Production of epoxygenase metabolite by human reproductive tissues.
Human amnion, trophoblast and umbilical vein endothelial cells synthesise an arachidonic acid metabolite which is neither a lipoxygenase nor a cyclo-oxygenase product. It is sensitive to stimulants and inhibitors of the cytochrome-P450-dependent epoxygenase system and co-migrates on HPLC with 14,15-epoxyeicosatrienoic acid (14,15-EET), which is an epoxygenase product. The function of 14,15-EET in these reproductive tissues is unknown, but it may be involved in the maintenance of vascular function.
Patel
L
L
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Sullivan
M H
MH
Elder
M G
MG
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D001095:Arachidonic Acids / Q000378:metabolism; D001571:Benzoflavones / Q000494:pharmacology; D015237:Dinoprost / Q000378:metabolism; D004727:Endothelium / Q000166:cytology; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D014327:Trophoblasts / Q000201:enzymology*; D014471:Umbilical Veins / Q000378:metabolism*
D001095:Arachidonic Acids; D001571:Benzoflavones; D005231:Fatty Acids, Unsaturated; D006893:Hydroxyeicosatetraenoic Acids; D015121:6-Ketoprostaglandin F1 alpha; C011512:alpha-naphthoflavone; C046782:14,15-epoxy-5,8,11-eicosatrienoic acid; D015237:Dinoprost; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D015126:8,11,14-Eicosatrienoic Acid