Anxiogenic effects of noreleagnine, a water soluble beta-carboline in rats.
We tested noreleagnine, a beta-carboline which unlike other beta-carbolines remains in aqueous solution at physiological pH, as well as chlordiazepoxide, a traditional benzodiazepine, and their interaction with the benzodiazepine receptor antagonist R0 15-1788 in a modified approach schedule with two levels of conflict. Noreleagnine displayed pro-conflict activity characteristic of beta-carbolines and chlordiazepoxide elicited an anti-conflict effect, both of which were blocked by pretreatment with R0 15-1788. We believe this to be the first clear demonstration that noreleagnine has an anxiogenic effect and that this effect is mediated by its action on benzodiazepine receptors.
Shekhar
A
A
Department of Pharmacology, Indiana University,School of Medicine, Indianapolis 46223.
Hingtgen
J N
JN
DiMicco
J A
JA
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D002243:Carbolines / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003220:Conflict, Psychological / Q000187:drug effects; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D002243:Carbolines; D005442:Flumazenil; C009804:tryptoline; D002707:Chlordiazepoxide; C024915:beta-carboline-3-carboxylic acid ethyl ester