Actions of medroxyprogesterone acetate on the efficacy of cytotoxic drugs: studies with human breast cancer cells in culture.
Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pre-treatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and 100 nM, was independent of its growth-inhibitory action. These findings confirm a previous clinical study and have important implications with regard to the management of advanced breast cancer.
Shaikh
N
N
Breast Clinic, St. Mary's Hospital, London, UK.
Owen
A M
AM
Ghilchik
M W
MW
Braunsberg
H
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D008727:Methotrexate / Q000008:administration & dosage; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D008727:Methotrexate