title: [Anticarcinogenesis activity of natural carotenes].
abstract: Natural carotene sample obtained from palm oil was proved to suppress the promoting stage of two-stage carcinogenesis of mouse skin, and also inhibit the proliferation of human malignant tumor cells, such as neuroblastoma GOTO cells, stomach cancer HGC-27 cells, and pancreatic cancer PANC-I cells. Among the major constituents of palm carotene, alpha-carotene showed stronger anti-proliferative effect than beta-carotene. The present results indicate that further investigation for not only beta-carotene but also other kinds of natural carotenes, such as alpha-carotene, should be carried out.
authors.affiliation: Département de Biochimie, Université Médicale de la Préfecture de Kyoto, Japon.
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: J
authors.initials: J
authors.lastname: Takayasu
authors.forename: A
authors.initials: A
authors.lastname: Iwashima
authors.forename: M
authors.initials: M
authors.lastname: Murakoshi
authors.forename: J
authors.initials: J
authors.lastname: Imanishi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D002338:Carotenoids / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010938:Plant Oils; D002338:Carotenoids
vernacular_title: Activité anticarcinogénétique des carotènes naturels.