title: Comparative in vitro activity of norfloxacin against resistant Neisseria gonorrhoeae.
abstract: The in vitro activity of seven antibiotics against 52 isolates of Neisseria gonorrhoeae was determined. Against penicillinase-producing Neisseria gonorrhoeae, ceftriaxone was the most active agent (MIC90 0.015 micrograms/ml), followed by ceftizoxime and norfloxacin (MIC90 0.03-0.125 micrograms/ml). Against spectinomycin-resistant Neisseria gonorrhoeae, the most active agents were ceftizoxime, ceftriaxone and norfloxacin (MIC90 0.015-0.125 micrograms/ml). Ceftizoxime, ceftriaxone and norfloxacin were also the most active agents against tetracycline-resistant Neisseria gonorrhoeae (MIC90 0.06-0.125 micrograms/ml). Overall, the rank order of activity from the most to the least active agent was as follows: ceftizoxime (MIC90 0.015 micrograms/ml); ceftriaxone (MIC90 0.06 micrograms/ml); norfloxacin (MIC90 0.125 micrograms/ml); cefoxitin (MIC90 2 micrograms/ml); tetracycline (MIC90 8 micrograms/ml); penicillin (MIC90 greater than 8 micrograms/ml); and spectinomycin (MIC90 greater than 128 micrograms/ml).
authors.affiliation: Clinical Microbiology Service, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065.
authors.forename: S
authors.initials: S
authors.lastname: Ponticas
authors.forename: D L
authors.initials: DL
authors.lastname: Shungu
authors.forename: C J
authors.initials: CJ
authors.lastname: Gill
mesh_terms: D015296:Ceftizoxime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D009643:Norfloxacin / Q000494:pharmacology*; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis; D010406:Penicillins / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013753:Tetracycline Resistance
chemical_list: D010406:Penicillins; D002443:Ceftriaxone; D000198:Spectinomycin; D015296:Ceftizoxime; D010405:Penicillinase; D013752:Tetracycline; D009643:Norfloxacin