Adoptive transfer of early and late delayed-type hypersensitivity reactions mediated by human T cells.
Human T cells activated by antigen in vitro mediated both the 2-hour and 24-hour phases of delayed-type hypersensitivity (DTH) when transferred into the mouse footpad. The passively transferred human DTH was similar to murine DTH by kinetics, vasoactive amine dependence, and histologic criteria. These results offer a functional assay for determining whether human T cells are activated by viral or tumor antigens.
Trial
J
J
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
D000818:Animals; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007116:Immunization, Passive; D007700:Kinetics; D008213:Lymphocyte Activation; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D014183:Transplantation, Heterologous
D012702:Serotonin Antagonists; D012701:Serotonin