title: Clinical aspects of continuous ambulatory and continuous cyclic peritoneal dialysis in diabetic patients.
abstract: The treatment of end-stage renal diabetic nephropathy remains a challenge. A large experience allows us to clearly outline the advantages and the drawbacks of continuous ambulatory peritoneal dialysis (CAPD) and continuous cyclic peritoneal dialysis (CCPD). Eighty-one patients, mean age 51.3 years, were treated over the last 9 years by CAPD-CCPD. Extrarenal complications, mainly vascular lesions, were present in this high-risk group of patients. The technique was modified in order to inject intraperitoneally, 4 times per day, insulin to control blood glucose level in CAPD patients. Actuarial survival was 92% at 1 year, 50% at 4 years mainly influenced by age: 85% survival at 2 years in 35 patients aged less than 50 years old and 62% at 2 years in 46 patients aged more than 50 years old. The main causes of death were of cardiovascular origin: myocardial infarction, stroke, atherosclerotic vasculopathy. The main causes of transfer to hemodialysis were due to technical complications. Peritonitis rate was one episode every 14 patient-months. Control of blood pressure, blood glucose levels, main biological parameters, and visual status were the clear advantages of the method. Peripheral vascular disease is not influenced by the technique. CAPD-CCPD is the technique of first choice in young diabetics and the preferential technique for home dialysis.
authors.affiliation: Department of Nephrology, Groupe Hospitalier Pitié-Salpétrière, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Rottembourg
authors.forename: B
authors.initials: B
authors.lastname: Issad
authors.forename: M
authors.initials: M
authors.lastname: Allouache
authors.forename: A
authors.initials: A
authors.lastname: Baumelou
authors.forename: G
authors.initials: G
authors.lastname: Deray
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
mesh_terms: D000206:Actuarial Analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003928:Diabetic Nephropathies / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012307:Risk Factors