Synthesis, properties and prodrug potential of 2-methyl-2-oxy- and 2-methyl-2-thio-4H-1,3-benzodioxin-4-ones.
The fifty-four known title compounds are fully documented and their chemical and biological properties discussed in detail. Special attention is devoted to their potential as aspirin and salicylic acid prodrugs, respectively.
Ankersen
M
M
Department of Chemistry, University of Aarhus, Denmark.
Nielsen
K K
KK
Senning
A
A
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives*; D001592:Benzyl Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004147:Dioxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006868:Hydrolysis; D008958:Models, Molecular; D015394:Molecular Structure; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012459:Salicylates; D020156:Salicylic Acid
D001592:Benzyl Alcohols; D004147:Dioxins; D011355:Prodrugs; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin