Dose-dependent reduction by Ro 15-4513 in mice of the effects of ethanol and some other general depressant drugs.
In mice, Ro 15-4513 reduced the anaesthesia induced by ethanol and some other general depressant drugs, but was less effective against others. The order of potency was, from greatest reduction to least, ethanol, t-butanol, trichloroethanol, urethane, chlormethiazode, pentobarbitone. Of the two gaseous anaesthetics that were tested, ether anaesthesia was reduced but halothane was not. These results appeared independent of the doses of depressant or of Ro 15-4513; the effect of Ro 15-4513 in reducing ethanol anaesthesia was blocked by flumazenil (Ro 15-1788). It would appear that the benzodiazepine receptor complex is of importance in the induction of anaesthesia, most significantly with ethanol and to a diminishing degree with the other general depressants tested.
Bishop
B E
BE
Department of Pharmacology, University of Otago Medical School, Dunedin, New Zealand.
Laverty
R
R
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors*; D005442:Flumazenil / Q000494:pharmacology; D051379:Mice; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000777:Anesthetics; D001386:Azides; D002492:Central Nervous System Depressants; D001569:Benzodiazepines; D000431:Ethanol; D005442:Flumazenil; C042957:Ro 15-4513