Polyamine interaction with Z-DNA.
In order to elucidate the detailed Z-DNA interaction with polyamines and also to clarify the mutual molecular recognition between the left-handed helix and the biologically important polyamine molecule, several polyamine-Z-DNA hexamer complexes were crystallized and their crystal structures were determined by X-ray diffraction. The general interaction modes found in these crystal structures were discussed in comparison with those in the complexes between polyamine and the right-handed DNA or RNA.
Tomita
K
K
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Hakoshima
T
T
Inubushi
K
K
Kunisawa
S
S
Ohishi
H
H
van der Marel
G A
GA
van Boom
J H
JH
Wang
A H
AH
Rich
A
A
D003460:Crystallization; D004247:DNA / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D011073:Polyamines / Q000378:metabolism*; D014961:X-Ray Diffraction
D011073:Polyamines; D004247:DNA