title: Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src.
abstract: We isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells. p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein.
authors.affiliation: Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: P A
authors.initials: PA
authors.lastname: Bedard
authors.forename: Y
authors.initials: Y
authors.lastname: Yannoni
authors.forename: D L
authors.initials: DL
authors.lastname: Simmons
authors.forename: R L
authors.initials: RL
authors.lastname: Erikson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005786:Gene Expression Regulation; D007328:Insulin / Q000494:pharmacology*; D007399:Interphase; D054834:Lipocalins; D008969:Molecular Sequence Data; D015688:Oncogene Protein pp60(v-src); D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012191:Retroviridae Proteins / Q000494:pharmacology*
chemical_list: D030161:Avian Proteins; D001798:Blood Proteins; D007328:Insulin; D054834:Lipocalins; D012333:RNA, Messenger; D012191:Retroviridae Proteins; D004815:Epidermal Growth Factor; D004247:DNA; D015688:Oncogene Protein pp60(v-src)