title: Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
abstract: The effects of peripheral benzodiazepines on the respiration of a neuronal cell, the mouse C 1300 neuroblastoma, were analyzed. The presence of 'peripheral receptors' to the [3H]PK 11195 ligand was checked in these cells. A dose-dependent decrease of the O2 consumption in the presence of Ro 5-4864 and PK 11195 was observed at concentrations consistent with a receptor-mediated action. Diazepam, clonazepam and Ro 15-1788 were inactive. Previous studies have localized the peripheral benzodiazepine receptors on the mitochondrial outer membrane. We report here an effect of the peripheral ligand on mitochondrial metabolism.
authors.affiliation: Laboratoire de Biochimie Cellulaire, Collège de France, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Larcher
authors.forename: J L
authors.initials: JL
authors.lastname: Vayssiere
authors.forename: F J
authors.initials: FJ
authors.lastname: Le Marquer
authors.forename: L R
authors.initials: LR
authors.lastname: Cordeau
authors.forename: P E
authors.initials: PE
authors.lastname: Keane
authors.forename: A
authors.initials: A
authors.lastname: Bachy
authors.forename: F
authors.initials: F
authors.lastname: Gros
authors.forename: B P
authors.initials: BP
authors.lastname: Croizat
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D002478:Cells, Cultured; D002998:Clonazepam / Q000494:pharmacology; D002999:Clone Cells; D003975:Diazepam / Q000494:pharmacology; D005442:Flumazenil / Q000378:metabolism; D007546:Isoquinolines / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism
chemical_list: D007546:Isoquinolines; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; D002998:Clonazepam; D003975:Diazepam; C037850:PK 11195