Granulocyte/macrophage colony stimulating factor. A potent activation signal for mature macrophages and monocytes.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a well-characterized hematopoietic growth factor. Recently, using purified recombinant-derived material, we have found that GM-CSF is also a potent activator of mature functional macrophages. Thus, we have found that exogenous GM-CSF augments the primary plaque-forming response to sheep red blood cells and that this effect is due to upregulation of Ia antigen expression and interleukin 1 production by the macrophages. We also show that GM-CSF inhibits the replication of Trypanosoma cruzi in cultured peritoneal macrophages and causes an accelerated clearance of Salmonella typhimurium from the peritoneal cavity of mice. These data indicate that GM-CSF is a multifunctional molecule stimulating both hematopoiesis and mature macrophage function.
Morrissey
P J
PJ
Immunex Corp., Seattle, Wash.
Grabstein
K H
KH
Reed
S G
SG
Conlon
P J
PJ
D000818:Animals; D000917:Antibody Formation; D001770:Blood Bactericidal Activity; D016026:Bone Marrow Transplantation; D014355:Chagas Disease / Q000276:immunology; D003115:Colony-Stimulating Factors / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D066298:In Vitro Techniques; D008262:Macrophage Activation; D008264:Macrophages / Q000469:parasitology / Q000502:physiology*; D051379:Mice; D009000:Monocytes / Q000502:physiology*; D012486:Salmonella typhimurium / Q000276:immunology; D014349:Trypanosoma cruzi / Q000276:immunology
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor