Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.
The production of IL-2 and IL-3 by T cells from mice which had been contact sensitized to TNP and/or tolerized by intravenous injections of TNBS was assayed. Contact sensitization rapidly primes T cells, so that they respond to in vitro restimulation with haptenated syngeneic cells by producing IL-2 and IL-3. This production is strongly inhibited, in an antigen-specific manner, in tolerized mice. At least part of this inhibition can be attributed to the action of suppressor T cells that act by preventing the activation of lymphokine production in vitro. Lymphokine production thus closely parallels the in vivo delayed-type hypersensitivity (DTH) reaction in this system.
Marcinkiewicz
J
J
Department of Immunology, N. Copernicus Medical Academy, Cracow, Poland.
Chain
B
B
D000818:Animals; D000941:Antigens / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis*; D007377:Interleukin-3 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009578:Nitrobenzenes / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology*; D014302:Trinitrobenzenesulfonic Acid / Q000276:immunology
D000941:Antigens; D007376:Interleukin-2; D007377:Interleukin-3; D009578:Nitrobenzenes; D014301:Trinitrobenzenes; D014302:Trinitrobenzenesulfonic Acid