Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.
Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with mesna.
Pohl
J
J
Department of Cancer Research, ASTA Pharma AG, Bielefeld, Fed. Rep. of Germany.
Stekar
J
J
Hilgard
P
P
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D003556:Cystitis / Q000139:chemically induced* / Q000517:prevention & control; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D007069:Ifosfamide / Q000633:toxicity*; D008297:Male; D015080:Mesna / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D003520:Cyclophosphamide; C004656:chloroacetaldehyde; D000079:Acetaldehyde; D015080:Mesna; D007069:Ifosfamide