[Amino acid derivatives of 2,6-xylidine and p-aminobenzoic acid. II. Synthesis of derivatives of N-(p-aminobenzoylaminoalkylacyl)-2,6-xylidines and study of their resistance to proteolytic factors].
Syntheses of N-(p-aminobenzoylaminoalkylacyl)-2,6-xylidines are described. The carbodiimide method and the method of mixed anhydrides were employed for the syntheses. Physicochemical properties, yields, data of elementary analysis and IR spectra of eighteen novel compounds are given. Resistance of some obtained compounds to actions of the gastric digestive juice and the intestinal one was tested.
Kwapiszewski
W
W
Pirianowicz-Chaber
E
E
Skulski
L
L
D000814:Aniline Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer / Q000379:methods; D004351:Drug Resistance; D005750:Gastric Juice; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000302:isolation & purification; D010194:Pancreatin / Q000494:pharmacology*; D010434:Pepsin A / Q000494:pharmacology*; D016677:Tocainide
D000814:Aniline Compounds; D016677:Tocainide; C007766:2,6-xylidine; D010194:Pancreatin; D008012:Lidocaine; D010434:Pepsin A
Aminokwasowe pochodne 2,6-ksylidyny i kwasu p-aminobenzoesowego. II. Otrzymywanie pochodnych N-(p-aminobenzoiloaminoalkiloacylo)-2,6-ksylidyn i badanie ich odporności na działanie czynników proteolitycznych.