Amino acids and peptides. XXIV. Synthesis of Neurospora crassa metallothionein and related cysteine-containing peptides and examination of their heavy metal-binding properties.
A pentacosapeptide corresponding to the entire amino acid sequence of Neurospora crassa metallothionein and several related cysteine-containing peptides were synthesized by the conventional solution method and their heavy metal-binding properties were examined. The Cu2+- or Cu+-binding properties of the various peptides were similar to each other, whereas the Cd2+-binding properties of these peptides were fairly structure-dependent.
Okada
Y
Y
Matsuno
Y
Y
Nishiyama
Y
Y
Tsuda
Y
Y
Iguchi
S
S
Min
K S
KS
Onosaka
S
S
Tanaka
K
K
D000595:Amino Acid Sequence; D003545:Cysteine / Q000378:metabolism; D008668:Metallothionein / Q000138:chemical synthesis*; D008670:Metals / Q000378:metabolism; D008969:Molecular Sequence Data; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000378:metabolism*; D010455:Peptides / Q000138:chemical synthesis; D011485:Protein Binding
D008670:Metals; D010455:Peptides; D008668:Metallothionein; D003545:Cysteine