title: Source of pain and primitive dysfunction in migraine: an identical site?
abstract: Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglycerin, received the drug in a second induction test at other body areas. No early onset migraine was observed. Thus the migraine-inducing effect of nitroglycerin seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis. This is not consistent with a CNS origin of migraine attack.
authors.affiliation: Department of Neurology, Second School of Medicine, University of Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bonuso
authors.forename: E
authors.initials: E
authors.lastname: Marano
authors.forename: E
authors.initials: E
authors.lastname: di Stasio
authors.forename: F
authors.initials: F
authors.lastname: Sorge
authors.forename: F
authors.initials: F
authors.lastname: Barbieri
authors.forename: E A
authors.initials: EA
authors.lastname: Ullucci
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced*; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000009:adverse effects; D009824:Ointments; D016032:Randomized Controlled Trials as Topic; D013702:Temporal Lobe / Q000187:drug effects
chemical_list: D009824:Ointments; D005996:Nitroglycerin