Suppression of primary antibody response in genetically susceptible mice infected with Salmonella typhimurium: restoration by catalase.
Susceptible C57BL/6 mice infected with a temperature-sensitive mutant of Salmonella typhimurium exhibited a marked depression of in vivo and in vitro primary antibody response to sheep erythrocytes which persisted for several weeks. The antibody response to a T-independent antigen (TNP-polyacrylamide) was also depressed. Cell-mixing experiments indicated that spleen cells from infected animals contained adherent suppressor cells and that the functional activity of T and B cells was unaffected. The antibody response of spleen cells from infected mice was restored by the addition of catalase, suggesting that hydrogen peroxide is involved in the mechanism of suppression.
Deschênes
M
M
Laboratoire de Microbiologie, Faculté de Médecine de Paris-Ouest, Garches, France.
Guenounou
M
M
Nauciel
C
C
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002374:Catalase / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D007108:Immune Tolerance; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D012486:Salmonella typhimurium; D012756:Sheep; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006861:Hydrogen Peroxide; D002374:Catalase