title: [Antitubercular agents. 45. Antimycobacterial thiohydrazide].
abstract: The present paper investigates the activity of thiohydrazides containing a structural fragment of oxalic acid against Mycobacterium tuberculosis and Mycobacterium kansasii. The drugs included heterocyclic compounds as well. All compounds under study show medium activity. The minimal inhibition concentrations against Mycobacterium kansasii are approximately 3 times higher than against Mycobacterium tuberculosis. The most effective aromatic compounds have the RM values (silica gel impregnated with silicon oil-water) in the interval of 2.2-2.6.
authors.affiliation: Lehrstuhl für anorganische und organische Chemie, Pharmazeutische Fakultät der Karls-Universität, Hradec Králové, DDR.
authors.forename: K
authors.initials: K
authors.lastname: Waisser
authors.forename: Z
authors.initials: Z
authors.lastname: Odlerová
authors.forename: N
authors.initials: N
authors.lastname: Houngbedji
authors.forename: W
authors.initials: W
authors.lastname: Thiel
authors.forename: R
authors.initials: R
authors.lastname: Mayer
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D006834:Hydrazines / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D010070:Oxalates / Q000494:pharmacology*; D019815:Oxalic Acid; D012044:Regression Analysis
chemical_list: D000995:Antitubercular Agents; D006834:Hydrazines; D010070:Oxalates; D019815:Oxalic Acid
vernacular_title: Antituberkulotika. 45. Mitteilung: Antimykobakterielle Thiohydrazide.