[Experience with anti-viral hepatitis B vaccine at an institution for handicapped children].
This study, conducted in an institute for handicapped children, is part of an overall effort to extend the anti-HBV vaccine to all high risk categories. Out of 50 patients, 24 (48%) registered negative results for all HBV markers. Twenty-three of these 24 (95.8%) were vaccinated with the Hevac-B Pasteur vaccine s.c. Of 66 employees tested, 51 resulted negative for all HBV markers (77.3%). Of these, 45 (88.2%) were vaccinated: 20 with Hevac-B vaccine s.c., 25 with HBVAX vaccine i.m. via intragluteal injection. Of the 42 who completed the study with Hevac-B, 41 showed an antibody response greater than or equal to 10 mUI (serum conversion of 97.6%). Of the 25 subjects vaccinated with HBVAX, 17 showed an immunological antibody response greater than or equal to 10 mUI (serum conversion of 68%) (p less than 0.001). This differing effectiveness is probably due to the method of injection used in administering HBVAX. It should also be noted that an intense health-education program, stressing high sanitary standards, was instrumental to the project.
Biadaioli
R
R
Losco
D
D
Buonamici
C
C
Mazzotta
F
F
Di Pietro
M
M
Ulivelli
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006782:Hospitals, Special; D006801:Humans; D008875:Middle Aged; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines
Esperienza di vaccinazione anti-epatite virale di tipo B in un istituto per bambini handicappati.