Tryptophan hydroxylase activity and 5-hydroxytryptamine-immunoreactive cells in the superior cervical ganglion of hydrocortisone-treated neonatal rats.
Early postnatal glucocorticoid injections led to a large increase in the number of 5-hydroxytryptamine(5-HT)-immunoreactive small cells in the rat superior cervical ganglion. Tryptophan hydroxylase (TPH) activity in ganglia from animals treated with glucocorticoids was not significantly different from saline-injected controls. Both 5-HT immunoreactivity and TPH activity were decreased in ganglia from animals treated with glucocorticoid and the TPH inhibitor parachlorophenylalanine, but not in animals treated with 5-HT uptake inhibitor fluoxetine. These results suggest that 5-HT is synthesized in the small intensely fluorescent (SIF) cells.
Päivärinta
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Laboratory of Molecular Neurobiology, Cornell University Medical College, Burke Rehabilitation Center, White Plains, N.Y. 10605.
Park
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DH
Towle
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AC
Joh
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D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000201:enzymology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007150:Immunohistochemistry; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D014365:Tryptophan Hydroxylase / Q000032:analysis*
D005473:Fluoxetine; D012701:Serotonin; D014365:Tryptophan Hydroxylase; D010134:Fenclonine; D006854:Hydrocortisone