Specificity of the dexamethasone-induced steroid receptor in Tetrahymena.
The dexamethasone-induced steroid receptor of Tetrahymena pyriformis specifically binds triamcinolone, which is itself a fluorinated glucocorticoid. It also binds dihydro-epi-androsterone (DHEA) but no or very little testosterone, digoxin or ouabain. It follows that the specificity of the induced steroid receptor of Tetrahymena may only partially be comparable with that of the mammalian steroid receptor.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
D000818:Animals; D003687:Dehydroepiandrosterone / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D004077:Digoxin / Q000378:metabolism; D010042:Ouabain / Q000378:metabolism; D011987:Receptors, Steroid / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism; D013769:Tetrahymena pyriformis / Q000378:metabolism*; D014221:Triamcinolone / Q000378:metabolism
D011987:Receptors, Steroid; D014221:Triamcinolone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D010042:Ouabain; D004077:Digoxin; D003907:Dexamethasone