title: Intrapleural bupivacaine--technical considerations and intraoperative use.
abstract: The authors evaluated the incidence and type of technical problems associated with blind insertion of intrapleural catheters placed in 21 anesthetized patients and then injected in a double-blind fashion with 0.5% bupivacaine (1.5 mg/kg) or isotonic saline. The patients' chests were then opened, catheter positions located, and the lungs inspected. Eleven of the catheters were located with the tips intrapleurally, three extrapleurally, and seven actually in lung tissue. Eight patients had holes in the lung surface. Three patients had a pneumothorax, two of which were under tension. Plasma bupivacaine levels reached maximal concentrations at about 20 minutes in those with intrapleurally placed catheters, but not until 60 minutes when the catheter had actually penetrated the lung. Significant variations in plasma bupivacaine levels were achieved when the catheter entered lung tissue, with potentially toxic levels in one patient. To evaluate intraoperative analgesic effects, all patients were given a standard anesthetic with isoflurane, oxygen, and a muscle relaxant. There was no significant difference in isoflurane requirement between the groups who had bupivacaine v saline injected into their intrapleural catheters before surgery. It is concluded that blind insertion of intrapleural catheters can be hazardous, especially if followed by positive-pressure ventilation. In addition, catheter placement in lung tissue, which was not uncommon, delays the time for peak plasma concentrations and may increase risk of toxicity. Intrapleural bupivacaine was not found to be a useful adjunct to general anesthesia during thoracotomies.
authors.affiliation: Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City 52242.
authors.forename: T
authors.initials: T
authors.lastname: Symreng
authors.forename: M N
authors.initials: MN
authors.lastname: Gomez
authors.forename: B
authors.initials: B
authors.lastname: Johnson
authors.forename: N P
authors.initials: NP
authors.lastname: Rossi
authors.forename: C K
authors.initials: CK
authors.lastname: Chiang
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia / Q000295:instrumentation / Q000379:methods*; D000768:Anesthesia, General; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002404:Catheterization / Q000009:adverse effects / Q000295:instrumentation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D010994:Pleura; D011013:Pneumonectomy; D011030:Pneumothorax / Q000209:etiology; D012965:Sodium Chloride; D013908:Thoracotomy / Q000379:methods; D013997:Time Factors
chemical_list: D012965:Sodium Chloride; D002045:Bupivacaine