title: Physical linkage of variable, diversity and joining gene segments in the immunoglobulin heavy chain locus of the mouse.
abstract: The variable region of antibody heavy chains is encoded by multiple variable (V), diversity (D) and joining (J) gene segments which seem to be assembled in a programmed developmental pathway during the maturation of B lymphocytes. A physical map linking V, D and J gene segments in the a haplotype of the murine Igh locus is presented in this report. The V gene located next to the known D and J gene segments maps 80 kb upstream of the JH locus and is a member of the VGAM3.8 V gene family. There is evidence for as yet unknown D gene segments located 5' to this V gene.
authors.affiliation: Institute for Genetics, University of Cologne, FRG.
authors.forename: T
authors.initials: T
authors.lastname: Christoph
authors.forename: U
authors.initials: U
authors.lastname: Krawinkel
mesh_terms: D000818:Animals; D005803:Genes, Immunoglobulin; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D051379:Mice; D015183:Restriction Mapping
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region