[Increase in the synthesis of histamine by human hematopoietic cells in response to interleukin 3].
Interleukin-3 induces an increase in histamine synthesis, in the murine hematopoietic system. Evidence is given here that this biological activity also exists in the human hematopoietic system (fetal liver, bone marrow and cord blood), and is already detectable after 3 days of culture in the presence of interleukin-3.
Minkowski
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C.N.R.S.-U.A. n. 122, I.N.S.E.R.M. U. n.25, Hôpital Necker, Paris.
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D001854:Bone Marrow Cells; D002469:Cell Separation; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D005312:Fetal Blood / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006632:Histamine / Q000096:biosynthesis*; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000196:embryology; D011994:Recombinant Proteins / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D007377:Interleukin-3; D011994:Recombinant Proteins; D006632:Histamine
Augmentation de la synthèse d'histamine par les cellules hématopoiétiques humaines en réponse à l'interleukine-3.