Effects of combined receptor antagonists of leukotriene D4 (LTD4) and platelet-activating factor (PAF) on rhesus airway responses to LTD4, PAF and antigen.
Rhesus monkeys with IgE-mediated asthmatic-type responses to Ascaris suum antigen were pretreated with a combination of 2 receptor antagonists to leukotriene D4 (LTD4) and platelet-activating factor (PAF). This combination of anti-LTD4 and anti-PAF was shown to inhibit airway responses to either LTD4 or PAF in separate experiments in these Ascaris airway-reactive animals. When the same combination of LTD4 and PAF receptor antagonists was used to pretreat the same animal prior to aerosol challenge with Ascaris antigen we could not demonstrate inhibition of the antigen-induced airway response. Thus, combined receptor blockade for LTD4 and PAF did not alter IgE-mediated acute airway responses to antigen in this species. We review the current status of rhesus asthma and LTD4 and PAF receptor antagonist activity in this model.
Patterson
R
R
Department of Medicine, Northwestern University Medical School, Chicago, Ill.
Harris
K E
KE
Bernstein
P R
PR
Krell
R D
RD
Handley
D A
DA
Saunders
R N
RN
D000818:Animals; D001200:Ascaris / Q000276:immunology; D001249:Asthma / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D007073:Immunoglobulin E / Q000276:immunology; D007191:Indazoles / Q000627:therapeutic use*; D008253:Macaca mulatta; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins; D011720:Pyrazoles / Q000627:therapeutic use*; D011806:Quinolinium Compounds / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000187:drug effects; D043562:Receptors, G-Protein-Coupled; D011971:Receptors, Immunologic / Q000187:drug effects; D018077:Receptors, Leukotriene; D013189:SRS-A / Q000037:antagonists & inhibitors*
D007191:Indazoles; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011720:Pyrazoles; D011806:Quinolinium Compounds; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011971:Receptors, Immunologic; D018077:Receptors, Leukotriene; D013189:SRS-A; C039351:platelet activating factor receptor; C054217:ICI 198615; C050531:SRI 63-441; D007073:Immunoglobulin E