Effects of dopamine receptor antagonists on sucrose consumption and preference.
Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentrations, but had no effect at high concentrations; reducing drive level had exactly the opposite pattern of effects. In two-bottle tests, both drugs reduced preference for the weakest sucrose concentration (0.7%) but increased preference for the strongest concentration (34%). The effects of antagonizing either subtype of DA receptor appear to be similar to those of reducing the concentration of sucrose.
Muscat
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R
Psychology Department, City of London Polytechnic, UK.
Willner
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P
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004326:Drinking / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013395:Sucrose / Q000008:administration & dosage*; D013469:Sulpiride / Q000494:pharmacology*
D001552:Benzazepines; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D013395:Sucrose; D013469:Sulpiride