title: [Preliminary study of the use of intranasal buserelin in the long-term protocol of ovarian stimulation with the view toward fertilization in vitro].
abstract: A study conducted in 22 patients who used intranasal buserelin, in a long-term protocol for IVF, showed that pituitary desensitization is obtained between 14 days and 1 month. Analysis of the trials in this series, where the results were not satisfactory, suggests that the bioavailability of the product used intranasally, may be in question. A better distribution of nasal sprays causes more discomfort than when used subcutaneously.
authors.affiliation: Centre de Gynécologie-Obstétrique, CHU, Amiens.
authors.forename: B
authors.initials: B
authors.lastname: Camier
authors.forename: O
authors.initials: O
authors.lastname: Gagneur
authors.forename: S
authors.initials: S
authors.lastname: Arlot
authors.forename: F
authors.initials: F
authors.lastname: Thépot
authors.forename: M
authors.initials: M
authors.lastname: Vitse
mesh_terms: D000281:Administration, Intranasal; D001682:Biological Availability; D002064:Buserelin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*
chemical_list: D002064:Buserelin
vernacular_title: Etude préliminaire de l'utilisation de la busereline par voie nasale dans le protocole long de stimulation ovarienne en vue de fécondation in vitro.