Effects of lipid peroxidation on GABA uptake and release in iron-induced seizures.
Intraventricular injection of iron causes seizures and lipid peroxidation in brain tissue. To determine the effects of iron-induced lipid peroxidation on GABA uptake and release, synaptosomal fraction was prepared from 30-day-old iron-treated and control Wistar rats. Our data demonstrated that GABA release was more severely damaged than GABA uptake by lipid peroxidation. This imbalance between release and uptake may reduce GABA inhibition, which could contribute to the neurochemical pathogenesis of iron-induced seizures.
Zhang
Z H
ZH
Zuo
Q H
QH
Wu
X R
XR
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D007501:Iron / Q000009:adverse effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D007501:Iron