Inhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnet.
We describe a synergistic effect of combinations of foscarnet and 3'-azido-3'-deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3'-azido-3'-deoxythymidine triphosphate against human immunodeficiency virus type 1 reverse transcriptase, and a low toxicity in cell culture of combinations of the two drugs.
Koshida
R
R
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
Vrang
L
L
Gilljam
G
G
Harmenberg
J
J
Oberg
B
B
Wahren
B
B
D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D017245:Foscarnet; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D015215:Zidovudine / Q000494:pharmacology* / Q000633:toxicity
D000998:Antiviral Agents; D009943:Organophosphorus Compounds; D017245:Foscarnet; D015215:Zidovudine; D010746:Phosphonoacetic Acid