[Polyfructosan and para-aminohippuric acid clearance, comparison of 2 methods for determining glomerular filtration and plasma renal flow].
Glomerular Filtration Rate (GFR) and Renal Plasma Flow (RPF) were measured respectively, Polyfructosan and Para-aminohippuric acid clearances, in 13 patients with different degrees of renal insufficiency. Two different methods were used, the standard method and one without urine collection. The mean GFR (66.4 +/- 27.8 vs. 72.2 +/- 19.0 ml/m, r = 0.74) and RPF (431 +/- 204 vs 490 +/- 188 ml/m, r = 0.76) as well as Filtration Fraction (17.7 +/- 8.3 vs. 16.6 +/- 6.6%) were well correlated. These data show that within the normal range of GRF and RPF the method determining only plasma levels is as reliable as the standard method, giving the advantage to be less troublesome for patients and staff, requiring no bladder catheterization.
Lobo
J
J
Brera
C
C
Soriani
N
N
D000328:Adult; D000368:Aged; D000618:Aminohippuric Acids / Q000493:pharmacokinetics*; D005260:Female; D005630:Fructans / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011134:Polysaccharides / Q000493:pharmacokinetics*; D012079:Renal Circulation; D010130:p-Aminohippuric Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D000618:Aminohippuric Acids; D005630:Fructans; D011134:Polysaccharides; C002938:polyfructosan; D010130:p-Aminohippuric Acid
Clearance del polifruttosano e dell'acido para-aminoippurico, confronto di due metodiche per la determinazione della filtrazione glomerulare e della portata renale plasmatica.