title: Plasma amino acids in patients with senile dementia and in subjects with Down's syndrome at an age vulnerable to Alzheimer changes.
abstract: Plasma concentration of tryptophan, tyrosine, leucine and thiamine were reduced in senile dementia of Alzheimer type. In Down's syndrome, where Alzheimer-type histology appears consistently at an early age, there was a definite type of abnormality, raised concentrations of isoleucine, leucine, phenylalanine and cystine. Because of the competition between amino acids for transfer into the brain, either or both of these types of change could lie in the aetiological chain underlying the development of Alzheimer pathology. Alternatively, these patterns could reflect the requirements of aberrant central/peripheral protein turnover.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Whitchurch Hospital, Cardiff, Wales.
authors.forename: S E
authors.initials: SE
authors.lastname: Watkins
authors.forename: D E
authors.initials: DE
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Clifford
authors.forename: S F
authors.initials: SF
authors.lastname: Tidmarsh
authors.forename: A E
authors.initials: AE
authors.lastname: Sweeney
authors.forename: E
authors.initials: E
authors.lastname: Ah-Sing
authors.forename: J W
authors.initials: JW
authors.lastname: Dickerson
authors.forename: V A
authors.initials: VA
authors.lastname: Cowie
authors.forename: D M
authors.initials: DM
authors.lastname: Shaw
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000097:blood*; D000596:Amino Acids / Q000097:blood*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D000596:Amino Acids