title: Positron emission tomography in manganese intoxication.
abstract: We employed 6-fluorodopa to study the integrity of the nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features of mild parkinsonism caused by exposure to manganese. The 6-fluorodopa scans were normal. This finding suggests that in early manganism sufficient to cause parkinsonian deficits, damage may occur in pathways postsynaptic to the nigrostriatal system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose scans showed decreased cortical glucose metabolism, the significance of which is discussed.
authors.affiliation: Belzberg Laboratory of Clinical Neuroscience, UBC Health Sciences Centre Hospital, Vancouver, Canada.
authors.forename: E C
authors.initials: EC
authors.lastname: Wolters
authors.forename: C C
authors.initials: CC
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Clark
authors.forename: R F
authors.initials: RF
authors.lastname: Peppard
authors.forename: J
authors.initials: J
authors.lastname: Okada
authors.forename: N S
authors.initials: NS
authors.lastname: Chu
authors.forename: M J
authors.initials: MJ
authors.lastname: Adam
authors.forename: T J
authors.initials: TJ
authors.lastname: Ruth
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: D B
authors.initials: DB
authors.lastname: Calne
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002908:Chronic Disease; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D020149:Manganese Poisoning; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine