Platelet lipid peroxidation in haemodialysis patients: effects of vitamin E supplementation.
In haemodialysis patients, increased concentrations of malonyldialdehyde and decreased vitamin E content indicate lipid peroxidation in the platelets from oxidative damage. The same process has been described in red blood cells and in mononuclear cells in peripheral blood. However, platelet aggregation is within normal limits and does not change after treatment with vitamin E. On the other hand vitamin E supplementation reverts completely the biochemical abnormality of the platelets.
Taccone-Gallucci
M
M
Clinica Chirurgica, II Universita' di Roma, Italy.
Lubrano
R
R
Del Principe
D
D
Menichelli
A
A
Giordani
M
M
Citti
G
G
Morosetti
M
M
Meloni
C
C
Mazzarella
V
V
Meschini
L
L
D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use*
D014810:Vitamin E; D008315:Malondialdehyde