[The transmembrane diffusion of trinitrine and isosorbide dinitrate. Study of artificial membranes].
Nitroglycerin pharmacodynamic efficiency is 3 to 4 times higher than isosorbide dinitrate efficiency. Data of this study on physiological and artificial membranes point the greater nitroglycerin transmembrane diffusion, which is discussed as a possible relevant explanation.
Guyot-Hermann
A M
AM
Ringard
J
J
Parier
J L
JL
Lefebvre
C
C
Barthelemy
C
C
D002463:Cell Membrane Permeability; D004058:Diffusion; D004912:Erythrocytes / Q000648:ultrastructure; D006801:Humans; D007548:Isosorbide Dinitrate / Q000493:pharmacokinetics*; D008567:Membranes, Artificial; D005996:Nitroglycerin / Q000493:pharmacokinetics*
D008567:Membranes, Artificial; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
Etude du passage transmembranaire de la trinitrine et du dinitrate d'isosorbide. Etude sur membrane artificielle.