title: Actions of medroxyprogesterone acetate on the efficacy of cytotoxic drugs: studies with human breast cancer cells in culture.
abstract: Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pre-treatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and 100 nM, was independent of its growth-inhibitory action. These findings confirm a previous clinical study and have important implications with regard to the management of advanced breast cancer.
authors.affiliation: Breast Clinic, St. Mary's Hospital, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Shaikh
authors.forename: A M
authors.initials: AM
authors.lastname: Owen
authors.forename: M W
authors.initials: MW
authors.lastname: Ghilchik
authors.forename: H
authors.initials: H
authors.lastname: Braunsberg
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D008727:Methotrexate / Q000008:administration & dosage; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D008727:Methotrexate