Malignant islet cell tumor with rhabdomyosarcomatous differentiation.
We present a widely metastatic islet cell tumor of the pancreas with focal areas resembling rhabdomyosarcoma. To our knowledge, this is the first reported case of islet cell/carcinoid tumor exhibiting such differentiation. Desmin was localized to the rhabdoid areas by immunohistochemistry. Cross striations were not seen by light microscopy, but Z-lines and thick filaments were seen on electron microscopy.
Ferreiro
J
J
Department of Pathology, UCLA Medical Center 90024.
Lewin
K
K
Herron
R M
RM
Bhuta
S
S
D007516:Adenoma, Islet Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000473:pathology*