Evolutionary expression of the neuronal form of the src protein in the brain.
The protooncogene src encodes two proteins, designated pp60c-src+ and pp60c-src.pp60c-src+ is expressed only in neurons, whereas pp60c-src is expressed in neuronal and nonneuronal cells. pp60c-src+ differs from pp60c-src in that it contains an insert of 6 amino acids. To study the evolutionary conservation of the 6-amino acid insert, the expression of pp60c-src+ in the brain of animals from different classes was assayed by using pp60c-src+-specific antibodies raised against a synthetic peptide corresponding to the insert. pp60c-src+ was detected only in the brain of mammals, birds, and reptiles, but not amphibians and fish, whereas pp60c-src was present in the brain of all animals tested, including lobster (invertebrate). These findings indicate that pp60c-src+ may play a role in events associated with higher brain function, such as neuronal plasticity.
Yang
X M
XM
Department of Pathology, La Jolla, CA 92093.
Martinez
R
R
Le Beau
J
J
Wiestler
O
O
Walter
G
G
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000201:enzymology*; D002460:Cell Line; D006801:Humans; D008969:Molecular Sequence Data; D009447:Neuroblastoma; D009474:Neurons / Q000201:enzymology*; D015688:Oncogene Protein pp60(v-src); D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011519:Proto-Oncogenes; D012191:Retroviridae Proteins / Q000235:genetics*; D013045:Species Specificity
D012191:Retroviridae Proteins; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)