Sister chromatid exchanges in adult epilepsy patients on valproate monotherapy.
Sister chromatid exchanges (SCE) were studied in peripheral lymphocyte cultures of 13 adult male patients with epilepsy treated chronically with valproate (VPA) and in their matched controls. No statistically significant differences in SCE level were found between the patient and control groups, indicating a lack of mutagenic potential of VPA within the therapeutic dose range.
Schaumann
B A
BA
Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417.
Winge
V B
VB
Garry
V F
VF
D000328:Adult; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid