title: Dopamine-induced relaxation in human pulmonary arteries.
abstract: Dose-dependent relaxations were induced by dopamine in human pulmonary arteries that had been contracted with prostaglandin F2 alpha without alpha-adrenergic blocking agents. The dopamine-induced relaxation was inhibited by haloperidol and fluphenazine, but not by domperidone, suggesting that this relaxation was mediated via DA1 receptors.
authors.affiliation: Department of Pharmacology, Shimane Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Nakase
mesh_terms: D000368:Aged; D015237:Dinoprost / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology; D017447:Receptors, Dopamine D1
chemical_list: D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D004294:Domperidone; D015237:Dinoprost; D006220:Haloperidol; D005476:Fluphenazine; D004298:Dopamine; D009638:Norepinephrine