[The antiproliferative effects associated with vincristine and human interferons in experimental in vitro systems].
Cytotoxic potential of suboptimal doses of vincristine associated with human interferon was studied in two cell lines of tumoral origin, as compared to the action of or gamma type interferon preparations. Results show that the vincristine cytotoxic effect may be synergistically augmented in both culture types by simultaneous interferon administration.
Danielescu
G
G
Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
Maniu
H
H
Jucu
V
V
Cajal
N
N
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000627:therapeutic use*
D007370:Interferon Type I; D014750:Vincristine; D007371:Interferon-gamma
Effets antiprolifératifs associés du vincristine et des interférons humains dans des systèmes expérimentaux in vitro.