[The effect of kringles K1-3, K4 and K5 on lysis of fibrin clots caused by the activation of Glu- and Lys-plasminogen by a tissue activator].
Kringles K1-3, K4 and K5 are studied for their effect on tissue plasminogen activator-induced fibrin clot lysis in the presence of Glu- and Lys-plasminogen. It is established that kringles K4 and K5 inhibit fibrinolysis of Glu-plasminogen, and K1-3--that of Lys-plasminogen. The role of plasminogen molecule kringles in the plasminogen interaction with fibrin polymer is discussed.
Taran
L D
LD
Makogonenko
E M
EM
D001780:Blood Coagulation Tests; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D011487:Protein Conformation; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D010446:Peptide Fragments; C018998:lysyl-plasminogen; D005337:Fibrin; D010958:Plasminogen; D010959:Tissue Plasminogen Activator
Vliianie kringlov K1-3, K4 and K5 na lizis fibrinovogo sgustka, vyzvannyĭ aktivatsieĭ Glu- i Lys-plazminogena tkanevym aktivatorom.