[Monitoring of renal grafts. Value of the determination of serum neopterin and neopterin versus creatinine ratio].
In a longitudinal study, 53 renal allograft recipients were investigated for changes in serum creatinine and neopterin levels and in the neopterin/creatinine (N/C) ratio which makes it possible to disregard the glomerular filtration level. The patients were divided into 5 groups according to their clinical situation: stability, acute renal failure due to acute tubular necrosis, acute graft rejection, bacterial or viral infection and cyclosporin overdosage. Only N/C discriminated between these situations, being normal (less than 200.10(-6) in groups 1 and 2, significantly elevated in groups 3 and 4 and low in group 5. The highest N/C value was observed in patients with primary cytomegalovirus infection. It is concluded that the N/C ratio is a good biochemical parameter to be used in the follow-up of renal allograft recipients.
Hacini
J
J
Service de Néphrologie, CHU de Saint-Etienne, Hôpital Nord, Saint-Priest-en-Jarez.
Berthoux
P
P
Guerin
C
C
Charrere
G
G
Ville
G
G
Berthoux
F C
FC
D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D011184:Postoperative Period; D011446:Prospective Studies
D001708:Biopterins; D019798:Neopterin; D003404:Creatinine
Surveillance des greffes rénales. Intérêt du dosage de la néoptérine sérique et du rapport sérique néoptérine sur créatinine.