title: Release of high molecular weight-neutrophil chemotactic activity from human tissues, cells and secretion.
abstract: Release of high molecular weight-neutrophil chemotactic activity from human tissues, cells and secretion was studied in vivo and in vitro. Lung, nasal turbinate, nasal polyps, skin of neurofibromatosis, basophils from chronic myeloid leukemia and cultured basophilic cells from cord blood released this mediator following calcium ionophore, antigen, anti-IgE or homogenization in vitro. Its release was also demonstrated in human nasal secretions from patients with allergic rhinitis following antigen challenge. Regarding mononuclear cells no release of this mediator was observed from normal donors or asthmatic patients having no active attack upon challenge with calcium ionophore, phytohemagglutinin or antigen. Homogenized duodenum released high molecular weight-neutrophil chemotactic activity but less activity in comparison with other tissues or cells mentioned above.
authors.affiliation: Division of Allergy, National Children's Medical Research Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nagakura
authors.forename: T
authors.initials: T
authors.lastname: Onda
authors.forename: K
authors.initials: K
authors.lastname: Akimoto
authors.forename: H
authors.initials: H
authors.lastname: Nagakura
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: Y
authors.initials: Y
authors.lastname: Iikura
mesh_terms: D001249:Asthma / Q000503:physiopathology; D001491:Basophils / Q000502:physiology; D002630:Chemotactic Factors / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D004386:Duodenum / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008168:Lung / Q000503:physiopathology; D009298:Nasal Polyps / Q000503:physiopathology; D009299:Nasal Provocation Tests; D009456:Neurofibromatosis 1 / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology*; D009666:Nose / Q000502:physiology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology
chemical_list: D002630:Chemotactic Factors