[Prevention of noise-induced hearing loss].
Noise-induced hearing loss appears to result from energy depletion in the hair cells. Cell membrane permeability is increased in hypomagnesemia, causing Na+ and Ca++ influx, with subsequent increase in energy-dependent ion-pumping. Energy exhaustion is further enhanced by hypomagnesemia-induced vasoconstriction. Dietary supplementation with magnesium was shown to lessen hearing loss in noise-exposed rats. It is postulated that the same mechanisms may act in man and the possible benefit of magnesium supplementation for noise-exposed workers should be investigated.
Joachims
H Z
HZ
Otolaryngology Dept., Rambam Medical Center, Haifa.
Ising
H
H
Gunther
T
T
D000818:Animals; D006198:Hair Cells, Auditory / Q000378:metabolism; D006317:Hearing Loss, Noise-Induced / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000150:complications / Q000378:metabolism; D009784:Occupational Diseases / Q000517:prevention & control; D051381:Rats
D008274:Magnesium