Lonidamine versus polychemotherapy in advanced non-small-cell lung cancer. A preliminary analysis.
No clear evidence of survival benefit has been definitely shown by chemotherapy in advanced non-small-cell lung cancer. We evaluated in a randomized trial the activity of the new drug lonidamine (up to 1050 mg/day) versus MVP (mitomycin C, 10 mg/m2, vinblastine, 5 mg/m2, cisplatin, 100 mg/m2). The preliminary findings on 25 patients showed that lonidamine can be easily administered at these dose ranges, and main toxicity was represented by myalgia and testicular pain. Tolerance to combination chemotherapy (MVP) was superimposable to our prior experience. Responses were recorded in both arms, and no survival difference was apparent. The study is in progress.
Giaccone
G
G
Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy.
Bagatella
M
M
Donadio
M
M
Bonardi
G
G
Maestroni
F
F
Calciati
A
A
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007191:Indazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use*; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use
D000970:Antineoplastic Agents; D007191:Indazoles; D008937:Mitomycins; D011720:Pyrazoles; D014747:Vinblastine; D002945:Cisplatin; C016371:lonidamine