title: A comparison of the category fluency deficits associated with Alzheimer's and Huntington's disease.
abstract: The supermarket verbal fluency test of the Dementia Rating Scale (DRS) was administered to 20 patients with mild Alzheimer's disease (Mi-DAT), 20 patients with moderately severe Alzheimer's disease (Mo-DAT), 20 patients with Huntington's disease (HD), and 40 normal control subjects. The findings confirmed previous reports that Mo-DAT patients retrieved fewer words per category of supermarket items sampled and had a greater propensity to generate category labels (superordinates) than did intact controls. Similar disruptions of the structure of semantic knowledge were also noted in the fluency performances of the Mi-DAT and HD patients. The Mi-DAT patients' tendency to generate few exemplars for each category sampled suggested that a significant disruption in the structure of semantic knowledge occurred even in the earliest stages of DAT. When the present fluency findings for the HD patients were considered with previous reports of linguistic changes in this disorder, it appeared that HD patients' deterioration in semantic knowledge involved associative changes rather than the bottom-up breakdown associated with DAT.
authors.affiliation: Department of Psychiatry, University of California, San Diego.
authors.forename: A I
authors.initials: AI
authors.lastname: Tröster
authors.forename: D P
authors.initials: DP
authors.lastname: Salmon
authors.forename: D
authors.initials: D
authors.lastname: McCullough
authors.forename: N
authors.initials: N
authors.lastname: Butters
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D000849:Anomia / Q000523:psychology; D001037:Aphasia / Q000523:psychology*; D001041:Aphasia, Wernicke / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000523:psychology*; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D012660:Semantics; D013068:Speech Production Measurement