title: Macroporous calcium phosphate bioceramics in dog femora: a histological study of interface and biodegradation.
abstract: This study examines the biodegradation behaviour of calcium phosphate macroporous bioceramics consisting of hydroxylapatite or beta-whitlockite implants. The implantations were performed in hard tissue of femora and muscular tissue of dogs for periods of 6 and 12 month. With microradiography and light microscopy, respectively, of ground and thin sections it was shown that hydroxylapatite remained unchanged and beta-whitlockite degraded within 6 month in bone tissue. In the muscular tissue, the biodegradation of beta-whitlockite was slower. In addition, beta-whitlockite gave rise to a cellular response of lymphocytes and plasma cells rather than hydroxylapatite in the soft tissue region. For tissue response hydroxylapatite is more suitable as an implant material than beta-whitlockite.
authors.affiliation: Department of Biomaterial Sciences, ACTA, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: C P
authors.initials: CP
authors.lastname: Klein
authors.forename: P
authors.initials: P
authors.lastname: Patka
authors.forename: W
authors.initials: W
authors.lastname: den Hollander
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001862:Bone Resorption; D001842:Bone and Bones / Q000601:surgery*; D002130:Calcium Phosphates; D002516:Ceramics; D004285:Dogs; D017886:Durapatite; D005269:Femur / Q000473:pathology / Q000601:surgery; D006882:Hydroxyapatites; D009132:Muscles / Q000473:pathology; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C021767:whitlockite; D017886:Durapatite