title: Cell surface expression of several species of human immunodeficiency virus type 1 major core protein.
abstract: The major core protein (p25) of the human immunodeficiency virus type 1 (HIV-1) was characterized by two-dimensional-gel isoelectric focusing. The p25 detectable in HIV-1-infected cells is composed of four species with related isoelectric points. This is due in part to the phosphorylated state of p25. The four species of p25 are expressed on the cell surfaces of infected cells, but only the two most basic species are incorporated into the HIV-1 virion. These findings emphasize the importance of p25 in understanding infection with HIV and might have implications for the development of vaccines.
authors.affiliation: Unité d'Oncologie Virale (URA 153 Centre National de la Recherche Scientifique), Institut Pasteur, Paris, France.
authors.forename: A G
authors.initials: AG
authors.lastname: Laurent
authors.forename: B
authors.initials: B
authors.lastname: Krust
authors.forename: M A
authors.initials: MA
authors.lastname: Rey
authors.forename: L
authors.initials: L
authors.lastname: Montagnier
authors.forename: A G
authors.initials: AG
authors.lastname: Hovanessian
mesh_terms: D000954:Antigens, Surface / Q000032:analysis; D002460:Cell Line; D000090266:Chromobox Protein Homolog 5; D015488:HIV Antigens / Q000032:analysis*; D016655:HIV Core Protein p24; D006801:Humans; D007525:Isoelectric Focusing; D008715:Methionine / Q000378:metabolism; D010766:Phosphorylation; D012191:Retroviridae Proteins / Q000032:analysis* / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; C000715594:CBX5 protein, human; D015488:HIV Antigens; D016655:HIV Core Protein p24; D012191:Retroviridae Proteins; D000090266:Chromobox Protein Homolog 5; D008715:Methionine