Neutron fibre diffraction study of DNA hydration.
Interactions with water are crucial to the conformation assumed by the DNA double helix. The location of water around the D conformation has been investigated in a neutron fibre diffraction study which shows that water is ordered in the minor groove of the DNA. The D conformation is important since its occurrence is limited to specific DNA base pair sequences which have been identified as functionally significant. This study is of particular interest because the D conformation has not been reported in single crystal studies of oligonucleotides.
Forsyth
V T
VT
Department of Physics, University of Keele, Staffordshire, UK.
Mahendrasingam
A
A
Pigram
W J
WJ
Greenall
R J
RJ
Bellamy
K
K
Fuller
W
W
Mason
S A
SA
D004247:DNA / Q000737:chemistry*; D005583:Fourier Analysis; D009502:Neutrons; D009690:Nucleic Acid Conformation; D014867:Water / Q000737:chemistry
D014867:Water; D004247:DNA