title: The relationship of insulin antibodies, platelet-fixing immune complexes and platelet-associated IgG to in vitro platelet aggregation and thromboxane B2 synthesis in childhood type 1 (insulin-dependent) diabetes mellitus.
abstract: The relationship of insulin antibodies, platelet-fixing soluble immune complexes and platelet associated IgG to in vitro platelet aggregation and thromboxane B2 synthesis was studied in a group of children with type 1 (insulin-dependent) diabetes mellitus. Insulin antibodies, through the formation of insulin anti-insulin platelet-fixing immune complexes, seem to increase the levels of platelet associated IgG and both insulin immunity and increased platelet associated IgG are associated with the highest degree of platelet aggregation and thromboxane synthesis. These data suggest a possible role of immune factors in the platelet disfunction of diabetic subjects. Both platelet abnormalities and immune factors have been thought to play a role in the pathogenesis of the late diabetic complications. In this paper data concerning a possible interaction between these two factors are presented.
authors.affiliation: Istituto di Clinica Medica I, University of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Triolo
authors.forename: G
authors.initials: G
authors.lastname: Davì
authors.forename: E
authors.initials: E
authors.lastname: Giardina
authors.forename: F
authors.initials: F
authors.lastname: Cardella
authors.forename: F
authors.initials: F
authors.lastname: Meli
authors.forename: A
authors.initials: A
authors.lastname: Strano
authors.forename: G D
authors.initials: GD
authors.lastname: Bompiani
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D002648:Child; D003094:Collagen / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis*; D066298:In Vitro Techniques; D007330:Insulin Antibodies / Q000032:analysis*; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation; D012016:Reference Values; D013929:Thromboxane B2 / Q000096:biosynthesis / Q000097:blood*
chemical_list: D001095:Arachidonic Acids; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007330:Insulin Antibodies; D010972:Platelet Activating Factor; D016718:Arachidonic Acid; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine