Effects of tiaprofenic acid on interleukin 1, phospholipase A2 activity, prostaglandins, neutral protease, and collagenase activity in rheumatoid synovial fluid.
IL-1 and prostaglandin (PGE2, PGF2 alpha, TXB2) concentrations, PLA2 activity, neutral protease activity, and collagenase activity specific for types I and II collagen were determined in the SF of patients suffering from RA, before and after treatment with TA. Active and latent forms of protease and collagenases were regularly detected but were unrelated to IL-1, PLA2, and PGE2. TA induced a significant decrease in tested eicosanoids but IL-1, PLA2, and proteases were unchanged.
Vignon
E
E
Laboratoire d'Exploration Articulaire, Hopital Edouard Herriot, Lyon, France.
Mathieu
P
P
Couprie
N
N
Cloppet
H
H
Herbage
D
D
Louisot
P
P
Richard
M
M
D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000187:drug effects; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism*; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011422:Propionates / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D012216:Rheumatic Diseases / Q000378:metabolism*; D013582:Synovial Fluid / Q000187:drug effects*; D013929:Thromboxane B2 / Q000378:metabolism
D007375:Interleukin-1; D011422:Propionates; D011453:Prostaglandins; C021270:tiaprofenic acid; D013929:Thromboxane B2; D015237:Dinoprost; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D010447:Peptide Hydrolases; D003012:Microbial Collagenase; D015232:Dinoprostone