Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia.
Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when alpha 2-plasmin inhibitor (alpha 2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients when the alpha 2-PI level has decreased significantly.
Okajima
K
K
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
Koga
S
S
Okabe
H
H
Inoue
M
M
Takatsuki
K
K
D003432:Cross-Linking Reagents; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis
D003432:Cross-Linking Reagents; D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin