title: Acute nonlymphocytic leukemia: evidence of clonogenic cells in peripheral blood in early complete remission.
abstract: We describe a patient with acute nonlymphocytic leukemia in whom chromosomal analysis showed a 8,21(q22;q22) translocation and who entered complete remission after one course of chemotherapy. During the post-chemotherapy aplastic phase blood-derived hemopoietic circulating stem cells were collected by continuous flow aphereses. Chromosomal analysis on the collected cells and on colonies (CFU-GM grown in agar) showed the same anomaly as was present at diagnosis in about 30% of those analyzed. This confirms the persistence of the malignant clone in the early phase of the clinical remission in acute nonlymphocytic leukemia.
authors.affiliation: Division of Hematology, IRCCS Policlinico S. Matteo, Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Castagnola
authors.forename: M
authors.initials: M
authors.lastname: Bonfichi
authors.forename: A
authors.initials: A
authors.lastname: Colombo
authors.forename: P
authors.initials: P
authors.lastname: Bernasconi
authors.forename: C
authors.initials: C
authors.lastname: Bernasconi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D007937:Leukapheresis; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D012074:Remission Induction; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D003561:Cytarabine; D003630:Daunorubicin