5-Hydroxytryptamine contracts human coronary arteries predominantly via 5-HT2 receptor activation.
5-Hydroxytryptamine (5-HT) caused contractions of human isolated epicardial coronary arteries which were markedly antagonised by ketanserin (10 nM-1 microM). The antagonism was not competitive. The selective 5-HT1-like receptor agonist, GR43175, caused only small, ketanserin-resistant contractions. These results suggest that the predominant contractile effect of 5-HT in human isolated large coronary arteries is mediated via 5-HT2 receptors but that, in addition, 5-HT1-like receptors contribute to some degree to this response in vitro.
Connor
H E
HE
Department of Cardiovascular Pharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
Feniuk
W
W
Humphrey
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PP
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000328:Adult; D002648:Child; D003331:Coronary Vessels / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology; D018170:Sumatriptan
D007211:Indoles; D011450:Prostaglandin Endoperoxides, Synthetic; D011985:Receptors, Serotonin; D013449:Sulfonamides; D012701:Serotonin; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D018170:Sumatriptan; D007650:Ketanserin