Serotonin function in panic disorder: effect of 1-5-hydroxytryptophan in patients and controls.
The responsivity of the serotonergic system to 5-hydroxytryptophan (5-HTP) administration was investigated in seven patients with panic disorder and seven healthy controls. Using cortisol and beta-endorphin as hormonal probes, no evidence was obtained for a dysfunction of the serotonin system in patients. Behaviorally, controls responded differently from patients, in that controls seemed to be more sensitive to 5-HTP. None of the subjects reported an increase in anxiety.
Westenberg
H G
HG
Department of Biological Psychiatry, Academic Hospital Utrecht, The Netherlands.
den Boer
J A
JA
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000328:Adult; D005239:Fear / Q000502:physiology*; D005260:Female; D006207:Half-Life; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D010200:Panic / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D001615:beta-Endorphin / Q000097:blood
D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D001615:beta-Endorphin; D006916:5-Hydroxytryptophan; D009638:Norepinephrine