title: Phosphate binding efficiency of a polyuronic acid in normal subjects.
abstract: We evaluated the phosphate-binding efficiency of Sorbiphos, a non-toxic aluminium-free natural polymer, in five volunteers aged 28-34 years with normal renal function. After an overnight fast, a placebo, 2 g of Sorbiphos or a therapeutic dose of Alu-Cap (950 mg) were given, 30 min before a dietary load of phosphorus. Serum and urinary phosphate were measured on hourly samples. A similar increment in serum and urine phosphate was noted after the ingestion of placebo or Sorbiphos, but both serum and urine phosphate increased less after Alu-Cap. Since the recommended dose of Sorbiphos is half that of Alu-Cap, we conclude that Sorbiphos has little phosphate-binding efficiency in normal subjects given moderate phosphate loads.
authors.affiliation: Department of Human Metabolism, University of Sheffield Medical School, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Hamdy
authors.forename: E V
authors.initials: EV
authors.lastname: McCloskey
authors.forename: V A
authors.initials: VA
authors.lastname: Naylor
authors.forename: C B
authors.initials: CB
authors.lastname: Brown
authors.forename: J A
authors.initials: JA
authors.lastname: Kanis
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011108:Polymers / Q000494:pharmacology*; D012016:Reference Values; D014574:Uronic Acids / Q000494:pharmacology*
chemical_list: D010710:Phosphates; D011108:Polymers; C063220:Sorbiphos; D014574:Uronic Acids; D000536:Aluminum Hydroxide