title: [Lupus anticoagulant antibody (LAC) and juvenile cerebral ischemic attack: a clinical case].
abstract: The lupus anticoagulant (LAC) is an acquired circulating serum immunoglobulin that prolongs all phospholipid-dependent coagulation tests. It has been recently associated with focal cerebral ischemia. We present here a case of LAC associated multiple cerebral ischemic events in a young adult and discuss laboratory criteria for a reliable diagnosis. In order to detect the presence of LAC, both the activated partial thromboplastin time (PTT), the kaolin clotting time (Exner assay) and the tissue thromboplastin inhibition assay (Schleider assay) should be evaluated. We conclude that LAC should be looked for in all young stroke patients with otherwise unexplained cerebral infarctions.
authors.affiliation: Clinica Neurologica, Università degli Studi di Modena.
authors.forename: R
authors.initials: R
authors.lastname: Menabue
authors.forename: V
authors.initials: V
authors.lastname: Bonito
authors.forename: P
authors.initials: P
authors.lastname: Nichelli
mesh_terms: D000328:Adult; D000367:Age Factors; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor
chemical_list: D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor
vernacular_title: Anticorpo anticoagulante lupus (LAC) e ictus ischemico cerebrale giovanile: un contributo clinico.