title: Quantitative alterations of intramuscular connective tissue in calf muscles of the rat during combined hypoxia and hypokinesia.
abstract: The investigations were designed to study the long-term effect of hypoxia, hypokinesia and of combined hypokinesia and hypoxia on the skeletal muscle in the rat. In the muscles of the hypoxic and hypokinetic animals serious degenerative changes were found and the fibre-type ratio was altered. In the hypoxic animals moderate fibrosis was revealed. In the hypokinetic, and hypokinetic + hypoxic animals the amount of connective tissue was 5 to 10-fold greater in the calf muscles as compared to the control.
authors.affiliation: Department of Morphology, National Institute of Traumatology, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Józsa
authors.forename: A
authors.initials: A
authors.lastname: Réffy
authors.forename: S
authors.initials: S
authors.lastname: Demel
authors.forename: J
authors.initials: J
authors.lastname: Thöring
authors.forename: M
authors.initials: M
authors.lastname: Rapcsák
authors.forename: A
authors.initials: A
authors.lastname: Szöör
authors.forename: J
authors.initials: J
authors.lastname: Hideg
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology*; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005355:Fibrosis; D006651:Histocytochemistry; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology*; D007103:Immobilization / Q000009:adverse effects* / Q000502:physiology; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000473:pathology*; D009243:NAD / Q000378:metabolism; D051381:Rats
chemical_list: D009243:NAD; D008058:Dihydrolipoamide Dehydrogenase; D000251:Adenosine Triphosphatases