Reversal of dopamine extravasation injury with topical nitroglycerin ointment.
We treated a neonate with two sites of ischemia caused by dopamine extravasation. Standard treatment called for local infiltration of phentolamine, an alpha blocker. Instead, we applied 2% topical nitroglycerin ointment and the ischemia was totally reversed.
Denkler
K A
KA
Division of Plastic Surgery, St. Joseph Hospital, Greenbrae, Calif.
Cohen
B E
BE
D000287:Administration, Topical; D004298:Dopamine / Q000009:adverse effects* / Q000627:therapeutic use; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007511:Ischemia / Q000139:chemically induced*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000098:blood supply*
D005996:Nitroglycerin; D004298:Dopamine