Prolactin response to TRH is unaltered by pulsatile infusion of LHRH.
Eleven boys with constitutional delay of puberty and 7 patients with hypogonadotrophic hypogonadism underwent standard thyrotrophin-releasing hormone (TRH) tests prior to and following 6 days' pulsatile infusion of luteinizing hormone-releasing hormone (240 ng/kg/pulse). There were no significant differences in basal, peak or incremental prolactin responses to TRH between the 2 groups of patients and there were no differences in the magnitude of prolactin response to TRH in either group of patients during pulsatile therapy when compared with preinfusion responses.
Gordon
D
D
University Department of Medicine, Royal Infirmary, Glasgow, UK.
Beastall
G H
GH
Thomson
J A
JA
D000293:Adolescent; D000328:Adult; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007006:Hypogonadism / Q000097:blood; D007262:Infusions, Intravenous; D007457:Iodine Radioisotopes; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*; D011628:Puberty, Delayed / Q000097:blood; D013739:Testosterone / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone