title: In vivo studies of antibody dependent acantholysis.
abstract: The data that are being accumulated on the mechanisms by which pemphigus autoantibodies induce acantholysis in vivo conform that tissue injury in pemphigus is a complex phenomenon where several effector mechanisms may interact. Active research is being performed in many laboratories around the world, employing both in vitro and now in vivo models to further define this unique autoimmune disease.
authors.affiliation: Johns Hopkins University, Baltimore, Maryland.
authors.forename: G J
authors.initials: GJ
authors.lastname: Anhalt
authors.forename: L A
authors.initials: LA
authors.lastname: Diaz
mesh_terms: D000051:Acantholysis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D000954:Antigens, Surface / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology / Q000633:toxicity; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D001938:Brazil; D003167:Complement Activation; D003182:Complement C5 / Q000172:deficiency; D004195:Disease Models, Animal; D004817:Epidermis / Q000276:immunology; D000882:Haplorhini; D007074:Immunoglobulin G / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D010392:Pemphigus / Q000145:classification / Q000276:immunology / Q000473:pathology*; D010960:Plasminogen Activators / Q000502:physiology; D011817:Rabbits
chemical_list: D000305:Adrenal Cortex Hormones; D000954:Antigens, Surface; D001323:Autoantibodies; D003182:Complement C5; D007074:Immunoglobulin G; D010960:Plasminogen Activators