T-helper heterogeneity and immune response patterns.
We have long known that helper T cells regulate antibody-dependent humoral responses; we are now beginning to understand how they do so. In murine systems, there are two TH subsets: One secretes IL-2 and gamma-interferon, the other IL-4 and IL-5. The helper-subset-specific cytokines affect B cells, and therefore the regulation of antibody secretion, in profoundly different ways.
Coffman
R L
RL
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, Calif.
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4; D015848:Interleukin-5; D007378:Interleukins / Q000378:metabolism*; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification* / Q000502:physiology
D000906:Antibodies; D007136:Immunoglobulins; D007376:Interleukin-2; D015848:Interleukin-5; D007378:Interleukins; D015847:Interleukin-4; D007371:Interferon-gamma