Inhibition by amlodipine of activity evoked in isolated human coronary arteries by endothelin, prostaglandin F2 alpha and depolarization.
Amlodipine, a dihydropyridine calcium antagonist has been examined on the rhythmic activity of isolated human coronary arteries. Amlodipine inhibited both the spontaneous rhythmic activity and the rhythmic activity evoked by prostaglandin F2 alpha and endothelin in isolated human coronary arteries. It also inhibited the contraction evoked by potassium depolarization. The action of amlodipine was characterized by slow onset and voltage dependency.
Godfraind
T
T
Département de Chirurgie Cardiaque, Université Catholique de Louvain, Bruxelles, Belgique.
Mennig
D
D
Bravo
G
G
Chalant
C
C
Jaumin
P
P
D017311:Amlodipine; D002121:Calcium Channel Blockers; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000494:pharmacology*; D004594:Electrophysiology; D016232:Endothelins; D004730:Endothelium, Vascular; D006801:Humans; D066298:In Vitro Techniques; D009543:Nifedipine / Q000494:pharmacology; D010210:Papillary Muscles / Q000187:drug effects; D010455:Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation
D002121:Calcium Channel Blockers; D016232:Endothelins; D010455:Peptides; D017311:Amlodipine; D015237:Dinoprost; D009543:Nifedipine; D011188:Potassium