Calcium antagonist. Effect on adhesion formation.
In view of the role of the calcium ion in the inflammatory process, the effect of Diltiazem--a calcium antagonist--on the formation of intraperitoneal adhesions was studied in rats after induced trauma to the uterine serosa. It was found that intraperitoneal application of diltiazem inhibited adhesion formation to some extent, whereas intramuscularly administered Diltiazem did not. A dual effect of calcium antagonists on the formation of adhesions is suggested.
Golan
A
A
Department of Obstetrics and Gynecology, Serlin Maternity Hospital, Hakirya, Tel-Aviv, Israel.
Wexler
S
S
Lotan
G
G
Abramov
L
L
Langer
R
R
David
M P
MP
D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004110:Diltiazem / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000517:prevention & control; D014599:Uterus / Q000601:surgery
D002121:Calcium Channel Blockers; D004110:Diltiazem