[The intraperitoneal installation of gamma interferon for the treatment of refractory ovarian carcinoma].
Patients with refractory ovarian cancer were treated intra-peritoneally with interferon-gamma. The maximum tolerated dose was achieved at 2 mg/m2. The substance was administered 3 times per week every second week. Interferon-gamma treatment activated locally the macrophages and induced a rise in neopterin urine, serum, and ascites levels. The tumor marker CA-125 showed marked fluctuations of more than 100% during interferon treatment and this was not correlated with neopterin. A flu-like syndrome and especially fatigue were the dose limiting side effects. Two of 3 evaluable patients died on tumor progression whereas one is now 18 months clinically free of disease.
Marth
C
C
Universitätsklinik für Frauenheilkunde Innsbruck.
Mull
R
R
Gastl
G
G
Herold
M
M
Steiner
E
E
Daxenbichler
G
G
Hetzel
H
H
Flener
R
R
Huber
C
C
Dapunt
O
O
D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001708:Biopterins / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis; D003536:Cystadenocarcinoma / Q000628:therapy*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D019798:Neopterin; D010051:Ovarian Neoplasms / Q000628:therapy*
D015295:Antigens, Tumor-Associated, Carbohydrate; D001708:Biopterins; D019798:Neopterin; D007371:Interferon-gamma
Die intraperitoneale Instillation von Interferon-gamma zur Behandlung des refraktären Ovarialkarzinoms.