Interferon-gamma as adjuvant therapy for resistant warts.
A patient who for 26 years had common warts, which were resistant to various treatment modalities, was treated with a single intralesional injection of interferon-gamma after dinitrochlorobenzene immunotherapy, because immunologic studies indicated she had failed to respond to prior treatment modalities as a result of a functional impairment of her cellular immune response. Within 1 to 2 days, not only the wart injected with interferon-gamma, but also other warts, became erythematous and swollen, giving a lichen planus-like appearance. Without additional injections of interferon-gamma, all warts disappeared completely, leaving slight pigmentation. Interferon-gamma would be most effective when used with, rather than instead of, other immunotherapy.
Shiohara
T
T
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
Hayakawa
J
J
Nagashima
M
M
D001706:Biopsy; D003131:Combined Modality Therapy; D004137:Dinitrochlorobenzene / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007371:Interferon-gamma / Q000276:immunology / Q000627:therapeutic use*; D008875:Middle Aged; D012874:Skin Diseases, Infectious / Q000473:pathology / Q000628:therapy*; D014860:Warts / Q000473:pathology / Q000628:therapy*
D004137:Dinitrochlorobenzene; D007371:Interferon-gamma