Compatibility of ADSOL-stored red cells with intravenous solutions.
Five percent dextrose in water (D5W) and lactated Ringer's (RL) are two intravenous solutions that are incompatible with citrate phosphate dextrose (CPD) anticoagulated RBCs. Hemolysis, agglutination, and clotting can occur when RBCs are mixed with, infused together with, or transfused in the same line following administration of these fluids. Although minimal plasma remains in units of RBCs containing adenine-saline-dextrose solution (ADSOL; Fenwal Laboratories, Deerfield, IL), clots are seen immediately after contact is made with RL. Clumping and hemolysis are seen when ADSOL-stored RBCs or saline-washed RBCs are mixed with D5W. This study reinforces the unsafe practice of mixing RBCs with certain intravenous solutions.
Strautz
R L
RL
Blood Bank and Transfusion Service, Los Angeles County-University of Southern California Medical Center 90033-1084.
Nelson
J M
JM
Meyer
E A
EA
Shulman
I A
IA
D000225:Adenine; D000371:Agglutination; D001793:Blood Preservation; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000502:physiology*; D005947:Glucose / Q000009:adverse effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects*; D007552:Isotonic Solutions / Q000009:adverse effects*; D008353:Mannitol; D000077325:Ringer's Lactate; D012965:Sodium Chloride
C037839:ADSOL; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D008353:Mannitol; D012965:Sodium Chloride; D005947:Glucose; D000225:Adenine