[Preliminary study of the use of intranasal buserelin in the long-term protocol of ovarian stimulation with the view toward fertilization in vitro].
A study conducted in 22 patients who used intranasal buserelin, in a long-term protocol for IVF, showed that pituitary desensitization is obtained between 14 days and 1 month. Analysis of the trials in this series, where the results were not satisfactory, suggests that the bioavailability of the product used intranasally, may be in question. A better distribution of nasal sprays causes more discomfort than when used subcutaneously.
Camier
B
B
Centre de Gynécologie-Obstétrique, CHU, Amiens.
Gagneur
O
O
Arlot
S
S
Thépot
F
F
Vitse
M
M
D000281:Administration, Intranasal; D001682:Biological Availability; D002064:Buserelin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*
D002064:Buserelin
Etude préliminaire de l'utilisation de la busereline par voie nasale dans le protocole long de stimulation ovarienne en vue de fécondation in vitro.