From cell code to gene code: cytokines and transcription factors.
Cytokines are polypeptides released by host cells during immune responses against foreign agents. Cytokines serve as intercellular messengers and induce transcription of a variety of genes in many different target cells. Transcriptional induction is mediated by transcription factors, which influence gene expression by interacting with specific elements in their regulatory regions. Here we discuss transcription factors involved in the regulation of cytokines and their receptors (interleukin-2, interleukin-2 receptor alpha chain, and interferon-beta), as well as transcription factors that are activated by cytokines (interleukin-1, tumor necrosis factor, interferons, and transforming growth factor beta).
Muegge
K
K
Biological Carcinogenesis Development Program, Program Resources, Inc., Frederick, MD.
Durum
S K
SK
D000818:Animals; D016207:Cytokines / Q000235:genetics*; D005809:Genes, Regulator; D006801:Humans; D007378:Interleukins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D016207:Cytokines; D007378:Interleukins; D014157:Transcription Factors