Effect of tamoxifen on the activity of enzymes of testicular steroidogenesis.
Testicular homogenates of tamoxifen-treated rats were incubated with labeled steroid precursors (progesterone, 17 alpha-hydroxyprogesterone, dehydroepiandrosterone, androstenedione or testosterone) in order to study the effect of tamoxifen on testicular steroidogenesis. The results indicate that a 9 day treatment with a daily dose of 1 mg tamoxifen produces a reduction of the synthesis of testosterone. Inhibition of the 17 alpha-hydroxylase and C17,20-desmolase enzyme systems was observed together with an increased 20 alpha-hydroxysteroid dehydrogenase activity.
Vanderstichele
H
H
Laboratory of Normal and Pathological Physiology, University of Ghent, Belgium.
Eechaute
W
W
Lacroix
E
E
Leusen
I
I
D015089:20-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008190:Lyases / Q000037:antagonists & inhibitors; D008297:Male; D009929:Organ Size; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors; D013629:Tamoxifen / Q000494:pharmacology*; D013735:Testicular Hormones / Q000096:biosynthesis*; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood
D013735:Testicular Hormones; D013629:Tamoxifen; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015089:20-Hydroxysteroid Dehydrogenases; D013254:Steroid 17-alpha-Hydroxylase; D008190:Lyases