[Axon regeneration in the Trembler mouse, with mutation affecting Schwann cells].
Elongation, branching and regeneration rate of axons are increased (two folds) in Trembler tibial nerve after local freezing and control grafting (NNN; TrTrTr). After chimera transplantation (NTrN), normal regenerating axons are increased by 50% when they grow within a mutant (Tr) as compared to a normal (N) graft. Our results emphasize the influence of the density of Schwann cells and multi-layered basal laminas which characterize Trembler peripheral nerves.
Ferzaz
B
B
Université de Bordeaux-I, C.N.R.S. U.R.A. n 1126, Laboratoire de Neurologie du Développement, Talence.
Koenig
H
H
Ressouches
A
A
D000818:Animals; D001369:Axons / Q000502:physiology*; D005615:Freezing; D051379:Mice; D008818:Mice, Neurologic Mutants; D009154:Mutation; D009416:Nerve Regeneration; D012583:Schwann Cells; D013979:Tibial Nerve / Q000502:physiology / Q000637:transplantation
Régénération des axones chez la souris Trembler, porteuse d'une mutation affectant les cellules de Schwann.