title: High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.
abstract: Symptomatic brain metastases are found in about 40% of patients with small cell lung cancer. Cranial irradiation is the first line treatment for this form of metastatic disease. Frequently brain metastases recur after this treatment or develop after prophylactic cranial irradiation. For these patients no effective antitumour therapy is available. In this study the efficacy of high dose etoposide 1.5 g m-2 was evaluated. In 10 (43%) out of 23 evaluable patients a response was seen. Toxicity was severe with five aplasia-related deaths. For palliative purposes this regimen is too toxic in heavily pretreated patients.
authors.affiliation: Department of Pulmonary Diseases, State University Hospital, Groningen, The Netherlands.
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
authors.forename: H
authors.initials: H
authors.lastname: Haaxma-Reiche
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
authors.forename: A
authors.initials: A
authors.lastname: Kirkpatrick
authors.forename: J G
authors.initials: JG
authors.lastname: McVie
authors.forename: J P
authors.initials: JP
authors.lastname: Kleisbauer
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000556:secondary*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D005047:Etoposide