Malaria prophylaxis during military operations in Thailand.
Thai soldiers deployed along the Thai-Kampuchean border experience high attack rates of drug-resistant falciparum malaria. Adequate drug prophylaxis has proven difficult with the failure of chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/dapsone. Under some circumstances, mefloquine, doxycycline, and proguanil/sulfamethoxazole can successfully prevent falciparum malaria in Thailand. Decisions regarding chemoprophylaxis drugs in Thailand depend on a complex interaction of effectiveness, compliance, side effects, and long-term usefulness.
Shanks
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Karwacki
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Singharaj
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D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004318:Doxycycline / Q000008:administration & dosage; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D015767:Mefloquine / Q000008:administration & dosage; D008889:Military Personnel; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage; D013785:Thailand
D000962:Antimalarials; D013420:Sulfamethoxazole; D004318:Doxycycline; D002727:Proguanil; D015767:Mefloquine