A comparative study of the effect of ten non-steroidal anti-inflammatory drugs (NSAIDs) upon some mitochondrial and platelet functions.
1. Ten different NSAIDs were used in a comparative study of their effects upon rat liver mitochondrial and human platelet functions. 2. The drugs behaved like uncouplers of mitochondrial respiration, decreased membrane potential, stimulated ATPase activity and had an ionophore-like effect upon calcium transport. 3. In vitro experiments showed the same effect with 45Ca as well as 22Na. 4. In platelets, aggregation was considerably reduced by most NSAIDs. 5. Addition of ADP (mitochondrial calcium uptake) or magnesium (platelet aggregation and in vitro cation transference) contributed to protect from those effects.
Baños
G
G
Departamento de Bioquimica, Instituto Nacional de Cardiologia Ignacio Chavez, México, D.F. México.
Reyes
P A
PA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007476:Ionophores; D010975:Platelet Aggregation Inhibitors; D000251:Adenosine Triphosphatases; D002118:Calcium