Occurrence of both neurofibromatoses 1 and 2 in the same individual with a rapidly progressive course.
We describe a family in which the father had neurofibromatosis-1 and the mother neurofibromatosis-2. Their son presented at the age of 8 years with bilateral acoustic neuromas, meningioma, and numerous neurofibromas. We believe that the occurrence of the genes responsible for both forms of neurofibromatosis in the same patient had a synergistic effect on the early rapid growth of neurofibromatoses 1 and 2 neoplasms.
Sadeh
M
M
Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Martinovits
G
G
Goldhammer
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D009423:Nervous System Neoplasms / Q000235:genetics*; D009456:Neurofibromatosis 1 / Q000235:genetics*; D009464:Neuroma, Acoustic / Q000000981:diagnostic imaging / Q000235:genetics*; D014057:Tomography, X-Ray Computed