Pancreatic glucagon does not alter intrameal gastric emptying of milk in the rat.
The hypothesis that pancreatic glucagon (PG) inhibits feeding by altering intrameal gastric emptying was tested in nondeprived rats at midday, conditions under which exogenous PG is thought to elicit satiety. Rats received intraperitoneal injections of PG (400 or 800 micrograms/kg), cholecystokinin (CCK, 0.5 or 1.0 micrograms/kg) or saline and were given bolus intragastric infusions of 10 ml evaporated milk through chronic gastric cannulae. PG did not affect volumes of stomach contents recovered 20 minutes postinjection. In contrast, CCK inhibited gastric emptying in a dose-related manner. When milk was offered to the same rats to drink, 400 micrograms/kg PG significantly reduced meal size. These findings suggest that PG's satiety effect is not caused by its effect on stomach emptying.
Stockinger
Z
Z
Psychology Department, Columbia University, New York, NY 10027.
Geary
N
N
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004750:Enteral Nutrition; D005247:Feeding Behavior / Q000187:drug effects*; D005746:Gastric Emptying / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D008297:Male; D008892:Milk; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*
D005934:Glucagon; D002766:Cholecystokinin