[Use of pseudomonas immunoglobulin. Indications and results].
In comparison with polyvalent immunoglobulins, Pseudomonas immunoglobulin (Psomaglobin) is enriched several times in antibodies to Ps. lipopolysaccharide antigens and exotoxin A as well as lipid A. The resulting protective action which is superior to polyvalent immunoglobulins in infections with Pseudomonas, was demonstrated both in cell culture (protection against cytotoxicity of Ps. exotoxin A in heart muscle cells) and in animal models of sepsis. In patients suffering from Ps. pneumonia and Ps.-sepsis clinical improvement is seen after application of this immunoglobulin and also in quantifiable by scoring systems, the unequivocal proof of lowering lethality by using this specific immunoglobulin in Pseudomonas infection is to be shown however.
Werdan
K
K
Medizinische Klinik I der Universität München.
Melnitzki
S
S
Pilz
G
G
Reuschel-Janetschek
E
E
D003422:Critical Care; D005260:Female; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000628:therapy*; D011015:Pneumonia, Aspiration / Q000628:therapy; D011552:Pseudomonas Infections / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012121:Respiration, Artificial; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy
Einsatz von Pseudomonas-Immunglobulin. Indikationen und Ergebnisse.