title: Time-course of the changes in blood pressure and in plasma renin activity during the first week after dilation of renal artery stenosis.
abstract: We measured arterial pressure and plasma renin activity throughout the first week after a technically successful percutaneous transluminal renal angioplasty (PTRA) in 12 patients with hypertension and unilateral renal artery stenosis. Mean arterial pressure fell from 126 +/- 4 to 105 +/- 3 mmHg within 1-2 days of PTRA and stabilized thereafter; in addition, plasma renin activity decreased sharply during the first 2 days after the angioplasty (from 5.2 +/- 2.3 to 1.3 +/- 0.3 ng/ml per h) but continued to decline, reaching 0.8 +/- 0.2 ng/ml per h at the end of the study. When the antihypertensive effect of PTRA was examined in relation to baseline values of plasma renin activity, the patients with low, intermediate and high plasma renin activity showed percentage decreases in mean arterial pressure of, respectively, 6%, 16% and 19% by the sixth day of observation after the angioplasty. No overall correlation was found between the changes in arterial pressure and those in plasma renin activity induced by PTRA. These data suggest that the beneficial effect of PTRA on blood pressure can be estimated within a few days and that the reduction in the activity of the renin system is the principal but not the sole mechanism responsible for it.
authors.affiliation: Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Morganti
authors.forename: P
authors.initials: P
authors.lastname: Quorso
authors.forename: P
authors.initials: P
authors.lastname: Ferraris
authors.forename: A
authors.initials: A
authors.lastname: Lovaria
authors.forename: M
authors.initials: M
authors.lastname: Fruscio
authors.forename: S
authors.initials: S
authors.lastname: Saccheri
authors.forename: A
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D001794:Blood Pressure / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012077:Renal Artery; D012078:Renal Artery Obstruction / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D012083:Renin / Q000097:blood*; D013997:Time Factors
chemical_list: D012083:Renin