title: Cytogenetic studies in 11 patients with small cell carcinoma of the lung.
abstract: Small cell carcinoma of the lung has reportedly been associated with structural abnormalities of the short arm of chromosome 3, but most of the previous studies were done on long-term cultures that involved cell lines. In the current study, we investigated the chromosome abnormalities in specimens from primary lung tumors grown in short-term cultures. Cytogenetic studies were done in 11 patients with small cell carcinoma of the lung, and a chromosomally abnormal clone was observed in each tumor. An abnormality of chromosome 3 was observed in six of these tumors.
authors.affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
authors.forename: P A
authors.initials: PA
authors.lastname: De Fusco
authors.forename: S
authors.initials: S
authors.lastname: Frytak
authors.forename: R J
authors.initials: RJ
authors.lastname: Dahl
authors.forename: L H
authors.initials: LH
authors.lastname: Weiland
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
authors.forename: G W
authors.initials: GW
authors.lastname: Dewald
mesh_terms: D000368:Aged; D000782:Aneuploidy; D018288:Carcinoma, Small Cell / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic