title: [Evaluation of the cardiac and peripheral vascular effects of the administration of single-dose enalapril and captopril in essential arterial hypertension].
abstract: The effects of single orally-administered dose of enalapril and captopril on central and district-peripheral circulations have been studied in 20 patients with essential arterial hypertension. Either drug caused a decrease in arterial pressure, telesystolic and telediastolic parietal stress, and a reduction in the peripheral vascular resistance of upper limb district. Furthermore, at the upper limb district level, increases in arterial flow and venous-system capacity have been observed. The entity of these modifications induced by enalapril and captopril appeared comparable, according to the respective peak-time and used dosages. Under this study conditions, the difference between the drugs resulted to be essentially of chronological nature.
authors.forename: C
authors.initials: C
authors.lastname: Longhini
authors.forename: L
authors.initials: L
authors.lastname: Ansani
authors.forename: G F
authors.initials: GF
authors.lastname: Musacci
authors.forename: M
authors.initials: M
authors.lastname: Vaccari
authors.forename: G P
authors.initials: GP
authors.lastname: Fraccaroli
authors.forename: D
authors.initials: D
authors.lastname: Mele
authors.forename: S
authors.initials: S
authors.lastname: Aggio
authors.forename: E
authors.initials: E
authors.lastname: Baracca
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage* / Q000627:therapeutic use; D004452:Echocardiography; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D004656:Enalapril; D002216:Captopril
vernacular_title: Valutazione degli effetti cardiaci e vascolari periferici della somministrazione in dose singola di enalapril e captopril nell'ipertensione arteriosa essenziale.