[Synthesis of N-(4-carbethoxy-4-substituted butyryl)-N-substituted glycines].
This paper reports the synthesis of nine N-(4-carbethoxy-4-substituted butyryl)-N-substituted glycines and their corresponding t-butyl esters. The former were expected to have inhibitory activity of angiotensin-converting enzyme. All of the compounds mentioned above were unreported in the literature. In preliminary test in rats, compounds VII7 and VII9 showed marked hypotensive activity.
Chen
Y M
YM
Cai
C Y
CY
Gong
K S
KS
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains
D000806:Angiotensin-Converting Enzyme Inhibitors; D005998:Glycine