The effect of intrathecal galanin on the flexor reflex in rat: increased depression after sciatic nerve section.
The effect of intrathecal galanin (GAL) on the hamstring flexor reflex to sural nerve stimulation was compared in rats with intact and unilaterally sectioned sciatic nerves. GAL had a biphasic effect on the flexor reflex in rats with intact nerves, including facilitation, facilitation followed by depression and pure depression, in a dose-dependent manner. In axotomized rats, the depressive effect of GAL was significantly increased, occurring at lower drug concentrations. Furthermore, the degree of depression was significantly stronger with a more rapid onset after nerve section. It is concluded that along with an increase in GAL-like immunoreactivity in primary afferents, the inhibitory function of this neuropeptide is enhanced following axotomy. This functional change may be due to both pre- and postsynaptic mechanisms.
Wiesenfeld-Hallin
Z
Z
Department of Clinical Neurophysiology and Physiology, Karolinska Institute, Huddinge, Sweden.
Xu
X J
XJ
Villar
M J
MJ
Hökfelt
T
T
D000818:Animals; D001369:Axons / Q000502:physiology; D004576:Electromyography; D019004:Galanin; D007278:Injections, Spinal; D009412:Nerve Fibers / Q000502:physiology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects*; D012584:Sciatic Nerve / Q000502:physiology*
D010455:Peptides; D019004:Galanin