[Protection of the monoamine oxidase in brain synaptosomes by fat- and water-soluble antioxidants during lipid peroxidation].
The protective effects of alpha-tocopherol, carnosine and their mixtures on monoamine oxidase activity, accumulation of lipid peroxidation products, lipid fatty acid composition, hydrophobicity and microviscosity of synaptic membranes during lipid peroxidation were studied. It was shown that the protective efficiency is more higher when the mixture of water and liposoluble antioxidants was used.
Antipov
A D
AD
Tiurin
V A
VA
Avrova
N F
NF
Khovanskikh
A E
AE
Kagan
V E
VE
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002336:Carnosine / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D012995:Solubility; D013574:Synaptosomes / Q000187:drug effects* / Q000201:enzymology; D014783:Viscosity; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D005296:Ferrous Compounds; D008563:Membrane Lipids; C051140:iron(II)-ascorbic acid complex; D014810:Vitamin E; D002336:Carnosine; D008995:Monoamine Oxidase; D001205:Ascorbic Acid
Zashchita monoaminoksidazy v sinaptosomakh mozga lipo- i vodorastvorimymi antioksidantami pri perekisnom okislenii lipidov.