title: Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet.
abstract: We describe a synergistic effect of combinations of foscarnet and 3'-azido-3'-deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3'-azido-3'-deoxythymidine triphosphate against human immunodeficiency virus type 1 reverse transcriptase, and a low toxicity in cell culture of combinations of the two drugs.
authors.affiliation: Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Koshida
authors.forename: L
authors.initials: L
authors.lastname: Vrang
authors.forename: G
authors.initials: G
authors.lastname: Gilljam
authors.forename: J
authors.initials: J
authors.lastname: Harmenberg
authors.forename: B
authors.initials: B
authors.lastname: Oberg
authors.forename: B
authors.initials: B
authors.lastname: Wahren
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D017245:Foscarnet; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D015215:Zidovudine / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000998:Antiviral Agents; D009943:Organophosphorus Compounds; D017245:Foscarnet; D015215:Zidovudine; D010746:Phosphonoacetic Acid