Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne.
In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months. No changes in sebum excretion rate occurred, but a significant reduction, 15.9 to 10.5%, of free fatty acids of skin surface lipid was detected after 1 month. The follicular Micrococaceae density was significantly reduced after 1 month, and after 2 months there was a significant reduction in follicular Propionibacterium spp density. The final reductions were 2,500 and 44 fold, respectively.
Cunliffe
W J
WJ
Department of Dermatology, Leeds General Infirmary, Yorkshire, England.
Holland
K T
KT
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D000287:Administration, Topical; D000900:Anti-Bacterial Agents; D002986:Clinical Trials as Topic; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008835:Micrococcaceae / Q000187:drug effects; D011424:Propionibacterium / Q000187:drug effects; D012629:Sebum / Q000187:drug effects / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003998:Dicarboxylic Acids; D005230:Fatty Acids, Nonesterified; C010038:azelaic acid