The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells.
The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant increase in ALA synthase activity. Interleukin-6 increased ALA synthase activity only slightly, but it substantially potentiated the induction of ALA synthase by Me2SO. These data suggest that ALA synthase activity in liver is altered during acute-phase reactions.
Iwasa
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F
Rockefeller University Hospital, New York, NY 10021.
Sassa
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S
Kappas
A
A
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000209:etiology; D001685:Biological Factors / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6; D007378:Interleukins / Q000494:pharmacology; D008113:Liver Neoplasms / Q000201:enzymology*; D008262:Macrophage Activation; D015846:Monokines; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D001685:Biological Factors; D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D015846:Monokines; D014409:Tumor Necrosis Factor-alpha; D000624:5-Aminolevulinate Synthetase; D004121:Dimethyl Sulfoxide