Toxicity of fenclor 42 in mice: effects on immunocompetent cells.
The aim of this study is to evaluate the effects of Fenclor 42 (a mixture of trichlorobiphenyls) on the immune system. A prolonged administration of this compound to CD2F1 mice resulted in a reduction of relative spleen and thymus weight according to the dose. Furthermore, spleen weights, total number of splenocytes and relative spleen weights decreased significantly also following a single treatment with 0.5 g/kg or 1 g/kg of Fenclor 42. An analysis of the functional activity of splenocytes pointed out that proliferative response to mitogens was also inhibited. Splenic parameters returned to normal values within 5 days after a single treatment and between 8 and 15 days after a subchronic administration. The functional activity of splenocytes was restored between day +5 and day +8 according to the different schedules of treatment. On the contrary, natural killer cell (NK) activity was never affected by Fenclor 42. Studies are in progress to elucidate the intimate mechanism of the toxicity of Fenclor 42 on immunocompetent cells.
Franco
P
P
Dept. of Pharmacology, School of Medicine, University of Milan, Italy.
Marelli
O
O
Canti
G
G
Ricci
L
L
Prandoni
N
N
Nicolin
A
A
D000818:Animals; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects
D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D011078:Polychlorinated Biphenyls