On the 7-oxo-PGI2 induced late appearing long-lasting cytoprotective effect.
Our results indicate that 7-oxo-PgI2 pretreatment may induce a long lasting cytoprotective effect by preventing ischemia induced intracellular potassium loss and sodium accumulation in myocardial cells of guinea pigs furthermore by protecting from ischemic ultrastructural changes as sarcomere shortening, mitochondrial swelling and irregularity of I, A and Z bands in the rabbit myocardium.
Szekeres
L
L
Institute of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Bálint
Z
Z
Karcsu
S
S
Tósaki
A
A
Udvary
E
E
D000818:Animals; D003327:Coronary Disease / Q000517:prevention & control*; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D006168:Guinea Pigs; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
C033705:7-oxoprostaglandin I2; D012964:Sodium; D011464:Epoprostenol; D011188:Potassium