Complement receptor (CR1) and IgG or IgA on erythrocytes and in circulating immune complexes in patients with glomerulonephritis.
This study reports the quantitative analysis of complement receptor (CR1) molecules on erythrocyte surface, the amount of immunoglobulin-containing material (IgG-IC and IgA1-IM) on the erythrocyte surface, and the concentrations of circulating immune complexes (IgG-CIC and IgA-CIC); also reported are the HLA phenotypes of 44 patients affected by various forms of glomerulonephritis (including 20 primary IgA nephropathy, 11 membranous glomerulonephritis, 9 lupus nephritis and 4 renal vasculitis). Erythrocyte CR1 molecules were found to be decreased (P less than 0.02) and erythrocyte IgG-IC were less than in controls (P less than 0.025) in lupus nephritis patients, whereas IgG-CIC were significantly greater (P less than 0.02). In patients affected by primary IgA nephropathy, mean erythrocyte CR1 concentrations were significantly decreased (P less than 0.02). Patients with impaired renal function had mean erythrocyte CR1 values significantly greater than those with normal renal function (P less than 0.002). Immunoglobulin-containing material on the erythrocyte surface was not significantly increased, whereas the serum concentrations of both IgA-CIC and IgG-CIC were significantly increased (P less than 0.02). In membranous nephropathy erythrocyte CR1 molecules were quantitatively similar to control data and no increase in CIC was observed. Conversely, erythrocyte IgG-IC were significantly increased (P less than 0.01). No significant relationship among erythrocyte CR1 molecules, erythrocyte surface-associated immunoglobulins, CIC, and HLA phenotype was observed in any patient group.
Coppo
R
R
Medical Nephrology, University of Turin, Italy.
Amore
A
A
Roccatello
D
D
Amoroso
A
A
Maffei
S
S
Quattrocchio
G
G
Molino
A
A
Gianoglio
B
B
Piccoli
G
G
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011951:Receptors, Complement / Q000032:analysis*
D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011951:Receptors, Complement