title: Infertility in heifers inoculated with modified-live bovine herpesvirus-1 vaccinal strains against infectious bovine rhinotracheitis on postbreeding day 14.
abstract: Heifers were inoculated IV with 1 of 4 modified-live bovine herpesvirus-1 vaccinal strains against infectious bovine rhinotracheitis (2 heifers/strain) on postbreeding day (PBD) 14. The effect of infection on fertility was monitored by plasma progesterone assay at 1- to 3-day intervals from the time of virus exposure until PBD 60. Infertility was detected in 4 of 8 inoculated heifers. In 2 heifers, progesterone concentrations decreased to values indicative of estrus within 10 days after inoculation (PBD 24). The 2 other heifers had evidence of embryonic death on PBD 40 and 42. Two control heifers inoculated with culture medium from noninfected cells maintained their pregnancies.
authors.affiliation: National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010.
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
authors.forename: M J
authors.initials: MJ
authors.lastname: Van der Maaten
authors.forename: C A
authors.initials: CA
authors.lastname: Whetstone
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology / Q000276:immunology; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology / Q000472:pathogenicity*; D007241:Infectious Bovine Rhinotracheitis / Q000150:complications* / Q000276:immunology; D007247:Infertility, Female / Q000209:etiology / Q000662:veterinary*; D011374:Progesterone / Q000097:blood; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D011374:Progesterone