Effect of dietary fibre on the mutagenicity and distribution of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).
Female BALB/c mice were fed either a fibre-free diet or one supplemented with 30% wheat-bran for 5 weeks. The ability of these mice to convert MeIQ to a bacterial mutagen in vivo was determined using intrasanguinous host-mediated bacterial mutation assays. Less mutagenic activity was detected in the livers of mice fed the bran-supplemented diet compared with those fed the fibre-free diet. Subsequent experiments demonstrated that the effect of brain was not due to modifications in hepatic metabolism, but to changes in uptake of MeIQ from the gastrointestinal tract.
Howes
A J
AJ
British Industrial Biological Research Association, Carshalton, Surrey, Great Britain.
Rowland
I R
IR
Lake
B G
BG
Alldrick
A J
AJ
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D004043:Dietary Fiber / Q000502:physiology*; D005753:Gastric Mucosa / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008862:Microsomes, Liver / Q000378:metabolism; D009154:Mutation / Q000187:drug effects*; D011804:Quinolines / Q000493:pharmacokinetics* / Q000633:toxicity; D014018:Tissue Distribution; D014908:Triticum
D004043:Dietary Fiber; D011804:Quinolines; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline