title: Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse.
abstract: The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the same strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.
authors.affiliation: Istituto di Psicobiologia e Psicofarmacologia (C.N.R.), Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cabib
authors.forename: S
authors.initials: S
authors.lastname: Puglisi-Allegra
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004873:Ergolines / Q000494:pharmacology*; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects; D019257:Quinpirole; D012919:Social Behavior; D013045:Species Specificity; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D004873:Ergolines; D019257:Quinpirole