title: Airway insufflation: physiologic effects on acute and chronic gas exchange in humans.
abstract: Reduction in dead space through conventional tracheostomy has been used to treat patients with chronic CO2 retention. The insufflation of air directly into the trachea by transtracheal catheter (airway insufflation, AI) provides reductions in dead space as great or greater than those of tracheostomy. The physiologic effects of AI on gas exchange have not been adequately studied because instillation of gases into the trachea contaminates minute ventilation (VL), dead space volume (VD), tidal volume (VT), and other indices of gas exchange, as measured by usual technics. We overcame this problem by devising special methods of measuring inspired and expired ventilation, alveolar and dead space ventilation, and VT and VD by using pneumotachographic timing of inspiration and expiration so that true inspired and expired ventilation were calculated. We studied 5 patients with chronic CO2 retention from either COPD, scoliosis, or muscular dystrophy (annual average PaCO2 = 45 to 75 mm Hg) during 75 min of AI with serial gas exchange and arterial blood gas measurements. AI at about 5 L/min of room air through the trachea in 5 patients reduced VL by 18% (from 7.91 to 6.48 L/min), VT by 25% (from 450 to 338 ml), and VD by 37% (from 223 to 141 ml), while not affecting PaCO2 (from 51.8 to 48.2 mm Hg) or PaO2 (from 65.1 to 63.4 mm Hg). In 2 patients, AI administered continuously for 4 to 12 months (as 30 to 50% O2) maintained PaCO2 as well as or better than breathing enriched O2 from a tracheal collar via an open tracheostomy.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, State University of New York, Stony Brook.
authors.forename: E H
authors.initials: EH
authors.lastname: Bergofsky
authors.forename: A N
authors.initials: AN
authors.lastname: Hurewitz
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology / Q000628:therapy; D007327:Insufflation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis / Q000097:blood; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology; D012126:Respiratory Dead Space / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D013147:Spirometry / Q000379:methods; D013990:Tidal Volume / Q000502:physiology; D014132:Trachea
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen