The effect of aldose reductase inhibitor, statil, on hyperpermeability of iridial vessels in experimental galactosemic rats.
Thirty young male Sprague-Dawley rats were divided into three groups: the control group, given a normal diet; the galactose group, given a 25% galactose diet; and the aldose reductase-galactose group, given a 25% galactose diet containing 0.046% Statil, an aldose reductase inhibitor. The results suggested that Statil could prevent hyperpermeability of iridial vessels in galactose-fed rats.
Terubayashi
H
H
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Akagi
Y
Y
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D005451:Fluorescein Angiography; D005693:Galactosemias / Q000378:metabolism* / Q000503:physiopathology; D007498:Iris / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D010793:Phthalazines / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D010793:Phthalazines; D011724:Pyridazines; C042829:ponalrestat; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase