Family of human Na+,K+-ATPase genes. Structure of the putative regulatory region of the alpha+-gene.
The primary structure of the putative regulatory region of a gene of the Na+,K+-ATPase multigene family in the human genome has been determined. This region includes the first exon with all of the untranslatable sequence of mRNA and a dozen nucleotides, coding for the first four amino acids of the hypothetic precursor of the alpha+-subunit. The entire region comprises over 1400 bp. The possible role of specific nucleotide blocks within this region in comparison with other genes is discussed.
Sverdlov
E D
ED
Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
Bessarab
D A
DA
Malyshev
I V
IV
Petrukhin
K E
KE
Smirnov YuV
Ushkaryov YuA
Monastyrskaya
G S
GS
Broude
N E
NE
Modyanov
N N
NN
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D003360:Cosmids; D005796:Genes; D005809:Genes, Regulator; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D011817:Rabbits; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*
D000254:Sodium-Potassium-Exchanging ATPase