title: [Possibility of using immunologic indicators in evaluating the effect of pesticides on the body].
abstract: The modern problem of pesticide-related pathogenic body effect has been studied from different points of view. However, some medical aspects of pesticide-induced diseases, primarily their effect on the immune status, remain insufficiently explored. The study is designed to analyze pesticide effect on basic indicators of humoral and cellular immune factors and also to develop a new principle for assessing their exposure according to the degree of immune changes in those exposed to pesticides. Proceeding from the study results it is possible to conclude that under long-term exposure to pesticide microdoses the human body undergoes complex changes: there develops autoimmunization accompanied by the manifestation of antitissue autoantibodies, reduction of serum complement activity, relative content of T-lymphocytes and elevation of the level of B-lymphocytes. Toxicant-related body sensitization and decline in immuno-resistance can serve as the main cause for the deterioration of health status of the residents of the rural areas characterized by higher chemical exposure.
authors.forename: V I
authors.initials: VI
authors.lastname: Krivoruchko
authors.forename: R D
authors.initials: RD
authors.lastname: Dzhabbarov
mesh_terms: D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000276:immunology; D008875:Middle Aged; D014610:Uzbekistan
chemical_list: D001323:Autoantibodies; D007306:Insecticides
vernacular_title: Vozmozhnosti ispol'zovaniia immunologicheskikh pokazateleĭ v otsenke vozdeĭstviia na organizm pestitsidov.