The effect of continuous or pulsatile administration of oxytocin to ewes at 126 to 136 days' gestation on myometrial activity and fetal oxygenation.
Oxytocin was infused either continuously or in pulses to pregnant ewes to compare the responses of myometrial activity (contractures) and changes in fetal arterial PO2. Group 1 (n = 5) was infused with saline solution throughout the experiment. In group 2 (n = 5) oxytocin was infused continuously (160 microU.kg-1.min-1) for 7 days whereas group 3 (n = 5) ewes received 960 microU.kg-1.min-1 for 5 minutes every 30 minutes for 7 days. Contracture frequency increased in both oxytocin-infused groups. With continuous infusion contracture frequency returned to preinfusion levels during the last 4 days of infusion, whereas the pulsatile infusion contracture frequency remained increased throughout the infusion period. Fetal arterial PO2 was decreased throughout the 7 days of infusion in both oxytocin-infused groups. Pulsatile group fetal arterial PO2 levels remained decreased after the oxytocin infusion was stopped. These findings show: (1) Myometrial response to oxytocin in late pregnant ewes is influenced by the mode of administration; (2) administration of oxytocin to pregnant ewes resulted in a decrease in fetal PO2, and thus fetal hypoxemia cannot be attributed exclusively to increased contracture frequency.
Pimentel
G
G
Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Poore
E R
ER
Nathanielsz
P W
PW
D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous / Q000662:veterinary; D010100:Oxygen / Q000097:blood*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects*
D006454:Hemoglobins; D002245:Carbon Dioxide; D010121:Oxytocin; D010100:Oxygen