Type I diabetes in an adolescent with common variable immunodeficiency.
A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The patient's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.
Moffitt
J E
JE
Medical College of Georgia, Augusta 30912.
Guill
M F
MF
Leffell
M S
MS
Ades
E W
EW
Burek
C L
CL
Lobel
S A
SA
Hoffman
W H
WH
D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications / Q000276:immunology; D000917:Antibody Formation; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D012008:Recurrence; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen