Insulin, growth hormone, glucose, and fatty acids in gilts selected for rapid vs. slow growth rate.
Twelve-hour plasma profiles of growth hormone (GH), insulin, glucose, and nonesterified free fatty acids (NEFA), as well as GH, insulin, and glucose responses to saline, glucose, arginine, and human pancreatic growth hormone-releasing factor (GRF) infusion were examined in 15 crossbred gilts, selected for rapid vs. slow growth. For experiment 1 GH and insulin patterns differed (P less than 0.05) between the rapid growth line (RGL) and slow growth line (SGL). Mean GH concentrations in SGL and RGL gilts were 4.1 and 3.2 ng/ml, respectively (P less than 0.05). Plasma GH profile area was greater (P less than 0.08) for SGL than RGL gilts. Glucose level, glucose area, and insulin level were higher (P less than 0.05) for RGL than SGL gilts. Plasma NEFA levels and area were greater (P less than 0.05) for SGL gilts. In experiment 2 responses of GH, insulin, and glucose to saline, glucose, arginine, and GRF infusions varied (P less than 0.05) between and within lines relative to control values. These results indicate that selection for growth rate results in concomitant changes in endocrine and metabolic status.
Norton
S A
SA
Department of Animal Science, Oklahoma State University, Stillwater 74078.
Zavy
M T
MT
Maxwell
C V
CV
Buchanan
D S
DS
Breazile
J E
JE
D000375:Aging; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D007328:Insulin / Q000097:blood*; D013045:Species Specificity; D013552:Swine / Q000254:growth & development*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D001120:Arginine; D005947:Glucose