Effects of cisapride on ano-rectal sphincter function.
To investigate the effects of cisapride, a motility-inducing agent, on ano-rectal sphincter functions, standard manometry was performed in 10 healthy male volunteers after 5 days on a 20-mg dose of cisapride in a placebo-controlled double-blind randomized crossover fashion. All subjects kept stool diaries during the experiment. Cisapride significantly increased stool frequency by adding soft and liquid stools; in addition, anal resting pressure was reduced with cisapride in seven of the 10 subjects; mean resting pressure decreased by 16%, while all other measurements were not altered. This suggests that cisapride may act directly on the smooth muscle of the internal anal sphincter. It also supports the view that enhanced defaecation in chronic constipation induced by cisapride may not be achieved by propulsive motor activity in the colon but also by a decreased anal sphincter tone.
Enck
P
P
University Hospital, Department of Internal Medicine, Düsseldorf, FRG.
Arping
H G
HG
Engel
S
S
Bielefeldt
K
K
Erckenbrecht
J F
JF
D000328:Adult; D001003:Anal Canal / Q000187:drug effects*; D020117:Cisapride; D003672:Defecation / Q000187:drug effects; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008365:Manometry; D010465:Perception / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride