title: [In vitro susceptibility of a strain of Rickettsia recently isolated from a case of Japanese spotted fever to chemotherapeutic agents].
abstract: The in vitro susceptibilities to five chemotherapeutic agents against a rickettsial strain which was isolated from a case of Japanese spotted fever were determined by cell culture system. Minocycline was the most effective (MIC, 0.15 micrograms/ml) followed by Tetracycline and Demethylchlor tetracycline (0.31 micrograms/ml 0.16 micrograms/ml). Chloramphenicol was less effective (5 micrograms/ml) and Aminobenzyl-penicillin was not effective with the MIC of 10 micrograms/ml or less. Thus, the earlier administration of Minocycline is recommended to clinically suspicious cases of Japanese spotted fever as well as Tsutsugamushi disease.
authors.forename: T
authors.initials: T
authors.lastname: Suto
authors.forename: H
authors.initials: H
authors.lastname: Hatakeyama
authors.forename: R
authors.initials: R
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: F
authors.initials: F
authors.lastname: Mahara
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D012281:Rickettsia / Q000187:drug effects* / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents