Problems in the physiology of class I and class II MHC molecules, and of CD45.
1. Co-processing of alloantigens suggests that epitope-loaded MHC class I molecules may pass from tissue cells to dendritic cells. 2. Antigen-presenting cells in the thymus need some special trick in order to load their MHC class II molecules with epitopes from "intermediate concentration" self-proteins in order to induce self-tolerance in developing cells. 3. Cell-cell interactions may transmit signals simply by rearranging surface glycoproteins and thus locally perturbing a phosphorylation equilibrium. 4. The CD45 and STB1 phenotype of most cells in the thymus may be characteristic of a doomed cell.
Fisher
A G
AG
Imperial Cancer Research Fund, University College London, United Kingdom.
Goff
L K
LK
Lightstone
L
L
Marvel
J
J
Mitchison
N A
NA
Poirier
G
G
Stauss
H
H
Zamoyska
R
R
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D017493:Leukocyte Common Antigens; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology; D008954:Models, Biological; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins; D017493:Leukocyte Common Antigens