[Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract].
A morphological classification indicating the stage of the prevention of aldose reductase inhibitor (ARI) on the rat galactosemic cataract was investigated. Three week old rats (body weight 50 g) were fed with a 25% galactose diet. Two kinds of ARIs (ADN-138, FR-74366) were used with a different dose 25% galactose fed each drug. The rats on the 25% galactose diet rapidly developed cataracts in the equatorial region of the lens followed by total cataracts. The morphological processes of the galactose cataracts receiving preventive treatment of ARI were divided into 5 types according to their intensity.
Akagi
Y
Y
Ikebe
H
H
Terubayashi
H
H
Takahashi
Y
Y
Tsuji
T
T
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D005693:Galactosemias / Q000150:complications* / Q000517:prevention & control; D010078:Oxazines / Q000627:therapeutic use; D010793:Phthalazines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D010078:Oxazines; D010793:Phthalazines; D011758:Pyrroles; C042829:ponalrestat; C054644:ADN 138; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase