[Spontaneous post-partum inhibitor to factor VIII clotting anti- gen--a cause of life-threatening hemorrhage].
Pathologic inhibitors of blood coagulation as cause of acquired haemostatic failure are rare. We report about a 23 years old primigravida with a life-threatening haemorrhage post partum. Analysis of coagulation parameters showed the presence of inhibitor to factor VIII. We reacted successfully with cyclophosphamid and cryoprecipitated factor VIII. References to diagnostic and therapy of pathologic clotting factor inhibitors are described.
Lutze
G
G
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Medizinischen Akademie Magdeburg.
Canzler
E
E
Presser
H J
HJ
D000328:Adult; D000941:Antigens / Q000172:deficiency* / Q000378:metabolism*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology* / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use; D005353:Fibronectins / Q000627:therapeutic use; D005500:Follow-Up Studies; D006467:Hemophilia A; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014842:von Willebrand Diseases
D000941:Antigens; D005353:Fibronectins; C026912:cryoprecipitate coagulum; D003520:Cyclophosphamide; D005169:Factor VIII; D005340:Fibrinogen
Spontaner Gerinnungsfaktor-VIII: C-Inhibitor post partum--Ursache lebensbedrohlicher Blutung.