The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis.
Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid. No clinical improvement was noted in any subject after treatment by either drug.
Mallet
A I
AI
Institute of Dermatology, St Thomas' Hospital, United Medical School, London.
Norris
P
P
Rendell
N B
NB
Wong
E
E
Greaves
M W
MW
D000328:Adult; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006632:Histamine / Q000652:urine*; D006801:Humans; D007093:Imidazoles / Q000652:urine*; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D008415:Mastocytosis / Q000188:drug therapy* / Q000652:urine; D008875:Middle Aged
D007093:Imidazoles; C002667:methylimidazoleacetic acid; D006632:Histamine; D004205:Cromolyn Sodium; D007665:Ketotifen