The action of the collagen-Fe2+ complex at tissular level.
The aim of this paper is to know the iron dynamics and action of the collagen-Fe2+ complex at tissular level. The results showed that the collagen-Fe2+ complex is biocompatible at tissular level and the ferrous iron entered the animal organism on the well-known metabolic pathways. When a high dose of the complex was administered, an overloading with hemosiderin of macrophages and hepatocytes was noticed.
Mirancea
N
N
Mirancea
D
D
Caloianu-Iordăchel
M
M
Toader
G
G
Moldovan
L
L
Negroiu
G
G
D000818:Animals; D003094:Collagen / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005296:Ferrous Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D006485:Hemosiderin / Q000378:metabolism; D008297:Male; D008667:Metalloproteins / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D014018:Tissue Distribution
D004338:Drug Combinations; D005296:Ferrous Compounds; D008667:Metalloproteins; C059949:collagen-ferrous complex; C020748:ferrous sulfate; D003094:Collagen; D006485:Hemosiderin