title: Transition dynamics in experimental gingivitis in humans.
abstract: This study was conducted in order to investigate the dynamics of the gingival inflammatory status during periods of plaque accumulation and thorough oral hygiene. After a period of prophylaxis, 42 volunteers were asked to abstain from all oral hygiene measures for 2 weeks, whereafter oral hygiene was reinstituted. In the absence of oral hygiene, plaque was found at virtually all sites after 7 days and the number of sites with gingivitis increased simultaneously. A reduction in gingival inflammation occurred subsequent to plaque removal. During phases of both plaque accumulation and thorough oral hygiene, sites were found to convert from non-inflamed to inflamed status concurrently, as in the reverse direction. No association between plaque and gingivitis was revealed. The gingival status of a single site was a poor predictor of its status on the subsequent occasion. The proportion of inflamed sites converting to non-inflamed status was greater than the proportion of non-inflamed sites converting to inflamed status at any time. The estimated incidence rate remained fairly constant during both the plaque accumulation phase and the oral hygiene phase, whereas the estimated recovery rate was considerable lower during the plaque accumulation phase compared to oral hygiene phase. The clinical appearance is the outcome of the dynamics between these rates. The steady-state prevalences derived from the estimated "incidence" and "recovery" rates were quite similar to the actual findings after 14 d of plaque accumulation and the subsequent 10 d of thorough oral hygiene.
authors.forename: B
authors.initials: B
authors.lastname: Danielsen
authors.forename: F
authors.initials: F
authors.lastname: Manji
authors.forename: N
authors.initials: N
authors.lastname: Nagelkerke
authors.forename: O
authors.initials: O
authors.lastname: Fejerskov
authors.forename: V
authors.initials: V
authors.lastname: Baelum
mesh_terms: D000328:Adult; D003773:Dental Plaque / Q000503:physiopathology* / Q000517:prevention & control; D003774:Dental Plaque Index; D003777:Dental Prophylaxis; D005260:Female; D005881:Gingiva / Q000502:physiology; D005891:Gingivitis / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index