Selective neurotoxicity of clioquinol on the function of the posterior column nuclei.
In the gracile nucleus of clioquinol-treated rats, the presynaptic inhibition was remarkably diminished, and the excitatory synaptic transmission was less intensely inhibited by a conditioning sural nerve volley. These changes may be the pathophysiology responsible for paresthesia and/or dysesthesia in patients with subacute optico-myelo-neuropathy (SMON).
Arasaki
K
K
Department of Neurology, University of Tsukuba, Japan.
Nakanishi
T
T
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D007464:Clioquinol / Q000633:toxicity*; D006912:Hydroxyquinolines / Q000633:toxicity*; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology*
D006912:Hydroxyquinolines; D007464:Clioquinol