title: [The effect of nicotinamide on the activity of the glutathione- glutathione reductase system in subcellular fractions of regenerating rat liver].
abstract: Experiments on white rats have shown that growth rates of the glutathione reductase activity and reduced glutathione concentration in the cytoplasmic fraction of the generating liver tissue and especially in the mitochondrial one are more pronounced with an increase of the nicotinamide dose from 50 mg/kg to 150 mg/kg, than after administration of nicotinamide in a dose of 300 mg/kg. Higher doses of nicotinamide (500 mg/kg) produce less pronounced changes in these parameters.
authors.forename: V R
authors.initials: VR
authors.lastname: Soroka
authors.forename: T G
authors.initials: TG
authors.lastname: Skorobogataia
authors.forename: Z M
authors.initials: ZM
authors.lastname: Skorobogatova
authors.forename: G K
authors.initials: GK
authors.lastname: Siverskiĭ
mesh_terms: D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008115:Liver Regeneration / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats
chemical_list: D009536:Niacinamide; D005980:Glutathione Reductase; D005978:Glutathione
vernacular_title: Vliianie nikotinamida na aktivnost' glutation-glutationreduktaznoĭ sistemy v subkletochnykh fraktsiiakh regeneriruiushcheĭ pecheni krys.