Systemic and regional haemodynamic responses to microinjection of 5-HT agonists in the rostral ventrolateral medulla in the rat.
In anaesthetised rats bilateral microinjection of 2 nmol 5-HT or the agonists 5-carboxyamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) into nucleus paragigantocellularis lateralis produced a fall in blood pressure and heart rate, an increase in hindlimb vascular conductance but no significant change in renal conductance. In contrast, alpha-methyl-5-HT injected into the same region had no such effects. It is suggested that these cardiovascular effects are mediated by activation of 5-HT1A receptors. The possibility that there may be differences between species with respect to central 5-HT receptor-mediated cardiovascular effects is also discussed.
Lovick
T A
TA
Department of Physiology, Medical School, Birmingham, U.K.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C047087:5-carboxamidotryptamine