Use of progestins.
The question that still remains today is, What is an ideal formulation for administering estrogens? There have been no large-scale, long term studies to answer this question. But the pendulum appears to be swinging from cyclic combination therapy, or sequential combination therapy, to continuous therapy. There is less bleeding and compliance is better. There is no difference in the effects on lipids, and it looks as though the endometrium maintains its atrophy. The future in developing the ideal formulation may lie in this direction; however, more studies need to be coordinated and done in several centers.
Mishell
D R
DR
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D045166:Estradiol Congeners / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives; D017258:Medroxyprogesterone Acetate; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000077563:Norethindrone Acetate; D009644:Norgestrel / Q000008:administration & dosage; D011372:Progestins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D045166:Estradiol Congeners; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D008055:Lipids; D011372:Progestins; D009644:Norgestrel; D004958:Estradiol; D000077563:Norethindrone Acetate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D009640:Norethindrone