Modulation of immunological abnormalities of growth hormone-deficient children by growth hormone treatment.
We studied the immunomodulatory role of growth hormone (GH) treatment in GH-deficient children. GH potentiated natural killer (NK)-cell activity and the PHA and Con-A lymphocytoproliferative response. Two-color fluorescence using monoclonal antibodies (CD4, 2H4, CD8 and CD11) showed a moderate reduction of the helper T cells and NK cells, but no changes of suppressor T cells or cytotoxic T-cells during GH therapy. Cancer and slow viral infection in GH-deficient children have been watched for carefully before and after GH therapy.
Matsuura
M
M
Kikkawa
Y
Y
Kitagawa
T
T
Tanaka
S
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D013006:Growth Hormone / Q000172:deficiency* / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D013006:Growth Hormone