Mathematical model of CD4+ lymphocyte depletion in HIV infection.
The CD4+ lymphocyte depletion in human immunodeficiency virus (HIV)-infected persons seems to be affected by HIV products. As the dynamics of the concentration of HIV products is reciprocal to that of non-replicating antigen used for induction of tolerance, the mathematical model of immunological tolerance can be used to describe the dynamics of CD4+ lymphocyte depletion. To stimulate the clinically observed dynamics, it is necessary to include the limitation of HIV growth by the corresponding cytotoxic T cells and their dependence on the helper effect of CD4+ lymphocytes. Simulation analysis suggests that qualitatively similar results are obtained if immature, mature, or both categories of CD4+ lymphocytes considered in the model are depleted by the HIV products.
Hraba
T
T
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Dolezal
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D008433:Mathematics; D008954:Models, Biological; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D013997:Time Factors
D000945:Antigens, Differentiation, T-Lymphocyte