Peripheral T cells in diabetes prone (DP) BB rats are CD45R-negative.
Diabetes prone BB (DP BB) rats are known to develop insulin dependent diabetes mellitus. In addition, a number of other immune abnormalities have been observed, like severe T lymphopenia, lack of CD8+ T cells, and lack of RT6+ T cells. Here we report double-labelling studies of lymph node T cells using MRC OX-32 (CD45R), and demonstrate that this T cell subset is absent in young adult DP BB rats. Since both RT6 and MRC OX-32 antigens are only expressed by mature peripheral T cells, it is tempting to speculate that the peripheral T cell pool of DP BB rats consists only of immature peripheral T cells, i.e. recent thymic emigrants.
Groen
H
H
Department of Histology and Cell Biology, University of Groningen, The Netherlands.
van der Berk
J M
JM
Nieuwenhuis
P
P
Kampinga
J
J
D000818:Animals; D015703:Antigens, CD / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis; D017493:Leukocyte Common Antigens; D008297:Male; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D051381:Rats; D011913:Rats, Inbred BB; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D015704:CD4 Antigens; D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat; D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1