Interaction between cisplatin and mesna in mice.
The uroprotectant thiol mesna was found to protect adult CD-1 mice from high-dose cisplatin lethality. Mesna doses of 50 mg/kg were given with cisplatin, or 5 min after cisplatin (25 or 30 mg/kg) and acute survival was increased in non-tumor-bearing mice. In contrast, mesna mixed directly with cisplatin significantly reduced cisplatin antitumor effects in DBA/2J mice given 10(6) P-388 leukemia i.p. Mesna administered i.p. 5 min after cisplatin (6, 8 or 10 mg/kg) did not reduce cisplatins' antitumor efficacy in this same tumor model. Mesna appears to inactivate cisplatin directly in vitro but possibly not in vivo if separate injections are used.
Dorr
R T
RT
Arizona Cancer Center, Department of Internal Medicine, College of Medicine, University of Arizona, Tucson.
Lagel
K
K
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004347:Drug Interactions; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude
D008623:Mercaptoethanol; D015080:Mesna; D002945:Cisplatin