Combined host and specific anti-Pseudomonas-directed therapy for Pseudomonas aeruginosa infections in burned mice: experimental results and theoretic considerations.
Four strains of Pseudomonas aeruginosa showed significant variation in the elaboration of the virulence-associated exoproducts, exotoxin A and proteases. These variations appeared to affect the mortality observed when these strains were used to infect burned mice. Further, these variations seemed to influence the efficacy of individual after sepsis treatments designed to (1) reduce total microbial load in the host (HIg treatment), (2) reduce total circulating protease load in the host (alpha 1-PI treatment), or (3) neutralize the specific effects of exotoxin A (antitoxin treatment). Combined treatment, using all of these approaches, was significantly better than individual treatment.
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University of Cincinnati College of Medicine, Shriners Burns Institute, Ohio 45219.
Neely
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D036002:ADP Ribose Transferases; D000818:Animals; D001427:Bacterial Toxins; D001798:Blood Proteins / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D005098:Exotoxins / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D010447:Peptide Hydrolases / Q000096:biosynthesis; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000378:metabolism / Q000472:pathogenicity*; D013045:Species Specificity; D014774:Virulence; D037521:Virulence Factors; D000515:alpha 1-Antitrypsin; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D001798:Blood Proteins; D005098:Exotoxins; D010447:Peptide Hydrolases; D011480:Protease Inhibitors; D037521:Virulence Factors; D000515:alpha 1-Antitrypsin; D000097668:Pseudomonas aeruginosa Exotoxin A