title: Distinct chromosomal abnormalities in murine leukemia virus-induced T- and B-cell lymphomas.
abstract: We performed a cytogenetic study on 16 murine mature B-cell lymphomas and 10 T-cell lymphomas, using G-banding techniques. All tumors, with the exception of 3 spontaneous B-cell tumors, were induced by various slowly transforming murine leukemia viruses (MuLV). Metaphases were obtained from primary (10 B-cell tumors) and first or second transplant generation lymphomas (6 B-cell and 10 T-cell tumors), all of which were well characterized with respect to phenotypic, histologic and genotypic features. In the T-cell tumors we found relatively simple karyotypic abnormalities, including various numerical aberrations, such as trisomy 15, in line with many earlier reports. However, the majority of B-cell tumors showed a great variety of both structural and numerical chromosomal anomalies. Three B-cell lymphomas had an apparently normal karyotype. No single cytogenetic abnormality occurred commonly in the B-cell lymphomas, but some structural abnormalities were found in more than one stemline, in particular, ins (II) (A1; A2) in 3 tumors, and deletions involving the D-region of chromosome 14 in 3 other lymphomas. These cytogenetic results clearly indicate that the pathogenic mechanisms involved in MuLV-induced (long latency) B-cell lymphomagenesis and (short latency) T-cell lymphomagenesis differ considerably.
authors.affiliation: The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam.
authors.forename: W L
authors.initials: WL
authors.lastname: Vasmel
authors.forename: E A
authors.initials: EA
authors.lastname: Matthews
authors.forename: C P
authors.initials: CP
authors.lastname: Gillis
authors.forename: J
authors.initials: J
authors.lastname: Nieland
authors.forename: E A
authors.initials: EA
authors.lastname: Borst
authors.forename: C J
authors.initials: CJ
authors.lastname: Leupers
authors.forename: C J
authors.initials: CJ
authors.lastname: Melief
authors.forename: R M
authors.initials: RM
authors.lastname: Slater
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes; D002869:Chromosome Aberrations / Q000209:etiology / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D007621:Karyotyping; D009052:Leukemia Virus, Murine; D008223:Lymphoma / Q000209:etiology / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes; D014407:Tumor Cells, Cultured