Determination of tissue type plasminogen activator in the glomeruli of patients with IgA nephropathy.
The detection, by immunofluorescence, of tissue type plasminogen activator (t-PA) in the glomeruli of 50 patients with IgA nephropathy was described. Patients with t-PA deposits revealed a higher frequency in the glomerular deposition of fibrin and/or fibrinogen than did patients without t-PA deposits. There also was a distinct relationship between the level of serum t-PA and the degree of renal tissue injury in patients with glomerular t-PA deposits. It was concluded that the deposition of t-PA along with fibrin and/or fibrinogen might reduce the effectiveness of fibrinolysis in the glomeruli of patients with IgA nephropathy.
Garcia
G
G
Department of Nephrology, IMSS, Mexico City, Mexico.
Miura
M
M
Nomoto
Y
Y
Sakai
H
H
D000328:Adult; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000378:metabolism*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000378:metabolism* / Q000652:urine
D005337:Fibrin; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator