[Malignant melanoma and HIV infection].
Among 1000 patients with HIV infection consecutively examined at our dermatological department during the last 3 years, we diagnosed 4 cases of malignant melanoma. This figure is clearly higher than the statistical incidence of 4-13 cases per 100.000 people a year observed in West Germany. The mean age of our 4 patients and 3 additional cases reported in the literature is 10 years less than the average age found in melanoma patients without HIV infection. These findings indicate an increased risk of malignant melanoma in patients with HIV infection. In most of our patients, the cellular immunity was only marginally impaired, corresponding to the stages WR1 and WR2 (Walter Reed classification). Tumor formation, therefore, does apparently not depend on the severity of decompensation of the immunity.
Rasokat
H
H
Universitäts-Hautklinik Köln.
Steigleder
G K
GK
Bendick
C
C
Müller
S
S
Meller
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000150:complications / Q000276:immunology; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
Malignes Melanom und HIV-Infektion.