[Mutant Bac. subtilis A2 with an enhanced capacity to induce an adaptive response].
Mutant A2 with increased ability to induce adaptive response was isolated in Bac. subtilis and its properties studied. Mutant A2 was shown to be more resistant to mutagenic action of MNNG, EMS, UV light. It was also discovered that A2 was more sensitive to the lethal action of MNNG and UV light than parent strain 103. It was shown by clonal analysis of mutant colonies, formed by mutant cells A2 and 103 that A2 strain had increased ability to form complete mutants. Properties of A2 mutant suggest that in the process adaptive response induction were is expression of both adaptive response enzymes and some other which are necessary for reparation of premutagenic UV lesions.
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D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D008769:Methylnitronitrosoguanidine; D005020:Ethyl Methanesulfonate; D008741:Methyl Methanesulfonate
Mutant Bac. subtilis A2 s povyshennoĭ sposobnost'iu k induktsii adaptivnogo otveta.