[Lethal and mutagenic effect of incorporated 6-3H-pyrimidines on extracellular phage lambda].
A study was made of lethal and mutagenic effects of 6-3H-thymidine and 6-3H-cytosine, incorporated into DNA, on extracellular phage lambda. The lethal effects of both 6-3H-pyrimidines (the number of lethal hits per 3H decay) do not differ from those of [3H-methyl]thymidine and 5-3H-cytosine. The mutagenic effects (at equal survival rates) are as follows: 6-3H-thymidine approximately 3H2O less than [3H-methyl]thymidine less than 6-3H-cytosine less than 5-3H-cytosine. UV-irradiation of host cells induces a more pronounced W-mutagenesis with 6-3H-cytosine than with 6-3H-thymidine.
Konevega
L V
LV
Kalinin
V L
VL
D010582:Bacteriophage lambda / Q000378:metabolism / Q000528:radiation effects*; D003596:Cytosine / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism / Q000528:radiation effects*; D009154:Mutation; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D004279:DNA, Viral; D014316:Tritium; D003596:Cytosine; D013936:Thymidine
Letal'noe i mutagennoe deĭstvie inkorporirovannykh 6-3H-pirimidinov na vnekletochnyĭ fag lambda.