Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type I.
Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African families with neurofibromatosis type 1 (NF1). The markers--p17H8, pHHH202, and EW204--were linked to NF1 at recombination fractions less than 1%. No evidence of locus heterogeneity was detected. Inspection of recombinant events in families informative for several markers suggests that the NF1 gene is located between the markers EW301 (cen-p11.2) and EW206 (cen-q12) and possibly distal to pHHH202 (q11.2-q12).
Mathew
C G
CG
Section of Human Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom.
Thorpe
K
K
Easton
D F
DF
Chin
K S
KS
Jadayel
D
D
Ponder
M
M
Moore
G
G
Wallis
C E
CE
Slater
C P
CP
De Jong
G
G
D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000235:genetics*; D013019:South Africa; D006113:United Kingdom
D005819:Genetic Markers