An evaluation of the biocompatibility of a glass ionomer-silver cement in rat connective tissue.
Pellets of a glass ionomer-silver cement and a zinc oxide-eugenol cement were implanted into the soft tissues and bones of 30 rats. Following experimental periods of 14, 30, and 80 days, the animals were killed and tissue sections were prepared. The responses to each of the materials initially and at 30 days consisted of mild inflammation. No severe inflammatory responses were noted in any of the groups. By 80 days, although mild inflammation persisted, the materials appeared to be well tolerated. Bone apposition occurred in the glass ionomer-silver cement group; the zinc oxide-eugenol group produced fibrosis.
Blackman
R
R
Gross
M
M
Seltzer
S
S
D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000187:drug effects; D016722:Cermet Cements; D003722:Dental Alloys / Q000633:toxicity; D003738:Dental Cements / Q000633:toxicity*; D005899:Glass Ionomer Cements / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver / Q000633:toxicity
D001672:Biocompatible Materials; D016722:Cermet Cements; D003722:Dental Alloys; D003738:Dental Cements; D005899:Glass Ionomer Cements; D012834:Silver