c-AMP-induced c-fos expression in cells of melanocyte origin.
The expression of the c-fos gene in murine cells of melanocyte origin in response to cAMP-elevating agents has been examined. Accumulation of c-fos mRNA at a high level as a consequence of these treatments precedes both proliferative and cytodifferentiative changes in non-tumorigenic or tumorigenic cell lines.
Hart
I R
IR
Imperial Cancer Research Fund Laboratories, London.
Rao
J
J
Wilson
R E
RE
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002772:Cholera Toxin; D000242:Cyclic AMP / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D007700:Kinetics; D008544:Melanocytes / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes / Q000187:drug effects; D000521:alpha-MSH
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D000521:alpha-MSH; D002772:Cholera Toxin; D000242:Cyclic AMP