The detection of an antibody against IgA allotype A2M 2 and a study of the Am genetic marker among the Han Chinese population.
The serum of a woman was found by the Ouchterlony double-diffusion and the hemagglutination inhibition (HAI) methods to have immunoglobulin A (IgA) deficiency. Further investigation using the hemagglutination (HA) test with red cells coated with IgA myeloma proteins of different specificities showed that the serum agglutinated only IgA2-, A2M-1, and A2M 2-coated cells. The patterns of the HAI test with a reference panel confirmed the presence of two specificities. One was anti-IgA2 and the other was a rare antibody against the allotype A2M 2. The anti-A2M 2 was used for population studies. Testing of the Han Chinese population, including family studies, confirms that A2M.1 and A2M.2 have an autosomal dominant mode of inheritance and are controlled by a codominant allele. The distribution of the two Am genetic markers among the Han Chinese population demonstrated A2M.1 with a gene frequency of 0.553 and A2M.2 with a gene frequency of 0.447 (chi 2 = 0.145, 0.80 greater than p greater than 0.70).
Wu
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Blood Group Reference Laboratory of Shanghai Red Cross Blood Center, People's Republic of China.
Liu
D
D
Fang
G
G
Hu
W
W
Jia
H
H
Zhang
Q
Q
Fukada
K
K
Yoshimura
K
K
Saji
H
H
Lee
T D
TD
D000483:Alleles; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000918:Antibody Specificity; D002681:China; D005190:Family; D005819:Genetic Markers; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D005819:Genetic Markers; D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; C049937:anti-IgA