Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor.
Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis. The Drosophila muscarinic receptor contains 788 amino acids with a calculated Mr of 84,807 and displays greater than 60% homology with mammalian muscarinic receptors. The muscarinic receptor maps to the tip of the right arm of the second chromosome of the Drosophila genome.
Onai
T
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Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
FitzGerald
M G
MG
Arakawa
S
S
Gocayne
J D
JD
Urquhart
D A
DA
Hall
L M
LM
Fraser
C M
CM
McCombie
W R
WR
Venter
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011976:Receptors, Muscarinic / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012984:Software
D011976:Receptors, Muscarinic; D004247:DNA