title: [Familial occurrence of leukemia. Cytogenetic considerations apropos of 2 cases].
abstract: The authors describe a case of family leukemia: an acute myeloid leukemia preceded by Pelger's anomaly in a 77 year old brother and a chronic myeloid leukemia chromosome Ph + in a 71 years old sister, sixteen years after the first one. The authors formulate a hypothesis that both haematologic diseases may have in common a mistake of transcription caused by an anomalous m RNA.
authors.forename: G M
authors.initials: GM
authors.lastname: Spanò
authors.forename: R
authors.initials: R
authors.lastname: Barletta
authors.forename: E
authors.initials: E
authors.lastname: Fiorentino
authors.forename: P
authors.initials: P
authors.lastname: De Pedrini
authors.forename: F
authors.initials: F
authors.lastname: Meloni
authors.forename: R
authors.initials: R
authors.lastname: Rapisarda
authors.forename: M G
authors.initials: MG
authors.lastname: Transi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D008297:Male; D010381:Pelger-Huet Anomaly / Q000150:complications; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger
vernacular_title: Familiarità leucemica. Considerazioni citogenetiche a proposito di due casi.