Binucleated neurons in the human brain.
We found binucleated neurons in 8 autopsied brains and one surgical specimen with the numbers varying from one to several. All were found in the brain stem, mostly in the pons, next in the thalamus, and the least in the mid-brain and medulla. None was found in the cerebrum and cerebellum. The ages of the patients varied from 24 days postpartum to 74 years. More binucleated neurons were found in new born babies. The patients suffered from various disease which might be related to ischemic state of the brain. The binucleated neurons might be an abortive hyperplasia of the nerve cells reacting to unfavorable circumstances. According to our observations, binucleated neurons are not very rare.
Zang
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D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002455:Cell Division; D002467:Cell Nucleus / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D011149:Pons / Q000473:pathology