors.lastname: Hingtgen
authors.forename: J A
authors.initials: JA
authors.lastname: DiMicco
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D002243:Carbolines / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003220:Conflict, Psychological / Q000187:drug effects; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
chemical_list: D002243:Carbolines; D005442:Flumazenil; C009804:tryptoline; D002707:Chlordiazepoxide; C024915:beta-carboline-3-carboxylic acid ethyl ester