title: [Deposition of light chains in various organs; light chain deposition disease].
abstract: The case is reported of a patient with renal insufficiency, proteinuria and heart failure caused by 'light chain deposition disease' (LCDD). A renal biopsy showed nodular glomerulosclerosis, IF examination revealed linear deposits of monoclonal lambda light chains along the glomerular and tubular basement membranes. Similar deposits could be shown in a skin biopsy. No light chains could be detected in urine and serum. The patient had a good response to treatment with melphalan and prednisone.
authors.forename: R J
authors.initials: RJ
authors.lastname: van Klaveren
authors.forename: R S
authors.initials: RS
authors.lastname: Holdrinet
authors.forename: K J
authors.initials: KJ
authors.lastname: Assmann
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000368:Aged; D005455:Fluorescent Antibody Technique; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D010265:Paraproteinemias / Q000150:complications*
chemical_list: D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains
vernacular_title: Neerslag van lichte ketens in verscheidene organen; 'light chain deposition disease'.