title: [The role of nitroglycerin in limiting the area of necrosis in myocardial infarction].
abstract: Clinical course of myocardial infarction and prognosis depend mainly on the extent of necrosis. A large number of cells in the neurotic zone, despite metabolic changes and contractility disorders may be salvaged providing that the treatment is initiated early enough. Intravenous nitroglycerin is one of the available agents used in limiting infarct size. Its beneficial effects on the myocardial cells in the border zone of the infarct result from a reduction in ventricular preload and afterload, an improvement of myocardial compliance and ventricular contractile function as well as from a redistribution of myocardial blood flow. The direct action of nitroglycerin on the coronary arteries and collaterals without "steal effecta" is also of importance. The results of clinical experiments with intravenous nitroglycerin in acute myocardial infarction are encouraging. By using various techniques to estimate the amount of salvage in the myocardium at risk various authors report a 30-41% salvage with nitroglycerin therapy.
authors.forename: J
authors.initials: J
authors.lastname: Grodecki
mesh_terms: D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D005996:Nitroglycerin / Q000627:therapeutic use*
chemical_list: D005996:Nitroglycerin
vernacular_title: Rola nitrogliceryny w ograniczeniu strefy martwicy zawału mieśnia serca.