title: [Requirement of an "ideal" drug for prevention of space motion sickness].
abstract: The range of effects and mechanisms of action of drugs that are promising in terms of the development of a potent and low toxicity drug to prevent space motion sickness was identified. The use of anticonvulsive and adaptogenic drugs as a prophylactic measure of the syndrome was theoretically confirmed. In human studies these drugs were shown to exert a noticeable effect on statokinetic stability and mental performance. Possible mechanisms of anti-motion++ action of the drugs are described. Requirements for an ideal drug to prevent space motion sickness are formulated.
authors.forename: N N
authors.initials: NN
authors.lastname: Karkishchenko
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000337:Aerospace Medicine; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000209:etiology / Q000517:prevention & control*; D009963:Orotic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D010672:Phenytoin / Q000008:administration & dosage* / Q000494:pharmacology; D010919:Placebos; D012601:Scopolamine / Q000008:administration & dosage* / Q000494:pharmacology; D013026:Space Flight; D014635:Valproic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D014722:Vestibule, Labyrinth / Q000187:drug effects*
chemical_list: D010919:Placebos; D000082:Acetaminophen; D014635:Valproic Acid; D010672:Phenytoin; D009963:Orotic Acid; D012601:Scopolamine
vernacular_title: O trebovaniiakh k "idea'lnomu" lekarstvennomu sredstvu profilaktiki kosmicheskoĭ bolezni dvizheniia.