[Significance of alanine aminotransferase and reduction of post-transfusion non-A, non-B hepatitis].
To appreciate the test based on the activity of sera alanine aminotransferase (ALT) in the reduction of non-A non-B post-transfusional hepatitis, a study of the variation of this enzyme's activity was done versus several parameters: sex, age and acquired diseases. The population which included 25,813 Parisian blood donors (41.2% of men and 58.8% of women) was divided into two groups: the first was constituted of 25,585 subjects (40.9% of men and 59.1% of women) without clinical etiology and biological diseases, it will be the reference population; the second group was composed of 173 subjects (68.2% of men and 31.8% of women) who had acquired biological markers or clinical diseases during the life. The study within the reference population showed a sexual dimorphism. The study by dispersion diagrams in the population with high seric activity of ALT could explain the causes of blood donors' elimination.
Hoang
B
B
Centre de Transfusion sanguine, Hôpital Broussais-la Charité, Paris.
Simonneau
M
M
Le Xuan
P
P
Guichoux
P
P
Terrier
E
E
Ruffie
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001782:Blood Donors; D004796:Clinical Enzyme Tests; D005260:Female; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006526:Hepatitis C / Q000175:diagnosis / Q000517:prevention & control* / Q000635:transmission; D006525:Hepatitis, Viral, Human / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012737:Sex Factors; D065227:Transfusion Reaction
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D000410:Alanine Transaminase
Valeur de l'alanine aminotransférase et réduction des hépatites non-A non-B post-transfusionnelles.