[Use of difenin in the treatment of constitutionally tall girls].
Thirteen constitutionally tall girls marked by certain retardation of sexual development, confirmed by clinical, instrumental and laboratory studies were examined. The girls' age ranged within 11 to 15 years. The examinations were performed before and during phenytoin treatment. The data obtained indicate that during phenytoin treatment, increment of the body length decreased to 1-3 cm over one year; skeletal maturation was found to be accelerated by 2-5 years. In 8 patients, menstruations occurred by themselves and in 5, the menstrual cycle returned to normal. The rise of the content of follicle-stimulating and somatotropic hormones as well as of estradiol together with a tendency towards cortisol content lowering were recorded. Based on the studies performed it may be ascertained that the use of phenytoin inhibits the growth rate, accelerates the closing of the zones of bone growth, promotes normalization of menstrual function, and expedites menarche.
Bogdanova
E A
EA
Afonina
L I
LI
Varlamova
T M
TM
Gasan-Dzhalalova
S A
SA
D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D001846:Bone Development / Q000187:drug effects; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008572:Menarche / Q000187:drug effects; D010672:Phenytoin / Q000627:therapeutic use*
D004958:Estradiol; D010672:Phenytoin; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D006854:Hydrocortisone
Primenenie difenina v lechenii konstitutsional'noĭ vysokoroslosti u devochek.