[Changes of the necrotic area and functional indices of the myocardial microcirculatory bed during the treatment of experimental myocardial infarct with nitroglycerin, alpha-tocopherol and sodium nucleinate].
A new non-injection method was used to study the quantitative values characterizing the condition of the microcirculatory channel of the peri-infarct zones of rat myocardium without treatment and in treatment with nitroglycerin, alpha-tocopherol, and sodium nucleinate. In combined administration of these agents the total number of capillaries per unit of tissue volume increased, with subsequent increase of the capillary diameter, the exchange surface and the capacity of the capillary channel. These changes in the micro-circulatory channel were reflected in reduction of the focus of myocardial infarction. The authors discuss the mechanisms of the limiting effect of the complex of agents on restriction of the focus of affection in the early and late terms of myocardial infarction development.
Engibarian
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Agaian
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D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006321:Heart / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000473:pathology; D005996:Nitroglycerin / Q000627:therapeutic use*; D009696:Nucleic Acids / Q000627:therapeutic use*; D012331:RNA, Fungal / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D009696:Nucleic Acids; D012331:RNA, Fungal; D014810:Vitamin E; C013683:sodium nucleinate; D005996:Nitroglycerin
Izmeneniia ploshchadi nekroza i pokazateleĭ sostoianiia mikrotsirkuliatornogo rusla miokarda krys pri lechenii éksperimental'nogo infarkta miokarda nitroglitserinom, al'fa-tokoferolom i natriia nukleinatom.