Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.
In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.
Blackstone
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CD
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Supattapone
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Snyder
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SH
D000818:Animals; D001667:Binding, Competitive; D002122:Calcium Chloride / Q000494:pharmacology; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D005971:Glutamates / Q000502:physiology*; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008297:Male; D010069:Oxadiazoles / Q000494:pharmacology; D011689:Purkinje Cells / Q000502:physiology*; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013403:Sugar Phosphates / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D005971:Glutamates; D007295:Inositol Phosphates; D010069:Oxadiazoles; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D013403:Sugar Phosphates; D004533:Egtazic Acid; D016318:Quisqualic Acid; D002122:Calcium Chloride