title: Arachidonic acid transformation is not stimulated in delayed pressure urticaria.
abstract: Little is known about the molecular mechanisms or inflammatory mediators involved in delayed pressure urticaria (DPU). Pressure sufficient to provoke lesions was applied to the back of six patients with DPU. The levels of products of arachidonic acid transformation in skin exudate from the pressure challenged skin were estimated immediately after pressure was removed and 6 h later when lesions were present. These were compared to levels estimated in a similar way from unchallenged skin in these patients. Levels of leukotriene C4/D4/E4, prostaglandin E2, 12-hydroxyeicosatetraenoic acid and leukotriene B4 were not raised in lesional skin. Our results suggest that arachidonic acid metabolism is not stimulated in DPU.
authors.affiliation: Institute of Dermatology, St Thomas's Hospital, London, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Lawlor
authors.forename: R
authors.initials: R
authors.lastname: Barr
authors.forename: A
authors.initials: A
authors.lastname: Kobza-Black
authors.forename: O
authors.initials: O
authors.lastname: Cromwell
authors.forename: J
authors.initials: J
authors.lastname: Isaacs
authors.forename: M
authors.initials: M
authors.lastname: Greaves
mesh_terms: D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D015289:Leukotrienes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011312:Pressure / Q000009:adverse effects; D012867:Skin / Q000378:metabolism*; D014581:Urticaria / Q000209:etiology / Q000378:metabolism*
chemical_list: D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D016718:Arachidonic Acid; D015232:Dinoprostone