Protection against salicylate ototoxicity by zinc.
One day after oral application of 700 mg (5.5 mmol)/kg salicylic acid given as Na salicylate, hearing thresholds in rats, measured by acoustically evoked responses at 10 and 20 kHz, were increased. Salicylate-induced hearing loss was completely prevented by simultaneous s.c. injection of 6 mg (92 mumol)/kg Zn, whereas simultaneous s.c. injection of 1.5 mmol/kg MgCl2 had no effect. Simultaneous s.c. injection of 100 mg (152 mumol)/kg desferrioxamine had only a minor beneficial effect indicating that salicylate-induced Fe accumulation plays no significant role in salicylate ototoxicity.
Günther
T
T
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, FRG.
Rebentisch
E
E
Vormann
J
J
D000818:Animals; D003676:Deferoxamine / Q000627:therapeutic use; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000517:prevention & control*; D007279:Injections, Subcutaneous; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015032:Zinc / Q000627:therapeutic use*
D008274:Magnesium; D003676:Deferoxamine; D015032:Zinc; D012980:Sodium Salicylate