title: Diagnosis of T-cell lymphoma using beta F1, anti-T-cell receptor beta chain antibody.
abstract: The reactivity of a new monoclonal antibody to the T-cell beta chain antigen receptor (beta F1) with routinely processed paraffin sections from patients with T-cell lymphoma is described. Staining of tumour cells was seen in 36/47 cases of T-cell lymphoma. No staining was seen in any cases of B-cell lymphoma (0/21 cases), nine of which had previously been shown to react with other T-cell antibodies (MT1/UCHL1). We conclude that beta F1 is a specific marker for demonstrating a T-cell histogenesis of lymphoma and with advantages over other currently available antibodies reactive with paraffin sections.
authors.affiliation: Department of Pathology, University Medical School, Edinburgh, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Krajewski
authors.forename: M W
authors.initials: MW
authors.lastname: Myskow
authors.forename: D M
authors.initials: DM
authors.lastname: Salter
authors.forename: D S
authors.initials: DS
authors.lastname: Cunningham
authors.forename: E F
authors.initials: EF
authors.lastname: Ramage
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta