title: Long-term effects of lithium on the kidney: functional-morphological correlations.
abstract: Correlations between quantitative kidney biopsy findings and clinical renal function in 46 unselected patients treated with lithium for an average of eight years were studied. A significant relationship between maximum renal concentrating capacity and degree of tubular atrophy was found. GFR correlated significantly with sclerotic glomeruli as well as atrophic tubules in patients on a multiple dosage schedule, whereas no relationship was seen in patients receiving lithium in a single daily dose. Thus, renal dysfunction may have a structural basis in a subgroup of lithium-treated patients on a multiple dosage schedule.
authors.affiliation: Department of Psychiatry, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Hetmar
authors.forename: C
authors.initials: C
authors.lastname: Brun
authors.forename: J
authors.initials: J
authors.lastname: Ladefoged
authors.forename: S
authors.initials: S
authors.lastname: Larsen
authors.forename: T G
authors.initials: TG
authors.lastname: Bolwig
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001714:Bipolar Disorder / Q000188:drug therapy*; D002951:Citrates; D003692:Delayed-Action Preparations; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000473:pathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000473:pathology; D007677:Kidney Function Tests; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D016651:Lithium Carbonate; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
chemical_list: D002951:Citrates; D003692:Delayed-Action Preparations; D016651:Lithium Carbonate; C070669:lithium citrate; D008094:Lithium