Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice.
The present study examined the effect of chronic L-deprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 2 x 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L-deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16-week period, and did not alter the rate of restoration of the level of striatal dopamine.
Wiener
H L
HL
Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Ward's Island, New York 10035.
Hashim
A
A
Lajtha
A
A
Sershen
H
H
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010302:Parkinson Disease, Secondary / Q000188:drug therapy / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology*; D011725:Pyridines / Q000633:toxicity*; D012642:Selegiline / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D010627:Phenethylamines; D011725:Pyridines; D015102:3,4-Dihydroxyphenylacetic Acid; D012642:Selegiline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine