Superoxide, iron, vascular endothelium and reperfusion injury.
It is proposed that vascular endothelium has an intrinsic capacity to generate O2- for regulatory purposes such as inactivation of endothelium-derived relaxing factor. Ischaemia can disrupt the functioning of this oxidant-generating system, resulting in greater O2- generation when O2 is restored. Ischaemia-induced cellular injury can also lead to release of iron ions, that, upon reperfusion, cause conversion of O2- and H2O2 to powerfully-oxidizing species (such as .OH) that further injure the endothelium.
Halliwell
B
B
Department of Biochemistry, King's College, University of London, UK.
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000502:physiology*; D015427:Reperfusion Injury; D013482:Superoxide Dismutase / Q000502:physiology; D013481:Superoxides / Q000502:physiology*
D013481:Superoxides; D007501:Iron; D013482:Superoxide Dismutase