[Cephalosporins: bacterial resistance measured by penicillin-binding proteins].
Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review.
Garrido
J
J
López
F
F
D000107:Acetylation; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000378:metabolism; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases
D001426:Bacterial Proteins; D002352:Carrier Proteins; D002511:Cephalosporins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase
Cefalosporinas: resistencia bacteriana mediada por PBPs.