Modulation of 7,12-dimethylbenz[a]anthracene-induced transmammary carcinogenesis by disulfiram and butylated hydroxyanisole in mice.
The individual as well as combined chemopreventive actions of disulfiram (DSF) and butylated hydroxyanisole (BHA) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced transmammary carcinogenesis in mice were examined. When nursing mothers receiving normal diet were treated with DMBA (1 mg/mouse) on days 6, 8 and 10 postpartum, the tumor incidence in their 50-week-old F1 progeny was 44.1%. When nursing mothers receiving 0.75% BHA diet, 0.5% DSF diet and 0.75% BHA + 0.5% DSF diet were similarly treated with DMBA, the tumor incidences in their 50-week-old F1 progeny were 14.7% (P less than 0.05), 12.5% (P less than 0.05) and 5.8% (P less than 0.01), respectively. It is concluded that diets containing BHA (0.75%) and DSF (0.5%), singly or in combination, can inhibit transmammary carcinogenesis in Swiss albino mice.
Rao
A R
AR
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Hussain
S P
SP
Jannu
L
L
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002083:Butylated Hydroxyanisole / Q000008:administration & dosage / Q000494:pharmacology*; D004221:Disulfiram / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D011247:Pregnancy
D002083:Butylated Hydroxyanisole; D015127:9,10-Dimethyl-1,2-benzanthracene; D004221:Disulfiram