title: Ocular effects of second generation oral hypoglycemic agents.
abstract: Second generation oral hypoglycemic agents, such as glyburide and glipizide, are often the treatment of choice in non-insulin dependent diabetes mellitus. These sulfonylureas are more potent osmotic agents than their predecessors and may give rise to crystalline lens changes and refractive error shifts in the absence of blood glucose variation. Such a case is presented, as is a detailed description of the mechanism of action of commonly prescribed oral hypoglycemic agents.
authors.affiliation: Department of Ophthalmology, University of California-Davis, Sacramento 95816.
authors.forename: J M
authors.initials: JM
authors.lastname: Lightman
authors.forename: J C
authors.initials: JC
authors.lastname: Townsend
authors.forename: G J
authors.initials: GJ
authors.lastname: Selvin
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy; D005905:Glyburide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects* / Q000473:pathology; D008297:Male; D012030:Refractive Errors / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D005905:Glyburide