[Modification by cystamine of radiation-induced free radical damage to biomolecules in tissues of mouse organs].
The method of low-temperature ESR-spectroscopy was used to study a modifying effect of cystamine on the yield of radiation-induced free radicals in different biomolecules of liver and spleen tissues of mice. Intraperitoneal administration of cystamine (150 mg/kg) 15 min before isolation and freezing of the tissues was shown to reduce by 11 per cent the yield of radicals of H-adducts of thymine DNA bases, to decrease by 23 per cent the yield of radicals of triacyglycerol and phospholipid radiolysis, and to increase by 24 per cent the yield of radicals of lipid fatty acid residues in splenic tissue. According to the criterion used, cystamine has no modifying action on the yield of free-radical damages to liver biomolecules.
Svistunenko
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DA
Gudtsova
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KV
D000818:Animals; D003538:Cystamine / Q000627:therapeutic use*; D004578:Electron Spin Resonance Spectroscopy; D005227:Fatty Acids / Q000528:radiation effects; D005609:Free Radicals; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D010743:Phospholipids / Q000528:radiation effects; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects*; D013941:Thymine / Q000528:radiation effects; D014280:Triglycerides / Q000528:radiation effects
D005227:Fatty Acids; D005609:Free Radicals; D010743:Phospholipids; D014280:Triglycerides; D013941:Thymine; D003538:Cystamine
Modifikatsiia tsistaminom radiatsionnykh svobodnoradikal'nykh povrezhdeniĭ biomolekul v tkaniiakh organov mysheĭ.