Changes in receptor response by the effect of disease on membrane fluidity.
Currently, changes that occur in receptor function under (patho-) physiological conditions are being investigated. The molecular mechanisms causing the observed variations are largely unknown. It is suggested that the pivotal role of the fluidity of the membrane has been neglected in the literature. It is hypothesized that aberrations in receptor function in diseases that are associated with a concomitant mild oxidative stress can be explained by membrane wavering.
Raber
J
J
Department of Pharmacochemistry, Faculty of Chemistry, Free University, Amsterdam, The Netherlands.
Bast
A
A
D006801:Humans; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000502:physiology*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*
D008563:Membrane Lipids; D010743:Phospholipids; D011956:Receptors, Cell Surface