title: Invasive meningococcal disease: secondary spread in a day-care center.
abstract: We have reported the epidemiologic investigation and subsequent control measures precipitated by the occurrence of two temporally related cases of invasive meningococcal disease in a single day-care center classroom. A review of the literature indicates that day-care center contacts of patients with invasive meningococcal disease are at increased risk for secondary spread of infection. Our experience emphasizes the importance of reporting cases to the local health department, implementing rifampin prophylaxis for appropriate contacts, and considering immunization in select circumstances. Rifampin is indicated for all cases of meningococcal disease as well.
authors.affiliation: Department of Pediatrics, University of Tennessee, Memphis.
authors.forename: R J
authors.initials: RJ
authors.lastname: Leggiadro
authors.forename: L M
authors.initials: LM
authors.lastname: Baddour
authors.forename: C E
authors.initials: CE
authors.lastname: Frasch
authors.forename: J F
authors.initials: JF
authors.lastname: LaFrain
authors.forename: S M
authors.initials: SM
authors.lastname: Gaia
authors.forename: J A
authors.initials: JA
authors.lastname: Thomas
mesh_terms: D001428:Bacterial Vaccines; D002656:Child Day Care Centers; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000517:prevention & control / Q000635:transmission*; D022401:Meningococcal Vaccines; D009345:Neisseria meningitidis / Q000302:isolation & purification; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D001428:Bacterial Vaccines; D022401:Meningococcal Vaccines; D012293:Rifampin