[Disturbance of immunogenesis in patients with systemic lupus erythematosus].
Using a modified model, 16 patients with systemic lupus erythematosus were examined for the activity of nonspecific Con A-induced suppressors with the aid of different test systems. The suppressors of both patients and donors were employed. The proliferation of the test culture lymphocytes appeared to be activated. The immunogenetic abnormalities indicated seem likely to be related to extreme activity of the countersuppressor cells blocking the function of the suppressors, correlating with the clinical picture of the disease.
Adamian
N V
NV
Solov'ev
S K
SK
Gambarov
S S
SS
Alekseev
L P
LP
D000293:Adolescent; D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation; D008937:Mitomycins / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D008937:Mitomycins; D003208:Concanavalin A
Narushenie immunogeneza u bol'nykh sistemnoĭ krasnoĭ volchankoĭ.