Transient post-partum thyroid dysfunction and postnatal depression.
In the course of a population study of thyroid dysfunction in pregnancy and the post-partum period, 65 women, considered to be antibody-positive (microsomal and thyroglobulin), and 82 antibody-negative women were assessed for postnatal depression at 6-8 weeks post partum. The women were also assessed for the development of post-partum thyroid dysfunction. Of the 147 women, 22 met DSM-III criteria for major depression. The presence of autoantibodies showed little association with depressed mood but there was a minor association of postnatal depression with actual thyroid dysfunction in that incidence of the latter condition was higher in depressed women (Raskin scale P less than 0.01; Edinburgh scale P less than 0.05; Montgomery-Asberg scale P less than 0.1). Three of eight mothers with thyroid dysfunction had major depression and were depressed on all three scales.
Harris
B
B
University of Wales College of Medicine, Cardiff, U.K.
Fung
H
H
Johns
S
S
Kologlu
M
M
Bhatti
R
R
McGregor
A M
AM
Richards
C J
CJ
Hall
R
R
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D019965:Neurocognitive Disorders / Q000503:physiopathology* / Q000523:psychology; D011247:Pregnancy; D011569:Psychiatric Status Rating Scales; D011644:Puerperal Disorders / Q000503:physiopathology* / Q000523:psychology; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000503:physiopathology
D001323:Autoantibodies; D013963:Thyroid Hormones; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin