[Effect of aflatoxin B1 on DNA enzymatic methylation and secondary structures of the rat liver].
Methylation and secondary structure of DNA in rat liver versus time of aflatoxin B1 (AfB1) treatment were studied. A 50% drop in 5-methylcytosine level in liver DNA as compared with control was observed long before tumor development. Also, certain changes in DNA secondary structure were seen. The DNA changes were more pronounced in the F1 progeny of rats inoculated with AfB1 at the terminal stage of gestation.
Aslanian
V M
VM
Babaian
Iu S
IuS
Arutiunian
S G
SG
Garibzhanian
B T
BT
Danielian
I S
IS
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001482:Base Composition / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology*; D004247:DNA / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004126:Dimethylformamide / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008745:Methylation; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry
D000348:Aflatoxins; D002273:Carcinogens; D004126:Dimethylformamide; D004247:DNA; D016604:Aflatoxin B1
Vliianie aflatoksina B1 na fermentativnoe metilirovanie i vtorichnuiu strukturu DNK v pecheni krys.