Enhancing effect of tetrandrine on sister-chromatid exchanges induced by mitomycin C and cigarette-smoke condensate in mammalian cells.
The enhancing effect of tetrandrine, an antisilicosis, antitumor and antiinflammatory drug, on the genotoxic activity of two known mutagens, mitomycin C (MMC) and cigarette-smoke condensate (CSC), has been studied using cultured Chinese hamster lung (V79) cells. The sister-chromatid exchange (SCE) was used as genetic endpoint to measure genotoxicity. One-day cultured cells were exposed to the test chemicals for 3 h with or without metabolic activation. The results show that the frequencies of SCE induced by MMC or CSC were enhanced by tetrandrine. The percent of enhancement was dependent on the concentration of tetrandrine.
Xing
S G
SG
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV.
Wu
Z L
ZL
Whong
W Z
WZ
Ong
T
T
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D044182:Benzylisoquinolines; D001711:Biotransformation; D002460:Cell Line; D006224:Cricetinae; D004357:Drug Synergism; D066298:In Vitro Techniques; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity*; D009152:Mutagenicity Tests; D010947:Plants, Toxic; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012906:Smoke; D014026:Nicotiana
D000470:Alkaloids; D044182:Benzylisoquinolines; D008937:Mitomycins; D012906:Smoke; C009438:tetrandrine; D016685:Mitomycin