title: Cystosarcoma phyllodes. Effective therapy with cisplatin and etoposide chemotherapy.
abstract: Cystosarcoma phyllodes is an unusual breast neoplasm that rarely metastasizes. Most series report chemotherapy, radiation, and hormonal therapy to be ineffective. Three patients were treated with cisplatin and etoposide combination chemotherapy with effective palliation in two patients. Radiation therapy was effective in controlling symptomatic metastasis in all three patients. Hormonal therapy was ineffective in two patients despite the presence of positive hormone receptors. Chemotherapy and radiotherapy may be more effective in the treatment of this tumor than has been reported, although there is no apparent role for hormonal therapy. Functional hormone receptors are probably not present.
authors.affiliation: Comprehensive Breast Clinic, Duke University Medical Center, Durham, North Carolina.
authors.forename: G V
authors.initials: GV
authors.lastname: Burton
authors.forename: L L
authors.initials: LL
authors.lastname: Hart
authors.forename: G S
authors.initials: GS
authors.lastname: Leight
authors.forename: J D
authors.initials: JD
authors.lastname: Iglehart
authors.forename: K S
authors.initials: KS
authors.lastname: McCarty
authors.forename: E B
authors.initials: EB
authors.lastname: Cox
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D003557:Phyllodes Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy; D011859:Radiography
chemical_list: D005047:Etoposide; D002945:Cisplatin