title: [Atrial flutter with 1:1 AV conduction during intravenous flecainide treatment].
abstract: Acute drug treatment of recent onset atrial flutter may reduce the ventricular rate by increasing block in the A-V node (digitalis/verapamil) or act by directly affecting the atria by reducing the atrial rate or converting flutter to sinus rhythm (1a and 1c antiarrthythmic drugs). Treatment that reduces the atrial rate may cause 1:1 A-V conduction. Quinidine and disopyramide are well known for increasing A-V conduction to 1:1 in some patients, because of their anticholinergic effect on the A-V node. Flecainide, a 1c antiarrhythmic drug, slows down atrial conduction, reducing flutter rate by 1/3. Clinical studies have shown flecainide to be effective in converting atrial fibrillation, atrial tachycardia, A-V reentry and A-V nodal reentry tachycardias to sinus rhythm. The effect on atrial flutter has been less impressive. Flecainide prolongs A-V conduction and increases Wenckebach cycle length. In spite of this, 1:1 A-V conduction may occur during treatment with intravenous flecainide for atrial flutter. We present a case where this is demonstrated and review the literature.
authors.forename: M
authors.initials: M
authors.lastname: Heldal
authors.forename: O M
authors.initials: OM
authors.lastname: Orning
mesh_terms: D000368:Aged; D001282:Atrial Flutter / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D005424:Flecainide / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
chemical_list: D005424:Flecainide
vernacular_title: Atrieflutter med 1:1 AV-overledning under intravenøs flekainidbehandling.