title: Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome.
abstract: In order to identify all X-linked zygotic lethal loci that exhibit a specific maternal effect on embryonic development, germline clonal analyses of X-linked zygotic lethal mutations have been performed. Two strategies were employed. In Screen A germline clonal analysis of 441 mutations at 211 previously mapped X-linked loci within defined regions was performed. In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed. These approaches provide an 86% level of saturation for X-linked late zygotic lethals (larval and pupal) with specific maternal effect embryonic lethal phenotypes. The maternal effect phenotypes of these mutations are described.
authors.affiliation: Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: N
authors.initials: N
authors.lastname: Perrimon
authors.forename: L
authors.initials: L
authors.lastname: Engstrom
authors.forename: A P
authors.initials: AP
authors.lastname: Mahowald
mesh_terms: D000818:Animals; D002999:Clone Cells; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D008040:Genetic Linkage; D006720:Homozygote; D009154:Mutation; D009866:Oogenesis; D010641:Phenotype; D014960:X Chromosome; D015053:Zygote