Coronary artery vasculitis and myocardial infarction associated with antiphospholipid antibodies in a pregnant woman.
A 28-year-old, 16 week primigravida presented with an acute anteroseptal myocardial infarction and a past history of recurrent venous thromboembolism and primary infertility. Although she lacked other clinical features of systemic lupus erythematosus, she had a circulating 'lupus' anticoagulant, anticardiolipin antibodies, a weakly positive anti-nuclear antibody and thrombocytopenia. She died suddenly despite corticosteroid therapy and autopsy revealed coronary arteritis and thrombosis.
Rallings
P
P
Blacktown Hospital, NSW, Australia.
Exner
T
T
Abraham
R
R
D000328:Adult; D001167:Arteritis / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000276:immunology; D002308:Cardiolipins / Q000032:analysis*; D003327:Coronary Disease / Q000276:immunology*; D003328:Coronary Thrombosis / Q000276:immunology* / Q000473:pathology; D003331:Coronary Vessels / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D009203:Myocardial Infarction / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor