Expression of pregnancy specific beta 1-glycoprotein gene in human placenta and hydatiform mole.
Transcriptional studies of the placental protein Pregnancy Specific beta 1-Glycoprotein (SP1 or PS beta G) gene with a cDNA probe in Northern blot analysis showed 15-20 folds mRNA increase in term placenta compared with early placenta and hydatiform mole. This value parallels the SP1 amount translated in wheat germ cell-free system. We conclude that SP1 biosynthesis is regulated at transcriptional level during placental development and a similar mechanism would occur in hydatiform mole which is a hyperplastic trophoblast tumor.
Bocco
J L
JL
Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba.
Panzetta
G
G
Flury
A
A
Patrito
L C
LC
D010582:Bacteriophage lambda / Q000235:genetics; D015152:Blotting, Northern; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010920:Placenta; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000302:isolation & purification; D014158:Transcription, Genetic
D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D012333:RNA, Messenger