8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine.
Vomiting was suppressed in cats pretreated with 8-OH-DPAT and then challenged with an emetic stimulus; motion, xylazine or cisplatin. The antiemetic effect is likely due to stimulation of postsynaptic serotonin-1A receptors. The most parsimonious explanation is that it acts at a convergent structure, presumably at or near the vomiting center. If so, 8-OH-DPAT may block emesis elicited by virtually any other stimulus. A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis. These results do not support the possibility that the antiemetic effects of 8-OH-DPAT were the result of anxiolytic activity.
Lucot
J B
JB
Department of Pharmacology and Toxicology, Wright State University, Dayton, OH.
Crampton
G H
GH
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D002415:Cats; D002945:Cisplatin / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008140:Lorazepam / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009041:Motion Sickness / Q000150:complications* / Q000517:prevention & control; D009281:Naphthalenes / Q000627:therapeutic use*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology / Q000627:therapeutic use*; D013843:Thiazines / Q000009:adverse effects*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*; D014991:Xylazine / Q000009:adverse effects*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D013843:Thiazines; D014991:Xylazine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D008140:Lorazepam; D002945:Cisplatin