title: Chromosome studies of males in an institution for the mentally handicapped.
abstract: Karyotypes were examined in 512 (91.9%) of 557 male patients in an institution for the mentally handicapped. A total of 110 (21.5%) had an abnormal karyotype: 65 (12.7%) with Down's syndrome, 30 (5.9%) with the fragile X syndrome, 13 (2.5%) with autosomal anomalies other than Down's syndrome (12 unbalanced, one balanced), and two (0.4%) with sex chromosome anomalies.
authors.affiliation: Department of Human Genetics, University of Newcastle upon Tyne.
authors.forename: C J
authors.initials: CJ
authors.lastname: English
authors.forename: E V
authors.initials: EV
authors.lastname: Davison
authors.forename: M S
authors.initials: MS
authors.lastname: Bhate
authors.forename: L
authors.initials: L
authors.lastname: Barrett
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic