Histiocytic hemophagocytosis in the bone marrow in children with sepsis and disseminated intravascular coagulation.
Two children with systemic E. coli and candidial infections developed disseminated intravascular coagulation (DIC). Bone marrow examination in both cases showed histiocytic hemophagocytosis, consistent with the diagnosis of the hemophagocytic syndrome. Histiocytic hemophagocytosis in the bone marrow, one of the markers of the activated mononuclear phagocyte system, might be common in patients with severe sepsis and DIC, especially in immunodeficiency.
Hara
T
T
Honjo
S
S
Miyazaki
C
C
Mizuno
Y
Y
Suda
M
M
Yamasaki
T
T
Ueda
K
K
D000293:Adolescent; D001773:Blood Cells; D001855:Bone Marrow Diseases / Q000209:etiology*; D002177:Candidiasis / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D004927:Escherichia coli Infections / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D010587:Phagocytosis