title: Thyroid hormone regulation of membrane Ca2(+)-ATPase activity.
abstract: The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly on the cell membrane and independent of the cell nucleus. In the case of human erythrocyte Ca2(+)-ATPase, this assay of thyroid hormone bioactivity is attractive as an in vitro, readily-studied model of hormone action in a human cell. Enzyme activity is paralleled, as expected, by changes in calcium pump activity. Thyroid hormone action in this system is subject to modulation by glucose and by a variety of compounds which, like iodothyronines, are hydrophobic. The mechanism of thyroid hormone action on membrane Ca2(+)-ATPase involves, at least in part, membrane lipids, including components of the phosphatidylinositol cycle. The physiologic role of thyroid hormone action on cell membrane Ca2(+)-ATPase is speculative. In plasma membranes of nonexcitable and excitable tissues, ambient thyroid hormone may set basal activity of Ca2(+)-ATPase or magnitude of the enzymatic response to calmodulin Ca2+.
authors.affiliation: Department of Medicine, State University of New York, Buffalo School of Medicine.
authors.forename: P J
authors.initials: PJ
authors.lastname: Davis
authors.forename: F B
authors.initials: FB
authors.lastname: Davis
authors.forename: W D
authors.initials: WD
authors.lastname: Lawrence
mesh_terms: D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology; D006801:Humans; D008954:Models, Biological; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D013963:Thyroid Hormones; D000252:Calcium-Transporting ATPases