[The effect of fractionated exposure to unequal concentrations of chemical mutagens].
The effect of unequally fractionated concentrations of dipin and thiophosphamid on chromosomes of human lymphocytes was investigated at Go phase. There were used five low concentrations of mutagens 2, 0.2, 2.10(-2), 2.10(-3), 2.10(-4) mcg/ml and one high concentration 20 mcg/ml by which cells have been treated. Decrease of chromosome breaks and exchanges were observed, but the level of the aberration cell was stable. The "protective" levels for dipin were in concentrations of 0.2, 2.10(-2), 2.10(-3) mcg/ml. Only one "protective" concentration was 2.10(-2) mcg/ml.
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D001388:Aziridines / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009153:Mutagens / Q000633:toxicity*; D013852:Thiotepa / Q000633:toxicity
D001388:Aziridines; D009153:Mutagens; D013852:Thiotepa; C007526:dipin
Effekt fraktsionirovannogo vozdeĭstviia neravnymi kontsentratsiiami khimicheskikh mutagenov.