Atrial natriuretic peptide inhibits the release of endothelium-derived relaxing factor from blood vessels of the rabbit.
We investigated the effects of atrial natriuretic peptide (ANP) on release of endothelium-derived relaxing factor (EDRF) from rabbit aorta and central ear artery using inhibition of platelet aggregation and vascular smooth muscle relaxation respectively as measures of EDRF activity. ANP at concentrations greater than 10(-9) M inhibited carbachol-induced EDRF release from rabbit aorta and acetylcholine-induced EDRF release from the central ear artery. These findings are consistent with previous observations that 8-bromo cyclic GMP inhibits EDRF release from rabbit aorta and ANP inhibits release of EDRF from cultured endothelial cells.
Hogan
J C
JC
Department of Cardiology, University of Wales College of Medicine, Cardiff, U.K.
Smith
J A
JA
Richards
A C
AC
Lewis
M J
MJ
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001685:Biological Factors / Q000378:metabolism*; D004423:Ear / Q000098:blood supply; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide; D010656:Phenylephrine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D001685:Biological Factors; D010656:Phenylephrine; D009569:Nitric Oxide; D000244:Adenosine Diphosphate; D009320:Atrial Natriuretic Factor