title: [Liver damage caused by psychopharmaceuticals].
abstract: Liver plays a central role in drug metabolism, particularly in uptake, biotransformation and excretion of metabolites. Among these metabolic steps biotransformation represents the most critical factor in drug-induced liver damage, especially when hepatic protective mechanisms, such as the tripeptide glutathione (GSH), are decreased thereby predisposing to lipid peroxidation of biological membranes. The authors focus on the prevalence of hepatic damage in a population of patients chronically treated with psychotropic drugs and divided according to the therapeutic schedule and the type of drug. It is shown that the liver damage induced by psychopharmacologic treatment correlates in a group of 15 patients with a significant decrease of hepatic glutathione.
authors.forename: E
authors.initials: E
authors.lastname: Altomare
authors.forename: G
authors.initials: G
authors.lastname: Vendemiale
authors.forename: V
authors.initials: V
authors.lastname: Procacci
authors.forename: A
authors.initials: A
authors.lastname: Giovine
authors.forename: N
authors.initials: N
authors.lastname: Di Reda
authors.forename: O
authors.initials: O
authors.lastname: Albano
mesh_terms: D000328:Adult; D000368:Aged; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000493:pharmacokinetics
chemical_list: D011619:Psychotropic Drugs; D005978:Glutathione
vernacular_title: Danno epatico da psicofarmaci.