Effect of prostaglandin E in multiple experimental models. VI. Effect on T-cell subsets.
Burn injuries have been shown to impair immune function. One of the hypotheses for the etiology of the immunosuppression is that burn injuries result in an elevation of prostaglandin E (PGE) levels which then impair leukocyte function. We evaluated the effect of PGE levels on immune function in multiple animal models utilizing T cell subset levels for our immunologic measurements. Elevations in PGE levels were achieved by administering 16,16-dimethyl-prostaglandin E (dPGE) and reductions by administering indomethacin. The animal models included burned rats, burned-septic rats, and nonburned rats. Neither indomethacin nor dPGE administration resulted in alterations of any of the T cell subset populations in our models.
Waymack
J P
JP
US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234-5012.
Guzman
R F
RF
Burleson
D G
DG
McManus
A T
AT
Mason
A D
AD
Pruitt
B A
BA
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000818:Animals; D002056:Burns / Q000150:complications / Q000276:immunology*; D004195:Disease Models, Animal; D007213:Indomethacin / Q000494:pharmacology; D007958:Leukocyte Count; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000150:complications / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014946:Wound Infection / Q000150:complications / Q000276:immunology*
D011459:Prostaglandins E, Synthetic; D015064:16,16-Dimethylprostaglandin E2; D007213:Indomethacin