title: Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes.
abstract: Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.
authors.affiliation: Institute of Pharmacological Sciences, Univ. of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marinovich
authors.forename: L M
authors.initials: LM
authors.lastname: Flaminio
authors.forename: M
authors.initials: M
authors.lastname: Papagni
authors.forename: C L
authors.initials: CL
authors.lastname: Galli
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D011464:Epoprostenol / Q000096:biosynthesis; D007213:Indomethacin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis
chemical_list: D001095:Arachidonic Acids; D016718:Arachidonic Acid; D013929:Thromboxane B2; D002251:Carbon Tetrachloride; D011464:Epoprostenol; D001219:Aspartate Aminotransferases; D015232:Dinoprostone; D007213:Indomethacin