title: Lactic dehydrogenase estimation in haematological malignancies.
abstract: Earlier studies have indicated a role for serum lactic dehydrogenase (LDH) in haematological and other malignancies. As this is still not a routine test in many units, its value has been re-examined in a retrospective analysis of serum LDH levels in 278 patients with haematological malignancies managed in a single unit. Abnormal levels at diagnosis were found in 42% of these disorders; yet analysis of over 23,000 routine requests for a biochemical screen showed only 4% with an abnormal LDH level. The estimation was also valuable in follow-up of those haematological patients, with rising levels often indicating progressive or relapsing disease even in cases which had shown a normal LDH at diagnosis.
authors.affiliation: Department of Haematology, Victoria Hospital, Blackpool, UK.
authors.forename: N G
authors.initials: NG
authors.lastname: Flanagan
authors.forename: J C
authors.initials: JC
authors.lastname: Ridway
authors.forename: C C
authors.initials: CC
authors.lastname: Platt
authors.forename: A J
authors.initials: AJ
authors.lastname: Rowlands
authors.forename: A
authors.initials: A
authors.lastname: Whitson
mesh_terms: D000328:Adult; D001855:Bone Marrow Diseases / Q000201:enzymology; D006402:Hematologic Diseases / Q000201:enzymology*; D006689:Hodgkin Disease / Q000201:enzymology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology; D007951:Leukemia, Myeloid / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology; D009101:Multiple Myeloma / Q000201:enzymology; D011087:Polycythemia Vera / Q000201:enzymology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology; D055728:Primary Myelofibrosis / Q000201:enzymology; D013920:Thrombocythemia, Essential / Q000201:enzymology; D008258:Waldenstrom Macroglobulinemia / Q000201:enzymology
chemical_list: D007770:L-Lactate Dehydrogenase