Myelofibrosis with myeloid metaplasia following essential thrombocythaemia.
We report a male patient in whom a diagnosis of essential thrombocythaemia was made at the age of 25. The clinical course was characterised by recurrent thrombotic episodes during the first few years of the disease, followed by a relatively benign course. He was treated with 32P, nitrogen mustard and plateletpheresis. A transformation into myelofibrosis with myeloid metaplasia was revealed 20 years after ET diagnosis. The length of the disease and the 32P therapy are discussed as factors favouring this metamorphosis.
Liberato
N L
NL
Dipartimento di Medicina Internae e Terapia Medica, Sezione Clinica Medica II, IRCCS Policlinico S. Matteo, Pavia, Italia.
Barosi
G
G
Costa
A
A
D'Elia
P
P
Boccaccio
P
P
D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000209:etiology*; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000628:therapy; D013997:Time Factors