Increased alpha-adrenergic responsiveness in idiopathic Raynaud's disease.
In our study of 28 patients with idiopathic Raynaud's disease, the patients had significantly greater digital blood flow responses to intraarterial phenylephrine and clonidine than did normal control subjects. There were no group differences in finger blood flow responses to body heating, reflex cooling, digital ischemia, or to intraarterial tyramine or isoproterenol. There were also no group differences in blood pressure or heart rate during any procedure. These results suggest that patients with idiopathic Raynaud's disease have increased peripheral vascular alpha-adrenergic receptor sensitivity and/or density compared with normal persons.
Freedman
R R
RR
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan.
Sabharal
S C
SC
Desai
N
N
Wenig
P
P
Mayes
M
M
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology; D003080:Cold Temperature; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006358:Hot Temperature; D006801:Humans; D007261:Infusions, Intra-Arterial; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011928:Raynaud Disease / Q000503:physiopathology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D014439:Tyramine / Q000008:administration & dosage / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D010656:Phenylephrine; D007545:Isoproterenol; D003000:Clonidine; D014439:Tyramine