[Infection of T lymphocytes by Trypanosoma cruzi. Possible role of CD3 and HLA-DR].
The mechanisms by which the causative agent of Chagas' disease impair its host's immune response are of paramount importance but poorly understood. Results presented in this paper show for the first time that Trypanosoma cruzi trypomastigotes infect T lymphocytes in vitro and more interestingly in vivo, and that trypomastigotes released from infected cells are infectious. In addition treatment of purified human T lymphocytes with McAb against CD3 and HLA-DR antigens significantly inhibited parasite infection. T. cruzi antigens were detected on the membrane of infected T cells and could therefore represents targets for cytotoxic mechanisms. These results might have important consequences for the understanding of the dramatic disruption of immune response observed during Chagas' disease and more generally provide additional information on T lymphocyte infection by pathogens.
Velge
P
P
Centre d'Immunologie et de Biologie parasitaire, Unité mixte I.N.S.E.R.M., Un. 167, C.N.R.S. n. 624, Institut Pasteur, Lille.
Ouaissi
A
A
Kusnierz
J P
JP
Capron
A
A
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000953:Antigens, Protozoan / Q000032:analysis; D001402:B-Lymphocytes / Q000469:parasitology; D017252:CD3 Complex; D002478:Cells, Cultured; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000469:parasitology*; D014349:Trypanosoma cruzi / Q000254:growth & development* / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D000953:Antigens, Protozoan; D017252:CD3 Complex; D006684:HLA-DR Antigens; D011948:Receptors, Antigen, T-Cell
Infection des lymphocytes T par Trypanosoma cruzi. Rôle possible du CD3 et du HLA-DR.