title: Heparin cofactor II in adults and infants with thrombosis and DIC.
abstract: Heparin cofactor II (HC II) was measured by a chromogenic activity assay in normal preterm infants (gestational age, 28-36 weeks; n = 17; 29% +/- 11.5 [mean +/- 1 SD], range 11-51), normal full-term infants (n = 18; 49% +/- 6.6 [mean +/- 1 SD], range 36-58), and normal adults (n = 38; 101% +/- 14 [mean +/- 1 SD], range 73-130). Normal children attained adult levels at approximately 5 to 7 months of age. The lower values in preterm and term infants most likely reflect immature liver function. Neither adults and children with a history of thrombosis with prior negative evaluation (n = 74), patients with documented protein C and protein S deficiency (n = 4), nor sick infants without evidence of consumptive coagulopathy (n = 15) had significantly lower levels of HC II activity. Infants with disseminated intravascular coagulation (n = 2) had strikingly lower levels of HC II activity.
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.
authors.forename: A
authors.initials: A
authors.lastname: Chuansumrit
authors.forename: M J
authors.initials: MJ
authors.lastname: Manco-Johnson
authors.forename: W E
authors.initials: WE
authors.lastname: Hathaway
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D006023:Glycoproteins / Q000097:blood* / Q000172:deficiency; D015844:Heparin Cofactor II; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020151:Protein C Deficiency; D017293:Protein S; D012016:Reference Values; D013927:Thrombosis / Q000097:blood*
chemical_list: D006023:Glycoproteins; D017293:Protein S; D015844:Heparin Cofactor II