[A clinical study of amino acid metabolism in cancerous hypoproteinemia--the role of branched chain amino acids (BCAA) and appropriate compositions of BCAA in parenteral nutrition].
In order to determine the nutritional effects of BCAA compositions in the treatment of cancerous hypoproteinemia, the appropriate ratio of I-leu: Leu: Val and the proportion of BCAA to Total Amino Acids were investigated. As for results, indices such as the serum albumin, the RBP and N-balance quickly recovered to normal levels when the ratio of I-leu: Leu: Val was 1.0:1.8:1.0 and the proportion o BCAA to TAA was 31%. These composition thus may be suitable for the treatment of cancerous hypoproteinemia.
Fukui
S
S
Dept. of Gastroenterology, Fujita-Gakuen Univ.
Aoki
H
H
Mizushima
Y
Y
Suzuki
Y
Y
Fujii
J
J
Ikeyama
A
A
Taki
K
K
Hayasaka
H
H
D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007019:Hypoproteinemia / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D007532:Isoleucine / Q000008:administration & dosage / Q000627:therapeutic use; D007930:Leucine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total / Q000379:methods; D011228:Prealbumin / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014633:Valine / Q000008:administration & dosage / Q000627:therapeutic use
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014168:Transferrin; D007532:Isoleucine; D007930:Leucine; D014633:Valine; D009584:Nitrogen