title: Potent selective inhibitors of protein kinase C.
abstract: A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).
authors.affiliation: Research Centre, Roche Products Ltd., Welwyn Garden City, Herts., England.
authors.forename: P D
authors.initials: PD
authors.lastname: Davis
authors.forename: C H
authors.initials: CH
authors.lastname: Hill
authors.forename: E
authors.initials: E
authors.lastname: Keech
authors.forename: G
authors.initials: G
authors.lastname: Lawton
authors.forename: J S
authors.initials: JS
authors.lastname: Nixon
authors.forename: A D
authors.initials: AD
authors.lastname: Sedgwick
authors.forename: J
authors.initials: J
authors.lastname: Wadsworth
authors.forename: D
authors.initials: D
authors.lastname: Westmacott
authors.forename: S E
authors.initials: SE
authors.lastname: Wilkinson
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D017252:CD3 Complex; D002227:Carbazoles / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D007094:Imides; D026121:Indole Alkaloids; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors; D051381:Rats; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D019311:Staurosporine; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D002227:Carbazoles; D007094:Imides; D026121:Indole Alkaloids; D047428:Protein Kinase Inhibitors; D011948:Receptors, Antigen, T-Cell; C049985:staurosporine aglycone; D011493:Protein Kinase C; D019311:Staurosporine