title: Concomitant augmentation of CD4+ CD45R+ suppressor/inducer subset and diminution of CD4+ CDw29+ helper/inducer subset during rush hyposensitization in hymenoptera venom allergy.
abstract: A longitudinal study of patients undergoing rush hyposensitization by honey-bee or yellow jacket venom revealed significant changes of the immunophenotypes until the optimal dose was reached, and a progressive reversion to pre-treatment values in the following months. The activation markers CD23 on B cells and CD25 (IL-2 receptor) on T and B lymphocytes decreased. Although there was little variation of the major CD4 and CD8 lymphocyte populations, CD45R+ cells increased whilst CDw29+ lymphocytes diminished. This inverse variation was associated with a peak of CD4+ CD45R+ cells with concomitant decrease in CD4+ CDw29+ cells showing an inverse effect of the treatment on the reciprocal subsets of CD4 lymphocytes. This indicates a shift in the suppressor/inducer to helper/inducer cell ratio early during rush hyposensitization which may also suggest reversion into a less mature stage of CD4+ cells, associated with the transition from a highly allergen-reactive state to progressive unresponsiveness.
authors.affiliation: Unite Mixte INSERM U167-CNRS 624, Institut Pasteur, Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Tilmant
authors.forename: J P
authors.initials: JP
authors.lastname: Dessaint
authors.forename: A
authors.initials: A
authors.lastname: Tsicopoulos
authors.forename: A B
authors.initials: AB
authors.lastname: Tonnel
authors.forename: A
authors.initials: A
authors.lastname: Capron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000517:prevention & control; D000943:Antigens, Differentiation / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001514:Bee Venoms / Q000276:immunology; D002648:Child; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy*; D017493:Leukocyte Common Antigens; D007958:Leukocyte Count; D008875:Middle Aged; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification*; D050378:T-Lymphocytes, Regulatory / Q000145:classification*; D014862:Wasp Venoms / Q000276:immunology
chemical_list: D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D001514:Bee Venoms; D014862:Wasp Venoms; D017493:Leukocyte Common Antigens