The Liverpool chimaera.
A dispermic human chimaera is described who is a fertile female XX/XY chimaera. The chimaera was discovered due to anomalies found during routine antenatal testing. The patient had two red cell populations differing in three blood group systems; ABO, Rh and MN. Analysis of cultured lymphocytes showed 70% of cells to have the 46, XY male karyotype and analysis of cultured skin cells showed 30% of cells to have the 46, XY karyotype.
Bromilow
I M
IM
Mersey Regional Blood Transfusion Service, Liverpool, UK.
Duguid
J
J
D000017:ABO Blood-Group System / Q000235:genetics; D000328:Adult; D002678:Chimera; D004739:England; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000235:genetics; D007621:Karyotyping; D008951:MNSs Blood-Group System / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000235:genetics
D000017:ABO Blood-Group System; D006680:HLA Antigens; D007132:Immunoglobulin Isotypes; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System