[The effect of prostaglandin E2 on transport processes in the hepatocytes during parenteral feeding against a background of protein starvation].
Experiments were conducted in 50 white rats (180-220 g bw). Activities of total, Mg2-dependent, Na+, K+ and Ca2(+)-ATPases and sodium transport in hepatocytes of the animals under normal conditions and in the presence of protein deficiency were studied in five test series. Protein deficiency was found to be attended by a significant rise in the activity of the enzymes studied, and by disorders in sodium transport in hepatocytes. Administration of casein hydrolysate, in the presence of protein deficiency in the animals, induced a tendency to normalization of the processes studied. Casein hydrolysate used simultaneously with PGE2 produced more pronounced changes in ATP activity and sodium transport in hepatocytes. Basing on the results of the investigations it has been suggested that casein hydrolysate effect can be intensified by PGE2, thus it can be widely used in clinical practice.
Glants
R M
RM
Liubinets
L A
LA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D015232:Dinoprostone / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010288:Parenteral Nutrition; D011488:Protein Deficiency / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D000251:Adenosine Triphosphatases; D015232:Dinoprostone
Vliianie prostaglandina E2 na transportnye protsessy v gepatotsitakh pri parenteral'nom pitanii na fone belkovogo golodaniia.