Influence of thermal stress and various agents on the brain edema formation in rats following a cryogenic brain lesion.
The influence of cold stress, heat stress, or various agents on the development of brain edema were assessed in rats following a cryogenic brain lesion. Brain edema was induced by local cold injury to the cortex. Cerebral edema was assessed 0.5, 3.0 or 24 h after a cryogenic brain lesion by measuring the water content of two hemispheres. Pretreatment of animals with sodium pentobarbital (15 or 30 mg/kg, i.p.) or lidocaine (15 mg/kg, i.p.) did not influence the development of brain edema. In addition, pretreatment with an external heat stress (heat exposure of 32 degrees C for 6 h) exaggerated significantly the development of brain edema in the rat following a cryogenic brain lesion. On the other hand, pretreatment of animals with either external cold stress (cold exposure of 8 degrees C for 6 h), glycerol (10% 10 ml, i.p.), mannitol (15% 10 ml, i.p.), gamma-hydroxybutyric acid (300 mg/kg, i.p.), metiamide (5 mg/kg, i.p.), dexamethasone (4 mg/kg, i.p.), aminophylline (100 mg/kg, i.p.), or ketamine (30 mg/kg, i.p.) inhibited significantly the brain edema formation.
Lin
L S
LS
Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
Chiu
W T
WT
Shih
C J
CJ
Lin
M T
MT
D000818:Animals; D001834:Body Water / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000517:prevention & control; D001930:Brain Injuries / Q000150:complications; D003080:Cold Temperature; D005990:Glycerol / Q000494:pharmacology; D006358:Hot Temperature / Q000009:adverse effects; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications
D008353:Mannitol; D007649:Ketamine; D005990:Glycerol