title: Tenckhoff catheter replacement or intraperitoneal urokinase: a randomised trial in the management of recurrent continuous ambulatory peritoneal dialysis (CAPD) peritonitis.
abstract: A randomised trial, comparing Tenckhoff catheter replacement as a one-stage procedure and i.p. urokinase, was undertaken in the management of recurrent continuous ambulatory peritoneal dialysis (CAPD) peritonitis. In addition to appropriate i.p. antibiotic treatment, 17 patients received i.p. urokinase (5000 i.u.) on the second and fourth days of antibiotic treatment, and 14 patients underwent CAPD catheter replacement. An additional six patients also underwent catheter replacement following the recurrence of peritonitis after urokinase treatment. The subsequent recurrence rate of peritonitis following CAPD catheter replacement (5%) was significantly less than after urokinase (41%) (p less than 0.001). Fourteen patients remained free of peritonitis for at least three months after catheter replacement, and five patients were peritonitis-free following urokinase for this period.
authors.affiliation: Sheffield Regional Renal Unit, Royal Hallamshire Hospital, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: I
authors.initials: I
authors.lastname: Boletis
authors.forename: B F
authors.initials: BF
authors.lastname: Johnson
authors.forename: A T
authors.initials: AT
authors.lastname: Raftery
authors.forename: G L
authors.initials: GL
authors.lastname: Cohen
authors.forename: P J
authors.initials: PJ
authors.lastname: Moorhead
authors.forename: A M
authors.initials: AM
authors.lastname: el Nahas
authors.forename: C B
authors.initials: CB
authors.lastname: Brown
mesh_terms: D002408:Catheters, Indwelling; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000209:etiology / Q000628:therapy*; D012008:Recurrence; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D005839:Gentamicins; D014640:Vancomycin; D014568:Urokinase-Type Plasminogen Activator