[Prevention of cisplatin nephrotoxicity in cancer: adjusting the dosage with a computerized chrono-pump].
Platinum and its derivates are particularly efficient in treatment of ovarian and testis carcinomas. Nevertheless, the high nephrotoxicity of these drugs limits their use. It is known that nephrotoxicity appears when platinum plasmatic concentrations are higher than 1.5 mg/l. Moreover, the wide variability between patients and between cures, emphasizes the difficulties of utilization. Using a computerized pump and a program for individual dosage regimen, an efficient prevention of plasmatic overdosages have been realised and nephrotoxicity accidents have been avoided.
Gestin-Boyer
C
C
INSERM-CNRS, Centre Val d'Aurelle II, Montpellier.
René
C
C
Cupissol
D
D
Tep
A
A
Bressolle
F
F
Bres
J
J
Brun
S
S
Serrou
B
B
Pujol
H
H
D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy; D013813:Therapy, Computer-Assisted / Q000379:methods*
D002945:Cisplatin
Prévention de la néphrotoxicité du cisplatine en cancérologie: ajustement de posologie par chrono-pompe programmable.