[The effect of erythromycin treatment on natural killer (NK) cell activity in patients with chronic lower respiratory tract infections].
We measured NK activity before and after administration of erythromycin in 7 cases of chronic respiratory infection, and investigated the relationship between NK activity and improvement of the clinical syndrome. 1) We saw a significant rise in NK activity after treatment of erythromycin. Values before and after ranged from 40.0 +/- 21/2% to 62.0 +/- 32.7%. 2) There was no correlation between treatment period of erythromycin and the rate of rise in NK activity in the various cases such as rapidly rising cases or slowly rising cases, etc. 3) We saw a rise in NK activity before improvement of the clinical syndrome. Therefore it is suggested that treatment of erythromycin affects a rise in NK activity.
Mikasa
K
K
Sawaki
M
M
Konishi
M
M
Egawa
S
S
Yoneda
T
T
Yagyu
Y
Y
Fujimura
M
M
Hamada
K
K
Kunimatsu
M
M
Narita
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D004917:Erythromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D004917:Erythromycin