Autosomal dominant familial angiolipomatosis clinically mimicking neurofibromatosis.
The autosomal dominant form of familial angiolipomatosis may be mistaken for peripheral neurofibromatosis (NF-1) due to the similarity of the family history and the occurrence of multiple subcutaneous masses, but histopathological examination of the tumors readily distinguishes these two diseases. We report here a case of familial angiolipomatosis, which was initially though to be neurofibromatosis, and the occurrence in this patient of a granular cell tumor similar to such tumors occasionally seen in neurofibromatosis. A review of the literature discloses intriguing parallels between familial angiolipomatosis and neurofibromatosis, suggesting that similar pathogenetic mechanisms may operate in both diseases.
Goodman
J C
JC
Department of Pathology, Baylor College of Medicine, Houston, Tex.
Baskin
D S
DS
D000328:Adult; D003937:Diagnosis, Differential; D005799:Genes, Dominant; D006391:Hemangioma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008067:Lipoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis*; D010375:Pedigree