[Mechanisms of impairment of DNA repair in human cells. Interferons stimulated DNA repair in xeroderma pigmentosum cells].
DNA repair synthesis and strand break DNA repair induced by 4-nitroquinoline-1-oxide and UV-irradiation in Xeroderma pigmentosum lymphocytes and fibroblasts pretreated by leucocyte interferons were studied. Stimulation of DNA repair synthesis in interferon-pretreated Xeroderma pigmentosum cells, defective in incision, was detected. No such effect was noted for strand break DNA repair. Hence, antimutagenic activity of interferons in human cells is connected with their modificating effect on DNA repair.
Sinel'shchikova
T A
TA
Chekova
V V
VV
Zasukhina
G D
GD
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics* / Q000378:metabolism
D007370:Interferon Type I; D015112:4-Nitroquinoline-1-oxide
Mekhanizmy narusheniĭ reparatsii DNK v kletkakh cheloveka. Interferon stimuliruet reparativnyĭ sintez DNK v kletkakh pigmentnoĭ kserodermy.