Failure of mupirocin-resistant staphylococci to inactivate mupirocin.
Isolates from four UK centres, comprising four Staphylococcus aureus strains and one Staphylococcus epidermidis strain with high-level mupirocin resistance, and one strain each of Staphylococcus aureus and Staphylococcus epidermidis with low-level mupirocin resistance, were assessed for intracellular or extracellular enzymatic alteration of the antibiotic. No change was seen in a number of assays, which included comparative disk diffusion, well diffusion and high-pressure liquid chromatography. Other mechanisms of resistance need to be explored in these isolates.
Cookson
B
B
Department of Microbiology, St. Thomas' Hospital, United Medical School of Guy's Hospitals, London, UK.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial; D005227:Fatty Acids / Q000378:metabolism; D016712:Mupirocin; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000378:metabolism*; D013212:Staphylococcus epidermidis / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D016712:Mupirocin