[Antispasmodic effect of warm water administered in aerosols or parenteral injections].
The aerosol of thermal water given just before the administration of spasmogenic substances did not prevent the histamine or acetylcholine induced bronchospasm. After a daily parenteral dose of thermal water during 21 days, a systemic delay of the bronchospasm induced by both mediators was observed. With arsenic pretreatment the delay in onset of bronchospasm was shorter.
Magnin
A
A
Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon.
Kantelip
J P
JP
Drutel
P
P
Minh
T T
TT
Magnin
P
P
D000109:Acetylcholine; D000336:Aerosols; D000818:Animals; D001151:Arsenic / Q000008:administration & dosage / Q000494:pharmacology; D001986:Bronchial Spasm / Q000139:chemically induced / Q000628:therapy*; D006632:Histamine; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014867:Water / Q000008:administration & dosage / Q000627:therapeutic use*
D000336:Aerosols; D014867:Water; D006632:Histamine; D001151:Arsenic; D000109:Acetylcholine
Effets antispasmodiques d'une eau thermale administrée en aérosols et en injections parentérales.