title: Both recombinant interleukin-1 (beta) and purified human monocyte interleukin-1 prime human neutrophils for increased oxidative activity and promote neutrophil spreading.
abstract: Both purified human monocyte interleukin-1 and recombinant interleukin-1 (beta) primed neutrophils for increased superoxide production and chemiluminescence in response to f-met-leu-phe. In addition, purified human monocyte interleukin-1 and recombinant interleukin-1 (beta) altered neutrophil shape. Recombinant interleukin-1 (alpha) used at the same concentration of interleukin-1 (beta) did not prime neutrophils for increased superoxide production after stimulation with f-met-leu-phe. Interleukin-1 expressed by monocytes in response to endotoxin stimulation could act as a modulator of neutrophil function.
authors.affiliation: Department of Internal Medicine, University of Virginia Medical Center, Charlottesville 22908.
authors.forename: G W
authors.initials: GW
authors.lastname: Sullivan
authors.forename: H T
authors.initials: HT
authors.lastname: Carper
authors.forename: J A
authors.initials: JA
authors.lastname: Sullivan
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: G L
authors.initials: GL
authors.lastname: Mandell
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology; D007378:Interleukins / Q000494:pharmacology*; D008163:Luminescent Measurements; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D013481:Superoxides / Q000096:biosynthesis*
chemical_list: D007375:Interleukin-1; D007378:Interleukins; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine