Antibodies to simian virus 5 in patients with multiple sclerosis and other neurological disorders.
Antibodies to the paramyxovirus simian virus 5 were measured in cerebrospinal fluid samples using an enzyme-linked immunosorbent assay. Six of the 13 clinically definite MS patients had elevated levels of antibodies compared with other neurological disease and orthopaedic controls. None of the samples from MS patients classed as probable or possible had increased amounts of SV5 antibodies. Simian virus 5 antibodies and measles antibodies showed a weak correlation and it is suggested that the elevated levels of the former are a manifestation of the increased antiviral response found in some MS patients.
Brankin
B
B
Department of Biochemistry, Queen's University, Belfast, Northern Ireland, U.K.
Wisdom
G B
GB
Allen
I V
IV
Hawkins
S A
SA
Cosby
S L
SL
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000382:microbiology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000382:microbiology; D015301:Retroviruses, Simian / Q000276:immunology*
D000914:Antibodies, Viral