Absorption and excretion in the experimental animal of a 14C-ethylmaleimide labelled peptide fraction of bovine factor VIII with antihaemorrhagic activity.
In this study the absorption and excretion of a peptide fraction from bovine Factor VIII (Vueffe) with antihaemorrhagic activity were investigated in rats and rabbits. The results obtained suggest that the peptide fraction may be absorbed from the gastrointestinal tract through an active transport or a process of nonselective pinocytosis. The radioactivity elimination was rapid and almost complete within 24 h. In addition no difference was observed between single or repeated dosing in the pharmacokinetic parameters. The evidence following routes of administration shows the good bioavailability of this peptide fraction of low molecular weight and confirms the efficacy after oral administration at very low doses.
Conte
A
A
Institute of Biological Chemistry, University of Pisa, Italy.
Palmieri
L
L
Ronca
G
G
D000284:Administration, Oral; D000818:Animals; D002417:Cattle; D005033:Ethylmaleimide / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005169:Factor VIII / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D010455:Peptides; D005169:Factor VIII; D005033:Ethylmaleimide