title: Factors influencing pertechnetate uptake by rabbit knees.
abstract: The accumulation of radioactivity over rabbit knees immediately after the injection of 99mTc-pertechnetate or one of two 99mTc-labelled particulate preparations has been measured in animals with and without experimental arthritis. The results indicate that in inflamed, but not normal joints, a peak of radioactivity is detectable within 9 seconds of injection and suggest that the rate of accumulation of radioactivity over the joint may be a more sensitive indicator of inflammatory activity than measurement at a fixed time. Clearance from the circulation and tissue distribution of the three radioactive preparations were also measured.
authors.affiliation: Strangeways Research Laboratory, Cambridge.
authors.forename: D R
authors.initials: DR
authors.lastname: Bard
authors.forename: D P
authors.initials: DP
authors.lastname: Page-Thomas
mesh_terms: D000818:Animals; D001168:Arthritis / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007719:Knee Joint / Q000378:metabolism*; D008863:Microspheres; D011817:Rabbits; D012016:Reference Values; D013670:Sodium Pertechnetate Tc 99m / Q000097:blood / Q000493:pharmacokinetics*; D013667:Technetium / Q000097:blood; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m