title: Transcutaneous and liver surface PO2 during hemorrhagic hypotension and treatment with phenylephrine.
abstract: Transcutaneous PO2 (PtcO2) and liver surface PO2 (PIO2) were measured in six mongrel dogs during hemorrhagic shock, normotensive shock, and volume resuscitation. Normotension was produced during extreme hypovolemia by an infusion of phenylephrine. PtcO2 and PlO2 were compared to each other and to hemodynamic and oxygen transport variables. PtcO2 and PlO2 correlated well with cardiac index (CI) r = .71 and .86, respectively; n = 60) and with each other (r = .79; n = 60). Heart rate, mean arterial pressure (MAP), and PaO2) correlated less with PtcO2 or PlO2. During the normotensive shock period, PtcO2, PIO2, CI, oxygen delivery (DO2), and oxygen consumption (VO2) were all severely decreased, while PaO2 and MAP were normal and lactic acid concentrations were elevated. It was concluded that PtcO2 follows changes in PlO2 during hypotensive and normotensive low cardiac output shock in mongrel dogs. Low PtcO2 values are associated with low values of PlO2, DO2, VO2, and rising lactic acid concentrations in dogs. These animal data imply that low PtcO2 values encountered in clinical monitoring during anesthesia and surgery may correspond to decreased blood volume, blood flow, and PlO2.
authors.affiliation: Department of Anesthesiology, University of California, Irvine, Medical Center, Orange 92668.
authors.forename: K K
authors.initials: KK
authors.lastname: Tremper
authors.forename: S J
authors.initials: SJ
authors.lastname: Barker
authors.forename: S M
authors.initials: SM
authors.lastname: Hufstedler
authors.forename: M
authors.initials: M
authors.lastname: Weiss
mesh_terms: D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010656:Phenylephrine / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D002245:Carbon Dioxide; D010656:Phenylephrine; D010100:Oxygen