Ponalrestat: a potent and selective inhibitor of bovine lens aldose reductase.
Tuffin
D P
DP
ICI Pharmaceuticals Division, Macclesfield, Cheshire, U.K.
Dingle
A
A
Sennitt
C M
CM
Mirrlees
D J
DJ
Ward
W H
WH
D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007700:Kinetics; D007908:Lens, Crystalline / Q000201:enzymology*; D008433:Mathematics; D015394:Molecular Structure; D010793:Phthalazines; D013379:Substrate Specificity; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D007004:Hypoglycemic Agents; D010793:Phthalazines; C042829:ponalrestat; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; D000445:Aldehyde Oxidoreductases