Brain natriuretic peptides: differential localization of a new family of neuropeptides.
Brain natriuretic peptide (BNP) is a recently discovered neuropeptide, isolated from the porcine brain, that is highly homologous to atriopeptin (AP), the atrial natriuretic peptide. We used a set of highly selective antisera against the two peptides to map their differential distribution immunohistochemically in the rat central nervous system. BNP immunoreactivity has a distinct distribution, involving many central autonomic and endocrine control structures that contain little if any AP immunoreactivity. AP and BNP belong to a family of neuropeptides that may be important in central cardiovascular control.
Saper
C B
CB
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637.
Hurley
K M
KM
Moga
M M
MM
Holmes
H R
HR
Adams
S A
SA
Leahy
K M
KM
Needleman
P
P
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor