title: Potentiation by nonspecific immunostimulation of the efficacy of antibiotics in the treatment of experimental bacterial infections.
abstract: In the present investigation, mouse infection models with either intracellular or extracellular bacteria were designed in order to assess the effect of nonspecific immunostimulation with the C. granulosum-derived P40 immunomodulator on infection treatment, performed with doses of antibiotics achieving a low percentage of cures. The results obtained showed that nonspecific immunostimulation was able to significantly enhance antibiotic therapy efficacy. In addition, combined treatments of bacterial infections should allow for a reduction in dosages of antibiotics while at the same time, achieving increased efficacy. Possible mechanisms for the potentiating effect of nonspecific immunostimulation on antibiotic therapy effectiveness are discussed.
authors.affiliation: Unité d'Immunochimie des Protéines, Institut Pasteur, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Bizzini
authors.forename: M
authors.initials: M
authors.lastname: Fattal-German
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001398:Aztreonam / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D003352:Corynebacterium; D004195:Disease Models, Animal; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use; D007710:Klebsiella Infections / Q000188:drug therapy; D051379:Mice; D018805:Sepsis / Q000097:blood; D013290:Streptococcal Infections / Q000188:drug therapy; D017334:Teicoplanin; D015534:Trans-Activators / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D015534:Trans-Activators; D017334:Teicoplanin; D000667:Ampicillin; D001398:Aztreonam