Evaluation of Livingston's chemotherapy combined with immunotherapy in treatment of small cell lung carcinoma.
The comparative studies presented in this work aimed at evaluation of isoprinosine in the combined cytostatic and irradiation treatment of small cell lung cancer. The comparison was performed between three groups of patients: 1. treated by the method of Livingston et al., 2. treated by the method of Livingston et al. in a combination with isoprinosine, 3. treated by the same method but the cycle of treatment was shortened from 3 weeks to 8 days with the parallel application of isoprinosine as immunotherapeutic and stimulator of the hematopoietic system. It was found that the mean time of complete and partial remission and the mean survival time was longer in the second and third group of patients. The mean survival time in the first group amounted to 3 weeks, in the second to 43 weeks and in the third to 49 weeks. It was also shown that post-chemotherapy complications were less frequent and less intensive.
Szklarz
E
E
Department of Lung Diseases, Clinical Military Hospital, Wrocław.
Jaszczołt
M
M
Woźnicki
Z
Z
Głuszczyk-Ferenc
B
B
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007542:Inosine Pranobex / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D007542:Inosine Pranobex