Effect of moderate weight loss on prolactin secretion in normal female volunteers.
Sleep-related prolactin secretion and prolactin responses to the infusion of low doses of the dopamine antagonist, metoclopramide, and thyrotropin-releasing hormone were measured in 11 female volunteers before and after undertaking a diet in which they lost a mean of 3.1 kg in weight in 3 weeks. No effect of weight loss on these measures was found, but there was a significant, although modest, reduction in fasting plasma tryptophan concentration without any change in the concentration of competing amino acids.
Anderson
I M
IM
Oxford University Department of Psychiatry, U.K.
Crook
W S
WS
Gartside
S E
SE
Parry-Billings
M
M
Newsholme
E A
EA
Cowen
P J
PJ
D000328:Adult; D000596:Amino Acids / Q000097:blood; D015992:Body Mass Index; D002940:Circadian Rhythm; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008787:Metoclopramide; D011388:Prolactin / Q000097:blood*; D012894:Sleep Stages / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone; D014364:Tryptophan / Q000097:blood; D015431:Weight Loss
D000596:Amino Acids; D013973:Thyrotropin-Releasing Hormone; D014364:Tryptophan; D011388:Prolactin; D008787:Metoclopramide