[Physalaemin-like N-terminal fragments of mammalian tissues, PHLIP-7 and PHLIP-8 do not modify drinking behavior and sodium appetite in rats].
PHLIP-7 and PHLIP-8, two peptides reproducing at least in part the N-terminal aminoacid sequence of physalaemin, have been identified in mammalian tissues. These peptides produce alterations of fighting behaviour in the mouse, but are devoid of any behavioural activity in the rat. This suggests that PHLIP-7 and PHLIP-8 have no affinity for brain receptors involved in the behavioural effects evoked by tachykinins in the rat, and that the brain of this animal is lacking in receptors for the N-terminal sequence of tachykinins.
Venturi
F
F
Istituto di Farmacologia, Università di Camerino, Italy.
Caraffa
E
E
Cucculelli
M
M
Fede
M
M
Fiorelli
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D010803:Physalaemin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride; D015320:Tachykinins / Q000494:pharmacology
D015320:Tachykinins; D010803:Physalaemin; D012965:Sodium Chloride
I frammenti N-terminali fisalemino-simili di tessuti di mammifero, PHLIP-7 e PHLIP-8, non modificano "drinking behaviour" e appetito per il sodio nel ratto.