[Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells].
Activation of the respiratory metabolic channel (F.O.R.), responsible in part for the bactericidal effect, was measured in vitro by a chemoluminescence test on circulating phagocytes. All mycobacteria tested, except for Mycobacterium leprae, induced a significant response. Its effect on lepromatous leprosy pathology is a subject for discussion.
Launois
P
P
Laboratoire d'Immunologie cellulaire, Institut Pasteur de Dakar.
Dieye
A
A
Blum
L
L
Millan
J
J
Sarthou
J L
JL
D005609:Free Radicals; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D008163:Luminescent Measurements; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism; D009161:Mycobacterium / Q000502:physiology; D009166:Mycobacterium leprae / Q000502:physiology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D005609:Free Radicals; D007371:Interferon-gamma; D010100:Oxygen
Activation macrophagique et Mycobacterium leprae: action de l'interféron gamma sur la production de radicaux oxygénés libres (R.O.L.) des cellules phagocytaires.