Protective and immunostimulating activity of a low dose of cyclophosphamide in the experimental infection of mice with foot-and-mouth disease virus.
Administration to mice of a low, non-immunosuppressive dose of cyclophosphamide 4 days before infection with foot-and-mouth disease virus decreases viral replication, enhances the immune response against the virus and prevents pancreatic damage.
Portiansky
E L
EL
Cátedra de Patología II, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina.
DiGirolamo
W M
WM
Laguens
R P
RP
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D005537:Aphthovirus / Q000276:immunology / Q000302:isolation & purification; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005536:Foot-and-Mouth Disease / Q000150:complications / Q000276:immunology / Q000517:prevention & control; D008297:Male; D051379:Mice; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D010179:Pancreas / Q000382:microbiology / Q000473:pathology; D010182:Pancreatic Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D003520:Cyclophosphamide