title: A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis.
abstract: A trial of n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis has been conducted over a 5 year period. Ambulant patients (312) with acute remitting disease were randomly allocated to treatment or placebo. Both groups were given dietary advice to increase the intake of n-6 polyunsaturated fatty acids and the treatment group in addition received capsules containing n-3 polyunsaturated fatty acids. Analysis of clinical outcome at the end of 2 years of treatment was made in terms of the duration, frequency and severity of relapses and the number of patients who had improved or remained unchanged. The results showed no significant difference at the usual 95% confidence limits but there was a trend in favour of the group treated with n-3 polyunsaturated fatty acids in all parameters examined.
authors.affiliation: Department of Neurology, University of Newcastle upon Tyne, UK.
authors.forename: D
authors.initials: D
authors.lastname: Bates
authors.forename: N E
authors.initials: NE
authors.lastname: Cartlidge
authors.forename: J M
authors.initials: JM
authors.lastname: French
authors.forename: M J
authors.initials: MJ
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Nightingale
authors.forename: D A
authors.initials: DA
authors.lastname: Shaw
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Woo
authors.forename: S A
authors.initials: SA
authors.lastname: Hawkins
authors.forename: J H
authors.initials: JH
authors.lastname: Millar
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D002214:Capsules; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy*
chemical_list: D002214:Capsules; D004338:Drug Combinations; D005227:Fatty Acids; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid