Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.
(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.
Fujita
Y
Y
Department of Surgery, Fukuchiyama National Hospital, Kyoto.
Yamane
T
T
Tanaka
M
M
Kuwata
K
K
Okuzumi
J
J
Takahashi
T
T
Fujiki
H
H
Okuda
T
T
D000818:Animals; D002273:Carcinogens; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives*; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure
D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; C013525:ENNG; D002392:Catechin; C045651:epigallocatechin gallate