Characterization of rearranged Y chromosomes in human testicular tumor cell lines.
Cytogenetic analysis of four cell lines established from two different human testicular tumors revealed rearranged or missing Y chromosomes. Southern blot analysis and in situ hybridization with different Y-derived human DNA sequences revealed the existence of Y chromosomal material even in a line without a cytogenetically visible Y chromosome and clarified the composition of Y marker chromosomes.
Arnemann
J
J
Institut für Humangenetik, Universitätskliniken, Göttingen, West Germany.
Gradl
G
G
Casper
J
J
Schmoll
H J
HJ
Schmidtke
J
J
Fonatsch
C
C
D001483:Base Sequence; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013736:Testicular Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured; D014998:Y Chromosome
D004273:DNA, Neoplasm