[Effect of inhibitors of polyamine biosynthesis and of exogenous polyamines on the mitogenic effect of epidermal growth factor in a hepatocyte culture].
It was established that difluoromethylornithine (DFMO) and methylglyoxal-bis(guanylhydrazone) blocked the mitogenic response of hepatocytes to epidermal growth factor. This effect of inhibitors, especially DFMO, has been prevented by exogenic putrescine, spermidine or spermine. But neither blocking action of inhibitors nor preventing effect of polyamines associated with changes of epidermal growth factor binding to hepatocytes.
Osipova
L A
LA
Nemliĭ
N I
NI
Gridina
N Ia
NIa
Shliakhovenko
V A
VA
D000818:Animals; D015317:Biogenic Polyamines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004347:Drug Interactions; D000518:Eflornithine / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008935:Mitoguazone / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D011073:Polyamines / Q000494:pharmacology*
D015317:Biogenic Polyamines; D011073:Polyamines; D004815:Epidermal Growth Factor; D004247:DNA; D008935:Mitoguazone; D000518:Eflornithine
Vliianie ingibitorov biosinteza poliaminov i ékzogennykh poliaminov na mitogennyĭ éffekt épidermal'nogo faktora rosta v kul'ture gepatotsitov.