title: In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.
abstract: 3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for colony formation of erythroid and granulocytic cells.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Tsushita
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Hotta
authors.forename: M
authors.initials: M
authors.lastname: Saneyoshi
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Tomoda
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000633:toxicity*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D003114:Colony-Forming Units Assay; D015224:Dideoxynucleosides / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology / Q000633:toxicity*; D016047:Zalcitabine; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; D009705:Nucleosides; D015215:Zidovudine; D016047:Zalcitabine