[Experimental vaccinal prophylaxis of Pseudomonas aeruginosa burn sepsis].
After the injection of P. aeruginosa live culture under the burned skin of mice sepsis develops within the first 24 hours, finally leading to the death of the animals. The microorganisms can be isolated from the blood, liver, kidneys and mesenterial lymph nodes till day 3 and from the spleen till day 5. After the intraperitoneal injection of P. aeruginosa live culture into mice, sepsis also develops within 24 hours, and the culture can be isolated from the blood and parenchymatous organs till day 3. The LD50 of the culture is equal to 5.1 X 10(6) microbial cells when introduced intraperitoneally and to 30 microbial cells in experimental burn sepsis. Experimental burn sepsis clearly demonstrates the effectiveness of Pseudomonas acellular protein vaccine: its index of effectiveness exceeds 3,000.
Bandman
O A
OA
Stanislavskiĭ
E S
ES
Kholodkova
E V
EV
Ivanova
T V
TV
Salov
V F
VF
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002056:Burns / Q000150:complications* / Q000382:microbiology; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008808:Mice, Inbred CBA; D011552:Pseudomonas Infections / Q000382:microbiology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D001428:Bacterial Vaccines
Vaktsinoprofilaktika sinegnoĭnogo ozhogovogo sepsisa v éksperimente.