title: Ontogeny of the third component of complement in neonatal swine.
abstract: Ontogeny of the third component of complement (C3) was monitored in 10 neonatal swine, using a radial immunodiffusion technique. Significant differences in mean serum C3 concentrations, expressed as percentage of C3 concentration in a pooled standard drawn from 15 adult swine, were not observed between serum samples collected before pigs suckled and at 2 days of age (P = 0.2583). Serum C3 concentrations increased significantly between 2 and 7 days of age (P less than 0.0001) and 7 and 14 days of age (P less than 0.0001). Concentrations comparable with those in adults were observed at 14 days of age and significant changes were not observed thereafter. Acquisition of adult concentrations of C3 appeared to be a function of endogenous production by the neonate, rather than by passive colostral transfer.
authors.affiliation: Department of Clinical Pathology, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
authors.forename: J S
authors.initials: JS
authors.lastname: Cullor
authors.forename: V L
authors.initials: VL
authors.lastname: Douglas
authors.forename: K M
authors.initials: KM
authors.lastname: Parker
authors.forename: W L
authors.initials: WL
authors.lastname: Smith
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D003126:Colostrum / Q000276:immunology; D003176:Complement C3 / Q000032:analysis*; D005260:Female; D005779:Immunodiffusion / Q000662:veterinary; D007074:Immunoglobulin G / Q000032:analysis*; D007774:Lactation; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D013552:Swine / Q000276:immunology*; D013997:Time Factors
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G