Anti-A in factor VIII concentrate: a cause of severe hemolysis in a patient with acquired factor VIII:C antibodies.
The authors report a case of acute macrohematuria in a patient with spontaneously acquired antibodies against factor VIII:C. Severe hemolysis was observed under factor VIII concentrate therapy. In 4 batches of the factor VIII concentrate high titers up to 1:512 of 'immune' anti-A were found. Clotting factor preparations used for replacement therapy, therefore, should be investigated for iso-antibodies, at least in situations where an intensive infusion therapy is required.
Hach-Wunderle
V
V
Department of Angiology, University Hospital, Frankfurt/M., FRG.
Teixidor
D
D
Zumpe
P
P
Kühnl
P
P
Scharrer
I
I
D000017:ABO Blood-Group System / Q000276:immunology*; D000368:Aged; D000743:Anemia, Hemolytic / Q000276:immunology*; D000906:Antibodies / Q000032:analysis*; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D005169:Factor VIII / Q000008:administration & dosage / Q000276:immunology*; D006417:Hematuria / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008297:Male
D000017:ABO Blood-Group System; D000906:Antibodies; D000941:Antigens; D007518:Isoantibodies; D005169:Factor VIII