A study on tea-pigment in prevention of atherosclerosis.
Since Lou Fu-qing et al first reported that tea had effect on the prevention of atherosclerosis (AS) in the 1960s, we have conducted experimental and clinical studies, and found that tea-pigment (TP) could reduce blood coagulability, increase fibrinolysis, prevent platelet adhesion and aggregation, and decrease cholesterol content in aortic walls in vivo (P less than 0.01). In addition, TP was shown to inhibit the proliferation of cultured human aortic smooth muscle cells in normal and elevated LDL circumstance in vitro (P less than 0.01), and decreased the level of T x B2 in platelet-rich plasma and remote myocardial infarction patients (P less than 0.01). TP can be used in the prevention of AS.
Lou
F Q
FQ
Zhang
M F
MF
Zhang
X G
XG
Liu
J M
JM
Yuan
W L
WL
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000517:prevention & control*; D001777:Blood Coagulation / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010860:Pigments, Biological / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011817:Rabbits; D013662:Tea; D013929:Thromboxane B2 / Q000097:blood
D000925:Anticoagulants; D010860:Pigments, Biological; D010975:Platelet Aggregation Inhibitors; D013662:Tea; D013929:Thromboxane B2; D002392:Catechin