title: The effects of multivitamins and minerals on children with Down syndrome.
abstract: The effects of high-dosage multivitamin and mineral supplements on 15 children with Down syndrome aged between 7.5 and 63 months were studied in a placebo-controlled crossover trial. Active treatment was associated with decreased developmental progress, and various side-effects were reported by the parents. The only suggestions of benefit were parents' observations of improvement in general appearance and skin freshness. However, the parents were willing to continue using the treatment and to recommend it to other parents, despite the side-effects.
authors.affiliation: Department of Child Health, University Hospital of Wales.
authors.forename: R T
authors.initials: RT
authors.lastname: Bidder
authors.forename: P
authors.initials: P
authors.lastname: Gray
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: B K
authors.initials: BK
authors.lastname: Evans
authors.forename: M
authors.initials: M
authors.lastname: Hughes
mesh_terms: D002675:Child, Preschool; D004314:Down Syndrome / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008903:Minerals / Q000627:therapeutic use*; D014815:Vitamins / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D008903:Minerals; D014815:Vitamins