title: Nucleolar organizing regions in renal cell carcinoma, renal oncocytoma and renal adenoma.
abstract: Nucleolar organizing regions (NORs), as demonstrated by the silver-colloid staining technique, have been counted in 75 renal cell carcinomas (20 grade 1, 22 grade 2, 17 grade 3 and 16 sarcomatoid), eight renal oncocytomas and nine renal adenomas. Mean NOR counts were 3.27, 6.28, 9.24 and 8.12, respectively, for grades 1, 2, 3 and sarcomatoid tumours, 3.09 for renal oncocytomas and 2.63 for renal adenomas. Analysis of data using the unpaired Student's t-test showed significant difference between NOR counts of grade 1, 2 and 3/sarcomatoid renal cell carcinoma, and grades 2, 3 and sarcomatoid renal cell carcinomas when compared to renal oncocytomas and adenomas. The association between type and grade of tumour, NOR value and tumour proliferation is discussed.
authors.affiliation: Department of Pathology, Wellington School of Medicine, New Zealand.
authors.forename: B
authors.initials: B
authors.lastname: Delahunt
authors.forename: J N
authors.initials: JN
authors.lastname: Nacey
authors.forename: G D
authors.initials: GD
authors.lastname: Hammett
authors.forename: W J
authors.initials: WJ
authors.lastname: Frater
mesh_terms: D000236:Adenoma / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*