[Possibilities of restoring the glial population of the neocortex after protein-energy insufficiency].
The aim of the work was to estimate reversibility degree, as well as possibilities of correction of the disturbances in formation of glial population in mouse neocortex, that occur under effect of insufficient nutrition. The work was performed on SBA mice. The protein-energetic insufficiency was produced by means of feeding to the animals a synthetic starch-casein diet with a twice reduced (in comparison with the control) content of the nutritional substances (5% of protein). The scheme of the experiment: the I group--mice undernourished from the 10th up to the 40th day, from the 40th up to the 70th day of life they were given normal feeding; in the II group to the normal diet during the period of food rehabilitation carnitine was added in the dose 0.5 mg/g of the body mass. 70-day-old mouse kept at the full-bodied diet served as the control. Quantitative and qualitative analyse of the glial population composition was performed in semithin araldit slices of the parietal cerebral cortex. During the period of food rehabilitation oligodendrocytes fully restore their amount, however, amount of mature oligodendrocytes is lower than normal. After rehabilitation the part of the perineuronal glia by 19%, and after rehabilitation with carnitine--by 36% higher than in the cerebral cortex of the control animals.
Medvedev
D I
DI
Savrova
O B
OB
Iakovleva
T V
TV
D000818:Animals; D002452:Cell Count; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D051379:Mice; D008808:Mice, Inbred CBA; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000473:pathology* / Q000502:physiology; D010296:Parietal Lobe / Q000473:pathology*; D011502:Protein-Energy Malnutrition / Q000178:diet therapy / Q000473:pathology*
D004044:Dietary Proteins
Vozmozhnosti vosstanovleniia glia'lnoĭ populiatsii neokorteksa posle belkovo-énergeticheskoĭ nedostatochnosti.