Blood pressure responses to enalapril in rats with one- and two-kidney DOC-NaCl hypertension.
Blood pressure responses to the angiotensin-converting enzyme (ACE) inhibitor enalapril were investigated in rats with salt-dependent hypertension. In both one- and two-kidney deoxycorticosterone (DOC)-NaCl hypertension, enalapril (50 mg/kg p.o.) caused a similar, slight blood pressure fall, which passed off with continuation of the treatment. Changes in the salt concentration of the drinking fluid (from 1% NaCl to 0.2% NaCl in the one-kidney rats and from 1% NaCl to 2% NaCl in those with intact kidneys) did not alter the depressor effect of enalapril. Plasma renin activity in all DOC-NaCl hypertensive groups was negligible. Our results indicate that in DOC-NaCl hypertensive rats, the presence of intact kidneys vs. one kidney has no influence on the blood pressure response to ACE inhibition. The blood pressure-lowering effect of enalapril may result from local converting enzyme inhibition in tissues.
Arvola
P
P
Department of Biomedical Sciences, University of Tampere, Finland.
Nurmi
A K
AK
Säynävälammi
P
P
Manninen
V
V
Vapaatalo
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003900:Desoxycorticosterone; D004326:Drinking / Q000187:drug effects; D004656:Enalapril / Q000494:pharmacology*; D006977:Hypertension, Renal / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D004656:Enalapril; D012083:Renin