title: A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species.
abstract: In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
authors.forename: D
authors.initials: D
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Henikoff
mesh_terms: D000228:Adenine Phosphoribosyltransferase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D007438:Introns; D008969:Molecular Sequence Data; D010430:Pentosyltransferases / Q000235:genetics*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing; D013045:Species Specificity
chemical_list: D012322:RNA Precursors; D004247:DNA; D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase