Mechanism of psychotropic effect of toluene.
An acute 30 min exposure to toluene vapours (0.32 mmol/l of the air) provoked in the rat brain a decrease of total nonesterified fatty acids (arachidonic acid -21.7%, oleic acid -18.3%, stearic acid -7.9% in the brain cortex and arachidonic acid -6.8% in the hypothalamus). The results are in harmony with the hypothesis of the NEFA decreasing effect of the inhibitory substances in the brain.
Sklenovský
A
A
Navrátil
J
J
Chmela
Z
Z
Rypka
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014050:Toluene / Q000494:pharmacology*
D005227:Fatty Acids; D011619:Psychotropic Drugs; D014050:Toluene