Decontaminating efficacy of ciprofloxacin in an animal model.
A study was performed to assess the suppressive effect of ciprofloxacin on the aerobic gram-negative flora of the gastrointestinal tract in mice in relation to its effect on colonization resistance. Ciprofloxacin exhibited a potent decontaminating effect, with the maximum effect being reached at a dose of 8 mg/kg/day. At this dose aerobic gram-negative rods were eliminated from the gastrointestinal tract within 24h without any adverse influence on the parameters of colonization resistance measured.
van Ogtrop
M L
ML
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Mattie
H
H
Guiot
H F
HF
van Furth
R
R
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D002432:Cecum / Q000382:microbiology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D004064:Digestive System / Q000382:microbiology*; D004195:Disease Models, Animal; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D008297:Male; D051379:Mice
D002939:Ciprofloxacin