title: Natriuresis associated with elevated plasma atrial natriuretic hormone during supraventricular tachycardia.
abstract: Elevated plasma levels of atrial natriuretic hormone (ANH) have been found in patients during paroxysmal supraventricular tachycardia (SVT) and other clinical syndromes. However, physiologic effects of this endogenous ANH have not been demonstrated. To determine whether the rise in ANH during SVT is associated with either a natriuresis or kaliuresis, urine sodium and potassium levels were measured in five patients at baseline and during SVT simulated by rapid atrioventricular pacing. Plasma ANH levels increased from 149 +/- 35 pmol/L at baseline to 187 +/- 31 pmol/L (p = 0.007) during SVT. Plasma vasopressin and renin levels were unchanged. Urine sodium levels increased 49% from 1.54 +/- 0.66 mEq/hr at baseline to 2.29 +/- 0.89 mEq/hr (p = 0.044) during SVT, and urine potassium levels increased 22% from 4.14 +/- 0.10 mEq/hr to 5.04 +/- 1.25 mEq/hr (p = 0.018). Urine sodium and potassium levels returned to baseline values 1 hour after pacing. Thus elevated plasma levels of ANH during SVT are associated with both a natriuresis and kaliuresis, which may represent physiologic effects of the endogenously secreted hormone.
authors.affiliation: Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor.
authors.forename: J M
authors.initials: JM
authors.lastname: Nicklas
authors.forename: D A
authors.initials: DA
authors.lastname: Giacherio
authors.forename: D
authors.initials: D
authors.lastname: Moskowitz
authors.forename: J H
authors.initials: JH
authors.lastname: Lemmer
authors.forename: M M
authors.initials: MM
authors.lastname: Kirsh
authors.forename: R J
authors.initials: RJ
authors.lastname: Grekin
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood*; D002496:Central Venous Pressure; D006801:Humans; D009318:Natriuresis; D009994:Osmolar Concentration; D011188:Potassium / Q000652:urine; D013617:Tachycardia, Supraventricular / Q000097:blood* / Q000503:physiopathology / Q000652:urine
chemical_list: D009320:Atrial Natriuretic Factor; D011188:Potassium