Paraneoplastic rhinophyma and the Leser-Trélat sign.
A case of the Leser-Trélat sign associated with an underlying malignant haemangiopericytoma is described. In addition, the patient had profound hypoglycaemia and a rhinophyma-like nasal swelling which rapidly resolved post-operatively. The tumour appeared to be secreting a factor(s) which cross-reacted with both insulin receptors to induce hypoglycaemia and epidermal growth factor receptors inducing a profusion of eruptive seborrhoeic warts. It aslo had marked sebotrophic activity. The association of the Leser-Trélat sign with malignant haemangiopericytoma has not previously been described.
Mayou
S C
SC
Benn
J J
JJ
Sonksen
P H
PH
Black
M M
MM
D000328:Adult; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006393:Hemangiopericytoma / Q000150:complications*; D006801:Humans; D007642:Keratosis / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D012186:Retroperitoneal Neoplasms / Q000150:complications*; D012224:Rhinophyma / Q000209:etiology*; D012393:Rosacea / Q000209:etiology*
D066246:ErbB Receptors