title: Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression.
abstract: Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: D M
authors.initials: DM
authors.lastname: Nanus
authors.forename: S A
authors.initials: SA
authors.lastname: Ebrahim
authors.forename: N H
authors.initials: NH
authors.lastname: Bander
authors.forename: F X
authors.initials: FX
authors.lastname: Real
authors.forename: L M
authors.initials: LM
authors.lastname: Pfeffer
authors.forename: J R
authors.initials: JR
authors.lastname: Shapiro
authors.forename: A P
authors.initials: AP
authors.lastname: Albino
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002455:Cell Division; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002891:Chromosomes, Human, Pair 21; D005732:Gangliosides / Q000276:immunology; D011905:Genes, ras; D006133:Growth Substances / Q000096:biosynthesis; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000276:immunology / Q000473:pathology; D010641:Phenotype; D012190:Retroviridae / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D005732:Gangliosides; D006133:Growth Substances