title: Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis.
abstract: 1. Plasma concentrations of acitretin and its metabolite (13-cis acitretin) were measured in six patients on haemodialysis and six subjects without renal failure following a single oral dose of 50 mg of acitretin. 2. The mean areas under the plasma concentration vs time curves of acitretin and its metabolite were about 50% lower in patients on haemodialysis. 3. No retinoids were detectable in the dialysate.
authors.affiliation: Medizinische Universitätspoliklinik, Bern, Switzerland.
authors.forename: A E
authors.initials: AE
authors.lastname: Stuck
authors.forename: C J
authors.initials: CJ
authors.lastname: Brindley
authors.forename: A
authors.initials: A
authors.lastname: Busslinger
authors.forename: F J
authors.initials: FJ
authors.lastname: Frey
mesh_terms: D017255:Acitretin; D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D014212:Tretinoin; D017255:Acitretin