Philadelphia chromosome without breakpoint cluster region rearrangement in a case of Lennert's lymphoma of suppressor phenotype.
A 60-year-old woman presented with diffuse lymphadenopathy. Diagnostic and staging work-up showed that the patient had diffuse small cleaved cell lymphoma (diffuse poorly differentiated lymphocytic lymphoma) with associated histiocytes (lymphoepithelioid cell lymphoma) by the Kiel classification system. Immunohistologic staining showed a T suppressor cell tumour phenotype. Cytogenetic studies revealed the Philadelphia chromosome (Ph1). On DNA studies, the breakpoint cluster region (BCR) gene was not rearranged suggesting that the Ph1 involvement was not identical to that seen in chronic myelogenous leukemia (CML). This case is presented because of the rarity of Ph1 in lymphoid malignancies, particularly in those of T-cell origin, and because of its potentially adverse implications.
Terjanian
T
T
Department of Hematology, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.
Blick
M B
MB
Shtalrid
M
M
Manning
J T
JT
Trujillo
J M
JM
Cabanillas
F
F
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D004247:DNA / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000032:analysis / Q000145:classification / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D010677:Philadelphia Chromosome; D050378:T-Lymphocytes, Regulatory / Q000145:classification*; D014178:Translocation, Genetic
D000945:Antigens, Differentiation, T-Lymphocyte; D004247:DNA