title: Radionuclide evaluation of ventricular function at rest and during exercise in double inlet ventricle.
abstract: We studied ventricular volumes and ejection fraction by radionuclide angiography (equilibrium technique) in 15 patients (aged 3-48 years) with double inlet ventricle not yet submitted to corrective surgery. The end-diastolic volume (measured in nine cases) ranged from 108 to 219 ml/m2 (156 +/- 32), being lower than the normal theoretical value (right plus left ventricle) in six cases. Ejection fraction ranged from 30 to 77% (56.4 +/- 13). The value was significantly higher in the subgroup of 10 patients with a dominant left ventricle as compared to the five cases with dominant right or indeterminate ventricular morphology (63.2 +/- 8.3 versus 42.8 +/- 9, P less than 0.01). In seven of the 15 patients, measurements were obtained both at rest and during dynamic exercise in the semi-upright position. The end-diastolic and end-systolic volumes, stroke volume, ejection fraction underwent a slight non-significant reduction (from 158 +/- 29 to 147 +/- 24 ml/m2, from 58 +/- 16 to 56 +/- 24 ml/m2, from 100 +/- 27 to 90 +/- 24 ml/m2, from 64% +/- 9 to 61% +/- 13). During exercise, ventricular volumes mostly behaved as follows: slight reduction of end-systolic volume, decrease of end-diastolic volume, no increase (no change or decrease) of ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Malattie dell'Apparato Cardiovascolare, Università degli Studi, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Rapezzi
authors.forename: F M
authors.initials: FM
authors.lastname: Picchio
authors.forename: M
authors.initials: M
authors.lastname: Bonvicini
authors.forename: F
authors.initials: F
authors.lastname: Tartagni
authors.forename: I
authors.initials: I
authors.lastname: Rubino
authors.forename: G
authors.initials: G
authors.lastname: Crupi
authors.forename: B
authors.initials: B
authors.lastname: Magnani
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005080:Exercise Test; D005260:Female; D006352:Heart Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013318:Stroke Volume
chemical_list: D013670:Sodium Pertechnetate Tc 99m