CD30(Ki-1) antigen expression in a subset of gastric mucosal plasma cells and in a primary gastric plasmacytoma.
With the use of frozen sections, 24 different monoclonal antibodies (MoAbs), and an indirect peroxidase technique, the antigenic profile of a well-differentiated primary gastric plasmacytoma was obtained. Corresponding to the normal plasma cell, tumor cells were devoid of HLA-D products and B-cell-restricted differentiation antigens CD19, CD20, CD21, CD22, and CD23 while expressing plasma cell-associated CD24 and CD38 molecules and IgA/lambda. The plasmacytoma furthermore reacted with CD30(Ki-1), a reactivity that for this tumor type has not been reported before. Subsequently, normal gastric mucosae affected by all degrees of chronic gastritis were examined. On the basis of serial sections, 5-15% of CD38(OKT10) reactive mucosal plasma cells were observed to also react with CD30(Ki-1). The authors conclude that the CD30 antigen is not only an activation antigen but is also expressed on a subset of terminally differentiated plasma cells.
Möller
P
P
Institute of Pathology, Heidelberg University, West Germany.
Matthaei-Maurer
D U
DU
Moldenhauer
G
G
D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D005753:Gastric Mucosa / Q000276:immunology* / Q000473:pathology; D015234:HLA-A Antigens / Q000032:analysis; D006801:Humans; D017730:Ki-1 Antigen; D008297:Male; D010950:Plasma Cells / Q000276:immunology*; D010954:Plasmacytoma / Q000276:immunology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D015234:HLA-A Antigens; D017730:Ki-1 Antigen