title: Aneurysm associated with chronic mucocutaneous candidiasis during long-term therapy with ketoconazole.
abstract: A little girl who was suffering from chronic mucocutaneous candidiasis also had a cellular immune deficiency and undetectable IgA levels. She was treated continuously for 6 years with ketoconazole at the same dosage of 200 mg/day. She was rapidly clear from infection and did not relapse although her immune abnormalities persisted. During this long-term therapy, voluminous fusiform intracranial aneurysm appeared, causing a paresis of the four limbs. Are they mycotic aneurysms?
authors.affiliation: Service de Dermatologie, Centre Hospitalier Universitaire, Caen, France.
authors.forename: D
authors.initials: D
authors.lastname: Leroy
authors.forename: A
authors.initials: A
authors.lastname: Dompmartin
authors.forename: J P
authors.initials: JP
authors.lastname: Houtteville
authors.forename: J
authors.initials: J
authors.lastname: Theron
mesh_terms: D000328:Adult; D000785:Aneurysm, Infected / Q000209:etiology*; D002177:Candidiasis / Q000150:complications*; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004406:Dysgammaglobulinemia / Q000150:complications; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D002532:Intracranial Aneurysm / Q000209:etiology*; D007654:Ketoconazole / Q000008:administration & dosage*; D008134:Long-Term Care
chemical_list: D007654:Ketoconazole