Vasocystostomy: a model for studying male reproductive toxicity in the rat.
A nonsacrificial rat model has been developed which permits the easy collection and measurement of spermatozoa. The ductus deferens is anastomosed to the bladder (Vasocystostomy) and urinary sperm is collected daily. The correlation between testicular histology and sperm counts indicates that this model is reliable. Using this model we demonstrate inhibition of sperm production by fluoroacetate.
al-Juburi
A Z
AZ
Department of Urology, University of Arkansas College of Medicine, Little Rock 72205.
Clarkson
T W
TW
Cockett
A T
AT
D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D005463:Fluoroacetates / Q000633:toxicity; D007248:Infertility, Male / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count / Q000187:drug effects; D013737:Testis / Q000473:pathology; D001743:Urinary Bladder / Q000502:physiology / Q000601:surgery*; D014556:Urine / Q000166:cytology*; D014649:Vas Deferens / Q000502:physiology / Q000601:surgery*
D005463:Fluoroacetates