title: Primary small cell carcinoma of the esophagus.
abstract: A primary small cell carcinoma of the esophagus in a 61-year-old woman was treated by transhiatal esophagectomy. The clinical data were correlated with data obtained from a review of the 129 cases reported in the world literature, thereby providing a clinical profile and suggested management strategy for this rare type of esophageal malignancy. Presenting symptoms of esophageal small cell carcinoma include dysphagia (75.3%), weight loss (38.4%), and chest pain (23.3%). Treatment regimens have included surgical intervention in 58%, radiotherapy in 10%, chemotherapy in 6%, or some combination of these in 26%. Overall survival is only 20.7 weeks after diagnosis. The fact that three fourths of affected patients had metastatic disease at the time of diagnosis leads us to recommend surgical intervention plus systemic chemotherapy in these patients.
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Ohio 45267.
authors.forename: D W
authors.initials: DW
authors.lastname: McFadden
authors.forename: M
authors.initials: M
authors.lastname: Rudnicki
authors.forename: M A
authors.initials: MA
authors.lastname: Talamini
mesh_terms: D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D004947:Esophagus / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis