[Acute effects of a new type of lipidic emulsion in critical patients].
A new type of 10% lipidic emulsion based on safflower oil and soya (Liposyn II, Abbott, Latina) characterised by a high linoleic/linolenic acid ratio was administered in random, double blind fashion with 10% Intralipid to 20 subjects submitted to major surgery of the digestive system. Dosage was 1.2 g/kg at an infusion rate of 2.6 ml/kg/h. In order to evidence possible in vivo inter-reactions between proteins of the acute post-aggressive phase and these emulsions, serial samples were used to measure haemogasanalytic parameters, plasma levels of triglycerides and serum levels of protein C-reactive and fourth complement factor. Both emulsions proved well tolerated and there was no evidence of general or administrative site reactions. The plasma levels of triglycerides underwent an increase during the test, with no significant differences between the two groups of patients. Notwithstanding the high serum levels of protein C-reactive of the subjects in question, there was no evidence of activation of the complement system nor alteration in haemogasanalytic parameters with the two lipidic emulsions adopted.
Tomassetti
M
M
Celleno
D
D
Capogna
G
G
Reggio
S
S
D000368:Aged; D003167:Complement Activation / Q000187:drug effects; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011182:Postoperative Care; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011897:Random Allocation
D005217:Fat Emulsions, Intravenous
Effetti acuti di un nuovo tipo di emulsione lipidica in pazienti critici.