title: [Hemorrhagic syndrome associated with a factor VIII:C inhibitor in a patient with lymphoma].
abstract: Acquired hemophilia (idiopathic or secondary) is an uncommon clinical condition. A 70-year-old male had a severe hemorrhagic disorder, and an IgG inhibitor of the factor VIII:C was detected in plasma. During the acute phase he was treated with packed red blood cells, frozen fresh plasma and polyvalent immunoglobulins. The hemorrhagic features subsided but the circulating anticoagulant persisted. The administration of an activated prothrombin complex permitted to make the diagnosis of the underlying disease, a highly malignant T type lymphoma. During the treatment with corticosteroids and polychemotherapy the inhibitor activity disappeared.
authors.forename: E
authors.initials: E
authors.lastname: Casas
authors.forename: J
authors.initials: J
authors.lastname: García Puig
authors.forename: A
authors.initials: A
authors.lastname: Villar
authors.forename: A
authors.initials: A
authors.lastname: González Sanz
authors.forename: M E
authors.initials: ME
authors.lastname: Miranda
authors.forename: J
authors.initials: J
authors.lastname: Ortiz Vázquez
mesh_terms: D000368:Aged; D000941:Antigens / Q000037:antagonists & inhibitors*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications*; D008297:Male; D013577:Syndrome
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D005169:Factor VIII
vernacular_title: Síndrome hemorrágico asociado a un inhibidor del factor VIII:C en un paciente con linfoma.