title: [Trisomy of chromosome 11 in a case of common ALL antigen-positive acute myeloblastic leukemia (FAB-M1)].
abstract: In February 1986, a 68-year-old woman was diagnosed as having acute myeloblastic leukemia (FAB-M1). At the time of diagnosis, 86.0% of the bone marrow cells were myeloblastoid, and 15% of these myeloblastoid cells were positive to myeloperoxidase. Surface marker analysis by flow cytometry disclosed granulocyte-associated antigen (MY7) and also lymphocyte-associated antigen (CALLA) on the leukemic cells. Chromosomal banding studies of bone marrow cells revealed trisomy 11 in 6 of 19 metaphases examined and normal karyotype in the others. Complete remission was attained after intensive combination chemotherapy, and has remained for 38 months. Only 19 patients with trisomy 11-associated acute nonlymphocytic leukemia (ANLL) including the present case have been reported. Morphologic analyses have revealed that the frequency of FAB-M1 is high. However, except for the present case, surface marker findings were apparent in only one M5a patient, in whom monocyte-macrophage-associated antigen was detected. Accordingly, careful surface marker studies will be needed to clarify the frequency of acute mixed lineage leukemia in such patients.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Jubashi
authors.forename: I
authors.initials: I
authors.lastname: Jinnai
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: T
authors.initials: T
authors.lastname: Itoyama
authors.forename: S
authors.initials: S
authors.lastname: Tokunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Moriuchi
authors.forename: N
authors.initials: N
authors.lastname: Sadamori
authors.forename: M
authors.initials: M
authors.lastname: Ichimaru
mesh_terms: D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology; D015260:Neprilysin; D014314:Trisomy
chemical_list: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin