title: Selective and enantiospecific acylation of kappa opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexy l] benzeneacetamide. Demonstration of kappa receptor heterogeneity.
authors.affiliation: Section on Drug Design and Synthesis, National Institute of Digestive, Diabetes and Kidney Diseases, Bethesda, Maryland 20892.
authors.forename: B R
authors.initials: BR
authors.lastname: de Costa
authors.forename: R B
authors.initials: RB
authors.lastname: Rothman
authors.forename: V
authors.initials: V
authors.lastname: Bykov
authors.forename: A E
authors.initials: AE
authors.lastname: Jacobson
authors.forename: K C
authors.initials: KC
authors.lastname: Rice
mesh_terms: D000215:Acylation; D000818:Animals; D044482:Benzeneacetamides; D001575:Benzomorphans / Q000378:metabolism; D003510:Cyclohexanes / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D011759:Pyrrolidines / Q000378:metabolism / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000378:metabolism*; D017473:Receptors, Opioid, kappa; D013237:Stereoisomerism
chemical_list: D044482:Benzeneacetamides; D001575:Benzomorphans; D003510:Cyclohexanes; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; C058445:2-isothiocyanato-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)benzeneacetamide; C027248:bremazocine; C045444:U 69593