title: [The number and ultrastructure of CD4+ lymphocytes in the blood of healthy persons and in patients with type 1 diabetes mellitus].
abstract: The flowing cytofluorometric and electron microscopic methods have been used to study the content and ultrastructure of blood CD4 lymphocytes in healthy and type I diabetic patients. Analysis of submicroscopic structure of the lymphocytes expressing CD4 antigen has revealed its morphological heterogeneity. It has permitted distinguishing four groups of cells. A decrease of the content of CD4+ lymphocytes at the expense of the first group cells and relative increase in the number of the fourth-group cells are observed in the majority of diabetic patients. The availability of parallel-tubular structures in granules forming clusters and first-group lymphocytes, an increase in the number and size of granules of the fourth-group are the most typical changes of ultrastructural characteristics.
authors.forename: R M
authors.initials: RM
authors.lastname: Khomenko
authors.forename: M A
authors.initials: MA
authors.lastname: Gruzov
authors.forename: V S
authors.initials: VS
authors.lastname: Shliakhovenko
authors.forename: D I
authors.initials: DI
authors.lastname: Lukinov
authors.forename: S V
authors.initials: SV
authors.lastname: Komissarenko
authors.forename: K P
authors.initials: KP
authors.lastname: Zak
mesh_terms: D015704:CD4 Antigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008854:Microscopy, Electron; D012016:Reference Values; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000648:ultrastructure
chemical_list: D015704:CD4 Antigens
vernacular_title: Soderzhanie u u'ltrastruktura CD4+-limfotsitov krovi zdorovykh liudeĭ i bo'lnykh sakharnym diabetom I tipa.