title: Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum.
abstract: Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.
authors.affiliation: INSERM U289, Hôpital de la Salpêtrière, Paris, France.
authors.forename: E C
authors.initials: EC
authors.lastname: Hirsch
authors.forename: A M
authors.initials: AM
authors.lastname: Graybiel
authors.forename: L B
authors.initials: LB
authors.lastname: Hersh
authors.forename: C
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology* / Q000503:physiopathology; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology*; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D002795:Choline O-Acetyltransferase