title: Surgical resection in the treatment of stages I-II of small cell lung carcinoma (SCLC).
abstract: From 1981 to 1986, 17 patients with resected small cell lung carcinoma (SCLC) staged as I or II according to the new TNM classification were recruited for a prospective study to evaluate the effectiveness of surgery and postoperative chemotherapy (plus locoregional radiotherapy only when a nonradical resection was accomplished) in the treatment of early stages of the disease. Six patients received full protocol chemotherapy (6 courses) and 8 a mean of 79.1% of the planned courses. Three patients received non adjuvant treatment. Locoregional radiotherapy for residual disease was administered in 2 cases. One patient died for myelosuppression due to chemotherapy and 10 for recurrences of cancer, all within the 20th postoperative month. Metastases accounted 80% of overall recurrences. Six patients were alive and tumor-free at 18, 22, 39, 44, 47 and 51 months from resection. Actuarial observed 3-year survival was 32%.
authors.affiliation: Divisione di Oncologia Chirurgica Toracica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Cataldo
authors.forename: A V
authors.initials: AV
authors.lastname: Bedini
authors.forename: G
authors.initials: G
authors.lastname: Muscolino
authors.forename: M
authors.initials: M
authors.lastname: Valente
authors.forename: U
authors.initials: U
authors.lastname: Pastorino
authors.forename: P
authors.initials: P
authors.lastname: Bidoli
authors.forename: S
authors.initials: S
authors.lastname: Pilotti
authors.forename: G
authors.initials: G
authors.lastname: Ravasi
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging