title: [Effect of cicletanine on prostacyclin generation in vivo].
abstract: The administration of arachidonic acid to live rabbits if followed by the generation of prostacyclin and/or thromboxane. Cicletanine increased the production of prostacyclin in a first group of rabbits and amplified the prostacyclin/thromboxane ratio in a second group of the thromboxane type. The most probable mechanism for this action is activation of prostacyclin synthase by cicletanine. This was confirmed in the in vivo model by a study of the platelet-vascular wall interaction: tranylcyprominE, a prostacyclin synthase inhibitor, increased the interaction. Under these experimental conditions, cicletanine inhibited the effect of tranylcypromine and completely restored the enzymatic activity of prostacyclin synthase.
authors.affiliation: Laboratoire de physiologie et de physiopathologie, VUB, Bruxelles, Belgique.
authors.forename: R H
authors.initials: RH
authors.lastname: Bourgain
authors.forename: C
authors.initials: C
authors.lastname: Deby
authors.forename: R
authors.initials: R
authors.lastname: Andries
mesh_terms: D000818:Animals; D004232:Diuretics / Q000378:metabolism* / Q000494:pharmacology; D011464:Epoprostenol / Q000096:biosynthesis*; D005665:Furosemide / Q000378:metabolism; D011725:Pyridines; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013928:Thromboxane A2 / Q000096:biosynthesis; D014191:Tranylcypromine / Q000378:metabolism
chemical_list: D004232:Diuretics; D011725:Pyridines; D014191:Tranylcypromine; D013928:Thromboxane A2; D005665:Furosemide; C038068:cicletanine; D011464:Epoprostenol
vernacular_title: Effet du ciclétanine sur la génération de prostacycline in vivo.