title: [54 cases of infectious endocarditis seen in 32 years in a population of 2038 congenital heart diseases].
abstract: A longitudinal study of a 32-year period (1954-1987) involving 2038 patients with congenital heart defects followed by the same physician yielded 54 cases of infective endocarditis (IE). Complex cyanogenic cardiopathies were particularly exposed to the risk of infection (8.2 IE for 1000 patient-years), then came ventricular septal defects (2.4), tetralogy of Fallot (2.3), aortic stenosis (2.0) and atrioventricular canal (1.7). The risk was smaller in patients with Eisenmerger complex (1.2), persistent arterial canal (1.4) and coarctation (0.7). Patients under 10 years of age (16.7%) were less affected than young adults in the 20-29 years age-group (33.4%). The organisms most frequently isolated were streptococci (42%); staphylococci ranked second (23%). Less common organisms were found in 14% of the cases, and blood cultures were negative in 21%. Systemic prophylaxis with penicillin V, introduced 16 years ago, seems to have almost halved the incidence of infective endocarditis due to penicillin-sensitive organisms.
authors.affiliation: Consultation de médecine, Groupe hospitalier Pitié-Salpêtrière, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Corone
authors.forename: A
authors.initials: A
authors.lastname: Lévy
authors.forename: P
authors.initials: P
authors.lastname: Hallali
authors.forename: A
authors.initials: A
authors.lastname: Davido
authors.forename: Y
authors.initials: Y
authors.lastname: Wyler
authors.forename: A
authors.initials: A
authors.lastname: Corone
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004697:Endocarditis, Bacterial / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D010404:Penicillin V / Q000627:therapeutic use; D011379:Prognosis; D013290:Streptococcal Infections / Q000453:epidemiology
chemical_list: D010404:Penicillin V
vernacular_title: A propos de 54 cas d'endocardites infectieuses observées en 32 ans sur une population de 2,038 cardiopathies congénitales.