Factors modifying valproate plasma level/dose ratio: age, sex, dose and plasma level.
Valproate plasma level/dose (L/D) ratios obtained from 155 outpatients under long-term monotherapeutic regimen have been studied. Analytical data were obtained by enzymatic immunoassay (EMIT) from paired samples taken before the morning drug dosage. L/D ratios were increased with age and plasma level and decreased with dose. There were no sex differences in L/D in the different age, dose and concentration groups. L/D ratios were higher than those found by other researchers in our country.
Sánchez
A
A
Clinical Pharmacology Department, University Hospital, School of Medicine, Seville, Spain.
Durán
J A
JA
Abadín
J A
JA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000097:blood*
D014635:Valproic Acid