title: Disseminated echovirus infection in a patient with multiple myeloma and a functional defect in complement. Treatment with intravenous immunoglobulin.
abstract: A man with IgG1 multiple myeloma developed fever, confusion, and progressive muscle weakness resulting in paralysis. Echovirus type 11 was isolated from cerebrospinal fluid, pleura, pleural fluid, and muscle, and muscle biopsy disclosed changes consistent with viral myositis. Immunologic evaluation revealed low serum levels of polyclonal IgG subtypes 1 and 3, reduced blood levels of T-helper/inducer and T-suppressor/cytotoxic cells, and a complement abnormality involving the function of the classical pathway C3 convertase, C4b2a. Therapy with intravenous immunoglobulin was associated with clinical recovery. This is the first reported case of disseminated central nervous system enteroviral infection in an adult with a B-cell malignancy, and in association with a documented complement abnormality. The findings suggest the efficacy of immunotherapy in this disease.
authors.affiliation: Divisions of Immunology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.
authors.forename: J K
authors.initials: JK
authors.lastname: Smith
authors.forename: D S
authors.initials: DS
authors.lastname: Chi
authors.forename: J
authors.initials: J
authors.lastname: Guarderas
authors.forename: P
authors.initials: P
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Verghese
authors.forename: S L
authors.initials: SL
authors.lastname: Berk
mesh_terms: D003167:Complement Activation; D004457:Echovirus Infections / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D004660:Encephalitis / Q000209:etiology; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D009220:Myositis / Q000209:etiology; D013601:T-Lymphocytes; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
chemical_list: D007074:Immunoglobulin G