Efficacy of a standard United Kingdom oral rehydration solution (ORS) and a hypotonic ORS assessed by human intestinal perfusion.
Human triple-lumen intestinal perfusion was used to compare water and solute absorption from the oral rehydration solution (ORS) most widely used in the United Kingdom and a new experimental hypotonic ORS (HYPO-ORS). HYPO-ORS (osmolality 210 mOsm/kg) promoted significantly greater water absorption than UK-ORS (7.03 +/- 1.1 vs 2.73 +/- 1.0 ml cm-1 h-1; P less than 0.01). HYPO-ORS produced net sodium and chloride absorption whereas the low sodium UK-ORS produced a net secretion of these ions. Bicarbonate absorption was also greater from HYPO-ORS although potassium and glucose absorption were similar from both solutions. This study suggests that UK-ORS may not promote optimal water and solute absorption and that clinical studies with HYPO-ORS are indicated.
Hunt
J B
JB
Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, UK.
Elliott
E J
EJ
Farthing
M J
MJ
D000328:Adult; D004573:Electrolytes / Q000493:pharmacokinetics; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D007038:Hypotonic Solutions / Q000032:analysis / Q000494:pharmacology*; D007422:Intestines / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D010477:Perfusion; D015532:Rehydration Solutions / Q000032:analysis / Q000494:pharmacology*; D006113:United Kingdom; D014867:Water / Q000378:metabolism
D004573:Electrolytes; D007038:Hypotonic Solutions; D015532:Rehydration Solutions; D014867:Water; D005947:Glucose