title: [Effect of long-term treatment with guanfacine on selected humoral metabolic indices in patients with primary hypertension].
abstract: An effect of the treatment with guanfacine on the activity of the adreno-sympathetic system, beta-thromboglobulin, beta-endorphin, and blood lipids was studied in 30 patients with the primary arterial blood hypertension. It was found that guanfacine significantly decreases plasma noradrenaline, adrenaline, and dopamine. Moreover, it decreases the excretion of noradrenaline, adrenaline and 4-hydroxy-3-methoxy-phenylglycol. These effects correlate with the drop in both systolic and diastolic blood pressure. A decrease in plasma renin activity was also observed. It correlated with the blood pressure drops. Guanfacine increased beta-endorphin levels while beta-thromboglobulin, total cholesterol and triglycerides levels remained unaffected. The authors suggest that the hypotensive effect of guanfacine is related to the decrease in adreno-sympathetic system activity and plasma renin activity and no effect on the erythrocyte activity and lipids metabolism.
authors.forename: K
authors.initials: K
authors.lastname: Knypl
authors.forename: B
authors.initials: B
authors.lastname: Wocial
authors.forename: J
authors.initials: J
authors.lastname: Chodakowska
authors.forename: E
authors.initials: E
authors.lastname: Brym
authors.forename: E
authors.initials: E
authors.lastname: Czerniewska
authors.forename: J
authors.initials: J
authors.lastname: Wacławek-Maczkowska
authors.forename: K
authors.initials: K
authors.lastname: Kuczyńska
authors.forename: H
authors.initials: H
authors.lastname: Berent
authors.forename: W
authors.initials: W
authors.lastname: Januszewicz
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016316:Guanfacine; D006146:Guanidines; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D008875:Middle Aged; D010648:Phenylacetates; D012083:Renin / Q000097:blood; D013566:Sympathomimetics / Q000378:metabolism; D001615:beta-Endorphin / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D013566:Sympathomimetics; D016316:Guanfacine; D008734:Methoxyhydroxyphenylglycol; D001615:beta-Endorphin; D012083:Renin
vernacular_title: Wpływ przewlekłego leczenia guanfacyna na wybrane wskaźniki humoralne i metaboliczne u chorych z nadciśnieniem tetniczym pierwotnym.