title: Brugia malayi: status of host during different stages of infection.
abstract: The status of glycogen, protein, lipid components, lipid peroxides and a few enzymes of energy metabolism was studied in liver of Mastomys natalensis during the development of Brugia malayi infection. Glycogen and lipid contents were decreased during the patent phase of infection while total protein was slightly altered in latent animals. Phospholipid and triglyceride contents declined at prepatent and patent phase of infection. The levels of lactate and malate dehydrogenases, as well as of adenosine triphosphatases (Na+K+, Mg2+, Ca2+), were significantly elevated and monoamine oxidase activity was decreased at patent phase of infection, while succinic dehydrogenase remained unaltered. The lipid peroxide formation was enhanced in liver during the development of filarial infection.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Joshi
authors.forename: J K
authors.initials: JK
authors.lastname: Saxena
authors.forename: P K
authors.initials: PK
authors.lastname: Murthy
authors.forename: A B
authors.initials: AB
authors.lastname: Sen
authors.forename: S
authors.initials: S
authors.lastname: Ghatak
mesh_terms: D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D002009:Brugia; D002784:Cholesterol / Q000032:analysis; D004605:Elephantiasis, Filarial / Q000378:metabolism*; D004734:Energy Metabolism; D005368:Filariasis / Q000378:metabolism*; D006003:Glycogen / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008054:Lipid Peroxides / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000032:analysis; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D009115:Muridae; D010743:Phospholipids / Q000032:analysis; D011506:Proteins / Q000032:analysis; D013385:Succinate Dehydrogenase / Q000032:analysis; D014280:Triglycerides / Q000032:analysis
chemical_list: D008054:Lipid Peroxides; D010743:Phospholipids; D011506:Proteins; D014280:Triglycerides; D006003:Glycogen; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D000251:Adenosine Triphosphatases