Intraocular penetration of CT-112, an aldose reductase inhibitor, following topical instillation.
Intraocular penetration of 5-(3-ethoxy-4-pentyloxyphenyl)thiazolidine-2,4-dione (CT-112), an aldose reductase inhibitor, was investigated in rabbits following topical instillation. The concentration of CT-112 in corneal epithelium, stroma, endothelium, lens, and aqueous humor, was sequentially determined by high-performance liquid chromatography. CT-112 peaked in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminished time-dependently over a period of 24 hours. CT-112 remained detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation.
Ohashi
Y
Y
Department of Ophthalmology, Osaka University Medical School, Japan.
Awata
T
T
Sogo
S
S
Ohira
M
M
Matsuda
M
M
Fukuda
M
M
Manabe
R
R
D000287:Administration, Topical; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003315:Cornea / Q000378:metabolism*; D003319:Corneal Stroma / Q000378:metabolism; D004728:Endothelium, Corneal / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D045162:Thiazolidinediones
D013844:Thiazoles; D045162:Thiazolidinediones; C051003:risarestat; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase