title: [Effect of mytilan, a polysaccharide from Crenomytilus grayanus, on the functional activity of peritoneal macrophages].
abstract: The studies showed that mytilan, a polysaccharide from Crenomytilus grayanus had a marked activating effect on macrophages evident from respective morphological changes and increased metabolic and functional activity of the macrophages. Exposure to mytilan resulted in an increase in the number of the macrophages and their size (optic microscopy), changes in their surface (scanning microscopy) and ultrastructural reconstruction of the cells (light microscopy). It was shown that subcutaneous and intraperitoneal administration of mytilan defined a decrease in the activity of 5'-nucleotidase in the macrophages of the peritoneal exudate from ++noninbred mice and mice CBA. Moreover, under the influence of mytilan the macrophage phagocytic activity against E. coli, S. aureus, P. aeruginosa and P. vulgaris increased in vivo and in vitro.
authors.forename: N V
authors.initials: NV
authors.lastname: Krylova
authors.forename: V G
authors.initials: VG
authors.lastname: Zhukov
authors.forename: R G
authors.initials: RG
authors.lastname: Ovodova
authors.forename: M A
authors.initials: MA
authors.lastname: Tumanian
authors.forename: G B
authors.initials: GB
authors.lastname: Kirillicheva
mesh_terms: D015720:5'-Nucleotidase; D000818:Animals; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008974:Mollusca; D009708:Nucleotidases / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D011134:Polysaccharides; C030207:mytilan; D009708:Nucleotidases; D015720:5'-Nucleotidase
vernacular_title: Vliianie mitilana--polisakharida iz midii Crenomytilus grayanus--na funktsional'nuiu aktivnost' peritoneal'nykh makrofagov.