The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs.
The c-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs.
Sagata
N
N
Tsukuba Science Center (RIKEN), Ibaraki, Japan.
Watanabe
N
N
Vande Woude
G F
GF
Ikawa
Y
Y
D000818:Animals; D001757:Blastomeres / Q000166:cytology; D002455:Cell Division; D002970:Cleavage Stage, Ovum / Q000166:cytology*; D005306:Fertilization; D006131:Growth Inhibitors; D007158:Immunologic Techniques; D008540:Meiosis; D008677:Metaphase; D009865:Oocytes / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000502:physiology*; D017231:Proto-Oncogene Proteins c-mos; D014982:Xenopus laevis
D006131:Growth Inhibitors; D011518:Proto-Oncogene Proteins; D017231:Proto-Oncogene Proteins c-mos