The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin.
This review is intended to describe the characteristics of the rat models of non-insulin-dependent diabetes induced by neonatal streptozotocin administration (n-STZ models), to sum-up the information so far collected and to highlight the potential of these models for diabetes research. The n-STZ models can now be recognized as adequate tools for the elucidation of the mechanisms leading to: 1) regeneration of the beta cells, 2) the functional "exhaustion" of the beta cells, 3) the emergence of defects in insulin action. They appear well-suited to study the effects of the modulating factors involved in the appearance and/or deterioration of non-insulin-dependent diabetes (obesity, gestation, content of the diet). They are potentially appropriate for investigations in diabetes pharmacotherapy.
Portha
B
B
Laboratoire de Physiologie du Développement, CNRS UA 307, Université Paris.
Blondel
O
O
Serradas
P
P
McEvoy
R
R
Giroix
M H
MH
Kergoat
M
M
Bailbe
D
D
D000818:Animals; D000831:Animals, Newborn; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage
D013311:Streptozocin