The effects of single L-amino acid substitutions on the lethal potencies of the microcystins.
Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity.
Stoner
R D
RD
Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973.
Adams
W H
WH
Slatkin
D N
DN
Siegelman
H W
HW
D000375:Aging; D000596:Amino Acids; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001427:Bacterial Toxins; D000458:Cyanobacteria / Q000032:analysis*; D000087522:Cyanobacteria Toxins; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008387:Marine Toxins / Q000032:analysis / Q000633:toxicity*; D051379:Mice; D052998:Microcystins
D000596:Amino Acids; D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D008387:Marine Toxins; D052998:Microcystins