title: Clostridium difficile-associated typhlitis in specific pathogen free guineapigs in the absence of antimicrobial treatment.
abstract: Clostridium difficile (toxin) associated typhlitis was diagnosed in untreated barrier-maintained specific pathogen free guineapigs. It resembled the pathological lesions of antibiotic induced enterocolitis. The possible role of limited colonization resistance to C. difficile provided by mouse enteric microflora in the pathogenesis of the disease is discussed.
authors.affiliation: Department of Animal Supply, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Boot
authors.forename: A F
authors.initials: AF
authors.lastname: Angulo
authors.forename: H C
authors.initials: HC
authors.lastname: Walvoort
mesh_terms: D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000032:analysis*; D002429:Cecal Diseases / Q000382:microbiology / Q000662:veterinary*; D003013:Clostridium / Q000302:isolation & purification*; D003603:Cytotoxins / Q000032:analysis; D006168:Guinea Pigs / Q000382:microbiology*; D007249:Inflammation / Q000382:microbiology / Q000662:veterinary; D012376:Rodent Diseases / Q000382:microbiology; D013047:Specific Pathogen-Free Organisms
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003603:Cytotoxins; C031815:toxB protein, Clostridium difficile