title: [Post-traumatic edema as a limiting factor in early functional treatment measures and its pharmacodynamic modification].
abstract: Post-traumatic oedema is a limiting factor of early functional exercise following fractures. A review of drug prophylaxis used in many clinical studies is given. A 30% reduction of oedema development following bimalleolar fractures was achieved with cyclooxigenase inhibitors (azapropazone) and aprotinin. It is pointed out that non-steroidal antiphlogistic drugs inhibit the collagen metabolism during the healing of rat skin-wounds.
authors.affiliation: Abteilung für Unfallchirurgie, Chirurgischen Universitätsklinik Kiel.
authors.forename: R
authors.initials: R
authors.lastname: Nissen
authors.forename: S
authors.initials: S
authors.lastname: Loeschke
authors.forename: A
authors.initials: A
authors.lastname: Peters
mesh_terms: D016512:Ankle Injuries / Q000534:rehabilitation*; D001032:Apazone / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004434:Early Ambulation; D004487:Edema / Q000534:rehabilitation*; D005593:Fracture Fixation, Internal; D006801:Humans; D011292:Premedication; D011446:Prospective Studies
chemical_list: D007611:Aprotinin; D001032:Apazone
vernacular_title: Das posttraumatische Odem als begrenzender Faktor frühfunktioneller Behandlungsmassnahmen und seine pharmakodynamische Beeinflussbarkeit.