title: Alfentanil requirement in Crohn's disease. Increased alfentanil dose requirement in patients with Crohn's disease.
abstract: The dose requirement of alfentanil as a supplement to nitrous oxide anaesthesia was studied in 13 patients with Crohn's disease and seven control patients all of whom underwent laparotomy. Alfentanil was administered as a variable rate infusion with supplemental bolus injections titrated to the patient's needs. The alfentanil requirement was independent of the duration of surgery and was significantly higher in patients with Crohn's disease than in control patients. The results indicate that Crohn's disease alters the dose requirement of alfentanil.
authors.affiliation: Department of Anaesthesiology, University Hospital Leiden, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Gesink-van der Veer
authors.forename: A G
authors.initials: AG
authors.lastname: Burm
authors.forename: P J
authors.initials: PJ
authors.lastname: Hennis
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D015760:Alfentanil; D000769:Anesthesia, Inhalation; D003424:Crohn Disease / Q000097:blood / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D009961:Orosomucoid / Q000032:analysis
chemical_list: D000759:Adjuvants, Anesthesia; D009961:Orosomucoid; D015760:Alfentanil; D009609:Nitrous Oxide; D005283:Fentanyl