Expression of membrane receptors and (proto)oncogenes during the ontogenic development and neoplastic transformation of the intestinal mucosa.
The functional relationship between membrane receptors involved in signal transduction and (proto) oncogene expression has been explored during the ontogenic development and differentiation of the intestinal mucosa in man and rat. The present review develops detailed picture of the current understanding of some mechanisms underlying growth and function of normal, immortalized and cancerous intestinal epithelial cells.
Chastre
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INSERM U.55, Unité de Recherches sur les Peptides Neurodigestifs et le Diabète, Hôpital Saint-Antoine, Paris, France.
Emami
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S
Gespach
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C
D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000254:growth & development*; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D051381:Rats; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism*; D018005:Receptors, Vasoactive Intestinal Peptide; D015398:Signal Transduction
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011964:Receptors, Gastrointestinal Hormone; D018005:Receptors, Vasoactive Intestinal Peptide