Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.
The human pan-leukocyte antigen Leu-8 has attracted wide interest because its presence or absence identifies suppressor-inducer and helper-inducer CD4+ T-lymphocyte subsets respectively. We report here that Leu-8 is the human homologue of the mouse Mel-14 homing receptor, a molecule that promotes the initial adhesion of blood-borne lymphocytes to the specialized post-capillary endothelium of peripheral lymph nodes. We also show that Leu-8 can adopt both conventional and phospholipid anchored forms, a finding that may have relevance in the context of antigen shedding following activation or homing. The assignment of lymphocytes to different functional classes based on lymph node homing potential may represent a more general association between lymphocyte function and tissue distribution.
Camerini
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Department of Molecular Biology, Massachusetts General Hospital, Boston.
James
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SP
Stamenkovic
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I
Seed
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D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D016827:CD8 Antigens; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D021382:Protein Sorting Signals / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D016201:Receptors, Lymphocyte Homing; D012689:Sequence Homology, Nucleic Acid; D014162:Transfection
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D016827:CD8 Antigens; D021382:Protein Sorting Signals; D011971:Receptors, Immunologic; D016201:Receptors, Lymphocyte Homing; D004247:DNA