title: [Detoxification with orthograde intestinal lavage in oral poisoning by tetrachloromethane (CCl4) in an animal experiment].
abstract: A detoxication treatment with whole-gut irrigation was used in 231 rats after intragastral application of tetrachloromethane. Different irrigation methods were compared by means of survival time, liver enzyme activities and time until the beginning of diarrhoe. In comparison to the untreated animals significantly longer survival time could be found with whole-gut irrigation. By initial application of carbo medicinalis the liver enzyme activity rise in serum was at its lowest level and the diarrhoe could begin faster than in additional laxans (paraffin, Bisacodyl and sodium sulfate) use. A poison removal with whole-gut irrigation and carbo medicinalis use is also to be proposed when tetrachloromethane is ingested by human beings.
authors.affiliation: Medizinisch-Poliklinischen Institut, Bereichs Medizin der Karl-Marx-Universität Leipzig, DDR.
authors.forename: J
authors.initials: J
authors.lastname: Otto
authors.forename: V
authors.initials: V
authors.lastname: Görisch
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000628:therapy*; D005260:Female; D005751:Gastric Lavage / Q000379:methods; D007422:Intestines; D008111:Liver Function Tests; D008353:Mannitol / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D008353:Mannitol; D000410:Alanine Transaminase
vernacular_title: Zur Giftentfernung mit orthograder Darmspülung bei oraler Intoxikation durch Tetrachlormethan (CCI4) im Tierversuch.