[Effect of muskrat on the cardiovascular system in anesthetized dogs].
Muskrat and musk are secretions from the fragrant glands of male adult musk-rat (Ondatra zibethica) and musk-deer respectively. In this paper, the pharmacological effects of muskrat and musk are studied. The result shows that a dose of 24 mg/kg iv of muskrat or musk can decrease the HR, mAP, LVP, LVdp/dt max and TPR in anesthetized dogs. But muskrat has an effect of reducing MHO while musk has not. In addition, an injection of 120 mg/kg of muskrat or musk endures hypoxia in mice. But this function of muskrat was weaker than that of musk.
Chen
Y S
YS
Jin
S D
SD
Dong
W C
WC
Tong
Y R
YR
Hua
S F
SF
Zhao
H Y
HY
D000818:Animals; D003411:Arvicolinae; D003670:Deer; D004285:Dogs; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption
D005229:Fatty Acids, Monounsaturated; C008563:musk