R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade, combined in one molecule.
De Clerck
F
F
Department of Haematol, Janssen Research Foundation, Beerse, Belgium.
Beetens
J
J
de Chaffoy de Courcelles
D
D
Vercammen
E
E
Freyne
E
E
Janssen
P A
PA
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D010421:Pentanoic Acids / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011449:Prostaglandin Endoperoxides / Q000097:blood; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011982:Receptors, Prostaglandin / Q000378:metabolism; D017482:Receptors, Thromboxane; D013928:Thromboxane A2 / Q000097:blood; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014631:Valerates / Q000494:pharmacology*
D001095:Arachidonic Acids; D010421:Pentanoic Acids; D011449:Prostaglandin Endoperoxides; D011725:Pyridines; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D014631:Valerates; D016718:Arachidonic Acid; D013928:Thromboxane A2; D013930:Thromboxane-A Synthase; C060219:ridogrel