title: Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein.
abstract: Sequencing cDNA and genomic DNA from the ovarian tumor gene revealed a gene with seven introns spanning 4.5 kilobases. The proline-rich, hydrophilic otu protein is novel. An antibody prepared to a beta-gal-otu fusion protein recognized a 110-kilodalton ovarian protein which was altered in the ovaries of otu gene mutants.
authors.affiliation: Department of Biochemistry, University of North Carolina, Chapel Hill 27599.
authors.forename: W R
authors.initials: WR
authors.lastname: Steinhauer
authors.forename: R C
authors.initials: RC
authors.lastname: Walsh
authors.forename: L J
authors.initials: LJ
authors.lastname: Kalfayan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex / Q000032:analysis; D001483:Base Sequence; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005091:Exons; D005260:Female; D015723:Gene Library; D007301:Insect Hormones; D007438:Introns; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009154:Mutation; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000235:genetics*; D015183:Restriction Mapping
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D029721:Drosophila Proteins; D007301:Insect Hormones; C061992:otu protein, Drosophila