Increased expression of HLA-DR antigen on alveolar macrophages in pulmonary diseases.
The expression of HLA-DR antigen on alveolar macrophages obtained by bronchoalveolar lavage in healthy controls and patients with different diseases was investigated, using cytofluorographic analysis and phykoerythrin conjugated monoclonal mouse anti-human HLA-DR antibody. Alveolar macrophages in patients with extrinsic allergic alveolitis (n = 4), idiopathic lung fibrosis (n = 4), sarcoidosis (n = 6), rheumatoid lung disease (n = 6) and pulmonary infection (n = 5) showed increased density of HLA-DR antigen expression compared to healthy control subjects (n = 5). The increased expression of HLA-DR antigen on alveolar macrophages confirms the importance of these cells for recognition of antigens and immunological responses in different pulmonary diseases.
Popp
W
W
Pulmonary Department, KH Lainz, Vienna, Austria.
Braun
O
O
Zwick
H
H
Rauscher
H
H
Ritschka
L
L
D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D002452:Cell Count; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000276:immunology* / Q000473:pathology
D006684:HLA-DR Antigens