[Clinical, biochemical and histopathological development of post-transfusional non-A, non-B hepatitis from the acute picture to chronicity during 13.3 years].
This case was of a 45 year old female patient with a post-transfusion non-A non-B hepatitis which was accompanied since an acute phase to hepatic cirrhosis during a period of 159.7 months or 13.3 years. Four hepatic biopsies were carried out and they divided the follow-up into 5 evolutive periods. The biopsies revealed a progressive histologic from chronic persistent hepatitis to an active chronic hepatitis and cirrhosis. The aminotransferases followed a floating course in the whole period, with ALT greater than AST starting from the 3rd period. The 3rd period (from 5th to 8th year) was of least activity of the aminotransferases, and the 4th and 5th periods (from 8th to 13th year) showed the highest activity of ALT. The 2nd period (from 3rd to 5th year) showed the least portion of gamma globulin and the highest of albumin in comparison with the others. There was no connection between the levels of aminotransferases and the values of gamma globulin and albumin in the follow up process. The treatment employed in the 5th evolutive period (prednisone and colchicine) did not present any biochemical improvement.
de Andrade Júnior
D R
DR
Serviço de Clínica Geral e Propedêutica, Faculdade de Medicina, Universidade de São Paulo.
Câmara Lopes
L H
LH
de Souza
F C
FC
de Andrade
D R
DR
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000097:blood* / Q000473:pathology*; D006521:Hepatitis, Chronic / Q000097:blood* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors; D065227:Transfusion Reaction
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003078:Colchicine; D011241:Prednisone
Evolução clínico-bioquímica e histopatologica de hepatite não-A, não-B pós-transfusional, do quadro agudo até a cronicidade, com duração de 13.3 anos.