Metabolic disturbances after coronary occlusion.
In addition to the loss of oxygen supply and oxidative metabolism, a lack of coronary flow causes abnormalities of glycolytic anaerobic metabolism and associated ion fluxes. During reperfusion, the accumulation of massive amounts of calcium appears to contribute significantly to irreversible myocardial damage. The implications of these observations are discussed.
Neely
J R
JR
Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, Pa.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D005227:Fatty Acids / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000150:complications / Q000378:metabolism; D007773:Lactates / Q000097:blood; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000517:prevention & control*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D005227:Fatty Acids; D007773:Lactates; D000255:Adenosine Triphosphate; D002118:Calcium