Natriuretic and diuretic effects of endothelin in isolated perfused rat kidney.
In an attempt to clarify the pathophysiological role of endothelin (ET), a novel vasoconstrictor peptide, we administered this peptide into the medium of isolated perfused rat kidney (IPK). ET increased renal vascular resistance by 53%, and reduced inulin clearance by 29% in IPK at a higher concentration of 500 PM. However, fractional excretion of sodium and urine flow rate were increased by 160% and 109%, respectively. These findings suggest that ET modulates the tubular sodium reabsorption as well as the renal hemodynamics.
Nitta
K
K
Department of Medicine, Tokyo Women's Medical college, Japan.
Naruse
M
M
Sanaka
T
T
Tsuchiya
K
K
Naruse
K
K
Zeng
Z P
ZP
Demura
H
H
Sugino
N
N
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004727:Endothelium; D007444:Inulin / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
D009320:Atrial Natriuretic Factor; D007444:Inulin