Analysis of T lymphocyte subsets in tamarins with colitis and colon cancer.
The cotton-top tamarin, Saguinus oedipus, serves as an animal model for the study of human colon cancer. This New World monkey has a high incidence of colitis and colon cancer that develops spontaneously. Evidence suggests that these diseases may be the result of a virally induced immunodeficiency. We have shown that T4+/T8+ cell ratios are significantly altered in tamarins with acute colitis and colon cancers. The T4+/T8+ ratios were 1.50 +/- 0.09, 0.70 +/- 0.05, and 0.48 +/- 0.05 for negative controls, acute colitis, and cancer positive tamarins, respectively. Statistical analysis showed a significant difference (p less than or equal to .0005) between negative controls vs. acute colitis and cancer positive groups.
Lee
Y C
YC
Medical and Health Sciences Division, Oak Ridge Associated Universities, TN 37831-0117.
Lawless
D
D
Crook
J E
JE
Clapp
N K
NK
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D016827:CD8 Antigens; D002143:Callitrichinae / Q000276:immunology*; D003092:Colitis / Q000276:immunology* / Q000662:veterinary; D003110:Colonic Neoplasms / Q000276:immunology* / Q000662:veterinary; D004195:Disease Models, Animal; D008992:Monkey Diseases / Q000276:immunology; D012452:Saguinus / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification*
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens