Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection.
A 10-year-old boy with chronic active Epstein-Barr virus (EBV) infection developed T-cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3+, CD4+ and HLA-DR+. The genomic DNAs from these cells demonstrated two rearranged T-cell receptor beta-chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T-cell lymphoproliferation.
Ishihara
S
S
Department of Pediatrics, Osaka University Hospital.
Tawa
A
A
Yumura-Yagi
K
K
Murata
M
M
Hara
J
J
Yabuuchi
H
H
Hirai
K
K
Kawa-Ha
K
K
D015139:Blotting, Southern; D002648:Child; D002908:Chronic Disease; D002999:Clone Cells; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D006566:Herpesviridae Infections / Q000382:microbiology*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000382:microbiology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology*
D015342:DNA Probes; D004279:DNA, Viral