Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment.
Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but were unchanged by lithium treatment, whereas TSH concentrations showed a rapid increase following the introduction of lithium therapy.
Christie
J E
JE
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, U.K.
Whalley
L J
LJ
Hunter
R
R
Bennie
J
J
Fink
G
G
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008094:Lithium / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009481:Neurophysins / Q000097:blood; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D013469:Sulpiride / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood
D006728:Hormones; D009481:Neurophysins; D013469:Sulpiride; D011388:Prolactin; D007986:Luteinizing Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D008094:Lithium; D006854:Hydrocortisone