Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.
Human herpesvirus 6 (HHV-6)-related virus was isolated from CD4+ CD8- and CD3+ CD4+ mature T lymphocytes but could not be isolated from CD4- CD8+, CD4- CD8-, and CD3- T cells in the peripheral blood of exanthem subitum patients. HHV-6-related virus predominantly infected CD4+ CD8+, CD4+ CD8-, and CD3+ CD4+ cells with mature phenotypes and rarely infected CD4- CD8+ cells from cord blood mononuclear cells, which suggested predominant CD4 mature T-lymphocyte tropism of HHV-6-related virus.
Takahashi
K
K
Department of Virology, Research Institute for Microbial Diseases, Osaka University, Japan.
Sonoda
S
S
Higashi
K
K
Kondo
T
T
Takahashi
H
H
Takahashi
M
M
Yamanishi
K
K
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D016827:CD8 Antigens; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D018139:Simplexvirus / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens