Predicting mortality in mixed depression and dementia using EEG sleep variables.
The authors report a study of electroencephalographic (EEG) sleep predictors of two-year mortality in 26 elderly patients with mixed symptoms of depression and cognitive impairment. Patients who had died by two-year follow-up were characterized by significantly longer rapid eye movement (REM) sleep latencies at baseline, less robust REM sleep rebound following all-night sleep deprivation, and baseline apnea-hypopnea indexes greater than 3. Logistic regression analysis using the apnea-hypopnea index value and REM latency correctly predicted 77% of survivors and non-survivors. Survival time following initial measurements was significantly correlated with REM sleep time (r = 0.78, p less than .02) and duration of first REM sleep period (r = 0.75, p less than .02). The authors speculate that changes in these predictor variables may indicate impairment in the cholinergic control of cognitive function, REM sleep, and respiratory function.
Hoch
C C
CC
Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213.
Reynolds
C F
CF
Houck
P R
PR
Hall
F
F
Berman
S R
SR
Buysse
D J
DJ
Dahl
R E
RE
Kupfer
D J
DJ
D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000503:physiopathology; D003704:Dementia / Q000401:mortality* / Q000503:physiopathology / Q000523:psychology; D003866:Depressive Disorder / Q000401:mortality* / Q000503:physiopathology / Q000523:psychology; D004569:Electroencephalography; D005162:Factitious Disorders / Q000401:mortality* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D015996:Survival Rate