title: Radiotherapy of choroidal metastases.
abstract: With binocular indirect ophthalmoscopy, fluorescin angiography and ultrasonography 68 choroidal metastases in 52 eyes of 39 patients were diagnosed. The primary tumors were mainly breast cancer (81%) and lung cancer (10%). After radiation treatment the visual acuity improved in 17 eyes (38%), stabilized in 15 eyes (33%), whereas in 13 eyes (29%) deterioration could not be prevented (seven eyes unknown). Regression of the lesions or its accompanying secondary retinal detachment was seen in 78% of the eyes treated. Acute transient side effects of radiation therapy were kerato-conjunctivitis (nine patients) and acute glaucoma in one patient. No cataractous changes of the lens were observed in the post radiation period (one to 42 months). Irradiation of choroidal metastases can contribute to improvement of the quality of life with a treatment scheme of 30 Gy in ten daily fractions.
authors.affiliation: Department of Radiotherapy, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Hoogenhout
authors.forename: H M
authors.initials: HM
authors.lastname: Brink
authors.forename: A M
authors.initials: AM
authors.lastname: Verbeek
authors.forename: J J
authors.initials: JJ
authors.lastname: van Gasteren
authors.forename: L V
authors.initials: LV
authors.lastname: Beex
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011882:Radiotherapy, High-Energy; D014463:Ultrasonography