[Experimental verification of the favorable activity of synthetic corticostimulin on brain edema induced by ischemia in rats].
The anti-oedematous effect of tetracosactide (Synacthene Immediate) was studied on a rat brain transient global ischaemia model. Brain oedema was evaluated by proton nuclear magnetic resonance, with measurement of T1 and T2 relaxation times in the cortex and white matter. The effective kinetic dose of tetracosactide was 0.4 mg/kg, and a comparison of the results obtained with those observed after treatment with dexamethasone 13 mg/kg confirmed that both drugs may be regarded as potent anti-oedematous agents, but there was nothing in this study to suggest that the mechanism of action of tetracosactide was different from that of corticosteroids.
Gandon
J M
JM
Laboratoire de Résonance magnétique nucléaire, Faculté de Médecine, Rennes.
Bagot
H
H
Bentue-Ferrer
D
D
Allain
H
H
de Certaines
J D
JD
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D003366:Cosyntropin / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D002546:Ischemic Attack, Transient / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003366:Cosyntropin; D003907:Dexamethasone
Vérification expérimentale de l'action bénéfique de la corticostimuline de synthèse sur l'oedème cérébral induit par l'ischémie chez le rat.