title: Rate of action of schistosomicides in mice infected with Schistosoma mansoni.
abstract: Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.
authors.affiliation: Centro de Pesquisas René Rachou/FIOCRUZ, Brasil.
authors.forename: N
authors.initials: N
authors.lastname: Katz
authors.forename: E P
authors.initials: EP
authors.lastname: Dias
authors.forename: C P
authors.initials: CP
authors.lastname: de Souza
authors.forename: J I
authors.initials: JI
authors.lastname: Bruce
authors.forename: G C
authors.initials: GC
authors.lastname: Coles
mesh_terms: D000818:Animals; D051379:Mice; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects*; D012556:Schistosomicides / Q000493:pharmacokinetics*
chemical_list: D012556:Schistosomicides