title: Blood lactate as a prognosticator of survival following hemorrhage in conscious swine.
abstract: Arterial blood lactate concentration at the end of fixed volume hemorrhage was evaluated as a predictor of survival in unmedicated chronically instrumented immature swine. Compared to basal values, 8.4 +/- 4.5 mg/dl (means +/- SD, n = 52), hemorrhaged animals (n = 71) with a lactate of 43.9 +/- 37.1 mg/dl lived while animals (n = 65) with a lactate of 106.5 +/- 40.4 mg/dl died. Lactate concentration at the end of hemorrhage successfully predicted survival (81.0%). Prospective evaluation, using a blood lactate concentration of 125 mg/dl (n = 27), showed a predictive success of 81.0%. Arterial plasma lactate concentration at the end of hemorrhage thus may be used to predict survival in the conscious swine.
authors.affiliation: Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
authors.forename: C E
authors.initials: CE
authors.lastname: Wade
authors.forename: D S
authors.initials: DS
authors.lastname: Trail
authors.forename: V L
authors.initials: VL
authors.lastname: Gildengorin
authors.forename: J P
authors.initials: JP
authors.lastname: Hannon
mesh_terms: D000818:Animals; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D007773:Lactates / Q000097:blood*; D008297:Male; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000097:blood* / Q000401:mortality
chemical_list: D007773:Lactates