Phosphate binding efficiency of a polyuronic acid in normal subjects.
We evaluated the phosphate-binding efficiency of Sorbiphos, a non-toxic aluminium-free natural polymer, in five volunteers aged 28-34 years with normal renal function. After an overnight fast, a placebo, 2 g of Sorbiphos or a therapeutic dose of Alu-Cap (950 mg) were given, 30 min before a dietary load of phosphorus. Serum and urinary phosphate were measured on hourly samples. A similar increment in serum and urine phosphate was noted after the ingestion of placebo or Sorbiphos, but both serum and urine phosphate increased less after Alu-Cap. Since the recommended dose of Sorbiphos is half that of Alu-Cap, we conclude that Sorbiphos has little phosphate-binding efficiency in normal subjects given moderate phosphate loads.
Hamdy
N A
NA
Department of Human Metabolism, University of Sheffield Medical School, UK.
McCloskey
E V
EV
Naylor
V A
VA
Brown
C B
CB
Kanis
J A
JA
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011108:Polymers / Q000494:pharmacology*; D012016:Reference Values; D014574:Uronic Acids / Q000494:pharmacology*
D010710:Phosphates; D011108:Polymers; C063220:Sorbiphos; D014574:Uronic Acids; D000536:Aluminum Hydroxide