title: Ultrastructural localization of thyrotropin-releasing hormone immunoreactivity in the dorsal vagal complex in rat.
abstract: Thyrotropin-releasing hormone-like immunoreactivity (TRH-LI) was localized at the ultrastructural level in the dorsal vagal complex (DVC: dorsal motor nucleus of the vagus (DMV) and the nucleus of the solitary tract (NST] in rat. TRH-LI was concentrated in large granular vesicles in axons, presynaptic terminals, and non-synaptic axon varicosities. TRH-LI presynaptic terminals established both asymmetric and symmetric synaptic contacts with dendrites. These observations are consistent with recently described direct inhibitory and facilitatory effects of TRH on the electrical activity of neurons in the DVC.
authors.affiliation: Institute of Neurological Sciences, University of Pennsylvania, Philadelphia 19104.
authors.forename: L
authors.initials: L
authors.lastname: Rinaman
authors.forename: R R
authors.initials: RR
authors.lastname: Miselis
authors.forename: M S
authors.initials: MS
authors.lastname: Kreider
mesh_terms: D000818:Animals; D001369:Axons / Q000032:analysis; D003712:Dendrites / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000032:analysis / Q000648:ultrastructure; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000032:analysis / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000032:analysis; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*; D014630:Vagus Nerve / Q000648:ultrastructure*
chemical_list: D013973:Thyrotropin-Releasing Hormone