[Antalgic efficacy of tiaprofenic acid in models of acute rheumatic pain].
Twenty patients suffering from acute lumbosacral syndromes (Group A) and eight patients suffering from acute gout (Group B) were treated with parenteral tiaprofenic acid (TA). In Group A TA was administered for 7 days at the dosage of 400 mg/daily for the first four days (1 200 mg vial i.m. in the morning, 1 in the evening), from the 5th to the 7th day with 200 mg/daily (1 vial in the evening) and, in Group B, TA was administered for 6 days at the dosage of 600 mg on the first day, (with 1 vial/8 hours of TA 200 mg by parenteral route) the 2nd and 3rd day with 1 vial/12 hours and the 4th and 6th day with 1 vial/daily in the evening. TA was found to be active on all clinical parameters evaluated. The tolerability was also good: only 4 patients with acute lumbosacral syndrome suffered from local pain.
Marcolongo
R
R
Frati
E
E
Biasi
G
G
Franci
A
A
Fioravanti
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D015210:Arthritis, Gouty / Q000188:drug therapy*; D001416:Back Pain / Q000188:drug therapy*; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*; D012585:Sciatica / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid
Studio dell'efficacia antalgica dell'acido tiaprofenico in modelli di dolore acuto reumatico.