[The destruction of perikaryas of the mesencephalic reticular formation and the posterior hypothalamus does not cause major disorders of awakening in the cat].
Ibotenic acid microinjections have been realized at the level of the mesencephalic reticular formation and the posterior hypothalamus in 7 cats. This technique has led to a quasi-total destruction of cell bodies in the two areas (including the histaminergic neurons). 2 to 3 days after such lesions, there were no major effects on behavioral waking. These results do not favor the hypothesis of the existence of a waking system at the level of the mesencephalic reticular formation and/or posterior hypothalamus.
Denoyer
M
M
Département de Médecine expérimentale, I.N.S.E.R.M., Lyon.
Buda
C
C
Jouvet
M
M
D000818:Animals; D002415:Cats; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000187:drug effects / Q000502:physiology*; D007051:Ibotenic Acid / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology*; D014851:Wakefulness
D007051:Ibotenic Acid
La destruction des périkaryas de la formation réticulée mésencéphalique et de l'hypothalamus postérieur n'entraîne pas de troubles majeurs de l'éveil chez le chat.