title: Lymphocyte migration patterns in autoimmune MRL-lpr/lpr mice: relationship to age, disease manifestations and lymphocyte homing receptor expression.
abstract: We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors. 51chromium-labelled lymph node cells from MRL/l and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/l compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/l and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/l mice appear as early as six weeks and are not related to changes in homing receptor expression.
authors.affiliation: Sydney University Department of Rheumatology, New South Wales, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Schrieber
authors.forename: N
authors.initials: N
authors.lastname: Manolios
authors.forename: M G
authors.initials: MG
authors.lastname: Cohen
authors.forename: S A
authors.initials: SA
authors.lastname: Paull
authors.forename: A K
authors.initials: AK
authors.lastname: Guiffre
authors.forename: K E
authors.initials: KE
authors.lastname: Hopper
mesh_terms: D000367:Age Factors; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002465:Cell Movement / Q000276:immunology; D006657:Histones / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D006657:Histones; D016201:Receptors, Lymphocyte Homing