title: Bone disorder in cardiomyopathic hamsters.
abstract: Bones of cardiomyopathic hamsters (UM-X7.1 Syrian hamsters), at 5, 10 and 20 weeks of age, were compared chemically and histomorphologically with those of normal Syrian hamsters. Femurs of UM-X7.1 hamsters were significantly shorter than those of normal hamsters, and the mean dry weight, mean volume, mean ash weight per unit bone volume and mean ash as a percentage of dry weight of femurs were all significantly less in UM-X7.1 hamsters. The bone disorder preceded the myocardial calcium precipitation and myocardial hypertrophy in the cardiomyopathic hamsters. In addition, the percentage of cortical area measured on the cross-section of tibia and the appositional rate of bone minerals, determined by a tetracycline labelling technique, were also lower in the UM-X7.1 hamsters. These findings suggest that the bone disorder was associated with decreased bone formation in the UM-X7.1 Syrian hamsters.
authors.affiliation: Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Togari
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tarumoto
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D006332:Cardiomegaly; D009202:Cardiomyopathies / Q000378:metabolism / Q000473:pathology*; D006224:Cricetinae; D005260:Female; D005269:Femur / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*; D008647:Mesocricetus; D009206:Myocardium / Q000032:analysis / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002118:Calcium