Rolipram induces c-fos protein-like immunoreactivity in ependymal and glial-like cells in adult rat brain.
We tested the effects of the cyclic AMP-dependent phosphodiesterase inhibitor 4- (3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (rolipram) on c-fos protein-like immunoreactivity (FOS-IR) in adult rat brain. Rolipram (25-100 mg/kg, i.p.) did not detectability alter basal FOS-IR in neurons but induced FOS-IR in glial-like cells scattered in white matter regions and in ependymal cells lining the lateral and third ventricles. This induction was observed at 1 and 4 h after injection but was not detectable 10 min or 24 h after rolipram injection.
Dragunow
M
M
Department of Anatomy, School of Medicine, University of Auckland, New Zealand.
Faull
R L
RL
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D004805:Ependyma / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009457:Neuroglia / Q000378:metabolism*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D020889:Rolipram
D010726:Phosphodiesterase Inhibitors; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D011760:Pyrrolidinones; D020889:Rolipram