Toxic epidermal necrolysis. A comprehensive approach. Multidisciplinary management in a burn center.
Toxic Epidermal Necrolysis (TEN) is a life-threatening disorder with reported mortality rates of 25-60 percent in pediatric patients. The authors report on their experience in managing six children using a standardized treatment protocol in the intensive care unit of a regional burn center. Areas of sloughed skin were covered with porcine xenograft (pig skin) until reepithelialization was complete. There was one death in the series, and one child had ophthalmologic complications. Treatment in a multidisciplinary burn center is recommended for children with TEN.
Taylor
J A
JA
Department of Pediatrics, Charlotte Memorial Hospital, North Carolina 28282.
Grube
B
B
Heimbach
D M
DM
Bergman
A B
AB
D002053:Burn Units; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D004750:Enteral Nutrition; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D014183:Transplantation, Heterologous