title: High urinary excretion of glycosaminoglycans: a possible marker of glomerular involvement in diabetes.
abstract: Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans. A lysine provocative test in these subjects disclosed abnormal urinary excretion of albumin, unlike findings obtained in insulin-dependent diabetic patients with normal urinary excretion rates of glycosaminoglycans. These data support the hypothesis that high urinary excretion of glycosaminoglycans is a marker of glomerular involvement in diabetes mellitus.
authors.affiliation: Institute of Internal Medicine, University of Padova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gambaro
authors.forename: E
authors.initials: E
authors.lastname: Cicerello
authors.forename: S
authors.initials: S
authors.lastname: Mastrosimone
authors.forename: T
authors.initials: T
authors.lastname: Lavagnini
authors.forename: B
authors.initials: B
authors.lastname: Baggio
mesh_terms: D000328:Adult; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000652:urine; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008239:Lysine; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D006025:Glycosaminoglycans; D008239:Lysine