Total lymphoid irradiation reduces IgG autoantibody production and enhances specific antibody responses in NZB/NZW F1 mice.
Thymus-independent primary antibody responses were studied in young and old (9 months) untreated and TLI-treated NZB/NZW and BALB/c mice. Untreated old NZB/NZW mice had a low primary response to Brucella abortus (BA) as compared to that of young NZB/NZW and BALB/c mice. However, TLI treatment resulted in a 130-fold increase in the IgG anti-BA primary antibody response at day 21 postimmunization, achieving similar levels to those of young NZB/NZW or nonautoimmune BALB/c mice. Anti-TNP responses to trinitrophenylated BA or Ficoll were masked by high background levels of anti-TNP antibodies. Despite the increase in the anti-BA response, spontaneous immunoglobulin secretion and autoantibody levels were markedly decreased after TLI in old NZB/NZW mice.
Fariñas
M C
MC
Department of Medicine, Stanford University School of Medicine, California 94305.
Strober
S
S
D000367:Age Factors; D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000528:radiation effects; D001323:Autoantibodies / Q000096:biosynthesis*; D002003:Brucella abortus / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000276:immunology*; D008221:Lymphoid Tissue / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D014301:Trinitrobenzenes / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D014301:Trinitrobenzenes