Quantitative binding of Fc-receptors, and antibody-dependent cell-mediated cytotoxicity of blood lymphocytes in healthy and chronic lymphocytic leukemic cattle.
The binding capacity of Fc-receptors for IgG of blood lymphocytes was studied in healthy cattle and cattle with chronic lymphocytic leukemia before and after incubation at 37 degrees C in basal Eagle's medium without serum. It was found that lymphocytes of leukemic cattle possess twice the amount of Fc-receptors found in normal lymphocytes. The changes in the binding capacity of Fc-receptors for IgG of normal and leukemic lymphocytes correlated with those of antibody-dependent cell-mediated cytotoxicity (ADCC) of the corresponding lymphocytes. The lower ADCC of leukemic lymphocytes in comparison with normal ones was accompanied by a lower association constant of the leukemic lymphocyte Fc-receptors towards IgG.
Dikiniene
N
N
Institute of Biochemistry Academy of Sciences of the Lithuanian SSR, Vilnius.
Miliukiene
V
V
Dediniene
J
J
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000943:Antigens, Differentiation / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D007074:Immunoglobulin G / Q000378:metabolism; D007700:Kinetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000662:veterinary*; D011961:Receptors, Fc / Q000378:metabolism*; D017452:Receptors, IgG
D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG