Blastocyst development on days 10 or 14 after consumption of zearalenone by sows on days 7 to 10 after breeding.
Sixteen primiparous sows were bred and fed either a control ration (n = 8) or a diet containing purified zearalenone (n = 8; 1 mg/kg of body weight) from days 7 to 10 after breeding. On day 7 after breeding, the jugular vein of each sow was cannulated and blood was collected at 20-minute intervals for 4 hours before feeding and 4 hours after feeding. On day 10 after breeding, blood samples were collected from 4 control sows and 4 zearalenone-fed sows at 20-minute intervals for 4 hours before collection of blastocysts. A similar blood sampling schedule was followed for the remaining 4 control and 4 zearalenone sows on day 14 after breeding. On day 10 after breeding, spherical blastocysts were recovered from all control sows and from 3 of 4 zearalenone-treated sows. Average diameter of blastocysts from zearalenone-treated sows were similar to that of control sows. On day 14 after breeding, blastocysts were recovered from all control sows and 3 of 4 zearalenone-treated sows. Blastocysts from the control sows were filamentous, whereas blastocysts from zearalenone-treated sows were fragmented and contained foci of necrosis. Incidence of luteinizing hormone (LH) secretory spikes per sow was less (P less than 0.01) in zearalenone-treated sows (0.25 +/- 0.25/4 h) than control sows (1.75 +/- 0.25/4 h) on day 10 after breeding. Incidence of follicle-stimulating hormone (FSH) secretory spikes was similar (P = 0.45) among treatments on days 7, 10, and 14 after breeding.(ABSTRACT TRUNCATED AT 250 WORDS)
Diekman
M A
MA
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.
Long
G G
GG
D000284:Administration, Oral; D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000662:veterinary; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D012118:Resorcinols / Q000633:toxicity*; D013552:Swine / Q000502:physiology*; D013997:Time Factors; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity*
D012118:Resorcinols; D011374:Progesterone; D015025:Zearalenone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone