[Effect of nitrosodimethylamine at various concentrations on various enzymatic systems in rat kidney endoplasmic reticulum and mitochondria depending on the duration of drug action].
Dissimilar response of rat kidney microsomal and mitochondrial enzymes was observed after administration of nitrosodimethylamine at concentrations 0.1, 1.0 and 10.0 mg/L within 2, 5 and 10 months. Activity of the mitochondrial enzymes studied depended to a greater degree on concentration of the drug administered as compared with duration of its effect. At the same time, activity of the microsomal enzymes studied was increased depending on duration of nitroso-++ dimethylamine action administered at concentration of 0.1 mg/L, while it did not alter if concentration of the drug was increased from 1.0 to 10.0 mg/L within the all periods of examination.
Litvinov
N N
NN
Astakhova
L F
LF
Dolinskaia
S I
SI
D000818:Animals; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D006180:Proton-Translocating ATPases / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D013385:Succinate Dehydrogenase; D006180:Proton-Translocating ATPases; D004128:Dimethylnitrosamine
Vliianie razlichnykh kontsentratsiĭ nitrozodimetilamina v zavisimosti ot dlitel'nosti vozdeĭstviia na nekotorye fermentnye sistemy éndoplazmaticheskoĭ seti i mitokhondriĭ pochek krys.