On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon.
The results of the segregation analysis of hereditary adenomatous polyposis and primary cancer of the colon are given, taking into account the age-dependent manifestation of genotypes and the specificity of pedigree sampling. The results are used for testing the hypothesis of pleiotropic monogenic control of these two colon pathologies.
Ginsburg
E K
EK
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk.
Axenovich
T I
TI
Altshouler
B A
BA
Bazhenova
M D
MD
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003110:Colonic Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D010375:Pedigree; D011336:Probability