title: Second-order repeats in Xenopus laevis finger proteins.
abstract: The primary structure of 342 finger repeats encoded in 42 different cDNA clones isolated from Xenopus laevis oocyte and gastrula cDNA libraries has been determined. Comparative sequence analysis of the predicted protein sequences results in a consensus repeat sequence that has an extended conserved segment of 16 amino acid residues, including the evolutionary conserved H/C link element, connected to a highly variable segment that is located in the finger loop region. Groups of tandem finger repeats are found to be organized in distinct higher-order structural units, with a pair of mutually distinct fingers being the most frequently observed second-order repeat unit. Structural features observed are discussed in respect to existing models for Zn finger structure and function.
authors.affiliation: Max-Planck-Institut für Molekulare Genetik, Otto-Warburg-Laboratorium Ihnestrasse 73, Berlin, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Nietfeld
authors.forename: T
authors.initials: T
authors.lastname: el-Baradi
authors.forename: H
authors.initials: H
authors.lastname: Mentzel
authors.forename: T
authors.initials: T
authors.lastname: Pieler
authors.forename: M
authors.initials: M
authors.lastname: Köster
authors.forename: A
authors.initials: A
authors.lastname: Pöting
authors.forename: W
authors.initials: W
authors.lastname: Knöchel
mesh_terms: D000596:Amino Acids; D000818:Animals; D001483:Base Sequence; D004270:DNA, Circular; D004268:DNA-Binding Proteins; D008667:Metalloproteins; D008957:Models, Genetic; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D014982:Xenopus laevis / Q000235:genetics*; D015032:Zinc
chemical_list: D000596:Amino Acids; D004270:DNA, Circular; D004268:DNA-Binding Proteins; D008667:Metalloproteins; D015032:Zinc