title: Factors influencing the response to hepatitis B vaccination of hemodialysis patients.
abstract: The response rate and HBsAG antibody concentrations were examined after hepatitis B vaccination in 78 hemodialysis patients aged between 29 and 79 years. The values were related to age, duration of hemodialysis, body weight, creatinine, urea nitrogen, serum concentrations of beta 2-microglobulin and soluble interleukin-2 receptor (IL-2R). Patients with low anti-HBsAG antibody concentrations (10-100 mU/ml) had significantly higher IL-2R serum concentrations than those with high anti-HBsAG antibody concentrations (greater than 3,000 mU/ml; p less than 0.05). Discriminant multivariate analysis (p = 0.032) revealed the influence (62%) of IL-2R on the response rate while other factors were similar in all patient groups. It is concluded that preactivation of T cells with an increased release of IL-2R may contribute to impaired immune response after hepatitis B vaccination.
authors.affiliation: Abteilung für Allgemeine Innere Medizin und Nephrologie, Freie Universität, Berlin.
authors.forename: G
authors.initials: G
authors.lastname: Walz
authors.forename: U
authors.initials: U
authors.lastname: Kunzendorf
authors.forename: H
authors.initials: H
authors.lastname: Haller
authors.forename: F
authors.initials: F
authors.lastname: Keller
authors.forename: G
authors.initials: G
authors.lastname: Offermann
authors.forename: O
authors.initials: O
authors.lastname: Josimovic-Alasevic
authors.forename: T
authors.initials: T
authors.lastname: Diamantstein
mesh_terms: D000328:Adult; D000368:Aged; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology; D014761:Viral Hepatitis Vaccines
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D015375:Receptors, Interleukin-2; D014761:Viral Hepatitis Vaccines