title: Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats.
abstract: Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.
authors.affiliation: Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210-1228.
authors.forename: S C
authors.initials: SC
authors.lastname: Dilsaver
authors.forename: H J
authors.initials: HJ
authors.lastname: Normile
authors.forename: H J
authors.initials: HJ
authors.lastname: Altman
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D004357:Drug Synergism; D008297:Male; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D010133:p-Chloroamphetamine / Q000633:toxicity
chemical_list: D000928:Antidepressive Agents; D010095:Oxotremorine; D010133:p-Chloroamphetamine; C025293:alaproclate; D000409:Alanine