title: A multivariate approach to saccharide quantitative structure-activity relationships exemplified by two series of 9-hydroxyellipticine glycosides.
abstract: Multivariate saccharide quantitative structure-activity relationships (QSARs) have been developed for two series of 9-hydroxyellipticine glycosides. In order to describe the structural variation of the glycoside moieties, thirteen chromatographic variables were used. Eleven D-glycosides and seven L-glycosides were used in separate QSARs to model 9-hydroxyellipticine glycoside antitumour activity against L 1210 leukemia. The multivariate partial least squares (PLS) method was used to establish the QSARs.
authors.affiliation: Department of Organic Chemistry, Umeå University, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Jonsson
authors.forename: L
authors.initials: L
authors.lastname: Eriksson
authors.forename: S
authors.initials: S
authors.lastname: Hellberg
authors.forename: M
authors.initials: M
authors.lastname: Sjöström
authors.forename: S
authors.initials: S
authors.lastname: Wold
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D004611:Ellipticines / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D015999:Multivariate Analysis; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine