Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).
Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.
Van Snick
J
J
Ludwig Institute for Cancer Research, Brussels, Belgium.
Goethals
A
A
Renauld
J C
JC
Van Roost
E
E
Uyttenhove
C
C
Rubira
M R
MR
Moritz
R L
RL
Simpson
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics*; D006133:Growth Substances / Q000235:genetics*; D016906:Interleukin-9; D008222:Lymphokines / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D013601:T-Lymphocytes / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology
D006023:Glycoproteins; D006133:Growth Substances; D016906:Interleukin-9; D008222:Lymphokines; D012333:RNA, Messenger