title: [Combined chemotherapy with the FEM protocol in advanced gastric cancer].
abstract: Thirty one patients with diagnosis of Gastric Cancer were admitted in this study. Median age was 71 years (range 24-82). Twenty two were male. No one had previous chemotherapy. Functional capacity was 0-1 in 26/31 (60.6%). More common symptoms were: loss of weight 21/31 (75.1%) and abdominal pain in 13/31 (40.3%). Ten patients were Borrmann III and nine Borrmann IV. Twenty one had surgery: 12 palliative gastrectomy and 9 exploratory laparatomy. Twenty three cases were adenocarcinoma and 8 undifferentiated carcinoma. FEM regimen was administered (5 Fluoruracil 600 mg/m2/day 1 and 8, Epidoxorubicin 30 mg/m2/day 1 and Mitomycin 10 mg/m2/day 1). Ten of 24 patients (41.7%) achieved partial remission with a median survival of 10.5 months. Three patients achieved subjective response with a median survival of 6 months. Median survival for the non response was 3 months (range 2-7 months). Survival difference between responders and no responders was statistically significant. Survival among the adjuvent group was 5.7 months (range 2-16 months). One out of three patients survived without evidence of disease at the end of this study. Twenty three patients died and 5 were lost to follow up. Alopecia was the most common secondary effect in 74%, nausea and vomiting in 60% and leukopenia below 3000 x mm3 in 54%. Cardiotoxicity was not documented in any case.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
authors.forename: C
authors.initials: C
authors.lastname: Vallejos
authors.forename: C
authors.initials: C
authors.lastname: Payet
authors.forename: J
authors.initials: J
authors.lastname: Nuñez
authors.forename: J
authors.initials: J
authors.lastname: Montalbetti
authors.forename: A
authors.initials: A
authors.lastname: Solidoro
authors.forename: F
authors.initials: F
authors.lastname: Salazar
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Celis
authors.forename: L
authors.initials: L
authors.lastname: Casanova
authors.forename: J
authors.initials: J
authors.lastname: Otero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015251:Epirubicin; D016685:Mitomycin; D005472:Fluorouracil
vernacular_title: Quimioterapia combinada con el esquema FEM en cáncer gástrico avanzado.