The effect of acute ACE inhibition on atrial natriuretic peptide.
1. The effect of acute angiotensin converting enzyme (ACE) inhibition on the plasma concentrations of atrial natriuretic peptide (ANP) was investigated in a single-blind placebo controlled crossover study in healthy volunteers. 2. Intravenous infusion of 2 mg cilazaprilat resulted in a significant and short lasting inhibition of ACE as evidenced by a decrease of plasma angiotensin II and an increase in plasma renin activity. 3. When compared with placebo cilazaprilat lowered diastolic pressure and increased heart rate significantly. 4. No effect of cilazaprilat was found on plasma ANP levels, suggesting that angiotensin II does not mediate ANP release.
Doorenbos
C J
CJ
Department of Nephrology, University Hospital, Leiden, The Netherlands.
van Brummelen
P
P
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D017315:Cilazapril / Q000031:analogs & derivatives*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011724:Pyridazines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D012964:Sodium / Q000652:urine
D000806:Angiotensin-Converting Enzyme Inhibitors; D011724:Pyridazines; D000804:Angiotensin II; D017315:Cilazapril; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin; C045980:cilazaprilat