[Effects of eledoisin on water intake induced by subcutaneous injection of hypertonic NaCl in the rat].
Intracerebroventricular administration of eledoisin, the tachykinin peptide of the salivary glands of Eledone Moschata, exerts a potent and long-lasting inhibition of water intake induced by the subcutaneous administration of hypertonic NaCl in the rat. The inhibitory effect is statistically significant up to 6 hr following eledoisin treatment, while the 24 hr water intake in control and treated rats is essentially identical. The results of the present study demonstrate that the long-lasting effect is not due to increased renal excretion of the osmotic load, nor, likely, to larger production of metabolic water. Probably, eledoisin exerts an inhibitory effect of such a long duration by means of central actions which last well beyond its half-life, or, alternatively, by promoting an increased excretion of the osmotic load through elimination routes different from the kidney.
Perfumi
M C
MC
Istituto di Farmacologia, Facoltà di Farmacia, Università di Camerino, Italy.
Polidori
C
C
Caraffa
E
E
Cucculelli
M
M
Fede
M
M
Fiorelli
A
A
D000818:Animals; D004231:Diuresis; D004327:Drinking Behavior / Q000187:drug effects*; D004600:Eledoisin / Q000494:pharmacology*; D006982:Hypertonic Solutions; D007279:Injections, Subcutaneous; D008297:Male; D009995:Osmosis; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D006982:Hypertonic Solutions; D012965:Sodium Chloride; D004600:Eledoisin
Effetto della eledoisina sulla assunzione di acqua indotta da iniezione sottocutanea di NaCl ipertonico nel ratto.