[Pharmacokinetic interaction of cefixime and 2 antacids. Preliminary results].
A crossover study was undertaken in 8 healthy volunteers to evaluate the pharmacokinetics of cefixime administered orally alone or combined with an antacid. Each subject received successively: cefixime alone, Maalox followed 30 min later by cefixime, then Maalox followed 4 hours later by cefixime and finally Alka-Seltzer followed 30 min later by cefixime. Sixteen blood samples were drawn from 0 to 24 hours after oral administration, and plasma cefixime parameters were determined, using a HPLC assay. Four parameters were used to detect a possible interaction: Cmax, Tmax, AUCO-N and AUCO-alpha. No significant difference was observed between the four parameters. Thus, poor absorption of cefixime when combined with an antacid can be ruled out.
Petitjean
O
O
Département de Pharmacologie-Toxicologie clinique et biologique, Hôpital Avicenne, Bobigny.
Brion
N
N
Tod
M
M
Montagne
A
A
Nicolas
P
P
D000328:Adult; D000863:Antacids / Q000097:blood / Q000493:pharmacokinetics*; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D006801:Humans; D008297:Male
D000863:Antacids; D020682:Cefixime; D002439:Cefotaxime
Etude de l'interaction pharmacocinétique entre le céfixime et deux antiacides. Résultats préliminaires.