[Effect of liposomes on the adrenoreactivity of the papillary muscle].
Unloaded phosphatidylcholine-cholesterol liposomes enhanced the affinity of adrenoreactive system of the rat heart muscle with the ligands and altered the degree of adrenoreceptors' negative cooperativity. The radioligand analysis with 3H-dihydroalprenolol revealed that the liposomes altered kinetic properties of sarcolemma's receptors as revealed by the enhancement of affinity with the marker, decreasing of maximal specific binding and augmentation of the degree of receptors' negative cooperativity.
Kozlov
A G
AG
Los'
G V
GV
Stefanov
A V
AV
D000818:Animals; D002784:Cholesterol / Q000494:pharmacology / Q000502:physiology; D004082:Dihydroalprenolol / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008081:Liposomes / Q000494:pharmacology*; D008563:Membrane Lipids / Q000032:analysis / Q000502:physiology; D010210:Papillary Muscles / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D010713:Phosphatidylcholines / Q000494:pharmacology; D010743:Phospholipids / Q000032:analysis / Q000502:physiology; D011869:Radioligand Assay; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D012508:Sarcolemma / Q000032:analysis / Q000187:drug effects / Q000502:physiology
D008081:Liposomes; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D002784:Cholesterol
Vliianie liposom na adrenoreaktivnost' papilliarnoĭ myshtsy serdtsa.