[The pharmacological activities of musk. III. On the mechanisms of its anti-inflammatory activities].
The water soluble fraction (WSF) of musk was shown to decrease the vitamin C content of the adrenal gland in mice and to increase plasma corticosterone levels in rats. The anti-inflammatory effect of WSF was not affected by hypophysectomy in the rat but was completely abolished by adrenalectomy in mice, indicating that the adrenal gland may play an important role in mediating the anti-inflammatory effect of musk. The WSF was capable of inhibiting ADP or collagen-induced platelet aggregation in rats. In the meantime, there was a potentiation of immunohemolysis in mice and an elevation of the plasma level of cAMP in rats. The implications of these changes in the anti-inflammatory effects of musk are discussed.
Zhu
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D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000188:drug therapy; D001205:Ascorbic Acid / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D005229:Fatty Acids, Monounsaturated; C008563:musk; D001205:Ascorbic Acid