Anticardiolipin antibodies in patients with infectious diseases.
IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.
Santiago
M B
MB
Department of Rheumatology, School of Medicine, University of São Paulo, Brazil.
Cossermelli
W
W
Tuma
M F
MF
Pinto
M N
MN
Oliveira
R M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D004247:DNA / Q000276:immunology; D004697:Endocarditis, Bacterial / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007239:Infections / Q000276:immunology*; D007918:Leprosy / Q000276:immunology; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000276:immunology
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D004247:DNA