Rat atrial natriuretic peptide stimulates K+ fluxes in human erythrocytes.
Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our results suggest that the hormone can modify transmembrane K+ movements.
Esparza
N
N
Servicio de Nefrología, Clínica Universitaria, Universidad de Navarra, Spain.
Díez
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002034:Bumetanide / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D011803:Quinine / Q000494:pharmacology; D051381:Rats
D002034:Bumetanide; D000001:Calcimycin; D004533:Egtazic Acid; D010042:Ouabain; D009320:Atrial Natriuretic Factor; D011803:Quinine; D011188:Potassium; D002118:Calcium