Rhinomanometric evaluation of two nasal steroid sprays in rhinitis.
A prospective, randomized study comparing the effectiveness of two nasal steroid sprays, flunisolide and beclomethasone dipropionate, in the treatment of nasal obstruction associated with allergic or vasomotor rhinitis has been conducted at New York University Medical Center-Bellevue Hospital. All patients underwent routine history and physical examinations and a modified radioallergosorbent test. Paranasal sinus films were used to exclude patients with sinusitis. The Rhinotest microprocessor rhinomanometer was used to quantify pretreatment and posttreatment total nasal air flow and resistance during a period of 2 months. These findings were assessed in conjunction with the patients' subjective complaints. Results demonstrated that anterior rhinomanometric assessment of the nasal airway during inhalant therapy correlated well with the patients' own subjective impressions of nasal air flow. Both steroid inhalants were effective; however, flunisolide provided for earlier and more substantial symptomatic relief. Beclomethasone dipropionate had milder side effects.
Kohan
D
D
Department of Otolaryngology, New York University School of Medicine, NY 10016.
Jacobs
J B
JB
Nass
R L
RL
Gonzalez
S
S
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004809:Ephedrine / Q000627:therapeutic use; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation; D008838:Microcomputers; D008875:Middle Aged; D011446:Prospective Studies; D012123:Pulmonary Ventilation; D011897:Random Allocation; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D012223:Rhinitis, Vasomotor / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; C007734:flunisolide; D004809:Ephedrine; D001507:Beclomethasone