title: Comparative pathogenesis of serotype 1 and variant serotype 1 isolates of infectious bursal disease virus and their effect on humoral and cellular immune competence of specific-pathogen-free chickens.
abstract: Specific-pathogen-free chickens inoculated with isolate VA (variant A) or isolate IM of infectious bursal disease virus (IBDV) were examined for mitogenic response to T-cell mitogens, primary and secondary antibody response to sheep erythrocytes and Brucella abortus, and gross and histologic lesions in thymus and bursa. Both isolates induced comparable depression in the mitogenic and antibody response, and both caused extensive gross and histologic lesions in the bursa of Fabricius. However, bursal necrosis induced by the IM isolate was accompanied by an inflammatory response, whereas the inflammatory component was lacking in the lesion induced by the VA isolate. Furthermore, the IM isolate induced extensive lesions in the thymus, but the VA isolate did not.
authors.affiliation: U.S. Department of Agriculture, Regional Poultry Research Laboratory, East Lansing, Michigan 48823.
authors.forename: J M
authors.initials: JM
authors.lastname: Sharma
authors.forename: J E
authors.initials: JE
authors.lastname: Dohms
authors.forename: A L
authors.initials: AL
authors.lastname: Metz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D004797:Enzyme-Linked Immunosorbent Assay; D007111:Immunity, Cellular; D007243:Infectious bursal disease virus / Q000276:immunology* / Q000472:pathogenicity; D008213:Lymphocyte Activation; D011201:Poultry Diseases / Q000276:immunology* / Q000473:pathology; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000473:pathology
chemical_list: D000914:Antibodies, Viral