Urinary excretion of meso-2,3-dimercaptosuccinic acid in human subjects.
The urinary excretion of meso-2,3-dimercaptosuccinic acid (DMSA), which is an effective chelating agent for lead, was determined after the oral administration of 10 mg DMSA/kg to six normal young men. The DMSA that was absorbed was extensively biotransformed. After 14 hours only 2.53% of the administered DMSA was excreted in the urine as unaltered DMSA and 18.1% as altered forms. The unaltered DMSA was 12% of the total DMSA found in the urine. The altered form(s) of DMSA was 88% of the total urinary DMSA. The altered DMSA can be converted to unaltered DMSA by electrolytic reduction, which indicates that the altered forms of DMSA are disulfides. The excretion of altered DMSA reached a peak between 2 and 4 hours after DMSA administration. There were small but statistically significant increases in the excretion of zinc, copper, and lead after DMSA administration. DMSA did not influence the urinary excretion of 27 other metals and elements.
Aposhian
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Department of Molecular and Cellular Biology, College of Medicine, University of Arizona, Tucson 85721.
Maiorino
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Dart
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Perry
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D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004220:Disulfides / Q000652:urine; D006801:Humans; D008297:Male; D008670:Metals / Q000652:urine; D008903:Minerals / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013048:Specimen Handling; D013054:Spectrophotometry, Atomic; D004113:Succimer / Q000493:pharmacokinetics* / Q000652:urine; D013438:Sulfhydryl Compounds / Q000493:pharmacokinetics*
D004220:Disulfides; D008670:Metals; D008903:Minerals; D013438:Sulfhydryl Compounds; D004113:Succimer