Experimental study on interactions between selenium and tin in mice.
The organ distributions of tin and selenium, and their excretion into urine and feces, were determined in mice. There were four groups; (A) control, (B) Sn (5 mumol/kg/d) ip injection, (C) Se (5 mumol/kg/d) sc injection, and (D) Sn plus Se (5 mumol/kg/d, each). Animals received injections once a day for 12 consecutive days. The results were the following (1) Simultaneous injection of Sn and Se enhanced accumulation of both elements in the body, i.e., in group B, 14.1% of the total injected amount of Sn was excreted into urine and feces; in group C, 46.2% of total injected Se was excreted into urine and feces; in group D, 10.9% of total Sn and 37.5% of total Se were found in excreta. (2) Large amounts of Sn were found in bone, liver, spleen, and kidney in group B. When Se was administered jointly with Sn, the concentrations of Sn in bone and liver were suppressed, whereas those in spleen and pancreas were increased. (3) The effects of Se-injections at this dose on concentrations of Se in organs were small. (4) In plasma, chemical reduction of selenite by stannous chloride was not observed.
Chiba
M
M
Department of Hygiene, Juntendo University School of Medicine, Tokyo, Japan.
Kamiya
N
N
Kikuchi
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005243:Feces / Q000737:chemistry; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D000623:Porphobilinogen Synthase / Q000097:blood; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D014001:Tin / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D017971:Tin Compounds; D014018:Tissue Distribution
D017971:Tin Compounds; C023599:stannous chloride; D014001:Tin; D000623:Porphobilinogen Synthase; D020887:Selenious Acid; D012643:Selenium