Exclusion of the dysplastic nevus syndrome (DNS) locus from the short arm of chromosome 1 by linkage studies in Dutch families.
Familial dysplastic nevus syndrome (DNS) is an autosomal dominant premalignant condition characterized by multiple large moles of variable size and color and a strongly increased risk for cutaneous malignant melanoma. In order to determine the chromosomal localization of the DNS gene, linkage studies were initiated in six large Dutch families. No support was obtained for linkage between the loci for DNS and the rhesus blood group on chromosome 1. Data from additional markers (DNF15S1, D1Z2, FUCA1, D1S17, D1S57, and PGM1) make it possible to exclude the DNS gene from the short arm of chromosome 1 in these Dutch families.
van Haeringen
A
A
Department of Human Genetics, State University, Leiden, The Netherlands.
Bergman
W
W
Nelen
M R
MR
van der Kooij-Meijs
E
E
Hendrikse
I
I
Wijnen
J T
JT
Khan
P M
PM
Klasen
E C
EC
Frants
R R
RR
D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D003627:Data Interpretation, Statistical; D004416:Dysplastic Nevus Syndrome / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D012204:Rh-Hr Blood-Group System / Q000235:genetics
D015342:DNA Probes; D005819:Genetic Markers; D012204:Rh-Hr Blood-Group System; D004247:DNA