The oncogene jun and nuclear signalling.
Jun is a transcription factor that can also induce oncogenic transformation. Its DNA-binding domain is conserved from yeast to man and shows homology to several other transcriptional regulators. Jun dimerizes with the fos protein through an alpha-helical domain termed the leucine zipper, and the jun-fos heterodimers bind to DNA and regulate transcription of numerous specific unlinked genes.
Vogt
P K
PK
Bos
T J
TJ
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D016759:Oncogene Protein p65(gag-jun); D012191:Retroviridae Proteins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D016759:Oncogene Protein p65(gag-jun); D012191:Retroviridae Proteins