Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine.
The bisbenzylisoquinoline alkaloid, tetrandrine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.
Seow
W K
WK
Immunobiology Laboratory Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Ferrante
A
A
Li
S Y
SY
Thong
Y H
YH
D000470:Alkaloids / Q000494:pharmacology*; D044182:Benzylisoquinolines; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003594:Cytoplasmic Granules / Q000187:drug effects; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D009113:Muramidase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D000470:Alkaloids; D044182:Benzylisoquinolines; D007375:Interleukin-1; D013481:Superoxides; C009438:tetrandrine; D009113:Muramidase; D005966:Glucuronidase