title: [Frequency-related blocking of sodium channels in the membrane of isolated rat cardiomyocytes by the calcium antagonist verapamil].
abstract: Use-dependent blocking of sodium current in the membrane of single rat cardiomyocytes by verapamil (in the concentration range of 5-50 mumol/l) has been observed. The data obtained suggest that verapamil binding with sodium channels which are in the open or inactivated state underlies suppression of sodium current.
authors.forename: V I
authors.initials: VI
authors.lastname: Pidoplichko
authors.forename: A N
authors.initials: AN
authors.lastname: Verkhratskiĭ
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009206:Myocardium / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D015222:Sodium Channels; D014700:Verapamil
vernacular_title: Chastotno-zavisimoe blokirovanie natrievogo toka membrany izolirovannykh kardiomiotsitov krys kal'tsievym antagonistom verapamilom.