title: Postoperative radiotherapy and late mortality: evidence from the Cancer Research Campaign trial for early breast cancer.
abstract: OBJECTIVE
  To identify any excess mortality caused by adjuvant radiotherapy for early breast cancer.
  
  
  METHODS
  Prospective randomised clinical trial. Two thousand subjects needed for study to have a 90% chance of detecting a difference in survival rate of 7% with 95% significance. Patients were followed up until June 1988, giving follow up of 158-216 months.
  
  
  METHODS
  A multicentre trial mainly drawing patients from centres in the United Kingdom.
  
  
  METHODS
  2800 Women presenting with clinical stage I or II carcinoma of the breast from June 1970 to April 1975.
  
  
  METHODS
  One group of women (n = 1376) had simple mastectomy followed by immediate postoperative radiotherapy (1320 to 1510 rets). The remaining women (n = 1424) had simple mastectomy with subsequent careful observation of the axilla, radiotherapy being delayed until there was obvious progression or recurrence of disease locally.
  
  
  METHODS
  Increased mortality in patients treated with radiotherapy from causes other than breast cancer.
  
  
  RESULTS
  Survival was measured from time of first treatment to death or last follow up. Deaths from any cause and from specified causes were counted as events. Comparison over the whole follow up showed a slight excess mortality in the group treated with radiotherapy (relative risk 1.04; 95% confidence interval 0.94 to 1.15). The relative risk of death from breast cancer was 0.97 (0.87 to 1.08) but that of death from other causes was 1.37 (1.09 to 1.72), the increase mainly being in women who had had tumours of the left breast (1.61 (1.17 to 2.24)) and had been treated with orthovoltage (1.85 (1.27 to 2.71)). Analysis of causes of death after five years showed a relative risk of 2.11 (1.25 to 3.59) for new malignancies and of 1.65 (1.05 to 2.58) for cardiac disease, the increase in cardiac mortality being most pronounced in patients who had had tumours of the left breast and whose treatment had included orthovoltage radiation (relative risk 2.67 (1.28 to 5.55)).
  
  
  CONCLUSIONS
  Adjuvant radiotherapy after simple mastectomy for early breast cancer produces a small excess late mortality from other cancers and cardiac disease. The risk has to be balanced against the higher risk of local recurrence when immediate postoperative radiotherapy is not given. The balance has to be assessed for each patient, and for many patients radiotherapy will still be desirable in the initial treatment of their early breast cancer.
authors.affiliation: Medical Research Council Trials Office, Cambridge.
authors.forename: J L
authors.initials: JL
authors.lastname: Haybittle
authors.forename: D
authors.initials: D
authors.lastname: Brinkley
authors.forename: J
authors.initials: J
authors.lastname: Houghton
authors.forename: R P
authors.initials: RP
authors.lastname: A'Hern
authors.forename: M
authors.initials: M
authors.lastname: Baum
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D002423:Cause of Death; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D015337:Multicenter Studies as Topic; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects*; D011897:Random Allocation; D012307:Risk Factors; D013997:Time Factors