Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21.
The expression of the ETS-2 proto-oncogene, located on chromosome 21, in normal fetal tissues and in neural tissue of a fetus affected by Down syndrome has been investigated. The results show that the ETS-2 proto-oncogene is expressed in almost all the tissues examined and that it is transcribed at constant levels in neural tissue between the 13th and 24th weeks. ETS-2 expression appeared to be slightly increased in Down syndrome brain compared with that of normal controls of the same gestational age.
Baffico
M
M
Divisione di Pediatria, Centro Studi Regionale Sindrome di Down, Genova, Italy.
Perroni
L
L
Rasore-Quartino
A
A
Scartezzini
P
P
D001921:Brain / Q000196:embryology; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics*; D005333:Fetus; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes
D005819:Genetic Markers; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas