Activity of pp60c-src protein kinase in human breast cancer.
Because there is elevation of pp60c-src activity in breast carcinoma tissue, we analyzed primary breast cancer tissue samples from 30 women to determine whether pp60c-src activity correlated with specific clinical parameters. We found that tumors with a progesterone receptor had higher pp60c-src activity than tumors without such a receptor. But there was no association of pp60c-src activity with the presence of an estrogen receptor or of nodes, or with menopausal status or age. The function of pp60c-src in normal cells and in breast cancer is unknown, as is the significance of our finding of an association of elevated pp60c-src activity and the presence of progesterone receptors.
Lehrer
S
S
O'Shaughnessy
J
J
Song
H K
HK
Levine
E
E
Savoretti
P
P
Dalton
J
J
Lipsztein
R
R
Kalnicki
S
S
Bloomer
W D
WD
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D015688:Oncogene Protein pp60(v-src); D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012191:Retroviridae Proteins / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012191:Retroviridae Proteins; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)