Cyanide-induced parkinsonism: clinical, MRI, and 6-fluorodopa PET studies.
A 46-year-old man ingested 1,500 mg of potassium cyanide in a suicide attempt. He survived, but later developed a severe parkinsonian syndrome. MRI revealed multiple areas of low-signal intensity in the globus pallidus and posterior putamen. A 6-fluorodopa PET study revealed bilateral decreased uptake in the basal ganglia. This evidence of functional impairment of dopaminergic nigrostriatal neurons is related either to direct toxicity of cyanide or to the effects of cerebral hypoxia secondary to cyanide intoxication.
Rosenberg
N L
NL
Research Service, Veterans Administration Medical Center, Denver, CO 80220.
Myers
J A
JA
Martin
W R
WR
D003486:Cyanides / Q000506:poisoning*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D011190:Potassium Cyanide / Q000506:poisoning*; D013406:Suicide, Attempted; D014055:Tomography, Emission-Computed
D003486:Cyanides; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D011190:Potassium Cyanide