Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.
We have sequenced a gene in human cytomegalovirus and a homologous gene in human herpesvirus 6 which could specify a product related to protein kinases. This gene appears to be generic in the herpesvirus family as homologues were found in three other human herpesviruses. The five sequences were aligned and found to be quite divergent. Some of the differences occur at amino acid positions which are functionally important and highly conserved in known protein kinases. Hence these genes may represent a significant departure from known protein kinases in terms of structure and/or function.
Chee
M S
MS
Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K.
Lawrence
G L
GL
Barrell
B G
BG
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D005075:Biological Evolution; D002384:Catalysis; D003587:Cytomegalovirus / Q000201:enzymology / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D006564:Herpesviridae / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D004279:DNA, Viral; D011494:Protein Kinases