Antileishmanial effect of free and encapsulated sinefungin against Leishmania donovani infections in BALB/c mice.
Sinefungin, a C-nucleoside antibiotic, displays a high antiparasitic action. The effect of free and microencapsulated sinefungin was compared on BALB/c mice infected with Leishmania donovani; the encapsulated form proved more effective by one order of magnitude.
Neal
R A
RA
London School of Hygiene and Tropical Medicine, Herts, Great Britain.
Iwobi
M V
MV
Robert-Gero
M
M
D000241:Adenosine / Q000031:analogs & derivatives; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C
D000981:Antiprotozoal Agents; D002214:Capsules; D000241:Adenosine; C006235:sinefungin