Extracorporeal complexation haemodialysis for the treatment of cadmium poisoning. II. In vivo mobilization and removal.
The purpose of this study was to apply our earlier in vitro findings for extracorporeal complexation combined with haemodialysis to in vivo conditions, for the enhancement of cadmium (Cd) removal from dogs. The results showed that ethylenediaminetetraacetic acid (EDTA), glutathione (GSH) and combination of the two agents (EDTA + GSH) facilitated efficient elimination of cadmium. GSH, EDTA and EDTA + GSH treatments brought about the clearance of 2.2, 14.7 and 18.2 micrograms Cd/kg body weight/hr haemodialysis, respectively. Treatment with EDTA + GSH brought about the most rapid extravascular redistribution of the metal.
Sheabar
F Z
FZ
Department of Food Engineering and Biotechnology, Technion--Israel Institute of Technology, Haifa, Israel.
Yannai
S
S
Taitelman
U
U
D000818:Animals; D002104:Cadmium / Q000097:blood; D002105:Cadmium Poisoning / Q000188:drug therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D004285:Dogs; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D005978:Glutathione / Q000627:therapeutic use; D008297:Male; D006435:Renal Dialysis
D002614:Chelating Agents; D002104:Cadmium; D004492:Edetic Acid; D005978:Glutathione