In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1.
Using in situ hybridization, we have localized the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. The precise genomic site is of interest since the region 12q13-15 has been found to be consistently rearranged in neoplasia-associated chromosome abnormalities in lipomas, myxoid liposarcomas, uterine leiomyomas, and pleomorphic adenomas of the salivary gland.
Arheden
K
K
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Rønne
M
M
Mandahl
N
N
Heim
S
S
Kinzler
K W
KW
Vogelstein
B
B
Mitelman
F
F
D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D004273:DNA, Neoplasm / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008667:Metalloproteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D008667:Metalloproteins