title: The lack of effect of repeated treatment with antidepressant drugs on the 8-OH-DPAT-induced increase in the serum corticosterone concentration.
abstract: We studied the effect of repeated treatment (twice daily for 14 consecutive days) with the antidepressant drugs imipramine, citalopram and mianserin (all the drugs administered in a dose of 10 mg/kg po) on the 8-OH-DPAT-induced increase in the serum corticosterone concentration. We found that all those drugs affected neither basal nor 8-OH-DPAT-induced increase in the corticosterone concentration. These results suggest that long-term administration of the investigated antidepressant drugs does not modify the functional sensitivity of central 5-HT1A receptors.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: E
authors.initials: E
authors.lastname: Przegaliński
authors.forename: A
authors.initials: A
authors.lastname: Warchoł-Kania
authors.forename: B
authors.initials: B
authors.lastname: Budziszewska
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D015283:Citalopram; D008803:Mianserin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007099:Imipramine; D003345:Corticosterone