[Lymphocyte subsets and interleukin-2 (IL-2) production of peripheral blood lymphocytes in patients with Vogt-Koyanagi-Harada disease].
The lymphocyte subsets and the interleukin-2 (IL-2) production of peripheral blood lymphocytes (PBL) in patients with Vogt-Koyanagi-Harada Disease (V.K.H.) were studied. In PBL, increased percentages of CD4+ T cells and decreased percentages of CD8+ T cells, which lead to high CD4/CD8 ratio were observed. In the CD4+ T cells the percentage of CD4+ 2H4+ T cells and CD4+ DR+ T cells increased. PBL from 3 out of 9 cases with V.K.H. produced high amount of IL-2 in vitro after stimulation with PHA, indicating IL-2 might be related to the pathogenesis of V.K.H. The differences of the phenotypes of PBL and IL-2 production in vitro between the patients in the acute and prolonged stages were not demonstrated. These results suggest that CD4+ T cells, especially CD4+ 2H4+ T cells may play an important role in the pathological feature of V.K.H.
Iwata
M
M
Kitano
S
S
Sawada
S
S
Nishinarita
S
S
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D014605:Uveitis / Q000276:immunology*; D014607:Uveomeningoencephalitic Syndrome / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D007376:Interleukin-2