In vitro effect of inhibitors on the activity of glucosyltransferase, isolated from human dental plaque.
The enzyme glucosyltransferase plays an important role in plaque formation and growth. Therefore, chemical inhibition of glucosyltransferase may become an effective method for plaque control. In this investigation we have evaluated the effects of some antiplaque substances (chlorhexidine, cetylpiridinium chloride, iodine, sodium fluoride and sodium dodecyl sulfate) on glucosyltransferase activity. Our results revealed that iodine was the most effective inhibitor. Based on in vitro glucosyltransferase inhibition we may suggest that topical iodine could be an auxiliary method for plaque control.
Pinheiro
C E
CE
Poletto
M I
MI
Pinheiro
C R
CR
Negrato
M L
ML
D002648:Child; D003773:Dental Plaque / Q000201:enzymology* / Q000517:prevention & control; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D006801:Humans
D005964:Glucosyltransferases