title: Single photon emission computed tomography (SPECT) with [123I]IMP in the differential diagnosis of psychiatric disorders.
abstract: Single photon emission computed tomography (SPECT) with [123I]N-isopropyl iodoamphetamine--[123I]IMP--was used to study regional cerebral blood flow (rCBF) in 94 psychiatric patients and six controls. Patients with dementias had distinct brain-image patterns, consistent with the expected neuropathology. Major depressives had decreased cortical and subcortical rCBF. Increased caudate rCBF was observed in schizophrenics and other psychoses with positive symptoms. SPECT is a practical method of functional brain imaging with potential in the differential diagnosis of neuropsychiatric disorders. Further studies are needed to assess the effect of other variables on brain-image patterns.
authors.affiliation: Department of Psychiatry, St. Vincent's Hospital and Medical Center, New York, NY 10011.
authors.forename: R A
authors.initials: RA
authors.lastname: O'Connell
authors.forename: R L
authors.initials: RL
authors.lastname: Van Heertum
authors.forename: S B
authors.initials: SB
authors.lastname: Billick
authors.forename: A R
authors.initials: AR
authors.lastname: Holt
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez
authors.forename: H
authors.initials: H
authors.lastname: Notardonato
authors.forename: D
authors.initials: D
authors.lastname: Luck
authors.forename: L N
authors.initials: LN
authors.lastname: King
mesh_terms: D015526:AIDS Dementia Complex / Q000000981:diagnostic imaging / Q000523:psychology; D000328:Adult; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000523:psychology; D000662:Amphetamines; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000523:psychology; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000098:blood supply; D002540:Cerebral Cortex / Q000098:blood supply; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging* / Q000523:psychology; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000523:psychology; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000000981:diagnostic imaging; D012565:Schizophrenic Psychology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine