Inhibitory action of dehydroepiandrosterone on methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse.
The present paper reports the chemopreventive action of Dehydroepiandrosterone (DHEA) on Methylcholanthrene- (MCA) induced carcinogenesis in the uterine cervices of adult virgin Swiss albino mice. Placement of sterile double cotton thread impregnated with beeswax containing 600 micrograms of MCA in the cervical canal produced tumors in 85.7% of mice in 16 weeks. When such carcinogen-containing threads were inserted into the uterine cervices of mice that were being fed on diets of 0.025%, 0.05% and 0.1% DHEA for a period of two preinsertion and sixteen postinsertion weeks, the cervical tumor incidences were reduced to 59.0%, 34.7% (P less than 0.01) and 14.2% (P less than 0.01), respectively. It is inferred that DHEA inhibits MCA-induced cervical carcinogenesis and the inhibitory action is dependent upon the dose of the drug.
Rao
A R
AR
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004032:Diet; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D003687:Dehydroepiandrosterone; D008748:Methylcholanthrene