Effect of treatment with LHRH analogue Zoladex on binding of oestradiol, progesterone and epidermal growth factor to uterine fibromyomata.
Treatment of patients with fibromyomata by Zoladex produces suppression of ovarian function. Receptor changes also occur in fibroids of women treated with Zoladex. The concentration of oestradiol receptors is significantly higher, whilst that of epidermal growth factor and progesterone is significantly lower.
Baird
D T
DT
Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, UK.
Bramley
T A
TA
Hawkins
T A
TA
Lumsden
M A
MA
West
C P
CP
D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D017273:Goserelin; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000378:metabolism; D011959:Receptors, Estradiol / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D017273:Goserelin; D066246:ErbB Receptors; D002064:Buserelin