Influence of trace metals on serum total sialic acids and perchloric acid--soluble proteins and sialic acids in mice.
Male Swiss mice were exposed to a single LD50 (75%; i.p.) of mercury, zinc, lead and manganese to determine their influence on serum sialic acid and protein levels after a refractory period of 48 h. They significantly elevated, in different proportions, the serum levels of total and perchloric acid (PCA)-soluble sialic acids (biological marker) and PCA-soluble proteins, thus indicating their toxicity.
Patel
A B
AB
Department of Neurobehavioural Toxicology, National Institute of Occupational Health (ICMR), Gujarat, India.
Venkatakrishna-Bhatt
H
H
D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D007854:Lead / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D020149:Manganese Poisoning; D008628:Mercury / Q000633:toxicity; D051379:Mice; D019158:N-Acetylneuraminic Acid; D010472:Perchlorates; D012794:Sialic Acids / Q000097:blood*; D013997:Time Factors; D014131:Trace Elements / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity
D001798:Blood Proteins; D010472:Perchlorates; D012794:Sialic Acids; D014131:Trace Elements; D007854:Lead; D008628:Mercury; D019158:N-Acetylneuraminic Acid; D015032:Zinc