The genes for apolipoprotein all (APOA2) and the Duffy blood group (FY) are linked on chromosome 1 in man.
We have cloned a cDNA probe for human apolipoprotein AII and used it to analyze linkage relationships on chromosome 1. We found no recombinations between APOA2 and the gene coding for the Duffy blood group antigens (FY) in the 19 meioses examined. Our maximal lod score is 4.2 at zero recombination rate. K. Berg (1987, Cytogenet. Cell Genet. 46:579) found a maximal score of 2.5 at recombination fraction 0.14 in 54 meioses. When results from both studies are combined, the most likely distance between FY and APOA2 is about 10% recombination with a combined lod score of 5.6 for both sexes.
Rogne
S
S
Institute for Animal Science, Agricultural University, As-NLH, Norway.
Myklebost
O
O
Høyheim
B
B
Olaisen
B
B
Gedde-Dahl
T
T
D000595:Amino Acid Sequence; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A / Q000235:genetics*; D001483:Base Sequence; D001789:Blood Group Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D004247:DNA; D004375:Duffy Blood-Group System / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008969:Molecular Sequence Data
D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D004247:DNA