title: Exogenous glycosaminoglycans modulate extracellular and intracellular accumulation of newly synthesized glycosaminoglycans by embryonic chick skin fibroblasts.
abstract: The effects of exogenous glycosaminoglycans (GAG) on newly synthesized GAG accumulation in intra- and extra-cellular compartments of 17 incubation days chick embryonic skin fibroblasts have been examined. Exogenous GAG are able to act on both total GAG synthesis and secretion by embryonic fibroblasts and on the relative concentration of individual GAG. A decline in hyaluronic acid and an increase in chondroitin sulfate plus dermatan sulfate in the cellular compartment for all GAG administered have been detected. There was also similar behaviour in the extracellular compartment after sulfated GAG administration.
authors.affiliation: Institute of Histology, University of Ferrara, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Evangelisti
authors.forename: G
authors.initials: G
authors.lastname: Stabellini
authors.forename: E
authors.initials: E
authors.lastname: Becchetti
authors.forename: P
authors.initials: P
authors.lastname: Carinci
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002809:Chondroitin Sulfates / Q000378:metabolism; D003871:Dermatan Sulfate / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism; D012867:Skin / Q000166:cytology* / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D003871:Dermatan Sulfate; D006820:Hyaluronic Acid; D006493:Heparin; D002809:Chondroitin Sulfates