A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.
Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
Juang
J K
JK
Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C.
Huang
H W
HW
Chen
C M
CM
Liu
H J
HJ
D000818:Animals; D004249:DNA Damage; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D008962:Models, Theoretical; D010957:Plasmids; D011283:Pregnenes / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology; D013552:Swine
D011283:Pregnenes; C059043:withangulatin A; D004250:DNA Topoisomerases, Type II