title: Thrombolysis of graft occlusion using high dose urokinase. An alternative to surgical treatment?
abstract: Two cases of acute leg ischemia from unilateral occlusion of an aorto-bifemoral graft, treated with high-dose urokinase intra-arterial infusion, are reported. This therapy allowed identification of the cause of thrombosis, recanalization of the graft and planning of reoperation. Indications for intra-arterial thrombolytic therapy and advantages of urokinase vs streptokinase are discussed.
authors.affiliation: I Istituto di Clinica Chirurgica, Università La Sapienza, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Mingoli
authors.forename: L
authors.initials: L
authors.lastname: Di Marzo
authors.forename: V
authors.initials: V
authors.lastname: Sciacca
authors.forename: M
authors.initials: M
authors.lastname: Castrucci
authors.forename: P
authors.initials: P
authors.lastname: Pavone
authors.forename: C
authors.initials: C
authors.lastname: Farina
authors.forename: A
authors.initials: A
authors.lastname: Tamburelli
authors.forename: A
authors.initials: A
authors.lastname: Cavallaro
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D000800:Angioplasty, Balloon; D001012:Aorta, Abdominal / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012086:Reoperation; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator