Carcinosarcoma of the urinary bladder. A light, immunohistochemical and electron microscopical case report.
A case of urinary bladder carcinosarcoma (UBCS) is reported with light, immunohistochemical and electron microscopical findings. The tumour consisted of a squamous cell carcinoma, variable spindle cell stromal elements compatible with fibrosarcoma, and rhabdomyoblasts. Intermediate filament co-expression of cytokeratin and vimentin was shown by immunohistochemistry. Electron microscopy (EM) confirmed the nature of the three components, and indicated some similarities between the three cell-types present. Comparisons with the previous UBCS in the literature are made.
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Department of Histopathology, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
Eyden
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Joglekar
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D000368:Aged; D002296:Carcinosarcoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*