title: Heinz bodies do not modify the membrane characteristics of common marmoset (Callithrix jacchus) erythrocytes.
abstract: The possibility was examined that the membrane function of erythrocytes obtained from healthy common marmosets (Callithrix jacchus) was modified by the presence in the cells of Heinz bodies. No significant differences were found in erythrocyte endogenous free malonyl dialdehyde (MDA) or reduced glutathione (GSH) between normal human erythrocytes and marmoset erythrocytes containing Heinz bodies. Membrane fluorescent chromolipids, surface charge and thiol levels were similar in both species but average membrane bulk lipid fluidity was slightly elevated in the marmosets. It was concluded that, in contrast to the situation in human erythrocytes, the presence of Heinz bodies in red cells of marmosets does not adversely affect the properties of the membrane.
authors.affiliation: Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, London, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Omorphos
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
authors.forename: C
authors.initials: C
authors.lastname: Hawkey
mesh_terms: D000818:Animals; D002144:Callithrix / Q000097:blood*; D002143:Callitrichinae / Q000097:blood*; D004910:Erythrocyte Membrane / Q000473:pathology*; D005260:Female; D005978:Glutathione / Q000097:blood; D006366:Heinz Bodies / Q000473:pathology*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction
chemical_list: D008315:Malondialdehyde; D005978:Glutathione