title: Multiphenotypic lymphoma with rearrangements of the T cell receptor beta chain and gamma chain genes.
abstract: A case of chemotherapy-resistant non-Hodgkin's lymphoma simultaneously expressing T cell (CD7)-, B cell (CD19)- and myeloid (CD13, CD33)-associated surface antigens is presented. Cytochemical analysis revealed that the lymphoma cells were positive for terminal deoxynucleotidyl transferase, but negative for myeloperoxidase and esterase. Rearrangements of both the T cell receptor beta chain and gamma chain genes were observed, but the immunoglobulin genes showed a germ line configuration. The rearrangement was not detected within the breakpoint cluster region on chromosome 22. These findings are considered to represent aberrant expressions of the B cell- and myeloid-associated antigens in early-stage T cell lineage lymphoma cells.
authors.affiliation: First Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yasukawa
authors.forename: N
authors.initials: N
authors.lastname: Kanemitsu
authors.forename: A
authors.initials: A
authors.lastname: Inatsuki
authors.forename: H
authors.initials: H
authors.lastname: Mise
authors.forename: K
authors.initials: K
authors.lastname: Iwamasa
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000201:enzymology; D002892:Chromosomes, Human, Pair 22; D015342:DNA Probes; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D005838:Genotype; D006651:Histocytochemistry; D006801:Humans; D016256:Lewis X Antigen / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D008297:Male; D010641:Phenotype
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015342:DNA Probes; D016256:Lewis X Antigen