title: Inhibition of rat lens aldose reductase by bendazac-L-lysine salt.
abstract: Authors describe the in vitro effect of bendazac-L-lysine salt on the activity of enzyme aldose reductase from rat lens. In the presence of bendazac the activity of the tested enzyme was inhibited. Lineweaver-Burk plot demonstrated that the inhibition was noncompetitive. The possible curative effects on diabetic cataract together with a better way of administration are pointed out.
authors.affiliation: Eye Clinic, First School of Medicine, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Iuliano
authors.forename: M
authors.initials: M
authors.lastname: Menzione
authors.forename: G
authors.initials: G
authors.lastname: Apponi-Battini
authors.forename: C
authors.initials: C
authors.lastname: Costagliola
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000517:prevention & control; D007191:Indazoles / Q000494:pharmacology*; D007700:Kinetics; D007908:Lens, Crystalline / Q000201:enzymology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
chemical_list: D007191:Indazoles; D011720:Pyrazoles; C036067:bendazac lysine; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase