[Effect of fluorine on heart arrhythmias in rats].
The antiarrhythmic activity of fluoride was studied in a model of CaCL2-induced heart arrhythmias in male albino rats. The prolonged intake of sodium fluoride with drinking water (2 mg/l for 1 month) significantly reduced the severity of arrhythmias that was evident as an increase in the latency and a decrease in the frequency and duration of arrhythmias. A less pronounced effect was noted when the concentration of sodium fluoride was increased to 5 mg/l. At larger concentrations (11 mg/l) the fluoride exerted a toxic effect and potentiated the arrhythmogenic action of CACL2. The antiarrhythmic action of fluoride in low concentrations may be associated with the blockade of an inward Ca current.
Karpova
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MN
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D015220:Calcium Channels / Q000187:drug effects; D002122:Calcium Chloride; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005457:Fluoridation; D008297:Male; D051381:Rats; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D015220:Calcium Channels; D013607:Tablets; D012969:Sodium Fluoride; D002122:Calcium Chloride
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