[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis].
The paper presents the general data concerning cytochrome P-448, as well as its participation in the formation of oxygen radicals and active metabolic intermediates, originated during xenobiotics' oxidation. Also, induction of synthesis of cytochrome P-448 (aromatic hydrocarbons hydroxylase), along with the role this phenomenon plays in the initiation of neoplastic process, are discussed.
Lutz
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Sułkowski
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D000082:Acetaminophen / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D006900:Hydroxylation; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009369:Neoplasms / Q000139:chemically induced*; D010634:Phenobarbital / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D011083:Polycyclic Compounds / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism
D003580:Cytochromes; D005609:Free Radicals; D011083:Polycyclic Compounds; D000082:Acetaminophen; D006899:Mixed Function Oxygenases; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2; D010634:Phenobarbital
Bioaktywacja ksenobiotyków przez cytochromy P-448 i ich udział w procesie kancerogenezy.