title: Nuclear grooves in cytologic preparations. A study of the utility of this feature in the diagnosis of papillary carcinoma.
abstract: The sensitivity and specificity of nuclear grooves and inclusions for papillary carcinoma was investigated in 32 touch preparations and 69 fine needle aspiration cytologic preparations of the thyroid. Ultrastructurally, these grooves and inclusions are cytoplasmic invaginations into the nucleus. Overall, 100% of the papillary carcinomas contained nuclear grooves while only 70% contained inclusions. Grooves, however, could be seen in 70% of nonpapillary neoplasms and in 56% of nonneoplastic conditions of the thyroid, albeit generally fewer in number and often not as distinct. Inclusions were present in 13% of nonpapillary neoplasms and were absent in nonneoplastic conditions. Some nuclei on cytologic preparations contain lines that are probably artifacts of chromatin alignment and do not represent true nuclear grooves. Since such lines may be indistinguishable from true grooves, grooves should be used cautiously and in conjunction with other criteria in the diagnosis of papillary carcinoma.
authors.affiliation: Department of Pathology, University of Miami School of Medicine, FL 33101.
authors.forename: E
authors.initials: E
authors.lastname: Gould
authors.forename: L
authors.initials: L
authors.lastname: Watzak
authors.forename: W
authors.initials: W
authors.lastname: Chamizo
authors.forename: J
authors.initials: J
authors.lastname: Albores-Saavedra
mesh_terms: D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure*; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure