Structure and regulation of muscarinic receptors.
Our knowledge of muscarinic receptor structure, mechanism, and regulation has increased enormously over the past five years. At this time, expression of receptor subtype and coupling via signal transducing elements to specific effector systems seems to be cell or tissue specific events. Determining the specific detailed molecular mechanisms of interaction for the various permutations of receptors and effector proteins and how the effector systems initiate physiological responses are challenging areas for future research.
Schimerlik
M I
MI
Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331.
D000818:Animals; D003001:Cloning, Molecular; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008024:Ligands / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*; D012995:Solubility
D008024:Ligands; D011976:Receptors, Muscarinic; D019204:GTP-Binding Proteins