Pressor, norepinephrine, and pituitary responses to two TRH doses in Alzheimer's disease and normal older men.
Changes in blood pressure (BP), plasma norepinephrine (NE), serum prolactin (PRL), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) associated with infusions of two thyrotropin-releasing hormone (TRH) doses (0.1 mg, 0.5 mg) were examined in 10 men with early-onset Alzheimer's disease (AD) and nine normal matched controls. During the first 5 min after TRH infusion, significant increases from baseline in systolic BP (p less than 0.001), diastolic BP (p less than 0.001), and plasma NE (p less than 0.006) occurred in the study subjects. The magnitude of the BP and NE responses did not differ significantly as a function of TRH dose (p greater than 0.3). Diastolic pressor responses to TRH were substantially blunted in AD subjects relative to controls, after both the 0.1-mg (p less than 0.003) and 0.5-mg (p less than 0.02) doses. There were trends toward attenuated responses in the AD subjects for systolic BP (p less than 0.09) and plasma NE (p less than 0.07). Significant increments in serum PRL, LH, and FSH (all p less than 0.001) also occurred after TRH, but the magnitude of the hormone responses did not differ significantly between the AD and the normal subjects (p greater than 0.18). These results suggest the possibility that TRH-evoked activation of the sympathetic nervous system (SNS), as reflected by pressor and plasma NE responses, may be attenuated in men with early-onset AD.
Lampe
T H
TH
GRECC 182(B), American Lake VA Medical Center, Tacoma, WA 98493.
Veith
R C
RC
Plymate
S R
SR
Risse
S C
SC
Kopeikin
H
H
Cubberley
L
L
Raskind
M A
MA
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D010902:Pituitary Gland / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage* / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D009638:Norepinephrine