Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T.
Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer 51Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.
Kent
T A
TA
Department of Neurology, University of Texas Medical Branch, Galveston 77550.
Quast
M J
MJ
Kaplan
B J
BJ
Najafi
A
A
Amparo
E G
EG
Gevedon
R M
RM
Salinas
F
F
Suttle
A D
AD
DiPette
D J
DJ
Eisenberg
H M
HM
D000818:Animals; D001810:Blood Volume; D001812:Blood-Brain Barrier; D002545:Brain Ischemia / Q000503:physiopathology*; D002199:Capillary Permeability; D002536:Cerebral Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin
D003287:Contrast Media; D009942:Organometallic Compounds; D012709:Serum Albumin; D004369:Pentetic Acid; D019786:Gadolinium DTPA