Effects of acute reperfusion on regional myocardial function: serial two-dimensional echocardiography assessment.
Serial two-dimensional echocardiography was performed in 23 patients with acute myocardial infarction who received intravenous thrombolytic therapy to evaluate the effect of acute reperfusion on regional wall motion abnormalities. Regional wall motion abnormalities improved in 4 of the 14 patients (29%) with successful reperfusion and in 1 of the 9 (11%) without successful reperfusion. In successfully reperfused patients, the main determinant of improvement in regional wall motion abnormalities was duration from the onset of chest pain to the time of reperfusion (3.3 vs. 6.3 h in successfully reperfused patients without recovery of regional wall motion abnormalities; P less than 0.001).
Oh
J K
JK
Division of Cardivascular Diseases and Internal Medicine, Mayo Clinic, Rochester 55905.
Gersh
B J
BJ
Nassef
L A
LA
Miller
F A
FA
Chesebro
J H
JH
Holmes
D R
DR
Smith
H C
HC
Tajik
A J
AJ
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D002302:Cardiac Output / Q000187:drug effects; D015150:Echocardiography, Doppler; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*
D005343:Fibrinolytic Agents