Simultaneous two-probe laser Doppler velocimetric assessment of topically applied drugs in rats.
A simple, noninvasive method for the determination of cutaneous blood flow in anesthetized rats is presented. Simultaneous two-probe laser doppler velocimetry is shown to be a useful preclinical tool for the assessment of topically applied drugs.
Hirkaler
G M
GM
Department of Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey.
Rosenberger
L B
LB
D000287:Administration, Topical; D000818:Animals; D008297:Male; D008914:Minoxidil / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D012867:Skin / Q000098:blood supply*
D008914:Minoxidil