elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.
The myb-ets-containing acute leukemia virus, E26, transforms myeloblasts and erythroblasts in culture and causes a mixed erythroid and myeloid leukemia in chicks. Genes (ets-1, ets-2, and erg) with variable relatedness to the v-ets oncogene of the E26 virus have been identified, cloned, and characterized in several species. Two new members (elk-1 and elk-2) of the ets oncogene superfamily have now been identified. Nucleotide sequence analysis of the elk-1 cDNA clone revealed that this gene encodes a 428-residue protein whose predicted amino acid sequence showed 82% similarity to the 3' region of v-ets. The elk or related sequences appear to be transcriptionally active in testis and lung. The elk cDNA probe detects two loci in the human genome, elk-1 and elk-2, which map to chromosome regions Xp11.2 and 14q32.3, respectively. These loci are near the translocation breakpoint seen in the t(X;18) (p11.2;q11.2), which is characteristic of synovial sarcoma, and the chromosome 14q32 breakpoints seen in ataxia telangiectasia and other T cell malignancies. This suggests the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors.
Rao
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VN
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Huebner
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K
Isobe
M
M
ar-Rushdi
A
A
Croce
C M
CM
Reddy
E S
ES
D000595:Amino Acid Sequence; D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D002642:Chick Embryo; D002645:Chickens; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D015342:DNA Probes; D004268:DNA-Binding Proteins; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009857:Oncogenes; D011518:Proto-Oncogene Proteins; D051381:Rats; D012191:Retroviridae Proteins / Q000235:genetics* / Q000302:isolation & purification; D014157:Transcription Factors; D014178:Translocation, Genetic; D014960:X Chromosome; D050807:ets-Domain Protein Elk-1
D015342:DNA Probes; D004268:DNA-Binding Proteins; C494112:ELK1 protein, human; C494113:Elk1 protein, mouse; C494114:Elk1 protein, rat; D011518:Proto-Oncogene Proteins; D012191:Retroviridae Proteins; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1