title: Decontaminating efficacy of ciprofloxacin in an animal model.
abstract: A study was performed to assess the suppressive effect of ciprofloxacin on the aerobic gram-negative flora of the gastrointestinal tract in mice in relation to its effect on colonization resistance. Ciprofloxacin exhibited a potent decontaminating effect, with the maximum effect being reached at a dose of 8 mg/kg/day. At this dose aerobic gram-negative rods were eliminated from the gastrointestinal tract within 24h without any adverse influence on the parameters of colonization resistance measured.
authors.affiliation: Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
authors.forename: M L
authors.initials: ML
authors.lastname: van Ogtrop
authors.forename: H
authors.initials: H
authors.lastname: Mattie
authors.forename: H F
authors.initials: HF
authors.lastname: Guiot
authors.forename: R
authors.initials: R
authors.lastname: van Furth
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D002432:Cecum / Q000382:microbiology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D004064:Digestive System / Q000382:microbiology*; D004195:Disease Models, Animal; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D008297:Male; D051379:Mice
chemical_list: D002939:Ciprofloxacin