Oxygen detoxifying enzymes in parasites: a review.
This review focuses on parasite enzymes which are involved in the detoxification of oxygen radicals, and covers the following enzymes: superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase. These enzymes are crucial for parasites to evade oxygen-mediated attack by host leukocytes, both intracellularly and extracellularly. In addition, the newly defined parasite system involving trypanothione, trypanothione peroxidase and trypanothione reductase is discussed.
Leid
R W
RW
Department of Veterinary Microbiology/Pathology, Washington State University, Pullman 99164-7040.
Suquet
C M
CM
Tanigoshi
L
L
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010271:Parasites / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism
D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D010100:Oxygen