title: Technetium-99m MAG-3 clearances after captopril in experimental renovascular hypertension.
abstract: Rats with one kidney clamped (2K1C), both kidneys clamped (2K2C), unilaterally nephrectomized with remaining kidney clamped (1K1C), and normals, were studied using 99mTc mercaptoacetyltriglycine ([ 99mTc]MAG-3) and 131I orthoiodohippurate ([131I]OIH). Clearances of [99mTc]MAG-3 and [131I]OIH were performed after constricted rats became hypertensive. Clearances were repeated after i.v. Captopril. Clearances of [99mTc]MAG-3 and [131I]OIH in normals didn't change significantly after Captopril. Clearances of [99mTc]MAG-3 and [131I]OIH decreased insignificantly after Captopril in the 2K2C model. in the 2K1C group, normal kidney clearance increased ([99mTc]MAG-3 p less than 0.01 and [131I]OIH p less than 0.025) and clamped kidney clearance decreased after inhibition ([99mTc]MAG-3, p less than 0.01, [131I]OIH p less than 0.02). Clearances increased in the 1K1C group after Captopril ([99mTc]MAG-3 p less than 0.0025 and [131I]OIH, p less than 0.001). The ratio of [99mTc]MAG-3 to [131I]OIH before Captopril was 0.81 and 0.84 after Captopril. Changes in renal function after Captopril depend on the model of renovascular hypertension and possibly the dose administered. Technetium-99m MAG-3 clearance parallels [131I]orthoiodohippurate in renovascular hypertension.
authors.affiliation: Department of Nuclear Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10461.
authors.forename: H B
authors.initials: HB
authors.lastname: Lee
authors.forename: M D
authors.initials: MD
authors.lastname: Blaufox
mesh_terms: D000818:Animals; D002216:Captopril; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000378:metabolism*; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D008297:Male; D009392:Nephrectomy; D009842:Oligopeptides / Q000493:pharmacokinetics*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000493:pharmacokinetics*; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium; D002216:Captopril