Thirteenfold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with nifurtimox.
Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. The mean incidence of chromosomal aberrations increased from control values of 1.75 +/- 1.39 (8 patients) to 23.55 +/- 9.55 (6 patients) at a significance of P less than 0.0001. G-banding analysis of chromosomal aberration sites revealed that treated patients present coincidence in the chromosome regions affected: 1p11, 1q11-12, 9q11-13, 17q11-21, 2p21, 2q23, 2q31, 2q33, 6p21, 6p21, 7q32, 13q14, 13q22, 15q22. These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment.
Gorla
N B
NB
Sección Citogenética, Academia Nacional de Medicina, Buenos Aires, Argentina.
Ledesma
O S
OS
Barbieri
G P
GP
Larripa
I B
IB
D000293:Adolescent; D014355:Chagas Disease / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009547:Nifurtimox / Q000627:therapeutic use / Q000633:toxicity*; D009581:Nitrofurans / Q000633:toxicity*
D009581:Nitrofurans; D009547:Nifurtimox