Immunohistochemical localization of alpha-lactalbumin in human breast cancer tissue.
One hundred and eleven formalin-fixed breast cancer tissue samples were examined for the presence of alpha-lactalbumin using our polyclonal antibodies to this specific milk protein. Alpha-lactalbumin was shown to be present in 67 tumor samples (60%), in 15% of cases the occurrence of alpha-lactalbumin was questionable. No relationship was found between alpha-lactalbumin positivity and the histological type of the tumor, differentiation grading, type of invasivity, or stromal reactivity. Disease progression occurred in an equal number of patients with tumors either alpha-lactalbumin positive or negative. However, negativity was often connected with a disease-free interval shorter than 24 months after primary operation.
Simícková
M
M
Research Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.
Lang
B A
BA
Rejthar
A
A
Cernoch
M
M
Sakalová
J
J
Pacovský
Z
Z
D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007768:Lactalbumin / Q000032:analysis*; D008207:Lymphatic Metastasis; D008593:Menopause; D009361:Neoplasm Invasiveness
D007768:Lactalbumin