title: 99mTc(Cu)-mannitol complex: a new agent for dynamic renal function studies.
abstract: Mannitol has been labeled with 99mTc by using cuprous chloride as a reducing agent. Blood and kidney clearance of 99mTc(Cu)-mannitol was slightly faster than that of 99mTc(Sn)-DPTA in rat and maximum radioactivity ratio of kidneys to blood was 84.6 at 5 min. A comparative study of 99mTc(Cu)-mannitol, 99mTc(Sn)-DTPA was made in rabbits by taking serial images of kidneys and bladder with a gamma camera. Results show superiority of 99mTc(Cu)-mannitol over other agents for dynamic renal function studies.
authors.affiliation: Institute of Nuclear Medicine and Allied Sciences, Delhi-, India.
authors.forename: U P
authors.initials: UP
authors.lastname: Chauhan
authors.forename: J
authors.initials: J
authors.lastname: Chander
authors.forename: P
authors.initials: P
authors.lastname: Mishra
authors.forename: R C
authors.initials: RC
authors.lastname: Sarin
authors.forename: R V
authors.initials: RV
authors.lastname: Narayanan
authors.forename: B
authors.initials: B
authors.lastname: Singh
mesh_terms: D000818:Animals; D007668:Kidney / Q000000981:diagnostic imaging; D008353:Mannitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011817:Rabbits; D011866:Radioisotope Renography; D051381:Rats; D013667:Technetium; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives*; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000000981:diagnostic imaging
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C059584:technetium Tc 99m mannitol; C034230:technetium Tc 99m-Sn-DTPA; D008353:Mannitol; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate