[5,6-bis-(3-alkoxy-carbonyl thio-ureido) benzimidazoles with anthelmintic activity].
The reaction of potassium thiocyanate with the methyl- and ethyl esters of chloroformic acid (V-VI) in acetone resulted in methoxy- and ethoxycarbonylisothiocyanates which were converted without isolation by means of an addition reaction with 2-alkyl-5,6-diaminobenzimidazoles (I-IV) into the pertinent 2-alkyl-5,6-bis (3-alkoxycarbonyl-2-thioureido) benzimidazoles (VII-XV). The substances obtained were tested for anthelmintic and anticoccidial effectiveness. In anthelmintic screening, substances VIII, IX, XI, XII, XIV and XV were significantly effective against the taenia Hymenolepis nana.
Sluka
J
J
Zikán
V
V
Danĕk
J
J
D000818:Animals; D000871:Anthelmintics; D001562:Benzimidazoles / Q000494:pharmacology; D006926:Hymenolepis / Q000187:drug effects; D051379:Mice; D009559:Nippostrongylus / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology
D000871:Anthelmintics; D001562:Benzimidazoles; D013890:Thiourea
5,6-bis(3-alkoxykarbonylthioureido) benzimidazoly s anthelmintickou úcinností.