[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy].
The radioligand-receptor method was used to assay the M-cholinereceptors and opioid binding centers in biopsy specimens of the duodenal mucosa from 40 patients with duodenal ulcer as compared with the results of subsequent therapy by means of gastrocepin (20 patients) and dalargin (20 patients). Analysis of the isothermal curve of 3H-QNB-binding with duodenal mucosa membranes within Skatchard's coordinates showed the presence of 2 subtypes of muscarinic receptors blocked (M1) and not blocked (M2) by gastrocepin. The majority of the patients in both groups demonstrated a significant decrease of the dissociation constant as compared to the control (20 patients). In patients with high receptor sensitivity to gastrocepin and dalargin, ulcer cicatrization was noted during the treatment in all the cases. Meanwhile the treatment proved little effective in patients with appreciably decreased receptor sensitivity to the drugs under consideration. The data obtained indicate the possibility of predicting the results of duodenal ulcer treatment by means of the radioreceptor analysis, providing the basis for the individualized treatment choice.
Pavlov
S A
SA
Vinogradov
V A
VA
Iarygin
K N
KN
Shugurov
V A
VA
Bogdanov
A N
AN
D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004386:Duodenum / Q000032:analysis / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000627:therapeutic use*; D011869:Radioligand Assay; D011976:Receptors, Muscarinic / Q000032:analysis / Q000187:drug effects*; D011957:Receptors, Opioid / Q000032:analysis / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D011976:Receptors, Muscarinic; D011957:Receptors, Opioid; D010890:Pirenzepine; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Retseptornaia kharakteristika duodenal'noĭ slizistoi pri iazvennoĭ bolezni: novyĭ podkhod k individualizirovannomu vyboru terapii.