Chronic L-deprenyl-induced up-regulation of the dopamine uptake carrier.
L-Deprenyl is an inhibitor of monoamine oxidase B and dopamine uptake. Chronic L-deprenyl (10 mg/kg i.p., twice weekly for 4 weeks) was shown to inhibit monoamine oxidase B activity by 89%, and also to induce an up-regulation of the [3H]mazindol binding site associated with the striatal dopamine uptake carrier. Scatchard analysis indicated a 56% increase in the maximal number of [3H]mazindol binding sites in chronic L-deprenyl animals, but no effect on the affinity of these binding sites. The ability of L-deprenyl to up-regulate the [3H]mazindol-associated dopamine uptake carrier appears to be a result of its role as a dopamine uptake inhibitor.
Wiener
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HL
Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Ward's Island, NY 10035.
Hashim
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Lajtha
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Sershen
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D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008454:Mazindol / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008995:Monoamine Oxidase / Q000378:metabolism; D010627:Phenethylamines / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects*; D012642:Selegiline / Q000494:pharmacology*
D002395:Catecholamines; D010627:Phenethylamines; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D012642:Selegiline; D008454:Mazindol; D008995:Monoamine Oxidase; C001746:3-methoxytyramine; D004298:Dopamine