Rate of action of schistosomicides in mice infected with Schistosoma mansoni.
Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.
Katz
N
N
Centro de Pesquisas René Rachou/FIOCRUZ, Brasil.
Dias
E P
EP
de Souza
C P
CP
Bruce
J I
JI
Coles
G C
GC
D000818:Animals; D051379:Mice; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects*; D012556:Schistosomicides / Q000493:pharmacokinetics*
D012556:Schistosomicides