Spiramycin versus penicillin V in the empiric treatment of bacterial tonsillitis.
The efficacy and safety of spiramycin were compared with those of penicillin V in the treatment of 55 patients with acute bacterial tonsillitis. The most frequently isolated pathogens were streptococci and about one-third were group A/beta haemolytic streptococci. There was one clinical failure in the patients treated with penicillin, and none with spiramycin. No side effects were reported in either of the treatment groups. Thus in this study, spiramycin proved to be equivalent to penicillin in the treatment of acute bacterial tonsillitis in adults.
Manolopoulos
L
L
Adamopoulos
C
C
Tzagaroulakis
A
A
Maragoudakis
P
P
Kaffes
T
T
D000208:Acute Disease; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010404:Penicillin V / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D015572:Spiramycin / Q000627:therapeutic use*; D014069:Tonsillitis / Q000188:drug therapy* / Q000382:microbiology
D015572:Spiramycin; D010404:Penicillin V