A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2.
We extended the physical map of the mouse int-2 locus by demonstrating that the site of insertion for mouse mammary tumor virus DNA in plaque-type mammary tumors of GR mice is directly linked to int-2. An additional example of proviral integration is described in which a provirus in a presumed enhancer-insertion mode 15 kilobases upstream of the int-2 promoters is capable of activating expression of the gene at levels typical of other virally induced mammary tumors.
Peters
G
G
Imperial Cancer Research Fund Laboratories, St. Bartholomews Hospital, London, United Kingdom.
Brookes
S
S
Placzek
M
M
Schuermann
M
M
Michalides
R
R
Dickson
C
C
D000818:Animals; D002874:Chromosome Mapping; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D015183:Restriction Mapping