title: Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1.
abstract: Neopterin, a biochemical marker for the activation of cell-mediated immune reactions, was determined in serum and cerebrospinal fluid (CSF) from patients infected with HIV-1. A significant correlation was found between serum and CSF neopterin concentrations, although concentrations of neopterin in serum were more closely correlated with the clinical severity of HIV-1 infection than those in CSF. However, higher CSF levels were observed in patients with neurologic/psychiatric symptoms than in unaffected patients. Also, quotients of CSF neopterin versus serum neopterin concentrations were increased, indicating intrathecal production of neopterin. Positive HIV-1 isolation from peripheral blood mononuclear cells (PBMC) was associated with higher neopterin concentrations in serum, when compared with negative HIV-1 isolation. Neopterin in CSF appears to be a suitable biochemical marker in patients with HIV-1 infection for detecting overt neurologic/psychiatric disturbances. The data suggest that in HIV-1 infected patients, cell-mediated immune reactions might be activated intrathecally and might contribute to neuropsychiatric disease.
authors.affiliation: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: F
authors.initials: F
authors.lastname: Chiodi
authors.forename: J
authors.initials: J
authors.lastname: Albert
authors.forename: B
authors.initials: B
authors.lastname: Asjö
authors.forename: L
authors.initials: L
authors.lastname: Hagberg
authors.forename: A
authors.initials: A
authors.lastname: Hausen
authors.forename: G
authors.initials: G
authors.lastname: Norkrans
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: E R
authors.initials: ER
authors.lastname: Werner
authors.forename: H
authors.initials: H
authors.lastname: Wachter
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D000328:Adult; D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology
chemical_list: D001708:Biopterins; D019798:Neopterin