title: Behind the Fos and Jun leucine zipper.
abstract: The production of the nuclear oncoproteins Fos and Jun is rapidly induced in response to extracellular signals. In the nucleus, the two proteins combine to form a tight complex via leucine zipper domains. The resulting Fos-Jun heterodimer can bind to the TPA-responsive element (TRE) by way of a novel, highly basic motif and can activate the transcription of TPA-responsive genes. The existence of several Fos- and Jun-related proteins with dimerization and DNA binding properties similar to Fos and Jun suggests that these two oncoproteins may be part of a network of related but functionally distinct transcription factors.
authors.affiliation: Department of Biochemistry, Kaplan Cancer Center, N.Y. University Medical Center, New York 10016.
authors.forename: T
authors.initials: T
authors.lastname: Kouzarides
authors.forename: E
authors.initials: E
authors.lastname: Ziff
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D016759:Oncogene Protein p65(gag-jun); D016761:Oncogene Proteins v-fos; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D016759:Oncogene Protein p65(gag-jun); D016761:Oncogene Proteins v-fos; D009856:Oncogene Proteins, Viral; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors; D004247:DNA; D007930:Leucine