title: Double-blind randomized trial of ACTH versus dexamethasone versus methylprednisolone in multiple sclerosis bouts. Clinical, cerebrospinal fluid and neurophysiological results.
abstract: 30 patients with acute exacerbations of multiple sclerosis were treated by ACTH, dexamethasone or methylprednisolone in a double-blind randomized study. Clinical parameters were assessed; cerebrospinal fluid and neurophysiological parameters (visual- and brainstem-evoked potentials) were evaluated at the beginning and at the end of treatment. Dexamethasone was more effective than ACTH and 6-methylprednisolone in shortening bout duration. Neither CSF nor neurophysiological parameters were significantly affected by therapy.
authors.affiliation: Department of Neurology, Istituto Neurologico C. Besta, Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Milanese
authors.forename: L
authors.initials: L
authors.lastname: La Mantia
authors.forename: A
authors.initials: A
authors.lastname: Salmaggi
authors.forename: A
authors.initials: A
authors.lastname: Campi
authors.forename: M
authors.initials: M
authors.lastname: Eoli
authors.forename: V
authors.initials: V
authors.lastname: Scaioli
authors.forename: A
authors.initials: A
authors.lastname: Nespolo
authors.forename: F
authors.initials: F
authors.lastname: Corridori
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D011897:Random Allocation
chemical_list: D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D008775:Methylprednisolone