P53 and oncogenes expression in psoriasis.
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
Tadini
G
G
1st Department of Dermatology, University of Milan, Italy.
Cerri
A
A
Crosti
L
L
Cattoretti
G
G
Berti
E
E
D000911:Antibodies, Monoclonal; D001706:Biopsy; D002453:Cell Cycle; D002454:Cell Differentiation; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D015513:Oncogene Proteins / Q000032:analysis*; D009857:Oncogenes; D010750:Phosphoproteins / Q000032:analysis*; D011565:Psoriasis / Q000209:etiology / Q000235:genetics*; D016159:Tumor Suppressor Protein p53
D000911:Antibodies, Monoclonal; D015513:Oncogene Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53