title: [Prolactin response to acute administration of growth hormone releasing hormone in patients with uremia].
abstract: The Growth Hormone Releasing Hormone (GH-RH) constitutes the most potent and specific stimulus for Growth Hormone secretion. Nevertheless, in some pathologic situations a Prolactin (PRL) response to GH-RH stimulus is also observed. In order to evaluate the possible effect of GH-RH over seric levels of PRL in uremic patients we carried out a study in a group of ten male patients on hemodialysis (HD), who were given an acute stimulus of GH-RH (an IV 50 mcg. bolus) immediately before and after the HD session, with blood extractions at times -15, 0, 15, 30, 45, 60, and 90 minutes for PRL determinations. The same procedure was carried out in 8 healthy controls. Basal PRL levels in the HD group (14 +/- 3.2 micrograms/L) were significantly greater (p less than 0.01) than control group (3.8 +/- 1.4 micrograms/L). There was no PRL response to GH-RH either in uremic patients before or after HD or in healthy controls. Our results show that there is a significant increase in PRL levels in uremic patients both before and after dialysis with a GH-RH response comparable to healthy subjects.
authors.forename: F
authors.initials: F
authors.lastname: García Martín
authors.forename: S
authors.initials: S
authors.lastname: Donnay Candil
authors.forename: E
authors.initials: E
authors.lastname: Martín Escobar
authors.forename: R
authors.initials: R
authors.lastname: Alvaro
authors.forename: G
authors.initials: G
authors.lastname: de Arriba
authors.forename: R
authors.initials: R
authors.lastname: Requejo
authors.forename: R
authors.initials: R
authors.lastname: Martín Hernández
mesh_terms: D000328:Adult; D000368:Aged; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood*
chemical_list: D011388:Prolactin; D013007:Growth Hormone-Releasing Hormone
vernacular_title: Respuesta de la prolactina a la administración aguda de la hormona liberadora de la hormona de crecimiento en pacientes urémicos.