title: [Computed tomographic and angiographic studies of arterial liver perfusion following intra-arterial infusion chemotherapy using 5-fluoro-2-deoxyuridine].
abstract: Fifty patients with liver metastases from colorectal primaries underwent hepatic intraarterial chemotherapy using 5-fluoro-2-deoxyuridine as an antitumour agent. Repeated computed tomography and angiography of the liver was performed during a follow-up period of a year. Following six months of regional chemotherapy, arterial perfusion abnormalities of the liver were detected in 40 of the total of 50 patients. After one year of intraarterial chemotherapy normal arterial liver perfusion was found in only two patients. Histology revealed thrombotic occlusion or narrowing of hepatic arteries, respectively.
authors.affiliation: Röntgendiagnostische Abteilung des Zentrums für Radiologie des Klinikums der Universität Ulm.
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.forename: K A
authors.initials: KA
authors.lastname: Schumacher
authors.forename: F
authors.initials: F
authors.lastname: Safi
mesh_terms: D000368:Aged; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D005467:Floxuridine
vernacular_title: Computertomographische und angiographische Untersuchungen der arteriellen Leberperfusion nach intraarterieller Infusionschemotherapie mit 5-Fluoro-2-Deoxyuridin.