title: [Evaluation of the antalgic activity and tolerability of piroxicam in chronic pain in cervicoarthrosis and lumboarthrosis].
abstract: A study was carried out to assess the analgesic efficacy and the safety of piroxicam and to compare them with those of a piroxicam derivative, piroxicam beta-cyclodextrin, in chronic pain caused by arthritis of the neck and lower back. The drugs in question were administered for two weeks at the dose of 20 mg/die per os to 63 patients, 32 of whom were treated with the original molecule and the remaining subjects with its derivative. The study protocol scheduled assessments of pain and its reduction at baseline and after three, seven, and fourteen days of treatment. At the end of the two weeks of treatment, the drugs' efficacy and safety were evaluated. The results confirmed piroxicam's efficacy and safety in pain of the neck and lower back caused by osteoarthritis and did not show any differences, for the parameters examined, between the original molecule and its derivative.
authors.forename: G
authors.initials: G
authors.lastname: Minisola
authors.forename: B
authors.initials: B
authors.lastname: Dardano
mesh_terms: D000328:Adult; D000368:Aged; D002574:Cervical Vertebrae; D002908:Chronic Disease; D003505:Cyclodextrins / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000150:complications; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010894:Piroxicam / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010894:Piroxicam; C031215:betadex
vernacular_title: Valutazione dell'attività antalgica e della tollerabilità del piroxicam nel dolore cronico da cervicoartrosi e da lombartrosi.