title: The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.
authors.affiliation: Beecham-Wülfing Clinical Pharmacology Research Institute, Neuss, Federal Republic of Germany.
authors.forename: W H
authors.initials: WH
authors.lastname: Greb
authors.forename: G
authors.initials: G
authors.lastname: Buscher
authors.forename: H D
authors.initials: HD
authors.lastname: Dierdorf
authors.forename: F E
authors.initials: FE
authors.lastname: Köster
authors.forename: D
authors.initials: D
authors.lastname: Wolf
authors.forename: G
authors.initials: G
authors.lastname: Mellows
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D002927:Cimetidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004790:Enzyme Induction / Q000187:drug effects; D004798:Enzymes / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D017374:Paroxetine; D010634:Phenobarbital / Q000494:pharmacology*; D010880:Piperidines / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*
chemical_list: D000928:Antidepressive Agents; D004798:Enzymes; D010880:Piperidines; D012702:Serotonin Antagonists; D017374:Paroxetine; D002927:Cimetidine; D010634:Phenobarbital