Regional brain distribution of [18F]GBR 13119, a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice.
We have examined the regional brain distribution of [18F]GBR 13119 (18F: beta +, T1/2 = 110 min), a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice. High levels of binding are observed in the striatum of both species, with striatum/cerebellum ratios of 3-4 at 60 min after injection of the radiotracer. Striatum radioactivity and striatum/cerebellum ratios are more than 50% reduced in C57BL/6 mice treated chronically with the neurotoxin MPTP. We conclude mice are an appropriate model for the in vivo study of the dopamine uptake system, and that [18F]GBR 13119 may be a suitable in vivo marker for degeneration of striatal dopaminergic neurons.
Kilbourn
M R
MR
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109.
Haka
M S
MS
Mulholland
G K
GK
Sherman
P S
PS
Pisani
T
T
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D014179:Neurotransmitter Uptake Inhibitors / Q000493:pharmacokinetics*; D010879:Piperazines / Q000493:pharmacokinetics*
D014179:Neurotransmitter Uptake Inhibitors; D010879:Piperazines; C055278:GBR 13119; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine