Cyclosporin: poorly tolerated in familial Mediterranean fever.
Cyclosporin is poorly tolerated in patients with amyloidosis due to familial mediterranean fever who are receiving colchicine. There is a high incidence of gastrointestinal side-effects and muscle weakness, both of which are reversible on stopping cyclosporin. Thus in patients with amyloidosis secondary to familial mediterranean fever treated with colchicine, the use of cyclosporin as an immunosuppressive agent may be restricted.
Cohen
S L
SL
Renal Transplantation Unit, Beilinson Hospital, Petach Tiqvah, Israel.
Boner
G
G
Shmueli
D
D
Yusim
A
A
Rosenfeld
J
J
Shapira
Z
Z
D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy / Q000209:etiology*; D003078:Colchicine / Q000008:administration & dosage; D003524:Cyclosporins / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced; D004359:Drug Therapy, Combination; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000139:chemically induced
D003524:Cyclosporins; D003078:Colchicine