Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines.
We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.
Masucci
M G
MG
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Stam
N J
NJ
Torsteinsdottir
S
S
Neefjes
J J
JJ
Klein
G
G
Ploegh
H L
HL
D000483:Alleles; D002051:Burkitt Lymphoma / Q000276:immunology*; D005805:Genes, MHC Class I; D004854:Herpesvirus 4, Human; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D014407:Tumor Cells, Cultured
D015395:Histocompatibility Antigens Class I