Plasma alpha 2-plasmin inhibitor-plasmin complex and FDP-D-Dimer in fulminant hepatic failure.
Plasma levels of alpha 2-plasmin inhibitor-plasmin complex (PI-Pm) and FDP-D-Dimer (FDP-D), one of cross-linked fibrin degradation products, were determined at 42 points in time in 8 patients with fulminant hepatic failure. PI-Pm was abnormally increased at all 25 points when intractable bleeding was present, whereas FDP-D was increased only at 5 of these points. Of 17 points unassociated with such bleeding, both PI-Pm and FDP-D were increased at 3 points; increased PI-Pm alone was found at 1 point measured next day after the bleeding ceased; and increased FDP-D alone were at 5 points when ascites, one of common complications of fulminant hepatic failure, developed. When PI-Pm was increased, plasma levels of fibrin/fibrinogen degradation products (FDP) changed together with FDP-D.
Tomiya
T
T
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Hayashi
S
S
Ogata
I
I
Fujiwara
K
K
D000328:Adult; D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006470:Hemorrhage / Q000097:blood / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; D005341:Fibrinolysin