[Structure of the correlations of genetic and environmental factors in congenital hip dislocation].
The aim of this paper was to determine the mechanisms of development or manifestations of the congenital dislocation of the hip by the method of multivariate analysis. The source of information were the family data about 300 children with congenital dislocation of the hip aged from 3 months to 15 years who had not been specially selected from those treated at the Centre and 300 children of the same age from unselected population. All the examinees were Georgians by nationality. Clinical methods of examination were employed. The results of the cluster analysis showed that the system of prognostic signs of the congenital dislocation of the hip consisted of 13 clusters in the experimental group (4 independent and 9 correlated) and of 13 clusters in the control group (5 independent and 8 correlated). The signs under investigation comprised the following groups of probable factors of the congenital dislocation of the hip: social-biological, geographical, obstetrical-gynecological, risk factors during the pregnancy, risk factors during the child birth on the mother's part, risk factors on the child's part, perinatal factors, postnatal factors, abnormalities of the child and its relatives. The obtained system of prognosis is well agreed with the biological mechanisms of the congenital dislocation of the hip. These data may be used for making perinatal and preclinical diagnosis, for raising the efficiency of medicogenetic consultations and for the initial orthopaedic prevention of the disease.
Lordkipanidze
E F
EF
Aladashvili
L T
LT
Kakauridze
M V
MV
D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D005260:Female; D005846:Georgia (Republic); D006618:Hip Dislocation, Congenital / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011379:Prognosis; D012307:Risk Factors; D012959:Socioeconomic Factors
Struktura vzaimosviazeĭ geneticheskikh i sredovykh faktorov vrozhdennogo vyvikha bedra.