No difference between smoking lung cancer patients and smoking controls in the frequency of spontaneous and mitomycin C induced chromosome aberrations in lymphocytes.
Lymphocytes from 21 male smokers, 10 untreated lung cancer patients, and 11 controls were cultured with and without exposure to mitomycin C. There were no differences between the chromosome aberration frequencies in the two groups: the spontaneous aberration frequency was 8.5% among patients and 8.4% among controls, whereas after mitomycin C induction the corresponding frequencies were 25.5% and 24.6%, respectively.
Johansson
M
M
Orndal
C
C
D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D012907:Smoking / Q000235:genetics*
D008937:Mitomycins; D016685:Mitomycin