title: Anti-hypertensive drugs non-specifically reduce "spontaneous" activation of blood platelets.
abstract: Abnormal activation of blood platelets may be a contributory factor in the accelerated vascular disease which occurs in hypertension. We investigated the effects of lowering blood pressure in 12 patients with mild hypertension on several aspects of platelet function, initially in a placebo-controlled, double-blind, cross-over study with nisoldipine, and subsequently in the same patients comparing nisoldipine with the patients' usual anti-hypertensive therapy. Values were compared with those from an age, sex-matched control population. Seven hypertensive patients with renal failure were also studied. Administration of nisoldipine reduced ex vivo "spontaneous" aggregation of blood platelets significantly, and a similar significant effect was seen when blood pressure was lowered by the patients usual anti-hypertensive therapy. "Spontaneous" aggregation occurring in the control population was similar to that in the treated hypertensives. Blood platelet count, and aggregation in response to ADP and adrenalin were unaffected by treatment. Median plasma beta thromboglobulin levels were significantly higher in the untreated hypertensive patients (43 ng ml-1) than in the controls (30 ng ml-1), and there was a trend to reduced values for beta thromboglobulin on treatment of the hypertension. These results indicate that blood platelet activity is enhanced in hypertension and that function returns towards normal when blood pressure is lowered by treatment.
authors.affiliation: University Department of Medicine, General Infirmary, Leeds, UK.
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: M A
authors.initials: MA
authors.lastname: Orchard
authors.forename: A A
authors.initials: AA
authors.lastname: Spencer
authors.forename: J A
authors.initials: JA
authors.lastname: Davies
authors.forename: C R
authors.initials: CR
authors.lastname: Prentice
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D007674:Kidney Diseases / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D015737:Nisoldipine / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D010978:Platelet Factor 4 / Q000187:drug effects; D001620:beta-Thromboglobulin / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D015737:Nisoldipine