[Relation of atrial natriuretic peptide and endogenous digoxin-like activity in the plasma of young hypertensive patients].
The relationships between plasma digoxin-like immunoreactivity (DLS) and atrial natriuretic peptide (ANP) were investigated in 10 young essential hypertensives (mean age 22 +/- 2 years) and in 10 normotensives. In young hypertensives, plasma DLS and ANP were at an average level of 31.2 +/- 8 pg/ml and 56.7 +/- 20 pg/ml respectively, showing a significant correlation (r = 0.66; p less than 0.05). In normal subjects plasma DLS and ANP were at an average level of 19.1 +/- 8 pg/ml and 37.6 +/- 16.7 pg/ml respectively (n.s.). Plasma DLS and ANP were higher in hypertensives than in normotensives (p less than 0.01). In conclusion, DLS and ANP appear to have a similar behaviour, possibly due to their modulation by common stimuli.
Musca
A
A
Ferri
C
C
Cammarella
S
S
Tani
S
S
Valentino
S
S
Santucci
A
A
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D002298:Cardenolides; D004077:Digoxin; D006801:Humans; D006973:Hypertension / Q000097:blood*; D012503:Saponins
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D009320:Atrial Natriuretic Factor
Rapporti tra peptide atriale natriuretico e attività digossinosimile endogena nel plasma di pazienti giovani ipertesi.