title: The killing action of fleroxacin upon Bacteroides fragilis.
abstract: The killing kinetics of fleroxacin against four strains of Bacteroides fragilis were investigated. Viable counts were determined from 0 to 24 h after exposure to fleroxacin at multiples of the MIC. A one to three log reduction in viable count was observed after 2 h at 8 mg/l fleroxacin, and a more rapid rate of killing was seen at greater concentrations of the antimicrobial agent. An increase in cell length was observed at concentrations at and above the MIC from 2 h after exposure. The presence of a bacteriostatic concentration of chloramphenicol had negligible influence on viability but inhibited cell elongation.
authors.affiliation: Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Griggs
authors.forename: L J
authors.initials: LJ
authors.lastname: Piddock
authors.forename: R
authors.initials: R
authors.lastname: Wise
mesh_terms: D000900:Anti-Bacterial Agents; D001441:Bacteroides fragilis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D016576:Fleroxacin; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D016576:Fleroxacin