[Adenosine deaminase in pleural effusions. Its usefulness in the diagnosis of tuberculous pleurisy].
The activity of adenosine deaminase was determined in 79 pleural effusions in order to evaluate the utility and reliability in diagnosing tuberculous effusions. The effusions were grouped by the etiology: 26 were tuberculous (group I); 22 were neoplastic (group II); 11 were pneumonic (group III); 10 were non-infections exudates of different causes (group IV); and 10 transudates (group V). Group I presented the higher median value of AD (MED = 81.92; DE: 29.02) the difference being statistically significant (p less than 0.0001) compared with the results of the other groups. We found 2 cases of pleural tuberculosis histologically demonstrated with AD levels under the amount of 40 U/L. In our experience, AD determination had a sensitivity of 92% and specificity of 94%; with a predictive value of 89% and a negative predictive value of 96%, this being considered useful but non specific of tuberculosis.
Pérez de Oteyza
C
C
Chantres
M T
MT
Rebollar
J L
JL
Muñoz Yañez
M C
MC
García Marcos
F
F
Pérez Barba
M
M
Enríquez de Salamanca
R
R
D000243:Adenosine Deaminase / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010996:Pleural Effusion / Q000201:enzymology* / Q000209:etiology; D011014:Pneumonia / Q000150:complications; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014396:Tuberculosis, Pleural / Q000150:complications / Q000175:diagnosis*
D000243:Adenosine Deaminase
Adenosina desaminasa (ADA) en los derrames pleurales. Su utilidad en el diagnóstico de la pleuresia tuberculosa.