Circulating immune complexes in uveitis patients.
Immune complexes have been implicated in the pathogenesis of several types of uveitis. This has been substantiated in experimental models such as serum sickness, and in the analysis of the sera and aqueous of uveitis patients. The mechanisms influencing the deposition of the complexes in the eye are described. Furthermore a prospective study is presented, dealing with the presence of serum immune complexes and complement in 104 uveitis patients. A role for circulating immune complexes in the pathogenesis of uveitis could not be substantiated by this study.
Hylkema
H A
HA
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Kijlstra
A
A
D000936:Antigen-Antibody Complex / Q000097:blood*; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D008137:Longitudinal Studies; D011446:Prospective Studies; D014605:Uveitis / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003165:Complement System Proteins