Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.
Shepherd
J C
JC
Biozentrum, University of Basel, Switzerland.
Walldorf
U
U
Hug
P
P
Gehring
W J
WJ
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D015977:Eukaryotic Initiation Factor-1 / Q000235:genetics*; D008136:Longevity; D008297:Male; D009154:Mutation; D010957:Plasmids; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D015977:Eukaryotic Initiation Factor-1; D012333:RNA, Messenger