title: Schistosoma bovis as an immunological analogue of S. haematobium.
abstract: The host-parasite relationships of Schistosoma bovis and S. haematobium have been compared in normal and T-cell-deprived mice, and have been found to contrast with that of S. mansoni. Deprived mice infected with either of the former two schistosome species survived as long as, or longer than, comparably infected immunologically intact controls, and hepatocytes of infected deprived mice were not damaged in the absence of granuloma formation. S. mansoni-infected deprived mice, however, die earlier than intact controls, and suffer extensive hepatocellular abnormalities. A high degree of cross-reactivity between S. bovis, S. haematobium and S. mansoni antibodies and antigens was noted in immunoprecipitation but a greater degree of homology between S. haematobium and S. bovis egg antigens was demonstrated by enzyme immunoassay (ELISA). S. haematobium and S. bovis thus resemble each other more closely than either resembles S. mansoni, and in view of the apparent antigenic similarities between S. haematobium and S. bovis and the relatively greater ease with which the S. bovis life-cycle can be maintained in the laboratory, the animal parasite may be useful in providing material for further immunological studies of the human infection.
authors.affiliation: Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Agnew
authors.forename: H M
authors.initials: HM
authors.lastname: Murare
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
authors.forename: M J
authors.initials: MJ
authors.lastname: Doenhoff
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D001219:Aspartate Aminotransferases / Q000097:blood; D003429:Cross Reactions; D007108:Immune Tolerance; D008099:Liver / Q000276:immunology / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D012547:Schistosoma / Q000276:immunology*; D012548:Schistosoma haematobium / Q000276:immunology*; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D012553:Schistosomiasis haematobia / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D001219:Aspartate Aminotransferases