Molecular cloning of an oncogenic replication-competent virus that causes lymphoproliferative disease in turkeys.
The lymphoproliferative disease virus of turkeys was molecularly cloned, structurally mapped, and shown to represent a distinct class of retroviruses evolutionarily related to the avian leukemia-sarcoma virus group. The cloned provirus did not contain any known oncogene or other cellularly derived sequences and was established as a replication-competent oncogenic entity capable of inducing the disease in the absence of any associated transforming counterpart.
Gak
E
E
Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Israel.
Yaniv
A
A
Chajut
A
A
Ianconescu
M
M
Tronick
S R
SR
Gazit
A
A
D000818:Animals; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics; D009693:Nucleic Acid Hybridization; D011201:Poultry Diseases / Q000382:microbiology*; D011533:Proviruses / Q000235:genetics* / Q000502:physiology; D015183:Restriction Mapping; D012190:Retroviridae / Q000235:genetics* / Q000502:physiology; D012192:Retroviridae Infections / Q000382:microbiology / Q000662:veterinary*; D013950:Thymus Gland / Q000382:microbiology; D014422:Turkeys; D014779:Virus Replication
D004279:DNA, Viral