Alternative T cell receptor gene usage induced by self tolerance.
Ab-restricted, H-Y-specific T cell clones from C57BL/6 mice were found to use predominantly V beta 6 T cell receptor genes, conferring Mls-1a reactivity. However, the expression of Mls-1a as a self antigen in (DBA/2 x C57BL/6)F1 mice did not turn these mice into nonresponders to H-Y. Instead of V beta 6, they used other T cell receptor genes in this response. Thus, self tolerance appears to bias the repertoire of T cell receptor genes used in response to foreign antigens, without necessarily impairing the immune responsiveness to these antigens.
Frangoulis
B
B
Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen.
Pla
M
M
Rammensee
H G
HG
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D006182:H-Y Antigen / Q000276:immunology; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006182:H-Y Antigen; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell