title: The association between apolipoprotein A-I and prostacyclin binding in human serum.
abstract: The stability of Prostacyclin in human blood is dependent upon binding to circulating proteins. Although this binding has been considered to be primarily due to albumin, a recent report has suggested that apolipoprotein A-I is responsible. We compared prostacyclin binding to the concentration of albumin and apolipoprotein A-I in several groups of sera with known differences in the ability to bind prostacyclin. Our results indicate a strong correlation with albumin concentration but no correlation between binding and the concentration of apolipoprotein A-I. It appears that in the human circulation albumin concentration is the most important determinant of prostacyclin binding.
authors.affiliation: Dept. of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33612.
authors.forename: W F
authors.initials: WF
authors.lastname: O'Brien
authors.forename: C
authors.initials: C
authors.lastname: Torres
authors.forename: R
authors.initials: R
authors.lastname: Benoit
authors.forename: R A
authors.initials: RA
authors.lastname: Knuppel
mesh_terms: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D012709:Serum Albumin; D011464:Epoprostenol