[The significance of analysis and detection of Bence Jones protein in the urine in clinical laboratory diagnosis].
Bence Jones proteins (monoclonal free light-chains of immunoglobulins) are the earliest known biologic markers of malignant plasma cell dyscrasia, but Bence Jones proteinuria is also found in many types of B-cell related neoplasms. In some cases it may occur in Hodgkin disease. In some cases benign monoclonal gammopathy related to non-tumor conditions was found. The type of the monoclonal light-chain, the polymerisation and the isoelectric point of the molecules are considerable factors in the development of the disease. Urine specimens from 637 patients with (or suspected) lymphoproliferative diseases were investigated in a two year period using different immunochemical methods. Bence Jones proteinuria was found in 71 cases with the new method (isoelectric focusing combined with immunofixation) and 63 cases by the conventional ones. Bence Jones proteins can be detected by this new method at level below the sensitivity of conventional procedures. Bence Jones proteins in the urine may call the attention to the malignant tumor or the malignant transformation of the disease. The early detection of the monoclonal light-chain excretion may be important in the respect of clinical diagnosis, therapy and the follow-up the clinical status of the patient.
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D000911:Antibodies, Monoclonal / Q000276:immunology; D001536:Bence Jones Protein / Q000652:urine*; D006689:Hodgkin Disease / Q000276:immunology / Q000652:urine*; D006801:Humans; D007120:Immunochemistry; D007147:Immunoglobulin Light Chains / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology / Q000652:urine*; D011507:Proteinuria
D000911:Antibodies, Monoclonal; D007147:Immunoglobulin Light Chains; D001536:Bence Jones Protein
A vizelet Bence Jones fehérje kimutatásának és vizsgálatának jelentösége a klinikai laboratóriumi diagnosztikában.