title: Platelet aggregation and prostaglandin metabolites in the blood of patients with ischaemic heart disease during antiarrhythmic treatment.
abstract: The influence of antiarrhythmic drugs (oral lidocaine, palpitine, Etacizine) on blood platelet aggregation and prostaglandin metabolites was studied in 91 patients with ischaemic heart disease. Lidocaine showed a positive, Etacizine a negative, and palpitine no effect on platelet aggregation. There was no uniform effect of lidocaine on prostaglandin metabolites; it increased the prostacycline and decreased the thromboxane levels. Palpitine increased both prostacyclin and thromboxane levels, whereas Etacizine decreased both metabolites, especially prostacyclin.
authors.affiliation: Institute of Stomatology, Moscow, USSR.
authors.forename: L L
authors.initials: LL
authors.lastname: Kirichenko
authors.forename: V P
authors.initials: VP
authors.lastname: Masenko
authors.forename: V A
authors.initials: VA
authors.lastname: Gorshkov
authors.forename: A K
authors.initials: AK
authors.lastname: Narynski
authors.forename: T I
authors.initials: TI
authors.lastname: Kurakina
authors.forename: L M
authors.initials: LM
authors.lastname: Morozova
authors.forename: V I
authors.initials: VI
authors.lastname: Mamaev
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004206:Disopyramide / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D010640:Phenothiazines / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins / Q000378:metabolism*
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D008012:Lidocaine; C046818:ethacizine; D005996:Nitroglycerin; D004206:Disopyramide