Persistence of Candida sp. 115 during hydrolysis of penicillin G and metabolism of phenylacetic acid.
The growth of Candida sp. 115 was investigated on the constituents of penicillin G hydrolysis reaction mixture. Neither penicillin G nor 6-aminopenicillanic acid was degraded or utilised for growth. The yeast accepted phenylacetic acid, sodium acetate and glucose as growth substrates. Phenylacetic acid was metabolised via p-hydroxy phenylacetic acid, which was the only accumulated metabolite. The enzymes responsible for hydroxylation of phenylacetic acid were induced by phenylacetic acid and sodium acetate.
Deshpande
B S
BS
Ambedkar
S S
SS
Sudhakaran
V K
VK
Narayanan
R A
RA
Shewale
J G
JG
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D002175:Candida / Q000254:growth & development*; D003470:Culture Media; D005947:Glucose / Q000378:metabolism; D006868:Hydrolysis; D010400:Penicillin G / Q000378:metabolism*; D010648:Phenylacetates / Q000378:metabolism*
D000085:Acetates; D003470:Culture Media; D010648:Phenylacetates; C025136:phenylacetic acid; D005947:Glucose; D019342:Acetic Acid; D010400:Penicillin G