title: Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosides.
abstract: In a case of motor-dominant neuropathy and IgM paraproteinemia, the binding specificity of the serum IgM M-protein was characterized by enzyme-linked immunosorbent assay (ELISA). The serum IgM M-protein bound preferentially to ganglioside GM1 with slight cross-reactivity to both GM2 and GD1b. The binding specificity of the antibody and clinicopathological features are discussed.
authors.affiliation: Department of Neurology, School of Medicine, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kusunoki
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Maemura
authors.forename: T
authors.initials: T
authors.lastname: Mannen
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000150:complications* / Q000378:metabolism; D010265:Paraproteinemias / Q000150:complications* / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000378:metabolism
chemical_list: D005732:Gangliosides; D007075:Immunoglobulin M