title: Half-life of alpha-fetoprotein in patients with a teratoma, endodermal sinus tumor, or hepatoblastoma.
abstract: To evaluate the AFP-concentration postoperatively and/or during chemotherapy treatment, a retrospective study was carried out on 14 patients with a teratoma, endodermal sinus tumor (EST), or hepatoblastoma. Eleven patients were operated. Eight of the 11 patients showed postoperatively a linear decline in their AFP concentration. The half-life was about 6 days. In the group of patients that underwent a noncomplete resection, both a linear and a nonlinear declining pattern was seen. The patients that underwent a complete resection showed only a linear decline in the AFP concentration. No relationship was found between the reduction pattern of the AFP and the development of recurrences. The development of a recurrence was accompanied by an increasing AFP concentration.
authors.affiliation: Werkgroep Kindertumoren, Emma Kinderziekenhuis, Netherlands Cancer Institute, Amsterdam.
authors.forename: C M
authors.initials: CM
authors.lastname: Walhof
authors.forename: L
authors.initials: L
authors.lastname: Van Sonderen
authors.forename: P A
authors.initials: PA
authors.lastname: Voûte
authors.forename: J F
authors.initials: JF
authors.lastname: Delemarre
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000097:blood* / Q000628:therapy; D008649:Mesonephroma / Q000097:blood* / Q000628:therapy; D013724:Teratoma / Q000097:blood* / Q000628:therapy; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins