The effect of alpha-tocopherol and Intal on heart capillary bed and lipid peroxide oxidation in experimental necrosis of the rat myocardium.
The effect of Intal and alpha-tocopherol on the morphofunctional state of myocardial capillary bed and peroxide oxidation of lipids (POL) was studied in 160 albino rats with coronary artery occlusion. The vascular effect of Intal consisted in increasing the number of functioning capillaries and enlargement of their exchange surface. alpha-tocopherol proved to be less effective in this respect. The authors assume that besides its influence on myocardial microcirculation through POL reduction, Intal supports the increase in the number of functioning capillaries.
Amatuni
V G
VG
Department of Biology, Medical Institute, Yerevan, USSR.
Matevosian
R S
RS
Sisakian
S A
SA
Arakelian
I G
IG
D000818:Animals; D002196:Capillaries / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D004205:Cromolyn Sodium / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D004205:Cromolyn Sodium