title: [Chemoprophylaxis of superficial tumors of the bladder with thiotepa: long-term results].
abstract: A retrospective study was done on the long-term evolution of 48 patients diagnosed of transitional cell carcinoma of the bladder who were treated with full transurethral resection and intracavitary chemoprophylaxis with Thiotepa. All patients presented a minimum disease control period of 36 months, and were followed for 85.3 months on the average (38-156) months. The actuarial study of the relapse-free intervals turned out into a possibility of 89.3% of patients without a relapse by 5 years, and of 64.6% by 10 years. The actuarial study of tumor progress showed that 91.4% and 58.8% of the patients were free of progression by 5 and 10 years respectively. pT1-G3 tumors did not show greater relapse rate nor progression than the rest of cases, it is therefore convenient to consider other prognostic factors in the long-term evolution of these patients. 85.7% of patient deaths were due to direct consequence of the bladder tumor. These results and their clinical implications are analyzed.
authors.forename: R
authors.initials: R
authors.lastname: Durán
authors.forename: G R
authors.initials: GR
authors.lastname: Reina
authors.forename: J M
authors.initials: JM
authors.lastname: Hontoria
authors.forename: C
authors.initials: C
authors.lastname: Merino
authors.forename: C
authors.initials: C
authors.lastname: Olivier
authors.forename: J
authors.initials: J
authors.lastname: Carballido
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D012189:Retrospective Studies; D013852:Thiotepa / Q000008:administration & dosage / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000517:prevention & control*
chemical_list: D013852:Thiotepa
vernacular_title: Quimioprofilaxis de los tumores vesicales superficiales con thiotepa: resultados a largo plazo.