title: The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume.
abstract: Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.
authors.affiliation: Department of Gynecology, Charing Cross Hospital, London, United Kingdom.
authors.forename: J A
authors.initials: JA
authors.lastname: Eden
authors.forename: J
authors.initials: J
authors.lastname: Place
authors.forename: G D
authors.initials: GD
authors.lastname: Carter
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Alaghband-Zadeh
authors.forename: M E
authors.initials: ME
authors.lastname: Pawson
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004717:Endometrium / Q000187:drug effects*; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase / Q000187:drug effects*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D014599:Uterus / Q000187:drug effects*
chemical_list: D004967:Estrogens; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone