title: T lymphocyte subsets, natural killer cell cytotoxicity and autologous mixed lymphocyte response in children after splenectomy because of hereditary spherocytosis.
abstract: Lymphocyte subpopulations and autologous mixed lymphocyte reaction (AMLR) studied in 13 hereditary sphereocytosis and 21 postsplenectomy patients; the operation was performed because of hereditary spherocytosis. Significant increases of Th cells and the Th/Ts ratio have been noted in children with hereditary spherocytosis. Splenectomy because of spherocytosis has resulted in an increase in Ts cell number and diminution of Th/Ts ratio. Hereditary spherocytosis patients showed both diminished natural killer cell activity and AMLR proliferation. Splenectomy normalized the above parameters. The presented data demonstrated disturbances in T lymphocyte number and functions both before and after splenectomy in children with hereditary spherocytosis.
authors.affiliation: Department of Pathophysiology, Pediatrics Surgery Medical School AM, Lódź, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Tchórzewski
authors.forename: K
authors.initials: K
authors.lastname: Zeman
authors.forename: Z
authors.initials: Z
authors.lastname: Baj
authors.forename: A
authors.initials: A
authors.lastname: Płuzańska
authors.forename: A
authors.initials: A
authors.lastname: Chilarski
authors.forename: E
authors.initials: E
authors.lastname: Majewska
authors.forename: L
authors.initials: L
authors.lastname: Pokoca
authors.forename: I
authors.initials: I
authors.lastname: Bugała
authors.forename: J
authors.initials: J
authors.lastname: Kantorski
mesh_terms: D002648:Child; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D013103:Spherocytosis, Hereditary / Q000097:blood / Q000276:immunology* / Q000601:surgery; D013156:Splenectomy; D013601:T-Lymphocytes / Q000276:immunology