Noble PRST-1 Ca prostate adenocarcinoma study on noble rats: preliminary study on new androgen sensitive tumor.
The Nb rat prostatic adenocarcinoma model has served as an animal model for testing various chemotherapeutic agents. Herein this preliminary report, the tumor Nb PRST-1 Ca was evaluated in 25 animals with testosterone, dihydrotestosterone, orchiectomized and control treatments. Tumor growth curves were determined and show a significant difference on day 13 (T-test) between the control group and treatment groups. Metastases were found in the lungs of all animals and a remarkable rounding of the liver was noted in the androgen treatment groups.
Wientjes
G
G
Department of Surgery, College of Medicine, Ohio State University Columbus.
Smith
J
J
Miller
R
R
Badalament
R A
RA
Drago
J R
JR
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D013196:Dihydrotestosterone / Q000627:therapeutic use*; D008297:Male; D009362:Neoplasm Metastasis; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000627:therapeutic use*
D013196:Dihydrotestosterone; D013739:Testosterone