[Dynamics of early morphologic shifts in the bronchopulmonary system in intranasal infection of mice with streptococcus group B].
When mice are intranasally infected with avirulent and virulent B streptococci, one may single out 2 phases of microbe interaction with bronchopulmonary tissue: 1) streptococcal adhesion, epithelial detachment and causative agent phagocytosis occur within the first 2 hours; 2) hematogenic phagocytes are involved in the process 5 or more hours later. Unlike avirulent streptococci, virulent ones frequently lead to the formation of destructive foci and are less actively phagocytized. On infection with avirulent strain, the microbes seed from the lung during 24 hours. The phagocytotic index and mean alveolar macrophage destruction values are in excess of the similar values seen in polymorphonuclear leukocytes, becoming lower on day 6 of postinfection.
Bartazarian
N D
ND
Chloian
A E
AE
Khostikian
N G
NG
Grabovskaia
K B
KB
Bulgakova
T N
TN
D000262:Adenylyl Cyclases / Q000378:metabolism; D000281:Administration, Intranasal; D000818:Animals; D001980:Bronchi / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008264:Macrophages; D051379:Mice; D009504:Neutrophils; D010587:Phagocytosis; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013290:Streptococcal Infections / Q000201:enzymology / Q000473:pathology*; D013292:Streptococcus agalactiae; D013997:Time Factors
D011451:Prostaglandin-Endoperoxide Synthases; D000262:Adenylyl Cyclases
Dinamika rannykh morfologicheskikh sdvigov v bronkholegochnoĭ sisteme pri intranazal'nom zarazhenii mysheĭ streptokokkom gruppy B.