A low-energy x-ray irradiator for electrophysiological studies.
A 50 kVp molybdenum target/filter x-ray tube has been installed inside a lead-shielded Faraday cage. High-dose rates of up to 1.54 Gy min-1 (17.4 keV weighted average photons) have been used to conduct local in vitro irradiations of the hippocampal region of guinea pig brains. Electrophysiological recordings of subtle changes in neuronal activity indicate this system is suitable for this application.
Schauer
D A
DA
Armed Forces Radiobiology Research Institute, Bethesda, MD 20814-5145.
Zeman
G H
GH
Pellmar
T C
TC
D000818:Animals; D004594:Electrophysiology; D006168:Guinea Pigs; D006624:Hippocampus / Q000503:physiopathology / Q000528:radiation effects*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D013679:Technology, Radiologic / Q000295:instrumentation*