Disseminated cat-scratch disease in a patient with AIDS.
A patient with AIDS developed subcutaneous nodules and associated osteolytic lesions with negative stains and cultures for bacteria, fungi and parasites. Flucloxacillin was not effective but treatment with vancomycin was associated with improvement. Six months later the patient became severely ill, with fever, malaise and multiple skin and laryngeal papules. Cat-scratch disease was diagnosed from the typical epithelioid angiomatosis seen in skin biopsies with bacterium-like structures in the Warthin-Starry stain. Retrospectively these typical structures were also seen in earlier biopsies. All lesions improved after therapy with erythromycin had been instituted.
van der Wouw
P A
PA
Department of Internal Medicine, University of Amsterdam, The Netherlands.
Hadderingh
R J
RJ
Reiss
P
P
Hulsebosch
H J
HJ
Walford
N
N
Lange
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002372:Cat-Scratch Disease / Q000150:complications* / Q000188:drug therapy; D004917:Erythromycin / Q000627:therapeutic use; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D014640:Vancomycin / Q000627:therapeutic use
D005436:Floxacillin; D004917:Erythromycin; D014640:Vancomycin