title: [Efficacy and tolerability of cefixime in lower respiratory tract infections in adults. French multicentric study].
abstract: Cefixime is a new oral cephalosporin with the same activity as that of third generation cephalosporins, particularly against organisms responsible for lower respiratory tract infections. The effectiveness and safety of cefixime were evaluated in the multicentre study reported here. Cure was obtained in 54 of 61 assessable patients suffering from bronchopneumonia (40/44), acute bronchitis (3/5) or acute exacerbations of chronic bronchitis (11/12). The causative agents were eradicated in 35 of 41 assessable cases. No clinical side-effect was observed. Thrombocytosis without clinical manifestations was reported in 14 cases. Administered in doses of 200 mg twice daily, cefixime proved effective and safe in the treatment of lower respiratory tract infections.
authors.affiliation: Clinique des Maladies infectieuses, Hôpital Saint-Louis, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Modai
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020682:Cefixime; D002439:Cefotaxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000209:etiology
chemical_list: D020682:Cefixime; D002439:Cefotaxime
vernacular_title: Efficacité et tolérance du céfixime dans les infections respiratoires basses de l'adulte. Etude multicentrique française.