title: Cellular communication in leukotriene C4 production between eosinophils and neutrophils.
abstract: Eosinophilic granulocytes as well as neutrophilic granulocytes produced leukotriene C4 (LTC4) on stimulation with 1 microM A23187 (Ca2+ ionophore). In healthy volunteers, the LTC4 production in eosinophils was about 3 times the production in neutrophils. Within 15 min greater than 90% of the LTC4 was released into the supernatant. Stimulation of eosinophils and neutrophils together resulted in a synergistic increase in LTC4 production of 306 +/- 40%. LTC4 synthesis by hypodense eosinophils was also enhanced if stimulated in the presence of neutrophils. These findings suggest a communication between eosinophils and neutrophils, which may play a role in bronchial asthma.
authors.affiliation: Department of Allergology, University Hospital, Groningen, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Kloprogge
authors.forename: A J
authors.initials: AJ
authors.lastname: de Leeuw
authors.forename: J G
authors.initials: JG
authors.lastname: de Monchy
authors.forename: H F
authors.initials: HF
authors.lastname: Kauffman
mesh_terms: D001249:Asthma / Q000276:immunology / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D002450:Cell Communication; D015267:Churg-Strauss Syndrome / Q000276:immunology / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D013189:SRS-A / Q000096:biosynthesis*
chemical_list: D013189:SRS-A; D000001:Calcimycin