title: Histomorphometric evaluation of stress shielding in mandibular continuity defects treated with rigid fixation plates and bone grafts.
abstract: Histomorphometric techniques were used to evaluate the stress shielding effect in bilateral bone grafts in 4 Macaca fascicularis monkeys. Bilateral continuity defects were created and grafted by replacing the resected portion of the mandible and iliac crest bone into the defect area. Both sides were plated with rigid internal fixation plates. Three months after bone grafting, the plate was removed from one side while the other plate was left in place. The animals were sacrificed at 1, 4, 6, and 8 months after plate removal and the grafted areas removed for histomorphometric analysis. This study documents decreased bone volume as well as smaller interlabel width on the plated side, suggesting a stress shielding effect as a result of the rigid internal fixation plate.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of North Carolina.
authors.forename: M C
authors.initials: MC
authors.lastname: Kennady
authors.forename: M R
authors.initials: MR
authors.lastname: Tucker
authors.forename: G E
authors.initials: GE
authors.lastname: Lester
authors.forename: M J
authors.initials: MJ
authors.lastname: Buckley
mesh_terms: D000818:Animals; D001860:Bone Plates; D016025:Bone Transplantation; D005069:Evaluation Studies as Topic; D007091:Image Processing, Computer-Assisted; D008252:Macaca fascicularis; D008334:Mandible / Q000033:anatomy & histology* / Q000502:physiology / Q000601:surgery; D008336:Mandibular Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008856:Microscopy, Fluorescence; D010012:Osteogenesis; D010865:Pilot Projects; D013314:Stress, Mechanical; D013752:Tetracycline
chemical_list: D013752:Tetracycline