The effect of chronic gonadotropin-releasing hormone analog (D-Trp-6) treatment on elevated and normal serum prolactin levels.
A long-acting GnRHa (D-Trp-6 microcapsules) proved capable of lowering serum PRL levels in a young hyperprolactinemic patient treated for a large myomatous uterus. No similar inhibitory effect was found in normoprolactinemia. Chronic GnRHa therapy may constitute an alternative to the existing forms of treatment for hyperprolactinemia and pituitary adenomas.
Golan
A
A
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel.
Bukovsky
I
I
Weinraub
Z
Z
Ron-El
R
R
Herman
A
A
Raziel
A
A
Caspi
E
E
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000188:drug therapy*; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy*; D017329:Triptorelin Pamoate; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy*
D000970:Antineoplastic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone