The effect of triiodothyronine on the association of the rat apolipoprotein A-I, C-III and A-IV genes with the nuclear matrix.
The association of apolipoprotein genes with the nuclear matrix of rat liver has been studied. The proportion of the apolipoprotein (apo) A-I, A-IV, C-III and E genes and the albumin gene associated with the matrix in normal rat liver was approximately 11%. In hypothyroid rats, the association of the apo A-I and apo A-IV genes with the matrix was reduced to 1.3% and 2.1% respectively, while in hyperthyroid rats, the association increased to 59% and 39% respectively. In contrast, the association of the apo C-III gene, which is located between the A-I and A-IV genes on chromosome 11, was not significantly affected by thyroid status. The association of the apo E and albumin genes with the matrix was also unaltered by changes in thyroid status. The increased association of the apo A-I and A-IV genes with the nuclear matrix of hyperthyroid animals accompanies the transcriptional activation of these genes by thyroid hormones.
Apostolopoulos
J J
JJ
Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Australia.
La Scala
M J
MJ
Shen
P Y
PY
Howlett
G J
GJ
D000418:Albumins / Q000235:genetics; D000818:Animals; D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A / Q000235:genetics*; D001056:Apolipoproteins C / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D005786:Gene Expression Regulation / Q000187:drug effects; D005796:Genes; D008099:Liver / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*
D000418:Albumins; D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001056:Apolipoproteins C; D001057:Apolipoproteins E; C022205:apolipoprotein A-IV; D014284:Triiodothyronine