title: Pituitary hyposecretion and hypersecretion produced by a Rathke's cleft cyst presenting as a noncystic hypothalamic mass.
abstract: A 53-year-old man presented with polydipsia, polyuria, lightheadedness on standing, and syncope. Visual field deficits suggesting left optic tract compression and pituitary dysfunction consisting of diabetes insipidus, hyperprolactinemia, and anterior pituitary insufficiency were diagnosed. On the computed tomography scan, an isodense, ring-enhancing, parasellar mass was localized primarily in the suprasellar region and also extended into the sella. It was believed that the pituitary hormone hypersecretion and hyposecretion were due to hypothalamic dysfunction from the mass which was initially believed to be a craniopharyngioma. At surgery a Rathke's cleft cyst was resected. The unusual presentation of this Rathke's cleft cyst presenting as a hypothalamic lesion is discussed.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine and Hospital, Baltimore.
authors.forename: M
authors.initials: M
authors.lastname: Wenzel
authors.forename: M
authors.initials: M
authors.lastname: Salcman
authors.forename: D A
authors.initials: DA
authors.lastname: Kristt
authors.forename: F E
authors.initials: FE
authors.lastname: Gellad
authors.forename: L P
authors.initials: LP
authors.lastname: Kapcala
mesh_terms: D003397:Craniopharyngioma / Q000150:complications* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007027:Hypothalamic Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D014057:Tomography, X-Ray Computed
chemical_list: D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin