title: Mutagenicity arising from boiled rice on treatment with nitrous acid.
abstract: When an aqueous homogenate of boiled rice was treated with nitrous acid at pH 3, direct-acting mutagens were formed. The presence of the mutagens was demonstrated by isolating the mutagenic fractions through blue-rayon adsorption, a method used to extract polycyclic compounds, and subsequent high-performance liquid chromatography (HPLC). The mutagens were active in Salmonella typhimurium TA100 and TA98 without metabolic activation. Several different mutagens were formed, as judged from the HPLC profile.
authors.affiliation: Faculty of Pharmaceutical Sciences, Okayama University.
authors.forename: H
authors.initials: H
authors.lastname: Hayatsu
authors.forename: T
authors.initials: T
authors.lastname: Hayatsu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D009608:Nitrous Acid / Q000378:metabolism*; D012275:Oryza
chemical_list: D009153:Mutagens; D009573:Nitrites; D009608:Nitrous Acid