Pituitary function studies in a case of mild Hunter's syndrome (MPS IIB).
Pituitary function studies were performed in a patient with mild Hunter's syndrome (mucopolysaccharidosis type IIB, MPS IIB) in order to exclude growth hormone deficiency as a possible contributing cause of his short stature. The results indicated that anterior pituitary function and, in particular, growth hormone secretion was normal. The most likely explanation for the short stature is an osseous growth plate disturbance with infiltration of the epiphyses by mucopolysaccharides.
Nelson
J
J
Department of Medical Genetics, Queen's University, Belfast.
Carson
D
D
D000293:Adolescent; D006025:Glycosaminoglycans / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006132:Growth Plate / Q000378:metabolism; D006801:Humans; D008297:Male; D016532:Mucopolysaccharidosis II / Q000097:blood* / Q000209:etiology; D010906:Pituitary Hormone-Releasing Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D006025:Glycosaminoglycans; D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D013972:Thyrotropin; D013006:Growth Hormone