Avian thymic hormone (ATH) is a parvalbumin.
Amino acid sequence analysis of a protein from chicken thymus tissue which promotes immunological maturity in chicken bone marrow cells in culture has established sequences of a 45-residue fragment, a 24-residue fragment and a 9-residue and an 8-residue peptide. Independent comparison of the 45- and 24-residue fragments with known amino acid sequences by computer search has unequivocally identified avian thymic hormone as a parvalbumin. This is the first demonstration that a protein previously identified by a biological function is a parvalbumin.
Brewer
J M
JM
Department of Biochemistry, University of Georgia, Athens 30602.
Wunderlich
J K
JK
Kim
D H
DH
Carr
M Y
MY
Beach
G G
GG
Ragland
W L
WL
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D002918:Chymotrypsin; D007256:Information Systems; D008969:Molecular Sequence Data; D009124:Muscle Proteins; D010320:Parvalbumins; D010434:Pepsin A; D010446:Peptide Fragments; D012689:Sequence Homology, Nucleic Acid; D013950:Thymus Gland / Q000032:analysis; D013951:Thymus Hormones; D014357:Trypsin
D009124:Muscle Proteins; D010320:Parvalbumins; D010446:Peptide Fragments; D013951:Thymus Hormones; D002918:Chymotrypsin; D014357:Trypsin; D010434:Pepsin A