title: Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.
abstract: In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: C D
authors.initials: CD
authors.lastname: Blackstone
authors.forename: S
authors.initials: S
authors.lastname: Supattapone
authors.forename: S H
authors.initials: SH
authors.lastname: Snyder
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002122:Calcium Chloride / Q000494:pharmacology; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D005971:Glutamates / Q000502:physiology*; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008297:Male; D010069:Oxadiazoles / Q000494:pharmacology; D011689:Purkinje Cells / Q000502:physiology*; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013403:Sugar Phosphates / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D005971:Glutamates; D007295:Inositol Phosphates; D010069:Oxadiazoles; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D013403:Sugar Phosphates; D004533:Egtazic Acid; D016318:Quisqualic Acid; D002122:Calcium Chloride