title: Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins.
abstract: It is well known that certain bacterial toxins, e.g. cholera and pertussis toxins, ADP-ribosylate eukaryotic regulatory proteins. They have become invaluable tools in the study of G protein-linked receptors. Less well appreciated is the fact that certain strains of Clostridium botulinum types C and D produce an ADP-ribosyltransferase, termed C3. This enzyme is structurally and functionally distinct from botulinum neurotoxins C1 and D. Its substrate is the 21 kDa GTP-binding protein rho. Klaus Aktories and Alan Hall explain why C3 is now an important tool in analysing the regulatory function of the ras-related protein rho.
authors.forename: K
authors.initials: K
authors.lastname: Aktories
authors.forename: A
authors.initials: A
authors.lastname: Hall
mesh_terms: D036002:ADP Ribose Transferases; D000818:Animals; D001905:Botulinum Toxins / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D006801:Humans
chemical_list: D036002:ADP Ribose Transferases; D001905:Botulinum Toxins; D019204:GTP-Binding Proteins