[Efficacy of treatments in experimental toxoplasmosis].
Experimental study of the intraocular penetration of six drugs with therapeutic effect on toxoplasma. A direct and an indirect method are used. The penetration of six drugs administered sub-conjunctival, retrobulbar and intramuscular in one shot is measured in the anterior chamber, the vitreous and the retina-choroid of a healthy rabbit eye. The best results are obtained for: spiramycin, trimethoprim-sulfamethoxazole and clindamycin. The therapeutic efficiency of four drugs on infected rabbit eyes with toxoplasma are studied using an indirect method: pyrimethamine and especially doxycycline have a positive effect.
Tassignon
M J
MJ
Brihaye
M
M
De Meuter
F
F
Vercruysse
A
A
Van Hoof
F
F
De Wilde
F
F
D000818:Animals; D001813:Blood-Retinal Barrier / Q000187:drug effects*; D002981:Clindamycin / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D008297:Male; D011739:Pyrimethamine / Q000008:administration & dosage; D011817:Rabbits; D015572:Spiramycin / Q000008:administration & dosage; D014124:Toxoplasmosis, Animal / Q000188:drug therapy* / Q000378:metabolism; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
D002981:Clindamycin; D015572:Spiramycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D004318:Doxycycline; D011739:Pyrimethamine
Etude de l'efficacité des traitements dans la toxoplasmose expérimentale.