[Prognostic significance of DNA ploidy and distribution of cell cycle phases in non-small cell bronchial cancer. A 5-year survival study].
Non-small cell lung carcinomas represent a mixed group of tumors with overlapping histologies, clinical courses and responses to treatment. Thus, an accurate prediction of tumor progression and patient survival remains a major problem for these tumors. The aim of the present study, therefore, was to look for cellular prognostic indicators in addition to the well known clinical prognostic factors. Fresh surgical specimens of tumors of 187 patients with previously untreated non-small cell lung carcinomas were investigated by means of flow cytometry. Patients with aneuploid tumors had significantly shorter survival times than did those with diploid tumors. Patients with tumors with a high proliferative activity died significantly earlier than patients with lower proliferative activity. Identical results are obtained when the analysis is restricted to just those patients with T3 tumors or to patients with metastatic tumors at time of surgery or were classified Stage III. These data indicate that DNA ploidy and distribution of cell cycle phase are strong and independent prognostic factors for the survival of patients with non-small cell lung carcinoma. All patients had a minimum of 5 years follow up.
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D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm
Prognostische Bedeutung der DNS-Ploidie und der Verteilung der Zellzyklus-Phasen beim nichtkleinzelligen Bronchialkarzinom. Eine 5-Jahres-Uberlebenszeit-Studie.