[Clinical significance of cell kinetics in lung cancer].
A series of 24 lung cancer cases was studied: 12 epidermoid carcinomas, 9 adenocarcinomas, 2 giant-cell carcinomas and 1 carcinoid. The patients were staged on the basis of the TNM classification system as 9 stage I, 5 stage II, 9 stage III and 1 stage IV. Using fresh tumour cell samples 2 cell cultures were prepared for each patient: one to identify the percentage of S phase cells (Labelling Index) using the tritiated thymidine method and one for cytogenetic analysis. A gentic map was obtained in 6 cases and revealed no specific numerical or structural alterations. The Labelling Index (L.I.) was calculated for all patients and compared with all TNM parameters. This revealed a certain connection between L.I. and parameters T, SN and G but no link with parameters.
Grignani
F
F
Instituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Milano.
Varoli
F
F
Lavezzi
A M
AM
Scalambra
S M
SM
Vergani
C
C
Maturri
L
L
Roviaro
G C
GC
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002453:Cell Cycle; D005500:Follow-Up Studies; D006801:Humans; D007399:Interphase; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
Significato clinico della cinetica cellulare nel cancro del polmone.