[Clinical significance of apolipoprotein B and AI determinations in coronary heart disease].
In this report, the relative validity of serum apolipoprotein (apo) B and AI analyses in the discrimination of coronary heart disease (CHD) was evaluated, and compared with the results of serum triglyceride (TG) total cholesterol, low density and high density lipoprotein cholesterol (HDL-C) determinations. 101 cases of CHD, 95 cases of myocardial infarction survivors (MIS) and 177 cases of acute myocardial infarction (AMI) were studied, with a control group including 266 age and sex matched healthy subjects. The results of monovariant statistics showed that apo B had highest percentage of positive results, and TG had most prominent elevation of mean values in CHD and MIS groups. Both multivariant stepwise discrimination and logistic regression analyses demonstrated the superiority of HDL-C, apo B and apo AI in detecting CHD in men; while in female subjects, apo B remained as the best discriminator, but apo AI and HDL-C lost its statistic significance. The quantitative relationships among apo AI, HDL-C and TG were discussed briefly. Since the decrease in HDL-C level in CHD were mainly due to hypertriglyceridemia, the significance of high TG level in correlation with CHD should not be neglected. AII serum lipids and apo B AI levels were decreased in AMI cases, and reached lowest values after 7 days. But the level of these variables were not changed significantly within 48 hours after onset of the episode. There was no frank correlation between the degree of serum lipid lowering and prognosis of AMI.
Li
J Z
JZ
Wang
J J
JJ
Niu
Q T
QT
D000368:Aged; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D014280:Triglycerides