The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells.
CD3+ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.
Thiele
D L
DL
Lipsky
P E
PE
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D017252:CD3 Complex; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D017252:CD3 Complex; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell