title: Teicoplanin pharmacokinetics in patients undergoing continuous ambulatory peritoneal dialysis after intravenous and intraperitoneal dosing.
abstract: The pharmacokinetics of teicoplanin after single 6-mg/kg intravenous and intraperitoneal doses were studied in five noninfected patients undergoing continuous ambulatory peritoneal dialysis. Biological samples were assayed for teicoplanin content by a microbiological assay technique. Terminal disposition half-life (266.4 +/- 51.9 h [mean +/- standard error of the mean]) was prolonged and total body clearance (0.040 +/- 0.004 ml/min per kg) was reduced compared with values previously reported in subjects with normal renal function. The volume of distribution at steady state (1.15 +/- 0.19 liters/kg) was higher than values previously reported in subjects with normal renal function (0.56 to 0.72 liter/kg). Peritoneal dialysis clearance (0.007 +/- 0.001 ml/min per kg) accounted for only 16.1% of total body clearance. The absolute systemic bioavailability of teicoplanin after intraperitoneal administration was 81.5 +/- 10.7%.
authors.affiliation: Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota.
authors.forename: D R
authors.initials: DR
authors.lastname: Guay
authors.forename: W M
authors.initials: WM
authors.lastname: Awni
authors.forename: C E
authors.initials: CE
authors.lastname: Halstenson
authors.forename: M T
authors.initials: MT
authors.lastname: Kenny
authors.forename: W F
authors.initials: WF
authors.lastname: Keane
authors.forename: G R
authors.initials: GR
authors.lastname: Matzke
mesh_terms: D006020:Glycopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics; D006207:Half-Life; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D010531:Peritoneal Dialysis, Continuous Ambulatory; D017334:Teicoplanin
chemical_list: D006020:Glycopeptides; D017334:Teicoplanin