[The number and ultrastructure of CD4+ lymphocytes in the blood of healthy persons and in patients with type 1 diabetes mellitus].
The flowing cytofluorometric and electron microscopic methods have been used to study the content and ultrastructure of blood CD4 lymphocytes in healthy and type I diabetic patients. Analysis of submicroscopic structure of the lymphocytes expressing CD4 antigen has revealed its morphological heterogeneity. It has permitted distinguishing four groups of cells. A decrease of the content of CD4+ lymphocytes at the expense of the first group cells and relative increase in the number of the fourth-group cells are observed in the majority of diabetic patients. The availability of parallel-tubular structures in granules forming clusters and first-group lymphocytes, an increase in the number and size of granules of the fourth-group are the most typical changes of ultrastructural characteristics.
Khomenko
R M
RM
Gruzov
M A
MA
Shliakhovenko
V S
VS
Lukinov
D I
DI
Komissarenko
S V
SV
Zak
K P
KP
D015704:CD4 Antigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008854:Microscopy, Electron; D012016:Reference Values; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000648:ultrastructure
D015704:CD4 Antigens
Soderzhanie u u'ltrastruktura CD4+-limfotsitov krovi zdorovykh liudeĭ i bo'lnykh sakharnym diabetom I tipa.