Clinical efficacy of 99mtechnetium mercaptoacetylglycine kit formulation in routine renal scintigraphy.
99mTechnetium mercaptoacetylglycine is a promising new renal radiopharmaceutical undergoing phase III trials in the United States. In a preliminary investigation of the efficacy and safety of mercaptoacetylglycine in 30 adult patients with suspected renal disease we used simultaneous imaging with orthoiodohippurate as the physiological "gold standard". Of these patients 11 had undergone renal transplantation. Factors, such as time to peak renal activity, clearance half-life and regional functional comparison, were similar by orthoiodohippurate and mercaptoacetylglycine imaging. Visual and quantitative analysis of angiograms and renograms was markedly facilitated with the use of mercaptoacetylglycine. Several morphological abnormalities were apparent only during mercaptoacetylglycine evaluation. No adverse effects, changes in vital signs or significant changes in clinical laboratory status were encountered. Since mercaptoacetylglycine combined an excellent technetium image with the pharmacokinetics of orthoiodohippurate, mercaptoacetylglycine may supplant all other agents for routine clinical use.
duCret
R P
RP
Division of Nuclear Medicine, University of Minnesota Hospital and Clinics, Minneapolis 55455.
Boudreau
R J
RJ
Gonzalez
R
R
Carpenter
R
R
Tennison
J
J
Kuni
C C
CC
D000328:Adult; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation; D009842:Oligopeptides / Q000493:pharmacokinetics; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D012079:Renal Circulation; D013667:Technetium; D017263:Technetium Tc 99m Mertiatide
D007457:Iodine Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D011933:Reagent Kits, Diagnostic; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium