A T-helper/suppressor ratio in renal allograft recipients after various long-term immunosuppressive regimens.
The response of T-helper and T-suppressor cells to various immunosuppressive regimens was studied in long surviving cadaveric renal allograft recipients. Eight patients were immunosuppressed with Azathioprine and corticosteroids, 12 recipients were treated with a combination of Cyclosporin A, corticosteroids and Azathioprine for 1 year. Both regimens decreased the Th/Ts ratio significantly as compared with healthy controls (p less than 0.05). No correlation between the Th/Ts ratio and the serum creatinine concentration was found. Likewise, the Th/Ts ratio did not correlate with Cyclosporin A blood levels.
Hökl
J
J
Research Institute of Cardiovascular and Transplant Surgery, Brno.
Filkuka
J
J
Neumannová
M
M
Sobotová
D
D
D000328:Adult; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D011863:Radioimmunoassay; D006435:Renal Dialysis; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D003404:Creatinine