Effect of plasmin inhibitors on gastric mucosal permeability in rats.
We examined the protective effect of plasmin inhibitors on gastric mucosal vascular permeability in rats. Tranexamic acid and aminocaproic acid significantly inhibited the increase in vascular permeability and macroscopic gastric mucosal lesions induced by 50% ethanol and 1% ammonia. The protective effect afforded by plasmin inhibitors was not affected by pretreatment with indomethacin. Our results show that plasmin inhibitors inhibit the increase in gastric vascular permeability and suggest that plasmin may play an important role in the pathogenesis of gastric mucosal damage.
Yoo
J K
JK
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Murakami
M
M
Teramura
S
S
Saita
H
H
Kusaka
S
S
Matsuo
K
K
Kita
T
T
Miyake
T
T
D000614:Aminocaproates / Q000494:pharmacology*; D000641:Ammonia / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014148:Tranexamic Acid / Q000494:pharmacology*
D000614:Aminocaproates; D003509:Cyclohexanecarboxylic Acids; D000431:Ethanol; D014148:Tranexamic Acid; D000641:Ammonia; D005341:Fibrinolysin