title: Epidural administration of morphine for control of cancer pain: long-term efficacy and complications.
abstract: The long-term analgesic effects and the complications of epidural narcotic analgesia (ENA) were investigated in 40 cancer patients in whom systemic narcotic therapy failed to relieve pain or caused unacceptable side effects. In 32 patients, an externally fixated polyamide epidural catheter was used ("external group"), and in 8 patients, a polyurethane epidural catheter was tunneled and connected to a subcutaneous access port ("internal group"). The average duration of catheter treatment was 80.9 days (range 9-533 days). Twenty-five patients were treated as outpatients, and 15 remained hospitalized. Initially, all patients had significant or complete pain relief from 10 mg morphine/day, but the daily epidural morphine requirement showed a threefold increase during the first 3 weeks. During ENA, other methods of pain relief (radiotherapy, chemotherapy, surgery, epidural administration of local anesthetics, and nerve blocks) were necessary in 14 patients. Pharmacological side effects were of minor importance, with transient pruritus being the main subjective complaint. In the "external" group, 31 catheter replacements were necessary, mostly due to backflow of injected morphine outside the catheter. In two patients of the internal group, neurological complications occurred, but these disappeared spontaneously after removal of the system. They were presumably due to epidural fibrosis with compression of the spinal cord. Further technical improvements are necessary for the easier use and higher safety of the catheter technique.
authors.affiliation: Department of Anaesthesiology, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Driessen
authors.forename: P H
authors.initials: PH
authors.lastname: de Mulder
authors.forename: J J
authors.initials: JJ
authors.lastname: Claessen
authors.forename: D
authors.initials: D
authors.lastname: van Diejen
authors.forename: T
authors.initials: T
authors.lastname: Wobbes
mesh_terms: D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D002404:Catheterization; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D009020:Morphine