Repetitive seizures cause an increase in paired-pulse inhibition in the dentate gyrus.
A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h after 36 seizures and a further increase after 72 seizures. These data demonstrate that the same experimental protocol which produced a decrease in paired-pulse inhibition in the CA1 region caused the opposite effect in the dentate gyrus.
Stringer
J L
JL
Department of Neurology, University of Virginia Medical Center, Charlottesville 22908.
Lothman
E W
EW
D000758:Anesthesia; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008297:Male; D009433:Neural Inhibition; D011712:Pyramidal Tracts / Q000166:cytology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*