Eosinophil levels in the acute phase of experimental Chagas' disease.
Eosinophil dynamics, in bone marrow, blood and peritoneal exudate, of resistant C57B1/6 (C57) and susceptible A/Snell (A/Sn) mice was comparatively studied during the acute phase of infection by Trypanosoma cruzi Y strain. A decline was observed in bone marrow eosinophil levels in A/Sn, but not in C57 mice, soon after infection, those of the former remaining significantly below those of the latter up to the 4th day of infection. Bone marrow eosinophil levels of C57 mice declined subsequently to levels comparable to those of A/Sn mice, the number of these cells in this compartment remaining 50% those of non infected controls, in both strains, up to the end of the experiment on the 14th day of infection. The fluctuations in eosinophil levels in blood and peritoneal space were similar in both mice strains studied. Concomitantly with depletion of eosinophils in the marrow, depletion in blood and a marked rise of these cells in the peritoneal space. initial site of infection, occurred in both strains. The difference in eosinophil bone marrow levels, between C57 and A/Sn mice, observed in the first four days of infection, suggests a higher eosinopoiesis capacity of the former in this period, which might contribute to their higher resistance to T. cruzi infection.
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D000208:Acute Disease; D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D014355:Chagas Disease / Q000469:parasitology / Q000473:pathology*; D004804:Eosinophils; D005260:Female; D007958:Leukocyte Count; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D014349:Trypanosoma cruzi / Q000472:pathogenicity; D014774:Virulence