[Cross-reactivity between major histocompatibility complex class II antigens in mice NOD and an islet antigen with 58 kDA molecular weight].
The NOD mouse has been recently developed as a model for autoimmune insulin-dependent diabetes mellitus. The NOD mouse is further characterized by a genetic linkage with genes mapping within the major histocompatibility complex at the I-A locus. The present work demonstrates the presence in NOD mice of circulating autoantibodies specific for a 58 kDa antigen which is present in membrane extracts prepared from the murine insulin-secreting tumoral cell line Rin5F. This 58 kDa antigen shows a cross reactivity with NOD mouse class II antigens as indicated by its recognition by anti-I-A(NOD) monoclonal antibodies.
Boitard
C
C
Hôpital Necker, Paris.
Pham-Gia
H
H
Becourt
C
C
Bach
J F
JF
D000818:Animals; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D003429:Cross Reactions; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight
D000941:Antigens; D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II
Réaction croisée entre les antigènes de classe II du complexe majeur d'histocompatibilité de la souris NOD et un antigène insulaire de poids moléculaire de 58 kDa.