[A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC].
A 68-year-old male, who had advanced rectal cancer with multiple pulmonary metastases, had undergone resection of rectal cancer operatively and was treated with a combination chemotherapy using 5'-DFUR (5'-deoxy-5-fluorouridine) and MMC (mitomycin C) for multiple pulmonary metastases. Nine months from the start of this therapy, pulmonary metastatic lesions disappeared completely on chest X-ray examination and computed tomography. This case corresponded to complete response (CR) according to the response criteria proposed by Koyama-Saitoh. No significant side effects were observed during this chemotherapy. From the results in this case, the combination chemotherapy was considered to be one of the effective antineoplastic therapies available for pulmonary metastasis from large bowel cancer.
Matsuda
M
M
Dept. of Surgery (Coloproctology), Kumamoto Municipal Hospital.
Nagao
K
K
Baba
K
K
Nishimura
R
R
Matsuoka
Y
Y
Ueno
Y
Y
Morinaga
H
H
Nagase
H
H
Kawano
H
H
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004361:Drug Tolerance; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000473:pathology*; D012074:Remission Induction
D008937:Mitomycins; D005467:Floxuridine; D016685:Mitomycin; C025034:doxifluridine