The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.
Greb
W H
WH
Beecham-Wülfing Clinical Pharmacology Research Institute, Neuss, Federal Republic of Germany.
Buscher
G
G
Dierdorf
H D
HD
Köster
F E
FE
Wolf
D
D
Mellows
G
G
D000328:Adult; D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D002927:Cimetidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004790:Enzyme Induction / Q000187:drug effects; D004798:Enzymes / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D017374:Paroxetine; D010634:Phenobarbital / Q000494:pharmacology*; D010880:Piperidines / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*
D000928:Antidepressive Agents; D004798:Enzymes; D010880:Piperidines; D012702:Serotonin Antagonists; D017374:Paroxetine; D002927:Cimetidine; D010634:Phenobarbital