title: Pulsatile gonadotropin secretion in pubertal children with chronic renal failure.
abstract: We have examined physiological nocturnal secretion of gonadotropins in 6 boys and 2 girls with end-stage renal disease, who had either delayed or disturbed puberty. The 5 patients treated by dialysis had reduced gonadotropin pulsatility for their stage of pubertal maturation, whereas the 3 patients with successful kidney grafts demonstrated a higher nocturnal rise and increased amplitude of gonadotropin pulsatility. It is suggested that the improved gonadotropin pulsatility of transplanted patients is due to their restored renal function.
authors.affiliation: Section of Endocrinology, University Children's Hospital, Heidelberg, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Schaefer
authors.forename: R
authors.initials: R
authors.lastname: Stanhope
authors.forename: H
authors.initials: H
authors.lastname: Scheil
authors.forename: D
authors.initials: D
authors.lastname: Schönberg
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
authors.forename: K
authors.initials: K
authors.lastname: Schärer
mesh_terms: D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D016030:Kidney Transplantation; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011627:Puberty / Q000097:blood / Q000502:physiology*; D011628:Puberty, Delayed / Q000097:blood / Q000503:physiopathology; D006435:Renal Dialysis
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone