title: Canthaxanthin retinopathy. Anatomic and functional reversibility.
abstract: Canthaxanthin intake is associated with golden yellow crystalline deposits in the retina around the macula and low static luminance threshold. Our study assesses the anatomic and functional reversibility of canthaxanthin retinopathy. The number of retinal deposits was evaluated in nine patients, two to four times over a mean period of 55 months. There was no significant difference after a nine-month follow-up. A statistically significant decrease in the number of retinal deposits was found after an observation period of 26 months. The deposits disappeared slowly, while some remained even seven years after canthaxanthin therapy was discontinued. Threshold static perimetry performed on eight patients with retinopathy and seven controls did not differ significantly between the two groups at the end of the follow-up period. The results demonstrate that canthaxanthin retinopathy is reversible.
authors.affiliation: Department of Ophthalmology, CHUL Research Center, Laval University Medical Center, Quebec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Harnois
authors.forename: J
authors.initials: J
authors.lastname: Samson
authors.forename: M
authors.initials: M
authors.lastname: Malenfant
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
mesh_terms: D000328:Adult; D016644:Canthaxanthin; D002338:Carotenoids / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D003460:Crystallization; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008875:Middle Aged; D012160:Retina / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D012684:Sensory Thresholds
chemical_list: D002338:Carotenoids; D016644:Canthaxanthin