Antibody-dependent enhancement of yellow fever and Japanese encephalitis virus neurovirulence.
Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.
Gould
E A
EA
Arbovirus Research Unit, St Albans, Hertfordshire, U.K.
Buckley
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D001927:Brain Diseases / Q000276:immunology / Q000382:microbiology; D004664:Encephalitis Virus, Japanese / Q000276:immunology / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000276:immunology / Q000382:microbiology; D051379:Mice; D009500:Neutralization Tests; D014774:Virulence; D015004:Yellow Fever / Q000276:immunology / Q000382:microbiology; D015005:Yellow fever virus / Q000276:immunology / Q000472:pathogenicity*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral