title: Abnormalities in arachidonic acid metabolites in nephrotoxic glomerular injury.
abstract: Arachidonic acid metabolites are suspected of contributing in various ways to major pathophysiological events that occur in toxic and immune glomerular injury. This paper focuses on the role of arachidonate metabolites in the experimental models of adriamycin nephrosis and cyclosporin A nephrotoxicity in rats as examples, respectively, of a toxic nephropathy characterized by increased glomerular permeability to proteins and a toxic nephropathy with macrophage accumulation and progressively deteriorating renal function. The important pathogenic contribution of thromboxane A2 to the impairment of renal function in these experimental models is discussed.
authors.affiliation: Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Zoja
authors.forename: N
authors.initials: N
authors.lastname: Perico
authors.forename: G
authors.initials: G
authors.lastname: Remuzzi
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051381:Rats
chemical_list: D001095:Arachidonic Acids; D016718:Arachidonic Acid