title: Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement.
abstract: In addition to the 150-kDa factor H protein, we have previously described a 43-kDa factor H molecule in human plasma, which probably represents a translational product of the additional 1.8-kb mRNA for factor H. This factor H was isolated from human plasma by means of immunoaffinity chromatography and high-performance liquid chromatography. When tested for its functional activity, this purified 43-kDa H protein was shown to act as cofactor for factor I- mediated cleavage of fluid-phase C3b to iC3b.
authors.affiliation: Institut für Hygiene, Innsbruck, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Misasi
authors.forename: H P
authors.initials: HP
authors.lastname: Huemer
authors.forename: W
authors.initials: W
authors.lastname: Schwaeble
authors.forename: E
authors.initials: E
authors.lastname: Sölder
authors.forename: C
authors.initials: C
authors.lastname: Larcher
authors.forename: M P
authors.initials: MP
authors.lastname: Dierich
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D015153:Blotting, Western; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism*; D003180:Complement C3b Inactivator Proteins / Q000302:isolation & purification / Q000502:physiology*; D017242:Complement Factor H; D003170:Complement Pathway, Alternative; D006801:Humans; D008970:Molecular Weight
chemical_list: D000911:Antibodies, Monoclonal; C493495:CFH protein, human; D003176:Complement C3; D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H