Oltipraz treatment in experimental schistosomiasis mansoni: III. Effect of high dose oral therapy on hepatic shift of worms and tissue bound ova pattern in infected mice.
Oltipraz was given in a single oral dose of 500 mg per kg body weight to mice experimentally infected with the Egyptian strain of S. mansoni. The drug caused marked hepatic shift of the worms in comparison to the infected untreated controls. Hepatic shift of worms was apparent till the 30th. day from oltipraz administration, while pronounced back shift to mesenteric veins by the surviving parasites occurred 60 days post-treatment. The drug also caused death of all bilharzial eggs located inside tissues of the small intestines of infected mice and complete eradication of faecal eggs after the 5th., 7th., 20th., 30th. and 60th. days from therapy. These findings are in need of histopathological investigations.
Aboul-Atta
A M
AM
Hassan
Z A
ZA
el-Ahl
S S
SS
D000818:Animals; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D011719:Pyrazines / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000502:physiology; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D012556:Schistosomicides / Q000627:therapeutic use*; D013871:Thiones; D013876:Thiophenes
D011719:Pyrazines; D012556:Schistosomicides; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz