Metabolic effects of three new low-dose pills: a six-month experience.
We evaluated the effects on glucose and lipid metabolism in 57 healthy volunteers randomly assigned to one of three low-dose oral contraceptives: two monophasic (desogestrel + ethinylestradiol, EE, and cyproterone acetate + EE) and one triphasic (gestodene + EE) contraceptives. Glucose and insulin responses during OGTT were slightly affected by the cyproterone pill. The insulin area/glucose area ratio and HbA1c level were unchanged in all women. No preparation affected total and LDL-cholesterol levels. Triglycerides rose in all groups, while HDL-CH did only in women taking the two monophasic pills. The three low-dose pills assessed in this study have negligible effects on glucose and lipid metabolism.
Miccoli
R
R
Instituto di Clinica Medica, Università di Pisa, Italy.
Orlandi
M C
MC
Fruzzetti
F
F
Giampietro
O
O
Melis
G
G
Ricci
C
C
Bertolotto
A
A
Fioretti
P
P
Navalesi
R
R
D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D009652:Norpregnenes / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology; D011897:Random Allocation; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
D000726:Androgen Antagonists; D001786:Blood Glucose; D003277:Contraceptives, Oral, Combined; D007328:Insulin; D009652:Norpregnenes; D045167:Progesterone Congeners; D014280:Triglycerides; C033273:Gestodene; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D017135:Desogestrel; D002784:Cholesterol; D003534:Cyproterone