title: Effect of one haemodialysis treatment on the plasma concentrations of intact parathyroid hormone and ionised calcium: usefulness of end-dialysis values in evaluating the suppressibility of hyperparathyroidism.
abstract: We studied the effect of one haemodialysis treatment on the plasma concentrations of intact parathyroid hormone (PTH), total immunoreactive PTH (determined with an antibody against the mid-molecular part of the hormone), and ionised calcium in 25 patients on maintenance dialysis for chronic renal failure. During dialysis the calcium concentration in the external fluid was 1.75 mmol/l, which led to an increase in the plasma ionised calcium concentration from 1.23 +/- 0.07 mmol/l (mean +/- SD) at commencement of dialysis to a final 1.35 +/- 0.07 mmol/l (P less than 0.001). The plasma concentration of intact PTH decreased from 27.4 +/- 26.3 pmol/l to 13.0 +/- 19.1 pmol/l (P less than 0.001) during the treatment. Total immunoreactive PTH did not change, reflecting poor dialysability of PTH and PTH fragments. We also compared the dialysis-induced changes in the plasma concentrations of intact PTH and ionised calcium with those induced by a calcium infusion test. We conclude that in the majority of dialysis patients, one haemodialysis treatment with a relatively high external fluid calcium concentration can be used to assess the suppressibility of secondary hyperparathyroidism.
authors.affiliation: Clinic of Medicine, Tampere University Central Hospital, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Pietilä
authors.forename: J
authors.initials: J
authors.lastname: Mustonen
authors.forename: P
authors.initials: P
authors.lastname: Mörsky
authors.forename: E
authors.initials: E
authors.lastname: Seppälä
authors.forename: A
authors.initials: A
authors.lastname: Pasternack
authors.forename: T
authors.initials: T
authors.lastname: Koivula
mesh_terms: D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000008:administration & dosage; D002118:Calcium / Q000097:blood*; D002119:Calcium Carbonate / Q000008:administration & dosage; D005260:Female; D015312:Hemodialysis Solutions / Q000008:administration & dosage; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D006435:Renal Dialysis
chemical_list: D015312:Hemodialysis Solutions; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D000536:Aluminum Hydroxide; C046111:parathyroid hormone (44-68); D002119:Calcium Carbonate; D002118:Calcium