Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosides.
In a case of motor-dominant neuropathy and IgM paraproteinemia, the binding specificity of the serum IgM M-protein was characterized by enzyme-linked immunosorbent assay (ELISA). The serum IgM M-protein bound preferentially to ganglioside GM1 with slight cross-reactivity to both GM2 and GD1b. The binding specificity of the antibody and clinicopathological features are discussed.
Kusunoki
S
S
Department of Neurology, School of Medicine, University of Tokyo, Japan.
Shimizu
T
T
Matsumura
K
K
Maemura
K
K
Mannen
T
T
D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000150:complications* / Q000378:metabolism; D010265:Paraproteinemias / Q000150:complications* / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000378:metabolism
D005732:Gangliosides; D007075:Immunoglobulin M