title: Premedication determines the circulatory responses to rapid sequence induction with sufentanil for cardiac surgery.
abstract: Thirty-three patients undergoing elective aortocoronary bypass were allocated randomly to receive morphine 0.1 mg kg-1 i.m. and either lorazepam 50 micrograms kg-1 by mouth or hyoscine 6 micrograms kg-1 i.m. before rapid sequence induction of anaesthesia with sufentanil 5 micrograms kg-1 i.v.and suxamethonium 1 mg kg-1 i.v. Following induction and tracheal intubation, patients premedicated with hyoscine had a significantly higher mean heart rate, mean arterial pressure, cardiac index and left ventricular stroke-work index than patients premedicated with lorazepam. The incidence of new myocardial ischaemia was low in both groups.
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
authors.forename: J F
authors.initials: JF
authors.lastname: Butterworth
authors.forename: V E
authors.initials: VE
authors.lastname: Bean
authors.forename: R L
authors.initials: RL
authors.lastname: Royster
mesh_terms: D000771:Anesthesia, Intravenous; D000777:Anesthetics; D001026:Coronary Artery Bypass; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D011229:Preanesthetic Medication; D012601:Scopolamine / Q000494:pharmacology; D017409:Sufentanil
chemical_list: D000777:Anesthetics; D017409:Sufentanil; D012601:Scopolamine; D008140:Lorazepam; D005283:Fentanyl