title: Genetic linkage between Huntington's disease and D4S10 (G8) in Scottish families.
abstract: Genetic linkage between Huntington's disease (HD) and polymorphic DNA markers at the D4S10 locus has been investigated in 16 Scottish families. A maximum lod score of 3.499 at a recombination fraction of 0.07 was found, with 95% confidence limits of 0.02 and 0.22. Only one obvious recombinant was detected, and the wide confidence limits probably reflect the large number of unaffected individuals whose risk could only be estimated empirically.
authors.affiliation: Human Genetics Unit, University of Edinburgh, Western General Hospital, Scotland, UK.
authors.forename: S
authors.initials: S
authors.lastname: Holloway
authors.forename: F A
authors.initials: FA
authors.lastname: Millan
authors.forename: A
authors.initials: A
authors.lastname: Curtis
authors.forename: M
authors.initials: M
authors.lastname: Mennie
authors.forename: D J
authors.initials: DJ
authors.lastname: Brock
mesh_terms: D002894:Chromosomes, Human, Pair 4 / Q000648:ultrastructure*; D015342:DNA Probes; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012606:Scotland
chemical_list: D015342:DNA Probes