title: Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia.
abstract: Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when alpha 2-plasmin inhibitor (alpha 2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients when the alpha 2-PI level has decreased significantly.
authors.affiliation: Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okajima
authors.forename: S
authors.initials: S
authors.lastname: Koga
authors.forename: H
authors.initials: H
authors.lastname: Okabe
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Takatsuki
mesh_terms: D003432:Cross-Linking Reagents; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis
chemical_list: D003432:Cross-Linking Reagents; D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin