Early response and induced tolerance to cycloheximide in Neurospora crassa.
Incubation of Neurospora crassa mycelia with low doses of cycloheximide induces the expression of several genes. After 6 h in the presence of cycloheximide, mycelia become tolerant to further additions of the drug and the rate of protein synthesis exhibits a lower sensitivity to it. The polypeptide pattern is indicative of a stress situation.
Grotewold
E
E
Instituto de Investigaciones en Ingenieria Genética y Biologia Molecular (INGEBI), Buenos Aires, Argentina.
Taccioli
G E
GE
Aisemberg
G O
GO
Judewicz
N D
ND
D003513:Cycloheximide / Q000494:pharmacology*; D004361:Drug Tolerance; D004591:Electrophoresis, Polyacrylamide Gel; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D005800:Genes, Fungal; D007700:Kinetics; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D012331:RNA, Fungal / Q000235:genetics; D013696:Temperature; D014158:Transcription, Genetic
D005656:Fungal Proteins; D012331:RNA, Fungal; D003513:Cycloheximide