Cortical dihydropyridine binding sites are unaltered in human alcoholic brain.
The density and affinity of sites labeled by the 1,4-dihydropyridines, [3H]nitrendipine and (+) [3H]PN 200-110, were not significantly different in superior frontal and parietal cortical membranes from alcoholic patients and nonalcoholic control patients. This is in contrast to the increased number of dihydropyridine receptors and increased functional activity of calcium channels reported in brain from rats treated chronically with ethanol and in neural cell lines grown in the presence of ethanol. These results indicate that 1,4-dihydropyridine-sensitive calcium channels (L type) in the brain, despite possible acute changes, are unaltered following long-term ethanol exposure in humans.
Kril
J J
JJ
Department of Pathology, University of Sydney, Australia.
Gundlach
A L
AL
Dodd
P R
PR
Johnston
G A
GA
Harper
C G
CG
D000437:Alcoholism / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004095:Dihydropyridines / Q000378:metabolism*; D006801:Humans; D017275:Isradipine; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000378:metabolism*; D010069:Oxadiazoles / Q000378:metabolism*
D004095:Dihydropyridines; D010069:Oxadiazoles; D009568:Nitrendipine; D017275:Isradipine