title: Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency.
abstract: In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.
authors.affiliation: Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, FRG.
authors.forename: T
authors.initials: T
authors.lastname: Günther
authors.forename: E
authors.initials: E
authors.lastname: Rebentisch
authors.forename: J
authors.initials: J
authors.lastname: Vormann
authors.forename: M
authors.initials: M
authors.lastname: König
authors.forename: H
authors.initials: H
authors.lastname: Ising
mesh_terms: D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006311:Hearing Disorders / Q000139:chemically induced*; D008275:Magnesium Deficiency / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000633:toxicity*; D020156:Salicylic Acid; D015032:Zinc / Q000172:deficiency*
chemical_list: D005839:Gentamicins; D012459:Salicylates; D015032:Zinc; D020156:Salicylic Acid