title: Effects of WY 47987 (atrial natriuretic factor 102-126) in patients with renal insufficiency: a placebo-controlled, randomised study.
abstract: We studied renal, hormonal and cardiovascular effects of ANF 102-126 (WY 47987) in seven patients with chronic renal failure (serum creatinine 25-68 mg/l) and in four normal volunteers. ANF or placebo bolus injections were given at 1, 2, and 3 micrograms/kg i.v. (each dose on separate days). As compared to placebo, ANF did not induce changes of renal excretory parameters, of plasma renin and aldosterone or of blood pressure and heart rate in patients. In healthy volunteers, however, the same dose of ANF increased urinary excretion of sodium, potassium, calcium, chloride and phosphorus as well as water, and creatinine clearances, and decreased plasma aldosterone. The data suggest blunted effectiveness of ANF bolus injections in patients with renal insufficiency.
authors.affiliation: Department of Medicine, University of Heidelberg, West Germany.
authors.forename: J F
authors.initials: JF
authors.lastname: Mann
authors.forename: C
authors.initials: C
authors.lastname: Reisch
authors.forename: R
authors.initials: R
authors.lastname: Bergbreiter
authors.forename: D
authors.initials: D
authors.lastname: Karcher
authors.forename: E
authors.initials: E
authors.lastname: Hackenthal
authors.forename: P
authors.initials: P
authors.lastname: Vecsei
authors.forename: J
authors.initials: J
authors.lastname: Nussberger
authors.forename: E
authors.initials: E
authors.lastname: Ritz
mesh_terms: D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010446:Peptide Fragments / Q000009:adverse effects / Q000627:therapeutic use*; D010758:Phosphorus / Q000652:urine; D011188:Potassium / Q000652:urine; D016032:Randomized Controlled Trials as Topic; D012083:Renin / Q000097:blood
chemical_list: D010446:Peptide Fragments; C042703:anaritide; D010758:Phosphorus; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D011188:Potassium