Effect of sizofilan, an immunomodulator, on hepatic microsomal mixed-function oxidase activities in rats.
Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.
Yomogida
S
S
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Koiwai
K
K
Shiba
Y
Y
Ishikawa
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors; D000814:Aniline Compounds / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000037:antagonists & inhibitors; D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D065607:Cytochrome P-450 Enzyme Inhibitors; D006025:Glycosaminoglycans / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012566:Sizofiran / Q000494:pharmacology*
D000814:Aniline Compounds; D065607:Cytochrome P-450 Enzyme Inhibitors; D006025:Glycosaminoglycans; D007166:Immunosuppressive Agents; D012566:Sizofiran; D006899:Mixed Function Oxygenases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D000983:Antipyrine