Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of sulphur-containing amino acids.
Sulphur-containing amino acids including some derivatives have been tested for their effectiveness in suppressing the mutagenic activity of aflatoxin B1 in Salmonella typhimurium strains provided with a rat liver activation system. Cysteine and N-acetylcysteine have been found to be most effective in the 2 strains tested (TA100 and TA98). Glutathione (oxidised and reduced forms) has shown partial activity, while cystine and methionine are found to be partially effective only in strain TA100. Inhibition of mutagenicity may be due to interaction of these substances with microsomal enzymes resulting in interference with the formation of ultimate mutagenic species.
Shetty
T K
TK
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Francis
A R
AR
Bhattacharya
R K
RK
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects
D000348:Aflatoxins; D000603:Amino Acids, Sulfur; D016604:Aflatoxin B1