title: [Assessment of the effectiveness of Androcur in the treatment of precocious puberty].
abstract: The data are provided on the continuous use of Androcur in the treatment of genuine precocious puberty in children. The drug produced a beneficial effect in 100% of cases in respect to suppression of the secondary sexual characters, menstrual function in girls, and behavior normalization in boys. During treatment, the improvement of the growth prognosis was negligible. Stabilization of the processes of osseous maturation requires administration of the maximal drug doses, which may suppress glucocorticoid function of the adrenals. This fact should be taken into account during treatment, particularly on its discontinuation. The treatment should be discontinued according to the schedule similar to that applied in glucocorticoid discontinuation.
authors.forename: T V
authors.initials: TV
authors.lastname: Semicheva
mesh_terms: D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003534:Cyproterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017373:Cyproterone Acetate; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011629:Puberty, Precocious / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000726:Androgen Antagonists; D017373:Cyproterone Acetate; D003534:Cyproterone
vernacular_title: Otsenka éffektivnosti primeneniia Androkura pri lechenii prezhdevremennogo polovogo razvitiia.