Studies on the development of novel anti-leprous chemotherapeutics using nude mice with special reference to a new quinolone carboxylic acid, AT-4140.
In order to develop a novel drug for antileprosy chemotherapy, the inhibitory effects of three synthesized compounds, a supplied antituberculous one and three quinolone carboxylic acids were examined on the growth of leprosy bacilli inoculated into the footpads of nude mice. Amongst them, a new quinolone carboxylic acid, AT-4140 whose chemical structure was 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3, 5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid strongly inhibited the growth of leprosy bacilli at doses of 15 and 30 mg/kg. Whereas, the effect of Ofloxacin used as a positive control was limited at the same doses.
Tsutsumi
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S
Gidoh
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D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D005528:Foot / Q000382:microbiology; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D008819:Mice, Nude; D009166:Mycobacterium leprae / Q000187:drug effects
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C061363:sparfloxacin