Fructose mediated crosslinking of proteins.
10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.
Walton
D J
DJ
Department of Biochemistry, Queen's University, Kingston, Ontario, Canada.
McPherson
J D
JD
Shilton
B H
BH
D055598:Chemical Phenomena; D002621:Chemistry; D003459:Crystallins / Q000378:metabolism; D005632:Fructose / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D008239:Lysine / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism
D003459:Crystallins; D011506:Proteins; D012709:Serum Albumin; D005632:Fructose; D008239:Lysine