title: Primary plasma cell leukemia: a case report of successful responder to a combination chemotherapy of vincristine, doxorubicin and dexamethasone.
abstract: A patient with primary plasma cell leukemia is described. Immunoelectrophoresis revealed a monoclonal IgG/lambda protein and Bence Jones protein. Hematological data showed numerous immature plasma cells in peripheral blood and bone marrow. Cytogenetic study of tumor cells revealed a complex karyotypic abnormality. Subcutaneous involvement by tumor cells was found. The patient was treated with a combination of vincristine, doxorubicin, dexamethasone (VAD) and achieved a complete remission with disappearance of tumor cells, monoclonal protein and extramedullary involvement after 6 cycles of VAD. This regimen should be encouraged in treatment of primary plasma cell leukemia.
authors.affiliation: Department of Internal Medicine, Tokyo Women's Medical College Daini Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kawauchi
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: M
authors.initials: M
authors.lastname: Yasuyama
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin