Single-dose tetracycline labeling for bone histomorphometry.
A single oral dose of tetracycline deposits in bone and is readily identified with fluorescence microscopy. Two such time-spaced labels can be used to determine bone dynamic features. This is as accurate as conventional three-day labeling periods. The simplicity, improved compliance, and substantial reduction in time it takes to prepare a patient for bone biopsy all appear to be advantageous when compared with current recommendations.
Sherrard
D J
DJ
University of Washington, Seattle.
Maloney
N A
NA
D000328:Adult; D001851:Bone Diseases, Metabolic / Q000473:pathology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000473:pathology*; D003707:Demeclocycline / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006132:Growth Plate / Q000473:pathology; D006801:Humans; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D013752:Tetracycline / Q000008:administration & dosage
D003707:Demeclocycline; D013752:Tetracycline