Activity of the unstimulated renin-angiotensin-aldosterone system in type 1 diabetic patients with and without proteinuria.
There have been conflicting reports of the activity of the renin-angiotensin-aldosterone system in diabetes. We studied the activity of the unstimulated renin-angiotensin-aldosterone system in 73 consecutive Type 1 diabetic patients with varying degrees of albuminuria. Patients with elevated albumin excretion rates had elevated median plasma renin activity (macroalbuminuric 2.2, range 0.5-8.2, p less than 0.05; microalbuminuric 2.3, 0.7-7.1, p less than 0.001; vs normoalbuminuric 1.0, 0.2-4.5 nmol l-1 h-1) and higher systolic blood pressure (macroalbuminuric 141 +/- 27 vs normoalbuminuric 116 +/- 13 mmHg, mean +/- SD, p less than 0.01) compared with those with normal albumin excretion rates. Aldosterone secretion and function were normal in all patients studied.
O'Donnell
M J
MJ
Department of Medicine, University of Birmingham, UK.
Lawson
N
N
Barnett
A H
AH
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D011188:Potassium / Q000097:blood / Q000652:urine; D011507:Proteinuria; D012084:Renin-Angiotensin System; D012964:Sodium / Q000097:blood / Q000652:urine
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D011188:Potassium; D012964:Sodium