Epstein-Barr virus-associated lymphoproliferative disorder. Applications of immunoperoxidase and molecular biologic techniques.
A 17-year-old boy with fever and cervical lymphadenopathy developed multiple-organ failure and died three weeks after hospital admission. A lymph node biopsy specimen demonstrated a florid immunoblastic infiltrate that was suspicious for a malignant lymphoma. By using immunoperoxidase and molecular biologic techniques, evidence was presented for an Epstein-Barr virus-associated lymphoproliferative disorder.
Kornstein
M J
MJ
Department of Pathology, Medical College of Virginia, Richmond 23298-0662.
Weber
J
J
Luck
J B
JB
Massey
G V
GV
Strom
S
S
McWilliams
N B
NB
D000293:Adolescent; D004247:DNA / Q000032:analysis; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009693:Nucleic Acid Hybridization
D008565:Membrane Proteins; D004247:DNA