title: Light-chain nephropathy. A report of 2 cases.
abstract: Two cases of renal impairment caused by the deposition of monoclonal immunoglobulin light-chain determinants in the glomerular mesangium and basement membranes as well as in the tubular basement membranes of the kidney are described (light-chain nephropathy). Both cases were associated with myeloma. Examinations by light microscopy, immunohistochemistry and electron microscopy are also described. Differential diagnoses on light microscopy include diabetic glomerulosclerosis (Kimmelstiel-Wilson lesions), amyloidosis and mesangiocapillary glomerulonephritis type 1.
authors.affiliation: Department of Anatomical Pathology, University of Natal and King Edward VIII Hospital, Durban.
authors.forename: K
authors.initials: K
authors.lastname: Cooper
authors.forename: B C
authors.initials: BC
authors.lastname: Nathoo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000209:etiology*; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D012598:Sclerosis
chemical_list: D007147:Immunoglobulin Light Chains