[Changes in AI, B and E apolipoproteins induced by infusion of lipid emulsions in critical patients].
In 24 critically ill patients HDL, LDL and VLDL values and those of apolipoproteins (apo) AI, B and E were evaluated just before (T0) and after 1 (T1), 3 (T3), 5 (T5) hours of intralipid infusion. Baseline levels of such parameters were compared with those obtained in 26 healthy volunteers. The critically ill patients showed lower values of apo AI and B (p less than 0.001) than control patients. In intensive care unit patients, a close relationship between HDL and apo AI (p less than 0.001) and between LDL and apo B (p less than 0.001) was observed in addition to the evidence of apo B and E interconversion. In fact, these apolipoproteins were always significantly correlated (p less than 0.01 a T0 e T3; p less than 0.001 a T1; p less than 0.05 a T5). The knowledge of the apolipoproteins functions could be important for the understanding and the detection of the negative effects that could follow to the infusion of fat emulsions.
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D000328:Adult; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D004655:Emulsions; D005217:Fat Emulsions, Intravenous / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D009104:Multiple Trauma / Q000097:blood* / Q000628:therapy; D010289:Parenteral Nutrition, Total; D010743:Phospholipids; D013024:Soybean Oil
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil
Modificazioni delle apolipoproteine AI, B ed E indotte dall'infusione di emulsioni lipidiche nei pazienti critici.