title: Stereochemical studies on the formation of melanin by monophenol monooxygenase.
abstract: The oxidation of tyrosine by monophenol monooxygenase (tyrosinase: EC 1.10.3.1) to melanin has been studied by a combination of ultraviolet, circular dichroism, and nuclear magnetic resonance techniques. It is demonstrated that the chiral intermediate (dopachrome) is generated stereoselectively in this enzymic reaction.
authors.forename: M
authors.initials: M
authors.lastname: Kajiwara
authors.forename: K
authors.initials: K
authors.lastname: Kurumaya
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: A T
authors.initials: AT
authors.lastname: Carpenter
mesh_terms: D004156:Catechol Oxidase / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000096:biosynthesis*; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008543:Melanins; D004156:Catechol Oxidase