title: An explanation of the stability of the incidence of inborn defects.
abstract: We propose a mathematical model for the malformation incidence in a population. The model is based on the assumption that malformations occur in a narrow range of embryotoxic doses for a given toxin and that this range varies in the population. Using this assumption, we exhibit malformation incidence curves which are in qualitative agreement with experimental data.
authors.affiliation: Institute of Physiology, Czechoslovak Academy of Sciences, Praha.
authors.forename: P
authors.initials: P
authors.lastname: Kůrka
authors.forename: R
authors.initials: R
authors.lastname: Jelínek
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D000013:Congenital Abnormalities / Q000453:epidemiology*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006801:Humans; D008954:Models, Biological; D011247:Pregnancy; D012984:Software; D013723:Teratogens / Q000633:toxicity*
chemical_list: D013723:Teratogens