An experimental study of the impact of cancer on nitrogen metabolism and wound healing.
In Wistar rats bearing a Walker-256 carcinoma flank tumor, a standard skin wound was inflicted on the backs of the animals. Nitrogen intake and nitrogen balance measures were obtained. The standard wound did not promote tumor growth. Wound contraction in tumor-bearing animals was not different from that in tumor-free animals. Tumor-bearing rats had anorexia, lower nitrogen intake and a tendency to lower their nitrogen balance. These findings suggest that both cancer and wound healing are privileged metabolic events, having as a consequence sacrifice of the host.
Gonçalves
E L
EL
Department of Surgery, University of São Paulo Medical School, Brazil.
Waitzberg
D L
DL
Bevilacqua
L R
LR
Bevilacqua
R G
RG
Margarido
N F
NF
Goffi
F S
FS
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D002921:Cicatrix / Q000209:etiology / Q000378:metabolism; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000502:physiology*
D009584:Nitrogen