[The effect of a lipid food component on enzymatic activity of rat liver endoplasmic reticulum upon the action of polychlorinated biphenyls].
The authors have studied the character of changes in the content of cytochrome P450 and b5, in the oxidation rate of amidopyrine, dimethyl-aniline and aniline, in the NADPH- and ascorbate-dependent lipid peroxidation systems, as well as in glucose-6-phosphatase and acetylesterase activities in the liver microsomes of the rats on semisynthetic diets, including 50% (according to calorific value) of butter or sunflower oil, or receiving fat-free diet (0.5% of sunflower oil) in different terms (4 and 70 days) after a single intragastric administration of a mixture of polychlorinated diphenyls, chlorinated biphenyl (500 mg/kg). It is shown that the degree and character of the microsomal enzymes studied, as well as the changes in the liver structure under the action of chlorinated biphenyl depend, to a certain extent, on the quality and quantity of fat in the diet.
Lashneva
N V
NV
Khan
A V
AV
Sorokovaia
G K
GK
Ishkova
V Iu
VIu
Gadzhiyeva
Z M
ZM
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D004798:Enzymes / Q000378:metabolism; D005506:Food Contamination; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D004798:Enzymes; D011078:Polychlorinated Biphenyls
Izuchenie vliianiia lipidnogo komponenta pishchi na aktivnost' fermentov éndoplazmaticheskogo retikulum pechenia krys pri vozdelstvii polikhlorirovannykh difenilov.