title: [Lack of tolerance development with low dose nitrate administration in acute myocardial infarct].
abstract: Reports on the development of tolerance have modified the use of nitrates in the treatment of coronary heart disease. Dosage limitations and nitrate-free intervals are frequently recommended to solve this problem (4, 5). In the clinical setting of acute myocardial infarction continuous application of glyceryl trinitrate (GTN) is still a widely used therapy (1). In this study we investigated whether a low-dose intravenous GTN administration leads to a rapid development of tolerance. During the observation period of 60 h, no attenuation of drug effects on the pulmonary pressures could be detected. Subsequent oral medication also showed an undiminished nitrate response.
authors.affiliation: I. Medizinische Klinik der Christian-Albrechts-Universität zu Kiel.
authors.forename: A
authors.initials: A
authors.lastname: Meissner
authors.forename: W
authors.initials: W
authors.lastname: Petermann
authors.forename: Z
authors.initials: Z
authors.lastname: Fanous
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: H M
authors.initials: HM
authors.lastname: Schulte
mesh_terms: D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects
chemical_list: D003402:Creatine Kinase; D005996:Nitroglycerin
vernacular_title: Fehlende Toleranzentwicklung mit niedrigdosierter Nitratapplikation beim akuten Myokardinfarkt.