Interleukin 6 and plasma cell neoplasias.
Interleukin 6, an essential factor for B cells to differentiate to immunoglobulin-producing cells has been demonstrated to be involved in abnormal polyclonal plasmacytosis in cardiac myxoma. Castleman's disease, rheumatoid arthritis and AIDS. Furthermore, IL-6 was found to be a potent growth factor for both plasmacytoma and myeloma. The involvement of IL-6 in plasma cell abnormalities was further demonstrated by the generation of a lethal plasma cell growth in IL-6 transgenic mice. Continuous IL-6 gene expression could be considered to play an essential role in both polyclonal plasmacytosis and the generation of plasma cell neoplasias.
Hirano
T
T
Division of Immunology, Osaka University, Japan.
Kishimoto
T
T
D000818:Animals; D002452:Cell Count; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010950:Plasma Cells / Q000166:cytology*; D010954:Plasmacytoma / Q000209:etiology*; D011971:Receptors, Immunologic / Q000378:metabolism; D019947:Receptors, Interleukin-6
D015850:Interleukin-6; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6