title: [Islands of Langerhans of cattle--potential donor tissue for clinical islet transplantation?].
abstract: A standard method for bovine islet isolation has been developed. The mean islet yield per gram pancreas obtained from the last twelve consecutive glands was 2,098 +/- 292 representing an insulin recovery of 36.1 +/- 6.5%. The static incubation of freshly isolated bovine islets in the presence of glucose resulted in a less distinct increase of insulin secretion than in the presence of free fatty acids. Nevertheless, xenotransplantation of bovine islets to immunosuppressed C57BL6J mice did reverse streptozotocin-induced diabetes for 2 to 6 days.
authors.affiliation: Medizinischen Klinik III und Poliklinik, Justus-Liebig-Universität Giessen.
authors.forename: B J
authors.initials: BJ
authors.lastname: Hering
authors.forename: D
authors.initials: D
authors.lastname: Romann
authors.forename: A
authors.initials: A
authors.lastname: Clarius
authors.forename: M
authors.initials: M
authors.lastname: Brendel
authors.forename: R G
authors.initials: RG
authors.lastname: Bretzel
authors.forename: K
authors.initials: K
authors.lastname: Federlin
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D014021:Tissue Preservation / Q000379:methods; D014183:Transplantation, Heterologous
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Langerhans' sche Inseln des Rindes--potentielles Spendergewebe für die klinische Inseltransplantation?