Determinants of homologous blood usage utilizing autologous platelet-rich plasma in cardiac operations.
The present study evaluated (1) the influence of the collection of autologous platelet-rich plasma intraoperatively in addition to intraoperative autotransfusion on homologous blood usage and bleeding in cardiac operations; (2) the influence of age, sex, body surface area, type of operation, and reoperations on homologous blood usage and bleeding in cardiac operations utilizing intraoperative autotransfusion and autologous platelet-rich plasma collected intraoperatively; and (3) the influence of the preoperative administration of aspirin, Persantine (dipyridamole), heparin sodium, thrombolytic agents, Coumadin (crystalline warfarin sodium), and nonsteroid, antiinflammatory drugs on homologous blood usage and bleeding in cardiac operations utilizing intraoperative autotransfusion and autologous platelet-rich plasma collected intraoperatively. The results demonstrated a decrease in homologous blood use and bleeding when autologous platelet-rich plasma is collected in addition to the use of intraoperative autotransfusion. All of the patient and procedural variables influenced homologous blood usage and bleeding to some extent. Only the thrombolytic agents affected blood usage by increasing homologous plasma usage. All other drugs evaluated did not influence blood utilization or the amount of bleeding intraoperatively or postoperatively.
Giordano
G F
GF
Southern Arizona Regional Red Cross Blood Program, Tucson 85719.
Giordano
G F
GF
Rivers
S L
SL
Chung
G K
GK
Mammana
R B
RB
Marco
J D
JD
Raczkowski
A R
AR
Sabbagh
A
A
Sanderson
R G
RG
Strug
B S
BS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D010949:Plasma; D013300:Streptokinase / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D004176:Dipyridamole; D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D001241:Aspirin