[Metabolic studies of 5-ethyl-2'-deoxyuridine with liver extract, liver cells and liver cell culture].
5-Ethyl-2'-deoxyuridine (EtUdR) was converted with rat liver extract, rat liver cells and rat liver cell cultures into its metabolites 5-ethyluracil and 5-(1-hydroxyethyl) uracil. The analytical identification of the metabolites as well as the investigation of the biotransformation process was performed by thin layer chromatography, autoradiography and high pressure liquid chromatography.
Buchele
A
A
Firma Robugen GmbHa, Pharmazeutische Fabrik, Esslingen.
Schloz
U
U
Müller-Wellensiek
A
A
Voelter
W
W
D000818:Animals; D001345:Autoradiography; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D003012:Microbial Collagenase; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000378:metabolism
D014020:Tissue Extracts; C022811:edoxudin; D003012:Microbial Collagenase; D003857:Deoxyuridine
Metabolisierungsstudien von 5-Ethyl-2'-desoxyuridin mit Leberextrakt, Leberzellen und Leberzellkulturen.