[In vitro susceptibility of a strain of Rickettsia recently isolated from a case of Japanese spotted fever to chemotherapeutic agents].
The in vitro susceptibilities to five chemotherapeutic agents against a rickettsial strain which was isolated from a case of Japanese spotted fever were determined by cell culture system. Minocycline was the most effective (MIC, 0.15 micrograms/ml) followed by Tetracycline and Demethylchlor tetracycline (0.31 micrograms/ml 0.16 micrograms/ml). Chloramphenicol was less effective (5 micrograms/ml) and Aminobenzyl-penicillin was not effective with the MIC of 10 micrograms/ml or less. Thus, the earlier administration of Minocycline is recommended to clinically suspicious cases of Japanese spotted fever as well as Tsutsugamushi disease.
Suto
T
T
Hatakeyama
H
H
Ito
R
R
Nakamura
Y
Y
Mahara
F
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D012281:Rickettsia / Q000187:drug effects* / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents