Two-year follow-up of changes in clinical chemistry in Singaporean Norplant acceptors: haemostatic changes.
A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant for contraceptive purposes. At the end of 2 years of use, results from this ongoing study indicate that these acceptors continue to have an increased predisposition to thrombosis as evidenced by significant increases in platelet count and aggregability. The shortened but stable prothrombin time and activated partial thromboplastin time and increase in certain coagulation factors indicate that Norplant acceptors still have a possible potential for hypercoagulation at the end of two years of use.
Singh
K
K
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Viegas
O A
OA
Koh
S
S
Singh
P
P
Ratnam
S S
SS
D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008137:Longitudinal Studies; D009644:Norgestrel / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D012846:Singapore; D013927:Thrombosis / Q000139:chemically induced*
D009644:Norgestrel; D016912:Levonorgestrel