title: cAMP levels in monocytes of heroin addicts.
abstract: Intravenous heroin addicts have a high intracellular cAMP level in relation to control monocytes. Incubation in vitro with ascorbic acid normalizes the cellular content of cAMP. We discuss the role of cAMP in the pathogenesis of defective monocyte chemotaxis in intravenous heroin addicts.
authors.affiliation: Departamento de Patologia General, Hospital Clinico Universitario, Salamanca Hispania.
authors.forename: J L
authors.initials: JL
authors.lastname: Castrillón
authors.forename: J L
authors.initials: JL
authors.lastname: Arellano
authors.forename: J D
authors.initials: JD
authors.lastname: Palomo
authors.forename: M M
authors.initials: MM
authors.lastname: Rodriguez
authors.forename: A J
authors.initials: AJ
authors.lastname: López
mesh_terms: D000293:Adolescent; D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008297:Male
chemical_list: D000242:Cyclic AMP; D001205:Ascorbic Acid