title: Clonal origin of recurrent hepatocellular carcinomas.
abstract: Recurrence of hepatocellular carcinoma after treatment is frequent. To study the clonal origin of the recurrent tumors, we examined five pairs of hepatocellular carcinomas resected from individual hepatitis B surface antigen carriers. Using integrated hepatitis B virus DNA as a marker, tumor clonality was determined by Southern blot analysis. In 2 cases the second tumor contained the same integrated viral DNA as the first one. In the other 3 cases, the clonality of the second cancer differed. We conclude that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.
authors.forename: P J
authors.initials: PJ
authors.lastname: Chen
authors.forename: D S
authors.initials: DS
authors.lastname: Chen
authors.forename: M Y
authors.initials: MY
authors.lastname: Lai
authors.forename: M H
authors.initials: MH
authors.lastname: Chang
authors.forename: G T
authors.initials: GT
authors.lastname: Huang
authors.forename: P M
authors.initials: PM
authors.lastname: Yang
authors.forename: J C
authors.initials: JC
authors.lastname: Sheu
authors.forename: S C
authors.initials: SC
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Hsu
authors.forename: J L
authors.initials: JL
authors.lastname: Sung
mesh_terms: D001483:Base Sequence; D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local
chemical_list: D004279:DNA, Viral