title: Simultaneous two-probe laser Doppler velocimetric assessment of topically applied drugs in rats.
abstract: A simple, noninvasive method for the determination of cutaneous blood flow in anesthetized rats is presented. Simultaneous two-probe laser doppler velocimetry is shown to be a useful preclinical tool for the assessment of topically applied drugs.
authors.affiliation: Department of Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey.
authors.forename: G M
authors.initials: GM
authors.lastname: Hirkaler
authors.forename: L B
authors.initials: LB
authors.lastname: Rosenberger
mesh_terms: D000287:Administration, Topical; D000818:Animals; D008297:Male; D008914:Minoxidil / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D012867:Skin / Q000098:blood supply*
chemical_list: D008914:Minoxidil