Ranitidine maintenance treatment of non-steroidal anti-inflammatory drug-induced duodenal ulceration.
Fifty-six patients who presented with non-steroidal anti-inflammatory drug-associated duodenal ulcers received maintenance treatment with ranitidine. Forty-eight of these patients stopped treatment with non-steroidal anti-inflammatory drugs. The cumulative symptomatic remission at the end of 5 years of maintenance treatment was 97.7%. While half the patients had presented with haemorrhage from the ulcer, only one patient bled during maintenance treatment, giving a cumulative risk of 2.3% in 5 years of maintenance treatment. We conclude that maintenance treatment with ranitidine effectively and safely keeps patients with non-steroidal anti-inflammatory drug-associated ulcers symptom- and risk-free.
Penston
J G
JG
Ninewells Hospital and Medical School, Dundee, Scotland.
Wormsley
K G
KG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D002648:Child; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011899:Ranitidine; D001241:Aspirin