Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man.
Nocturnal plasma melatonin concentrations were reduced following administration of the alpha 1 adrenoceptor antagonist, prazosin (2 mg orally at 1900h), to 10 normal men. These data indicate that alpha 1 adrenoceptors are involved in the physiological control of melatonin secretion in man.
Palazidou
E
E
Institute of Psychiatry, De Crespigny Park, London, U.K.
Franey
C
C
Arendt
J
J
Stahl
S
S
Checkley
S
S
D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D010870:Pineal Gland / Q000187:drug effects / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
D011941:Receptors, Adrenergic; D008550:Melatonin; D011224:Prazosin