title: [A combination of sufentanil and 0.25% bupivacaine administered epidurally for obstetrical analgesia. Comparison with fentanyl and placebo].
abstract: The study reported was designed to determine whether 15 micrograms sufentanil would provide analgesia comparable in duration and quality with that given by 75 micrograms fentanyl, when associated with plain 0.25% bupivacaine for extradural analgesia for labour. Patients (n = 124) in labour and at full term were randomly divided into 3 groups. Group 1 (n = 41) were given 12 ml of 0.25% plain bupivacaine with saline, group 2 (n = 41) 12 ml of 0.25% plain bupivacaine with 75 micrograms fentanyl and group 3 (n = 42) 12 ml of 0.25% plain bupivacaine with 15 micrograms sufentanil. 11 cases were excluded from the study (8 Caesarean sections, 3 technical failures). The duration of analgesia obtained with the two opioids was similar (group 2: 126.7 +/- 6.5 min, p less than 0.01; group 3: 114.9 +/- 5.8 min, p less than 0.01; group 1: 93.6 +/- 5.4 min) as well as the quality of pain relief. There were no differences between the three groups with regard to Apgar scores. The only side-effect seen with sufentanil and fentanyl was pruritus (group 2: 21.9%, p less than 0.05; group 3: 21.4%, p less than 0.05; group 1: 2.4%). These results showed that 15 micrograms sufentanil could replace 75 micrograms fentanyl for extradural pain relief of labour with plain 0.25% bupivacaine. However, the use of opioids with local anaesthetics would seem to be of interest only if labour is likely to be prolonged.
authors.affiliation: Département d'Anesthésie-Réanimation Chirurgicale, Groupe Hospitalier Cochin-Maternités, Paris.
authors.forename: J C
authors.initials: JC
authors.lastname: Jorrot
authors.forename: J D
authors.initials: JD
authors.lastname: Lirzin
authors.forename: P
authors.initials: P
authors.lastname: Dailland
authors.forename: P
authors.initials: P
authors.lastname: Jacquinot
authors.forename: C
authors.initials: C
authors.lastname: Conseiller
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods*; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000379:methods*; D001034:Apgar Score; D002045:Bupivacaine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D010919:Placebos; D011247:Pregnancy; D011446:Prospective Studies; D011537:Pruritus / Q000139:chemically induced; D017409:Sufentanil
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D010919:Placebos; D017409:Sufentanil; D005283:Fentanyl; D002045:Bupivacaine
vernacular_title: Association sufentanil-bupivacaïne à 0.25% par voie péridurale pour l'analgésie obstétricale. Comparaison avec le fentanyl et un placebo.