[Studies on the possible causes of decreasing NK cell activity in tumor-bearing mice. I. The number of NK cells in the spleens of tumor-bearing mice is higher than that in normal mice].
In studies of viral immunotherapy of cancer, we found that NK cell activity in tumor-bearing mice was usually below the normal level, a universal phenomenon in tumor-bearing animals and patients. Our data show that the depressed NK cell activity in tumor-bearing mice was not due to a decrease of NK cell number. The percentage of NK cells in the spleens of tumor-bearing mice was much higher than that in normal mice. Using morphological and 3H-TdR uptake methods, we found that there were many NK blast cells in the spleens of tumor-bearing mice, and blastogenesis was sustained up to the day of death.
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D000818:Animals; D007694:Killer Cells, Natural / Q000276:immunology*; D007941:Leukemia P388 / Q000276:immunology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000473:pathology