[Various immune functions (with particular attention to NK cells) in young people with frequent episodes of pharyngitis].
In four girls, selected during three years of ambulatory observations, the evolution of repeated upper respiratory tract infection events, under the immunologic aspect, has been studied. The group of girls, with age between 13 and 16 years, practically formed a small casuistry, as an experimental recruitment. With the aim to find the causes of the told infectious events, firstly were checked numerous immune functions, successively were evaluated only the ones that had resulted altered (percentage number of "NK" cells, complement "C3" fraction and "T4" lymphocytes). Particularly significative variations, toward diminution, of the "NK" cells number related to the most compelling school attendance periods were recognized. What observed could let hypothesize that stress and emotions , correlated to scholastic events negatively influence some immune functions, peculiarly the number of "NK" cells. To the lowering of these cells could correspond a facilitation and higher frequency of upper respiratory tract infections (with pharynx as an epicenter), likely by viral aetiology. The subsequent vicarious and/or compensatory intervention by other immune functions could allow, however, the spontaneous recovery, without chemotherapeutic recourse, of the infectious events, that could arise with higher frequency but, most likely, with lower seriousness than could happen when "NK" cells normally act.
Rosaschino
F
F
Ist. di Pediatria dell'Università di Milano.
Albertini
A
A
Torre
R
R
Noseda
F
F
D000293:Adolescent; D003176:Complement C3 / Q000032:analysis; D004198:Disease Susceptibility / Q000276:immunology*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D010612:Pharyngitis / Q000209:etiology / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology*; D013315:Stress, Psychological / Q000150:complications*; D013334:Students / Q000523:psychology; D016176:T-Lymphocyte Subsets
D003176:Complement C3
Studio di alcune funzioni immunitarie (con particolare attenzione alle cellule "NK") in giovani con frequenti episodi faringitici.