[Malignant hypertensive retinopathy in spontaneously hypertensive stroke-prone rats. Effect of treatment with cicletanine].
Stroke-Prone spontaneously hypertensive rat strain (SHR-SP) always develops hypertensive retinopathy. The aim of the present work was to study the activity of a new antihypertensive drug, a synthetic furopyridine: cicletanine, in retinal hypertensive morphological lesions. The experiment was performed in 39 rats SHR-SP/A3N Iffa Credo, 11 weeks old, divided into 3 groups: group 1 was the control group, groups 2 and 3 were orally treated with cicletanine (respectively 100 and 150 mg/kg). All the rats had free access to tap water containing 1 p. 100 NaCl. During 6 weeks, blood pressure, body weight and survival were recorded, then all the rats were sacrificed. The eyes were removed, the posterior pole collected and fixed with Trump liquid for transmission election microscopy. In the SHR-SP control group, each layer showed neural body and/or process lesions: in the ganglion cell layer, some ganglion cells realized cytoid bodies corresponding to a lysed cell with nucleus degeneration, most of the axons were destroyed. In the inner and outer plexiform layers, most of the contacts between processes were lost because of fibrinous deposits. Numerous synapses were destroyed in the outer plexiform layer. These findings might explain the numerous dense bodies in the inner rod segment and the vesiculation of the rod outer segment. The capillaries showed markedly hypertensive lesions. Whereas, in both treated groups, rare and animal lesions were observed. The fact that these lesions were so few and so unimportant after 6 weeks of treatment, as well as for the photoreceptors which remained unimpaired, is closely related to cicletanine therapy, since it was so even though the treatment had been started with an already high blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Ruchoux
M M
MM
Laboratoire de neuropathologie, CHU Bretonneau, Tours, France.
Droy-Lefaix
M T
MT
Bakri
F
F
Berthet
P
P
Bosquet
D
D
Lhuintre
Y
Y
D000818:Animals; D004232:Diuretics / Q000627:therapeutic use*; D006974:Hypertension, Malignant / Q000188:drug therapy*; D008854:Microscopy, Electron; D011725:Pyridines; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D012164:Retinal Diseases / Q000188:drug therapy* / Q000473:pathology
D004232:Diuretics; D011725:Pyridines; C038068:cicletanine
Rétinopathie hypertensive maligne chez le rat "stroke-prone" spontanément hypertendu. Effet du traitement par le ciclétanine.