[Evaluation of the cardiac and peripheral vascular effects of the administration of single-dose enalapril and captopril in essential arterial hypertension].
The effects of single orally-administered dose of enalapril and captopril on central and district-peripheral circulations have been studied in 20 patients with essential arterial hypertension. Either drug caused a decrease in arterial pressure, telesystolic and telediastolic parietal stress, and a reduction in the peripheral vascular resistance of upper limb district. Furthermore, at the upper limb district level, increases in arterial flow and venous-system capacity have been observed. The entity of these modifications induced by enalapril and captopril appeared comparable, according to the respective peak-time and used dosages. Under this study conditions, the difference between the drugs resulted to be essentially of chronological nature.
Longhini
C
C
Ansani
L
L
Musacci
G F
GF
Vaccari
M
M
Fraccaroli
G P
GP
Mele
D
D
Aggio
S
S
Baracca
E
E
D000328:Adult; D000368:Aged; D001132:Arm; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage* / Q000627:therapeutic use; D004452:Echocardiography; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D004656:Enalapril; D002216:Captopril
Valutazione degli effetti cardiaci e vascolari periferici della somministrazione in dose singola di enalapril e captopril nell'ipertensione arteriosa essenziale.