Insulin-induced hypoglycaemia and absorption of injected insulin in diabetic patients.
The effect of insulin-induced hypoglycaemia (soluble insulin 1 mU kg-1 min-1 IV) on the absorption of 125I-labelled soluble insulin (10 U SC) from thigh was studied in 10 insulin-treated Type 1 diabetic patients on a test and a control day. Disappearance of 125I was followed by external gamma counting. Adipose tissue blood flow was measured concomitantly using the 133Xe-clearance technique. Arterial plasma levels of glucose, insulin, adrenaline and noradrenaline were determined intermittently. Hypoglycaemia occurred at a glucose level of 2.2 +/- 0.1 (+/- SE) mmol l-1 after 58 +/- 6 min. Peak levels of adrenaline (6.44 +/- 1.62 nmol l-1) and noradrenaline (2.29 +/- 0.39 nmol l-1) were found 10 min later. During the 30-min period after onset of hypoglycaemia, adipose tissue blood flow increased 132 +/- 45% (p less than 0.05) but the disappearance rate of 125I-insulin was unchanged. Thus, insulin absorption was unaltered in connection with hypoglycaemia in Type 1 diabetic patients, in contrast to the depression previously reported in healthy subjects, despite similar increases in adipose tissue blood flow.
Fernqvist-Forbes
E
E
Department of Medicine, Huddinge Hospital, Stockholm, Sweden.
Gunnarsson
R
R
Linde
B
B
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007328:Insulin / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007457:Iodine Radioisotopes; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011865:Radioisotope Dilution Technique
D001786:Blood Glucose; D007328:Insulin; D007457:Iodine Radioisotopes; D009638:Norepinephrine