title: Food-induced alterations of intestinal permeability in children with cow's milk-sensitive enteropathy and atopic dermatitis.
abstract: Intestinal permeability was evaluated by measuring the excretion of two orally absorbed (0.1 g/kg of weight) nonmetabolizable markers, mannitol and lactulose. In 39 controls, the lactulose/mannitol urinary ratio (L/M ratio) was 2.45 +/- 1.01% during fasting and remained stable after food ingestion. In 12 children with cow's milk-sensitive enteropathy under an exclusion diet, the L/M ratio was comparable with that of controls during fasting and exhibited a threefold rise during a provocation intestinal permeability test (IPT) with milk. In 28 children with atopic dermatitis (AD), the fasting IPT L/M ratio was significantly higher than in controls (3.60 +/- 3.31%). This rise was related to an increase of lactulose urinary clearance. A provocation IPT with food induced significant L/M ratio changes only in the group in which the food was proved to be responsible for the exacerbation of skin lesions. We concluded that in cow's milk-sensitive enteropathy, an IPT allows a good evaluation of mucosal reactivity to milk, and in AD, permeability changes are present in at least some cases with cutaneous lesions clearly related to food ingestion.
authors.affiliation: Hôpital St. Vincent de Paul, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Dupont
authors.forename: E
authors.initials: E
authors.lastname: Barau
authors.forename: P
authors.initials: P
authors.lastname: Molkhou
authors.forename: F
authors.initials: F
authors.lastname: Raynaud
authors.forename: J P
authors.initials: JP
authors.lastname: Barbet
authors.forename: L
authors.initials: L
authors.lastname: Dehennin
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D005512:Food Hypersensitivity / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D008892:Milk / Q000009:adverse effects*; D010539:Permeability; D011852:Radioallergosorbent Test
chemical_list: D008353:Mannitol; D007792:Lactulose