Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure.
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
Konishi
M
M
Bristol-Myers Research Institute, Ltd., Tokyo Research Center.
Nishio
M
M
Saitoh
K
K
Miyaki
T
T
Oki
T
T
Kawaguchi
H
H
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000032:analysis; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003515:Cycloleucine / Q000302:isolation & purification / Q000494:pharmacology / Q000031:analogs & derivatives; D005285:Fermentation
D000935:Antifungal Agents; D003515:Cycloleucine; C065594:cispentacin