title: Age-related changes in contact photosensitivity differ among mouse strains.
abstract: There are differences among mouse strains in the age-related changes in reactivity to the contact photosensitizer tetrachlorosalicylanilide (TCSA). We found a tendency to lower reactions in older mice, with some strains showing declines from an early age (BALB/cJ, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J). Others had increasing reactions until about 30-50 weeks of age before declining (DBA/1J, C3H/HeJ, and A/J) and one strain (C57BL/6J) had increased reactivity with age. There are also differences in the role of cyclophosphamide-sensitive T-suppressor cells in these age-related changes. In some mouse strains, BALB/cJ, C57BL/6J, A/J, DBA/1J and C3H/HeJ, age-related changes in reactivity to TCSA are independent of changes in cyclophosphamide-sensitive suppressor cells. In other strains, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J, the development of cyclophosphamide-sensitive suppressor cells is responsible for the initial, though not later, stages of the age-related decline in reactivity.
authors.affiliation: Department of Medicine (Division of Dermatology), University of Toronto, Ontario, Canada.
authors.forename: W R
authors.initials: WR
authors.lastname: Brown
authors.forename: G M
authors.initials: GM
authors.lastname: Shivji
authors.forename: R D
authors.initials: RD
authors.lastname: Furukawa
authors.forename: C A
authors.initials: CA
authors.lastname: Ramsay
authors.forename: B
authors.initials: B
authors.lastname: Cinader
mesh_terms: D000375:Aging / Q000502:physiology*; D000485:Allergens; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012457:Salicylamides / Q000494:pharmacology; D012458:Salicylanilides / Q000494:pharmacology; D013045:Species Specificity; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
chemical_list: D000485:Allergens; D012457:Salicylamides; D012458:Salicylanilides; D003520:Cyclophosphamide; C003390:3,3',4',5-tetrachlorosalicylanilide