title: Long-term anaesthesia with alfentanil and midazolam for lung transplantation in the dog.
abstract: An anaesthetic regime was developed for lung transplantation in the dog using a continuous infusion of alfentanil and midazolam. This combination of agents provided excellent analgesia and also produced loss of consciousness. Cardiovascular stability was well maintained over a 24-h period of anaesthesia following lung transplantation. Although no animals were allowed to recover from anaesthesia in the present series, the regime described is likely to be suitable for recovery anaesthesia, particularly since both of the agents used can be reversed with specific antagonists.
authors.affiliation: Comparative Biology Centre, Newcastle upon Tyne, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Flecknell
authors.forename: T L
authors.initials: TL
authors.lastname: Hooper
authors.forename: G
authors.initials: G
authors.lastname: Fetherstony
authors.forename: T J
authors.initials: TJ
authors.lastname: Locke
authors.forename: C G
authors.initials: CG
authors.lastname: McGregor
mesh_terms: D015760:Alfentanil; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs / Q000097:blood / Q000502:physiology / Q000601:surgery*; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D016040:Lung Transplantation; D008874:Midazolam / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D015760:Alfentanil; D008874:Midazolam; D005283:Fentanyl