title: Effects of thyroid status on atrial natriuretic peptide release from isolated rat atria.
abstract: The effect of thyroid hormone on circulating levels of atrial natriuretic peptide (ANP) was studied in experimental hyperthyroid and hypothyroid rats. Plasma ANP was 102 +/- 5 pg/ml in euthyroid rats, 82 +/- 4 pg/ml in hypothyroid rats, and 138 +/- 11 pg/ml in hyperthyroid rats. We have also measured immunoreactive ANP in the atria of euthyroid, hypothyroid, and hyperthyroid rats. ANP content and concentration in the atria were lower (546 +/- 32 pg/mg tissue) in hyperthyroid rats than in hypothyroid rats (802 +/- 74 pg/mg tissue). Right atrium from euthyroid, hypothyroid, and hyperthyroid rats was superfused with a modified Langendorff preparation. Spontaneous release of ANP was significantly higher from the hyperthyroid rats (20 +/- 2 pg.min-1.mg-1) than from the hypothyroid rats (5.6 +/- 0.5 pg.min-1.mg-1). ANP release from the euthyroid rats was 9.3 +/- 1.2 pg.min-1.mg-1. These results indicate hyperthyroidism causes an increase in ANP secretion and a decreased release occurs during hypothyroidism.
authors.affiliation: Department of Medicine, Health Sciences Centre Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: N L
authors.initials: NL
authors.lastname: Wong
authors.forename: D
authors.initials: D
authors.lastname: Huang
authors.forename: N S
authors.initials: NS
authors.lastname: Guo
authors.forename: E F
authors.initials: EF
authors.lastname: Wong
authors.forename: D C
authors.initials: DC
authors.lastname: Hu
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D006325:Heart Atria / Q000378:metabolism; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008713:Methimazole; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine
chemical_list: D008713:Methimazole; D009320:Atrial Natriuretic Factor; D013974:Thyroxine