Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection.
Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2Kd was downregulated, while H-2Dd was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c x SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class II antigen expression was unchanged following MHV-4 infection. Virus-induced MHC class I modulation is genetically regulated, and may influence virus clearance by class I-dependent CTL.
Joseph
J
J
Department of Neurology, Jefferson Medical College, Philadelphia, PA 19107.
Knobler
R L
RL
Lublin
F D
FD
Hart
M N
MN
D000818:Animals; D001921:Brain / Q000166:cytology / Q000276:immunology*; D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D005434:Flow Cytometry; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus / Q000276:immunology
D015395:Histocompatibility Antigens Class I