[The action of an enzymatically stable Leu-enkephalin analog on the prostanoid content in the myocardium under stress- and adrenaline-induced damage].
The protective action of enzymatically stable analogue of Leu-enkephalin (D-ala-2-leu5-arg6), injected intraperitoneally, in the course of stress- and epinephrine induced myocardial damage was demonstrated in animal (129 white rats) experiments. Two effect of enkephalin were sufficient for the cardiac protection: enkephalin-stimulated prostacyclin biosynthesis and simultaneous inhibition of thromboxane production.
Lishmanov
Iu B
IuB
Fedotova
T V
TV
Titov
M I
MI
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003220:Conflict, Psychological; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004837:Epinephrine / Q000633:toxicity*; D011464:Epoprostenol / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism; D013931:Thromboxanes / Q000378:metabolism
D011453:Prostaglandins; D013931:Thromboxanes; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D011464:Epoprostenol; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D004837:Epinephrine
Vozdeĭstvie énzimoustoĭchivogo analoga leĭ-énkefalina na soderzhanie prostanoidov v miokarde pri stressornom i adrenalinom povrezhdenii.