title: [Chronic granulocytopenia as a main symptom of T gamma-lymphocytosis].
abstract: Routine examination of a 60-year-old woman with long-lasting rheumatic complaints revealed a granulocytopenia in the differential blood count (1% stab cells, 3% segmented) with a normal total leucocyte count (4,200/microliters). It was caused by a lymphoproliferative disease of the granular lymphocytes, which may also be termed T gamma lymphocytosis because of the predominant phenotype. As the lymphocytosis in blood and bone marrow was of minor degree, the diagnosis was confirmed only by immunocytochemical and molecular-genetic demonstration of clonal expansion of the T gamma lymphocytes. The granulocytopenia gradually became more marked and recurrent infections were noted. Treatment with cyclosporin and cortisone brought about remission of the granulocytopenia.
authors.affiliation: Abteilung Hämatologie/Onkologie, Universität Göttingen.
authors.forename: G
authors.initials: G
authors.lastname: Krieger
authors.forename: M
authors.initials: M
authors.lastname: Kneba
authors.forename: G
authors.initials: G
authors.lastname: Ohms
authors.forename: S
authors.initials: S
authors.lastname: Gabius
authors.forename: G A
authors.initials: GA
authors.lastname: Nagel
mesh_terms: D000380:Agranulocytosis / Q000175:diagnosis / Q000209:etiology*; D000943:Antigens, Differentiation / Q000032:analysis*; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D003348:Cortisone / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000175:diagnosis* / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000175:diagnosis*; D008875:Middle Aged; D010641:Phenotype; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000943:Antigens, Differentiation; D003524:Cyclosporins; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG; D003348:Cortisone
vernacular_title: Chronische Granulozytopenie als Leitsymptom einer T gamma-Lymphozytose.