Isoniazid acetylation and polymorphism in humans.
Phenotypes of slow and fast acetylators of isoniazid (INH) were determined in 157 subjects (80 normals and 77 patients with tuberculosis) from the twin cities of Rawalpindi and Islamabad. Plasma INH concentrations were determined chemically six hours after the drug ingestion. The findings indicate that 31.8% subjects were fast acetylators of the drug.
Saleem
M
M
Malik
S A
SA
Ahmed
M
M
Saleem
N
N
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000235:genetics
D000123:Acetyltransferases; C025814:isoniazid-transacetylase; D007538:Isoniazid