Inhibition of cyclic AMP efflux by insect pheromones and fatty acids.
Avian erythrocytes export cyclic AMP by a means that prostaglandins A1 and A2, but not other eicosanoids, inhibit (EC50 approximately 45 nM). Several insect pheromones and the fatty acyl components of common membrane phospholipids also inhibit cyclic AMP efflux (EC50 approximately 30 microM). The presence of at least one double bond in the acyl chain enhances the effect. Unlike PGA, fatty acids probably do not act via formation of a glutathione adduct but very likely by altering membrane fluidity. Inhibition of cyclic AMP export provides a mechanism by which products of phospholipid metabolism can influence the cyclic AMP signaling pathway.
Kanter
J R
JR
Department of Pharmacology, University of California, San Diego, La Jolla 92093.
Hagey
L R
LR
Brunton
L L
LL
D000818:Animals; D010856:Columbidae / Q000097:blood*; D000242:Cyclic AMP / Q000097:blood*; D007851:Dodecanol / Q000031:analogs & derivatives / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D007915:Lepidoptera; D008560:Membrane Fluidity / Q000187:drug effects; D009036:Moths; D010675:Pheromones / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology
D005227:Fatty Acids; D010675:Pheromones; D011454:Prostaglandins A; D007851:Dodecanol; C001977:8,10-dodecadien-1-ol; D000242:Cyclic AMP; D005978:Glutathione; C100573:prostaglandin A1