title: Neutron fibre diffraction study of DNA hydration.
abstract: Interactions with water are crucial to the conformation assumed by the DNA double helix. The location of water around the D conformation has been investigated in a neutron fibre diffraction study which shows that water is ordered in the minor groove of the DNA. The D conformation is important since its occurrence is limited to specific DNA base pair sequences which have been identified as functionally significant. This study is of particular interest because the D conformation has not been reported in single crystal studies of oligonucleotides.
authors.affiliation: Department of Physics, University of Keele, Staffordshire, UK.
authors.forename: V T
authors.initials: VT
authors.lastname: Forsyth
authors.forename: A
authors.initials: A
authors.lastname: Mahendrasingam
authors.forename: W J
authors.initials: WJ
authors.lastname: Pigram
authors.forename: R J
authors.initials: RJ
authors.lastname: Greenall
authors.forename: K
authors.initials: K
authors.lastname: Bellamy
authors.forename: W
authors.initials: W
authors.lastname: Fuller
authors.forename: S A
authors.initials: SA
authors.lastname: Mason
mesh_terms: D004247:DNA / Q000737:chemistry*; D005583:Fourier Analysis; D009502:Neutrons; D009690:Nucleic Acid Conformation; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D004247:DNA