Low-fat, high-fiber diet and serum estrone sulfate in premenopausal women.
The effect of diet on serum estrogen levels was investigated in 17 healthy premenopausal women consuming defined diets prepared in a metabolic unit. During an initial 4-wk control period all women consumed a typical Western diet (40% of total calories from fat, 400 mg cholesterol/d, 12 g dietary fiber/d, and a ratio of polyunsaturated to saturated fatty acids [P:S] of 0.5). After this control period they were switched to a low-fat, high-fiber diet for 8-10 wk, which consisted of 25% of calories from fat, P:S of 1.0, cholesterol of 200 mg cholesterol/d, and 40 g dietary fiber/d. Compared with the control period 16 of 17 women had lower serum estrone sulfate levels on the low-fat, high-fiber diet. There was an average decrease of 36% with mean levels decreasing from 2.11 +/- 0.25 nmol/L (means +/- SEM) on the control diet to 1.29 +/- 0.19 nmol/L on the experimental diet (p less than 0.001). We conclude that a low-fat, high-fiber diet can significantly reduce serum estrone sulfate levels.
Woods
M N
MN
Department of Community Health, Tufts University School of Medicine, Boston, MA 02111.
Gorbach
S L
SL
Longcope
C
C
Goldin
B R
BR
Dwyer
J T
JT
Morrill-LaBrode
A
A
D000328:Adult; D000728:Androgens / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage*; D004967:Estrogens / Q000097:blood; D004970:Estrone / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans
D000728:Androgens; D004041:Dietary Fats; D004043:Dietary Fiber; D004967:Estrogens; D004970:Estrone; C017296:estrone sulfate