title: Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.
abstract: The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.
authors.affiliation: National Eye Institute, Bethesda, MD 20892.
authors.forename: M B
authors.initials: MB
authors.lastname: Datiles
authors.forename: H
authors.initials: H
authors.lastname: Fukui
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology; D004195:Disease Models, Animal; D007093:Imidazoles / Q000627:therapeutic use*; D048289:Imidazolidines; D007908:Lens, Crystalline / Q000473:pathology; D012377:Rodentia / Q000502:physiology*; D013311:Streptozocin; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
chemical_list: D007093:Imidazoles; D048289:Imidazolidines; D013311:Streptozocin; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; C026411:sorbinil