Stimulation of heart contractility by supernatants from lectin-activated lymphocytes. Role of IL-2.
The positive inotropic effect of cell-free supernatants from lectin-activated lymphocytes is lost by dialysis and can be partially restored by addition of arachidonic acid (AA). Interleukin-2 (IL-2) in the presence of AA could stimulate the response of the heart while the interferons (alpha-IFN or gamma-IFN) were ineffective. The activity of PHA-L-SN and that of IL-2 + AA was neutralized by anti-IL-2 MAb. These results suggest a key role for IL-2 in the stimulation of heart contractility by supernatants from activated lymphocytes.
Fink
S B
SB
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Finiasz
M
M
Sterin-Borda
L
L
Borda
E
E
de Bracco
M M
MM
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D007376:Interleukin-2 / Q000502:physiology*; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical
D001095:Arachidonic Acids; D007370:Interferon Type I; D007376:Interleukin-2; D037102:Lectins; D016718:Arachidonic Acid