The renal and haemodynamic effects of a 10 h infusion of glutamyl-L-dopa in normal man.
1. gamma-L-glutamyl-L-dopa (gludopa) and placebo were given by intravenous infusion to 12 healthy salt replete men for 10 h in a single-blind randomised fashion. 2. Gludopa caused a cumulative natriuresis of 46.5 mmol compared with placebo with a biphasic pattern and this was associated with a small reduction in body weight. 3. A small fall in arterial blood pressure and rise in pulse rate was seen with gludopa. 4. Plasma renin activity, atrial natriuretic peptide and urine kallikrein excretion were unchanged by gludopa but a small fall in urine aldosterone excretion, urine flow rate and free water clearance occurred. 5. The renal effects of gludopa are modest and last for only a few hours after the start of infusion.
MacDonald
T M
TM
Department of Clinical Pharmacology, Royal Infirmary, Edinburgh.
Jeffrey
R F
RF
Lee
M R
MR
D000328:Adult; D000450:Aldosterone / Q000652:urine; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D004298:Dopamine / Q000097:blood / Q000652:urine; D004573:Electrolytes / Q000652:urine; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood
D004573:Electrolytes; D000450:Aldosterone; C017342:gamma-glutamyl DOPA; D004295:Dihydroxyphenylalanine; D009320:Atrial Natriuretic Factor; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D011188:Potassium; D004298:Dopamine