[Antioxidant activity of ubiquinone-9 and its combinations with vitamin E and sodium selenite in toxic lesions of the liver].
It was established that ubiquinone-9 (30 mg/kg per course) decreases in rats the content of primary products of lipid peroxidation--diene conjugates--in the liver by 12 times greater than vitamin E (a course dose of 30 mg/kg). Ubiquinone-9, vitamin E and sodium selenite (a course dose of 90 mg/kg) equally reduced the content of a secondary product of lipid peroxidation--malon dialdehyde. In this case the activity of sodium selenite was 300 times higher than the activity of ubiquinone-9 and vitamin E. The use of ubiquinone-9 in combination with vitamin E and sodium selenite potentiated the antioxidant effect.
Vinogradova
L F
LF
Kharlitskaia
E V
EV
Mirzoian
Zh A
ZhA
D000818:Animals; D000975:Antioxidants; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*; D018038:Sodium Selenite; D013997:Time Factors; D014451:Ubiquinone / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014992:Xylenes / Q000633:toxicity
D000975:Antioxidants; D014992:Xylenes; D014451:Ubiquinone; D014810:Vitamin E; C000294:hexachloro-4-xylene; D012643:Selenium; D018038:Sodium Selenite; C030571:ubiquinone 9
Antioksidantnaia aktivnost' ubikhinona-9 i ego kombinatsiĭ s vitaminom E i selenitom natriia pri toksicheskom porazhenii pecheni.