Role of MHC, Mls and TCR in immune tolerance.
MHC class II molecules and self antigens, such as Mls, influence T-cell selection by clonal deletion of potentially self-reactive T cells. In order to examine the role of various class II molecules in the T-cell receptor-self antigen interaction, class II transgenic and recombinant mice were analysed for TCR expression. Our studies indicate that the A alpha and E alpha chains can present Mls gene products for the clonal deletion of V beta 6-bearing T cells, and that the A alpha q chain is defective in this process. We have also shown that E alpha A beta heterodimer in transgenic and recombinant mice is expressed and functions to delete I-E reactive V beta llT cells, demonstrating again the role of the E alpha molecule.
Anderson
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Department of Immunology, Mayo Clinic, Rochester, MN 55905.
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D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D005434:Flow Cytometry; D006183:H-2 Antigens / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D007108:Immune Tolerance / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*
D000954:Antigens, Surface; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell