[Dependence of hypoxic changes in macro- and micro-hemodynamics on the activity of adrenoreceptors in the skeletal muscle in hypothermia].
Dependence of hypoxic changes of macro- and microcirculation on the activity of adrenergic receptors in the cooled organism was studied on decentralized shank of cat under perfusion with constant blood flow. After cooling of cat (to 30 degrees C) and blockade of alpha-adrenoreceptors hypoxic hypoxia (10% O2 in N2) caused (a) much greater reduction of precapillary resistance of shank, (b) more striking (by 3 times) increase of capillary filtration coefficient and (c) the increase of capillary pressure and postcapillary resistance in contrast to their decrease to hypoxia under hypothermia before alpha-blockade. Beta-adrenoreceptor blockade had no influence on the changes of the resistance and exchange function of skeletal muscle blood vessels evoked by hypoxia under cooling.
Nurmatov
A A
AA
Kudriashov
Iu A
IuA
Tkachenko
B I
BI
D000818:Animals; D001775:Blood Circulation; D002415:Cats; D004088:Dihydroergotoxine / Q000494:pharmacology; D005260:Female; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D008297:Male; D008833:Microcirculation; D009132:Muscles / Q000098:blood supply / Q000294:innervation*; D010100:Oxygen / Q000097:blood*; D010646:Phentolamine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004088:Dihydroergotoxine; D010100:Oxygen; D010646:Phentolamine
Zavisimost' gipoksicheskikh sdvigov makro- i mikrogemodinamiki ot aktivnosti adrenoretseptorov v skeletnoĭ myshtse okhlazhdennogo organizma.