title: [Spontaneous post-partum inhibitor to factor VIII clotting anti- gen--a cause of life-threatening hemorrhage].
abstract: Pathologic inhibitors of blood coagulation as cause of acquired haemostatic failure are rare. We report about a 23 years old primigravida with a life-threatening haemorrhage post partum. Analysis of coagulation parameters showed the presence of inhibitor to factor VIII. We reacted successfully with cyclophosphamid and cryoprecipitated factor VIII. References to diagnostic and therapy of pathologic clotting factor inhibitors are described.
authors.affiliation: Institut für Klinische Chemie und Laboratoriumsdiagnostik, Medizinischen Akademie Magdeburg.
authors.forename: G
authors.initials: G
authors.lastname: Lutze
authors.forename: E
authors.initials: E
authors.lastname: Canzler
authors.forename: H J
authors.initials: HJ
authors.lastname: Presser
mesh_terms: D000328:Adult; D000941:Antigens / Q000172:deficiency* / Q000378:metabolism*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology* / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use; D005353:Fibronectins / Q000627:therapeutic use; D005500:Follow-Up Studies; D006467:Hemophilia A; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014842:von Willebrand Diseases
chemical_list: D000941:Antigens; D005353:Fibronectins; C026912:cryoprecipitate coagulum; D003520:Cyclophosphamide; D005169:Factor VIII; D005340:Fibrinogen
vernacular_title: Spontaner Gerinnungsfaktor-VIII: C-Inhibitor post partum--Ursache lebensbedrohlicher Blutung.