[Comparative study of the penetration of penicillin V, amoxicillin, cefaclor and josamycin in the tonsils].
Fourty patients undergoing tonsillectomy for recurrent tonsillitis were administered penicillin V, amoxicillin, cefaclor or josamycin. Antibiotic concentrations in serum and tonsillar tissues were determined by microbiological assay. Cefaclor demonstrated a superior diffusion than penicillin V and amoxicillin, but nevertheless inferior to that of josamycin.
Bizet
C
C
Laboratoire Central de Bactériologie, Hôpital Claude-Bernard, Paris, France.
Pangon
B
B
Moisy
N
N
Bizet
J
J
Bure
A
A
Gehanno
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000097:blood / Q000378:metabolism*; D002433:Cefaclor / Q000097:blood / Q000378:metabolism*; D002506:Cephalexin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000378:metabolism*; D010404:Penicillin V / Q000097:blood / Q000378:metabolism*; D011292:Premedication; D014068:Tonsillectomy; D014069:Tonsillitis / Q000188:drug therapy
D007933:Leucomycins; D002433:Cefaclor; D000658:Amoxicillin; D002506:Cephalexin; D010404:Penicillin V
Etude comparée de la pénétration de la pénicilline V, de l'amoxicilline, du céfaclor et de la josamycine dans les amygdales.