Massive systemic amyloidosis associated with light-chain deposition disease.
A 72-year-old woman presented with rapidly progressive renal failure and multiple myeloma. The patient died 6 months later of severe hepatic insufficiency. The light-microscopic, immunological and ultrastructural findings showed widespread kappa-light-chain deposits including the kidneys, liver, spleen, heart, lungs, tongue, ovary, pancreas and bone marrow associated with massive AL amyloid deposits in the same organs and in the thyroid gland. The concurrent presence of two different deposits is very unusual and the possible mechanisms for such an association are discussed.
Troussard
X
X
Department of Haematology, CHU Clemenceau, Caen, France.
Hurault de Ligny
B
B
Gallet
B
B
Ganeval
D
D
Mandard
J C
JC
Ryckelynck
J P
JP
Leporrier
M
M
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007668:Kidney / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure
D007147:Immunoglobulin Light Chains