gamma-Acetylenic-gamma-aminobutyrate as an enzyme-activated inhibitor of D-amino acid transaminase.
Bacterial D-amino acid transaminase undergoes complete inactivation by gamma-acetylenic GABA. This inactivation is completely prevented by D-alanine and partially prevented by L-alanine. During inactivation the coenzyme portion of the enzyme undergoes significant spectral changes.
Martinez del Pozo
A
A
Rockefeller University, New York, NY 10021.
Ueno
H
H
Merola
M
M
Danzin
C
C
Manning
J M
JM
D000409:Alanine / Q000494:pharmacology; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology*; D001407:Bacillus / Q000201:enzymology; D051263:D-Alanine Transaminase; D013053:Spectrophotometry; D013379:Substrate Specificity; D013997:Time Factors; D000637:Transaminases / Q000037:antagonists & inhibitors*
D000480:Alkynes; D000614:Aminocaproates; C013785:4-amino-5-hexynoic acid; D000637:Transaminases; D051263:D-Alanine Transaminase; D000409:Alanine