Investigation of the relationship between melting-related parameters and in vitro drug release from vaginal suppositories.
The effect of temperature on drug release from meteneprost potassium vaginal suppositories was investigated using a dissolution test based on the USP I apparatus. Comparison of the dissolution results with the DSC melting behaviour revealed that drug release was extremely slow until melting of the suppository was essentially complete. The melting behaviour of the meteneprost potassium suppositories was also varied by preparing suppositories from bases with higher and broader melting ranges. The observed dissolution behaviour (at 37 degrees C) confirmed that drug release increased as the melting temperature of a particular suppository decreased. Differential scanning calorimetry, viscosity and dilatometry methods were used to characterize the suppository melting process. The effects of suppository melting range, melt temperature and composition were investigated with respect to in vitro drug release. Methodology for the HPLC determination of meteneprost in suppositories and in dissolution media are also reported.
Bergren
M S
MS
Control Research Laboratories, Upjohn Company, Kalamazoo, MI 49001.
Battle
M M
MM
Halstead
G W
GW
Theis
D L
DL
D015064:16,16-Dimethylprostaglandin E2 / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000282:Administration, Intravaginal; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D013488:Suppositories; D013816:Thermodynamics; D014783:Viscosity
D013488:Suppositories; C025505:meteneprost; D015064:16,16-Dimethylprostaglandin E2