Frequency and molecular types of deletional alpha-thalassemia in Egypt.
The frequency of deletional alpha-thalassemia in the Egyptian population was estimated at 0.08 by DNA analysis of a newborn random sample. No alpha 0 determinants were found. The most frequent alpha+ determinant was the -alpha 3.7 type I in association with the medium allele at inter-zeta HVR. The -alpha 4.2 and alpha alpha alpha anti 3.7 arrangements were found at very low frequencies.
Novelletto
A
A
Dipartimento di Biologia, Università Tor Vergata, La Romanina, Rome, Italy.
Hafez
M
M
Di Rienzo
A
A
Felicetti
L
L
Deidda
G
G
el Morsi
Z
Z
al-Tonbary
Y
Y
el-Ziny
M
M
Abd-el-Gelil
N
N
Terrenato
L
L
D002872:Chromosome Deletion; D004262:DNA Restriction Enzymes; D004534:Egypt; D005914:Globins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D005810:Multigene Family; D013789:Thalassemia / Q000453:epidemiology / Q000235:genetics*
D005914:Globins; D004262:DNA Restriction Enzymes