[Change in carbohydrate metabolism, secretion of insulin and glucagon in normoglycemic rats during administration of various doses of nicotinamide].
Development of hypoglycemia, a slight decrease in concentration of glucagon in blood as well as increase in activity of malate-and glucose-6-phosphate dehydrogenases in liver cytosol were detected in rats injected subcutaneously with nicotinamide at a dose of 31.25 mg/kg 6 hrs before decapitation. Increase of the single dose up to 125 mg/kg caused hypoglycemia, distinct increase in concentration of insulin and glucagon in blood plasma simultaneously with a pronounced inhibition of the enzymatic activity in liver tissue. Effect of nicotinamide on carbohydrate metabolism appears to have a dissimilar character depending on the drug dose: its small doses accelerated utilization and oxidation of glucose but did not affect the secretion of insulin and glucagon.
Krylov
Iu F
IuF
Kononenkko
T L
TL
Smirnov
P A
PA
Tigranian
R A
RA
Kalita
N F
NF
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009536:Niacinamide / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D009243:NAD; D009536:Niacinamide; D009249:NADP; D005934:Glucagon; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Izmenenie uglevodnogo obmena, sekretsii insulina i gliukagona u normoglikemicheskikh krys pri vvedenii razlichnykh doz nikotinamide.