Clinical significance of urine ferritin determination in urologic malignancies.
Urine and serum ferritin levels were measured by a double-antibody radio-immunoassay in 96 normal adults and 57 patients with urologic malignancies. In the 96 adults, the urine ferritin levels ranged from 0 to 28 ng/ml. Elevated urine ferritin levels were observed in all 7 patients with renal pelvic carcinoma, 4 of 13 patients with renal carcinoma, 1 of 13 patients with well-differentiated (Grade I) bladder carcinoma, 8 of 19 patients with median-differentiated (Grade II) bladder carcinoma, and all 5 patients with poorly-differentiated (Grades III, IV) bladder carcinoma. These results indicated that urine ferritin assay was helpful in discriminating well-differentiated bladder carcinoma from the poorly-differentiated (P less than 0.01) in addition to differentiating renal pelvic carcinoma from renal carcinoma (P less than 0.05).
Tang
D J
DJ
Fan
X Y
XY
Huang
X B
XB
Chen
P H
PH
Liang
Y
Y
Lang
Y M
YM
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005293:Ferritins / Q000652:urine*; D006801:Humans; D007680:Kidney Neoplasms / Q000652:urine*; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D001749:Urinary Bladder Neoplasms / Q000652:urine*
D005293:Ferritins