title: Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls.
abstract: We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 induces cytochrome P-452-linked enzyme activities in rats, but not in pigeons. This inductive effect was previously regarded as being specific for hypolipidemic drugs and phthalate ester plasticisers.
authors.affiliation: Department of Biochemistry & Physiology, University of Reading, Whiteknights, England.
authors.forename: J T
authors.initials: JT
authors.lastname: Borlakoglu
authors.forename: J D
authors.initials: JD
authors.lastname: Edwards-Webb
authors.forename: R R
authors.initials: RR
authors.lastname: Dils
authors.forename: J P
authors.initials: JP
authors.lastname: Wilkins
authors.forename: L W
authors.initials: LW
authors.lastname: Robertson
mesh_terms: D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D010856:Columbidae; D003580:Cytochromes / Q000096:biosynthesis*; D005260:Female; D006900:Hydroxylation; D007850:Lauric Acids / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
chemical_list: D001140:Aroclors; D003580:Cytochromes; D007850:Lauric Acids; D020111:Chlorodiphenyl (54% Chlorine); C030358:lauric acid; C046362:cytochrome P-452; D011078:Polychlorinated Biphenyls