title: Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation.
abstract: The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3,5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the characteristic feature of epiderstatin is that it has a piperidone ring instead of a cyclohexanone ring.
authors.affiliation: RIKEN, The Institute of Physical and Chemical Research, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sonoda
authors.forename: H
authors.initials: H
authors.lastname: Osada
authors.forename: M
authors.initials: M
authors.lastname: Uramoto
authors.forename: J
authors.initials: J
authors.lastname: Uzawa
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D000903:Antibiotics, Antineoplastic; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D010880:Piperidines; D010881:Piperidones; D011728:Pyridones; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis
chemical_list: D000903:Antibiotics, Antineoplastic; D010880:Piperidines; D010881:Piperidones; D011728:Pyridones; C061874:epiderstatin; D004815:Epidermal Growth Factor