[The possibility for modification of the cytogenetic action of secondary radiation with 70-GeV protons on Chinese hamster fibroblasts].
As estimated by the cytogenetic injury induced in Chinese hamster cells by secondary 70-GeV proton radiation, phenylmethylsulfonyl fluoride, an inhibitor of chromatin proteinases, has a radioprotective effect. The poly(ADP)-ribosylation-independent participation of the inhibitor in radiation cytogenetic mutagenesis has been shown.
Livanov
I A
IA
Zaichkina
S I
SI
Aptikaeva
G F
GF
Antipov
A V
AV
Akhmadieva
A Kh
AKh
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects*; D015162:Micronucleus Tests; D009536:Niacinamide / Q000494:pharmacology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D011522:Protons; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011522:Protons; D011837:Radiation-Protective Agents; D009536:Niacinamide; D010664:Phenylmethylsulfonyl Fluoride
Issledovanie vozmozhnosti modifikatsii tsitogeneticheskogo deĭstviia vtorichnogo izlucheniia ot protonov s énergieĭ 70 GéV na fibroblasty kitaĭskogo khomiachka.