Effects of dibutyryl cyclic AMP on hemodynamics and plasma catecholamine concentrations during ammonium chloride-induced metabolic acidosis in anesthetized dogs.
We investigated, using anesthetized dogs, the effect of dibutyryl cyclic AMP (db-cAMP), a derivative of cyclic AMP (cAMP), on cardiovascular variants and plasma catecholamines during metabolic acidosis. These effects were also compared with those of dopamine. The db-cAMP and dopamine were infused at 200 and 20 micrograms/kg.min, respectively. Metabolic acidosis (pH 7.00, PaCO2 40 torr) was induced by the iv infusion of 1-M ammonium chloride solution (NH4Cl). In the normal acid-base state, both db-cAMP and dopamine significantly increased cardiac output and decreased systemic vascular resistance (SVR). During metabolic acidosis, db-cAMP increased cardiac output by 69 +/- 14% and decreased SVR by 36 +/- 2%, while dopamine did not produce changes in cardiac output and increased SVR. Dopamine caused an elevation of epinephrine and norepinephrine in the normal acid-base state, but db-cAMP did not. During metabolic acidosis, dopamine significantly increased the plasma concentration of epinephrine and norepinephrine, while db-cAMP significantly decreased epinephrine concentration. These results suggest that db-cAMP may have a more beneficial effect on hemodynamics compared with dopamine when therapeutic support is needed during circulatory insufficiency with severe metabolic acidosis.
Taneyama
C
C
Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan.
Satoh
T
T
Nagayama
T
T
Sakio
H
H
Okuda
C
C
D000138:Acidosis / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D000643:Ammonium Chloride; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000097:blood*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
D002395:Catecholamines; D000643:Ammonium Chloride; D002245:Carbon Dioxide; D003994:Bucladesine; D010100:Oxygen; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine