title: Highly restricted tumor-specific antigen of radiation leukemia virus-induced murine leukemias.
abstract: A tumor-specific Ag expressed by the radiation leukemia virus-induced BALB/c leukemia BALBRVC has been serologically and biochemically identified with mAb of rat origin--RH221 and RH16. These mAb recognize two distinct epitopes on a Mr 85,000 glycoprotein. Expression of the RH221/16 Ag was also detected on two radiation leukemia virus-induced C57BL/6 leukemias, B6RV1 and B6RV2. The Ag was not detected on 66 other leukemias, 16 sarcomas, or 19 normal tissues tested. The results of sequential immunoprecipitation and partial peptide analyses of the RH221/16 Ag indicate that this tumor-specific Ag is immunologically and structurally distinct from murine leukemia virus-related determinants expressed on the three RH221/16+ leukemias.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York 10021.
authors.forename: A
authors.initials: A
authors.lastname: Meseguer
authors.forename: Y
authors.initials: Y
authors.lastname: Obata
authors.forename: E
authors.initials: E
authors.lastname: Stockert
authors.forename: A B
authors.initials: AB
authors.lastname: DeLeo
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D000957:Antigens, Viral, Tumor / Q000276:immunology / Q000302:isolation & purification*; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007953:Leukemia, Radiation-Induced / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011233:Precipitin Tests; D051381:Rats; D011920:Rats, Inbred WF; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000302:isolation & purification
chemical_list: D000911:Antibodies, Monoclonal; D000957:Antigens, Viral, Tumor; D008562:Membrane Glycoproteins; D014764:Viral Proteins; C028388:thymus-leukemia antigens