The major human rhinovirus receptor is ICAM-1.
The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhinovirus infection. These monoclonal antibodies recognize a 95 kd cell surface glycoprotein on human cells and on mouse transfectants expressing a rhinovirus binding phenotype. Purified 95 kd protein binds to rhinovirus in vitro. Protein sequence from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1 (ICAM-1); a cDNA clone obtained from mouse transfectants expressing the rhinovirus receptor had essentially the same sequence as ICAM-1. Thus, the major human rhinovirus receptor is ICAM-1. The gene for this receptor maps to human chromosome 19, which also contains the genes for a number of other picornavirus receptors.
Greve
J M
JM
Molecular Therapeutics, Inc., Miles Research Center, West Haven, Connecticut 06516.
Davis
G
G
Meyer
A M
AM
Forte
C P
CP
Yost
S C
SC
Marlor
C W
CW
Kamarck
M E
ME
McClelland
A
A
D000470:Alkaloids / Q000494:pharmacology; D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism*; D015815:Cell Adhesion Molecules; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011499:Protein Processing, Post-Translational; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D012229:Rhinovirus / Q000378:metabolism*; D017026:Swainsonine; D014162:Transfection; D014415:Tunicamycin / Q000494:pharmacology
D000470:Alkaloids; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D014415:Tunicamycin; D017026:Swainsonine