title: Antitumor effect of K18 on metastatic models.
abstract: K18 is a newly synthesized antitumor agent which is the conjugate form of human immunoglobulin with p-di (2-chloroethyl)-amino-L-phenylalamine (melphalan). The antitumor effect of K18 on two animal metastatic models was investigated: (a) Lewis lung carcinoma was transplanted into thigh muscle of mice, followed by the reaction of the primary lesion, or the tumor was transplanted through the tail vein: (b) a renal model was also created, where colon-26 was inoculated into the renal capsule of BALB/c mice. Oral administration of K18 resulted in the decrease in the number of nodules in the lung in the case of tumor transplantation through tail vein.
authors.affiliation: Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Furusho
authors.forename: K
authors.initials: K
authors.lastname: Niimura
authors.forename: N
authors.initials: N
authors.lastname: Sugita
authors.forename: Y
authors.initials: Y
authors.lastname: Oguchi
authors.forename: K
authors.initials: K
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Iijima
authors.forename: M
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins; D000922:Immunotoxins / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008558:Melphalan / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D005719:gamma-Globulins / Q000627:therapeutic use*
chemical_list: D007136:Immunoglobulins; D000922:Immunotoxins; C045927:K-18 conjugate; D005719:gamma-Globulins; D008558:Melphalan