[IgE-Fc receptor expressions on bronchoalveolar lavage (BAL) cells in a patient with eosinophilic pneumonia accompanied with bronchial asthma--the effect of ketotifen on their expression].
In this study, IgE-Fc receptor expressions on each type of BAL cells (lymphocytes, macrophages and eosinophils) in a patients with eosinophilic pneumonia accompanied by bronchial asthma were examined by indirect immunofluorescent method using monoclonal antibody (H107). BAL cell findings showed marked increases of total BAL cell counts and eosinophils, an increased number of lymphocytes and the presence of basophilic cells. These results match those of our previous report. Furthermore, IgE-Fc receptor expressions on lymphocytes, macrophages and eosinophils were markedly increased as compared to those in the peripheral blood and normal control subjects. These findings suggest that IgE production in the lung plays the main role in the pathogenesis of eosinophilic pneumonia and bronchial asthma. On the other hand, during ketotifen administration, decreases of peripheral blood eosinophilia, of eosinophilia in the sputum and of serum IgE level and an improvement in chest X-ray findings were observed. Furthermore not only normalization of total BAL cell counts but also decreases of IgE-Fc receptor expressions on BAL cells were observed.
Chihara
J
J
Kubo
H
H
Sakurada
R
R
Yamamoto
J
J
Nakano
N
N
Sugihara
R
R
Nakajima
S
S
D000328:Adult; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002452:Cell Count; D004804:Eosinophils / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007665:Ketotifen / Q000627:therapeutic use*; D008214:Lymphocytes / Q000032:analysis; D008264:Macrophages / Q000032:analysis; D008297:Male; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D011961:Receptors, Fc / Q000032:analysis*; D017455:Receptors, IgE
D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E; D007665:Ketotifen