[Analysis of the diagnostic significance of various immunologic indicators in children with primary glomerulonephritis].
A study was made of the immunogenetic parameters--the physicochemical properties of the circulating immune complexes (CIC) and their interrelation with HLA antigens--in 70 children aged 1 to 15 years with primary acquired glomerulonephritis (PGN). It has been demonstrated that the active period of PGN is characterized by high conceptration of the CIC of medium size (molecular mass) in children with HLA antigens. This characterizes the predisposition of the persons with the established phenotype to PGN as well as evidences that CIC play an undoubtful role in the pathogenesis of autosensitization in PGN.
Reznik
B Ia
BIa
Podgornaia
T G
TG
Minkov
I P
IP
Abakumova
A D
AD
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000276:immunology; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D007105:Immune Complex Diseases / Q000175:diagnosis* / Q000276:immunology; D007223:Infant; D008297:Male
D000936:Antigen-Antibody Complex; D015234:HLA-A Antigens; D015235:HLA-B Antigens
Analiz diagnosticheskoĭ znachimosti nekotorykh immunologicheskikh pokazateleĭ pri pervichnom glomerulonefrite u deteĭ.