title: The spectrum of monoclonal immunoglobulin deposition disease associated with immunocytic dyscrasias.
abstract: Immunocytic dyscrasias may be manifested by MIDD often presenting with renal manifestations. The diagnosis is established when deposits are shown by immunopathologic methods to contain a single light-chain isotype in patients who have a monoclonal Ig in the serum or urine, altered kappa:lambda ratio in bone marrow, and/or abnormal biosynthesis of Igs in bone marrow cell cultures. The morphologic expressions of deposits are varied: fibrillar in AL, granular and punctate in LCDD, granular or crystalline in LHCDD, and crystalline in type I cryoglobulinemia.
authors.affiliation: Department of Pathology, Kaplan Cancer Center, New York, NY.
authors.forename: G
authors.initials: G
authors.lastname: Gallo
authors.forename: M
authors.initials: M
authors.lastname: Picken
authors.forename: J
authors.initials: J
authors.lastname: Buxbaum
authors.forename: B
authors.initials: B
authors.lastname: Frangione
mesh_terms: D000686:Amyloidosis / Q000209:etiology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins