Thyroid antigen-mediated glomerulonephritis in Graves' disease.
We describe a patient with Graves' disease in whom marked proteinuria, microhematuria and hypoalbuminemia were associated. Renal biopsy demonstrated electrondense deposits in the capillary basement membrane, a finding consistent with immune complex glomerulonephritis. Indirect immunofluorescent examination with rabbit antihuman thyroglobulin indicated that these electron-dense deposits were thyroid antigen-mediated immune complexes.
Sato
Y
Y
Surugadai Nihon University Hospital, Department of Cardiology, Tokyo, Japan.
Sasaki
M
M
Kan
R
R
Osaku
A
A
Koyama
S
S
Shibayama
S
S
Sato
M
M
Narumiya
K
K
Takagi
T
T
Kojima
M
M
D000936:Antigen-Antibody Complex / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D015433:Glomerulonephritis, Membranous / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001324:Autoantigens; D013954:Thyroglobulin