5HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibits non-opioid analgesia in defeated mice: influence of route of administration.
Recent studies have suggested that anxiety may be an important factor in the non-opioid analgesic response to defeat in muroid rodents. In the present study, we have examined the influence of the 5-HT1A receptor agonist, 8-OH-DPAT, on basal nociception and defeat analgesia in male DBA/2 mice. Our results show that, while devoid of intrinsic activity on the mouse tail-flick assay, 8-OH-DPAT blocks the analgetic consequences of defeat. A ten-fold potency differential was observed as a function of route of injection, with minimum effective doses of 0.1 and 1.0 mg/kg for subcutaneous and intraperitoneal administration, respectively. Although further studies are required, these preliminary data support 5-HT1A receptor involvement in the mediation of this form of adaptive pain inhibition.
Rodgers
R J
RJ
Pharmacoethology Laboratory, School of Psychology, University of Bradford, UK.
Shepherd
J K
JK
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000698:Analgesia; D000818:Animals; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009281:Naphthalenes / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012919:Social Behavior; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000494:pharmacology*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin