Effects of parathyroid hormone on urinary excretion of N-acetyl-beta-D-glucosaminidase in idiopathic hypoparathyroidism and pseudohypoparathyroidism.
N-acetyl-beta-D-glucosaminidase (NAG) is a lysosomal enzyme predominantly located in renal proximal tubules. In idiopathic hypoparathyroidism (IHP), 100 Units of human PTH (1-34) increased urinary excretion of NAG from 0.029 +/- 0.027 to 0.173 +/- 0.035 U/lGF (p less than 0.05) in two patients before treatment and from 0.025 +/- 0.004 to 0.189 +/- 0.092U/lGF (p less than 0.02) in four patients during treatment with active vitamin D3 (1,25(OH)2D3 or 1 alpha OHD3). In pseudohypoparathyroidism (PHP), PTH did not significantly increase the urinary excretion of NAG in one patient with before treatment (0.048 to 0.025 U/lGF) and four patients during treatment with active vitamin D3 (0.018 +/- 0.008 to 0.036 +/- 0.015 U/lGF). Increase in urinary excretion of NAG after injection of PTH may be a new indicator of renal effect of PTH.
Mizunashi
K
K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Furukawa
Y
Y
Taguchi
K
K
Kuwahara
M
M
Miura
R
R
Yumita
S
S
Yoshinaga
K
K
D000118:Acetylglucosaminidase / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006596:Hexosaminidases; D006801:Humans; D007037:Hypothyroidism / Q000201:enzymology / Q000209:etiology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011547:Pseudohypoparathyroidism / Q000201:enzymology / Q000652:urine*; D014554:Urination / Q000187:drug effects*
D010281:Parathyroid Hormone; D006596:Hexosaminidases; D000118:Acetylglucosaminidase