Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits.
1. It has been suggested that beta 2-adrenoreceptors in skeletal muscle regulate plasma potassium. The possibility that alterations in the function and/or density of these receptors occurs in perinephritis hypertension in rabbits was studied. 2. Intravenous infusion of adrenaline (0.2 micrograms kg-1 min-1) caused a fall in potassium while intravenous bolus injection of propranolol (0.75 mg kg-1) resulted in an increase in serum potassium which was of similar magnitude in both perinephritis hypertensive and sham-operated normotensive rabbits. 3. Binding studies with the radioligand [125I] cyanopindolol (ICYP) showed that there were no significant differences between the hypertensive and normotensive rabbits in the density (Bmax) or affinity (KD) of the skeletal muscle beta 2-adrenoreceptor. 4. The results suggest that function and density of skeletal muscle beta 2-adrenoreceptors are not altered in rabbits with perinephritis hypertension.
Elfellah
M S
MS
Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
Hamilton
C A
CA
McIntosh
W
W
Barr
S M
SM
Howie
C
C
Reid
J L
JL
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006977:Hypertension, Renal / Q000097:blood / Q000378:metabolism*; D007457:Iodine Radioisotopes; D020120:Iodocyanopindolol; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010501:Perinephritis / Q000150:complications*; D010869:Pindolol / Q000031:analogs & derivatives; D011188:Potassium / Q000097:blood*; D011817:Rabbits; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D020120:Iodocyanopindolol; D010869:Pindolol; D011188:Potassium; D004837:Epinephrine