What mediates between beta-amyloid and paired helical filaments?
beta-Amyloid precedes helical filaments (PHF), and both appear to be relatively independent alterations, contrary to the previous view. One of the mediators between beta-amyloid and PHF should be a trophic factor(s). Unbalanced trophic activities in the AD brain result in massive sprouting of vulnerable neurons, leading to their exhaustion and death.
Ihara
Y
Y
Tokyo Metropolitan Institute of Gerontology, Japan.
D000682:Amyloid / Q000378:metabolism* / Q000502:physiology; D016229:Amyloid beta-Peptides; D003599:Cytoskeleton / Q000378:metabolism*; D004314:Down Syndrome / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism*
D000682:Amyloid; D016229:Amyloid beta-Peptides