Unilateral induction of c-fos protein in cortex following cortical devascularization.
The proto-oncogene c-fos is rapidly induced by a variety of stimuli including wounding of the cortex. In an attempt to define the conditions necessary for c-fos activation, we have studied the effects of cerebral devascularization (CD; unilateral pial disruption), a procedure which results in ischaemia without producing direct physical damage to the tissues. Cerebral devascularization produces c-fos activation throughout the ipsilateral cortex; this effect lasts for about 4 h and is not confined to the area subjacent to pial disruption. The activation of c-fos is not prevented by even high doses of benzodiazepines but is effectively reduced by the N-methyl-D-aspartate (glutamate) receptor antagonist ketamine.
Herrera
D G
DG
Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Robertson
H A
HA
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000098:blood supply / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D007150:Immunohistochemistry; D008297:Male; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos