[Immunologic tolerance].
The thymus plays a major role in T-cell maturation. Non-mature, bone-marrow-derived T-lymphocytes differentiate in the thymus into functional helper and cytotoxic T-cells, which have undergone two types of selection events before they leave the thymus: The negative selection, that is the elimination of self-reactive T-cells, and the positive selection, which supports the survival of T-cells capable of recognizing foreign antigen together with self-major histocompatibility antigens. Induction of T-cell tolerance towards the self-antigen Mlsa as a model is mediated by the selective deletion of Mlsa-reactive T-cells in the cortical region of the thymus. This was demonstrated by histological and flow cytofluorometrical analysis with a T-cell receptor variable-region-specific monoclonal antibody.
Hengartner
H
H
D001327:Autoimmune Diseases / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007108:Immune Tolerance; D007135:Immunoglobulin Variable Region / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D007135:Immunoglobulin Variable Region; D007519:Isoantigens; D011971:Receptors, Immunologic
Uber die immunologische Toleranz.