Effect of preclotting on the porosity and thrombogenicity of knitted Dacron grafts.
The effects of single- and four-stage preclotting methods on graft porosity and thrombogenicity were compared in two types of Dacron prosthesis. The single-stage method significantly reduced leakage of blood (P less than 0.001), but did not seal the grafts. The four-stage method rendered the grafts impermeable at the second step. Thrombogenicity was compared by perfusing preclotted grafts with fresh heparinized blood (containing 111In-labelled platelets) in an artificial circulation. Platelet deposition and consumption were significantly less in the four-stage method whilst platelet function remained unchanged during perfusion. We conclude that the four-stage technique is superior to standard preclotting methods by rendering knitted Dacron grafts impermeable and hypothrombogenic.
Sheehan
S J
SJ
Cardiac Research Unit, Killingbeck Hospital, Leeds, UK.
Rajah
S M
SM
Kester
R C
RC
D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates; D013927:Thrombosis / Q000517:prevention & control; D013997:Time Factors; D014654:Vascular Patency; D014914:Whole Blood Coagulation Time
D011093:Polyethylene Terephthalates