Reduced sensitivity of human platelets to PAF-acether following ticlopidine intake.
We investigated in 9 patients the effect of a 7-day treatment by Ticlopidine (250 mg b.i.d.) on washed platelets activation by PAF-acether in comparison with adenosine 5'-diphosphate (ADP) and arachidonic acid (AA). Aggregations induced by ADP were totally suppressed upon drug administration. AA-induced aggregations were partly but significantly inhibited (p less than 0.05). Responses of platelets to PAF-acether before treatment differed from patient to patient. A paired Student's test and a two-way analysis of variance showed a significant inhibitory effect of Ticlopidine treatment on PAF-acether-induced aggregation. The inhibitory effect of Ticlopidine or its metabolite(s) was evidenced after platelet washing procedure, suggesting a persistent effect of this drug on platelet after administration of the drug has been stopped.
Chignard
M
M
INSERM U. 200, Université Paris-Sud, Clamart, France.
Lalau Keraly
C
C
Delautier
D
D
Sebag
C
C
Bouloux
C
C
Motte
G
G
Benveniste
J
J
D000244:Adenosine Diphosphate; D000284:Administration, Oral; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D006801:Humans; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects*
D001095:Arachidonic Acids; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D013988:Ticlopidine