[Comparison studies on pharmacological properties of injectio gastrodia elata, gastrodin-free fraction and gastrodin].
Injectio Gastrodia elata showed sedative effect on central nervous system with decrease of spontaneous motor activity and a prolonged pentobarbital sleeping time in mice. After administration of injectio Gastrodia, mice were found to be more resistant to hypoxia and nutrient blood flow in cardiac muscle of mice was markedly increased. Besides, It also showed effect of injectio on the croton-oil-induced mouse ear inflammation. The gastrodin-free fraction showed similar but weaker effects as the injectio while no effect was observed of gastrodin in mice. The results show that gastrodin is one of the main constituents of Gastrodia elata, but not the active one.
Huang
J H
JH
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006993:Hypnotics and Sedatives; D000860:Hypoxia / Q000517:prevention & control; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D006993:Hypnotics and Sedatives; C045345:gastrodin