Apoptosis in Bowen's disease. An ultrastructural study.
We performed ultrastructural studies of apoptosis (previously referred to as "malignant dyskeratosis") in a case of genital Bowen's carcinoma in which human papillomavirus (HPV) type 33 genome was identified and in two cases of cutaneous Bowen's disease with no detectable viral DNA; herein we present the sequential stages in the development of apoptotic bodies. The apoptotic process in the HPV-containing genital Bowen's disease was similar to that in the cutaneous lesions with no detectable HPV. The presence of a large number of apoptotic bodies in Bowen's disease may be responsible for the slow progression and noninvasive growth of this carcinoma in situ.
Kuligowski
M
M
Department of Dermatology, Warsaw Medical School, Poland.
Dabrowski
J H
JH
Jablonska
S
S
D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000382:microbiology / Q000648:ultrastructure*; D001485:Basement Membrane / Q000648:ultrastructure; D001913:Bowen's Disease / Q000382:microbiology / Q000648:ultrastructure*; D002278:Carcinoma in Situ / Q000648:ultrastructure*; D002294:Carcinoma, Squamous Cell / Q000648:ultrastructure*; D005260:Female; D005838:Genotype; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007382:Intermediate Filaments / Q000648:ultrastructure; D007425:Intracellular Membranes / Q000648:ultrastructure; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D012878:Skin Neoplasms / Q000648:ultrastructure*; D014846:Vulvar Neoplasms / Q000382:microbiology / Q000648:ultrastructure*