title: Possible effectiveness of plasmapheresis and immunosuppressive therapy in reversing subcutaneous insulin resistance: a case report.
abstract: Severe resistance to subcutaneous insulin with normal sensitivity to intravenous insulin developed in a 39 year old woman affected by type 1 diabetes mellitus. The patient had been treated for ten months with continuous intravenous or intraperitoneal insulin before undergoing pancreatic transplantation. After surgery repeated plasmapheresis were performed and immunosuppressive therapy was undertaken. When studied again, one month after surgery, the patient showed normal sensitivity to subcutaneous insulin. Our data suggest that plasmapheresis and/or immunosuppressive treatment could have played a role in reversing insulin resistance.
authors.affiliation: Cattedra e Servizio di Malattie del Ricambio e Diabetologia, Policlinico S. Orsola, Bologna, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Vannini
authors.forename: G
authors.initials: G
authors.lastname: Forlani
authors.forename: S
authors.initials: S
authors.lastname: Giangiulio
authors.forename: G
authors.initials: G
authors.lastname: Santacroce
authors.forename: A
authors.initials: A
authors.lastname: Ciavarella
authors.forename: A
authors.initials: A
authors.lastname: Mustacchio
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007333:Insulin Resistance; D061389:Insulin, Regular, Pork; D016381:Islets of Langerhans Transplantation; D010956:Plasmapheresis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D007328:Insulin; D061389:Insulin, Regular, Pork; D011994:Recombinant Proteins; C000006:insulin, neutral