Calomys callidus as a potential Junin virus reservoir.
The present study investigated whether C. callidus, a species belonging to the Calomys genus, is capable of developing experimentally a persistent Junin virus (JV) infection. Newborn and adult cricetids were inoculated with the attenuated XJ-Clone 3 strain of JV by intracerebral or mucosal route. The present results indicate that the species is susceptible to JV infection, capable of shedding virus chronically through saliva and developing a persistent infection as shown by the detection of virus in brain tissue at 60 days post infection. These findings, and the fact that this cricetid shares its distribution areas with Calomys musculinus and Akodon azarae, support C. callidus as a potential JV reservoir.
Videla
C
C
Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Kajon
A
A
Carballal
G
G
Weissenbacher
M
M
D000818:Animals; D001116:Arenaviridae / Q000472:pathogenicity*; D006477:Arenaviruses, New World / Q000302:isolation & purification / Q000472:pathogenicity*; D003411:Arvicolinae / Q000382:microbiology*; D004197:Disease Reservoirs; D005260:Female; D005455:Fluorescent Antibody Technique; D006478:Hemorrhagic Fever, American / Q000635:transmission*; D007928:Lethal Dose 50; D051379:Mice; D012376:Rodent Diseases / Q000453:epidemiology / Q000382:microbiology*; D012463:Saliva / Q000382:microbiology; D012699:Serology