Vasopressin V1-receptor blockade lowers arterial blood pressure in young conscious Long-Evans rats.
Young, conscious Long-Evans rats had significantly higher basal mean arterial blood pressure than age-matched Brattleboro rats with hereditary hypothalamic diabetes insipidus, and an intravenous injection of a specific vasopressin V1-receptor blocker significantly decreased the mean arterial pressure in the former animals only. The basal heart rate, which was significantly higher in the Brattleboro rats than in the Long-Evans rats, was unaffected by the vasopressin antagonist in either strain. These results indicate that vasopressin may be important in maintaining normal blood pressure in young rats.
Obika
L F
LF
Department of Physiology & Biochemistry, University of Ilorin, Nigeria.
Laycock
J F
JF
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000502:physiology*; D017483:Receptors, Vasopressin; D014667:Vasopressins / Q000502:physiology*
D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D014667:Vasopressins; D001127:Arginine Vasopressin; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-