DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control.
The rate of DNA synthesis in mouse brown adipose tissue was followed with injections of [3H]thymidine. Cold exposure led to a large increase in the rate of [3H]thymidine incorporation, reaching a maximum after 8 days, whereafter the activity abruptly ceased. A series of norepinephrine injections was in itself able to increase [3H]thymidine incorporation. When norepinephrine was injected in combination with the alpha-adrenergic antagonist phentolamine or with the beta-adrenergic antagonist propranolol, the stimulation was fully blocked by propranolol. It is suggested that stimulation of DNA synthesis in brown adipose tissue is a beta-adrenergically mediated process and that the tissue is an interesting model for studies of physiological control of DNA synthesis.
Rehnmark
S
S
Wenner-Gren Institute, University of Stockholm, Sweden.
Nedergaard
J
J
D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D005260:Female; D051379:Mice; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D010646:Phentolamine / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013936:Thymidine / Q000008:administration & dosage / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D013936:Thymidine; D009638:Norepinephrine; D010646:Phentolamine