Simultaneous analysis of skin response to the different L.E.T. regions of a 55 MeV helium ion beam.
Rat tail epidermis was used to analyze the in vivo response of a biological system to heavy particle irradiation. The conical configuration of the rat tail gives rise to a variable energy degradation of the beam thus yielding information on the damage elicited by 2 different L.E.T. regions of the helium beam at different sites on the same sample. Cytochrome oxidase activity and epidermal thickness were used to analyze the metabolic and structural radioinduced response. Quantitative evaluation of radiation damage revealed marked variations within a few micrometers of tissue.
Schwint
A E
AE
Radiobiology Department, National Atomic Energy Commission, Buenos Aires, Argentina.
de Rey
B M
BM
Bernaola
O A
OA
Mazzei
R
R
Itoiz
M E
ME
D000512:Alpha Particles; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D003576:Electron Transport Complex IV / Q000378:metabolism; D004735:Energy Transfer; D006371:Helium; D011833:Radiation Injuries, Experimental / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*
D006371:Helium; D003576:Electron Transport Complex IV