The experimental inoculation with Mycobacterium leprae in autoimmune mice: results of MRL/lpr mice inoculated into the right hind foot (continued).
Using MRL/lpr, NOD and Crj:CD-1 (ICR) mice, inoculations of M. leprae were made into the right hind foot at a dose of 5.8 x 10(6) bacilli per foot in order to study the influence of the immunobiological characteristics of their mice on the growth of M. leprae. To summarize of the results, MRL/lpr mice showed the high susceptibility to M. leprae, while that of NOD mice were poor. In conclusion, the immunobiological characteristics of MRL/lpr, autoimmune mice bearing lpr gene had effect on the multiplication of M. leprae, this mouse is a suitable multibacillary model for the study of leprosy.
Yogi
Y
Y
Nakamura
K
K
Suzuki
A
A
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology*; D004195:Disease Models, Animal; D005260:Female; D005528:Foot / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009166:Mycobacterium leprae / Q000254:growth & development*; D013601:T-Lymphocytes / Q000276:immunology