title: Continuous arteriovenous haemofiltration in the newlyborn with acute renal failure and congenital heart disease.
abstract: Newlyborn infants with congenital heart disease who develop acute renal failure are particularly difficult to treat. There are often complex associated medical problems and the mortality is high. Continuous arteriovenous haemofiltration (CAVH) provides a slow and gentle removal of fluid, together with the possibility of correcting metabolic abnormalities. We used CAVH in six newlyborn infants all with severe congenital heart disease, who developed acute renal failure early in life. In four patients it was necessary to insert a blood pump into the circuit to maintain adequate blood flow. CAVH alone, with or without a blood pump, was unable to reduce the plasma urea and creatinine, and in three of the infants, dialysis across the filter was required. CAVH was effective in controlling fluid balance. Although mortality remains high we feel CAVH has an important role in selected patients.
authors.affiliation: Department of Paediatrics, St James's University Hospital, Leeds, UK.
authors.forename: D
authors.initials: D
authors.lastname: Heney
authors.forename: J T
authors.initials: JT
authors.lastname: Brocklebank
authors.forename: N
authors.initials: N
authors.lastname: Wilson
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy*; D006330:Heart Defects, Congenital / Q000097:blood*; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007260:Infusion Pumps; D006435:Renal Dialysis; D014508:Urea / Q000097:blood; D014882:Water-Electrolyte Balance
chemical_list: D014508:Urea