Dyskinesia in the primate following injection of an excitatory amino acid antagonist into the medial segment of the globus pallidus.
Injection of an excitatory amino acid antagonist, kynurenic acid, into the medial segment of the globus pallidus of the conscious monkey elicited dyskinesia of the contralateral limbs. In most respects the dyskinesia was indistinguishable from the disorder that is produced by ablation of the subthalamic nucleus, or injection of a GABA antagonist into the subthalamic nucleus. Injections of kynurenic acid into the lateral segment of the globus pallidus, by contrast, did not provoke dyskinesia. The effect of kynurenic acid is attributed to the blockade of neurotransmission from the subthalamic nucleus to the medial pallidal segment, and the results suggest that the neurotransmitter utilised by this pathway is an excitatory amino acid.
Robertson
R G
RG
Department of Cell and Structural Biology, University of Manchester, U.K.
Farmery
S M
SM
Sambrook
M A
MA
Crossman
A R
AR
D000818:Animals; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D005917:Globus Pallidus / Q000187:drug effects / Q000503:physiopathology*; D007736:Kynurenic Acid; D008252:Macaca fascicularis; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*
D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D007736:Kynurenic Acid