Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction.
By using polymerase chain reaction and differential hybridization, point mutations of N-ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N-ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.
Mano
H
H
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Ishikawa
F
F
Hirai
H
H
Takaku
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D011905:Genes, ras; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*
D015342:DNA Probes; D004273:DNA, Neoplasm