title: Specific cross-protection between Schistosoma bovis and S. haematobium induced by highly irradiated infections in mice.
abstract: Significant levels of resistance against Schistosoma haematobium challenge were developed by mice exposed to highly irradiated (20 krad) cercariae of the homologous species (46-53%) or of the closely related species, S. bovis (34-56%) but not of S. mansoni (-6-28%). This ability to cross-protect reflects the phylogenetic relationships between these species; S. mansoni and S. bovis, as well as S. mansoni and S. haematobium, failed to cross-protect. The cross-protection demonstrated between S. bovis and S. haematobium in mice was non-reciprocal.
authors.affiliation: Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Agnew
authors.forename: H M
authors.initials: HM
authors.lastname: Murare
authors.forename: M J
authors.initials: MJ
authors.lastname: Doenhoff
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D003429:Cross Reactions; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D012547:Schistosoma / Q000276:immunology*; D012548:Schistosoma haematobium / Q000276:immunology*; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology*; D012553:Schistosomiasis haematobia / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology; D013045:Species Specificity
chemical_list: D000947:Antigens, Helminth