Immunoglobulin G subclass deficiency and susceptibility to pyogenic infections in patients with AIDS-related complex and AIDS.
Total immunoglobulin (Ig) and IgG subclass levels were measured in 72 patients with AIDS or AIDS-related complex (ARC). IgG2 subclass levels were found to be significantly decreased in the AIDS/ARC patients with pyogenic infections compared with both similar individuals without bacterial disease and the HIV-negative control group.
Parkin
J M
JM
Department of Immunology, St Mary's Hospital and Medical School, London, UK.
Helbert
M
M
Hughes
C L
CL
Pinching
A J
AJ
D000386:AIDS-Related Complex / Q000150:complications / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D004198:Disease Susceptibility; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology*; D006801:Humans; D017099:IgG Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male
D007070:Immunoglobulin A; D007075:Immunoglobulin M