title: Percutaneous transluminal renal angioplasty in management of atherosclerotic renovascular hypertension: results in 100 patients.
abstract: The long-term effect of percutaneous transluminal renal angioplasty (PTRA) on blood pressure and renal function was assessed in 100 consecutive patients with atherosclerotic renovascular hypertension. Technical success rates (complete plus partial) of a first PTRA averaged 76.2%, 74.1%, and 67.7% for the unilateral (n = 42), bilateral (n = 27), and solitary (n = 31) groups, respectively. Of the technical successes, 59% (43/73) experienced sustained blood pressure benefit (mostly amelioration) during a mean follow-up period of 29 months. Rates of blood pressure benefit were similar in the three groups. Ostial lesions comprised the majority of blood pressure benefit failures. Repeat angioplasty in 14 patients resulted in a 71% technical success rate and a 50% blood pressure benefit rate during a mean follow-up period of 22 months. Long-term stability of mean serum creatinine level was observed after technically successful angioplasty in all three groups. Acute renal insufficiency, which was reversible in all but one patient, complicated 26% of the procedures. Mechanical complications occurred in 14% (20/145) of the arteries acted on; surgical intervention was required in five patients. The mortality rate was 2%. These results suggest that angioplasty is effective in both the long-term management of renovascular hypertension and the preservation of renal function in a large fraction of patients with atherosclerotic renovascular hypertension.
authors.affiliation: Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: V J
authors.initials: VJ
authors.lastname: Canzanello
authors.forename: V G
authors.initials: VG
authors.lastname: Millan
authors.forename: J E
authors.initials: JE
authors.lastname: Spiegel
authors.forename: P S
authors.initials: PS
authors.lastname: Ponce
authors.forename: R I
authors.initials: RI
authors.lastname: Kopelman
authors.forename: N E
authors.initials: NE
authors.lastname: Madias
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000800:Angioplasty, Balloon / Q000009:adverse effects; D001161:Arteriosclerosis / Q000150:complications*; D001794:Blood Pressure; D006801:Humans; D006978:Hypertension, Renovascular / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000503:physiopathology