title: [A multicenter comparative study in patients with liver metastasis to compare tegafur in new forms with existing drugs. SF-RC.SF-SP Comparative Study Group].
abstract: A multicenter comparative study was carried out in 101 patients with liver metastasis to compare tegafur in a new oral form (Sunfural S) and tegafur in a new soft-capsule suppository form (Sunfural Rectal Capsules) with existing drugs. Sunfural S showed a tendency toward high plasma and tissue levels as compared to existing drugs, and clinically, Sunfural S produced survival times that surpassed those of existing drugs. Liver metastasis at the present time has few effective treatments, but we expect that anticancer effects will be obtained through the administration of new drugs with improved bioavailability.
authors.affiliation: Jichi Medical Schoool.
authors.forename: A
authors.initials: A
authors.lastname: Kashii
authors.forename: H
authors.initials: H
authors.lastname: Kogure
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001682:Biological Availability; D002214:Capsules; D003110:Colonic Neoplasms; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D013274:Stomach Neoplasms; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D002214:Capsules; D013488:Suppositories; D005641:Tegafur