title: ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane.
abstract: We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione-xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.
authors.affiliation: Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
authors.forename: Y C
authors.initials: YC
authors.lastname: Awasthi
authors.forename: S V
authors.initials: SV
authors.lastname: Singh
authors.forename: H
authors.initials: H
authors.lastname: Ahmad
authors.forename: L W
authors.initials: LW
authors.lastname: Wronski
authors.forename: S K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: E F
authors.initials: EF
authors.lastname: LaBelle
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000493:pharmacokinetics; D001693:Biological Transport, Active; D004789:Enzyme Activation / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D006801:Humans; D009994:Osmolar Concentration; D013696:Temperature; D015262:Xenobiotics / Q000493:pharmacokinetics
chemical_list: D015262:Xenobiotics; C030190:S-(2,4-dinitrophenyl)glutathione; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D005978:Glutathione