title: Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation.
abstract: This report describes five patients who had immediate adverse reactions following placement of a vascular graft. All had unusually persistent decreases in systemic vascular resistance, and four of these patients had bleeding as an early manifestation of this reaction. In two of three patients in whom the graft was replaced, uneventful recovery followed. Both patients in whom the graft was not replaced died. Blood samples from two of the patients demonstrated activation of complement and of the kinin system, whereas control patients did not demonstrate increased levels of activation products from these cascade systems. Recognition of this syndrome is important to patient survival, which appears to depend on rapid replacement of the graft.
authors.affiliation: Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637.
authors.forename: M F
authors.initials: MF
authors.lastname: Roizen
authors.forename: G M
authors.initials: GM
authors.lastname: Rodgers
authors.forename: F H
authors.initials: FH
authors.lastname: Valone
authors.forename: G H
authors.initials: GH
authors.lastname: Lampe
authors.forename: D J
authors.initials: DJ
authors.lastname: Benefiel
authors.forename: S
authors.initials: S
authors.lastname: Gelman
authors.forename: J
authors.initials: J
authors.lastname: Rapp
authors.forename: J M
authors.initials: JM
authors.lastname: Weiler
authors.forename: M
authors.initials: M
authors.lastname: Ota
authors.forename: M A
authors.initials: MA
authors.lastname: Shuman
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001011:Aorta / Q000601:surgery; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D003167:Complement Activation; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006087:Graft vs Host Reaction; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000276:immunology / Q000473:pathology; D007431:Intraoperative Complications / Q000097:blood / Q000209:etiology* / Q000473:pathology; D007610:Kallikreins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D013997:Time Factors; D014664:Vasodilation
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D011093:Polyethylene Terephthalates; D007610:Kallikreins