title: Successful treatment of mitomycin C-associated hemolytic uremic syndrome by plasmapheresis.
abstract: Therapeutic attempts have generally failed to reverse the rapid progression of renal failure after mitomycin C (MMC)-induced hemolytic uremic syndrome (HUS). A patient who developed HUS after MMC and who showed pathologic changes in the kidney consistent with thrombotic microangiopathy is reported. Treatment with plasmapheresis was followed by a favorable outcome and significant recovery of renal function. Accordingly, this therapeutic modality should be considered for patients with MMC-induced HUS.
authors.affiliation: Istituto Scientifico di Medicina Interna, University of Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Garibotto
authors.forename: N
authors.initials: N
authors.lastname: Acquarone
authors.forename: S
authors.initials: S
authors.lastname: Saffioti
authors.forename: G
authors.initials: G
authors.lastname: Deferrari
authors.forename: B
authors.initials: B
authors.lastname: Villaggio
authors.forename: F
authors.initials: F
authors.lastname: Ferrario
mesh_terms: D000328:Adult; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000473:pathology; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects*; D010956:Plasmapheresis
chemical_list: D008937:Mitomycins; D016685:Mitomycin