title: Activity of pp60c-src protein kinase in human breast cancer.
abstract: Because there is elevation of pp60c-src activity in breast carcinoma tissue, we analyzed primary breast cancer tissue samples from 30 women to determine whether pp60c-src activity correlated with specific clinical parameters. We found that tumors with a progesterone receptor had higher pp60c-src activity than tumors without such a receptor. But there was no association of pp60c-src activity with the presence of an estrogen receptor or of nodes, or with menopausal status or age. The function of pp60c-src in normal cells and in breast cancer is unknown, as is the significance of our finding of an association of elevated pp60c-src activity and the presence of progesterone receptors.
authors.forename: S
authors.initials: S
authors.lastname: Lehrer
authors.forename: J
authors.initials: J
authors.lastname: O'Shaughnessy
authors.forename: H K
authors.initials: HK
authors.lastname: Song
authors.forename: E
authors.initials: E
authors.lastname: Levine
authors.forename: P
authors.initials: P
authors.lastname: Savoretti
authors.forename: J
authors.initials: J
authors.lastname: Dalton
authors.forename: R
authors.initials: R
authors.lastname: Lipsztein
authors.forename: S
authors.initials: S
authors.lastname: Kalnicki
authors.forename: W D
authors.initials: WD
authors.lastname: Bloomer
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D015688:Oncogene Protein pp60(v-src); D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012191:Retroviridae Proteins / Q000378:metabolism*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012191:Retroviridae Proteins; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)