title: Pathogenesis of type I (insulin-dependent) diabetes: possible mechanisms of autoimmune damage.
abstract: By definition, autoimmunity is a circumvention of self-tolerance. Considering the complex network of control mechanisms which initiate and regulate immune responses to foreign agents and maintain the natural state of self-tolerance, autoimmunity may result from a weakening of this delicate equilibrium at various levels. Several hypotheses have therefore been put forward to explain the 'active' immunization process against self-constituents which are normally tolerated.
authors.forename: G F
authors.initials: GF
authors.lastname: Bottazzo
authors.forename: E
authors.initials: E
authors.lastname: Bosi
authors.forename: E
authors.initials: E
authors.lastname: Bonifacio
authors.forename: R
authors.initials: R
authors.lastname: Mirakian
authors.forename: I
authors.initials: I
authors.lastname: Todd
authors.forename: R
authors.initials: R
authors.lastname: Pujol-Borrell
mesh_terms: D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D007130:Immunoglobulin Idiotypes