Pharmacokinetics of cyclosporin in man following a single oral dose: relationship to body fat content.
We have investigated the pharmacokinetics of the immunosuppressive drug cyclosporin in 11 patients receiving regular dialysis therapy. After a single oral dose of cyclosporin, whole blood concentrations were measured at regular intervals for 24 h. Body fat content was estimated in each subject from the measurement of skin-fold thickness and mid-arm circumference. In ten of the 11 patients there was a relatively uniform response in the increase of cyclosporin blood concentration to a peak within the first 6 h. Calculated area under the blood concentration curve did not correlate with total bodyweight, but correlated strongly with body fat content as well as fat-free mass. This study suggests that more predictable blood concentrations of cyclosporin might be achieved if the initial dose were calculated on the basis of fat-free mass rather than total bodyweight.
Waters
M R
MR
Wessex Regional Renal and Transplant Unit, University of Southampton, St Mary's Hospital, Portsmouth, UK.
Albano
J D
JD
Sharman
V L
VL
Raman
G V
GV
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001682:Biological Availability; D001835:Body Weight; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012885:Skinfold Thickness
D003524:Cyclosporins