Coumamidines, new broad spectrum antibiotics of the cinodine type. II. Isolation and structural elucidation.
Two novel, isomeric compounds, coumamidines gamma 1 and gamma 2, were isolated from fermentations of an actinomycete. The structures were elucidated spectroscopically using 2D NMR correlation experiments and mass spectral data. The coumamidines were found to be close structural relatives of the cinodines (LL-BM123 gamma 1 and gamma 2).
Chen
R H
RH
Anti-infective Research, Abbott Laboratories, Abbott Park, Illinois 60064.
Whittern
D N
DN
Buko
A M
AM
McAlpine
J B
JB
D000192:Actinomycetales / Q000378:metabolism*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D002850:Chromatography, Gel; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C059944:coumamidine gamma2; C059942:coumamidine gamma1