Clonal origin of recurrent hepatocellular carcinomas.
Recurrence of hepatocellular carcinoma after treatment is frequent. To study the clonal origin of the recurrent tumors, we examined five pairs of hepatocellular carcinomas resected from individual hepatitis B surface antigen carriers. Using integrated hepatitis B virus DNA as a marker, tumor clonality was determined by Southern blot analysis. In 2 cases the second tumor contained the same integrated viral DNA as the first one. In the other 3 cases, the clonality of the second cancer differed. We conclude that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.
Chen
P J
PJ
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.
Chen
D S
DS
Lai
M Y
MY
Chang
M H
MH
Huang
G T
GT
Yang
P M
PM
Sheu
J C
JC
Lee
S C
SC
Hsu
H C
HC
Sung
J L
JL
D001483:Base Sequence; D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local
D004279:DNA, Viral