title: [Pharmacologic aspects of sleep disorders].
abstract: Sleep disorders are becoming a major issue. Insomnia affects a substantial part of the population and may compromise individual quality of life. The principal existing hypnotic drugs, Barbiturates and Benzodiazepines are not safely. They have modes of action which results in the action of common mechanism: facilitating neurotransmission in GABAergic synapses. Stimulation of GABA receptors of the A type opens chloride ion channels which inhibits the ability of neurons to conduct nerve impulse. The clinical effects resulting which induce anticonvulsant, muscle relaxant, anxiolytic, sedative, hypnotic and amnesic effects are discussed.
authors.affiliation: Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon.
authors.forename: J P
authors.initials: JP
authors.lastname: Kantelip
authors.forename: P
authors.initials: P
authors.lastname: Magnin
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000494:pharmacology / Q000627:therapeutic use; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use; D002712:Chlorides / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D012890:Sleep / Q000502:physiology; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D001463:Barbiturates; D002712:Chlorides; D007473:Ion Channels; D011963:Receptors, GABA-A; D001569:Benzodiazepines
vernacular_title: Pharmacologie du sommeil: les insomnies.