title: Synthesis of 18F-labelled VP 16-213 and podophyllotoxin using acetyl hypofluorite.
abstract: The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using [18F]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational changes.
authors.affiliation: Radio-Nuclide-Centre (RNC), Free University, Amsterdam, The Netherlands.
authors.forename: G W
authors.initials: GW
authors.lastname: Visser
authors.forename: A T
authors.initials: AT
authors.lastname: Bijma
authors.forename: J A
authors.initials: JA
authors.lastname: Dijksman
authors.forename: J D
authors.initials: JD
authors.lastname: Herscheid
mesh_terms: D000085:Acetates; D004952:Esters; D005047:Etoposide / Q000031:analogs & derivatives*; D005461:Fluorine; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D008968:Molecular Conformation; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
chemical_list: D000085:Acetates; D004952:Esters; D005462:Fluorine Radioisotopes; D005461:Fluorine; D005047:Etoposide; C040801:acetyl hypofluorite; D011034:Podophyllotoxin