Age differences between distributions of genotypes among pregnant women: evidence of fertility selection.
The number of children produced by a modern woman is usually below her total reproductive capacity and is determined by circumstances other than natural selection. It is, therefore, practically impossible to detect differences in natural fertilities associated with different types (e.g. phenotypes, genotypes) of women. This does not mean, however, that natural selection at the reproductive level cannot at all be detected today. If women of a particular type have high natural fertility, this usually means that they reproduce (become pregnant) at a higher rate than women of a type with lower natural fertility. Hence, when there is a limit on the number of children, women of the first type will reach the limit at an earlier age than women of the second type. As a result, types that have a higher natural fertility should be overrepresented among pregnant women of younger ages and, consequently, underrepresented among older ones, as compared to types with a lower natural fertility. Based on this notion, a model of age-related differences between distributions of types among pregnant women is suggested. The model is applied to data on MNSs-blood group and PGM1 (phosphoglucomutase) types in a sample of pregnant women and an evidence of natural selection at the reproduction level associated with these genetic markers is obtained.
Gimelfarb
A
A
Bottini
E
E
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D005298:Fertility; D005838:Genotype; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics; D008957:Models, Genetic; D010733:Phosphoglucomutase / Q000235:genetics; D011247:Pregnancy; D012641:Selection, Genetic
D008951:MNSs Blood-Group System; D010733:Phosphoglucomutase