title: Effect of preclotting on the porosity and thrombogenicity of knitted Dacron grafts.
abstract: The effects of single- and four-stage preclotting methods on graft porosity and thrombogenicity were compared in two types of Dacron prosthesis. The single-stage method significantly reduced leakage of blood (P less than 0.001), but did not seal the grafts. The four-stage method rendered the grafts impermeable at the second step. Thrombogenicity was compared by perfusing preclotted grafts with fresh heparinized blood (containing 111In-labelled platelets) in an artificial circulation. Platelet deposition and consumption were significantly less in the four-stage method whilst platelet function remained unchanged during perfusion. We conclude that the four-stage technique is superior to standard preclotting methods by rendering knitted Dacron grafts impermeable and hypothrombogenic.
authors.affiliation: Cardiac Research Unit, Killingbeck Hospital, Leeds, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Sheehan
authors.forename: S M
authors.initials: SM
authors.lastname: Rajah
authors.forename: R C
authors.initials: RC
authors.lastname: Kester
mesh_terms: D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates; D013927:Thrombosis / Q000517:prevention & control; D013997:Time Factors; D014654:Vascular Patency; D014914:Whole Blood Coagulation Time
chemical_list: D011093:Polyethylene Terephthalates