Ultrastructural and histochemical assessment of proximal renal tubule in rats during administration of lithium carbonate.
Rat kidney was studied histochemically and in electron microscope during administration of lithium carbonate for 14 days in doses of 4 mmol/l. Morphological examination demonstrated signs of damage exclusively to the epithelial cells in the proximal tubule. Histochemical examination demonstrated a major reduction of the reactions for succinate dehydrogenase and cytochrome oxidase. No difference was found in the intensity of the reaction for alkaline phosphatase and Ca-ATPase during lithium treatment as compared to controls. Additional observation demonstrated, only in histological examination, an increased number of cells of the macula densa.
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D000818:Animals; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D008094:Lithium / Q000633:toxicity*; D016651:Lithium Carbonate; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D016651:Lithium Carbonate; D008094:Lithium