[Secreted interleukin-2 receptor as a parameter of the activity of sarcoidosis].
Serum sIL-2-R levels were measured in 28 sarcoidosis patients at multiple time points before, during, and after therapy, with a mean follow-up time of 10.2 +/- 5.2 months, and the results compared with the clinical activity of the disease. Before therapy, 20 out of 24 episodes with active disease exhibited elevated levels of sIL-2-R (918 +/- 362 U/ml). In inactive disease after tapering off corticoid therapy the sIL-2-R levels were 453 +/- 274 U/ml. Disease activity under therapy also correlated with sIL-2-R serum levels. 23 out of 29 episodes with signs of activity under therapy had elevated sIL-2-R levels (808 +/- 409 U/ml). Only three of 28 patients in whom disease activity ceased after therapy had been initiated had raised sIL-2-R levels (mean: 401 +/- 140 U/ml). These results demonstrate that the activity of pulmonary sarcoidosis is reflected accurately by the serum levels of sIL-2-R, suggesting that the course of the disease can be monitored by this approach.
Strausz
J
J
Abteilung Innere Medizin mit Schwerpunkt Pneumologie, Universität Mainz.
Müller-Quernheim
J
J
Ferlinz
R
R
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012008:Recurrence; D012507:Sarcoidosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D015375:Receptors, Interleukin-2; D007703:Peptidyl-Dipeptidase A
Sezernierter Interleukin-2-Rezeptor als Aktivitätsparameter der Sarkoidose.