title: Acute lead arsenate poisoning.
abstract: Three cases of acute lead arsenate poisoning which occurred in South Australia during a 12 month interval are described. The case reports demonstrate a number of features of the characteristic clinical syndrome which may follow ingestion of lead arsenate. The recommended management is immediate gastric lavage and subsequent chelation therapy with calcium EDTA and dimercaprol. Early gastric lavage may prevent significant lead absorption. However, arsenic acid (produced in the stomach when lead arsenate reacts with hydrochloric acid) is relatively water soluble and prompt gastric lavage is unlikely to prevent extensive arsenic absorption. It remains controversial as to whether chelation with dimercaprol prevents arsenical neuropathy.
authors.affiliation: Division of Clinical Chemistry, Institute of Medical and Veterinary Science, SA.
authors.forename: G A
authors.initials: GA
authors.lastname: Tallis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001149:Arsenates / Q000097:blood / Q000506:poisoning* / Q000652:urine; D020261:Arsenic Poisoning; D015913:Chelation Therapy; D004112:Dimercaprol / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use; D005751:Gastric Lavage; D006801:Humans; D007854:Lead / Q000097:blood / Q000652:urine; D007855:Lead Poisoning / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged
chemical_list: D001149:Arsenates; D004112:Dimercaprol; D007854:Lead; D004492:Edetic Acid; C045846:lead arsenate