Role of gonadotropin releasing hormone agonists in ovulation induction.
The use of exogenous gonadotropins for ovulation induction in anovulatory women or for superovulation in gamete intrafallopian transfer or in vitro fertilization is complicated by premature luteinization, multiple gestation and ovarian hyperstimulation. Desensitization of the pituitary gonadotrophs can be achieved with gonadotropin releasing hormone (GnRH) agonists. The adjunctive use of GnRH agonists with exogenous gonadotropins prevents premature luteinization, possibly resulting in an improvement in ovarian stimulation.
Dodson
W C
WC
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.
D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D010906:Pituitary Hormone-Releasing Hormones / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy
D010906:Pituitary Hormone-Releasing Hormones; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide