title: Spontaneous lymphoblastoid transformation of cells obtained from human tonsils.
abstract: Spontaneous lymphoblastoid transformation of cells obtained from 25 human tonsils were investigated. Three Epstein-Barr virus (EBV) genome-positive lymphoblastoid cell lines were spontaneously established in tissue cultures in vitro from human tonsils. In addition, the frequency of spontaneous lymphoblastoid transformation was increased by the treatment of tumor promoter, 12-0-tetradecanoylphorbol-13-acetate and 18 lymphoblastoid cell lines were established. The data suggest that the human tonsil is a reservoir for EBV.
authors.affiliation: Department of Otolaryngology, School of Medicine, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takimoto
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: R
authors.initials: R
authors.lastname: Umeda
mesh_terms: D000293:Adolescent; D000328:Adult; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology*; D013755:Tetradecanoylphorbol Acetate / Q000493:pharmacokinetics
chemical_list: D013755:Tetradecanoylphorbol Acetate