title: Multiple steps are required for the induction of tumors by Abelson murine leukemia virus.
abstract: Helper virus-free Abelson murine leukemia virus (A-MuLV) was used to induce monoclonal pre-B-cell tumors in mice. The clonality, patterns of immunoglobulin heavy-chain gene rearrangement, tumorigenicity, and v-abl oncogene expression in individual preleukemic and leukemic colonies were compared. Our results indicate that A-MuLV preleukemic cells with low or undetectable tumorigenic potential give rise to leukemic cells with high tumorigenic potential by a process of subclone selection. The levels of v-abl oncogene product in preleukemic and leukemic cell populations were not significantly different. These results suggest that an additional event(s) unrelated to the level of the v-abl protein product is required for A-MuLV-transformed cells to become fully malignant.
authors.affiliation: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
authors.forename: P L
authors.initials: PL
authors.lastname: Green
authors.forename: D A
authors.initials: DA
authors.lastname: Kaehler
authors.forename: L M
authors.initials: LM
authors.lastname: Bennett
authors.forename: R
authors.initials: R
authors.lastname: Risser
mesh_terms: D000011:Abelson murine leukemia virus / Q000235:genetics / Q000472:pathogenicity*; D000818:Animals; D015139:Blotting, Southern; D002455:Cell Division; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D009856:Oncogene Proteins, Viral / Q000235:genetics; D011289:Preleukemia / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D009856:Oncogene Proteins, Viral