Interferon receptors and their role in interferon action.
Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.
Grossberg
S E
SE
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226.
Taylor
J L
JL
Kushnaryov
V M
VM
D000818:Animals; D003001:Cloning, Molecular; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism*; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D017471:Receptors, Interferon
D007370:Interferon Type I; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D007371:Interferon-gamma