Platelet-derived growth factor (PDGF) in type 1 diabetes mellitus.
In 10 patients with type 1 diabetes mellitus, platelet-derived growth factor (PDGF) was assessed using an in vitro assay based on the stimulation of DNA synthesis in the 3T3 mouse fibroblast cell line. beta-Thromboglobulin (beta-TG) was used as an index for platelet alpha-granules content. Platelet beta-TG content and PDGF were markedly decreased in diabetic patients while plasma beta-TG was increased as compared with control subjects. In diabetic patients, a significant negative correlation was found between plasma beta-TG level and beta-TG total platelet content, associated with a significant positive correlation between platelet beta-TG content and PDGF. These results suggest that PDGF release might be increased in diabetic subjects. This may account in part for the cell proliferation observed in diabetic angiopathy.
Guillausseau
P J
PJ
Department of Diabetology, Hôpital Lariboisiere, Paris, France.
Dupuy
E
E
Bryckaert
M C
MC
Timsit
J
J
Chanson
P
P
Tobelem
G
G
Caen
J P
JP
Lubetzki
J
J
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000097:blood*; D001620:beta-Thromboglobulin / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D001620:beta-Thromboglobulin