Recurrent deep vein thrombosis and Addison's disease in "primary" antiphospholipid syndrome.
We describe a 43-year-old Caucasian man who, after a 10 year history of recurrent deep vein thromboses and pulmonary emboli, was found to have a "lupus anticoagulant" and marked elevation of antibodies to cardiolipin. He subsequently developed skin and buccal pigmentation and biochemical investigations revealed the presence of Addison's disease. The relationship of the Addison's disease to the recurrent thrombotic events in the presence of antibodies to phospholipids is discussed.
Asherson
R A
RA
Lupus Arthritis Research Unit, Rayne Institute, St. Thomas' Hospital, London, England.
Hughes
G R
GR
D000224:Addison Disease / Q000150:complications / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008297:Male; D011655:Pulmonary Embolism / Q000209:etiology / Q000276:immunology; D012008:Recurrence; D013924:Thrombophlebitis / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor