Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum.
Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.
Hirsch
E C
EC
INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Graybiel
A M
AM
Hersh
L B
LB
Duyckaerts
C
C
Agid
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology* / Q000503:physiopathology; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology*; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology
D002795:Choline O-Acetyltransferase