title: Distribution of juxtaglomerular cells and synthesis and release of renin granules in patients with renal artery stenosis.
abstract: 100 pieces of renal tissue from 4 patients with renal artery stenosis were studied histologically. Juxtaglomerular cells were found not only in the region close to the glomerulus but also in the proximal 2/3 of the afferent arteriole of the glomerulus, but not in the interlobular arterioles. In the cytoplasm of juxtaglomerular cells, three kinds of granules were found: crystalline granules (immature), the round or ovoid granules (mature), and the lobulated granules (fusion). Renin was synthesized in the rough endoplasmic reticulum and packaged in the Golgi complex. Electron microscopic findings suggested that the secretory microvesicles were produced on the surface of Golgi complex. They fused to form primary crystalline granules, which were enlarged by renin supplied by transportation vesicles and finally formed typical crystalline granules. The mature renin granules (round or ovoid) moved toward the periphery of the cytoplasma. Their limiting membranes on the side toward the basement membrane disintegrated and formed microvesicular bodies passing through the periplasm, and the basement membrane and were discharged into the interstitial matrix.
authors.forename: J W
authors.initials: JW
authors.lastname: Chang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: T X
authors.initials: TX
authors.lastname: Ma
authors.forename: K Q
authors.initials: KQ
authors.lastname: Dong
authors.forename: W C
authors.initials: WC
authors.lastname: Wang
authors.forename: S N
authors.initials: SN
authors.lastname: Han
authors.forename: M Y
authors.initials: MY
authors.lastname: Shen
mesh_terms: D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000648:ultrastructure*; D012078:Renal Artery Obstruction / Q000378:metabolism / Q000473:pathology*; D012083:Renin / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D012083:Renin