title: Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers.
abstract: The ERBA beta gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBA beta locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBA beta. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DNF15S2 (band 3p21) but not at ERBA beta, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBA beta and is almost certainly not the latter.
authors.affiliation: Institut du Cancer de Montréal, Hôpital Notre-Dame, Québec, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Leduc
authors.forename: H
authors.initials: H
authors.lastname: Brauch
authors.forename: C
authors.initials: C
authors.lastname: Hajj
authors.forename: A
authors.initials: A
authors.lastname: Dobrovic
authors.forename: F
authors.initials: F
authors.lastname: Kaye
authors.forename: A
authors.initials: A
authors.lastname: Gazdar
authors.forename: J W
authors.initials: JW
authors.lastname: Harbour
authors.forename: O S
authors.initials: OS
authors.lastname: Pettengill
authors.forename: G D
authors.initials: GD
authors.lastname: Sorenson
authors.forename: A
authors.initials: A
authors.lastname: van den Berg
mesh_terms: D015139:Blotting, Southern; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D015342:DNA Probes; D006579:Heterozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011988:Receptors, Thyroid Hormone / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D015342:DNA Probes; D011988:Receptors, Thyroid Hormone