A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment.
Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3-4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found.
Fornstedt
B
B
Department of Pharmacology, University of Göteborg, Sweden.
Carlsson
A
A
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003548:Cysteinyldopa / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D012110:Reserpine / Q000494:pharmacology*
D015102:3,4-Dihydroxyphenylacetic Acid; D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine; D012110:Reserpine; D004298:Dopamine