A comparison of metoclopramide and trimebutine on small bowel motility in humans.
Trimebutine meleate and metoclopramide increase small bowel motility. The present manometric study of the human normal interdigestive duodeno-jejunal motility demonstrated two different pharmacological effects in 15 healthy volunteers. Trimebutine constantly induced a premature phase 3 activity (0.81 +/- 0.4 min after a 100-mg intravenous injection) with patterns similar to spontaneous phase 3. Metoclopramide increased the motility index (contractile activity) during phase 2 without inducing a premature phase 3. No significant variations in plasma motilin concentration were noticed after either trimebutine or metoclopramide. The pancreatic polypeptide concentration rose significantly after metoclopramide injection.
Grandjouan
S
S
Service d'Hépato-gastroenterologie, Hôpital Cochin, Paris, France.
Chaussade
S
S
Couturier
D
D
Thierman-Duffaud
D
D
Henry
J F
JF
D000328:Adult; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D009037:Motilin / Q000097:blood; D016065:Myoelectric Complex, Migrating / Q000187:drug effects; D010191:Pancreatic Polypeptide / Q000097:blood; D010455:Peptides / Q000097:blood; D014287:Trimebutine / Q000494:pharmacology*
D010455:Peptides; D009037:Motilin; D010191:Pancreatic Polypeptide; D008787:Metoclopramide; D014287:Trimebutine