[Elimination of disorders in the electrical stability of the heart during postinfarct cardiosclerosis by using a factor that induces GABA accumulation in the brain].
It was shown that disturbances of the heart electrical stability in postinfarction cardiosclerosis manifested in a fall of the electrical threshold of the heart fibrillation and the development of extrasystoles during the vagus stimulation. These disturbances were effectively eliminated by administration of GABA in the brain.
Abdikaliev
N A
NA
Shabunina
E V
EV
Meerson
F Z
FZ
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012598:Sclerosis; D014635:Valproic Acid / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid
Ustranenie narusheniĭ élektricheskoĭ stabil'nosti serdtsa pri postinfarktnom kardioskleroze s pomoshch'iu faktora, vyzyvaiushchego nakoplenie GAMK v golovnom mozge.