title: The production by 72 MeV protons of keV neutrons for 10B neutron capture therapy.
abstract: Fast neutrons, produced in a spallation process by 72 MeV protons hitting heavy nuclei, can be moderated down to keV energies, suitable for 10B capture therapy. Measurements of neutron flux from copper and lead targets, after moderation by water and hydrocarbons, have been performed, together with measurements of the fast neutron and gamma-backgrounds. The comparisons with Monte Carlo calculations show good agreement. As neutron fluences up to 10(12) to 10(13)n/cm2 can be produced within a few hours in about 0.5 m target distance the technique seems to be suitable for clinical experiments.
authors.affiliation: University of Uppsala, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Condé
authors.forename: J F
authors.initials: JF
authors.lastname: Crawford
authors.forename: B
authors.initials: B
authors.lastname: Dahl
authors.forename: E
authors.initials: E
authors.lastname: Grusell
authors.forename: B
authors.initials: B
authors.lastname: Larsson
authors.forename: C B
authors.initials: CB
authors.lastname: Petterson
authors.forename: H
authors.initials: H
authors.lastname: Reist
authors.forename: N G
authors.initials: NG
authors.lastname: Sjöstrand
authors.forename: O
authors.initials: O
authors.lastname: Sornsuntisook
authors.forename: L
authors.initials: L
authors.lastname: Thuresson
mesh_terms: D001895:Boron / Q000627:therapeutic use*; D005214:Fast Neutrons; D006801:Humans; D007554:Isotopes; D009010:Monte Carlo Method; D009502:Neutrons; D010315:Particle Accelerators; D011522:Protons; D011879:Radiotherapy Dosage
chemical_list: D007554:Isotopes; D011522:Protons; D001895:Boron