title: The protein kinases tightly bound to DNA are present in normal tissues and in regenerating liver, but strongly decreased in hepatomas.
abstract: We have previously described in rat liver two protein kinases tightly bound to DNA, one is serine-specific, the other arginine-specific. In this work we show that both enzymes are present in various rat tissues and in liver from various species. Both kinase specific activities are strongly decreased in methyl-DBA-induced hepatomas and in HTC cells but not in regenerating liver after hepatectomy. This decrease is then not related to cell proliferation.
authors.affiliation: Institut de Pathologie Moléculaire, Unité de Recherches Associée au CNRS URA 1147, Faculté de Médecine Cochin-Port-Royal, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Levy-Favatier
authors.forename: L
authors.initials: L
authors.lastname: Tichnonicky
authors.forename: J
authors.initials: J
authors.lastname: Kruh
authors.forename: M
authors.initials: M
authors.lastname: Delpech
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006498:Hepatectomy; D008114:Liver Neoplasms, Experimental / Q000201:enzymology* / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D012694:Serine; D004247:DNA; D001120:Arginine; D011494:Protein Kinases