[In vitro effect of cefixime against Haemophilus influenzae].
Cefixime activity has been determined against Haemophilus influenzae strains producing or not beta-lactamase, or resistant to ampicillin by non-enzymatic mechanism. All strains are inhibited by a concentration of 1 mg/l of cefixime independently of beta-lactamase secretion. Ampicillin-resistant non beta-lactamase producing strains are inhibited by concentrations of 0.12 - 1 mg/l. MIC50 and MIC90 were, respectively, 0.06 and 0.12 mg/l for ampicillin-susceptible strains and 0.12 and 0.12 mg/l for ampicillin-resistant strains. The activity of cefixime against Haemophilus influenzae was superior to that of other orally administered antibiotics tested in this study: amoxicillin, amoxicillin-clavulanic acid, cefaclor and cefuroxime.
Dabernat
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H
Laboratoire de Bactériologie, CHU Purpan, Toulouse.
Delmas
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C
D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases
D000900:Anti-Bacterial Agents; D020682:Cefixime; D001618:beta-Lactamases; D002439:Cefotaxime
Activité in vitro du céfixime sur Haemophilus influenzae.