Dissociation between c-fos gene expression and DNA synthesis in rat parotid glands.
Two experimental approaches were used to examine the relationship between c-fos gene expression and tissue proliferative responses. Beta-Adrenergic and muscarinic receptor stimulation yielded equivalent levels of c-fos expression, although only beta-adrenergic receptor agonists are reported as capable of eliciting DNA synthesis in parotid cells. Similarly, beta-adrenergic stimuli evoked comparable levels of c-fos expression in parotid cells from 2- and 12-month-old rats, whereas DNA synthesis has been shown to be much greater in younger animals. The results indicate that enhanced c-fos expression by itself is incapable of eliciting proliferative responses in rat parotid glands.
Mirels
L
L
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda, MD 20892.
Baum
B J
BJ
Kousvelari
E
E
D000375:Aging; D000818:Animals; D015152:Blotting, Northern; D002217:Carbachol / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004837:Epinephrine / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D002217:Carbachol; D004247:DNA; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine