Low-dose vs high-dose intravenous methylprednisolone therapy for acute renal allograft rejection in patients receiving cyclosporin therapy.
Three mg/kg bodyweight per day of intravenous methylprednisolone for 3 consecutive days is as effective as 15 mg/kg bodyweight per day of methylprednisolone in reversing acute renal allograft rejection (80% vs 68%; 95% confidence intervals of the difference are -8% to 32%). This dose was not associated with an increased incidence of further rejection episodes. It may not be necessary to continue with the common practice of administering high-dose intravenous methylprednisolone for acute renal graft rejection.
Lui
S F
SF
Department of Nephrology and Transplantation, Royal Free Hospital, Hampstead, London, UK.
Sweny
P
P
Scoble
J E
JE
Varghese
Z
Z
Moorhead
J F
JF
Fernando
O N
ON
D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*; D011897:Random Allocation
D003524:Cyclosporins; D008775:Methylprednisolone