Testing of nucleoside analogues in cats infected with feline leukemia virus: a model.
In the present communication we evaluate the feline leukemia virus (FeLV) infection of cats as a model for antiretroviral chemotherapy studies. Additionally, we report the results of testing the antiviral effect of the compounds, 3'-azido-3'-deoxythymidine (AZT), 2',3'-dideoxycytidine, 2',3'-dideoxyinosine and 2',3'-dideoxyadenosine against FeLV replication in vitro. Cumulative data from experiments in which FeLV-infected cats were treated with AZT at different stages of experimental infection are also evaluated.
Tavares
L
L
Department of Veterinary Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Roneker
C
C
Postie
L
L
de Noronha
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D002415:Cats; D002460:Cell Line; D016049:Didanosine; D016048:Dideoxyadenosine; D015224:Dideoxynucleosides / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D005256:Leukemia Virus, Feline / Q000187:drug effects / Q000502:physiology; D007942:Leukemia, Experimental / Q000188:drug therapy; D009705:Nucleosides / Q000494:pharmacology / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms; D014779:Virus Replication / Q000187:drug effects; D016047:Zalcitabine; D015215:Zidovudine / Q000494:pharmacology / Q000627:therapeutic use
D000914:Antibodies, Viral; D000998:Antiviral Agents; D015224:Dideoxynucleosides; D009705:Nucleosides; D015215:Zidovudine; D016048:Dideoxyadenosine; D016047:Zalcitabine; D016049:Didanosine