title: Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor.
abstract: The compound eye of the adult fruitfly, Drosophila melanogaster, comprises about 800 identical ommatidia, or unit eyes, each containing 20 distinct cells. We have used histological and immunocytochemical methods to study the development of the compound eye in Ellipse (Elp) mutants. In Elp/Elp, most ommatidia do not initiate differentiation. We present genetic evidence that Elp alleles are mutations of the Drosophila homologue of the epidermal growth factor (EGF) receptor, and suggest that activity of the EGF receptor may determine the spacing pattern of ommatidia in the eye.
authors.affiliation: Howard Hughes Medical Institute, University of California, Berkeley 94720.
authors.forename: N E
authors.initials: NE
authors.lastname: Baker
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002872:Chromosome Deletion; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development*; D004625:Embryo, Nonmammalian; D066246:ErbB Receptors / Q000235:genetics* / Q000502:physiology; D005123:Eye / Q000166:cytology / Q000254:growth & development; D005260:Female; D005799:Genes, Dominant; D008297:Male; D009154:Mutation; D009799:Ocular Physiological Phenomena; D010641:Phenotype; D012689:Sequence Homology, Nucleic Acid
chemical_list: D066246:ErbB Receptors