Antileukemic effect of low-dose harringtonine.
The effect of harringtonine (HA) in various concentrations on HL-60 was evaluated. 0.10 microgram/ml HA showed a strong cell killing effect, and 0.025 microgram/ml HA a weak differentiation induction accompanied by cell growth retardation. Differentiation induction did not occur in 5 other human leukemic cell lines. We consider that antileukemic effect of HA is cytotoxicity, not differentiation induction.
Chen
S S
SS
Wang
P
P
Fu
J Y
JY
Chen
L L
LL
Zhao
F S
FS
Shan
F X
FX
D000470:Alkaloids / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D006248:Harringtonines / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000470:Alkaloids; D006248:Harringtonines