Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.
The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.
Hensens
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OD
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
Goldberg
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IH
D000903:Antibiotics, Antineoplastic; D001894:Borohydrides; D055598:Chemical Phenomena; D002621:Chemistry; D053281:Enediynes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013864:Thioglycolates; D009353:Zinostatin / Q000031:analogs & derivatives
D000903:Antibiotics, Antineoplastic; D001894:Borohydrides; D053281:Enediynes; D013864:Thioglycolates; C032372:neocarzinostatin chromophore; C025364:sodium borohydride; D009353:Zinostatin; C037474:methyl thioglycolate