Effects of neonatal capsaicin treatment and streptozotocin-induced diabetes on urinary bladder function in rats.
A significant increase in the size and weight of the urinary bladder was observed 2 weeks after streptozotocin treatment and 2 months after neonatal capsaicin treatment. Both treatments induced a significant increase in the level of [3H]quinuclidinyl benzilate binding to muscarinic cholinergic receptors in the urinary bladder membranes. However, contractile responses of urinary bladder muscle strips to carbachol (0.3-20 microM) were not significantly affected by either treatment. On the other hand, neonatal capsaicin treatment, but not streptozotocin treatment, significantly enhanced contractile responses of bladder strips to electric field stimulation.
Lee
C M
CM
Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin.
Wong
C C
CC
D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D004558:Electric Stimulation; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009929:Organ Size; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism; D013311:Streptozocin; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*
D011976:Receptors, Muscarinic; D013311:Streptozocin; D011813:Quinuclidinyl Benzilate; D002217:Carbachol; D002211:Capsaicin