title: Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetin.
abstract: Previous studies suggested that acetate in parenteral solutions may adversely affect mineral metabolism by causing sequestration of inorganic phosphate and calcium in the liver. In this study, triacetin, a short-chain triglyceride of acetate and a potential parenteral nutrient, was infused for 3 h at an isocaloric rate in mongrel dogs (n = 6) to test its effects on serum phosphorus, calcium, and magnesium metabolism. There was no change in serum P or Ca. The serum Mg concentration decreased from 0.7 +/- 0.03 to 0.57 +/- 0.03 mmol/L (p less than 0.001) by 90 min and remained at this level for the remainder of the study. The triacetin infusion did not influence fractional urinary Mg excretion; thus, the decrease in serum Mg was likely because of an increase in cellular transport of this cation. A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism.
authors.affiliation: Endocrine Research Unit, Mayo Clinic and Medical School, Rochester, MN 55905.
authors.forename: J W
authors.initials: JW
authors.lastname: Bailey
authors.forename: H
authors.initials: H
authors.lastname: Heath
authors.forename: J M
authors.initials: JM
authors.lastname: Miles
mesh_terms: D000085:Acetates / Q000097:blood; D019342:Acetic Acid; D000818:Animals; D001481:Basal Metabolism; D002118:Calcium / Q000378:metabolism*; D004285:Dogs; D008274:Magnesium / Q000378:metabolism*; D010288:Parenteral Nutrition; D010758:Phosphorus / Q000378:metabolism*; D014215:Triacetin / Q000494:pharmacology*; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D000085:Acetates; D014280:Triglycerides; D010758:Phosphorus; D008274:Magnesium; D019342:Acetic Acid; D002118:Calcium; D014215:Triacetin