Effects of glipizide on beta-endorphin concentration in the brain of genetically diabetic (db/db) mice.
Sulphonylurea drugs have been shown to augment glucose metabolism by both pancreatic and extrapancreatic actions. The regulation of glucose involves a modification of beta-endorphin secretions via central and peripheral mechanisms. beta-Endorphin participates in the regulation of feeding and is implicated both in obesity and diabetes mellitus. This study shows that glipizide could exert its pharmacological action in genetically diabetic (db/db) mice via beta-endorphin secretions by a central mechanism.
Belon
J P
JP
Laboratory of Pharmacology, University of Franche-Comté, Besançon, France.
Orosco
M
M
Henry
J C
JC
Jacquot
C
C
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005913:Glipizide / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D007328:Insulin / Q000097:blood; D051379:Mice; D008817:Mice, Mutant Strains; D010902:Pituitary Gland / Q000378:metabolism; D012016:Reference Values; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D001615:beta-Endorphin / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D013453:Sulfonylurea Compounds; D001615:beta-Endorphin; D005913:Glipizide