title: Vaginal hemorrhage associated with degenerating submucous leiomyomata during leuprolide acetate treatment.
abstract: Three cases of heavy vaginal bleeding during leuprolide acetate therapy for leiomyomata are reported. In all cases, acute anemia developed, necessitating blood transfusions and emergency myomectomies. Pathologic diagnoses demonstrated hyaline degeneration of submucous fibroids in each instance.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: A J
authors.initials: AJ
authors.lastname: Friedman
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000473:pathology; D016729:Leuprolide; D008595:Menorrhagia / Q000139:chemically induced*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide