Variations in genome fragments coding for RNA polymerase in human and simian hepatitis A viruses.
The genome of hepatitis A virus (HAV) isolated from spontaneously infected African vervet monkey (Cercopithecus aethiops) has been cloned and partially sequenced. Comparison of genome fragments (1248 and 162 bp) from the 3D (RNA polymerase) region with the corresponding parts of human HAV genomes revealed a high degree of heterogeneity: there were altogether 257 nucleotide changes leading to 44 substitutions in predicted amino acid sequence, i.e. 89% amino acid identity. This divergence is considered to be significantly greater than genomic variations usually found among human HAV strains, where amino acid identity in the 3D region is over 98%.
Balayan
M S
MS
Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, M.M. Shemyakin Institute of Bioorganic Chemistry, Moscow.
Kusov YuYu
Andjaparidze
A G
AG
Tsarev
S A
SA
Sverdlov
E D
ED
Chizhikov
V E
VE
Blinov
V M
VM
Vasilenko
S K
SK
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002521:Cercopithecus / Q000382:microbiology*; D002522:Chlorocebus aethiops / Q000382:microbiology*; D003001:Cloning, Molecular; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D005814:Genes, Viral; D014644:Genetic Variation; D006506:Hepatitis A / Q000382:microbiology / Q000662:veterinary; D006507:Hepatovirus / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000382:microbiology; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D012321:DNA-Directed RNA Polymerases