title: Neuroimaging in patients with seizures of probable frontal lobe origin.
abstract: Twenty-two patients whose electroclinical ictal characteristics suggested frontal lobe seizure foci were studied. Computed tomography (CT) scans showed abnormalities in only 32% of patients whereas magnetic resonance imaging was informative in 45%. 18FDG-Positron emission tomography (PET) scanning revealed decreased metabolism in 64% of the group. The areas of hypometabolism were focal, regional, or hemispheric. Focal frontal hypometabolism was significantly correlated with the electroclinical (semiologic) ictal localization. Therefore, FDG-PET scanning is a sensitive and specific technique for investigating patients with seizures of probable frontal lobe origins.
authors.affiliation: VA Southwest Regional Program, West Los Angeles VA Medical Center (Wadsworth), CA 90073.
authors.forename: B E
authors.initials: BE
authors.lastname: Swartz
authors.forename: E
authors.initials: E
authors.lastname: Halgren
authors.forename: A V
authors.initials: AV
authors.lastname: Delgado-Escueta
authors.forename: M
authors.initials: M
authors.lastname: Mandelkern
authors.forename: M
authors.initials: M
authors.lastname: Gee
authors.forename: N
authors.initials: N
authors.lastname: Quinones
authors.forename: W H
authors.initials: WH
authors.lastname: Blahd
authors.forename: J
authors.initials: J
authors.lastname: Repchan
mesh_terms: D003847:Deoxyglucose / Q000031:analogs & derivatives; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013690:Television; D013702:Temporal Lobe / Q000473:pathology; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose