title: Pharmacokinetics of disodium clodronate after daily intravenous infusions during five consecutive days.
abstract: The pharmacokinetics of disodium clodronate was studied in six patients, three females and two males with Paget's disease and one male patient with prostatic cancer. The drug was given at a dose of 300 mg/day as a 3-hour infusion for 5 consecutive days. The concentration of the drug in serum and urine was measured by a gas chromatographic method. The peak concentration of disodium clodronate in serum was 5.7 +/- 1.0 micrograms/ml (means +/- SD) for the males and 10.1 +/- 2.8 micrograms/ml for the females. The elimination half-lives of the drug were 0.76 +/- 0.47 h and 1.79 +/- 0.26 h and the total clearances 18.2 +/- 3.3 l/h and 11.5 +/- 1.9 l/h, respectively. During the fifth day both sexes showed similar mean clearances of 11.9 +/- 1.3 l/h and 11.1 +/- 2.5 l/h and half-lives of about 2 h. The renal clearances was 7.3 +/- 0.5 l/h and 5.9 +/- 0.4 l/h for males and females, respectively. The mean urinary excretion of disodium clodronate during the 5-day period was 59.5% in the male patients and 56.0% in the female patients. We concluded that the slow infusion may increase the accumulation of clodronate in the body causing a higher clearance and a lower urine excretion of the drug than seen in earlier studies with faster infusions.
authors.affiliation: Biomedical Research Center, Huhtamäki Oy Leiras, Turku, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Hanhijärvi
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: M
authors.initials: M
authors.lastname: Karlsson
authors.forename: L
authors.initials: L
authors.lastname: Lauren
mesh_terms: D000368:Aged; D002849:Chromatography, Gas; D004002:Clodronic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004164:Diphosphonates / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D004164:Diphosphonates; D004002:Clodronic Acid