Association between aluminum accumulation and cardiac hypertrophy in hemodialyzed patients.
In order to investigate the possible role of aluminum accumulation on the myocardium, 50 stable asymptomatic hemodialysis patients were studied. Patient cardiac status was assessed by echocardiography. A deferroxamine (DFO) test, together with a bone biopsy, was performed to determine the magnitude of AI accumulation. Thus, an increase in serum AI after DFO (delta AI DFO) and stainable cortical bone aluminum (SCBA) were taken as parameters of AI load. Fourteen of 50 patients had no SCBA. They differed from the 36 patients with SCBA in that they had lower left ventricular mass (LVM) (P less than 0.001), increased velocity of circumferential fiber shortening (Vcf) (P less than 0.001), and higher mitral E-F slope (P less than 0.01). In the overall population there was a mild increment in serum AI and in delta AI DFO. The duration of dialysis treatment was correlated with SCBA and delta AI DFO (P less than 0.001). A correlation was observed between LVM and delta AI DFO (P less than 0.001) and between LVM and SCBA (P less than 0.001). Multivariate correlations analysis indicated that these relationships were independent of the duration of dialysis treatment. The present data suggest that, in hemodialysis patients aluminum accumulation may be associated with increased LVM.
London
G M
GM
Centre Hospitalier F.H. Manhes, Fleury-Mérogis, France.
de Vernejoul
M C
MC
Fabiani
F
F
Marchais
S
S
Guerin
A
A
Metivier
F
F
Chappuis
P
P
Llach
F
F
D000328:Adult; D000535:Aluminum / Q000009:adverse effects / Q000032:analysis / Q000097:blood*; D001842:Bone and Bones / Q000032:analysis; D006332:Cardiomegaly / Q000209:etiology* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis
D010281:Parathyroid Hormone; D000535:Aluminum