Regression of oral Kaposi's sarcoma in a case of AIDS on zidovudine (AZT).
A case with oral Kaposi's sarcoma (KS) is reported that regressed during therapy with Zidovudine (AZT) which was started 5 months after the first dermal and oral tumours were noted. After 6 months of treatment the absolute number of T-helper cells had increased from 54/microliters to 232/microliters and the ratio of T-helper to T-suppressor cells from 0.15 to 0.3. During the same time the lesions of KS on the gingiva, uvula and the body as well as the face disappeared. The lesion of KS on the hard palate regressed.
Langford
A
A
Abteilung für zahnärztlichirurgie/Oralchirurgie Nord, Freie Universität, Berlin, F.R.G.
Ruf
B
B
Kunze
R
R
Pohle
H D
HD
Reichart
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D006716:Homosexuality; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory; D015215:Zidovudine / Q000627:therapeutic use*
D015215:Zidovudine