[Acetylation phenotype and the changes in selected indicators of calcium-phosphate metabolism in patients with hyperthyroidism treated with propranolol].
The occurrence of acetylation phenotype has been studied in 76 patients with untreated hyperthyroidism. In 23 of these patients having the "fast" and in 42 having the "slow" acetylation phenotype the selected parameters of calcium-phosphate metabolism have been determined before, during and after propranolol therapy lasting six days. Propranolol was administered at a dose of 160 milligrams daily. A significant decrease in the blood serum level of calcium and urinary calcium excretion following propranolol administration was found only in patients with hypercalcemia and hypercalciuria. On the other hand, a significant decrease in the urinary excretion of hydroxyproline was observed in all the patients with hyperthyroidism treated with propranolol. The effect of propranolol on the measured parameters of calcium-phosphorus metabolism was similar in hyperthyroid patients with both "fast" and "slow" acetylation phenotypes, what suggests that it does not depend on the N-acetyltransferase activity.
Gasińska
T
T
Wawrzyniak
L
L
Widala
E
E
D000107:Acetylation / Q000187:drug effects; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010710:Phosphates / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use*
D010710:Phosphates; D011433:Propranolol; D000123:Acetyltransferases; D002118:Calcium
Fenotyp acetylacji a zachowanie sie wybranych wskaźników prezemiany wapniowo-fosforanowej u chorych z nadczynnościa tarczycy leczonych propranolem.