Cholinergic maturation and SCH 23390-induced catalepsy in the male rat pup.
The cataleptogenic effects of the selective dopamine D1 receptor antagonist, SCH 23390, increased between 13 and 17 days of age in male pups. Seventeen- and 21-day-old pups showed equivalent catalepsy. Scopolamine blocked SCH 23390-induced catalepsy in 21-day-old pups but had little effect in 13-day-old pups. The development and cholinergic sensitivity of SCH 23390-induced catalepsy are similar to those seen after D2 or mixed D1/D2 receptor blockade. Cholinergic maturation appears to be an important component in the development of adult-like catalepsy, and the nature of a D1-acetylcholine interaction mediating catalepsy remains to be determined.
Fitzgerald
L W
LW
Department of Psychology, State University of New York, Albany 12222.
Hannigan
J H
JH
D000375:Aging / Q000502:physiology*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology*; D002375:Catalepsy / Q000139:chemically induced* / Q000378:metabolism; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017447:Receptors, Dopamine D1; D012601:Scopolamine / Q000494:pharmacology
D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D012601:Scopolamine