title: Pharmaceutical development of ondansetron injection.
abstract: Ondansetron injection is an aqueous solution containing ondansetron base as the hydrochloride dihydrate. The pH of the injection was selected to achieve good physical and chemical stability. The shelf life is 3 years when stored below 30 degrees C, protected from light. Ondansetron injection may be diluted for administration by slow intravenous injection or infusion and is compatible with several intravenous infusion fluids. In addition, specific concentrations of cisplatin, 5-fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide and doxorubicin are compatible when administered via a giving set delivering ondansetron by infusion.
authors.affiliation: Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
authors.forename: R E
authors.initials: RE
authors.lastname: Leak
authors.forename: J D
authors.initials: JD
authors.lastname: Woodford
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004347:Drug Interactions; D004355:Drug Stability; D007093:Imidazoles / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D017294:Ondansetron; D012702:Serotonin Antagonists; D012996:Solutions
chemical_list: D000932:Antiemetics; D007093:Imidazoles; D012702:Serotonin Antagonists; D012996:Solutions; D017294:Ondansetron