Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease.
T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced defect in suppressor cell function was observed in the patient group but not in matched controls irrespective of whether B cells or monocytes were used as the stimulus. This defect was observed for IgG, A and M. This defect was seen both in patients with active disease and with inactive CD suggesting the possibility that a primary regulatory defect might exist in this disease. The patient group displayed normal helper cell function.
Kelleher
D
D
Department of Clinical Medicine, Trinity College Dublin, Medical School, St James' Hospital, Dublin.
Murphy
A
A
Whelan
C A
CA
Feighery
C
C
Weir
D G
DG
Keeling
P W
PW
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D007959:Lymphocyte Culture Test, Mixed; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007132:Immunoglobulin Isotypes