title: Immunoreactive atrial natriuretic peptide (ANP) in endoscopic biopsies of the human gastrointestinal tract.
abstract: The human gastrointestinal tract, important for body salt and water balance, was investigated by endoscopic biopsy for the presence of atrial natriuretic peptide (ANP). Using immunohistochemistry, ANP-immunoreactive cells were identified in the lamina epithelialis mucosae of stomach, duodenum, jejunum, colon, and rectum. The findings indicate that ANP plays a role in intestinal salt and water regulation in man. ANP measurements in tissue specimens reached by endoscopic biopsy may be of major interest for future investigations on (patho-)physiological and pharmacological aspects of ANP.
authors.affiliation: Neurologische Universitätsklinik, München, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Ehrenreich
authors.forename: F
authors.initials: F
authors.lastname: Sinowatz
authors.forename: R
authors.initials: R
authors.lastname: Schulz
authors.forename: R M
authors.initials: RM
authors.lastname: Arendt
authors.forename: F D
authors.initials: FD
authors.lastname: Goebel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D001706:Biopsy; D004064:Digestive System / Q000032:analysis* / Q000166:cytology; D004724:Endoscopy; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis*; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D009320:Atrial Natriuretic Factor