title: Vascular damage, fibrosis, and chronic inflammation in mechanical back pain problems.
abstract: Our current hypothesis is that mechanical damage in the spine such as a disc prolapse can lead directly to pain. However, pain arising for this reason is usually of short duration. In many subjects, however, the mechanical problems lead to vascular damage and, in particular, venous obstruction and dilatation with endothelial damage, fibrin deposition, and intravascular thromboses. In turn, this is associated with perineural and intraneural fibrosis. There is a defect in the fibrinolytic system in the peripheral blood that may be the result of vascular damage but in turn may contribute to the persistence of this problem. Therefore, it seems likely that in many patients with chronic mechanical back pain there are important vascular, fibrotic, and inflammatory components to the problem. Treatment in the future should be directed specifically at these aspects of the disorder and hopefully can lead to better control of symptoms.
authors.affiliation: Rheumatic Diseases Centre, University of Manchester, Hope Hospital Salford, England.
authors.forename: M I
authors.initials: MI
authors.lastname: Jayson
mesh_terms: D001100:Arachnoiditis / Q000150:complications* / Q000473:pathology; D001416:Back Pain / Q000209:etiology*; D001696:Biomechanical Phenomena; D005337:Fibrin / Q000378:metabolism; D005355:Fibrosis / Q000150:complications*; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D013128:Spinal Osteophytosis / Q000150:complications / Q000473:pathology; D014652:Vascular Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D005337:Fibrin