title: Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
abstract: The present findings show clearly that valproic acid, carbamazepine and phenytoin are each capable of significantly raising serum aspirin-esterase activity in epileptics being treated with these drugs (between p less than 0.01 and p less than 0.05). The data suggest that these antiepileptic drugs may well act as enzymatic-inducing agents upon plasma cholinesterase (or pseudocholinesterase) in epileptic patients.
authors.affiliation: Clinical Pharmacology Unit, University of Granada Hospital, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Puche
authors.forename: M
authors.initials: M
authors.lastname: Garcia Morillas
authors.forename: H
authors.initials: H
authors.lastname: Garcia de la Serrana
authors.forename: C
authors.initials: C
authors.lastname: Mota
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002220:Carbamazepine / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase; D002802:Cholinesterases