[The oxygen transport function and energy metabolism of erythrocytes in human aging].
Age-related changes of hemoglobin affinity to oxygen and intraerythrocyte factors which determine it (pH, pCO2, rate of glycolysis, content of organic phosphates) were studied. The results obtained showed the decrease in aging of the affinity of hemoglobin to oxygen resultant from the decrease of pH of intraerythrocyte medium (Bohr effect), despite the inhibited energy metabolism and decreased content of organic phosphates in erythrocytes.
Korkusko
O V
OV
Institut für Gerontologie, Akademie der Medizinischen Wissenschaften der UdSSR, Kiev.
Ivanov
L A
LA
Pisaruk
A V
AV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002245:Carbon Dioxide / Q000097:blood; D004734:Energy Metabolism; D004912:Erythrocytes / Q000502:physiology*; D006019:Glycolysis; D006452:Hemoglobinometry; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000502:physiology; D010710:Phosphates / Q000097:blood
D010108:Oxyhemoglobins; D010710:Phosphates; D002245:Carbon Dioxide; D010100:Oxygen
Sauerstofftransportfunktion und Energieumsatz von Erythrozyten beim Altern des Menschen.