[The products of class II histocompatibility complex (IC or IA+IE) restrict the interaction between specific T-suppressor and responder T-cells].
Spleen T cells of mice which were i.v. immunized with large dose of irradiated allogeneic lymphocytes inhibit donor alloantigen-activated DNA synthesis in mixed lymphocyte culture. To assure suppressor function, specific suppressor T cells (SSTC) both need to contact an antigen and ought to interact with responder T lymphocyte as well. Such an interaction is restricted in MHC class II genes: in IA + IE complex or in IC. IJ sub-region product present on the SSTC is not involved into the suppressor-responder interaction. By shielding of the SSTC markers with poly- and monoclonal antibodies to IC, IA and IE molecules, it is shown that two variants of suppression restriction are due to the respective SSTC sub-populations: only one of them bears ICd determinant, while both possess IAk and IEk antigens. The functions of SSTC sub-populations and their connection with immune response "interactional restriction" are discussed.
Zaĭtseva
M B
MB
Institute of Immunology, Academy of Medical Sciences of the USSR, Moscow.
Brondz
B D
BD
D000818:Animals; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D008211:Lymphocyte Cooperation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II
Produkty kompleksa gistosovmestimosti klassa II (IC ili IA+IE) restriktiruiut vzaimodeĭstvie mezhdu spetsifichnym T-supressorom i reagiruiushcheĭ T-kletkoĭ.