Sympathoadrenal responses during bradycardia-hypotension associated with combined infusion of atrial natriuretic factor and prostaglandin E2.
The adrenergic response to an episode of bradycardia and hypotension associated with atrial natriuretic factor and prostaglandin infusion in a healthy male subject is described. Noradrenaline levels did not change despite a profound fall in blood pressure. In contrast, there was an almost thirty-fold increase in adrenaline levels. This dissociated sympathoadrenal response suggests activation of the Bezold-Jarisch reflex.
McMurray
J
J
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
Struthers
A D
AD
D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D001919:Bradycardia / Q000150:complications* / Q000503:physiopathology; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
D009320:Atrial Natriuretic Factor; D012083:Renin; D015232:Dinoprostone; D009638:Norepinephrine; D004837:Epinephrine