Genetic control of susceptibility to mycobacterial infections.
Susceptibility of mice to the establishment of infection after exposure to mycobacteria is controlled by a single, dominant, autosomal gene: the Bcg gene. It is located on the centromeric portion of chromosome 1 within a linkage group that shows structural homology with a conserved region of human chromosome 2. The Bcg gene regulates directly the process of T cell-independent macrophage activation for antimycobacterial function and, indirectly, the magnitude and the quality of specific immune response to mycobacterial antigens.
Skamene
E
E
Montreal General Hospital, McGill University, Quebec, Canada.
D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005802:Genes, MHC Class II; D006801:Humans; D051379:Mice; D009164:Mycobacterium Infections / Q000235:genetics* / Q000276:immunology; D010641:Phenotype; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology