title: Clinical aspects of para-tertiary-butylphenolformaldehyde resin (PTBP-FR) allergy.
abstract: Sensitization by para-tertiary-butylphenolformaldehyde resin (PTBP-FR), which is particularly useful as a leather glue, has been known for 30 years. We retrospectively studied the clinical aspects of those patients with a PTBP-FR allergy among 1966 patients in whom contact dermatitis was confirmed by patch testing. A positive patch test to PTBP-FR was present in 30 patients (1.5%), 24 of whom were women. Exposure to PTBP-FR as a cause of the dermatitis was "certain" in 7, "very likely" in 6 and "unclear" in 17. 67.7% of the patients had a multiple allergy. In 43.3% of the patients, a history of atopy was found. No clear association of PTBP-FR sensitization with allergies to phenolformaldehyde resin (P-FR) or free para-tertiary-butylphenol (PTBP) emerged in this group of 30 patients. This study supports the hypothesis that PTBP-FR and P-FR do not contain the same sensitizers. Follow-up of 26 of the 30 patients showed a favourable course, dependent on identification of the source of exposure, avoidance of further contact and absence of sensitization to multiple allergens.
authors.affiliation: Department of Dermatology and Venereology, Erasmus University Rotterdam, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Geldof
authors.forename: I D
authors.initials: ID
authors.lastname: Roesyanto
authors.forename: T
authors.initials: T
authors.lastname: van Joost
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003876:Dermatitis, Atopic / Q000150:complications; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D005557:Formaldehyde / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000009:adverse effects*; D011108:Polymers / Q000009:adverse effects*; D012117:Resins, Synthetic / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D010636:Phenols; D011108:Polymers; D012117:Resins, Synthetic; D005557:Formaldehyde; C014273:p-tert-butylphenolformaldehyde resin; C011529:phenol-formaldehyde resin