title: Expression of raf oncogenes activates the PEA1 transcription factor motif.
abstract: PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.
authors.affiliation: Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Wasylyk
authors.forename: B
authors.initials: B
authors.lastname: Wasylyk
authors.forename: G
authors.initials: G
authors.lastname: Heidecker
authors.forename: M
authors.initials: M
authors.lastname: Huleihel
authors.forename: U R
authors.initials: UR
authors.lastname: Rapp
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA