title: Mutant alleles of the meiotic locus, mei-9, differ in degree of effects on rod chromosome magnification and ring chromosome transmission in Drosophila.
abstract: Two mutant alleles of the meiotic locus, mei-9, have been examined for their effect on magnification of a rod Xbb chromosome and transmission of a ring Xbb chromosome under magnifying conditions. Our results indicate that the effects of these two mutations are allele-specific: mei-9a strongly inhibits both rod chromosome magnification and ring chromosome loss under magnifying conditions, while mei-9b has a smaller inhibitory effect on rod chromosome magnification and on the transmission of ring chromosomes under magnifying conditions. These observations can be explained by a difference in leakiness between the two alleles. Our results demonstrate that mutants defective in excision repair and repair replication inhibit ribosomal gene magnification. This suggests that a component of the excision repair pathway is involved in the process of magnification.
authors.forename: D J
authors.initials: DJ
authors.lastname: Komma
authors.forename: H
authors.initials: H
authors.lastname: Graves
authors.forename: S A
authors.initials: SA
authors.lastname: Endow
mesh_terms: D000483:Alleles; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D008297:Male; D008540:Meiosis; D009154:Mutation; D012303:Ring Chromosomes; D014960:X Chromosome