Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives.
The synthesis of a series of 4-phenylquinolines with substituents in 2,3 and 6-position of the quinoline nucleus is described. Serotoninergic activity towards 5HT1A, 5HT1B, 5HT2, 5HT1A + B receptors and the 5-HT-uptake site was also studied.
Anzini
M
M
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.
Vomero
S
S
Garofalo
A
A
Cappelli
A
A
Cagnotto
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017374:Paroxetine; D010880:Piperidines; D011804:Quinolines / Q000138:chemical synthesis*; D011814:Quipazine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists; D013569:Synapses / Q000378:metabolism
D010880:Piperidines; D011804:Quinolines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017374:Paroxetine; D011814:Quipazine