The influence of dietary calcium reduction on aluminum absorption and kinetics in the rabbit.
There is considerable evidence of an aluminum (Al)-calcium (Ca) interaction, including potentiation of Al accumulation and toxicity by Ca deficiency. To elucidate the influence of dietary Ca on Al absorption, rabbits were maintained on a low-Ca (0.024%) or a Ca-replete (0.83%) diet for 2 wk prior to testing. Once weekly, Al hydroxide, nitrate, citrate, or lactate or sucralfate was given orally, or Al lactate was given intravenously (iv). Oral Al bioavailability was determined by comparison of the area under the Al concentration-time curve to that obtained after iv Al. Neither oral Al bioavailability nor the pharmacokinetic parameters of iv Al lactate was significantly affected by dietary Ca concentration. When measured before the weekly Al treatments, total serum Ca of rabbits fed the low-Ca diet averaged 88% of rabbits fed the Ca-replete diet. Total serum Ca 1-72 h after Al treatment decreased from 1% (Al hydroxide) to 15% (Al citrate) below pretreatment concentrations.
Yokel
R A
RA
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
McNamara
P J
PJ
D000284:Administration, Oral; D000535:Aluminum / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000172:deficiency; D002136:Calcium, Dietary / Q000494:pharmacology*; D004032:Diet; D005260:Female; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D011817:Rabbits
D002136:Calcium, Dietary; D000535:Aluminum; D002118:Calcium