title: Ketamine for intravenous regional anesthesia.
abstract: We studied ketamine intravenous regional anesthesia of the upper extremity in volunteers using concentrations of 0.5%, 0.3%, and 0.2%. Ketamine 0.5 and 0.3% produced adequate intravenous regional anesthesia. Anesthesia was inadequate when a 0.2% concentration was used. However, although the 0.3% concentration provides complete sympathetic, sensory, and motor blockade when injected into the isolated extremity, unpleasant psychotomimetic effects after the release of the tourniquet limit the usefulness of this use of ketamine. Ketamine cannot be recommended for intravenous regional anesthesia unless these unpleasant side effects are abolished or controlled by means of pharmacologic adjuvants.
authors.affiliation: Department of Anesthesiology, University of Illinois College of Medicine, Chicago.
authors.forename: Z
authors.initials: Z
authors.lastname: Durrani
authors.forename: A P
authors.initials: AP
authors.lastname: Winnie
authors.forename: E K
authors.initials: EK
authors.lastname: Zsigmond
authors.forename: M L
authors.initials: ML
authors.lastname: Burnett
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D006801:Humans; D007649:Ketamine / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male
chemical_list: D007649:Ketamine