Regional changes in ornithine decarboxylase activity and polyamine levels during thyroxine-induced cardiac hypertrophy.
Ornithine decarboxylase activities (ODC) and polyamine levels were determined in five cardiac regions of the rat heart, following daily administration of 1 mg/kg of thyroxine, in the right and left atria, the right and left ventricles and the septum. The thyroxine stimulated ODC activity in all five regions of the heart. Enzyme activity in the left atrium and the septum peaked a day earlier than in other regions and the decline of ODC activity was slower. Putrescine in control animals was present in all regions except the right atrium, where its content was below detectable levels. Following the administration of thyroxine, the putrescine content of the left atrium, the right ventricle and the septum declined, while spermidine and spermine levels remained unchanged. In direct contrast to the other regions of the heart, thyroxine stimulated an increase in polyamines, as well as in weight which occurred exclusively in the left ventricle. These findings suggest a causal relationship between increased polyamines and hypertrophy.
Tipnis
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Department of Pharmacology, University of Texas Medical School, Houston 77225.
Skiera
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D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000201:enzymology*; D006325:Heart Atria / Q000032:analysis / Q000201:enzymology; D006346:Heart Septum / Q000032:analysis / Q000201:enzymology; D006352:Heart Ventricles / Q000032:analysis / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000201:enzymology*; D009929:Organ Size; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine; D013997:Time Factors
D011073:Polyamines; D009955:Ornithine Decarboxylase; D013974:Thyroxine