[Comparative study of the bronchodilator effect of inhaled fenoterol and aerosol salbutamol in patients with chronic bronchial asthma].
The bronchodilator effects of inhaled fenoterol (FI) and salbutamol aerosol (S) in 15 patients (8 male and 7 female with a median age of 44 +/- 13 years), diagnosed as suffering from asthma, were studied using spirometry (determining FEV1, FEF 25-75% and FVC) and flow volume curves (PEF, MEF 75% and MEF 25%). The mean theroric rate of FEV1, PEF, MEF 75% was defined as the theoric rate of the obstruction of central airways (PCA%) and the mean of FVC, FEF 25-75% and MEF 25% rates defined as the rate of the theoric obstruction of the peripheral airways (PPA%). Basal and 5, 15, 30, 60, 120, 240, 360, 480 minute determinations were done, after the administration of 200 mcg of S in the conventional way on two different days. The statistic study carried out using the "u" test of Mann-Whytney. No statistically significant differences in intensity, onset nor duration of the effect between both drugs were found. We concluded that FI is a drug of great utility in treatment of asthmatic patients and one which allowed, because of the easy inhaling technique, the use of beta 2 adrenergic drugs in a mayor number of patients who would otherwise have to resort to an alternative form of administration.
Valdés Cuadrado
L
L
Salgueiro Rodriguez
M
M
Alvarez-Calderón Prat
P
P
Arias Castells
M R
MR
Berdugo Oviedo
M
M
Rabuñal Rey
R
R
Ventosa Rial
J
J
Rodríguez Suarez
J R
JR
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000336:Aerosols; D005280:Fenoterol; D000420:Albuterol
Estudio comparativo del efecto broncodilatador entre fenoterol inhaletas y salbutamol aerosol en pacientes con asma bronquial crónica.