Natural occurrence of IgE antibodies to peptide hormones in man.
IgE antibodies to peptide hormones or their fragments were investigated using specific radioallergosorbent tests. Ninety-six sera were obtained from otherwise healthy individuals with a positive RAST to at least one common allergen and without previous contact to exogenous hormones. Total serum IgE was normal (less than 300 ng ml-1) in 41 and elevated in 55 sera. Only one serum with normal total IgE had reagins to proinsulin. In sera with elevated total IgE positive tests (greater than 8 x background) were observed frequently: hGH 9.1%, GHRH1-44 5.5%, GHRH1-29 12.7%, erythropoietin 10.9%, human calcitonin 14.6%, salmon calcitonin 1.8%, ACTH 5.5%, insulin 14.6%, proinsulin 7.3%, insulin A chain 1.8%, insulin B chain 18.2, C-peptide 9.1%, and IGF 9.1%. The data show natural occurrence of reagins to peptide hormones in atopic persons. A risk at exposure to these peptides may exist in about 1% of the general population.
Khalaf
A N
AN
Department of Endocrinology, University Hospital of Internal Medicine, Freiburg, FRG.
Kerp
L
L
Schliebs
B
B
Jägle
M
M
Petersen
K G
KG
D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006728:Hormones / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D010446:Peptide Fragments / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D011852:Radioallergosorbent Test; D011935:Reagins / Q000032:analysis
D001323:Autoantibodies; D006728:Hormones; D010446:Peptide Fragments; D010455:Peptides; D011935:Reagins; D007073:Immunoglobulin E