[Electroconvulsive therapy and its mechanism of action].
Electroconvulsive therapy (ECT) is known as an effective treatment for some depressive disorders. Nevertheless ECT continues to be a subject of controversy. The absence of a unifying theory for its mechanisms of action explains the mistrust about ECT. The aim of this article is to review the literature about ECT and to propose a synthesis concerning its mechanisms of action. At the present time, the most reliable hypothesis suggests selective activations of central serotonergic and dopaminergic systems on the one hand, and a direct stimulation of the neuroendocrine neurons on the other hand.
Couvreur
V
V
Unité de Psychiatrie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart Tilman.
Ansseau
M
M
Franck
G
G
D000818:Animals; D001921:Brain / Q000378:metabolism; D003866:Depressive Disorder / Q000628:therapy*; D004565:Electroconvulsive Therapy; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D009489:Neurosecretion
D009479:Neuropeptides
L'électroconvulsivothérapie et ses mécanismes d'actions.