Blunted growth hormone response to peripheral infusion of human growth hormone-releasing factor in patients with panic disorder.
Patients with panic disorder (N = 11) and age- and sex-matched normal control subjects (N = 11) were challenged with human growth hormone-releasing factor (GH-RF) (1 microgram/kg i.v.) or placebo in random order. The control subjects had significantly increased plasma growth hormone (GH) levels after GH-RF infusion whereas panic disorder patients did not. At 15 and 30 minutes after GH-RF infusion, GH concentrations were significantly higher in the control subjects than in the patients. These findings with GH-RF extend findings from earlier reports that patients with panic disorder show blunted GH response to phobic stimulation and clonidine.
Rapaport
M H
MH
Department of Psychiatry, University of California, San Diego, La Jolla.
Risch
S C
SC
Gillin
J C
JC
Golshan
S
S
Janowsky
D S
DS
D000328:Adult; D000379:Agoraphobia / Q000097:blood* / Q000175:diagnosis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010698:Phobic Disorders / Q000097:blood*; D011897:Random Allocation
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone