title: [How should the plasma ACTH level in treated Addison's disease patients be interpreted?].
abstract: The ACTH plasma levels of 73 treated Addisonian patients have been analysed and compared to those obtained in 40 normal subjects after metyrapone-induced nocturnal cortisol deprivation (75 to 700 pg/ml). Using this new criterion, it appears that patients with ACTH plasma levels lower than 75 pg/ml are most often over-treated; those with ACTH plasma levels between 75 to 700 pg/ml are most often well substituted; and those with ACTH plasma levels higher than 700 pg/ml are under-treated. In this latter group coincidental high plasma renin activity is generally present, pointing to the possible role of the renin-angiotensin system in maintaining high ACTH plasma levels.
authors.affiliation: Centre de Recherches des Maladies Endocriniennes et Métaboliques, Hôpital Cochin, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Pehuet-Figoni
authors.forename: X
authors.initials: X
authors.lastname: Bertagna
authors.forename: F
authors.initials: F
authors.lastname: Girard
authors.forename: H
authors.initials: H
authors.lastname: Bricaire
authors.forename: J P
authors.initials: JP
authors.lastname: Luton
mesh_terms: D000224:Addison Disease / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D008797:Metyrapone; D008875:Middle Aged
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D008797:Metyrapone
vernacular_title: Comment interpréter l'ACTH plasmatique de l'addisonien traité?