[The role of prenatal Coxsackievirus infection in the etiology of congenital heart defects in children].
Sixty-two children with congenital heart diseases and 100 normal children were examined, their age ranging from 5 days to 6 years. Indicators of intrauterine enterovirus infection risk were detected in 93.5% of children with congenital heart diseases and in just 21.9% of the controls. Coxsackie A and B viruses were detected by immunofluorescence in urinary sediment cells of 84.4% of children with congenital heart diseases vs. 7.7% of the controls. None of the 20 serotypes of Coxsackie A virus was detected at a predominant rate, as compared to others. Among the Coxsackie B serotypes, Coxsackie virus B3 was recovered particularly frequently. Etiologic relationship of congenital heart diseases to Coxsackie virus infection, and possible persistence of these viruses in children with congenital heart diseases are discussed.
Koro'lkova
E L
EL
Lozovskaia
L S
LS
Tadtaeva
L I
LI
Khellenov
E A
EA
D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications*; D004770:Enterovirus; D029822:Enterovirus B, Human; D005260:Female; D006330:Heart Defects, Congenital / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors
Znachenie antenata'lnoĭ Koksaki-virusnoĭ infektsii v étiologii vrozhdennykh porokov serdtsa u deteĭ.