title: Extraspinal ependymoma in the sacrococcygeal region. A case report with ultrastructural, immunohistochemical and cytophotometric studies.
abstract: We describe on a primary, subcutaneous sacrococcygeal ependymoma presenting in a young female patient. Detailed immunohistochemical and electron microscopic examinations were performed. Out of the 40 similar cases reported in literature this is the first in which the determination of DNA content was also used to predict biological behaviour. The tumour proved to be aneuploid with low proliferative capacity in spite of absent histological signs of malignancy. It is suggested that DNA determination may be helpful in establishing prognosis and that it may contribute to a better understanding of the biological behaviour of this tumour.
authors.affiliation: National Institute of Oncology, Research Institute of Oncopathology, Budapest, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Sápi
authors.forename: J
authors.initials: J
authors.lastname: Megyesi
authors.forename: I
authors.initials: I
authors.lastname: Besznyák
authors.forename: J
authors.initials: J
authors.lastname: Sugár
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D003050:Coccyx / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000378:metabolism; D004806:Ependymoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D012447:Sacrum / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D013125:Spinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D004273:DNA, Neoplasm