Immunosialadenitis (Sjögren's syndrome) and lymphoproliferation.
The association of primary salivary gland non-Hodgkin's lymphoma (NHL) and immunosialadenitis (myoepithelial sialadenitis, MESA) is well recognized. Within MESA the whole spectrum of lymphoproliferation starting with a prelymphoma transforming into an early lymphoma and later on into a manifest lymphoma can be observed. These lymphomas represent so-called low grade B-cell lymphomas of mucosa associated lymphoid tissue (MALT), an entity also including lymphoplasmocytoid immunocytoma according to the Kiel classification of NHL. In a few patients a transition into a high grade B-cell lymphoma may occur. The recognition of early stages of lymphomas and their distinction from reactive MESA is only possible by application of immunohistological methods.
Schmid
U
U
Department of Pathology, Kantonsspital, St. Gallen, Switzerland.
Lennert
K
K
Gloor
F
F
D001402:B-Lymphocytes / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D012466:Salivary Gland Diseases / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology; D012793:Sialadenitis / Q000276:immunology / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains