[Changes in cerebellar iron metabolism and their prevention by allopurinol in oxidative stress related to acute ethanol administration in rats].
An acute ethanol load results in an increased total nonheme iron and cytosolic low molecular weight iron content in rat cerebellum. At the same time the cerebellar susceptibility to lipid peroxidation is enhanced whereas the alpha-tocopherol and ascorbate content is decreased. These changes argue for a cerebellar ethanol-induced oxidative stress, which is prevented by prior allopurinol administration.
Rouach
H
H
Département de Recherches Biomédicales sur l'Alcoolisme, Université René-Descartes, Paris.
Houzé
P
P
Park
M
M
Nordmann
R
R
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D002531:Cerebellum / Q000032:analysis*; D000431:Ethanol / Q000009:adverse effects*; D007501:Iron / Q000032:analysis*; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000139:chemically induced* / Q000378:metabolism; D014810:Vitamin E / Q000032:analysis
D008054:Lipid Peroxides; D014810:Vitamin E; D000431:Ethanol; D000493:Allopurinol; D007501:Iron; D001205:Ascorbic Acid
Altérations du métabolisme cérébelleux du fer et leur prévention par l'allopurinol lors du stress oxydatif lié à l'administration aiguë d'éthanol chez le rat.