[The therapeutic procedure at the 1st stage of the combined therapy of patients with small-cell ling cancer].
General principles of management of localized small-cell lung cancer were developed using the experience of treatment of 300 cases of the disease. Tumor extent should be assessed according to the TNM classification. The effectiveness of surgery + radiation as a first component of complex treatment was evaluated in a randomized study which included 71 patients. Patients with T1-3 primary tumor and metastatic involvement of bronchopulmonary lymph nodes, those of the lung root and a group of tracheobronchial lymph nodes (NI-2) should be radically treated with either surgery or radiation. Unless contraindicated, surgery should be preferred at the first stage. However, treatment should start with irradiation in cases of lymph node involvement. The second stage should include combination chemotherapy.
Boĭko
A V
AV
Trakhtenberg
A Kh
AKh
Kiseleva
E S
ES
Frank
G A
GA
Zvekotkina
L S
LS
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011879:Radiotherapy Dosage; D011897:Random Allocation; D013997:Time Factors
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