Glycosaminoglycan (GAG) level and activities of certain enzymes of GAG metabolism in Culex quinquefasciatus and Setaria digitata.
Significant differences were observed in GAG metabolism of S. digitata and one of its intermediate vectors, C. quinquefasciatus. Distribution of different components such as hyaluronic acid, heparin-sulphate, chondroitin-4-sulphate, chondroitin-6-sulphate, dermatan sulphate and heparin was comparable in both. However, there were quantitative differences; the difference was marked in the activity of enzymes of GAG metabolism in presence and absence of diethylcarbamazine (DEC) a known antifilarial drug. While the activities of beta-galactosidase and beta-N-acetyl glucosaminidase of S. digitata systems showed an inhibition of 96.5 and 92.6% respectively, in the Culex systems they showed an inhibition of 93.3% and an activation of 18% respectively. The differences clearly indicate the existence of basic differences in GAG metabolism of vector and parasite.
Mathai
A
A
Devi
K S
KS
Raj
R K
RK
D000118:Acetylglucosaminidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D003465:Culex / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D004049:Diethylcarbamazine / Q000494:pharmacology; D005260:Female; D005370:Filarioidea / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D005696:Galactosidases / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism*; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D006025:Glycosaminoglycans; D005696:Galactosidases; D006596:Hexosaminidases; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase; D004049:Diethylcarbamazine