Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks.
Human apolipoprotein E exhibits genetic polymorphism in all populations examined to date. By isoelectric focusing and immunoblotting, three common alleles have been demonstrated in 365 unrelated Nigerian blacks. Furthermore, the APO E genetic polymorphism's effect on quantitative levels of lipids and lipoproteins has been determined. The respective frequencies of the APO E*2, APO E*3, and APO E*4 alleles are .027, .677, and .296. The effect of APO E polymorphism is significant only on total cholesterol and low-density lipoprotein cholesterol. The average excesses of the APO E*2 allele are to lower total cholesterol and low-density lipoprotein cholesterol by 9.19 mg/dl and 11.11 mg/dl, respectively. The average excesses of the APO E*4 allele are to increase total cholesterol and low-density lipoprotein cholesterol by 5.64 mg/dl and 6.18 mg/dl, respectively. On the basis of the differences in (a) the distribution of APO E allele frequencies between the Nigerians and other populations and (b) dietary lipids, we propose a model that shows that lipid metabolism is influenced by the combined effects of the APO E polymorphism and environmental factors.
Sepehrnia
B
B
Human Genetics Division, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Kamboh
M I
MI
Adams-Campbell
L L
LL
Bunker
C H
CH
Nwankwo
M
M
Majumder
P P
PP
Ferrell
R E
RE
D000483:Alleles; D001053:Apolipoproteins / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009549:Nigeria; D010641:Phenotype; D011110:Polymorphism, Genetic; D012727:Sex Characteristics
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D008074:Lipoproteins