title: The interaction between catecholaminergic and peptidergic perivascular nerve fibres in the innervation of the rat mesenteric vascular bed.
abstract: The interaction between catecholaminergic and peptidergic fibres innervating the rat mesenteric vascular bed was investigated by independently inhibiting the development of one or other system. Through examination of electron microscopic and immunohistochemical preparations it was determined that an increased density of catecholaminergic innervation occurred in the absence of peptidergic innervation, but that a decreased density of peptidergic innervation occurred in the absence of catecholaminergic innervation. These results indicate an interaction between the two systems which may take place directly, indirectly through a third factor, or in the case of a decrease in density directly through the loss of mixed fibre bundles normally formed predominantly by one fibre type.
authors.affiliation: Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Woolgar
authors.forename: T M
authors.initials: TM
authors.lastname: Scott
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008638:Mesenteric Arteries / Q000294:innervation*; D008642:Mesenteric Veins / Q000294:innervation*; D009412:Nerve Fibers / Q000187:drug effects; D016627:Oxidopamine; D010455:Peptides / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002395:Catecholamines; D006892:Hydroxydopamines; D010455:Peptides; D016627:Oxidopamine; D002211:Capsaicin