Dapsone-induced haemolytic anaemia and agranulocytosis in a patient with normal glucose-6-phosphate-dehydrogenase activity.
A case of dapsone-induced severe haemolytic anaemia and agranulocytosis is described. A possible common pathogenic mechanism for the simultaneous occurrence of these side effects of dapsone therapy in a patient with normal glucose-6-phosphate-dehydrogenase activity is proposed.
Figueiredo
M S
MS
Department of Clinical Medicine, School of Medicine, Ribeirão, Preto, Brazil.
Pinto
B O
BO
Zago
M A
MA
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D003622:Dapsone / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis*; D006801:Humans
D003622:Dapsone; D005954:Glucosephosphate Dehydrogenase