title: Unusual complications of antithyroid drug therapy: four case reports and review of literature.
abstract: Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described. The literature related to antithyroid drug side effects and the mechanisms for their occurrence are reviewed and the efficacy and complications of thyroidectomy and radioiodine compared to those of antithyroid drugs. It is concluded that in most circumstances 131I is the therapy of choice for hyperthyroidism.
authors.affiliation: Department of Internal Medicine, University of Wisconsin, Madison.
authors.forename: B
authors.initials: B
authors.lastname: Baker
authors.forename: B
authors.initials: B
authors.lastname: Shapiro
authors.forename: L M
authors.initials: LM
authors.lastname: Fig
authors.forename: D
authors.initials: D
authors.lastname: Woodbury
authors.forename: J C
authors.initials: JC
authors.lastname: Sisson
authors.forename: W H
authors.initials: WH
authors.lastname: Beierwaltes
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008713:Methimazole / Q000009:adverse effects*; D009336:Necrosis; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D008713:Methimazole; D011441:Propylthiouracil