title: Effect of prostaglandin E in multiple experimental models. VI. Effect on T-cell subsets.
abstract: Burn injuries have been shown to impair immune function. One of the hypotheses for the etiology of the immunosuppression is that burn injuries result in an elevation of prostaglandin E (PGE) levels which then impair leukocyte function. We evaluated the effect of PGE levels on immune function in multiple animal models utilizing T cell subset levels for our immunologic measurements. Elevations in PGE levels were achieved by administering 16,16-dimethyl-prostaglandin E (dPGE) and reductions by administering indomethacin. The animal models included burned rats, burned-septic rats, and nonburned rats. Neither indomethacin nor dPGE administration resulted in alterations of any of the T cell subset populations in our models.
authors.affiliation: US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234-5012.
authors.forename: J P
authors.initials: JP
authors.lastname: Waymack
authors.forename: R F
authors.initials: RF
authors.lastname: Guzman
authors.forename: D G
authors.initials: DG
authors.lastname: Burleson
authors.forename: A T
authors.initials: AT
authors.lastname: McManus
authors.forename: A D
authors.initials: AD
authors.lastname: Mason
authors.forename: B A
authors.initials: BA
authors.lastname: Pruitt
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000818:Animals; D002056:Burns / Q000150:complications / Q000276:immunology*; D004195:Disease Models, Animal; D007213:Indomethacin / Q000494:pharmacology; D007958:Leukocyte Count; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000150:complications / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014946:Wound Infection / Q000150:complications / Q000276:immunology*
chemical_list: D011459:Prostaglandins E, Synthetic; D015064:16,16-Dimethylprostaglandin E2; D007213:Indomethacin