[A case of pulmonary sarcoidosis with CD8 positive cell dominant alveolitis].
A 55-year-old woman was admitted for examination of bilateral hilar lymphadenopathy. Serum angiotensin converting enzyme was not elevated, but gallium-scan revealed an increased uptake in both lung hilus. The percentage of lymphocytes in the bronchoalveolar lavage fluid (BALF) was elevated (28.9%), and the proportion of OKIa1 positive cells was also elevated (50.5%). However, the ratio of cluster differentiation (CD) 4/8 was inverted at 0.5. Microscopic examination of the mediastinal lymph nodes revealed epithelioid cell granulomas without ceasation, and a diagnosis of sarcoidosis was made. Immunohistochemical examination of the lymph nodes showed predominancy of CD8 positive cells. Patients with pulmonary sarcoidosis having a low CD4/8 ratio in BALF are extremely rare in the early stage of sarcoidosis. The inverted CD4/8 ratio was of interest in regard to the pathogenesis of sarcoidosis.
Haneda
H
H
Yamaguchi
E
E
Okazaki
N
N
Abe
S
S
Kawakami
Y
Y
Nojima
T
T
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology / Q000473:pathology; D016827:CD8 Antigens; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000473:pathology; D012507:Sarcoidosis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens