title: Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects.
abstract: The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half-lives, areas under the plasma concentration-time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.
authors.affiliation: Laboratoire de Pharmacologie et de Biochimie, Centre Hospitalier de Versailles, France.
authors.forename: N
authors.initials: N
authors.lastname: Brion
authors.forename: E
authors.initials: E
authors.lastname: Naline
authors.forename: D
authors.initials: D
authors.lastname: Beaumont
authors.forename: M
authors.initials: M
authors.lastname: Pays
authors.forename: C
authors.initials: C
authors.lastname: Advenier
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D016593:Terfenadine; D013806:Theophylline / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D013997:Time Factors; D014527:Uric Acid / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine; D014970:Xanthines / Q000097:blood / Q000652:urine
chemical_list: D001559:Benzhydryl Compounds; D014970:Xanthines; D014527:Uric Acid; C008514:methylxanthine; C030530:1-methyluric acid; D016593:Terfenadine; D013806:Theophylline; C031274:1,3-dimethyluric acid