A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.
A double-blind, randomized multi-centre study was performed to evaluate the efficacy of a 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm). One-hundred and twenty-two patients suffering from acne vulgaris were treated with either Zineryt lotion or 2% erythromycin lotion. Acne grading and lesion counts for comedones, papules, pustules, nodules and macules were performed at each visit at 0, 1, 2, 4, 8 and 12 weeks. Treatment with Zineryt lotion was found to be more effective than with 2% erythromycin as regards the reduction in number of the acne lesions and the severity grade of the acne.
Habbema
L
L
Department of Dermatology, University Hospital, Dijkzigt, Rotterdam, The Netherlands.
Koopmans
B
B
Menke
H E
HE
Doornweerd
S
S
De Boulle
K
K
D000085:Acetates / Q000627:therapeutic use*; D019342:Acetic Acid; D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic
D000085:Acetates; D004338:Drug Combinations; D004917:Erythromycin; D019342:Acetic Acid