Captopril and hydralazine suppress atrial natriuretic peptide (ANP) gene expression in the ventricles of spontaneously hypertensive rat.
We investigated the influences of captopril (CAP) and hydralazine (HYD) on the ANP mRNA level in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR). Male SHRs (16 weeks of age) were given CAP (35 mg/kg/day) or HYD (3.5 mg/kg/day) for two weeks. Both drugs reduced blood pressure by a similar magnitude. Treatment with CAP caused a reduction in the ANP mRNA level in LV by 62%, and a reduction in the weight of the LV. The ANP mRNA level in LV of the HYD-treated rats was also decreased, but only by 31%. HYD did not affect LV hypertrophy. ANP gene expression in LV of SHR might be effectively suppressed by a reduction of blood pressure and also by the concomitant attenuation of hypertrophy.
Fukui
K
K
Department of Pharmacology, Kagawa Medical School, Japan.
Iwao
H
H
Nakamura
A
A
Yamamoto
A
A
Tamaki
T
T
Shoji
T
T
Kimura
S
S
Aki
Y
Y
Hasui
K
K
Ohkubo
H
H
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002216:Captopril / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D006830:Hydralazine / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR
D012333:RNA, Messenger; D006830:Hydralazine; D009320:Atrial Natriuretic Factor; D002216:Captopril