title: Calculation of rates of immunologically determined accepted mutations (IDAM) for 6 primate plasma proteins.
abstract: The possibility to estimate the rates of immunologically determined accepted mutations (IDAMs) in analogy to accepted point mutation (PAM) rates at the amino acid level is demonstrated for 6 primate plasma proteins. The comparative determinant analysis is described and compared with older techniques. The technique and its limitations are discussed as are the conditions a polypeptide region must fulfill to become an antigenic determinant binding to a specific antibody. IDAM rates obtained this way range between 0.70 and 8.35 per 100 residues and 100 million years. Comparisons between IDAM and PAM rates are given.
authors.affiliation: Faculty of Theoretical Medicine, University of Heidelberg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Bauer
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016056:Immunodominant Epitopes / Q000235:genetics; D009154:Mutation; D010802:Phylogeny; D011323:Primates / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity
chemical_list: D001798:Blood Proteins; D016056:Immunodominant Epitopes