title: The regularity of smoked marijuana self-administration.
abstract: Three male research volunteers lived in a residential laboratory for 12 days in a study designed to investigate factors controlling patterns of marijuana smoking. All contact with the experimenters was through a networked computer system and subjects' behaviors were continuously recorded. During the first six hr of the day (0945-1545), subjects remained in their private rooms engaging in planned work activities, and during the remainder of the day (7 3/4 hr) they were allowed to socialize (1600-2345). Subjects were instructed that up to five active marijuana cigarettes (1.84% delta 9 w/w THC) could be smoked on designated days between 0945 and 2200. Cigarettes were available on request. Subjects requested all five cigarettes on 15 of 18 possible occasions (three subjects x six days of availability) with a mean latency to the first cigarette of 22 min. The pattern of self-administration was remarkably similar among subjects with all subjects smoking two cigarettes during the private work period and three cigarettes during the social access period. Subjects 1 and 2 smoked 90% of their social period cigarettes together in the social area, while Subject 3 smoked all of his cigarettes alone in his private room.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: R W
authors.initials: RW
authors.lastname: Foltin
authors.forename: M W
authors.initials: MW
authors.lastname: Fischman
authors.forename: J V
authors.initials: JV
authors.lastname: Brady
authors.forename: R M
authors.initials: RM
authors.lastname: Capriotti
authors.forename: C S
authors.initials: CS
authors.lastname: Emurian
mesh_terms: D000328:Adult; D013759:Dronabinol / Q000032:analysis; D002149:Energy Intake; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000523:psychology*
chemical_list: D013759:Dronabinol