title: Hymenoptera venom immunotherapy. I. Induction of T cell-mediated immunity by honeybee venom immunotherapy: relationships with specific antibody responses.
abstract: The specific cell-mediated and humoral immune responses of 14 children allergic to honeybee venom were studied. An 8-day rush venom immunotherapy induced an increase in T proliferative (p less than 0.04) and T suppressive (p less than 0.003) cell-specific activities. Antibody variations, an increase in specific IgG4 (p not equal to 0.05), and a decrease in specific IgE (p less than 0.01) were observed 1 year later. Initial high T suppressive cell activity prevents T proliferative cell increase during rush venom immunotherapy. High initial levels of specific IgG1 and specific IgG4 have opposing effects on the increase in T suppressive cell activity, the former being positively correlated with intensive increase (r = 0.840; p less than 0.005), the latter negatively with T suppressive cell increase (r = -0.709; p less than 0.001). These data indicate that there are interrelationships between the cell-mediated immunity and the antibody responses in honeybee allergy.
authors.affiliation: Laboratoire d'Immunologie, Faculté de Médecine Pitié-Salpétrière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Lesourd
authors.forename: J
authors.initials: J
authors.lastname: Paupe
authors.forename: M
authors.initials: M
authors.lastname: Thiollet
authors.forename: R
authors.initials: R
authors.lastname: Moulias
authors.forename: J
authors.initials: J
authors.lastname: Sainte-Laudy
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D000918:Antibody Specificity; D001514:Bee Venoms / Q000276:immunology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013997:Time Factors
chemical_list: D001514:Bee Venoms