title: [Metabolic changes associated with obesity in adults].
abstract: In order to find if the metabolic disorders more frequently found in our obese population were similar to the ones reported in the literature for other countries, a study was conducted in a group of 34 obese subjects (10 men and 24 women) whose only apparent alteration was a body mass index above 30 (mean value: 36.8 +/- 4.6) to obtain the relation between anthropometric measurements (Quetelet index, skinfold measures and waist/hip ratio) and plasma levels of nine biochemical parameters (including lipids, lipoproteins and glucose and insulin levels after an oral glucose load). The results revealed a tendency to the android distribution of fat in the female population, a significantly elevated triglyceride and total lipids levels and a decreased in HDL-cholesterol in both sexes. Hypercholesterolemia was present mainly in the male population. The most frequent dyslipidemia was Type IV (23%) followed by type IIb (15%). Practically none of the subjects had abnormal glycemic values after the glucose load, however the insulin levels were highly elevated in 80% of the patients, resulting in a great insulin/glucose ratios. Correlation analysis showed no association of the BMI with any biochemical parameter; only the insulin area was positively associated with anthropometric measures (mainly waist/hip ratio) and with the most altered biochemical parameter, the triglycerides. Variance analysis showed that only low HDL-cholesterol values were significantly different in patients presenting high blood pressure and familiar history of diabetes.
authors.affiliation: Escuela de Medicina, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
authors.forename: E
authors.initials: E
authors.lastname: Rincón
authors.forename: E
authors.initials: E
authors.lastname: Ryder
authors.forename: H
authors.initials: H
authors.lastname: Valbuena
authors.forename: N
authors.initials: N
authors.lastname: García de Zambrano
authors.forename: G
authors.initials: G
authors.lastname: Campos
authors.forename: L M
authors.initials: LM
authors.lastname: Morales
authors.forename: M
authors.initials: M
authors.lastname: Semprún de Fereira
authors.forename: I
authors.initials: I
authors.lastname: Wilhelm
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D012885:Skinfold Thickness
vernacular_title: Alteraciones metabólicas asociadas a la obesidad en adultos.