[In vitro activity of clofazimine alone and in combination with amikacin, roxithromycin, rifampicin and rifapentine against Mycobacterium avium-intracellulare].
The activity of clofazimine, amikacin, roxithromycin, rifampicin and rifapentine was tested, alone and in association, against Mycobacterium avium intracellulare. Clofazimine, amikacin and rifapentine were shown to be very active. With all established associations, the MIC observed for each drug alone was appreciably reduced.
Casal Román
M
M
Rodríguez López
F
F
Villalba Montoro
R
R
González Requero
A I
AI
D000583:Amikacin / Q000494:pharmacology*; D002991:Clofazimine / Q000494:pharmacology*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015575:Roxithromycin / Q000494:pharmacology*
D015575:Roxithromycin; D000583:Amikacin; D002991:Clofazimine; D012293:Rifampin; C018421:rifapentine
Actividad in vitro de clofacimina aisladamente y en asociación con amikacina, roxitromicina, rifampicina y rifapentina frente a Mycobacterium avium-intracellulare.