[How should the plasma ACTH level in treated Addison's disease patients be interpreted?].
The ACTH plasma levels of 73 treated Addisonian patients have been analysed and compared to those obtained in 40 normal subjects after metyrapone-induced nocturnal cortisol deprivation (75 to 700 pg/ml). Using this new criterion, it appears that patients with ACTH plasma levels lower than 75 pg/ml are most often over-treated; those with ACTH plasma levels between 75 to 700 pg/ml are most often well substituted; and those with ACTH plasma levels higher than 700 pg/ml are under-treated. In this latter group coincidental high plasma renin activity is generally present, pointing to the possible role of the renin-angiotensin system in maintaining high ACTH plasma levels.
Pehuet-Figoni
M
M
Centre de Recherches des Maladies Endocriniennes et Métaboliques, Hôpital Cochin, Paris.
Bertagna
X
X
Girard
F
F
Bricaire
H
H
Luton
J P
JP
D000224:Addison Disease / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D008797:Metyrapone; D008875:Middle Aged
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D008797:Metyrapone
Comment interpréter l'ACTH plasmatique de l'addisonien traité?