Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation.
Catecholestrogens and especially 2-hydroxyestrone (2OH-E1) are estradiol metabolites locally formed in breast cancer cells. The present study demonstrates that the two parent compounds, estradiol (E2) and its metabolite 2OH-E1, exert opposite effects on hormone-sensitive breast cancer cell growth assessed by cell counts and transferrin receptor levels, and also on cell differentiation assessed by secreted proteins such as alpha-lactalbumin and gross cystic disease fluid protein (GCDFP-15). The present findings may highlight estradiol regulation in hormone-sensitive breast cancer cells.
Vandewalle
B
B
Laboratoire d'Endocrinologie Expérimentale, Centre Oscar Lambret, Lille, France.
Lefebvre
J
J
D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism*; D002478:Cells, Cultured; D004958:Estradiol / Q000494:pharmacology*; D002393:Estrogens, Catechol / Q000494:pharmacology*; D004970:Estrone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000032:analysis / Q000096:biosynthesis; D011990:Receptors, Transferrin / Q000032:analysis / Q000378:metabolism
D002393:Estrogens, Catechol; D006894:Hydroxyestrones; D011980:Receptors, Progesterone; D011990:Receptors, Transferrin; D004970:Estrone; D004958:Estradiol; C024980:2-hydroxyestrone