[Thyroxine vs iodine and thyroxine. Comparison of the TSH suppression test].
In a crossover study 20 subjects (12 with non-toxic goiter) were given 150 micrograms levo-thyroxine (LT4) or a combination of 100 micrograms LT4 and 100 micrograms iodide daily for 8 weeks. Group I took 150 micrograms LT4 and group II the combination. After 4 weeks the two groups switched medications. A clinical examination, an intravenous TRH test and thyroid sonography were performed before the start of the study and 4 and 8 weeks thereafter. 150 micrograms LT4 daily resulted in significantly higher TSH suppression than the combination. A decrease in thyroid volume from 45 ml (mean range 24-85) to 26 ml (17-70 ml) was registered after as little as 4 weeks' therapy in 12 of 20 subjects with goiter.
Kahaly
G
G
Abteilung Innere Mediźin, Endokrinologie und Stoffwechsel, Klinikum der Johannes-Gutenberg-Universität, Mainz.
Mihaljevic
V
V
Beyer
J
J
Krause
U
U
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006042:Goiter / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use*; D014463:Ultrasonography
D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine
Thyroxin vs Jod und Thyroxin.Vergleich der TSH-suppressiven Wirkung.