Sodium cromoglycate: a review.
Sodium cromoglycate is a drug widely used in the treatment of bronchial asthma. In vitro and animal models show that its effect is related to mast cell stabilization and to a direct action on inflammatory cells or the broncho-obstructive reflex. In man, sodium cromoglycate is able to prevent bronchoconstriction induced by a variety of stimuli including the 'late' reaction to allergen. It is also able to prevent the allergen-induced increase in hyperresponsiveness. Long-term therapeutic trials have confirmed its validity in the treatment of asthmatic patients.
Patalano
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F
Medical Department, Fisons Farmaceutici S.p.A., Rome, Italy.
Ruggieri
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F
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D004205:Cromolyn Sodium / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008407:Mast Cells / Q000187:drug effects
D004205:Cromolyn Sodium