[Prostacyclin-thromboxane balance and risk factors of ischemic heart disease].
The paper considers the significance of prostacyclin-thromboxane (PGI2/TxA2) balance for cardiovascular performance in health and in angina pectoris and myocardial infarction. The functional interaction between prostacyclin and thromboxane was examined in terms of a number of risk factors for coronary heart disease (CHD), such as ageing, atherosclerosis, arterial hypertension, diabetes mellitus, obesity, hypokinesia, smoking, alcoholism, sex differences, and predisposition to the disease. A unidirectional pattern of changes in the PGI2/TxA2 balance towards TxA2 was found in CHD and in the presence of all the aforementioned risk factors. The paper discusses possible mechanisms responsible for these changes, as well as their contribution to the pathogenesis and prevention of CHD.
Markov
Kh M
KhM
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications* / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology*; D011464:Epoprostenol / Q000096:biosynthesis / Q000172:deficiency*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism; D013928:Thromboxane A2 / Q000097:blood*
D013928:Thromboxane A2; D011464:Epoprostenol
Prostatsiklin-tromboksanovyĭ balans i faktory riska ishemicheskoĭ bolezni serdtsa.