title: Stimulation of estrogen receptor mRNA levels in MCF-7 cells by herpes simplex virus infection.
abstract: Infection of estrogen-responsive cells (MCF-7) with herpes simplex virus type 1 or 2 stimulates expression of the estrogen receptor message. Experiments on infection with the mutant virus, tsK, together with transfection studies implicate the virion protein, Vmw65, in the response. Cellular protein synthesis is essential for estrogen receptor mRNA expression.
authors.affiliation: Institute of Virology, University of Glasgow, Scotland.
authors.forename: E A
authors.initials: EA
authors.lastname: Offord
authors.forename: R E
authors.initials: RE
authors.lastname: Leake
authors.forename: J C
authors.initials: JC
authors.lastname: Macnab
mesh_terms: D015152:Blotting, Northern; D001943:Breast Neoplasms / Q000235:genetics; D003513:Cycloheximide / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006561:Herpes Simplex / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics*; D018139:Simplexvirus; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen; D014764:Viral Proteins; D003513:Cycloheximide