title: [Correction of selenium deficiency in patients with renal failure undergoing hemodialysis].
abstract: Plasma selenium levels (p Se) as well as glutathione peroxidase activity in plasma (p GPx) and in erythrocytes (e GPx) were measured in 39 haemodialysis patients. Glutathione peroxidase is a selenium-dependent enzyme which protects cells against oxidation. The mean level values obtained were significantly lower in patients than in controls: p Se: 38 +/- 14 versus 88 +/- 17 micrograms/l; p GPx: 15 +/- 32 versus 334 +/- 41 IU/l; e GPx: 19 +/- 4 versus 26 +/- 4 IU/g Hb. These values were found to correlate significantly with the duration of dialysis and with the type of membrane utilized. The total muscular mass was significantly smaller in patients with the lowest p Se or p GPx values. At echocardiography, septal hypertrophy correlated with both p Se and p GPx. Twenty patients were supplemented with sodium selenite administered orally at the end of each haemodialysis session during 6 months. After this period, muscular mass and septal hypertrophy were decreased and the echocardiographic contractility parameters were improved, albeit not significantly.
authors.affiliation: Service Néphrologie-Dialyse, Hôpital national de Saint-Maurice, Paris.
authors.forename: M D
authors.initials: MD
authors.lastname: Saint-Georges
authors.forename: D J
authors.initials: DJ
authors.lastname: Bonnefont
authors.forename: B A
authors.initials: BA
authors.lastname: Bourely
authors.forename: M C
authors.initials: MC
authors.lastname: Jaudon
authors.forename: P
authors.initials: P
authors.lastname: Cereze
authors.forename: C
authors.initials: C
authors.lastname: Gard
authors.forename: J C
authors.initials: JC
authors.lastname: Chaumeil
authors.forename: C L
authors.initials: CL
authors.lastname: d'Auzac
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology; D004452:Echocardiography; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012643:Selenium / Q000097:blood / Q000172:deficiency*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium
vernacular_title: Correction du déficit en sélénium chez des insuffisants rénaux hémodialysés.