title: Actively induced experimental allergic orchitis in Lewis-resistant (Le-R) rats: reversibility of disease resistance by immunization with Bordetella pertussis.
abstract: Differential susceptibility to the induction of experimental allergic orchitis (EAO) was examined in Lewis/NCr and Le-R subline rats. Lewis/NCr rats were found to be fully susceptible to the induction of EAO whereas Le-R subline rats were not. Disease resistance exhibited by Le-R rats could be overcome by including Bordetella pertussis in the immunization protocol. However, reversal of resistance with B. pertussis was dependent on the dose of rat testicular homogenate in the inoculum and found to be effective only at lower doses of antigen (10 mg/rat). Disease resistance in Le-R rats as well as B. pertussis-induced reversal of resistance did not appear to be associated with either (1) a significant difference in the number of mast cells in the ductus efferentes, the anatomic location of the earliest inflammatory infiltrates, or (2) an alteration in the phenotypic expression of either innate or B. pertussis-induced sensitivity to vasoactive amines. The results are discussed in the context of the role of B. pertussis in other animal models of organ-specific autoimmune diseases. It is proposed that the phenotypic expression of resistance to EAO in Le-R rats is a result of a mutation in a common regulatory locus affecting susceptibility to multiple autoimmune diseases and whose immunoregulatory action is normally exerted during the sensitization phase of the immune response.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, School of Medicine, Philadelphia 19104.
authors.forename: C
authors.initials: C
authors.lastname: Teuscher
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: W F
authors.initials: WF
authors.lastname: Hickey
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology; D007114:Immunization; D008297:Male; D008407:Mast Cells / Q000502:physiology; D009154:Mutation; D009920:Orchitis / Q000209:etiology* / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew