A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization.
A new antitumor antibiotic, FR900840, was isolated from a culture broth of Streptomyces strain No. 8727 as a pale yellowish prism and the molecular formula was determined to be C7H11N3O5. The antibiotic exhibited prominent antitumor effects on human tumor cell lines both in vitro and in vivo.
Nishimura
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakada
H
H
Nakajima
H
H
Hori
Y
Y
Ezaki
M
M
Goto
T
T
Okuhara
M
M
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D005285:Fermentation; D006801:Humans; D006885:Hydroxybutyrates / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008854:Microscopy, Electron; D012694:Serine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D013171:Spores, Bacterial / Q000648:ultrastructure; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D013696:Temperature; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D006885:Hydroxybutyrates; C058022:thrazarine; D012694:Serine