Pharmacokinetics of rioprostil in rats.
The pharmacokinetics of rioprostil in rats has been investigated following a single intravenous or oral dose of rioprostil between 0.004 and 10 mg/kg. Rioprostil is eliminated from plasma following an intravenous dose rapidly (t1/2 = 0.22 h) and nearly exclusively by biotransformation. The high total clearance (CL = 5.4 l.h-1.kg-1) indicates an additional extrahepatic metabolism. A systemic bioavailability of 2%, in spite of a rapid and nearly complete absorption (fa = 90%), indicates an extended first-pass effect. Twenty-four hours after the administration of [3H]rioprostil the residual radioactivity in the animal amounted to less than 1% of the dose administered.
Petersen-von Gehr
J K
JK
Bayer AG, Institut für Pharmakokinetik, Wuppertal, FRG.
Siefert
H M
HM
Steinke
W
W
D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D016630:Rioprostil
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil