title: Arrangements of alpha-globin gene cluster in Taiwan.
abstract: In a gene mapping study on 217 newborn babies in Taiwan with alpha- and zeta-globin probes, we have observed 4 cases (1.84%) of alpha-thalassemia-2 heterozygotes (zeta zeta-alpha/zeta zeta alpha alpha) without increased levels of hemoglobin (Hb) Bart's in the cord blood. Eleven subjects (5.07%) were found to have the South East Asian alpha-thalassemia-1 haplotype (zeta zeta--SEA/zeta zeta alpha alpha) with increased Hb Bart's levels ranging from 2.2 to 9%. One case, with Hb Bart's level of 14% in the cord blood, was found to have the genotype of zeta zeta--SEA/zeta zeta alpha alpha T (0.46%). Four heterozygotes (1.84%) were found with the triple alpha gene anti-rightward arrangement (zeta zeta alpha alpha alpha 3.7/zeta zeta alpha alpha). Twenty-one heterozygotes (9.68%) were found to have the triple zeta-globin gene arrangement (zeta zeta zeta alpha alpha/zeta zeta alpha alpha). A new triple zeta-globin gene variant with a BamHI polymorphism was also observed in this study.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: H W
authors.initials: HW
authors.lastname: Peng
authors.forename: K B
authors.initials: KB
authors.lastname: Choo
authors.forename: C H
authors.initials: CH
authors.lastname: Ho
authors.forename: M S
authors.initials: MS
authors.lastname: Yen
authors.forename: W Y
authors.initials: WY
authors.lastname: Liung
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: Z L
authors.initials: ZL
authors.lastname: Yang
authors.forename: H T
authors.initials: HT
authors.lastname: Ng
authors.forename: K N
authors.initials: KN
authors.lastname: Ching
authors.forename: S H
authors.initials: SH
authors.lastname: Han
mesh_terms: D044466:Asian People; D005914:Globins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D005810:Multigene Family; D009154:Mutation; D013624:Taiwan; D013789:Thalassemia / Q000235:genetics*
chemical_list: D005914:Globins