Pharmacological studies on dithranol-induced irritative dermatitis in mice.
The effects of different pharmacological substances on dithranol-induced irritative dermatitis were studied in mice. Pretreatment of the animals with a specific platelet activating factor (PAF) antagonist, BN 52021, significantly reduced the ear swelling in a dose-dependent manner. The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis. The results provide evidence of the coinvolvement of PAF, prostaglandins, histamine, and reactive oxygen radicals in dithranol-induced irritative dermatitis in mice.
Kemény
L
L
Department of Dermatology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Csató
M
M
Dobozy
A
A
D000818:Animals; D000875:Anthralin; D002974:Clemastine / Q000627:therapeutic use; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D046934:Ginkgolides; D007213:Indomethacin / Q000627:therapeutic use; D007783:Lactones / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D012867:Skin / Q000473:pathology; D013482:Superoxide Dismutase / Q000627:therapeutic use
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D002974:Clemastine; C045856:ginkgolide B; D013482:Superoxide Dismutase; D000875:Anthralin; D007213:Indomethacin