title: Coagulation changes following hepatic revascularization during liver transplantation.
abstract: The coagulation changes during liver transplantation have been studied in 14 selected patients. Blood usage in all cases was limited to 8.5 liters, and the preoperative coagulation results were only minimally deranged. Bleeding during the operative procedure was easily managed in all cases. Nonetheless, even in this selected group of "low risk" patients, we have demonstrated that during the anhepatic phase and particularly following hepatic revascularization there is activation of both coagulation and fibrinolysis. These findings imply that if bleeding occurs following revascularization, in addition to the use of replacement blood products, treatment should be directed at reducing the consumptive coagulopathy and inhibiting fibrinolysis. We suggest as a first step antithrombin supplementation to maintain activity above 70%, and an antifibrinolytic agent, such as aprotonin, should be considered as adjuncts to therapy at revascularization.
authors.affiliation: Department of Haematology, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
authors.forename: P L
authors.initials: PL
authors.lastname: Harper
authors.forename: R J
authors.initials: RJ
authors.lastname: Luddington
authors.forename: I
authors.initials: I
authors.lastname: Jennings
authors.forename: D
authors.initials: D
authors.lastname: Reardon
authors.forename: M J
authors.initials: MJ
authors.lastname: Seaman
authors.forename: R W
authors.initials: RW
authors.lastname: Carrell
authors.forename: J R
authors.initials: JR
authors.lastname: Klink
authors.forename: M
authors.initials: M
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Rolles
authors.forename: R
authors.initials: R
authors.lastname: Calne
mesh_terms: D000367:Age Factors; D000991:Antithrombins / Q000097:blood; D001777:Blood Coagulation; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005341:Fibrinolysin / Q000097:blood; D005342:Fibrinolysis; D006801:Humans; D008099:Liver / Q000098:blood supply*; D016031:Liver Transplantation; D009926:Organ Preservation; D010958:Plasminogen / Q000378:metabolism; D011517:Prothrombin Time; D013997:Time Factors; D000979:alpha-2-Antiplasmin / Q000378:metabolism
chemical_list: D000991:Antithrombins; D000979:alpha-2-Antiplasmin; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005170:Factor X; D005340:Fibrinogen; D010958:Plasminogen; D005341:Fibrinolysin