Magnesium monoperoxophtalate: an efficient single oxygen atom donor in DNA cleavage catalyzed by metalloporphyrin.
The peracid compound magnesium monoperoxophtalate (MMPP), water-soluble at physiological pH, behaves as a promising oxygen donor in the oxidative cleavage of DNA catalyzed by meso-tetrakis-(4-N-methylpyridyl)porphyrinatomanganese(III) pentaacetate. Shown on cleavage of supercoiled phi X174 DNA, MMPP is significantly more efficient than KHSO5, another recently developed single oxygen atom donor (Fouquet et al., J. Chem. Soc., Chem. Commun., 1987, 1169).
Pratviel
G
G
Laboratoire de Chimie de Coordination du CNRS, Toulouse, France.
Bernadou
J
J
Ricci
M
M
Meunier
B
B
D010584:Bacteriophage phi X 174 / Q000235:genetics; D002384:Catalysis; D004278:DNA, Superhelical / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008345:Manganese; D008665:Metalloporphyrins / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism*; D010795:Phthalic Acids; D013464:Sulfuric Acids / Q000378:metabolism
D004278:DNA, Superhelical; D004279:DNA, Viral; D008665:Metalloporphyrins; D010545:Peroxides; D010795:Phthalic Acids; D013464:Sulfuric Acids; D008345:Manganese; C050950:tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex; C048813:potassium peroxymonosulfuric acid; D010100:Oxygen; C044731:magnesium monoperoxyphthalate