[Nicotinamide correction of the oxidative metabolism of cerebral cortex cells in the kindling phenomenon].
A corrective effect of Nicotinamide on oxidation processes in ganglion and neuroglial cells of cerebral cortex sensorimotor zone in "kindling" phenomenon was studied in the experiments on mice of C57BL line. The kindling was caused by daily injection of Corazol in a dose of 30 micrograms/kg intraperitoneally during one month. The experimental mice were introduced Corazol by the same scheme but beginning from the 4th week Nicotinamide was injected daily/5, 50, 200 mg/kg intraperitoneally/30 min before Corazol introduction. Cytophotometric investigations of enzyme activity/glytamate-, succinate-, -glycerophosphate, glucose-6-phosphate-dehydrogenase and NADH-tetrazol reductase/showed that the most optimum dose of nicotinamide stimulating the tissue oxidation in the dose of 50 mg/kg. It was also established that nicotinamide in the dose of 50 mg/kg has a definite antispasmodic effect and increases ganglion cells stability to destructive effect of epiphogenic factors.
Moiseev
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D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology; D003592:Cytophotometry; D004305:Dose-Response Relationship, Drug; D006651:Histocytochemistry; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009536:Niacinamide / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology
D009536:Niacinamide; D010433:Pentylenetetrazole
Korrektsiia nikotinamidom okislitel'nogo obmena kletok kory golovnogo mozga pri fenomene "raskachki".