Cancer induction in mice by 4-hydroxybenzenediazonium sulfate of the Agaricus xanthodermus mushroom.
4-Hydroxybenzenediazonium sulfate (HBD) was administered to Swiss mice by subcutaneous injection at weekly intervals of two or 36 times at 10 or 2 micrograms per gram body weight, respectively. The HBD given 36 times induced tumors of the subcutis in 22% of females and in 22% of males. The corresponding tumor incidences in the untreated controls were 2% in females and 8% in males. Histopathologically, the neoplasms were classified as fibromas, fibrosarcomas, myxosarcomas and rhabdomyosarcomas. The HBD given two times was, however, without tumor-inducing effect. HBD is an ingredient of the Agaricus xanthodermus, a non-cultivable unedible mushroom, which is closely related to the mushroom of commerce Agaricus bisporus. HBD is now the third compound of the diazonium class to exhibit carcinogenic activity.
Toth
B
B
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
Patil
K
K
Taylor
J
J
Stessman
C
C
Gannett
P
P
D000364:Agaricus; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003979:Diazonium Compounds / Q000138:chemical synthesis / Q000633:toxicity*; D005260:Female; D005350:Fibroma / Q000139:chemically induced / Q000473:pathology; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000139:chemically induced / Q000473:pathology; D012727:Sex Characteristics; D012983:Soft Tissue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D003979:Diazonium Compounds; C072609:4-methylbenzenediazonium