The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution.
The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.
Acharya
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R
Laboratory of Molecular Biophysics, Oxford, UK.
Fry
E
E
Stuart
D
D
Fox
G
G
Rowlands
D
D
Brown
F
F
D000465:Algorithms; D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000648:ultrastructure*; D005075:Biological Evolution; D002213:Capsid / Q000276:immunology / Q000648:ultrastructure; D003198:Computer Simulation; D008969:Molecular Sequence Data; D010849:Picornaviridae / Q000648:ultrastructure; D014764:Viral Proteins / Q000032:analysis; D014765:Viral Vaccines; D014961:X-Ray Diffraction
D014764:Viral Proteins; D014765:Viral Vaccines