[Salsolinol, an endogenous molecule. Possible implications in alcoholism, Parkinson's disease and pain].
Salsolinol can be formed either by condensation of dopamine with acetaldehyde, or by condensation of dopamine with pyruvic acid followed by decarboxylation. Salsolinol has a complex pharmacologic profile. Its opium-like activity may be related to alcohol dependency and to the effectiveness of naloxone during acute alcohol intoxication. Because they had noticed that alcoholism and Parkinson's disease rarely coexist, the authors undertook a study to confirm this fact and attempt to explain it by implicating salsolinol. Urinary excretion of salsolinol was found to increase following ingestion of alcohol, as well as in Parkinson patients under L-dopa treatment. The authors also found that urinary salsolinol was very low in untreated patients with Parkinson's disease. Salsolinol was detected in a number of foods and beverages. Separate assays of enantiomeres showed that the S enantiomere predominates in some foods whereas the R enantiomere is more abundant in humans. Lastly, the antinociceptive effects of salsolinol and its enantiomeres were studied in mice and antidepressant effects were evidenced using predictive tests.
Vernay
D
D
Service de Neurologie, Hôpital Nord, Clermont-Ferrand.
Eschalier
A
A
Durif
F
F
Aumaitre
O
O
Rigal
B
B
Ben Sadoun
A
A
Fialip
J
J
Marty
H
H
Philip
E
E
Bougerolle
A M
AM
D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000378:metabolism*; D000700:Analgesics; D000928:Antidepressive Agents / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*
D000700:Analgesics; D000928:Antidepressive Agents; D007546:Isoquinolines; D004295:Dihydroxyphenylalanine; C036617:salsolinol
Le salsolinol, molécule endogène. Possibles implications dans l'alcoolisme, la maladie de Parkinson et la douleur.