title: Cross-reactivity of anti-ssDNA antibodies with heparan sulfate in patients with type I diabetes mellitus.
abstract: Anti-single-stranded-DNA antibodies cross-reactive with heparan sulfate were detected in serums of patients with type I (insulin-dependent) diabetes mellitus. The results suggested that heparan sulfate, the major glycosaminoglycan constituent of the glomerular basement membrane, may serve as a target antigen in vivo for cross-reactive anti-DNA antibodies. These polyreactive antibodies, directed toward repeating negatively charged units, may neutralize the heparan sulfate-associated polyanionic sites in the glomerulus, leading to an abnormal permeability of anionic plasma proteins.
authors.affiliation: Istituto di Clinica Medica I and Istituto di Clinica Pediatrica, University of Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Triolo
authors.forename: E
authors.initials: E
authors.lastname: Giardina
authors.forename: G
authors.initials: G
authors.lastname: Scarantino
authors.forename: G
authors.initials: G
authors.lastname: Seddio
authors.forename: F
authors.initials: F
authors.lastname: Cardella
authors.forename: F
authors.initials: F
authors.lastname: Meli
authors.forename: G
authors.initials: G
authors.lastname: Bompiani
mesh_terms: D002648:Child; D003429:Cross Reactions; D004277:DNA, Single-Stranded / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006025:Glycosaminoglycans / Q000276:immunology*; D006497:Heparan Sulfate / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis
chemical_list: D004277:DNA, Single-Stranded; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D007074:Immunoglobulin G