Warthin's tumor with malignant lymphoma. DNA analysis of paraffin-embedded tissue.
The authors report a case of malignant lymphoma, small lymphocytic type, involving the lymphoid stroma of a Warthin's tumor of the parotid gland. This was confirmed by the presence of a monoclonal immunoglobulin heavy chain gene rearrangement, demonstrated by Southern blot hybridization of DNA extracted from paraffin-embedded tissue. Similar techniques showed only germline immunoglobulin gene bands in two control cases of Warthin's tumor.
Bunker
M L
ML
Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania.
Locker
J
J
D000235:Adenolymphoma / Q000235:genetics / Q000473:pathology*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D015321:Gene Rearrangement; D006652:Histological Techniques; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009693:Nucleic Acid Hybridization; D010307:Parotid Neoplasms / Q000235:genetics / Q000473:pathology*
D004247:DNA; D004262:DNA Restriction Enzymes