Can hemofiltration increase survival time in acute endotoxemia--a porcine shock model.
In a porcine endotoxin shock model employing a continuous intravenous administration of Salmonella abortus equi endotoxin the cardiorespiratory and metabolic parameters were studied with main emphasis on the effect of hemofiltration (HF) as the only therapeutical measurement on the enhancement of survival time. Arachidonic acid (AA) metabolites Thromboxan B2 and 6-Keto-PGF 1-alpha could be lowered significantly by hemofiltration. Measuring the inadequacy of the supply and delivery systems in terms of O2-uptake, CO2 production, lung mechanics, TPR, CO, heart rate and MAP the control group seemed to be more severely compromised than the hemofiltrated groups, although the final outcome as for survival time could not be increased significantly. HF can nonselectively counteract some toxic effects of shock mediators without depriving the organism of beneficial components of a protective system being stimulated at the same time. Once the AA cascade is initiated, pharmacologic inhibition is of limited value as long as a direct specific therapeutic manipulation is still not available. Elimination of mediators by HF helps to combat the overstimulation of host defense mechanisms in ET shock which represents the ultimate threat to the host.
Staubach
K H
KH
Dept. of Surgery, University of Luebeck, W-Germany.
Rau
H G
HG
Kooistra
A
A
Schardey
H M
HM
Hohlbach
G
G
Schilberg
F W
FW
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001794:Blood Pressure; D001834:Body Water / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D002302:Cardiac Output; D004195:Disease Models, Animal; D006339:Heart Rate; D006440:Hemofiltration; D010101:Oxygen Consumption; D011669:Pulmonary Wedge Pressure; D012772:Shock, Septic / Q000503:physiopathology / Q000628:therapy*; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood; D014655:Vascular Resistance
D001095:Arachidonic Acids; D002245:Carbon Dioxide; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha