Mechanism of antigenic variation in Shigella flexneri bacilli. I. Selective lethal effect of normal sera on mixed population of S. flexneri 1b serotype and its antigenic 3b mutant.
Normal non-immune calf, human and mice sera kill-preferentially the Shigella flexneri 1b serotype cells with antigenic formula I; 3, 4, 6 leaving the antigenic mutant cells of the serotype 3b with antigenic formula III; 3, 4, 6. The strongest lethal action was observed in normal calf serum. This serum makes possible to obtain the 3b serotypes mutant from pure population of 1b serotype cells. Thermal inactivation of the complement deprives the serum of its selective activity.
Doroszkiewicz
W
W
Institute of Microbiology, Wrocław University.
Lachowicz
T M
TM
D000818:Animals; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000235:genetics; D001770:Blood Bactericidal Activity / Q000276:immunology*; D002417:Cattle; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009154:Mutation; D012703:Serotyping; D012763:Shigella flexneri / Q000145:classification / Q000235:genetics / Q000276:immunology*
D000942:Antigens, Bacterial; D003165:Complement System Proteins