[Biological availability of glycerol trinitrate after sublingual administration].
The relative bioavailability of a glyceryl trinitrate (GTN) spray (Nitro-Corangin Spray) compared to that of another GTN Spray was evaluated in 12 healthy male volunteers using an open, randomized cross-over design with two treatment phases. The parameters Cmax, tmax and AUC0-1 showed no statistically significant differences between the two treatments. It is concluded that the two GTN-Sprays may be considered bioequivalent.
Rietbrock
N
N
Abteilung für Klinische Pharmakologie des Klinikums, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
Herling
C
C
Muck
B
B
D000286:Administration, Sublingual; D000328:Adult; D001682:Biological Availability; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation
D005996:Nitroglycerin
Bioverfügbarkeit von Glyceroltrinitrat nach sublingualer Applikation.