The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis.
CD4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD4 Leu 8- (CD4 Leu 8+:CD4 Leu 8- ratio = 1:3.5). This is in contrast to autologous peripheral blood where CD4 Leu 8+ cells predominate (CD4 Leu 8+:CD4 Leu 8- ratio = 2.4:1). Functionally CD4 Leu 8- T cells isolated from the colon are able to provide autologous peripheral blood B cell help comparable to that of peripheral blood CD4 Leu 8- T cells. Immunoperoxidase staining of colonic tissue sections confirmed the relative lack of Leu 8 staining cells in the lamina propria and that when present these cells are located in the outer margins of lymphoid follicles.
Ming
R H
RH
University of New Mexico Hospital School of Medicine, Albuquerque 87131.
Strickland
R G
RG
Listrom
M
M
Fenoglio-Preiser
C
C
D000943:Antigens, Differentiation / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D003106:Colon / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D008211:Lymphocyte Cooperation; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D007136:Immunoglobulins