[Synthesis of new nitrosoureas].
Two chemical pathways were used for the synthesis of three new N'-(2-chloroethyl)-N-[2-(4-alkoxyphenylthio)ethyl]-N'-nitrosoureas and two new N'-(2-chloroethyl)-N)[2-(4-alkoxyphenyl-thio)ethyl]-N-nitrosoureas . The study of the cytotoxicity of the three N'-nitrosoureas, was carried out in two experimental models (P 388 and NSCLCN6).
Papadaki-Valiraki
A
A
Siatra-Papastaikoudi
T
T
Skaltsounis
A L
AL
Roussakis
C
C
D000818:Animals; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D009607:Nitrosourea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D009607:Nitrosourea Compounds
Synthèse de nouvelles nitrosourées.