Radon progeny exposure and lung cancer risk in New Mexico U miners: a case-control study.
A case-control study was conducted to describe lung cancer risk in a cohort of New Mexico underground U miners. The subjects included 65 cases and 230 age-matched controls, most with exposures below 3.50 J h m-3 (1000 WLM). The risk for lung cancer was increased for all cumulative exposures to Rn progeny of 0.35 J h m-3 (100 WLM) or greater. The odds ratios were unchanged with control for cigarette smoking. With exclusion of subjects with exposures above 3.50 J h m-3 (1000 WLM), the estimated excess relative risk was 0.3% per mJ h m-3 (1.1% per WLM). The risk was greater for younger subjects and the data were consistent with a multiplicative interaction between cigarette smoking and exposure to Rn progeny.
Samet
J M
JM
Department of Medicine, University of New Mexico Medical Center, Albuquerque 87131.
Pathak
D R
DR
Morgan
M V
MV
Marbury
M C
MC
Key
C R
CR
Valdivia
A A
AA
D000328:Adult; D000368:Aged; D001729:Bismuth; D006801:Humans; D007854:Lead; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008906:Mining; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009516:New Mexico; D009784:Occupational Diseases / Q000209:etiology*; D011059:Polonium; D017687:Radon Daughters; D012307:Risk Factors; D014501:Uranium
D017687:Radon Daughters; D007854:Lead; D014501:Uranium; D011059:Polonium; D001729:Bismuth