Erythroderma due to ribostamycin.
A 48-year-old man became erythrodermatous after intramuscular administration of ribostamycin, an aminoglycoside antibiotic in the same family as neomycin. Patch tests were positive to ribostamycin and neomycin, as well as to mercurials. There was no mercurial preservative in the injection solution. A lymphocyte transformation test was positive for ribostamycin and tobramycin, but not for gentamycin. Diagnostic and structure-activity relationship aspects of the case are discussed.
Puig
L L
LL
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Spain.
Abadias
M
M
Alomar
A
A
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003875:Drug Eruptions / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012271:Ribostamycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D012271:Ribostamycin