Comparison between intra- and extracellular surfactant in respiratory distress induced by oleic acid.
The present study compares the phospholipid distribution and protein content in bronchoalveolar lavage, purified extracellular surfactant and lamellar bodies isolated from rabbits killed at intervals of 2.5, 12 and 24 h after oleic acid administration. The data suggest that the alteration of pulmonary surfactant could be partially due to the type II cell response to the injury.
Casals
C
C
Department of Biochemistry, Faculty of Chemistry, Universidad Complutense, Madrid, Spain.
Herrera
L
L
Miguel
E
E
Garcia-Barreno
P
P
Municio
A M
AM
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D002479:Inclusion Bodies / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids; D010743:Phospholipids / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism
D008244:Lysophosphatidylcholines; D009829:Oleic Acids; D010743:Phospholipids; D011663:Pulmonary Surfactants; D013109:Sphingomyelins; D019301:Oleic Acid