[The biphasic selective effect of an antiserum to beta-endorphin on pain sensitivity in rats].
In rats beta-endorphin antiserum systemic injection decreased during 1-2 days the threshold of tail-shock and latency of tail-flick tests, and during subsequent 85 days increased the threshold of tail shock, but not changed the latency of tail-flick tests. Naloxone injection blocked the increasing of thresholds, but not changed the latency of tail tests. It is suggested that antiserum evokes the first inhibition and the second selective activation of endogenous antinociceptive opioid system with affinity to electric nociception.
Litvinova
S V
SV
Aristova
V V
VV
Aristov
Iu N
IuN
Shul'govskiĭ
V V
VV
Kaliuzhnyĭ
L V
LV
D000818:Animals; D004558:Electric Stimulation; D006358:Hot Temperature / Q000009:adverse effects; D007106:Immune Sera / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D001615:beta-Endorphin / Q000276:immunology* / Q000502:physiology
D007106:Immune Sera; D009270:Naloxone; D001615:beta-Endorphin
Dvukhfaznyĭ selektivnyĭ éffekt antisyvorotki k beta-éndorfinu na bolevuiu chuvstvitel'nost' u krys.