IgG subclasses of antibodies to the collagen-like region of C1q in patients with systemic lupus erythematosus.
Low molecular weight C1q-binding IgG in the sera of patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q. In this study, the IgG subclass distribution of these autoantibodies was examined by radial immunodiffusion with polyclonal antibodies specific for each subclass. The purified antibodies to the collagen-like region of C1q possessed the IgG subclass distribution present in normal serum.
Uwatoko
S
S
Department of Medicine, University of Washington, Seattle.
Mannik
M
M
D000906:Antibodies / Q000032:analysis* / Q000145:classification; D003094:Collagen / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D000906:Antibodies; D007074:Immunoglobulin G; D015922:Complement C1q; D003094:Collagen