A mutant cell in which association of class I heavy and light chains is induced by viral peptides.
Association of the Db heavy chain with beta 2-microglobulin and expression of Db and Kb at the surface of the cell are induced by specific peptides in the mutant RMA-S. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin, and transport of the antigen-MHC complex to the cell surface.
Townsend
A
A
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, England.
Ohlën
C
C
Foster
L
L
Bastin
J
J
Ljunggren
H G
HG
Kärre
K
K
D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D000939:Epitopes / Q000378:metabolism; D006183:H-2 Antigens / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000276:immunology / Q000378:metabolism
D000939:Epitopes; D006183:H-2 Antigens; D014764:Viral Proteins; D001613:beta 2-Microglobulin