Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.
Ostermann
J
J
Institut für Physiologische Chemie der Universität München, FRG.
Horwich
A L
AL
Neupert
W
W
Hartl
F U
FU
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D005033:Ethylmaleimide / Q000494:pharmacology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009491:Neurospora / Q000201:enzymology; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D006360:Heat-Shock Proteins; D000255:Adenosine Triphosphate; D013762:Tetrahydrofolate Dehydrogenase; D006180:Proton-Translocating ATPases; D005033:Ethylmaleimide