Fibrinolytic inhibitors from the experimental rat epithelioma.
Guerin epithelioma, a highly metastatic tumour implanted to Wistar rats contains two inhibitors of fibrinolysis which can be detected with the use of zymographic techniques. The first one--with Mr about 48000 forms SDS-stable complex with urokinase. The second--with Mr about 7000 inhibits fibrinolytic and amidolytic activity of plasmin.
Mirowski
M
M
Department of Biochemistry, Medical Academy, Lodz, Poland.
Wierzbicki
R
R
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D000933:Antifibrinolytic Agents / Q000032:analysis* / Q000494:pharmacology; D002277:Carcinoma / Q000032:analysis*; D002863:Chromogenic Compounds; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D008970:Molecular Weight; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000032:analysis*; D009842:Oligopeptides / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014568:Urokinase-Type Plasminogen Activator
D000814:Aniline Compounds; D000933:Antifibrinolytic Agents; D002863:Chromogenic Compounds; D009842:Oligopeptides; C019498:4-nitroaniline; C034172:chromozym PL; D005337:Fibrin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator