Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr time period, they are triggered by 15 min of seizure. Alterations in the levels and composition of transcription factors may represent one of the molecular mechanisms underlying neuronal adaptation.
Sonnenberg
J L
JL
Department of Molecular Oncology and Virology, Roche Research Center, Nutley, New Jersey 07110.
Macgregor-Leon
P F
PF
Curran
T
T
Morgan
J I
JI
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010433:Pentylenetetrazole; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun; D012640:Seizures / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D001569:Benzodiazepines; D010433:Pentylenetetrazole