[Participation of alveolar macrophages in the catabolism of fibrinogen and fibrin].
The penetration of FITC-fibrinogen in rabbit alveolar macrophages depends on Ca2+ and Mg2+. Therefore there is reason to believe the process is not restricted only by diffusion on concentration gradient, but pinocytosis takes place, which depends Ca2+. The absorption of FITC-label from fibrin by alveolar macrophages is more slow than from fibrinogen. Soluble high-molecular products of fibrin degradation can be trapped by pinocytosis. On the basis of such studies it was assumed that degradation of fibrin proceeds parietally.
Zubairov
D M
DM
Subkhankulova
F B
FB
Evranova
G B
GB
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D005456:Fluorescent Dyes; D008264:Macrophages / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011817:Rabbits; D013861:Thiocyanates; D013997:Time Factors
D005452:Fluoresceins; D005456:Fluorescent Dyes; D013861:Thiocyanates; D005337:Fibrin; D005340:Fibrinogen; D016650:Fluorescein-5-isothiocyanate; D008274:Magnesium; D002118:Calcium
Uchastie al'veoliarnykh makrofagov v katabolizme fibrinogena i fibrina.