title: Intravenous flunitrazepam for status epilepticus.
abstract: Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus. Case 1 was a patient with a tonic-clonic status epilepticus. Intravenous phenytoin had no effect. Case 2 had minor status epilepticus. With the intravenous administration of FZP, diluted 1:10 with distilled water at a dose of 0.03 mg/kg at a slow rate, both patients were relieved of the status epilepticus. Unlike diazepam, FZP neither looks cloudy when diluted with distilled water nor causes angialgia. No disturbances in circulation or respiration occurred. Considering that FZP has a strong anticonvulsant action on status epilepticus, it can be expected to be a useful therapeutic agent for status epilepticus in infants and children.
authors.forename: K
authors.initials: K
authors.lastname: Sumi
authors.forename: T
authors.initials: T
authors.lastname: Nagaura
authors.forename: N
authors.initials: N
authors.lastname: Sakata
authors.forename: T
authors.initials: T
authors.lastname: Nishigaki
authors.forename: M
authors.initials: M
authors.lastname: Akagi
mesh_terms: D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005445:Flunitrazepam / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D013226:Status Epilepticus / Q000188:drug therapy*
chemical_list: D005445:Flunitrazepam