Vacuolar proton pumps.
Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria.
Stone
D K
DK
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235.
Crider
B P
BP
Südhof
T C
TC
Xie
X S
XS
D000818:Animals; D007425:Intracellular Membranes / Q000201:enzymology; D046911:Macromolecular Substances; D006180:Proton-Translocating ATPases / Q000145:classification / Q000378:metabolism*; D014617:Vacuoles / Q000201:enzymology*
D046911:Macromolecular Substances; D006180:Proton-Translocating ATPases