An improved HPLC system for the analysis and purification of organic amine radiopharmaceuticals.
This paper describes the separation of lipophilic amine radiopharmaceuticals on normal phase silica using a reversed phase type eluant. This class of compound usually gives very poor peak symmetry on reversed phase columns. However, excellent separation of a number of amines of interest to Positron Emission Tomography, such as spiperone and its derivatives, has been achieved on this system.
Adam
M J
MJ
UBC/TRIUMF Program on Positron Emission Tomography, Vancouver, Canada.
Grierson
J R
JR
Jivan
S
S
D001552:Benzazepines / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005069:Evaluation Studies as Topic; D020891:Raclopride; D011849:Radioactive Tracers / Q000032:analysis / Q000302:isolation & purification; D012457:Salicylamides / Q000032:analysis* / Q000302:isolation & purification
C059321:8-chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol; D001552:Benzazepines; D011849:Radioactive Tracers; D012457:Salicylamides; D020891:Raclopride