Relative importance of the dopaminergic system in haloperidol-catalepsy and the anticataleptic effect of antidepressants and methamphetamine in rats.
The mechanisms involved in haloperidol (HPD)-catalepsy in rat and the effect of antidepressants and methamphetamine (MA) were studied. HPD-catalepsy, as measured by high bar test, lasted for 6-8 min. MA, imipramine (IMP), nomifensine (NOM) and mianserin (MIAN) reduced the duration of catalepsy on IP injection. Electrolytic lesion of the caudate-putamen (CP) and nucleus accumbens (ACC) extensively reduced HPD-catalepsy. Microinjection of MA and NOM into ACC had a similar effect. In the medial amygdala and CP, only MA displayed anticataleptic activity. Zimelidine did not reduce the duration of catalepsy. These results suggest that dopaminergic systems play a key role in mediating HPD-catalepsy and the anticataleptic activity of MA and NOM.
Al-Khatib
I M
IM
Department of Pharmacology, College of Medicine, University of Salahaddin, Arbil, Iraq.
Fujiwara
M
M
Ueki
S
S
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008803:Mianserin / Q000494:pharmacology; D008845:Microinjections; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015031:Zimeldine / Q000494:pharmacology
D000928:Antidepressive Agents; D009627:Nomifensine; D008803:Mianserin; D015031:Zimeldine; D008694:Methamphetamine; D006220:Haloperidol; D007099:Imipramine; D004298:Dopamine