Plasma concentrations of atrial natriuretic peptide in children with persistent hypertension.
Plasma concentrations of human atrial natriuretic peptide (hANP) were determined in children with persistent hypertension and in age-matched normotensive controls. We studied 40 children 6-7 years of age (Group A), and 74 children 13-14 years of age (Group B). There was no significant difference in plasma hANP concentration between hypertensives and normotensives in group A. In group B, the plasma hANP concentration in hypertensives (86.5 +/- 44.9 pg/ml: mean +/- SD) was significantly higher than in normotensives (58.8 +/- 40.4 pg/ml) (p less than 0.01). In group B, 24-hour urinary excretion of sodium and fractional excretion of sodium were not significantly different between hypertensives and normotensives. The plasma hANP correlated significantly with the fractional excretion of sodium (p less than 0.05) and the 24-hour urinary excretion of sodium (p less than 0.01) in normotensives. No such correlation was evident in the case of the hypertensives. The pathogenesis of increased plasma hANP concentration in older children with persistent hypertension remains to be investigated. In regard to the effects of hANP on renal function, hANP may contribute to the regulation of sodium handling in normotensive adolescents, whereas other regulatory mechanisms need to be considered in the case of hypertensives.
Ito
Y
Y
Kinoshita
S
S
Kato
H
H
Marumo
F
F
Ando
K
K
D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001835:Body Weight; D002648:Child; D003404:Creatinine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007564:Japan; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood / Q000652:urine
D009320:Atrial Natriuretic Factor; D012964:Sodium; D003404:Creatinine; D011188:Potassium