[Value of sustonit in the treatment of patients with stable angina pectoris].
The clinical trial was carried out in 40 men with stable angina receiving for three weeks Sustonit mite or forte. Before and after three weeks of the treatment the exercise test was done on cycle ergometer, followed by echocardiography (for evaluation of left ventricular function) noting also the number of anginal pains and the number of nitroglycerin tablets taken as emergency treatment. In the light of the obtained results it was estimated that Sustonit reduced anginal pains in 82.5% of the patients with stable angina, and exerted a beneficial effect on the left ventricular function as evidenced by increased mean velocity of shortening of the circumferential fibres and reduced number of echocardiograms with segmental contractility disturbances in the ventricular septum and posterior wall of the left ventricle after 3 weeks of treatment. Moreover, Sustoinit treatment increased significantly the amount of work done until reaching of submaximal heart rate and working time during submaximal exercise, as well as the greatest workload necessary for reaching of submaximal heart rate. The drug had no significant effect on the heart and arterial blood pressure. Sustonit mite and forte is regarded as highly valuable and effective drug in the treatment of patients with stable angina.
Markiewicz
M
M
Rymar
B
B
Wysokiński
A
A
Trojnar
R
R
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011044:Poland
D003692:Delayed-Action Preparations; D005996:Nitroglycerin
Wartości preparatu sustonit w leczeniu chorych z dusznica bolesna stabilna.