title: Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms.
abstract: O-Acetyl-L-homoserine sulfhydrylase (EC 4.2.99.10) is essential for certain micro-organisms, functioning as a homocysteine synthase in the pathway of methionine synthesis. It participates in an alternative pathway of L-homocysteine synthesis for those microbes in which homocysteine is synthesized mainly via cystathionine. The protein can also catalyze the de novo synthesis of L-cysteine and O-alkyl-L-homoserine in some microorganisms. The enzyme possibly recycles the methylthio group of methionine.
authors.affiliation: Department of Biology, Faculty of General Education, Gifu University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamagata
mesh_terms: D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D019757:Carbon-Oxygen Lyases; D003547:Cysteine Synthase; D005658:Fungi / Q000201:enzymology* / Q000235:genetics; D008190:Lyases / Q000235:genetics / Q000378:metabolism; D008970:Molecular Weight; D009097:Multienzyme Complexes; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D009097:Multienzyme Complexes; D029701:Saccharomyces cerevisiae Proteins; D003547:Cysteine Synthase; C103381:MET17 protein, S cerevisiae; C018725:O-acetylhomoserine (thiol)-lyase; D008190:Lyases; D019757:Carbon-Oxygen Lyases