title: [Tissue-type plasminogen activator--biochemistry, physiology and clinical use].
abstract: Tissue plasminogen activator (t-PA) is the main physiological activator of the fibrinolysis process present in nearly all organs, tissues and secretions. Its most important function is dissolving of intervascular fibrin deposits. T-PA is synthesized and secreted by the endothelium of blood vessels in response to various stimuli. Its enzymatic activity in plasma is controlled by rapidly acting inhibitors. Reduced generation of t-PA activity may be the cause of thrombotic changes in the vascular system. Studies are conducted presently on the use of t-PA in thrombolytic treatment.
authors.forename: J
authors.initials: J
authors.lastname: Gmiński
authors.forename: A
authors.initials: A
authors.lastname: Flak
mesh_terms: D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000172:deficiency / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D010959:Tissue Plasminogen Activator
vernacular_title: Tkankowy aktywator plazminogenu--biochemia, fizjologia i zastosowanie kliniczne.