title: The effect of lactate-buffered solutions on the acid-base status of patients with renal failure.
abstract: We investigated the effect of an exogenous lactate load given during intermittent machine haemofiltration to three groups of patients with renal failure: those with dialysis-dependent end-stage renal failure (6 patients) and those with either acute renal (8 patients) and/or acute hepatorenal failure (6 patients). As expected, the hepatorenal group exhibited the greatest degree of hyperlactataemia, and this was associated with the development of a metabolic acidosis. There were correlations between the maximum blood lactate measured during treatment and the increase in arterial hydrogen ion concentration (r = 0.76, P less than 0.001), and between the decrease in serum bicarbonate (r = 0.89, P less than 0.001) and the mean arterial blood pressure prior to treatment (r = -0.57, P = 0.003). This suggests that hyperlactataemia is not as benign as previously thought and that lactate-buffered fluids should be used with care in patients with hepatorenal failure and cardiovascular instability.
authors.affiliation: Department of Renal Medicine, St James's University Hospital, Leeds, UK.
authors.forename: A
authors.initials: A
authors.lastname: Davenport
authors.forename: E J
authors.initials: EJ
authors.lastname: Will
authors.forename: A M
authors.initials: AM
authors.lastname: Davison
mesh_terms: D000137:Acid-Base Imbalance / Q000139:chemically induced*; D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D000368:Aged; D002021:Buffers; D005260:Female; D006440:Hemofiltration / Q000009:adverse effects; D006530:Hepatorenal Syndrome / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D007773:Lactates / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D002021:Buffers; D007773:Lactates