Inhibition of glycosylation processing alters the growth parameters of cells transformed by the oncogene of simian sarcoma virus.
Normal rat kidney (NRK) cells transformed by the v-sis oncogene of simian sarcoma virus (SSV) were treated with the glucosidase I inhibitor castanospermine. The inhibitor did not change cell morphology, but specific growth parameters such as serum- and anchorage-independence were lost.
Hadwiger-Fangmeier
A
A
Institut für Medizinische Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
Niemann
H
H
Tamura
T
T
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D005814:Genes, Viral / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors; D006031:Glycosylation; D007212:Indolizines; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009857:Oncogenes / Q000187:drug effects; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D051381:Rats; D015301:Retroviruses, Simian / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000187:drug effects / Q000235:genetics*; D000520:alpha-Glucosidases; D054836:Indolizidines
D000470:Alkaloids; D065089:Glycoside Hydrolase Inhibitors; D007212:Indolizines; D000520:alpha-Glucosidases; C042059:glucosidase I; C037806:castanospermine; D054836:Indolizidines