title: 24 h-kinetics of iodide uptake in amiodarone induced hypothyroidism.
abstract: Amiodarone induced hypothyroidism (AIH) is assumed to result from a failure of the thyroid to escape from the inhibitory effect of inorganic iodine on its organification as a consequence of uninhibited iodide trapping. This hypothesis was supported by the 24h kinetics of radioiodine uptake in a patient with AIH. 131I uptake reached a maximum after 2h and remained unchanged from 2h to 24h. 131I uptake was in the normal range from 1 1/2h to 7h and clearly subnormal after 9h. The normal early 131I uptake was due to the non inhibition of the iodide-concentrating mechanism and the low 24h radioactivity to the decreased iodide organification. These findings presumably explain the mechanism of AIH.
authors.affiliation: Department of Endocrinology, Erasme Hospital, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Unger
authors.forename: D W
authors.initials: DW
authors.lastname: Surmont
authors.forename: J
authors.initials: J
authors.lastname: Sarot
authors.forename: A
authors.initials: A
authors.lastname: Soupart
authors.forename: J E
authors.initials: JE
authors.lastname: Dumont
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D001693:Biological Transport, Active; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D007454:Iodides / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007700:Kinetics; D013961:Thyroid Gland / Q000378:metabolism
chemical_list: D007454:Iodides; D007457:Iodine Radioisotopes; D000638:Amiodarone