The mouse bone marrow micronucleus test: evaluation of 21 drug candidates.
The mouse bone-marrow micronucleus test is one of the most widely used genetic toxicology assays. In this report the results of testing 21 compounds in the micronucleus test are presented. Of the 21 compounds tested, 3 potential chemotherapeutic agents were identified as strongly clastogenic. In addition, one compound was identified as a weak inducer of micronuclei in the assay. Further testing of this compound in an in vivo bone marrow metaphase analysis failed to confirm this material as clastogenic. The remaining 17 compounds were classified as negative in the assay. In general the results of the micronucleus test agreed with the results of other genetic toxicology assays on this group of compounds.
Aaron
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Upjohn Company, Kalamazoo, MI 49001.
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Zimmer
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D000818:Animals; D000903:Antibiotics, Antineoplastic; D001572:Benzofurans; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D003509:Cyclohexanecarboxylic Acids / Q000633:toxicity; D053138:Cyclohexenes; D000080890:Duocarmycins; D005260:Female; D007211:Indoles; D007555:Isoxazoles / Q000633:toxicity; D008297:Male; D017290:Menogaril; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens; D009621:Nogalamycin / Q000031:analogs & derivatives / Q000633:toxicity; D010879:Piperazines / Q000633:toxicity; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D001572:Benzofurans; D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; D000080890:Duocarmycins; D007211:Indoles; D007555:Isoxazoles; D009153:Mutagens; D010879:Piperazines; C060090:adozelesin; D017290:Menogaril; C036654:losulazine hydrochloride; D009621:Nogalamycin; C006303:acivicin