Evidence for the involvement of the central adrenergic system in the febrile response induced by interleukin-1 in rats.
We have studied the effect of noradrenaline- and serotonin-depleting agents on the febrile response induced by an intracerebroventricular (i.c.v.) injection of interleukin-1 (IL-1) in rats. Pretreatment with an injection into the lateral ventricle of the catecholamine-depleting agent, 6-hydroxydopamine (6-OHDA), abolished the febrile response induced by IL-1. Injection of 6-OHDA into the ventral noradrenergic ascending bundle (VNAB) did not affect the pyrogenic effect of IL-1. Pretreatment with the serotonin-depleting agent, 5,7-dihydroxytryptamine (5,7-DHT), did not inhibit the febrile response to IL-1. In addition, pretreatment with a beta-adrenergic blocker (propranolol) but not an alpha-adrenergic blocker (yohimbine) attenuated the fever induced by an i.c.v. injection of IL-1. These results suggest that the integrity of the central catecholaminergic system is important in mediating the IL-1-induced fever in rats. The central serotonergic system, as well as noradrenergic neurotransmission at the hypothalamus, do not appear to participate in this endogenous pyrogen-induced febrile response.
Ovadia
H
H
Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
Abramsky
O
O
Weidenfeld
J
J
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins; D012701:Serotonin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology
D006892:Hydroxydopamines; D007375:Interleukin-1; D009498:Neurotoxins; D011994:Recombinant Proteins; D013565:Sympatholytics; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D016627:Oxidopamine; D009638:Norepinephrine