title: [Multidisciplinary protocol for the treatment of epidermoid carcinoma of the esophagus: experience from 1985 to 1989].
abstract: A phase II study activated in 1985 for the multidisciplinary treatment of squamous cell carcinoma of the esophagus is described. The treatment program included simultaneous neoadjuvant continuous infusion chemotherapy with cisplatinum and 5-fluorouracil, preoperative radiotherapy (46 Gy in 5 weeks) and delayed programmed surgery (or radical irradiation in selected cases). Twenty-one patients with tumor stages I (6), II (10), III (5) entered in the study and 20 patients completed the treatment program. Severe toxicity observed was: esophagitis 100%, bone marrow aplasia 30%, severe weight loss 52%. One patient developed a tracheo-esophageal fistula at the end of radiotherapy. Clinical objective tumor response rate was 85%. Pathologic complete tumor response rate was 47%. Median follow-up of the entire group is 11 months (range 2 + to 49 + months). Ten patients have been alive for more than 12 months; six are still alive without any evidence of disease (from 12 + to 49 + months). It is concluded that the protocol described is feasible, with treatment related severe but reversible toxicities, and able to induce a high rate of tumor response and long term survivors in patients with initial locally advanced tumor stages.
authors.affiliation: Dpto. de Oncología, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra.
authors.forename: O
authors.initials: O
authors.lastname: Abuchaibe
authors.forename: J L
authors.initials: JL
authors.lastname: Hernández Lizoáin
authors.forename: O
authors.initials: O
authors.lastname: Fernández Hidalgo
authors.forename: G
authors.initials: G
authors.lastname: Zornoza
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Voltas
authors.forename: F A
authors.initials: FA
authors.lastname: Calvo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
vernacular_title: Protocolo multidisciplinar de tratamiento del carcinoma epidermoide de esófago: experiencia 1985-1989.