Suxamethonium--the relation between dose and response.
In a study which involved 120 adult patients, the ED95 of suxamethonium was shown to be 0.51 mg/kg, using an electromyographic technique. Marked individual variation in response was noted, for example a dose of 0.3 mg/kg produced a range of blockade from 4%-90%. Body surface area was shown to be more significantly related to blockade than lean body mass or total body weight.
Chestnut
R J
RJ
University Department of Anaesthesia, Withington Hospital, Manchester.
Healy
T E
TE
Harper
N J
NJ
Faragher
E B
EB
D000293:Adolescent; D000328:Adult; D000368:Aged; D001830:Body Surface Area; D001835:Body Weight; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D013390:Succinylcholine