The effect of chemical sympathectomy on natural killer cells in mice.
The nervous system affects immune regulation. We permanently ablated the sympathetic nervous system (SNS) of CBA mice with 6-OHDA at birth. Function of splenic natural killer (NK) cells in the sympathectomized mice was equivalent to controls at 2 weeks, but rose significantly above control levels at 4 weeks. NK cell function decreased below control values thereafter. NK cell numbers paralleled these changes in NK cell function. Our data suggest that the SNS may regulate the number and function of splenic NK cells during development.
Reder
A
A
Department of Neurology, University of Chicago, Illinois 60637.
Checinski
M
M
Chelmicka-Schorr
E
E
D000375:Aging / Q000276:immunology*; D000818:Animals; D006892:Hydroxydopamines; D007694:Killer Cells, Natural / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D016627:Oxidopamine; D013154:Spleen / Q000276:immunology* / Q000294:innervation / Q000502:physiology; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000276:immunology*
D006892:Hydroxydopamines; D016627:Oxidopamine