The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume.
Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.
Eden
J A
JA
Department of Gynecology, Charing Cross Hospital, London, United Kingdom.
Place
J
J
Carter
G D
GD
Jones
J
J
Alaghband-Zadeh
J
J
Pawson
M E
ME
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004717:Endometrium / Q000187:drug effects*; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase / Q000187:drug effects*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D014599:Uterus / Q000187:drug effects*
D004967:Estrogens; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone