title: Continuous transtracheal oxygen delivery during cardiopulmonary resuscitation. An alternative method of ventilation in a canine model.
abstract: Adequate oxygenation of apneic subjects can be maintained by constant flow transtracheal oxygen (TTO), but this method alone is associated with hypercapnia. The "bellows" effect of external chest compressions (ECC) might prevent this problem if the airway were kept open by TTO. In dogs, we investigated the utility of TTO delivered at 15 L/min by a percutaneously placed intratracheal catheter, plus ECC (TTO/ECC) as an alternative method of ventilation during CPR. TTO was applied to anesthetized, paralyzed dogs in normal sinus rhythm (NSR) at various rates of ECC and during ventricular fibrillation (VF) at an ECC rate of 80/min. During NSR and VF, hypercapnia did not develop and arterial oxygen saturations were maintained above 90 percent. During NSR, the PaCO2 decreased and the pH increased as the ECC rate increased. For many of the animals, coronary perfusion pressure remained above 20 mm Hg during VF, suggesting that these animals could be resuscitated to NSR. In another phase, after 15 min of VF using TTO/ECC, seven of nine animals were defibrillated. We conclude that ventilatory and hemodynamic support adequate to permit successful resuscitation to NSR is provided by the combination of TTO/ECC to apneic dogs during VF.
authors.affiliation: Section of Pulmonary Medicine, Veterans Administration Medical Center, Tucson 85723.
authors.forename: F K
authors.initials: FK
authors.lastname: Branditz
authors.forename: K B
authors.initials: KB
authors.lastname: Kern
authors.forename: S C
authors.initials: SC
authors.lastname: Campbell
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003326:Coronary Circulation; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D007442:Intubation, Intratracheal / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D011677:Punctures; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012151:Resuscitation / Q000379:methods
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen