Consistent occurrence of a 19p+ marker chromosome and loss of 11p material in ovarian seropapillary cystadenocarcinomas.
Cytogenetic analysis of short-term cultures from 11 moderately to poorly differentiated ovarian seropapillary cystadenocarcinomas revealed clonal chromosomal abnormalities in nine tumors. Two bands were involved in structural rearrangements in more than half of the tumors. The band most frequently affected was 19p13; rearrangements giving rise to a 19p+ marker chromosome were found in seven tumors, and in four of them the 19p+ markers appeared to be identical. Structural rearrangements resulting in loss of 11p13-11pter material were found in six tumors.
Pejovic
T
T
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Heim
S
S
Mandahl
N
N
Elmfors
B
B
Flodérus
U M
UM
Furgyik
S
S
Helm
G
G
Willén
H
H
Mitelman
F
F
D002454:Cell Differentiation / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D003536:Cystadenocarcinoma / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*; D011003:Ploidies; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014178:Translocation, Genetic / Q000235:genetics
D005819:Genetic Markers