title: Cytoprotective effect of plasmin inhibitor on necrotizing agent-induced gastric lesions in rats.
abstract: We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential difference induced by 50% ethanol and 1% ammonia. The protection of gastric mucosa afforded by tranexamic acid and aminocaproic acid was not affected by pretreatment with indomethacin (5 mg/kg). These results suggest that plasmin inhibitor plays an important role in the prevention of gastric deep necrosis following exposure of the stomach to a damaging agent.
authors.affiliation: Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: J K
authors.initials: JK
authors.lastname: Yoo
authors.forename: S
authors.initials: S
authors.lastname: Teramura
authors.forename: M
authors.initials: M
authors.lastname: Inada
authors.forename: H
authors.initials: H
authors.lastname: Saita
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Kusaka
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: T
authors.initials: T
authors.lastname: Miyake
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology; D000641:Ammonia / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014148:Tranexamic Acid / Q000494:pharmacology
chemical_list: D000431:Ethanol; D014148:Tranexamic Acid; D000641:Ammonia; D005341:Fibrinolysin; D015119:Aminocaproic Acid; D007213:Indomethacin