[Suppressor activity of bone marrow and spleen cells in C57Bl/6 mice during carcinogenesis induced by 7,12-dimethylbenz(a)anthracene].
The nonspecific suppressor activity of bone marrow cells (BMC) and spleen cells (SC) of C57B1/6 mice was studied at 7,12-dimethylbenz(a)anthracene-induced carcinogenesis. It is established that in the latent period of the tumour development and with its appearance the suppressor activity of BMC decreases, while SC-increases. The activity of the BMC suppressor factor which is determined by the inhibition of proliferation of mastocytoma P-815 cells in vitro did not change significantly.
Kusmartsev
S A
SA
Ogreba
V I
VI
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D013491:Suppressor Factors, Immunologic; D015127:9,10-Dimethyl-1,2-benzanthracene
Supressornaia aktivnost' kletok kostnogo mozga i selezenki mysheĭ linii C57Bl/6 pri kantserogeneze, indutsirovannom 7,12-dimetil- benz(a)antratsenom.