Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase.
To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the potency of inhibitory activity. The activities of extracts of Scutellaria baicalensis, Andrographis paniculata and Gutierrezia microcephala are also described.
Iinuma
M
M
Tanaka
T
T
Mizuno
M
M
Katsuzaki
T
T
Ogawa
H
H
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D005419:Flavonoids / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D005419:Flavonoids; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase