Stereochemical studies on the formation of melanin by monophenol monooxygenase.
The oxidation of tyrosine by monophenol monooxygenase (tyrosinase: EC 1.10.3.1) to melanin has been studied by a combination of ultraviolet, circular dichroism, and nuclear magnetic resonance techniques. It is demonstrated that the chiral intermediate (dopachrome) is generated stereoselectively in this enzymic reaction.
Kajiwara
M
M
Kurumaya
K
K
Kohno
Y
Y
Tomita
K
K
Carpenter
A T
AT
D004156:Catechol Oxidase / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000096:biosynthesis*; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet
D008543:Melanins; D004156:Catechol Oxidase