[Autoantibodies to different layers of epidermis during immunization of BALB/c mice with a culture of Group A Streptococcus treated with pepsin].
As revealed in the indirect immunofluorescence test, antibodies to the cross-reacting group A streptococcal polysaccharide determinant (A-PS), common to the antigen of the basal cell layer of the epidermis, regularly occur at the end of the first cycle and disappear after further immunization of BALB/c mice with the pepsin-treated culture of group A streptococci. This model may be used for the study of antibodies to A-PS, cross-reacting with the cells of the basal layer of the epidermis, in the development of the autoimmune process linked++ with group A streptococcal infection.
Bazanova
E A
EA
Gnezditskaia
E V
EV
Borodiiuk
N A
NA
Pyt'eva
E Iu
EIu
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D004817:Epidermis / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010434:Pepsin A / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D001323:Autoantibodies; D011135:Polysaccharides, Bacterial; D010434:Pepsin A
Autoantitela k razlichnym sloiam épidermisa pri immunizatsii mysheĭ linii BALB/c kul'turoĭ Streptokokka gruppy A, obrabotannoĭ pepsinom.