title: The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution.
abstract: The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.
authors.affiliation: Laboratory of Molecular Biophysics, Oxford, UK.
authors.forename: R
authors.initials: R
authors.lastname: Acharya
authors.forename: E
authors.initials: E
authors.lastname: Fry
authors.forename: D
authors.initials: D
authors.lastname: Stuart
authors.forename: G
authors.initials: G
authors.lastname: Fox
authors.forename: D
authors.initials: D
authors.lastname: Rowlands
authors.forename: F
authors.initials: F
authors.lastname: Brown
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000648:ultrastructure*; D005075:Biological Evolution; D002213:Capsid / Q000276:immunology / Q000648:ultrastructure; D003198:Computer Simulation; D008969:Molecular Sequence Data; D010849:Picornaviridae / Q000648:ultrastructure; D014764:Viral Proteins / Q000032:analysis; D014765:Viral Vaccines; D014961:X-Ray Diffraction
chemical_list: D014764:Viral Proteins; D014765:Viral Vaccines