title: Effect of intraventricular nadolol infusion on shock-induced aggression in 6-hydroxydopamine-treated rats.
abstract: Increasingly, beta blockers are being utilized to treat patients with aggressive disorders secondary to brain lesions. To secure further data about the potential efficacy of beta blockers for this condition, a rat model was employed in which aggression was enhanced by 6-hydroxydopamine. Following lesioning of the brain, aggression in the rats increased from an average baseline of 10.9 +/- 2.1 to 42.7 +/- 2.0 fights per testing period. Thereafter, either pharmacologically inert, artificial CSF or nadolol was introduced through transcerebral, intraventricular perfusion with a significant reduction in aggression in the nadolol-treated animals when compared with those receiving artificial CSF.
authors.affiliation: Department of Neuroscience Research, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212.
authors.forename: M L
authors.initials: ML
authors.lastname: Leavitt
authors.forename: S C
authors.initials: SC
authors.lastname: Yudofsky
authors.forename: J C
authors.initials: JC
authors.lastname: Maroon
authors.forename: E J
authors.initials: EJ
authors.lastname: Riley
authors.forename: M B
authors.initials: MB
authors.lastname: Bavitz
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D007276:Injections, Intraventricular; D008297:Male; D009248:Nadolol / Q000494:pharmacology*; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009248:Nadolol; D016627:Oxidopamine