Living-related donor kidney transplants.
1. Black kidney graft recipients do poorly when compared to Caucasians and Asians. This effect is significant for both Black 2-haplotype identical and 1-haplotype identical sibling transplants. Since 1984 graft survival in Caucasian siblings was 90% at 3 years for 2-haplotype matches and 80% at 3 years for 1-haplotype matches. 2. CsA has had a 10% effect in 1-haplotype sibling transplants comparing the results from 1984 through 1989 to 1978 through 1983. The CsA effect is about a 5% difference in HLA-identical transplants. 3. Diabetic patients transplanted after 1984 had a significantly poor graft survival which was ameliorated when treatment was equivalent to ESRD patients with glomerulonephritis and pyelonephritis use of CsA in more recent times. 4. The transfusion effect was significant in 2-haplotype and 1-haplotype transplants in the 1978 to 1983 period and is now not significant in any LRD transplant categories. 5. HLA panel-reactive antibody did not effect graft survival of LRD transplants. 6. CsA has a significant effect on 1-haplotype transplants but no effect on 2-haplotype transplants.
Hardy
S
S
Cicciarelli
J
J
D001803:Blood Transfusion; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens; D006239:Haplotypes; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000706:statistics & numerical data / Q000639:trends; D008297:Male; D044469:Racial Groups; D012042:Registries; D014019:Tissue Donors
D003524:Cyclosporins; D006680:HLA Antigens