title: Digoxin-like substance in the serum of uremic patients before and after hemodialysis.
abstract: Digoxin concentrations in serum samples were measured before and after hemodialysis of 31 uremic patients (pts) who either never took digoxin or who had not taken digoxin for at least 1 year. False positive digoxin was found in 22 of 31 patients (71%) before hemodialysis and in 14 of 31 patients (45%) after hemodialysis. The concentrations ranged from 0.1 to 0.5 nmol/L, mean value was 0.20 +/- 0.16 before hemodialysis and after hemodialysis ranged 0.1 to 0.4 nmol/L mean value was 0.11 +/- 0.14 nmol/L. The difference before and after hemodialysis is statistically significant. Some of the patients had a constant value before and after hemodialysis. None had a higher value after hemodialysis than they did before. Eight patients, who had positive serum digoxin before hemodialysis with concentrations up to 0.5 nmol/L, became negative after hemodialysis. Our results indicate that a digoxinlike substance in uremic serum could be at least partly dialyzable.
authors.affiliation: University Hospital, Department of Medicine, Zagreb, Yugoslavia.
authors.forename: Z
authors.initials: Z
authors.lastname: Durakovic
authors.forename: D
authors.initials: D
authors.lastname: Ivanovic
authors.forename: A
authors.initials: A
authors.lastname: Durakovic
mesh_terms: D000293:Adolescent; D000328:Adult; D004077:Digoxin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D004077:Digoxin