Multiple steps are required for the induction of tumors by Abelson murine leukemia virus.
Helper virus-free Abelson murine leukemia virus (A-MuLV) was used to induce monoclonal pre-B-cell tumors in mice. The clonality, patterns of immunoglobulin heavy-chain gene rearrangement, tumorigenicity, and v-abl oncogene expression in individual preleukemic and leukemic colonies were compared. Our results indicate that A-MuLV preleukemic cells with low or undetectable tumorigenic potential give rise to leukemic cells with high tumorigenic potential by a process of subclone selection. The levels of v-abl oncogene product in preleukemic and leukemic cell populations were not significantly different. These results suggest that an additional event(s) unrelated to the level of the v-abl protein product is required for A-MuLV-transformed cells to become fully malignant.
Green
P L
PL
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Kaehler
D A
DA
Bennett
L M
LM
Risser
R
R
D000011:Abelson murine leukemia virus / Q000235:genetics / Q000472:pathogenicity*; D000818:Animals; D015139:Blotting, Southern; D002455:Cell Division; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D009856:Oncogene Proteins, Viral / Q000235:genetics; D011289:Preleukemia / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
D004273:DNA, Neoplasm; D009856:Oncogene Proteins, Viral