The suppressor factor NBxFO is not species-specific.
The NBxFO factor was obtained from the supernatant liquids of neonatal spleen: myeloma fusions. Previously it had been shown that this factor could inhibit the proliferative response of alloreactive T cell lines. In this study the factor was found to inhibit the MLR of the parent species (mouse) as well as the MLRs of humans and rats. Thus, the NBxFO factor has activity that is not species-specific. Furthermore, the factor was found to inhibit the lectin-induced mitogenesis of these 3 species. Gel chromatography revealed that the moleclar weight of the molecule responsible for suppressing human lymphocyte mitogenesis is the same as previously determined for suppression of mouse proliferative responses.
Barton
B E
BE
Department of Medicine, Stanford University Medical Center, CA 94305.
D000818:Animals; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D006825:Hybridomas; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D051381:Rats; D011912:Rats, Inbred ACI; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013491:Suppressor Factors, Immunologic / Q000276:immunology*
D013491:Suppressor Factors, Immunologic