title: Effect of thyrotropin-releasing hormone (TRH) on the chemiluminescence (CL) activity of human mononuclear cells.
abstract: The effect of the tripeptide TRH on the chemiluminescence activity of human monocytes was tested. TRH significantly (p less than 0.002) inhibited monocytes activity at pharmacological concentrations of 2 x 10(-4) M/L. The effect was not mediated via Ia or C3a-receptors as was proven by the preincubation of monocytes with the monoclonal antibodies OKIa1 and anti-C3a. Heat inactivation abolished the effect of TRH. This study has demonstrated for the first time, that pharmacological doses of TRH which had already been tentatively employed as a therapeutic agent in men can modulate immunocompetent cells.
authors.affiliation: Department of Internal Medicine II, Technical University of Munich, West Germany.
authors.forename: C
authors.initials: C
authors.lastname: Lersch
authors.forename: C
authors.initials: C
authors.lastname: Hammer
authors.forename: F
authors.initials: F
authors.lastname: Krombach
authors.forename: H
authors.initials: H
authors.lastname: Dancygier
mesh_terms: D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
chemical_list: D013973:Thyrotropin-Releasing Hormone