Selective increase in placental blood flow by atrial natriuretic peptide in hypertensive rats.
Effects of atrial natriuretic peptide on systemic, renal, uterine, and placental hemodynamics were determined in 16-day pregnant normotensive and hypertensive rats and in 20-day pregnant normotensive rats under pentobarbital anesthesia. Relative to 16-day pregnant normotensive rats, the total peripheral resistance was higher in 16-day pregnant hypertensive and 20-day pregnant normotensive rats; atrial natriuretic peptide significantly (p less than 0.05) decreased the total peripheral resistance in the latter two groups of animals. Atrial natriuretic peptide increased the placental blood flow in each of the three groups of animals without significantly affecting renal blood flow. This selective increase in placental blood flow normalized placental hemodynamics in hypertensive rats.
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Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Potvin
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Varma
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D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D009320:Atrial Natriuretic Factor