cAMP levels in monocytes of heroin addicts.
Intravenous heroin addicts have a high intracellular cAMP level in relation to control monocytes. Incubation in vitro with ascorbic acid normalizes the cellular content of cAMP. We discuss the role of cAMP in the pathogenesis of defective monocyte chemotaxis in intravenous heroin addicts.
Castrillón
J L
JL
Departamento de Patologia General, Hospital Clinico Universitario, Salamanca Hispania.
Arellano
J L
JL
Palomo
J D
JD
Rodriguez
M M
MM
López
A J
AJ
D000293:Adolescent; D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008297:Male
D000242:Cyclic AMP; D001205:Ascorbic Acid