Metoclopramide fails to suppress linguopharyngeal events in a rat dyskinesia model.
The effects of metoclopramide on ketamine-induced linguopharyngeal events exemplified by tongue retrusions, protrusions, and swallowing acts were tested in ketamine-anesthetized rats mounted on a stereotaxic frame with the tip of the tongue tied to a force displacement transducer to monitor retrusion and protrusion and a pressure transducer inserted into the mouth at the level of the soft palate to monitor swallowing. Metoclopramide at doses ranging from 0.5 to 50 mg/kg im failed to decrease protrusions, retrusions, or swallowing. It rather increased all three events for up to 2.5 hours. The significance of these findings is discussed.
Marco
L A
LA
Department of Psychiatry, College of Medicine, University of South Alabama, Mobile 36617.
Reed
T F
TF
Joshi
R S
RS
Aldes
L D
LD
Chronister
R B
RB
D000818:Animals; D003679:Deglutition / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D007273:Injections, Intramuscular; D007649:Ketamine; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D014059:Tongue / Q000187:drug effects* / Q000503:physiopathology
D011954:Receptors, Dopamine; D007649:Ketamine; D008787:Metoclopramide