[Directed chemotherapy in superficial carcinoma of the bladder conditioned by the knowledge of recurrence factors].
A retrospective study of 56 patients (23 primary and 36 relapsing) with superficial vesical carcinoma and treated with transurethral resection and directed chemoprophylaxis was done. Directed chemoprophylaxis is define as a specific type of adjuvant therapy where the drug is determined by a previous study with multivariant analysis of the relapse risk factors of a group of 385 cases, where the chemotherapeutic agent was also a variable. The drug is specified by the data introduced in a microprocessor program. Such chemoprophylactic approach has achieved a marked reduction in the relapse rate and increased the disease-free interval from 8 to 3 and from 70 to 83.5 respectively, with regard to the free drug choice approach.
Oliver
F
F
Llopis
B
B
Vera
C
C
Domínguez
C
C
Vidal
J
J
Gallego
J
J
Jiménez
J F
JF
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004360:Drug Therapy, Computer-Assisted; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D012307:Risk Factors; D013852:Thiotepa / Q000008:administration & dosage; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000517:prevention & control*
D004317:Doxorubicin; D013852:Thiotepa; D002945:Cisplatin
Quimioterapia dirigida en el carcinoma vesical superficial condicionada por el conocimiento de los factores de recidiva.