[Incidence of monoclonal components in lymphoproliferative syndromes. Apropos of 234 cases ].
A series of 234 sera from 104 patients with non-Hodgkin's lymphoma (NHL), 77 with Hodgkin's disease (HD) and 53 with chronic lymphocytic leukaemia (CLL) was studied by cellulose acetate gel electrophoresis, agarose gel electrophoresis, immunoelectrophoresis and electroimmunodiffusion, in order to assess the incidence and type of monoclonal components (MC) in these diseases. Monoclonal component was found by cellulose acetate gel electrophoresis in 22 of the 234 cases studied (9.8%); agarose gel electrophoresis disclosed MC in 22 other cases (18.8%), all of them showing rates lower than 5.0 g/L. MC was present in 29 of the 104 NHL cases (27.9%), it being characterised as IgM in 16 patients and IgG in 13 others. The MC was observed in 13 of the 21 cases of lymphoplasmacytoid forms, but it was less conspicuous in the remaining histological forms. With regard to HD, MC was present in 5 cases (6.5%), of IgG, type in all instances, and in 10 of the 53 CLL patients (18.9%), IgG in 8 and IgM in two other cases. The methods used in the present study made it possible to detect and characterise MC in about 20% of the lymphoproliferative syndromes studied. It can be inferred that the use of more sensitive techniques would disclose the presence of MC in the majority of B-cell lymphoproliferative syndromes.
Giraldo
M P
MP
Cortés
M T
MT
Rubio-Félix
D
D
Giralt
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001797:Blood Protein Electrophoresis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood*; D008223:Lymphoma / Q000097:blood* / Q000145:classification; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D009363:Neoplasm Proteins
Incidencia de componentes monoclonales en síndromes linfoproliferativos. A propósito de 234 casos.