[The influence of GABA injected into cerebral ventricle on electrical activities of pain-excitation neurons and pain-inhibition neurons in nucleus parafascicularis of the thalamus of rats].
The influence of intraventricular injection of GABA on electrical activities of PEN and PIN in nucleus parafascicularis of the thalamus of rats was studied. The results showed that GABA could significantly inhibit the electrical discharges of PEN and increase the electrical discharges of PIN. So it was believed that intraventricularly injected GABA could antagonize or partly antagonize the excitatory action of noxious stimuli and might thus produce analgesia.
Li
Y R
YR
Yang
Y Z
YZ
Sun
M Z
MZ
D000818:Animals; D004594:Electrophysiology; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000187:drug effects; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid