Movement of microtubules by single kinesin molecules.
Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles along microtubules. Using a new technique for measuring the movement produced in vitro by individual kinesin molecules, it is shown that a single kinesin molecule can move a microtubule for several micrometers. New information about the mechanism of force generation by kinesin is presented.
Howard
J
J
Department of Physiology, University of California School of Medicine, San Francisco.
Hudspeth
A J
AJ
Vale
R D
RD
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002465:Cell Movement; D002474:Cell-Free System; D066298:In Vitro Techniques; D016547:Kinesins; D008868:Microtubule Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D014741:Video Recording
D008868:Microtubule Proteins; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D016547:Kinesins