Pure akinesia due to lewy body Parkinson's disease: a case with pathology.
The case of a patient with levodopa-responsive pure akinesia and freezing of gait for 17 years, whose brain showed the classical changes of Lewy body Parkinson's disease at postmortem is presented. A short trial of DL-threo-DOPS was ineffective. Intellectual function was preserved despite the presence of Lewy bodies and mild cell loss in subcortical cholinergic nuclei. Pure akinesia is likely to be a heterogeneous condition, with most cases having little or no response to levodopa therapy. However, this case demonstrates that this clinical picture may be caused by Lewy body Parkinson's disease.
Quinn
N P
NP
University Department of Clinical Neurology, Institute of Psychiatry, London, England.
Luthert
P
P
Honavar
M
M
Marsden
C D
CD
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008125:Locus Coeruleus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology
D000978:Antiparkinson Agents