title: Rates of triolein absorption in suckling and adult rats.
abstract: To determine the extent to which suckling animals differ from adults in their capacity to absorb fat, we compared the rate of absorption of orally administered [14C]triolein in 11- to 12-day-old suckling rats with that of 10-wk-old adults by three distinct methods. In the first, the rate of [14C]triolein disappearance was determined by quantitating substrate remaining in the gastrointestinal tract after oral administration. In the second, 14CO2 expiration in breath was measured continuously for 6 h after an identical feeding. In the third, intestinal triglyceride output was estimated by the lipoprotein lipase inhibitor, Triton WR-1339. Triolein disappearance, 14CO2 excretion, and intestinal triglyceride output were two- to threefold higher in suckling rats compared with adults (P less than 0.01, P less than 0.0001, and P less than 0.01, respectively). There was also a highly significant linear relationship between 14CO2 excretion and both triolein disappearance and intestinal triglyceride output for both age groups (P less than 0.0001 and P less than 0.003, respectively). These data show that consistent with its high dietary intake, the suckling rat can absorb triolein at rates significantly higher than the adult.
authors.affiliation: Department of Pediatrics, University of Arizona College of Medicine, Tucson 85724.
authors.forename: C A
authors.initials: CA
authors.lastname: Flores
authors.forename: S A
authors.initials: SA
authors.lastname: Hing
authors.forename: M A
authors.initials: MA
authors.lastname: Wells
authors.forename: O
authors.initials: O
authors.lastname: Koldovský
mesh_terms: D000042:Absorption; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D002245:Carbon Dioxide; D007413:Intestinal Mucosa / Q000378:metabolism; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D014280:Triglycerides / Q000378:metabolism; D014304:Triolein / Q000493:pharmacokinetics*
chemical_list: D014280:Triglycerides; D014304:Triolein; D002245:Carbon Dioxide; D011092:Polyethylene Glycols; C016811:tyloxapol