[Protein kinase C and its role in normal and transformed cells].
Data are reviewed on protein kinase C (PK-C) and its function in phosphorylation and regulation of different cellular proteins--enzymes, receptors, contractile and cytoskeletal proteins, as well as expression of cellular oncogenes. Besides, interactions between PK-C and cAMP-dependent PK are discussed. The evidence provided suggests that PK-C-phosphorylation may be one of the mechanisms of transformation of extracellular transmembrane signals (hormones, neuromediators, growth factors) into responsive biochemical cell reactions.
Ganelina
L Sh
LSh
Nekrasova
T P
TP
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism*; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D019204:GTP-Binding Proteins / Q000378:metabolism; D009857:Oncogenes; D010704:Phorbols / Q000494:pharmacology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D010704:Phorbols; D011506:Proteins; D011494:Protein Kinases; D011493:Protein Kinase C; D019204:GTP-Binding Proteins
Proteinkinaza C i ee rol' v normal'nykh i transformirovannykh kletkakh.