Laboratory detection of the early stages of diabetic nephropathy.
Three laboratory indicators of impaired renal function (microalbuminuria (MA), N-acetyl-beta-glucosaminidase (NAG), beta-2-microglobulinaemia (beta-2-M)) were studied in sixty diabetics of type 1. 10 times higher MA levels were found in a subgroup of diabetics with identifiable diabetic retinopathy (DR). In a subgroup of diabetics with normal values of excreted albumin the mean MA value was significantly higher than in those who had already contracted DR. Pathological levels of NAG and beta-2-M were mostly seen in those patients who also had pathological MA results. In only four cases were increased NAG or beta-2-M values as the first and only pathological parameter indicative of possible renal involvement due to diabetic nephropathy.
Perusicová
J
J
Skrha
J
J
Márová
E
E
Skachová
J
J
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000368:Aged; D000419:Albuminuria; D003928:Diabetic Nephropathies / Q000175:diagnosis; D003929:Diabetic Neuropathies / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D001613:beta 2-Microglobulin / Q000032:analysis
D001613:beta 2-Microglobulin; D000118:Acetylglucosaminidase