Effect of cyproterone acetate in comparison to flutamide on the ventral prostate of adult male castrated Copenhagen-Fisher rats and on Dunning R-3327 H tumors.
In this investigation the effect of CPA was tested in comparison to FL after the procedure of double blinding on the ventral prostate of 70 adult male castrated Copenhagen-Fisher rats and on the Dunning R-3327 H tumor. Total androgen blockade by castration plus CPA or by castration plus FL induced significant decrease in prostate weight compared to the androgen deprivation by castration alone. No significant difference between CPA and FL was observed. Furthermore it was impossible to exaggerate this effect with higher doses of CPA of FL. The Dunning R-3327 H tumor did not become palpable 60 days after inoculation of the tumor cells indicating that androgen deprivation by total androgen blockade by castration plus CPA or plus FL did not exhibit any proliferative activity on the hormone-sensitive Dunning R-3327 H tumor cells.
Donn
F
F
Urologische Abteilung, Marienkrankenhaus Hamburg.
Becker
H
H
Klosterhalfen
H
H
Klein
H
H
D000726:Androgen Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000728:Androgens; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D003534:Cyproterone / Q000494:pharmacology; D017373:Cyproterone Acetate; D004311:Double-Blind Method; D005485:Flutamide / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000726:Androgen Antagonists; D000728:Androgens; D000813:Anilides; D017373:Cyproterone Acetate; D005485:Flutamide; D003534:Cyproterone