title: Chronic neutrophilic leukemia with dysplastic features. A new variant of the myelodysplastic syndromes.
abstract: We are reporting four patients who presented with a persistent increase of mature neutrophils and band forms, no monocytosis in repeated examinations and with dysplastic features in blood and bone marrow. Two of them developed acute myeloid leukemia (AML; FAB classification M1) and the other two were characterised by a progressively aggravating myelodysplasia. All the patients showed a poor response to treatment and died within a period of time ranging from 14 to 80 months after diagnosis. We are proposing the term chronic neutrophilic leukemia with dysplastic features (CNL-D) for this entity, and we believe that it represents a variant of the myelodysplastic syndromes.
authors.affiliation: Department of Internal Medicine, Patras University Medical School, Greece.
authors.forename: N C
authors.initials: NC
authors.lastname: Zoumbos
authors.forename: A
authors.initials: A
authors.lastname: Symeonidis
authors.forename: A
authors.initials: A
authors.lastname: Kourakli-Symeonidis
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000145:classification* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification*