Biological activities of synthetic polypeptides containing a repetitive core sequence (Arg-Gly-Asp) of cell adhesion molecules.
A unique polypeptide containing the repeated structure of core sequence from cell adhesion molecules, poly(Arg-Gly-Asp), was successfully prepared by the polymerization procedure with diphenylphosphoryl azide. This polypeptide dramatically inhibited the aggregation of platelets induced by adenosine diphosphate (ADP) or malignant melanoma cells.
Saiki
I
I
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Iida
J
J
Azuma
I
I
Nishi
N
N
Matsuno
K
K
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000595:Amino Acid Sequence; D015815:Cell Adhesion Molecules / Q000737:chemistry*; D006801:Humans; D008545:Melanoma; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D015815:Cell Adhesion Molecules; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate