title: Arginine vasopressin and acute, intravascular volume expansion in the human fetus.
abstract: There is presently no information concerning the ontogeny and control of arginine vasopressin (AVP) in the human fetus. AVP was measured in 22 nonanemic control fetuses and 7 fetuses with hemolytic anemia undergoing 13 intravascular transfusions. Each transfused fetus received pancuronium (0.3 mg/kg) and furosemide (2 mg/kg). Compared to the control group of nonanemic fetuses with hemolytic disease, AVP was significantly lower in the anemic fetus prior to transfusion (2.6 +/- 0.4 microU/ml versus 10.4 +/- 4.1 microU/ml, p less than 0.05). This suggests that hemolytic anemia is associated with a relative increase in fetal intravascular volume. Intravascular transfusion was associated with a significant increase in AVP (p less than 0.05). These findings could not be explained by changes in either blood pressure, plasma osmolality, or fetal oxygenation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa School of Medicine, Iowa City.
authors.forename: C P
authors.initials: CP
authors.lastname: Weiner
authors.forename: F
authors.initials: F
authors.lastname: Smith
authors.forename: J E
authors.initials: JE
authors.lastname: Robillard
mesh_terms: D000743:Anemia, Hemolytic / Q000503:physiopathology; D001127:Arginine Vasopressin / Q000378:metabolism*; D001805:Blood Transfusion, Intrauterine; D005315:Fetal Diseases / Q000503:physiopathology; D005333:Fetus / Q000502:physiology*; D006801:Humans; D009994:Osmolar Concentration; D010953:Plasma Volume / Q000502:physiology*
chemical_list: D001127:Arginine Vasopressin