title: Usefulness of sustained-release diltiazem for stable angina pectoris.
abstract: Sustained-release diltiazem, 120 and 180 mg twice daily, was assessed in a multicenter, double-blind, randomized, placebo-controlled trial in 65 stable angina patients with exercise-induced ST depression. Exercise testing was performed 12 +/- 1 hours after the last dose at the end of each of the 3 treatment weeks. Both dose levels of drug reduced spontaneous angina (p less than 0.001) and increased exercise duration (p less than 0.01) and time to 1-mm ST depression (p less than 0.001). No differences were noted between the 2 dose levels. Rate-pressure product at maximal exercise was similar for the 3 groups. Only 1 patient terminated the study because of adverse drug effects; severe adverse effects occurred in 1 placebo and 1 low-dose period. Sustained-release diltiazem is safe and efficacious monotherapy for patients with stable angina.
authors.affiliation: Canadian Multicenter Diltiazem Study Group.
authors.forename: W P
authors.initials: WP
authors.lastname: Klinke
authors.forename: M
authors.initials: M
authors.lastname: Juneau
authors.forename: M
authors.initials: M
authors.lastname: Grace
authors.forename: W J
authors.initials: WJ
authors.lastname: Kostuk
authors.forename: P
authors.initials: P
authors.lastname: Pflugfelder
authors.forename: C R
authors.initials: CR
authors.lastname: Maranda
authors.forename: W
authors.initials: W
authors.lastname: Warnica
authors.forename: C
authors.initials: C
authors.lastname: Chin
authors.forename: L
authors.initials: L
authors.lastname: Annable
authors.forename: E E
authors.initials: EE
authors.lastname: Dempsey
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D004110:Diltiazem; D005996:Nitroglycerin