Atrial myoendocrine cells (cardiodilatin/atrial natriuretic polypeptide-containing myocardiocytes) are target cells for estradiol.
Atrial myoendocrine cells of rat were investigated regarding estradiol uptake. It was found that, in addition to their specific endocrine function of producing cardiac polypeptides of the cardiodilatin/atrial natriuretic peptide (CDD/ANP) family, these cells also specifically accumulate radiolabeled estradiol. This co-localization supports the view that steroid hormones play an important role in the regulation of the CDD/ANP gene.
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H
Institut für Anatomie und Zellbiologie, Universität Heidelberg, Federal Republic of Germany.
Forssmann
W G
WG
Stumpf
W E
WE
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001345:Autoradiography; D004958:Estradiol / Q000493:pharmacokinetics*; D005260:Female; D006325:Heart Atria / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D009124:Muscle Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009124:Muscle Proteins; D004958:Estradiol; D009320:Atrial Natriuretic Factor; C040651:cardiodilatin