Chromosomal hypersensitivity in mutant MCN-151 mouse cells exposed to mitomycin C.
After exposure to mitomycin C, the mouse lymphoma cell mutant MCN-151, previously shown to be sensitive to the toxic effect of the drug, demonstrates higher frequencies of chromatid-type aberrations and of aberrant cells in comparison to L5178Y cells. At any given dose of mitomycin C, the frequencies of chromosomal aberrations increased with time reaching a plateau in both cell strains, with the mutant in all cases being more sensitive than normal cells.
Rosselli
F
F
Institut Curie, Section de Biologie, Paris, France.
Moustacchi
E
E
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D005816:Genetic Complementation Test; D066298:In Vitro Techniques; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity*
D008937:Mitomycins; D016685:Mitomycin