[Effect on immunological response of host by mitomycin C adsorbed into activated carbon particles (MMC-CH) in mice].
Mitomycin C adsorbed onto activated carbon particles (MMC-CH) has been administered intraperitoneally for C57BL/6 mice. The weight of the spleen and thymus of the mice given MMC-CH was decreased lesser than those of the mice given mitomycin C aqueous solution (MMC-AQ). The number of peritoneal exudate cells (PEC) in the mice given MMC-AQ was decreased remarkably on 1st day after MMC-AQ administration and recovered within normal range on the 7th day. On the other hand, the number of PEC in the mice given MMC-CH was increased remarkably on the 1st day and then gradually decreased to normal range on the 7th day. Reactivity of spleen cells by Con A was inhibited in the spleen cells from the mice given MMC-AQ more than those from the mice given MMC-CH. Fifth percent lethal dose was 8.0mg/kg in the mice given MMC-AQ, and 18.2mg/kg in the mice given MMC-CH.
Iwamoto
A
A
1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Sakita
M
M
Hata
K
K
Hagiwara
A
A
Takahashi
T
T
D000042:Absorption; D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D002244:Carbon; D002452:Cell Count / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D014867:Water
D008937:Mitomycins; D014867:Water; D016685:Mitomycin; D002244:Carbon