Influence of dietary phosphorus restriction on calcium and phosphorus metabolism in rats.
The effect of dietary phosphorus (P) on calcium (Ca) and phosphorus metabolism was studied in young female rats. P levels in the semipurified diets ranged from 0.1 to 0.4% (w/w). A level of 0.4% P in the diet is recommended for rats. Kidney calcification was observed in rats fed the 0.4%-P diet whereas P restriction prevented this condition. Rats fed the diet containing 0.1% P, showed severe hypercalciuria, hypercalcemia, reduced growth and impaired bone mineralization. These effects did not occur when the diet contained 0.2 or 0.3% of P. This study suggests that in short-term studies P in the diet of female rats can be restricted to 0.2% so as to prevent nephrocalcinosis without affecting their development.
Schoenmakers
A C
AC
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Ritskes-Hoitinga
J
J
Lemmens
A G
AG
Beynen
A C
AC
D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D004032:Diet; D004435:Eating; D005260:Female; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D008657:Metabolic Clearance Rate; D008903:Minerals / Q000378:metabolism; D009397:Nephrocalcinosis / Q000209:etiology* / Q000517:prevention & control; D010758:Phosphorus / Q000172:deficiency* / Q000378:metabolism; D051381:Rats; D013047:Specific Pathogen-Free Organisms
D008903:Minerals; D010758:Phosphorus; D002118:Calcium