Five-year results of combined chemotherapy and mediastinal radiation therapy in small cell lung cancer.
Eighty-five patients with small cell lung cancer (limited disease = LD in 39, extensive disease = ED in 46) received the combination of cyclophosphamide, methotrexate, vincristine and CCNU, and mediastinal radiotherapy given simultaneously after the third course of chemotherapy. The duration of treatment was approximately 12 months. A complete response was obtained in 41% of LD and in 15% of ED patients, and a partial response in 38 and 22%, respectively. Median survival was 55 weeks for LD and 37 weeks for ED patients. Two patients (5%) with LD have survived free of disease more than 3 years since their diagnosis.
Bonfill
X
X
Department of Oncology and Radiotherapy, Hospital General Vall d'Hebron, Barcelona, Spain.
Lafuerza
A
A
Saigi
E
E
Palombo
H
H
Carulla
J
J
Fuentes
R
R
Rubio
D
D
Sole
L
L
D018288:Carcinoma, Small Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D008482:Mediastinum / Q000528:radiation effects*; D013997:Time Factors