title: Body burdens of lead in hypertensive nephropathy.
abstract: Chronic lead exposure resulting in blood lead concentrations that exceed 1.93 mumol/l (40 micrograms/dl) or chelatable urinary lead excretion greater than 3.14 mumol (650 micrograms) per 72 h has been associated with renal disease. A previous study had found greater chelatable urine lead excretion in subjects with hypertension and renal failure than in controls with renal failure due to other causes, although mean blood lead concentrations averaged 0.92 mumol/l (19 micrograms/dl). To determine if chelatable urinary lead, blood lead, or the hematologic effect of lead (zinc protoporphyrin) were greater in hypertensive nephropathy (when hypertension precedes elevation of serum creatinine) than in other forms of mild renal failure, we compared 40 study subjects with hypertensive nephropathy to 24 controls having a similar degree of renal dysfunction due to causes other than hypertension. Lead burdens were similar in both the study and control groups as assessed by 72-h chelatable urinary lead excretion after intramuscular injection of calcium disodium EDTA (0.74 +/- 0.63 vs. 0.61 +/- 0.40 mumol per 72 h, respectively), and by blood lead (0.35 +/- 0.23 vs. 0.35 +/- 0.20 mumol/l). We conclude that subjects from a general population with hypertensive nephropathy do not have greater body burdens of lead than renal failure controls.
authors.affiliation: Department of Medicine and Lab Medicine, University of California, San Francisco.
authors.forename: J D
authors.initials: JD
authors.lastname: Osterloh
authors.forename: J V
authors.initials: JV
authors.lastname: Selby
authors.forename: B P
authors.initials: BP
authors.lastname: Bernard
authors.forename: C E
authors.initials: CE
authors.lastname: Becker
authors.forename: D J
authors.initials: DJ
authors.lastname: Menke
authors.forename: E
authors.initials: E
authors.lastname: Tepper
authors.forename: J D
authors.initials: JD
authors.lastname: Ordonez
authors.forename: B
authors.initials: B
authors.lastname: Behrens
mesh_terms: D000368:Aged; D001822:Body Burden; D004492:Edetic Acid / Q000008:administration & dosage; D004781:Environmental Exposure; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism*; D007854:Lead / Q000032:analysis*; D007855:Lead Poisoning / Q000150:complications; D008875:Middle Aged
chemical_list: D007854:Lead; D004492:Edetic Acid