[Establishment and characterization of five human myeloma cell lines].
Since 1980 five human myeloma cell lines, KMM-1, KMS-5, KMS-11, KMS-12-PE and KMS-12-BM, have been established in Kawasaki Medical School. Histologically, all the cell lines resembled plasma cells and were EBNA negative. KMM-1, KMS-11, KMS-12-PE and KMS-12-BM reacted with PCA-1, while KMM-1, KMS-12-PE and KMS-12-BM with CD38. KMM-1 and KMS-11 secreted immunoglobulins into culture medium. Karyologically, all the cell lines were abnormal. Only KMS-5 was tumorigenic when transplanted subcutaneously into nude mice.
Ohtsuki
T
T
Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.
Yawata
Y
Y
Namba
M
M
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002455:Cell Division; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007621:Karyotyping; D008297:Male; D051379:Mice; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000473:pathology*
D014408:Biomarkers, Tumor; D007136:Immunoglobulins