Investigation of genetic markers in patients with Crohn's disease and ulcerative colitis.
Inflammatory bowel diseases (IBD) as Crohn's disease (CD) and ulcerative colitis (UC) are believed to have a genetic basis. Additional factors are supposed to promote the development of IBD. However, apart from a few reports of HLA associations which await confirmation by other groups strong associations to (a) particular genetic marker(s) are still lacking. We here report on previously unobserved associations of CD to MNSS and UC to the immunoglobulin heavy chain allotype Gm 1,-2,10. We suggest that these factors play a role in a wider spectrum of genetic markers for the development of IBD.
Purrmann
J
J
Department of Gastroenterology, University of Düsseldorf, F.R.G.
Bertrams
J
J
Knapp
M
M
Cleveland
S
S
Gemsa
R
R
Hengels
K J
KJ
Strohmeyer
G
G
D000135:Acid Phosphatase / Q000235:genetics; D000243:Adenosine Deaminase / Q000235:genetics; D000263:Adenylate Kinase / Q000235:genetics; D000410:Alanine Transaminase / Q000235:genetics; D001789:Blood Group Antigens / Q000235:genetics; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D004912:Erythrocytes / Q000201:enzymology; D005819:Genetic Markers; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics; D011110:Polymorphism, Genetic
D001789:Blood Group Antigens; D005819:Genetic Markers; D007129:Immunoglobulin Gm Allotypes; D010734:Phosphogluconate Dehydrogenase; D000410:Alanine Transaminase; D000263:Adenylate Kinase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; C020118:ESD protein, human; D000135:Acid Phosphatase; D000243:Adenosine Deaminase; D010733:Phosphoglucomutase