title: The potency testing of pseudorabies vaccines in pigs. A proposal for a quantitative criterion and a minimum requirement.
abstract: A criterion for the potency testing of pseudorabies vaccine based on the difference between the mean weight gain during the seven days after pathogenic challenge of vaccinated or control piglets is proposed. This criterion, termed delta G7, has been studied as a function of initial weight variation of the animals, different challenge strains and the period between challenge and the end of the test. The statistical analysis of results optimizes the experimental parameters and gives rise to a quantitative test which discriminates between vaccinates and controls and substantiates a proposal for a minimum vaccine potency requirement. The implementation of the method proposed is compatible with current practice in control laboratories.
authors.affiliation: Rhône Merieux, IFFA Laboratory, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Stellmann
authors.forename: P
authors.initials: P
authors.lastname: Vannier
authors.forename: G
authors.initials: G
authors.lastname: Chappuis
authors.forename: A
authors.initials: A
authors.lastname: Brun
authors.forename: M
authors.initials: M
authors.lastname: Dauvergne
authors.forename: D
authors.initials: D
authors.lastname: Fargeaud
authors.forename: M
authors.initials: M
authors.lastname: Bugand
authors.forename: X
authors.initials: X
authors.lastname: Colson
mesh_terms: D000818:Animals; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007700:Kinetics; D011557:Pseudorabies / Q000517:prevention & control; D013552:Swine; D015164:Vaccines, Inactivated / Q000494:pharmacology / Q000592:standards; D014765:Viral Vaccines / Q000494:pharmacology / Q000592:standards*; D015430:Weight Gain
chemical_list: D015164:Vaccines, Inactivated; D014765:Viral Vaccines