title: Sympathoadrenal responses during bradycardia-hypotension associated with combined infusion of atrial natriuretic factor and prostaglandin E2.
abstract: The adrenergic response to an episode of bradycardia and hypotension associated with atrial natriuretic factor and prostaglandin infusion in a healthy male subject is described. Noradrenaline levels did not change despite a profound fall in blood pressure. In contrast, there was an almost thirty-fold increase in adrenaline levels. This dissociated sympathoadrenal response suggests activation of the Bezold-Jarisch reflex.
authors.affiliation: Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: J
authors.initials: J
authors.lastname: McMurray
authors.forename: A D
authors.initials: AD
authors.lastname: Struthers
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D001919:Bradycardia / Q000150:complications* / Q000503:physiopathology; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
chemical_list: D009320:Atrial Natriuretic Factor; D012083:Renin; D015232:Dinoprostone; D009638:Norepinephrine; D004837:Epinephrine