Alterations in transformation efficiency by the ADPRT-inhibitor 3-aminobenzamide are oncogene specific.
The ADPRT inhibitor 3-aminobenzamide inhibits transformation of NIH 3T3 cells by the ras, v-src, v-mos and v-raf oncogenes. No effect was observed on transformation by v-fos while the transforming efficiency of SV40 DNA was increased approximately two-fold. The effect on the transformation by the ras gene occurs between days 3 and 7 of the transfection.
Diamond
A M
AM
Department of Radiation and Cellular Oncology, University of Chicago, IL 60637.
Der
C J
CJ
Schwartz
J L
JL
D001549:Benzamides / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral / Q000187:drug effects; D009857:Oncogenes; D013539:Simian virus 40
D001549:Benzamides; C025160:3-aminobenzamide