title: Gadolinium-DTPA-enhanced magnetic resonance imaging in intractable partial epilepsy.
abstract: We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26% the unenhanced image was positive, and the abnormality enhanced with Gd-DTPA. In 13% the unenhanced MR image was positive, but the abnormality did not enhance with Gd-DTPA. Gd-DTPA does not appear to increase the diagnostic yield of MRI in the presurgical evaluation of patients with partial epilepsy if the unenhanced MRIs are normal.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905.
authors.forename: G D
authors.initials: GD
authors.lastname: Cascino
authors.forename: K A
authors.initials: KA
authors.lastname: Hirschorn
authors.forename: C R
authors.initials: CR
authors.lastname: Jack
authors.forename: F W
authors.initials: FW
authors.lastname: Sharbrough
mesh_terms: D000293:Adolescent; D000328:Adult; D003287:Contrast Media; D004828:Epilepsies, Partial / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA