title: [Biological availability of glycerol trinitrate after sublingual administration].
abstract: The relative bioavailability of a glyceryl trinitrate (GTN) spray (Nitro-Corangin Spray) compared to that of another GTN Spray was evaluated in 12 healthy male volunteers using an open, randomized cross-over design with two treatment phases. The parameters Cmax, tmax and AUC0-1 showed no statistically significant differences between the two treatments. It is concluded that the two GTN-Sprays may be considered bioequivalent.
authors.affiliation: Abteilung für Klinische Pharmakologie des Klinikums, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
authors.forename: N
authors.initials: N
authors.lastname: Rietbrock
authors.forename: C
authors.initials: C
authors.lastname: Herling
authors.forename: B
authors.initials: B
authors.lastname: Muck
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D001682:Biological Availability; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation
chemical_list: D005996:Nitroglycerin
vernacular_title: Bioverfügbarkeit von Glyceroltrinitrat nach sublingualer Applikation.