Cytogenetic studies in 11 patients with small cell carcinoma of the lung.
Small cell carcinoma of the lung has reportedly been associated with structural abnormalities of the short arm of chromosome 3, but most of the previous studies were done on long-term cultures that involved cell lines. In the current study, we investigated the chromosome abnormalities in specimens from primary lung tumors grown in short-term cultures. Cytogenetic studies were done in 11 patients with small cell carcinoma of the lung, and a chromosomally abnormal clone was observed in each tumor. An abnormality of chromosome 3 was observed in six of these tumors.
De Fusco
P A
PA
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
Frytak
S
S
Dahl
R J
RJ
Weiland
L H
LH
Unni
K K
KK
Dewald
G W
GW
D000368:Aged; D000782:Aneuploidy; D018288:Carcinoma, Small Cell / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic