title: Suppression of antigraft immunity by preimmunization. V. Characterization of suppressor T memory cells.
abstract: We have previously shown that after intravenous (i.v.) immunization of mice with allogeneic spleen cells, two populations of suppressor T (Ts) cells may occur that can suppress delayed-type hypersensitivity (DTH) to alloantigens: Ts effector cells that transiently occur in the spleen, and long-lived, recirculating Ts cells that occur in thoracic duct lymph and can be transferred by parabiosis. In this study, we investigated whether the latter Ts cells fulfill the criteria for memory T lymphocytes, such as induction by doses of antigen lower than required for T effector cell induction, accelerated onset of activity after reactivation and an increased activity as compared with virgin T cells. The Ts cells accounting for the long-lasting state of suppression of DTH to alloantigens indeed fulfilled these criteria. These Ts memory cells displayed the Thy-1+, L3T4-, Lyt-1+2+ phenotype.
authors.affiliation: Department of Cell Biology, Immunology and Genetics, Erasmus University, Rotterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Molendijk
authors.forename: L M
authors.initials: LM
authors.lastname: Hussaarts-Odijk
authors.forename: R J
authors.initials: RJ
authors.lastname: van Gurp
authors.forename: H
authors.initials: H
authors.lastname: de Ruiter
authors.forename: R
authors.initials: R
authors.lastname: Benner
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D005260:Female; D006082:Graft Enhancement, Immunologic; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D007114:Immunization; D007156:Immunologic Memory; D007519:Isoantigens / Q000276:immunology; D008196:Lymph / Q000166:cytology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D010227:Parabiosis; D013154:Spleen / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000637:transplantation
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D007519:Isoantigens