Factors influencing the response to hepatitis B vaccination of hemodialysis patients.
The response rate and HBsAG antibody concentrations were examined after hepatitis B vaccination in 78 hemodialysis patients aged between 29 and 79 years. The values were related to age, duration of hemodialysis, body weight, creatinine, urea nitrogen, serum concentrations of beta 2-microglobulin and soluble interleukin-2 receptor (IL-2R). Patients with low anti-HBsAG antibody concentrations (10-100 mU/ml) had significantly higher IL-2R serum concentrations than those with high anti-HBsAG antibody concentrations (greater than 3,000 mU/ml; p less than 0.05). Discriminant multivariate analysis (p = 0.032) revealed the influence (62%) of IL-2R on the response rate while other factors were similar in all patient groups. It is concluded that preactivation of T cells with an increased release of IL-2R may contribute to impaired immune response after hepatitis B vaccination.
Walz
G
G
Abteilung für Allgemeine Innere Medizin und Nephrologie, Freie Universität, Berlin.
Kunzendorf
U
U
Haller
H
H
Keller
F
F
Offermann
G
G
Josimovic-Alasevic
O
O
Diamantstein
T
T
D000328:Adult; D000368:Aged; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology; D014761:Viral Hepatitis Vaccines
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D015375:Receptors, Interleukin-2; D014761:Viral Hepatitis Vaccines