title: Risk factors for coronary artery disease: a study comparing hypercholesterolaemia and hypertriglyceridaemia in angiographically characterized patients.
abstract: Fifty-two male patients undergoing coronary angiography were allocated to four groups each consisting of 13 subjects: group I had normal coronary arteries and patients in groups II-IV exhibited coronary artery disease. In group II, plasma cholesterol was below 250 mg dl-1 and triglycerides below 160 mg dl-1; in group III, cholesterol was above 270 mg dl-1 and triglycerides under 160 mg dl-1; and in group IV, cholesterol was under 270 mg dl-1 and triglycerides above 180 mg dl-1. The hypertriglyceridaemic group IV had the highest coronary score. In addition, it had lowest lipoprotein lipase activity, lowest HDL-cholesterol and lowest high-density lipoproteins-2 (HDL-2) levels, suggesting that this type of hypertriglyceridaemia is caused--at least in part--by lipoprotein lipase deficiency with impaired removal of the triglyceride-rich lipoproteins and increased catabolism of HDL-2. Our findings point towards a type of hypertriglyceridaemia strongly associated with coronary artery disease which should therefore be treated accordingly.
authors.affiliation: Department of Internal Medicine, University of Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Breier
authors.forename: J R
authors.initials: JR
authors.lastname: Patsch
authors.forename: V
authors.initials: V
authors.lastname: Mühlberger
authors.forename: H
authors.initials: H
authors.lastname: Drexel
authors.forename: E
authors.initials: E
authors.lastname: Knapp
authors.forename: H
authors.initials: H
authors.lastname: Braunsteiner
mesh_terms: D000328:Adult; D000368:Aged; D000790:Angiocardiography; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D015228:Hypertriglyceridemia / Q000097:blood / Q000145:classification / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol