[Contribution of perindopril to the treatment of chronic congestive cardiac insufficiency. Multicenter pilot double blind study versus placebo].
Cardiac decompensation occurred in three patients of the placebo group, but not in the perindopril group. The effectiveness of perindopril in heart failure was demonstrated by the improvement observed in exercise test and severity score and by the decrease of cardiothoracic ratio. Changes in SAP, and serum creatinine levels, in particular, showed that the drug was well tolerated.
Bounhoure
J P
JP
CHU de Rangueil, Toulouse, France.
Bottineau
G
G
Lechat
P
P
Garnham
J
J
Lapeyre
G
G
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D020913:Perindopril; D010865:Pilot Projects; D011897:Random Allocation
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D020913:Perindopril
Apport du perindopril au traitement de l'insuffisance cardiaque chronique congestive. Etude pilote multicentrique en double aveugle contre placebo.