[HLA antigens in hypertension patients with myocardial hypertrophy of the left ventricle].
As many as 34 patients with essential hypertension (EH) and 66 with hypertrophic cardiomyopathy (HCMP) were examined. Concentric hypertrophy of the myocardium was identified in 14 patients with EH and 35 patients with HCMP. Asymmetric hypertrophy of the myocardium was diagnosed in 20 EH patients and 31 HCMP patients. Distribution of class I and II HLA antigens was examined in all the patients. The high rate of DR1 antigen demonstration was established in patients with associated EH and asymmetric hypertrophy of the myocardium. The patients with associated HCMP and hypertrophy of the myocardium showed the high rate of B40 and DR4 antigen demonstration, those with associated HCMP and asymmetric hypertrophy of the myocardium the high rate of DR1 and DR4 antigen demonstration. The data obtained may be of importance for the formation of the groups at risk for the development of the diseases in question and for their differential diagnosis in doubtful cases.
Dubov
P B
PB
Polianskaia
I S
IS
Gerashchenko
Iu S
IuS
Alekseev
L P
LP
Iurenev
A P
AP
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D006332:Cardiomegaly / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis*; D008297:Male
D015415:Biomarkers; D006680:HLA Antigens
Antigeny HLA u bol'nykh gipertonicheskoĭ bolezn'iu s gipertrofieĭ miokarda levogo zheludochka.