title: Gene regulation and DNA C-value paradox: a model based on diffusion of regulatory molecules.
abstract: The general idea of the model is that regulatory molecules can move stochastically from site to site along DNA and that according to their chromosomal position, genes should have a more or less high probability to be activated (or repressed) during differentiation. In this model the role of non coding DNA is to maintain genes in a relative position that determines what is usually called the "differentiation programme".
authors.affiliation: UER D'Hematologie, LOI CNRS, Institut de Recherche sur les Maladies du Sang, Hopital St Louis, Paris, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Kupiec
mesh_terms: D002454:Cell Differentiation; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D006801:Humans; D008957:Models, Genetic; D013269:Stochastic Processes
chemical_list: D004251:DNA Transposable Elements