title: The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion.
abstract: The regulation and function of two forms of the amyloid beta protein precursor (ABPP) that are released into the growth-conditioned medium of the PC12 nerve cell line were examined. Nerve growth factor increases the release of the form of ABPP without the protease-inhibitor domain relative to the protein containing the protease inhibitor and increases the overall rate of ABPP secretion 2-fold. In contrast, fibroblast growth factor increases the rate of ABPP secretion approximately 7-fold. Both forms of the secreted ABPP molecule are, in turn, able to stimulate adhesion of PC12 cells to substrata to which they are adsorbed about 10-fold more efficiently on a molar basis than Iaminin.
authors.affiliation: Salk Institute For Biological Studies, San Diego, California 92138.
authors.forename: D
authors.initials: D
authors.lastname: Schubert
authors.forename: L W
authors.initials: LW
authors.lastname: Jin
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: G
authors.initials: G
authors.lastname: Cole
mesh_terms: D000682:Amyloid / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D002460:Cell Line; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D008970:Molecular Weight; D009414:Nerve Growth Factors / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D011480:Protease Inhibitors; D011498:Protein Precursors / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology
chemical_list: D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D009414:Nerve Growth Factors; D011480:Protease Inhibitors; D011498:Protein Precursors; D005346:Fibroblast Growth Factors