Arthropathy associated with Brucella abortus strain 19 vaccination in cattle. II. Experimental studies.
Attempts to reproduce in calves the arthropathy associated with Brucella abortus strain 19 (S19) vaccination by direct intra-articular injection of S19 or virulent Brucella cells were unsuccessful. Intra-articular injection of rabbits and a calf with immune complexes isolated from the synovial fluid of a field case produced clinical and histological signs of arthropathy accompanied by the development of rheumatoid factor.
Corbel
M J
MJ
Stuart
F A
FA
Brewer
R A
RA
Jeffrey
M
M
Bradley
R
R
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D002004:Brucella Vaccine / Q000009:adverse effects*; D002003:Brucella abortus / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000276:immunology; D007592:Joint Diseases / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D007794:Lameness, Animal / Q000209:etiology / Q000276:immunology; D011817:Rabbits; D012217:Rheumatoid Factor / Q000032:analysis; D013582:Synovial Fluid / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology; D014611:Vaccination / Q000662:veterinary
D000936:Antigen-Antibody Complex; D002004:Brucella Vaccine; D012217:Rheumatoid Factor