Reduced levels of mutagen processing potential in the Schistosoma japonicum-infected mouse liver.
Epidemiological studies have shown the presence of a positive correlation between the infection of Schistosoma japonicum and colorectal and/or liver cancers in the humans. To explore the mechanism underlying this correlation, we have investigated the mutagen-activating potentials of the liver homogenate fraction (S9) from Schistosoma japonicum infected mice and those from control mice, by use of the Ames test with 2-acetylaminofluorene, aflatoxin B1 and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) as test mutagens. Liver S9 prepared from the infected group at the 15th week after the infection showed a potential significantly lower than that from the control group. The hepatic cytochrome P-450 concentration in the infected mice was persistently low, about a half of that in the uninfected mice, during the period of 6-18 weeks after the infection. Thus, in mice bearing chronic schistosomiasis, mutagen-processing potentials are decreased.
Matsuoka
H
H
Department of Parasitology, Okayama University Medical School, Japan.
Aji
T
T
Ishii
A
A
Arimoto
S
S
Wataya
Y
Y
Hayatsu
H
H
D015073:2-Acetylaminofluorene / Q000378:metabolism; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D002243:Carbolines / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism* / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism* / Q000493:pharmacokinetics; D012486:Salmonella typhimurium / Q000235:genetics; D012554:Schistosomiasis japonica / Q000378:metabolism*
D000348:Aflatoxins; D002243:Carbolines; D009153:Mutagens; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; D003577:Cytochrome P-450 Enzyme System; D015073:2-Acetylaminofluorene; D016604:Aflatoxin B1