[The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure].
The influence of valproic acid on sleep structure and alcohol motivation was studied in pretyped rats prior and following REM sleep deprivation. During EEG recording of wake-sleep cycle valporoic acid was shown to produce hypnotic action dependent on drug dosage in high active and low active animals. There was also shown that following REM sleep deprivation low active animals significantly reduced ethanol consumption under valproic acid influence. It seems likely from the results obtained that valproic acid could be used as hypnotic and antialcoholic drug.
Mdzinarishvili
A L
AL
Molodavkin
G A
GA
Voronina
T A
TA
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D004569:Electroencephalography; D007206:Individuality; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*; D014635:Valproic Acid / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D014635:Valproic Acid
Vliianie val'proevoĭ kisloty na strukturu sna i potreblenie étanola u krys s razlichnymi tipami individual'noĭ reaktivnosti do i posle stressornogo vozdeĭstviia.