title: Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis.
abstract: One hundred five patients were enrolled in a 12-week, randomized, prospective, double-blind, placebo-controlled trial of recombinant human gamma-interferon (rHu gamma-IFN) for the treatment of rheumatoid arthritis. Fifty-four patients received rHu gamma-IFN and 51 received placebo. Forty-two patients in each group completed the 12-week trial. Some clinical improvement occurred in both groups of patients. Although the improvement with rHu gamma-IFN was greater than that with placebo, the differences were generally not statistically significant.
authors.affiliation: University of Utah, Salt Lake City.
authors.forename: G W
authors.initials: GW
authors.lastname: Cannon
authors.forename: S H
authors.initials: SH
authors.lastname: Pincus
authors.forename: R D
authors.initials: RD
authors.lastname: Emkey
authors.forename: A
authors.initials: A
authors.lastname: Denes
authors.forename: S A
authors.initials: SA
authors.lastname: Cohen
authors.forename: F
authors.initials: F
authors.lastname: Wolfe
authors.forename: P A
authors.initials: PA
authors.lastname: Saway
authors.forename: A M
authors.initials: AM
authors.lastname: Jaffer
authors.forename: A L
authors.initials: AL
authors.lastname: Weaver
authors.forename: L
authors.initials: L
authors.lastname: Cogen
mesh_terms: D000328:Adult; D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000009:adverse effects / Q000627:therapeutic use*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D010919:Placebos / Q000627:therapeutic use*; D011994:Recombinant Proteins; D013997:Time Factors
chemical_list: D000954:Antigens, Surface; D008565:Membrane Proteins; D010919:Placebos; D011994:Recombinant Proteins; D007371:Interferon-gamma