title: S-100 protein immunoreactivity in human islets of Langerhans.
abstract: S-100 protein-containing cells were demonstrated by immunogold silver staining in human islets of Langerhans from patients with chronic pancreatitis (CP) with (n = 6) (Group I) or without (n = 6) (Group II) diabetes mellitus, (DM) and from nondiabetic, non-pancreatic controls (n = 6) (Group III). In all three groups S-100 protein containing cells were observed in all islets of Langerhans throughout the pancreas. Quantitative analysis of cell composition of islets did not reveal significant differences in S-100 protein cell content between the three groups. When double immunohistochemical staining was used to demonstrate different endocrine cell types (insulin, glucagon and pancreatic polypeptide) and S-100 protein immunoreactive cells, the latter proved to be a distinct cell type. Somatostatin-producing cells and S-100 protein-containing cells were usually also present as two distinct cell populations, but positive staining for both S-100 protein and somatostatin was occasionally observed within the same cells.
authors.affiliation: Departm. of Pathology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Lászik
authors.forename: T
authors.initials: T
authors.lastname: Krenács
authors.forename: E
authors.initials: E
authors.lastname: Dobó
mesh_terms: D002908:Chronic Disease; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000032:analysis* / Q000473:pathology; D010195:Pancreatitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D009418:S100 Proteins