[Nodular hyperthyroidism: surgical experience and hypothesis of carcinogenic correlations].
In a retrospective study 109 patients operated for nodular toxic goiter from 1984 to may 1988 are examined. Clinical feature, diagnosis and surgical approach are analyzed; the follow-up of the patients is reported as well. Some results are really interesting: 1) the incidence of hyperthyroidism in a nodular goiter (toxic multinodular goiter, solitary or multiple Plummer's nodes) is higher in the females; 2) most of the patients with solitary or multiple nodes are middle-young-aged; 3) prevalence of autonomous toxic adenomas; 4) relapses are higher (76%) in young patients with thyroid nodes operated with lobectomy and isthmectomy in pre-toxic stage (multifocality of the disease). Basedowified goiter, on the contrary, is present in old females with a long history of goiter. In these cases, subtotal thyroidectomy is often curative. The association with cancer is a fearful event to remember.
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D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000328:Adult; D005260:Female; D006044:Goiter, Nodular / Q000209:etiology* / Q000601:surgery; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D013964:Thyroid Neoplasms / Q000150:complications* / Q000601:surgery
Ipertiroidismo nodulare: esperienze chirurgiche ed ipotesi di correlazioni oncogenetiche.