The effect of tripotassium dicitrato bismuthate on pepsin activity.
We have studied the effect of tripotassium dicitrato bismuthate on the peptic activity of gastric juice, both basal and pentagastrin-stimulated, from five healthy volunteers using porcine pepsin solution as a control. Tripotassium dicitrato bismuthate showed no inhibition of the proteolytic activity of either the pure porcine or the human pepsin in the gastric juice. The ulcer healing efficacy of tripotassium dicitrato bismuthate is unlikely to be related to a gastric anti-protease effect.
De Beaux
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AC
Intestinal Disease Research Unit, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Defize
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J
Hunt
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RH
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005750:Gastric Juice / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D009942:Organometallic Compounds / Q000494:pharmacology*; D010434:Pepsin A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011480:Protease Inhibitors; D013552:Swine
D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D011480:Protease Inhibitors; D010434:Pepsin A; C002791:bismuth tripotassium dicitrate