Nongenomic interactions of retinoic acid and thyroid hormone at the plasma membrane.
Both thyroxine (T4) and 3,3'5-L-tri-iodothyronine (T3) can activate the calcium-magnesium-dependent adenosine triphosphatase (ATP-ase) in plasma membranes of enucleate erythrocytes. This activation of Ca2+-ATPase is blocked by retinoic acid and perhaps by competing T4-binding sites on the membranes.
D000252:Calcium-Transporting ATPases / Q000097:blood; D004789:Enzyme Activation; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans; D013963:Thyroid Hormones / Q000502:physiology*; D014212:Tretinoin / Q000494:pharmacology*
D013963:Thyroid Hormones; D014212:Tretinoin; D000252:Calcium-Transporting ATPases