[Current developments in the diagnosis and therapy of cytomegalovirus infections].
We describe the case history of a 40-year-old, negroid woman with systemic lupus erythematosus who acquired a severe cytomegalovirus infection on immunosuppression; this infection was successfully treated with ganciclovir. New ideas in the management of CMV infections in immuno-compromised hosts are discussed. The traditional diagnostics are unsatisfactory, antibody detection being very insensitive and culture techniques too slow. A new diagnostic approach by detection of the immediate early antigens of the cytomegalovirus (CMV-IEA) using monoclonal antibodies is fast and reliable (sensitivity 93%, specificity 92%), even in case of immuno-deficiency. Finally we discuss the efficacy of the antiviral agent ganciclovir in the management of severe CMV infections.
Bresser
P
P
Toben
F M
FM
van Son
W J
WJ
Anema
J
J
Beukhof
J R
JR
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D015774:Ganciclovir; D006801:Humans; D017874:Immediate-Early Proteins; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*
D000956:Antigens, Viral; D000998:Antiviral Agents; D017874:Immediate-Early Proteins; D007166:Immunosuppressive Agents; C044582:immediate-early proteins, cytomegalovirus; D015774:Ganciclovir; D000212:Acyclovir
Nieuwe ontwikkelingen in diagnostiek en therapie van cytomegalovirusinfectie.