Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat.
It has been suggested that a nonapeptide called V-9-M (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) is produced by the processing of procholecystokinin. However, its physiological and pharmacological activities are not known. In the present study, synthetic V-9-M amide was injected into the lateral ventricle of the rat and its effects on general activities were observed. V-9-M caused a marked sedation; it suppressed spontaneous activity and hypermotility induced by thyrotropin-releasing hormone, methamphetamine, and apomorphine. Hypomotility induced by small doses of apomorphine was also decreased further. V-9-M caused hypothermia and prolonged the duration of pentobarbital-induced sleep, and it decreased locomotion in an open-field situation. However, V-9-M did not affect appetite in fasted rats.
Takashima
A
A
Shionogi Research Laboratories, Osaka, Japan.
Itoh
S
S
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D010446:Peptide Fragments; D011498:Protein Precursors; D008694:Methamphetamine; D013973:Thyrotropin-Releasing Hormone; C060249:procholecystokinin; D002766:Cholecystokinin; C060250:V-9-M cholecystokinin nonapeptide; D010424:Pentobarbital; D001058:Apomorphine