Cytohistologic correlation of urothelial lesions secondary to photodynamic therapy.
Qualitative cytologic evaluations of urinary bladder washings were performed on a selected population following photodynamic therapy for recurrent transitional cell carcinoma of the bladder. The seven patients were monitored trimonthly by cystoscopy, multiple biopsies and cytopreparations. Cancers reappeared in two of the five patients who initially responded to therapy. In the remaining two patients, the recurrent neoplasms were therapeutically refractory. Cytology detected recurrent cancer prior to biopsy confirmation and/or cytoscopic identification. Exfoliative cytology was correlated with the histopathology of the concurrent biopsies; a possible source for a false-positive cytodiagnosis was the cellular atypia of reepithelialized bladder mucosa. Dysplasia was not identified cytologically or histologically.
Broghamer
W L
WL
Department of Pathology, University of Louisville School of Medicine, KY 40292.
Parker
J E
JE
Harty
J I
JI
Gilkey
C M
CM
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D003558:Cystoscopy; D017323:Dihematoporphyrin Ether; D005260:Female; D005500:Follow-Up Studies; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010778:Photochemotherapy; D007507:Therapeutic Irrigation; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether