Evidence for a peroxidatic oxidation of norepinephrine, a catecholamine, by lactoperoxidase.
The electron spin resonance-spin stabilization technique has been applied to identify the o-semiquinone intermediate produced during the lactoperoxidase-catalyzed oxidation of the catecholamine norepinephrine. The results of a rapid scan and spectrophotometric investigation of the reaction clearly indicate a normal peroxidatic pathway of catecholamine degradation.
Metodiewa
D
D
Department of Chemistry, University of Alberta, Edmonton, Canada.
Reszka
K
K
Dunford
H B
HB
D016227:Benzoquinones; D055598:Chemical Phenomena; D002621:Chemistry; D003574:Cytochrome c Group / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006861:Hydrogen Peroxide / Q000378:metabolism; D007784:Lactoperoxidase / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism*; D011809:Quinones / Q000378:metabolism; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D016227:Benzoquinones; D003574:Cytochrome c Group; D011809:Quinones; C025232:semiquinone radicals; D006861:Hydrogen Peroxide; D007784:Lactoperoxidase; D010544:Peroxidases; D013482:Superoxide Dismutase; D015032:Zinc; D009638:Norepinephrine