title: The specificity of the zimelidine reaction.
abstract: The first of a series of 5HT reuptake inhibitors, zimelidine was withdrawn because of associated hypersensitivity reactions. There was concern that such reactions might be seen with other compounds of this class. Two depressed patients who had a sensitivity reaction to treatment with zimelidine were crossed over to treatment with fluoxetine and no abnormalities were observed. Both patients remained well during uneventful long term treatment with fluoxetine.
authors.affiliation: St Mary's Hospital Medical School, London.
authors.forename: S A
authors.initials: SA
authors.lastname: Montgomery
authors.forename: R
authors.initials: R
authors.lastname: Gabriel
authors.forename: D
authors.initials: D
authors.lastname: James
authors.forename: C
authors.initials: C
authors.lastname: Hawley
authors.forename: P
authors.initials: P
authors.lastname: Burkitt
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003866:Depressive Disorder / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000139:chemically induced; D013577:Syndrome; D015031:Zimeldine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005473:Fluoxetine; D015031:Zimeldine