Gene regulation and DNA C-value paradox: a model based on diffusion of regulatory molecules.
The general idea of the model is that regulatory molecules can move stochastically from site to site along DNA and that according to their chromosomal position, genes should have a more or less high probability to be activated (or repressed) during differentiation. In this model the role of non coding DNA is to maintain genes in a relative position that determines what is usually called the "differentiation programme".
Kupiec
J J
JJ
UER D'Hematologie, LOI CNRS, Institut de Recherche sur les Maladies du Sang, Hopital St Louis, Paris, France.
D002454:Cell Differentiation; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D006801:Humans; D008957:Models, Genetic; D013269:Stochastic Processes
D004251:DNA Transposable Elements