title: The efficacy and safety of GR38032F in the prophylaxis of ifosfamide-induced nausea and vomiting.
abstract: The novel 5HT3 receptor antagonist GR38032F was evaluated in the control of emesis induced by the cyclophosphamide analogue ifosfamide. At a dose of 4 mg q 6 h, GR38032F was given to six patients receiving their first dose of ifosfamide infusion (4-6 g/m2 over 24 h); over the 42-h study period, major control of retching and vomiting was achieved in five patients. In the second phase of the study six further patients, in whom high-dose metoclopramide had failed to control emesis, were given 8 mg GR38032F q 6 h; major control of emesis was again observed in five patients. Toxicity attributed to GR38032F was minimal. This selective 5HT3 antagonist is effective and safe in the control of ifosfamide-induced emesis, even in patients resistant to high-dose metoclopramide.
authors.affiliation: CRC Department of Radiation Oncology, Clatterbridge Hospital, Merseyside, U.K.
authors.forename: J A
authors.initials: JA
authors.lastname: Green
authors.forename: S W
authors.initials: SW
authors.lastname: Watkin
authors.forename: P
authors.initials: P
authors.lastname: Hammond
authors.forename: J
authors.initials: J
authors.lastname: Griggs
authors.forename: T
authors.initials: T
authors.lastname: Challoner
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D017294:Ondansetron; D012702:Serotonin Antagonists; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D007093:Imidazoles; D012702:Serotonin Antagonists; D017294:Ondansetron; D007069:Ifosfamide