Ectopic pregnancy treated with trichosanthin. Clinical analysis of 71 patients.
Pathological studies on the aborted materials after the administration of trichosanthin at the end of mid-term gestation have revealed that there is an extensive coagulative necrosis of the trophoblastic tissue of the placental villi. In 1971, we first used trichosanthin successfully to treat ectopic pregnancy instead of salpingectomy. Trichosanthin was given to the patients with ectopic pregnancy who were clinically stable and had no signs of acute distress or large quantity of intraperitoneal hemorrhage. From 1971 to 1986, a total of 71 patients were treated with trichosanthin with a success rate of 85.9% and a subsequent fertility rate of 82.6%.
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D000019:Abortifacient Agents / Q000627:therapeutic use*; D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D015978:Trichosanthin / Q000627:therapeutic use*
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D015978:Trichosanthin