title: Human monocytes can produce tissue-type plasminogen activator.
abstract: Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.
authors.affiliation: Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia.
authors.forename: P H
authors.initials: PH
authors.lastname: Hart
authors.forename: G F
authors.initials: GF
authors.lastname: Vitti
authors.forename: D R
authors.initials: DR
authors.lastname: Burgess
authors.forename: D K
authors.initials: DK
authors.lastname: Singleton
authors.forename: J A
authors.initials: JA
authors.lastname: Hamilton
mesh_terms: D001681:Biological Assay; D015152:Blotting, Northern; D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D009000:Monocytes / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D010959:Tissue Plasminogen Activator