Cation transport in lymphoblastoid cell lines established from bipolar manic-depressive patients.
Lymphoblastoid cell lines established from patients suffering from bipolar manic depression have been used to study the possible involvement of cation transport in the aetiology of this illness. No significant difference was found in the K+ fluxes mediated by the ouabain-sensitive sodium pump, the diuretic-sensitive cotransport system and the passive leak pathway of cell lines established from either control or bipolar subjects. The mean value for the specific binding of 3H-ouabain (sodium pump site number) was significantly higher in the bipolar group (approximately 30%) than in the control group.
Banks
R E
RE
Department of Biology and Preclinical Medicine, University of St Andrews, U.K.
Aiton
J F
JF
Naylor
G J
GJ
Cramb
G
G
Wright
A F
AF
Griffith
R C
RC
Reich
T
T
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000235:genetics*; D002461:Cell Line, Transformed; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008564:Membrane Potentials; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000502:physiology*; D011955:Receptors, Drug / Q000502:physiology; D012307:Risk Factors; D015222:Sodium Channels / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase
D015221:Potassium Channels; D011955:Receptors, Drug; D015222:Sodium Channels; C028996:cardiac glycoside receptors; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium