[The dynamics of the analgesic effect of non-steroidal antirheumatic drugs. Ibuprofenlysinate versus diclofenac].
In a double-blind clinical study, the analgesic effects of ibuprofen-lysinsalt and diclofenac were compared in 59 patients with rheumatoid arthritis. In the first phase, the patients were given either 1,000 mg ibuprofen-lysinsalt or 50 mg diclofenac at 8.00 a.m. Pain intensity was assessed by the patient with the aid of the visual analog scale (VAS) and a sliding numerical scale. With respect to the rate of onset of the effect and the course of the pain, no statistically significant differences were seen between the two drugs. In a second phase, in which the already mentioned doses of the drugs were administered 3 times a day for 7 days, there was again no significant difference in pain. Drug tolerance was considered very good by 90% of the ibuprofen-lysinsalt group, and 67% of the diclofenac group. Ibuprofen-lysinsalt is a universal, well-tolerated analgetic which can also be used to combat arthritic pain. The somewhat better analgesic effect of ibuprofen-lysinsalt was too small to be statistically significant.
Pavelka
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Pavelka
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Trnavsky
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D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010147:Pain Measurement; D011897:Random Allocation
D004008:Diclofenac; D008239:Lysine; C016106:solufenum; D007052:Ibuprofen
Dynamik der analgetischen Wirkung von nicht-steroidalen Antirheumatika. Ibuprofen-Lysinat versus Diclofenac.