title: Pharmacokinetics of vasopressin and atrial natriuretic peptide in anesthetized rabbits.
abstract: The elimination from plasma of the peptide hormones vasopressin (VP) and atrial natriuretic peptide (ANP) as well as the time course of release and elimination of these hormones after a physiological stimulus were studied in anesthetized rabbits. As an inverse relationship was found to exist between carotid sinus pressure and plasma IR-ANP, a decrease in carotid sinus pressure to 60 mm Hg was used to stimulate ANP as well as VP release. The elimination of VP after iv injection involved a rapid initial phase and a slow late component, with corresponding half-life (t1/2) values of 0.9 and 5.4 min, respectively. After reduction of carotid sinus pressure to 60 mm Hg, plasma VP increased significantly within 1 min and reached a maximum at 10 min. When carotid sinus pressure was increased to 160 mm Hg to inhibit VP release, the t1/2 of VP was 1.3 min. The t1/2 of immunoreactive (IR) ANP after iv infusion was 1.2 min. Plasma IR-ANP was significantly increased 2 min after carotid sinus pressure was decreased, and a maximum was observed at 10 min. The t1/2 of IR-ANP after elevation of carotid sinus pressure to 160 mm Hg was 3.2 min. These studies indicate that both VP and IR-ANP are rapidly eliminated in the anesthetized rabbit.
authors.affiliation: Department of Physiology, University of British Columbia, Vancouver, Canada.
authors.forename: K A
authors.initials: KA
authors.lastname: King
authors.forename: C A
authors.initials: CA
authors.lastname: Courneya
authors.forename: C
authors.initials: C
authors.lastname: Tang
authors.forename: N
authors.initials: N
authors.lastname: Wilson
authors.forename: J R
authors.initials: JR
authors.lastname: Ledsome
mesh_terms: D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000493:pharmacokinetics*; D001794:Blood Pressure; D002346:Carotid Sinus / Q000502:physiology; D006207:Half-Life; D006339:Heart Rate; D008297:Male; D011817:Rabbits; D014667:Vasopressins / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D014667:Vasopressins; D009320:Atrial Natriuretic Factor