Outer membrane proteins of gentamicin induced small colony variants of Pseudomonas aeruginosa.
Small colony variants (SCVs) of Pseudomonas aeruginosa NCTC 6750 (WT) were repeatedly isolated in an in vitro kinetic model after exposure to gentamicin (GM). There were minor differences biochemically and in phage and serotyping between the wild type (WT) strain and SCVs. Changes in outer membrane protein profiles were found. SCVs were more resistant to polymixin and to a range of aminoglycosides (except kanamycin), but were more susceptible to a range of other antibiotics (hydrophilic and hydrophobic) with differing modes of action.
Langford
P R
PR
Department of Pharmaceutical Sciences, Aston University, Birmingham, UK.
Anwar
H
H
Gonda
I
I
Brown
M R
MR
D001425:Bacterial Outer Membrane Proteins / Q000032:analysis*; D014644:Genetic Variation; D005839:Gentamicins / Q000493:pharmacokinetics*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics
D001425:Bacterial Outer Membrane Proteins; D005839:Gentamicins