Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.
LY134046, a potent, selective inhibitor of rat brain phenylethanolamine N-methyltransferase, was shown to increase activity in 18- and 19-day-old rats. The effects on day 25 were different, with LY134046 causing a decrease in activity. The effects of yohimbine, a selective antagonist of the alpha-2 adrenergic receptor, were markedly different from LY134046, causing a decrease in activity on day 19. These data suggest that epinephrine synthesis may play an inhibitory role in the regulation of activity in young rats.
Mefford
I N
IN
Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
Lawrenz
A L
AL
Hsiao
J K
JK
Crawley
J N
JN
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010625:Phenylethanolamine N-Methyltransferase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology
D001552:Benzazepines; D015016:Yohimbine; C028625:LY 134046; D010625:Phenylethanolamine N-Methyltransferase