title: [Anal neoplasms. Treatment with radiotherapy and exclusive chemotherapy].
abstract: We report preliminary results on treatment of anal carcinoma by radiotherapy and chemotherapy. Nine patients (mean age 64, 6 females) were treated with 5-fluorouracil and mitomycin C intravenously, associated to radiotherapy (3000 rads in 10 days). The lesion was located in the anal canal in 4 patients and at the anal margin in 5. Good response was observed in every patient with no evidence of recurrence during a 2 to 30 month follow up period (median 16). A greater number of patients and a longer follow up period is required to establish this as a valid alternative to abdomino-perineal surgery for the treatment of anal carcinoma.
authors.forename: S
authors.initials: S
authors.lastname: San Martín
authors.forename: S
authors.initials: S
authors.lastname: Armando
authors.forename: J
authors.initials: J
authors.lastname: Arraztoa
authors.forename: Y
authors.initials: Y
authors.lastname: Morales
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000628:therapy*; D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use; D011379:Prognosis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
chemical_list: D008937:Mitomycins; D005472:Fluorouracil
vernacular_title: Cancer anal. Tratamiento con radioterapia y quimioterapia exclusiva.