[Changes in the activity of angiotensin-converting enzyme of the lung and systemic hemodynamics in spontaneously hypertensive rats under the effect of galvanic current].
It was shown, that local influence of galvanic current upon the lung angiotensin converting enzyme (ACE) in spontaneously hypertensive rats led to a decrease of systemic blood pressure in consequence of reduced peripheral vascular resistance. The development of the hemodynamic alteration was accompanied by variations of physiological and biochemical indices of the lung ACE-activity. These results indicate that the ACE-dependent processes in the lung play on important role in the mechanisms of vasoconstriction, increase in vascular resistance and development of arterial hypertension.
Karpitskiĭ
V V
VV
Komissarova
N V
NV
Slovesnov
S V
SV
Gomazkov
O A
OA
D000818:Animals; D001794:Blood Pressure; D004558:Electric Stimulation; D006439:Hemodynamics; D006973:Hypertension / Q000503:physiopathology*; D008168:Lung / Q000201:enzymology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D014655:Vascular Resistance; D014661:Vasoconstriction
D007703:Peptidyl-Dipeptidase A
Izmeneniia aktivnosti angiotenzin-prevrashchaiushchego fermenta legkikh i sistemnoĭ gemodinamiki u krys so spontannoĭ gipertenzieĭ pod vliianiem gal'vanicheskogo toka.