[Inhibitory effect of the adaptation to physical load on the development of spontaneous hereditary hypertension in rats].
In Wistar male rats, regular swimming failed to cause any substantial changes in blood pressure (BP) and induced left ventricular hypertrophy. Along with this, the exercise produced an inhibitory effect on BP elevation and led to left ventricular hypertrophy in SHR male rats. In non-swimming rats of the two strains, BP responsiveness to norepinephrine were insignificantly different, and the response to acetylcholine was higher in the non-swimming SHR rats. The physical exercise resulted in a higher BP response to norepinephrine in the Wistar rats but failed to cause changes in these responses in the SH rats. At the same time, swimming did not alter BP responses to acetylcholine in the Wistar, rats, but contributed to their reduction in the SHR rats.
Dvurechenskaia
G Ia
GIa
Khaliulin
I G
IG
D000109:Acetylcholine / Q000494:pharmacology; D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D006332:Cardiomegaly / Q000209:etiology; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013550:Swimming; D013997:Time Factors
D000109:Acetylcholine; D009638:Norepinephrine
Tormoziashchee vliianie adaptatsii k fizicheskoĭ nagruzke na razvitie spontannoĭ nasledstvennoĭ gipertonii u krys.