title: A new antitumor antibiotic, FR900840. II. Structural elucidation of FR900840.
abstract: The structure of FR900840, a new antitumor antibiotic produced by a strain of Streptomyces has been deduced as 1 on the basis of spectroscopic and chemical evidence and finally confirmed by synthesis from L-threonine and L-serine.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Nakada
authors.forename: S
authors.initials: S
authors.lastname: Takase
authors.forename: A
authors.initials: A
authors.lastname: Katayama
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006865:Hydrogenation; D006868:Hydrolysis; D006885:Hydroxybutyrates / Q000032:analysis / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012694:Serine / Q000031:analogs & derivatives / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces; D013912:Threonine / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D006885:Hydroxybutyrates; C058022:thrazarine; D013912:Threonine; D012694:Serine