title: Bacterial resistance ATPases: primary pumps for exporting toxic cations and anions.
abstract: Bacterial plasmid resistance systems that maintain low intracellular levels of toxic heavy metals by pumping the substrates out as rapidly as they accumulate sometimes work at the biochemical level as efflux ATPases. The two systems responsible for arsenic and cadmium resistance have recently been sequenced. Comparison of the deduced amino acid sequences with those of better characterized ATPases has revealed certain structural and sequence similarities.
authors.forename: S
authors.initials: S
authors.lastname: Silver
authors.forename: G
authors.initials: G
authors.lastname: Nucifora
authors.forename: L
authors.initials: L
authors.lastname: Chu
authors.forename: T K
authors.initials: TK
authors.lastname: Misra
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000595:Amino Acid Sequence; D001151:Arsenic / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena; D002104:Cadmium / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008954:Models, Biological; D008969:Molecular Sequence Data
chemical_list: D002104:Cadmium; D000251:Adenosine Triphosphatases; D001151:Arsenic