Active oxygen contributes to the major part of chromosomal aberrations in V79 Chinese hamster cells exposed to N-hydroxy-2-naphthylamine.
N-hydroxy-2-naphthylamine (NOH-2NA), an active metabolite of human occupational bladder carcinogens, induced, in V79 Chinese hamster cells, chromosomal aberrations which were suppressed in the presence of catalase and/or superoxide dismutase. The induction of the aberrations was more efficient in a more basic pH in parallel with the generation of hydrogen peroxide from NOH-2NA. The possible role of the oxidation product of NOH-2NA in the induction of the aberrations is discussed.
Ochi
T
T
Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Kaneko
M
M
D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000633:toxicity*; D000818:Animals; D002374:Catalase / Q000494:pharmacology; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D009281:Naphthalenes / Q000633:toxicity*; D010100:Oxygen / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000633:toxicity
D005609:Free Radicals; D009281:Naphthalenes; D013481:Superoxides; D006861:Hydrogen Peroxide; D015081:2-Naphthylamine; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen; C019424:N-hydroxy-2-naphthylamine