title: Primary treatment of regional and disseminated pancreatic cancer with hexamethylmelamine, mitomycin C and 5-fluorouracil infusion.
abstract: Hexamethylmelamine, mitomycin C and 5-fluorouracil infusion (HexMF) achieved a median survival of 9 months for the 45 patients with either metastatic stage III or unresectable stage II carcinoma of the pancreas. Fifteen percent survived 2 years. Of 32 patients with measurable tumors, 7 had partial and 3 had minor responses (31%); an additional 44% has stable disease for 3 months or more. Response was associated with a 17-month median survival. These findings are indications for further evaluation of both dosage-intensive 5-fluorouracil infusions alone and HexMF as an alternative to streptozotocin- or adriamycin-containing regimens. Patients with nonmeasurable disease are candidates for survival-oriented phase III studies.
authors.affiliation: Mount Sinai School of Medicine, New York, N.Y.
authors.forename: H W
authors.initials: HW
authors.lastname: Bruckner
authors.forename: J
authors.initials: J
authors.lastname: Kalman
authors.forename: M
authors.initials: M
authors.lastname: Spigelman
authors.forename: M I
authors.initials: MI
authors.lastname: Gorbaty
authors.forename: N
authors.initials: N
authors.lastname: Butwell
authors.forename: J
authors.initials: J
authors.lastname: Storch
authors.forename: A
authors.initials: A
authors.lastname: McKenna
mesh_terms: D006585:Altretamine / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D006585:Altretamine; D005472:Fluorouracil