Induction of squamous metaplasia, dysplasia and carcinoma in situ of the mouse tracheal mucosa by inhalation of sodium chloride mist following subcutaneous injection of 4-nitroquinoline 1-oxide.
Squamous metaplasia, dysplasia and carcinoma in situ (CIS) were induced in the ICR/Jcl mouse tracheal mucosa by exposure to a mist of 5% NaCl solution following single subcutaneous injection of 4-nitroquinoline 1-oxide (4-NQO). Either subcutaneous injection of 4-NQO or NaCl inhalation alone did not cause any marked change in the tracheal mucosa. The NaCl inhalation is considered to have promotion-like action on the mouse tracheal mucosa after administration of 4-NQO injection.
Karube
T
T
Department of Public Health, Saitama Medical College, Tokyo.
Katayama
H
H
Takemoto
K
K
Watanabe
S
S
D015112:4-Nitroquinoline-1-oxide / Q000008:administration & dosage / Q000633:toxicity*; D000280:Administration, Inhalation; D000818:Animals; D002278:Carcinoma in Situ / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D007279:Injections, Subcutaneous; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008679:Metaplasia; D051379:Mice; D008813:Mice, Inbred ICR; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009600:Nitroquinolines / Q000633:toxicity*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000473:pathology*; D014134:Tracheal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D009600:Nitroquinolines; D012965:Sodium Chloride; D015112:4-Nitroquinoline-1-oxide