Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain.
Serotonin lesioning studies were performed to determine the synaptic localization of the 5-HT1D receptor. Four days following p-chloroamphetamine (PCA; 5 mg/kg x 4) [3H]paroxetine-labeled uptake sites (a marker for 5-HT terminals) were reduced to 18% of control values in the cortex and 29% of control values in the striatum, while the number of 5-HT1D receptors remained unchanged. Fourteen days following PCA administration an up-regulation of cortical 5-HT1D receptors was observed. These findings indicate that 5-HT1D receptors are localized postsynaptically in the cortex and striatum, and that denervation of endogenous serotonergic input produces a compensatory up-regulation in the cortex.
Herrick-Davis
K
K
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Maisonneuve
I M
IM
Titeler
M
M
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017374:Paroxetine; D010880:Piperidines / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects / Q000378:metabolism*
D010880:Piperidines; D011985:Receptors, Serotonin; D017374:Paroxetine