Modification of cellular membrane functions by pendolmycin.
Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidylinositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12-O-tetradecanoylphorbol-13-acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolmycin inhibited binding of epidermal growth factor, activated arachidonic acid release and hexose transport, and inhibited binding of phorbol-12,13-dibutylate in C3H10T1/2 cells. Thus, pendolmycin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.
Umezawa
K
K
Institute of Microbial Chemistry, Tokyo.
Imoto
M
M
Yamashita
T
T
Sawa
T
T
Takeuchi
T
T
D000470:Alkaloids / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000378:metabolism; D008235:Lyngbya Toxins / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*
D000470:Alkaloids; D001095:Arachidonic Acids; D002273:Carcinogens; D008235:Lyngbya Toxins; D010716:Phosphatidylinositols; C059313:pendolmycin; C022176:teleocidins; D016718:Arachidonic Acid; D004815:Epidermal Growth Factor