[Evaluation of the clinico-therapeutic response to oral gold salts in patients with rheumatoid arthritis].
The authors investigated the possible correlation between blood concentrations and clinical outcome in 38 auranofin-treated patients with rheumatoid arthritis, diagnosed according to ARA criteria. The results showed that the whole blood gold concentrations did not correlate with the clinical parameters investigated and some laboratory findings. The authors discuss this lack of correlation, suggesting that a clear genetic disposition can interfere with the clinical response, affecting the metabolism and kinetics of the drug.
Giordano
N
N
Biasi
G
G
Morozzi
G
G
Taddeo
A
A
Frati
E
E
Marcolongo
R
R
Paternò
E
E
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D001310:Auranofin / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001310:Auranofin
Valutazione della risposta clinico-terapeutica ai sali d'oro per os in pazienti affetti da artrite reumatoide.