Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l. This is the first case in which severe allopurinol hypersensitivity occurred despite a simultaneous plasma oxypurinol concentration within recommended levels (below 100 mumol/l).
Puig
J G
JG
Department of Internal Medicine, Universidad Autónoma, Madrid, Spain.
Casas
E A
EA
Ramos
T H
TH
Michán
A A
AA
Mateos
F A
FA
D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D008297:Male; D010117:Oxypurinol / Q000097:blood*; D011743:Pyrimidines / Q000097:blood*
D011743:Pyrimidines; D000493:Allopurinol; D010117:Oxypurinol