title: Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.
abstract: LY134046, a potent, selective inhibitor of rat brain phenylethanolamine N-methyltransferase, was shown to increase activity in 18- and 19-day-old rats. The effects on day 25 were different, with LY134046 causing a decrease in activity. The effects of yohimbine, a selective antagonist of the alpha-2 adrenergic receptor, were markedly different from LY134046, causing a decrease in activity on day 19. These data suggest that epinephrine synthesis may play an inhibitory role in the regulation of activity in young rats.
authors.affiliation: Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: I N
authors.initials: IN
authors.lastname: Mefford
authors.forename: A L
authors.initials: AL
authors.lastname: Lawrenz
authors.forename: J K
authors.initials: JK
authors.lastname: Hsiao
authors.forename: J N
authors.initials: JN
authors.lastname: Crawley
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010625:Phenylethanolamine N-Methyltransferase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D015016:Yohimbine; C028625:LY 134046; D010625:Phenylethanolamine N-Methyltransferase