[An association between hepatitis-B antigen-negative infantile papular acrodermatitis and Epstein-Barr virus infection].
The virological studies on 23 patients with infantile papular acrodermatitis (IPA) without hepatitis B virus (HBV)-associated antigens and antibodies were performed. The following results were obtained; 1) There was serological evidence of primary Epstein-Barr virus (EBV) infection in 17 out of 23 cases (74%). 2) The regression assays was done in 5 cases of IPA and 10 cases of infectious mononucleosis known to be associated with primary EBV infection in order to investigate the development of EBV-specific killer T cell activity in the primary EBV infection. The results confirm the evidence for EBV-specific cellular immunity in both patients with IPA and infectious mononucleosis. 3) The in vitro transformation assays was also done in 4 cases of IPA and 10 cases of infectious mononucleosis. Incidence of in vitro spontaneous transformation in the presence of cyclosporin A was significantly higher in patients of IPA and infectious mononucleosis than in the EBV seropositive controls. These results confirm that EBV plays an important role on the pathogenesis of HBV-negative IPA.
Konno
M
M
Department of Pediatrics, Hokkaido University School of Medicine.
D000169:Acrodermatitis / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D002472:Cell Transformation, Viral; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D007244:Infectious Mononucleosis; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male
D000914:Antibodies, Viral