[Comparison of the teratogenic properties manifested in BALB c mice, by diphenylhydantoin and deuterated diphenylhydantoin].
The aim of this study was to investigate the role of an arene oxide pathway in the teratogenicity displayed by DPH, a highly effective antiepileptic agent. This approach was carried out by comparing the teratogene potential of DPH and of p2-H-DPH administrated at days 8, 9 and 12 of gestation. The present findings support the hypothesis that substitution of protium by deuterium at the para position of one of the phenyl rings, which favours an arene oxide pathway, causes an increase in some to the teratogenic effects of DPH.
Lambotte-Vandepaer
M
M
Unité de Tératogenèse et Mutagenèse, Bruxelles.
Brams
A
A
Crutzen-Fayt
M C
MC
Duverger-Van Bogaert
M
M
Dumont
P
P
Léonard
A
A
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D003903:Deuterium / Q000009:adverse effects*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; D010672:Phenytoin; D003903:Deuterium
Comparaison des propriétés tératogènes manifestées, chez les souris de race BALB-c, par la diphénylhydantoïne et la diphénylhydantoïne deutérée.