The structure and function of the int-2 oncogene.
The classification of int-2 as a growth factor is based primarily on the similarities between the predicted amino acid sequence and that of basic fibroblast growth factor (bFGF), as well as other members of this expanding family of related proteins. In this review, we summarise the background to the identification of int-2 as a proto-oncogene in virally induced mouse mammary tumours and describe key features of the structure and expression of both the mouse and human homologues. The normal sites of int-2 expression include specific embryonic cell types suggesting multiple inductive or morphogenetic roles. Recent progress in the characterisation of the int-2 product will be discussed in relation to the similarities and differences between int-2 and other FGFs.
Dickson
C
C
Department of Viral Carcinogenesis and Imperial Cancer Research Fund Laboratories, London, U.K.
Deed
R
R
Dixon
M
M
Peters
G
G
D000595:Amino Acid Sequence; D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D015183:Restriction Mapping
C496444:FGF3 protein, human; C489197:Fgf3 protein, mouse; D051518:Fibroblast Growth Factor 3; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors