title: Hormone status in patients with slipped capital femoral epiphysis.
abstract: In 15 consecutive patients with slipped capital femoral epiphysis we recorded height, weight and skeletal maturity. Sexual maturity was assessed clinically and biochemically, and Harris's hypothesis that there is an increased ratio of serum growth hormone to oestrogen was tested in comparison with 15 age and sex matched controls. We found no difference in skeletal or sexual maturity between the groups, or any overt endocrine abnormality in the patients. However almost half the patients with slipped epiphysis were over the 90th weight percentile, suggesting that mechanical factors such as obesity are more important aetiologically than endocrine abnormalities.
authors.affiliation: Department of Orthopaedic Surgery, Leicester Royal Infirmary, England.
authors.forename: I J
authors.initials: IJ
authors.lastname: Brenkel
authors.forename: J J
authors.initials: JJ
authors.lastname: Dias
authors.forename: T G
authors.initials: TG
authors.lastname: Davies
authors.forename: S J
authors.initials: SJ
authors.lastname: Iqbal
authors.forename: P J
authors.initials: PJ
authors.lastname: Gregg
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000738:Androsterone / Q000378:metabolism; D001827:Body Height; D001835:Body Weight; D002648:Child; D003687:Dehydroepiandrosterone / Q000378:metabolism; D004839:Epiphyses, Slipped / Q000378:metabolism* / Q000503:physiopathology; D004958:Estradiol / Q000378:metabolism; D005043:Etiocholanolone / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D012741:Sexual Maturation; D013739:Testosterone / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism
chemical_list: D006728:Hormones; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D005043:Etiocholanolone; D000738:Androsterone; D013974:Thyroxine