title: [Role of cyclic AMP in gastric secretion. The secretion and mechanism of action of gastrin].
abstract: The present study involved evaluation of the role played by cyclic AMP on the secretion and mechanism of action of gastrin in man. On the basis of the results obtained, gastrin secretion induced by an excessive rise in gastric pH is accompanied by a simultaneous increase in plasma cyclic AMP concentrations (p less than 0.05) as well as a tissue cyclic AMP in the region of the fundus (p less than 0.001). By contrast, no significant change was seen regarding antropyloric AMP. As a result, it is felt that cyclic AMP does not play a direct role in the secretion of gastrin by G cells but is a mediator of the mechanism of action of gastrin in terms of the secretion of HCl by the parietal cell.
authors.affiliation: Service de Chirurgie Générale, Hôpital Sismanoglion, Athènes, Grèce.
authors.forename: P
authors.initials: P
authors.lastname: Karydakis
authors.forename: G
authors.initials: G
authors.lastname: Papastratis
authors.forename: D
authors.initials: D
authors.lastname: Alexiou
authors.forename: C
authors.initials: C
authors.lastname: Simopoulos
authors.forename: C
authors.initials: C
authors.lastname: Carydakis
authors.forename: C
authors.initials: C
authors.lastname: Miras
authors.forename: G
authors.initials: G
authors.lastname: Skalkeas
mesh_terms: D000242:Cyclic AMP / Q000097:blood / Q000502:physiology*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans
chemical_list: D005755:Gastrins; D000242:Cyclic AMP
vernacular_title: Le rôle de l'AMP cyclique dans la sécrétion gastrique. Sécrétion et mécanisme d'action de la gastrine.