title: Pharmacology and toxicology of azelaic acid.
abstract: The results of general pharmacological studies on metabolism, smooth muscles, renal function, cardiovascular and neurotropic effects do not contra-indicate the specific surface use of azelaic acid. From specific pharmacologic studies it is assumed that azelaic acid exerts its therapeutic effect in acne by an antimicrobial, probably bacteriostatic, effect on acne-relevant microorganisms such as Propioni bacerium acnes and, in addition, by a strong comedolytic effect. In numerous studies it has been demonstrated that azelaic acid is not toxic.
authors.affiliation: Research Laboratories of Schering AG, Berlin/Bergkamen.
authors.forename: M
authors.initials: M
authors.lastname: Töpert
authors.forename: P
authors.initials: P
authors.lastname: Rach
authors.forename: F
authors.initials: F
authors.lastname: Siegmund
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000818:Animals; D000890:Anti-Infective Agents; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D008055:Lipids / Q000096:biosynthesis; D012627:Sebaceous Glands / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D003998:Dicarboxylic Acids; D008055:Lipids; C010038:azelaic acid