[Effects of chronic ethanol intoxication on the evolution of experimental trypanosomiasis cruzi in mice].
The effect of chronic ethyl alcohol intoxication on the evolution of Trypanosoma cruzi infection in mice was studied by two experimental procedures: (1) mice after 60 days of infection with a myotropic strain of T. cruzi were submitted to chronic alcoholic intoxidation receiving a 7% ethanol solution as only liquid source for six months; (2) mice chronically intoxicated with ethanol during five months were infected with the same strain of T. cruzi and were followed up for 45 days drinking the 7% alcoholic solution. In comparison with the infected group, not treated with ethanol, the infected mice that received the ethanol showed: a) similar mortality in the two experiments; (b) higher parasitemia in the acute phase and more frequent blood parasites in the chronic phase; (c) myocarditis with less severe cellular exudation but with increased fibrosis; (d) in the skeletal muscle, milder myositis and low frequency of arteritis and hyaline thrombi.
Gomes N das
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Departamento de Patologia Centro Biomédico, Universidade Federal do Espírito Santo.
Pereira
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FE
D000437:Alcoholism / Q000150:complications / Q000469:parasitology*; D000818:Animals; D014355:Chagas Disease / Q000150:complications / Q000473:pathology*; D008297:Male; D051379:Mice
Efeitos da intoxicação crônica com o etanol na evolução da tripanosomíase cruzi experimental no camundongo.