title: [Probable side effects caused by plethoryl. Common acute hepatitis, anicteric hepatitis, cirrhosis due to hypervitaminosis A, inflammatory arthralgias].
abstract: Plethoryl is a combination of triatricol, cyclovalone and vitamin A normally prescribed in the treatment of hypercholesterolaemia. Four cases of side-effects most probably caused by this product are reported. They include: 1) a case of common acute hepatitis, 23 cases of which have already been published, with aggravation and reduced time-lapse after reintroduction; 2) a case of clinically silent but biochemically classical hepatitis; 3) a case of cirrhosis due to vitamin A toxicity; 4) a case of inflammatory arthralgias recurring after the same time-lag when the drug was reintroduced despite double doses and without clinical evidence of hepatitis. The last three side-effects have never been previously reported. The adverse reactions to Plethoryl almost always occur in the unofficial indications of the product, notably in the "treatment" of obesity.
authors.affiliation: Clinique St Joseph, Angoulême.
authors.forename: B
authors.initials: B
authors.lastname: Maroy
authors.forename: P
authors.initials: P
authors.lastname: Moullot
authors.forename: J M
authors.initials: JM
authors.lastname: Constantin
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003510:Cyclohexanes / Q000009:adverse effects*; D003512:Cyclohexanones / Q000009:adverse effects* / Q000627:therapeutic use; D004224:Diterpenes; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications*; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D014284:Triiodothyronine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014801:Vitamin A / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003510:Cyclohexanes; D003512:Cyclohexanones; D004224:Diterpenes; D004338:Drug Combinations; D014284:Triiodothyronine; C044594:Plethoryl; D014801:Vitamin A
vernacular_title: Effets secondaires probablement dus au Pléthoryl. Hépatite aiguë habituelle, hépatite anictérique, cirrhose par hypervitaminose A, arthralgies inflammatoires.