The synthesis of glutathione peroxidase analogs.
While it is recognized that oxidation has a major role in the development of cataract, few compounds have been developed which effectively reduce the potential for oxidative insult. A major oxidant confronting the lens is H2O2. Few compounds capable of metabolizing H2O2 have been synthesized. This communication reports that a number of compounds with glutathione peroxidase activity have been developed. Some of these compounds are 10 fold more active than Ebselen, previously recognized as the synthetic compound with the greatest GSH peroxidase activity.
Spector
A
A
Department of Ophthalmology, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Wilson
S R
SR
Zucker
P A
PA
Huang
R R
RR
Raghavan
P R
PR
D001393:Azoles / Q000737:chemistry / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000737:chemistry* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D054833:Isoindoles; D015394:Molecular Structure; D016566:Organoselenium Compounds; D012643:Selenium / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D012643:Selenium