In vivo assessment of 111In-labeled hematoporphyrin derivative in breast tumor-bearing animals.
The biological behavior of 111In-labeled HPD has been investigated in tumor-bearing animals. Mice mammary adenocarcinomas and 7,12-dimethylbenz(a)anthracine induced breast tumors in Sprague-Dawley female rats were clearly visualized by 111In-HPD nuclear scintigraphy. Optimal scans were obtained after a 48 h delay. In normal and tumor-bearing animals, the highest uptake of 111In-HPD 72 h post-injection was found in the liver, the spleen and the kidneys. Depending on the size and the extent of necrosis, the uptake of 111In-HPD by malignant breast tumors varied from 2.5% injected dose (ID) (range 0.14-5.3% ID) in mice to 1% (range 0.22-8.1% ID) in rats. Benign breast tumor uptake of 111In-HPD was less than 1% ID. No significant amount of the radiopharmaceutical was found in pulmonary abscesses and abdominal cysts (less than 0.1% ID). Scintigrams of these infectious or inflammatory lesions were normal. Malignant tumor to blood, heart and lung ratios averaged 50:1, 10:1 and 3:1 respectively. Tumor to brain ratio ranged from 72 to 444:1.
Wong
D W
DW
Department of Radiology, King/Drew Medical Center, U.C.L.A. 90059.
Mandal
A
A
Brown
J
J
Reese
I C
IC
Siegler
R
R
Hyman
S
S
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D000818:Animals; D005260:Female; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000493:pharmacokinetics*; D007205:Indium Radioisotopes; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D006415:Hematoporphyrins; D007205:Indium Radioisotopes; D015127:9,10-Dimethyl-1,2-benzanthracene; D017324:Hematoporphyrin Derivative