Heterophile IgM, IgA, and IgE antibodies in infectious mononucleosis.
Fifty infectious mononucleosis (IM) and 150 non-infectious mononucleosis (non-IM) sera were tested by a hemadsorption immunocapture test (HIT) for the detection of heterophile antibodies of IgM, IgA, and IgE classes. The specificity of Paul-Bunnell (PB) antibodies was ascertained by a differential absorption test. IgM PB-antibodies were demonstrated in 100% of IM sera, IgA in 92%, and IgE in 88%. PB antibodies were present only in IM sera; but other heterophile antibodies of IgM (68%), IgA (6.7%), and IgE (9.3%) classes were demonstrated in non-IM sera. IgA and IgE heterophile antibodies were thus present, especially in IM sera. HIT was found to be more sensitive than Paul-Bunnell Davidsohn test (PBD test) and suitable for the diagnosis of infectious mononucleosis.
Duverlie
G
G
Laboratoire de Virologie, Centre Hospitalier Universitaire, Amiens, France.
Driencourt
M
M
Roussel
C
C
Orfila
J
J
D000910:Antibodies, Heterophile / Q000032:analysis* / Q000276:immunology; D000918:Antibody Specificity; D006382:Hemadsorption; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis / Q000276:immunology*; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology; D012698:Serologic Tests
D000910:Antibodies, Heterophile; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007073:Immunoglobulin E