[Effect of strophanthin and digoxin on the activity of succinate and lactate dehydrogenases and membrane Na+, K+-ATPase in the heart of rats with experimental myocarditis].
In rats with adrenaline-induced myocarditis conditionally therapeutic doses of strophanthin (2.7 mg/kg) and digoxin (0.89 mg/kg) were chosen according to performance of the test of swimming until the complete fatigue. The influence of drugs in these doses on enzymatic activity was evaluated by histochemical methods in heart of control and myocarditis rats. It was found out that both of cardiac glycosides decreased lactate dehydrogenase and membrane Na+, K+-ATPase activity and increased succinate dehydrogenase activity in rats with experimental myocarditis.
Galust'ian
G E
GE
Mikhaĭlov
I B
IB
D000818:Animals; D004077:Digoxin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D006321:Heart / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013328:Strophanthins / Q000627:therapeutic use*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D013328:Strophanthins; D004077:Digoxin; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000254:Sodium-Potassium-Exchanging ATPase; D004837:Epinephrine
Vliianie strofantina i digoksina na aktivnost' suktsinat-laktatdegidrogenaz i membrannoĭ Na+, K+-ATFazy v serdtse krys s éksperimental'nym miokarditom.