Chronic myelomonocytic leukemia with chromosomal changes involving 1p36 and hepatocellular carcinoma in a case of Fanconi's anemia.
A girl with Fanconi's anemia developed chronic myelomonocytic leukemia and hepatocellular carcinoma. At the time that chronic myelomonocytic leukemia was diagnosed, all metaphases of the bone marrow cells revealed a chromosomal translocation involving 1p36. It is suggested that the occurrence of this rare type of leukemia in our patient is related to the chromosomal translocation.
Bessho
F
F
Department of Pediatrics, University of Tokyo Hospital, Japan.
Mizutani
S
S
Hayashi
Y
Y
Moriwaki
K
K
Yokota
S
S
Inaba
T
T
D000741:Anemia, Aplastic / Q000150:complications*; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000235:genetics; D002648:Child; D002878:Chromosomes, Human, Pair 1; D005199:Fanconi Anemia / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics*; D008113:Liver Neoplasms / Q000150:complications* / Q000235:genetics; D009378:Neoplasms, Multiple Primary; D014178:Translocation, Genetic