title: Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.
abstract: Brainstem and cortical Lewy bodies in diffuse Lewy body disease show intense immunoreactivity to antibodies against ubiquitin. Quantitative studies show that the novel neuropathological technique of anti-ubiquitin immunocytochemistry is more than twice as sensitive as conventional haematoxylin and eosin stains in detecting cortical Lewy bodies. Anti-ubiquitin immunocytochemistry should be regarded as the method of choice for the diagnosis and quantification of diffuse Lewy body disease.
authors.affiliation: Department of Neurology, Queen's Medical Centre, Nottingham, UK.
authors.forename: G
authors.initials: G
authors.lastname: Lennox
authors.forename: J
authors.initials: J
authors.lastname: Lowe
authors.forename: K
authors.initials: K
authors.lastname: Morrell
authors.forename: M
authors.initials: M
authors.lastname: Landon
authors.forename: R J
authors.initials: RJ
authors.lastname: Mayer
mesh_terms: D000906:Antibodies; D001933:Brain Stem / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000648:ultrastructure*; D010300:Parkinson Disease / Q000473:pathology*; D014452:Ubiquitins / Q000276:immunology*
chemical_list: D000906:Antibodies; D014452:Ubiquitins