Possible relationship between poly(ADP-ribose)synthetase and formation of antibody against acetylcholine receptors in patients with myasthenia gravis.
We examined the relationship of the serum levels of antibody against acetylcholine receptors to the serum levels of 13 enzymes, including various hydrolytic enzymes, poly(ADP-ribose)synthetase (Poly(ADP-ribose)Syn), and sialyltransferase (NANA-trans), in patients with myasthenia gravis. The patients were divided into two groups, depending on the presence or absence of thymoma. In spite of the absence of significant difference in the absolute levels of individual enzymatic activities between the two groups, the network relationships of such enzymes were quite different between the two groups. Of the 13 enzymes examined, only Poly(ADP-ribose)Syn showed a weak but significant correlation with the level of the antibody in the patients without thymoma. A multivariate study more clearly suggested the relationship between the antibody formation and Poly(ADP-ribose)Syn in the patients without thymoma. Such observations were not found in the patients with thymoma.
Aoyagi
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Wada
T
T
Kojima
F
F
Nagai
M
M
Yoshida
S
S
Sato
T
T
Takeuchi
T
T
D001323:Autoantibodies / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009157:Myasthenia Gravis / Q000201:enzymology* / Q000209:etiology / Q000276:immunology; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000276:immunology*; D013945:Thymoma / Q000150:complications / Q000201:enzymology; D013953:Thymus Neoplasms / Q000150:complications / Q000201:enzymology
D001323:Autoantibodies; D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011950:Receptors, Cholinergic; D011065:Poly(ADP-ribose) Polymerases