Fixed-interval schedules for drug self-administration in the rat.
The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates comparable to those obtained with cocaine or food as reinforcer.
Corrigall
W A
WA
Addiction Research Foundation, Toronto, Ontario, Canada.
Coen
K M
KM
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D003932:Heroin / Q000008:administration & dosage; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule; D012646:Self Administration
D003932:Heroin; D003042:Cocaine