Antitumor activity of calcium in combination with antitumor agents against Lewis lung carcinoma.
The antitumor activity of calcium gluconate in combination with mitomycin C and 5-fluorouracil was examined against subcutaneously implanted Lewis lung carcinoma-bearing C57BL/6 mice. The mice were divided into four groups: group 1 received mitomycin C (2 mg/kg) and 5-fluorouracil (50 mg/kg) intraperitoneally once a week for four weeks beginning from the day after implantation of tumors, as well as calcium gluconate (155 mg/kg) twice a week for the same four weeks; group 2 received only mitomycin C and 5-fluorouracil; group 3 received only calcium gluconate; group 4 received a vehicle (physiological saline). Significantly enhanced inhibition of tumor growth was observed neither in a comparison between groups 3 and 4, nor in a comparison between groups 1 and 2 (expect on day 20 post implantation). Thus calcium gluconate given alone or in combination with antitumor agents hardly appeared to possess effective antitumor activity.
Nakano
K
K
Shizuoka Sena Hospital, Japan.
Fujimoto
S
S
Tokita
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002125:Calcium Gluconate / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D016685:Mitomycin; D002125:Calcium Gluconate; D005472:Fluorouracil