The efficacy of the combination of teicoplanin or flucloxacillin with netilmicin in the treatment of Staphylococcus aureus bacteraemia.
Twenty one patients with serious Staphylococcus aureus infection and bacteraemia were randomized prospectively to receive either teicoplanin and netilmicin or flucloxacillin and netilmicin. After at least 48 h of treatment serum samples were collected for the determination of trough and peak antibiotic concentrations, the serum killing level and the serum bactericidal rate. With the help of a severity-of-disease scoring system (APACHE II) the clinical efficacy of antimicrobial therapy was assessed. Eighteen patients were evaluable. The clinical results and the results of the serum assays suggest that treatment with teicoplanin or flucloxacillin, combined with netilmicin, is a safe approach in patients with bacteraemia caused by S. aureus.
Degener
J E
JE
Department of Clinical Microbiology, University Hospital Rotterdam, The Netherlands.
Vogel
M
M
Michel
M F
MF
Mutsaers
M M
MM
Hop
W C
WC
D000328:Adult; D003023:Cloxacillin / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005436:Floxacillin / Q000627:therapeutic use*; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D017334:Teicoplanin
D006020:Glycopeptides; D005436:Floxacillin; D009428:Netilmicin; D017334:Teicoplanin; D003023:Cloxacillin