title: Effect of exercise, hyperpnea, and bronchoconstriction on plasma atrial natriuretic peptide.
abstract: To examine whether endogenous secretion of atrial natriuretic peptide (ANP) modifies the bronchomotor response to moderately strenuous exercise and, conversely, whether hyperpnea of exercise or bronchoconstriction alone modulates the release of ANP, we compared the rise in specific airway resistance and the rise in circulating immunoreactive ANP (IR-ANP) induced by a 5-min submaximal exercise and by eucapnic hyperpnea with cold dry air and exercise-matched minute ventilation in six healthy individuals and in five subjects with clinically stable asthma. As expected, the increase in specific airway resistance from base line provoked by exercise was greater in the asthmatic subjects (from 11.8 +/- 7.1 to 34.0 +/- 18.6 l.cmH2O.l-1.s-1) than in the healthy subjects (from 3.7 +/- 1.2 to 4.5 +/- 1.9 l.cmH2O.l-1.s-1). In both groups, exercise was associated with a similar and significant rise in plasma IR-ANP levels, ranging from 222 to 550% from base-line value in the healthy group and from 176 to 1,120% from base-line value in the asthmatic group. Peak plasma IR-ANP levels occurred from 3 to 15 min after completion of exercise with a return to base-line values within 60 min. Although eucapnic hyperpnea was associated with a similar increase in specific airway resistance as was exercise, it provoked an increase in circulating IR-ANP in only one subject.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco 94143-0130.
authors.forename: I
authors.initials: I
authors.lastname: Rubinstein
authors.forename: T F
authors.initials: TF
authors.lastname: Reiss
authors.forename: D G
authors.initials: DG
authors.lastname: Gardner
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: B G
authors.initials: BG
authors.lastname: Bigby
authors.forename: H A
authors.initials: HA
authors.lastname: Boushey
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000502:physiology; D001249:Asthma / Q000097:blood / Q000503:physiopathology*; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012119:Respiration / Q000502:physiology*
chemical_list: D009320:Atrial Natriuretic Factor