title: Immunoglobulin G subclass deficiency and susceptibility to pyogenic infections in patients with AIDS-related complex and AIDS.
abstract: Total immunoglobulin (Ig) and IgG subclass levels were measured in 72 patients with AIDS or AIDS-related complex (ARC). IgG2 subclass levels were found to be significantly decreased in the AIDS/ARC patients with pyogenic infections compared with both similar individuals without bacterial disease and the HIV-negative control group.
authors.affiliation: Department of Immunology, St Mary's Hospital and Medical School, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Parkin
authors.forename: M
authors.initials: M
authors.lastname: Helbert
authors.forename: C L
authors.initials: CL
authors.lastname: Hughes
authors.forename: A J
authors.initials: AJ
authors.lastname: Pinching
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D004198:Disease Susceptibility; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology*; D006801:Humans; D017099:IgG Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M