title: Evidence for a further stimulation of atrial natriuretic factor release by atrial pacing in patients with mitral stenosis.
abstract: To investigate the release of atrial natriuretic factor (ANF) in mitral stenosis and the effect of an increased atrial contraction frequency on atrial distension and ANF secretion, we studied 14 patients [New York Heart Association (NYHA) grades II-III] in sinus rhythm, undergoing cardiac catheterization for mitral stenosis. Echocardiographic tracings, repeat determinations of mean pulmonary artery wedge pressure and blood samples from the pulmonary artery for ANF measurements were taken at baseline, during atrial pacing (125 beats/min for 5 min) and 5 min after pacing. After pacing, ANF levels rose markedly with a parallel increase in mean pulmonary artery wedge pressure and left atrial size. These data indicate that atrial pacing is capable of further stimulating ANF release, even in patients with elevated baseline ANF and left atrial pressure and an increased left atrial dimension.
authors.affiliation: Istituto di Clinica Medica Luigi Condorelli, Catania, Italy.
authors.forename: L S
authors.initials: LS
authors.lastname: Malatino
authors.forename: B
authors.initials: B
authors.lastname: Stancanelli
authors.forename: G
authors.initials: G
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Polizzi
authors.forename: C
authors.initials: C
authors.lastname: Leonardi
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: C
authors.initials: C
authors.lastname: Tamburino
authors.forename: G
authors.initials: G
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Giuffrida
authors.forename: G
authors.initials: G
authors.lastname: Tamburino
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000097:blood / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D013997:Time Factors
chemical_list: D009320:Atrial Natriuretic Factor