Secretion of plasminogen activator in response to follicle-stimulating hormone in culture medium of human testicular cells from biopsy specimens.
Testicular cells from human biopsy specimens were cultured and plasminogen activator secreted into the medium was investigated. Follicle stimulating hormone stimulated plasminogen activator secretion. SDS-polyacrylamide gel electrophoresis followed by zymography showed that the molecular weight of plasminogen activator produced by human testicular cells is the same as that of human urokinase. Antigenicity was also found to be of the urokinase type but not of the tissue type.
Nishimune
Y
Y
Department of Science for Laboratory Animal Experimentation, Osaka University, Japan.
Sawada
K
K
Tajima
Y
Y
Watanabe
D
D
Maekawa
M
M
Sakamaki
K
K
Okuyama
A
A
Nakamura
M
M
Namiki
M
M
Matsumoto
K
K
D000328:Adult; D002478:Cells, Cultured; D003470:Culture Media / Q000032:analysis / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000032:analysis / Q000378:metabolism*; D013737:Testis / Q000166:cytology* / Q000378:metabolism / Q000502:physiology
D003470:Culture Media; D005640:Follicle Stimulating Hormone; D010960:Plasminogen Activators