The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide.
We have characterized multiple transcripts from the band 3 gene expressed in rat and mouse kidney. In each species, the major transcript lacks sequence from the first three exons of the band 3 gene. The murine transcript predicts a kidney band 3 polypeptide with a truncated amino terminus, lacking the first 79 amino acids of erythroid band 3. When expressed in Xenopus oocytes this truncated band 3 functions in anion transport.
Brosius
F C
FC
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
Alper
S L
SL
Garcia
A M
AM
Lodish
H F
HF
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics*; D001483:Base Sequence; D015342:DNA Probes; D004262:DNA Restriction Enzymes; D004720:Endonucleases; D004912:Erythrocytes / Q000032:analysis; D005091:Exons; D005260:Female; D007438:Introns; D007668:Kidney / Q000032:analysis*; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D009865:Oocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D015719:Single-Strand Specific DNA and RNA Endonucleases; D014158:Transcription, Genetic; D014982:Xenopus laevis
D001457:Anion Exchange Protein 1, Erythrocyte; D015342:DNA Probes; D012333:RNA, Messenger; D004720:Endonucleases; D004262:DNA Restriction Enzymes; D015719:Single-Strand Specific DNA and RNA Endonucleases