[Effect of cicletanine on a sudden death model in dogs].
Cicletanine is a new antihypertensive agent. In view of its various pharmacological properties and of the different factors involved in sudden death, cicletanine was tested on an ischaemia-reperfusion model in anaesthesized dogs. In these experiments myocardial reperfusion induced ventricular fibrillation in 87 p. 100 of the cases, where as only 20% of those animals who received cicletanine 20 mg/kg intravenously 15 minutes before the 30 minute coronary occlusion developed ventricular disorders (p less than 0.001 vs controls). Moreover, cicletanine showed good antiarrhythmic activity during occlusion (total number of arrhythmias: 73.0 +/- 23.15 in treated animals, as against 293.4 +/- 40.03 in controls; p less than 0.05). Thus, antihypertensive treatment with cicletanine may prevent some of the cardiovascular risks associated with arterial hypertension.
Guillon
J M
JM
IHB/IPSEN, Le Plessis-Robinson, France.
Thievant
P
P
Braquet
P
P
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications; D003645:Death, Sudden; D004232:Diuretics / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D008297:Male; D008954:Models, Biological; D015425:Myocardial Reperfusion / Q000009:adverse effects; D011725:Pyridines; D014693:Ventricular Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000209:etiology
D000889:Anti-Arrhythmia Agents; D004232:Diuretics; D011725:Pyridines; C038068:cicletanine
Effet du ciclétanine sur un modèle de mort subite chez le chien.