Antitumor activity of orally administered streptococcal preparation, OK-432 on murine solid tumors and its absorption from the gut.
OK-432 is an immunopotentiator which is normally administered by injection. In the present study, the antitumor activity of orally administered OK-432 on various solid tumors and the absorption of OK-432 from the gut were studied. Orally administered OK-432 inhibited the growth of Meth-A and BAMC-1 fibrosarcomas which had been subcutaneously transplanted in BALB/c mice. Autoradiograms of mice which had been administered 14C-labelled OK-432 orally demonstrated the absorption of OK-432 from the gut, and about 6% of orally administered OK-432 was absorbed 24 hrs after its administration. Moreover, an immunofluorescent study using an anti-OK-432 antibody revealed specific fluorescence in the mesenteric lymph node of mice which had been orally administered with OK-432. These results suggest that oral administration of OK-432 may be a beneficial immunotherapy.
Nio
Y
Y
Division of Surgical Oncology, Kyoto University Faculty of Medicine, Japan.
Shiraishi
T
T
Tsuchitani
T
T
Tobe
T
T
Sugawara
Y
Y
Saito
M
M
Kamiyama
H
H
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D005354:Fibrosarcoma / Q000188:drug therapy*; D005455:Fluorescent Antibody Technique; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010844:Picibanil / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D010844:Picibanil