Differentiation of T cells into helper cells from immature precursors: identification of a target cell for a proline-rich polypeptide (PRP).
We demonstrated, with the aid of PRP, that precursors of helper T cells in the humoral immune response to SRBC belong to a minor thymocyte subset bearing the: Thy-1 +/-, H-2+, L3T4-, lyt 2-, CD3- phenotype. We showed, in addition, that PRP induced among the double negative (L3T4-, lyt 2-) thymocytes an appearance of differentiation antigens such as: L3T4, lyt 2, CD3 and T-cell receptor (alpha/beta). The data presented in this paper are in accordance with the present view on the process of T-cell maturation.
Wieczorek
Z
Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Zimecki
M
M
Spiegel
K
K
Lisowski
J
J
Janusz
M
M
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002454:Cell Differentiation; D010455:Peptides; D055232:Proline-Rich Protein Domains; D051381:Rats; D013601:T-Lymphocytes / Q000166:cytology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology*; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology*
D010455:Peptides