Association of class I, II, and III MHC gene products with systemic lupus erythematosus. Results of a Central European multicenter study.
Class I, II, and III MHC gene products were examined in 248 Central European SLE patients. The previously reported association with HLA-A1, -B8 and -DR3, and C4AQ0 alleles was confirmed. The frequency of HLA-DR2 was also slightly elevated in SLE patients, while no increase in C4BQ0 alleles was observed. Additional findings were a significantly increased frequency of HLA-B13 and a significant decrease of HLA-B44.
Hartung
K
K
Department of Medicine, Universities of Bern, Switzerland.
Fontana
A
A
Klar
M
M
Krippner
H
H
Jörgens
K
K
Lang
B
B
Peter
H H
HH
Pichler
W J
WJ
Schendel
D
D
Robin-Winn
M
M
D000483:Alleles; D005060:Europe; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex; D015337:Multicenter Studies as Topic
D006680:HLA Antigens