Synthesis and characterization of new chromium(III), vanadium(IV), and titanium(III) complexes with biologically active isonicotinic acid hydrazide.
New complexes of the type [Cr(INH)2Cl2]Cl.2H2O, VO(INH)2Cl2 and TiO(INH)2Cl, where INH = isonicotinic acid hydrazide, have been prepared. The complexes were characterized by infrared and UV-vis spectroscopy, proton nuclear magnetic resonance (NMR) and elemental analyses, molar conductivity and x-ray powder diffraction measurements. For the Cr(III)-complex, the ligand was coordinated through its carbonyl group and amino nitrogen atom; for V(IV)-complex and Ti(III)-complex, the ligand was coordinated through its carbonyl oxygen and heterocyclic nitrogen, respectively. Octahedral geometry has been proposed for all the complexes. The complexes of Cr(III) and Ti(III) showed significant tuberculostatic activity.
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Institute of Molecular Science, Shanxi University, Taiyuan, China.
Zhang
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D000995:Antitubercular Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002857:Chromium / Q000032:analysis* / Q000494:pharmacology; D003460:Crystallization; D007538:Isoniazid / Q000032:analysis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014025:Titanium / Q000032:analysis* / Q000494:pharmacology; D014639:Vanadium / Q000032:analysis* / Q000494:pharmacology; D014961:X-Ray Diffraction
D000995:Antitubercular Agents; D014639:Vanadium; D002857:Chromium; D014025:Titanium; D007538:Isoniazid