Expression of the recE gene during induction of the SOS response in Bacillus subtilis recombination-deficient strains.
A transcriptional fusion of the recE gene to a reporter gene has been constructed. Expression of recE was found to be induced upon damage to DNA with either mitomycin C or nalidixic acid. This specific transcriptional induction is blocked by a recE mutation. Mutations affecting the recB, recF and recL gene products markedly reduced induction. However, derepression of recE seems to be independent of the ATP-dependent DNase activity of the exonuclease V enzyme (also called AddAB enzyme).
Gassel
M
M
Max-Planck-Institut für Molekulare Genetik, Berlin, FRG.
Alonso
J C
JC
D001412:Bacillus subtilis / Q000201:enzymology* / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D029968:Escherichia coli Proteins; D005090:Exodeoxyribonucleases / Q000096:biosynthesis* / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology; D010957:Plasmids; D011993:Recombinant Fusion Proteins / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D013014:SOS Response, Genetics / Q000502:physiology*
D029968:Escherichia coli Proteins; D008937:Mitomycins; D011993:Recombinant Fusion Proteins; D009268:Nalidixic Acid; D016685:Mitomycin; D005090:Exodeoxyribonucleases; C038225:recE protein, E coli