title: The development of long-term potentiation in hippocampus and neocortex.
abstract: The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5, demonstrate a maximal potentiated response around postnatal day 15, and a subsequent decline to adult levels. These results are discussed with respect to the underlying mechanism of action and behavioral significance of these critical-period phenomena.
authors.affiliation: Neurobiology Department, Northeastern Ohio Universities, College of Medicine, Rootstown 44272.
authors.forename: T J
authors.initials: TJ
authors.lastname: Teyler
authors.forename: A T
authors.initials: AT
authors.lastname: Perkins
authors.forename: K M
authors.initials: KM
authors.lastname: Harris
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology