title: Osteosclerotic myeloma with polyneuropathy and hypocalcemia.
abstract: A case is presented of a 46-year-old man with multifocal osteosclerotic bone lesions, peripheral polyneuropathy and hypocalcemia. Histologic examination of a bone marrow biopsy disclosed a multiple myeloma. Immunoelectrophoresis revealed a small M-component identified as IgG-lambda. Osteosclerotic myeloma lacking any osteolytic lesions seems to be very rare and shows several different features as compared with classical myeloma. A review of the current literature suggests that multiple myeloma is not a uniform disease but rather a group of clinical syndromes characterized by the special properties of their proliferating plasma cell clones.
authors.affiliation: Department of Pathology, University of Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Ludescher
authors.forename: K
authors.initials: K
authors.lastname: Grünewald
authors.forename: F
authors.initials: F
authors.lastname: Fend
authors.forename: O
authors.initials: O
authors.lastname: Dietze
authors.forename: J
authors.initials: J
authors.lastname: Thaler
authors.forename: K W
authors.initials: KW
authors.lastname: Schmid
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D006996:Hypocalcemia / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D010026:Osteosclerosis / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D013577:Syndrome