[Hepatitis B vaccination in alcoholics].
The immune response after HB vaccination (20 micrograms, 3 times) was investigated in 15 alcoholics and the immunological background was also studied before the vaccination in some of these cases. Anti-HBs was detected in only 8 (53.3%) out of 15 vaccinated alcoholics and the anti-HBs titers of these 8 responders were less than 16 cut off index at the last observation. Immunologically, peripheral lymphocyte count and/or the OKT4/OKT8 ratio of lymphocytes in 2 alcoholics (non-responders to vaccination) were lower than those in a control case (good responder). But, there were no differences in serum anti-HAV, anti-EBNA positive rates, immunoglobulin levels and blastogenesis by PHA, Con-A between responders and non-responders. These data suggest that poor response to HB vaccination is probably due to an impaired cellular immunity in alcoholics and the necessity of re-vaccination for no or low responders should be considered.
Maruyama
N
N
Sata
M
M
Ishii
K
K
Atono
Y
Y
Ono
K
K
Matuda
T
T
Suzuki
H
H
Muraoka
H
H
Nakano
H
H
Hino
K
K
D000328:Adult; D000437:Alcoholism / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines