title: Modulation by neurotransmitters (norepinephrine, serotonin) of the murine antibody response to autologous and heterologous erythrocytes.
abstract: The modulation by norepinephrine and serotonin of the persistent antibody response to autologous and heterologous erythrocytes has been studied in [(C27Bl6xCBA/Ca) F1] mice. Serotonin (subcutaneously administered) transiently decreased the response to both autologous erythrocytes and rat erythrocytes; nevertheless, inhibition of serotonin synthesis (with p-chloro-phenylalanine) barely affected the responses. The influence of norepinephrine has been investigated by (subcutaneous) administration of ephedrine (a sympathomimetic) or by neonatal sympathectomy with 6-hydroxydopamine. Neither the sympathomimetic nor the sympathectomy substantially altered the response (of adult mice) to autologous or heterologous erythrocytes. Treatment with p-chloro-phenylalanine of adult mice (which had been neonatally treated with 6-hydroxydopamine) resulted in impaired responses to both autologous and heterologous erythrocytes. On the whole, a fall in the level of norepinephrine or serotonin exerted, at most, a minor influence on the persistent antibody response to self and foreign erythrocytes, but a decrease of both amines exerted a greater influence.
authors.affiliation: Instituto Municipal de Investigatión Médica, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vidal
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013562:Sympathectomy
chemical_list: D001323:Autoantibodies; D012701:Serotonin; D010134:Fenclonine; D009638:Norepinephrine