Absorption of amlodipine unaffected by food. Solid dose equivalent to solution dose.
The oral bioavailability of amlodipine in healthy volunteers was compared in two separate studies after solution and capsule doses, and after capsule doses in fed and fasting states. The bioavailability of amlodipine was equivalent both in terms of rate and in extent of absorption between solution and capsule doses and in the fed and fasting states.
Faulkner
J K
JK
Department of Clinical Research, Pfizer Central Research, Sandwich, UK.
Hayden
M L
ML
Chasseaud
L F
LF
Taylor
T
T
D000328:Adult; D017311:Amlodipine; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002214:Capsules; D005502:Food; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D012996:Solutions
D002121:Calcium Channel Blockers; D002214:Capsules; D012996:Solutions; D017311:Amlodipine; D009543:Nifedipine