title: Release of atrial natriuretic factor (ANF) induced by acute airway obstruction.
abstract: The aim of this study was to measure the effects of an increase in negative intrathoracic pressure on the release of ANF. With the subjects seated comfortably, 3 control blood samples were obtained over 30 minutes. Eight subjects then breathed for 30 min. through an inspiratory resistance in such a way that maximal inspiratory pleural pressures were between -30 to -40 cmH2O. Three blood samples were withdrawn after 20, 25, and 30 min., with the subject still breathing against the artificial resistance. Plasma concentrations of ANF were analysed by RIA. They measured: control value 24.6 +/- 3.7 pg ANF/mL (X +/- SE); with resistance 37.1 +/- 8.1 pg/mL (p less than or equal to .05). These results suggest that ANF could be released during an asthma attack.
authors.affiliation: Hotel-Dieu, University of Montreal, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Amyot
authors.forename: M C
authors.initials: MC
authors.lastname: Michoud
authors.forename: T
authors.initials: T
authors.lastname: Leduc
authors.forename: S
authors.initials: S
authors.lastname: Marleau
authors.forename: H
authors.initials: H
authors.lastname: Ong
authors.forename: P
authors.initials: P
authors.lastname: DuSouich
authors.forename: P
authors.initials: P
authors.lastname: Larochelle
authors.forename: P
authors.initials: P
authors.lastname: Hamet
authors.forename: O
authors.initials: O
authors.lastname: Küchel
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000097:blood / Q000503:physiopathology*; D000403:Airway Resistance; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D011674:Pulse; D012083:Renin / Q000097:blood
chemical_list: D002395:Catecholamines; D009320:Atrial Natriuretic Factor; D012083:Renin; D006152:Cyclic GMP