title: APB selectively reduces visual responses in goldfish to high spatiotemporal frequencies.
abstract: Visual responses of goldfish to rotating square-wave gratings were recorded before and after intraocular injection of 2-amino-4-phosphonobutyric acid (APB). High doses of APB reduced the rate of optokinetic nystagmus (OKN) to a relatively high spatial frequency grating moving at a high temporal frequency. Responses to a low spatial frequency grating were not altered, nor were responses to the higher spatial frequency when it rotated slowly. The effects of APB were transient and lasted no longer than 3 d. We conclude that APB reduces OKN to high spatiotemporal frequencies in goldfish.
authors.affiliation: Department of Psychology, Vanderbilt University, Nashville, TN 37240.
authors.forename: P J
authors.initials: PJ
authors.lastname: DeMarco
authors.forename: J D
authors.initials: JD
authors.lastname: Nussdorf
authors.forename: D A
authors.initials: DA
authors.lastname: Brockman
authors.forename: M K
authors.initials: MK
authors.lastname: Powers
mesh_terms: D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D004596:Electroretinography; D009760:Nystagmus, Physiologic / Q000187:drug effects; D010775:Photic Stimulation / Q000379:methods*; D012399:Rotation; D013028:Space Perception / Q000502:physiology; D013997:Time Factors; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D000613:Aminobutyrates; C012729:2-amino-4-phosphonobutyric acid