[Effect of delta sleep-inducing peptide, anticonvulsant preparations and nicotinamide on generalized seizure activity].
The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice. It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol, bicuculline and picrotoxin and also resulted in a suppression of seizure severity of corazol and bicuculline induced seizures. Anticonvulsant action of DSIP was evident under the condition of the mild severity seizures development. The effect of DSIP was mostly pronounced in range of its doses from 10 to 100 mcg/kg. DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
Makul'kin
R F
RF
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003292:Convulsants / Q000494:pharmacology; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009536:Niacinamide / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D003292:Convulsants; D009536:Niacinamide; D003701:Delta Sleep-Inducing Peptide
Vliianie del'ta-sonindutsiruiushchego peptida, protivosudorozhnykh preparatov i nikotinamida na generalizovannuiu sudorozhnuiu aktivnost'.