title: Lesions of transmissible gastroenteritis virus infection in experimentally inoculated pigs suckling immunized sows.
abstract: Intestinal lesions of transmissible gastroenteritis (TGE) virus infection in conventionally reared pigs suckling either nonvaccinated, vaccinated, or previously infected sows were studied by scanning electron microscopy, light microscopy, and immunofluorescent microscopy for TGE viral antigen. Pigs were inoculated with virulent TGE virus when they were 5 or 21 days old and were euthanatized shortly after the onset of diarrhea or 96 hours after inoculation if no diarrhea developed. Pigs inoculated when they were either 5 or 21 days old and suckling nonvaccinated sows developed severe lesions, including swelling and necrosis of enterocytes and severe villus atrophy. Pigs inoculated when they were 5 days old and suckling sows vaccinated with attenuated vaccines developed less-severe villus atrophy, and those suckling sows immunized by exposure to nonattenuated TGE virus developed moderate or no villus atrophy. Pigs inoculated when they were 21 days old and suckling sows vaccinated with attenuated vaccines had severe villus atrophy, whereas those suckling sows immunized by exposure to nonattenuated virus had more-moderate villus lesions. Villus atrophy was inhibited to various degrees in pigs suckling immunized sows, depending in part on the antibody titer in the colostrum and milk.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211.
authors.forename: R A
authors.initials: RA
authors.lastname: Moxley
authors.forename: L R
authors.initials: LR
authors.lastname: Olson
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D003332:Coronaviridae / Q000276:immunology*; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000276:immunology / Q000473:pathology*; D007082:Ileum / Q000648:ultrastructure; D007112:Immunity, Maternally-Acquired; D007413:Intestinal Mucosa / Q000648:ultrastructure*; D007583:Jejunum / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D013552:Swine; D013997:Time Factors; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines