A multivariate approach to saccharide quantitative structure-activity relationships exemplified by two series of 9-hydroxyellipticine glycosides.
Multivariate saccharide quantitative structure-activity relationships (QSARs) have been developed for two series of 9-hydroxyellipticine glycosides. In order to describe the structural variation of the glycoside moieties, thirteen chromatographic variables were used. Eleven D-glycosides and seven L-glycosides were used in separate QSARs to model 9-hydroxyellipticine glycoside antitumour activity against L 1210 leukemia. The multivariate partial least squares (PLS) method was used to establish the QSARs.
Jonsson
J
J
Department of Organic Chemistry, Umeå University, Sweden.
Eriksson
L
L
Hellberg
S
S
Sjöström
M
M
Wold
S
S
D000818:Animals; D000970:Antineoplastic Agents; D004611:Ellipticines / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D015999:Multivariate Analysis; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine