Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells.
The steroidogenic action of ACTH-(11-24) was studied on isolated zona glomerulosa and zona fasciculata cells dispersed by collagenase. ACTH-(11-24) stimulated the corticosterone production of zona fasciculata cells and the aldosterone production of zona glomerulosa cells; in addition, it potentiated the effects of ACTH-(1-39) on both cell systems. It is suggested that the ACTH molecule contains more active sites for steroidogenesis than usually acknowledged, as has been found for lipolysis and behavior.
Szalay
K S
KS
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
De Wied
D
D
Stark
E
E
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D003345:Corticosterone / Q000096:biosynthesis; D003366:Cosyntropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D000305:Adrenal Cortex Hormones; D010446:Peptide Fragments; D003366:Cosyntropin; C034016:ACTH (11-24); D000324:Adrenocorticotropic Hormone; D003345:Corticosterone