Involvement of calcium ions in the development of ischemia and reperfusion injury of the myocardium.
The hypothesis that abnormal rise in [Ca2+]i is a trigger mechanism of irreversible injury in an ischemic and reperfused myocardium was proposed long ago. It is well established that such a rise appears in reperfused myocardium. Only recently direct experimental evidence was provided that the rise in [Ca2+]i also appears early during ischemia and that it precedes manifestations of irreversible injury. However, until the Ca dependent mechanism triggering the process of myocardial injury is identified, the Ca hypothesis cannot be fully accepted.
Beresewicz
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Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warsaw, Poland.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002118:Calcium