title: Changes in the binding characteristics of oestrogen and progesterone in uterine and intrauterine tissue with the progression of human pregnancy.
abstract: The binding characteristics of oestrogen and progesterone in intrauterine tissue were studied in the non-pregnant state and throughout pregnancy using sucrose density gradient centrifugation and titration analyses. High affinity receptors for these steroids which were present in high concentrations in tissue from non-pregnant patients and patients in early pregnancy, decreased with the advance of pregnancy to undetectable levels at term. Non-saturable binding to progesterone detected in term tissue was identified as albumin and cortisol binding globulin.
authors.affiliation: Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa.
authors.forename: T
authors.initials: T
authors.lastname: Padayachi
authors.forename: R J
authors.initials: RJ
authors.lastname: Pegoraro
authors.forename: G
authors.initials: G
authors.lastname: Holloway
authors.forename: S M
authors.initials: SM
authors.lastname: Joubert
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
mesh_terms: D002499:Centrifugation, Density Gradient; D004591:Electrophoresis, Polyacrylamide Gel; D005321:Extraembryonic Membranes / Q000378:metabolism; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
chemical_list: D011959:Receptors, Estradiol; D011980:Receptors, Progesterone