[The study of aflatoxin B1-induced hepatocarcinogenesis of rats and mechanism of selenium's inhibitory effect on carcinogenesis].
Liver cancers of rats were induced by aflatoxin B1. Two other groups were given 3 ppm and 6 ppm selenium in water. It was found that Selenium had distinct inhibitory effect on carcinogenesis. 61% of rats not given selenium came down with liver carcinoma, whereas those given selenium no carcinogenetic changes were found. In the early stage selenium inhibited the formation of liver hyperplastic foci, in the late stage its effect was on the carcinogenetic change of the hyperplastic foci.
Wang
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D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002273:Carcinogens; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D011230:Precancerous Conditions / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000494:pharmacology / Q000627:therapeutic use*
D000348:Aflatoxins; D000970:Antineoplastic Agents; D002273:Carcinogens; D016604:Aflatoxin B1; D012643:Selenium