[Recovery of impaired respiratory activity in cats by thyroliberin analog (PR-546) devoid of hormonal properties].
Synthetic analogue thyroliberin (PR-546) devoid of hormonal activity, recovered respiration in conditions of hyperventilation, two-sided vagotomy and hypoxia, caused by the 40-70% bleeding. PR-546 (in doses 100-500 micrograms/kg) intravenously injected was shown to abolish diagram activity decreased effect after hyperventilation. Injection of PR-546 to vagotomized cats in 1.5-2 h, increased breathing rate. The breathing activity resumed after long breaks in respiration as a result of peptide injection. The responses to analogue introductions is similar to the thyroliberin effect.
Gurskaia
I E
IE
Serbeniuk
Ts V
TsV
Sliuta
A D
AD
Romanovskiĭ
P Ia
PIa
D000818:Animals; D002415:Cats; D006985:Hyperventilation / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000031:analogs & derivatives; D014628:Vagotomy
C060662:PR 546; D013973:Thyrotropin-Releasing Hormone
Vosstanovlenie narushennoĭ dykhatel'noĭ aktivnosti koshek analogom tiroliberina (PR-546), lishennym gormonal'nykh svoĭstv.