Inhibition of human placenta aldose reductase by tannic acid.
Tannic acid was found to be a highly potent inhibitor of human placenta aldose reductase. The most potent inhibitory component of the tannic acid was isolated and identified as penta-O-galloyl-beta-D-glucose, which showed an IC50 value of 70 nM. The inhibition by the gallotannin was reversible and of mixed type with respect to DL-glyceraldehyde as the varied substrate.
Sawada
H
H
Hamatake
M
M
Hara
A
A
Nakagawa
M
M
Nakayama
T
T
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D066298:In Vitro Techniques; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013634:Tannins / Q000494:pharmacology*
D047348:Hydrolyzable Tannins; D013634:Tannins; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase