Distributions of tegafur in tissues of gastric adenocarcinoma patients: tissue uptakes and concentrations in plasma after oral and rectal administrations.
Fifty-one gastric adenocarcinoma patients were divided into two groups, according to the route of administration of the anticancer drug. One group was given FT-207 (tegafur, an enteric coated granule) orally and the other group, FT-207 in the form of a suppository. Blood and tissue concentrations of the drug were examined after a three-day administration of 750 mg at 09.00 and 21.00 hours. There were no significant differences between the two groups with respect to the concentrations of FT-207 and its metabolite 5-FU in the tissues. Levels of 5-FU in the excised tumor averaged 0.256 and 0.160 micrograms/g, in oral and rectal administrations, respectively, and levels in normal lymph nodes averaged 0.174 and 0.179 micrograms/g, respectively. The difference in 5-FU levels between normal and tumor tissues was statistically significant (P less than 0.05).
Arima
S
S
Department of Surgery, Chikushi Hospital, School of Medicine, Fukuoka University.
Futami
K
K
Yoshimura
S
S
Shimura
H
H
D000230:Adenocarcinoma / Q000032:analysis* / Q000556:secondary; D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D005260:Female; D005472:Fluorouracil / Q000032:analysis; D006801:Humans; D008198:Lymph Nodes / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000032:analysis; D013274:Stomach Neoplasms / Q000032:analysis*; D013488:Suppositories; D013608:Tablets, Enteric-Coated; D005641:Tegafur / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D014018:Tissue Distribution
D013488:Suppositories; D013608:Tablets, Enteric-Coated; D005641:Tegafur; D005472:Fluorouracil