title: Lack of a difference between ketanserin and ritanserin in central vs. peripheral serotonin receptor antagonism.
abstract: Ketanserin and ritanserin antagonized with similar potency the pressor response to serotonin in pithed rats, a measure of antagonism of vascular 5HT2 receptors. Both compounds also antagonized the elevation of serum corticosterone concentration by quipazine, a centrally acting serotonin agonist; higher doses of both antagonists were needed, but ketanserin was not less potent than ritanserin. Earlier suggestions that ketanserin mainly blocks peripheral serotonin receptors and that ritanserin mainly blocks central serotonin receptors seem unfounded.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors.forename: M L
authors.initials: ML
authors.lastname: Cohen
authors.forename: W L
authors.initials: WL
authors.lastname: Bloomquist
authors.forename: H D
authors.initials: HD
authors.lastname: Snoddy
authors.forename: R W
authors.initials: RW
authors.lastname: Fuller
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011814:Quipazine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D016713:Ritanserin; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016713:Ritanserin; D012701:Serotonin; D011814:Quipazine; D007650:Ketanserin; D003345:Corticosterone