Postradiation astrocytoma. Report of two cases.
The authors describe two cases of malignant astrocytomas associated with previous radiation therapy in childhood for intracranial germinoma and craniopharyngioma. In both patients, there was no recurrence at the primary tumor site. Because of a geometric coincidence between the tumor location and the radiation field, radiotherapy was strongly implicated as a cause of these two astrocytomas.
Kitanaka
C
C
Department of Neurosurgery, University of Tokyo Hospital, Japan.
Shitara
N
N
Nakagomi
T
T
Nakamura
H
H
Genka
S
S
Nakagawa
K
K
Akanuma
A
A
Aoyama
H
H
Takakura
K
K
D000293:Adolescent; D001254:Astrocytoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002648:Child; D003397:Craniopharyngioma / Q000532:radiotherapy; D004407:Dysgerminoma / Q000532:radiotherapy; D005260:Female; D005909:Glioblastoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced; D010870:Pineal Gland; D010911:Pituitary Neoplasms / Q000532:radiotherapy