title: Pseudomonas aeruginosa infections associated with use of povidone-iodine in patients receiving continuous ambulatory peritoneal dialysis.
abstract: Fifteen episodes of infection due to Pseudomonas aeruginosa, including peritonitis and catheter site infections, occurred in nine patients receiving continuous ambulatory peritoneal dialysis over a 27-month period. Eight episodes were associated with catheter loss. Occurrence of P aeruginosa infection was significantly associated with use of povidone-iodine solution to cleanse the catheter site. There was no association with use of povidone-iodine solution to disinfect tubing connections, use of other skin care products or exposure to other environmental sources of P aeruginosa. Cultures of available povidone-iodine products were negative. Local irritation and alteration in skin flora caused by antiseptic solution or low-level contamination of povidone-iodine solution are potential mechanisms of infection.
authors.affiliation: Department of Medicine, Veterans Administration Medical Center, Pittsburgh, Pennsylvania.
authors.forename: A
authors.initials: A
authors.lastname: Goetz
authors.forename: R R
authors.initials: RR
authors.lastname: Muder
mesh_terms: D002408:Catheters, Indwelling; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011205:Povidone; D011206:Povidone-Iodine / Q000009:adverse effects*; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000209:etiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification
chemical_list: D011206:Povidone-Iodine; D011205:Povidone