Interferon efficiency in the treatment of herpetic dermatites. II. Comparison between human leukocyte interferon (Ginterferon) and a recombinant interferon (Roferon).
The comparative efficiency of a recombinant interferon-Roferon (R-IFN) and a human, naturally synthetized interferon-Ginterferon (G-IFN), applied as ointments in the treatment of herpetic dermatites, was studied in a blind trial. It was found that R-IFN in doses of 20,000 IU/g has practically similar results as G-IFN in doses of 10,000 IU/g therefore half the dose of the former product. Thus both preparations reduced significantly the mean duration of a herpetic dermatitis attack and both proved more efficient on smaller lesions (less than 2 sq.cm) than on larger ones (over 2 sq.cm). Likewise with both preparations the reduction of the healing period was more marked when administered in the first 2-3 days after onset. It was also found that the arrest of new vesicle appearance after two days of treatment is a reliable clinical criterion for the estimation of IFN capacity to block effectively viral multiplication in the host's epithelial cells. Finally the efficacy of both R-IFN and G-IFN proved similar whatever the localization of disease (oral or genital) or in their capacity to prevent relapses or the appearance of bacterial complications.
Ghyka
G
G
V Babes Institute, Bucharest, Romania.
Alecu
M
M
Călugăru
A
A
Coman
G
G
D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006558:Herpes Genitalis; D006560:Herpes Labialis; D006561:Herpes Simplex / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins; D012874:Skin Diseases, Infectious / Q000628:therapy*; D013997:Time Factors
D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma