title: Antioxidant enzyme activities in heart and skeletal muscle of rats of different ages.
abstract: The activity of antioxidant enzymes was measured in cardiac and skeletal muscle in rats aged either 4, 15, or 27 months. Generally, regardless of age, heart contains a greater content of these enzymes than skeletal muscle. Whereas skeletal muscle showed age-dependent increases in glutathione peroxidase, glutathione reductase, and catalase activities, heart tissue showed increases in only the glutathione peroxidase activity. Neither tissue showed any significant age-dependent change in cytosolic or mitochondrial superoxide dismutase content or in cytochrome oxidase.
authors.affiliation: Biological Research Laboratories, Sigma-Tau S.p.A., Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Vertechy
authors.forename: M B
authors.initials: MB
authors.lastname: Cooper
authors.forename: O
authors.initials: O
authors.lastname: Ghirardi
authors.forename: M T
authors.initials: MT
authors.lastname: Ramacci
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D003576:Electron Transport Complex IV