title: [The effect of synthetic proteinase inhibitors of the level of human recombinant proinsulin production, secreted by a genetically engineered strain of Bacillus subtilis].
abstract: Influence of O,O,-diethyl-1-(N-alpha-hydrohexafluoroisobutyryl)amino-1- methylpropylphosphonate and O,O-diisobutyl-1-[2-(ethoxycarbonyl)aminoperfluoroprop-2-yl] -1- methylpropylphosphonate on the level of production of human proinsulin secreted by a genetically engineered culture Bacillus subtilis AJ 73 (pBINS1.0.) has been studied. The above phosphonates, being non-toxic for microorganisms, reduced degradation of proinsulin by serine proteinases.
authors.forename: E V
authors.initials: EV
authors.lastname: Parfenova
authors.forename: D G
authors.initials: DG
authors.lastname: Popov
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: V E
authors.initials: VE
authors.lastname: Sterkin
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Strongin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Aksinenko
authors.forename: O V
authors.initials: OV
authors.lastname: Korenchenko
authors.forename: V I
authors.initials: VI
authors.lastname: Fetisov
authors.forename: I V
authors.initials: IV
authors.lastname: Martynov
authors.forename: V B
authors.initials: VB
authors.lastname: Sokolov
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000378:metabolism*; D005818:Genetic Engineering; D006801:Humans; D007329:Insulin Antagonists; D011384:Proinsulin / Q000096:biosynthesis*; D011480:Protease Inhibitors / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000096:biosynthesis; D013552:Swine
chemical_list: D007329:Insulin Antagonists; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D011384:Proinsulin
vernacular_title: Vliianie sinteticheskikh ingibitorov proteinaz na uroven' produktsii rekombinantnogo proinsulina cheloveka, sekretiruemogo genno- inzhenernym shtammom Bacillus subtilis.