title: [Surgical treatment of 48 primary peripheral, non-small cell lung cancers equal to or greater than 8 cm. Prognostic factors and 5 years' survival].
abstract: In a series of 885 resections for lung carcinoma performed between 1976 and 1986, 48 (5.5%) were for large size tumors of 8 cm and over. Pneumonectomy was performed in 28 patients (58.3%), lobectomy in 17 (35.5%) and bilobectomy in 3 (6.2). Histological type of tumor was squamous cell in 27, adenocarcinoma in 9, large cell carcinoma in 10, and adenosquamous carcinoma in 2. The stage of the disease was stage I in 16 cases, stage II in 3 cases, and stage III in 29 cases. Total survival rate including perioperative mortality (3 deaths) was 30.5% at 3 years and 16.3% at 5 years. The best prognostic factors are: age under 60 (23% survival at 5 years, and no survival over 60, (p = 0.01), absence of weight loss (24% survival at 3 years, and 14% at 3 years in case of weight loss (p = 0.02), absence of symptoms (44% at 3 years) but no survival in case of symptoms (p = 0.02), no invasion of mediastinal lymph nodes (N0 and N1), and stage I and II of the disease (50% of survival at 3 years against 20% for stage III (p = 0.04). There was no relation to survival rate between T2 and T3, squamous and adenocarcinoma, and between lobectomy and pneumonectomy. Most of our patients died of post-operative metastasis (52%), related to the large size of the tumor.
authors.forename: J P
authors.initials: JP
authors.lastname: Gamondes
authors.forename: J Y
authors.initials: JY
authors.lastname: Bonnefoy
authors.forename: O
authors.initials: O
authors.lastname: Jegaden
authors.forename: V
authors.initials: V
authors.lastname: Trillet
authors.forename: P
authors.initials: P
authors.lastname: Adeleine
authors.forename: C
authors.initials: C
authors.lastname: Lablanche
authors.forename: J
authors.initials: J
authors.lastname: Brune
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011379:Prognosis
vernacular_title: A propos du traitement chirurgical de quarante-huit cancers bronchiques périphériques primitifs, non à petites cellules, de taille égale ou supérieure à 8 cm. Etude des facteurs pronostiques et survie à cinq ans.