Progesterone feedback in normal and sulpiride-induced hyperprolactinemic postmenopausal women.
The feedback effect of progesterone on pituitary gonadotropin release was investigated in ten normal and ten sulpiride-induced hyperprolactinemic postmenopausal women. Forty micrograms of ethinyl estradiol (E2) was administered orally throughout the study. After E2 pre-treatment, 25 mg of progesterone was administered intramuscularly and serum concentrations of LH and FSH were assayed at 4, 8, 12, 24, and 48 hours after injection. A positive feedback effect of progesterone on gonadotropin release was demonstrated in five normoprolactinemic postmenopausal women and in six sulpiride-induced hyperprolactinemic women. These results suggest that the positive feedback effect of progesterone is maintained in sulpiride-induced hyperprolactinemic postmenopausal women as well as in normoprolactinemic postmenopausal women.
Nakano
R
R
Department of Obstetrics and Gynecology, Wakayama Medical College, Japan.
Nishi
T
T
D000368:Aged; D000369:Aged, 80 and over; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced*; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause; D008875:Middle Aged; D011374:Progesterone / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology; D011863:Radioimmunoassay; D013469:Sulpiride / Q000494:pharmacology*
D004997:Ethinyl Estradiol; D011374:Progesterone; D013469:Sulpiride; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone