title: Effect of melatonin on jet lag after long haul flights.
abstract: OBJECTIVE
  To determine whether doses of the pineal hormone melatonin alleviate jet lag.
  
  
  METHODS
  Double blind, placebo controlled crossover trial.
  
  
  METHODS
  Long haul return flights from Auckland, New Zealand, to London and back.
  
  
  METHODS
  Twenty volunteers with experience of transcontinental flights (eight women and 12 men aged 28 to 68).
  
  
  METHODS
  Melatonin (or placebo) 5 mg three days before flight, during flight, and once a day for three days after arrival.
  
  
  METHODS
  Symptoms of jet lag.
  
  
  RESULTS
  Visual analogue scale for feelings of jet lag and tiredness; profile of moods states questionnaire for vigour-activity and fatigue-inertia; and retrospective ratings 10 days after arrival of sleep pattern, energy, and daytime tiredness. Feelings of jet lag were less for subjects taking melatonin (mean score 2.15 v 3.4); these subjects took fewer days than the placebo group to establish a normal sleep pattern (2.85 v 4.15), to not feel tired during the day (3.0 v 4.6), and to reach normal energy levels (3.25 v 4.7). Results for fatigue-inertia and vigour-activity were similar. For all subjects jet lag was more severe on the return (westward) than the outward (eastward) journey.
  
  
  CONCLUSIONS
  Melatonin can alleviate jet lag and tiredness after long haul flights.
authors.affiliation: Department of Psychology, Waikato Hospital, Hamilton, New Zealand.
authors.forename: K
authors.initials: K
authors.lastname: Petrie
authors.forename: J V
authors.initials: JV
authors.lastname: Conaglen
authors.forename: L
authors.initials: L
authors.lastname: Thompson
authors.forename: K
authors.initials: K
authors.lastname: Chamberlain
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005221:Fatigue / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors; D014195:Travel
chemical_list: D008550:Melatonin