Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.
The structural gene for membrane cofactor protein (MCP), a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system, has been mapped to the same locus as the structural genes for CR1, CR2, DAF, and C4bp. The order of the genes within an approximately 800-kb DNA fragment on the long arm of chromosome 1 is MCP-CR1-CR2-DAF-C4bp. Further, the MCP gene maps to within 100 kb of 3' end of the CR1 gene.
Bora
N S
NS
Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St. Louis, Missouri 63110.
Lublin
D M
DM
Kumar
B V
BV
Hockett
R D
RD
Holers
V M
VM
Atkinson
J P
JP
D015703:Antigens, CD; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000235:genetics*; D011951:Receptors, Complement / Q000235:genetics; D017463:Receptors, Complement 3b; D015183:Restriction Mapping
D015703:Antigens, CD; C497857:CD46 protein, human; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011951:Receptors, Complement; D017463:Receptors, Complement 3b