Lysolecithin concentration in pancreatic tissue during therapy with phospholipase A2-inhibitors in acute necrotizing pancreatitis.
Four hours after hemorrhagic necrotizing pancreatitis was induced in experimental animals the concentration of lysolecithin in pancreatic tissue rose (p = 0.0025). Parenteral administration of unspecific inhibitors of phospholipase A2, such as chlorpromazine, gabexat mesilat and CaNa2 EDTA, can neither inhibit elevation of the enzyme nor influence the course of the disease.
Kahle
M
M
Chirurgische Abteilung, Städtischen Krankenhaus Landshut.
König
H
H
Filler
R D
RD
D000208:Acute Disease; D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use*; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000187:drug effects*; D010195:Pancreatitis / Q000188:drug therapy*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2
D006146:Guanidines; D008244:Lysophosphatidylcholines; D016670:Gabexate; D004492:Edetic Acid; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D002746:Chlorpromazine