Clinical manifestations of human parvovirus B19 in adults.
Human parvovirus B19 has been associated with various clinical effects in a number of uncontrolled reports. To define the usual manifestations of B19 infection in adults and the factors that influence them we present a clinicoepidemiological study of an outbreak of B19 infection centered on a junior school. Four hundred fifty-three of 475 adults in this community were interviewed and blood was obtained for serological diagnosis. Fifty-four cases of recent infection were identified and were HLA typed. Fourteen of the cases were asymptomatic; 32 had an influenzalike illness; 23 a rash; and 26 an acute-onset polyarthropathy that was more common in women and lasted for up to 7 months. HLA-A, -B, and -C antigen frequencies were similar to a local control population and showed no association with symptoms except that HLA-DR1 was absent in those with persistent arthropathy.
Woolf
A D
AD
Department of Rheumatology, Bristol Royal Infirmary, England.
Campion
G V
GV
Chishick
A
A
Wise
S
S
Cohen
B J
BJ
Klouda
P T
PT
Caul
O
O
Dieppe
P A
PA
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D004196:Disease Outbreaks; D004739:England; D004890:Erythema / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007592:Joint Diseases / Q000209:etiology; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D012698:Serologic Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M