Influence of 1 alpha,25-dihydroxyvitamin D3 on the development and steroid hormone receptor contents of DMBA-induced rat mammary tumors.
The influence of 1 alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the development and steroid hormone receptor contents of 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumors was evaluated. Neither the incidence nor the size of the tumors was affected by the 1,25-(OH)2D3 treatment (1 or 2 micrograms twice a week for 16 weeks) but estrogen and progesterone receptor contents of the tumors were significantly lower in 1,25-(OH)2D3-treated groups as compared to the control group. These results demonstrate that 1,25-(OH)2D3 at doses producing mild hypercalcemia does not affect the development of DMBA-induced rat mammary tumors but decreases the estrogen and progesterone receptor contents of the tumors.
Noguchi
S
S
Department of Surgery, Center for Adult Diseases, Osaka, Japan.
Tahara
H
H
Miyauchi
K
K
Koyama
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects; D010758:Phosphorus / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D010758:Phosphorus; D015127:9,10-Dimethyl-1,2-benzanthracene; D002117:Calcitriol; D002118:Calcium