title: Control of hypertension and reversal of renal failure in undifferentiated connective tissue disease by enalapril.
abstract: Activation of the renin angiotensin system is important in the development of accelerated hypertension and progression to acute renal failure in scleroderma and undifferentiated connective tissue disease. Inhibition of angiotensin-converting enzyme activity may effectively control blood pressure and ameliorate renal insufficiency. To our knowledge, we describe the first reversal of dialysis-dependent renal insufficiency by enalapril maleate and recovery and maintenance of near-normal renal function in a patient suffering from undifferentiated connective tissue disease with sclerodermatous features. The pathophysiologic mechanisms and long-term treatment implications with angiotensin-converting enzyme inhibitors in this setting are discussed.
authors.affiliation: Department of Medicine, University of Massachusetts Medical Center, Worcester 01655-2397.
authors.forename: S L
authors.initials: SL
authors.lastname: Strongwater
authors.forename: E G
authors.initials: EG
authors.lastname: Galvanek
authors.forename: J S
authors.initials: JS
authors.lastname: Stoff
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use; D003240:Connective Tissue Diseases / Q000150:complications*; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D012084:Renin-Angiotensin System
chemical_list: D004656:Enalapril; D002216:Captopril