title: Do hospital personnel in hyperendemic areas require immunization against hepatitis B virus (HBV) infection? Is vertical transmission of HBV infection common in this group?
abstract: Medical personnel working in contact with blood and blood-contaminated body fluids are often considered to be a high-risk group for hepatitis B virus (HBV) infection and, as a result, it is recommended that they should be vaccinated against this infection. To find out if this is necessary in a country hyperendemic for HBV infection and to see if parents transmit the infection to their offspring, a total of 336 volunteer hospital employees, and 103 children of 47 of them, were tested for HBsAg, anti-HBc, anti-HBs, HBeAg and anti-HBe using the radioimmunoassay technique. Of these, 242 (72%) were found to have evidence of past or present HBV infection and only 94 (28%) had no such evidence. The infection prevalence in the 47 parents was 68% comparable to that of the total sample. Only 9 of their 103 children were positive for HBV markers. All tested parents of these positive children were either negative for all markers or positive for anti-HBs. The HBV infection prevalence among this hospital population is not different from that of the general Ethiopian population, and vertical transmission appears unlikely in this group. Therefore, mass vaccination of hospital staff in hyperendemic areas is unnecessary.
authors.forename: E
authors.initials: E
authors.lastname: Tsega
authors.forename: J
authors.initials: J
authors.lastname: Horton
authors.forename: E
authors.initials: E
authors.lastname: Nordenfelt
authors.forename: B G
authors.initials: BG
authors.lastname: Hansson
authors.forename: G
authors.initials: G
authors.lastname: Wolde-Hawariat
authors.forename: J
authors.initials: J
authors.lastname: Lindberg
mesh_terms: D000328:Adult; D003428:Cross Infection / Q000517:prevention & control / Q000635:transmission*; D005002:Ethiopia; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control / Q000635:transmission*; D017325:Hepatitis B Vaccines; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008505:Medical Staff, Hospital; D008875:Middle Aged; D009784:Occupational Diseases / Q000517:prevention & control / Q000635:transmission*; D012307:Risk Factors; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
chemical_list: D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines