title: Algorithm for computing oxygen dissociation curve with pH, PCO2, and CO in sheep blood.
abstract: By extending the study of Samaja and Gattinoni, an algorithm is described for computing the oxygen dissociation curve with variations in pH, PCO2, and CO in homozygous HbB sheep blood. The difference in the values of O2 pressure at 50% saturation in presence of CO computed from the present algorithm and Hill's equation does not exceed 0.5%. It is shown that O2 affinity increases as the concentration of CO or pH increases or PCO2 decreases. The algorithm is convenient for representing the oxygen dissociation curve with variation in pH, PCO2 and the concentration of CO in modelling oxygen transport in sheep blood even under hypoxic conditions.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205.
authors.forename: M
authors.initials: M
authors.lastname: Sharan
authors.forename: A S
authors.initials: AS
authors.lastname: Popel
mesh_terms: D000465:Algorithms; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002248:Carbon Monoxide / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008432:Mathematical Computing; D008954:Models, Biological; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D012756:Sheep / Q000097:blood*
chemical_list: D002245:Carbon Dioxide; D002248:Carbon Monoxide; D010100:Oxygen