Thyrotropin-releasing hormone (TRH) evokes chloride secretion via cholinergic pathways in the guinea-pig ileum.
The effect of thyrotropin-releasing hormone (TRH) on ion transport in the guinea-pig ileum was investigated in flux chambers. TRH evoked a concentration-dependent increase in short-circuit current that was due to active anion secretion. The response to TRH was prevented by tetrodotoxin and nearly abolished by atropine, but was not affected by mecamylamine. The results suggest that TRH plays a role as a neuromodulator or neurotransmitter that influences secretory processes by directly or indirectly activating cholinergic motor neurons.
Carey
H V
HV
Department of Physiology, College of Medicine, Ohio State University, Columbus 43210.
Cooke
H J
HJ
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002034:Bumetanide / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000294:innervation; D066298:In Vitro Techniques; D008464:Mecamylamine / Q000494:pharmacology; D009434:Neural Pathways / Q000378:metabolism; D010275:Parasympathetic Nervous System / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D002712:Chlorides; D002034:Bumetanide; D012701:Serotonin; D013779:Tetrodotoxin; D013973:Thyrotropin-Releasing Hormone; D008464:Mecamylamine; D001285:Atropine