Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors.
Three cases of renal dysfunction at birth were observed in premature babies exposed in utero to prostaglandin synthetase inhibitors (PSI) and corticosteroids. Transient water and sodium retention with uraemia occurred in one patient, and severe acute renal failure with marked hyperkalaemia in twins. These findings may be due to impairment of prostaglandin (PG)-mediated renal adaptation to stress conditions after transplacental passage of PSI. Corticosteroids may also have affected PG synthesis inhibition.
Simeoni
U
U
Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.
Messer
J
J
Weisburd
P
P
Haddad
J
J
Willard
D
D
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001623:Betamethasone / Q000009:adverse effects; D002585:Cesarean Section; D016861:Cyclooxygenase Inhibitors; D004200:Diseases in Twins; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007660:Ketoprofen / Q000009:adverse effects; D007677:Kidney Function Tests; D008297:Male; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007660:Ketoprofen; D001623:Betamethasone; D007213:Indomethacin