title: Clinical, endocrinological and spermatological studies after endotoxin in the ram.
abstract: Eight rams were injected intravenously with endotoxin from Salmonella typhimurium. Blood plasma was analysed for the contents of 15-ketodihydro-PGF2 alpha, LH, testosterone, calcium and total amount of white blood cells. Semen was examined for motility, concentration, volume and morphological appearance. After castration at 4 or 16 weeks the testes were examined histologically. The total white blood cells and the calcium levels as well as LH and testosterone decreased and the levels of 15-ketodihydro-PGF2 alpha rose after the endotoxin administration. The examination of the semen showed a significant decrease in motility and a significant increase in abnormal sperm heads. The histological examination showed a slight degeneration in the seminiferous epithelium in the rams castrated at 4 weeks after the endotoxin administration; this degeneration was not seen in the rams castrated at 16 weeks. The present results indicate that endotoxin seems to exert a negative effect on the genital functions of the ram; the changes in LH and testosterone are very similar to those seen after heat induced stress. The histological changes indicate a short-lasting mild degeneration in the seminiferous epithelium.
authors.forename: M
authors.initials: M
authors.lastname: Wallgren
authors.forename: H
authors.initials: H
authors.lastname: Kindahl
authors.forename: K
authors.initials: K
authors.lastname: Larsson
mesh_terms: D000818:Animals; D001831:Body Temperature; D004731:Endotoxins / Q000633:toxicity*; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D012098:Reproduction; D012486:Salmonella typhimurium; D012661:Semen / Q000502:physiology*; D012756:Sheep / Q000097:blood / Q000502:physiology*
chemical_list: D004731:Endotoxins