NGF receptor immunoreactivity in aged rat brain.
The cellular distribution of nerve growth factor (NGF) receptor (NGFR) immunoreactivity in 3 cholinergic nuclei (medial septal nucleus, nucleus of the diagonal band and nucleus basalis magnocellularis) of the aged rat brain was compared to that of young-adult animals. In young-adult rats, NGFR immunoreactivity was strong in the neuronal body and in the whole dendritic tree. In aged animals, NGFR immunoreactivity was weak in both cell body and dendrites and was practically absent in the dendrite's distal portion. The loss of dendritic NGFR may play a critical role in the decline of neuronal function in the aging brain.
Gómez-Pinilla
F
F
Department of Psychobiology, University of California, Irvine 92717.
Cotman
C W
CW
Nieto-Sampedro
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism*; D005625:Frontal Lobe / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology; D017475:Receptors, Nerve Growth Factor; D012686:Septal Nuclei / Q000254:growth & development / Q000378:metabolism*; D013377:Substantia Innominata / Q000254:growth & development / Q000378:metabolism*
D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor