title: Nonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement.
abstract: Peripheral intravenous fluid extravasation is a common occurrence among neonatal intensive care unit patients. Fifteen high-risk neonates, averaging less than 35 weeks' gestation and less than 1,500 g birth weight, with full-thickness extravasation injuries were successfully treated nonoperatively by a topical fibrinolysin/deoxyribonuclease ointment. All wounds healed without delaying hospital discharge, and no significant scar contractures were observed in patients followed up to 16 months after injury.
authors.affiliation: Department of Plastic Surgery, Brown University Affiliated Hospitals and Veterans Administration Medical Center, Providence, RI.
authors.forename: P A
authors.initials: PA
authors.lastname: Falcone
authors.forename: D T
authors.initials: DT
authors.lastname: Barrall
authors.forename: D R
authors.initials: DR
authors.lastname: Jeyarajah
authors.forename: J A
authors.initials: JA
authors.lastname: Grossman
mesh_terms: D000287:Administration, Topical; D003646:Debridement; D003851:Deoxyribonucleases / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D005341:Fibrinolysin / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D009824:Ointments
chemical_list: D004338:Drug Combinations; D009824:Ointments; C021490:deoxyribonuclease, plasmin drug combination; D003851:Deoxyribonucleases; D005341:Fibrinolysin