title: A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.
abstract: Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
authors.affiliation: Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C.
authors.forename: J K
authors.initials: JK
authors.lastname: Juang
authors.forename: H W
authors.initials: HW
authors.lastname: Huang
authors.forename: C M
authors.initials: CM
authors.lastname: Chen
authors.forename: H J
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D004249:DNA Damage; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D008962:Models, Theoretical; D010957:Plasmids; D011283:Pregnenes / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology; D013552:Swine
chemical_list: D011283:Pregnenes; C059043:withangulatin A; D004250:DNA Topoisomerases, Type II