[Direct screening of antibiotics-siderophores of bacterial origin].
Antifungal activity of 275 strains belonging to 15 species of Pseudomonas was studied with using media containing no iron or supplemented with 100 micrograms/ml of FeCl3. 33 per cent of the cultures showed lower activity against phytopathogenic fungi in the presence of iron. Addition of this element did not influence the antifungal activity of phenazin and floroglucin derivatives isolated from Pseudomonas cultures. However, its addition markedly lowered the antifungal effect of some crude antibiotics and fluorescent pigments. A scheme for screening siderophore antibiotics with using Pseudomonas cultures is described.
Smirnov
V V
VV
Kiprianova
E A
EA
Boĭko
O I
OI
Kolesova
E A
EA
D000935:Antifungal Agents / Q000096:biosynthesis*; D003470:Culture Media; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000096:biosynthesis*; D011549:Pseudomonas / Q000378:metabolism*; D017262:Siderophores
D000935:Antifungal Agents; D003470:Culture Media; D007502:Iron Chelating Agents; D017262:Siderophores; D007501:Iron
Napravlennyi skrining antibiotikov-sideroforov bakterial'nogo proiskhozhdeniia.