Fleroxacin resistance in Escherichia coli.
Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.
Chapman
J S
JS
Roche Research Center, Nutley, New Jersey 07110.
Bertasso
A
A
Georgopapadakou
N H
NH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000096:biosynthesis; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D016576:Fleroxacin; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D002939:Ciprofloxacin; D004250:DNA Topoisomerases, Type II; D016576:Fleroxacin