title: Current concepts of the lethal midline granuloma syndrome.
abstract: "Lethal midline granuloma" is an unusual but devastating spectrum of lymphoproliferative disorders that is now thought to include four entities: idiopathic midline destructive disease, Wegener's granulomatosis, polymorphic reticulosis, and nasal lymphoma. These disorders must be considered in the differential diagnosis of any patient with chronic, nonspecific complaints localized to the upper airway. An aggressive diagnostic and therapeutic approach may significantly decrease morbidity and death resulting from these lesions.
authors.affiliation: Department of Surgery, East Tennessee State University.
authors.forename: J P
authors.initials: JP
authors.lastname: Pickens
authors.forename: L
authors.initials: L
authors.lastname: Modica
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006103:Granuloma, Lethal Midline / Q000175:diagnosis* / Q000188:drug therapy; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008223:Lymphoma / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D013577:Syndrome
chemical_list: D000477:Alkylating Agents