title: Abnormal thyroid hormone and thyrotropin levels in homozygous sickle cell disease.
abstract: Male patients with SS disease had significantly lower T3 and higher TSH levels than a comparison group. Stimulation with TRH in 10 male sibling pairs showed highly significant increases in T3 and TSH in both patients and sibling controls although the increase in TSH was significantly greater in SS disease. The interpretation of these findings is unclear although the thyroid indices indicate an abnormal pituitary-thyroid axis most consistent with a modest primary thyroid failure.
authors.affiliation: Department of Physiology, University of the West Indies, Kingston, Jamaica, West Indies.
authors.forename: O
authors.initials: O
authors.lastname: Parshad
authors.forename: M C
authors.initials: MC
authors.lastname: Stevens
authors.forename: C
authors.initials: C
authors.lastname: Hudson
authors.forename: J
authors.initials: J
authors.lastname: Rosenthal
authors.forename: G N
authors.initials: GN
authors.lastname: Melville
authors.forename: D T
authors.initials: DT
authors.lastname: Dunn
authors.forename: G R
authors.initials: GR
authors.lastname: Serjeant
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin