title: Cardiac injury with damped sine and trapezoidal defibrillator waveforms.
abstract: To assess defibrillator-induced cardiac damage, 49 anaesthetized greyhounds received either no shocks (control group) or five shocks from a defibrillator delivering one of five waveforms (Lown, Edmark, Belfast damped sine waveforms: 5 and 20 ms trapezoidal waveforms). At 3 days the hearts of the 36 surviving dogs were examined for macroscopic damage. The Belfast and Edmark waveforms caused significantly more damage (mean 21.1 +/- SEM 2.9 g and 16.0 +/- 3.7 g) respectively than the Lown waveform (3.5 +/- 1.3 g) P less than 0.01. The 20 ms trapezoid caused significantly more damage (8.1 +/- 3.1 g) than the 5 ms pulse (0.7 +/- 1.3 g) P less than 0.05). The ventricular ectopic counts per minute were not significantly different in the three sine wave and 20 ms trapezoidal groups at 24 and 48 h (P greater than 0.05), but at 2 and 72 h were significantly greater in the Belfast and Edmark groups than in the Lown group (2 h, Belfast P less than 0.01, Edmark P less than 0.05: 72 h P less than 0.05). At 15 min there was more right chest ST-segment elevation in the Belfast than in the Lown, Edmark and 20 ms trapezoid groups (P less than 0.01), while left chest ST elevation was greater in the Belfast and Edmark than in the Lown (P less than 0.05) and 20 ms trapezoid groups (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, N. Ireland.
authors.forename: C M
authors.initials: CM
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Bailey
authors.forename: J D
authors.initials: JD
authors.lastname: Allen
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: A A
authors.initials: AA
authors.lastname: Adgey
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002307:Cardiography, Impedance; D004195:Disease Models, Animal; D004285:Dogs; D004554:Electric Countershock / Q000009:adverse effects* / Q000379:methods; D006335:Heart Injuries / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D013617:Tachycardia, Supraventricular / Q000209:etiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen