Influence of 2,3-dimercaptopropane-1-sulfonate and dimercaptosuccinic acid on the mobilization of mercury from tissues of rats pretreated with mercuric chloride, phenylmercury acetate or mercury vapors.
The efficiency of the sodium salt of 2,3-dimercaptopropanesulfonic acid (DMPS) and meso-dimercaptosuccinic acid (DMSA) to mobilize mercury from tissues has been assessed in rats pretreated with different doses of HgCl2, phenylmercury acetate or exposed to different concentrations of mercury vapors. These pretreatments increase the mercury concentration in the kidney and to a lower extent in the liver. Only exposure to metallic mercury vapor leads to mercury accumulation in the brain. Both chelators mobilize mercury stored in the kidney and the amount of metal excreted in urine following a single administration of DMSA is a good indicator of the renal burden of mercury. The rate of removal is greater after DMPS administration than after DMSA but repeated administration of either agents eventually leads to the same total amount of mercury mobilized from the kidney. The loss of mercury from the liver can be slightly accelerated by repeated administration of the chelators. However, the chelators are inefficient in removing mercury from the brain.
Buchet
J P
JP
Industrial Toxicology Unit, Catholic University of Louvain, Bruxelles, Belgium.
Lauwerys
R R
RR
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D004112:Dimercaprol / Q000031:analogs & derivatives*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008627:Mercuric Chloride / Q000008:administration & dosage* / Q000378:metabolism; D008628:Mercury / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D010662:Phenylmercuric Acetate / Q000008:administration & dosage* / Q000378:metabolism; D010663:Phenylmercury Compounds / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D004113:Succimer / Q000494:pharmacology* / Q000652:urine; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014494:Unithiol / Q000494:pharmacology* / Q000652:urine
D010663:Phenylmercury Compounds; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D014494:Unithiol; D008627:Mercuric Chloride; D004113:Succimer; D008628:Mercury; D010662:Phenylmercuric Acetate