title: Antecedent angina: a predictor of residual stenosis after thrombolytic therapy.
abstract: Patients with a significant residual stenosis after thrombolytic therapy are believed by many to be at increased risk for repeat ischemic events and may be candidates for prompt angiography and revascularization. To test the hypothesis that patients with antecedent angina (Canadian classes I to IV, greater than or equal to 24 h before myocardial infarction) are more likely to have a significant residual stenosis (greater than or equal to 60% diameter reduction) than are those without antecedent angina, the coronary angiograms of 82 consecutive patients undergoing routine angiography after thrombolytic therapy were reviewed. Compared with the patients without antecedent angina, the group with antecedent angina had an increased mean stenosis (74% versus 58%) and more multivessel disease (44% versus 5%). The sensitivity and specificity of a clinical history of antecedent angina predicting the presence of a significant residual stenosis were 75% and 96%, respectively; the positive predictive accuracy was 98%. These data suggest that antecedent angina can be used to identify a high risk subgroup whose condition may warrant routine coronary angiography.
authors.affiliation: Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts.
authors.forename: B A
authors.initials: BA
authors.lastname: Bergelson
authors.forename: N A
authors.initials: NA
authors.lastname: Ruocco
authors.forename: T J
authors.initials: TJ
authors.lastname: Ryan
authors.forename: B R
authors.initials: BR
authors.lastname: Hankin
authors.forename: A K
authors.initials: AK
authors.lastname: Jacobs
authors.forename: D P
authors.initials: DP
authors.lastname: Faxon
mesh_terms: D000787:Angina Pectoris / Q000150:complications*; D002908:Chronic Disease; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D013300:Streptokinase / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D013300:Streptokinase; D010959:Tissue Plasminogen Activator