Atrial natriuretic peptides and tubular sodium handling during normal daily life in men.
The relationship between segmental renal tubular sodium handling (using the renal clearance of ingested lithium as a marker of proximal tubular sodium handling) and circulating plasma levels of atrial natriuretic factor (ANF) was studied in a sample of 295 untreated men drawn from a male population at work under their usual living conditions. Plasma ANF was positively and significantly related to sodium excretion at the distal nephron, indicating that this hormone interacts with a distal renal tubular site to influence the control of sodium excretion in man.
Cappuccio
F P
FP
Department of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy.
Strazzullo
P
P
Barba
G
G
Iacone
R
R
Buckley
M G
MG
Sugden
A L
AL
Miller
M
M
Sagnella
G A
GA
MacGregor
G A
GA
Mancini
M
M
D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D003404:Creatinine / Q000652:urine; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008094:Lithium / Q000652:urine; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology; D012016:Reference Values; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*
D016651:Lithium Carbonate; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D008094:Lithium; D012964:Sodium; D003404:Creatinine; D012083:Renin