title: In vivo 14C isotopic evaluation of amino acid oxidative catabolism in the growing chick. II. Slow respiratory 14CO2 and protein renewal.
abstract: Analysis of the respiratory 14CO2 of growing chicks injected intraperitoneally with [1-14C] or [U-14C]glycine or valine has shown the presence of a delayed 'slow 14CO2' exponential component. The half-lives, about 3 h, are independent of the nature of the amino acid and of the age (1-3 weeks) of the animal. As supported by investigations in cycloheximide-treated chicks of the oxidative catabolism of glycine, valine and acetate, slow 14CO2 is significantly associated with the degradation of short-lived proteins.
authors.affiliation: Institut National des Science et Techniques Nucléaires, CEN Saclay, Gif-sur-Yvette, France.
authors.forename: F
authors.initials: F
authors.lastname: Simonnet
authors.forename: L T
authors.initials: LT
authors.lastname: Ng
authors.forename: P
authors.initials: P
authors.lastname: Auliac
authors.forename: A
authors.initials: A
authors.lastname: Jacob
authors.forename: M
authors.initials: M
authors.lastname: Pascaud
mesh_terms: D000085:Acetates / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide; D002250:Carbon Radioisotopes; D002645:Chickens; D003513:Cycloheximide / Q000494:pharmacology; D005998:Glycine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism*; D012119:Respiration; D014633:Valine / Q000378:metabolism
chemical_list: D000085:Acetates; D000596:Amino Acids; D002250:Carbon Radioisotopes; D011506:Proteins; D002245:Carbon Dioxide; D003513:Cycloheximide; D008715:Methionine; D014633:Valine; D005998:Glycine