title: The molecular weight of the endothelial cell IL-1 receptor is 78,000.
abstract: Human endothelial cells have been shown to be distinctive from other IL-1 responsive cells (e.g. murine thymocytes), in the equal units of murine and human IL-1 do not have the same endothelial cell stimulatory effect, as measured by increased lymphocyte adherence. In this paper, the cell surface IL-1 receptors of human endothelial cells, fibroblasts and T-lymphocytes have been compared, to investigate whether endothelial cells have a unique receptor for IL-1. IL-1 receptors were isolated by both immunoprecipitation and chemical cross-linking to the ligand. Both techniques demonstrated that human endothelial cells are similar to human T-lymphocytes and fibroblasts, in that they all have a 78,000 mol. wt IL-1 receptor.
authors.affiliation: Epitope Inc., Beaverton, OR 97006.
authors.forename: T R
authors.initials: TR
authors.lastname: Thieme
authors.forename: C R
authors.initials: CR
authors.lastname: Wagner
mesh_terms: D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D004727:Endothelium / Q000166:cytology; D006801:Humans; D007375:Interleukin-1; D008970:Molecular Weight; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1
chemical_list: D007375:Interleukin-1; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1