1-5-Hydroxytryptophan-induced flat body posture in the rat: antagonism by ritanserin and potentiation after 5,7-dihydroxytryptamine.
1-5-Hydroxytryptophan (1-5-HTP)-induced flat body posture (FBP) was antagonized by ritanserin in doses that were lower than those needed to antagonize head-twitches (HTW) and forepaw treading (FPT). 5,7-Dihydroxytryptamine (5,7-DHT) potentiated 1-5-HTP-induced FBP but not HTW or FPT. Ritanserin interacted with 5-HT2 and 5-HT1c receptors. 1-5-HTP-induced FBP could be mediated by postsynaptic 5-HT1c receptors and could serve as a behavioral model of postsynaptic 5-HT1c receptor stimulation in the CNS.
Colpaert
F C
FC
Neurobiology Division, Fondax, Groupe de Recherche Servier, Puteaux, France.
Koek
W
W
Lategan
A
A
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004357:Drug Synergism; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology*; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D016713:Ritanserin
D004102:Dihydroxytryptamines; D010880:Piperidines; D016713:Ritanserin; D015116:5,7-Dihydroxytryptamine; D006916:5-Hydroxytryptophan