title: Supernormal ejection performance is isolated to the ipsilateral congenitally pressure-overloaded ventricle.
abstract: Congenital left ventricular pressure overload is associated with "excessive" hypertrophy that leads to subnormal afterload (wall stress), permitting enhanced ventricular ejection performance. Whether congenital right ventricular pressure overload is associated with a similar phenomenon is uncertain. It is also unknown whether supranormal ejection performance affects only the overloaded ventricle or is a general process affecting both ventricles. Conflicting data exist about whether the hypertrophic process associated with pressure overload is induced primarily by local loading conditions or by neuroendocrine influences. If the former postulate is true, the hypertrophic response should be confined to the overloaded ventricle; if the latter is true, one might predict that both ventricles would be affected by a less specific response to circulating catecholamines. To help resolve these issues, both right and left ventricular performance was examined in seven patients with isolated congenital pulmonary stenosis (average pulmonary pressure gradient 78 +/- 13 mm Hg), six patients with isolated congenital aortic stenosis (average gradient 80 +/- 10 mm Hg) and six normal subjects. Right ventricular ejection fraction was increased in patients with pulmonary stenosis (61 +/- 2%) compared with the value in normal subjects (53 +/- 2%, p less than 0.01) and in patients with aortic stenosis (50 +/- 3%, p = 0.007). Left ventricular ejection fraction was increased in patients with congenital aortic stenosis (84 +/- 4%) compared with the value in normal subjects (70 +/- 4%, p less than 0.01) and in patients with congenital pulmonary stenosis (65 +/- 2%, p less than 0.002).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston 29425.
authors.forename: R B
authors.initials: RB
authors.lastname: Leman
authors.forename: F G
authors.initials: FG
authors.lastname: Spinale
authors.forename: G W
authors.initials: GW
authors.lastname: Dorn
authors.forename: G
authors.initials: G
authors.lastname: Cooper
authors.forename: J F
authors.initials: JF
authors.lastname: Spann
authors.forename: P C
authors.initials: PC
authors.lastname: Gillette
authors.forename: B A
authors.initials: BA
authors.lastname: Carabello
mesh_terms: D001024:Aortic Valve Stenosis / Q000151:congenital* / Q000503:physiopathology; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology; D002648:Child; D006801:Humans; D009200:Myocardial Contraction; D011666:Pulmonary Valve Stenosis / Q000151:congenital* / Q000503:physiopathology; D013318:Stroke Volume