Selenium chemoprevention of liver cancer in animals and possible human applications.
An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People's Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to aflatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by aflatoxin B1 was observed in lympocytes from human with Se-supplements.
Yu
S Y
SY
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Chu
Y J
YJ
Li
W G
WG
D000348:Aflatoxins; D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D002986:Clinical Trials as Topic; D004354:Drug Screening Assays, Antitumor; D004372:Ducks; D002523:Edible Grain / Q000032:analysis; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D009368:Neoplasm Transplantation; D010865:Pilot Projects; D051381:Rats; D012307:Risk Factors; D020887:Selenious Acid; D012643:Selenium / Q000032:analysis / Q000627:therapeutic use*; D012965:Sodium Chloride; D015002:Yeast, Dried / Q000627:therapeutic use
D000348:Aflatoxins; D000970:Antineoplastic Agents; D000975:Antioxidants; D012965:Sodium Chloride; D020887:Selenious Acid; D012643:Selenium