title: Early image acquisition after administration of indium-111 platelets in clinically suspected deep venous thrombosis.
abstract: Indium-111 platelet scintigraphy accurately detects acute deep venous thrombosis in asymptomatic high-risk patients and may be used as a surveillance test. However, its value in symptomatic patients and its accuracy early after platelet injection are not satisfactorily established. The latter is important for timely institution of therapy. Accordingly, 65 patients (67 limbs) with suspected deep venous thrombosis (symptom duration 8 +/- 10 days, mean +/- standard deviation) were prospectively studied with platelet scintigraphy and contrast venography. Platelets were labeled with 405 +/- 101 mCi indium-111 oxine. The labeling efficiency was 80 +/- 10%. All images were acquired within 120 minutes after intravenous administration of the platelet suspension. Both platelet scintigraphy and venography were interpreted independently by 2 blinded observers (for each technique). Five separate analyses were performed. Each scintigraphic reader was compared to each venographic reader. A fifth analysis--consisting of readings with blinded agreement of both readings of the platelet scans and both readings of the venograms--was performed. Interobserver agreement was 92% for venography and 79% for scintigraphy. Excluding anticoagulated patients, the sensitivity of platelet scintigraphy was between 38 and 46% and the specificity was between 92 and 100%. Thus, early imaging of labeled platelets for the diagnosis of symptomatic deep venous thrombosis carries a high specificity but a much lower sensitivity. It is speculated that the low sensitivity is related to the inactivity of the thrombus. This may suggest that early imaging will only be useful in patients whose symptoms are of recent onset.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: D C
authors.initials: DC
authors.lastname: Farlow
authors.forename: M D
authors.initials: MD
authors.lastname: Ezekowitz
authors.forename: S R
authors.initials: SR
authors.lastname: Rao
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.forename: D F
authors.initials: DF
authors.lastname: Denny
authors.forename: S S
authors.initials: SS
authors.lastname: Morse
authors.forename: J S
authors.initials: JS
authors.lastname: Decho
authors.forename: F
authors.initials: F
authors.lastname: Wackers
authors.forename: E
authors.initials: E
authors.lastname: Strauss
mesh_terms: D001792:Blood Platelets; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D010690:Phlebography; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*; D013997:Time Factors
chemical_list: D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline