title: Drug analysis by near-infra-red reflectance spectroscopy. Determination of the active ingredient and water content in antibiotic powders.
abstract: Near-infra-red reflectance spectroscopy is used to determine the active ingredient concentration and water content of an antibiotic powder (ceftazidime pentahydrate). The validity of predictive models for active ingredient concentrations and water content, constructed by means of the multiple linear regression technique is discussed. A procedure is devised for the analysis of production samples, which, on account of the very limited range of concentrations, prove a difficult fit to the above-mentioned model. The results obtained in testing formulation samples from 1 year's industrial production are used to illustrate the potential of the technique.
authors.affiliation: Direzione Controllo Qualità, Settore Analisi Chimiche, Glaxo S.p.A. Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Lonardi
authors.forename: R
authors.initials: R
authors.lastname: Viviani
authors.forename: L
authors.initials: L
authors.lastname: Mosconi
authors.forename: M
authors.initials: M
authors.lastname: Bernuzzi
authors.forename: P
authors.initials: P
authors.lastname: Corti
authors.forename: E
authors.initials: E
authors.lastname: Dreassi
authors.forename: C
authors.initials: C
authors.lastname: Murratzu
authors.forename: G
authors.initials: G
authors.lastname: Corbini
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D002442:Ceftazidime / Q000032:analysis; D011208:Powders; D013055:Spectrophotometry, Infrared; D014867:Water / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D011208:Powders; D014867:Water; D002442:Ceftazidime