title: A decreased capacity of hepatic growth hormone (GH) receptors and failure of thyrotrophin-releasing hormone to stimulate the peripheral conversion of thyroxine into triiodothyronine in sex-linked dwarf broiler hens.
abstract: The effect of two different doses of thyrotrophic releasing hormone (TRH) upon the plasma levels of growth (GH) and thyroid hormones in both sex-linked dwarf (dw) and normal (Dw) broiler hens was determined. In normal hens, 1.5 and 24 microg TRH/kg increased the GH plasma concentrations after 15 min. Plasma concentrations of T3 increased significantly 1 h after TRH injection, whereas T4 concentration decreased after 2 following injection of 24 microg/kg TRH. In dwarf hens both doses of TRH increased the plasma concentrations of GH and the GH response lasted longer. However, TRH was ineffective in raising T3 and T4 levels. Saline-injected dwarf birds showed no differences in plasma T4 and T3 levels in comparison with normal hens. A smaller number of hepatic cGH receptors was found in dwarf hens, whereas the affinity of the hepatic GH receptor was not influenced by the genotype. It is concluded that the sex-linked dwarf broiler hen is unable to respond to a TRH-induced GH stimulus probably because of a deficiency in hepatic GH receptors resulting in a failure to stimulate the T4 to T3 converting activity.
authors.affiliation: Catholic University of Leuven, Belgium.
authors.forename: E R
authors.initials: ER
authors.lastname: Kühn
authors.forename: L M
authors.initials: LM
authors.lastname: Huybrechts
authors.forename: A
authors.initials: A
authors.lastname: Vanderpooten
authors.forename: L
authors.initials: L
authors.lastname: Berghman
mesh_terms: D000818:Animals; D002645:Chickens; D004392:Dwarfism / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D013006:Growth Hormone / Q000097:blood; D008099:Liver / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D011986:Receptors, Somatotropin; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D013974:Thyroxine