A possible new class of octopamine receptors coupled to adenylate cyclase in the brain of the dipterous Ceratitis capitata. Pharmacological characterization and regulation of 3H-octopamine binding.
Octopamine exerts its effects in insects through interaction with at least two classes of receptors, designated octopamine-1 and octopamine-2. Octopamine-2 receptors are positively coupled to adenylate cyclase, while octopamine-1 receptors are not coupled to this enzyme system. Ceratitis capitata brain appears to have octopamine receptors as unique aminergic receptors coupled to adenylate cyclase. These receptors show some pharmacological analogies with respect to octopamine-2 receptors, however they should constitute a new class of octopamine receptors. C. capitata brain octopamine receptors have also been characterized by [3H]octopamine-binding studies, exhibiting similar regulatory mechanisms to other receptors coupled to adenylate cyclase activation.
Guillén
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Department of Biochemistry, Faculty of Chemistry, Universidad Complutense, Madrid, Spain.
Haro
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Municio
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D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003533:Cyproheptadine / Q000494:pharmacology; D004175:Diptera / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D008787:Metoclopramide / Q000494:pharmacology; D009655:Octopamine / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000032:analysis / Q000378:metabolism*; D017982:Receptors, Biogenic Amine; D015016:Yohimbine / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D011941:Receptors, Adrenergic; D017982:Receptors, Biogenic Amine; C027604:norsynephrine receptor; D009655:Octopamine; D015016:Yohimbine; D003533:Cyproheptadine; C028435:2-octopamine; D000262:Adenylyl Cyclases; D008787:Metoclopramide; D010646:Phentolamine