Locomotor effects of amperozide. Antagonism of amphetamine-induced locomotor stimulation.
Amperozide given subcutaneously (0.25 mg/kg) depressed amphetamine-induced locomotor activity by 40%. In the absence of amphetamine (1.5 mg/kg), this dose of amperozide had no effect on locomotor activity during the 60 min test period. Amperozide (0.1-1 mg/kg) dose-dependently decreased the locomotor activity of mice as measured in motron boxes. Only doses of amperozide greater than 0.25 mg/kg resulted in statistically significant (p less than 0.05) decreases in motor activity. Pretreatment of mice with flumazenil (10 mg/kg p.o., 30 min) or bicuculline (2 mg/kg i.p., 10 min) had no effect on amperozide (1 mg/kg)-induced hypomotility. These doses of the drugs had no effect per se. These results suggest that dopaminergic mechanisms might be involved in the amperozide-induced hypomotility.
Egbe
P C
PC
Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*
D010879:Piperazines; D011619:Psychotropic Drugs; C049058:amperozide; D005442:Flumazenil; D003913:Dextroamphetamine; D001640:Bicuculline