Long-term use of the low dose LHRH analogue combined with monthly medroxy-progesterone administration.
In a pilot study, chronic pelvic pain associated with endometriosis, dysmenorrhoea or menorrhagia has been treated for prolonged periods with low dose buserelin (daily) and medroxy-progesterone (monthly). The partial inhibition of ovarian function was effective in relieving pain and controlling uterine bleeding, with few side effects. There was no change in serum cholesterol level. A possible small bone demineralisation effect has been observed.
Lemay
A
A
St-François d'Assise Hospital, Department of Obstetrics and Gynaecology, Laval University, Quebec, P.Q., Canada.
Dodin Dewailly
S
S
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004412:Dysmenorrhea / Q000188:drug therapy*; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D008595:Menorrhagia / Q000188:drug therapy*
D008525:Medroxyprogesterone; D002064:Buserelin