Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats.
The comparative effect of intracerebral injection of 2-APH, a selective antagonist for N-methyl-D-aspartate (NMDA) receptors, into the substantia innominata (SI) and the amygdala (AM) of AM-kindled rats was examined. The intra-SI injection (ipsilateral to the kindled AM) induced a transient incoordination followed by immobility with loss of the rightening reflex, beginning at about 5 min following the injection and lasting for about 3 h. When the animals were stimulated at the previously established generalized seizure triggering threshold (GST) 45 min after the injection, the kindled seizure regressed to earlier stages although the afterdischarge (AD) duration remained unchanged. At 24 h, kindled seizure was readily activated at the GST. When 2-APH was injected into the kindled AM, no behavioural change occurred but AM stimulation at the GST failed to produce AD 45 min after the injection. Kindled seizure could be elicited, however, when the stimulus intensity was increased. This elevation of the GST lasted for 1-18 days. The findings suggest that NMDA receptors in the AM and SI play a differential role in AM seizure initiation and propagation, respectively. They also provide further support to the role presumed to be played by the SI in transforming the limbic seizure into motor seizure.
Mori
N
N
Division of Neurosciences, University of British Columbia, Vancouver, Canada.
Wada
J A
JA
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000378:metabolism / Q000503:physiopathology*; D013377:Substantia Innominata / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*
D000596:Amino Acids; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid