title: Spontaneous switching of the sucrose-promoted colony phenotype in Streptococcus sanguis.
abstract: Streptococcus sanguis on media containing 3% sucrose gives rise to characteristic hard cohesive colonies (designated Spp+). Populations of Spp+ bacteria (strain Challis) on sucrose media switch to a soft noncohesive phenotype (designated Spp-) at a frequency of 10(-4) to 10(-3). Spp- bacteria switch back to Spp+ bacteria at a similar frequency. Successive rounds of Spp variation were observed. The Spp phenotypic switch was associated with changes in extracellular glucosyltransferase activity.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, University of Michigan, Ann Arbor 48109-0402.
authors.forename: G
authors.initials: G
authors.lastname: Tardif
authors.forename: M C
authors.initials: MC
authors.lastname: Sulavik
authors.forename: G W
authors.initials: GW
authors.lastname: Jones
authors.forename: D B
authors.initials: DB
authors.lastname: Clewell
mesh_terms: D005964:Glucosyltransferases / Q000378:metabolism; D006602:Hexosyltransferases / Q000378:metabolism; D013298:Streptococcus sanguis / Q000166:cytology* / Q000201:enzymology; D013395:Sucrose / Q000378:metabolism*; D001426:Bacterial Proteins
chemical_list: D005964:Glucosyltransferases; D006602:Hexosyltransferases; D013395:Sucrose; C021451:inulosucrase; D001426:Bacterial Proteins