title: Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. I. Taxonomy of the producing strain, fermentation, isolation and biological properties.
abstract: A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma.
authors.affiliation: Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Y H
authors.initials: YH
authors.lastname: Hsu
authors.forename: A
authors.initials: A
authors.lastname: Hirota
authors.forename: S
authors.initials: S
authors.lastname: Shima
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002460:Cell Line / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000032:analysis*; D051379:Mice; D008826:Microbial Sensitivity Tests; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D012988:Soil Microbiology
chemical_list: D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D008937:Mitomycins; C058997:myrocin C; D016685:Mitomycin