title: HPLC determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and in biological fluids.
abstract: Two HPLC methods for determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and in biological fluid are reported. Both methods show good linearity, precision, accuracy and reproducibility. The serum levels and urinary excretion of tetroxoprim and sulphadiazine in man, after oral administration of two different syrup formulations, are reported. Tetroxoprim embonate, an insoluble salt very useful for obtaining a suspension with good palatability, shows a bioavailability not statistically different from that of tetroxoprim base. Sulphadiazine shows the same bioavailability in the two syrups.
authors.affiliation: Research Laboratories, Proter S.p.A., Opera, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Springolo
authors.forename: G
authors.initials: G
authors.lastname: Coppi
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000032:analysis* / Q000097:blood / Q000652:urine; D013056:Spectrophotometry, Ultraviolet; D013411:Sulfadiazine / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines; D013411:Sulfadiazine; C023507:tetroxoprim