[Photosensitized inactivation of HeLa tumor cells by phthalocyanines].
The combined effect of tetrasulfonated phthalocyanine (TSPC, 1.0 microM) or chloroaluminum phthalocyanine (CAPC, 1.0 microM) and copper vapour laser radiation (lambda = 670 nm) causes a dose dependent decrease in the survival rate of HeLa cells at exponential and stationary growth phases estimated by the trypan blue exclusion test or colony-forming ability test. TSPC is two times and CAPC seven times more effective, with regard to lethality, than the known photosensitizer, a hematoporphyrin derivative.
Karu
T I
TI
Piatibrat
L V
LV
Kalenko
G S
GS
D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells / Q000187:drug effects*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D054833:Isoindoles; D007834:Lasers; D009942:Organometallic Compounds / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D006415:Hematoporphyrins; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C044797:chloroaluminum phthalocyanine; C028418:tetrasulfophthalocyanine; D017324:Hematoporphyrin Derivative; C013647:phthalocyanine
Fotosensibilizirovannaia inaktivatsiia opukholevykh kletok HeLa ftalotsianinami.