title: Expression of pregnancy specific beta 1-glycoprotein gene in human placenta and hydatiform mole.
abstract: Transcriptional studies of the placental protein Pregnancy Specific beta 1-Glycoprotein (SP1 or PS beta G) gene with a cDNA probe in Northern blot analysis showed 15-20 folds mRNA increase in term placenta compared with early placenta and hydatiform mole. This value parallels the SP1 amount translated in wheat germ cell-free system. We conclude that SP1 biosynthesis is regulated at transcriptional level during placental development and a similar mechanism would occur in hydatiform mole which is a hyperplastic trophoblast tumor.
authors.affiliation: Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba.
authors.forename: J L
authors.initials: JL
authors.lastname: Bocco
authors.forename: G
authors.initials: G
authors.lastname: Panzetta
authors.forename: A
authors.initials: A
authors.lastname: Flury
authors.forename: L C
authors.initials: LC
authors.lastname: Patrito
mesh_terms: D010582:Bacteriophage lambda / Q000235:genetics; D015152:Blotting, Northern; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010920:Placenta; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000302:isolation & purification; D014158:Transcription, Genetic
chemical_list: D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D012333:RNA, Messenger