Alteration of kainic acid and quinolinic acid toxicity by neostriatal transplants in vitro.
Mature (greater than 21 days in vitro) organotypic corticostriatal cultures prepared from newborn rat brain were incubated in either kainic acid (KA) 10(-3) M or quinolinic acid (QUIN) 10(-3) M for up to 48 h. Other identical cultures were similarly incubated immediately after they had received one or two additional explants of neonatal striatal tissue placed beside each corticostriatal culture. The cultures incubated with either KA or QUIN in the presence of the neonatal striatal tissue showed better preservation than cultures incubated with KA or QUIN alone. Results suggest that the neonatal striatal explants or 'transplants' afford some protective effect against the toxicity or either KA or QUIN.
Whetsell
W O
WO
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Allen
G S
GS
Tulipan
N B
NB
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007608:Kainic Acid / Q000633:toxicity*; D008854:Microscopy, Electron; D011725:Pyridines / Q000633:toxicity*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity*; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000648:ultrastructure
D011725:Pyridines; D011805:Quinolinic Acids; D017378:Quinolinic Acid; D007608:Kainic Acid