Protein S-100 immunostaining as a diagnostic tool for DMBA-induced melanotic lesions.
In the present study we demonstrate immunohistochemically the presence of S-100 protein in numerous melanotic and amelanotic lesions (benign, premalignant and malignant) induced in albino guinea-pigs on topical application of the carcinogen. Positive staining was also present in all their amelanotic metastases. We reiterate the value of this stain in the diagnosis of melanomas, in particular amelanotic melanomas.
Gómez
S
S
Department of Pathology, Faculty of Medicine, University of Murcia, Spain.
Vicente
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V
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D008546:Melanoma, Experimental / Q000139:chemically induced / Q000473:pathology*; D016612:Paraffin Embedding; D009418:S100 Proteins / Q000276:immunology*; D016707:Tissue Fixation
D009418:S100 Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene