[Graft-versus-host disease associated with transfusions. Detection of 2 cases by skin biopsy in children].
The first case was a 2 year-old girl with Blackfan-Diamond anemia who developed the immune reaction two weeks after receiving two transfusions of sedimented erythrocytes. HLA typing of lymphocytes showed the presence of three HLA-A, two of which were present in the donors. The second was a newborn who initially received an exchange transfusion and three weeks later another transfusion of whole blood. Both cases exhibited a severe bone marrow involvement and a skin biopsy with the pattern of keratinocyte apoptosis and lymphocyte satellitosis. These histological findings although highly suggestive must be evaluated in the appropriate clinical setting.
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D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology*; D015234:HLA-A Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D012867:Skin / Q000473:pathology*; D065227:Transfusion Reaction
D015234:HLA-A Antigens
Enfermedad injerto contra huésped asociada a transfusiones. Reconocimiento de dos casos infantiles por la biopsia de piel.