Assessment of superoxide-mediated release of vascular-inhibitory factor(s) from endothelial cells by using a two-bath system.
Release of a vascular-inhibitory factor from endothelial cells (EC), different from endothelium-derived relaxant factor (EDRF), was identified through use of a two-bath system. This two-bath system precluded the effects of oxygen-free radicals that appear when electrical field stimulation (EFS) is directly imposed on detector muscle.
Hong
K W
KW
Department of Pharmacology, College of Medicine, Pusan National University, Korea.
Lee
W S
WS
Rhim
B Y
BY
Shin
Y W
YW
D000818:Animals; D001013:Aorta, Thoracic; D002374:Catalase / Q000494:pharmacology; D002415:Cats; D002417:Cattle; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004558:Electric Stimulation; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*; D014665:Vasodilator Agents / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000494:pharmacology
D005609:Free Radicals; D007042:Hypoxanthines; D014665:Vasodilator Agents; D013481:Superoxides; D019271:Hypoxanthine; D012701:Serotonin; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D004121:Dimethyl Sulfoxide