title: Effect of age on the modification of brain polyunsaturated fatty acids and enzyme activities by fish oil diet in rats.
abstract: To determine the effect of age on the modification of brain lipids and functions by fish oil and lard diets, the polyunsaturated fatty acids, phospholipid states and enzyme activities of intracellular organelles in young and aged rats fed these diets were analyzed. The concentration of arachidonic acid (20:4) and docosahexaenoic acid (22:6) tended to decrease with increasing age. The UV absorption of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) also decreased. An increasing effect of the sardine oil diet on brain 22:6 concentration in aged rats was slightly greater than that in young rats. However, the modification of 20:4 concentration in aged rats was similar to that in young rats. Significant increases in the UV absorption of PE and PC of aged rats fed the fish oil diet were observed. The lactate dehydrogenase (LDH) activities of aged rats fed the sardine oil diet increased significantly, whereas the activities of aged rats fed the lard diet decreased. These results suggest that fish oil may be able to regulate the brain lipid composition and LDH activity in aged rats.
authors.affiliation: National Food Research Institute, Ibaraki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Hayakawa
authors.forename: S
authors.initials: S
authors.lastname: Wada
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects*; D004281:Docosahexaenoic Acids / Q000032:analysis; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005395:Fish Oils / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010743:Phospholipids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D007770:L-Lactate Dehydrogenase; D008995:Monoamine Oxidase; D000135:Acid Phosphatase