[Effects of hyperlipidemic sera and lipoproteins on prostacyclin synthesis by rabbit aortic smooth muscle cells].
Effects of hyperlipidemic sera(HLS), serum high density lipoprotein (HDL) and low density lipoprotein (LDL) were studied on synthesis of prostacyclin (PGI2) by rabbit aortic smooth muscle cells (SMC) in culture. The results indicated that HDL induced a dose-dependent increase in synthesis of PGI2 by SMC. Although LDL at comparable cholesterol concentrations of HDL also induced increase in PGI2 synthesis in a dose-dependent pattern, the extent was much less than that of HDL. SMC incubated with HDL and hyperlipid + aspirin treated serum synthesized less PGI2 as compared with that incubated with normal serum, while SMC incubated with hyperlipid + 8501 treated serum produced, an amount of PGI2 closed to that after incubation with normal serum, it suggested that 8501 may stimulate directly PGI2 synthetase in SMC.
Hu
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Wang
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D000818:Animals; D001011:Aorta; D002478:Cells, Cultured; D011464:Epoprostenol / Q000096:biosynthesis*; D006949:Hyperlipidemias / Q000097:blood; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011464:Epoprostenol