title: [The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits].
abstract: Measurements of penicillin concentrations in the blood sera and tissues of rabbits have revealed a reduction of this antibiotic levels as the doses of injected ascorbic acid grew. A combination of benzylpenicillin with ascorbic and nicotinic acids improved penicillin penetration into experimental animals' tissues.
authors.forename: V N
authors.initials: VN
authors.lastname: Bednova
authors.forename: S V
authors.initials: SV
authors.lastname: Rotanov
authors.forename: T I
authors.initials: TI
authors.lastname: Navolotskaia
authors.forename: T I
authors.initials: TI
authors.lastname: Milonova
authors.forename: E A
authors.initials: EA
authors.lastname: Orlina
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D009525:Niacin / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D010400:Penicillin G / Q000032:analysis / Q000493:pharmacokinetics*; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D009536:Niacinamide; D009525:Niacin; D001205:Ascorbic Acid; D010400:Penicillin G
vernacular_title: Vliianie nikotinamida, nikotinovoĭ i askorbinovoĭ kislot na kontsentratsiiu penitsillina v syvorotke krovi i tkaniakh krolikov.