Human fetal Schwann cells in culture: phenotypic expressions and proliferative capability.
In this report we examined the phenotypic expressions and the proliferative capability of cultured human fetal Schwann cells. Antigens that were expressed included laminin, nerve growth factor receptor, neural cell adhesion molecule, S-100 protein, and that recognized by the monoclonal antibody HNK-1. In addition, HLA-A,B,C and HLA-DR, respectively, class I and class II antigens of the major histocompatibility complex, were demonstrated on Schwann cells. Mitotic capability was high, with an average of 34% of Schwann cells undergoing proliferation over a 2-day period.
Kim
S U
SU
Division of Neurology, Department of Medicine, Health Sciences Centre Hospital, University of British Columbia, Vancouver.
Yong
V W
VW
Watabe
K
K
Shin
D H
DH
D000954:Antigens, Surface / Q000378:metabolism*; D002452:Cell Count; D002455:Cell Division; D002478:Cells, Cultured; D005333:Fetus; D005727:Ganglia, Spinal / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D005865:Gestational Age; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor; D012583:Schwann Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism
D000954:Antigens, Surface; D006680:HLA Antigens; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor