Effect of atrial natriuretic factor on blood-brain barrier permeability.
Recent studies have demonstrated receptors for atrial natriuretic factor on endothelium of intracerebral vessels. The physiological role of these receptors is not known. The present study was undertaken to determine whether atrial natriuretic factor has an effect on blood-brain barrier permeability to protein and ions using horseradish peroxidase and lanthanum as markers of permeability alterations. This study does not demonstrate a significant effect of atrial natriuretic factor on blood-brain barrier permeability mechanisms in steady states.
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Department of Pathology, Queen's University, Kingston, Ont., Canada.
Pang
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SC
D000818:Animals; D001160:Arterioles / Q000378:metabolism / Q000648:ultrastructure; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D066298:In Vitro Techniques; D007811:Lanthanum / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D007811:Lanthanum; D009320:Atrial Natriuretic Factor