Sensorineural hearing loss in antigen-induced otitis media.
Chinchillas were sensitized with human serum albumin (HSA). When circulating antibody-titers were sufficiently elevated as to induce local inflammation, 1 ml of HSA (50, 5, 0.5 mg/ml) was instilled into the left middle ear cavity from the superior bulla. HSA containing a steroid agent was instilled into the right ear. Non-sensitized animals were used as control. In the sensitized animals, a significant hearing loss occurred at higher frequencies. The loss was dose-related. Less severe hearing loss was found following steroid treatment. We conclude that sensorineural hearing loss can occur in antigen-induced otitis media.
Morizono
T
T
Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
Hamaguchi
Y
Y
Juhn
S K
SK
D000818:Animals; D001183:Arthus Reaction / Q000276:immunology; D002682:Chinchilla; D003051:Cochlea / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D010033:Otitis Media / Q000150:complications* / Q000209:etiology; D012709:Serum Albumin / Q000276:immunology
D012709:Serum Albumin