Mechanism of LHRH analogue action in uterine fibroids.
Luteinising hormone-releasing hormone analogues have been found to reduce the size of uterine fibroids. Further studies are required to determine their exact mechanism of action. However, they are known to induce hypo-oestrogenism, which leads to reduction in uterine arterial blood flow, one mechanism by which reduction of fibroid size is thought to occur.
Shaw
R W
RW
Academic Department of Obstetrics and Gynaecology, Royal Free Hospital School of Medicine, London, UK.
D002064:Buserelin / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017273:Goserelin; D006801:Humans; D007889:Leiomyoma / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D017274:Nafarelin; D014594:Uterine Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology
D017273:Goserelin; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D002064:Buserelin