title: [Multicenter clinical study of the antihypertensive activity of lisinopril].
abstract: One-hundred patients suffering from slight-moderate hypertension (53 m, 47 f, aged between 18 and 78, average 49.08) have been studied in order to assess the effectiveness and tolerance of lisinopril ("Zestril", ICI-Pharma), a new ACE inhibitor in a single daily administration at doses of between 10 and 80 mg in relation to pressure values. Monotherapy with Lisinopril proved effective in 84 patients (88.4%), in 74 of whom (7.9%) pressure values were returned to normal. 11 patients (11.6%) did not respond to treatment. In most cases, the result was obtained with a dose of 20 mg in a single administration (32.6%). The incidence of side-effects was limited and in no case required the withdrawal of the drug.
authors.affiliation: Policlinico Umberto I, Roma.
authors.forename: G A
authors.initials: GA
authors.lastname: Cinotti
authors.forename: A
authors.initials: A
authors.lastname: Bossini
authors.forename: V
authors.initials: V
authors.lastname: Cagli
authors.forename: L
authors.initials: L
authors.lastname: Corea
authors.forename: C
authors.initials: C
authors.lastname: Di Veroli
authors.forename: S
authors.initials: S
authors.lastname: Morabito
authors.forename: A
authors.initials: A
authors.lastname: Pierucci
authors.forename: C
authors.initials: C
authors.lastname: Porcellati
authors.forename: K
authors.initials: K
authors.lastname: Savino
authors.forename: M
authors.initials: M
authors.lastname: Timio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004361:Drug Tolerance; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011187:Posture; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril; D017706:Lisinopril
vernacular_title: Studio clinico multicentrico sull'attività antiipertensiva del Lisinopril.