title: Protein kinase C is involved in regulation of Ca2+ channels in plasmalemma of Nitella syncarpa.
abstract: Ca2+ current recordings have been made on Nitella syncarpa cells using the intracellular perfusion and the voltage-clamp technique. TPA (12-O-tetradecanoylphorbol-13-acetate), a substance capable of activating protein kinase C from plasmalemma of Nitella cells, modulates voltage-dependent Ca2+ channels. Polymixin B, inhibitor of protein kinase C, blocks the Nitella plasmalemma Ca2+ channels; the rate of channel blockage depends on the concentration and exposure time of the substance.
authors.affiliation: Institute of Biological Physics, Acad. Sci. USSR, Moscow Region.
authors.forename: O M
authors.initials: OM
authors.lastname: Zherelova
mesh_terms: D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity; D008564:Membrane Potentials; D018521:Plant Physiological Phenomena; D011112:Polymyxin B / Q000494:pharmacology; D011493:Protein Kinase C / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D015220:Calcium Channels; D011493:Protein Kinase C; D011112:Polymyxin B; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium