[Immunologic status in physiological pregnancy].
The levels of T gamma- and T mu-lymphocytes, functional activity of ConA-induced T-suppressors and the concentrations of SP1 and SP3 were determined in 164 normal pregnant women during 8-40 weeks of gestation. It is found that formation of the suppressor dominant is necessary for the immunological maintenance during 8-32 weeks of gestation. This dominant is intended to block superfluous maternal immune response to fetal alloantigens. The formation of such a dominant is evoked by high functional activity of ConA-induced T-suppressors and high levels of T gamma-lymphocytes with immunodeficiency of T mu-cells. Results of correlation analysis have shown a relationship between functional activity of T-suppressors and accumulation of two specific pregnancy proteins. It permits determining physiological role of SP1 and SP3 as natural endogenous immunoregulators of T-suppressors.
Chernyshov
V P
VP
Valetskiĭ
V L
VL
Radysh
T V
TV
D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007958:Leukocyte Count; D011247:Pregnancy / Q000276:immunology*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
Immunologicheskoe obespechenie fiziologicheski protekaiushcheĭ beremennosti.