Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice.
The effects of 1-methyl-4-phenyl - 1,2,3,6-tetrahydropyridine (MPTP) on immune parameters, and the restorative influence of sodium diethyldithiocarbamate (DTC) or deprenyl were evaluated in mice. The concentrations of dopamine (DA), 3-methoxytyramine (3-MT), 3-4-dihydroxyphenyl acetic acid (DOPAC), and homovanillic acid (HVA), were concomitantly measured in the striatum. MPTP depressed T-cell responses. DTC restored these responses as well as the concentration of striatal DA. Deprenyl had no effect on the concentrations of DA and its metabolites, yet it modified the immune responses alike MPTP. The findings suggest a dopamine pathway could be involved in the brain-controlled immunostimulation afforded by DTC.
Renoux
G
G
Laboratoire d'Immunologie, Faculté de Médecine de Tours, France.
Bizière
K
K
Renoux
M
M
Steinberg
R
R
Kan
J P
JP
Guillaumin
J M
JM
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D015198:Designer Drugs; D004050:Ditiocarb / Q000494:pharmacology*; D004298:Dopamine / Q000031:analogs & derivatives / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D007107:Immune System / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D000090023:Metallothionein 3; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D015198:Designer Drugs; D000090023:Metallothionein 3; D008934:Mitogens; C000715430:Mt3 protein, mouse; D011725:Pyridines; D015102:3,4-Dihydroxyphenylacetic Acid; D012642:Selegiline; D004050:Ditiocarb; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C001746:3-methoxytyramine; D004298:Dopamine; D006719:Homovanillic Acid