Molecular properties of the fungal plasma-membrane [H+]-ATPase.
The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes currently available information on the molecular genetics, protein structure, and reaction cycle of the fungal enzyme. Recent efforts to dissect structure-function relationships are also discussed.
Nakamoto
R K
RK
Department of Human Genetics, Yale School of Medicine, New Haven, Connecticut 06510.
Slayman
C W
CW
D002462:Cell Membrane / Q000201:enzymology; D005800:Genes, Fungal; D007700:Kinetics; D005810:Multigene Family; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology* / Q000235:genetics; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics; D004718:Saccharomycetales / Q000201:enzymology*; D012568:Schizosaccharomyces / Q000201:enzymology* / Q000235:genetics
D006180:Proton-Translocating ATPases