[Effect of cigarette-smoke tar on oxygenation activity of granulocytes detected by luminol- and lucigenin-enhanced chemiluminescence response of rabbit whole blood].
Both luminol- and lucigenin-dependent rabbit whole blood chemiluminescence showed a concentration-dependent inhibition response to cigarette-smoke tar of 0.26 to 2.6 mg/ml. Tar showed no cytotoxicity to granulocytes by Evans blue exclusion. It is suggested that oxygenation activity of granulocytes in smoker's blood could be depressed by tar, resulting in harmful effects on the host defense mechanism with increase of susceptibility to infection and incidence of tumorigenicity.
Zhang
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D000166:Acridines / Q000494:pharmacology; D000818:Animals; D006098:Granulocytes / Q000378:metabolism*; D008163:Luminescent Measurements; D009374:Neoplasms, Experimental / Q000209:etiology; D010100:Oxygen / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010947:Plants, Toxic; D011817:Rabbits; D012906:Smoke / Q000009:adverse effects*; D013638:Tars / Q000009:adverse effects*; D014026:Nicotiana
D000166:Acridines; D012906:Smoke; D013638:Tars; C033472:10,10'-dimethyl-9,9'-biacridinium; D010100:Oxygen; D010634:Phenobarbital