[Antibodies against the 15 amino acid sequence 599-613 of HIV-1 glycoprotein 41 in subjects at risk of HIV infection].
A peptide (called A-15) composed of 15 amino acids of the gp41 (from position 599 to position 613 of the sequence encoded by the env gene) of HIV-1 has been used as an antigen to search for antibodies in 347 sera of at-risk for HIV-1 infection subjects. The purpose was of comparing the prevalence of these antibodies with that of HIV-1 total EIA antibodies and HIV-1 immunoblotting antibodies. Assuming immunoblotting test as reference test for detecting a HIV-1 infection, the antibodies against peptide A-15 show the same sensitivity and specificity when compared with other HIV-1 total EIA antibodies tests.
Nardi
G
G
Cattedra 5 di Igiene, Università degli Studi di Milano.
Zanchetta
N
N
Maiolani
M
M
Berlusconi
A
A
Salvaggio
L
L
D000595:Amino Acid Sequence; D000918:Antibody Specificity / Q000276:immunology; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D008297:Male; D008969:Molecular Sequence Data
D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41
Anticorpi contro la sequenza aminoacida 599-613 della glicoproteina 41 dell'HIV 1 in soggetti a rischio di infezione per il virus.