IgG class anti-cardiolipin antibody as a possible marker for evaluating fetal risk in patients with systemic lupus erythematosus.
To identify the correlation between incidence of anti-phospholipid antibodies and fetal prognosis in pregnant SLE patients, we measured the amount of anti-cardiolipin antibody in their sera, using solid-phase enzyme immunoassay (EIA) methods. Findings in the group having poor obstetric results (fetal loss group) and in those with a history of full-term births (live birth group) were compared with regard to other anti-phospholipid antibodies. The incidence of IgG class anti-cardiolipin antibody was 60% in the fetal loss group and 19% in the live birth group, (P less than 0.05). The incidence of the other anti-phospholipid antibodies, including lupus anticoagulant and biological false-positive serological test for syphilis (BFP-STS), did not differ significantly between the two groups. Therefore, the presence of IgG class anti-cardiolipin antibody may prove to be a useful marker for evaluating fetal risk in SLE patients.
Shimada
K
K
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Koike
T
T
Ichikawa
K
K
Tsutsumi
A
A
Takabayashi
K
K
Tomioka
H
H
Yoshida
S
S
D015415:Biomarkers; D001779:Blood Coagulation Factors / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology* / Q000378:metabolism; D016009:Chi-Square Distribution; D005260:Female; D005333:Fetus; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011256:Pregnancy Outcome; D012307:Risk Factors; D013588:Syphilis Serodiagnosis
D015415:Biomarkers; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D007074:Immunoglobulin G; D016682:Lupus Coagulation Inhibitor