title: Major surgery in von Willebrand's disease.
abstract: Two patients with von Willebrand's disease underwent major surgery, the first had aortic valve replacement and the second a total hip replacement. Clinically, the best practical test for monitoring the dose of cryoprecipitate necessary to maintain haemostasis was the bleeding time. The response to coagulation factor replacement in von Willebrand's disease is extremely variable, and it is necessary to maintain close coagulation monitoring until the patient's surgical condition is satisfactory for discharge from hospital.
authors.affiliation: Department of Haematology, Royal Postgraduate Medical School and Hammersmith Hospital, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Dokal
authors.forename: A
authors.initials: A
authors.lastname: Bradshaw
authors.forename: A
authors.initials: A
authors.lastname: Stoneham
authors.forename: S
authors.initials: S
authors.lastname: Bowcock
authors.forename: R
authors.initials: R
authors.lastname: Coombs
authors.forename: D
authors.initials: D
authors.lastname: Royston
authors.forename: K
authors.initials: K
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Hows
mesh_terms: D000368:Aged; D001021:Aortic Valve; D001705:Bioprosthesis; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000008:administration & dosage; D005260:Female; D005340:Fibrinogen / Q000008:administration & dosage; D006350:Heart Valve Prosthesis; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000097:blood
chemical_list: C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen