title: Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus.
abstract: By using amino acid sequence patterns (motifs) diagnostic of conserved regions within the catalytic domains of protein kinases, homologous open reading frames of three herpesviruses were identified as protein kinase-related genes. The three sequences, herpes simplex virus gene UL13, varicella-zoster virus gene 47, and Epstein-Barr virus gene BGLF4, resemble serine/threonine kinases rather than tyrosine kinases.
authors.affiliation: Molecular Biology Computer Research Resource, Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: R F
authors.initials: RF
authors.lastname: Smith
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D005814:Genes, Viral; D014645:Herpesvirus 3, Human / Q000201:enzymology / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics*
chemical_list: D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases