title: Improved renal function during chronic lisinopril treatment in moderate to severe primary hypertension.
abstract: The effect of the converting enzyme inhibitor lisinopril on renal and cardiac hemodynamics was studied in patients with moderate to severe primary hypertension, in a multicenter, double-blind, randomized clinical trial comparing the antihypertensive effect of lisinopril (LIS) and nifedipine (NIF). After a 2 week placebo run-in period, 15 patients were randomized in a 2:1 ratio to receive either LIS (20-80 mg q.d., n = 10) or NIF (20-40 mg b.i.d., n = 5). LIS significantly reduced blood pressure (BP) without changing heart rate or cardiac output. LIS significantly increased renal blood flow; glomerular filtration rate (GFR) was not changed. It can be concluded that LIS is an effective antihypertensive agent with a favorable renal hemodynamic profile.
authors.affiliation: Department of Internal Medicine, University Hospital, Free University Brussels, Belgium.
authors.forename: A G
authors.initials: AG
authors.lastname: Dupont
authors.forename: P
authors.initials: P
authors.lastname: Van der Niepen
authors.forename: A
authors.initials: A
authors.lastname: Volckaert
authors.forename: M
authors.initials: M
authors.lastname: Ingels
authors.forename: A M
authors.initials: AM
authors.lastname: Bossuyt
authors.forename: M H
authors.initials: MH
authors.lastname: Jonckheer
authors.forename: R O
authors.initials: RO
authors.lastname: Six
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004656:Enalapril / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D017706:Lisinopril