title: Strategies for measuring the rate of age-related cataract formation in vivo.
abstract: The Lens Opacities Classification System (LOCS II) has been tested as a method for detecting and grading longitudinal changes in cataract severity. The LOCS I and II systems have already been tested and validated for cross-sectional classification of human cataracts in vivo. 130 eyes (of 68 patients) were photographed at baseline and follow-up visits with Neitz CTR and Zeiss slit photography. The mean length of follow-up was 14.7 +/- 4.4 months. The severity of nuclear opalescence (NO), cortical (C) and posterior subcapular cataract (P) was graded in a masked fashion using the LOCS II standards. Side-by-side comparisons of baseline and follow-up photos were also done in a masked fashion to detect more subtle changes than might be evident in the LOCS II gradings. The annual percent progression in cataracts graded by LOCS II standards are: (NO): 12.4%, (C): 17.9%, and (P): 6.5%. The LOCS II standards are offered as a promising subjective method for longitudinal grading of human cataractous change in vivo.
authors.affiliation: Center for Clinical Cataract Research, Brigham and Women's Hospital.
authors.forename: L T
authors.initials: LT
authors.lastname: Chylack
authors.forename: M C
authors.initials: MC
authors.lastname: Leske
authors.forename: P
authors.initials: P
authors.lastname: Khu
authors.forename: D
authors.initials: D
authors.lastname: McCarthy
authors.forename: S Y
authors.initials: SY
authors.lastname: Wu
mesh_terms: D000368:Aged; D000375:Aging; D002386:Cataract / Q000145:classification* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007904:Lens Cortex, Crystalline / Q000473:pathology; D007907:Lens Nucleus, Crystalline / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010781:Photography; D015203:Reproducibility of Results