title: [A case of Guillain-Barré syndrome treated with intravenous high doses of immunoglobulins].
abstract: A case of severe Guillain-Barré syndrome unresponsive to plasma exchange was treated with high-dose intravenous immunoglobulins. The same therapy has been already successfully used in cases of chronic polyneuropathy. Immunoglobulin administration was scheduled as follows: a pulse dose (400 mg/kg/day) for three consecutive days, followed by maintenance dose (400 mg/kg every 15 days) until achievement of sustained clinical improvement. We observed a time-related response between immunoglobulin administration and clinical improvement. To our knowledge this is the first case of Guillain-Barré syndrome treated with high-dose intravenous immunoglobulins. Further studies are obviously necessary to confirm the effectiveness of this treatment in Guillain-Barré syndrome.
authors.affiliation: Divisione Neurologica, Ospedale Civile, Pordenone, Italie.
authors.forename: G
authors.initials: G
authors.lastname: Mauro
mesh_terms: D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000188:drug therapy*
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
vernacular_title: Un cas de syndrome de Guillain-Barré traité par fortes doses d'immunoglobulines par voie intraveineuse.