title: Sensorineural hearing loss in antigen-induced otitis media.
abstract: Chinchillas were sensitized with human serum albumin (HSA). When circulating antibody-titers were sufficiently elevated as to induce local inflammation, 1 ml of HSA (50, 5, 0.5 mg/ml) was instilled into the left middle ear cavity from the superior bulla. HSA containing a steroid agent was instilled into the right ear. Non-sensitized animals were used as control. In the sensitized animals, a significant hearing loss occurred at higher frequencies. The loss was dose-related. Less severe hearing loss was found following steroid treatment. We conclude that sensorineural hearing loss can occur in antigen-induced otitis media.
authors.affiliation: Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
authors.forename: T
authors.initials: T
authors.lastname: Morizono
authors.forename: Y
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: S K
authors.initials: SK
authors.lastname: Juhn
mesh_terms: D000818:Animals; D001183:Arthus Reaction / Q000276:immunology; D002682:Chinchilla; D003051:Cochlea / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D010033:Otitis Media / Q000150:complications* / Q000209:etiology; D012709:Serum Albumin / Q000276:immunology
chemical_list: D012709:Serum Albumin