[Na+/H+ metabolic activity in the thrombocytes of spontaneously hypertensive rats].
The sodium-proton exchange was determined in platelets of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The platelets were suspended in sodium propionate; the cytoplasmic acidification activated the exchanger and intracellular pH (the increasing) and volume of the platelets (the swelling) were registered. The activity of Na+/H+ exchange was inhibited by isopropyl amiloride. The platelets' volume and the exchange rate constant of SHR were increased on 30-40% as compared with those of WKY.
Markov
Kh M
KhM
Pinelis
V G
VG
Kudinov
Iu V
IuV
Borin
M L
ML
Azizova
O A
OA
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D006859:Hydrogen / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D011522:Protons; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood*
D011522:Protons; D006859:Hydrogen; D012964:Sodium
Aktivnost' Na+/H+-obmena v trombotsitakh spontanno gipertenzivnykh krys.