title: Effects of long-term streptozotocin diabetes on the contractile and histochemical properties of rat muscles.
abstract: Contractile and histochemical properties of soleus (a slow-twitch muscle) and extensor digitorum longus (EDL, a fast-twitch muscle) were studied in mature rats after 3 months of streptozotocin-induced diabetes. Results were compared with age- and weight-matched controls. Diabetes produced profound wasting of fast muscles and particularly of the fast glycolytic (FG) fibres. Slow muscle fibres, both within the mixed EDL and in soleus, were less atrophied. Strength performance of EDL was reduced by diabetes, but maintained in soleus. Diabetes was without effect on the time to peak tension (TTP) and half-relaxation time (HRT) of EDL. However it produced profound slowing of soleus muscles, particularly of the relaxation phase. Part of the slowing effect of diabetes may be related to a histochemically demonstrable loss of fast oxidative glycolytic (FOG) fibres in soleus. Histochemical staining for the oxidative marker succinic dehydrogenase (SDH) revealed marked disruption of reaction product distribution in soleus, indicating an impairment of oxidative capacity.
authors.affiliation: Department of Physiology, Marischal College, University of Aberdeen.
authors.forename: M
authors.initials: M
authors.lastname: Cotter
authors.forename: N E
authors.initials: NE
authors.lastname: Cameron
authors.forename: D R
authors.initials: DR
authors.lastname: Lean
authors.forename: S
authors.initials: S
authors.lastname: Robertson
mesh_terms: D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
chemical_list: D013311:Streptozocin