Expression of raf oncogenes activates the PEA1 transcription factor motif.
PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.
Wasylyk
C
C
Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Strasbourg, France.
Wasylyk
B
B
Heidecker
G
G
Huleihel
M
M
Rapp
U R
UR
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA