Non-von Recklinghausen's neurofibromatosis resembling a giant pigmented nevus.
We report the case of a 30-year-old female patient with non-von Recklinghausen's neurofibromatosis. In our opinion it does not fit within a system of classification recently described. Clinically, the abnormality resembled a giant pigmented nevus; however, light- and electron microscopy findings were consistent with those of a neurofibroma. No other symptoms of classic neurofibromatosis or other diseases were present. The family history showed no evidence of neurofibromatosis. To the best of our knowledge this manifestation of non-von Recklinghausen's neurofibromatosis has not been previously described. The cause and the inheritance pattern of this variant are not clear.
Bousema
M T
MT
Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.
Vuzevski
V D
VD
Oranje
A P
AP
Heule
F
F
Stolz
E
E
van Joost
T
T
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009456:Neurofibromatosis 1 / Q000145:classification / Q000473:pathology*; D009508:Nevus, Pigmented / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*