Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions.
Separate groups of rats with unilateral 6-OHDA lesions of the nigrostriatal pathway received intrastriatal foetal (E14) substantia nigra suspension grafts, intrastriatal postnatal (P22-25) adrenal medulla suspension grafts using either collagenase- or trypsin-based dissociation procedures, intraventricular adrenal medulla grafts, or remained with lesions alone. Rats with nigral or adrenal suspension grafts, but not rats with adrenal solid grafts, showed reduced apomorphine-induced rotation in comparison with lesion rats. The nigral graft group alone showed substantial reduction of amphetamine-induced rotation, and this was the only group manifesting good long-term graft survival. These results indicate that nigral and adrenal grafts do not have comparable mechanisms of functional action, and suggest that adrenal grafts can ameliorate apomorphine-induced rotation by a non-specific mechanism.
Brown
V J
VJ
Department of Experimental Psychology, University of Cambridge, U.K.
Dunnett
S B
SB
D000313:Adrenal Medulla / Q000378:metabolism* / Q000637:transplantation*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002469:Cell Separation; D003342:Corpus Striatum; D004622:Embryo, Mammalian; D005260:Female; D006892:Hydroxydopamines; D008694:Methamphetamine / Q000494:pharmacology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000378:metabolism* / Q000502:physiology / Q000637:transplantation*
D006892:Hydroxydopamines; D008694:Methamphetamine; D016627:Oxidopamine; D001058:Apomorphine