[Lack of effect of therapy with LHRH analogs, alone or associated with flutamide, on prolactin levels in advanced prostatic carcinoma].
Fourteen patients with advanced prostatic carcinoma have been considered. Some were treated with goserelin depot and some with goserelin depot plus flutamide; basal and stimulated PRL were studied in the two groups before and after two months treatment in order to verify a possible interference with prolactin secretion which seems to have a trophic and stimulating effect on neoplastic tissue growth. Basal PRL levels and levels after TRH infusion haven't shown significant variations between the two groups of patients. Even if relative to a short time, our results exclude PRL increase, which might be suspected with these drugs, and at last confirm the effectiveness of this treatment (LHRH analogs plus flutamide) in prostatic carcinoma.
Banchini
A
A
Zavaroni
D
D
Tarditi
E
E
Cortellini
P
P
Ziveri
M
M
Polotti
R
R
Stefani
F
F
Valenti
G
G
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000813:Anilides / Q000627:therapeutic use*; D002064:Buserelin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005485:Flutamide / Q000627:therapeutic use*; D017273:Goserelin; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D000813:Anilides; D003692:Delayed-Action Preparations; D017273:Goserelin; D013973:Thyrotropin-Releasing Hormone; D005485:Flutamide; D011388:Prolactin; D002064:Buserelin
Mancanza di effetti della terapia con analogo di LHRH, solo o associato a flutamide, sui livelli di PRL nel carcinoma prostatico in stadio avanzato.