title: [Clinicopathologic investigation of 63 cases of pituitary adenoma--special reference to immunohistochemical study of hormone production].
abstract: We have referred 63 cases of pituitary adenoma during past 10 years at department pathology of Hokkaido University Hospital. The mean age at diagnosis was 38 years, with a range from 13 to 73 years. 35 patients complained of non-hormonal sign (head ache, disturbance of vision, disturbance of consciousness, fatigability), 32 patients presented with hormonal sign (acromegaly, troubles of menstruation, galactorrhoea, cushing syndrome) and 7 patients had both signs. Immunohistochemically, GH cell adenoma was 16 cases, Prolactine cell adenoma was 11 cases, ACTH cell adenoma was 4 cases, Non-functioning adenoma was 19 cases and Mixed type was 10 cases.
authors.affiliation: Department of Pathology, Hokkaido University Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Nojima
authors.forename: K
authors.initials: K
authors.lastname: Takebayashi
authors.forename: N
authors.initials: N
authors.lastname: Sugimoto
authors.forename: K
authors.initials: K
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D000236:Adenoma / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000096:biosynthesis; D000328:Adult; D000368:Aged; D005260:Female; D013006:Growth Hormone / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D011388:Prolactin / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone