Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation.
A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is selective against Pseudomonas aeruginosa. The various congeners are nucleoside peptides which differ in the terminal amino acid residues. The structures were determined using MS-MS and 2D NMR techniques.
Chen
R H
RH
Anti-infective Research, Abbott Laboratories, Abbott Park, Illinois 60064.
Buko
A M
AM
Whittern
D N
DN
McAlpine
J B
JB
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D036341:Intercellular Signaling Peptides and Proteins; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009842:Oligopeptides / Q000032:analysis* / Q000302:isolation & purification; D010455:Peptides; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000032:analysis / Q000302:isolation & purification; D012988:Soil Microbiology; D012995:Solubility; D013302:Streptomyces / Q000378:metabolism*; D014529:Uridine / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D010455:Peptides; D011741:Pyrimidine Nucleosides; C588300:pacidamycin 4; C059936:pacidamycin 1; C059938:pacidamycin 2; C059939:pacidamycin 3; C059941:pacidamycin 5; D014529:Uridine