Binding pattern of [35S]t-butylbicyclophosphorothionate is not altered following electroconvulsive shock treatment in rats.
Single or repeated electroconvulsive shock (ECS) treatment-induced changes in [35S]t-butylbicyclophosphorothionate [( 35S]TBPS) binding patterns in specific regions, i.e., cerebral cortex, cerebellum, hippocampus, and striatum of rat brain were investigated. Specific [35S]TBPS binding in these brain regions was not altered following a single or repeated administration of ECS, nor was the inhibition of [35S]TBPS binding to GABA affected. These observations tend to suggest that the picrotoxin-site on the GABA receptor complex may not be directly involved in electroconvulsive shock.
Kulkarni
S K
SK
Department of Pharmacology, University of Texas Health Science Center, San Antonio 72884-7764.
Ticku
M K
MK
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D001643:Bridged Bicyclo Compounds / Q000378:metabolism*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000378:metabolism*; D004565:Electroconvulsive Therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism* / Q000502:physiology
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D011963:Receptors, GABA-A; C037476:tert-butylbicyclophosphorothionate