Effects of iron-EDTA on uroporphyrinogen oxidation by liver microsomes.
Uroporphyrinogen oxidation by hepatic microsomes from chick embryos or mice pretreated with methylcholanthrene was increased by addition of iron-EDTA. This increase was partially prevented by catalase, mannitol, ketoconazole and piperonyl butoxide, whereas only ketoconazole and piperonyl butoxide inhibited the oxidation in the presence and absence of iron-EDTA. These data suggest that the oxidations of uroporphyrinogen in the presence and absence of added iron occur by different mechanisms.
Jacobs
J M
JM
Veterans Administration, White River Junction, VT 05001.
Sinclair
P R
PR
Lambrecht
R W
RW
Sinclair
J F
JF
D000818:Animals; D002374:Catalase / Q000378:metabolism; D002642:Chick Embryo; D004492:Edetic Acid / Q000494:pharmacology*; D005290:Ferric Compounds / Q000494:pharmacology*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D010882:Piperonyl Butoxide / Q000494:pharmacology; D011078:Polychlorinated Biphenyls / Q000494:pharmacology; D011165:Porphyrinogens / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014577:Uroporphyrinogens / Q000378:metabolism*
D005290:Ferric Compounds; D007502:Iron Chelating Agents; D011165:Porphyrinogens; D014577:Uroporphyrinogens; D004492:Edetic Acid; D011078:Polychlorinated Biphenyls; D002374:Catalase; D013482:Superoxide Dismutase; C019179:Fe(III)-EDTA; D010882:Piperonyl Butoxide; D007654:Ketoconazole; C028451:3,4,3',4'-tetrachlorobiphenyl