Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.
Esumi
H
H
Biochemistry Division, National Cancer Center Research Institute, Tokyo.
Ohgaki
H
H
Kohzen
E
E
Takayama
S
S
Sugimura
T
T
D000818:Animals; D005260:Female; D007093:Imidazoles; D008223:Lymphoma / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens
D007093:Imidazoles; D009153:Mutagens; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine