title: [Monotherapy, empirical and targetted, with imipenem-cilastatin in sepsis of bacterial origin].
abstract: The authors describe an open study in 22 patients with febrile conditions of unknown origin who were treated with imipenem-cilastatin while waiting for routine laboratory and culture tests. These were done immediately at the patients' entry into hospital, after which imipenem-cilastatin treatment was started immediately, and was subsequently confirmed by the isolates and culture tests. The drug was found to be active and to eradicate the responsible organism in all cases. In addition, it was found to be easy to handle and not to give rise to side-effects or changes in laboratory tests.
authors.forename: F
authors.initials: F
authors.lastname: Fiorentino
authors.forename: R
authors.initials: R
authors.lastname: De Sena
authors.forename: E
authors.initials: E
authors.lastname: Manzillo
authors.forename: A
authors.initials: A
authors.lastname: Iadanza
authors.forename: M
authors.initials: M
authors.lastname: Conte
authors.forename: M G
authors.initials: MG
authors.lastname: Coppola
authors.forename: P
authors.initials: P
authors.lastname: Galderisi
authors.forename: A
authors.initials: A
authors.lastname: Postiglione
authors.forename: M T
authors.initials: MT
authors.lastname: Arciello
authors.forename: B
authors.initials: B
authors.lastname: Covelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D015377:Cilastatin / Q000627:therapeutic use*; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D005335:Fever of Unknown Origin / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination
vernacular_title: La monoterapia, empirica e mirata, con imipenem-cilastatina nelle sepsi ad eziologia batterica.