Transient neonatal tyrosinaemia.
Children who had presented with transient neonatal tyrosinaemia (TNT) were compared with a group of unaffected controls at 7-9 years of age. A comprehensive psychometric assessment revealed significant differences between the groups in adaptive behaviour, psycholinguistic abilities, and speed of learning. In nearly all components of the tests used, higher levels of TNT were associated with lower levels of performance. This study demonstrates that TNT, a condition commonly regarded as benign in the short term, has long-term effects which may be detrimental to the child in school.
Rice
D N
DN
Department of Community Health, School of Medicine, University of Auckland, New Zealand.
Houston
I B
IB
Lyon
I C
IC
Macarthur
B A
BA
Mullins
P R
PR
Veale
A M
AM
Guthrie
R
R
D000223:Adaptation, Psychological; D000592:Amino Acid Metabolism, Inborn Errors / Q000097:blood / Q000523:psychology*; D002648:Child; D003071:Cognition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007804:Language Development; D007858:Learning; D008297:Male; D014443:Tyrosine / Q000097:blood*
D014443:Tyrosine