[Modeling of the "universal" bone marrow using monoclonal antibodies].
The data on the application of monoclonal antibodies (ICO-10) and rabbit complement for working the conditions of allogeneic bone marrow transplantation are presented in the paper. The treatment with monoclonal antibodies and bone marrow complement from BALB/c mice for 2 times prevented the development of transplant versus host reaction and completely protected lethally irradiated (CBA X X C57B1/6)FI mice-recipients from death. Thymus atrophy and the absence of T-cells in the peripheral blood was observed in these mice. The erythrocytes had markers characteristic of BALB/c and (CBA X C57B1/6)FI mice. Mouse splenocytes did not respond to the cells of donors and recipients in mixed lymphocyte culture reaction.
Chimishkian
K L
KL
Baryshnikov
A Iu
AIu
Ovumian
G Sh
GSh
Kostrykina
V N
VN
Karpov
I A
IA
Buntsevich
A M
AM
Slavina
E G
EG
Udalov
G A
GA
Kadagidze
Z G
ZG
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003165:Complement System Proteins / Q000627:therapeutic use; D006087:Graft vs Host Reaction; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D003165:Complement System Proteins
Modelirovanie "universal'nogo" kostnogo mozga s pomoshch'iu monoklonal'nykh antitel.