[Statistical study of factors related to occurrence and progression of retinopathy in extremely premature infants: especially clinical changes in PaCO2 and pH].
Out of 39 premature infants admitted to the NICU in Toho University Hospital from January 1983 to December 1985 and surviving for 2 months after birth, 22 extremely premature infants who were closely matched in terms of gestational age and body weight at birth were divided into 4 groups (operated group, non-operated A group, non-operated B group and broncho-pulmonary dysplasia (BPD) group) to assess the effect of respiratory management on retinopathy of prematurity (ROP). ROP occurred at a high frequency in extremely premature infants weighing less than 1,000 g. In most of the infants who underwent operation (cryocauterization), PaCO2 values were low for 1 month after birth, whereas pH tended to rise. In the non-operated B group, PaCO2 was almost normal, and pH tended toward acidosis. BPD, which causes severe respiratory disturbance, was observed in 4 cases, 3 of whom showed a rise in PaCO2 within 1 month after birth, but mild ROP. Thus, it was considered that PaCO2 and pH exacerbated ROP.
Maeda
A
A
Tochikubo
T
T
Saito
N
N
Yano
T
T
Komoto
M
M
Uga
N
N
Fujii
T
T
D002245:Carbon Dioxide / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007234:Infant, Premature; D007564:Japan / Q000453:epidemiology; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012178:Retinopathy of Prematurity / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors
D002245:Carbon Dioxide; D010100:Oxygen