The spectrum of monoclonal immunoglobulin deposition disease associated with immunocytic dyscrasias.
Immunocytic dyscrasias may be manifested by MIDD often presenting with renal manifestations. The diagnosis is established when deposits are shown by immunopathologic methods to contain a single light-chain isotype in patients who have a monoclonal Ig in the serum or urine, altered kappa:lambda ratio in bone marrow, and/or abnormal biosynthesis of Igs in bone marrow cell cultures. The morphologic expressions of deposits are varied: fibrillar in AL, granular and punctate in LCDD, granular or crystalline in LHCDD, and crystalline in type I cryoglobulinemia.
Gallo
G
G
Department of Pathology, Kaplan Cancer Center, New York, NY.
Picken
M
M
Buxbaum
J
J
Frangione
B
B
D000686:Amyloidosis / Q000209:etiology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins