Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres.
The excitotoxic action of N-methyl-D-aspartate (NMDA) and of kinase (KA) has been assessed by measuring glutamic acid decarboxylase (GAD) and choline acetyltransferase (ChAT) activity in the rat striatum 5 days after focal microinjections of NMDA or KA. Prior unilateral lesioning of the nigrostriatal dopaminergic pathway by focal injection of 6-hydroxydopamine decreases the excitotoxic effect of NMDA and of KA.
Chapman
A G
AG
Department of Neurology, Institute of Psychiatry, London, U.K.
Dürmuller
N
N
Lees
G J
GJ
Meldrum
B S
BS
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D006892:Hydroxydopamines; D007608:Kainic Acid / Q000633:toxicity*; D016202:N-Methylaspartate; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D006892:Hydroxydopamines; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016627:Oxidopamine; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D007608:Kainic Acid; D004298:Dopamine