Lung injury in rabbits induced by intravenous administration of heterologous polyclonal antibodies to angiotensin converting enzyme (kininase II).
Antibody interactions with the endothelial cell membrane glycoprotein angiotensin converting enzyme (Kininase II) in vivo exhibit features of aggregation and capping with resultant shedding similar to those events described in several in vitro isolated cell systems. Requirements for divalent ligand binding, deposition of complement and participation of cytoskeletal elements are demonstrated in vivo. Persistence of antigen in immune complexes with complement interaction appear to be necessary to induce an inflammatory response. Abrogation of this response occurs when circumstances permit antigenic modulation with removal of the immune complex from the endothelial surface.
Caldwell
P R
PR
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Camussi
G
G
Brentjens
J R
JR
Andres
G
G
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface; D004727:Endothelium / Q000201:enzymology; D008168:Lung / Q000201:enzymology / Q000473:pathology; D055370:Lung Injury; D007703:Peptidyl-Dipeptidase A / Q000276:immunology*; D011817:Rabbits
D000906:Antibodies; D000954:Antigens, Surface; D007703:Peptidyl-Dipeptidase A