Significance of left ventricular shape, its blood supply and calcium turnover for evolving myocardial hypertrophy.
To explore relationship between hypertrophy of left ventricle and its shape, blood supply and calcium turnover, the study enrolled 105 male patients with ischemic heart disease or those suspected of its presence. All patients underwent contrast coronary ventriculography, M-mode echocardiography and sectorial scanning. Moderately limited myocardial blood supply was found to be a factor, stimulating its local hypertrophy. In the event of severely impaired blood supply, no substantial myocardial hypertrophy is detectable in corresponding regions, while dynamic observation not infrequently reveals thinning of the wall. Patients with intact coronary arteries, and having more elongated shape of left ventricular cavity, demonstrate larger thickness of walls along the long axis, that is probably due to dependence of intramyocardial tension on the radius of the wall curvature. While performing ventriculography in the patients with hypertrophic myocardium, disclosed elevated level of calcium in the blood and enhanced calcium uptake by cardiac muscle versus patients without left ventricular hypertrophy.
Yanovsky
G V
GV
Stadnyuk
L A
LA
Belonozhko
A G
AG
Stepanenko
A P
AP
Kothiwale
V A
VA
Effimtseva
T K
TK
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D006332:Cardiomegaly / Q000175:diagnosis*; D003326:Coronary Circulation; D006801:Humans; D008297:Male; D008875:Middle Aged
D002118:Calcium