Cytogenetic characterization of a colon adenocarcinoma from a familial polyposis coli patient.
We report on the cytogenetic findings in a fresh biopsy of a colorectal adenocarcinoma in a patient with familial polyposis coli (FAP). The stemline had 45 chromosomes with several clonal chromosome aberrations including a der(17)t(17;?), and -18, which are the two most recurrent aberrations in sporadic colorectal carcinomas. This finding is discussed in relation to the chromosomal changes described in sporadic colorectal carcinomas and in FAP cell lines.
Muleris
M
M
Department of Biology, Institut Curie, Paris, France.
Nordlinger
B
B
Dutrillaux
B
B
D000230:Adenocarcinoma / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured