title: ["Chimeric" antibiotics, daunorubicin and its analogs N-acylated with bruneomycin (Streptonigrin)].
abstract: Anthracycline antibiotics (daunorubicin, carminomycin and doxorubicin) N-acylated with antibiotic bruneomycin (streptonigrin) have been obtained from the parent compounds upon treatment with N, N'-dicyclohexylcarbodiimide and N-hydroxysuccinimide. These "chimeric" antibiotics are less active both in vitro and in vivo than the parent antibiotics. This demonstrates the stability of the intermolecular amide linkage in these compounds towards chemical and enzymatic hydrolysis as well as their inability to interact with corresponding receptors in contrast to less hindered derivatives of the parent antibiotics.
authors.forename: V V
authors.initials: VV
authors.lastname: Tolstikov
authors.forename: N V
authors.initials: NV
authors.lastname: Kozlova
authors.forename: I V
authors.initials: IV
authors.lastname: Iartseva
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaia
mesh_terms: D000215:Acylation; D001412:Bacillus subtilis / Q000187:drug effects; D002360:Carubicin / Q000378:metabolism* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D004024:Dicyclohexylcarbodiimide; D004317:Doxorubicin / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013308:Streptonigrin / Q000378:metabolism*; D013388:Succinimides
chemical_list: D013388:Succinimides; D013308:Streptonigrin; D004024:Dicyclohexylcarbodiimide; D004317:Doxorubicin; D002360:Carubicin; C001426:N-hydroxysuccinimide; D003630:Daunorubicin
vernacular_title: "Khimernye antibiotiki"--daunorubitsin i ego analogi, N-atsilirovannye bruneomitsinom (Streptonigrinom).