title: [Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells].
abstract: Activation of the respiratory metabolic channel (F.O.R.), responsible in part for the bactericidal effect, was measured in vitro by a chemoluminescence test on circulating phagocytes. All mycobacteria tested, except for Mycobacterium leprae, induced a significant response. Its effect on lepromatous leprosy pathology is a subject for discussion.
authors.affiliation: Laboratoire d'Immunologie cellulaire, Institut Pasteur de Dakar.
authors.forename: P
authors.initials: P
authors.lastname: Launois
authors.forename: A
authors.initials: A
authors.lastname: Dieye
authors.forename: L
authors.initials: L
authors.lastname: Blum
authors.forename: J
authors.initials: J
authors.lastname: Millan
authors.forename: J L
authors.initials: JL
authors.lastname: Sarthou
mesh_terms: D005609:Free Radicals; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D008163:Luminescent Measurements; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism; D009161:Mycobacterium / Q000502:physiology; D009166:Mycobacterium leprae / Q000502:physiology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D007371:Interferon-gamma; D010100:Oxygen
vernacular_title: Activation macrophagique et Mycobacterium leprae: action de l'interféron gamma sur la production de radicaux oxygénés libres (R.O.L.) des cellules phagocytaires.