Radioimmunodetection of tumors with monoclonal antiplacental ferritin antibody: preliminary results.
Two mouse monoclonal antiferritin antibodies were employed to detect tumors. In the first case a solitary hepatoma was defined, while in the second one, mediastinal metastases of breast cancer were detected. In both cases serum ferritin levels were raised. The availability of monoclonal antiferritin antibodies offers certain advantages over polyclonal antibodies (ease of production, purification and reproducibility). These antiferritin antibodies may be found useful in diagnosis and therapy of certain tumors.
Moroz
C
C
Rogoff Research Institute, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, Beer-Sheva, Israel.
Lantsberg
Z
Z
Sela
O
O
Cohen
Y
Y
Khodadadi
J
J
Goldstein
J
J
Quastel
M R
MR
Shoenfeld
Y
Y
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D005293:Ferritins / Q000276:immunology*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D051379:Mice; D010920:Placenta / Q000032:analysis
D000911:Antibodies, Monoclonal; D005293:Ferritins