Contrasting actions of estradiol on the growth of human gastric cancer xenografts in nude mice.
The effects of estradiol on the growth of six human gastric xenografts in nude mice were studied and diverse effects were found, including one case of stimulation, two of inhibition and three of unchanged condition. Neither the histological features of the original tumor nor the estrogen-binding capacity seemed to be related to the response to estradiol. It is concluded that the growth of human gastric cancer can be modulated by estradiol.
Tokunaga
A
A
First Department of Surgery, Nippon Medical School, Tokyo.
Onda
M
M
Kiyama
T
T
Nishi
K
K
Mizutani
T
T
Yoshiyuki
T
T
Shimizu
Y
Y
Matsukura
N
N
Tanaka
N
N
Asano
G
G
D000818:Animals; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D013629:Tamoxifen / Q000494:pharmacology
D013629:Tamoxifen; D004958:Estradiol