title: Review of the significance of pulmonary intravascular macrophages with respect to animal species and age.
abstract: Pulmonary intravascular macrophages (PIMs) have been recognized as the site of substantial uptake of blood-borne particles in the lungs of a number of domestic animal species. Concomitantly, there is a pronounced lung susceptibility to endotoxin in calves, goats, sheep, pigs, and cats. Hemodynamic changes and initial lung injury after endotoxin administration are mediated by arachidonic acid metabolites from a pulmonary source. A significant role of PIMs in regulating pulmonary hemodynamics is implicated.
authors.affiliation: Ciba-Geigy Limited, Experimental Toxicology, Stein Works, Switzerland.
authors.forename: G C
authors.initials: GC
authors.lastname: Winkler
mesh_terms: D000367:Age Factors; D000818:Animals; D002415:Cats; D002417:Cattle; D004285:Dogs; D004730:Endothelium, Vascular / Q000502:physiology*; D004731:Endotoxins / Q000378:metabolism; D006041:Goats; D008168:Lung / Q000098:blood supply*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008833:Microcirculation; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013045:Species Specificity; D013552:Swine
chemical_list: D004731:Endotoxins