[Transmembrane passage of trinitrine and isosorbide dinitrate. Study of natural membranes].
Nitroglycerin pharmacodynamic efficiency is 3 to 4 times higher than isosorbide dinitrate efficiency. Authors put forward that this difference is at least partially pertained to the transmembrane diffusion potential of the molecules. Data of this first study on red cell membranes are in accordance with this hypothesis.
Guyot-Hermann
A M
AM
Ringard
J
J
Parier
J L
JL
Lefebvre
C
C
Barthelemy
C
C
D002463:Cell Membrane Permeability; D004058:Diffusion; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000378:metabolism*; D005996:Nitroglycerin / Q000378:metabolism*; D013997:Time Factors
D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
Etude du passage transmembranaire de la trinitrine et du dinitrate d'isosorbide. Etude sur membrane naturelle.