title: Circulatory depression with high peep in the surfactant-deficient rabbit.
abstract: Surfactant depletion was induced by lung lavage in 10 rabbits. Ascending aortic blood flow was measured at normocapnia at 0, 5 and 10 cm H2O PEEP before and after lavage. Aortic blood flow was reduced by PEEP, by a maximum of 24% before lavage and 60% after lavage. It was concluded that, although adequate arterial oxygenation can be maintained with 10 cm H2O PEEP in surfactant-depleted rabbit's lungs, the circulatory impairment may result in inadequate oxygen delivery.
authors.affiliation: Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: A
authors.initials: A
authors.lastname: Holdcroft
authors.forename: S
authors.initials: S
authors.lastname: Sapsed-Byrne
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011663:Pulmonary Surfactants / Q000172:deficiency*; D011817:Rabbits; D012039:Regional Blood Flow; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000628:therapy
chemical_list: D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; D010100:Oxygen