[Systematic detection of anti-erythrocyte alloimmunization during pregnancy. Experience at the Lyon Regional Blood Transfusion Center].
In France, relative increases in hemolytic disease of the newborn (HDN) due to non anti-D maternal alloimmunization is linked to a systematic search and prevention of an anti-D alloimmunization in Rh negative women during and after pregnancy. In May 1985, detection of anti-red blood cell alloantibodies in all pregnant women has been ordered by a new law. We have observed the efficiency of this law by studying the number of HDN with anti-D and non anti-D maternal alloimmunization detected before and after delivery during the years 1984 and 1986. Our results show that this law is well used. Nevertheless, this work demonstrates that often clinicians omit to set cord blood aside for hemoglobin and bilirubinemia concentration determinations. Because these two parameters are very important in establishing the severity of HDN and therapeutic management, improvements are necessary.
Moncharmont
P
P
CRTS de Lyon, Hôpital Edouard-Herriot.
Juron-Dupraz
F
F
Vignal
M
M
Rigal
D
D
D000328:Adult; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D011247:Pregnancy / Q000276:immunology*; D012203:Rh Isoimmunization
D007518:Isoantibodies
Dépistage systématique de l'allo-immunisation anti-érythrocytaire au cours de la grossesse. L'expérience du Centre Régional de Transfusion Sanguine de Lyon.