title: [Circadian variations in the production of superoxide and liberation of lysosomal enzymes of neutrophils in peripheral blood].
abstract: Superoxide formation and lysosomal enzyme liberation circulating neutrophils has been assessed in healthy subjects. Blood samples were obtained at 8:00, 14:00, and 20:00 o'clock. The formation of superoxide followed a circadian rythm. Lowest concentration was found a 14:00 hours (4.59 +/- 2.09 nM reduced cytochrome/10(6) neutrophils). No 24 hour variation of betaglucuronidase and lysozyme liberation was proven. The number of neutrophil receptors for formyl-methyonil-leucyl-phenyl-alamine (FMLP) at the same hours did not show any circadian variation. The circadian changes of the functional capacity of the neutrophils might be one of the mechanisms that could justify the 24 hour variation of symptomatology characteristic of some diseases.
authors.forename: M A
authors.initials: MA
authors.lastname: Muniain
authors.forename: M D
authors.initials: MD
authors.lastname: Rodríguez
authors.forename: R
authors.initials: R
authors.lastname: Mata
authors.forename: F
authors.initials: F
authors.lastname: Pozuelo
authors.forename: M J
authors.initials: MJ
authors.lastname: Giménez
authors.forename: A
authors.initials: A
authors.lastname: Romero
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D004789:Enzyme Activation; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009113:Muramidase / Q000097:blood*; D009504:Neutrophils / Q000201:enzymology*; D013481:Superoxides / Q000096:biosynthesis / Q000097:blood*
chemical_list: D013481:Superoxides; D009113:Muramidase
vernacular_title: Variaciones circadianas en la producción de superóxido y liberación de enzimas lisosómicas por los neutrófilos de sangre periférica.