title: Topical nitroglycerin: a potential treatment for impotence.
abstract: The effect of 2 per cent nitroglycerin paste applied to the penile shaft of impotent subjects was evaluated in a placebo controlled double-blind study under laboratory conditions. After application of nitroglycerin paste or a placebo ointment base, penile tumescence was recorded through a strain gauge transducer while subjects viewed an erotic video presentation. Relative to the placebo paste the number of subjects demonstrating an increase in penile circumference after nitroglycerin (18 of 26) was significantly different than all other outcome possibilities (p less than 0.05). Noninvasive vascular assessment by ultrasonography demonstrated an increase in diameter and blood flow in the cavernous arteries after application of nitroglycerin paste. Nitroglycerin paste increases blood flow in the cavernous arteries and improves tumescence after erotic stimulation. This agent may represent a new therapy for impotence.
authors.affiliation: Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Owen
authors.forename: F
authors.initials: F
authors.lastname: Saunders
authors.forename: C
authors.initials: C
authors.lastname: Harris
authors.forename: J
authors.initials: J
authors.lastname: Fenemore
authors.forename: K
authors.initials: K
authors.lastname: Reid
authors.forename: D
authors.initials: D
authors.lastname: Surridge
authors.forename: M
authors.initials: M
authors.lastname: Condra
authors.forename: A
authors.initials: A
authors.lastname: Morales
mesh_terms: D000287:Administration, Topical; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000098:blood supply; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects
chemical_list: D005996:Nitroglycerin