Phosphatidylcholine does not affect peritoneal transport of intact rabbits.
Ultrafiltration and solute transport during 60-min peritoneal dialyses of normal rabbits with intraperitoneal administration of phosphatidylcholine were compared to control values. The ultrafiltration rate of 0.27 mL/Kg/min did not increase when phosphatidylcholine was added. This agent had no effect on the ultrafiltration coefficient, sodium mass transport or solute clearances. Previously reported beneficial results with this agent could be due to repletion of a deficiency or an effect of the organic solvent. More studies of safety and efficacy of phosphatidylcholine are warranted before widespread clinical use.
Di Paolo
B
B
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799.
Chakrabarti
E
E
Maher
J F
JF
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005260:Female; D007263:Infusions, Parenteral; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000502:physiology*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D014462:Ultrafiltration
D010713:Phosphatidylcholines