title: Experimental murine schistosomiasis mansoni: hyperplasia of the mono-macrophage cell lineage and stimulation of myeloid proliferation by peripheral macrophages.
abstract: 1. Normal and schistosome-infected mice were similar in terms of the total number of bone marrow myeloid cell precursors and their proliferative capacity in vitro when stimulated with supernatants of L-929 cells containing M-CSF. 2. Delayed differentiation of bone marrow neutrophil granulocytes and blood monocytosis of infected animals were consistent with a modification in the differentiation of bone marrow myeloid precursors, favoring the production of a mono-macrophage cell lineage. 3. Macrophages isolated from periovular granulomas secreted a considerable stimulatory activity for the proliferation of the mono-macrophagic cell lineage, whereas peritoneal macrophages from the same animals had only a very low stimulatory activity. 4. We conclude that systemic hyperplasia of mono-macrophagic cells in schistosomiasis may be related to their increased release from the bone marrow and to their peripheral amplification in inflammatory tissue infiltrate as a consequence of the local production of stimulatory activity for their proliferation.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Borojevic
authors.forename: C G
authors.initials: CG
authors.lastname: Pinto
authors.forename: M C
authors.initials: MC
authors.lastname: el-Cheikh
authors.forename: H S
authors.initials: HS
authors.lastname: Dutra
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D066298:In Vitro Techniques; D007962:Leukocytes / Q000032:analysis*; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000032:analysis*; D012555:Schistosomiasis mansoni / Q000473:pathology*