title: Atrial natriuretic factor: comparability of venous and arterial plasma measurements in man at rest and during exercise.
abstract: 1. Simultaneously obtained arterial and venous plasma atrial natriuretic factor (ANF) concentrations were compared at supine rest and during graded dynamic leg exercise in 10 healthy male subjects (aged 33-51 years). 2. Arterial ANF concentrations ranged between 12 and 179 pg/ml and venous concentrations between 9 and 177 pg/ml. 3. A positive correlation between arterial and venous concentrations was found (r = 0.984). 4. Arterial ANF concentrations were higher than venous concentrations in all pairs of samples (n = 31), but the difference was small and changed little with exercise: the mean difference was 5 pg/ml at rest, 12 pg/ml during submaximal exercise and 6 pg/ml during maximal exercise. 5. The extraction ratios for ANF varied greatly, but were in general lower (P less than 0.05) during maximal exercise (median 0.07, range 0.01-0.32) than at rest (median 0.22, range 0.05-0.33). 6. It was concluded that the plasma ANF concentration in a peripheral arm vein is a good indicator of the systemic peptide concentration at rest as well as during dynamic leg exercise.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Copenhagen, Denmark.
authors.forename: I L
authors.initials: IL
authors.lastname: Kanstrup
authors.forename: P F
authors.initials: PF
authors.lastname: Høilund-Carlsen
authors.forename: M
authors.initials: M
authors.lastname: Damkjaer Nielsen
authors.forename: J
authors.initials: J
authors.lastname: Marving
authors.forename: N
authors.initials: N
authors.lastname: Gadsbøll
mesh_terms: D000328:Adult; D001158:Arteries; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015444:Exercise; D006801:Humans; D008297:Male; D008875:Middle Aged; D014680:Veins
chemical_list: D009320:Atrial Natriuretic Factor