[ICO-35 monoclonal antibodies to the antigen of acute lymphoblastic leukemia].
ICO-35 monoclonal antibodies (Mabs) were produced following BALB/c mouse immunization with peripheral blood cells from a patient with lymphoid type of chronic myeloid leukemia in blast crisis (SML BC) ICO-35. Mabs detect antigen on CD10-positive cells from patients with acute lymphoblastic leukemia, CML BC, CD10-positive cells of Reh line and are not bound to other cells. Comparative studies of reactivity of ICO-35 and K 503 Mabs to CD10 antigen revealed their similarity. However, in contrast to K503 ICO-35 Mabs do not react with granulocytes.
Baryshnikov
A Iu
AIu
Tupitsyn
N N
NN
Korotkova
O V
OV
Kadagidze
Z G
ZG
Dostot
E
E
Shmidt
M
M
Boumsell
L
L
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D015260:Neprilysin; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin
Monoklonal'nye antitela IKO-35 k antigenu ostrogo limfoblastnogo leĭkoza.