Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings.
A patient with progressive supranuclear palsy demonstrated a region-specific decrease in T2 signal during high-field-strength brain magnetic resonance imaging. At autopsy the T2-signal hypointensity was found to correspond topographically to increased deposition of ferric iron. The potential clinical, radiologic, and pathophysiologic implications of these findings are discussed.
Coffey
C E
CE
Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
Alston
S
S
Heinz
E R
ER
Burger
P C
PC
D001921:Brain / Q000473:pathology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology; D009460:Neurologic Examination; D009474:Neurons / Q000473:pathology; D009483:Neuropsychological Tests; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D007501:Iron