title: [In vitro effect of cefixime against Haemophilus influenzae].
abstract: Cefixime activity has been determined against Haemophilus influenzae strains producing or not beta-lactamase, or resistant to ampicillin by non-enzymatic mechanism. All strains are inhibited by a concentration of 1 mg/l of cefixime independently of beta-lactamase secretion. Ampicillin-resistant non beta-lactamase producing strains are inhibited by concentrations of 0.12 - 1 mg/l. MIC50 and MIC90 were, respectively, 0.06 and 0.12 mg/l for ampicillin-susceptible strains and 0.12 and 0.12 mg/l for ampicillin-resistant strains. The activity of cefixime against Haemophilus influenzae was superior to that of other orally administered antibiotics tested in this study: amoxicillin, amoxicillin-clavulanic acid, cefaclor and cefuroxime.
authors.affiliation: Laboratoire de Bactériologie, CHU Purpan, Toulouse.
authors.forename: H
authors.initials: H
authors.lastname: Dabernat
authors.forename: C
authors.initials: C
authors.lastname: Delmas
mesh_terms: D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D020682:Cefixime; D001618:beta-Lactamases; D002439:Cefotaxime
vernacular_title: Activité in vitro du céfixime sur Haemophilus influenzae.