The synthesis of Navelbine prototype of a new series of vinblastine derivatives.
Potier
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Institut de Chimie des Substances Naturelles du CNRS, Gif-sur-Yvette, France.
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D011522:Protons; D008941:Spindle Apparatus / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D014748:Vinca Alkaloids; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D011522:Protons; D014404:Tubulin; D014748:Vinca Alkaloids; C009667:vindoline; D014747:Vinblastine; D000077235:Vinorelbine; C017836:catharanthine