title: Determination of lovastatin acid in serum by gas chromatography/mass spectrometry.
abstract: The acid form of lovastatin, an HMG-CoA reductase inhibitor, was analyzed by gas chromatography/negative-ion chemical ionization mass spectrometry after derivatization with pentafluorobenzyl bromide and bis-(trimethylsilyl)trifluoroacetamide (BSTFA). Mass spectrometry of this derivative produced a dominant [M-181]- ion under chemical ionization conditions using ammonia as the reagent gas. The limit of detection was approximately 2 pg injected on column.
authors.affiliation: Squibb Institute for Medical Research, Analytical Research and Development, New Brunswick, New Jersey 08903.
authors.forename: D
authors.initials: D
authors.lastname: Wang-Iverson
authors.forename: E
authors.initials: E
authors.lastname: Ivashkiv
authors.forename: M
authors.initials: M
authors.lastname: Jemal
authors.forename: A I
authors.initials: AI
authors.lastname: Cohen
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: C040295:mevinolinic acid; D008148:Lovastatin