Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes.
Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had reduced antibody and cell-mediated immune responses to the organism. Mortality in these mice was 100% following challenge with 1.5 x 10(5) trypanosomes, whereas controls had a 50% survival rate, indicating that T-cell activation and viable L3T4+ (CD4+) T lymphocytes are essential for the development of resistance.
Araujo
F G
FG
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000937:Antigen-Antibody Reactions; D000945:Antigens, Differentiation, T-Lymphocyte; D000953:Antigens, Protozoan / Q000008:administration & dosage / Q000276:immunology; D002470:Cell Survival; D014355:Chagas Disease / Q000209:etiology / Q000276:immunology*; D007113:Immunity, Innate; D051379:Mice; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology / Q000502:physiology; D014349:Trypanosoma cruzi / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000953:Antigens, Protozoan