title: Effects of the NMDA receptor antagonist MK-801 against amygdaloid-kindled seizures in the rat.
abstract: The effects of acute and subchronic administration of the noncompetitive NMDA receptor antagonist MK-801 on the duration and severity of amygdaloid-kindled seizures in rats were determined to evaluate its anticonvulsant activity. Both the highest acute (1000 micrograms/kg) and subchronic regimens (2 x 300 micrograms/kg, 7 days) produced significant reductions in the seizure stage and afterdischarge duration. Although ataxia may have affected the seizure stage, MK-801 attenuated the primary afterdischarge suggesting anticonvulsant effects in the fully amygdaloid-kindled rat. Since tolerance develops to the behavioral effects of MK-801, other noncompetitive NMDA antagonists related to MK-801 seem to warrant evaluation as anticonvulsants.
authors.affiliation: University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: N A
authors.initials: NA
authors.lastname: Young
authors.forename: S J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: F J
authors.initials: FJ
authors.lastname: Vajda
authors.forename: P M
authors.initials: PM
authors.lastname: Beart
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D004305:Dose-Response Relationship, Drug; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012640:Seizures / Q000503:physiopathology*
chemical_list: D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate