title: Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated.
abstract: relA and spoT are designations for two unlinked Escherichia coli genes whose products function in the synthesis and degradation of guanosine 3',5'-bispyrophosphate during the stringent regulatory response to amino acid deprivation. The RelA protein catalyzes an ATP:GTP 3'-pyrophosphoryl group transfer reaction, and the SpoT protein has a guanosine 3',5'-bispyrophosphate 3'-pyrophosphohydrolyase activity. Both genes have been sequenced recently; the relA gene produces an 84-kDa protein, and the spoT gene is deduced to encode a 79-kDa protein. We report here that the protein sequences of the relA and spoT genes are extensively interrelated.
authors.affiliation: Department of Cellular Biochemistry, Hadassah Medical School, Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Metzger
authors.forename: E
authors.initials: E
authors.lastname: Sarubbi
authors.forename: G
authors.initials: G
authors.lastname: Glaser
authors.forename: M
authors.initials: M
authors.lastname: Cashel
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000302:isolation & purification*; D001483:Base Sequence; D003062:Codon / Q000032:analysis; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial; D006150:Guanine Nucleotides / Q000235:genetics*; D006159:Guanosine Tetraphosphate / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001426:Bacterial Proteins; D003062:Codon; D006150:Guanine Nucleotides; D006159:Guanosine Tetraphosphate