title: A tree reconstruction method that is economical in the number of pairwise comparisons used.
abstract: A fast method for reconstructing phylogenies from distance data is presented. The method is economical in the number of pairwise comparisons needed. It can be combined with a new phylogenetic alignment procedure to yield an algorithm that gives a complete history of a set of homologous sequences. The method is applicable to very large distance matrices. An auxiliary program was developed that simplifies large phylogenies without ignoring biologically essential features. A set of 213 globins from vertebrates, plants, and Vitreoscilla (a prokaryote) were analyzed using this method.
authors.affiliation: NIEHS, Research Triangle Park, North Carolina 27709.
authors.forename: J
authors.initials: J
authors.lastname: Hein
mesh_terms: D000465:Algorithms; D010802:Phylogeny; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid