title: [Increase of vertebral bone density in heavy drinkers of mineral water with a high fluoride content].
abstract: The mineral density of bone (MDB) was measured by dualphoton absorptiometry in the lumbar vertebrae of 23 healthy volunteers who consumed large amounts of a mineral water with high fluoride content (8.5 mg/l). The subjects studied had ingested a minimum of 0.75 litre of this water each day for 5 years or more. None of them had a history of pain in the bones or spontaneous fracture. MDB was found to be significantly higher in these subjects than in age - and sex-matched controls, and particularly high in those who were older than 60 years. There was positive correlation (r = 0.61, p less than 0.02) between MDB and mineral water consumption index. Serum levels of osteocalcin - a marker of bone formation - and urinary fluoride levels were significantly higher in drinkers of St-Yorre water than in controls. These data suggest that prolonged consumption of this mineral water by subjects without renal impairment might protect against the risk, increasing with age, of vertebral osteoporosis.
authors.affiliation: INSERM Unité 234, Hôpital Edouard Herriot, Lyon.
authors.forename: P J
authors.initials: PJ
authors.lastname: Meunier
authors.forename: M
authors.initials: M
authors.lastname: Femenias
authors.forename: F
authors.initials: F
authors.lastname: Duboeuf
authors.forename: M C
authors.initials: MC
authors.lastname: Chapuy
authors.forename: P D
authors.initials: PD
authors.lastname: Delmas
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D004326:Drinking; D005260:Female; D005457:Fluoridation; D005459:Fluorides / Q000032:analysis; D006801:Humans; D008159:Lumbar Vertebrae / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000517:prevention & control
chemical_list: D008900:Mineral Waters; D015675:Osteocalcin; D005459:Fluorides
vernacular_title: Augmentation de la densité osseuse vertébrale chez des grands buveurs d'une eau minérale riche en fluor.