title: Activation of ACTH release is mediated by the same molecule as the final mediator, PGE2, of febrile response in rats.
abstract: Increase in the blood level of adrenocorticotropic hormone (ACTH) and fever are induced by i.v. administration of interleukin-1 alpha (IL-1 alpha) in rats. With preinjection of indomethacin, the ACTH and fever responses to i.v. IL-1 alpha were both either greatly reduced or abolished. Intrapreoptic microinjection of prostaglandin E2 (PGE2) caused ACTH and fever responses similar to those seen after i.v. IL-1 alpha. These data suggest that PGE2, a final mediator of fever, may be released by i.v. IL-1 alpha and also act centrally to enhance the release of corticotropic-releasing factor in the brain.
authors.affiliation: Department of Physiology, Yamaguchi University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D015232:Dinoprostone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007375:Interleukin-1; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D015232:Dinoprostone; D007213:Indomethacin