[The effect of nitrates and miskleron on the prostacyclin-thromboxane ratio and on the functional activity of the thrombocytes in stenocardia patients].
Results of treatment of patients with stable stenocardia by means of nitrates indicate that the antianginal effect was parallelled by an increase of the sensitivity of thrombocytes to prostacyclin and level of the plasma metabolite prostacyclin. The hypolipidemic effect of miscleron therapy is accompanied in patients with ischemic heart disease by reduction of the aggregation properties of thrombocytes and level of the metabolite thromboxane A2 in the plasma. The rationality of combined treatment with miscleron and nitrates is substantiated from the position of aimed effect on important links of atherogenesis and ischemic heart disease, namely functional properties of thrombocytes, prostacyclin-thromboxane ratio and level of blood lipids.
Volkov
V I
VI
Ladnyĭ
A I
AI
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002994:Clofibrate / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D011464:Epoprostenol / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use*; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013931:Thromboxanes / Q000097:blood*
D009566:Nitrates; D010975:Platelet Aggregation Inhibitors; D013931:Thromboxanes; D011464:Epoprostenol; D002994:Clofibrate
Vliianie nitratov i misklerona na prostotsiklin-tromboksanovoe sootnoshenie i funktsional'nuiu aktivnost' trombotsitov u bol'nykh stenokardieĭ.