Decreases of vascular hypertrophy in four different types of arteries in spontaneously hypertensive rats.
The goal of the present study was to describe the relative extent of vascular hypertrophy in four different types of arteries (coronary, renal, carotid, and mesenteric) of spontaneously hypertensive rats (SHR) and to evaluate the effects of long-term treatment with cilazapril, a new long-acting angiotensin-converting enzyme inhibitor on this vascular hypertrophy. For this purpose, a group of spontaneously hypertensive rats treated for four months with cilazapril (10 mg/kg orally) was compared with a group of spontaneously hypertensive rats treated with placebo. Another group of Wistar Kyoto (WKY) rats treated with placebo was used as a reference. At the end of the treatment period, the rats were perfused-fixed and morphometry of the carotid, renal, mesenteric and coronary arteries was performed. Vascular hypertrophy (increase of the thickness of the medial layer) was present in the four different types of arteries in a similar extent. Cilazapril normalized completely the arterial wall thickness:diameter ratio in the four different types of arteries. Further studies are required to determine whether this effect of cilazapril was due to the decrease of arterial blood pressure or to an effect of cilazapril on growth factors such as angiotensin II.
Clozel
J P
JP
Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Kuhn
H
H
Hefti
F
F
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology*; D017315:Cilazapril; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology*; D006973:Hypertension / Q000473:pathology*; D006984:Hypertrophy; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000473:pathology*; D010919:Placebos; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012077:Renal Artery / Q000187:drug effects / Q000473:pathology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D010919:Placebos; D011724:Pyridazines; D017315:Cilazapril