Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs.
The absolute concentrations of chondroitin 4- and 6-sulfate are compared in articular and endochondral ossification cartilage from normal dogs. In newborn dogs, the absolute concentration of chondroitin 4-sulfate decreases nearly 3-fold from the deeper endochondral ossification cartilage to the articular surface, whereas that of chondroitin 6-sulfate does not change. In cartilage from the articular surface of the epiphysis in adults, where the ossification process is complete, the concentration of chondroitin 4-sulfate is also low. These observations suggest that chondroitin 4-sulfate may be important in the ossification process. The pathogenesis of heritable disorders involving the sulfation of chondroitin sulfate is discussed in view of these findings.
Harab
R C
RC
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
Mourão
P A
PA
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism / Q000502:physiology; D002356:Cartilage / Q000378:metabolism* / Q000502:physiology; D002358:Cartilage, Articular / Q000378:metabolism / Q000502:physiology; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D004285:Dogs; D006025:Glycosaminoglycans / Q000378:metabolism; D006603:Hexuronic Acids / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D010012:Osteogenesis
D006025:Glycosaminoglycans; D006603:Hexuronic Acids; D002807:Chondroitin; D002809:Chondroitin Sulfates; D006909:Hydroxyproline