Ultrastructure of atrial and ventricular myocytes of newborn rats: evidence for the existence of specific atrial granule-like organelles in the ventricle.
The present study examined the ultrastructure of atrial and ventricular myocytes from the heart of newborn rats. It was found that, despite former reports stating that ventricular myocytes in adults do not contain cytoplasmic granules, specific atrial granule-like organelles are present in the ventricles of rats at birth. The presence of these granules together with the relatively underdeveloped contractile apparatus and extensive Golgi complex suggests that the ventricular, like the atrial, myocytes may have an endocrine function before or at birth. Further study is required to determine whether these ventricular cytoplasmic granules contain the same atrial natriuretic peptide species known to be present in the atrial specific granules.
Venance
S L
SL
Department of Anatomy, Queen's University, Kingston, Ontario, Canada.
Pang
S C
SC
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000502:physiology; D002450:Cell Communication; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005260:Female; D006056:Golgi Apparatus / Q000502:physiology / Q000648:ultrastructure; D006325:Heart Atria / Q000648:ultrastructure*; D006352:Heart Ventricles / Q000648:ultrastructure*; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure*; D011247:Pregnancy; D051381:Rats; D011921:Rats, Inbred WKY
D009320:Atrial Natriuretic Factor