Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen.
The intracellular effects of different diphosphonates on splenic macrophages were compared after intravenous injection of liposomes with encapsulated dichloromethylene diphosphonate (C12MDP), 3-amino-1-hydroxypropane-1,1-diphosphonate (APD), or 1 hydroxyethane-1,1-diphosphonate (EHDP) in similar concentrations. Intracellular C12MDP was by far the most toxic compound for macrophages in the spleen. APD encapsulated in liposomes in the highest possible concentration eliminated marginal zone macrophages only and EHDP did not affect any of the macrophage subpopulations in the spleen.
van Rooijen
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Department of Histology, Medical Faculty, Free University, Amsterdam, The Netherlands.
Kors
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D000818:Animals; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D004337:Drug Carriers; D012968:Etidronic Acid / Q000494:pharmacology; D005260:Female; D008081:Liposomes; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D000077268:Pamidronate; D010586:Phagocytes / Q000187:drug effects*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects
D004164:Diphosphonates; D004337:Drug Carriers; D008081:Liposomes; D012968:Etidronic Acid; D000077268:Pamidronate