A histological study of the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric and duodenal mucosa.
The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric and duodenal mucosa was studied in 53 patients. On endoscopic biopsies, 87% patients showed gastritis and 90% duodenitis. Chronic superficial gastritis was the most frequent lesion in the stomach (49%); and mild duodenitis in the duodenum (54%). The antrum was the most frequently involved site in the stomach. An interesting finding in cases of duodenitis was the presence of dilated intestinal glands plugged with mucus.
Moghal
N
N
Jafarey
N A
NA
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004382:Duodenitis / Q000139:chemically induced* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal