[Immunohistochemical studies in fungal diseases of skin].
The aim of the present work was to characterize the infiltrating cells in fungal diseases of the skin by using immunohistochemical methods. The lesions of superficial mycosis were characterized by a increase in the number of Langerhans cells (OKT6, HLADR+). In the upper dermis more OKT4 cells stained than OKT8, and in the deeper dermis the was a more decreased ratio of OKT4+/OKT8+ cells. On the other hand, the granulomatous reactions of deep mycosis mainly consisted of cells that were labeled positively for lysozyme and alpha 1-antichymotrypsin. In cases with secondary or local immunodeficiency, however, the infiltrating cells wer negative for these enzymes.
Tanuma
H
H
Iwasaki
M
M
Nishiyama
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003881:Dermatomycoses / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007801:Langerhans Cells / Q000032:analysis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000032:analysis / Q000473:pathology