Effect of fructose-induced hypertension on the renin-angiotensin-aldosterone system and atrial natriuretic factor.
Studies were performed to examine the effects of a high fructose intake on blood pressure, the renin-angiotensin-aldosterone system, and atrial natriuretic factor in normal rats. Sprague-Dawley rats were fed with either normal rat chow or a fructose-enriched diet for four or seven weeks. High dietary fructose consumption induced hyperinsulinemia and hypertriglyceridemia, and increased the systolic blood pressure by 19 +/- 4 mm Hg (four weeks of diet) and 24 +/- 1 mm Hg (seven weeks of diet), respectively. There were no significant changes in the plasma renin activity at either time. However, an increase in plasma atrial natriuretic factor was noted in rats treated with a high fructose diet for four weeks, and a decrease in plasma aldosterone was found in those rats fed with fructose for a longer period. There was no significant difference in body weight gain between rats fed with fructose-enriched diet and those fed with control diet. These data indicate that the increase in blood pressure associated with a high fructose intake is not due to a direct effect or the renin-angiotensin-aldosterone system.
Hwang
I S
IS
Department of Clinical Laboratory, Provincial Taoyuan General Hospital, Taiwan.
Huang
W C
WC
Wu
J N
JN
Shian
L R
LR
Reaven
G M
GM
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001794:Blood Pressure; D005632:Fructose; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D005632:Fructose; D009320:Atrial Natriuretic Factor