title: Preparation and care of the area postrema-lesioned cat.
abstract: The area postrema (AP) is being widely studied to delineate its role in such varied functions as blood pressure regulation, conditioned taste aversion, water and energy balance, and radiation-induced emesis. This paper describes the preoperative preparation, surgical procedure, and postoperative care of cats kept long-term in which the AP was lesioned by electrocautery. A dorsal midline approach under gas anesthesia allowed access to selectively lesion the AP. Cats fully regained consciousness the same day and many became homeostatic within 24-48 h. Results of experiments using this model demonstrate the usefulness and effectiveness of the technique for model preparation.
authors.affiliation: Armed Forces Radiobiology Research Institute, Division of Veterinary Medicine, Bethesda, MD 20814.
authors.forename: A L
authors.initials: AL
authors.lastname: Chedester
authors.forename: A C
authors.initials: AC
authors.lastname: Bakarich
authors.forename: B M
authors.initials: BM
authors.lastname: Rabin
authors.forename: R E
authors.initials: RE
authors.lastname: Banks
authors.forename: C L
authors.initials: CL
authors.lastname: Hadick
mesh_terms: D000818:Animals; D002415:Cats / Q000601:surgery*; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000503:physiopathology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D013525:Surgical Instruments; D014839:Vomiting / Q000503:physiopathology