Do leukocytes have a role in the cerebral no-reflow phenomenon?
The possible role of leukocytes in the cerebral microcirculation following ischaemia was assessed in the gerbil. The no-reflow phenomenon seen after 30 minutes of severe bilateral hemispheric ischaemia during hypotensive reperfusion was compared in control animals and in a group made leukopenic by pretreatment with cyclophosphamide. Neither the incidence nor the severity of the no-reflow phenomenon differed between the two groups. The evidence from this study casts doubt on the hypothesis that leukocyte plugging plays a major role in the cerebral microcirculation's response to ischaemia.
Aspey
B S
BS
Department of Neurological Studies, University College, London, UK.
Jessimer
C
C
Pereira
S
S
Harrison
M J
MJ
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D005849:Gerbillinae; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology*; D012212:Rheology