Effects of 8-OH-DPAT and ipsapirone in the tests used for evaluation of the antidepressant action.
8-OH-DPAT and ipsapirone were studied in rats and mice in the tests used for preclinical assessment of antidepressant activity, 8-OH-DPAT shortened the immobility time in the behavioral despair test in rats and mice and counteracted the hypothermia induced by reserpine or apomorphine, whereas ipsapirone revealed only a weak activity in the despair test in rats but not in mice, and was inactive in the hypothermia induced by reserpine or apomorphine. The antireserpine action of 8-OH-DPAT was reduced by haloperidol and also by ipsapirone less potently, though. The obtained results indicate that 8-OH-DPAT acts similarly to typical antidepressants in behavioral tests regarded as specific, whereas ipsapirone is devoid of such an action.
Tatarczyńska
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Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Chojnacka-Wójcik
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E
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D000928:Antidepressive Agents; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D009281:Naphthalenes; D011743:Pyrimidines; D013764:Tetrahydronaphthalenes; C043077:ipsapirone; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D012110:Reserpine; D001058:Apomorphine