title: Fleroxacin resistance in Escherichia coli.
abstract: Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.
authors.affiliation: Roche Research Center, Nutley, New Jersey 07110.
authors.forename: J S
authors.initials: JS
authors.lastname: Chapman
authors.forename: A
authors.initials: A
authors.lastname: Bertasso
authors.forename: N H
authors.initials: NH
authors.lastname: Georgopapadakou
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000096:biosynthesis; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D016576:Fleroxacin; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D002939:Ciprofloxacin; D004250:DNA Topoisomerases, Type II; D016576:Fleroxacin