Enhancement of human dental cyst PGI2 formation by platelet derived growth factor and its role in cyst growth and bone resorption.
Various prostaglandins, particularly PGE2 and PGI2, appear to play a major role in osteolytic processes. Radiochromatographic studies have demonstrated that 6-oxo-PGF1-alpha is a major product of exogenously added arachidonic acid in human dental cysts. As platelets may also act as inflammatory cells, platelet-derived growth factor might also have a PGI2-stimulating influence in such cysts. Eleven human dental cysts were examined by a radioimmunoassay and bioassay which can show PGI2 synthesis in human dental cysts without addition of PDGF. Incremental PDGF addition caused a highly significant increase in the rate of PGI2 synthesis. PGDF thus stimulates PGI2 synthesis in chronic inflammatory processes in vitro and may thereby elicit or accelerate osteolysis.
Nell
A
A
Department of Dentistry, University Clinic of Vienna, Dental School, Austria.
Mailath
G
G
Porteder
H
H
Ulrich
W
W
Sinzinger
H
H
Matejka
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000378:metabolism*; D003803:Dentigerous Cyst / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011863:Radioimmunoassay
D010982:Platelet-Derived Growth Factor; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol