Rabbit plasma fibronectin levels associated with Staphylococcus aureus enterotoxin B: an acute-phase reaction.
Variation in fibronectin (Fn) levels and white blood cell counts (WBC) following staphylococcal enterotoxin B (SEB) or SEB + cryoprecipitate containing Fn challenge was studied in New Zealand white rabbits. Increased plasma Fn levels were observed 2 h after the intravenous injection of SEB and peaked at 48-72 h (from a mean level 194.6 +/- 4.5 micrograms/ml prechallenge Fn level to a 72-hour postchallenge mean level of 407.9 +/- 25.4 micrograms/ml). Fn levels then decreased over the succeeding 5 days to approximately prechallenge levels. The total WBC count decreased by 88% within 2 h after the SEB injection. A slow increase in circulatory WBC was observed over the next 24 h. SEB caused an increase in plasma Fn levels and decreased WBC counts with lymphopenia that was followed by a normal lymphocyte count within 5 days. These data suggest that an acute-phase reaction was induced by interleukin-1. Fn prophylaxis provided no change in clinical signs when given at the time of SEB injection.
Bawdon
R E
RE
University of Texas Southwestern Medical Center, Dallas.
Davis
L E
LE
Little
B B
BB
D000210:Acute-Phase Reaction / Q000209:etiology*; D000818:Animals; D004347:Drug Interactions; D004768:Enterotoxins / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005353:Fibronectins / Q000097:blood* / Q000494:pharmacology; D007249:Inflammation / Q000209:etiology*; D007958:Leukocyte Count / Q000187:drug effects*; D008214:Lymphocytes; D009504:Neutrophils; D011817:Rabbits; D013997:Time Factors
D004768:Enterotoxins; D005353:Fibronectins; C031818:enterotoxin B, staphylococcal