[Potential difference of the gastric mucosa in gastroduodenal disease. Relation with endoscopical and histologic findings].
Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to record potential differences. Biopsies were taken from gastric antrum and body and potential differences were related to endoscopic and histologic findings. Maximal values of -29.2 + 2 and -22.2 + 1.6 for body and antrum, respectively, were found in normals. Lowest values (-19.4 + 1.4 and -14.3 + 1.5, respectively) were found in gastric ulcer, with intermediate values for the other conditions. Normal histologic findings were associated to potentials of -31 + 2 and -20 + 3.1 whereas lower values were recorded in patients with moderate or severe atrophic changes. Our findings suggest a relation between mucosal atrophy and lower transmucosal potential differences.
Defilippi
C
C
Morales
A
A
Smok
G
G
Angelo
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000503:physiopathology*; D005756:Gastritis / Q000473:pathology / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D008875:Middle Aged; D010437:Peptic Ulcer / Q000473:pathology / Q000503:physiopathology
Diferencia de potencial de la mucosa gástrica en patología gastroduodenal. Relación con los hallazgos endoscópicos e histológicos.