[Effects of weak solutions of aldehydes on EEG changes in rats].
Alternations of EEG have been investigated after single intraarterial infusion of formaldehyde, glutaric aldehyde and its mixture in 50 adult male rats. The dissolved solutions of aldehydes were shown to have complicated inhibitive activity which consists of two phases. The first phase of EEG inhibition rapidly develops and it isn't very long in its duration. The second one is much more durable. Formaldehyde causes the first phase of inhibition in general, though glutaric aldehyde promotes especially the appearance of the second phase. The mixture of two aldehydes demonstrates synergic activity which is shown as significant increase of EEG inhibition as compared to individual inhibitive activity of aldehydes. The inhibitive influence of aldehydes is fully reversible, nonspecific and doesn't cause post-experimental disorders. The highest effect of brain protection from ischaemia damages coincides with development of maximum inhibition of specific brain functions during the second phase of EEG depression.
Khokhlov
A V
AV
Bashilov
I A
IA
Tel'pukhov
V I
VI
Lapkina
T I
TI
D000447:Aldehydes / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology; D004338:Drug Combinations; D004357:Drug Synergism; D004569:Electroencephalography; D005557:Formaldehyde / Q000008:administration & dosage / Q000494:pharmacology; D005976:Glutaral / Q000008:administration & dosage / Q000494:pharmacology; D007261:Infusions, Intra-Arterial; D007552:Isotonic Solutions; D008297:Male; D051381:Rats
D000447:Aldehydes; D004338:Drug Combinations; D007552:Isotonic Solutions; D005557:Formaldehyde; D005976:Glutaral
Vliianie slabykh rastvorov al'degidov na izmeneniia EEG krys.