Photofrin II localization in rat cecum.
Laser excitation of photodynamic agents localizing in colonic tumors may allow the early diagnosis and treatment of colon cancer. The efficacy of these agents requires a high ratio of tumor to background photosensitizer accumulation and fluorescence. To assess normal colonic background fluorescence and hematoporphyrin accumulation 31 rats were studied after an intravenous injection of Photofrin II (PF-II) at a dose of 5 mg/kg. An increase in mucosal fluorescence and porphyrin content was noted in the cecum 24 hours after injection. Cecal accumulation of PF-II may affect its efficacy in the localization and treatment of cecal tumors. Further investigation into the mechanism and clinical significance of this finding is needed.
Bjorkman
D J
DJ
Division of Gastroenterology, Utah Laser Institute, University of Utah School of Medicine, Salt Lake City 84132.
Brigham
E J
EJ
Peterson
B J
BJ
Straight
R C
RC
D000818:Animals; D002432:Cecum / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D017323:Dihematoporphyrin Ether; D005260:Female; D006415:Hematoporphyrins / Q000493:pharmacokinetics*; D007834:Lasers; D010778:Photochemotherapy; D051381:Rats; D011919:Rats, Inbred Strains
D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether