Single-electron-transfer in the reduction of 1,2-dioxetanes by biologically active substrates.
Substances of low oxidation potential, which can also make available protons and hydrogen atoms, e.g. phenothiazines, NADH, and ascorbic acid efficiently reduce 1,2-dioxetanes to their vic-diols by single-electron-transfer; a significant side reaction is catalytic decomposition of dioxetanes into the corresponding ketone fragments.
Adam
W
W
Institute of Organic Chemistry, University of Würzburg, F.R.G.
Vargas
F
F
Epe
B
B
Schiffmann
D
D
Wild
D
D
D001205:Ascorbic Acid; D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine; D004579:Electron Transport; D006571:Heterocyclic Compounds; D009243:NAD; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D006571:Heterocyclic Compounds; D009243:NAD; D001205:Ascorbic Acid; D002746:Chlorpromazine