title: The effects of ipratropium bromide and fenoterol nebulizer solutions in children with asthma.
abstract: The effects of nebulized solutions of ipratropium bromide and fenoterol combined were compared with the response to either preparation alone in single dose and longer-term administration in children who had asthma. The combination produced a slightly greater response than either alone, especially in peak expiratory flow. Over a 1-month period, there were no significant differences in symptom scores or lung function parameters between the combination of ipratropium bromide and fenoterol and fenoterol alone in a group of children who had asthma. It is possible that the addition of ipratropium bromide to a sympathomimetic drug may be useful in a subgroup of asthmatics, particularly if there is a considerable large airway contribution to bronchial narrowing.
authors.affiliation: Professional Department of Thoracic Medicine, Royal Children's Hospital, Melbourne, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Freeman
authors.forename: L I
authors.initials: LI
authors.lastname: Landau
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001286:Atropine Derivatives / Q000008:administration & dosage*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage*; D008176:Lung Volume Measurements; D008297:Male; D009330:Nebulizers and Vaporizers; D011897:Random Allocation; D013997:Time Factors
chemical_list: D001286:Atropine Derivatives; D005280:Fenoterol; D009241:Ipratropium