Immunological tolerance: new approaches using transgenic mice.
Transgenic technology allows the introduction into the germline of an animal of a known gene coding for a normally foreign antigen, and by means of a specific promoter, the direction of its expression to specific tissues. The antigen is therefore synthesized by the animal as an authentic self molecule, at a particular stage in development, and in a particular site. In this review, J.F.A.P. Miller and colleagues discuss this radically new approach to the investigation of the mechanism of acquired immunological tolerance to self components.
Miller
J F
JF
Morahan
G
G
Allison
J
J
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology; D007515:Islets of Langerhans / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D000952:Antigens, Polyomavirus Transforming; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins