Eicosapentaenoic acid alters vascular reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits.
Feeding a diet rich in eicosapentaenoic acid (EPA) to Watanabe heritable hyperlipidemic (WHHL) rabbits resulted in an attenuated aortic contractile response to the vasoconstrictor agent serotonin when compared to responses from WHHL rabbits fed normal rabbit chow. In contrast, only the maximal contractile response to norepinephrine was reduced in EPA-fed rabbit aortas. Additionally, methacholine-induced relaxations were potentiated in aortas obtained from the EPA-fed rabbits. When platelets obtained from EPA-fed rabbits were incubated with arachidonic acid, there was a reduced ability of the platelets to adhere to albumin-coated discs in comparison to control rabbit platelets. These data indicate a potentially beneficial effect of EPA in atherosclerotic WHHL rabbits.
Pfister
S L
SL
University of Texas Southwestern Medical Center, Department of Pharmacology, Dallas 75235-9041.
Rosolowsky
M
M
Schmitz
J M
JM
Clubb
F J
FJ
Campbell
W B
WB
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D004032:Diet; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006949:Hyperlipidemias / Q000097:blood* / Q000235:genetics; D066298:In Vitro Techniques; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits
D001095:Arachidonic Acids; D005227:Fatty Acids; D016718:Arachidonic Acid; D011189:Potassium Chloride; D015118:Eicosapentaenoic Acid