[Cardioprotective properties of a 1,4-dihydropyridine derivative, glutapyrone, in deep hypothermia].
Effect of the derivative of 1,4-dihydropyridine-glutapyron on the activity of Ca2(+)-ATPase, lipid peroxidation and formation of the high-energy phosphate in the myocardium under deep hypothermia was investigated. Analysis of chemiluminescence parameters and changes of malondialdehyde production as a measure of peroxidation has shown high antioxidant activity of glutapyron under deep hypothermia. The inhibition of peroxidation by glutapyron takes place in the lipids of erythrocyte and heart mitochondrial membranes. Due to antioxidant activity glutapyron is able to inhibit initiation of free radical lipid oxidation, to stabilize membrane structure and to preserve function of membrane integrated proteins. In the aggregate these actins promote activity maintenance of high-energy phosphate production and transport reactions in heart under deep hypothermia.
Utno
L Ia
LIa
Lipsberga
Z E
ZE
Silova
A A
AA
Girgensone
M Ia
MIa
Bisenieks
E A
EA
Dubur
G Ia
GIa
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004095:Dihydropyridines / Q000494:pharmacology*; D005609:Free Radicals; D006321:Heart / Q000187:drug effects*; D007036:Hypothermia, Induced; D015227:Lipid Peroxidation; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D004095:Dihydropyridines; D005609:Free Radicals; D000252:Calcium-Transporting ATPases
Kardioprotektornye svoĭstva proizvodnogo 1,4-digidropiridina glutapirona v usloviiakh glubokoĭ gipotermii.