title: Antitumor-promoting activity of eperisone.
abstract: Eperisone, a Ca2+ entry blocker, suppressed the action of tumor promoter in vitro and in vivo, inhibited tumor-promoter-stimulated 32Pi incorporation into phospholipids of cultured cells, and also proved to have antitumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene plus tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
authors.affiliation: Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Takayasu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: A
authors.initials: A
authors.lastname: Iwashima
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000517:prevention & control; D010710:Phosphates / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011427:Propiophenones / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D010710:Phosphates; D010743:Phospholipids; D011427:Propiophenones; C030848:eperisone; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate