A role for carbonic anhydrase in early eye morphogenesis.
The carbonic anhydrase inhibitor methazolamide was used to test the hypothesis that carbonic anhydrase activity plays a role in the early morphogenesis of the chick eye. Methazolamide was administered topically to eyes of 4-7-day-old chick embryos in shell-free culture. Either continuous application of drug solution with a miniosmotic pump or a single daily application of drug resulted in significant reduction in embryonic eye growth relative to sham-treated controls.
Linser
P J
PJ
Whitney Laboratory, St. Augustine, FL 32086.
Plunkett
J A
JA
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000502:physiology*; D002642:Chick Embryo; D046508:Culture Techniques; D007552:Isotonic Solutions / Q000494:pharmacology; D008704:Methazolamide / Q000494:pharmacology; D009799:Ocular Physiological Phenomena
D002257:Carbonic Anhydrase Inhibitors; D007552:Isotonic Solutions; C037692:Tyrode's solution; D002256:Carbonic Anhydrases; D008704:Methazolamide