Effect of minaprine on cycloheximide-induced amnesia in mice.
The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnesic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficial effect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Kawashima
K
K
Kameyama
T
T
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000647:Amnesia / Q000139:chemically induced* / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003513:Cycloheximide / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D010830:Physostigmine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology*; D016713:Ritanserin; D012601:Scopolamine / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D010133:p-Chloroamphetamine / Q000494:pharmacology
D010880:Piperidines; D011724:Pyridazines; D013764:Tetrahydronaphthalenes; C006149:minaprine; D016713:Ritanserin; D010133:p-Chloroamphetamine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003513:Cycloheximide; D010830:Physostigmine; D012601:Scopolamine