title: Neuronal antinuclear antibodies in a patient with Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma.
abstract: A patient with small-cell lung carcinoma and the Lambert-Eaton myasthenic syndrome had circulating neuronal antinuclear antibodies. Serum stained the nuclei of all neurons in sections of human brain and identified a closely spaced group of 33-39 kDa proteins in immunoblots of human neuronal nuclei. These autoantibodies are indistinguishable from those recently identified in patients with paraneoplastic subacute sensory neuronopathy.
authors.affiliation: Department of Neurology, University of Alabama, Birmingham 35294.
authors.forename: E J
authors.initials: EJ
authors.lastname: Dropcho
authors.forename: C
authors.initials: C
authors.lastname: Stanton
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009474:Neurons / Q000276:immunology*; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear