In vivo inhibition of bovine leukemia virus (BLV) expression.
Bovine leukemia virus-infected sheep were demonstrated to possess a plasma factor that specifically suppresses in vitro virus expression in lymphocyte cultures. This blocking activity is observed even after phytohemagglutinin (PHA) stimulation and is independent of cellular proliferation. Such a factor may play a critical role in the regulation of BLV expression.
Cornil
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Laboratoire Immunogénétique INRA, Ecole Nationale Vétérinaire, Alfort, France.
Levy
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D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000382:microbiology; D005786:Gene Expression Regulation; D001909:Leukemia Virus, Bovine / Q000235:genetics / Q000254:growth & development*; D007942:Leukemia, Experimental / Q000097:blood / Q000382:microbiology*; D008213:Lymphocyte Activation; D012190:Retroviridae / Q000254:growth & development*; D012756:Sheep; D013997:Time Factors; D014762:Viral Interference; D014779:Virus Replication
D000956:Antigens, Viral