[Studies on the immunoregulative action of polysaccharides isolated from hyphal bodies of Lentinnus edodes (PHL) on hypoimmunity in mice].
PHL possesses significant antagonist action for immunodepression in mice induced by different immunodepressors. It can reverse the hypomacrophage function and the reduction in percentage of T-lymphoid cell induced by hydrocortisone (50 or 80 mg/kg, sc), reverse the reduction of phagocytosis of reticuloendothelial system (RES) induced by hydroprednisone acetate (20 and 40 mg/kg, ip), restore the cyclophosphamide-suppressed delayed anaphylaxis reaction in mice (40 and 80 mg/kg, ip). In vitro PHL at a dose of 1 and 10 micrograms/ml accelerated lymphocyte mitosis induced by conA and PHA.
Zeng
X Y
XY
Li
Y D
YD
Chen
L L
LL
He
F
F
D000818:Animals; D001487:Basidiomycota; D002606:Charcoal / Q000493:pharmacokinetics; D006968:Hypersensitivity, Delayed / Q000628:therapy; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008811:Mice, Inbred DBA; D010587:Phagocytosis; D011134:Polysaccharides / Q000494:pharmacology*
D011134:Polysaccharides; D002606:Charcoal