title: Paraneoplastic rhinophyma and the Leser-Trélat sign.
abstract: A case of the Leser-Trélat sign associated with an underlying malignant haemangiopericytoma is described. In addition, the patient had profound hypoglycaemia and a rhinophyma-like nasal swelling which rapidly resolved post-operatively. The tumour appeared to be secreting a factor(s) which cross-reacted with both insulin receptors to induce hypoglycaemia and epidermal growth factor receptors inducing a profusion of eruptive seborrhoeic warts. It aslo had marked sebotrophic activity. The association of the Leser-Trélat sign with malignant haemangiopericytoma has not previously been described.
authors.forename: S C
authors.initials: SC
authors.lastname: Mayou
authors.forename: J J
authors.initials: JJ
authors.lastname: Benn
authors.forename: P H
authors.initials: PH
authors.lastname: Sonksen
authors.forename: M M
authors.initials: MM
authors.lastname: Black
mesh_terms: D000328:Adult; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006393:Hemangiopericytoma / Q000150:complications*; D006801:Humans; D007642:Keratosis / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D012186:Retroperitoneal Neoplasms / Q000150:complications*; D012224:Rhinophyma / Q000209:etiology*; D012393:Rosacea / Q000209:etiology*
chemical_list: D066246:ErbB Receptors