[Idiopathic hypoparathyroidism, a syndrome with various clinical expressions: analysis of 10 cases].
We report 10 patients with primary hypoparathyroidism. Age at onset varied from 7 months to 52 years (mean 28); 7 were female. Diagnosis was established at a mean of 4.1 years after the appearance of clinical manifestations. Unexplained hypocalcemia (mean 5.3 mg/dl) and hyperphosphatemia (mean 6.4 mg/dl) were present in all patients. Prevalent symptoms included tetany (9 patients), seizures (5) and hypocalcemic cataracts (4). Clinical manifestations may be grouped into 5 types 1) tetany; 2) seizures; 3) other neurologic disorders (basal ganglia calcification, pseudotumor of the brain, ataxia, nystagmus, hypertonus, paresis); 4) disorders of the lens including fully developed cataracts and 5) skin alterations like psoriasis and others. Some of these run on acute course (seizures, tetany), others a subacute one (skin alterations) while others are rather chronic (cataract and other neurologic disorders). Seizures and electroencephalographic disorders predominate in younger patients while tetany is more prevalent in older subjects.
Pumarino
H
H
Contreras
P
P
Michelsen
H
H
Youlton
R
R
Campino
C
C
Aros
S
S
Basaure
J
J
D000328:Adult; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications* / Q000503:physiopathology; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013577:Syndrome
Hipoparatiroidismo idiopatico, un sindrome con variadas expresiones clinicas: analisis de 10 casos.