Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age.
Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).
Ingham
C A
CA
Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, U.K.
Hood
S H
SH
Arbuthnott
G W
GW
D000375:Aging / Q000502:physiology*; D000818:Animals; D003342:Corpus Striatum / Q000254:growth & development* / Q000648:ultrastructure; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D006892:Hydroxydopamines; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D016627:Oxidopamine