title: [Synthesis of 11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)] dodeca-5,9-dien-8-ol].
abstract: Structural reconstruction from natural non-alkaloidal compounds might lead to new bioactivity. In this paper, the synthesis of one of such compounds--11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)]dodeca-5, 9-dien-8-ol was reported. The compound was derived from curcumol via a tropone compound as an intermediate and was found to have an activity of markedly lowering blood pressure in anesthetized rats.
authors.forename: Y T
authors.initials: YT
authors.lastname: Guo
authors.forename: X M
authors.initials: XM
authors.lastname: Du
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000138:chemical synthesis*; D051381:Rats
chemical_list: D000959:Antihypertensive Agents; D004224:Diterpenes; C062552:11-aminomethyl-2,6-dimethyl-3,9-diisopropyltricyclo(5.3.2.0)dodeca-5,9-dien-8-ol