The role of sympathetic nervous system in the action of dopamine and dobutamine on the function of circulatory system.
To assess the role of peripheral structures of the sympathetic nervous system in the effects of dopamine and dobutamine on some functions of the cardiovascular system, experiments were carried out on anesthetized rabbits in which the blood flow in calf muscles was measured, during rest and during evoked twitches, using the method of 133Xe clearance. The arterial blood pressure and ECG were simultaneously recorded. A complete reversal of the action of dopamine on the arterial blood pressure and heart rate, after sympathetic nerve endings blockade, indicates an important role for the undisturbed neurotransmission in revealing hypotensive properties of this amine. In the action of dobutamine on blood pressure, heart rate and muscle blood flow, the blockade of peripheral structures of the sympathetic nervous system is of minor importance.
Krawczak
J
J
Department of Pharmacology, Medical Academy, Poznań, Poland.
Beutler
A
A
Kozłowska
T
T
Olejnik
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000098:blood supply; D009411:Nerve Endings / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*
D004280:Dobutamine; D004298:Dopamine; D010646:Phentolamine