title: No evidence of platelet activation during atrial pacing in subjects with stable angina.
abstract: Platelet behaviour (activation) in ischemic heart disease (stable angina) during pacing-induced tachycardia was studied. ECG was recorded during the trial. Ischemic heart disease (IHD) subjects had 75% or more narrowing of the luminal diameter of a coronary artery, demonstrated by coronary angiography. Eight subjects needing cardiac catheterism because of supraventricular rhythm disturbances with no evidence of IHD were studied as controls. Beta-thromboglobulin (beta-tg) and platelet factor 4 (PF4) were studied as platelet activation markers; beta-tg and PF4 were evaluated before atrial pacing in peripheral venous blood and, by catheterism, before and at maximum pacing rate in coronary venous sinus (CVS) and in ascending aorta (AA). Catheterism and blood withdrawals were performed in order to reduce platelet activation in vivo. No significant difference in platelet activation between IHD patients and control group in peripheral venous blood were found. No trans-myocardial gradient neither in IHD subjects nor in controls were observed. In conclusion, no platelet activation in IHD patients during pacing-induced tachycardia could be observed.
authors.forename: M
authors.initials: M
authors.lastname: Bazzan
authors.forename: P
authors.initials: P
authors.lastname: Schinco
authors.forename: F
authors.initials: F
authors.lastname: Orzan
authors.forename: A
authors.initials: A
authors.lastname: Pannocchia
authors.forename: G
authors.initials: G
authors.lastname: Tamponi
authors.forename: A
authors.initials: A
authors.lastname: Pileri
authors.forename: L
authors.initials: L
authors.lastname: Libero
authors.forename: G
authors.initials: G
authors.lastname: Defilippi
authors.forename: A
authors.initials: A
authors.lastname: Brusca
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000502:physiology*; D001620:beta-Thromboglobulin / Q000502:physiology*
chemical_list: D001620:beta-Thromboglobulin; D010978:Platelet Factor 4