Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses.
The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lomefloxacin's elimination.
Kavi
J
J
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
Stone
J
J
Andrews
J M
JM
Ashby
J P
JP
Wise
R
R
D042462:4-Quinolones; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects; D024841:Fluoroquinolones; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D009343:Neisseria / Q000187:drug effects; D015363:Quinolones; D014018:Tissue Distribution
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin