Kinetics of destruction and regeneration of the haemopoietic system after administration of busulphan and cyclophosphamide followed by bone marrow transplantation. Peripheral blood parameters.
The kinetics of restoration of haemopoiesis was studied in 10 patients prepared for allogenic bone marrow transplantation with busulphan combined with cyclophosphamide. The morphology of peripheral blood after administration of these drugs and transplantation of allogenic bone marrow was similar to that reported elsewhere after irradiation, cyclophosphamide administration and bone marrow transplantation, the cell counts falling almost to zero within several days after the end of the pharmacological preparation, and later rising to normal values within the period from several weeks to several months after transplantation.
Szczylik
C
C
Ratajczak
M Z
MZ
Urbanowska
E
E
Jedrzejczak
W W
WW
D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004906:Erythrocyte Count; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D007223:Infant; D007700:Kinetics; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D012156:Reticulocytes
D003520:Cyclophosphamide; D002066:Busulfan