title: Acanthamoeba keratitis: report of three cases.
abstract: During the last year we diagnosed three patients to have Acanthamoeba keratitis. In one patient, who wore soft contact lenses, keratitis had developed after swimming in a contaminated heated swimming pool. Neither a history of trauma was present in two other patients nor did they wear contact lenses. Diagnosis of Acanthamoeba was established by Calcofluor White (cellufluor) staining of the scraped corneal material. Patients were treated with Flagyl (metronidazole) 0.5% eyedrops, Brolene (propamidine isethionate) 0.1% eyedrops, Neomycin eyedrops, topical corticosteroids (including sustain-release corticosteroid subconjunctival injections) and mydriatics. Keratitis in one patient healed within one month with full visual recovery, whereas the disease nearly ameliorated in the second patient. Corneal inflammation subsided markedly in the third patient with medical therapy, but a keratoplasty had to be performed because of a central opaque and ectatic cornea. This patient had already developed severe keratitis with necrosis of the cornea at the time of diagnosis.
authors.forename: P C
authors.initials: PC
authors.lastname: Maudgal
mesh_terms: D015823:Acanthamoeba Keratitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D001550:Benzamidines / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D009355:Neomycin / Q000008:administration & dosage
chemical_list: D000305:Adrenal Cortex Hormones; D000981:Antiprotozoal Agents; D001550:Benzamidines; D008795:Metronidazole; C046651:propamidine isethionate; D009355:Neomycin