Cytoplasmic islet cell antibodies in children with type I diabetes.
In a group of 72 type I juvenile diabetics we investigated the prevalence of islet cell antibodies (ICA). Their occurrence rate was followed up over 1-3 years. In 66 patients also neutralizing antibodies and IgM antibodies to Coxsackie B viruses were determined. ICA positivity was recorded in 21 out of 38 Coxsackie positive diabetics (55%), compared to 13 out of 28 Coxsackie negative diabetics (46%). ICA were found in a total of 73% of diabetic patients. The postinitial course of diabetes, assessed according to partial remissions, did not differ substantially between ICA positive and ICA negative patients. ICA persisted over a longer period of time in children who had suffered from Coxsackie B virus infection than in children who had not experienced this virus infection (p less than 0.05). The concurrent action of Coxsackie B virus infection before the manifestation of diabetes may contribute to the heterogeneity of autoimmune processes in some juvenile diabetics.
Michalková
D
D
Kostál
M
M
Rajcáni
J
J
Petrovicová
A
A
Bircák
J
J
Kolár
J
J
Barák
L
L
Hrabcáková
D
D
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male
D000914:Antibodies, Viral; D001323:Autoantibodies; C024211:islet cell antibody