The role of obesity, hypertension and diet in diabetes and its complications in the Spontaneous Hypertensive/NIH-corpulent rat.
The Spontaneous Hypertensive/NIH-corpulent rat is a recently developed genetic model of obesity and diabetes. The strain exhibits both metabolic and histopathological characteristics associated with non-insulin dependent diabetes mellitus in humans. This rodent model is unique in that glucose intolerance is expressed in both sexes and in both phenotypes.
Michaelis
O E
OE
Beltsville Human Nutrition Research Center, Agriculture Research Service, Maryland.
Carswell
N
N
Velasquez
M T
MT
Hansen
C T
CT
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000209:etiology* / Q000378:metabolism; D004032:Diet / Q000009:adverse effects; D005260:Female; D005838:Genotype; D006973:Hypertension / Q000150:complications*; D008297:Male; D009765:Obesity / Q000150:complications* / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR
D001786:Blood Glucose