Isodicentric X chromosome in myeloproliferative disorders.
Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
Temperani
P
P
Second Medical Clinic, University of Modena, Italy.
Zucchini
P
P
Emilia
G
G
Sacchi
S
S
Selleri
L
L
Torelli
U
U
D000368:Aged; D002871:Chromosome Banding; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D055728:Primary Myelofibrosis / Q000235:genetics / Q000473:pathology; D012729:Sex Chromosome Aberrations / Q000235:genetics / Q000473:pathology; D014960:X Chromosome / Q000648:ultrastructure*
D004273:DNA, Neoplasm; D004247:DNA