title: Issues pertaining to the impact and etiology of trisomy 21 and other aneuploidy in humans; a consideration of evolutionary implications, maternal age mechanisms, and other matters.
authors.affiliation: School of Public Health, Department of Social and Administrative Health Sciences, University of California, Berkeley 94720.
authors.forename: E B
authors.initials: EB
authors.lastname: Hook
mesh_terms: D000782:Aneuploidy; D005075:Biological Evolution; D002869:Chromosome Aberrations / Q000453:epidemiology; D025063:Chromosome Disorders; D003241:Consanguinity; D004314:Down Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D005260:Female; D005306:Fertilization; D006330:Heart Defects, Congenital / Q000209:etiology; D006801:Humans; D008423:Maternal Age; D015233:Models, Statistical; D009630:Nondisjunction, Genetic; D011247:Pregnancy; D012307:Risk Factors