title: Prediction of changing cerebral blood flow by use of the conjunctival oxygen tension/arterial oxygen tension index.
abstract: Current methods of assessing cerebral blood flow (CBF) are limited in their ability to provide data at the bedside in a timely, inexpensive, and continuous fashion. Since the palpebral conjunctiva is perfused by branches of the internal carotid artery, perfusion of this tissue may reflect global CBF. Conjunctival oxygen tension (PcjO2), PaO2, PaCO2, and pH were measured in ten healthy subjects during normal ventilation and active hyperventilation. CBF was measured simultaneously using positron emission tomography. CBF decreased from an average of 64.3 +/- 15.1 ml x 100 g-1 x min-1 during baseline measurements to 33.2 +/- 8.4 ml x 100 g-1 x min-1 during hyperventilation. The ratio of PcjO2 to PaO2 (the PcjO2/PaO2 index) decreased from 0.53 +/- 0.07 to 0.35 +/- 0.09 in the same time period. The PcjO2/PaO2 index was significantly correlated with CBF (r = .78, p less than .001). We conclude that the PcjO2/PaO2 index may reflect the reduction in CBF induced by hyperventilation in normal humans, and should be investigated further as a method of assessing CBF in other settings which can result in globally reduced cerebral perfusion.
authors.affiliation: Department of Internal Medicine, Case Western Reserve University, Cleveland, OH.
authors.forename: W F
authors.initials: WF
authors.lastname: Rutherford
authors.forename: E A
authors.initials: EA
authors.lastname: Panacek
authors.forename: J K
authors.initials: JK
authors.lastname: Griffith
authors.forename: J A
authors.initials: JA
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Munger
authors.forename: E
authors.initials: E
authors.lastname: Bednarczyk
authors.forename: F
authors.initials: F
authors.lastname: Miraldi
authors.forename: C J
authors.initials: CJ
authors.lastname: Fisher
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation; D003228:Conjunctiva / Q000098:blood supply*; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D014055:Tomography, Emission-Computed
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen