title: Pituitary response in the doubled GnRH-TRH test on the 5th day post partum or post abortum after ablactation by oral means of ethinylestradiol sulfonate.
abstract: The function and reactivity of the hypothalamo - anterior pituitary axis had been tested after primary ablactation with ethinylestradiol sulfonate (EES) by means of the doubled GnRH-TRH-test. The reaction of the hypothalamo-pituitary axis is, in early puerperium, drastically reduced by GnRH stimulation. The physiological hyperprolactinemia of puerperium leads to a non-responsiveness by means of exogenous GnRH. Simultaneously there exists a greater sensitivity of the hypothalamo-pituitary system for the negative and a relatively lesser sensitivity for the positive feedback of estrogens in puerperium.
authors.affiliation: Department of Obstetrics and Gynecology, Ernst-Moritz-Arndt-University, Greifswald, DDR.
authors.forename: G
authors.initials: G
authors.lastname: Göretzlehner
authors.forename: W
authors.initials: W
authors.lastname: Wodrig
authors.forename: A
authors.initials: A
authors.lastname: Leminski
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: U
authors.initials: U
authors.lastname: Ulrich
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000503:physiopathology*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D007774:Lactation / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D010906:Pituitary Hormone-Releasing Hormones; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; C025723:ethinyl estradiol sulfonate; D004997:Ethinyl Estradiol; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin