Effect of duodenal trypsin on pancreatic secretion in men.
The effect of tryptic activity in duodenum on L-phenylalanine (100 mmol.1-1 intraduodenally) stimulated pancreatic secretion in 18 healthy volunteers has been evaluated. Intraduodenal infusion of trypsin (150 mg) during 1 h caused the reduction of alpha-amylase and lipase output by ca 30%. The infusion of aprotinin at the dose of 0.5.10(6) KIU during 30 min caused return of the alpha-amylase and lipase output to the pretryptic values. The infusion of trypsin in higher dose (300 mg) caused more pronounced decrease of amylase and lipase output (ca 45%). Our data indicate that active trypsin in duodenum is responsible for the inhibition of L-phenylalanine stimulated pancreatic enzyme secretion in man. These results corroborate the existence of feedback regulation of stimulated pancreatic secretion by intraduodenal trypsin in man.
Czajkowski
A
A
Gastroenterology Department, School of Medicine, Białystok.
Długosz
J
J
D000293:Adolescent; D000328:Adult; D007611:Aprotinin / Q000494:pharmacology; D002918:Chymotrypsin / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000378:metabolism*; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D010649:Phenylalanine / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012016:Reference Values; D014357:Trypsin / Q000378:metabolism* / Q000494:pharmacology; D000516:alpha-Amylases / Q000378:metabolism
D011506:Proteins; D010649:Phenylalanine; D007611:Aprotinin; D008049:Lipase; D000516:alpha-Amylases; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D014357:Trypsin