Results of a United States and Soviet Union joint project on nervous system effects of microwave radiation.
During the course of a formal program of cooperation between the United States and the Soviet Union concerning the biological effects of physical factors in the environment, it was concluded that duplicate projects should be initiated with the general goal of determining the most sensitive and valid test procedures for evaluating the effects of microwave radiation on the central nervous system. This report details an initial step in this direction. Male rats of the Fischer 344 strain were exposed or sham exposed to 10 mW/cm2 continuous wave microwave radiation at 2.45 GHz for a period of 7 hr. Animals were subjected to behavioral, biochemical, or electrophysiological measurements during and/or immediately after exposure. Behavioral tests used were passive avoidance and activity in an open field. Biochemical measurements were ATPase (Na+, K+; Mg2+, Ca2+) and K+ alkaline phosphatase activities. Electrophysiological measurements consisted of EEG frequency analysis. Neither group observed a significant effect of microwave irradiation on open field activity. Both groups observed changes in variability of the data obtained using the passive avoidance procedure, but not in the same parameters. The U.S. group, but not the USSR group, found significantly less Na+,K+-ATPase activity in the microwave-exposed animals compared to the sham exposed animals. Both groups found incidences of statistically significant effects in the power spectral analysis of EEG frequency, but not at the same frequency. The failure of both groups to substantiate the results of the other reinforces our contention that such duplicate projects are important and necessary.
Mitchell
C L
CL
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
McRee
D I
DI
Peterson
N J
NJ
Tilson
H A
HA
Shandala
M G
MG
Rudnev
M I
MI
Varetskii
V V
VV
Navakatikyan
M I
MI
D000251:Adenosine Triphosphatases / Q000528:radiation effects; D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects; D001921:Brain / Q000201:enzymology / Q000528:radiation effects*; D004569:Electroencephalography; D007391:International Cooperation; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D051381:Rats; D011916:Rats, Inbred F344; D014586:USSR; D014481:United States
D000251:Adenosine Triphosphatases