[Anticarcinogenesis activity of natural carotenes].
Natural carotene sample obtained from palm oil was proved to suppress the promoting stage of two-stage carcinogenesis of mouse skin, and also inhibit the proliferation of human malignant tumor cells, such as neuroblastoma GOTO cells, stomach cancer HGC-27 cells, and pancreatic cancer PANC-I cells. Among the major constituents of palm carotene, alpha-carotene showed stronger anti-proliferative effect than beta-carotene. The present results indicate that further investigation for not only beta-carotene but also other kinds of natural carotenes, such as alpha-carotene, should be carried out.
Nishino
H
H
Département de Biochimie, Université Médicale de la Préfecture de Kyoto, Japon.
Takayasu
J
J
Iwashima
A
A
Murakoshi
M
M
Imanishi
J
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D002338:Carotenoids / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D010938:Plant Oils; D002338:Carotenoids
Activité anticarcinogénétique des carotènes naturels.