Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats.
Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.
Dilsaver
S C
SC
Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210-1228.
Normile
H J
HJ
Altman
H J
HJ
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D004357:Drug Synergism; D008297:Male; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D010133:p-Chloroamphetamine / Q000633:toxicity
D000928:Antidepressive Agents; D010095:Oxotremorine; D010133:p-Chloroamphetamine; C025293:alaproclate; D000409:Alanine