title: [Acute and subchronic effect of a patch with discontinuous nitroglycerin liberation].
abstract: We investigated a new patch with 15 mg nitroglycerine and a drug release of 70% during the first 12 h of application, designed to prevent tolerance. In a double blind placebo controlled trial 12 patients with angiographically significant coronary artery disease, angina and reproducible ST-segment depression during exercise were studied. Stress-tests with a constant workload were performed before, 1 h, 4 h and 8 h after first day application as well as after 8-10 days of therapy. At the first day the sum of ST-segment depression (lead V 5) during each minute of exercise and the 5 minutes of recovery decreased by 55.5% (1 h, p less than 0.001), 47.4% (4 h, p less than 0.001) and 28.4% (8 h, n.s.). After subchronical application the relative values were 32% (1 h, p less than 0.05), 23.8% (4 h, n.s.) and no change after 8 h. Thus the new patch is effective between 1 h and 8 h of acute application. With chronic therapy however tolerance occurs despite the fact that only a small amount of nitroglycerine is released during the last half of a 24 h application.
authors.affiliation: Rotes Kreuz Krankenhaus, Abt. Kardiologie, Frankfurt.
authors.forename: C
authors.initials: C
authors.lastname: Schirnick
authors.forename: N
authors.initials: N
authors.lastname: Reifart
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016032:Randomized Controlled Trials as Topic
chemical_list: D005996:Nitroglycerin
vernacular_title: Akute und subchronische Wirkung eines Pflasters mit diskontinuierlicher Nitroglycerinfreisetzung.