Interferon-gamma induces class II antigen expression on cultured rat mesangial smooth muscle cells.
In this study, Ia antigen expression was detected on cultured rat mesangial smooth muscle (MSM) cells by anti-Ia monoclonal antibodies and indirect immunofluorescence when the cultures were stimulated with recombinant interferon-gamma. This finding may be relevant to the increased expression of Ia on mesangial cells during immunologically mediated glomerulonephritis, since it is possible that Ia expression may be induced not only on mesangial macrophages but also in MSM cells during immunologic pathogenesis of glomerular injury.
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Renal Service and Laboratory, Hospital Universitario, Maracaibo, Venezuela.
D000818:Animals; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins
D000949:Histocompatibility Antigens Class II; D011994:Recombinant Proteins; D007371:Interferon-gamma