Evidence for the involvement of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat.
5-Hydroxy-L-tryptophan (5-HTP), 25 mg kg-1 IP, in combination with the peripheral 5-HTP decarboxylase inhibitor benserazide, 25 mg kg-1 IP, and the selective inhibitor of neuronal 5-hydroxytryptamine (5-HT) re-uptake, zimeldine, 10 mg kg-1 IP, suppressed lordosis in ovariectomized female rats, treated with estradiol benzoate (EB) or with EB plus progesterone (P). The suppression of lordosis produced by 5-HTP was antagonized by the beta-receptor blocker (-)pindolol, which also is a selective 5-HT1 receptor antagonist, but not by the 5-HT2 receptor antagonists metitepine or pirenperone, nor by the beta-receptor blocker betaxolol. The EB- or EB plus P-activated lordosis was also suppressed by administration of the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Together, these observations indicate an important role of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat.
Ahlenius
S
S
Department of Psychology, University of Göteborg, Sweden.
Larsson
K
K
Fernandez-Guasti
A
A
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D015784:Betaxolol; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D008719:Methiothepin / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011187:Posture; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D010880:Piperidines; D011412:Propanolamines; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D004958:Estradiol; D008719:Methiothepin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D010869:Pindolol; D006916:5-Hydroxytryptophan; D015784:Betaxolol; C034177:pirenperone