title: Response of Lactococcus (Streptococcus) lactis to N-methyl-N'-nitro-N-nitrosoguanidine: absence of adaptive response.
abstract: Pretreatment of cells of Lactococcus lactis subsp. lactis with low levels of N-methyl-N'-nitro-N-nitrosoguanidine does not reduce the cytotoxic and mutagenic effects caused by high concentration of this agent. This observation indicates that there is no efficient inducible error-free repair system for alkylation damage similar to the 'adaptive response' described in detail for Escherichia coli.
authors.affiliation: Laboratoire de Génétique Microbienne, Université de Caen, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Auffray
authors.forename: B
authors.initials: B
authors.lastname: Gillot
authors.forename: M
authors.initials: M
authors.lastname: Lautier
authors.forename: B
authors.initials: B
authors.lastname: Thammavongs
authors.forename: P
authors.initials: P
authors.lastname: Boutibonnes
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity; D004249:DNA Damage; D004260:DNA Repair; D013294:Lactococcus lactis / Q000187:drug effects*; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009153:Mutagens; D009154:Mutation; D013014:SOS Response, Genetics
chemical_list: D000477:Alkylating Agents; D009153:Mutagens; D008769:Methylnitronitrosoguanidine