title: [Tissue-type plasminogen activator--a fibrinolytic preparation].
abstract: Plasminogen tissue activator is a physiological component of the fibrinolytic system of the organism. A positive feature of its effect is its ability to activate fibrinolysis exclusively in the thrombus zone, practically without influencing this process in the general blood flow. At present the preparation was obtained by the biotechnological method. The clinical trials indicate its high efficiency. There was revealed the possibility of modification of the plasminogen tissue activator molecule that permits enhancement of its thrombolytic effect.
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D005342:Fibrinolysis / Q000187:drug effects; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D013927:Thrombosis / Q000188:drug therapy; D010959:Tissue Plasminogen Activator / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D010959:Tissue Plasminogen Activator
vernacular_title: Tkanevoĭ aktivator plazminogena--fibrinoliticheskiĭ preparat.