title: Effect of Norplant contraceptive use on hemoglobin, packed cell volume and menstrual bleeding patterns.
abstract: A study was conducted to evaluate the effect of NORPLANT use on hemoglobin levels (HB), packed cell volume (PCV) and menstrual bleeding patterns. NORPLANT insertions were performed on 50 healthy volunteers in Ilorin, Nigeria, between January-March 1986. Whole blood samples were collected at admission, 6-month and 12-month follow-up visits, and each acceptor was asked to keep a daily bleeding calendar. Mean age of the acceptors was 32.8 years with a mean parity of 5.3 live births. Almost 50% of the acceptors indicated that they did not want any more children. After 12 month's follow-up, there were a total of three discontinuations, two for excessive menstrual bleeding and one due to husband's objection. Mean HB and PCV values remained relatively unchanged from admission to 12 months. Nearly 50% of the women experienced at least one episode of 8 or more days of continuous bleeding during the first six months of use, and about 20% reported amenorrhea of 90 or more days. Despite the incidence of menstrual bleeding irregularities, acceptability of the NORPLANT method was high as indicated by a 1-year continuation rate of 93.7 per 100 users. Clinically more important was the finding that despite a high proportion of women reporting menstrual pattern changes, HB and PCV levels remained unchanged.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ilorin, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Fakeye
authors.forename: S
authors.initials: S
authors.lastname: Balogh
mesh_terms: D000328:Adult; D001810:Blood Volume / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D016912:Levonorgestrel; D008598:Menstruation / Q000187:drug effects*; D008599:Menstruation Disturbances / Q000139:chemically induced; D009644:Norgestrel / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D009644:Norgestrel; D016912:Levonorgestrel