Hematologic effects of short-term oral diethylcarbamazine treatment given to chronically feline leukemia virus-infected cats.
Diethylcarbamazine (N,N-diethyl-4-methyl-1-piperazine carboxamide [DEC]) is widely used, especially in tropical regions, to prevent and treat filariasis. The antifilarial effect of this drug has been attributed to immunomodulation. Evidence is accumulating to indicate that DEC may mitigate the course of feline leukemia virus infection (FeLV) in cats. Previous studies have suggested that continuous oral DEC treatment given shortly after evidence of FeLV infection prevents or delays lymphopenia and prolongs survival. The present study focuses on the hematologic effects of one month oral DEC treatment given to adult chronically FeLV-infected cats and uninfected cats as compared to untreated FeLV-infected cats. Such treatment frequently resulted in abruptly lowered peripheral lymphocyte counts in chronically FeLV-infected cats. Further studies are warranted to evaluate whether administration of DEC could eliminate circulating retroviral-infected cells.
Kitchen
L W
LW
Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.
Mather
F J
FJ
D000276:Adjuvants, Immunologic; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001772:Blood Cell Count; D002415:Cats; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D006400:Hematocrit; D005256:Leukemia Virus, Feline / Q000276:immunology; D007942:Leukemia, Experimental / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D007958:Leukocyte Count; D008214:Lymphocytes; D008231:Lymphopenia / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D004049:Diethylcarbamazine