title: Alterations in bovine neutrophil function during the periparturient period.
abstract: Neutrophils from 8 Holstein heifers were evaluated for function during the periparturient period. Random migration, ingestion of bacteria, superoxide anion production, native (nonenhanced) chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity by neutrophils were determined. Foremilk samples were evaluated for bacteria. Significant (P less than 0.05) increases in random migration of neutrophils, iodination, and chemiluminescence were evident 2 weeks before parturition and then decreased dramatically by the first week after parturition. These impairments of neutrophil function after parturition may be manifested as a severe cumulative deficit in the native defenses afforded by the neutrophil.
authors.affiliation: USDA, National Animal Disease Center, Ames, IA 50010.
authors.forename: M E
authors.initials: ME
authors.lastname: Kehrli
authors.forename: B J
authors.initials: BJ
authors.lastname: Nonnecke
authors.forename: J A
authors.initials: JA
authors.lastname: Roth
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002417:Cattle / Q000276:immunology*; D002465:Cell Movement; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D007455:Iodine / Q000378:metabolism; D007743:Labor, Obstetric / Q000097:blood / Q000276:immunology*; D008163:Luminescent Measurements; D008321:Mammary Glands, Animal / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D010587:Phagocytosis; D049590:Postpartum Period / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors
chemical_list: D013481:Superoxides; D007455:Iodine