[Inhibition of prednisolone osteopathy by diphosphonate (EHDP) in an animal experiment].
The application of a low dose of prednisolone (0.4 mg per kg body weigh and day) in young hamsters leads to a loss of bone mass. This effect is inhibited by the administration of the diphosphonate EHDP (6.2 mg per kg body weight and day). The total volume of the limb bones is increased. The application of a high dose of prednisolone (40 mg per kg body weight and day) induces a severe osteopathy. These pathological bone changes couldn't be prevented by EHDP, but there was a significant shift of the investigated parameters into the direction of normalization.
Trzenschik
K
K
Lindenhayn
K
K
Bühler
G
G
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D006224:Cricetinae; D012968:Etidronic Acid / Q000008:administration & dosage*; D008297:Male; D008647:Mesocricetus; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control; D011239:Prednisolone / Q000633:toxicity*
D011239:Prednisolone; D012968:Etidronic Acid
Inhibierung der Prednisolon-Osteopathie durch Diphosphonat (EHDP) im Tierexperiment.