Surface markers on human activated T lymphocytes. I. Fc receptors for IgG and IgM.
Expression of Fc gamma and Fc mu receptors on human peripheral blood T lymphocytes of two subsets with high (E early rosette forming presumably in vivo activated cells, TEe) and low affinity of E receptors (E late rosette forming presumable resting cells, TEl) was investigated. Different distribution pattern of T gamma and T mu cells in the both examined T cell subsets was found. Thus TEe and TEl subsets have been partially enriched in T mu and T gamma cells, respectively. Furthermore, the results obtained in the PHA-stimulated system have shown that Fc mu receptors do not function as the markers of T cell activation. However, in opposition to this finding Fc gamma receptors may be the early activation markers but only of T cells originally bearing high-affinity E receptors.
Kontny
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Department of Pathophysiology, Institute of Rheumatology, Warsaw.
D000943:Antigens, Differentiation; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011961:Receptors, Fc; D017452:Receptors, IgG; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010835:Phytohemagglutinins; D011961:Receptors, Fc; D017452:Receptors, IgG; C035311:immunoglobulin M receptor