Selective breeding in rats for extreme densities of platelet 3H-imipramine binding sites: evidence against a trait hypothesis.
Some investigators suggest that the number of platelet 3H-imipramine binding sites is genetically determined and that the reduced 3H-imipramine binding observed in some studies of depression represents a trait marker. Others believe that 3H-imipramine binding is state-dependent because 3H-imipramine binding has been reported to normalize after clinical recovery. We used a genetic selection paradigm in rats to approach this question from another direction. While breeding 10 generations of rats, we used either extremely high or extremely low density of platelet 3H-imipramine binding sites as a selection criterion. We were unsuccessful in producing two distinct rat sublines. These data do not support a predominant genetic influence on 3H-imipramine binding.
Gentsch
C
C
University of Basel, Switzerland.
Lichtsteiner
M
M
Feer
H
H
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D005260:Female; D007099:Imipramine / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000235:genetics* / Q000378:metabolism; D012641:Selection, Genetic
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine