Vaccinia-interleukin 2 recombinant virus or exogenous interleukin 2 does not alter the magnitude or immune response gene defects of the cytotoxic T-cell response to vaccinia virus in vivo.
We investigated the role of interleukin 2 (IL-2), a T cell-derived lymphokine, in the generation of in vivo cytotoxic T-cell responses to vaccinia virus. We made use of a recombinant vaccinia virus encoding and expressing the murine IL-2 gene and recombinant IL-2 to test the role of IL-2 in the expression of major histocompatibility complex (MHC) class I determined immune response (Ir) gene defects in the response to vaccinia virus. IL-2 expressed either by the vaccinia virus vector or exogenous IL-2 does not alter Ir gene defects nor does IL-2 under such conditions elevate the cytotoxic T-cell response in general.
Müllbacher
A
A
Department of Microbiology, John Curtin School of Medical Research, Canberra, Australia.
Ramshaw
I A
IA
Coupar
B E
BE
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology; D007376:Interleukin-2 / Q000008:administration & dosage*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins / Q000008:administration & dosage; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014612:Vaccines / Q000008:administration & dosage*; D014614:Vaccines, Synthetic / Q000008:administration & dosage*; D014616:Vaccinia virus / Q000276:immunology*
D006183:H-2 Antigens; D007376:Interleukin-2; D011994:Recombinant Proteins; D014612:Vaccines; D014614:Vaccines, Synthetic