Thrombolysis of graft occlusion using high dose urokinase. An alternative to surgical treatment?
Two cases of acute leg ischemia from unilateral occlusion of an aorto-bifemoral graft, treated with high-dose urokinase intra-arterial infusion, are reported. This therapy allowed identification of the cause of thrombosis, recanalization of the graft and planning of reoperation. Indications for intra-arterial thrombolytic therapy and advantages of urokinase vs streptokinase are discussed.
Mingoli
A
A
I Istituto di Clinica Chirurgica, Università La Sapienza, Roma.
Di Marzo
L
L
Sciacca
V
V
Castrucci
M
M
Pavone
P
P
Farina
C
C
Tamburelli
A
A
Cavallaro
A
A
D000368:Aged; D000714:Anastomosis, Surgical; D000800:Angioplasty, Balloon; D001012:Aorta, Abdominal / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012086:Reoperation; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
D014568:Urokinase-Type Plasminogen Activator