High performance liquid chromatographic determination of fluvoxamine in human plasma.
A method has been developed for the separation and measurement of fluvoxamine in human plasma by high performance liquid chromatography. The method uses metapramine as an internal standard and provides a limit of detection of about 1.5 ng/mL for fluvoxamine. At a concentration of 25 ng/mL, fluvoxamine could be measured within a coefficient of variation of +/- 5.82 of the mean and at 100 ng/mL within a CV of +/- 2.78 of the mean. The method has been applied to the analysis of plasma from patients undergoing fluvoxamine therapy.
Pommery
J
J
Laboratoire de Toxicologie, Faculte de Pharmacie, Lille, France.
Lhermitte
M
M
D000928:Antidepressive Agents / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D016666:Fluvoxamine; D006801:Humans; D010091:Oximes / Q000097:blood* / Q000493:pharmacokinetics; D013050:Spectrometry, Fluorescence
D000928:Antidepressive Agents; D010091:Oximes; D016666:Fluvoxamine