title: A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.
abstract: Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. The cloned cDNA sequence included a new insert of 93 nucleotides, which added a fourth repeat to the three-repeat type of tau already reported. Perhaps, this four-repeat type of tau is predominant in normal aged brain. In contrast, the sequence analysis of paired helical filaments showed that the integrated tau is of three-repeat type. This indicates that a distinct form of tau is selectively incorporated into paired helical filaments.
authors.affiliation: 2nd Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Honda
authors.forename: J
authors.initials: J
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Ihara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002540:Cerebral Cortex / Q000378:metabolism; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012016:Reference Values; D016875:tau Proteins
chemical_list: D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D016875:tau Proteins; D004247:DNA