title: Lymphocyte subsets in the cerebrospinal fluid in active multiple sclerosis.
abstract: We studied the relative number of lymphocyte subsets in the cerebrospinal fluid (CSF) of patients with active multiple sclerosis. The cells were double-labeled with monoclonal antibodies and were studied using a fluorescence-activated cell analyzer. The number of Leu2+Leu15+ cells and Leu3+Leu18+ cells was markedly reduced in the CSF but not in the peripheral blood of the patients. The number of Leu3+Leu18+ cells was reduced also in the CSF of control patients (patients with other inflammatory or infectious neurological diseases).
authors.affiliation: Department of Neurology, University of Turku, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Salonen
authors.forename: J
authors.initials: J
authors.lastname: Ilonen
authors.forename: H
authors.initials: H
authors.lastname: Jägerroos
authors.forename: H
authors.initials: H
authors.lastname: Syrjälä
authors.forename: T
authors.initials: T
authors.lastname: Nurmi
authors.forename: M
authors.initials: M
authors.lastname: Reunanen
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*