title: Lupus anticoagulant and cerebrovascular accident in a patient with neurofibromatosis.
abstract: This report describes the case of a young woman with biopsy-proven neurofibromatosis and a history of recurrent fetal wastage who had sudden onset of slurred speech and left-sided weakness. CT scan and MRI revealed multiple cerebral infarcts. Laboratory evaluation revealed lupus anticoagulant and high levels of anticardiolipin antibody. This case illustrates the thrombotic tendencies seen in patients with lupus anticoagulant and anticardiolipin antibody, and is the first reported case of LA in association with neurofibromatosis.
authors.affiliation: Coagulation Special Studies Laboratory, Medical College of Virginia, Richmond.
authors.forename: M E
authors.initials: ME
authors.lastname: Carr
authors.forename: C W
authors.initials: CW
authors.lastname: Howe
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D001780:Blood Coagulation Tests; D002308:Cardiolipins / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005313:Fetal Death / Q000097:blood; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D009456:Neurofibromatosis 1 / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D014057:Tomography, X-Ray Computed
chemical_list: D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor