title: Platelet-derived growth factor (PDGF) in type 1 diabetes mellitus.
abstract: In 10 patients with type 1 diabetes mellitus, platelet-derived growth factor (PDGF) was assessed using an in vitro assay based on the stimulation of DNA synthesis in the 3T3 mouse fibroblast cell line. beta-Thromboglobulin (beta-TG) was used as an index for platelet alpha-granules content. Platelet beta-TG content and PDGF were markedly decreased in diabetic patients while plasma beta-TG was increased as compared with control subjects. In diabetic patients, a significant negative correlation was found between plasma beta-TG level and beta-TG total platelet content, associated with a significant positive correlation between platelet beta-TG content and PDGF. These results suggest that PDGF release might be increased in diabetic subjects. This may account in part for the cell proliferation observed in diabetic angiopathy.
authors.affiliation: Department of Diabetology, Hôpital Lariboisiere, Paris, France.
authors.forename: P J
authors.initials: PJ
authors.lastname: Guillausseau
authors.forename: E
authors.initials: E
authors.lastname: Dupuy
authors.forename: M C
authors.initials: MC
authors.lastname: Bryckaert
authors.forename: J
authors.initials: J
authors.lastname: Timsit
authors.forename: P
authors.initials: P
authors.lastname: Chanson
authors.forename: G
authors.initials: G
authors.lastname: Tobelem
authors.forename: J P
authors.initials: JP
authors.lastname: Caen
authors.forename: J
authors.initials: J
authors.lastname: Lubetzki
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000097:blood*; D001620:beta-Thromboglobulin / Q000378:metabolism
chemical_list: D010982:Platelet-Derived Growth Factor; D001620:beta-Thromboglobulin