title: Primary hypercoagulable states in general and vascular surgery.
abstract: Primary hypercoagulable states are increasingly recognized as causes of venous and arterial thromboembolism in surgical patients. Herein, we describe 10 patients with this syndrome who were diagnosed during a recent 1-year period. A family history and past medical history of thromboembolism and an unusual site of thrombosis are emphasized for accurate diagnosis. Although antithrombin III deficiencies were the most common abnormality found, we describe three patients with hypofibrinolytic syndromes and increased levels of tissue plasminogen activator inhibitor. The effectiveness of anticoagulation therapy in preventing recurrent thromboembolism is stressed.
authors.affiliation: University of Kansas College of Health Sciences, Kansas City.
authors.forename: J H
authors.initials: JH
authors.lastname: Thomas
authors.forename: G E
authors.initials: GE
authors.lastname: Pierce
authors.forename: R
authors.initials: R
authors.lastname: Delcore
authors.forename: D C
authors.initials: DC
authors.lastname: Bodensteiner
authors.forename: J I
authors.initials: JI
authors.lastname: Iliopolous
authors.forename: A S
authors.initials: AS
authors.lastname: Hermreck
mesh_terms: D000293:Adolescent; D000328:Adult; D020152:Antithrombin III Deficiency; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D015849:Plasminogen Inactivators / Q000097:blood; D011183:Postoperative Complications; D020151:Protein C Deficiency; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000097:blood; D014656:Vascular Surgical Procedures
chemical_list: D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator