title: Elevated muscle tissue oxygen tension in short-term insulin-dependent diabetes mellitus.
abstract: In order to assess hemodynamic changes in early phases of insulin-dependent diabetes mellitus, muscle tissue oxygen tensions were determined in 7 newly diagnosed insulin-dependent diabetic patients and in 6 healthy control subjects matched for sex, age and weight. Muscle tissue oxygen tension was measured by polarrographic needle probes while breathing ambient air and oxygen enriched air with an oxygen concentration of 40 per cent as well. Three times during the experiment, heart rates, blood pressures, blood glucose concentrations, and capillary oxygen tensions were obtained. Heart rate, blood pressure, peripheral and autonomic nerve functions did not differ between the 2 groups studied. While breathing ambient air, muscle tissue oxygen tensions were significantly (p = 0.025) higher in the diabetic patients than in the control subjects. In contrast to the control subjects, diabetic patients did not increase muscle tissue oxygen tensions after inhalation of oxygen enriched air despite of an equal increase in capillary oxygen tensions (2p less than 0.05). Local tissue hypoxia does not seem to be a leading cause of hemodynamic abnormalities in the early phases of diabetes.
authors.affiliation: Medizinische Universitätsklinik Tübingen, Division of Endocrinology, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Krönert
authors.forename: W
authors.initials: W
authors.lastname: Grauer
authors.forename: M
authors.initials: M
authors.lastname: Günderoth-Palmowski
authors.forename: A
authors.initials: A
authors.lastname: Schuler
authors.forename: C
authors.initials: C
authors.lastname: Zimmermann
authors.forename: R
authors.initials: R
authors.lastname: Heinrich
authors.forename: D
authors.initials: D
authors.lastname: Luft
authors.forename: M
authors.initials: M
authors.lastname: Eggstein
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010100:Oxygen / Q000032:analysis* / Q000097:blood; D010313:Partial Pressure; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D010100:Oxygen