[Locoregional chemotherapy of liver tumors].
Experiences with different protocols of intraarterial chemotherapy in the treatment of primary or secondary liver malignancies in 38 cases were reported. The follow-up period was two years in all patients. Complications due to chemotherapy were observed only in very few patients. In 15 patients complications during chemotherapy from the implantable infusion system (Port a Cath) like leckage (n = 8), thrombosis of the system (n = 4), thrombosis of the hepatic artery (n = 1) and aneurysma of the hepatic artery (n = 2) occurred. Highest survival rates for the first and second year were achieved in patients with resectable liver metastases from colorectal cancer. A prophylactic implantation of an intraarterial catheter can be considered in patients in which a liver resection was performed because of multilocular uni- or bilateral metastases. CEA- and CA-19-9 levels did not correspond to the tumor progress in many cases.
Henne-Bruns
D
D
Chirurgischen und Medizinischen, Universitätsklinik Hamburg.
Marks
H G
HG
Marks
V
V
Weh
H J
HJ
Kremer
B
B
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage
D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil; D008727:Methotrexate
Lokoregionale Chemotherapie bei Lebertumoren.