title: [Attenuation of a strain of rinderpest virus: potential homologous live vaccine].
abstract: Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants frequently associated with severe mortality in these hosts. In countries where it occurs, PPR represents an important constraint to the improved productivity of sheep and goats. Until now the only way to combat this plague has been the use of heterologous rinderpest vaccine; all attempts to develop a homologous vaccine have ended in failure. The present communication describes the attenuation of the Nigerian strain PPRV Nig 75/1 by serial passage in Vero cells. The avirulent virus obtained has the same characteristics as Plowright and Ferris' rinderpest vaccine. The virus is advanced as a potential homologous vaccine against PPR.
authors.affiliation: Institut d'Elevage, Service de Pathologie Infectieuse, Maisons-Alfort, France.
authors.forename: A
authors.initials: A
authors.lastname: Diallo
authors.forename: W P
authors.initials: WP
authors.lastname: Taylor
authors.forename: P C
authors.initials: PC
authors.lastname: Lefèvre
authors.forename: A
authors.initials: A
authors.lastname: Provost
mesh_terms: D000818:Animals; D002417:Cattle; D005260:Female; D006041:Goats; D008297:Male; D012302:Rinderpest virus / Q000276:immunology* / Q000472:pathogenicity; D014765:Viral Vaccines; D014774:Virulence; D014776:Virus Cultivation / Q000379:methods
chemical_list: D014765:Viral Vaccines
vernacular_title: Atténuation d'une souche de virus de la peste des petits ruminants: candidat pour un vaccin homologue vivant.