title: [The intraocular pressure lowering effect of human atrial peptide].
abstract: The human atrial natriuretic factor (hANF) is a cardiovascular hormone, which promotes renal sodium secretion in response to increases in extracellular fluid volume and atrial pressure. It regulates sodium and volume homeostasis. Specific receptors for hANF have been identified in the ciliary processes of rats and rabbits, which mediated a long-lasting reduction in intraocular pressure (IOP) after intra-atrial injection. In a series of 10 glaucoma patients with bilateral IOP elevations above 33 mmHg an i.v. bolus injection of hANF was administered and IOP was recorded before and over an 8-h period after injection. The human atrial natriuretic factor lowered IOP significantly. The potential of hANF as an antiglaucoma agent is discussed.
authors.forename: M
authors.initials: M
authors.lastname: Diestelhorst
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D005901:Glaucoma / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*
chemical_list: D009320:Atrial Natriuretic Factor
vernacular_title: Zur augendrucksenkenden Wirkung von humanem atrialen Peptid (HAP).