Preventing effect of "liuwei dihuang decoction" on esophageal carcinoma.
Liuwei Dihuang Decoction is a representative classic prescription for nourishing Yin in Traditional Chinese Medicine. Experimental and clinical studies showed that the recipe could 1. inhibit carcinogenesis of anterior stomach by N-nitrososarcosine ethyl ester in mice; 2. inhibit the formation of lung tumors induced by Urethan in mice; 3. decrease spontaneous tumorigenesis in LACA strain; 4. inhibit the mutagenic activity of Endoxan in micronuclear test. Patients with epithelial dysplasia of esophagus, a preneoplastic lesion, were treated by using this recipe. The canceration rate within 1 year was 2.2% in the treated and 12.4% in an untreated group. Within 5 years these rates were 9% and 26% respectively (p less than 0.025).
Jiang
T L
TL
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Yan
S C
SC
Zhao
L F
LF
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology; D000242:Cyclic AMP / Q000096:biosynthesis; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D009602:Nitrosamines; D010587:Phagocytosis / Q000187:drug effects; D011230:Precancerous Conditions / Q000188:drug therapy / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology; D014520:Urethane; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality
D004365:Drugs, Chinese Herbal; D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; D014520:Urethane; D003520:Cyclophosphamide; D000242:Cyclic AMP