Light-chain nephropathy. A report of 2 cases.
Two cases of renal impairment caused by the deposition of monoclonal immunoglobulin light-chain determinants in the glomerular mesangium and basement membranes as well as in the tubular basement membranes of the kidney are described (light-chain nephropathy). Both cases were associated with myeloma. Examinations by light microscopy, immunohistochemistry and electron microscopy are also described. Differential diagnoses on light microscopy include diabetic glomerulosclerosis (Kimmelstiel-Wilson lesions), amyloidosis and mesangiocapillary glomerulonephritis type 1.
Cooper
K
K
Department of Anatomical Pathology, University of Natal and King Edward VIII Hospital, Durban.
Nathoo
B C
BC
D000328:Adult; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000209:etiology*; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D012598:Sclerosis
D007147:Immunoglobulin Light Chains