Inhibitory effect of a synthetic polypeptide, poly(Tyr-Ile-Gly-Ser-Arg), on the metastatic formation of malignant tumour cells.
A new type of polypeptide containing the repeating sequence of cell attachment site in laminin, poly(Tyr-Ile-Gly-Ser-Arg), was synthesized by the polymerization procedure with diphenylphosphoryl azide (DPPA). We found that this polypeptide inhibited the metastatic formation in the lung of malignant tumour cells far more effectively than pentapeptide.
Murata
J
J
Institute of Immunological Science, Sapporo, Japan.
Saiki
I
I
Azuma
I
I
Nishi
N
N
D000595:Amino Acid Sequence; D000818:Animals; D036341:Intercellular Signaling Peptides and Proteins; D007797:Laminin / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology*; D010455:Peptides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D036341:Intercellular Signaling Peptides and Proteins; D007797:Laminin; D010455:Peptides; C068537:poly(tyrosyl-isoleucyl-glycyl-seryl-arginine)