title: Carbohydrates as recognition molecules in infection and immunity.
abstract: Consideration of host-parasite interactions encompasses a wide range of phenomena from adhesion to epithelial surfaces to interactions with cells of the immune system. This review focuses on the role of carbohydrates as recognition molecules in these complex interactions. The abundant glycoproteins and glycolipids of cell surfaces of both prokaryotic and eukaryotic cells have the ability to exist in a variety of spatial configurations through alpha- and beta-linkages and the formation of branched structures. This ability carries with it the opportunity of acting as informational molecules greater than that possible for proteins or nucleic acids. The blood group substances are probably the best characterized of these carbohydrate containing molecules. Whilst at present a detailed understanding of the importance of these molecules in host-parasite interaction is lacking, the material covered in this discussion emphasizes the way in which carbohydrate based recognition has been shown to be involved and may provide the basis for further understanding.
authors.affiliation: Department of Bacteriology, University of Edinburgh Medical School, U.K.
authors.forename: D M
authors.initials: DM
authors.lastname: Weir
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D001789:Blood Group Antigens / Q000276:immunology; D002241:Carbohydrates / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology; D006801:Humans; D007239:Infections / Q000097:blood / Q000276:immunology*; D037102:Lectins / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008262:Macrophage Activation; D011991:Receptors, Virus / Q000276:immunology; D014780:Viruses / Q000276:immunology
chemical_list: D001789:Blood Group Antigens; D002241:Carbohydrates; D015815:Cell Adhesion Molecules; D037102:Lectins; D011991:Receptors, Virus