title: Postoperative adjuvant external-beam radiotherapy in surgical stage I endometrial carcinoma.
abstract: A combined surgical and radiotherapeutic approach is widely in Stage I endometrial adenocarcinoma. The technique and timing of the radiotherapy varies from center to center. Postoperative external-beam (EB) radiotherapy has the advantage of patient selection based upon surgical findings, comprehensive treatment of the pelvic nodal and vaginal cuff areas, and elimination of the need for an intracavitary procedure. Although frequently utilized, this technique is surprisingly poorly described in the medical literature. From 1979 to 1986, 46 surgical Stage I patients received adjuvant postoperative EB therapy at Georgetown University Hospital (GUH) (Washington, DC). Indications for treatment were Grade greater than or equal to 2 and/or depth of myometrial invasion of greater than 33%. The 5-year actuarial survival was 90% with a disease-free survival of 82%. The failure rate within the irradiated field was 6.5% with a distant failure rate of 8.7%. The rate of significant long-term complications was acceptable at 6.5%. The authors conclude that postoperative EB radiotherapy is an effective adjuvant therapy with results comparable to other available radiotherapeutic techniques.
authors.affiliation: Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20007.
authors.forename: J R
authors.initials: JR
authors.lastname: Torrisi
authors.forename: W A
authors.initials: WA
authors.lastname: Barnes
authors.forename: G
authors.initials: G
authors.lastname: Popescu
authors.forename: G
authors.initials: G
authors.lastname: Whitfield
authors.forename: J
authors.initials: J
authors.lastname: Barter
authors.forename: G
authors.initials: G
authors.lastname: Lewandowski
authors.forename: G
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011182:Postoperative Care; D011882:Radiotherapy, High-Energy; D014594:Uterine Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery