Synthesis and in vitro effects on platelets and vascular smooth muscle of S-145, a novel thromboxane receptor antagonist.
Narisada
M
M
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Ohtani
M
M
Watanabe
F
F
Uchida
K
K
Arita
H
H
Doteuchi
M
M
Ueda
M
M
Hanasaki
K
K
Kakushi
H
H
Otani
K
K
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D005229:Fatty Acids, Monounsaturated; D007202:Indicators and Reagents; D011982:Receptors, Prostaglandin; C056566:S 145