Polymorphonuclear leukocyte function in HIV-1-infected chimpanzees.
The chemiluminescent characteristics of enriched populations of neutrophils from control and HIV-infected chimpanzees were assessed. Neutrophils from HIV-infected chimpanzees were suppressed in their ability to generate a normal response to particulate and soluble stimuli when compared to normal and hepatitis non-A, non B-infected controls. Particulate (latex beads) stimulation of neutrophils resulted in an aberrant response when contrasted with controls. Normal control responses were characteristically biphasic while the response from hepatitis NANB HIV-infected chimpanzees was not biphasic. Neutrophils challenged with a soluble (phorbol ester) stimulant also demonstrated a suppressed response. These data suggest that HIV infection has an additive suppressive effect on neutrophil function in chimpanzees previously infected with hepatitis NANB. The suppression of chimpanzee neutrophil function following HIV infection is similar to that seen in other non-primate viral and retroviral infections.
Lafrado
L J
LJ
Department of Virology/Immunology, Primate Research Institute, Holloman Air Force Base, NM 88330.
Quintana
D A
DA
Javadian
M A
MA
Kelliher
J C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D015497:HIV-1; D006526:Hepatitis C / Q000276:immunology; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D002679:Pan troglodytes / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D013755:Tetradecanoylphorbol Acetate