title: Ultrastructural and histochemical assessment of proximal renal tubule in rats during administration of lithium carbonate.
abstract: Rat kidney was studied histochemically and in electron microscope during administration of lithium carbonate for 14 days in doses of 4 mmol/l. Morphological examination demonstrated signs of damage exclusively to the epithelial cells in the proximal tubule. Histochemical examination demonstrated a major reduction of the reactions for succinate dehydrogenase and cytochrome oxidase. No difference was found in the intensity of the reaction for alkaline phosphatase and Ca-ATPase during lithium treatment as compared to controls. Additional observation demonstrated, only in histological examination, an increased number of cells of the macula densa.
authors.forename: M
authors.initials: M
authors.lastname: Beskid
authors.forename: I
authors.initials: I
authors.lastname: Chylak
authors.forename: H
authors.initials: H
authors.lastname: Dybkowska-Kłos
authors.forename: W
authors.initials: W
authors.lastname: Kalisz
mesh_terms: D000818:Animals; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D008094:Lithium / Q000633:toxicity*; D016651:Lithium Carbonate; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016651:Lithium Carbonate; D008094:Lithium