title: Effects in vivo and in vitro of benthiocarb on developing rat (Wistar strain) brain Mg2+ and Ca2+-ATPases.
abstract: Effects in vivo and in vitro of benthiocarb on developing rat brain Mg2+ and Ca2+-ATPases have been studied. Decreased activities of Mg2+ and Ca2+-ATPases suggests impairment in energy synthesis and utilization processes in developing CNS of rat during benthiocarb poisoning. Effects in vitro of benthiocarb on these enzymes revealed that Km (Michaelis-Menten Constant) of both the enzymes increased whereas Vmax (Maximal velocity) decreased significantly indicating mixed type of inhibition on these enzymes by benthiocarb.
authors.affiliation: Department of Zoology, Sri Venkateswara University, Tirupati, India.
authors.forename: P N
authors.initials: PN
authors.lastname: Srinivas
authors.forename: G R
authors.initials: GR
authors.lastname: Reddy
authors.forename: C S
authors.initials: CS
authors.lastname: Chetty
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D013859:Thiocarbamates; D000255:Adenosine Triphosphate; C037925:benthiocarb; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D002118:Calcium