[Effects of various caloric intakes on nitrogen metabolism of the body, the muscles and the viscera during total parenteral nutrition with aminoacidic solution enriched with branched-chain amino acids].
Nitrogen metabolism was studied in ten injured/septic patients by means of a two compartment model, differentiating muscle from non muscle (central) tissue. During fasting muscle tissue loses a consistent amount of aminoacids which is retained in part by central tissue, giving rise to a positive nitrogen balance, whilst three methyl histidine and body nitrogen output are elevated. Total parenteral nutrition (glucose 15 kcal kg-1 day-1, nitrogen 0.30 g kg-1 die-1) improved body nitrogen balance and three methyl histidine excretion, but did not affect significantly either muscle or central nitrogen balance. Increasing caloric support to 30 kcal kg-1 day-1 did not showed any further effect on body nitrogen balance and three methyl histidine, while it improved significantly vs basal muscle nitrogen balance, but did not affect central nitrogen balance.
Iapichino
G
G
Colombo
A
A
Leoni
L
L
Marengo
M
M
Quarenghi
E
E
Radrizzani
D
D
Ravagnan
R
R
Rigoli
A
A
Veschi
G
G
D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D002149:Energy Intake; D005215:Fasting; D006801:Humans; D009132:Muscles / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D010289:Parenteral Nutrition, Total; D012996:Solutions
D000597:Amino Acids, Branched-Chain; D012996:Solutions; D009584:Nitrogen
Effetto del diverso apporto calorico sul metabolismo azotato corporeo, muscolare e viscerale durante NPT con soluzione aminoacidica arricchita in BCAA.