title: Repair of spinal dural defects with vicryl (polyglactin 910) mesh.
abstract: This study examined and compared the effectiveness of woven vicryl (polyglactin 910) mesh and lyophilized cadaver dura (Lyodura) for the repair of spinal dural defects. A woven vicryl mesh was used to repair spinal dural defects in 16 mongrel dogs. As an internal control, all animals had a separate dural incision that was closed with 9-0 vicryl suture. Animals were killed, and results were evaluated at 4, 8, 12, and 24 weeks. The repair of dural defects was achieved in all animals, and there were no cases of pseudo-meningocele formation, cerebrospinal fluid leakage, or postoperative infection. The vicryl mesh served as a latticework for formation of a neodural membrane. Inflammatory or reactive response to vicryl mesh was minimal, and no adhesion to underlying neural structures was noted. The neodural membrane formed in the animals in which lyophilized dura was employed was usually thicker than those in which vicryl mesh was used and was associated with thick arachnoid-neural adhesions in two of eight animals. We believe vicryl mesh is a suitable dural substitute and offers promise for use in clinical situations.
authors.affiliation: Department of Neurosurgery, University of Cincinnati, Ohio 45267-0515.
authors.forename: J T
authors.initials: JT
authors.lastname: Keller
authors.forename: S M
authors.initials: SM
authors.lastname: Weil
authors.forename: C M
authors.initials: CM
authors.lastname: Ongkiko
authors.forename: J M
authors.initials: JM
authors.lastname: Tew
authors.forename: F H
authors.initials: FH
authors.lastname: Mayfield
authors.forename: S B
authors.initials: SB
authors.lastname: Dunsker
mesh_terms: D000818:Animals; D002102:Cadaver; D004285:Dogs; D004388:Dura Mater / Q000473:pathology / Q000601:surgery*; D005612:Freeze Drying; D009417:Nerve Tissue / Q000637:transplantation; D011098:Polyglactin 910; D019736:Prostheses and Implants; D013118:Spinal Cord Diseases / Q000473:pathology / Q000601:surgery*
chemical_list: D011098:Polyglactin 910