Transcription activation by the adenovirus E1a protein.
The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.
Lillie
J W
JW
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Green
M R
MR
D000256:Adenoviridae / Q000235:genetics*; D017456:Adenovirus Early Proteins; D002472:Cell Transformation, Viral; D004268:DNA-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D005814:Genes, Viral; D008957:Models, Genetic; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D017456:Adenovirus Early Proteins; D004268:DNA-Binding Proteins; D009856:Oncogene Proteins, Viral