DNA replication and poly(ADP-ribosyl)ation of chromatin.
The role of poly(ADP-ribosyl)ation in chromatin replication and the activity of poly(ADP-ribose) synthetase in the newly synthesized and old chromatin was studied. It was found that 3-aminobenzamide, which is an inhibitor of poly(ADP-ribose) synthetase, had no effect on the initiation of DNA synthesis and only a moderate effect on DNA chain elongation. However, poly(ADP-ribose) synthetase activity in the newly replicated chromatin was two to three times higher than that of the unreplicated chromatin.
Anachkova
B
B
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
Russev
G
G
Poirier
G G
GG
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004261:DNA Replication; D066298:In Vitro Techniques; D051379:Mice; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism
D002843:Chromatin; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases