[Studies on plasma catecholamine and myocardial adrenergic receptors in two strains of rats with different susceptibilities to chronic hypoxia].
Hilltop SD (HT) rats are known to have a high susceptibility to chronic hypoxia, resulting in severe pulmonary hypertension with stronger myocardial contractility as compared to Wistar (W) rats. In our experiments, both HT and W rats were observed at sea level and in a hypobaric chamber simulating an altitude of 5000 m above sea level for 15 days, and plasma catecholamine and myocardial adrenergic receptor levels were determined. The results suggest that the high susceptibility of HT rats is not directly related to the heart itself, while the reactivity of pulmonary vessels needs further investigation.
Liu
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D000531:Altitude; D000818:Animals; D004837:Epinephrine / Q000097:blood*; D006976:Hypertension, Pulmonary / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D013045:Species Specificity
D011941:Receptors, Adrenergic; D009638:Norepinephrine; D004837:Epinephrine