[TRH dissociates the aggressivity of vegetative and motor phenomena induced by carbachol in the cat].
In these experiments interaction of thyrotropin releasing hormone (TRH) and carbachol injected into the cerebral ventricles of unanaesthetized cats has been investigated. Intracerebroventricular (i.c.v.) carbachol as well as i.c.v. TRH produced emotional behaviour, autonomic and motor phenomena. The most impressive feature of i.c.v. carbachol was the aggressive behaviour, whereas that of i.c.v. TRH the autonomic changes. In cats treated with i.c.v. TRH, the aggressive behaviour, but the autonomic and motor changes of i.c.v. carbachol was potentiated. Since there is evidence that carbachol acts mainly on muscarinic M-2 receptors, the potentiation by TRH of aggressive behaviour, but not the autonomic and motor changes induced by carbachol could indicate heterogeneity of central muscarinic M-2 receptors.
Samardzić
R
R
Institut de Pharmacologie, Faculté de Médecine, Belgrade, Yougoslavie.
Jovanović-Mićić
D
D
Beleslin
D
D
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D004347:Drug Interactions; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D002217:Carbachol
La TRH dissocie l'agressivité des phénomènes végétatifs et moteurs induits par le carbachol chez le chat.