title: Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull.
abstract: Sixty-eight patients with chordoma or low-grade chondrosarcoma at the base of the skull received fractionated high-dose postoperative radiation delivered with a 160-MeV proton beam. Protons have favorable physical characteristics which allow the delivery of high doses of radiation to these critically located tumors. The methods employed for these treatments are described. These patients have been followed for at least 17 months and for a median of 34 months. The median tumor dose was 69 CGE (cobalt Gy equivalent): CGE is the dose in proton Gy multiplied by 1.1, which is the relative biological effectiveness for protons compared to cobalt-60. The daily dose was 1.8 to 2.1 CGE. For this group the 5-year actuarial local control rate is 82% and disease-free survival rate is 76%. The incidence of treatment-related morbidity has been acceptable.
authors.affiliation: Department of Radiation Medicine, Massachusetts General Hospital, Boston.
authors.forename: M
authors.initials: M
authors.lastname: Austin-Seymour
authors.forename: J
authors.initials: J
authors.lastname: Munzenrider
authors.forename: M
authors.initials: M
authors.lastname: Goitein
authors.forename: L
authors.initials: L
authors.lastname: Verhey
authors.forename: M
authors.initials: M
authors.lastname: Urie
authors.forename: R
authors.initials: R
authors.lastname: Gentry
authors.forename: S
authors.initials: S
authors.lastname: Birnbaum
authors.forename: D
authors.initials: D
authors.lastname: Ruotolo
authors.forename: P
authors.initials: P
authors.lastname: McManus
authors.forename: S
authors.initials: S
authors.lastname: Skates
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002813:Chondrosarcoma / Q000532:radiotherapy*; D002817:Chordoma / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011522:Protons; D011832:Radiation Injuries; D012888:Skull Neoplasms / Q000532:radiotherapy*; D014786:Vision Disorders / Q000209:etiology
chemical_list: D011522:Protons