title: The effect of initial operative repair on the recovery of intestinal function in gastroschisis.
abstract: Recent reports concerning the treatment of gastroschisis suggest that primary closure results in more rapid return of gastrointestinal function, a shortened hospitalization, diminished perinatal complications, and improved long-term survival. A 4-year retrospective review of infants treated for gastroschisis at the University of Florida yielded 30 infants requiring repair of this abdominal wall defect. The series included 19 males and 11 females, and the average abdominal wall defect measured 4 cm in its greatest dimension. Nine infants (mean weight, 2,275 gm) were repaired using a staged closure using a silastic (six) or cutaneous (three) silo. Complete fascial closure was accomplished in an average of 8 days in the silastic group and 15 days in the infants with skin flaps. Mean age at start of enteral feeds was 23 days, with complete oral feedings at 43 days. Twenty-one infants (mean weight, 2,127 gm) underwent primary fascial closure. Three deaths occurred in the perioperative period: one from acute renal failure and two from sepsis secondary to a segment of necrotic intestine. An additional infant developed postoperative necrotizing entercolitis but recovered. Two infants in this group also had jejuno-ileal atresia requiring extensive small bowel resection. In the remaining 15 infants, oral alimentation was initiated for an average of 23 days, with full oral alimentation at 46 days. The data suggest that the recovery of the gastrointestinal system, adequate enough to support total oral alimentation, is unrelated to the initial surgical procedure chosen to obtain fascial closure in the newborn with gastroschisis. In addition, vigorous attempts at primary fascial closure may jeopardize intestinal viability, diminish ventilatory function, and result in unnecessary morbidity and mortality.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, University Hospital of Jacksonville.
authors.forename: M S
authors.initials: MS
authors.lastname: Bryant
authors.forename: J J
authors.initials: JJ
authors.lastname: Tepas
authors.forename: D L
authors.initials: DL
authors.lastname: Mollitt
authors.forename: J L
authors.initials: JL
authors.lastname: Talbert
authors.forename: D L
authors.initials: DL
authors.lastname: String
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D004068:Digestive System Physiological Phenomena; D013505:Digestive System Surgical Procedures; D000071938:Fasciotomy; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food; D008297:Male; D010288:Parenteral Nutrition; D012826:Silicone Elastomers; D013524:Surgical Flaps; D013997:Time Factors
chemical_list: D012826:Silicone Elastomers