title: Autoinduction of hypertensive reactions by tranylcypromine?
abstract: Although rarely described in the psychiatric literature, patients treated with monoamine oxidase inhibitors may experience acute hypertensive reactions that are not readily attributable to dietary indiscretion or use of concomitant medications. Four cases of apparent autoinduction of hypertensive reactions in patients receiving tranylcypromine are presented. The mechanism of this reaction is unknown, but may involve conversion of tranylcypromine to metabolites with pressor activity.
authors.affiliation: Laboratories for Psychiatric Research, Mailman Research Center, Belmont, Massachusetts.
authors.forename: P E
authors.initials: PE
authors.lastname: Keck
authors.forename: H G
authors.initials: HG
authors.lastname: Pope
authors.forename: A A
authors.initials: AA
authors.lastname: Nierenberg
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002032:Bulimia / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D014191:Tranylcypromine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014191:Tranylcypromine