Tumour-associated proliferative responses in vitro of regional lymph nodes draining solid cancers in man.
The proliferative responses in vitro of tumour-draining lymph node lymphocytes were evaluated against autologous colon and lung carcinoma cells. The reactivity of lymphocytes appeared to be directed against tumour-associated rather than tumour-specific antigens. The lymphocyte reactivity detected was not due to an autologous mixed lymphocyte reaction. Recombinant interleukin-2 augmented the responses detected but not their tumour specificity. Phenotypic characterisation indicated the presence of T suppressor/cytotoxic (TS/C) cells as well as natural killer (NK) cells. Only the later, however, were active in functional cytotoxicity assays. The inability to generate both tumour-specific proliferation of tumour-draining lymph node lymphocytes and tumour-specific cytotoxic killer cells may be due to the presence of suppressor cells in the regional lymph nodes; preliminary data suggest the presence of such cells.
Mainou-Fowler
T
T
Department of Surgery, University of Aberdeen, Scotland, UK.
Eremin
O
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002470:Cell Survival; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008875:Middle Aged; D010641:Phenotype; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D007376:Interleukin-2; D011994:Recombinant Proteins; D006854:Hydrocortisone