title: Assessment of ST segment depression in patients with cardiac disease after local anesthesia.
abstract: This study found that dental treatment with 2% lidocaine with 1:100,000 epinephrine did not provoke myocardial ischemia, as assessed by greater than or equal to 1 mm of ST segment depression. Although in some cases systolic and diastolic blood pressure and rate pressure product increased slightly after local anesthetic administration, these changes were not statistically significant. Because these patients were medically supervised and compliant with cardiac therapy, this study suggests that such patients are not at great risk while receiving local anesthesia with 1:100,000 epinephrine for routine dental care.
authors.affiliation: VA Medical Center, West Los Angeles.
authors.forename: P J
authors.initials: PJ
authors.lastname: Vanderheyden
authors.forename: R A
authors.initials: RA
authors.lastname: Williams
authors.forename: T N
authors.initials: TN
authors.lastname: Sims
mesh_terms: D000368:Aged; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D001794:Blood Pressure / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology; D003730:Dental Care for Persons with Disabilities; D012534:Dental Scaling; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008340:Mandibular Nerve; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009407:Nerve Block; D014092:Tooth Root / Q000601:surgery
chemical_list: D008012:Lidocaine; D004837:Epinephrine