In vitro studies with dimethyldithiocarbamate, possible new antimicrobial for use in poultry.
Tests were conducted to determine the in vitro efficacy of the dithiocarbamate analogue, dimethyldithiocarbamate (DmDTC), against selected poultry pathogens. Organisms studied were two bacteria, Pasteurella multocida and Escherichia coli, and a mold, Aspergillus fumigatus. Zone of inhibition and the minimum inhibitory concentration were determined for each organism. DmDTC was effective in vitro against all organisms tested, with A. fumigatus showing greatest overall sensitivity.
Delap
S K
SK
Department of Animal and Poultry Sciences, University of Arkansas, Fayetteville 72701.
Skeeles
J K
JK
Kreider
D L
DL
Whitfill
C E
CE
Beasley
J N
JN
Houghten
G E
GE
Walker
E M
EM
Cannon
D J
DJ
D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary; D001232:Aspergillus fumigatus / Q000187:drug effects*; D004125:Dimethyldithiocarbamate / Q000494:pharmacology* / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary; D008826:Microbial Sensitivity Tests; D010325:Pasteurella / Q000187:drug effects*; D010326:Pasteurella Infections / Q000188:drug therapy / Q000662:veterinary; D011200:Poultry; D011201:Poultry Diseases / Q000188:drug therapy; D013859:Thiocarbamates / Q000494:pharmacology*
D004125:Dimethyldithiocarbamate; D013859:Thiocarbamates