Chemical equivalence of two polyetherpolyurethane foams as a vehicle for povidone-iodine solution: kinetic model for the loss of available iodine.
The loss of available iodine from povidone-iodine solution stored in contact with two different polyetherpolyurethane foams was monitored as a function of time and temperature. Statistical evaluation of the results for the four temperatures studied [ambient (25 degrees), 30, 45 and 55 degrees C] indicated the chemical equivalence of the two foams as storage and delivery systems for povidone-iodine solution in terms of solution stability. In addition, application of a first-order kinetic model to the data produced an acceptable fit. An Arrhenius-type evaluation of the resulting rate constants yielded a linear relationship which was shown to be useful for predicting loss of available iodine under ambient temperature conditions of storage.
Mazzo
D J
DJ
Baxter Healthcare Corporation, Round Lake, IL 60073.
Bujak
T
T
Martin
R
R
D004355:Drug Stability; D006358:Hot Temperature; D007700:Kinetics; D008956:Models, Chemical; D014677:Pharmaceutical Vehicles; D011140:Polyurethanes / Q000737:chemistry*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000737:chemistry*
D014677:Pharmaceutical Vehicles; D011140:Polyurethanes; C115016:polyetherurethane; D011206:Povidone-Iodine