[Experimental chemotherapy using transplantable human oral cancer in nude mice by SRC assay].
I studied fundamentally 6-days subrenal capsule assay, using human oral cancer transplanted in nude mice. The relative variation of tumor size (delta TS/TSO) was calculated as follows; delta TS/TSO = (TS6-TSO)/TSO X 100(%), where TS 6 was the tumor size on day 6 and TSO that on day O, and more than a 10% decrease of delta TS/TSO in the treated group was considered as positive for chemosensitivity. The chemosensitive rates were 38.0 +/- 8.1% (mean +/- standard deviation) for control, -8.0 +/- 8.5% for 5-FU, 1.8 +/- 16.7 for PEP, 5.0 +/- 9.1% for CDDP, -26 +/- 9.6% for 5-FU + PEP and -17.0 +/- 6.7% for 5-FU + CDDP. A single chemotherapy was negative, but combination chemotherapy was positive and few side effects (body weight loss) was showed. The 6-days SRC assay (combined anticancer drugs) appeared to be useful for selecting sensitive drugs for oral cancer patient.
Mochizuki
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D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D008819:Mice, Nude; D009062:Mouth Neoplasms / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy