[Myocardial infarct in rats: right ventricular hypertrophy as a criterion of postinfarct left ventricular heart failure].
The course of experimental myocardial infarction was accompanied by the growth response of the right ventricle (RV) in some rats. Rats with RV hypertrophy unlike ones without RV hypertrophy had depressed cardiac contraction force and velocity at rest as well as a minimal capacity to respond to functional stress. Dibunol (butylhydroxytoluene, 30 mg/kg) prevented the depression of cardiac contractility and RV growth. RV hypertrophy in the rats following left coronary artery ligation is the consequence of the left ventricle pump failure and resultant pulmonary hypertension. RV hypertrophy may be proposed as an index of postinfarct heart failure and its reduction as an index of the cardioprotective effect of various pharmacological interventions.
Konorev
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002084:Butylated Hydroxytoluene
Infarkt miokarda u krys: gipertrofiia pravogo zheludochka serdtsa kak kriteriĭ postinfarktnoĭ levozheludochkovoĭ serdechnoĭ nedostatochnosti.