Effect of methionine and threonine on the hypercholesterolemia induced by polychlorinated biphenyls in rats fed a nonprotein diet.
It was previously reported that the hypercholesterolemia induced by polychlorinated biphenyls (PCB) was influenced by dietary protein quantity and quality. On the other hand, the supplementation of methionine and threonine to a nonprotein diet ameliorated the body weight loss and decreased the urinary urea excretion in rats. We examined the effect of methionine and threonine supplements on the hypercholesterolemia induced by PCB in rats fed a nonprotein diet. The administration of PCB increased plasma cholesterol concentration and the supplements of methionine and threonine to the nonprotein diet significantly accelerated the elevation of plasma level of cholesterol due to PCB feeding. Liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rats fed the nonprotein diet was also elevated by PCB administration and the supplementation of methionine and threonine caused further inducing effect.
Hitomi
Y
Y
Department of Agricultural Chemistry, Nagoya University, Japan.
Yoshida
A
A
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage*; D005243:Feces; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology; D011078:Polychlorinated Biphenyls; D051381:Rats; D011919:Rats, Inbred Strains; D013912:Threonine / Q000494:pharmacology*; D014508:Urea / Q000652:urine; D015431:Weight Loss / Q000187:drug effects
D001647:Bile Acids and Salts; D004044:Dietary Proteins; D013912:Threonine; D014508:Urea; D002784:Cholesterol; D008715:Methionine; D011078:Polychlorinated Biphenyls; D006903:Hydroxymethylglutaryl CoA Reductases