Growth regulatory proteins from human platelets.
Platelets contain many different growth regulatory proteins. This communication describes two of these factors, platelet-derived growth factor, a major mitogen for connective tissue cells, and platelet-derived endothelial cell growth factor, an endothelial cell mitogen with angiogenic properties in vivo. In addition, the structural and functional properties of the latent, high Mr complex of transforming growth factor-beta 1, a factor that inhibits growth of most cells, is described.
Heldin
C H
CH
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
Miyazono
K
K
Claesson-Welsh
L
L
Westermark
B
B
D001792:Blood Platelets / Q000502:physiology*; D002455:Cell Division; D006801:Humans; D009389:Neovascularization, Pathologic; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000145:classification / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology*
D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; D011505:Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor