title: Turbulent stresses downstream of porcine and pericardial aortic valves implanted in pigs.
abstract: Because late valve-related complications such as hemolysis and thromboembolic events are considered related to flow disturbances caused by the inserted valve, velocity fields downstream of aortic valve prostheses were studied in pigs. Acute hemodynamic evaluation of size 25-mm porcine and pericardial aortic valve prostheses 1 diameter downstream of the valve ring was performed using dynamic three-dimensional visualization of velocity profiles and spatial distribution of turbulence. Point blood velocity signals obtained with a 1-mm hot-film anemometer needle probe were used to compute Reynolds normal stresses (RNS) by calculation of the turbulent velocity energy of the axial velocity component in the systole. The porcine valves caused a skewed velocity and turbulence profile revealing mean spatial systolic RNS at 70 nm-2 +/- 35 nm-2 (+/- SD). The spatial maximum RNS was 275 +/- 139 nm-2. Corresponding values for the pericardial valves were 20 +/- 11 nm-2 and 72 +/- 46 nm-2. The pericardial valves revealed plug-shaped velocity profiles and turbulent profiles with slightly higher RNS values at the stent posts. From a hemodynamic point of view, these acute studies indicate superiority of the pericardial valves compared to the porcine valves. The turbulent stresses found in this study are of a magnitude that may cause blood corpuscular and endothelial damage.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Skejby Sygehus, Aarhus University Hospital, Denmark.
authors.forename: J M
authors.initials: JM
authors.lastname: Hasenkam
authors.forename: H
authors.initials: H
authors.lastname: Nygaard
authors.forename: E M
authors.initials: EM
authors.lastname: Pedersen
authors.forename: J H
authors.initials: JH
authors.lastname: Ostergaard
authors.forename: P K
authors.initials: PK
authors.lastname: Paulsen
authors.forename: G
authors.initials: G
authors.lastname: Johannsen
mesh_terms: D000818:Animals; D001021:Aortic Valve; D001705:Bioprosthesis; D001783:Blood Flow Velocity / Q000502:physiology; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology*; D006461:Hemolysis; D011183:Postoperative Complications / Q000209:etiology; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013552:Swine; D013927:Thrombosis / Q000209:etiology