The antitumor effects of IFN- beta against human renal cell carcinoma in athymic nude mice.
IFN-beta was more active than recombinant interferon-alpha (rIFN-alpha) and interferon-gamma (rIFN-gamma) in a human renal cell carcinoma transplanted in nude mice. In 3 out of 5 mice, the tumor completely disappeared and viable tumor cells were not observed at a daily dose of 5 x 10(5) U/mouse. Combination with anti-asialo GM1 antibody did not influence the tumor growth inhibition by IFN-beta. Mononuclear cells around damaged cancer cells were found not to be macrophages. Although the role of mononuclear cells remained unknown, the antitumor activity of IFN-beta seemed to depend on its direct cellular action. IFN-beta may be a useful agent in some renal cell carcinomas.
Shirahama
T
T
Department of Urology, Faculty of Medicine, Kagoshima University, Japan.
Kayajima
T
T
Ohi
Y
Y
D000818:Animals; D000906:Antibodies; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000032:analysis / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011994:Recombinant Proteins; D014183:Transplantation, Heterologous
D000906:Antibodies; D006028:Glycosphingolipids; D007370:Interferon Type I; D011994:Recombinant Proteins; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D016899:Interferon-beta; D007371:Interferon-gamma