title: Acute renal failure in the "Comrades Marathon" runners.
abstract: This study investigated the clinical and biochemical features of acute renal failure in marathon runners. Over a period of 18 years (1969-1986), 19 patients were admitted to the renal unit. The histories and biochemical data of 4 patients seen in 1986 are described. The pathophysiology of acute renal failure is multifactorial and is the combined effect of rhabdomyolysis, dehydration, hypotension, nonsteroidal anti-inflammatory drugs, and hyperuricaemia. Efforts to correct dehydration have resulted in a decrease in the incidence of acute renal failure. The use of nonsteroidal anti-inflammatory drugs is to be deprecated and efforts should be made to publicize this harmful effect.
authors.affiliation: Department of Medicine, University of Natal, Durban, Republic of South Africa.
authors.forename: Y K
authors.initials: YK
authors.lastname: Seedat
authors.forename: N
authors.initials: N
authors.lastname: Aboo
authors.forename: S
authors.initials: S
authors.lastname: Naicker
authors.forename: I
authors.initials: I
authors.lastname: Parsoo
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D000328:Adult; D006801:Humans; D008297:Male; D010807:Physical Endurance; D011379:Prognosis; D006435:Renal Dialysis; D012420:Running / Q000293:injuries*