[Long-term effect of various nitrates in ischemic heart disease and latent heart failure].
In 24 patients (pts) with proven coronary artery disease, stable angina pectoris (AP) and elevated pulmonary artery pressure (PAP) during bicycle exercise, the acute and chronic (4 and 8 months) effects of several long-acting nitrates in different dosages: 50-300 mg pentaerythrityltetranitrate (PETN) or 40-120 mg isosorbide dinitrate (ISDN) were evaluated in comparison to sublingual nitroglycerin. Nitroglycerin was about 30%-40% more effective than PETN and ISDN with regard to pulmonary artery pressure at exercise. Beneficial effects of both long-acting nitrates were shown with regard to the number of anginal attacks, nitroglycerin consumption, and ST-segment depression both during short- and long-term treatment. Both nitrates decreased exercise pulmonary artery pressure by 15%-20%, at acute testing and during chronic therapy. There was no difference with respect to the long-term effects of both long-acting nitrates. However, more side-effects were observed during ISDN treatment. There were no signs of nitrate tolerance development with the therapy schedules under investigation.
Assmann
I
I
Abteilung für Kardiologie, Medizinische Akademie Erfurt, DDR.
Dueck
K D
KD
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010417:Pentaerythritol Tetranitrate / Q000031:analogs & derivatives*; D011409:Propylene Glycols / Q000008:administration & dosage*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D014665:Vasodilator Agents / Q000008:administration & dosage*
D011409:Propylene Glycols; D014665:Vasodilator Agents; D010417:Pentaerythritol Tetranitrate; C100210:pentrinitrol; D007548:Isosorbide Dinitrate
Untersuchungen zum Langzeiteffekt verschiedener Nitrate bei ischämischer Herzkrankheit und latenter Herzinsuffizienz.