title: The nucleotide sequence of the structural-protein-coding region of foot-and-mouth disease virus serotype SAT3.
abstract: The nucleotide sequence coding for the structural proteins and nonstructural protein P2A has been determined for a foot-and-mouth disease virus (FMDV) isolated in Africa. This virus, serotypically designated SAT3 (South African Territories type 3), shows about 60% homology at the nucleotide level to prototype viruses from the O, A and C serotypes of FMDV. The highest region of variability was shown in structural protein VP1, presumably a consequence of its position on the surface of the virus and its exposure to selection pressure by neutralising antibody. Within this region amino acids (aa) 141-160, which have been shown to represent an immunodominant region in other FMDV serotypes, showed hypervariability as well as the insertion of 5 or 9 additional aa relative to the O1 and C1 serotypes, respectively. In contrast, the sequence of nonstructural protein P2A was completely conserved indicating a probable important role in virus replication.
authors.affiliation: Department of Virology, Wellcome Biotechnology Ltd., Beckenham, Kent, U.K.
authors.forename: A L
authors.initials: AL
authors.lastname: Brown
authors.forename: R O
authors.initials: RO
authors.lastname: Campbell
authors.forename: B E
authors.initials: BE
authors.lastname: Clarke
mesh_terms: D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D005075:Biological Evolution; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping; D014764:Viral Proteins / Q000235:genetics*; D015678:Viral Structural Proteins
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins; D015678:Viral Structural Proteins; D004247:DNA