Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP).
Heparin-induced Extracorporeal LDL-Precipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range less than 5%) was observed. Long-term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibialis anterior in five patients before and after a single HELP treatment increased from 30 +/- 4 to 37 +/- 7 mmHg and from 27 +/- 2 to 31 +/- 3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.
Schuff-Werner
P
P
Department of Clinical Chemistry, University Clinics, Goettingen, FRG.
Schütz
E
E
Seyde
W C
WC
Eisenhauer
T
T
Janning
G
G
Armstrong
V W
VW
Seidel
D
D
D000328:Adult; D001809:Blood Viscosity; D011232:Chemical Precipitation; D003327:Coronary Disease / Q000097:blood / Q000628:therapy*; D004903:Erythrocyte Aggregation; D005112:Extracorporeal Circulation; D005260:Female; D005340:Fibrinogen / Q000502:physiology*; D006493:Heparin; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D010101:Oxygen Consumption; D012212:Rheology
D008077:Lipoproteins, LDL; D005340:Fibrinogen; D006493:Heparin