title: Muscarinic slow EPSPs in neostriatal and hippocampal neurons in vitro.
abstract: Cholinergic slow excitatory postsynaptic potentials (slow EPSPs) can be elicited by presynaptic tetanic stimulation in brain slices obtained from rat neostriatum or guinea pig hippocampus. Slow EPSPs are generated by a reduction of a K-leak-conductance. In hippocampal neurons slow EPSPs are amplified by the reduction of an outward current termed IAHP through the activation of a second muscarinic receptor subtype. While hippocampal slow EPSPs might be involved in information processing across hippocampal pathways, muscarinic modulation in the neostriatum consists of a presynaptic tuning of nicotinic fast synaptic transmission.
authors.affiliation: Max-Planck-Institut für Psychiatrie, Abteilung Neurophysiologie, Planegg-Martinsried, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Misgeld
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000200:Action Potentials; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010830:Physostigmine / Q000494:pharmacology; D011712:Pyramidal Tracts / Q000502:physiology; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology*
chemical_list: D011976:Receptors, Muscarinic; D001285:Atropine; D010830:Physostigmine; D000109:Acetylcholine