title: Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
abstract: The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.
authors.affiliation: Biochemistry Division, National Cancer Center Research Institute, Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Esumi
authors.forename: H
authors.initials: H
authors.lastname: Ohgaki
authors.forename: E
authors.initials: E
authors.lastname: Kohzen
authors.forename: S
authors.initials: S
authors.lastname: Takayama
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
mesh_terms: D000818:Animals; D005260:Female; D007093:Imidazoles; D008223:Lymphoma / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens
chemical_list: D007093:Imidazoles; D009153:Mutagens; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine