[Rhabdomyolysis caused by severe sepsis: discussion on its role in the development of acute renal failure].
Rhabdomyolysis was evaluated by measurement of total creatine kinase (CK) and lactic dehydrogenase (LDH) in 19 patients with severe sepsis; 12 developed acute renal failure (Group B) and 7 did not (Group A). Results were compared to 7 patients with trauma (Group C) and 6 patients with chronic renal failure and minor infections (Group D). CK was higher (p less than 0.005) in Group B than in A. Results in Group C were similar to those in A. Elevation of CK correlated to increases in creatinine (r = 0.655, p less than 0.005). CK levels of Group D patients were lower than those of Group B. Blood pressure, lactate and pO2 were similar in both groups but thrombopenia was noted in Group B patients. Our results suggest that rhabdomyolysis and thrombopenia play a role in the development of renal failure in patients with severe sepsis.
Videla
C
C
Hernández
G
G
Vega
J
J
Borja
H
H
D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009212:Myoglobinuria / Q000150:complications* / Q000201:enzymology; D012206:Rhabdomyolysis / Q000150:complications* / Q000201:enzymology; D018805:Sepsis / Q000150:complications* / Q000201:enzymology
Rabdomiolisis por sepsis grave. Discusión de su rol en el desarrollo de falla renal aguda.