Synergistic antifungal action of 8-quinolinol and its bischelate with copper(II) and with mixed ligand chelates composed of copper(II), 8-quinolinol, and aromatic hydroxy acids.
Antifungal studies were made of mixtures of minimal inhibitory concentrations (MICs) of 8-quinolinol and its bischelates with copper(II), zinc(II), and manganese(II) and with mixed ligand chelates composed of 8-quinolinol, copper(II) and a second ligand including salicylic acid, 3-hydroxy-2-naphthoic acid, 3,5-diiodosalicylic acid, and 4-bromo-3-hydroxy-2-naphthoic acid. Mixtures of the MICs of the bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II), as well as 7-iodo-8-quinolinol and its bischelate with copper(II), and 8-quinolinol and 5-iodo-8-quinolinol were also studied against six fungi: Aspergillus niger, Aspergillus oryzae, Trichoderma viride, Myrothecium verrucaria, Mucor cirinelloides, and Trichophyton mentagrophytes. With the exceptions of the mixtures of 8-quinolinol and (8-quinolinolato)(3,5-diiodosalicylato)copper(II) and (8-quinolinolato)(4-bromo-3-hydroxy-2-naphthoato)copper(II) against M. cirinelloides, all of the test organisms were inhibited by 40% or less of each mixture containing 8-quinolinol. Bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II) inhibited five fungi at 50% of the mixtures of the MICs. Mucor cirinelloides was not inhibited by bis(8-quinolinolato)copper(II), bis(8-quinolinolato)zinc(II), or by bis(7-iodo-8-quinolinolato)copper(II).(ABSTRACT TRUNCATED AT 250 WORDS)
Gershon
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Fordham University, Department of Chemistry, Bronx, NY 10458.
Clarke
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DD
Gershon
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D000935:Antifungal Agents; D002614:Chelating Agents / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006880:Hydroxy Acids / Q000494:pharmacology*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008024:Ligands; D008345:Manganese / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
D000935:Antifungal Agents; D002614:Chelating Agents; D006880:Hydroxy Acids; D006912:Hydroxyquinolines; D008024:Ligands; C063030:5-iodo-8-quinolinol; D008345:Manganese; D015125:Oxyquinoline; D003300:Copper; D015032:Zinc