[A case of Hodgkin's disease exhibiting erythrodermia probably due to allergic reaction to vinca alkaloids].
A 58-year-old man with Hodgkin's disease exhibited erythrodermia due to allergic reaction to vincristine sulfate (VCR) and vindesine sulfate (VDS). However, chemotherapy could be continued by changing VCR and VDS to etoposide without allergic symptom. Clinical observation strongly suggested that erythrodermia was due to the use of vinca alkaloids in this patient. Hematological and neurological side effects have been well known for VDS and VCR, but erythrodermia has not yet been reported as being caused by these agents. It is often difficult to differentiate drugs as a cause of an allergic reaction when several drugs are used together. Therefore, it is important to collect all the cases showing the effects of drugs.
Matsumoto
N
N
First Dept. of Internal Medicine, School of Medicine, University of Tokushima.
Yoshimoto
K
K
Okagawa
K
K
Kosaka
M
M
Saito
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology*; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects*
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014751:Vindesine; D011241:Prednisone