title: Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits.
abstract: Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consistently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?
authors.affiliation: Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey 17033.
authors.forename: D E
authors.initials: DE
authors.lastname: Palm
authors.forename: L C
authors.initials: LC
authors.lastname: Keil
authors.forename: J W
authors.initials: JW
authors.lastname: Sassani
authors.forename: W B
authors.initials: WB
authors.lastname: Severs
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D009320:Atrial Natriuretic Factor