Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms.
A new promoter located within E6 was mapped in human papillomavirus type 6b (HPV6b)- and HPV11-containing benign genital condylomata (genital warts). The RNA transcribed from this promoter represented the major RNA species colinear with open reading frames E6 and E7 and can encode the E7 protein. No equivalent promoter was active in HPV16-containing cancers and cancer-derived cell lines. In those, the major transcripts contained one of two different introns within E6 and the RNAs could encode two different E6 proteins and E7.
Smotkin
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Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles 90024.
Prokoph
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Wettstein
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D000595:Amino Acid Sequence; D001483:Base Sequence; D002277:Carcinoma / Q000382:microbiology; D003218:Condylomata Acuminata / Q000382:microbiology; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity; D011401:Promoter Regions, Genetic; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic; D002583:Uterine Cervical Neoplasms / Q000382:microbiology; D014764:Viral Proteins / Q000235:genetics*
D004268:DNA-Binding Proteins; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D012333:RNA, Messenger; D014764:Viral Proteins