[The participation of serotonin in regulating cyclic nucleotide levels in early sea urchin embryos].
Abnormal cleavage, decrease in the intracellular cAMP and cGMP content and a trend for increase of extracellular cAMP content were observed in sea urchin embryos incubated with KIuR-14 serotoninolytic substance. The addition of serotonin leads to normalization of cleavage and cAMP and cGMP content. It suggests serotonin-specific effect of KIuR-14 and functional relations between serotonin and cyclic nucleotides.
Sadokova
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D000818:Animals; D002970:Cleavage Stage, Ovum / Q000187:drug effects / Q000378:metabolism; D003404:Creatinine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004338:Drug Combinations / Q000494:pharmacology; D004130:N,N-Dimethyltryptamine / Q000031:analogs & derivatives / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D004338:Drug Combinations; D009712:Nucleotides, Cyclic; D012702:Serotonin Antagonists; C014050:creatinine sulfate, serotonin drug combination; C059677:5-methyl-3-ethyl-2-dimethylaminoethylindole; D012701:Serotonin; D003404:Creatinine; D000242:Cyclic AMP; D006152:Cyclic GMP; D004130:N,N-Dimethyltryptamine
Uchastie serotonina v reguliatsii urovneĭ tsiklicheskikh nukleotidov u rannikh zarodysheĭ morskogo ezha.