title: Characterization of rearranged Y chromosomes in human testicular tumor cell lines.
abstract: Cytogenetic analysis of four cell lines established from two different human testicular tumors revealed rearranged or missing Y chromosomes. Southern blot analysis and in situ hybridization with different Y-derived human DNA sequences revealed the existence of Y chromosomal material even in a line without a cytogenetically visible Y chromosome and clarified the composition of Y marker chromosomes.
authors.affiliation: Institut für Humangenetik, Universitätskliniken, Göttingen, West Germany.
authors.forename: J
authors.initials: J
authors.lastname: Arnemann
authors.forename: G
authors.initials: G
authors.lastname: Gradl
authors.forename: J
authors.initials: J
authors.lastname: Casper
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmoll
authors.forename: J
authors.initials: J
authors.lastname: Schmidtke
authors.forename: C
authors.initials: C
authors.lastname: Fonatsch
mesh_terms: D001483:Base Sequence; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013736:Testicular Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured; D014998:Y Chromosome
chemical_list: D004273:DNA, Neoplasm