Prostaglandin A and J: antitumor and antiviral prostaglandins.
Prostaglandin(PG)s of the A and J series are categorized as antitumor, antiviral PGs. They have a reactive alpha, beta-unsaturated carbonyl in the cyclopentenone ring, which could be the active moiety. They are actively incorporated into cells and in part transferred to the nuclei, and lead to cell cycle arrest at G1 or cell death depending on the dose.
Fukushima
M
M
Aichi Cancer Center, Nagoya, Japan.
Kato
T
T
Narumiya
S
S
Mizushima
Y
Y
Sasaki
H
H
Terashima
Y
Y
Nishiyama
Y
Y
Santoro
M G
MG
D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002453:Cell Cycle / Q000187:drug effects; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011454:Prostaglandins A / Q000494:pharmacology* / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D014780:Viruses / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011454:Prostaglandins A; C037112:9-deoxy-delta-9-prostaglandin D2; D015230:Prostaglandin D2