Polyamine sensitization in offshore workers handling drilling muds.
Oil-based mud, a complex mixture containing amines in emulsifiers, is used in offshore drilling operations. It is a skin irritant that occasionally gives rise to allergic contact sensitivity. In patch testing patients with allergy to drilling mud, we have identified polyamine (diethylenetriamine and triethylenetetramine) sensitivity in 5 patients. All 5 patients were also allergic to emulsifiers. These emulsifiers are cross-linked fatty acid amido-amines, in which unreacted amine groups are thought to cross-sensitize with these constituent polyamines. Cross-reactivity between ethylenediamine, diethylenetetramine and triethylenetetramine was found in 9 subjects.
Ormerod
A D
AD
Dermatology Department, Aberdeen Royal Infirmary, Foresterhill, UK.
Wakeel
R A
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Mann
T A
TA
Main
R A
RA
Aldridge
R D
RD
D000328:Adult; D002617:Chemical Industry; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D004655:Emulsions / Q000009:adverse effects*; D005029:Ethylenediamines / Q000009:adverse effects; D006801:Humans; D008153:Lubrication; D008297:Male; D008875:Middle Aged; D008899:Mineral Oil / Q000009:adverse effects; D010578:Petroleum; D011073:Polyamines / Q000009:adverse effects*; D014266:Trientine / Q000009:adverse effects
D004655:Emulsions; D005029:Ethylenediamines; D010578:Petroleum; D011073:Polyamines; C005391:diethylenetriamine; C031234:ethylenediamine; D008899:Mineral Oil; D014266:Trientine