Ibotenic acid stimulates D-[3H]aspartate release from cultured cerebellar granule cells.
The release of D-[3H]aspartate from cultured cerebellar granule cells can be evoked by potassium depolarization or by superfusion with the excitatory amino acids glutamic and aspartic acids. The latter phenomenon is not mediated by N-methyl-D-aspartate (NMDA)-, kainate- or quisqualate-preferring receptors, but is stimulated by ibotenic acid. Excitatory amino acid-stimulated D-[3H]aspartate release is antagonised by L-serine-O-phosphate and riluzole. These compounds did not block potassium-stimulated D-[3H]aspartate release. This pharmacology resembles an excitatory amino acid receptor coupled to inositol phosphate (PI) turnover.
Hubert
J P
JP
Centre de Recherches de Gennevilliers, Rhône-Poulenc Santé, France.
Doble
A
A
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000493:pharmacokinetics*; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007051:Ibotenic Acid / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D010768:Phosphoserine / Q000494:pharmacology; D051381:Rats; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D019782:Riluzole; D013844:Thiazoles / Q000494:pharmacology
D000596:Amino Acids; D010080:Oxazoles; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D013844:Thiazoles; D010768:Phosphoserine; D007051:Ibotenic Acid; D001224:Aspartic Acid; D019782:Riluzole