title: [Neurotoxicity in long-term lithium therapy: an electroneurographic study].
abstract: In a series of 16 patients on long-term lithium therapy pathological changes were found in peripheral nerve conduction. Such changes correlated with the duration of lithium therapy (mean: 8.3 years, range: 3-15 years; p less than 0.05). No patient showed clinical signs of polyneuropathy or any other disease known to be frequently associated with peripheral nerve lesions. Compared with an age-matched normal control group (n = 27) the nerve conduction velocity of the sural nerve was reduced (p less than 0.05), for which a chronic neurotoxic effect is considered to be the most probable mechanism.
authors.affiliation: Neurologische Abteilung, NO Landeskrankenhaus Klosterneuburg.
authors.forename: A
authors.initials: A
authors.lastname: Eisenstädter
authors.forename: A
authors.initials: A
authors.lastname: Seiser
authors.forename: M
authors.initials: M
authors.lastname: Brainin
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D016651:Lithium Carbonate; D008134:Long-Term Care; D008297:Male; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D010525:Peripheral Nerves / Q000187:drug effects*; D010543:Peroneal Nerve / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D016651:Lithium Carbonate; D008094:Lithium
vernacular_title: Neurotoxizität bei Langzeit-Lithiumtherapie: eine elektroneurographische Studie.