Review article: a role for gastrointestinal prokinetic agents in the treatment of reflux oesophagitis?
Gastro-oesophageal reflux disease may result from a host of factors. Medical therapy has largely been aimed at neutralizing acid or decreasing acid production but improvement of upper-gastrointestinal motility may prove to be a valuable treatment modality as well. This paper reviews the current state of knowledge of the pathogenesis of reflux disease and concentrates upon promotility treatment with domperidone, metoclopramide and cisapride.
Verlinden
M
M
Department of Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium.
D000818:Animals; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans
D005765:Gastrointestinal Agents