Factor VIII inhibitor in insulin-dependent diabetes mellitus.
Acquired factor VIII inhibitor was found in a 69-year-old white male with insulin-dependent diabetes mellitus. He presented with left lower abdominal pain and hematoma after a fall. Preoperative hemostasis studies were normal except for prolonged aPTT. Prolonged aPTT was not corrected by 1:1 mixture with normal fresh plasma and incubation showed further prolongation with time. Factor VIII:c was 3.5%. The inhibitor titer was 7.5 Bethesda units. The possible mechanism causing antibody to factor VIII was postulated to be an autoimmune process and/or increased immunogenicity owing to glycosylation of factor VIII coagulant protein.
Wajima
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Hematology/Oncology Section, Olin E. Teague Veterans' Center, Temple, TX 76504.
Hall
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G
D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time
D005169:Factor VIII