title: Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.
abstract: (-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.
authors.affiliation: Department of Surgery, Fukuchiyama National Hospital, Kyoto.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kuwata
authors.forename: J
authors.initials: J
authors.lastname: Okuzumi
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Fujiki
authors.forename: T
authors.initials: T
authors.lastname: Okuda
mesh_terms: D000818:Animals; D002273:Carcinogens; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives*; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure
chemical_list: D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; C013525:ENNG; D002392:Catechin; C045651:epigallocatechin gallate