title: IgM gammopathy and polyneuropathy react with an antigenic glycolipid present in human central nervous system.
abstract: An immunological mechanism may be responsible for the peripheral neuropathies associated with the IgM monoclonal gammopathies. Myelin-associated glycoprotein, and sulfated glucuronic acid-glycosphingolipids of the paragloboside type specific of peripheral nervous system (PNS), have been found to be targets for these antibodies. We report here on the presence of a glycolipid antigen present in central nervous system white matter in 7 of 12 patients with IgM monoclonal gammopathy and neuropathy whose IgM reacts also with the specific sulfated glycolipids of PNS. Immunodetection of the antibodies was performed on thin-layer plates after separation of the glycosphingolipids from peripheral nerve and white matter. The lipid antigen had a migration on thin-layer chromatography close to sulfogalactosylceramide but the sulfatide standard did not react with the monoclonal IgM.
authors.affiliation: Services de Biochimie et de Neurologie, CHU Dupuytren CJF INSERM 8803, Limoges, France.
authors.forename: M O
authors.initials: MO
authors.lastname: Jauberteau
authors.forename: B
authors.initials: B
authors.lastname: Younes-Chennoufi
authors.forename: M
authors.initials: M
authors.lastname: Rigaud
authors.forename: N
authors.initials: N
authors.lastname: Baumann
mesh_terms: D000954:Antigens, Surface / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000097:blood* / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D006017:Glycolipids; D007148:Immunoglobulin mu-Chains