title: The pathogenesis of cervical spondylosis.
abstract: Cervical spondylosis is a generalized disease process affecting all levels of the cervical spine. Cervical spondylosis encompasses a sequence of degenerative changes in the intervertebral discs, osteophytosis of the vertebral bodies, hypertrophy of the facets and laminal arches, and ligamentous and segmental instability. The natural history of cervical spondylosis is associated with the aging process. Senescent and pathologic processes are thus morphologically indistinguishable. Clinical manifestations of cervical spondylosis may arise when morphologic sequelae are superimposed on a developmentally narrow spinal canal. The two clinical syndromes of spondylotic radiculopathy and myelopathy are distinct, yet they may overlap.
authors.affiliation: Department of Orthopedic Surgery, George Washington University Medical Center, Washington D.C. 20037.
authors.forename: W F
authors.initials: WF
authors.lastname: Lestini
authors.forename: S W
authors.initials: SW
authors.lastname: Wiesel
mesh_terms: D002574:Cervical Vertebrae / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000473:pathology; D009068:Movement; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology; D011859:Radiography; D013118:Spinal Cord Diseases / Q000209:etiology; D013126:Spinal Nerve Roots / Q000473:pathology; D013128:Spinal Osteophytosis / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000266:history / Q000473:pathology / Q000503:physiopathology; D013131:Spine / Q000473:pathology / Q000502:physiology