Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake.
Epidemiological studies were performed in a Japanese fishing village when catches of fish were highest and in a Japanese farming village with usual fish consumption. Intake of eicosapentaenoic, docosahexaenoic and also arachidonic acid were significantly higher in the fishing village during the 3 days of the study than in the farming village. The correlation between eicosapentaenoic acid intake on the day when urine was collected and excretion of delta 17-2,3-dinor-6-keto-prostaglandin F1 alpha, the main urinary metabolite of prostaglandin I3, was highly significant, whereas there was no correlation between arachidonic or linoleic acid intake and excretion of 2,3-dinor-6-keto-prostaglandin F1 alpha, the main urinary metabolite of prostaglandin I2. We suggest that the arachidonic acid pool for prostaglandin I2 production is not quickly influenced by dietary linoleic or arachidonic acid because of a large pool size of arachidonic acid and a slow conversion of linoleic acid to arachidonic acid, while prostaglandin I3 formation is directly related to the intake of eicosapentaenoic acid.
Hamazaki
T
T
First Dept. of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Fischer
S
S
Urakaze
M
M
Sawazaki
S
S
Yano
S
S
Kuwamori
T
T
D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives* / Q000652:urine; D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D004032:Diet; D004041:Dietary Fats; D002149:Energy Intake; D005260:Female; D005395:Fish Oils; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007564:Japan; D019787:Linoleic Acid; D008041:Linoleic Acids; D008297:Male; D008875:Middle Aged
D001095:Arachidonic Acids; D004041:Dietary Fats; D005395:Fish Oils; D008041:Linoleic Acids; D016718:Arachidonic Acid; D015121:6-Ketoprostaglandin F1 alpha; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; D019787:Linoleic Acid