Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate.
Isopropyl methanesulfonate (IMS), a direct-acting SN1 alkylating agent, induced thymic lymphomas in 29 of 30 female Hsd: (ICR)BR mice by the 139th day following once a week subcutaneous injections at a dose of 10 mumol/mouse. No such neoplasms were observed at the 450th day following 52 once a week subcutaneous injections (20 mumol/mouse) of the borderline SN1/SN2 alkylating agent ethyl methanesulfonate (EMS). Local sarcomas were observed in 2 and pulmonary adenomas in 20 of the 30 EMS-treated mice, 70% of which were alive at the 450th day. Neoplasms were not observed at local or at distant sites other than the thymus gland following treatment with IMS. The results suggest a sensitivity of hemopoietic tissue to the types of DNA lesions induced by IMS.
Segal
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Department of Environmental Medicine, New York University School of Medicine, New York 10016.
Sellakumar
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D000818:Animals; D004247:DNA / Q000378:metabolism; D005020:Ethyl Methanesulfonate / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D007279:Injections, Subcutaneous; D008223:Lymphoma / Q000139:chemically induced*; D008698:Mesylates / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D013953:Thymus Neoplasms / Q000139:chemically induced*
D008698:Mesylates; D004247:DNA; D005020:Ethyl Methanesulfonate; C002531:isopropylmethanesulfonate