title: A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.
abstract: We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.
authors.affiliation: Department of Biology, Brandeis University, Waltham, MA 02254.
authors.forename: D R
authors.initials: DR
authors.lastname: Rosen
authors.forename: L
authors.initials: L
authors.lastname: Martin-Morris
authors.forename: L Q
authors.initials: LQ
authors.lastname: Luo
authors.forename: K
authors.initials: K
authors.lastname: White
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D011498:Protein Precursors