Acute damage of gastroduodenal mucosa by acetylsalicylic acid: no prolonged protection by antacids.
Twenty healthy volunteers participated in a double-blind, crossover study to evaluate endoscopically whether low-dose antacids have any prolonged and pH-independent protective capacity against gastroduodenal mucosal damage induced by acetylsalicylic acid. Antacid or placebo one tablet q.d.s. was given for 1.5 days. Acetylsalicylic acid (1.5 g) was administered 3 h after the last dose of antacid/placebo, and gastroscopy was performed 1 h thereafter. Thirteen of 20 subjects showed a decrease in total damage with antacids as compared with placebo, but the difference did not reach statistical significance. Thus, protection by antacids against acetylsalicylic acid-induced gastric mucosal lesions could not be documented at a time when intragastric pH presumably had returned to normal.
Berstad
K
K
Medical Department, Haukeland University Hospital, Bergen, Norway.
Haram
E M
EM
Weberg
R
R
Berstad
A
A
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D001241:Aspirin / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D004311:Double-Blind Method; D004386:Duodenum / Q000187:drug effects; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D000863:Antacids; D001241:Aspirin