[Evaluation of plasma protein S in pregnancy].
The total plasma protein S levels in 35 normal persons and 26 pregnant women were examined, using the immunoelectrophoresis method. The results showed a considerably lower level of total plasma protein S in the pregnant women than in the non-pregnant (94.9 +/- 18.4%/107.8 +/- 16.9%, P less than 0.05), but no significant difference existed between the normal men and women (P greater than 0.05). Moreover, a significant decrease was observed in the free plasma protein S with cofactor activity, in the pregnant women. This decline may be involved in the acceleration of the hypercoagulative state and the risk of thrombosis in the pregnant women.
Cheng
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D000328:Adult; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007122:Immunoelectrophoresis; D011247:Pregnancy / Q000097:blood*; D017293:Protein S
D006023:Glycoproteins; D017293:Protein S