title: [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne].
abstract: 20% azelaic acid cream was compared clinically with its vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne. It was found that the azelaic acid treatment significantly reduced inflamed and non-inflamed lesions and yielded clinically relevant improvement rates. Its action was significantly more effective than its vehicle. In the study of comedo acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. However azelaic acid cream was better tolerated, causing fewer local side effects than the tretinoin.
authors.forename: B
authors.initials: B
authors.lastname: Giannotti
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003879:Dermatologic Agents / Q000008:administration & dosage*; D003998:Dicarboxylic Acids / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D009824:Ointments; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage
chemical_list: D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D009824:Ointments; D014212:Tretinoin; C010038:azelaic acid
vernacular_title: Esperienze cliniche nazionali ed internazionali con una crema a base di acido azelaico nel trattamento dell'acne comedonica.