Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Effects of hydroperoxides, autoxidation products of linolic acid (HPO) and secondary oxidative products of HPO (SOP) (5% each in diet) were examined in female Sprague-Dawley rats. HPO and SOP administration was carried out during or subsequent to two injections of dimethylhydrazine (DMH) (40 mg/kg body wt s.c.), and a single i.g. dose of 7,12-dimethylbenz[a]anthracene (DMBA) (50 mg/kg body wt). No significant differences in the incidences of tumors in the mammary gland, colon, ear duct and hematopoietic system associated with HPO or SOP treatment were evident, during or after carcinogen exposure. The present results therefore indicate that the environmental contaminants, HPO and SOP, lack any potential for modification of mammary gland or colon carcinogenesis under the conditions of the investigation.
Hirose
M
M
First Department of Pathology, Nagoya City University Medical School, Japan.
Kurata
Y
Y
Yamada
M
M
Shirai
T
T
Ito
N
N
Ohsawa
T
T
D019813:1,2-Dimethylhydrazine; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004127:Dimethylhydrazines / Q000008:administration & dosage / Q000378:metabolism; D004428:Ear Neoplasms / Q000139:chemically induced*; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D019813:1,2-Dimethylhydrazine