Vitamin D3 and calcitonin-induced regulation of calcium and phosphate in rat lens--its significance in cataract formation.
Vitamin D3 in the presence of calcium lactate induced significant hypercalcemia and hyperphosphatemia while calcitonin in the presence of a chelating agent (EGTA) induced hypocalcemia and hypophosphatemia in the rat lens. The physiologic significance of these changes in relation to cataract formation was understood by correlating the ratio of calcium and phosphate in the rat lens with the similar ratio obtained from human cataractous lenses of cortical and nuclear types.
Srivastava
V K
VK
School of Cataract Research, Department of Chemistry, University of Gorakhpur, India.
Srivastava
S K
SK
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D002386:Cataract / Q000209:etiology*; D002762:Cholecalciferol / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D010710:Phosphates / Q000097:blood*; D051381:Rats
D007773:Lactates; D010710:Phosphates; D002762:Cholecalciferol; D019344:Lactic Acid; D004533:Egtazic Acid; D002116:Calcitonin; D002118:Calcium