[Effect of testosterone preparations on the function of the hypothalamic pituitary axis in Klinefelter's syndrome].
This article prospectively observed the suppressive effects of the testosterone preparations on the elevated gonadotropin levels in Klinefelter's syndrome (KS). After sublingual administration of methyl testosterone 5 mg Bid, the serum T levels increased 97 and 126 ng/ml respectively in 6 normal men and 9 patients of KS and the serum FSH and LH levels did not changed significantly. After intramuscular injection of testosterone propionate 25 mg 3/week testovirone 100 mg 1/10 days and testosterone enanthate 200 mg/20 days, the serum T levels increased significantly both in 6 normal mon and 17 patients with KS. It took about 1 month for the LH levels to decrease to normal range and 3-6 months for the FSH levels to become normal. Our result indicates that it is necessary to treat the KS patients for long period to normalize the increased hypothalamic pituitary function.
Shi
Y F
YF
Xiang
H D
HD
Wu
Q Y
QY
D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D007713:Klinefelter Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone