title: [Modeling of the "universal" bone marrow using monoclonal antibodies].
abstract: The data on the application of monoclonal antibodies (ICO-10) and rabbit complement for working the conditions of allogeneic bone marrow transplantation are presented in the paper. The treatment with monoclonal antibodies and bone marrow complement from BALB/c mice for 2 times prevented the development of transplant versus host reaction and completely protected lethally irradiated (CBA X X C57B1/6)FI mice-recipients from death. Thymus atrophy and the absence of T-cells in the peripheral blood was observed in these mice. The erythrocytes had markers characteristic of BALB/c and (CBA X C57B1/6)FI mice. Mouse splenocytes did not respond to the cells of donors and recipients in mixed lymphocyte culture reaction.
authors.forename: K L
authors.initials: KL
authors.lastname: Chimishkian
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Baryshnikov
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Ovumian
authors.forename: V N
authors.initials: VN
authors.lastname: Kostrykina
authors.forename: I A
authors.initials: IA
authors.lastname: Karpov
authors.forename: A M
authors.initials: AM
authors.lastname: Buntsevich
authors.forename: E G
authors.initials: EG
authors.lastname: Slavina
authors.forename: G A
authors.initials: GA
authors.lastname: Udalov
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kadagidze
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003165:Complement System Proteins / Q000627:therapeutic use; D006087:Graft vs Host Reaction; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D003165:Complement System Proteins
vernacular_title: Modelirovanie "universal'nogo" kostnogo mozga s pomoshch'iu monoklonal'nykh antitel.