[Blood pressure lability in the sympathectomized rat].
Intra-aortic blood pressure (BP) was measured in conscious rats after early chronic destruction of the peripheral sympathetic nervous system (SNS) with guanethidine. In sympathectomized rats, the mean level of BP was not different from that of control rats but its variability was markedly increased. These results indicate that functional integrity of the SNS is of primary importance for the short-term control of BP but is not essential for its long-term maintenance.
Julien
C
C
Département de Physiologie et Pharmacologie clinique, C.N.R.S.-U.A. n 606, Faculté de Pharmacie, Lyon.
Barres
C
C
Kandza
P
P
Sassard
J
J
D000818:Animals; D001794:Blood Pressure; D006145:Guanethidine; D006339:Heart Rate; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*
D006145:Guanethidine
Labilité de la pression artérielle chez le rat sympathectomisé.