title: Osmotic fragility of sheep erythrocytes and alterations in their membrane constituents in Dictyocaulus filaria infection.
abstract: Alterations in the sheep erythrocyte membrane constituents during the course of Dictyocaulus filaria infection were studied in 4-6 month old Nali lambs. During the acute course of infection, plasma cholesterol, membrane cholesterol, cholesterol: phospholipid ratio and acetylcholinesterase activity fell significantly when compared with uninfected controls. The onset of the fall in the values of these parameters was observed 1-2 weeks prior to an increase in the osmotic fragility of erythrocytes. The altered values persistently remained at sub-normal levels during the chronic stage of the infection. However, the membrane proteins and phospholipids of sheep erythrocytes remained unaffected during the entire period of study. The clinico-parasitological picture of the disease, as judged by the clinical course of disease, faecal larval output and necropsy worm recovery, was typical of ovine dictyocauliosis.
authors.forename: T K
authors.initials: TK
authors.lastname: Bhat
authors.forename: R L
authors.initials: RL
authors.lastname: Sharma
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D002784:Cholesterol / Q000032:analysis; D004022:Dictyocaulus Infections / Q000097:blood*; D004910:Erythrocyte Membrane / Q000032:analysis*; D008297:Male; D009996:Osmotic Fragility; D010743:Phospholipids / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*
chemical_list: D010743:Phospholipids; D002784:Cholesterol; D000110:Acetylcholinesterase