[Retrospective evaluation of the efficacy of regional endolymphatic polychemotherapy in kidney cancer depending on the histologic structure of the tumor].
An attempt was made to differentiate the prognosis for patients with various histological patterns of renal cell carcinoma subjected to adjuvant regional endolymphatic polychemotherapy from those patients who were not. A total of 90 patients were allocated to 3 groups: the first group consisted of those persons for whom a 4-component endolymphatic therapy with 5-fluorouracil, cyclophosphamide, methotrexate, thiotepa was employed; the second group (25 patients) was administered the same preparations intravenously; the third-group patients (25 subjects) were those who after surgery were not given drugs at all. Tumor biopsy specimens were studied in detail histologically and 3 carcinoma patterns were distinguished: clear cell, granular cell and anaplastic carcinoma. The number of mitotic figures per 1,000 tumor cells was defined as well. The life-span of all anaplastic carcinoma patients was less than 5 yrs. Three-year survival was the most common in first group patients with clear cell or granular cell carcinomas. Five-year survival in patients with granular cell carcinoma was 50 per cent in the first and 11.1 per cent in the second group, while in those with clear cell carcinoma it was relatively equal in all groups. The total five-year survival rate was 40 per cent in group I, 20 per cent in group II and 16 per cent in group III. The results obtained were indicative of a higher effect of adjuvant endolymphatic polychemotherapy versus intravenous treatment. As better results were in those with granular cell carcinoma than in patients with clear cell carcinoma, tumor histological pattern be considered before the adjustment of cytostatic dosages and disease prognostication.
Serniak
P S
PS
Shlopov
V G
VG
Vlodavskiĭ
E A
EA
Geev
Iu V
IuV
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007272:Injections, Intralymphatic; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009392:Nephrectomy; D011182:Postoperative Care; D011379:Prognosis; D012189:Retrospective Studies; D013852:Thiotepa / Q000008:administration & dosage
D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil; D008727:Methotrexate
Retrospektivnaia otsenka éffektivnosti regionarnoĭ éndolimfaticheskŏi polikhimioterapii pri rake pochki v zavisimosti ot gistologicheskogo stroeniia opukholi.