Modulation of putative preneoplastic foci in exocrine pancreas of rats and hamsters. Interaction of dietary fat and coffee.
The effects of coffee and dietary fat (alone and in combination) on the development of preneoplastic lesions in exocrine pancreas were investigated in rats and hamsters, treated with azaserine or N-nitrosobis(2-oxopropyl)amine, respectively. The animals were given the respective diets (5% or 25% corn oil) and coffee (instead of drinking water) within one week after the treatment with carcinogen. At four months postinitiation, the pancreata were quantitatively examined for the number and size of preneoplastic foci. In rats, coffee alone inhibited growth of acidophilic foci and, moreover, slightly inhibited the positive modulating effect of fat on growth of these foci, pointing to a negative rather than a positive interaction between these two life-style factors. In hamsters, coffee alone enhanced growth of cystic foci, whereas fat alone enhanced growth of ductular foci. An interaction between fat and coffee on pancreatic carcinogenesis in hamsters could not be demonstrated.
Woutersen
R A
RA
Department of Biological Toxicology, TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Van Garderen-Hoetmer
A
A
Bax
J
J
Scherer
E
E
D000818:Animals; D001377:Azaserine; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003069:Coffee / Q000633:toxicity*; D006224:Cricetinae; D004041:Dietary Fats / Q000633:toxicity*; D004347:Drug Interactions; D008297:Male; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D014886:Weaning
D002273:Carcinogens; D003069:Coffee; D004041:Dietary Fats; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine; D001377:Azaserine