Depressed plasma fibrinolytic activity in a group of patients with connective tissue diseases.
In various connective tissue disorders, a depressed fibrinolytic activity of the blood, attributed a contributory role in the development of disease, has been reported. We have determined selected fibrinolysis variables of the blood in 16 patients (7 patients with mixed connective tissue disease, 4 with systemic lupus erythematosus, 3 with rheumatoid arthritis and 2 with systemic sclerosis) and in 16 apparently healthy, age- and sex-matched controls. A significantly reduced mean activity of the intrinsic derived, urokinase-like plasminogen activator was found in the patient group. None of the other variables, including the extrinsic plasminogen activator (t-PA), differed from the control group. Possible implications of our findings in relation to the patho-physiology of these connective tissue diseases are discussed.
Munkvad
S
S
Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark.
Gram
J
J
Jespersen
J
J
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood; D003095:Collagen Diseases / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D005343:Fibrinolytic Agents / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000097:blood; D010960:Plasminogen Activators / Q000097:blood; D012595:Scleroderma, Systemic / Q000097:blood; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D005343:Fibrinolytic Agents; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator