title: Cardiac transplantation: a prospective comparison of ketamine and sufentanil for anesthetic induction.
abstract: The hemodynamic effects of ketamine, 1.5 mg/kg, or sufentanil, 3.4 +/- 0.3 micrograms/kg, were studied prospectively for the anesthetic induction of 20 patients with cardiomyopathies undergoing cardiac transplantation. Plasma epinephrine (EPI), norepinephrine (NE), and sufentanil levels were also obtained. Measurements were taken at various times before induction and following intubation. Following ketamine, progressive increases (P less than 0.05) in mean arterial pressure (28%, MAP), mean pulmonary artery pressure (56%, PAP), central venous pressure (109%, CVP), and pulmonary capillary wedge pressure (84%, PCWP) occurred over time, whereas the cardiac index (CI), stroke volume index (SVI), and stroke work index (SWI) remained unchanged or decreased. The use of sufentanil was associated with no significant changes in MAP, PAP, CVP, PCWP, CI, SVI, or SWI. The heart rate (HR) did not significantly change in either group. Plasma NE significantly increased (31%) in the ketamine group, peaking at 10 minutes; whereas EPI levels did not significantly change in either group. Plasma sufentanil did not reflect the microgram/kg or microgram/BSA administered dose, suggesting individualized distribution kinetics. Since perioperative morbidity and mortality did not differ between groups, both ketamine and sufentanil are acceptable drugs for the anesthetic induction for cardiac transplantation. However, the dissimilar hemodynamic effects caused by ketamine and sufentanil suggest that this conclusion may not be applicable to the patient with a cardiomyopathy undergoing noncardiac surgery.
authors.affiliation: Loyola University of Chicago, Foster G. McGaw Hospital, Stritch School of Medicine, Maywood, IL.
authors.forename: G E
authors.initials: GE
authors.lastname: Gutzke
authors.forename: K B
authors.initials: KB
authors.lastname: Shah
authors.forename: S N
authors.initials: SN
authors.lastname: Glisson
authors.forename: R W
authors.initials: RW
authors.lastname: Griesemer
authors.forename: B S
authors.initials: BS
authors.lastname: Kleinman
authors.forename: P M
authors.initials: PM
authors.lastname: Healy
authors.forename: R
authors.initials: R
authors.lastname: Pifarre
authors.forename: T L
authors.initials: TL
authors.lastname: Rao
mesh_terms: D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D016027:Heart Transplantation / Q000379:methods; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D017409:Sufentanil; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000777:Anesthetics; D002245:Carbon Dioxide; D007649:Ketamine; D017409:Sufentanil; D010100:Oxygen; D005283:Fentanyl; D009638:Norepinephrine