title: Immunoactive products of human placenta. II. Direct inhibition of non-MHC restricted cytolytic activity of human CD3 alpha-beta but not CD3 gamma-delta expressing T cell clones.
abstract: The effect of human placental supernatant obtained from explant cultures of caesarean delivery placentae was monitored on both alpha-beta human T cell clones, which display both cytotoxic alloreactivity and non-MHC restricted cytotoxicity against K562 target cells, and gamma-delta ones endowed solely with the latter. It was found that, under appropriate experimental conditions, direct inhibition of the cytolytic activity of alpha-beta T cell clones was exerted by the supernatant. In contrast, gamma-delta T cell clones were unaffected. The relevance of these data to the survival of the fetal allograft is discussed.
authors.affiliation: U262 INSERM, Maternite Baudelocque, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Menu
authors.forename: V
authors.initials: V
authors.lastname: David
authors.forename: A
authors.initials: A
authors.lastname: Bensussan
authors.forename: G
authors.initials: G
authors.lastname: Chaouat
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D008285:Major Histocompatibility Complex; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell