title: [Invasive tumors of the bladder. A study of 56 cases treated at the Gustave-Roussy Institute by total cystectomy and radiotherapy].
abstract: Between July 1973 and December 1984, 56 patients with invasive bladder cancer were treated at the Gustave-Roussy Institute by total cystectomy and, generally, radiotherapy (45 patients). Four modalities of irradiation were used: preoperative flash (21 patients), preoperative flash and postoperative irradiation (9 patients), preoperative irradiation according to conventional fractionation (12 patients), postoperative irradiation (3 patients). The actuarial 5 year survival for all of the patients treated was 28%. The essential prognostic factors were depth of emboli. Analysis of the deaths revealed loco-regional recurrence in 8 patients (14%), metastases in 11 patients (20%) another cause in 14 patients (24%); treatment appeared to be directly involved in 13 cases. However, toxicity has been considerably reduced since 1980, due to more rigorous patient selection for total cystectomy, improvement in pre- and postoperative intensive care and by the use of a radiotherapy protocol no longer involving large concentrated fractions.
authors.affiliation: Département de Radiothérapie, Institut Gustave-Roussy, Villejuif.
authors.forename: Y
authors.initials: Y
authors.lastname: Raoul
authors.forename: P
authors.initials: P
authors.lastname: Wibault
authors.forename: S
authors.initials: S
authors.lastname: Giacchetti
authors.forename: B
authors.initials: B
authors.lastname: Court
authors.forename: B
authors.initials: B
authors.lastname: Perrin
authors.forename: J P
authors.initials: JP
authors.lastname: Travagli
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000601:surgery; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011882:Radiotherapy, High-Energy; D001743:Urinary Bladder / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
vernacular_title: Tumeurs infiltrantes de vessie. Etude de cinquante-six cas traités à l'Institut Gustave-Roussy par cystectomie totale et radiothérapie.