[Induction of unstable mutations in Drosophila melanogaster by microinjections of DNA from oncogene viruses into the embryonic polar plasm. Part IV. Malignantization of tissues of mutant larvae].
We have demonstrated that larval tissues of mutant stocks induced by injections of oncogene virus DNA (Sa7 and RSV) show the neoplastic mode of growth after transplantation into the body cavity of wild-type flies. Neoplasms tested were shown to be ordinary benign insect neoplasms, and at the same time they show the dominant mode of heredity typical of the neoplasms of vertebrates. Genetic factors responsible for the neoplastic growth are localised in the 3rd chromosome in the stocks obtained after injections of the adenoviral Sa7 DNA, and in the 2nd and 3rd chromosomes in the mutant stocks induced by the retroviral DNA.
Nabirochkin
S D
SD
Nabirochkina
E N
EN
Gazarian
K G
KG
D000818:Animals; D004279:DNA, Viral / Q000235:genetics*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D007814:Larva / Q000235:genetics*; D008845:Microinjections; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D009858:Oncogenic Viruses / Q000235:genetics*
D004279:DNA, Viral
Induktsiia nestabil'nykh mutatsiĭ u Drosophila melanogaster mikroin''ektsieĭ DNK onkogennykh virusov v poliarnuiu plazmu émbrionov. Soobshcheniie IV. Malignizatsiia tkaneĭ mutantnykh lichinok.