[Initial results following implantation of resorbable micro-patches of polydioxanone in the rat aorta].
Polydioxanon micro-patches were inserted into the infrarenal aorta of 21 rats by means of microsurgical techniques. Histologic characteristics were analysed by light microscopy up to 8 weeks after implantation. The following observations were made: After 4 weeks a regenerated artery with different layers could be seen: Neo-Endothelium-, Neo-Media-, Neo-Adventitia-Patch-layer. Two different proliferation zones were evaluated: the anastomotic adventitial layer, responsible for regenerating the Neo-Adventitia-Patch-layer as a chronic foreign body reaction, the anastomotic intima layer, responsible for regenerating the Neo-Media with differentiation of cells into smooth-muscle-like cells. The lining cells appeared like endothelium-like cells. These study demonstrates the possibility of regenerating arterial tissue over polydioxanon patch in the rat aorta.
Schumann
U
U
Klinik und Poliklinik für Allgemeinchirurgie, Medizinischen Hochschule Hannover.
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D008866:Microsurgery; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000601:surgery*; D016687:Polydioxanone; D011091:Polyesters; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D014945:Wound Healing
D001672:Biocompatible Materials; D011091:Polyesters; D016687:Polydioxanone
Erste Ergebnisse nach Implantation resorbierbarer Mikro-Patchs aus Polydioxanon an der Ratten-Aorta.