title: [Efficacy of propafenone in supraventricular arrhythmias].
abstract: We evaluated the results of intravenous administration of propafenone in 44 patients with rapid symptomatic supraventricular arrhythmia of less than 1 month duration. Mean age was 54 years and 22 were females. Propafenone, 2 mg/kg was given over 15 min and blood pressure and heart rate were monitored in the following hour. Sixteen out of 19 (84%) episodes of paroxysmal supraventricular tachycardia in 15 patients reverted to sinus rhythm at a mean interval of 11 min. None of 14 patients with atrial flutter reverted to sinus rhythm, but the ventricular rate decreased from 143 +/- 38 to 110 +/- 41 (p less than 0.02). The mechanism involved was slowing of the atrial cycle with associated increase A-V block in 7 patients. One patient experienced 1:1 conduction at a rate of 214 per min. Twenty seven % of 15 patients with atrial fibrillation reverted to sinus rhythm; ventricular rate decreased from 134 +/- 40 to 98 +/- 22 (p less than 0.05) in the remaining cases. There were no significant side effects of the drug and systolic blood pressure decreased from 109 +/- 27 to 99 +/- 30 beats per min (p less than 0.05) with no change in diastolic pressure.
authors.forename: R
authors.initials: R
authors.lastname: Kauffmann
authors.forename: J
authors.initials: J
authors.lastname: Goich
authors.forename: C
authors.initials: C
authors.lastname: Parra
authors.forename: A
authors.initials: A
authors.lastname: Ayala
authors.forename: F
authors.initials: F
authors.lastname: Manzur
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001282:Atrial Flutter / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000627:therapeutic use*; D011446:Prospective Studies; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
chemical_list: D011405:Propafenone
vernacular_title: Eficacia de propafenona en arritmias supraventriculares.