title: [Role of c-myc protein in the early embryonic development of Xenopus].
abstract: Microinjections of antibodies directed against the protein encoded by the c-myc protooncogene strongly inhibit or arrest the early cell cleavage stage of Xenopus laevis embryos. Injections in one blastomere of a two cell stage embryo inhibit the segmentation of this blastomere. The cleavage of the uninjected blastomere behaves normally. Injections of control rabbit immunoglobulins do not alter the embryonic development.
authors.affiliation: Institut Jacques-Monod, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Méchali
authors.forename: G
authors.initials: G
authors.lastname: Evan
authors.forename: M
authors.initials: M
authors.lastname: Gusse
mesh_terms: D000818:Animals; D000906:Antibodies; D000941:Antigens / Q000276:immunology; D001757:Blastomeres / Q000166:cytology*; D002455:Cell Division; D007158:Immunologic Techniques; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc; D014982:Xenopus laevis / Q000196:embryology*
chemical_list: D000906:Antibodies; D000941:Antigens; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc
vernacular_title: Rôle de la protéin c-myc dans le développement embryonnaire précoce chez le Xénope.