[Primary macroglobulinemia with severe neutropenia, leading to a rapid development of septic shock].
A 88-year-old man was admitted because of the left chest pain due to herpes zoster for 1 week. Blood analyses and immunoelectrophoresis revealed anemia, severe neutropenia, rouleaux formation and IgM, lambda-type monoclonal gammopathy. The HE staining and peroxidase-anti-peroxidase staining of biopsy specimens of the cervical lymph node swelling appeared from the fifth hospital day, revealed an increase in atypical lymphocytes bearing IgM, lambda-type immunoglobulin. Then a diagnosis of primary macroglobulinemia was made. Although the patient's clinical findings transiently improved after chemotherapy with prednisolone and vindesine, he died of a septic shock which appeared after klebsiella pneumonia and sepsis. We reported an unusual case of primary macroglobulinemia with severe neutropenia, leading to a rapid development of septic shock after the chemotherapy.
Umeki
S
S
Shibayama
T
T
Izumi
K
K
Sezaki
T
T
D000368:Aged; D000369:Aged, 80 and over; D000380:Agranulocytosis / Q000150:complications*; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D008297:Male; D009503:Neutropenia / Q000150:complications*; D012772:Shock, Septic / Q000209:etiology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology
D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains