[DNA topoisomerases and resistance to anticancer agents].
Since the discovery of several potent anticancer agents which are specific inhibitors of DNA topoisomerases, the key enzymes in the DNA metabolism, efforts to elucidate the mechanism of acquired resistance to these agents and to overcome them have been focused on these enzymes, the cellular targets of the anticancer agents. These trends were briefly reviewed.
Andoh
T
T
Meiji College of Pharmacy, Division of Blood Transfusion, Hiroshima University Hospital.
Okada
K
K
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000201:enzymology / Q000473:pathology; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
D000970:Antineoplastic Agents; D059004:Topoisomerase I Inhibitors; D002166:Camptothecin