[Adoptive transfer of immunity against Nippostrongylus brasiliensis in mice. In vitro restimulation of immune cells before their transfer].
When mesenteric lymph node cells from infected mice were stimulated during an in vitro culture with exoantigens or with a purified protective antigen of Nippostrongylus brasiliensis, a drop was noted in the number of cells required to transfer protection to new mice. A maximal effect was already obtained after 4 hrs. of culture, but irradiated cells or cells from another mouse strain were unable to mediate this transfer. T cells were more effective than B cells in transferring the protection.
Rhalem
A
A
Station de Virologie et d'Immunologie, I.N.R.A., Centre de Recherches de Jouy-en-Josas.
Bourdieu
C
C
Luffau
G
G
Péry
P
P
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002452:Cell Count; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D009559:Nippostrongylus / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D000953:Antigens, Protozoan
Transfert adoptif de l'immunité contre Nippostrongylus brasiliensis chez la souris. Effet d'une restimulation in vitro des cellules immunes avant leur transfert.