Effect of atropine and terbutaline on motor activity of the continent caecal reservoir for urine.
The effects of muscarinic receptor blockade (atropine) and of beta-adrenoceptor stimulation (terbutaline) on the motor activity of the continent caecal reservoir for urine were studied in 12 patients during continuous filling of the reservoir. Basal pressure was low at high level filling, but pressure waves with amplitudes of 40 to 50 cm H2O occurred every other minute. The reservoir's functional adaptation, revealed as a diminished amplitude of pressure waves and evident soon after its construction, remained stable at long-term follow-up. Subcutaneously injected atropine or terbutaline did not influence the basal pressure but increased the volume at which the first pressure wave appeared and decreased the wave amplitude and frequency at high filling levels. Intra-reservoir instillation of these drugs did not alter the dynamic behaviour of the reservoir. In selected patients, orally administered anticholinergic drugs or beta 2-adrenoceptor agonists may be useful in the management of hyperactivity in a colonic segment used as a continent reservoir or bladder substitute.
Månsson
W
W
Department of Urology, University Hospital, Lund, Sweden.
Hedlund
H
H
Andersson
K E
KE
D000328:Adult; D000368:Aged; D001285:Atropine / Q000494:pharmacology*; D002432:Cecum / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology*; D014547:Urinary Diversion
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D001285:Atropine; D013726:Terbutaline