[The protective activity of the detoxified lipopolysaccharide of Neisseria meningitidis serogroup A in in vivo experiments].
The immunogenic potency, toxicity, homologous and heterologous protective activity of lipopolysaccharide preparations obtained from serogroup A N. meningitidis (LPS A) were studied in animal experiments. These preparations were shown to possess very high protective activity. The alkaline treatment of native LPS A decreased the toxicity of the preparation almost 20 times and did not affect its immunogenic potency. Detoxified LPS A was capable of protecting mice from fatal meningococcemia resulting from infection with N. meningitidis strains, serogroups A, B and C; the adsorption of the preparation on aluminium hydroxide did not affect its protective activity. In view of the properties of detoxified LPS A revealed in this investigation, it may be regarded as a possible vaccinal preparation.
Del'vig
A A
AA
Krasnoproshina
L I
LI
Bobyleva
G V
GV
Kuvakina
V I
VI
D000327:Adsorption; D000536:Aluminum Hydroxide; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000276:immunology* / Q000627:therapeutic use / Q000633:toxicity; D008589:Meningococcal Infections / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009345:Neisseria meningitidis / Q000276:immunology*; D018805:Sepsis / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000276:immunology* / Q000627:therapeutic use / Q000633:toxicity
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated; D000536:Aluminum Hydroxide
Protektivnaia aktivnost' detoksitsirovannogo lipopolisakharida Neisseria meningitidis serogruppy A v opytakh in vivo.