[Metabolism of B group vitamins in rats, receiving rations with various amounts of protein and amino acids under conditions of chronic aniline poisoning].
The influence of the isocalorific rations with decreased (10%) or increased (32%) protein content, and addition of cystine, methionine and glutamic acid (100 mg/kg) on metabolism of vitamins B2, B6 and PP was studied in rats under conditions of experimental chronic aniline intoxication. Increased protein amount in the diet and addition of amino acids sharply raise vitamin B6 requirement; vitamin B2 requirement grows with the increase of protein fraction and methionine and glutamic acid addition. Providing with vitamin PP under these conditions rises. Chronic aniline intoxication negatively influences the vitamin status of the test animals. Providing with vitamin B6 is most sharply decreased. Glutamic acid shows "saving" influence with respect to vitamin B2. The effect of chronic aniline intoxication on providing with vitamin PP is most manifested in the redistribution of oxidized and reduced nicotine amide coenzymes in the liver in the direction of a relative growth of reduced NAD and NADP concentrations.
Perevalov
A Ia
AIa
Tsareva
O A
OA
D000596:Amino Acids / Q000008:administration & dosage*; D000814:Aniline Compounds / Q000506:poisoning*; D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D008099:Liver / Q000201:enzymology; D008297:Male; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D051381:Rats; D014803:Vitamin B Complex / Q000378:metabolism*
D000596:Amino Acids; D000814:Aniline Compounds; D004044:Dietary Proteins; D009243:NAD; D014803:Vitamin B Complex; D009536:Niacinamide; D009249:NADP; C023650:aniline
Metabolizm vitaminov gruppy B u krys, poluchavshikh ratsiony s razlichnym kolichestvom belka i aminokislot v usloviiakh khronicheskoĭ anilinovoĭ intoksikatsii.