The potentiating effect of growth hormone on follicle stimulation with human menopausal gonadotropin in a panhypopituitary patient.
A hypogonadotropic patient with primary pituitary insufficiency who has been previously treated for four cycles with hMG/hCG for ovulation induction is described. The hMG consumption was 76 to 96 ampules/cycle. Addition of GH (16 to 24 units/cycle) to hMG treatment was associated with a significant diminution in hMG consumption (35 to 36 ampules/cycle). The patient conceived on the second cycle of combined hMG/GH/hCG treatment. The possible role of GH as an adjunct to gonadotropin treatment is discussed, as well as the possible mechanisms of GH effects on the ovary.
Blumenfeld
Z
Z
Department of Obstetrics and Gynecology A, Rambam Medical Center, Haifa, Israel.
Lunenfeld
B
B
D000328:Adult; D000568:Amenorrhea / Q000150:complications; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D005306:Fertilization; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000503:physiopathology*; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000503:physiopathology*; D013268:Stimulation, Chemical
D006063:Chorionic Gonadotropin; D008596:Menotropins; D013006:Growth Hormone