Factors influencing pertechnetate uptake by rabbit knees.
The accumulation of radioactivity over rabbit knees immediately after the injection of 99mTc-pertechnetate or one of two 99mTc-labelled particulate preparations has been measured in animals with and without experimental arthritis. The results indicate that in inflamed, but not normal joints, a peak of radioactivity is detectable within 9 seconds of injection and suggest that the rate of accumulation of radioactivity over the joint may be a more sensitive indicator of inflammatory activity than measurement at a fixed time. Clearance from the circulation and tissue distribution of the three radioactive preparations were also measured.
Bard
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Strangeways Research Laboratory, Cambridge.
Page-Thomas
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D000818:Animals; D001168:Arthritis / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007719:Knee Joint / Q000378:metabolism*; D008863:Microspheres; D011817:Rabbits; D012016:Reference Values; D013670:Sodium Pertechnetate Tc 99m / Q000097:blood / Q000493:pharmacokinetics*; D013667:Technetium / Q000097:blood; D013997:Time Factors; D014018:Tissue Distribution
D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m