[Changes of the release of atrial natriuretic factor (ANF) and its gene transcription in morphine tolerance rat atrium].
Specific radioimmunoassay and molecular hybridization technique were used in the present work. Compared with the control rats, we found for the first time a significant decrease of ANF in plasma and a marked increase of ANF in atria in morphine tolerant rats. Simultaneously a raised level of ANF messenger RNA in morphine tolerant rat atria was observed. It is suggested that the biosynthesis and storage of ANF in atria be increased and its release from atria decreased in morphine tolerant rats.
Hu
Z Z
ZZ
Cui
H A
HA
An
S Z
SZ
Yan
W Y
WY
Zheng
Z X
ZX
Tang
J A
JA
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism*; D004361:Drug Tolerance; D006325:Heart Atria / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D012333:RNA, Messenger; C472610:atrial natriuretic peptide, rat; D009020:Morphine; D009320:Atrial Natriuretic Factor