The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis.
The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.
Wainer
I W
IW
Pharmaceutical Division, St. Jude Children's Research Hospital, Memphis, TN 38101.
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D002955:Leucovorin / Q000097:blood; D013237:Stereoisomerism; D013726:Terbutaline / Q000097:blood; D014859:Warfarin / Q000097:blood
D014859:Warfarin; D013726:Terbutaline; D002955:Leucovorin