The sensitizing capacity of coumarins (III).
9 coumarins used as chemical reagents, laser dyes, in perfumery, cosmetics or occurring naturally, were investigated experimentally in guinea pigs to determine their contact sensitizing capacity. 5,7-dihydroxycoumarin, limettin and 5,7-dihydroxy-4-methylcoumarin were found to be moderate sensitizers, while scoparone, isoscopoletin and 4-hydroxycoumarin were weak. The 3 laser dyes were completely negative. The results indicate that substitution in the 6 and 7 or 5 and 7 positions with 2 hydroxy groups supports allergenic capability, while other substituents (e.g., methoxy groups) in the same positions, or an additional (third) substituent, diminish activity.
Hausen
B M
BM
Department of Dermatology, University Hospital, Hamburg, FRG.
Berger
M
M
D015110:4-Hydroxycoumarins / Q000009:adverse effects; D000818:Animals; D004396:Coloring Agents; D003358:Cosmetics / Q000009:adverse effects; D003374:Coumarins / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D003875:Drug Eruptions; D005260:Female; D006168:Guinea Pigs; D007834:Lasers; D010476:Perfume / Q000009:adverse effects; D012603:Scopoletin / Q000009:adverse effects; D014468:Umbelliferones / Q000009:adverse effects
D015110:4-Hydroxycoumarins; D004396:Coloring Agents; D003358:Cosmetics; D003374:Coumarins; D010476:Perfume; D014468:Umbelliferones; C018145:scoparone; D012603:Scopoletin; C007628:esculetin