Designing CD4 immunoadhesins for AIDS therapy.
A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.
Capon
D J
DJ
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
Chamow
S M
SM
Mordenti
J
J
Marsters
S A
SA
Gregory
T
T
Mitsuya
H
H
Byrn
R A
RA
Lucas
C
C
Wurm
F M
FM
Groopman
J E
JE
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics; D000818:Animals; D000954:Antigens, Surface / Q000008:administration & dosage / Q000138:chemical synthesis / Q000276:immunology*; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D015815:Cell Adhesion Molecules; D002460:Cell Line; D015195:Drug Design; D015699:HIV Envelope Protein gp120; D006207:Half-Life; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000378:metabolism; D051379:Mice; D011817:Rabbits; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D015728:Receptors, HIV; D011991:Receptors, Virus / Q000008:administration & dosage / Q000276:immunology*; D012191:Retroviridae Proteins / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D015699:HIV Envelope Protein gp120; D007074:Immunoglobulin G; D011951:Receptors, Complement; D011961:Receptors, Fc; D015728:Receptors, HIV; D011991:Receptors, Virus; D012191:Retroviridae Proteins