Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment.
Rats with more severe orofacial movements after 51 days of haloperidol administration showed lower levels of the dopamine metabolite homovanillic acid (HVA) in the caudate compared to animals who did not develop significant mouth movements. This effect was not observed in other brain regions sampled. This finding is consistent with the hypothesis that dopaminergic receptor supersensitivity in neostriatal structures plays some role in the development of orofacial movements in rats, in association with chronic neuroleptic administration.
Kolenik
S A
SA
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519.
Hoffman
F J
FJ
Bowers
M B
MB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism*; D008297:Male; D009055:Mouth; D051381:Rats; D011919:Rats, Inbred Strains
D006220:Haloperidol; D006719:Homovanillic Acid