Interspecific protoplast fusion of Streptomyces hygroscopicus var. yingchengenisis with Streptomyces qingfengmyceticus and biological characterization of their recombinants.
The frequency of recombination between Streptomyces hygroscopicus var. yingchengensis and Streptomyces qingfengmyceticus as a result of interspecific protoplast fusion was 4.5 x 10(-4). Characterization of biological properties revealed differences in spore mass color, drug resistance, antimicrobial activity, and antibiotic production capacity between the recombinants and their parents. Two recombinant strains, FL-42 and FL-48, exhibited production of the antibiotics originally elaborated by the two parents individually. They also produced two compounds with antimicrobial activity that their parents could not synthesize.
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Agricultural Antibiotic Laboratory, Huazhong Agricultural University, Wuhan.
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D002854:Chromatography, Paper; D004352:Drug Resistance, Microbial / Q000235:genetics; D011523:Protoplasts / Q000187:drug effects / Q000378:metabolism*; D011995:Recombination, Genetic; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents