[Vibration-induced inactivation of insulin].
A case of diabetic ketoacidosis precipitated by employment of flocculated, and thus inactivated, insulin is presented. The flocculation is presumed to have been produced by vibrations which are presumed to make slow-action insulin form insoluble fibrils at room temperature. This mechanism is recognized in rapid-action insulin.
Mathiassen
B
B
D000328:Adult; D016883:Diabetic Ketoacidosis / Q000209:etiology; D004355:Drug Stability; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D014732:Vibration
D007328:Insulin
Vibrationsinduceret insulin-inaktivering.