[Deposition of light chains in various organs; light chain deposition disease].
The case is reported of a patient with renal insufficiency, proteinuria and heart failure caused by 'light chain deposition disease' (LCDD). A renal biopsy showed nodular glomerulosclerosis, IF examination revealed linear deposits of monoclonal lambda light chains along the glomerular and tubular basement membranes. Similar deposits could be shown in a skin biopsy. No light chains could be detected in urine and serum. The patient had a good response to treatment with melphalan and prednisone.
van Klaveren
R J
RJ
Holdrinet
R S
RS
Assmann
K J
KJ
D058186:Acute Kidney Injury / Q000150:complications*; D000368:Aged; D005455:Fluorescent Antibody Technique; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D010265:Paraproteinemias / Q000150:complications*
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains
Neerslag van lichte ketens in verscheidene organen; 'light chain deposition disease'.