[Studies on the stability and some other important physical properties of polysaccharides polyphase liposome (PPL)].
The stability and some other important physical properties of PPL were investigated by means of electron microscopy and MPV-TAS experiments. The results are rated as follows: Good integrity of liposome homogeneity of its particle size were reached, and at 100 degrees C PPL was found to undergo sterilization without causing changes of its shape and encapsulation efficiency for 1 h. Also, the distribution of PPL particle size and the regularity of the change of PPL particle in size were determined by Coulter counter. Using this method, the kinetic equation of coalescence of polyphase liposome and the activation energy for coalescence were obtained, and through these results the stability of PPL is elucidated.
Zou
Y Y
YY
Su
D S
DS
Han
G C
GC
Gu
X Q
XQ
D004337:Drug Carriers; D004355:Drug Stability; D008081:Liposomes; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D010316:Particle Size; D011134:Polysaccharides
D004337:Drug Carriers; D008081:Liposomes; D008937:Mitomycins; D011134:Polysaccharides; D016685:Mitomycin