title: A case of diffuse panbronchiolitis (DPB) with benign monoclonal IgA gammopathy and IgA nephropathy with monoclonal IgA deposition.
abstract: A case of diffuse panbronchiolitis (DPB), associated with benign monoclonal IgA gammopathy and IgA nephropathy is described. The IgA deposition in the glomeruli of the patient was identified as consisting mainly of the monoclonal IgA having the same idiotype as that of serum monoclonal IgA. Recurrent infections of Hemophilus influenzae and Pseudomonas aeruginosa in the respiratory tract might have enhanced IgA-mediated immunity at the mucosal surface of the bronchiole, and ultimately induced monoclonal IgA gammopathy and IgA nephropathy.
authors.affiliation: First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Kida
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Koshino
authors.forename: N
authors.initials: N
authors.lastname: Tomosugi
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001988:Bronchiolitis / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D007070:Immunoglobulin A / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008297:Male; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D014973:Xanthomatosis / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains