title: Movement of microtubules by single kinesin molecules.
abstract: Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles along microtubules. Using a new technique for measuring the movement produced in vitro by individual kinesin molecules, it is shown that a single kinesin molecule can move a microtubule for several micrometers. New information about the mechanism of force generation by kinesin is presented.
authors.affiliation: Department of Physiology, University of California School of Medicine, San Francisco.
authors.forename: J
authors.initials: J
authors.lastname: Howard
authors.forename: A J
authors.initials: AJ
authors.lastname: Hudspeth
authors.forename: R D
authors.initials: RD
authors.lastname: Vale
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002465:Cell Movement; D002474:Cell-Free System; D066298:In Vitro Techniques; D016547:Kinesins; D008868:Microtubule Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D014741:Video Recording
chemical_list: D008868:Microtubule Proteins; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D016547:Kinesins