[Thymidine transport and its incorporation into the cellular DNA of Ehrlich ascites cancer and Zajdela's ascitic hepatoma in the presence of thiophosphamide and thiophosphamide-modified DNA].
Antitumour agents, thiotepa and alkylated DNA, inhibit the transport of thymidine in the cells within the first minutes of incubation. Penetration of the exogenous DNA in the Ehrlich ascites tumour cells and stimulation of this process with dimethylsulfoxide are shown. The possible mechanism of the antitumour effect of alkylated DNA is discussed.
Patskovskiĭ
Iu V
IuV
Voloshchuk
T P
TP
D000478:Alkylation; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004247:DNA / Q000187:drug effects* / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis* / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013852:Thiotepa / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium; D014407:Tumor Cells, Cultured; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D014316:Tritium; D004247:DNA; D013852:Thiotepa; D013936:Thymidine; D014529:Uridine
Transport timidina i vkliuchenie ego v DNK kletok astsitnogo raka Erlikha i astsitnoĭ gepatomy Zaĭdela v prisutstvii tiofosfamida i modifitsirovanoĭ im DNK.