Altered glycosylation of surface glycoproteins in tumor cells and its clinical application.
Appearance of large Asn-linked sugar chains in the surface glycoprotein is one of the most widely found phenomena in malignant cells and is called the Warren-Glick phenomenon. Comparative study of the sugar chain structures of the surface glycoproteins of cultured cells and their malignant transformants revealed that the altered glycosylation is induced by enhancement of N-acetyl-glucosaminyltransferase V. The change seems to be highly correlated with the metastatic potential of tumor cells.
Kobata
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Department of Biochemistry, University of Tokyo, Japan.
D000818:Animals; D001216:Asparagine / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis / Q000378:metabolism / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002472:Cell Transformation, Viral; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005964:Glucosyltransferases / Q000378:metabolism; D006031:Glycosylation; D008562:Membrane Glycoproteins / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D017351:N-Acetylglucosaminyltransferases; D009362:Neoplasm Metastasis
D008562:Membrane Glycoproteins; D001216:Asparagine; D005964:Glucosyltransferases; D017351:N-Acetylglucosaminyltransferases; C037649:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase