[Study of the effect of analgeton on the release of beta-endorphin and its effect on chronic hyperalgesia].
The effect of the combined preparation analgeton and its components--analgin (metamizol, noramidopyrindimethansulfonate) and aminton (2-amino-4-methyl-pyridinphosphate) was studied on the release of beta-endorphin and its influence on chronic hyperalgesia. Experiments were carried out in vivo and in vitro on white rats and it was established that analgin, aminton and analgeton stimulated the release of beta-endorphin, affecting various regulatory levels. Analgeton in contrast to analgin showed longer analgetic effect in animals with chronic hyperalgesia (adjuvant arthritis of white rats). Possibilities for pharmacological control of chronic pain by influencing the levels of endogenous opioids are discussed.
Vlaskovska
M
M
Krushkov
I
I
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D002908:Chronic Disease; D004177:Dipyrone / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D006930:Hyperalgesia / Q000378:metabolism*; D006941:Hyperesthesia / Q000378:metabolism*; D008297:Male; D010148:Intractable Pain / Q000188:drug therapy; D010847:Picolines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000378:metabolism*
D004338:Drug Combinations; D010847:Picolines; D000632:Aminopyrine; C015672:2-amino-4-picoline; D001615:beta-Endorphin; D004177:Dipyrone
Prouchvane na efekta na analgeton vŭrkhu osvobozhdavaneto na beta-endorfin i povliiavaneto na khronichna khiperalgeziia.