Bone disorder in cardiomyopathic hamsters.
Bones of cardiomyopathic hamsters (UM-X7.1 Syrian hamsters), at 5, 10 and 20 weeks of age, were compared chemically and histomorphologically with those of normal Syrian hamsters. Femurs of UM-X7.1 hamsters were significantly shorter than those of normal hamsters, and the mean dry weight, mean volume, mean ash weight per unit bone volume and mean ash as a percentage of dry weight of femurs were all significantly less in UM-X7.1 hamsters. The bone disorder preceded the myocardial calcium precipitation and myocardial hypertrophy in the cardiomyopathic hamsters. In addition, the percentage of cortical area measured on the cross-section of tibia and the appositional rate of bone minerals, determined by a tetracycline labelling technique, were also lower in the UM-X7.1 hamsters. These findings suggest that the bone disorder was associated with decreased bone formation in the UM-X7.1 Syrian hamsters.
Togari
A
A
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Arai
M
M
Matsumoto
S
S
Tarumoto
Y
Y
Takahashi
H
H
D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D006332:Cardiomegaly; D009202:Cardiomyopathies / Q000378:metabolism / Q000473:pathology*; D006224:Cricetinae; D005260:Female; D005269:Femur / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*; D008647:Mesocricetus; D009206:Myocardium / Q000032:analysis / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000032:analysis / Q000000981:diagnostic imaging / Q000473:pathology*
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002118:Calcium