title: [Immunologic aspects of the pathogenesis of latent and seroresistant forms of syphilis].
abstract: Studies of the cellular and humoral immunity in patients with latent and seroresistant syphilis have revealed decreased content of T-lymphocytes and elevated levels of B- and antigen-reactive lymphocytes. Reduced T-cell level is due to a decrease of the T-suppressor subpopulation. Unlike latent syphilis, seroresistant form is associated with a complete disappearance of the theophylline-sensitive subpopulation, whereas T-lymphocytes are represented mainly by the theophylline-resistant (helper) subpopulation. Effective therapy of patients with seroresistant syphilis has normalized the counts of T- and B-antigen-reactive lymphocytes, and theophylline-sensitive cells appear in the blood. These data give grounds to prescribe immunostimulating therapy to patients with seroresistant syphilis.
authors.forename: L T
authors.initials: LT
authors.lastname: Shetsiruli
authors.forename: N V
authors.initials: NV
authors.lastname: Gogebashvili
authors.forename: K S
authors.initials: KS
authors.lastname: Toniia
mesh_terms: D000328:Adult; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013587:Syphilis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D013592:Syphilis, Latent / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
vernacular_title: Immunologicheskie aspekty patogeneza skrytykh i serorezistentnykh form sifilisa.