Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania.
The effects of infection of mice with Leishmania major on liver microsomal protein and cytochrome P-450 were examined. The levels of hepatic microsomal protein and cytochrome P-450 were monitored at 6, 7, 9 and 12 weeks post-infection. The results indicated that the amount of hepatic microsomal protein and cytochrome P-450 were unchanged throughout the course of infection with L. major, despite the high degree of parasite proliferation in Kupffer cells and marked reduction in phagocytosis. The current results clearly indicate that Leishmania-induced macrophage suppression has no inhibitory effect on hepatic microsomal protein and cytochrome P-450.
al-Mofleh
I A
IA
Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
al-Khuwaitir
S A
SA
Mahmoud
A A
AA
Kyegombe
D B
DB
al-Tuwaijri
A S
AS
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007728:Kupffer Cells / Q000276:immunology / Q000469:parasitology; D007895:Leishmania tropica; D007896:Leishmaniasis / Q000276:immunology / Q000378:metabolism*; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D012157:Mononuclear Phagocyte System / Q000000981:diagnostic imaging / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
D011506:Proteins; D013671:Technetium Tc 99m Sulfur Colloid; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases