7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.
Djuric
S W
SW
Gastrointestinal Diseases Research, G.D. Searle and Co., Skokie, Illinois 60077.
Collins
P W
PW
Jones
P H
PH
Shone
R L
RL
Tsai
B S
BS
Fretland
D J
DJ
Butchko
G M
GM
Villani-Price
D
D
Keith
R H
RH
Zemaitis
J M
JM
D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003092:Colitis / Q000188:drug therapy; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000201:enzymology; D006168:Guinea Pigs; D006801:Humans; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D009195:Peroxidase / Q000378:metabolism; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000502:physiology; D018102:Receptors, Leukotriene B4
D001578:Benzopyrans; D011971:Receptors, Immunologic; D018102:Receptors, Leukotriene B4; C059950:SC 41930; D007975:Leukotriene B4; D009195:Peroxidase