Effects of chronic hypoxia and verapamil on cAMP content in tissues and blood plasma.
Changes in cAMP content of tissues of lung, heart and aorta and in blood plasma of rats during chronic hypoxia and administration of verapamil were determined and investigated. The results showed that chronic hypoxia (15 days) obviously increased cAMP content of blood plasma, lung and myocardiac tissues. Verapamil, a calcium agonist, attenuated the increase of cAMP content in blood plasma and lung but did not affect cAMP content of the myocardium. It is suggested that a calcium influx is responsible for the increase in cAMP content.
Yuan
X J
XJ
Cai
Y N
YN
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D000242:Cyclic AMP