[Enzyme activity of adenosine metabolism in human natural killers (NK cells) during the activation and suppression of their cytotoxic activity].
Experiments in vitro were made to study adenosine deaminase (ADA) and 5'-nucleotidase (5-N) activity in NK after their treatment with interferon inductor--Newcastle disease virus (NDV) or with prostaglandin E2 (PGE2). It has been established that treatment of human NK with NDV leads to increasing of their cytotoxic activity (CTA), which is accompanied by rising of ADA activity and reducing of 5-N activity in these cells. Decrease of CTA under the influence of PGE2 occurs together with reduction of ADA activity and increase of 5-N activity in human NK. Changes in NK activity under the influence of various exogenous or endogenous factors may be due to the modification of activity of adenosine metabolism enzymes in these cells.
Umanskiĭ
V Iu
VIu
Kliuchareva
T E
TE
Matveeva
V A
VA
D015720:5'-Nucleotidase; D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007369:Interferon Inducers; D007694:Killer Cells, Natural / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology; D009522:Newcastle disease virus; D009700:Nucleoside Deaminases / Q000378:metabolism*; D009708:Nucleotidases / Q000378:metabolism*; D014762:Viral Interference
D007369:Interferon Inducers; D009708:Nucleotidases; D015720:5'-Nucleotidase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine; D015232:Dinoprostone
Aktivnost' fermentov obmena adenozina v estestvennykh killerakh (NK-kletkakh) cheloveka v usloviiakh aktivatsii i podavleniia ikh tsitotoksicheskoĭ aktivnosti.