Long-term effects of lithium on the kidney: functional-morphological correlations.
Correlations between quantitative kidney biopsy findings and clinical renal function in 46 unselected patients treated with lithium for an average of eight years were studied. A significant relationship between maximum renal concentrating capacity and degree of tubular atrophy was found. GFR correlated significantly with sclerotic glomeruli as well as atrophic tubules in patients on a multiple dosage schedule, whereas no relationship was seen in patients receiving lithium in a single daily dose. Thus, renal dysfunction may have a structural basis in a subgroup of lithium-treated patients on a multiple dosage schedule.
Hetmar
O
O
Department of Psychiatry, Rigshospitalet, University of Copenhagen, Denmark.
Brun
C
C
Ladefoged
J
J
Larsen
S
S
Bolwig
T G
TG
D000328:Adult; D000368:Aged; D001706:Biopsy; D001714:Bipolar Disorder / Q000188:drug therapy*; D002951:Citrates; D003692:Delayed-Action Preparations; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000473:pathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000473:pathology; D007677:Kidney Function Tests; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D016651:Lithium Carbonate; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
D002951:Citrates; D003692:Delayed-Action Preparations; D016651:Lithium Carbonate; C070669:lithium citrate; D008094:Lithium