[An algorithm for calculating and analyzing the dissociation curves of human blood oxyhemoglobin standardized by 2 and 3 allosteric ligands].
An algorithm of an "OXYHEM" programme intended for standardization of experimentally changed human blood oxyhemoglobin dissociation curves by two (H+, CO2) and three (H+, CO2, 2,3-DPG) allosteric ligands is presented. In the former case all the points of the curve are adjusted to the values of pH--7.4, pCO2--40 mmHg, while in the latter case--to values of pH--7.4, pCO2--40 mmHg and 2,3-DPG concentration 5 mmol per 1 of PBC. Every standardized curve makes it possible to determine P50, Hill's ratio, arteriovenous difference by O2 saturation and content. A comparative analysis of the parameters calculated presents a wide range of data reflecting the state of oxygen transport hemoglobin function in the studied blood.
Dmitrieva
M G
MG
Karpova
I V
IV
Tokarev
Iu N
IuN
D019794:2,3-Diphosphoglycerate; D000465:Algorithms; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D010108:Oxyhemoglobins / Q000378:metabolism*
D004163:Diphosphoglyceric Acids; D008024:Ligands; D010108:Oxyhemoglobins; D019794:2,3-Diphosphoglycerate; D002245:Carbon Dioxide
Algoritm rascheta i analiza krivykh dissotsiatsii oksigemoglobina krovi cheloveka, standartizovannykh po dvum i trem allostericheskim ligandam.