[Effect of estradiol on lipolytic processes in the blood and adipose tissue of female rats].
The effect of estradiol on lipolysis in blood and in adipose tissue of female rat has been investigated. The hormone was administered to the studied animals subcutaneously during 20 days. The lipid mobilizing activity was determined in blood serum according to the four different experimental protocols: test serum--test tissue, test serum--control tissue, control serum--test tissue, and control serum--control tissue. Blood serum concentrations of triglycerides, free fatty acids and glucose, as well as lipolytic activity against exogenous substrate, were determined in addition. Estradiol administration was found to enhance the activity of factors potentiating lipolysis both in the blood and in adipose tissue of female rats, inasmuch as an increase in free fatty acids and triglyceride concentration, and a decrease in glucose concentration were observed during the period of administration of the hormone.
Uryszek
W
W
Paluszak
J
J
Uryszek
E
E
Soszyńska
Z
Z
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D007279:Injections, Subcutaneous; D008053:Lipid Mobilization / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D045166:Estradiol Congeners; D008055:Lipids; D004958:Estradiol
Wpływ estradiolu na procesy lipolityczne we krwi i tkance tłuszczowej samicy szczura.