title: Sebaceous carcinoma. Diuretic use, lacrimal system spread, and surgical margins.
abstract: Twenty cases of adnexal sebaceous carcinoma managed by contemporary methods, including monitoring of surgical margins, were reviewed. Eight of 20 patients were taking diuretic medications. The initial clinical diagnosis was incorrect in all cases, and 50% of cases were misdiagnosed by the pathologist interpreting the initial biopsy. The canaliculus was identified in 7 cases, and was involved by tumor in 3 cases. Tumor was identified in the lacrimal sac and inferior turbinate in an additional case. Thus, tumor spread into the lacrimal excretory system was documented by histologic findings in 4 cases.
authors.affiliation: Kansas University Medical Center, Department of Ophthalmology, Kansas City 66103.
authors.forename: J A
authors.initials: JA
authors.lastname: Khan
authors.forename: A S
authors.initials: AS
authors.lastname: Grove
authors.forename: M P
authors.initials: MP
authors.lastname: Joseph
authors.forename: M
authors.initials: M
authors.lastname: Goodman
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003937:Diagnosis, Differential; D004232:Diuretics / Q000008:administration & dosage*; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors
chemical_list: D004232:Diuretics