[In vitro effect of cefixime against 200 strains of Branhamella catarrhalis. Comparison with cefotaxime].
The in vitro activity of cefixime was tested against 200 strains of Branhamella catarrhalis. Of these strains, 146 had been collected during 1987 from 15 different "Centres hospitaliers généraux", through a multicenter collaborative investigation organized by the "Collège de Bactériologie-Virologie-Hygiène des hôpitaux généraux". The remaining 54 strains were isolated at the "Centre hospitalier", of Aix-en-Provence. The strains originated from: bronchopulmonary collections: 80.2 per cent, sinusitis: 5.6 per cent, conjunctivitis: 4.6 per cent, otitis: 3.5 per cent, blood cultures: 0.5 per cent, miscellaneous: 5.6 per cent. Seventy-three per cent of the strains produced beta-lactamases. MIC determination was performed according to the agar dilution procedure on non-enriched Mueller-Hinton agar (30 hours incubation at 37 degrees C without CO2). The inoculum was 10(5) CFU per spot. Non beta-lactamase producing strains displayed the following MIC 50 and MIC 90 values (mg/l): amoxicillin: 0.03 - 0.125; cefotaxime: 0.06 - 1; cefixime: 0.06 - 0.5. Beta-lactamase producing strains were generally more resistant: amoxicillin: 32 - 128; cefotaxime: 1 - 2, and cefixime: 0.5 - 1.
Chardon
H
H
Laboratoire de Bactériologie-Biochimie, Centre Hospitalier Général, Aix-en-Provence.
Bellon
O
O
Lagier
E
E
Giraud
E
E
D000658:Amoxicillin / Q000494:pharmacology; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects*; D015337:Multicenter Studies as Topic; D001618:beta-Lactamases
D000658:Amoxicillin; D020682:Cefixime; D001618:beta-Lactamases; D002439:Cefotaxime
Activité in vitro du céfixime sur 200 souches de Branhamella catarrhalis. Comparaison au céfotaxime.