Synthesis of 18F-labelled VP 16-213 and podophyllotoxin using acetyl hypofluorite.
The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using [18F]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational changes.
Visser
G W
GW
Radio-Nuclide-Centre (RNC), Free University, Amsterdam, The Netherlands.
Bijma
A T
AT
Dijksman
J A
JA
Herscheid
J D
JD
D000085:Acetates; D004952:Esters; D005047:Etoposide / Q000031:analogs & derivatives*; D005461:Fluorine; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D008968:Molecular Conformation; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
D000085:Acetates; D004952:Esters; D005462:Fluorine Radioisotopes; D005461:Fluorine; D005047:Etoposide; C040801:acetyl hypofluorite; D011034:Podophyllotoxin