[Studies of the effect of a protein-free diet and branched-chain amino acids (preparation Aminosteril-Hepa) on selected biochemical indicators in chronic experimental hepatic encephalopathy].
The latest observations suggest that a decreased level of serum branched-chain amino acids plays a role in the pathogenesis of liver encephalopathy. In this study we analysed the behaviour of the serum concentrations of: ammonia, phenols, alpha-amino nitrogen, tyrosine, phenylalanine and tryptophan in rats with thioacetamide-induced liver encephalopathy. The first group of rats was on protein-free diet and Aminosteril-Hepa (Fresenius FRG)--an amino acids solution with predominance of branched-chain amino acids. The second group of rats received a diet with 1 g/kg b.w. of protein daily. The levels of biochemical indices were analysed 0, 3, 5 and 7 days after liver encephalopathy development. The results of our study indicate a favourable influence of infusion a branched-chain amino acids solution (Aminosteril-Hepa) on the biochemical indices, particularly phenols and alpha-amino nitrogen in experimental liver encephalopathy.
Boroń
P
P
Szpakowicz
T
T
Farbiszewski
R
R
Flisiak
R
R
Nowak
H
H
Pytel
B
B
Zimnoch
L
L
D000596:Amino Acids / Q000008:administration & dosage*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D000641:Ammonia / Q000097:blood; D000818:Animals; D002908:Chronic Disease; D004044:Dietary Proteins / Q000008:administration & dosage*; D006501:Hepatic Encephalopathy / Q000097:blood / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D010288:Parenteral Nutrition; D010636:Phenols / Q000097:blood; D010649:Phenylalanine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013853:Thioacetamide; D014364:Tryptophan / Q000097:blood; D014443:Tyrosine / Q000097:blood
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D004044:Dietary Proteins; D010636:Phenols; C064930:aminosteril-hepa; D013853:Thioacetamide; D014443:Tyrosine; D010649:Phenylalanine; D000641:Ammonia; D014364:Tryptophan
Badania nad wpływem diety bezbiałkowej i stosowania aminokwasów wielorozgałezionych (preparat Aminosteril-Hepa) na wybrane wskaźniki biochemiczne w przewlekłej doświadczalnej encefalopatii watrobowej.