title: Triazolam attenuates amphetamine but not morphine conditioned place preferences.
abstract: In a series of four experiments the benzodiazepine triazolam was tested for reinforcing effects and for effects on reinforcement induced by amphetamine and morphine. Reinforcement was assessed in a conditioned place preference paradigm. Triazolam did not produce reinforcing or aversive effects when administered in doses ranging from 0.0625 to 0.5 mg/kg. Triazolam did attenuate reinforcing effects produced by 0.75 and 1.25 mg/kg amphetamine. No effect of triazolam was observed on morphine-induced reinforcement. These results indicate that the administration of triazolam can affect the brain mechanisms that mediate the reinforcing effects of amphetamine but not morphine.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, GA.
authors.forename: H O
authors.initials: HO
authors.lastname: Pettit
authors.forename: W R
authors.initials: WR
authors.lastname: Batsell
authors.forename: K
authors.initials: K
authors.lastname: Mueller
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D014229:Triazolam / Q000494:pharmacology*
chemical_list: D014229:Triazolam; D009020:Morphine; D000661:Amphetamine