title: [Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
abstract: The intrahippocampal injection of two agonists of excitatory aminoacid (EAA) receptors elicited neuronal damages localized in CA1 and dentate gyrus for N-methyl-D-aspartate (NMDA) (20 nmol) and extended to the various hippocampal areas, except dentate gyrus for kainic acid (KA) (2.5 nmol). The pretreatment of the animals with N-[1-(2-thienyl)cyclohexyl]piperidine (TCP) (20 mg/kg), a noncompetitive NMDA-receptor antagonist, prevented the neuronal injury induced by NMDA and KA in CA1. The distribution of neuronal damages and of TCP-protected areas closely correlated to that of EEA-receptors and of TCP binding sites in the hippocampus.
authors.affiliation: Laboratoire de Médecine Expérimentale, Institut de Biologie, Montpellier.
authors.forename: M
authors.initials: M
authors.lastname: Belaidi
authors.forename: G
authors.initials: G
authors.lastname: Rondouin
authors.forename: M
authors.initials: M
authors.lastname: Lerner-Natoli
authors.forename: P
authors.initials: P
authors.lastname: N'Gouemo
authors.forename: J M
authors.initials: JM
authors.lastname: Kamenka
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000293:injuries; D013287:Illicit Drugs / Q000009:adverse effects; D007608:Kainic Acid / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D010622:Phencyclidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D013287:Illicit Drugs; D001224:Aspartic Acid; D016202:N-Methylaspartate; C012058:tenocyclidine; D010622:Phencyclidine; D007608:Kainic Acid
vernacular_title: Lésions excitotoxiques de l'hippocampe chez le rat: implication des récepteurs au N-méthyl-D-aspartate.