title: Atrial myoendocrine cells (cardiodilatin/atrial natriuretic polypeptide-containing myocardiocytes) are target cells for estradiol.
abstract: Atrial myoendocrine cells of rat were investigated regarding estradiol uptake. It was found that, in addition to their specific endocrine function of producing cardiac polypeptides of the cardiodilatin/atrial natriuretic peptide (CDD/ANP) family, these cells also specifically accumulate radiolabeled estradiol. This co-localization supports the view that steroid hormones play an important role in the regulation of the CDD/ANP gene.
authors.affiliation: Institut für Anatomie und Zellbiologie, Universität Heidelberg, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Back
authors.forename: W G
authors.initials: WG
authors.lastname: Forssmann
authors.forename: W E
authors.initials: WE
authors.lastname: Stumpf
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001345:Autoradiography; D004958:Estradiol / Q000493:pharmacokinetics*; D005260:Female; D006325:Heart Atria / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D009124:Muscle Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009124:Muscle Proteins; D004958:Estradiol; D009320:Atrial Natriuretic Factor; C040651:cardiodilatin