title: Chronic renal failure and growth.
abstract: Growth was assessed in 38 prepubertal children with chronic renal failure for a mean (range) of 2.3 (1-4) years. At first clinic visit their mean (range) glomerular filtration rate was 17 (7-35) ml/min/1.73 m2, their mean (range) age was 3.4 (0.2-9.1) years, and 23 (61%) were greater than two standard deviations below the mean for height. After intensive medical management of their chronic renal failure, half of the children who presented before 2 years of age showed appreciable catch up growth. Only a slow improvement in growth occurred in most children presenting over 2 years of age. At final assessment, the mean (range) glomerular filtration rate was 15 (6-42) ml/min/1.73(2) and 20 (53%) were greater than two standard deviations below the mean for height. There was no correlation between glomerular filtration rate and growth. There remained a group of children who continued to grow poorly. Many of these were of low birth weight, and had dysplastic kidneys.
authors.affiliation: Evelina Children's Hospital, United Medical School, London.
authors.forename: L
authors.initials: L
authors.lastname: Rees
authors.forename: S P
authors.initials: SP
authors.lastname: Rigden
authors.forename: G M
authors.initials: GM
authors.lastname: Ward
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D004750:Enteral Nutrition; D005260:Female; D005919:Glomerular Filtration Rate; D006130:Growth Disorders / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D008297:Male