Hypochlorite sensitivity in man.
Observation of an individual with immediate-type reaction following exaggerated dermal exposure to hypochlorite-containing cleaning products prompted review of similar hypersensitivity reactions attributed to hypochlorite or other highly reactive chemicals. This review confirms isolated incidences of hypochlorite sensitivity of the delayed type (allergic contact dermatitis), as well as immediate-type reactions from inhalation or topical challenge of sensitized individuals. We conclude that it is possible that excessive and prolonged exposure to hypochlorite may in some cases result in irritation and damage to the skin. This potentially gives rise to altered proteins which in rare cases may cause hypersensitivity. This reaction is common to other reactive small molecules with a strong irritant action.
Hostynek
J J
JJ
Department of Product Safety and Regulatory Compliance, Clorox Company, Pleasanton, CA 94566.
Patrick
E
E
Younger
B
B
Maibach
H I
HI
D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006795:Household Products / Q000009:adverse effects; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D006997:Hypochlorous Acid / Q000276:immunology*; D007509:Irritants / Q000009:adverse effects; D014581:Urticaria / Q000139:chemically induced* / Q000276:immunology
D007509:Irritants; D006997:Hypochlorous Acid