Absorption of recombinant human growth hormone (rhGH) following intraperitoneal instillation.
Recombinant human growth hormone (rhGH) was instilled intraperitoneally (i.p.) in six children undergoing continuous cycling peritoneal dialysis (CCPD). Immediate absorption was noted with either 0.250 mg/kg, 0.125 mg/kg, or 0.050 mg/kg of rhGH. Peak serum growth hormone (GH) levels occurred 4 and 8 h following i.p. administration, and the serum GH levels had returned to baseline values at 24 h. In one patient, a higher dosage demonstrated adequate absorption, whereas the lower dosage produced a flat absorption curve. These data indicate that daily i.p. administration of rhGH could be utilized in clinical trials directed toward improving the growth velocity of children undergoing CCPD.
Fine
R N
RN
Department of Pediatrics, UCLA Center for the Health Sciences.
Fine
S E
SE
Sherman
B M
BM
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019382:Human Growth Hormone; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000379:methods*; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000627:therapeutic use
D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone