Possible increase of dopamine-beta-hydroxylase activity in the locus ceruleus of paranoid schizophrenic patients: a preliminary post-mortem study.
Five schizophrenic brains and seven control brains were compared for phenylethanolamine-N-methyl-transferase and dopamine-beta-hydroxylase activities. The two groups were comparable in age, sex, and post-mortem delay before autopsy. A radioenzymatic assay showed a statistically significant increase of dopamine-beta-hydroxylase activity in the rostral part of the locus ceruleus in the schizophrenic brains.
Gay
N
N
Department of Neurophysiology, University of Lyon, France.
Cottraux
J A
JA
Denoroy
L
L
Tommasi
M
M
Kopp
N
N
D000328:Adult; D000368:Aged; D002421:Caudate Nucleus / Q000473:pathology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D008125:Locus Coeruleus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009714:Nucleus Accumbens / Q000473:pathology; D010487:Periaqueductal Gray / Q000473:pathology; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism; D011699:Putamen / Q000473:pathology; D012563:Schizophrenia, Paranoid / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology; D009435:Synaptic Transmission
D004299:Dopamine beta-Hydroxylase; D010625:Phenylethanolamine N-Methyltransferase