title: The detection of an antibody against IgA allotype A2M 2 and a study of the Am genetic marker among the Han Chinese population.
abstract: The serum of a woman was found by the Ouchterlony double-diffusion and the hemagglutination inhibition (HAI) methods to have immunoglobulin A (IgA) deficiency. Further investigation using the hemagglutination (HA) test with red cells coated with IgA myeloma proteins of different specificities showed that the serum agglutinated only IgA2-, A2M-1, and A2M 2-coated cells. The patterns of the HAI test with a reference panel confirmed the presence of two specificities. One was anti-IgA2 and the other was a rare antibody against the allotype A2M 2. The anti-A2M 2 was used for population studies. Testing of the Han Chinese population, including family studies, confirms that A2M.1 and A2M.2 have an autosomal dominant mode of inheritance and are controlled by a codominant allele. The distribution of the two Am genetic markers among the Han Chinese population demonstrated A2M.1 with a gene frequency of 0.553 and A2M.2 with a gene frequency of 0.447 (chi 2 = 0.145, 0.80 greater than p greater than 0.70).
authors.affiliation: Blood Group Reference Laboratory of Shanghai Red Cross Blood Center, People's Republic of China.
authors.forename: G
authors.initials: G
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Fang
authors.forename: W
authors.initials: W
authors.lastname: Hu
authors.forename: H
authors.initials: H
authors.lastname: Jia
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Fukada
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: H
authors.initials: H
authors.lastname: Saji
authors.forename: T D
authors.initials: TD
authors.lastname: Lee
mesh_terms: D000483:Alleles; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000918:Antibody Specificity; D002681:China; D005190:Family; D005819:Genetic Markers; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D005819:Genetic Markers; D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; C049937:anti-IgA