title: Postischaemic interrelations between energy metabolism and functional recovery of protected canine kidneys.
abstract: Following renal ischaemia under effective protection glomerular filtration starts at a time when renal high-energy phosphates are resynthesized. The present investigation was carried out to examine the interdependence of the two processes. Therefore, canine kidneys were protected with sodium poor and nominally Ca2+ free buffered solutions. After different times of ischaemia and reperfusion the glomerular filtration rates (GFR) were determined and afterwards tissue specimens were excised for the determination of high-energy phosphates. Both the GFR and the renal energy content were higher with shorter ischaemia periods or longer reperfusion. As a rule there was a correlation between GFR and ATP, both probably mainly signifying the degree of preservation of proximal nephron sites, as the interrelation between the GFR and the renal SAN (ATP + ADP + AMP) content also signifies. However, with the addition of aspartate to the protective solution it could be demonstrated that the GFR also can rise without a concomitant increase of ATP. Under certain conditions an increase of GFR can even be associated with a lowering of the renal ATP content.
authors.affiliation: Department of Physiology and Pathophysiology, University of Göttingen, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Kehrer
authors.forename: M
authors.initials: M
authors.lastname: Blech
authors.forename: M
authors.initials: M
authors.lastname: Kallerhoff
authors.forename: M
authors.initials: M
authors.lastname: Langheinrich
authors.forename: H J
authors.initials: HJ
authors.lastname: Bretschneider
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004285:Dogs; D004734:Energy Metabolism; D005919:Glomerular Filtration Rate; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D010477:Perfusion; D015424:Reperfusion
chemical_list: D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate