Effect of a uridine 5'-diphosphate glucose analogue on herpes simplex keratitis in rabbits and vaginal infection in guinea pigs.
A uridine 5'-diphosphate glucose analogue, active in vitro against herpes simplex type 1 and 2 viruses, was assayed in rabbit infected corneas with the above viruses. The infected eyes were treated by drug instillation thrice daily and evaluation of ocular lesion was performed by slit-lamp biomicroscopy. The compound [[[5'-(2'',3'',4'',6''-tetra-O-benzoyl-alpha-D-glucopyranosyl)oxy] carbonyl]amino)sulfonyl]uridine shows a moderate antiviral activity, resulting in a reduction in the severity of clinical illness during acute infection. Vaginal infection of guinea pigs with herpes simplex type 2 virus was treated topically by instillation twice daily with the compound. The effect on clinical evolution was related to viral shedding from the genital tract, and a moderate reduction of both parameters in respect to the infected untreated controls was observed.
Vilas
P
P
Centro de Investigaciones Biológicas, Madrid, Spain.
Perez
C
C
Perez
S
S
Villalon
D G
DG
Gancedo
A G
AG
Gil-Fernandez
C
C
Garcia-López
M T
MT
de las Heras
F G
FG
D000818:Animals; D003315:Cornea / Q000382:microbiology; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000382:microbiology; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects; D013997:Time Factors; D014532:Uridine Diphosphate Glucose / Q000031:analogs & derivatives / Q000494:pharmacology*; D014539:Uridine Diphosphate Sugars / Q000494:pharmacology*
D014539:Uridine Diphosphate Sugars; D014532:Uridine Diphosphate Glucose