Serotonin and treatment in obsessive-compulsive disorder.
Recognized since the Middle Ages, and clearly described for more than 100 years, obsessive-compulsive disorder (OCD) continues to intrigue and challenge mental health professionals. Recent evidence has implicated dysfunctional serotonergic neurotransmission in OCD. This review summarizes the evidence favoring a serotonergic hypothesis for OCD followed by a more detailed discussion of the implications the hypothesis holds for treatment.
March
J S
JS
Department of Psychiatry, University of Wisconsin Hospital, Madison 53792.
Gutzman
L D
LD
Jefferson
J W
JW
Greist
J H
JH
D001521:Behavior Therapy; D002997:Clomipramine / Q000627:therapeutic use; D016666:Fluvoxamine; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism / Q000628:therapy*; D010091:Oximes / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D010091:Oximes; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D002997:Clomipramine; D016666:Fluvoxamine