T lymphocyte subset abnormalities and HLA antigens in scleroderma (systemic sclerosis).
Studies of T lymphocyte subsets were carried out in a group of 50 scleroderma patients, of whom 46 were also HLA phenotyped. The total lymphocyte count was depressed in 22 patients, and CD4 (helper cells) numbers were normal. CD8 (suppressor-cytotoxic) cells were reduced in 27 patients, and the CD4/CD8 number ratio increased above normal in three additional patients, resulting in 30 patients being classified as CD8-deficient. In the 46 patients HLA phenotyped, DRw8 was significantly increased in the entire patient group, but when the patients were subdivided into CD8-deficient (n = 29) and CD8-normal (n = 17), the increase in DRw8 was confined to the CD8-deficient patients. B18 was also increased in patients with limited sclerosis, while DR4 and DRw53 were significantly decreased and DR5 significantly increased in patients with more extensive skin sclerosis. These findings suggest that scleroderma is a heterogeneous condition and that this heterogeneity is reflected in different HLA profiles in patients subtyped according to their clinical profile and subpopulations of T cells.
Barnett
A J
AJ
Tissue Typing Laboratory, Royal Melbourne Hospital, Australia.
Tait
B D
BD
Barnett
M A
MA
Toh
B H
BH
D000328:Adult; D000368:Aged; D000483:Alleles; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D006684:HLA-DR Antigens