Stimulation of estrogen receptor mRNA levels in MCF-7 cells by herpes simplex virus infection.
Infection of estrogen-responsive cells (MCF-7) with herpes simplex virus type 1 or 2 stimulates expression of the estrogen receptor message. Experiments on infection with the mutant virus, tsK, together with transfection studies implicate the virion protein, Vmw65, in the response. Cellular protein synthesis is essential for estrogen receptor mRNA expression.
Offord
E A
EA
Institute of Virology, University of Glasgow, Scotland.
Leake
R E
RE
Macnab
J C
JC
D015152:Blotting, Northern; D001943:Breast Neoplasms / Q000235:genetics; D003513:Cycloheximide / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006561:Herpes Simplex / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics*; D018139:Simplexvirus; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000502:physiology
D012333:RNA, Messenger; D011960:Receptors, Estrogen; D014764:Viral Proteins; D003513:Cycloheximide