[Pharmacokinetics of preparations of lipoic acid and their effect on ATP synthesis, processes of microsomal and cytosol oxidation in hepatocytes in liver damage in man].
The features of the pharmacokinetics of preparations of alpha-lipoic acid (lipoic acid, thioctacide) as compared with their pharmacodynamic effects were studied in 125 patients with chronic diffuse diseases of the liver of viral and alcohol etiology. After a single administration of the preparations, the authors found an elevation of the maximal blood concentrations and an increase of alpha-lipoic acid elimination half-life in patients with liver cirrhosis as compared with chronic hepatitis patients. During the replacement therapy and elimination of alpha-lipoic acid deficiency by using the preparations containing lipoic acid, there is commonly an increase ATP content, an elevation of functioning mass of hepatocytes and activation of liver detoxifying function according to the data of the tests of galactose cytosol oxidation, microsomal oxidation of antipyrine and conjugation of bilirubin.
Loginov
A S
AS
Nilova
T V
TV
Bendikov
E A
EA
Petrakov
A V
AV
D000255:Adenosine Triphosphate / Q000096:biosynthesis* / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D008063:Thioctic Acid / Q000493:pharmacokinetics* / Q000494:pharmacology
D008063:Thioctic Acid; D000255:Adenosine Triphosphate
Farmakokinetika preparatov lipoevoĭ kisloty i ikh vliianie na sintez ATF, protsessy mikrosomal'nogo i tsitozol'nogo okisleniia v gepatotsitakh pri porazhenii pecheni u cheloveka.