title: Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin.
abstract: 20% azelaic acid cream was compared clinically with it vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne. In a single-blind study of 289 patients with comedonal acne, the topical azelaic acid preparation was compared with 0.05% tretinoin cream over a period of 6 months. In both controlled studies, 20% azelaic acid cream significantly reduced the number of acne lesions and yielded clinically relevant improvement rates. Azelaic acid cream was significantly and substantially more effective than its vehicle, indicating that the dicarboxylic acid itself is an active drug in acne treatment. In the study of comedonal acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. However, azelaic acid cream was better tolerated, causing fewer local side effects than the topical retinoid.
authors.affiliation: Department of Dermatology and Venereology, Medical School, University of Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Katsambas
authors.forename: K
authors.initials: K
authors.lastname: Graupe
authors.forename: J
authors.initials: J
authors.lastname: Stratigos
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D003875:Drug Eruptions / Q000209:etiology; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003998:Dicarboxylic Acids; D014212:Tretinoin; C010038:azelaic acid