[The effect of cimetidine to suppress the reduction of gastric mucosal blood flow caused by immobilization in water--its relationship to noradrenaline].
Reduction of gastric mucosal blood flow has been regarded as being the most important event for the gastric defensive mechanisms. In male Wistar rats immobilized in water, the authors recently studied the effect of cimetidine on the gastric mucosal blood flow and the mechanism for that action of cimetidine. In vivo, animals were divided into four groups (PGE2-treated, PGI2-treated and cimetidine-treated groups and an untreated control group), and mucosal blood flow before and 4 hours after the start of immobilization was determined with the electrolytic hydrogen gas clearance technique. In vitro involving perfusion of the isolated gastric blood vessels, the effect of treatment with PGE2, PGI1 or cimetidine in the presence of stimulation with noradrenaline was assessed. The stress-caused blood flow reduction was significantly suppressed in the PGE2-treated group (26.9% reduction in blood flow), the PGI2-treated group (15.7%) and also in the cimetidine-treated group (39.2%) as compared to the controls in which blood flow was reduced by 58.0% following immobilization. In vitro, cimetidine treatment resulted in a reduction of gastric perfusion pressure by 36.6% at maximum although the reduction was more marked following treatment with PGE2 (44.9% reduction) or PGI2 (49.4%). This result suggests that cimetidine also has a vasodilative action.
Urakawa
T
T
First Department of Surgery, Kobe University School of Medicine, Japan.
Azumi
Y
Y
Nagahata
Y
Y
Takeda
K
K
Ichihara
T
T
Morimoto
H
H
Saito
Y
Y
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010437:Peptic Ulcer / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology
D002927:Cimetidine; D011464:Epoprostenol; D015232:Dinoprostone; D009638:Norepinephrine