Role of acid base balance and mucosal blood flow in alkaline secretion of rabbit duodenum.
Alkaline secretion of the duodenal mucosa is thought to be an important protective mechanism against luminal acid. This study was designed to investigate the role of acid base balance and mucosal blood flow for duodenal alkaline secretion in an in vivo preparation. Segments of proximal duodenum of anaesthetised New Zealand white rabbits were canulated and perfused in situ. Alkaline secretion (pH-stat method), mucosal blood flow, arterial pO2, pCO2 and HCO-3 were measured. We have found that metabolic alkalosis and glucagon led to a significant increase in alkaline secretion, while metabolic acidosis and vasopressin significantly reduced it. Mucosal blood flow was significantly changed under glucagon and vasopressin.
Vattay
P
P
University Clinic of Surgery, Szeged, Hungary.
Wenzl
E
E
Feil
W
W
Starlinger
M
M
Schiessel
R
R
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000468:Alkalies / Q000378:metabolism; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D004386:Duodenum / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D014667:Vasopressins / Q000494:pharmacology
D000468:Alkalies; D001639:Bicarbonates; D000643:Ammonium Chloride; D014667:Vasopressins; D005665:Furosemide; D017693:Sodium Bicarbonate; D005934:Glucagon; D012964:Sodium