title: Comparative aspects of congener specific PCB metabolism.
abstract: Despite the large number of PCB congeners identified (in some environmental samples more than 70 isomers and congeners) only some 12 of them account for 80% of the total PCB adipose tissue burden. These compounds are a selective group of PCBs which are highly chlorinated or alternatively lack meta-para-vicinal protons. Comparison of the persistent and non-persistent PCB congeners between human adipose tissue, human breast milk and fish-eating sea birds revealed similarities in the bioaccumulation pattern. These findings suggest a certain inability of cytochrome P-450 mono-oxygenases to metabolise a specific group of PCBs.
authors.affiliation: Department of Biochemistry and Physiology, University of Reading, U.K.
authors.forename: J T
authors.initials: JT
authors.lastname: Borlakoglu
authors.forename: C H
authors.initials: CH
authors.lastname: Walker
mesh_terms: D000818:Animals; D001717:Birds / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007536:Isomerism; D011078:Polychlorinated Biphenyls / Q000378:metabolism*
chemical_list: D011078:Polychlorinated Biphenyls