title: [Comparative assessment of the effect of nitroglycerin, sodium nitroprusside and isoket on hemodynamics in patients with ischemic heart disease].
abstract: The effects of glycerol trinitrate (GTN), sodium nitroprusside and isoket on central hemodynamics, myocardial contractility and myocardial function have been compared. 65 patients with ischemic heart disease have been examined. All the patients were divided into 3 groups depending on the drug studied. GTN was administered sublingually at a dose of 0.5 mg, while sodium nitroprusside and isoket were infused at doses of 1.5 micrograms (kg min) and 400 micrograms/min, respectively. It has been shown that GTN and isoket effects on central hemodynamics were mainly mediated by their venodilating action and preload reduction, thus promoting to the improvement of the myocardial function. Hemodynamic effects of sodium nitroprusside on the cardiovascular system are mediated by its dilating action on the arterial bed and afterload reduction.
authors.forename: A A
authors.initials: AA
authors.lastname: Buniatian
authors.forename: A G
authors.initials: AG
authors.lastname: Iavorovskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Flerov
authors.forename: A M
authors.initials: AM
authors.lastname: Abugov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Krasin
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D005292:Ferricyanides / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000627:therapeutic use*; D009599:Nitroprusside / Q000627:therapeutic use*
chemical_list: D005292:Ferricyanides; D009599:Nitroprusside; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
vernacular_title: Sravnitel'naia otsenka deĭstviia na gemodinamiku nitroglitserina, nitroprussida natriia i izoketa u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.