[Familial occurrence of leukemia. Cytogenetic considerations apropos of 2 cases].
The authors describe a case of family leukemia: an acute myeloid leukemia preceded by Pelger's anomaly in a 77 year old brother and a chronic myeloid leukemia chromosome Ph + in a 71 years old sister, sixteen years after the first one. The authors formulate a hypothesis that both haematologic diseases may have in common a mistake of transcription caused by an anomalous m RNA.
Spanò
G M
GM
Barletta
R
R
Fiorentino
E
E
De Pedrini
P
P
Meloni
F
F
Rapisarda
R
R
Transi
M G
MG
D000368:Aged; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D008297:Male; D010381:Pelger-Huet Anomaly / Q000150:complications; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D012333:RNA, Messenger
Familiarità leucemica. Considerazioni citogenetiche a proposito di due casi.