Hydroxylation and N-demethylation of clarithromycin (6-O-methylerythromycin A) by Mucor circinelloides.
Adachi
T
T
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Sasaki
J
J
Omura
S
S
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006900:Hydroxylation; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000378:metabolism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; C061228:16-hydroxyclarithromycin; D004917:Erythromycin; D017291:Clarithromycin