[The effect of chondroitin sulfate preparations on wound healing and the strength of the surgical scar].
An experimental investigation of the ability of the chondroitinsulphate preparation produced from cattle tracheas, of rumalon and chonsuride to stimulate the regeneration of cutaneous coverings in case of their injury was carried out. A strength of the surgical cicatrix and its elongation at rupture in two weeks' injections of chondroitinsulphate increased in comparison with control. A stimulating effect of chondroitinsulphate to regeneration of flesh wound in case of local single action didn't differ essentially from the effect of chonsuride. In case of application of the preparations, an area of wound for the rats received chondroitinsulphate was already on the eighth day twice as less in comparison with the animals treated with chonsuride. Thus, a stimulating effect of chondroitinsulphate preparation to the regeneration of damaged cutaneous coverings by both parenteral and local administration was shown.
Fialkova
M A
MA
Smirnova
T Iu
TIu
Ivanova
G I
GI
Aboiants
R K
RK
Golubeva
V F
VF
D000818:Animals; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D002921:Cicatrix / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D014020:Tissue Extracts; C000562:Rumalon; D002807:Chondroitin; D002809:Chondroitin Sulfates
Vliianie preparatov khondroitinsul'fata na zazhivlenie ran i prochnost' khirurgicheskogo rubtsa.