[Contact hypersensitivity (DNCB test) and inhibition by the calcium channel blocker diltiazem].
We studied the influence of the calcium transport inhibitor diltiazem on epidermal Langerhans cell-induced contact dermatitis against 1-chloro-2.4-dinitrobenzene (DNCB) in Balb/c mice. Diltiazem administered systemically was found to be able to decrease allergic reactions against DNCB. Twenty four hours post challenge animals treated with diltiazem demonstrated a 36% decreased ear swelling compared with non diltiazem-treated animals (p less than 0.001). From these results, we conclude that calcium is important in regulating epidermal Langerhans cell functions and in activating these cells.
Diezel
W
W
Gruner
S
S
Anhalt
G J
GJ
Strunk
D
D
Shanks
M
M
Sönnichsen
N
N
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects*; D003877:Dermatitis, Contact / Q000276:immunology*; D004110:Diltiazem / Q000494:pharmacology*; D004137:Dinitrochlorobenzene / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin / Q000276:immunology
D015220:Calcium Channels; D004137:Dinitrochlorobenzene; D004110:Diltiazem; D002118:Calcium
Kontaktüberempfindlichkeit (DNCB-Test) und Hemmung durch den Calcium-Kanal-Blocker Diltiazem.