Insulin-like growth factor I receptors on erythrocytes in NIDDM.
We examined 125I-insulin-like growth factor I (125I-IGF-I) binding to erythrocytes from 24 normal and 21 non-insulin-dependent diabetic (NIDDM) subjects. 125I-IGF-I binding to human erythrocytes was specifically inhibited by unlabeled IGF-I, and Scatchard analysis indicated a curvilinear plot. There was a significant difference in IGF-I binding between normal and diabetic subjects (7.78 +/- 0.42 vs. 5.80 +/- 0.33%/2.4 x 10(9) cells/ml, P less than 0.001). Among diabetic patients, IGF-I binding to erythrocytes from those with retinopathy and those without retinopathy was comparable. These results suggested that decreased IGF-I binding might be a factor responsible for some pathological features such as delayed wound healing in diabetic patients.
Haruta
T
T
Third Department of Medicine, Shiga University of Medical Science, Japan.
Kobayashi
M
M
Takata
Y
Y
Ishibashi
O
O
Shigeta
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D004912:Erythrocytes / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011956:Receptors, Cell Surface / Q000097:blood*; D017451:Receptors, Somatomedin
D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I