Premedication determines the circulatory responses to rapid sequence induction with sufentanil for cardiac surgery.
Thirty-three patients undergoing elective aortocoronary bypass were allocated randomly to receive morphine 0.1 mg kg-1 i.m. and either lorazepam 50 micrograms kg-1 by mouth or hyoscine 6 micrograms kg-1 i.m. before rapid sequence induction of anaesthesia with sufentanil 5 micrograms kg-1 i.v.and suxamethonium 1 mg kg-1 i.v. Following induction and tracheal intubation, patients premedicated with hyoscine had a significantly higher mean heart rate, mean arterial pressure, cardiac index and left ventricular stroke-work index than patients premedicated with lorazepam. The incidence of new myocardial ischaemia was low in both groups.
Butterworth
J F
JF
Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Bean
V E
VE
Royster
R L
RL
D000771:Anesthesia, Intravenous; D000777:Anesthetics; D001026:Coronary Artery Bypass; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D011229:Preanesthetic Medication; D012601:Scopolamine / Q000494:pharmacology; D017409:Sufentanil
D000777:Anesthetics; D017409:Sufentanil; D012601:Scopolamine; D008140:Lorazepam; D005283:Fentanyl