[A study on evaluation of circulating anticoagulant in borderline cases].
Detection of circulating anticoagulant (CA) is clinically important in patients with SLE, habitual abortion and other hemorrhagic and thrombotic disorders. We have studied CA in 83 patients with such disorders. Thirty-one of 83 (37%) had positive CA and 16 of 83 (19%) had negative CA, while 36 of 83 (44%) showed borderline pattern of CA. The experiment was undertaken to detect CA clearly in patients with borderline CA, by using diluted APTT or PT reagents. When we used 5% diluted reagent in APTT or 50% diluted reagent in PT, constant value of clotting time showed 1.8% or 1.2%, respectively. Seven of 10 with borderline CA cases tested here revealed positive CA by using diluted reagents. Furthermore 2 of remaining 3 with borderline CA cases showed positive anti-cardiolipin antibodies, suggesting of presence of lupus anticoagulants. These results suggest that CA in borderline cases should be considered to be positive and to be possibly derived from lupus anticoagulants.
Ishii
K
K
Himizu
M
M
Ono
F
F
Yamamoto
M
M
Kawai
Y
Y
Watanabe
K
K
Iri
H
H
D001323:Autoantibodies / Q000032:analysis; D001778:Blood Coagulation Disorders / Q000097:blood / Q000276:immunology; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology; D005069:Evaluation Studies as Topic; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D007136:Immunoglobulins; D016682:Lupus Coagulation Inhibitor; C019158:circulating anticoagulants