title: Short-term efficacy of thyroid hormone supplementation for patients with Down syndrome and low-borderline thyroid function.
abstract: The thyroid function of 44 subjects with Down syndrome who were between 2 and 51 years of age was assessed. Three patients (7%) had hypothyroidism, and in 2 of them high titers of antimicrosomal antibody were detected. Seven additional subjects (16%) had low-borderline thyroid function, 6 with elevated thyroid stimulating hormone. These 7 subjects constituted the cohort for an evaluation of the short-term benefits of thyroid hormone supplementation in the low-borderline thyroid functional state. A double-blind crossover drug placebo trial failed to document any cognitive, social, response time, or physical changes attributable to the 8- to 14-week drug treatment period compared to an untreated matched control group. Results provided no evidence for the efficacy of short-term thyroid hormone therapy for this population.
authors.affiliation: Hannah Khoushi Child Development Center, Haifa Medical Center Israel.
authors.forename: E
authors.initials: E
authors.lastname: Tirosh
authors.forename: Y
authors.initials: Y
authors.lastname: Taub
authors.forename: A
authors.initials: A
authors.lastname: Scher
authors.forename: M
authors.initials: M
authors.lastname: Jaffe
authors.forename: Z
authors.initials: Z
authors.lastname: Hochberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001519:Behavior / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D013974:Thyroxine