Heterogeneity of murine gut epithelium: three subsets defined by expression of dendritic cell markers.
Recent evidence has been provided for the immunological role of MHC class II molecules constitutively expressed by small intestinal epithelial cells (EC) in antigen presentation to specific T cells. Using immunohistochemical methods and antibodies to molecules expressed by dendritic cells (DC), considered as the most potent antigen presenting cell type, we observed that mature enterocytes of gut villi share common antigens with DC. Furthermore, these markers defined the heterogeneity of intestinal epithelium characterized by the presence of three EC subsets with distinct phenotype: immature crypt EC, Peyer's patch (PP) dome EC, and mature villi EC.
Vidal
K
K
Inserm U80 CNRS URA 1177 UCBL, Pavillon P, Hopital E. Herriot, Lyon, France.
Kaiserlian
D
D
Revillard
J P
JP
D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D015415:Biomarkers; D003713:Dendritic Cells / Q000276:immunology*; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000276:immunology*; D051379:Mice; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000941:Antigens; D015415:Biomarkers