title: A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.
abstract: A double-blind, randomized multi-centre study was performed to evaluate the efficacy of a 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm). One-hundred and twenty-two patients suffering from acne vulgaris were treated with either Zineryt lotion or 2% erythromycin lotion. Acne grading and lesion counts for comedones, papules, pustules, nodules and macules were performed at each visit at 0, 1, 2, 4, 8 and 12 weeks. Treatment with Zineryt lotion was found to be more effective than with 2% erythromycin as regards the reduction in number of the acne lesions and the severity grade of the acne.
authors.affiliation: Department of Dermatology, University Hospital, Dijkzigt, Rotterdam, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Habbema
authors.forename: B
authors.initials: B
authors.lastname: Koopmans
authors.forename: H E
authors.initials: HE
authors.lastname: Menke
authors.forename: S
authors.initials: S
authors.lastname: Doornweerd
authors.forename: K
authors.initials: K
authors.lastname: De Boulle
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D019342:Acetic Acid; D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic
chemical_list: D000085:Acetates; D004338:Drug Combinations; D004917:Erythromycin; D019342:Acetic Acid