Diagnosis of T-cell lymphoma using beta F1, anti-T-cell receptor beta chain antibody.
The reactivity of a new monoclonal antibody to the T-cell beta chain antigen receptor (beta F1) with routinely processed paraffin sections from patients with T-cell lymphoma is described. Staining of tumour cells was seen in 36/47 cases of T-cell lymphoma. No staining was seen in any cases of B-cell lymphoma (0/21 cases), nine of which had previously been shown to react with other T-cell antibodies (MT1/UCHL1). We conclude that beta F1 is a specific marker for demonstrating a T-cell histogenesis of lymphoma and with advantages over other currently available antibodies reactive with paraffin sections.
Krajewski
A S
AS
Department of Pathology, University Medical School, Edinburgh, UK.
Myskow
M W
MW
Salter
D M
DM
Cunningham
D S
DS
Ramage
E F
EF
D000911:Antibodies, Monoclonal / Q000032:analysis; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013601:T-Lymphocytes / Q000473:pathology*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta