Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15.
The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. Only acetylgrandifloric acid (ent-kaur-16-en-15 alpha-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-en-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations greater than or equal to 250 micrograms/ml, the 15 alpha epimer being the most active.
Davino
S C
SC
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Giesbrecht
A M
AM
Roque
N F
NF
D001409:Bacillus cereus / Q000187:drug effects; D001938:Brazil; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
D004224:Diterpenes; D010936:Plant Extracts; C047875:kaur-16-en-15-ol