Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.
The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.
Cugini
P
P
I Patologia Medica, Università di Roma La Sapienza, Italia.
Lucia
P
P
Letizia
C
C
Murano
G
G
Scavo
D
D
Giganti
G
G
Calogero
A
A
Verna
R
R
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D002940:Circadian Rhythm; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology / Q000652:urine; D008297:Male; D011187:Posture; D011188:Potassium / Q000652:urine; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D000450:Aldosterone; D012964:Sodium; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium