Treatment with GM1 ganglioside reverses dopamine D-2 receptor supersensitivity induced by the neurotoxin MPTP.
Treatment of mice with the neurotoxin MPTP to destroy nigrostriatal dopaminergic neurons results in up-regulation of D-2 receptors in the striatum when studied after 30 days. Administration of GM1 ganglioside after inducing the lesion prevents D-2 receptor up-regulation. The ganglioside has no apparent effect when administered to normal animals.
Hadjiconstantinou
M
M
Department of Pharmacology, Ohio State University, Columbus 43210.
Weihmuller
F
F
Neff
N H
NH
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D009498:Neurotoxins / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D014316:Tritium
D009498:Neurotoxins; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D014316:Tritium; D005677:G(M1) Ganglioside; D013134:Spiperone; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine