Recovery of MAO-B enzyme activity after (-)deprenyl (selegiline) pretreatment, measured in vivo.
The recovery of MAO-B activity after a single dose of 0.25 mg/kg s.c. (-)deprenyl was measured in rat, by following the time course of the changes in the PEA (phenyl-ethylamine)-induced hyperactivity. One hour after its administration (-)deprenyl enhanced both the PEA-induced locomotion and stereotypy, however, its effect on the latter was more marked. At 24 h and at later time-points only stereotype was enhanced. The results show that a single small dose of (-)deprenyl which selectively blocks MAO-B, causes a long-lasting inhibition of PEA metabolism, and the enzyme activity needs more than one week to restore completely.
Timár
J
J
Semmelweis University Medical School, Department of Pharmacology Budapest, Hungary.
D000704:Analysis of Variance; D000818:Animals; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D010627:Phenethylamines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D010627:Phenethylamines; D012642:Selegiline; C029261:phenethylamine; D008995:Monoamine Oxidase