[Corneal crystalline deposits in multiple myeloma].
Two cases of multiple myeloma with corneal opacity were reported. Their chief complaint was blurred vision, and general check-up performed prior to cataract operation revealed that one case had multiple myeloma of IgG-kappa and another, of IgG-lambda type. Two corneal buttons obtained at the time of lamellar keratoplasty operations in the IgG-kappa case were studied immunohistopathologically as well as electron microscopically. Corneal opacity observed with a slit lamp was localized at the anterior stroma of both corneas. Immunohistological studies revealed that the deposit was IgG-kappa chain. Transmission electron microscopy disclosed electron-dense extracellular deposits that exhibited a honeycomb appearance and parallel linear structures with a periodicity of 12nm.
Wakita
M
M
Kanai
A
A
Nakajima
A
A
Shirai
T
T
Saionji
K
K
D000368:Aged; D000369:Aged, 80 and over; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D003318:Corneal Opacity / Q000209:etiology / Q000378:metabolism; D003459:Crystallins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000378:metabolism*
D003459:Crystallins; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains