title: Increased expression of HLA-DR antigen on alveolar macrophages in pulmonary diseases.
abstract: The expression of HLA-DR antigen on alveolar macrophages obtained by bronchoalveolar lavage in healthy controls and patients with different diseases was investigated, using cytofluorographic analysis and phykoerythrin conjugated monoclonal mouse anti-human HLA-DR antibody. Alveolar macrophages in patients with extrinsic allergic alveolitis (n = 4), idiopathic lung fibrosis (n = 4), sarcoidosis (n = 6), rheumatoid lung disease (n = 6) and pulmonary infection (n = 5) showed increased density of HLA-DR antigen expression compared to healthy control subjects (n = 5). The increased expression of HLA-DR antigen on alveolar macrophages confirms the importance of these cells for recognition of antigens and immunological responses in different pulmonary diseases.
authors.affiliation: Pulmonary Department, KH Lainz, Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Popp
authors.forename: O
authors.initials: O
authors.lastname: Braun
authors.forename: H
authors.initials: H
authors.lastname: Zwick
authors.forename: H
authors.initials: H
authors.lastname: Rauscher
authors.forename: L
authors.initials: L
authors.lastname: Ritschka
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D002452:Cell Count; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000276:immunology* / Q000473:pathology
chemical_list: D006684:HLA-DR Antigens