title: [Comparative study of procaterol and salbutamol in single inhaled doses].
abstract: The bronchodilator effect of 0.02 mg of procaterol compared to 0.2 mg of salbutamol as a reference drug administered by single dose inhalation, has been tested in 15 asthmatic patients with a stable clinical situation, using a double-blind study. The clinical value of the administered dose was determined by FEV1, FEV 25-75%, PEF, MEF 50% FVC, SRaw, VC and FRC. These functional tests together with the evaluation of secondary and cardiovascular effects were performed every hour during a 12 hour period. The results revealed that the procaterol aerosol was more potent (although not statistically significant) than the salbutamol, and had a longer activity time. There were no differences in the secondary effects which were mild and transitory. These results suggest that procaterol is a potent bronchodilator, with a long-lasting activity and minimal cardiovascular and adverse side effects.
authors.forename: J A
authors.initials: JA
authors.lastname: Crespo Notario
authors.forename: V
authors.initials: V
authors.lastname: Sobradillo Peña
authors.forename: E
authors.initials: E
authors.lastname: Garnacho López
authors.forename: P M
authors.initials: PM
authors.lastname: Ansola Zubiaurre
authors.forename: J
authors.initials: J
authors.lastname: Mazo Echániz
mesh_terms: D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D017265:Procaterol
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D004983:Ethanolamines; D000420:Albuterol; D017265:Procaterol
vernacular_title: Estudio comparativo del procaterol y salbutamol en inhalación a dosis única.