title: The effect of testosterone replacement on plasma lipids and apolipoproteins.
abstract: Ten men with Klinefelter's syndrome were studied to assess the effect of testosterone replacement on plasma lipids and apolipoproteins. Measurements taken before the insertion of a testosterone ester implant were compared with those obtained 1 week and 4 weeks later. Mean plasma testosterone, androstenedione, total cholesterol and calculated LDL-cholesterol increased significantly after 1 and 4 weeks. No significant changes were seen in total plasma concentrations of HDL-cholesterol, HDL-cholesterol subfractions 2 and 3 or in apoplipoproteins A-I, A-II or B. A significant correlation was seen between total cholesterol and plasma oestradiol concentrations (Rs = 0.61; P less than 0.001). A significant negative correlation was seen between the concentrations of total testosterone and total triglyceride (Rs = -0.56; P less than 0.005) but not with the other lipid parameters. Testosterone replacement is associated with slight but potentially adverse changes in plasma cholesterol levels.
authors.affiliation: Department of Medicine, Western General Hospital, Edinburgh, UK.
authors.forename: D B
authors.initials: DB
authors.lastname: Jones
authors.forename: B
authors.initials: B
authors.lastname: Higgins
authors.forename: J S
authors.initials: JS
authors.lastname: Billet
authors.forename: W H
authors.initials: WH
authors.lastname: Price
authors.forename: C R
authors.initials: CR
authors.lastname: Edwards
authors.forename: G H
authors.initials: GH
authors.lastname: Beastall
authors.forename: J
authors.initials: J
authors.lastname: Shepherd
authors.forename: V M
authors.initials: VM
authors.lastname: Sweeting
authors.forename: D B
authors.initials: DB
authors.lastname: Horn
authors.forename: P R
authors.initials: PR
authors.lastname: Wenham
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000209:etiology; D004967:Estrogens / Q000097:blood; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D012307:Risk Factors; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
chemical_list: D001053:Apolipoproteins; D004967:Estrogens; D008055:Lipids; D013739:Testosterone; D002784:Cholesterol