title: Transient post-partum thyroid dysfunction and postnatal depression.
abstract: In the course of a population study of thyroid dysfunction in pregnancy and the post-partum period, 65 women, considered to be antibody-positive (microsomal and thyroglobulin), and 82 antibody-negative women were assessed for postnatal depression at 6-8 weeks post partum. The women were also assessed for the development of post-partum thyroid dysfunction. Of the 147 women, 22 met DSM-III criteria for major depression. The presence of autoantibodies showed little association with depressed mood but there was a minor association of postnatal depression with actual thyroid dysfunction in that incidence of the latter condition was higher in depressed women (Raskin scale P less than 0.01; Edinburgh scale P less than 0.05; Montgomery-Asberg scale P less than 0.1). Three of eight mothers with thyroid dysfunction had major depression and were depressed on all three scales.
authors.affiliation: University of Wales College of Medicine, Cardiff, U.K.
authors.forename: B
authors.initials: B
authors.lastname: Harris
authors.forename: H
authors.initials: H
authors.lastname: Fung
authors.forename: S
authors.initials: S
authors.lastname: Johns
authors.forename: M
authors.initials: M
authors.lastname: Kologlu
authors.forename: R
authors.initials: R
authors.lastname: Bhatti
authors.forename: A M
authors.initials: AM
authors.lastname: McGregor
authors.forename: C J
authors.initials: CJ
authors.lastname: Richards
authors.forename: R
authors.initials: R
authors.lastname: Hall
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D019965:Neurocognitive Disorders / Q000503:physiopathology* / Q000523:psychology; D011247:Pregnancy; D011569:Psychiatric Status Rating Scales; D011644:Puerperal Disorders / Q000503:physiopathology* / Q000523:psychology; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin