Micronucleus test applied in patients with acute leukemia, before and at different intervals during the cytostatic treatment.
The micronucleus test was applied in a group of 36 patients with malignant disease of the blood (acute lymphoblastic leukemia, ALL, and acute non-lymphocytic leukemia, ANLL) in order to evaluate to what extent it may be relevant for the efficiency of the cytostatic treatment. To this end, the test was applied at the onset of the disease (when diagnosed) and at different intervals after initiating the cytostatic therapy. Determination of the incidence of micronucleated cells and immature cells (blasts) at the two moments of the study established a correlation between the frequency of micronucleated cells and blast cells, the response to the anticancerous treatment and survival duration, the data obtained reflecting the prognostic value of the test in some malignant hemopathies.
Mihalache
D
D
Stefănescu
D T
DT
Motoiu
I
I
Constantiniu
L
L
Costache
A
A
Dumitrescu
A
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology*; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology