[Studies on antifertility effect of testosterone undecanoate in combination with danazol in male rats].
Male rats were injected i.m. with 12 mg/kg testosterone undecanoate (TU) twice in the first and once in each of the succeeding 2 months in combination with oral danazol (DZ) of 30 mg/kg/day. Antifertility effects were observed with morphological and functional techniques for half a year. Results showed: reduction of testis weight and seminiferous tubule diameter; decrease of sperm viability and motility in canada epididymidis; and lowering of testosterone levels in testis and phospholipid and protein contents in epididymis. 75 days after treatment spermatogenesis was arrested mainly in the secondary spermatocyte stage with a decrease in sperm count to 0 in the cauda epididymidis. Mating test showed 0% fertility. Testicular testosterone and epididymis phospholipid and protein contents were found to have dropped further. However, all of the above-mentioned changes recovered completely 100 days after cessation of treatment. The authors suggest that TU plus DZ in a suitable dose suppresses spermatogenesis, retards maturation and shortens the survival time of sperm in the epididymis by reducing testosterone levels in the testis.
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D000818:Animals; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011245:Pregnadienes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D011245:Pregnadienes; D013739:Testosterone; C010792:testosterone undecanoate; D003613:Danazol