Activity-dependent enhancement of presynaptic inhibition in Aplysia sensory neurons.
Tail shock produces transient presynaptic inhibition and longer lasting presynaptic facilitation of the siphon sensory neurons in Aplysia. The facilitation undergoes activity-dependent enhancement that is thought to contribute to classical conditioning of the gill- and siphon-withdrawal reflex. Inhibition of the sensory neurons has now also been shown to undergo activity-dependent enhancement when action potential activity in the sensory neurons is paired with inhibitory transmitter. This effect appears to involve an amplification of the same cellular mechanisms that are involved in normal presynaptic inhibition. These results suggest that activity-dependent enhancement may be a general type of associative cellular mechanism.
Small
S A
SA
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Kandel
E R
ER
Hawkins
R D
RD
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D019835:FMRFamide; D007858:Learning / Q000502:physiology*; D009433:Neural Inhibition; D009475:Neurons, Afferent / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology; D013570:Synaptic Membranes / Q000502:physiology
D015220:Calcium Channels; D009479:Neuropeptides; D015221:Potassium Channels; D019835:FMRFamide