title: Acitretin monotherapy in Darier's disease.
abstract: The dose response relationship to acitretin in five patients with Darier's disease was investigated. The patients received in the first 3 months 35 mg daily, and the dose was adjusted according to the clinical response. Four of the five patients showed a marked improvement with up to total clearance, although in two patients isomorphic reactions due to a relative overdose were seen. These isomorphic reactions improved with a reduction of dose. We suggest that treatment with acitretin is initiated at 10-25 mg daily with gradual adjustment of the dose.
authors.affiliation: Department of Dermatology, University of Nijmegen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: van Dooren-Greebe
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: R
authors.initials: R
authors.lastname: Happle
mesh_terms: D017255:Acitretin; D000328:Adult; D007644:Darier Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014212:Tretinoin; D017255:Acitretin