3-(2-Imidazo[4,5-b]pyridine)propionic acid and some of its derivatives with suspected tuberculostatic activity.
The reactions of corresponding 2,3-diamino-pyridines with succinic anhydride were carried out. 3-(2-Imidazo[4,5-b]pyridine)propionic acid and its N-1 and N-3 methyl derivatives were isolated. The acids obtained were converted into the esters, amides, nitriles, thioamides, amidoximes and hydrazides. Some of the synthesized compounds were tested for tuberculostatic activity.
Bukowski
L
L
Department of Organic Chemistry, Medical Academy, Gdańsk, Poland.
Janowiec
M
M
D000995:Antitubercular Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D007093:Imidazoles; D011422:Propionates; C060786:3-(2-imidazo(4,5-b)pyridine)propionic acid