Comparative activity in vitro of 16 antimicrobial agents against penicillin-susceptible meningococci and meningococci with diminished susceptibility to penicillin.
Broad-spectrum cephalosporins were very active against strains of Neisseria meningitidis with both penicillin susceptibility and diminished penicillin susceptibility. Ceftriaxone was the most active antibiotic. Increases in MIC for 90% of meningococci with diminished susceptibility to penicillin of greater than or equal to 16-fold were observed for amdinocillin, cefuroxime, aztreonam, and imipenem; 2-fold increases were observed for ceftazidime, mezlocillin, and piperacillin. No differences were observed for non-beta-lactam antibiotics.
Pérez Trallero
E
E
Servicio de Microbiologia, Hospital NS Aranzazu, Unidad Docente San Sebastian, Spain.
Garcia Arenzana
J M
JM
Ayestaran
I
I
Muñoz Baroja
I
I
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects*; D010403:Penicillin Resistance
D000900:Anti-Bacterial Agents