The action of organic mercury compounds on the function of isolated mammalian heart muscle.
The effects of four organic mercury compounds (methylmercuric chloride; bromomercurihydroypropane, BMHP; chlormerodrin; p-chloromercuribenzoic acid, PCMB) on mechanical and electrical functions of guinea-pig papillary muscles were investigated. An initial decline in contraction force was followed by a transient positive inotropic response. The first was accompanied by a shortening of the action-potential duration and by a reduction of the depolarization velocity and the duration of the Ca2+-dependent slow response. The latter was characterized by an indirect component (release of noradrenaline) and by a direct component, which was dependent on the stimulation rate and on the extracellular concentration of Na+ and K+. The direct positive effect, therefore, was likely to have resulted from inhibition of the sarcolemmal Na+ + K+-ATPase. This notion was confirmed by experiments with isolated membrane particles. The prevalence of the negative or positive inotropic action of these compounds could be ascribed to their lipophilic or hydrophilic properties, respectively.
Halbach
S
S
Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg, F.R.G.
Schönsteiner
G
G
Vierling
W
W
D000200:Action Potentials / Q000187:drug effects; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D002717:Chlormerodrin / Q000494:pharmacology; D002729:Chloromercuribenzoates / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008767:Methylmercury Compounds / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure; D009941:Organomercury Compounds / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D012508:Sarcolemma / Q000187:drug effects / Q000201:enzymology
D002729:Chloromercuribenzoates; D008767:Methylmercury Compounds; D009941:Organomercury Compounds; C000316:1-bromomercuri-2-hydroxypropane; D002717:Chlormerodrin; D000251:Adenosine Triphosphatases; D011188:Potassium