Antimutagenic effect of garlic (Allium sativum L.) on 4NQO-induced mutagenesis in Escherichia coli WP2.
Aqueous extract prepared from garlic bulbs markedly suppressed the mutagenesis in both E. coli WP2 trp- and E. coli WP2 trp- uvrA- induced by 4-nitroquinoline 1-oxide (4NQO), but not that induced by UV. Cellular toxicity, inhibition of the expression of the Trp+ phenotype and delay of the first cell division after 4NQO treatment were not observed in the presence of the extract. Since the extract showed identical antimutagenic effects against 4NQO in both test strains but no effect on the mutagenesis of UV, it seems that the extract might act by inactivating the electrophilic group(s) of 4NQO or inhibiting its metabolic activation.
Zhang
Y S
YS
Department of Pathophysiology, Zhejiang Medical University, Hangzhou, China.
Chen
X R
XR
Yu
Y N
YN
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004926:Escherichia coli / Q000235:genetics; D005737:Garlic; D009152:Mutagenicity Tests; D009154:Mutation; D009600:Nitroquinolines / Q000494:pharmacology*; D010936:Plant Extracts; D010946:Plants, Medicinal
D009600:Nitroquinolines; D010936:Plant Extracts; D015112:4-Nitroquinoline-1-oxide