Short-term effects of fat emulsion on serum lipids in postoperative patients.
The effect of short-term infusion of intravenous fat on serum lipids was assessed in 23 patients who had elective cancer operations and were given 20% Intralipid for 5 days postoperatively as part of a standard total parenteral nutrition regimen. Serum lipids were measured prior to, during and after the 5-day infusion period. The percentage of cholesterol as high-density lipoproteins (HDL) fell from a mean preinfusion value of 34.7 +/- 2.8 to 27.9 +/- 2.5 (p less than 0.05), while the percentage of cholesterol as low-density lipoproteins (LDL) increased from 40.7 +/- 2.2 to 46.8 +/- 3.4 (p less than 0.05). Serum triglycerides fell significantly (p less than 0.01) from 106.2 +/- 13.7 mg/dl to 64.6 +/- 8.8 mg/dl at 3 days, being 85.3 +/- 3.7 mg/dl at 5 days. No significant change in percent cholesterol as very low-density lipoproteins (VLDL), or levels of serum total cholesterol or phospholipids occurred. Lipoprotein X was detectable in six patients after 5 days. To study triglyceride clearance 1.7 g/kg of fat emulsion was infused over 8 hr and serial blood samples obtained. Within 3 hr of stopping the fat infusion, triglyceride levels had fallen to preinfusion values.
Meguid
M M
MM
Department of Surgery, SUNY Health Sciences Center 13210.
Kurzer
M
M
Hayashi
R J
RJ
Akahoshi
M P
MP
D002784:Cholesterol / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008073:Lipoprotein-X / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008073:Lipoprotein-X; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol