title: The determination of non-steroidal anti-inflammatory drugs by GC-MS-MS in equine urine.
abstract: Results are given for a more sensitive screening procedure for non-steroidal anti-inflammatory drugs using GC-MS-MS. By monitoring a selected characteristic reaction for each drug very low detection limits are reached even in a difficult biological matrix such as equine urine. Detection down to 5 ng ml-1 for ibuprofen, ibufenac, alclofenac, fenoprofen, ketoprofen, naproxen and diclofenac is possible in contrast to the 0.5 microgram ml-1 limit for normal GC-MS detection. Examples are given of real positive cases for diclofenac and ibuprofen.
authors.affiliation: Netherlands Institute for Drugs and Doping Research, Utrecht.
authors.forename: E G
authors.initials: EG
authors.lastname: de Jong
authors.forename: J
authors.initials: J
authors.lastname: Kiffers
authors.forename: R A
authors.initials: RA
authors.lastname: Maes
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D004300:Doping in Sports; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D012996:Solutions
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D012996:Solutions