Ciprofloxacin resistance in methicillin- and gentamicin-resistant Staphylococcus aureus.
A total of 112 Staphylococcus aureus strains resistant to methicillin and gentamicin were collected from 31 centres in 22 countries worldwide. Many strains were multi-resistant. In tests to determine the susceptibility of the organisms to ciprofloxacin 16 strains (14.3%), originating from France, the FRG, Israel and Italy, were shown to be resistant to this agent. To limit ciprofloxacin resistance, a reappraisal is necessary of fluoroquinolone usage against methicillin- and gentamicin-resistant Staphylococcus aureus.
Maple
P
P
Department of Medical Microbiology, Royal Free Hospital School of Medicine, Hampstead, London, UK.
Hamilton-Miller
J
J
Brumfitt
W
W
D002939:Ciprofloxacin / Q000494:pharmacology*; D003030:Coagulase; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
D003030:Coagulase; D005839:Gentamicins; D002939:Ciprofloxacin; D008712:Methicillin