[Effects of chemo-endocrine therapy on DMBA-induced rat mammary carcinoma].
The effect of chemo-endocrine therapy (5-FU plus TAM) on 7,12-DMBA-induced rat mammary carcinomas was studied in terms of its antitumor effects and changes in hormone receptors (ER and PgR). The study detected no difference in antitumor effects between combined administration of 5-FU and TAM, and either agent alone. The ER and PgR contents markedly decreased following chemo-endocrine therapy and endocrine therapy (TAM), but no significant decrease was achieved by chemotherapy (5-FU) alone. These results suggest that, in the combined administration of 5-FU and TAM, TAM was more effective than 5-FU. The expected advantage from chemo-endocrine therapy was not observed.
Yamamoto
H
H
Second Department of Surgery, Tokushima University School of Medicine, Japan.
Morimoto
T
T
Monden
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen; D015127:9,10-Dimethyl-1,2-benzanthracene; D005472:Fluorouracil