Analysis of genotoxic activity of 16 compounds and mixtures by the Drosophila mosaic test.
The mutagenicity of 16 compounds and mixtures were tested by the Drosophila melanogaster wing mosaic test. Fourteen of them gave negative results, two proved to be mutagenic. The positive compounds were chlor-diamino-toluene and 2-(2,4-dichlorophenoxy) propionic acid. Chlor-diamino-toluene increased the frequency of mitotic recombinations and gene mutations although it was found negative by the sex linked recessive lethal test. 2-(2,4-dichlorophenoxy) propionic acid caused only mitotic recombinations.
Surjan
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D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005838:Genotype; D008938:Mitosis / Q000187:drug effects*; D009030:Mosaicism / Q000187:drug effects* / Q000235:genetics; D009153:Mutagens / Q000633:toxicity*; D010655:Phenylenediamines / Q000633:toxicity
D009153:Mutagens; D010655:Phenylenediamines; D015084:2,4-Dichlorophenoxyacetic Acid; C010571:dichlorprop