Production of wet-dog shakes in rats and down-regulation of spinal 5-HT2 receptors.
5-HT2 receptors, labelled with [3H]ketanserin, were shown to occur in a low concentration in the spinal cord of rats. The receptor numbers were reduced by 37% within 3 h of giving paroxetine to phenelzine-treated rats and remained low for at least 24 h. Paroxetine also evoked wet-dog shakes. These were of similar frequency in spinal (Cl transection) and intact rats and lessened within 3 h, perhaps because of receptor down-regulation.
Koshikawa
N
N
Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan.
Maruyama
Y
Y
Stephenson
J D
JD
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D017374:Paroxetine; D010624:Phenelzine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017374:Paroxetine; D007650:Ketanserin; D010624:Phenelzine