title: Which routine test for kidney function?
abstract: Eighty measurements of plasma creatinine concentration, height:creatinine ratio, and plasma beta 2 microglobulin concentration were made on 72 children (age 4 months-18.5 years) with known renal disease. Results were compared with simultaneous measurements of glomerular filtration rate using plasma clearance of 51Cr edetic acid to assess the performance of each test as an initial screening procedure of renal insufficiency. Height:creatinine index less than 2.1 was found to have a higher sensitivity and predictive value of a normal result than the other tests and is therefore the preferred test for a screening procedure.
authors.affiliation: Department of Medical Physics, St James's University Hospital, Leeds.
authors.forename: A
authors.initials: A
authors.lastname: Parkin
authors.forename: H C
authors.initials: HC
authors.lastname: Smith
authors.forename: J T
authors.initials: JT
authors.lastname: Brocklebank
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin; D004492:Edetic Acid; D003404:Creatinine