[Effect of prodigiozan on the antibody-dependent cytotoxicity of neutrophils in chronic myeloid leukemia].
Decreased levels of neutrophils, Fc- and C3-expressing receptors, oxygen-dependent metabolism as well as antibody-dependent cytotoxicity of these cells to target cells were identified in advanced chronic myeloid leukemia, particularly, in blast crisis. Treatment with cytostatic agents resulted in further decrease in said parameters. However, treatment with prodigiozan was followed by improvement in cell functioning.
Guseva
S A
SA
Tishchenko
L M
LM
D000276:Adjuvants, Immunologic; D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D011951:Receptors, Complement / Q000187:drug effects / Q000276:immunology; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D011354:Prodigiozan
Vliianie prodigiozana na antitelozavisimuiu tsitotoksichnost' neĭtrofilov pri khronicheskom mieloidnom leĭkoze.