title: Does HIV cause salivary gland disease?
abstract: HIV-associated salivary gland disease (HIV-SGD) is characterized by enlargement of the major salivary glands and/or xerostomia. HIV does not appear to play a direct role in this disease since it was detected by immunohistochemistry in only occasional lymphocytes in labial salivary glands in two out of six patients; it was not found in the salivary gland epithelial cells. Moreover, HIV was not found in any of 21 saliva samples from seven patients. We conclude that HIV-SGD is not caused by direct infection of the salivary glands with HIV.
authors.affiliation: Oral AIDS Center, University of California, San Francisco.
authors.forename: M
authors.initials: M
authors.lastname: Schiødt
authors.forename: D
authors.initials: D
authors.lastname: Greenspan
authors.forename: J A
authors.initials: JA
authors.lastname: Levy
authors.forename: J A
authors.initials: JA
authors.lastname: Nelson
authors.forename: D
authors.initials: D
authors.lastname: Chernoff
authors.forename: H
authors.initials: H
authors.lastname: Hollander
authors.forename: J S
authors.initials: JS
authors.lastname: Greenspan
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000382:microbiology*; D012466:Salivary Gland Diseases / Q000150:complications*; D012469:Salivary Glands / Q000382:microbiology*
chemical_list: D015483:HIV Antibodies; D015488:HIV Antigens