title: IgG subclass responses to a transmembrane protein (gp41) peptide in HIV infection.
abstract: The IgG subclass distribution to the E34/E32 peptides, derived from the HIV-1 glycoprotein 41 transmembrane protein, was analyzed in ELISA. Sera from individuals at different stages of the disease were assayed. A restricted subclass response of mainly IgG1 and IgG2 was found. The subclass response was of a different type than the one observed to HIV whole Ag and to a synthetic peptide from the C'-terminal part of the HIV-1 p24 core protein. An increased subclass restriction was observed in progressed stages of the disease.
authors.affiliation: Department of Virology, Karolinska Institute, Stockholm, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Chiodi
authors.forename: T
authors.initials: T
authors.lastname: Mathiesen
authors.forename: J
authors.initials: J
authors.lastname: Albert
authors.forename: E
authors.initials: E
authors.lastname: Parks
authors.forename: E
authors.initials: E
authors.lastname: Norrby
authors.forename: B
authors.initials: B
authors.lastname: Wahren
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000378:metabolism; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D015483:HIV Antibodies / Q000096:biosynthesis* / Q000145:classification; D015488:HIV Antigens / Q000276:immunology*; D016655:HIV Core Protein p24; D015700:HIV Envelope Protein gp41; D015497:HIV-1 / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification* / Q000378:metabolism; D008565:Membrane Proteins / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D012191:Retroviridae Proteins / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000596:Amino Acids; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D015700:HIV Envelope Protein gp41; D007074:Immunoglobulin G; D008565:Membrane Proteins; D010455:Peptides; D012191:Retroviridae Proteins; D014759:Viral Envelope Proteins