title: The expression of histocompatibility antigen HLA-DR in cervical squamous epithelium infected with human papilloma virus.
abstract: Uterine cervices with histologic changes suggestive of human papilloma virus (HPV) infection were examined for the presence of papilloma virus capsid antigens and the Class II histocompatibility antigen HLA-DR. The purpose of this study was to determine whether papilloma virus infection could induce HLA-DR expression by squamous cells. This expression would allow squamous epithelium to function as antigen-presenting cells and perhaps initiate the immune response. In 20 cases in which HPV capsid antigens were identified, no HLA-DR expression was noted. HLA-DR expression was noted on Langerhans cells within the squamous epithelium and on mononuclear cells in the underlying lamina propria. HLA-DR-positive cells were also noted between columnar epithelial cells of the endocervix. We conclude that HPV infection does not induce HLA-DR expression in the cells it infects.
authors.affiliation: Ayer Clinical Laboratory, Pennsylvania Hospital, Philadelphia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Warhol
authors.forename: B
authors.initials: B
authors.lastname: Gee
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D002213:Capsid / Q000276:immunology; D002584:Cervix Uteri / Q000276:immunology* / Q000473:pathology; D003218:Condylomata Acuminata / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000276:immunology; D027383:Papillomaviridae / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D006684:HLA-DR Antigens