Therapy for systemic juvenile rheumatoid arthritis with gamma-interferon: a pilot study of nine patients.
Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage.
Pernice
W
W
Department of Pediatrics, University of Freiburg, Federal Republic of Germany.
Schuchmann
L
L
Dippell
J
J
Suschke
J
J
Vogel
P
P
Truckenbrodt
H
H
Schindera
F
F
Humburg
C
C
Brzoska
J
J
D001171:Arthritis, Juvenile / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D010865:Pilot Projects; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D007371:Interferon-gamma