Effect of PGI-2 on uterine activity in vivo in non-pregnant ovariectomized goats (Capra hircus).
Jugular administration of 200 micrograms PGI-2 salt significantly reduced spontaneous uterine activity in ovariectomized, oestrogen-primed goats; the effect was acute and persisted for about 3 h. Peripheral plasma concentrations of 6-keto-PGF-1 alpha, the stable metabolite of PGI-2, decreased to 50% of initial values after 30 min; but at the start of uterine recovery were in excess of 2 ng.ml-1. Uterine reactivity to both oxytocin and PGF-2 alpha after PGI-2 administration was unaffected.
Cooke
R G
RG
University of Liverpool Veterinary Field Station, South Wirral, Cheshire, UK.
Homeida
A M
AM
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006041:Goats / Q000502:physiology*; D010052:Ovariectomy; D010121:Oxytocin / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects*
D010121:Oxytocin; D015237:Dinoprost; D011464:Epoprostenol