Nuclear magnetic resonance spectroscopic studies of interaction of bis-GMA analogues with phosphatidylcholine liposomes as a model for biomembranes.
The interaction of bis-GMA analogues with dipalmitoylphosphatidylcholine liposomes was studied by 1H and 13C nuclear magnetic resonance spectroscopy. It was found that bis-GMA analogues did not diffuse from liposomes once they were incorporated into the lipid bilayers of dipalmitoylphosphatidylcholine. The mobility of iso-bis-GMA was strongly disturbed by dipalmitoylphosphatidylcholine. The large changes in nuclear magnetic resonance spectra of iso-bis-GMA indicated that the interaction of iso-bis-GMA with dipalmitylphosphatidylcholine was larger than that of bis-GMA. This seems to be due to the chemical structure of iso-bis-GMA with the primary hydroxyl group.
Fujisawa
S
S
School of Dentistry, Tokyo Medical and Dental University, Japan.
Kadoma
Y
Y
Komoda
Y
Y
D001672:Biocompatible Materials; D017438:Bisphenol A-Glycidyl Methacrylate; D055598:Chemical Phenomena; D002621:Chemistry; D003188:Composite Resins; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D010713:Phosphatidylcholines; D011109:Polymethacrylic Acids
D001672:Biocompatible Materials; D003188:Composite Resins; D008081:Liposomes; D010713:Phosphatidylcholines; D011109:Polymethacrylic Acids; D017438:Bisphenol A-Glycidyl Methacrylate