Role of atrial natriuretic peptide on sodium homeostasis in experimental renal failure.
In a study of the role of atrial natriuretic peptide (ANP) in sodium homeostasis in experimental renal failure, we found that a infusion of ANP at 0.25 microgram/min for 15 min produced an increase in the glomerular filtration rate (GFR) and fractional excretion of sodium (FENa) in five-sixth nephrectomized (5/6 Nx) rats. Renal vascular resistance (RVR) was lower during the base-line period and did not change after the administration of 100 ng/ml ANP to isolated perfused kidney (IPK) from adriamycin-treated rats. Furthermore, fractional excretion of ANP (FEANP) by IPK decreased in kidneys from adriamycin-treated rats as compared to that in kidneys from control rats. Finally, after 5/6 Nx, levels of plasma immunoreactive ANP (ir-ANP) gradually increased but excretion of water and sodium did not change during normal intake of sodium. The increase in levels of ir-ANP was accompanied by an increase in the rates of excretion of water and sodium was observed 2 days later but these rates returned to the base-line values after 2 weeks. These findings suggest that ANP plays an important role in the adjustment of acute changes in the volume of extracellular fluid during experimental renal failure.
Nitta
K
K
Department of Medicine, Tokyo Women's Medical College, Japan.
Naruse
M
M
Sanaka
T
T
Tsuchiya
K
K
Sugino
N
N
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006706:Homeostasis; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects
D004317:Doxorubicin; D009320:Atrial Natriuretic Factor; D012964:Sodium