Interferon-gamma as an adjuvant in immunocompromised mice.
We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states.
Heath
A W
AW
Department of Immunology, U.C.S.M., London, U.K.
Devey
M E
ME
Brown
I N
IN
Richards
C E
CE
Playfair
J H
JH
D000276:Adjuvants, Immunologic; D000818:Animals; D000915:Antibody Affinity; D005260:Female; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology*; D008212:Lymphocyte Depletion; D008297:Male; D051379:Mice; D011994:Recombinant Proteins; D013601:T-Lymphocytes
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D007371:Interferon-gamma