title: [Recovery of impaired respiratory activity in cats by thyroliberin analog (PR-546) devoid of hormonal properties].
abstract: Synthetic analogue thyroliberin (PR-546) devoid of hormonal activity, recovered respiration in conditions of hyperventilation, two-sided vagotomy and hypoxia, caused by the 40-70% bleeding. PR-546 (in doses 100-500 micrograms/kg) intravenously injected was shown to abolish diagram activity decreased effect after hyperventilation. Injection of PR-546 to vagotomized cats in 1.5-2 h, increased breathing rate. The breathing activity resumed after long breaks in respiration as a result of peptide injection. The responses to analogue introductions is similar to the thyroliberin effect.
authors.forename: I E
authors.initials: IE
authors.lastname: Gurskaia
authors.forename: Ts V
authors.initials: TsV
authors.lastname: Serbeniuk
authors.forename: A D
authors.initials: AD
authors.lastname: Sliuta
authors.forename: P Ia
authors.initials: PIa
authors.lastname: Romanovskiĭ
mesh_terms: D000818:Animals; D002415:Cats; D006985:Hyperventilation / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000031:analogs & derivatives; D014628:Vagotomy
chemical_list: C060662:PR 546; D013973:Thyrotropin-Releasing Hormone
vernacular_title: Vosstanovlenie narushennoĭ dykhatel'noĭ aktivnosti koshek analogom tiroliberina (PR-546), lishennym gormonal'nykh svoĭstv.