Alpha 1-adrenergic stimulation causes Mg2+ release from perfused rat liver.
The possibility that Mg2+ mobilization is stimulated in perfused liver by alpha 1-adrenergic agonists was studied by measuring Mg2+ release in response to 0.5 and 20 microM phenylephrine. During preperfusion exogenous Mg2+ was added to the medium to give 1.2 mM. 5 min before starting the addition of phenylephrine the infusion of exogenous Mg2+ was stopped. Mg2+ in the perfusate leaving the liver was measured by atomic absorption spectroscopy. Analysis of the Mg2+ decay curves with two exponential models indicated that phenylephrine caused dose-dependent Mg2+ release from perfused rat livers.
Jakob
A
A
Department of Biochemistry, Vesalianum, University of Basel, Switzerland.
Becker
J
J
Schöttli
G
G
Fritzsch
G
G
D000818:Animals; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D013054:Spectrophotometry, Atomic
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D006003:Glycogen; D008274:Magnesium; D005947:Glucose