Immunoenzyme techniques in dermatopathology.
The advantages and disadvantages of the immunofluorescence and immunoperoxidase techniques and an introductory description of the major variations of the basic immunoperoxidase method are discussed. The ability to identify intermediate filaments, T and B lymphocyte cell markers, S-100 proteins, myelin basic protein, and carcinoembryonic antigen in tissue sections can assist the dermatopathologist in classifying undifferentiated or histologically similar-appearing tumors. A systematic approach to the diagnosis of a majority of these tumors with the use of immunoenzyme staining is provided.
Doherty
M J
MJ
Department of Dermatology, Louisiana State University Medical Center, New Orleans 70112.
Russo
G G
GG
Jolly
H W
HW
Stewart
K R
KR
D000943:Antigens, Differentiation / Q000032:analysis; D001402:B-Lymphocytes / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003599:Cytoskeleton / Q000032:analysis; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D017493:Leukocyte Common Antigens; D009185:Myelin Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000175:diagnosis*; D013601:T-Lymphocytes / Q000032:analysis
D000943:Antigens, Differentiation; D002272:Carcinoembryonic Antigen; D006649:Histocompatibility Antigens; D009185:Myelin Proteins; D009418:S100 Proteins; D017493:Leukocyte Common Antigens