Baroreceptor control after cervical epidural anesthesia in patients undergoing carotid artery surgery.
Baroreceptor (BR) reactivity was studied in 16 patients scheduled for carotid artery surgery performed under cervical epidural anesthesia with 0.375% bupivacaine (15 mL). In the first seven patients, BR reactivity was assessed by measurement of the slopes of the linear relationship between systolic arterial pressure (SAP) and the RR interval on the electrocardiogram. Alterations of blood pressure (BP) were produced using sequential intravenous (IV) doses of nitroglycerin (NTG; 100 to 200 micrograms) or phenylephrine (PHE; 100 to 200 micrograms), before and 30 minutes after epidural anesthesia. The changes in SAP and heart rate (HR) determined during the four phases of a Valsalva maneuver were evaluated in a second set of measurements before and after cervical epidural blockade. In nine additional patients, a third set of measurements studying BR reactivity after carotid clamping and unclamping was performed in order to assess the effect of carotid handling on BP control. Cervical epidural anesthesia induced moderate decreases in BP (SAP, 150 +/- 18 mmHg before cervical block, 143 +/- 27 mmHg after cervical block, P less than 0.05) and HR (RR, 812 +/- 120 ms before cervical block, 938 +/- 130 ms after cervical block, P less than 0.05). Cervical epidural anesthesia depressed BR reactivity during deactivation as assessed by the decrease in the BR slope after PHE injection (6.6 +/- 4.4 ms/mmHg before cervical block v 2.5 +/- 1.8 ms/mmHg after cervical block, P less than 0.01) and activation as assessed by the changes in SAP and HR during phases II and IV of the Valsalva maneuver.(ABSTRACT TRUNCATED AT 250 WORDS)
Bonnet
F
F
Département d'Anesthésie Réanimation II, Hôpital Henri Mondor, Creteil, France.
Szekely
B
B
Abhay
K
K
Touboul
C
C
Boico
O
O
Saada
M
M
D000368:Aged; D000767:Anesthesia, Epidural; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002045:Bupivacaine / Q000494:pharmacology; D002339:Carotid Arteries / Q000294:innervation* / Q000601:surgery*; D003250:Constriction; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D014636:Valsalva Maneuver; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
D010656:Phenylephrine; D005996:Nitroglycerin; D002045:Bupivacaine