[Effect of the lethal Bacillus anthracis toxin on phagocytosis and the dynamics of the change in the enzyme activity of the antioxidative system of peritoneal mononuclear phagocytes in mice with differing hereditary immunity to anthrax].
It was demonstrated, that the lethal in vitro suppressed the phagocytic activity of peritoneal mononuclear phagocyte (Mph) and enhanced the level activity of glutathione peroxidase to H2O2 (GP-H2O2) in Mph of resistant to anthrax BALB mice. In Mph BALB the authors observed dependent-dose enhancement of GP-H2O2 activity and reduction of the ratio of level glutathione reductase (GR) to GP-H2O2 (GR/GP-H2O2). The enhancement of activity GR-H2O2 in Mph CBA was not dependent on the doses of toxin. The coefficient GR/GP-H2O2 was similar to the control. The mechanisms of hereditary resistance to anthrax were discussed.
Abalakin
V A
VA
Sorochinskaia
E P
EP
Osipova
N I
NI
Iurkiv
V A
VA
D000818:Animals; D000881:Anthrax / Q000201:enzymology / Q000276:immunology*; D000942:Antigens, Bacterial; D000975:Antioxidants; D001408:Bacillus anthracis; D001427:Bacterial Toxins / Q000302:isolation & purification / Q000633:toxicity*; D002478:Cells, Cultured; D004198:Disease Susceptibility; D007111:Immunity, Cellular / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010529:Peritoneal Cavity / Q000166:cytology; D010586:Phagocytes / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*
D000942:Antigens, Bacterial; D000975:Antioxidants; D001427:Bacterial Toxins; C030325:anthrax toxin
Vliianie letal'nogo toksina Bacillus anthracis na fagotsitoz i dinamiku izmeneniia aktivnosti fermentov antiokislitel'noĭ sistemy peritoneal'nykh mononuklearnykh fagotsitov mysheĭ s razlichnym nasledstvennym immunitetom k sibirskoĭ iazve.