The density of cholinergic and alpha and beta adrenergic receptors in the normal and hyper-reflexic human detrusor.
The density of cholinergic and of alpha and beta adrenergic receptors was measured in samples of normal and hyper-reflexic human detrusor muscle. There was a significant reduction in the density of cholinergic receptors and a significant increase in the density of alpha adrenergic receptors in the hyper-reflexic samples as compared with normal. There was no difference between the two groups in the density of beta adrenergic receptors.
Restorick
J M
JM
Department of Surgery, Guy's Hospital, London.
Mundy
A R
AR
D005260:Female; D006801:Humans; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D011950:Receptors, Cholinergic / Q000032:analysis*; D012021:Reflex, Abnormal / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*; D001745:Urinary Bladder Diseases / Q000378:metabolism*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic