title: Long-term fluoxetine treatment of a large number of obsessive-compulsive patients.
abstract: A group of 75 outpatients suffering from obsessive-compulsive disorder began treatment with the bicyclic antidepressant fluoxetine in an open clinical setting. Their progress was evaluated using the Hamilton Depression Scale, the Hamilton Anxiety Scale, and a global scale of severity of obsessive-compulsive symptoms. The group showed significant improvement on all measures. This improvement continued and was progressive over a 5-month period. Weight loss was present but not significant by the end of the 5-month period.
authors.affiliation: Department of Psychiatry, Lenox Hill Hospital, New York, New York.
authors.forename: R
authors.initials: R
authors.lastname: Levine
authors.forename: J S
authors.initials: JS
authors.lastname: Hoffman
authors.forename: E D
authors.initials: ED
authors.lastname: Knepple
authors.forename: M
authors.initials: M
authors.lastname: Kenin
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D005473:Fluoxetine