title: Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man.
abstract: Nocturnal plasma melatonin concentrations were reduced following administration of the alpha 1 adrenoceptor antagonist, prazosin (2 mg orally at 1900h), to 10 normal men. These data indicate that alpha 1 adrenoceptors are involved in the physiological control of melatonin secretion in man.
authors.affiliation: Institute of Psychiatry, De Crespigny Park, London, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Palazidou
authors.forename: C
authors.initials: C
authors.lastname: Franey
authors.forename: J
authors.initials: J
authors.lastname: Arendt
authors.forename: S
authors.initials: S
authors.lastname: Stahl
authors.forename: S
authors.initials: S
authors.lastname: Checkley
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D010870:Pineal Gland / Q000187:drug effects / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
chemical_list: D011941:Receptors, Adrenergic; D008550:Melatonin; D011224:Prazosin