Smoking exerts unfavourable effect on human gastroduodenal mucosal endogenous prostacyclin-level.
It seems that endogenous prostacyclin is one of the most important natural protective substances in the (human) gastroduodenal mucosa. According to the observations, in humans there is a definite tendency toward decreased endogenous prostacyclin production in the gastroduodenal mucosa of smokers. This phenomenon draws attention to the possible role of smoking in the development of peptic ulcer disease.
Balint
G A
GA
D011464:Epoprostenol / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D012907:Smoking / Q000009:adverse effects*
D011464:Epoprostenol