[Effect of hepatic failure upon the pharmacokinetics of cefixime].
Modifications of cefixime kinetics due to severe impairment of liver function were determined in 9 cirrhotic patients. Cefixime was administered as a single dose of 200 mg and levels were measured by HPLC. Maximum serum concentrations and area-under-the-curves of serum concentrations were not modified. The time for maximum serum concentration was delayed and the cefixime half-life in serum was prolonged, as a reflect of increased volume of distribution resulting from ascites and hypoalbuminemia. Renal clearance increased in these patients, possibly because of reduced extra-renal clearance. No metabolite was detected in serum or urine. Modifications of cefixime kinetics resulting from impaired hepatic function were modest and did not require specific dosage adjustment.
Singlas
E
E
Pharmacie clinique, Hôpital Bicêtre.
Lebrec
D
D
Gaudin
C
C
Montay
G
G
Roche
G
G
Taburet
A M
AM
D000328:Adult; D000368:Aged; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D006207:Half-Life; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D020682:Cefixime; D002439:Cefotaxime
Influence de l'insuffisance hépatique sur la pharmacocinétique du céfixime.