title: [The biological activity of chalone-like proteoglycans isolated from the spleen and thymus at various periods of ontogeny].
abstract: Chalone-like proteoglycans from sheep and bovine thymus and spleen were shown to suppress cell proliferation in murine thymus or spleen. Their effect appeared to be organ-specific but not species-specific. Administration of the proteoglycans resulted in a decrease in the mitotic activity of thymus and spleen cells 24h (strain C57BL), three days (hybrids), four days (nude mice) or five days (highly cancerous strain C3H/He and white mongrel mice) after birth. These changes are probably due to genetic peculiarities of immune system formation in different mouse strains. The activity of chalone-like proteoglycans from spleen and thymus of 1-, 3- and 6-months old sheep was lower than that of adult sheep (two and five years old) indicating that the proteoglycan activity increases during ontogenesis.
authors.forename: G M
authors.initials: GM
authors.lastname: Ronichevskaia
authors.forename: P N
authors.initials: PN
authors.lastname: Smirnov
authors.forename: N B
authors.initials: NB
authors.lastname: Goncharova
authors.forename: G A
authors.initials: GA
authors.lastname: Zlobina
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents; D002417:Cattle; D005838:Genotype; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects; D011509:Proteoglycans / Q000302:isolation & purification / Q000494:pharmacology*; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011509:Proteoglycans
vernacular_title: Biologicheskaia aktivnost' keĭlonopodobnykh proteoglikanov, vydelennykh iz selezenki i timusa v raznye periody ontogeneza.