[Preliminary study of atrial natriuretic peptide in patients with cardiac deficiency and its clinical significance].
Immunoreactive atrial natriuretic peptide (irANP) has been measured in 24 patients of various cardiac diseases by radioimmunoassay. According to the TCM, these patients were divided into 4 groups: cardiac energy deficiency mild (A) and severe (B) groups; simple cardiac deficiency (C); and the control (D). The New York Heart Association (NYHA) classification of cardiac function in 5 cases of group A were all degree IV; in 6 cases of group B were 2 of degree IV and 4 of degree III; in 6 cases of group C were 1 of degree III, 3 of degree II and 2 of degree I; and in 6 cases of group D were all degree I. The results of chest X-ray and echocardiogram suggested that the classification of cardiac function was objective. The quantity of irANP in group A-D and NYHA IV-I decreased gradually and was correlated with left ventricular ejection fraction (r = -0.87, P less than 0.01). The average amounts of irANP in the different TCM groups A-D were at the equivalent levels in the groups NYHA IV-I. Meanwhile it was found that the cardiac energy deficiency patients had abnormality in some parameters of hemorrheology, but no correlation with irANP. It suggested that the diagnosis of cardiac deficiency by TCM was correlated with the different degree of NYHA in the sense of biochemical index of irANP. The irANP might be considered as one of the objective signs of the cardiac energy deficiency, which also might represent the severity of the disease.
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D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006331:Heart Diseases / Q000097:blood*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional
D009320:Atrial Natriuretic Factor