[Effect of histamine on the capillary permeability of the nasal mucosa in normal rats].
The effect of histamine on the capillary permeability of the nasal mucosa was studied quantitatively in normal rats using the Evans blue technique. The content of Evans blue in terms of ng per mg of nasal mucosa was significantly (P less than 0.001) higher in histamine group than that in control group, and reached peak value five minutes after injection of histamine at the concentration of 10(-8) mol/L. It is thought that this preliminary result might be useful in selecting optimal concentration of the challenge agent and the optimal time to evaluate the reaction.
Yang
P
P
First Clinical College, Hunan Medical University, Changsha.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000098:blood supply*; D051381:Rats; D011919:Rats, Inbred Strains
D006632:Histamine