Effect of some drugs acting at the central-type benzodiazepine receptors on blood glucose in mice.
1. The effects of some drugs acting at the central-type benzodiazepines receptors on blood glucose levels in mice were studied. 2. Clonazepam, injected intraperitoneally in doses of 0.625-5 mg, produced a dose-dependent increase in blood glucose 30 min after administration. 3. The hyperglycaemic effect of clonazepam (2.5 mg/kg, i.p.) was dose-dependently reduced by Ro 15-1788 (10-40 mg/kg, i.v.), a benzodiazepine antagonist. 4. Ro 5-3663, a GABA antagonist which may act at the picrotoxinin site, produced a significant increase in blood glucose (5 or 10 mg/kg, i.p.); however, when given together with clonazepam (2.5 mg/kg, i.p.) attenuation of the hyperglycaemic effect was observed. 5. Pk 8165, a partial agonist, lacked an effect on blood glucose over the dose range of 5-20 mg/kg, i.p. but caused a slight increase in blood glucose in a dose of 40 mg/kg, i.p.
Najim
R A
RA
Department of Pharmacology, College of Medicine, Baghdad University, Iraq.
al-Essa
L Y
LY
al-Jawad
F H
FH
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism*; D002998:Clonazepam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005442:Flumazenil / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D011804:Quinolines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*
D001570:Benzodiazepinones; D001786:Blood Glucose; D011804:Quinolines; D011963:Receptors, GABA-A; D005442:Flumazenil; D002998:Clonazepam; C022193:Ro 5-3663; C030078:pipequaline