AP1, a composite transcription factor implicated in abnormal growth control.
Growth factors activate cascades of intracellular events, some of which result in altered gene expression. A series of recent discoveries have highlighted the role of the transcription factor AP1 as a mediator of the effects of growth factors, as well as those of oncogenes and the tumour promoter TPA. We discuss the molecular composition of AP1, how its activity is thought to be regulated, and the evidence that AP1 activation is involved in transformation.
Imler
J L
JL
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Wasylyk
B
B
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009857:Oncogenes; D016755:Proto-Oncogene Proteins c-jun; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D013755:Tetradecanoylphorbol Acetate