title: G-proteins and second messengers in mitogenesis.
abstract: Growth factors stimulate mitogenesis via the generation of signal molecules or events. Transduction of these messages into the cell proceeds by the binding of the mitogen to a specific cell surface receptor which then stimulates the effector system (enzyme, ion channel, etc.) via a guanine nucleotide binding regulatory protein (G-protein). The specificity of a particular G-protein is a function of its unique alpha-subunit. This article reviews the effects of different growth factors upon second messenger generation and discusses the involvement of the different G-proteins in these signal transduction pathways.
authors.affiliation: Department of Biochemistry and Pharmacology, University of Glasgow, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Milligan
authors.forename: M J
authors.initials: MJ
authors.lastname: Wakelam
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D015290:Second Messenger Systems; D015398:Signal Transduction
chemical_list: D006133:Growth Substances; D019204:GTP-Binding Proteins