title: Limited small cell lung cancer treated by combined radiotherapy and chemotherapy: evaluation of a grading system of lung fibrosis.
abstract: A grading system of radiological fibrosis was defined and applied by four observers for the reading of 218 posterior-anterior chest X-rays of 78 patients. These patients with limited small cell lung cancer were treated from May 1980 to July 1983 in two consecutive alternating radiotherapy-chemotherapy schedules. Chest X-rays performed at each 6-month interval were read by each observer. A second reading was performed the day after. The analysis of results showed that in spite of some systematic variations in intra- and inter-observations, the proposed grading system had a good reproducibility. The radiological lung fibrosis score progressed between 6 and 12 months but was stable after one year of follow-up. There was no difference in the score of lung fibrosis between the two protocols which delivered a total dose of 45 and 55 Gy to the mediastinum. There was no significant correlation between the radiological changes and clinical symptoms.
authors.affiliation: Institut Gustave-Roussy, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Arriagada
authors.forename: J C
authors.initials: JC
authors.lastname: de Guevara
authors.forename: H
authors.initials: H
authors.lastname: Mouriesse
authors.forename: C
authors.initials: C
authors.lastname: Hanzen
authors.forename: D
authors.initials: D
authors.lastname: Couanet
authors.forename: P
authors.initials: P
authors.lastname: Ruffie
authors.forename: P
authors.initials: P
authors.lastname: Baldeyrou
authors.forename: J
authors.initials: J
authors.lastname: Dewar
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: M
authors.initials: M
authors.lastname: Martin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D011859:Radiography; D011878:Radiotherapy / Q000379:methods*