title: Teicoplanin: Part 1. An evaluation of the concentrations seen in serum and the subcutaneous fat of the relatively ischaemic lower limb following a single intravenous bolus.
abstract: Teicoplanin is a new antibiotic currently undergoing clinical evaluation. Consecutive patients undergoing elective vascular surgery (n = 28) were randomised to receive a single intravenous bolus of 400 mg teicoplanin 1, 3, 6 or 12 h prior to surgery as prophylaxis against Gram-positive infection. Serum and fat antibiotic levels were measured and found to exceed the established MICs for common staphylococcal and streptococcal infections for at least 12 h following administration. This suggests that teicoplanin would be a useful choice of antibiotic in the prophylaxis and treatment of appropriate infections in elective surgery. By extrapolation, teicoplanin would also be of use in the prophylaxis and treatment of suitable infections seen in traumatised patients.
authors.affiliation: Department of Vascular Surgery, St. James's University Hospital, Leeds, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Antrum
authors.forename: S R
authors.initials: SR
authors.lastname: Bibby
authors.forename: C H
authors.initials: CH
authors.lastname: Ramsden
authors.forename: R C
authors.initials: RC
authors.lastname: Kester
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006020:Glycopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D007275:Injections, Intravenous; D007511:Ischemia / Q000503:physiopathology; D007866:Leg / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D012039:Regional Blood Flow; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin