The efficacy of nifedipine and acebutolol in coronary artery disease assessed by radionuclide ventriculography.
The efficacy of a fixed combination of 10 mg nifedipine and 100 mg acebutolol was tested in 21 patients with angiographically proven coronary artery disease (CAD). Ejection fraction (EF), emptying and filling rate (VS and VD), and end-systolic volume (ESV) were assessed by means of radionuclide ventriculography at rest and during exercise prior to as well as 1 hour and 5 hours following oral drug application. Whereas exercise-induced worsening of cardiac function had been documented in all the patients prior to medication, EF and ESV improved significantly after drug administration.
Bauer
R
R
Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universität München, FRG.
Busch
U
U
Lutilsky
L
L
van de Flierdt
E
E
Langhammer
H R
HR
Pabst
H W
HW
D000070:Acebutolol / Q000008:administration & dosage*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004338:Drug Combinations; D005080:Exercise Test / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D015635:Radionuclide Ventriculography
D004338:Drug Combinations; D000070:Acebutolol; D009543:Nifedipine