Additive inhibitory effect of cyclosporine and verapamil may occur through different mechanisms that may be dependent or independent of the slow calcium channel.
Weir
M R
MR
Division of Nephrology, University of Maryland Hospital, Baltimore 21201.
Peppler
R
R
Gomolka
D
D
Handwerger
B S
BS
D000328:Adult; D002118:Calcium / Q000097:blood*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D014700:Verapamil / Q000494:pharmacology*
D015220:Calcium Channels; D003524:Cyclosporins; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014700:Verapamil; D002118:Calcium