Retention enhancement with post-training picrotoxin: lack of state dependency.
Immediate post-training intraperitoneal administration of the GABA-antagonist picrotoxin (0.5 or 1.0 mg/kg) significantly enhanced retention of CD1 mice tested 24 h after training in an inhibitory avoidance task. Administration of picrotoxin prior to the retention test did not affect the retention performance of mice given post-training injections of either saline or picrotoxin. These findings indicate that the memory-enhancing effects of post-training administration of picrotoxin are not state-dependent.
Castellano
C
C
Instituto di Psicobiologia e Psicofarmacologia del CNR, Roma, Italy.
McGaugh
J L
JL
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D010852:Picrotoxin / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects*
D010852:Picrotoxin; D011963:Receptors, GABA-A