[Preventive effects of intra-arterial infusion chemotherapy of liver metastasis in non-resectable pancreatic cancer].
This is a study which evaluates intra-arterial chemotherapy for non-resectable carcinoma of the pancreas without liver metastasis (locally advanced). Twenty-one patients received ia-chemotherapy (MA-CP: Methotrexate + Angiotensin II----Citrovorum factor + Prostaglandin E1). They showed a 39% 1-year survival rate and 92% of 1-year cumulative rate of survival without liver metastasis. These incidences were significantly higher than those of (13%, 50%) 52 patients who underwent systemic chemotherapy (control). As the reason for such significant differences, we suspected that a high dose of chemotherapeutic view after MTX had been infused into the pancreatic-supplying arteries. This speculation was confirmed by the serial determination of the MTX concentration in the portal blood.
Yasuda
T
T
Dept. of Surgery, Center for Adult Diseases, Osaka.
Ishikawa
O
O
Ohigashi
H
H
Shibata
T
T
Sasaki
Y
Y
Hiratsuka
M
M
Kabuto
T
T
Furukawa
H
H
Imaoka
S
S
Iwanaga
T
T
D000527:Alprostadil / Q000008:administration & dosage; D000804:Angiotensin II / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000097:blood; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000097:blood; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011169:Portal Vein
D008937:Mitomycins; D000804:Angiotensin II; D016685:Mitomycin; D000527:Alprostadil; D002955:Leucovorin; D008727:Methotrexate