[Demonstration of an interferon alpha receptor in human colonic cancer cells in culture].
The IFN-alpha 2 receptor present in human cancerous colonic cells in culture has a capacity of 1,800 sites per cell with a kd of 0.5 nM. The molecular mass of the interferon alpha 2 (IFN-alpha 2) receptor complex is 134 kd. The IFN-alpha 2 induces the activity of the 2'5' oligoadenylate (2'5' A) synthetase activity in these cells and partly inhibits their growth.
Boissard
C
C
Chelbi Alix
M K
MK
Gali
P
P
Thang
M N
MN
Rosselin
G
G
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis; D001665:Binding Sites; D002455:Cell Division; D003110:Colonic Neoplasms / Q000032:analysis*; D003432:Cross-Linking Reagents; D004790:Enzyme Induction; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000378:metabolism / Q000494:pharmacology; D008970:Molecular Weight; D011971:Receptors, Immunologic / Q000032:analysis* / Q000378:metabolism; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D013388:Succinimides; D014407:Tumor Cells, Cultured
D003432:Cross-Linking Reagents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D013388:Succinimides; D015088:2',5'-Oligoadenylate Synthetase; C011240:dithiobis(succinimidylpropionate)
Mise en évidence du récepteur de l'interféron alpha sur la cellule cancéreuse colique humaine en culture.