Pineal gland in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors subjected to manipulations known as enhancers of pineal actions.
The ultrastructure of pinealocytes was studied in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors which were subjected to experimental manipulations known as enhancers of pineal actions (anosmia, underfeeding or cold exposure). In these animals we found: (I)--more nuclei with deep nuclear invaginations; (II)--a large number of cytoplasmic organelles, including lipid droplets, myeloid bodies, synaptic ribbons and lysosomes; (III)--numerous degenerative changes. In general, we found an increase in structural features related to pineal photoneuroendocrine activity. Our results indicate that pineal-dependent inhibition of neoplastic growth induced by these experimental manipulations, previously reported, can be mediated through an increase in pineal metabolic activity.
Cos
S
S
Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain.
Bardasano
J L
JL
Mediavilla
M D
MD
Sánchez Barceló
E J
EJ
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001766:Blindness / Q000503:physiopathology; D003080:Cold Temperature; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D009748:Nutrition Disorders / Q000503:physiopathology; D000857:Olfaction Disorders / Q000503:physiopathology; D009830:Olfactory Bulb / Q000502:physiology; D010870:Pineal Gland / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D015127:9,10-Dimethyl-1,2-benzanthracene