Vitamin D in Paget's disease of bone.
The role of vitamin D metabolism in Paget's disease of bone has not been well defined. Serum levels of the main, circulating vitamin D metabolites were measured in 23 patients with Paget's disease. Values of 25(OH)D3 and 24,25(OH)2D3 were within the normal range in most (more than 90%) of the subjects. 1,25(OH)2D3 was increased in 11 (48%) patients. Markedly elevated levels (93-298 pg/ml) were found in five patients. In a subgroup of patients with high 1,25(OH)2D3, the mean serum alkaline phosphatase activity was insignificantly higher, while serum calcium, phosphorous, and kidney function were the same as in a subgroup with normal 1,25(OH)2D3. 1,25(OH)2D3 levels were not affected by treatment with either calcitonin or etidronate disodium. Serum 1,25(OH)2D3 levels may be increased in a subset of patients with Paget's disease of bone.
Foldes
J
J
Unit of Metabolic Bone Diseases, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Shamir
S
S
Kidroni
G
G
Menczel
J
J
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000378:metabolism; D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D012968:Etidronic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*
D014807:Vitamin D; D002116:Calcitonin; D000469:Alkaline Phosphatase; D012968:Etidronic Acid; D002118:Calcium