title: Arthropathy associated with Brucella abortus strain 19 vaccination in cattle. I. Examination of field cases.
abstract: Thirty cows presenting with lameness and persistent serological reactions to Brucella abortus had chronic granulomatous arthropathy of the femorotibial and occasionally other joints. Attempts to culture Brucella or other pathogens gave negative results but organisms of Brucella morphology were seen in fluorescent antibody-stained cryostat sections of synovial tissue. The synovial fluids contained high titres of antibodies to B. abortus and Yersinia enterocolitica O:9 and had elevated total protein and immunoglobulin concentrations showing an oligoclonal electrophoretic profile. Immune complexes and rheumatoid factor were detected in some of the fluids.
authors.forename: M J
authors.initials: MJ
authors.lastname: Corbel
authors.forename: F A
authors.initials: FA
authors.lastname: Stuart
authors.forename: R A
authors.initials: RA
authors.lastname: Brewer
authors.forename: M
authors.initials: M
authors.lastname: Jeffrey
authors.forename: R
authors.initials: R
authors.lastname: Bradley
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D002004:Brucella Vaccine / Q000009:adverse effects*; D002003:Brucella abortus / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000276:immunology; D005260:Female; D007592:Joint Diseases / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D007794:Lameness, Animal / Q000209:etiology* / Q000276:immunology; D013582:Synovial Fluid / Q000032:analysis / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary; D015008:Yersinia enterocolitica / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D002004:Brucella Vaccine