title: Atrial natriuretic factor suppresses M-current in frog but not in rat sympathetic neurones.
abstract: The effects of atrial natriuretic factor (ANF) were investigated on rat and bullfrog sympathetic ganglia. Although there was little effect on neurones from rat superior cervical ganglion (SCG), B-cells in bullfrog paravertebral ganglia (BFSG) were depolarized. This depolarization was often associated with an increase in excitability and suppression of a voltage-dependent K+ current, the M-current (IM). ANF did not affect the amplitude of the nicotinic EPSP in either ganglion.
authors.affiliation: Department of Pharmacology, University of Alberta, Edmonton, Alta., Canada.
authors.forename: K K
authors.initials: KK
authors.lastname: Pant
authors.forename: P A
authors.initials: PA
authors.lastname: Smith
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011892:Rana catesbeiana / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: C472610:atrial natriuretic peptide, rat; D009320:Atrial Natriuretic Factor