title: Ki-1-positive cutaneous large cell lymphoma of T cell type: report of an indolent subtype.
abstract: T cell lymphomas that demonstrate skin involvement include not only mycosis fungoides and Sézary syndrome but also a wide variety of other T cell neoplasms. Whether any specific clinicopathologic associations exist for nonmycosis fungoides/Sézary syndrome cutaneous T cell lymphomas is not known, and whether they represent distinct entities or a spectrum of a similar disease process also is not known. We describe a patient with a localized cutaneous large cell lymphoma with a Ki-1-positive "aberrant" T helper/inducer phenotype. Clonal rearrangement of the T cell receptor gene was documented. Although these histologic characteristics and immunophenotype are usually associated with high-grade lymphomas, the patient appears clinically to have a much less aggressive neoplasm. The possible relationship of this overt lymphoma to lymphomatoid papulosis is discussed.
authors.affiliation: Department of Dermatology, University of Minnesota, College of Medicine, Minneapolis.
authors.forename: J S
authors.initials: JS
authors.lastname: Lindholm
authors.forename: D R
authors.initials: DR
authors.lastname: Barron
authors.forename: M E
authors.initials: ME
authors.lastname: Williams
authors.forename: S H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D000943:Antigens, Differentiation / Q000032:analysis* / Q000235:genetics; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D017730:Ki-1 Antigen; D008223:Lymphoma / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012878:Skin Neoplasms / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; D017730:Ki-1 Antigen