Effects of lipoxygenase inhibitors in a model of lens-induced uveitis in dogs.
Uveitis was induced in dogs by intracameral injection of canine lens protein. The lipoxygenase inhibitors phenidone and norhydroguaiaretic acid, and dimethyl sulfoxide decreased fibrin production at 0.5 and 1 hour after induction of uveitis. Phenidone and norhydroguaiaretic acid also inhibited the initial increase in intraocular pressure early in the course of inflammation. Leukotriene B4 in the aqueous was measured by use of radioimmunoassay at 1 hour after inflammation. In control dogs, 230 to 1,700 pg of leukotriene B4/ml was measured; in dogs treated with phenidone, leukotriene B4 was not measured.
Dziezyc
J
J
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Millichamp
N J
NJ
Rohde
B H
BH
Baker
J S
JS
Chiou
G C
GC
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007429:Intraocular Pressure / Q000187:drug effects; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol / Q000494:pharmacology / Q000627:therapeutic use; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D014605:Uveitis / Q000188:drug therapy / Q000662:veterinary*
D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D009637:Masoprocol; C015429:phenidone; D004121:Dimethyl Sulfoxide