title: T-cell populations in liver and renal transplant recipients with infectious esophagitis.
abstract: Individuals undergoing hepatic and renal transplants are susceptible to infections of the gastrointestinal tract, particularly the esophagus. The most common responsible agents are Candida and herpes simplex virus (HSV) with cytomegalovirus (CMV), Aspergillus, and other agents being regarded as unusual pathogens even in this unique population. Altered T-cell populations have been associated with CMV colitis in healthy homosexuals and in individuals with the acquired immunodeficiency syndrome (AIDS). Similarly, individuals with Epstein-Barr virus infections have altered T-cell populations. Whether these infections alter T-cell populations in infected individuals or the abnormalities in T-cell subpopulations occur first and enhance the likelihood of an infection in susceptible populations is as yet unknown. In this study peripheral blood T-cell populations in individuals before (19 patients) and after (47 patients) liver transplantation and after receiving a renal allograft (21 patients) were compared. Those individual having any symptoms related to esophageal disease underwent upper gastrointestinal endoscopy combined with mucosal biopsies, brushings, and cultures and were subdivided into those with and without infectious esophagitis. CMV esophagitis was found to be associated with an arithmetically decreased T-cell helper/suppressor (H/S) ratio principally due to an increase in the suppressor cell number. Such a reduction in the TH/S ratio and in the number of circulating suppressor cells was not found in esophagitis due to either HSV or Candida and was unrelated to the serum cyclosporine level or prednisone dosage prescribed.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: University of Pittsburgh, School of Medicine, Pennsylvania.
authors.forename: D E
authors.initials: DE
authors.lastname: Brouillette
authors.forename: J
authors.initials: J
authors.lastname: Alexander
authors.forename: Y K
authors.initials: YK
authors.lastname: Yoo
authors.forename: M C
authors.initials: MC
authors.lastname: Chien
authors.forename: R E
authors.initials: RE
authors.lastname: Tarter
authors.forename: J
authors.initials: J
authors.lastname: Gavaler
authors.forename: D H
authors.initials: DH
authors.lastname: Van Thiel
mesh_terms: D000328:Adult; D002177:Candidiasis / Q000276:immunology*; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000276:immunology*; D004941:Esophagitis / Q000209:etiology* / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000145:classification*
chemical_list: D003524:Cyclosporins; D011241:Prednisone