The immunoglobulin class, the subclass and the ratio of kappa:lambda light chain of autoantibodies to human insulin in insulin autoimmune syndrome.
The immunoglobulin class, subclass and the k:lambda light chain ratio of insulin autoantibodies were determined in the sera of twenty-four patients with insulin autoimmune syndrome. All sera proved to be of the IgG immunoglobulin class but exhibited various IgG1:IgG2:IgG3:IgG4 ratios. The ratio of k:lambda light chain ranged from 1:0.13 to 1:0.75 with the exceptions of two sera that were characterized as IgG1(k) and IgG1(lambda).
Uchigata
Y
Y
Diabetes Center, Tokyo Women's Medical College, Japan.
Eguchi
Y
Y
Takayama-Hasumi
S
S
Hirata
Y
Y
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000145:classification*; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007330:Insulin Antibodies / Q000097:blood / Q000145:classification*; D008297:Male; D008875:Middle Aged; D013577:Syndrome
D001323:Autoantibodies; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007330:Insulin Antibodies