title: [Vascular responses in cerebrovascular "Moyamoya" disease--evaluated by positron emission tomography].
abstract: We investigated cerebral blood flow and metabolism, and cerebral vascular response in 9 patients with cerebrovascular Moyamoya disease or unilateral Moyamoya phenomenon using positron emission tomography (PET). The subjects consisted of 5 men and 4 women, and were from 9 to 60 years old. Five patients had bilateral occlusion in the carotid fork with Moyamoya vessels (fulfilled the criteria of cerebrovascular Moyamoya disease), and four patients had unilateral Moyamoya phenomenon. The PET scanner used was the HEADTOME III, of which spatial resolution in clinical use was 10 mm full width at half-maximum (FWHM) in the image plane. Cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), cerebral oxygen extraction fraction (OEF), and cerebral blood volume (CBV) were measured in resting state by the 15O-labelled gases steady state method in every patient and 22 normal controls (17 men and 5 women, and from 26 to 64 years old). Consecutively cerebral vascular responses were measured by H215O autoradiographic method in resting state, hypercapnia, hypocapnia, and hypertension. Forced hypercapnia, hypocapnia, and hypertension were achieved by 7% CO2 inhalation, hyperventilation, and venous infusion of angiotensin II, respectively. CMRO2 of the whole brain was significantly lower in patients than in normal controls (p less than 0.05), and CBV of the lentiform nucleus significantly increased in patients (p less than 0.01). This reflected Moyamoya vessels in the basal ganglionic regions. In 3 of 5 patients with bilateral Moyamoya vessels, CBF and CMRO2 in the symptomatic cerebral hemisphere were lower than that in the nonsymptomatic hemisphere.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tomura
authors.forename: I
authors.initials: I
authors.lastname: Kanno
authors.forename: F
authors.initials: F
authors.lastname: Shishido
authors.forename: S
authors.initials: S
authors.lastname: Higano
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Inugami
authors.forename: K
authors.initials: K
authors.lastname: Tabata
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: I
authors.initials: I
authors.lastname: Sayama
authors.forename: N
authors.initials: N
authors.lastname: Yasui
mesh_terms: D000293:Adolescent; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure; D001810:Blood Volume; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D010101:Oxygen Consumption; D014055:Tomography, Emission-Computed; D014661:Vasoconstriction; D014664:Vasodilation
chemical_list: D002245:Carbon Dioxide