Decreased peroxidative potential in rat brain microsomal fractions during ageing.
Rough and smooth microsomes of brain in senescent rats showed less sensitivity to ascorbate-, NADPH- and cumene hydroperoxide-induced peroxidative damage compared with those of young adults. The observed decrease in peroxidative potential in senescent rats seemed to be due to decrease in the substrate for peroxidation in the form of phospholipids and increase in the level of antioxidants such as reduced glutathione and superoxide dismutase.
Devasagayam
T P
TP
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000648:ultrastructure*; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism
D001555:Benzene Derivatives; D010743:Phospholipids; D008315:Malondialdehyde; D009249:NADP; D013482:Superoxide Dismutase; D009251:NADPH-Ferrihemoprotein Reductase; D005978:Glutathione; C007164:cumene hydroperoxide; D001205:Ascorbic Acid