[Stages of B-lymphocyte differentiation in acute lymphoblastic leukemia].
Blasts phenotype was determined in 61 children with the acute lymphoblastic leukemia. Non-T-cell acute lymphoblastic leukemia was diagnosed in 51 children. Stages of blasts differentiation were determined with the aid of monoclonal antibodies set using alkaline phosphatase-anti-alkaline phosphatase technique. Blasts in 50 patients belonged to B subpopulation confirmed by the presence of panB CD19 and CD22 antigens. Common antigen was seen in 76.5% of the examined patients with non-T-cell acute lymphoblastic leukemia. Cases of non-T-cell acute lymphoblastic leukemia were divided into 8 subgroups depending on the antigens of B-cells differentiation. An identification of pre-B subgroups of the acute lymphoblastic leukemia indicates heterogenicity of the acute lymphoblastic leukemias in childhood and enables their classification into groups corresponding to the early stages of lymphoblasts maturation.
Koehler
M
M
Bubała
H
H
Sońta-Jakimczyk
D
D
Guzikowska
E
E
Janik-Moszant
A
A
Wieczorek
M
M
Hołowiecki
J
J
D000911:Antibodies, Monoclonal / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D014408:Biomarkers, Tumor
Stadia zróznicowania limfocytów "B" w ostrej białaczce limfoblastycznej.