[The central nervous system and neuroendocrine system in the regulation of the immune response].
There is at present a clear trend in the study of psychoneuroimmunoregulatory events. Different experimental models have demonstrated: a) the participation of stress, psychosocial factors and the central nervous system in the regulation of the immune response; b) an extensive innervation by the autonomic nervous system of the lymphatic organs; c) the presence of receptors for the neuroendocrine mediators in the mononuclear peripheral cells; d) the activity of neuropeptides, hormones and neurotransmitters in lymphocyte activation and function; e) the production of neuroendocrine substances by lymphocytes; f) the existence of feedback pathways in the immune system. In our laboratory we have contributed to these studies with the description of: a) the regulatory activity of different neuroendocrine substances on interferon-gamma production; b) the characterization of the immune regulation exercised by the muscarinic cholinergic system; c) the in vitro activity of the indoleamines, serotonin and melatonin on the immune response, and the production of these indoleamines by lymphocytes and monocytes, thus establishing a model of paracrine regulation.
Nahmod
V E
VE
Finkielman
S
S
Fernández-Castelo
S
S
Sterin-Princ
A
A
Polack
E
E
Rubinstein
E
E
Labeur
M
M
Arzt
E S
ES
D000305:Adrenal Cortex Hormones / Q000502:physiology; D000818:Animals; D000917:Antibody Formation; D002490:Central Nervous System / Q000502:physiology*; D004745:Enkephalins / Q000502:physiology; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D009479:Neuropeptides / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats
D000305:Adrenal Cortex Hormones; D004745:Enkephalins; D009479:Neuropeptides; D007371:Interferon-gamma
El sistema nervioso central y el sistema neuroendócrino en la regulación de la respuesta inmune.