[The 75-seleno-homocholic acid-taurine test (SeHCAT). A useful method for detecting the idiopathic malabsorption of bile salts in chronic functional diarrhea].
The 75-SeHCAT test has been used for identifying, within a group of patients with chronic functional diarrhea, a subgroup of cases with ileal bile acid malabsorption. Thirty-four subjects were studied: 10 healthy subjects and 24 patients with chronic functional diarrhea. Findings are expressed as percentage of basal abdominal radioactivity after 7 days. Normal values in our control subjects were: over 25% on day 4 and over 10% on day 7. Pathological results were found in 9 of 24 patients (37.5%) on day 4 and of 24 patients (41.7%) on day 7. A significant correlation was found between the percentages of retention on days 4 and 7 (p less than 0.001). In SeHCAT-positive patients cholestyramine administration led to clinical improvement. According to our experience, the SeHCAT test is a useful tool for the evaluation of bile acid malabsorption in the differential diagnosis of chronic functional diarrhea.
D'Arienzo
A
A
Maurelli
L
L
Di Siervi
P
P
Panarese
A
A
Giannattasio
F
F
Scuotto
A
A
Squame
G
G
Mazzacca
G
G
D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives*
D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid
Il test al 75-selenio-omotauroglicolato (SeHCAT). Un utile metodo per rilevare il malassorbimento idiopatico di sali biliari nella diarrea cronica funzionale.