[The activating effect of ceruloplasmin on the development of delayed hypersensitivity in mice].
The influence of ceruloplasmin on the development of delayed hypersensitivity (DHS) and activity of T-suppressors were studied in experiments on intact Balb/c mice. Ceruloplasmin introduced in a dose of 5 mg per 1 kg of weight a day before immunization of animals is shown to have a stimulating effect. The amount of the introduced drug being raised to 200 mg per 1 kg of weight suppressed the ability of organism to form DHS effect rather than increased it. Ceruloplasmin is stated to inhibit induction of DHS suppressors and to exert no effect on the expression of functional activity of the formed suppressors.
Ismaĭlova
I M
IM
Berdinskikh
N K
NK
D000276:Adjuvants, Immunologic; D000818:Animals; D002570:Ceruloplasmin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007116:Immunization, Passive / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D002570:Ceruloplasmin
Aktiviruiushchee vliianie tseruloplazmina na formirovanie giperchuvstvitel'nosti zamedlennogo tipa u mysheĭ.