[Etiopathogenesis of membranous nephropathy: is there a correlation between experimental and human pathology?].
The Authors discuss the etiologic, pathogenetic and immunopathologic aspects of Heymann nephritis, in order to compare the numerous acquisitions concerning this nephropathy with the scanty knowledge of human membranous nephropathy, of which it represents the experimental counterpart. This rat disease can be obtained by inoculation of tubular brush border preparations (active form) or of the relevant antibodies (passive form); after an initial hypothesis of glomerular deposition of circulating immune complexes, studies on its pathogenetic mechanisms, instead demonstrated that in situ immunoaggregates, caused by an interaction between circulating antibodies and fixed glomerular antigens, are formed. Recent investigations have led to the identification of a major nephritogenic antigen (gp330), which is a tubular brush border glycoprotein expressed by coated pits located at the glomerular epithelial cell surface. Studies on antigen-antibody interactions at this level have demonstrated that there is a quick redistribution and accumulation of the so-formed immune complexes, and when polyclonal antibodies were utilized, growth of subepithelial electron dense deposits was observed. Although other tubulo-glomerular antigens, which can also be expressed by endothelial cells, play an uncertain role, they seem to favour transmembrane passing of anti-gp330 antibodies. Immune complex formation gives rise to the onset of proteinuria through complement system activation, without leukocyte involvement: in particular a MAC and C9 fraction lytic effect was demonstrated on cultured epithelial cells. In conclusion, studies on Heymann nephritis contribute to our understanding of the etiopathogenetic mechanisms regarding human membranous nephropathy, and emphasize a possible role played by tubular antigens and in situ formed immune complexes.
Allegri
L
L
Celendo
M T
MT
Savazzi
G
G
Garini
G
G
Carnevali
M L
ML
D000818:Animals; D003165:Complement System Proteins; D005921:Glomerulonephritis / Q000209:etiology; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000209:etiology* / Q000276:immunology; D006801:Humans; D011507:Proteinuria / Q000209:etiology / Q000276:immunology; D051381:Rats
D003165:Complement System Proteins
Eziopatogenesi della nefropatia membranosa: quale correlazione tra la patologia sperimentale ed umana?