Osteosclerotic myeloma with polyneuropathy and hypocalcemia.
A case is presented of a 46-year-old man with multifocal osteosclerotic bone lesions, peripheral polyneuropathy and hypocalcemia. Histologic examination of a bone marrow biopsy disclosed a multiple myeloma. Immunoelectrophoresis revealed a small M-component identified as IgG-lambda. Osteosclerotic myeloma lacking any osteolytic lesions seems to be very rare and shows several different features as compared with classical myeloma. A review of the current literature suggests that multiple myeloma is not a uniform disease but rather a group of clinical syndromes characterized by the special properties of their proliferating plasma cell clones.
Ludescher
C
C
Department of Pathology, University of Innsbruck, Austria.
Grünewald
K
K
Fend
F
F
Dietze
O
O
Thaler
J
J
Schmid
K W
KW
D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D006996:Hypocalcemia / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D010026:Osteosclerosis / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D013577:Syndrome