title: A comparison of the cerebral hemodynamic effects of sufentanil and isoflurane in humans undergoing carotid endarterectomy.
abstract: Prompted by reports of potentially deleterious cerebral vasodilation by the synthetic opioid sufentanil, the authors compared the effects of either isoflurane/N2O and sufentanil/N2O on cerebral blood flow (CBF), arteriovenous difference in oxygen content (AVDO2), and CBF reactivity to changes in PaCO2 during carotid endarterectomy. Cerebral blood flow was measured using the iv method of 133-Xe CBF determination and AVDO2 was measured using systemic arterial-jugular venous oxygen content differences. Patients, age 68 +/- 1 yr (mean +/- SE), received either isoflurane (n = 10), 0.75% in O2 and N2O, 1:1; or sufentanil (n = 10), 1.5-2 micrograms/kg bolus and then 0.2-0.3 micrograms.kg-1.h-1 infusion in addition to O2 and N2O, 2:3. Measurements were made immediately before carotid occlusion, and then at two levels of PaCO2 (approximately 32 and 42 mmHg) after insertion of a temporary in-dwelling bypass shunt. Prior to carotid occlusion, there was no significant difference in CBF (ml.100 g-1.min-1) between patients receiving isoflurane (22 +/- 3) or sufentanil (20 +/- 2). Similarly, there was no difference in AVDO2 (vol-%) between isoflurane (4.5 +/- 0.7) and sufentanil (5.4 +/- 0.8) groups. Using a two-way ANOVA design with anesthetic as the between-group factor and elevation of PaCO2 as the within-group repeated measure, there was a significant effect of hypercarbia to increase CBF (P less than 0.0001) and decrease AVDO2 (P less than 0.001). The product of AVDO2 and CBF, which reflects cerebral metabolic oxygen consumption, remained constant (P = 0.364).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: W L
authors.initials: WL
authors.lastname: Young
authors.forename: I
authors.initials: I
authors.lastname: Prohovnik
authors.forename: J W
authors.initials: JW
authors.lastname: Correll
authors.forename: N
authors.initials: N
authors.lastname: Ostapkovich
authors.forename: E
authors.initials: E
authors.lastname: Ornstein
authors.forename: R S
authors.initials: RS
authors.lastname: Matteo
authors.forename: K Z
authors.initials: KZ
authors.lastname: Baker
mesh_terms: D000368:Aged; D000777:Anesthetics; D002245:Carbon Dioxide / Q000097:blood; D002339:Carotid Arteries / Q000601:surgery*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004691:Endarterectomy; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives*; D006801:Humans; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D017409:Sufentanil
chemical_list: D000777:Anesthetics; D002245:Carbon Dioxide; D017409:Sufentanil; D007530:Isoflurane; D010100:Oxygen; D005283:Fentanyl