title: [Use of a new preparation of flunarizine in patients with peripheral obliterating arteriopathy at the second stage. Controlled clinical study].
abstract: The authors report a randomised double-blind clinical study on the efficacy and tolerability of flunarizine. Two groups of patients with obliterating peripheral arterial disease (stage II) were treated for 3 months either with 10 mg flunarizine or with placebo and were examined monthly as to subjective symptoms, laboratory and instrumental parameters. Findings were evaluated by analysis of variance and Student's t-test. After three months, the flunarizine group had a greater increase of the distance walked before the onset of claudication and of maximum post-ischemic blood flow. No changes were observed in laboratory tests and central hemodynamics. The score of subjective symptoms was improved in the flunarizine treated group. Tolerance was good, side effects requiring withdrawal of treatment were not observed.
authors.forename: M
authors.initials: M
authors.lastname: Guerrini
authors.forename: D
authors.initials: D
authors.lastname: Pieragalli
authors.forename: V
authors.initials: V
authors.lastname: De Franco
authors.forename: T
authors.initials: T
authors.lastname: Di Perri
mesh_terms: D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use*; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012039:Regional Blood Flow
chemical_list: D005444:Flunarizine
vernacular_title: Impiego di una nuova preparazione di flunarizina in pazienti con arteriopatia obliterante periferica al secondo stadio. Studio clinico controllato.