Diamine oxidase (DAO) activity increase in sera of tumor patients: an unreliable marker.
Circulating diamine oxidase (DAO) (EC 1.4.3.6) activity was determined in the sera of patients with different malignant tumors. The increase in this activity only partially reflected tumor activity so it is presumably unreliable as a diagnostic marker. The increase in activity may be linked to the tumor location: the lung and intestine are rich in DAO so the rise cannot be considered a characteristic consequence of the tumor's activity. Besides, increases in DAO activity have also been observed in non-neoplastic diseases.
Romano
M
M
Department of Biochemistry, Tumor Institute, Napoli, Italy.
Pasquinelli
R
R
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*
D014408:Biomarkers, Tumor; D006631:Amine Oxidase (Copper-Containing)