title: [Anal canal carcinoma: diagnosis--therapy--prognosis].
abstract: 78 patients with anal canal carcinoma were treated between 1970 and 1988 at the University Hospital Erlangen. 48 patients (35 women, 13 men) were treated by surgery alone, 44/48 by abdominoperineal resection, 4/48 by local excision. Median age was 63 years, median follow-up 8.5 years. The overall local recurrence rate was 16.7%, the overall five-year-survival was 51%. 30 patients received a combined radio-chemotherapy. The small pelvis was treated with a.-p./p.-a. fields up to a total dose between 42 and 50 Gy. Two courses of chemotherapy consisting of 5-FU (800 to 1000 mg/m2 days 1 to 4 and 29 to 32) and Mitomycin C (10 mg/m2 days 1 and 29) were administered. Two months after completion of treatment 83% had a biopsy proven complete remission. After a median follow-up of 15 months 87% are alive with NED, 74% are continent. The combined regimen of radio-chemotherapy is considered as the treatment of the choice for anal canal carcinoma. Abdominoperineal resection is only performed in patients with non response or local recurrent disease.
authors.affiliation: Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg.
authors.forename: G G
authors.initials: GG
authors.lastname: Grabenbauer
authors.forename: N
authors.initials: N
authors.lastname: Wolf
authors.forename: J
authors.initials: J
authors.lastname: Dunst
authors.forename: R
authors.initials: R
authors.lastname: Sauer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011379:Prognosis; D012074:Remission Induction
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil
vernacular_title: Analkanalkarzinom: Diagnostik--Therapie--Prognose.