[Effects of exposure time using preliminary concentrations on the mutagenic effect of the basic action of one-center and dual-center mutagens].
The effect of exposition with pretreatment for thiophosphamide and dipin of human lymphocytes at Go phase was investigated. There were used 5 low concentrations of mutagens: 2, 0, 2; 2.10(-2); 2.10(-3), 2.10(-4) mcg/ml with different exposure: 1/4 hr, 1/2 hr, 1 hr and 4 hr and high concentration of 20 mcg/ml by which cell have been treated. There was discovered the dependence of the "protective" concentration on the exposition: the increase of exposition of pretreatment induced the decrease of "protective" concentration and vice versa.
Tulina
A N
AN
Chebotarev
A N
AN
D000477:Alkylating Agents / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000633:toxicity*; D001388:Aziridines / Q000633:toxicity*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003470:Culture Media; D006801:Humans; D008214:Lymphocytes; D009152:Mutagenicity Tests; D009153:Mutagens; D013852:Thiotepa / Q000633:toxicity*; D013997:Time Factors
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D001388:Aziridines; D003470:Culture Media; D009153:Mutagens; D013852:Thiotepa; C007526:dipin
Vliianie vremeni ékspozitsii predvaritel'noĭ kontsentratsieĭ na mutagennyĭ éffekt osnovnogo vozdeĭstviia u odno- i dvukhtsentrovykh mutagenov.