title: Rapid determination of the benzodiazepine antagonist flumazenil, Ro 15-1788, by high performance liquid chromatography.
abstract: A sensitive (2 ng/mL) and specific method for the determination of the benzodiazepine antagonist Ro 15-1788 or flumazenil is described. Following a simple extraction, the compound is analyzed by reversed phase high performance liquid chromatography (HPLC) and detection at 245 nm. The method was applied to plasma specimens collected from patients receiving a single dose of this drug.
authors.affiliation: Laboratoire de Pharmacocinétique et Toxicocinétique, CHU TIMONE, Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Bun
authors.forename: V
authors.initials: V
authors.lastname: Duplan
authors.forename: P
authors.initials: P
authors.lastname: Crevat-Pisano
authors.forename: M
authors.initials: M
authors.lastname: Llurens
authors.forename: A
authors.initials: A
authors.lastname: Durand
mesh_terms: D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D002851:Chromatography, High Pressure Liquid; D005442:Flumazenil / Q000032:analysis*; D006801:Humans; D011786:Quality Control
chemical_list: D001569:Benzodiazepines; D005442:Flumazenil