An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.
An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.
Hyman
S E
SE
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
Comb
M
M
Pearlberg
J
J
Goodman
H M
HM
D001483:Base Sequence; D000242:Cyclic AMP / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000032:analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D003850:Deoxyribonuclease I; D004742:Enhancer Elements, Genetic / Q000187:drug effects*; D004745:Enkephalins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation; D010703:Phorbol Esters / Q000494:pharmacology*; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism
D004268:DNA-Binding Proteins; D004745:Enkephalins; D010703:Phorbol Esters; D011498:Protein Precursors; C029992:proenkephalin; D004247:DNA; D000242:Cyclic AMP; D003850:Deoxyribonuclease I