[Frequency-related blocking of sodium channels in the membrane of isolated rat cardiomyocytes by the calcium antagonist verapamil].
Use-dependent blocking of sodium current in the membrane of single rat cardiomyocytes by verapamil (in the concentration range of 5-50 mumol/l) has been observed. The data obtained suggest that verapamil binding with sodium channels which are in the open or inactivated state underlies suppression of sodium current.
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D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009206:Myocardium / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D015222:Sodium Channels; D014700:Verapamil
Chastotno-zavisimoe blokirovanie natrievogo toka membrany izolirovannykh kardiomiotsitov krys kal'tsievym antagonistom verapamilom.