Spontaneous release of interleukin-1 (IL-1) from medullary mononuclear cells of pagetic subjects.
The Authors examined interleukin 1 (IL-1) secretion from the peripheral and medullary mononuclear cells, obtained with sequential separation on Ficoll-Hypaque and 45% Percoll gradient, in 6 pagetic subjects and 6 normal controls. Both peripheral and medullary cells from pagetic subjects showed a significantly greater IL-1 production after stimulation with lipopolysaccharides (LPS); moreover, we observed a spontaneous IL-1 release from medullary cells in pagetic subjects but not in normal controls. These findings suggest a possible role of IL-1 in the elevated bone turnover of Paget's disease of bone.
Pioli
G
G
Cattedra di Clinica Medica II, Universitá di Parma, Italy.
Girasole
G
G
Pedrazzoni
M
M
Sansoni
P
P
Erroi
A
A
Davoli
L
L
Ciotti
G
G
Mantovani
A
A
Passeri
M
M
D000368:Aged; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000378:metabolism*
D007375:Interleukin-1