In vitro activity of ampicillin/sulbactam against enterococci determined by the time-kill method.
Time-kill studies demonstrated that at clinically achievable serum concentrations, ampicillin/sulbactam was equivalent in activity to ampicillin alone against non-beta-lactamase producing isolates of Enterococcus faecalis and Enterococcus faecium. Sulbactam possessed no antibacterial activity against these organisms. It is not yet known if the activity of ampicillin will be increased with the addition of sulbactam when tested against beta-lactamase-producing enterococci.
D'Amato
R F
RF
Department of Pathology, Catholic Medical Center of Brooklyn and Queens, Inc., Jamaica, New York 11432.
Mathew
A
A
Hochstein
L
L
Cleri
D J
DJ
Johnson
J
J
D000667:Ampicillin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development; D013407:Sulbactam / Q000494:pharmacology*
C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam