The Rh-negative donor.
By typing fully for Rh, donor samples found to be D-negative but C-positive and/or E-positive on the Kontron Groupamatic G2000, the incidence of Ccddee (r'r) was found to be 0.44%, ccddEe (r"r) 0.50% and Du 0.30%. A total of 15,000 samples typed on the Groupamatic as D-, C- and E-negative were tested by an antiglobulin technique for Du, but none was found to be positive. A new strategy was therefore adopted for routine Rh typing of donations that includes typing first-time donors on the Groupamatic for C, D and E antigens; those that type as D-negative, C-positive and/or E-positive are further tested but no routine Du testing of D-, C- and E-negative donations is performed. Donations are labelled according to their D type, and the once used terminology 'Rh-positive donor, Rh-negative recipient' is no longer used except for those rare Rh D-positive donors belonging to the D category VI of Tippett & Sanger (1962).
Contreras
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North London Blood Transfusion Centre, Colindale, London.
Knight
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RC
D001771:Blood Banks / Q000592:standards; D001782:Blood Donors; D001788:Blood Grouping and Crossmatching; D004739:England; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D012203:Rh Isoimmunization; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D012204:Rh-Hr Blood-Group System