Experimental infection of rhesus monkeys with SIV isolated from African green monkeys.
To establish an animal model for AIDS, 6 juvenile rhesus monkeys were infected intravenously with cell-free SIVagmTYO-1, 5, or 7. One animal was infected with SIV of known pathogenicity isolated from a sooty mangabey (SIVsmm). The 2 animals infected with TYO-1, 1 of 2 infected with TYO-7 and the 1 infected with SIVsmm seroconverted within 4-8 weeks after infection and infectious virus could be recovered 8-10 or 44 weeks after infection. Three of the 4 seroconverted monkeys developed a persistent lymphadenopathy 12 weeks after infection. Rhesus monkeys infected with SIVagm could serve as a model to study HIV infection and for vaccine trials.
Herchenröder
O
O
Deutsches Primatenzentrum, Göttingen, FRG.
Stahl-Hennig
C
C
Lüke
W
W
Schneider
J
J
Schulze
G
G
Hartmann
H
H
Schmidt
H
H
Tenner-Racz
K
K
Racz
P
P
Hayami
M
M
D000163:Acquired Immunodeficiency Syndrome; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002520:Cercopithecidae; D004195:Disease Models, Animal; D008198:Lymph Nodes / Q000473:pathology; D008251:Macaca; D008253:Macaca mulatta; D012192:Retroviridae Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D014766:Viremia
D000914:Antibodies, Viral