title: Validation of pH dataloggers for pharmacologic studies.
abstract: Twenty-four-hour gastric aspiration studies have been superseded by dataloggers that continuously record intragastric pH. We have studied both techniques in a practical pharmacologic study, comparing early evening versus nighttime dosing with ranitidine and nizatidine against placebo. Whereas there was a highly significant point correlation between aspiration and datalogger pH, the slope was significantly less than 1. The correlation was poorer during the day (r = 0.51) than at night (r = 0.83). Irrespective of the techniques used, however, conclusions reached on drug efficacy were similar, but direct comparison of data from the two techniques is not possible.
authors.affiliation: Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada.
authors.forename: S G
authors.initials: SG
authors.lastname: Chiverton
authors.forename: D W
authors.initials: DW
authors.lastname: Burget
authors.forename: R H
authors.initials: RH
authors.lastname: Hunt
mesh_terms: D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D001330:Electronic Data Processing; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016567:Nizatidine; D011897:Random Allocation; D011899:Ranitidine / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013844:Thiazoles; D011899:Ranitidine; D016567:Nizatidine