Autoradiographic study of mu and delta opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy.
Highly selective tritiated ligands and autoradiography have been used to study mu and delta binding sites as well as neutral endopeptidase-24.11 in the dorsal horn of the rat spinal cord. Two weeks and 4 months after dorsal root rhizotomy, both opioid binding sites were dramatically decreased (congruent to 60%). In contrast, the level of neutral endopeptidase-24.11 remained unaltered.
Zajac
J M
JM
I.N.S.E.R.M. U. 266, C.N.R.S. U.A. 498, Paris, France.
Lombard
M C
MC
Peschanski
M
M
Besson
J M
JM
Roques
B P
BP
D000818:Animals; D001345:Autoradiography; D015260:Neprilysin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D013116:Spinal Cord / Q000201:enzymology / Q000378:metabolism*; D013126:Spinal Nerve Roots / Q000502:physiology*; D014316:Tritium
D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D014316:Tritium; D015260:Neprilysin