title: Highly potent and small neuropeptide Y agonist obtained by linking NPY 1-4 via spacer to alpha-helical NPY 25-36.
abstract: Analogues of neuropeptide Y (NPY) containing small N- and C-terminal segments linked via flexible spacer arms were found to exhibit receptor binding affinity constants almost as high as NPY as well as post- and presynaptic NPY-agonistic activities. One of the most active analogues contains N-terminal NPY segment 1-4 linked via epsilon-aminocaproic acid (Aca) to the C-terminal partially alpha-helical peptide amide segment 25-36. NPY 1-4-Aca-25-36 is the first highly potent NPY agonist, which is of considerably reduced size in comparison to the native hormone. The analogues are accessible by solid-phase synthesis using Fmoc strategy.
authors.affiliation: Institut für Organische Chemie, Universität Tübingen, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Beck
authors.forename: G
authors.initials: G
authors.lastname: Jung
authors.forename: W
authors.initials: W
authors.lastname: Gaida
authors.forename: H
authors.initials: H
authors.lastname: Köppen
authors.forename: R
authors.initials: R
authors.lastname: Lang
authors.forename: G
authors.initials: G
authors.lastname: Schnorrenberg
mesh_terms: D015119:Aminocaproic Acid; D015394:Molecular Structure; D009478:Neuropeptide Y / Q000031:analogs & derivatives / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011487:Protein Conformation; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter; D015119:Aminocaproic Acid