Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor.
A case of Wilms' tumor in an adult is reported, showing, by restriction fragment length polymorphism analysis of somatic and tumor DNA, the loss of alleles from the short arm of chromosome 11. Loss of alleles in this region has previously been reported in childhood Wilms' tumor. The findings of this study indicate that adult Wilms' tumor and childhood Wilms' tumor may share a common pathogenic pathway. These results may also be useful in differentiating between Wilms' tumor and renal cell carcinoma or sarcoma in adults when the histologic findings are unclear.
Kozman
H M
HM
Queensland Institute of Medical Research, Herston, Brisbane, Australia.
Clarke
J M
JM
Little
M H
MH
Smith
P J
PJ
D000328:Adult; D000483:Alleles; D002880:Chromosomes, Human, Pair 11; D011905:Genes, ras; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D009396:Wilms Tumor / Q000209:etiology / Q000235:genetics*