Generalized cutaneous hyperpigmentation in hairless mice induced by topical dimethylbenzanthracene.
The skin of hairless (Ng/Bln) mice topically treated with dimethylbenzanthracene (DMBA) was investigated by light microscopy, histochemistry, electron microscopy and autoradiography in order to gain some insight into the mechanisms by which the DMBA-induced cutaneous hyperpigmentation is mediated. The results of the present study indicate that this phenomenon is due to the DMBA-induced stimulation of both the tyrosinase system and the mitotic activity of dopa-inactive dormant melanocytes.
Tsambaos
D
D
Department of Dermatology, University of Patras, Greece.
Sampalis
F
F
Berger
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001345:Autoradiography; D005260:Female; D015603:Keratinocytes / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis; D008544:Melanocytes / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D051379:Mice; D008812:Mice, Hairless; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure
D008543:Melanins; D015127:9,10-Dimethyl-1,2-benzanthracene