title: Rapid resolution of acute cor pulmonale with recombinant tissue plasminogen activator.
abstract: A case of massive pulmonary embolism complicated by acute cor pulmonale and shock is presented. The IV administration of recombinant tissue-type plasminogen activator (rt-PA) was associated with prompt reversal of clinical, ECG, and nuclear radiographic findings. The role of thrombolytic therapy with rt-PA for massive pulmonary embolism associated with hemodynamic decompensation deserves further investigation.
authors.affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester.
authors.forename: J M
authors.initials: JM
authors.lastname: Gore
authors.forename: M J
authors.initials: MJ
authors.lastname: Thompson
authors.forename: R C
authors.initials: RC
authors.lastname: Becker
mesh_terms: D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator