Epitestosterone--an endogenous antiandrogen?
Epitestosterone (17 alpha-hydroxy-4-androsten-3-one), a normal constituent of human plasma and urine, prevents the testosterone induced changes in body weight and in organ weights of seminal vesicles and kidney of castrated male mice. It competes with methyltrienolone in the binding to rat prostate cytosol (Ki = 29.8 nmol.l-1. It inhibits also the activity of 5 alpha-reductase from rat prostate pellet (Ki = 1.2 mumols.l-1). Epitestosterone can be considered as a weak antiandrogen in the term of displacement of androgen from receptor binding and as an efficient inhibitor of 5 alpha-reductase.
Stárka
L
L
Research Institute of Endocrinology, Praha, Czechoslovakia.
Bicíková
M
M
Hampl
R
R
D000818:Animals; D042944:Cholestenone 5 alpha-Reductase; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D003600:Cytosol / Q000378:metabolism; D004845:Epitestosterone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D011467:Prostate / Q000201:enzymology; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism*; D013739:Testosterone / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D011944:Receptors, Androgen; D013739:Testosterone; D004845:Epitestosterone; D017373:Cyproterone Acetate; D003534:Cyproterone; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase