Pharmacology of allergen-induced early and late airway responses and antigen-induced airway hyperresponsiveness in allergic sheep.
The pharmacology of antigen-induced early and late phase airway responses and the associated antigen-induced airway hyperresponsiveness was studied in allergic sheep. Data from studies with anti-allergic agents and specific receptor antagonists, especially leukotriene antagonists and antagonists of platelet activating factor (PAF), have led to the hypothesis that allergen-induced late responses in allergic sheep are linked to a heightened metabolism of arachidonic acid via the 5-lipoxygenase pathway. This increases leukotriene production during the acute allergic reaction, which results in a more prolonged acute bronchoconstriction and subsequently a more severe airway inflammation. These recruited inflammatory cells can then release mediators and other cell products which contribute to the late response and airway hyperresponsiveness.
Abraham
W M
WM
Department of Research, Mount Sinai Medical Center, Miami Beach, Florida 33140.
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D012130:Respiratory Hypersensitivity / Q000188:drug therapy / Q000276:immunology*; D012756:Sheep
D000485:Allergens; D000941:Antigens