title: [Phosphorylation of cytoplasmic poly (ADP-ribose) polymerase linked to free ribonucleoprotein particles by an associated protein kinase C].
abstract: Considering the eventuality of an interaction between the two post-translational modifications, phosphorylation and ADP-ribosylation, we investigated the possibility of phosphorylation of the mRNP polyADPR polymerase by a protein kinase C associated to these particles. We demonstrated that cytoplasmic poly (ADP-ribose) polymerase associated with ribonucleoprotein particles containing silent mRNA is phosphorylated by a specifically activated endogenous protein kinase C which in turn induces an inhibition of the polymerase activity. In the absence of protein kinase C activators the mRNP polyADPR-P is also phosphorylated but without changes of its enzymatic activity.
authors.affiliation: Centre de Neurochimie, Strasbourg.
authors.forename: C
authors.initials: C
authors.lastname: Chypre
authors.forename: C
authors.initials: C
authors.lastname: Le Calvez
authors.forename: F
authors.initials: F
authors.lastname: Hog
authors.forename: M O
authors.initials: MO
authors.lastname: Revel
authors.forename: M
authors.initials: M
authors.lastname: Jesser
authors.forename: P
authors.initials: P
authors.lastname: Mandel
mesh_terms: D015153:Blotting, Western; D003593:Cytoplasm / Q000201:enzymology; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D010766:Phosphorylation; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; D011065:Poly(ADP-ribose) Polymerases; D011493:Protein Kinase C
vernacular_title: Phosphorylation de la poly (ADP-ribose) polymérase cytoplasmique liée à des particules ribonucléoprotéiques libres par une protéine kinase C associée.