[Comparative analysis of pregnancy proteins and regulation of the functional activity of T-suppressors in pregnancy].
The relationship between the pregnancy specific proteins (SP1, SP3) and the functional activity of ConA-induced T-suppressors has been studied during normal gestation. There were a positive correlation between the activity of T-suppressors and the level of SP1 during 8-28 weeks of gestation; between the activity of T-suppressors and the level of SP3 during 8-36 weeks, especially during 29-36 weeks of gestation. It was shown that a progressive accumulation of these proteins apparently necessary for the formation a suppression's dominant in the condition of the immunoregulatory branches during gestation. These findings suggest that SP1 and SP3 as a natural endogenous immunoregulators may play an important role in reproductive strategy of human gestation.
Chernyshov
V P
VP
Valetskiĭ
V L
VL
Radysh
T V
TV
D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D011247:Pregnancy / Q000276:immunology*; D011257:Pregnancy Proteins / Q000032:analysis*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D011257:Pregnancy Proteins; D003208:Concanavalin A
Sravnitel'nyĭ analiz belkov beremennosti v reguliatsii funktsional'noĭ aktivnosti T-supressorov pri gestationnom protsesse.