Influence of drugs and ionic gradients on gastric secretory epithelium in vitro.
The first part of the paper is devoted to the description of the data acquisition system for studies on epithelial membranes using a process-control computer ECAROM connected to the usual two half-chambers device for epithelial transport studies in vitro. The second part presented the results obtained in several types of experiments concerning the effect of drugs (histamine, acetazolamide) and ionic gradients (K+, Cl-, H+) on the potential difference and/or acid secretion rate.
Mihalas
G I
GI
Department of Biophysics, Traian Vuia Polytechnical Institute, Timişoara, Romania.
Simon
Z
Z
Coifan
V
V
D000086:Acetazolamide / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D002712:Chlorides / Q000493:pharmacokinetics / Q000494:pharmacology*; D003625:Data Collection; D001330:Electronic Data Processing; D004848:Epithelium / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D006632:Histamine / Q000494:pharmacology*; D006859:Hydrogen / Q000493:pharmacokinetics / Q000494:pharmacology*; D007477:Ions; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D011188:Potassium / Q000493:pharmacokinetics / Q000494:pharmacology*; D011895:Rana ridibunda
D002712:Chlorides; D007477:Ions; D006859:Hydrogen; D006632:Histamine; D000086:Acetazolamide; D011188:Potassium