[Glycosphingolipids affect on the functional properties of human lymphocytes--in relation to HIV-infection of lymphocytes].
Glycosphingolipids, which are functionally present on plasma membrane of mammalian cells, have a variety of functions in immune system such as surface markers of lymphocytes and mediators or modulators of the cells. Interestingly, gangliosides induced selective modulation of CD4, which is not only the subset marker of T-lymphocytes but also the receptor for human immunodeficiency virus. Here, we raised a process of endocytosis as a possible mechanism for the modulation of CD4. We also found that gangliosides inhibited HIV-infection in vitro.
Nakakuma
H
H
Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
Kawaguchi
T
T
Takatsuki
K
K
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology / Q000378:metabolism; D002478:Cells, Cultured; D004705:Endocytosis; D005732:Gangliosides / Q000502:physiology*; D006678:HIV / Q000276:immunology*; D006801:Humans; D011991:Receptors, Virus; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D015704:CD4 Antigens; D005732:Gangliosides; D011991:Receptors, Virus