Effects of midazolam on fentanyl antinociception and respiration in a rabbit model.
Clinical antinociception is difficult to assess because of difficulties with controls and the incorporation of bias. The rabbit antinociceptive model is highly sensitive and predictive of analgesia in humans. We found that the combination of midazolam with fentanyl enhanced antinociception compared with fentanyl alone. In addition, with this model there were relatively unimportant increases in respiratory depression.
Hyatt
J
J
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Coro
C
C
Bergman
S A
SA
Wynn
R L
RL
D000700:Analgesics; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004338:Drug Combinations; D004558:Electric Stimulation; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000139:chemically induced
D000700:Analgesics; D004338:Drug Combinations; D002245:Carbon Dioxide; D009270:Naloxone; D008874:Midazolam; D005283:Fentanyl