title: Secondary depression in panic disorder and agoraphobia. II. Dimensions of depressive symptomatology and their response to treatment.
abstract: Secondary depressive symptomatology in 435 subjects with panic disorder and phobic avoidance was studied before and after alprazolam treatment. No subject who had a primary affective disorder was included. Calculation of Hamilton Depression Rating Scale factor scores revealed that the agitation/anxiety, sleep disturbance, and somatization factors accounted for approximately 75% of the HAM-D total score; these all showed significant improvement with alprazolam treatment. There were few differences in dimensions of depressive symptomatology between those subjects with and those without major depression; the main difference was in the overall intensity of the depression.
authors.affiliation: Department of Psychiatry, Harbor-UCLA Medical Center, Torrance.
authors.forename: I M
authors.initials: IM
authors.lastname: Lesser
authors.forename: R T
authors.initials: RT
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Rifkin
authors.forename: R P
authors.initials: RP
authors.lastname: Swinson
authors.forename: J C
authors.initials: JC
authors.lastname: Ballenger
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
authors.forename: R L
authors.initials: RL
authors.lastname: Dupont
authors.forename: R
authors.initials: R
authors.lastname: Noyes
authors.forename: J C
authors.initials: JC
authors.lastname: Pecknold
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000379:Agoraphobia / Q000188:drug therapy* / Q000523:psychology; D000525:Alprazolam / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*; D010698:Phobic Disorders / Q000188:drug therapy*; D011581:Psychological Tests
chemical_list: D000525:Alprazolam