Drug-induced inhibition of proteoglycanase activity in the Hulth-Telhag model.
Evidence has accumulated that there are increased degradative enzymes in osteoarthritis responsible for joint destruction. These enzymes are metal-dependent, and inhibited by EDTA. EDTA was administered intra-articularly to rabbits in an experimental model of osteoarthritis. There was a 25% reduction in neutral proteoglycanase activity and 75% of the animals had a reduction in the severity of the arthritis as measured on a histologic-histochemical grading system. It is suggested that future chemotherapeutic studies on arthritis might focus on enzyme inhibition.
Ishizue
K K
KK
Department of Orthopaedics, Massachusetts General Hospital, Boston.
Ehrlich
M G
MG
Mankin
H J
HJ
D000818:Animals; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D010450:Endopeptidases; D004791:Enzyme Inhibitors / Q000378:metabolism; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000473:pathology; D008666:Metalloendopeptidases; D008854:Microscopy, Electron; D010003:Osteoarthritis / Q000188:drug therapy* / Q000201:enzymology; D011480:Protease Inhibitors; D011817:Rabbits
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D004492:Edetic Acid; D010450:Endopeptidases; C022474:proteoglycan-degrading metalloendopeptidases; D008666:Metalloendopeptidases