Lack of interaction of HLA and IgG heavy chain allotypes in insulin-dependent diabetes mellitus.
Because of conflicting previous reports showing the presence or absence of Gm-HLA interaction in insulin-dependent diabetes mellitus (IDDM), we report results for a group of Wisconsin families having 2 or more siblings with IDDM. Although this study is very similar to one by Field et al., who found HLA-Gm interaction in IDDM, we find no evidence for such an interactive effect p = 0.33). We discuss published data on HLA-Gm interaction in IDDM, and conclude that overall there is little reason to postulate such an interaction.
Sheehy
M J
MJ
American Red Cross Blood Services, Madison, Wisc.
Meske
L M
LM
Embling
M
M
Berkaw
M
M
Rowe
J R
JR
Pandey
J P
JP
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D008297:Male
D006680:HLA Antigens; D007129:Immunoglobulin Gm Allotypes