A case of exercise-induced anaphylaxis: evidence of an association with the complement system.
We studied a 17-year-old girl with exercise-induced anaphylaxis (EIA). She experienced 10 episodes of EIA which demonstrated cutaneous, digestive and cardiorespiratory symptoms. This subject exhibited elevation in plasma histamine (13.3 ng/ml) and decrease in CH50 (17 U/ml) and C3 (70 mg/dl) after naturally induced EIA. On remission day CH50 (26 U/ml), C3 (83 mg/dl) and C4 (15 mg/dl) were of relatively low values. Her mother demonstrated the same tendency with a low level of C4 (14 mg/dl), and this suggested an underlying genetic disorder in the complement system. Exercise challenge could not elicit EIA symptomatically but showed fluctuation of CH50. The triggering mechanism of EIA was unclear; however there is a possibility that complement plays an important role in EIA.
Obata
T
T
Kishida
M
M
Okuma
M
M
Walsh
G M
GM
Iikura
Y
Y
D000293:Adolescent; D015444:Exercise; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*