title: Antibiotics from basidiomycetes. XXXI. Aleurodiscal: an antifungal sesterterpenoid from Aleurodiscus mirabilis (Berk. & Curt.) Höhn.
abstract: Aleurodiscal, an antifungal antibiotic has been isolated from mycelial cultures of Aleurodiscus mirabilis (Berk. & Curt.) Höhn. It causes abnormal apical branchings of Mucor miehei hyphae at very low concentrations. The structure and absolute configuration of the antibiotic has been determined by a single crystal X-ray analysis and hydrolysis to D-(+)-xylose. Aleurodiscal is a hydroxysesterterpene aldehyde beta-D-xyloside with a novel carbon skeleton.
authors.affiliation: Lehrbereich Biotechnologie der Universität, Kaiserslautern, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Lauer
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: W S
authors.initials: WS
authors.lastname: Sheldrick
authors.forename: A
authors.initials: A
authors.lastname: Scherer
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005779:Immunodiffusion; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects*; D014961:X-Ray Diffraction
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C060106:aleurodiscal