Ca2+ channel blockers prevent seizures induced by a class of K+ channel inhibitors.
Intracerebroventricular injection into rats of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), three blockers of a subclass of K+ channels, elicited epileptiform wave bursts and convulsions. Three different types of L-type Ca2+ channel inhibitors (+)PN 200-110, a 1,4-dihydropyridine, (-)D888, a phenylalkylamine, and fluspirilene, a diphenylbutylpiperidine, were potent blockers of the convulsant-induced hyperexcitatory effects when they were administered preventively. D-AP5, a N-methyl-D-aspartate antagonist, was active on the 4-AP-induced seizures but was without effect on the MCD- and dendrotoxin-induced seizures.
Gandolfo
G
G
Laboratoire de Psychophysiologie, Faculté des Sciences et Techniques, Nice, France.
Gottesmann
C
C
Bidard
J N
JN
Lazdunski
M
M
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004546:Elapid Venoms / Q000494:pharmacology; D004562:Electrocardiography; D006624:Hippocampus / Q000502:physiology; D007457:Iodine Radioisotopes; D008297:Male; D010455:Peptides / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D004546:Elapid Venoms; D007457:Iodine Radioisotopes; D010455:Peptides; D015221:Potassium Channels; C008331:mast cell degranulating peptide; C020273:dendrotoxin; D015761:4-Aminopyridine