[Control of the side effects of ketamine: chlordemethyldiazepam vs diazepam in pre-anesthesia].
The pre-operative circulatory and psychotomimetic side-effects are studied in one hundred patients undergoing elective plastic-reconstructive surgery and anesthetized by ketamine 5-8 mg/kg i.m. Fifty patients were premedicated by atropine 0.01 mg/kg + CDDz 0.0285 mg/kg i.m. (group C), fifty by atropine 0.01 mg/kg + Dz 0.14 mg/kg i.m. (group D). All patients breathed spontaneously. Statistical analysis was performed with X 2 test. Not statistical difference was observed for the circulatory side-effects, whereas the frequency of emergence phenomena fell significantly from 31% to 14% (p less than 0.05) with CDDZ in greater than 16 years old patients. These finding seem confirm that CDDZ is more effective than DZ in reducing the psychotomimetic side-effects of ketamine, though it may be recommended a its wider experiment in this connection.
D'Eramo
C
C
Stocchetti
N
N
Iacovelli
W
W
Salvadori
A
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007649:Ketamine / Q000009:adverse effects*; D008297:Male; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011229:Preanesthetic Medication
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; D007649:Ketamine; C013434:chlordesmethyldiazepam; D003975:Diazepam
Controllo degli effetti collaterali della ketamina: clordemetildiazepam vs diazepam in preanestesia.