title: Providing vitamin D to confined sheep by oral supplementation vs ultraviolet irradiation.
abstract: Serial vitamin D3 (D3) and 25-hydroxyvitamin D3 (25 OH D3) concentrations of plasma were measured in confined, shorn sheep that had either been supplemented with vitamin D3 (50 micrograms/d) or exposed daily to ultraviolet irradiation (UVI). In the sheep administered D3 orally, plasma D3 increased continuously until d 35. This was followed by small fluctuations of the plasma D3 concentrations until a plateau was reached after 56 d of supplementation (.94 ng/ml plasma). Plasma 25 OH D3 concentrations increased continuously and plateaued between d 65 to 75 at about 21 ng/ml plasma. In the UVI sheep, plasma D3 and 25 OH D3 concentrations increased continuously for the first 49 d, then plateaued at 2.03 ng D3 and 29.6 ng 25 OH D3/ml. When a plateau was reached in plasma 25 OH D3 concentrations in both treatment groups, a 3H-labeled tracer dose of 25 OH D3 was given i.v., and disappearance of the 3H-labeled 25 OH D3 was followed. The UVI group had a faster decline in specific activities during the first exponential phase but a slower decline during the prolonged terminal elimination phase. These differences are reflected in the intercompartmental transfer rates. Our data indicate that UVI is as effective as oral vitamin D3 supplementation for improving vitamin D status of confined sheep.
authors.affiliation: Agriculture Canada, Ottawa, Ontario.
authors.forename: M
authors.initials: M
authors.lastname: Hidiroglou
authors.forename: K
authors.initials: K
authors.lastname: Karpinski
mesh_terms: D000818:Animals; D002112:Calcifediol / Q000097:blood; D002762:Cholecalciferol / Q000097:blood; D008297:Male; D011897:Random Allocation; D012756:Sheep / Q000097:blood / Q000378:metabolism*; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood
chemical_list: D014807:Vitamin D; D002762:Cholecalciferol; D002112:Calcifediol