title: [Determination of copper in hepatic tissue for the diagnosis of Wilson's disease].
abstract: Three young patients had clinical data compatible with Wilson's disease (WD); all of them had high serum levels of ceruloplasmin without Kayser-Fleischer rings (K-F), the urinary copper level being very low, not supporting the Wilson's disease diagnosis. This reason was why we decided to detect the amount of copper in the liver tissue, which was very high in all patients, confirming the disease. We would comment that WD of abdominal type does not usually have the K-F rings, which made the diagnosis difficult. An algorithm is proposed to be applied in each case were WD is suspected.
authors.forename: R
authors.initials: R
authors.lastname: Bataller Sifre
authors.forename: A
authors.initials: A
authors.lastname: Peydro Olaya
authors.forename: M
authors.initials: M
authors.lastname: Arroyo Vicente
authors.forename: R M
authors.initials: RM
authors.lastname: Bataller Alberola
authors.forename: C
authors.initials: C
authors.lastname: Carda Batalla
authors.forename: R
authors.initials: R
authors.lastname: Broseta Aguado
mesh_terms: D000293:Adolescent; D000328:Adult; D003300:Copper / Q000032:analysis*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000737:chemistry*; D008297:Male
chemical_list: D003300:Copper
vernacular_title: Determinación de cobre en tejido hepático para el diagnóstico de la enfermedad de Wilson.