[Use of a volatile substrate to explore oxidative metabolism of xenobiotics in the rabbit lung].
A demethylation breath test was modeled in rabbits receiving 14C-anisole either by the intravenous route or by inhalation. The exhalation rate of 14CO2 was measured in a metabolic cage. The modeling hypothesis involved two metabolic compartments: a "central" compartment receiving the infusion, and a "pulmonary" compartment receiving the inhalation. The modeling succeeded in identifying a highly significant metabolic contribution of the lungs following inhalation of the substrate.
Kourad
A
A
Centre Hospitalier Universitaire, Laboratoire de Pharmacologie Clinique, Montpellier.
Terol
A
A
Alric
R
R
D000280:Administration, Inhalation; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007262:Infusions, Intravenous; D008168:Lung / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits; D015262:Xenobiotics / Q000378:metabolism*
D000840:Anisoles; D015262:Xenobiotics
Utilisation d'un substrat volatil pour explorer le métabolisme oxydatif des xénobiotiques par le poumon chez le lapin.