title: Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon.
abstract: Diffuse thymic hyperplasia after chemotherapy of a mixed testicular germ cell tumor is reported in a 16-year-old patient. The immunohistologic investigation of the enlarged thymus revealed a normal distribution and antigen expression of lymphocytes and epithelial cells. There was no evidence of selective proliferation of lymphocytic or nonlymphocytic subpopulations within the thymus. Thus, our data corroborate the identification of thymic enlargement after chemotherapy as a simple rebound phenomenon.
authors.affiliation: Institute of Pathology, Klinikum Steglitz, Free University of Berlin, West Germany.
authors.forename: W
authors.initials: W
authors.lastname: Düe
authors.forename: K P
authors.initials: KP
authors.lastname: Dieckmann
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000032:analysis; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000601:surgery; D009919:Orchiectomy; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013934:Thymectomy; D013950:Thymus Gland / Q000032:analysis / Q000187:drug effects / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor