title: Decreased fibrinolytic response to adrenergic stimulation in hypertensive patients.
abstract: The aim of this study was to assess the function of the fibrinolytic system at rest and in response to adrenergic stimulation in patients with stable essential hypertension as compared with normotensives. At rest, essential arterial hypertensives were characterized by increased levels of circulating tissue-plasminogen activator, associated with an increased activity of its specific inhibitor, the PAI-1. After stress, fibrinolytic response was impaired in essential arterial hypertensives despite a greater release of tissue plasminogen activator by endothelial cells. Therefore, the PAI-1 activity may be increased in essential arterial hypertensives not only at rest, but also after stress. This may represent a risk factor for hypertensive patients.
authors.affiliation: Clinica Medica, L. Sacco Hospital, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Palermo
authors.forename: P
authors.initials: P
authors.lastname: Bertalero
authors.forename: N
authors.initials: N
authors.lastname: Pizza
authors.forename: R
authors.initials: R
authors.lastname: Amelotti
authors.forename: A
authors.initials: A
authors.lastname: Libretti
mesh_terms: D000328:Adult; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008606:Mental Processes / Q000502:physiology; D015849:Plasminogen Inactivators / Q000097:blood; D011941:Receptors, Adrenergic / Q000502:physiology*; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D015849:Plasminogen Inactivators; D011941:Receptors, Adrenergic; D010959:Tissue Plasminogen Activator; D004837:Epinephrine