The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27).
Complementary DNA and genomic clones corresponding to the gene for the common acute lymphoblastic leukemia antigen (CALLA) were used to investigate the genetic structure and location of the CALLA locus. The gene, which encodes a 100-kDa type II transmembrane glycoprotein, appears to be a single copy locus of greater than 45 kb which is not rearranged in malignancies expressing cell surface CALLA. Cell hybrid analysis indicates that the CALLA-related DNA sequences are found on human chromosome 3. In situ hybridization studies reveal the regional location of the CALLA locus to be 3q21-27.
Barker
P E
PE
Department of Biochemistry, University of Alabama, Birmingham 35294.
Shipp
M A
MA
D'Adamio
L
L
Masteller
E L
EL
Reinherz
E L
EL
D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping / Q000379:methods; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D006822:Hybrid Cells / Q000032:analysis; D008677:Metaphase; D051379:Mice; D015260:Neprilysin; D009693:Nucleic Acid Hybridization; D011990:Receptors, Transferrin / Q000235:genetics
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D011990:Receptors, Transferrin; D015260:Neprilysin