Mono(ADP-ribosyl)ation of Gi by eukaryotic cysteine-specific mono(ADP-ribosyl) transferase attenuates inhibition of adenylate cyclase by epinephrine.
Eukaryotic cysteine-specific mono(ADP-ribosyl)transferase, named ADP-ribosyltransferase C (Tanuma, S., Kawashima, K. and Endo, H. (1988) J. Biol. Chem. 263, 5485-5489), attenuates inhibition of adenylate cyclase in human platelet membranes by epinephrine. This attenuation appeared to result from mono(ADP-ribosyl)ation by ADP-ribosyltransferase C of the inhibitory guanine nucleotide-binding protein (Gi) of adenylate cyclase. These results indicate a role of ADP-ribosyltransferase C in regulation of hormonal control of the adenylate cyclase system.
Tanuma
S
S
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Endo
H
H
D036002:ADP Ribose Transferases / Q000097:blood*; D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D001905:Botulinum Toxins; D002462:Cell Membrane / Q000378:metabolism; D005576:Colforsin / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D019204:GTP-Binding Proteins / Q000097:blood*; D006801:Humans; D007700:Kinetics; D009243:NAD / Q000097:blood; D009249:NADP / Q000097:blood
D000067956:Adenylyl Cyclase Inhibitors; D009243:NAD; D005576:Colforsin; D009249:NADP; D036002:ADP Ribose Transferases; C063007:exoenzyme C3, Clostridium botulinum; D001905:Botulinum Toxins; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases; D004837:Epinephrine