title: Sleep initiation and initial sleep intensity: interactions of homeostatic and circadian mechanisms.
abstract: Sleep initiation and sleep intensity in humans show a dissimilar time course. The propensity of sleep initiation (PSI), as measured by the multiple sleep latency test, remains at a relatively constant level throughout the habitual period of waking or exhibits a midafternoon peak. When waking is extended into the sleep period, PSI rises rapidly within a few hours. In contrast, sleep intensity, as measured by electroencephalographic slow-wave activity during naps, shows a gradual increase during the period of habitual waking. In the two-process model of sleep regulation, it corresponds to the rising limb of the homeostatic Process S. We propose that PSI is determined by the difference between Process S and the threshold H defining sleep onset, which is modulated by the circadian process C. In contrast to a previous version of the model, the parameters of H (amplitude, phase, skewness) differ from those of threshold L, which defines sleep termination. The present model is able to simulate the time course of PSI under baseline conditions as well as following recovery sleep after extended sleep deprivation. The simulations suggest that during the regular period of waking, a circadian process counteracts the increasing sleep propensity induced by a homeostatic process. Data obtained in the rat indicate that during the circadian period of predominant waking, a circadian process prevents a major intrusion of sleep.
authors.affiliation: Institute of Pharmacology, University of Zürich, Switzerland.
authors.forename: A A
authors.initials: AA
authors.lastname: Borbély
authors.forename: P
authors.initials: P
authors.lastname: Achermann
authors.forename: L
authors.initials: L
authors.lastname: Trachsel
authors.forename: I
authors.initials: I
authors.lastname: Tobler
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D006706:Homeostasis; D006801:Humans; D008960:Models, Psychological; D011930:Reaction Time; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology; D012894:Sleep Stages; D013997:Time Factors