Kg, a new low-frequency red cell antigen responsible for hemolytic disease of the newborn.
Hemolytic disease of the newborn in a Japanese infant led to studies which indicate that an antibody detected in the maternal serum is recognizing a hitherto unknown red cell antigen. The antigen, which we have named Kg, was found in two generations of the family and it is inherited as a Mendelian dominant character. The maternal serum failed to react with the red cells of more than 600 random Japanese blood donors, 64 red cell samples known to possess low-frequency antigens and all but one of 75 red cell samples known to lack high-frequency antigens without recognized low-frequency antigens. The father's red cells were tested extensively for established low-frequency antigens; only Dia was demonstrated and the maternal antibody was shown not to contain anti-Dia.
Ichikawa
Y
Y
Blood Transfusion Center, Saitama Medical School Hospital, Japan.
Sato
C
C
McCreary
J
J
Lubenko
A
A
D000017:ABO Blood-Group System; D004899:Erythroblastosis, Fetal / Q000209:etiology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D008951:MNSs Blood-Group System; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D007519:Isoantigens; C060224:Kg, red cell antigen; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System