title: Endocrine effects of laparoscopic ovarian electrocautery in patients with polycystic ovarian disease, resistant to clomiphene citrate.
abstract: Endocrine responses to laparoscopic ovarian electrocautery were studied in 14 patients with polycystic ovarian disease (PCOD), resistant to clomiphene citrate. Patients who did not conceive within 6 months of treatment were evaluated for up to that period. Testosterone and androstenedione levels decreased after electrocautery in a way which is comparable with the reduction in androgens after wedge resection of the ovary. Androstenedione levels tended to return to pretreatment values at 6 months; four of the five pregnancies were achieved within this period. The reduction in androgens may break the vicious circle of PCOD, and lead to normal menstrual cycles.
authors.affiliation: Department of Obstetrics and Gynaecology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: van der Weiden
authors.forename: A T
authors.initials: AT
authors.lastname: Alberda
authors.forename: F H
authors.initials: FH
authors.lastname: de Jong
authors.forename: H
authors.initials: H
authors.lastname: Brandenburg
mesh_terms: D002996:Clomiphene / Q000494:pharmacology; D004564:Electrocoagulation; D005069:Evaluation Studies as Topic; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D010535:Laparoscopy; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000601:surgery*; D011247:Pregnancy; D011863:Radioimmunoassay
chemical_list: D012739:Gonadal Steroid Hormones; D002996:Clomiphene