Localization of the atrial natriuretic peptide binding sites in the inner ear tissue--possibly an additional regulating system.
Specific high affinity atrial natriuretic peptide (ANP) binding sites were identified and localized by autoradiography (125J-ANP 1-28) in the inner ear of guinea pigs. ANP is a cardiac hormone known to mediate increased capillary permeability, vasodilation, and natriuresis. Since specific receptors for ANP exist in both eye and brain, possibly playing a role in regulation of fluid and pressure (14, 15), we hypothetized that ANP might be involved also in inner ear fluid dynamics via interaction with other volume/electrolyte balance regulating hormones including vasopressin, renin, and aldosteron. The distribution of ANP receptor in the inner ear tissue appears unequal, which may play a significant role in view of some functional disturbances such as Meniere's disease.
Meyer zum Gottesberge
A
A
Department of Otorhinolaryngology, University of Düsseldorf, FRG.
Lamprecht
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001345:Autoradiography; D001665:Binding Sites; D003051:Cochlea / Q000378:metabolism; D007758:Ear, Inner / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male
D009320:Atrial Natriuretic Factor