[Tumor markers used in oncology].
The most useful markers, include human chorionic gonadotropin (hCG), alpha-feto protein (AFP), and carcinoembryonic antigen (CEA). The major utility of those would be in monitoring patients with choriocarcinoma, the germ cell tumors, and gastrointestinal neoplasm. Tumors Markers have not been so successful in the early detection of neoplasm in the general population. Possible explanation will be the lack of specificity for tumors as opposed to normal tissue. Monoclonal antibodies to human tumors cell can be prepared using hybridization techniques. These antibodies are homogenoous, recognize specific antigenic determinants with high affinities, and can be mass produced. Monoclonal antibodies detect qualitative and quantitative differences in the antigenic composition of normal and malignant cells. Have important clinical application in the detection and early diagnosis of cancer, in accurate tumor staging, and in therapy.
Arce Vela
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Universidad Nacional Federico Villareal, Lima, Peru.
D014408:Biomarkers, Tumor / Q000032:analysis; D008495:Medical Oncology / Q000379:methods*
D014408:Biomarkers, Tumor
Marcadores tumorales empleados en oncología.