[Antiherpetic activity of Soviet-made phosphonic acid derivatives and their combinations with interferon inducers in a model of ophthalmic herpes].
A comparative analysis of the effectiveness of national phosphonic acid derivatives (FUK and FMK) and acyclic nucleoside, acycloguanosine (Acg), as well as interferon (INF) inducers, lafarin and ridostin, was carried out on the model of herpetic conjunctivitis in rabbits and guinea pigs. Upon therapeutic-prophylactic administration, lafarin reduced the intensity of eye symptoms 2-fold as compared with the controls (infected but untreated guinea-pigs). In rabbits with herpetic conjunctivitis, the therapeutic schedule of the use of FMK (FUK) and Acg shortened the duration of the disease by 7 and 11 days, respectively, as compared with the control. The combined use of chemical drugs and INF inducers, lafarin or ridostin, reduced the intensity of the disease manifestations 3-fold and shortened the duration of the disease by 8-11 days. The survival rate was 80%-100%. Use of the combination of the two chemical drugs gave an additive effect. The synergistic effect was observed with FMK used in combination with lafarin.
L'vov
N D
ND
Samoĭlovich
E O
EO
Tikhonchuk
I A
IA
Chepaĭkina
T A
TA
Tsvetkov
E N
EN
D000818:Animals; D002506:Cephalexin / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet; D006168:Guinea Pigs; D007369:Interferon Inducers / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D012331:RNA, Fungal / Q000627:therapeutic use; D011817:Rabbits
D007369:Interferon Inducers; D009943:Organophosphorus Compounds; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D002506:Cephalexin
Protivogerpeticheskaia aktivnost' otechestvennykh proizvodnykh fosfonovoĭ kisloty i ikh sochetaniĭ s induktorami interferona na modeli oftal'mogerpesa.