Ten families of ankylosing spondylitis.
Twenty-two patients with ankylosing spondylitis (AS) from 10 families were studied with special attention to their clinical findings, HLA-B27 examinations and family histories. Results showed that HLA-B27 was positive in 19 and negative in 3. The hereditary relationship between ankylosing spondylitis and HLA-B27 in Chinese was similar to that in westerners. We consider that subjective symptoms and clinical findings are essential to early diagnosis of AS, but HLA-B27 examination and family history are supportive.
Fu
X
X
Wang
J C
JC
Jia
Y M
YM
Kang
Q
Q
An
J B
JB
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D015796:HLA-B27 Antigen