title: Local murine recombinant gamma interferon enhances the acquisition of allergic contact dermatitis in the mouse.
abstract: Using the model of allergic contact dermatitis in mice, we have demonstrated that local administration of recombinant (r) murine gamma interferon (gamma-rIFN) to the sensitization site substantially enhances the acquisition of delayed-type hypersensitivity. Single doses of gamma-rIFN from 500 to 2,000 U immunopotentiate successfully, with a suggestion of a better response at the higher doses. The immunoadjuvant effect is lost when the injections of gamma-rIFN are at a site distant from the sensitization site. Kinetic studies imply that gamma-rIFN is most effective when given at the time of sensitization, but significant immunopotentiation can be seen when gamma-rIFN is given several days before or after sensitization.
authors.affiliation: Department of Medicine, Hahnemann University School of Medicine, Philadelphia, Pa.
authors.forename: H C
authors.initials: HC
authors.lastname: Maguire
authors.forename: M
authors.initials: M
authors.lastname: Guidotti
authors.forename: W P
authors.initials: WP
authors.lastname: Weidanz
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000008:administration & dosage; D005260:Female; D007114:Immunization; D007271:Injections, Intradermal; D007371:Interferon-gamma / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000008:administration & dosage; D011994:Recombinant Proteins
chemical_list: D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D010081:Oxazolone; D007371:Interferon-gamma; D004139:Dinitrofluorobenzene