[Peroxidative antimalaria mechanism of sodium artesunate].
Peroxidative antimalaria action of sodium artesunate was studied in vitro. Under alkaline conditions, sodium artesunate could produce active oxygen species, including the superoxide anion (O2-) and hydrogen peroxide (H2O2), but no O2- or H2O2 was produced by the drug at pH 7.4. However, sodium artesunate could increase the concentration of O2- and H2O2 in erythrocytes by increasing membrane lipid peroxidation, with this action being more marked in infected than in normal erythrocytes.
Li
F B
FB
Pan
H Z
HZ
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D000077332:Artesunate; D004910:Erythrocyte Membrane / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D010963:Plasmodium falciparum; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; D010100:Oxygen