title: Antimicrobial effectiveness of six paradols. 1: A structure-activity relationship study.
abstract: The pattern of antimicrobial effectiveness of (0)-, (2)-, (3)-, (4)-, (8)- and (9)-paradols was studied. (3)- Paradol was more active than the other homologues with a minimum inhibitory concentration (MIC) of 1 mg/ml when tested against Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus and Botryodiplodia theobromae. At 0.2 mg/ml, (3)-paradol completely inhibited the spore germination of Trichophyton mentagrophytes and after 3 h of exposure at 0.5 mg/ml, it inhibited the growth of a heavy inoculum of Staphylococcus aureus (1 X 10(9) cells/ml).
authors.affiliation: Department of Applied Microbiology, Ondo State University, Ado-Ekiti, Nigeria.
authors.forename: J K
authors.initials: JK
authors.lastname: Oloke
authors.forename: D O
authors.initials: DO
authors.lastname: Kolawole
authors.forename: W O
authors.initials: WO
authors.lastname: Erhun
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects; D010946:Plants, Medicinal; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; C013738:zingerone; D006139:Guaiacol