New developments in the pathogenesis of pulmonary hypertension in the newborn and child.
We have identified several features which appear to play a key role in the pathogenesis of pulmonary vascular disease. Future work will involve exploring the regulation of elastase and elastin synthesis, control of smooth muscle proliferation and production of extracellular matrix. Application of cellular and molecular techniques in vascular research should ultimately lead to new and improved therapeutic approaches.
Rabinovitch
M
M
D000818:Animals; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology / Q000648:ultrastructure; D010196:Pancreatic Elastase / Q000378:metabolism; D011651:Pulmonary Artery / Q000503:physiopathology / Q000648:ultrastructure
D010196:Pancreatic Elastase