Unique reactions of scrotal skin to topical agents.
Topical agents that do not produce irritant reaction elsewhere on the skin readily produce irritant dermatitis and even ulceration when applied to scrotal skin. As Shelley and Shelley state: "The scrotum must be recognized as a skin area with remarkable permeability. It provides a unique percutaneous doorway for the entrance of drugs into the circulation and is thus uniquely susceptible to toxic and irritant agents."
Fisher
A A
AA
New York University Medical School, New York.
D000279:Administration, Cutaneous; D000328:Adult; D000536:Aluminum Hydroxide / Q000009:adverse effects; D001252:Astringents / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D006204:Hair Removal / Q000009:adverse effects; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D011033:Podophyllin / Q000009:adverse effects; D012611:Scrotum / Q000187:drug effects*; D013864:Thioglycolates / Q000009:adverse effects
D001252:Astringents; D007509:Irritants; D013864:Thioglycolates; C016213:aluminum oxychloride; D000536:Aluminum Hydroxide; C017487:2-mercaptoacetate; D011033:Podophyllin