Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon.
The object of the present study was to determine the maternal plasma pharmacokinetics of doxylamine (the antihistamine component of Bendectin) following Bendectin administration. Bendectin was administered daily, po, at a dosage approximately 10 times the maximum human therapeutic dosage (7 mg/kg/day) throughout organogenesis (approximately days 22 through 50 of gestation) to three cynomolgus monkeys, four rhesus monkeys, and five baboons. Two pharmacokinetic experiments were performed in each animal, one on the first day of treatment and one on the last day of treatment. Although this study was not designed specifically as a teratologic examination, no morphologic abnormalities were observed when the fetuses were examined on approximately day 100 of gestation. A single-compartment, parallel first- and second-order elimination model was used to analyze the data. Although considerable interindividual variation was evident, no significant differences between species were observed when the half-life for the absorption of doxylamine from the gut or the elimination of doxylamine and metabolites from the plasma were compared. The plasma elimination half-lives and the clearance values were not altered by the 29 days of Bendectin treatment for any of the species. Only the half-life for the absorption of doxylamine in the baboon was reduced by daily dosing with Bendectin, but this did not alter doxylamine elimination. Thus, the pharmacokinetics of doxylamine administered as Bendectin were similar in the three nonhuman primate species examined and were not altered by repeated daily administration.
Rowland
J M
JM
California Primate Research Center, University of California, Davis.
Slikker
W
W
Holder
C L
CL
Denton
R
R
Prahalada
S
S
Young
J F
JF
Hendrickx
A G
AG
D000818:Animals; D002849:Chromatography, Gas; D004025:Dicyclomine; D004319:Doxylamine / Q000493:pharmacokinetics* / Q000633:toxicity; D004338:Drug Combinations; D005260:Female; D006207:Half-Life; D008252:Macaca fascicularis; D008253:Macaca mulatta; D010215:Papio; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects / Q000378:metabolism*; D011736:Pyridoxine / Q000493:pharmacokinetics* / Q000633:toxicity
D004338:Drug Combinations; C004454:dicyclomine, doxylamine, pyridoxine drug combination; D004025:Dicyclomine; D004319:Doxylamine; D011736:Pyridoxine