T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals.
We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and immunoblot methods. Histologic sections from each patient showed a high-grade pleomorphic T-cell non-Hodgkin lymphoma, and immunophenotyping demonstrated a prevalence of reactivity for CD4 (helper) over CD8 (suppressor) antigens. T-cell receptor beta-chain gene rearrangement studies revealed a rearranged pattern with either the HindIII or BamHI enzymes, whereas immunoglobulin heavy chain genes retained a germ-line configuration. Viral sequences specific for human T-cell leukemia virus-I, human T-cell leukemia virus-II, or HIV-1 were not detected. Thus, although rare, T-cell non-Hodgkin lymphoma may be observed in HIV-1-infected individuals.
Lust
J A
JA
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Banks
P M
PM
Hooper
W C
WC
Paya
C V
CV
Kueck
B D
BD
Hanson
G A
GA
Ritch
P S
PS
Woloschak
G E
GE
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D015497:HIV-1 / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000502:physiology; D015367:Human T-lymphotropic virus 2 / Q000502:physiology; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D007159:Immunologic Tests; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes
D007148:Immunoglobulin mu-Chains