title: Angiotensin II stimulates phosphoinositide turnover in the rat myometrium.
abstract: Angiotensin II (AII) activates rat myometrium phospholipase C resulting in the hydrolysis of phosphoinositides. The response to AII is concentration- and time-dependent, and it is blocked by saralasin. During pregnancy there is a loss of responsiveness to AII at the site of placental implantation that appears to return during parturition.
authors.affiliation: Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210.
authors.forename: F G
authors.initials: FG
authors.lastname: Varol
authors.forename: M
authors.initials: M
authors.lastname: Hadjiconstantinou
authors.forename: F P
authors.initials: FP
authors.lastname: Zuspan
authors.forename: N H
authors.initials: NH
authors.lastname: Neff
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D005260:Female; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology
chemical_list: D010716:Phosphatidylinositols; D000804:Angiotensin II; D012504:Saralasin