title: Theileria parva: the immune status of calves born of dams immunised against East Coast fever.
abstract: Eight Friesian cross cows three months pregnant to a single Friesian bull were immunised against East Coast fever by infection with Theileria parva (Muguga) sporozoite stabilate and treatment with pyrrolidino-methyl tetracycline. They were challenged with the homologous stock four times before calving and a fifth time after calving, and resisted all five challenges which killed all of the five groups of five susceptible controls. Calves born to these hyperimmunised dams were fully susceptible on challenge with the same stabilate, as were susceptible cows from the same farm and their calves. In both instances the calves died three to seven days earlier than the cows which were approximately 10 times heavier. These results show that one- to two-month-old taurine calves from artificially immunised dams are not protected from experimental T parva sporozoite challenge and that there is no inherent calfhood resistance to East Coast fever.
authors.affiliation: FAO/UNDP Immunological Research on Tick-borne Diseases Project, Kikuyu, Kenya.
authors.forename: M P
authors.initials: MP
authors.lastname: Cunningham
authors.forename: C G
authors.initials: CG
authors.lastname: Brown
authors.forename: M J
authors.initials: MJ
authors.lastname: Burridge
authors.forename: S P
authors.initials: SP
authors.lastname: Morzaria
authors.forename: G M
authors.initials: GM
authors.lastname: Urquhart
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D016782:Apicomplexa / Q000276:immunology; D002417:Cattle; D005260:Female; D007112:Immunity, Maternally-Acquired; D007114:Immunization / Q000662:veterinary*; D011247:Pregnancy; D013801:Theileriasis / Q000276:immunology*; D013997:Time Factors