Prostaglandin endoperoxide synthase contains an EGF-like domain.
Prostaglandin endoperoxide synthase was subjected to the computer-assisted homology search in the protein primary structure database, in order to investigate the regulation mechanism of the expression of prostaglandin endoperoxide synthase. As a result of that, it turned out that prostaglandin endoperoxide synthase shares sequence homology with epidermal growth factor (EGF) in the N-terminal region. The implication of the existence of an EGF-like domain in prostaglandin endoperoxide synthase is discussed.
Toh
H
H
Protein Engineering Research Institute, Osaka, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004815:Epidermal Growth Factor / Q000235:genetics*; D006801:Humans; D007256:Information Systems; D051379:Mice; D008969:Molecular Sequence Data; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D012756:Sheep
D004815:Epidermal Growth Factor; D011451:Prostaglandin-Endoperoxide Synthases