title: Thyroid antigen-mediated glomerulonephritis in Graves' disease.
abstract: We describe a patient with Graves' disease in whom marked proteinuria, microhematuria and hypoalbuminemia were associated. Renal biopsy demonstrated electrondense deposits in the capillary basement membrane, a finding consistent with immune complex glomerulonephritis. Indirect immunofluorescent examination with rabbit antihuman thyroglobulin indicated that these electron-dense deposits were thyroid antigen-mediated immune complexes.
authors.affiliation: Surugadai Nihon University Hospital, Department of Cardiology, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: R
authors.initials: R
authors.lastname: Kan
authors.forename: A
authors.initials: A
authors.lastname: Osaku
authors.forename: S
authors.initials: S
authors.lastname: Koyama
authors.forename: S
authors.initials: S
authors.lastname: Shibayama
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Narumiya
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Kojima
mesh_terms: D000936:Antigen-Antibody Complex / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D015433:Glomerulonephritis, Membranous / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D001324:Autoantigens; D013954:Thyroglobulin