title: [Exploration of left ventricular relaxation using gamma-angiography in 70 hypertensive subjects. Practical consequences and implications].
abstract: This study was performed to evaluate the incidence ant the practical consequences of left ventricular diastolic dysfunction in hypertensive. In 70 mild to moderate hypertensive subjects group [systolic 161 +/- 16 and diastolic blood pressure 104 +/- 9 mmHg 18 women, 52 men, 51 +/- 7 years old] and in a 15 normal subjects control group, the peak filling rate (PFR) and the time to peak filling rate (TPFR) were measured with the time/activity curve of the rest equilibrium blood pool scintigraphy. The ejection fraction and the stress test were normal in all patients [EF 0.66 +/- 0.05, ranging from 0.59 to 0.88]. The PFR was not significantly different in the hypertensive group but 59/70 patients [84 p. 100] showed an individual value lower than the theoretical age and heart rate expected value. The TPFR was not significantly different (183 +/- 33 ms-vs 180, p = ns). In a Holter-defined sub-group of patients (n = 22) exhibiting a high prevalence of supra-ventricular premature beats or a paroxysmal atrial fibrillation, the PFR was significantly slower than in the total hypertensive group [1.92 +/- 0.33 EDV/s-1, p = 0.02]. Early indices of diastolic function give some instantaneous information on left ventricular filling. Determining the exact significance of individual values of PFR and TPFR requires a better knowledge of physiologic and pathologic determinants of LV filling.
authors.affiliation: Service de cardiologie hôpital militaire du Valde-Grâce, Paris.
authors.forename: J P
authors.initials: JP
authors.lastname: Ollivier
authors.forename: J F
authors.initials: JF
authors.lastname: Gaillard
authors.forename: J
authors.initials: J
authors.lastname: Delonca
authors.forename: E
authors.initials: E
authors.lastname: Bussy
authors.forename: J M
authors.initials: JM
authors.lastname: Quatre
authors.forename: J L
authors.initials: JL
authors.lastname: Bussière
mesh_terms: D000328:Adult; D000368:Aged; D002302:Cardiac Output; D003971:Diastole; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011877:Radionuclide Imaging
vernacular_title: Exploration de la relaxation ventriculaire gauche par gamma-angiographie chez soixante-dix hypertendus. Implications et conséquences pratiques.