[Treatment of Schistosomiasis mansoni with a combination oxamniquine and praziquantel. II. Experimental observations during the patent phase].
The efficacy of an association of oxamniquine and praziquantel in the patent phase of experimental schistosomiasis was studied. The mice were infected and divided in four groups in accordance to the following schedules with the use of single oral doses: I--Oxaminiquine (50 mg/kg); II--praziquantel (75 mg/kg); III--association of oxamniquine (50 mg/kg) and praziquantel (75 mg/kg); and IV--no drug. Efficacy was assessed by the oogram technique, studying and classifying the evolution of the output of eggs in fragments of the small intestine, and also by recovery of the worms by portal vein perfusion. In the animals of groups I and II, the drugs had a partial effect while in the group III sinergism was evident.
Campos
R
R
Pinto
P L
PL
Amato Neto
V
V
Moreira
A A
AA
D000284:Administration, Oral; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
D009600:Nitroquinolines; D010073:Oxamniquine; D011223:Praziquantel
Tratamento da esquistossomose mansônica por meio da associação de oxamniquine com praziquantel. II--Observações experimentais relativas à fase patente.