Comparative haemodynamic effects of ketanserin and ritanserin in the proximal and distal upper limb circulations of hypertensive patients.
The effects of ketanserin (40 mg p.o.) on blood pressure and brachial haemodynamics (brachial artery diameter, brachial blood velocity and blood flow) have been compared in a double-blind study with those of ritanserin (10 mg p.o.) and placebo. Haemodynamic parameters were measured before and 1 h after treatment. Patients with mild to moderate essential hypertension participated in this study, 6 each on ketanserin, ritanserin and placebo. Placebo significantly reduced heart rate and did not modify the other parameters. Compared to placebo, ketanserin significantly reduced systolic and diastolic blood pressure, increased brachial blood velocity and flow, and decreased forearm vascular resistance. Compared to placebo, ritanserin slightly decreased blood pressure and slightly increased blood flow, but neither effect was significant. When blood circulation to the hand was excluded, neither ketanserin nor ritanserin modified the proximal arterial resistance or blood flow. It is concluded that the actions of ketanserin and ritanserin essentially occurred in the distal part of the upper limb, and alpha 1-receptor blockade is probably involved.
Chau
N P
NP
Unité de Recherches Biomathématiques et Biostatistiques, INSERM U263, Université de Paris, France.
Pithois-Merli
I
I
Levenson
J
J
Simon
A C
AC
D001132:Arm / Q000098:blood supply*; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects; D004311:Double-Blind Method; D006225:Hand / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007650:Ketanserin / Q000494:pharmacology*; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D016713:Ritanserin; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D010880:Piperidines; D012702:Serotonin Antagonists; D016713:Ritanserin; D007650:Ketanserin