Adenovirus persistence in man. Defective E1A gene product targeting of infected cells for elimination by natural killer cells.
Human adenovirus types 2 and 5 (Ad2/5) cause persistent infections in man. Ad2/5 infection of rodent cells induces increased susceptibility to NK lymphocyte-mediated lysis that is dependent on target cell expression of Ad2/5 E1A gene products. In contrast to infected rodent cells, Ad2/5 infection of human fibroblasts and epithelial cells does not result in increased susceptibility to either human or rodent NK cell-mediated killing, despite high levels of E1A protein expression. This functional inactivity of E1A gene products in Ad-infected human cells may contribute to adenoviral persistence by rendering the NK cell response to Ad-infected cells ineffective.
Routes
J M
JM
Robert W. Lisle Research Laboratory, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Cook
J L
JL
D000257:Adenoviridae Infections / Q000276:immunology*; D017456:Adenovirus Early Proteins; D000258:Adenovirus Infections, Human / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008647:Mesocricetus; D008970:Molecular Weight; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D013045:Species Specificity
D017456:Adenovirus Early Proteins; D009856:Oncogene Proteins, Viral