title: A proliferative inflammation in the mandible caused by implantation of an infected dental root. A possible experimental model for chronic osteomyelitis.
abstract: In order to provide a better understanding of the reactions of bone affected by an infectious stimulus, infected dental roots were implanted into the mandibular bone of 5 monkeys (Macaca fascicularis). The roots were infected by micro-organisms belonging to the monkeys' oral plaque flora. Following an observation period of 6 months, the monkeys were sacrificed. The mandibles were dissected. Radiographs were taken and then the mandibles were prepared for histology. In the mandibles where the infected roots had been implanted, advanced inflammatory changes were seen. Bacteria, however, were only found within the implanted roots, not in the surrounding tissue in spite of a heavy inflammatory reaction. The interaction between infection and inflammation is discussed on the basis of these observations. The role of possible neural transmittor substances in the pathogenesis of the inflammatory disease is also discussed. The signs and symptoms of the proliferative inflammatory changes provoked in this experiment are compared to those of chronic osteomyelitis.
authors.affiliation: Department of Oral Pathology, Karolinska Institutet, School of Dentistry, Huddinge, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Wannfors
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology; D004195:Disease Models, Animal; D005491:Focal Infection, Dental / Q000382:microbiology; D008252:Macaca fascicularis; D008336:Mandibular Diseases / Q000209:etiology* / Q000473:pathology; D010000:Osteitis / Q000209:etiology* / Q000473:pathology; D010019:Osteomyelitis / Q000209:etiology* / Q000473:pathology; D014076:Tooth Diseases / Q000382:microbiology; D014092:Tooth Root / Q000382:microbiology