Development of tumour cell resistance to tumour necrosis factor does not confer resistance to cytotoxic drugs.
Tumour necrosis factor (TNF) is a protein product of macrophages with potential anti-cancer activity. As with other anti-cancer agents, tumour cells can develop resistance to the cytotoxic effects of TNF. The aim of his study was to see whether development of resistance to TNF resulted in a concomitant resistance to other anti-cancer agents, in particular those associated with multidrug resistance. Three TNF-susceptible tumour cell lines (L929, U937 and RK13) and their TNF-resistant sublines were compared for susceptibility in vitro to several cytotoxic drugs. The TNF-resistant sublines were not significantly more resistant to these drugs. In addition, an L929 subline selected for resistance to actinomycin D retained its susceptibility to TNF. These observations show that tumour cell resistance to TNF develops independently of resistance to cytotoxic drugs.
Neale
M L
ML
Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Matthews
N
N
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D003609:Dactinomycin / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
D008937:Mitomycins; D014409:Tumor Necrosis Factor-alpha; D003609:Dactinomycin; D016685:Mitomycin; D014750:Vincristine; D003078:Colchicine; D003630:Daunorubicin