title: [Stages of B-lymphocyte differentiation in acute lymphoblastic leukemia].
abstract: Blasts phenotype was determined in 61 children with the acute lymphoblastic leukemia. Non-T-cell acute lymphoblastic leukemia was diagnosed in 51 children. Stages of blasts differentiation were determined with the aid of monoclonal antibodies set using alkaline phosphatase-anti-alkaline phosphatase technique. Blasts in 50 patients belonged to B subpopulation confirmed by the presence of panB CD19 and CD22 antigens. Common antigen was seen in 76.5% of the examined patients with non-T-cell acute lymphoblastic leukemia. Cases of non-T-cell acute lymphoblastic leukemia were divided into 8 subgroups depending on the antigens of B-cells differentiation. An identification of pre-B subgroups of the acute lymphoblastic leukemia indicates heterogenicity of the acute lymphoblastic leukemias in childhood and enables their classification into groups corresponding to the early stages of lymphoblasts maturation.
authors.forename: M
authors.initials: M
authors.lastname: Koehler
authors.forename: H
authors.initials: H
authors.lastname: Bubała
authors.forename: D
authors.initials: D
authors.lastname: Sońta-Jakimczyk
authors.forename: E
authors.initials: E
authors.lastname: Guzikowska
authors.forename: A
authors.initials: A
authors.lastname: Janik-Moszant
authors.forename: M
authors.initials: M
authors.lastname: Wieczorek
authors.forename: J
authors.initials: J
authors.lastname: Hołowiecki
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype
chemical_list: D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D014408:Biomarkers, Tumor
vernacular_title: Stadia zróznicowania limfocytów "B" w ostrej białaczce limfoblastycznej.