title: Unique reactions of scrotal skin to topical agents.
abstract: Topical agents that do not produce irritant reaction elsewhere on the skin readily produce irritant dermatitis and even ulceration when applied to scrotal skin. As Shelley and Shelley state: "The scrotum must be recognized as a skin area with remarkable permeability. It provides a unique percutaneous doorway for the entrance of drugs into the circulation and is thus uniquely susceptible to toxic and irritant agents."
authors.affiliation: New York University Medical School, New York.
authors.forename: A A
authors.initials: AA
authors.lastname: Fisher
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000536:Aluminum Hydroxide / Q000009:adverse effects; D001252:Astringents / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D006204:Hair Removal / Q000009:adverse effects; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D011033:Podophyllin / Q000009:adverse effects; D012611:Scrotum / Q000187:drug effects*; D013864:Thioglycolates / Q000009:adverse effects
chemical_list: D001252:Astringents; D007509:Irritants; D013864:Thioglycolates; C016213:aluminum oxychloride; D000536:Aluminum Hydroxide; C017487:2-mercaptoacetate; D011033:Podophyllin