Raised plasma levels of atrial natriuretic peptides in Addison's disease.
Plasma levels of atrial natriuretic peptides (ANP) were significantly higher in 7 patients with treated Addison's disease (15.8 +/- 8.8 pg/ml, mean +/- SD) than in 7 control subjects (6.1 +/- 3.8 pg/ml) matched for sex, age, body weight and blood pressure. All subjects were studied on their usual sodium intake and had similar urinary sodium excretions. These findings indicate inappropriately high levels of plasma ANP in patients with treated Addison's disease and are possibly due to the lack of adrenal control on ANP synthesis and/or secretion in these patients.
Cappuccio
F P
FP
Department of Medicine, Charing Cross & Westminster Medical School, London, U.K.
Markandu
N D
ND
Buckley
M G
MG
Sugden
A L
AL
Sagnella
G A
GA
MacGregor
G A
GA
D000224:Addison Disease / Q000097:blood*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000652:urine
D009320:Atrial Natriuretic Factor; D012964:Sodium