Chronic nicotine use blocks haloperidol-induced increase in striatal D2-dopamine receptor density.
Epidemiologic studies have suggested a positive association in man between nicotine use and the incidence of tardive dyskinesia, a disease characterized by dopaminergic supersensitivity after chronic neuroleptic therapy. In rats, repeated administration of neuroleptics results into dopaminergic supersensitivity and increased density of striatal D2-dopamine receptors. We investigated the effects of 6-week continuous nicotine intake on the neuroleptic (haloperidol)-induced increase in murine striatal D2-dopamine receptor density. Contrary to expectations, our data show that nicotine blocked the increase in D2-dopamine receptor density after neuroleptic administration.
Prasad
C
C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Spahn
S A
SA
Ikegami
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004409:Dyskinesia, Drug-Induced; D004435:Eating / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D009538:Nicotine; D006220:Haloperidol