Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.
The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.
Datiles
M B
MB
National Eye Institute, Bethesda, MD 20892.
Fukui
H
H
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology; D004195:Disease Models, Animal; D007093:Imidazoles / Q000627:therapeutic use*; D048289:Imidazolidines; D007908:Lens, Crystalline / Q000473:pathology; D012377:Rodentia / Q000502:physiology*; D013311:Streptozocin; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D007093:Imidazoles; D048289:Imidazolidines; D013311:Streptozocin; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; C026411:sorbinil