10-Hydroxynortriptyline and treatment effects in elderly depressed patients.
Sixty-four elderly depressed outpatients were treated with nortriptyline for seven weeks. Plasma nortriptyline and its main metabolite, 10-hydroxynortriptyline, were measured weekly. No relationship was found between levels of 10-hydroxynortriptyline and clinical response. Plasma levels of the trans isomer, E-10-hydroxynortriptyline, were significantly lower when dizziness and symptoms of orthostatic hypotension were reported, although there was no significant correlation with actual orthostatic drop in systolic pressure. Plasma level of 10-hydroxynortriptyline was not significantly correlated with the other reported side effects.
McCue
R E
RE
Department of Psychiatry, New York University School of Medicine, New York 10016.
Georgotas
A
A
Suckow
R F
RF
Cooper
T B
TB
D000368:Aged; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010555:Personality Inventory; D010624:Phenelzine / Q000493:pharmacokinetics / Q000627:therapeutic use; D016037:Single-Blind Method; D013237:Stereoisomerism
C013567:10-hydroxynortriptyline; D009661:Nortriptyline; D010624:Phenelzine