title: Effect of TRK-100, a prostacyclin analogue, on endotoxin-induced enhancement of blood coagulation in rats.
abstract: TRK-100 (0.03, 0.1 and 0.3 mg/kg, p.o.), a chemically stable analogue of prostacyclin, dose-dependently prevented blood coagulation and glomerular fibrin deposition which were enhanced by 4 hr infusion of endotoxin (100 mg/kg) in rats. In addition, TRK-100 suppressed the generation of endotoxin-induced tissue thromboplastin like activity in cultured human endothelial cells.
authors.affiliation: Central Research Institute, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: T
authors.initials: T
authors.lastname: Matsubara
authors.forename: K
authors.initials: K
authors.lastname: Saitoh
authors.forename: M
authors.initials: M
authors.lastname: Yajima
authors.forename: S
authors.initials: S
authors.lastname: Nishio
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013925:Thromboplastin / Q000502:physiology
chemical_list: D004731:Endotoxins; D010975:Platelet Aggregation Inhibitors; C048081:beraprost; D013925:Thromboplastin; D011464:Epoprostenol