title: [von Willebrand's disease and coronary atherosclerosis. Apropos of 3 cases].
abstract: The von Willebrand factor (VWF) is a link in the platelet-vessel wall interaction which plays an essential role in the response of the vessel wall to an atherosclerosis-including aggression. However, can von Willebrand's disease really prevent the development of atherosclerosis? The authors report 3 cases of young men aged 36, 40 and 51 years with atherogenic risk factors and von Willebrand's disease (two mild and one severe form). The three patients developed both atherosclerotic lesions and thrombosis. This would suggest that VWF deficiency does not protect humans from atherosclerosis.
authors.affiliation: Hôpital cardiologique, Pessac.
authors.forename: M N
authors.initials: MN
authors.lastname: Dulhoste
authors.forename: J
authors.initials: J
authors.lastname: Bonnet
authors.forename: C
authors.initials: C
authors.lastname: Vergnes
authors.forename: A
authors.initials: A
authors.lastname: Choussat
authors.forename: H
authors.initials: H
authors.lastname: Bricaud
mesh_terms: D000328:Adult; D000818:Animals; D001780:Blood Coagulation Tests; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications; D003327:Coronary Disease / Q000097:blood / Q000150:complications*; D003328:Coronary Thrombosis / Q000097:blood / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010973:Platelet Adhesiveness; D013552:Swine; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor
vernacular_title: Maladie de Willebrand et athérosclérose coronarienne. A propos de trois cas.