Amyloid beta protein precursor is a mitogen.
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
Schubert
D
D
Salk Institute for Biological Studies, San Diego, California 92138.
Cole
G
G
Saitoh
T
T
Oltersdorf
T
T
D000544:Alzheimer Disease / Q000473:pathology; D000682:Amyloid / Q000235:genetics / Q000502:physiology*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D003470:Culture Media; D005347:Fibroblasts / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007668:Kidney; D051379:Mice; D011480:Protease Inhibitors / Q000502:physiology; D011498:Protein Precursors / Q000235:genetics / Q000502:physiology*; D014162:Transfection
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D003470:Culture Media; D006133:Growth Substances; D011480:Protease Inhibitors; D011498:Protein Precursors