Seroepidemiology of human herpesvirus 6 infection in normal children and adults.
Sera from normal subjects were examined for reactivity to human herpesvirus 6 (HHV-6) by the anticomplement immunofluorescence test. Of a total of 179 serum specimens from donors aged from under 10 to 59 years, 141 specimens showed positive reactivity against HHV-6. The positive rate was 70 to 83% for all age groups, and there were no substantial differences in the positive rates. Sera from younger children aged from 0 to 21 months were then examined in detail. The antibody-positive rate of children aged from 0 to 5 months decreased from 52 to 5%, but it gradually increased by 12 months. Almost all children had the antibody against this virus after 13 months of age.
Okuno
T
T
Department of Virology, Osaka University, Japan.
Takahashi
K
K
Balachandra
K
K
Shiraki
K
K
Yamanishi
K
K
Takahashi
M
M
Baba
K
K
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000145:classification / Q000276:immunology*; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D014481:United States
D000914:Antibodies, Viral