title: [In vitro activity of clofazimine alone and in combination with amikacin, roxithromycin, rifampicin and rifapentine against Mycobacterium avium-intracellulare].
abstract: The activity of clofazimine, amikacin, roxithromycin, rifampicin and rifapentine was tested, alone and in association, against Mycobacterium avium intracellulare. Clofazimine, amikacin and rifapentine were shown to be very active. With all established associations, the MIC observed for each drug alone was appreciably reduced.
authors.forename: M
authors.initials: M
authors.lastname: Casal Román
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez López
authors.forename: R
authors.initials: R
authors.lastname: Villalba Montoro
authors.forename: A I
authors.initials: AI
authors.lastname: González Requero
mesh_terms: D000583:Amikacin / Q000494:pharmacology*; D002991:Clofazimine / Q000494:pharmacology*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015575:Roxithromycin / Q000494:pharmacology*
chemical_list: D015575:Roxithromycin; D000583:Amikacin; D002991:Clofazimine; D012293:Rifampin; C018421:rifapentine
vernacular_title: Actividad in vitro de clofacimina aisladamente y en asociación con amikacina, roxitromicina, rifampicina y rifapentina frente a Mycobacterium avium-intracellulare.