title: Hypothalamic neurons from a developmental aspect.
abstract: The development of hypothalamic neurons was examined in vivo and in transplanted grafts in rats. The neurons appeared in vivo in distinctive chronotopical schedules showing such morphological characteristics as synaptocrine or hemocrine neurons. These phenotypical properties seemed to be primed already by day 12.5 of gestation in rats, because the grafted hypothalamic primordia from 12.5-day-old embryonal rats differentiated neurons, which express these neuronal properties in the third ventricle of adult female rats. The synaptocrine neurons projected to other neurons, suggesting the establishment of synaptic contacts, and the hemocrine neurons projected to vasculatures developed in the grafts, suggesting the accomplishment of neurovascular associations.
authors.affiliation: Department of Anatomy, Tokushima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Daikoku
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuruo
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Okamura
authors.forename: R
authors.initials: R
authors.lastname: Yokote
authors.forename: M
authors.initials: M
authors.lastname: Ide
mesh_terms: D000818:Animals; D002455:Cell Division; D002552:Cerebral Ventricles / Q000166:cytology; D007031:Hypothalamus / Q000166:cytology* / Q000196:embryology; D009474:Neurons / Q000166:cytology* / Q000201:enzymology / Q000637:transplantation; D051381:Rats; D014182:Transplantation, Autologous