title: Routine prenatal screening policy of fetal malformations by both maternal serum alpha-fetoprotein and ultrasound in eastern Hungary.
abstract: Since January 1979, at our Genetic Counselling Unit in Debrecen all pregnancies at high risk for any reason have been screened sequentially by serum alpha-fetoprotein estimation (at the 16th week) and by ultrasound examination (18th week). This screening policy covered 1200-1500 consultations per year. From July 1983, the same prenatal screening policy has been extended to cover the whole pregnant population of two large counties in Eastern Hungary. In a six-year period over 300 fetal malformations were diagnosed. Details of the screening policy and the main groups of malformations diagnosed prenatally are demonstrated.
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical School of Debrecen, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Szabó
authors.forename: Z
authors.initials: Z
authors.lastname: Tóth
authors.forename: O
authors.initials: O
authors.lastname: Török
authors.forename: L
authors.initials: L
authors.lastname: Veress
authors.forename: E
authors.initials: E
authors.lastname: Bede
authors.forename: E
authors.initials: E
authors.lastname: Nagy
authors.forename: Z
authors.initials: Z
authors.lastname: Papp
mesh_terms: D000013:Congenital Abnormalities / Q000517:prevention & control*; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D005817:Genetic Counseling; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008403:Mass Screening; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012307:Risk Factors; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins