Pasteurisation of a factor I (C3b inactivator) concentrate from human plasma.
A method of pasteurising a concentrate of factor I (C3b inactivator) prepared from human blood plasma is described. As well as obtaining a high yield of factor I by this virus inactivation procedure it is furthermore possible, by adjustment of the stabiliser concentration, to obtain a very pronounced reduction in the concentration of factor B, a component of the complement system which is unwanted in the treatment of factor I deficiency. The product so produced is in two respects superior to plasma infusions for factor I replacement therapy: it has been submitted to virus inactivation and factor B depletion.
Alsøe
K O
KO
Biopharmaceuticals Division, Novo-Nordisk a/s, Gentofte, Denmark.
Kihl
J
J
D017244:Complement Factor I; D004340:Drug Contamination; D005998:Glycine; D006358:Hot Temperature; D006801:Humans; D008239:Lysine; D012697:Serine Endopeptidases / Q000302:isolation & purification*; D013012:Sorbitol; D013395:Sucrose
D013012:Sorbitol; D013395:Sucrose; D012697:Serine Endopeptidases; D017244:Complement Factor I; D008239:Lysine; D005998:Glycine