Continuous monitoring of ventilation in spontaneously breathing anesthetized rats.
A method for continuous monitoring and recording of ventilation rate and tidal volume in spontaneously breathing anesthetized rats is described. The system is based on a hot wire flow meter placed in connection with the tracheotomy tube. In cardiovascular experiments routine monitoring of ventilation was found useful in the following instances: 1) detection of ventilatory disorders, 2) detection of central effects of drugs, 3) interpretation of results in cases where cardiovascular drugs alter ventilatory function.
Paakkari
I
I
Department of Pharmacology and Toxicology, University of Helsinki, Finland.
Järvinen
A
A
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D003061:Codeine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012129:Respiratory Function Tests; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013990:Tidal Volume
D002317:Cardiovascular Agents; D013973:Thyrotropin-Releasing Hormone; D003000:Clonidine; D003061:Codeine; D011224:Prazosin