Antibacterial prophylaxis with lactoferrin in neutropenic patients.
The prevention of enterogenic infection by human lactoferrin was tested in five neutropenic patients receiving chemotherapy for acute myelogenous leukemia. Lactoferrin did not significantly delay the onset of infection but reduced its duration and severity as judged from the course of fever. Compared with nine matched controls, lactoferrin-treated patients had a lower incidence of bacteremia on the whole and of gram-negative bacteremia in particular.
Trümpler
U
U
Department of Internal Medicine, Medizinische Klinik, University Hospital, Bern, Switzerland.
Straub
P W
PW
Rosenmund
A
A
D000293:Adolescent; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D005260:Female; D005334:Fever; D006801:Humans; D007781:Lactoferrin / Q000627:therapeutic use*; D007782:Lactoglobulins / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications; D018805:Sepsis / Q000517:prevention & control*
D007782:Lactoglobulins; D007781:Lactoferrin