V beta-specific stimulation of human T cells by staphylococcal toxins.
The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.
Kappler
J
J
Howard Hughes Medical Institute, Denver, CO.
Kotzin
B
B
Herron
L
L
Gelfand
E W
EW
Bigler
R D
RD
Boylston
A
A
Carrel
S
S
Posnett
D N
DN
Choi
Y
Y
Marrack
P
P
D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001427:Bacterial Toxins / Q000276:immunology / Q000494:pharmacology*; D017252:CD3 Complex; D016827:CD8 Antigens; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000276:immunology*; D013210:Staphylococcus; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte; D001427:Bacterial Toxins; D017252:CD3 Complex; D016827:CD8 Antigens; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell