[Antitubercular agents. 45. Antimycobacterial thiohydrazide].
The present paper investigates the activity of thiohydrazides containing a structural fragment of oxalic acid against Mycobacterium tuberculosis and Mycobacterium kansasii. The drugs included heterocyclic compounds as well. All compounds under study show medium activity. The minimal inhibition concentrations against Mycobacterium kansasii are approximately 3 times higher than against Mycobacterium tuberculosis. The most effective aromatic compounds have the RM values (silica gel impregnated with silicon oil-water) in the interval of 2.2-2.6.
Waisser
K
K
Lehrstuhl für anorganische und organische Chemie, Pharmazeutische Fakultät der Karls-Universität, Hradec Králové, DDR.
Odlerová
Z
Z
Houngbedji
N
N
Thiel
W
W
Mayer
R
R
D000995:Antitubercular Agents / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D006834:Hydrazines / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D010070:Oxalates / Q000494:pharmacology*; D019815:Oxalic Acid; D012044:Regression Analysis
D000995:Antitubercular Agents; D006834:Hydrazines; D010070:Oxalates; D019815:Oxalic Acid
Antituberkulotika. 45. Mitteilung: Antimykobakterielle Thiohydrazide.