Hypothesis: Alzheimer's disease is a phylogenetic disease.
It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and differentiation during hominid evolution, particularly of the regions liable to Alzheimer pathology, and further occur in Down syndrome [suggesting that genes on chromosome 21 are included in G(x)]. If genes which promoted human brain evolution contribute to the value of G(x), a better understanding of the genomic events which promoted this evolution, using molecular biological techniques, should elucidate the genetic basis of Alzheimer's disease, and vice versa.
Rapoport
S I
SI
Laboratory of Neurosciences, National Institute on Aging, Bethesda, Maryland 20892.
D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000254:growth & development / Q000503:physiopathology; D004314:Down Syndrome / Q000150:complications; D015186:Hominidae; D006801:Humans; D008957:Models, Genetic; D010802:Phylogeny