[A combination of nifedipine and diltiazem in the treatment of refractory spastic angina].
Both diltiazem (D) and nifedipine (N) have been shown to be effective in the treatment of spastic angina, but they sometimes prove inadequate, even in high doses. These two drugs have been given in combination on the grounds of a possible synergistic action, but the results obtained were limited by side-effects. We decided to administer the combined treatment in half doses to patients with spastic angina and normal coronary vessels in order to assess its effectiveness and acceptance. The trial was conducted on 13 patients: 11 men and 2 women aged from 37 to 71 years (mean 53 years) with normal or subnormal coronary arteriography. In the absence of any treatment, these patients responded to the ergonovine test by a coronary spasm which we were subsequently unable to prevent with either D or N. Each patient underwent, at the same hours, 4 ergonovine tests, the product being injected intravenously every 3 minutes in incremental doses of 1, 2, 3 and 6 micrograms/kg. These tests were performed without treatment, after 3 days of treatments with D alone (360 mg/kg), after 3 days of treatment with N alone (60 mg/kg) and after 3 days of treatment with D (180 mg/kg) plus N (30 mg/kg). Without treatment, ergonovine triggered the coronary spasm in all 13 patients at a mean threshold dose of 2.7 micrograms/kg. Under treatment with D or N given separately, no test became negative, but the threshold doses of ergonovine rose to 4.5 and 4.6 micrograms/kg respectively (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Bory
M
M
Service de cardiologie, CHU Timone, Marseille.
Joly
P
P
Bonnet
J L
JL
Coutelen
N
N
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D003329:Coronary Vasospasm / Q000209:etiology; D004110:Diltiazem / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008755:Methylergonovine; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D004110:Diltiazem; D009543:Nifedipine; D008755:Methylergonovine
Association de la nifédipine et du diltiazem dans le traitement de l'angor spastique réfractaire.