Human SSAV-related endogenous retroviral element: LTR-like sequence and chromosomal localization to 18q21.
A new family of human endogenous retroviral sequences was recently discovered by way of its relationship to the simian sarcoma-associated virus (SSAV). One molecular clone, termed S71, contains sequences related to the genes coding for the group-specific antigens (gag) and polymerase (pol) proteins of SSAV. At the 3' end of this human retroviral element we have now found a 535-bp region which shows features characteristics of a retroviral long terminal repeat, including potential signal sequences essential for transcriptional control. By means of Southern blotting and in situ hybridization, the sequence was mapped to chromosome 18 band q21.
Brack-Werner
R
R
Abt. für Molekulare Zellpathologie, Gesellschaft für Strahlen-und Umweltforschung, Neuherberg, Federal Republic of Germany.
Barton
D E
DE
Werner
T
T
Foellmer
B E
BE
Leib-Mösch
C
C
Francke
U
U
Erfle
V
V
Hehlmann
R
R
D000818:Animals; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D003001:Cloning, Molecular; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D015683:Gene Products, gag; D005814:Genes, Viral; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D009857:Oncogenes; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D012191:Retroviridae Proteins / Q000235:genetics; D015301:Retroviruses, Simian / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics*
D015683:Gene Products, gag; D012191:Retroviridae Proteins; D004247:DNA