[Effect of (+) cyanidanol-3 on experimental liver cirrhosis induced by carbon tetrachloride].
Liver cirrhosis is a very common illnesses and currently its treatment remains unpromising. In a research line devoted to studying the hepatotoxicity of certain substances we have evaluated the lesions that appear prior to the occurrence of cirrhosis and hepatocarcinoma in order to test, in different assays liver-protecting substances such as cyanidanol-3 that have been seen to lead to an improvement in morphological alterations in the liver and even to reverse such lesions. The mechanisms of action of this compound are discussed. The authors believe that considerable work remains to be carried out but that some day some liver-protecting substances that yield good experimental results may be applied to clinical situations.
Muñoz Torres
E
E
Abad Hernández
M M
MM
López Bravo
A
A
Alonso Martín
M J
MJ
Paz Bouza
J I
JI
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002392:Catechin / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008115:Liver Regeneration / Q000187:drug effects*; D008247:Lysosomes / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D016166:Free Radical Scavengers; D002392:Catechin; D002251:Carbon Tetrachloride
Efecto del (+) cianidanol-3 sobre la cirrosis hepática experimental inducida por el tetracloruro de carbono.