Renal effects of atrial natriuretic factor (99-126) in potassium loaded sheep.
1. The renal response to renal arterial infusion of synthetic atrial natriuretic factor (ANF 99-126) was examined in conscious sheep following dietary K loading, and compared with the response in normal sheep. 2. Renal arterial infusion of ANF in K loaded sheep increased the excretion of Na and Ca, but did not affect the excretion of K. 3. The natriuretic effect of ANF was attenuated in K loaded animals, possibly as a consequence of the reduction in Na status which is associated with K loading.
Yates
N A
NA
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Coghlan
J P
JP
Scoggins
B A
BA
McDougall
J G
JG
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D005260:Female; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000187:drug effects*; D009318:Natriuresis / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology* / Q000652:urine; D012756:Sheep
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; D011188:Potassium