title: Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.
abstract: In 6 growth hormone-deficient children, we have demonstrated that 3-N-demethylation of caffeine as measured by the 13CO2 caffeine breath test is decreased following 1 month of growth hormone therapy (8.4 +/- 1.0 vs. 6.8 +/- 1.2% 13C/2 h after treatment). These findings could be of clinical importance. The initiation of growth hormone therapy in growth hormone-deficient children could alter the clearance of drugs metabolized through the mixed-function oxidase pathway given for concurrent conditions, and necessitate adjustment of the therapeutic regimen.
authors.affiliation: Department of Pediatrics, Michael Reese Medical Center, Ill.
authors.forename: L L
authors.initials: LL
authors.lastname: Levitsky
authors.forename: D A
authors.initials: DA
authors.lastname: Schoeller
authors.forename: G H
authors.initials: GH
authors.lastname: Lambert
authors.forename: D V
authors.initials: DV
authors.lastname: Edidin
mesh_terms: D001944:Breath Tests; D002110:Caffeine / Q000378:metabolism*; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes; D002648:Child; D002675:Child, Preschool; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003640:Dealkylation; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism
chemical_list: D002247:Carbon Isotopes; D002245:Carbon Dioxide; D002110:Caffeine; D013006:Growth Hormone; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases