[Indoprofen in chronic intermittent peritoneal dialysis: effects in the clearance of small molecules and protein loss].
We studied the effects of indoprofen on urea and creatinine clearance and on protein loss in 6 patients submitted to intermittent peritoneal dialysis. The patients had no evidence of peritonitis. Dialysis fluid contained indoprofen (50 mg/l) or no drug. Mean protein loss into dialysis solution was 51.2 g without and 44.7 g with indoprofen (NS). Urea clearance was 33.3 and 33.6 ml/min and creatinine clearance 24.7 and 36.0 ml/min, respectively (NS). Levels of PGF2 alpha in the dialysate, measured in 2 subjects, were not affected by indoprofen. These results suggest that prostaglandins are not the main factors involved in control of urea and creatinine clearance and protein loss during intermittent peritoneal dialysis.
García-Ortiz
R
R
Campos
G
G
Silva
G
G
Gómez
M
M
Uribe
C
C
Herrera
O
O
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011506:Proteins / Q000032:analysis*; D014508:Urea / Q000378:metabolism
D011506:Proteins; D014508:Urea; D003404:Creatinine; D007216:Indoprofen
Indoprofeno en peritoneo diálisis crónica intermitente: efectos en ladepuración de moleculas pequeñas y perdida de proteinas.