title: Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses.
abstract: The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lomefloxacin's elimination.
authors.affiliation: Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
authors.forename: J
authors.initials: J
authors.lastname: Kavi
authors.forename: J
authors.initials: J
authors.lastname: Stone
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: J P
authors.initials: JP
authors.lastname: Ashby
authors.forename: R
authors.initials: R
authors.lastname: Wise
mesh_terms: D042462:4-Quinolones; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects; D024841:Fluoroquinolones; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D009343:Neisseria / Q000187:drug effects; D015363:Quinolones; D014018:Tissue Distribution
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin