Hypophagia after long-term administration of sulpiride in adult female rats: a model of D2 dopamine receptors supersensitivity?
Sulpiride (20 mg/kg/ip for 21 days) induced in female rats a significant body weight increase and hyperphagia. After drug withdrawal a significant hypophagia was observed. It is hypothesised that this hypophagia might be a spontaneous manifestation of D2 dopamine receptors supersensitivity, either in the perifornical region of the lateral hypothalamus or in the pituitary.
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Laboratorio de Fisiologia de la Conducta, Facultad de Medicina, Universidad de los Andes, Mérida, Venezuela.
D000818:Animals; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D005260:Female; D008954:Models, Biological; D051381:Rats / Q000502:physiology*; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D012727:Sex Characteristics; D013469:Sulpiride / Q000009:adverse effects*; D013997:Time Factors
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013469:Sulpiride