[Properties of benzodiazepine receptors of the cerebral cortex of rats with various degrees of ethanol preference].
Comparative study of [3H]-flunitrazepam binding to brain cortex benzodiazepine receptors was performed in rats with different preference to ethanol divided into following groups: 1, rejecting 15% ethanol which was not accessible for 3 months; 2, preferring 15% ethanol freely accessible for 3 months; 3, preferring alcohol and having free access to it except for the last 24 h before decapitation; 4, preferring ethanol not accessible for 3 months. Considerable fall in benzodiazepine receptor affinity was detected in Group 4 as compared to Group 1 (alpha = 0.012; p less than 0.01). The corresponding numbers of [3H]-flunitrazepam binding sites were not different. The data were nonuniform in Groups 2 and 3. Comparison between the two populations substantially different in preferring (Groups 2, 3, 4) and rejecting (Group 1) ethanol reflects the general trend of reduction on the benzodiazepine receptors affinity in preferring rats. This can be a part of biological basis for shaping the craving for alcohol.
Shushpanova
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D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004361:Drug Tolerance; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D005445:Flunitrazepam / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
D011963:Receptors, GABA-A; D000431:Ethanol; D005445:Flunitrazepam
Svoĭstva benzodiazepinovykh retseptorov kory golovnogo mozga krys s raznoĭ stepen'iu predpochteniia k etanolu.