A new hierarchy of TCR specificity: autoimmune diseases are defined by particular V alpha V beta combinations and not by antigen specificity.
Heber-Katz
E
E
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
D000818:Animals; D000940:Antigenic Variation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell