title: A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2.
abstract: We extended the physical map of the mouse int-2 locus by demonstrating that the site of insertion for mouse mammary tumor virus DNA in plaque-type mammary tumors of GR mice is directly linked to int-2. An additional example of proviral integration is described in which a provirus in a presumed enhancer-insertion mode 15 kilobases upstream of the int-2 promoters is capable of activating expression of the gene at levels typical of other virally induced mammary tumors.
authors.affiliation: Imperial Cancer Research Fund Laboratories, St. Bartholomews Hospital, London, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Peters
authors.forename: S
authors.initials: S
authors.lastname: Brookes
authors.forename: M
authors.initials: M
authors.lastname: Placzek
authors.forename: M
authors.initials: M
authors.lastname: Schuermann
authors.forename: R
authors.initials: R
authors.lastname: Michalides
authors.forename: C
authors.initials: C
authors.lastname: Dickson
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D015183:Restriction Mapping