Metabolic effects of intravenous medium- and long-chain triacylglycerols in critically ill patients.
1. The metabolic effects of an intravenous lipid emulsion containing medium-chain triacylglycerols (MCT) and long-chain triacylglycerols (LCT) were studied in 16 critically ill, ventilated patients. The effects were compared in a cross-over study with those of a conventional emulsion containing only LCT. 2. The lipid was well tolerated but the metabolic effects of the MCT/LCT infusion differed from those of the LCT infusion. 3. The major differences were a 60% higher insulin concentration and a significantly greater increase in the plasma concentrations of non-esterified fatty acids during MCT/LCT infusion than during LCT infusion. The mean rise in plasma ketone concentration was also higher during MTC/LCT infusion, although this did not reach statistical significance.
Ball
M J
MJ
Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, U.K.
White
K
K
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002236:Carbohydrate Conformation; D003422:Critical Care; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood; D007659:Ketones / Q000097:blood; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007659:Ketones; D014280:Triglycerides; D005947:Glucose