A histopathological and morphometrical study of femur head cartilage in Wistar rats treated with prednisolone.
An analysis was made of histopathological developments in femur head cartilage in a group of Wistar rats receiving a daily intra-muscular injection of 2.5 mg prednisolone. This group was divided into four experimental batches, each consisting of 6 rats. Batches were sacrificed at 15, 30, 60 and 90 days after the start of the experiment. Degeneration of the femur head cartilage was observed from the start of the experiment (15 days), and gave rise to chondrocyte necrosis by 90 days. Structural modifications are shown morphologically and morphometrically.
Barrueco
J L
JL
Department of Traumatology, San Pedro de Alcántara General Hospital, Cáceres, Spain.
Gázquez
A
A
Redondo
E
E
Roncero
V
V
Durán
E
E
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D005270:Femur Head / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
D011239:Prednisolone