title: Evaluation of whole blood filterability with increasing age in healthy men and women.
abstract: Whole blood filterability, expressed as volume of red blood cells filtered per minute (VRBC), was evaluated in 53 healthy men and 56 healthy women; in each sex, subjects were divided into 4 groups according to their age: adult age (20-50 yr.), advanced adult age (51-60 yr); presenile age (61-70 yr.) and senile age (greater than 70 yr.). In addition, plasma fibrinogen, PCV, white cell and platelet total counts were measured and correlated with VRBC. Whole blood filterability and plasma fibrinogen levels were also correlated with age. VRBC and PCV decreased, whereas fibrinogen levels increased with increasing age. VRBC values showed a significant negative correlation with age and plasma fibrinogen values; a significant positive correlation was found between fibrinogen levels and age. No other examined parameter changed with increasing age nor correlated with VRBC values. These findings indicate that with aging there are modifications of some rheological parameters, such as an increase in plasma fibrinogen levels and a decrease in whole blood filterability.
authors.forename: G
authors.initials: G
authors.lastname: Gelmini
authors.forename: V
authors.initials: V
authors.lastname: Coiro
authors.forename: P
authors.initials: P
authors.lastname: Ferretti
authors.forename: M C
authors.initials: MC
authors.lastname: Baroni
authors.forename: R
authors.initials: R
authors.lastname: Delsignore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D001772:Blood Cell Count; D004907:Erythrocyte Deformability; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
chemical_list: D005340:Fibrinogen