Interleukin 1-like activity in cystic lesions of the jaw.
Odontogenic cyst capsules were cultured in vitro and the culture media analysed for bone-resorption and interleukin 1-like activity. Five cysts synthesised a non-dialysable bone resorbing factor with significant interleukin 1-like activity. One specimen thought to be a cyst with little interleukin 1 activity proved to be antral lining. The results indicate that interleukin 1 may play an important role in cyst expansion by its direct effects on fibroblast proliferation and bone resorption and by stimulating prostaglandin synthesis in stromal fibroblasts of the cyst capsule.
Meghji
S
S
Joint Department of Oral and Maxillofacial Surgery, Institute of Dental Surgery, London.
Harvey
W
W
Harris
M
M
D000328:Adult; D001685:Biological Factors / Q000032:analysis*; D046508:Culture Techniques; D016207:Cytokines; D015232:Dinoprostone / Q000096:biosynthesis; D005347:Fibroblasts / Q000378:metabolism; D005497:Follicular Cyst / Q000032:analysis*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008213:Lymphocyte Activation; D003012:Microbial Collagenase / Q000096:biosynthesis; D010006:Osteoblasts / Q000378:metabolism; D011842:Radicular Cyst / Q000032:analysis*; D013601:T-Lymphocytes / Q000166:cytology
D001685:Biological Factors; D016207:Cytokines; D007375:Interleukin-1; C025940:bone resorption factor; D003012:Microbial Collagenase; D015232:Dinoprostone