Lung pathogenesis. VIII. Relationships between alveolar surfactant disorders and development of lung diseases.
The new data concerning the structure and dynamics of the alveolar surfactant, its phospholipid and apoprotein components and their synthesis, storage and secretion by the large granular alveolocytes, the formation and disconnection of lipoprotein complexes, their disorders and pathological relationships were analysed in order to discern the possibility of a more or less important pathogenetic role in the onset and development of lung diseases. Sometimes, surfactant disorders appeared as epiphenomena, like in pulmonary edemas; at other times, they behaved as a turn plate enhancing and centering the development of alveolar lipoproteinosis, microlithiasis alveolaris, hyaline membrane disease of newborns and the adult respiratory distress syndrome. Focusing the pathogenesis on the surfactant disorders and on their causes, a unification of mechanisms became possible with the increase in complexity of processes by the intervention of other complicating factors, mainly the self-perpetuating ones.
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D000818:Animals; D001059:Apoproteins / Q000378:metabolism; D006801:Humans; D008065:Lipoid Proteinosis of Urbach and Wiethe / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008171:Lung Diseases / Q000209:etiology* / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000502:physiology*
D001059:Apoproteins; D008074:Lipoproteins; D011663:Pulmonary Surfactants