A double-blind trial of treatment of seborrhoeic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream.
Fifty patients with seborrhoeic dermatitis were treated with 2% ketoconazole cream (n = 24) or with 1% hydrocortisone cream (n = 26) for 4 weeks in a double-blind comparative study. These twice daily applications resulted in 87.2% symptomatic improvement for hydrocortisone vs. 81.6% for ketoconazole. The number of P. ovale yeasts was significantly reduced after the application of ketoconazole compared with hydrocortisone. The incidence of side-effects was low in both groups.
Katsambas
A
A
A. Sygros Hospital for Diseases of the Skin, University of Athens, Greece.
Antoniou
C
C
Frangouli
E
E
Avgerinou
G
G
Michailidis
D
D
Stratigos
J
J
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008290:Malassezia; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000382:microbiology
D000893:Anti-Inflammatory Agents; D007654:Ketoconazole; D006854:Hydrocortisone