title: Pharmacokinetics of rioprostil in human plasma as assayed by combined capillary gas chromatography-negative ion chemical ionization mass spectrometry.
abstract: To investigate the pharmacokinetics of rioprostil in man an assay is developed to analyse levels of rioprostil in plasma. After extraction and purification by solid-phase cartridges rioprostil is measured by negative ion chemical ionization mass spectrometry using a deuterated internal standard. The method is validated by a recovery experiment. Levels of rioprostil in the plasma of four volunteers following a single oral dose of 600 micrograms rioprostil are found as always below 100 pg/ml. The data presented here suggest that rioprostil is transformed rapidly in man to its more polar metabolites.
authors.affiliation: Medizinische Klinik Innenstadt der Universität München, FRG.
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: H
authors.initials: H
authors.lastname: Schweer
authors.forename: H
authors.initials: H
authors.lastname: Kraft
authors.forename: P
authors.initials: P
authors.lastname: Weber
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000097:blood* / Q000493:pharmacokinetics; D011465:Prostaglandins, Synthetic / Q000097:blood / Q000493:pharmacokinetics; D016630:Rioprostil
chemical_list: D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016630:Rioprostil