Aluminum in parenteral products: analysis, reduction, and implications for pediatric TPN.
Performance and cost of the best available analytical methodology for the measurement of aluminum in parenteral products are presented. Typical levels of aluminum in representative solutions are summarized. A methodical approach to the minimization of aluminum contamination in the manufacturing process is considered in light of aqueous aluminum chemical considerations. Results of long-term clinical follow-up studies of infants maintained on currently manufactured TPN solutions indicate no adverse pathology arising from aluminum.
Rabinow
B E
BE
Ericson
S
S
Shelborne
T
T
D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000009:adverse effects / Q000032:analysis*; D001847:Bone Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D004340:Drug Contamination / Q000032:analysis / Q000517:prevention & control; D006801:Humans; D007223:Infant; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012996:Solutions / Q000032:analysis / Q000592:standards
D012996:Solutions; D000535:Aluminum