title: The paradigm of Huntington disease.
abstract: I recall it as vividly as though it had occurred but yesterday. It made a most enduring impression upon my boyish mind which was my very first impulse to choosing chorea as my virgin contribution to medical lore. Driving with my father through a wooded road leading from East Hampton to Amagansett we suddenly came upon two women, mother and daughter, both tall and thin, almost cadaverous, both bowing, twisting, grimacing. I stared in wonderment, almost in fear. What could it mean? My father paused to speak with them and we passed on. Then my Gamaliel-like instruction began; my medical education had its inception. From this point on, my interest in the disease has never wholly ceased. [George Huntington, at 59, recalling how at the age of 8 years he first saw Huntington disease while traveling with his physician father on his professional rounds in 1858].
authors.affiliation: Department of Biology, Swarthmore College, PA 19081.
authors.forename: J B
authors.initials: JB
authors.lastname: Jenkins
authors.forename: P M
authors.initials: PM
authors.lastname: Conneally
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004501:Education, Medical; D004992:Ethics, Medical; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D006816:Huntington Disease / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014743:Videotape Recording