Theophylline disposition in patients with COLD with and without hypoxemia.
This study aimed to assess the effect of hypoxemia on theophylline disposition. Ten patients with a mean (+/- SEM) of 58 +/- 3 years with COLD (PaO2 55 +/- 1 mm Hg, PaCO2 46 +/- 2 mm Hg, and pH of 7.39 +/- 0.01) were hospitalized to have oxygen therapy. Before starting O2, they received intravenously, 4 mg/kg of theophylline over a 20-minute period; blood samples and urine were collected for six hours. The results suggested that hypoxia does not influence the disposition of theophylline or its metabolites.
du Souich
P
P
INSERM U. 14, Vandoeuvre-lès-Nancy, France.
Hoen
B
B
Saunier
C
C
Hartemann
D
D
Sautegeau
A
A
Cornette
A
A
Delorme
N
N
Polu
J M
JM
Sadoul
P
P
D001711:Biotransformation; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D002245:Carbon Dioxide; D013806:Theophylline; D010100:Oxygen