title: Clinical trial of norfloxacin in the treatment of uncomplicated gonococcal urethritis: preliminary report.
abstract: Fifteen male outpatients with uncomplicated gonococcal urethritis were treated by a single oral dose of norfloxacin (800 mg). Fourteen patients completely recovered from infection and a recurrence was noted in only one. Five of the Neisseria gonorrhoeae isolated (33.3%) were penicillin-resistant. However, the extremely low MICs confirm that norfloxacin possesses high antibacterial activity against N. gonorrhoeae. Norfloxacin was well tolerated with only a transient nausea occurring in four patients.
authors.affiliation: Institute of Internal Medicine, 1st Medical School, Naples University, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cristiano
mesh_terms: D000328:Adult; D006069:Gonorrhea / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D009643:Norfloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D010403:Penicillin Resistance; D014526:Urethritis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D009643:Norfloxacin