title: Serotonin and treatment in obsessive-compulsive disorder.
abstract: Recognized since the Middle Ages, and clearly described for more than 100 years, obsessive-compulsive disorder (OCD) continues to intrigue and challenge mental health professionals. Recent evidence has implicated dysfunctional serotonergic neurotransmission in OCD. This review summarizes the evidence favoring a serotonergic hypothesis for OCD followed by a more detailed discussion of the implications the hypothesis holds for treatment.
authors.affiliation: Department of Psychiatry, University of Wisconsin Hospital, Madison 53792.
authors.forename: J S
authors.initials: JS
authors.lastname: March
authors.forename: L D
authors.initials: LD
authors.lastname: Gutzman
authors.forename: J W
authors.initials: JW
authors.lastname: Jefferson
authors.forename: J H
authors.initials: JH
authors.lastname: Greist
mesh_terms: D001521:Behavior Therapy; D002997:Clomipramine / Q000627:therapeutic use; D016666:Fluvoxamine; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism / Q000628:therapy*; D010091:Oximes / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000627:therapeutic use*
chemical_list: D010091:Oximes; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D002997:Clomipramine; D016666:Fluvoxamine