[The role of niacin in regulating the pentosophosphate pathway and production of NADP-H in fatty tissue].
A study was made of the effect of alimentary deficiency of niacin and of exogenous nicotinamide (500 mg/kg) on the activity of the key enzymes of the pentose phosphate pathway and NADP-dependent malate and isocitric dehydrogenase in the epididymal fatty tissue of rats. It is established that vitamin depletion in the animals' body brings about a 3-fold decrease in the content of NADP+ and a 1.7-fold decrease in the content of NADPH, a 43-percent inhibition of the activity of glucose 6-phosphate dehydrogenase and a 39-percent reduction with respect to transketolase. Nicotinamide suppresses the activity of glucose 6-phosphate dehydrogenase by 35% and that of isocitric dehydrogenase by 40% 12 hours after intraperitoneal injection. It is suggested that NADPH production in the fatty tissue of rats undergoes appreciable changes under the effect of niacin.
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D000273:Adipose Tissue / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009249:NADP / Q000096:biosynthesis*; D009525:Niacin / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D010427:Pentose Phosphate Pathway; D051381:Rats
D009536:Niacinamide; D009525:Niacin; D009249:NADP; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Rol' niatsina v reguliatsii pentozofosfatnogo puti i produktsii NADF-N v zhirovoĭ tkani.