[Acute dyspnea following intravenous administration of vinblastine/mitomycin C].
A 49 year old woman treated for metastatic adenocarcinoma of the breast suddenly developed the symptoms of acute pulmonary edema 90 minutes after infusion of mitomycin C/vinblastine. No other causes of dyspnea were found. This dangerous side effect of mitomycin C/vinblastine therapy has been described previously. The appearance of dyspnea after the injection of vinblastine in patients treated with the above-mentioned drug combination should always be considered an alarming symptom.
Lagler
U
U
Med. Abteilung, Spital Pflegerinnenschule Zürich.
Gattiker
H H
HH
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms; D004417:Dyspnea / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000150:complications; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects*
D008937:Mitomycins; D016685:Mitomycin; D014747:Vinblastine
Akute Dyspnoe nach intravenöser Gabe von Vinblastin/Mitomycin C.