title: Genetics of antibody responsiveness to bovine serum albumin and rabbit gamma-globulin. II. Evidence for a partially common genetic regulation of response to bovine serum albumin and rabbit gamma-globulin.
abstract: In order to measure the reciprocal nonspecific effect of the genetic regulation of antibody responsiveness to bovine serum albumin (BSA) and rabbit gamma-globulin (RGG), two independent bidirectional selective breedings for responses to these two antigens were carried out: selection V/BSA and selection V/RGG respectively. The total interline separation at selection limit (RT) was 5.3 log2 for selection V/BSA and 2.6 log2 for selection V/RGG. The sum of these two values (7.9 log2) is similar to the RT in selection V carried out by alternating these two antigens in consecutive generations. In selection V/BSA, the nonspecific effect for responsiveness to RGG was 72%. In selection V/RGG, the nonspecific effect for BSA responsiveness was 135%. The F1 hybrids between homologous lines of selection V/BSA and selection V/RGG presented a larger difference in antibody response to both antigens than their parental lines. This demonstrates an additive effect of the loci controlling the two responses.
authors.affiliation: Seçao de Imunologia, Instituto Biologico, São Paulo, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Gennari
authors.forename: M H
authors.initials: MH
authors.lastname: Reis
authors.forename: V C
authors.initials: VC
authors.lastname: Ferreira
authors.forename: M
authors.initials: M
authors.lastname: Siqueira
authors.forename: D
authors.initials: D
authors.lastname: Mouton
authors.forename: G
authors.initials: G
authors.lastname: Biozzi
mesh_terms: D000818:Animals; D000906:Antibodies / Q000235:genetics*; D000917:Antibody Formation; D001947:Breeding; D002417:Cattle; D005786:Gene Expression Regulation; D005802:Genes, MHC Class II; D051379:Mice / Q000235:genetics* / Q000276:immunology; D011817:Rabbits; D012641:Selection, Genetic; D012710:Serum Albumin, Bovine / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology*
chemical_list: D000906:Antibodies; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine