[Use of erythrocytes for the intravital evaluation of adrenoreceptor function].
Administration of guanethidine (50 mg/kg) decreased the noradrenaline content in adrenergic neurons which led to an augmentation of the effector organ's adrenoreactivity in rats. The affinity of the erythrocytes' beta-adrenoreceptors to propranolol was enhanced and the parameters of their binding the fluorescent probe were changed. The data obtained suggest the possibility of using the erythrocytes for in vivo estimation of functional state of adrenoreactive system in animals and humans.
Sominskiĭ
V N
VN
Berdysheva
L V
LV
Bluma
R K
RK
Kalninia
I E
IE
Okun'
K V
KV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology*; D005456:Fluorescent Dyes; D006145:Guanethidine / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000032:analysis / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D005456:Fluorescent Dyes; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D009638:Norepinephrine; D006145:Guanethidine
Ispol'zovanie éritrotsitov krovi dlia prizhiznennoĭ otsenki funktsional'nogo sostoianiia adrenoretseptorov.