title: [Study of human and simian hepatitis A virus isolated by an immunoenzyme method using polyclonal and monoclonal antibodies].
abstract: Hepatitis A viruses (HAV) isolated from man and Old World monkeys varied in their interaction with monoclonal antibodies (MCA) in enzyme immunoassay. All human HAV isolates reacted with the MCA under study (HIC19, H7C27, and K3-4C8), whereas the viruses isolated directly from monkeys did not react with H7C27 MCA and some of them also with H1C19 MCA. Simian HAV strains became capable of reacting with H7C27 MCA and H1C19 MCA after adaptation to cell culture. In tests with human and simian immune sera (polyclonal antibody to HAV) a number of human isolates interacted with human serum antibodies much more intensively and with simian serum antibodies.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Karetnyĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Andzhaparidze
authors.forename: T M
authors.initials: TM
authors.lastname: Orlova
authors.forename: M S
authors.initials: MS
authors.lastname: Balaian
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000276:immunology*; D002143:Callitrichinae; D035922:Hepatitis A Antibodies; D035921:Hepatitis A Antigens; D006508:Hepatitis Antibodies / Q000276:immunology; D006507:Hepatovirus / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D035922:Hepatitis A Antibodies; D035921:Hepatitis A Antigens; D006508:Hepatitis Antibodies
vernacular_title: Issledovanie izoliatov virusa gepatita A chelovecheskogo i obez'ian'ego proiskhozhdeniia immunofermentnym metodom s ispol'zovaniem poliklonal'nykh i monoklonal'nykh antitel.