Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation.
The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3,5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the characteristic feature of epiderstatin is that it has a piperidone ring instead of a cyclohexanone ring.
Sonoda
T
T
RIKEN, The Institute of Physical and Chemical Research, Saitama, Japan.
Osada
H
H
Uramoto
M
M
Uzawa
J
J
Isono
K
K
D000903:Antibiotics, Antineoplastic; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D010880:Piperidines; D010881:Piperidones; D011728:Pyridones; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis
D000903:Antibiotics, Antineoplastic; D010880:Piperidines; D010881:Piperidones; D011728:Pyridones; C061874:epiderstatin; D004815:Epidermal Growth Factor