Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
The present findings show clearly that valproic acid, carbamazepine and phenytoin are each capable of significantly raising serum aspirin-esterase activity in epileptics being treated with these drugs (between p less than 0.01 and p less than 0.05). The data suggest that these antiepileptic drugs may well act as enzymatic-inducing agents upon plasma cholinesterase (or pseudocholinesterase) in epileptic patients.
Puche
E
E
Clinical Pharmacology Unit, University of Granada Hospital, Spain.
Garcia Morillas
M
M
Garcia de la Serrana
H
H
Mota
C
C
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002220:Carbamazepine / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase; D002802:Cholinesterases