Tissue site-specific enhancer function of the upstream regulatory region of human papillomavirus type 11 in cultured keratinocytes.
The human papillomavirus type 11 regulatory region was cloned upstream of a reporter complex and microinjected into nuclei of individual primary human keratinocytes. Genital and laryngeal keratinocytes, normal host cells for this virus, exhibited higher levels of expression than cutaneous keratinocytes. We conclude that a papillomavirus enhancer(s) shows preferences among epithelial cells from different tissue sites.
Steinberg
B M
BM
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Auborn
K J
KJ
Brandsma
J L
JL
Taichman
L B
LB
D000957:Antigens, Viral, Tumor / Q000096:biosynthesis; D002478:Cells, Cultured; D004742:Enhancer Elements, Genetic; D000078404:Epidermal Cells; D004848:Epithelium / Q000382:microbiology; D005814:Genes, Viral; D006801:Humans; D007830:Larynx / Q000166:cytology; D008297:Male; D009928:Organ Specificity; D027383:Papillomaviridae / Q000235:genetics* / Q000502:physiology; D010413:Penis / Q000166:cytology; D014779:Virus Replication
D000957:Antigens, Viral, Tumor