Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. I. Taxonomy of the producing strain, fermentation, isolation and biological properties.
A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma.
Nakagawa
M
M
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
Hsu
Y H
YH
Hirota
A
A
Shima
S
S
Nakayama
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002460:Cell Line / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000032:analysis*; D051379:Mice; D008826:Microbial Sensitivity Tests; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D012988:Soil Microbiology
D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D008937:Mitomycins; C058997:myrocin C; D016685:Mitomycin