"Body burden" of phosphonoformic acid after topical and vaginal administration to rabbits and beagle dogs.
Trisodium phosphonoformate (PFA), an antiviral compound, was studied in two animal species, dogs and rabbits, for systemic absorption after vaginal and topical application. Antiviral agents to be possibly used against genital and skin herpes should penetrate deeply into the skin and, hopefully, should remain there as long as possible with no or little systemic uptake. In the rabbit the absolute bioavailability after vaginal and topical administration is 14% and 12%, respectively, and in the dog 34% and 3%, respectively. Because PFA has a low toxicity the body burden may be acceptable if the compound is found to be high clinical benefit.
Hussain
A S
AS
College of Pharmacy, Ohio Northern University, Ada 45810.
Ritschel
W A
WA
D000282:Administration, Intravaginal; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D001682:Biological Availability; D001822:Body Burden; D004285:Dogs; D005260:Female; D017245:Foscarnet; D007275:Injections, Intravenous; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism* / Q000493:pharmacokinetics; D011817:Rabbits
D000998:Antiviral Agents; D009943:Organophosphorus Compounds; D017245:Foscarnet; D010746:Phosphonoacetic Acid