A comparison of electroconvulsive therapy with a combined lithium and tricyclic combination among depressed tricyclic nonresponders.
Thirty severely depressed patients who were resistant to tricyclic antidepressant therapy were randomly allocated to treatment either with electroconvulsive therapy (ECT) or addition of lithium (Li) to the tricyclic. Twenty-one of the 30 patients significantly improved at the end of 3 weeks of treatment. There were no differences in improvement rates between the two groups. However, the patients treated with a Li/tricyclic combination improved more rapidly, showing significant alterations in mental state by day 7. It is suggested that in otherwise physically healthy patients who are tricyclic nonresponders, the addition of Li may be a more rapid treatment than the use of ECT.
Dinan
T G
TG
Department of Psychiatry, Trinity College Medical School, St. James' Hospital, Dublin, Ireland.
Barry
S
S
D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000628:therapy; D003866:Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D004359:Drug Therapy, Combination; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D016651:Lithium Carbonate; D008094:Lithium