[Erythrocyte oxidative damage by myeloperoxidase. The protective action of serum proteins].
Influence of main serum proteins (albumin, immunoglobulin G) and proteins-antioxidants (ceruloplasmin, transferrin, superoxide dismutase) on the oxidative damage of erythrocytes by myeloperoxidase and hypochlorite was investigated. The proteins were determined to act as protectors and decrease the degree of hemoglobin oxidation, ceruloplasmin and albumin possessing the highest antioxidant activity.
Govorova
N Iu
NIu
Sharonov
B P
BP
Lyzlova
S N
SN
D000818:Animals; D000975:Antioxidants; D001798:Blood Proteins / Q000378:metabolism*; D002021:Buffers; D002384:Catalysis; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D009195:Peroxidase / Q000302:isolation & purification / Q000494:pharmacology*; D013552:Swine
D000975:Antioxidants; D001798:Blood Proteins; D002021:Buffers; D009195:Peroxidase; D010100:Oxygen
Okislitel'noe povrezhdenie éritrotsitov mieloperoksidazoĭ. Zashchitnoe deĭstvie syvorotochnykh belkov.