title: Ovulation induction with pulsatile administration of human menopausal gonadotropin.
abstract: Ovulation induction was performed by the pulsatile administration of subcutaneous human menopausal gonadotropin (hMG). Treatment was started with a daily dose of 75 IU hMG (in a 90% distribution), then it was increased to 150 IU depending on the oestradiol level of the plasma and on the result of folliculometry. Of 10 cycles treated ovulation was induced in 7 cases and two pregnancies occurred. In two cases, following a previous unsuccessful intramuscular hMG treatment, ovulation was induced. Hyperstimulation did not occur. The pulsatile s.c. administration of hMG seems to be an adequate ovulation-induction method in ovulatory disorders of hypothalamo-hypophyseal origin and is a good substitute for the missing, endogenous gonadotropin secretion of inadequate pace.
authors.affiliation: Department of Obstetrics and Gynaecology, Szent-Györgyi Albert University Medical School, Szeged, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Koloszár
authors.forename: G
authors.initials: G
authors.lastname: Bártfai
authors.forename: G
authors.initials: G
authors.lastname: Godó
authors.forename: M
authors.initials: M
authors.lastname: Sas
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D007260:Infusion Pumps; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000097:blood; D011673:Pulsatile Flow
chemical_list: D011374:Progesterone; D008596:Menotropins