Effects of salicylate and zinc deficiency on the serum concentrations of magnesium, calcium, and parathyroid hormone.
Oral application of 700 mg/kg salicylic acid to pregnant and non-pregnant female rats caused an increase of serum Mg2+ and a decrease of serum Ca2+ concentration. The salicylate effect was drastically enhanced by Zn deficiency. The increase in serum Mg2+ is probably caused by the nephrotoxicity of salicylate. The decrease of serum Ca2+ concentration is combined with an increase of parathyroid hormone concentration in serum. Probably, salicylate and Zn deficiency inhibit Ca2+ mobilization by parathyroid hormone in bone.
Günther
T
T
Institute of Molecular Biology and Biochemistry, Free University of Berlin, FRG.
Höllriegl
V
V
Vormann
J
J
D000818:Animals; D002118:Calcium / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D007674:Kidney Diseases / Q000139:chemically induced; D008274:Magnesium / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000494:pharmacology* / Q000633:toxicity; D020156:Salicylic Acid; D015032:Zinc / Q000172:deficiency*
D010281:Parathyroid Hormone; D012459:Salicylates; D008274:Magnesium; D015032:Zinc; D020156:Salicylic Acid; D002118:Calcium