title: Swainsonine: a new antineoplastic immunomodulator.
abstract: Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity imparts this drug a promising future in cancer therapy.
authors.forename: S
authors.initials: S
authors.lastname: Mohla
authors.forename: M J
authors.initials: MJ
authors.lastname: Humphries
authors.forename: S L
authors.initials: SL
authors.lastname: White
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: S A
authors.initials: SA
authors.lastname: Newton
authors.forename: C C
authors.initials: CC
authors.lastname: Sampson
authors.forename: D
authors.initials: D
authors.lastname: Bowen
authors.forename: K
authors.initials: K
authors.lastname: Olden
mesh_terms: D000276:Adjuvants, Immunologic / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D000470:Alkaloids / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D002461:Cell Line, Transformed; D002462:Cell Membrane / Q000187:drug effects; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009844:Oligosaccharides; D017026:Swainsonine
chemical_list: D000276:Adjuvants, Immunologic; D000470:Alkaloids; D000970:Antineoplastic Agents; D009844:Oligosaccharides; D017026:Swainsonine