title: Seizures during opioid anesthetic induction--are they opioid-induced rigidity?
abstract: The tape recorded EEGs of 127 patients anesthetized with large doses of opioids were retrospectively analyzed for evidence of opioid-induced seizures, and in particular, correlated with movements that occurred during induction and could be clinically interpreted as seizures. Bilateral EEG leads in patients receiving fentanyl (20), sufentanil (20), or alfentanil (87) were recorded. Forty-six of these patients from all opioid groups manifested intense rigidity, as assessed both clinically and by EMGs recorded from eight muscles in 69 of the patients receiving alfentanil. This intense rigidity often resembled seizures, in that the phenomenon entailed severe stiffness of both limbs and trunk, with an explosive onset of myoclonic limb movements, and associated vertical nystagmus. Electroencephalographic observations were extensive, entailing 69 h of paper recordings played back from the tapes, at paper speeds of 30 or 60 mm/s, with detailed annotations from the voice track. These paper recordings were examined in detail independently by three of the investigators, who were unaware of the clinical phenomena that had occurred. The only observed EEG activity that could have been interpreted as epileptiform consisted of small sharp waves related to muscle activity or other artifact. The EEG never indicated seizure activity during these drug-induced movements and rigidity. Reports of opioid-induced seizures are reviewed and a set of criteria is offered to help achieve future consistency and credibility in evaluating this phenomenon. The available evidence does not support the existence of opioid-induced seizures in the clinical setting.
authors.affiliation: Department of Anesthesiology, University of California, San Diego.
authors.forename: N T
authors.initials: NT
authors.lastname: Smith
authors.forename: J L
authors.initials: JL
authors.lastname: Benthuysen
authors.forename: R G
authors.initials: RG
authors.lastname: Bickford
authors.forename: T J
authors.initials: TJ
authors.lastname: Sanford
authors.forename: T
authors.initials: T
authors.lastname: Blasco
authors.forename: P C
authors.initials: PC
authors.lastname: Duke
authors.forename: N
authors.initials: N
authors.lastname: Head
authors.forename: H
authors.initials: H
authors.lastname: Dec-Silver
mesh_terms: D015760:Alfentanil / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D004569:Electroencephalography; D004576:Electromyography; D005283:Fentanyl / Q000009:adverse effects* / Q000031:analogs & derivatives; D006801:Humans; D009127:Muscle Rigidity / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*; D017409:Sufentanil
chemical_list: D000777:Anesthetics; D015760:Alfentanil; D017409:Sufentanil; D005283:Fentanyl