title: Cardiac allograft prolongation in mice treated with combined posttransplantation total-lymphoid irradiation and anti-L3T4 antibody therapy.
abstract: Neonatal cardiac allograft survival was examined in mice treated with anti-L3T4 antibody, posttransplantation total lymphoid irradiation (TLI) or a combination of both therapies. Independently, both posttransplantation TLI and short-course antibody treatment allowed minimal prolongation. However, synergistic prolongation in graft survival was observed with the combination (synergistic) therapy. Fluorescence-activated cell sorter analysis of peripheral blood lymphocytes from animals treated with combined anti-L3T4 and posttransplantation TLI additionally revealed "synergy" with respect to the degree of peripheral lymphocyte depletion.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, California 94305.
authors.forename: D K
authors.initials: DK
authors.lastname: Trager
authors.forename: B A
authors.initials: BA
authors.lastname: Banks
authors.forename: G E
authors.initials: GE
authors.lastname: Rosenbaum
authors.forename: B I
authors.initials: BI
authors.lastname: Holm
authors.forename: J A
authors.initials: JA
authors.lastname: Shizuru
authors.forename: S
authors.initials: S
authors.lastname: Strober
authors.forename: C G
authors.initials: CG
authors.lastname: Fathman
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology; D003131:Combined Modality Therapy; D006085:Graft Survival; D016027:Heart Transplantation; D007165:Immunosuppression Therapy / Q000379:methods*; D008208:Lymphatic System / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly