[Effect of agents for the chemical prevention of radiation sickness on the cyclic nucleotide content in the bone marrow of mice].
The effect of different chemical compounds on the cAMP/cGMP ratio in the bone marrow of mice and radioresistance of animals has been studied. It has been shown that all compounds possessing radioprotective properties give rise to the cAMP/cGMP ratio in the bone marrow of mice. No changes in cAMP and cGMP level were noted after the administration of nonradioprotective substances. The maximal radioprotective effect coincide in time with the largest increase of the cAMP/cGMP ratio. The injection of radioprotectors at different doses demonstrate clearly that only at radioprotective doses the increase in the cAMP/cGMP ratio takes place. The administration of some substances 2, 15 and 60 min after the irradiation of mice shows that the radioprotective effect, though modest, was evident only in one case of elevated cAMP/cGMP ratio (the injection of 2-Mercaptoethylamine 2 min after the irradiation). Evident radioprotective effect occurs at the cAMP/cGMP ratio of about 170-200%; the ratio of about 130-140% corresponds to small radioprotection.
Pushkareva
N B
NB
Nikol'skiĭ
A V
AV
Koterov
A N
AN
Filippovich
I V
IV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D000242:Cyclic AMP / Q000378:metabolism* / Q000528:radiation effects; D006152:Cyclic GMP / Q000378:metabolism* / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013997:Time Factors
D011837:Radiation-Protective Agents; D000242:Cyclic AMP; D006152:Cyclic GMP
Vliianie sredstv khimicheskoĭ profilaktiki luchevoĭ bolezni na soderzhanie tsiklicheskikh nukleotidov v kostnom mozge mysheĭ.