title: Effects of extracellular calcium and sodium on cadmium uptake in guinea-pig and rabbit aorta.
abstract: 1. Effects of Na+ and Ca2+ on Cd2+ uptake in the guinea-pig and rabbit aorta were investigated. 2. The Cd2+ fraction can be divided with EDTA and Zn2+. The EDTA fraction may be intracellular fraction and the Zn2+ fraction may be loosely bound to surface membrane. 3. In Na+ deficient solution the Zn2+ fraction was markedly increased and the EDTA fraction also increased while the external Ca2+ concentrations scarcely affect the Cd2+ contents in both fractions. 4. Cd2+ did not affect the cellular Na+ and K+ contents. 5. These results suggest that Na+ strongly relates with these fractions but Na+ pump does not contribute to these phenomena.
authors.affiliation: Department of Veterinary Public Health, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ueda
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Shimazaki
mesh_terms: D000818:Animals; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
chemical_list: D002104:Cadmium; D004492:Edetic Acid; D012964:Sodium; D015032:Zinc; D011188:Potassium; D002118:Calcium