Primary treatment of carcinoma of the anus by combined radiotherapy and chemotherapy.
Twenty-four patients with carcinoma of the anus were treated with a combined regimen of external irradiation (50 Gy) and mitomycin C and 5-fluorouracil. A relatively large number of patients with locally advanced disease were included. A local complete response rate of 87.5% was obtained. The major acute toxicity was dermatitis/mucositis, necessitating a split course in 14 cases. After treatment four patients had persistent anal incontinence. After an observation period of 40-70 months 14 of the patients were alive without disease. We conclude that the conservative combined radiotherapy/chemotherapy regimen is an effective treatment also of advanced anal carcinoma, with tolerable toxicity and with promising survival results.
Tveit
K M
KM
Norwegian Radium Hospital, Montebello, Oslo, Norway.
Karlsen
K O
KO
Fosså
S D
SD
Flokkmann
A
A
Guldvog
I
I
Haffner
J
J
D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000628:therapy*; D002277:Carcinoma / Q000175:diagnosis / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use
D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil