title: Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations.
abstract: The results of this study show that acquired protective immunity to Listeria monocytogenes, measured as the capacity of splenic T cells to passively transfer acquired resistance to normal syngeneic recipients, was mediated by a population of cyclophosphamide-sensitive CD4- CD8+ T cells. The results further show, in contrast, that memory immunity to listeriosis, which was defined as resistance transferred by T cells harvested from infected animals that had received ampicillin chemotherapy, was shown to be mediated by cyclophosphamide-resistant CD4+ CD8- T cells.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins 80523.
authors.forename: I M
authors.initials: IM
authors.lastname: Orme
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D005260:Female; D007110:Immunity, Active; D007113:Immunity, Innate; D007116:Immunization, Passive; D007156:Immunologic Memory; D008088:Listeriosis / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens