title: Sex difference of the metabolic disposition of clioquinol in rats.
abstract: The order of plasma levels of clioquinol and its conjugates in male rats after intraduodenal administration of 32.7 mumol/kg dose of clioquinol was clioquinol sulfate (C-Sul) greater than glucuronide (C-Glu) much greater than clioquinol, whereas that in female rats was C-Glu greater than C-Sul much greater than clioquinol. Total (urine + bile) recovery was almost the same among male and female rats. The percentage of excretion amounts of C-Sul (urine + bile) to the total excretion amounts for 24 h in male rats after intravenous administration of clioquinol was about twice that in female rats, while the percentage of excretion amounts of C-Glu to the total excretion amounts in male rats was smaller than that in female rats. In intravenous administration of 16.4 mumol/kg dose of C-Glu, C-Sul and clioquinol other than C-Glu were found in bile and urine of male and female rats. The percentage of excretion amounts of C-Sul and C-Glu (urine + bile) to the total excretion amounts was similar among male and female rats, respectively. In intravenous administration of 16.4 mumol/kg dose of C-Sul, C-Glu and clioquinol other than C-Sul were found in bile and urine of male and female rats, and the percentage of excretion amounts of C-Sul (urine + bile) to the total excretion amounts in male rats was 1.3 fold that in female rats.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hospital Pharmacy, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohshima
authors.forename: H
authors.initials: H
authors.lastname: Kotaki
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: F
authors.initials: F
authors.lastname: Nakagawa
authors.forename: Z
authors.initials: Z
authors.lastname: Tamura
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D007464:Clioquinol / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D005260:Female; D006912:Hydroxyquinolines / Q000378:metabolism*; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics
chemical_list: D006912:Hydroxyquinolines; C062045:clioquinol glucuronide; D007464:Clioquinol