title: Characteristics of lymphocytes appearing in persistent lymphocytosis induced experimentally in cattle by bovine leukemia virus infection.
abstract: Properties of peripheral blood lymphocytes (PBL) appearing during persistent lymphocytosis (PL) of cattle that was induced by inoculation of a large number of bovine leukemia virus (BLV)-infected lymphocytes were studied. The PBL possessed surface immunoglobulin at a high ratio and had high syncytium-forming activity. The PBL could not be distinguished from normal PBL cytogenetically. These PBL were shown to be polyclonal cells integrating BLV-proviral DNA randomly into their cellular DNA. These properties were similar to those of PBL appearing at the stage of PL of cattle naturally infected with BLV. The BLV-proviral DNA content of PBL and transcription of viral genes increased in parallel with development of PL and decreased along with a decline of PL indicating the possibility that gene expression and activation of BLV play an important role in induction and maintenance of PL.
authors.forename: Y
authors.initials: Y
authors.lastname: Kono
authors.forename: S
authors.initials: S
authors.lastname: Itohara
authors.forename: S
authors.initials: S
authors.lastname: Muramatsu
authors.forename: H
authors.initials: H
authors.lastname: Sentsui
authors.forename: S
authors.initials: S
authors.lastname: Ishino
authors.forename: K
authors.initials: K
authors.lastname: Sekikawa
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000382:microbiology*; D001909:Leukemia Virus, Bovine; D007942:Leukemia, Experimental / Q000097:blood / Q000382:microbiology / Q000662:veterinary*; D008214:Lymphocytes / Q000382:microbiology* / Q000473:pathology; D008218:Lymphocytosis / Q000097:blood / Q000382:microbiology / Q000662:veterinary*