Chronic progressive multiple sclerosis: changes in phenotype and function of T helper subsets.
We have measured pokeweed mitogen-induced IgG secretion by peripheral blood mononuclear cells obtained from two different groups of progressive multiple sclerosis (MS) patients. MS patients with chronic progressive active disease (CPMS-A) have higher IgG secretion than stable (burnt-out) patients (CPMS-S). We have also measured suppressor cell function and phenotyped the T helper cells of some CPMS-A patients. This group differed from CPMS-S and from controls: they had high IgG secretion, low suppression and their T helper phenotypes showed a high ratio of T helper/inducers over T suppressor/inducers.
O'Gorman
M R
MR
Department of Medicine, University of British Columbia, Vancouver, Canada.
Aziz
T
T
Oger
J
J
D002908:Chronic Disease; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D009103:Multiple Sclerosis / Q000276:immunology*; D010641:Phenotype; D011043:Pokeweed Mitogens; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007074:Immunoglobulin G; D011043:Pokeweed Mitogens