title: Long-term treatment of acne with 20% azelaic acid cream.
abstract: Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris. During the period of 1982-86 we carried out two studies with 20% AZA cream in patients with acne to determine its clinical indications and therapeutic schedules. The first, open study was of 100 unselected patients of either sex, while a second group of 30 patients formed a part of a larger (309 patients) multicentre single-blind comparison of topical AZA vs. 5% benzoylperoxide (BPO) gel for the treatment of papulopustular acne. The rates of improvement obtained indicate that topical AZA can be considered an effective therapy chiefly for papulo-pustular acne, with a very good local tolerance.
authors.affiliation: First Clinic of Dermatology, University of Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cavicchini
authors.forename: R
authors.initials: R
authors.lastname: Caputo
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000627:therapeutic use; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D013997:Time Factors
chemical_list: D003998:Dicarboxylic Acids; C010038:azelaic acid; D001585:Benzoyl Peroxide