Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--II. Biological distributions of 99mTc-DMAD components isolated by anion exchange HPLC.
HPLC isolated components of 99mTc(NaBH4)-DMAD mixtures exhibit significantly different biological properties than do analogous components of 99mTc(NaBH4)-MDP and 99mTc(NaBH4)-HEDP mixtures. Most importantly, 99mTc-DMAD components desorb from normal bone whereas analogous 99mTc-MDP and 99mTc-HEDP components do not. However, within an osteogenic rat model, an HPLC isolated 99mTc-DMAD component does not exhibit an unusually high abnormal/normal tibia uptake ratio.
Holland
M E
ME
Department of Chemistry, University of Cincinnati, OH 45221.
Bugaj
J
J
Heineman
W R
WR
Deutsch
E
E
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D001894:Borohydrides / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004164:Diphosphonates / Q000493:pharmacokinetics*; D012968:Etidronic Acid / Q000493:pharmacokinetics; D005260:Female; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds; D010012:Osteogenesis; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000493:pharmacokinetics; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics; D014018:Tissue Distribution
D001894:Borohydrides; D004164:Diphosphonates; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C059662:technetium Tc 99m (sodium borohydride)-dimethylaminomethylene diphosphonate; C019561:technetium Tc 99m etidronate; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate