Calcium channel antagonist receptors in cerebral cortex from alcoholic patients.
Exposure to ethanol for days to weeks enhances the expression of voltage-dependent Ca2+ channels in the brains of experimental animals and in cultured neural cell lines. To determine if similar changes occur in the brains of alcoholic patients, we measured the binding of (+)-[3H]PN 200-110 to cerebral cortex samples obtained at autopsy from alcoholic and non-alcoholic patients. No difference in (+)-[3H]PN 200-110 binding was observed, suggesting that ethanol-induced changes in Ca2+ channel expression are more likely to be related to acute withdrawal than to chronic ethanol exposure alone.
Marks
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Department of Neurology, University of California, San Francisco 94110.
Watson
D L
DL
Carpenter
C L
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Messing
R O
RO
Greenberg
D A
DA
D000368:Aged; D000437:Alcoholism / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D017275:Isradipine; D008875:Middle Aged; D010069:Oxadiazoles / Q000378:metabolism*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D010069:Oxadiazoles; D017275:Isradipine