Detection of five circulating antigens in patients with head and neck squamous cell carcinoma.
Five tumor markers (CEA, Ferritin, CA-50, TPA and SCC) were assayed in 54 patients with ear, nose and throat (ENT) cancers in early and advanced stages. The specificity of these markers always exceeded 95%. Their sensitivity ranged from 13 to 43%, and reached 72% as a combination of all five markers. No distinction was found between early and advanced stage of illness. These markers seem to have no distinct function in ENT oncological diagnosis and follow-up because objective data is easily available even in early tumors.
Screm
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MC
Institute of Nuclear Medicine, Regional Hospital of Udine, Italy.
Grandis
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S
Cartei
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G
Cattaruzzi
E
E
D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D006258:Head and Neck Neoplasms / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D015843:Serpins; D010959:Tissue Plasminogen Activator / Q000097:blood
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; C051072:squamous cell carcinoma-related antigen; D005293:Ferritins; D010959:Tissue Plasminogen Activator