title: [Effectiveness and tolerance of a new molecule with secreto-dynamic activity: nesosteine].
abstract: 232 patients with acute or chronic respiratory disorders characterized by increased secretion, were included in an open multicentre trial to evaluate the tolerability and the activity of a new molecule with secreto-dynamic action, nesosteine. The drug was administered orally at the dose of 900 mg/day for two consecutive weeks. The incidence of side effects (11.6%) was comparable to that observed in studies carried out on molecules with similar activity. Undesirable reactions were found mainly at the gastrointestinal level. Side effects were slight/moderate in most cases; only 3 patients abandoned treatment. Nesosteine therapeutic activity was highly valid; cough and expectorate were favourably affected by treatment. The drug, by restoring the natural characteristics of excreate viscoelasticity, favored a better mucociliary clearance and a more incisive cough expelling action. The activity/tolerability ratio was judged excellent/good by the investigator in 83% of the patients treated.
authors.forename: P G
authors.initials: PG
authors.lastname: Gatto
authors.forename: C
authors.initials: C
authors.lastname: Gramolini
authors.forename: S
authors.initials: S
authors.lastname: Valenti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005100:Expectorants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D005100:Expectorants; D013844:Thiazoles; C049549:nesosteine
vernacular_title: Efficacia e tollerabilità di una nuova molecola ad attività secretodinamica: la nesosteina.