The bactericidal effect on Pseudomonas strains of adriamycin associated with quinolones.
The in vitro antibacterial activity of quinolone compounds was assessed on strains of Pseudomonas aeruginosa isolated from clinical infections. The bactericidal effect of quinolones was high and their respective antibacterial properties with adriamycin remained unimpaired on strains both sensitive and resistant to betalactam and aminoglycoside antibiotics. The cytotoxic effect of the combination of adriamycin and quinolones was determined in cultured P388 leukemia cells: no interference with the cytotoxic activity of adriamycin was observed.
Castelli
M
M
Istituto di Farmacologia dell' Università, Modena, Italia.
Baggio
G
G
Aresca
P
P
Bossa
R
R
Galatulas
I
I
D002939:Ciprofloxacin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009539:Nicotinic Acids / Q000494:pharmacology*; D009643:Norfloxacin / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*; D010876:Pipemidic Acid / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D009539:Nicotinic Acids; D002939:Ciprofloxacin; D004317:Doxorubicin; D015242:Ofloxacin; D010876:Pipemidic Acid; D009643:Norfloxacin