title: Polyamine interaction with Z-DNA.
abstract: In order to elucidate the detailed Z-DNA interaction with polyamines and also to clarify the mutual molecular recognition between the left-handed helix and the biologically important polyamine molecule, several polyamine-Z-DNA hexamer complexes were crystallized and their crystal structures were determined by X-ray diffraction. The general interaction modes found in these crystal structures were discussed in comparison with those in the complexes between polyamine and the right-handed DNA or RNA.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Hakoshima
authors.forename: K
authors.initials: K
authors.lastname: Inubushi
authors.forename: S
authors.initials: S
authors.lastname: Kunisawa
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: G A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
authors.forename: A H
authors.initials: AH
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Rich
mesh_terms: D003460:Crystallization; D004247:DNA / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D011073:Polyamines / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D011073:Polyamines; D004247:DNA