Rioprostil prevents aspirin-induced fecal blood loss in dogs. Correlation of Hemoquant (Hb) with endoscopic findings.
Rioprostil, a primary alcohol prostaglandin E1 analog, prevents gastric lesion formation induced by a variety of irritants, including aspirin, in rats and dogs. In the present study, rioprostil reduced both gastric lesion formation and fecal blood loss in dogs caused by daily aspirin administration (1,950 mg/day) for 3 consecutive days. A gastric antisecretory dose of 100 micrograms/kg p.o. t.i.d. of rioprostil reduced fecal blood loss by 96% to a level (0.76 +/- 0.10 mg Hb/g stool) similar to basal blood loss in non-aspirin-treated vehicle dogs (0.61 +/- 0.08 mg Hb/g stool) as determined by HemoQuant assay. A nonantisecretory dose of rioprostil (1 microgram/kg p.o. t.i.d.) reduced fecal blood loss by 70% compared to vehicle-treated dogs. Gastric lesion severity scores in dogs treated with 100 or 1 micrograms/kg p.o. t.i.d. of rioprostil were 61 and 52% lower, respectively, than the mean severity score in the vehicle-treated group. There was a highly significant (p less than 0.001) correlation between gastric lesion score and fecal blood loss independent of the treatment each dog received. The efficacy of a nonantisecretory dose suggests that the gastric lesion effect of rioprostil may be independent of gastric antisecretory effects. The correlation of fecal blood loss with gastric lesion score suggests the possibility that either measurement may be used as an indication of gastric lesion occurrence or severity.
Katz
L B
LB
R.W. Johnson Pharmaceutical Research Institute, Ortho Pharmaceutical Corporation, Raritan.
Fernandez
J A
JA
Schwartz
S
S
Shriver
D A
DA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000517:prevention & control; D005773:Gastroscopy; D008297:Male; D009780:Occult Blood; D011458:Prostaglandins E / Q000627:therapeutic use*; D016630:Rioprostil; D013272:Stomach Diseases / Q000139:chemically induced* / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D016630:Rioprostil; D001241:Aspirin