[Circling behavior produced by the unilateral intra-accumbens injection of dopaminergic agonist and two dopaminergic antagonists in mice].
Unilateral intra-accumbens injection of apomorphine, a dopaminergic agonist, produced circling contralateral to the site of injection in Balb/c mice. Unilateral intra-accumbens injection of haloperidol and metoclopramide, two dopaminergic antagonists, produced ipsilateral circling. These results support the hypothesis that the dopaminergic receptors in the nucleus accumbens also contribute to the direction of locomotor activity.
Mrabet
O
O
Laboratoire de Psychophysiologie, U.R.A.-C.N.R.S. n. 339, Université de Bordeaux-I, Talence.
Messier
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C
Destrade
C
C
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects*; D012686:Septal Nuclei / Q000187:drug effects*
D006220:Haloperidol; D008787:Metoclopramide; D001058:Apomorphine
Comportement de rotation produit par l'injection unilatérale intra-accumbens d'un agoniste et de deux antagonistes dopaminergiques chez la souris.