[Synthesis and in vivo antitumor effect of N,N-di(2-chlorethyl) hydrazides of natural alpha-aminocarboxylic acids].
N,N-Di(2-chlorethyl)hydrazides of the following alpha-amino-carboxylic acids were synthesized: glycine, valine, norvaline, lysine, phenylalanine, tyrosine, cystine, homocystine, aspartic and glutamic acid as well as the N,N-diethylhydrazides of glycine, phenylalanine and cystine. The N,N-di-(2-chlorethyl)hydrazides have a pronounced effect on solid tumours (tumour growth inhibition by 30-100%), whereas their inhibition activity with ascite tumours is negligible. N,N-diethylhydrazides show analogous but less expressed biological effect.
Zakhariev
S
S
Institut für Molekularbiologie der Bulgarischen Akademie der Wissenschaften und Chemisch-technologische Hochschule, Sofia, VR Bulgarien.
Stoev
S
S
Aleksiev
B
B
Maneva
L
L
Golovinsky
E
E
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000970:Antineoplastic Agents; D006834:Hydrazines; D009588:Nitrogen Mustard Compounds
Synthese und geschwulsthemmende Wirkung in vivo von N,N-Di(2-chlorethyl)hydraziden natürlicher alpha-Aminocarbonsäuren.