title: Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain.
abstract: CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, California 94305.
authors.forename: A
authors.initials: A
authors.lastname: Wright
authors.forename: J E
authors.initials: JE
authors.lastname: Lee
authors.forename: M P
authors.initials: MP
authors.lastname: Link
authors.forename: S D
authors.initials: SD
authors.lastname: Smith
authors.forename: W
authors.initials: W
authors.lastname: Carroll
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: C
authors.initials: C
authors.lastname: Clayberger
authors.forename: A M
authors.initials: AM
authors.lastname: Krensky
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002051:Burkitt Lymphoma / Q000276:immunology*; D017252:CD3 Complex; D016827:CD8 Antigens; D002461:Cell Line, Transformed; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen; D004854:Herpesvirus 4, Human; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D007130:Immunoglobulin Idiotypes; D016169:Lymphocyte Function-Associated Antigen-1; D011948:Receptors, Antigen, T-Cell