The in vivo effect of colony stimulating factors (CSFs) on phagocytic functions of granulocytes.
The effect of commercially available colony stimulating factors and mouse post-endotoxin serum on bactericidal activity and phagocytosis of bacteria by blood neutrophils was tested on mice in vivo after intraperitoneal injection. It was found that tested substances are able to induce phagocytosis and bactericidal activity of blood granulocytes. The similar patterns of these actions during 48 hours were observed for mouse IL-3 and human GM-CSF and for GCT-CM and post-endotoxin serum.
Szmitkowski
M
M
Department of Biochemical Diagnostics, Institute of Laboratory Diagnostics, Medical Academy, Białystok.
Cimaszewska
M
M
Kondracka
E
E
Wysocka
J
J
D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000008:administration & dosage / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000276:immunology; D013997:Time Factors
D003115:Colony-Stimulating Factors