Neuronal antinuclear antibodies in a patient with Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma.
A patient with small-cell lung carcinoma and the Lambert-Eaton myasthenic syndrome had circulating neuronal antinuclear antibodies. Serum stained the nuclei of all neurons in sections of human brain and identified a closely spaced group of 33-39 kDa proteins in immunoblots of human neuronal nuclei. These autoantibodies are indistinguishable from those recently identified in patients with paraneoplastic subacute sensory neuronopathy.
Dropcho
E J
EJ
Department of Neurology, University of Alabama, Birmingham 35294.
Stanton
C
C
Oh
S J
SJ
D000974:Antibodies, Antinuclear / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009474:Neurons / Q000276:immunology*; D013577:Syndrome
D000974:Antibodies, Antinuclear