Induction of a mixed ductal-squamous-islet cell carcinoma in a rat treated with a tobacco-specific carcinogen.
Treatment of rats with tobacco-specific nitrosamines resulted in the induction of pancreatic acinar cell and ductal cell neoplasms. One of these tumors had a mixed ductal-squamous-islet cell components, the electron microscopic and immunohistochemical patterns of which are described. This is the first report of such a pancreatic mixed cell neoplasm.
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PM
Eppley Institute, University of Nebraska Medical Center, Omaha 68105-1065.
Rivenson
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D007516:Adenoma, Islet Cell / Q000139:chemically induced* / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced* / Q000378:metabolism / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000378:metabolism / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009602:Nitrosamines / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000648:ultrastructure; D010947:Plants, Toxic; D051381:Rats; D011916:Rats, Inbred F344; D014026:Nicotiana / Q000032:analysis*
D009602:Nitrosamines