title: [Kidney function in heart failure].
abstract: Congestive cardiac failure is a syndrome in which a decrease of cardiac output triggers a series of neuro-humoral compensatory mechanisms in part involving the kidney. In this response, dysfunction of atrial volume receptors as well as disturbances of the autonomic nervous system have recently been demonstrated and are held responsible for excessive stimulation of angiotensin II, followed by adverse regulatory effects. Renal hemodynamic compensation for heart failure primarily involves constriction of efferent arterioles thereby defending glomerular filtration. In this setting, the occurrence of prerenal insufficiency is indicative of a far advanced reduction in renal blood flow. Apparent diuretic resistance in the treatment of heart failure is usually caused by iatrogenic vascular compromise or by the use of a single diuretic rather than an appropriate combination. Hyponatremia, vasopressin stimulation and elevation of plasma N-epinephrine concentration have been found to be the most reliable indicators of a poor prognosis of heart failure. Atrial natriuretic peptide is stimulated in proportion to the degree of atrial distension in heart failure, however its intrarenal effects are markedly blunted or may even be absent in this particular disease.
authors.affiliation: Abteilung Innere Medizin und Nephrologie, Klinikum Steglitz Freien Universität Berlin.
authors.forename: P
authors.initials: P
authors.lastname: Gross
authors.forename: A
authors.initials: A
authors.lastname: Wichmann
authors.forename: M
authors.initials: M
authors.lastname: Ketteler
authors.forename: J
authors.initials: J
authors.lastname: Hensen
authors.forename: A
authors.initials: A
authors.lastname: Schömig
mesh_terms: D009320:Atrial Natriuretic Factor / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D012079:Renal Circulation; D014882:Water-Electrolyte Balance
chemical_list: D009320:Atrial Natriuretic Factor
vernacular_title: Nierenfunktion bei Herzinsuffizienz.