Similarities between the stimulus properties of phenylpropanolamine and amphetamine.
Rats at 80% body weight were trained to discriminate 1.0 mg/kg d-amphetamine versus saline in a two-lever, discrete trial drug discrimination task to obtain food pellets. After reliable discriminative control of lever choice was established, various doses of d,l-phenylpropanolamine (PPA, i.e., d,l-norephedrine) were substituted for the amphetamine training dose in non-reinforced test trials. Test doses of 10, 20, and 40 mg/kg PPA resulted in over 90% responses on the amphetamine-appropriate lever. Lower doses (1.25, 2.5, and 5.0 mg/kg) resulted in predominantly saline-appropriate responses. The generalization seen after the 20 mg/kg dose of phenylpropanolamine was blocked by pretreatment with 0.5 mg/kg haloperidol, suggesting that the generalization from amphetamine to PPA was mediated by a dopaminergic mechanism.
Lee
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F
Department of Psychology, Princeton University, NJ 08544.
Stafford
I
I
Hoebel
B G
BG
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D005260:Female; D005795:Generalization, Stimulus / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D010665:Phenylpropanolamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010665:Phenylpropanolamine; D000661:Amphetamine; D006220:Haloperidol