title: Native interleukin 1 inhibitors.
abstract: Much information has accumulated on the isolation and characterization of a heterogeneous group of molecules that inhibit one or more of the bioactivities of interleukin 1. In this review James Larrick discusses the biological and biochemical data available on several of these native interleukin 1 inhibitors, some of which have additional, unexpected activities.
authors.forename: J W
authors.initials: JW
authors.lastname: Larrick
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005246:Feedback; D005786:Gene Expression Regulation; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000502:physiology; D008264:Macrophages / Q000032:analysis; D051379:Mice; D009088:Mucoproteins / Q000494:pharmacology; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000378:metabolism; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D015398:Signal Transduction; D015291:Transforming Growth Factors / Q000494:pharmacology; D014556:Urine / Q000032:analysis; D058949:Uromodulin; D014777:Virus Diseases / Q000378:metabolism
chemical_list: C507763:IL1RN protein, human; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D009088:Mucoproteins; D011506:Proteins; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; C548612:UMOD protein, human; C548613:Umod protein, mouse; D058949:Uromodulin; D015291:Transforming Growth Factors