An explanation of the stability of the incidence of inborn defects.
We propose a mathematical model for the malformation incidence in a population. The model is based on the assumption that malformations occur in a narrow range of embryotoxic doses for a given toxin and that this range varies in the population. Using this assumption, we exhibit malformation incidence curves which are in qualitative agreement with experimental data.
Kůrka
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P
Institute of Physiology, Czechoslovak Academy of Sciences, Praha.
Jelínek
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R
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D000013:Congenital Abnormalities / Q000453:epidemiology*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006801:Humans; D008954:Models, Biological; D011247:Pregnancy; D012984:Software; D013723:Teratogens / Q000633:toxicity*
D013723:Teratogens