title: Antigen-presenting cells for unprimed T cells.
abstract: The triggering requirements of T cells differ for primed and unprimed cells: primed T cells can be triggered to produce lymphokines without viable antigen-presenting cells (APCs), apparently by crosslinking the T-cell receptor (TCR). Unprimed T cells do, however, require viable APCs and here Jonathan Sprent and Mary Schaefer review what type of cells can carry out this function, with particular reference to APCs for unprimed CD8+ cells.
authors.forename: J
authors.initials: J
authors.lastname: Sprent
authors.forename: M
authors.initials: M
authors.lastname: Schaefer
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000145:classification / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II