title: Modulation of the Ca2+- or Pb2+-activated K+-selective channels in human red cells. I. Effects of propranolol.
abstract: To study the effect of propranolol on the Ca2+- or Pb2+-activated K+ permeability in human erythrocytes, K+ effluxes were compared with single-channel currents. The results demonstrate that propranolol has a twofold effect: (1) it renders the channel protein more sensitive to Ca2+ or Pb2+; and (2) it simultaneously inhibits channel activity and slightly reduces single-channel conductance. The number of active channels is not affected.
authors.affiliation: Max-Planck-Institut für Biophysik, Frankfurt, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Schwarz
authors.forename: H
authors.initials: H
authors.lastname: Keim
authors.forename: R
authors.initials: R
authors.lastname: Fehlau
authors.forename: G F
authors.initials: GF
authors.lastname: Fuhrmann
mesh_terms: D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D007854:Lead / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D012964:Sodium / Q000097:blood; D013431:Sulfates / Q000097:blood
chemical_list: D015221:Potassium Channels; D013431:Sulfates; D007854:Lead; D000001:Calcimycin; D012964:Sodium; D011433:Propranolol; D011188:Potassium; D002118:Calcium