Skin disease in haemophiliacs with and without antibodies to the human immunodeficiency virus (HIV): further evidence of altered disease behaviour in different risk groups?
Forty-one patients routinely attending the Oxford Haemophilia Centre entered a controlled, blind investigation in order to determine whether HIV antibody status was related to the presence of skin disease. Twenty-four of the 41 patients (58.5%) were HIV antibody positive and none had any general symptoms. Comparison of the HIV antibody positive group with the HIV antibody negative group and with non-haemophiliac controls showed an increased prevalence of four HIV-associated dermatoses: 11 patients had seborrhoeic dermatitis (10 HIV antibody positive and one HIV antibody negative (P less than 0.05 chi 2 test], eight patients had folliculitis (six HIV antibody positive), four patients had mucocutaneous candidiasis, all were HIV antibody positive, and three patients had onychomycosis, all were HIV antibody positive. None of these conditions was seen in a group of 16 non-haemophiliac controls. These findings are different from those reported from a similar study of comparable groups of homosexual men and these results may be further evidence to support the belief that the behaviour of HIV infection differs between haemophiliacs and other risk groups.
Telfer
N R
NR
Department of Dermatology, Slade Hospital, Oxford, U.K.
Matthews
J M
JM
Wojnarowska
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D002178:Candidiasis, Chronic Mucocutaneous / Q000209:etiology; D002648:Child; D012628:Dermatitis, Seborrheic / Q000209:etiology; D005499:Folliculitis / Q000209:etiology; D006679:HIV Seropositivity / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000209:etiology; D012307:Risk Factors; D012871:Skin Diseases / Q000209:etiology*