title: Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study.
abstract: The effectiveness of Buserelin (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) (0.2 mg subcutaneously [SC] or 1.2 mg intranasally [IN] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. During 6 months of treatment, peripheral follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol concentrations were suppressed to a similar degree in both groups. Symptomatic improvement and laparoscopically assessed regression of endometriotic lesions also were comparable. After treatment, 8 of 18 infertile women treated with Buserelin and 5 of 8 treated with danazol conceived. General and hypoestrogenic side effects were similar in both groups, while androgenic and anabolic were more frequent with danazol. High density lipoprotein (HDL)-cholesterol increased in the Buserelin and decreased in the danazol group. The study indicates that at the dose tested, buserelin and danazol induce a similar degree of ovarian suppression resulting in a comparable clinical improvement and regression of endometriotic lesions.
authors.affiliation: Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60614.
authors.forename: W P
authors.initials: WP
authors.lastname: Dmowski
authors.forename: E
authors.initials: E
authors.lastname: Radwanska
authors.forename: Z
authors.initials: Z
authors.lastname: Binor
authors.forename: I
authors.initials: I
authors.lastname: Tummon
authors.forename: P
authors.initials: P
authors.lastname: Pepping
mesh_terms: D000328:Adult; D002064:Buserelin / Q000009:adverse effects / Q000627:therapeutic use*; D003613:Danazol / Q000009:adverse effects / Q000627:therapeutic use*; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D010386:Pelvic Neoplasms / Q000097:blood / Q000188:drug therapy*; D011245:Pregnadienes / Q000627:therapeutic use*; D011379:Prognosis; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D006728:Hormones; D011245:Pregnadienes; D003613:Danazol; D002064:Buserelin