title: Noble PRST-1 Ca prostate adenocarcinoma study on noble rats: preliminary study on new androgen sensitive tumor.
abstract: The Nb rat prostatic adenocarcinoma model has served as an animal model for testing various chemotherapeutic agents. Herein this preliminary report, the tumor Nb PRST-1 Ca was evaluated in 25 animals with testosterone, dihydrotestosterone, orchiectomized and control treatments. Tumor growth curves were determined and show a significant difference on day 13 (T-test) between the control group and treatment groups. Metastases were found in the lungs of all animals and a remarkable rounding of the liver was noted in the androgen treatment groups.
authors.affiliation: Department of Surgery, College of Medicine, Ohio State University Columbus.
authors.forename: G
authors.initials: G
authors.lastname: Wientjes
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Miller
authors.forename: R A
authors.initials: RA
authors.lastname: Badalament
authors.forename: J R
authors.initials: JR
authors.lastname: Drago
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D013196:Dihydrotestosterone / Q000627:therapeutic use*; D008297:Male; D009362:Neoplasm Metastasis; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone