Platelet aggregation and prostaglandin metabolites in the blood of patients with ischaemic heart disease during antiarrhythmic treatment.
The influence of antiarrhythmic drugs (oral lidocaine, palpitine, Etacizine) on blood platelet aggregation and prostaglandin metabolites was studied in 91 patients with ischaemic heart disease. Lidocaine showed a positive, Etacizine a negative, and palpitine no effect on platelet aggregation. There was no uniform effect of lidocaine on prostaglandin metabolites; it increased the prostacycline and decreased the thromboxane levels. Palpitine increased both prostacyclin and thromboxane levels, whereas Etacizine decreased both metabolites, especially prostacyclin.
Kirichenko
L L
LL
Institute of Stomatology, Moscow, USSR.
Masenko
V P
VP
Gorshkov
V A
VA
Narynski
A K
AK
Kurakina
T I
TI
Morozova
L M
LM
Mamaev
V I
VI
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004206:Disopyramide / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D010640:Phenothiazines / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D008012:Lidocaine; C046818:ethacizine; D005996:Nitroglycerin; D004206:Disopyramide