Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum.
Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss during aging was 19%, and also varied considerably within the different striatal regions. Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
Han
Z
Z
Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD 21224.
Kuyatt
B L
BL
Kochman
K A
KA
DeSouza
E B
EB
Roth
G S
GS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002452:Cell Count; D003342:Corpus Striatum / Q000166:cytology / Q000378:metabolism*; D003936:Diagnosis, Computer-Assisted; D008297:Male; D009474:Neurons / Q000378:metabolism; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone