[First transplantation of embryonic serotonergic neurons in primate spinal cord].
Three adult monkeys (Macaca fascicularis) underwent a total section of the spinal cord at thoracic level (T6). 1 week later, two of them received at T8 level an injection of a cellular suspension prepared from the raphe region of a foetal macaque 39 days old. The third animal received one injection of buffer solution. 1 month later, the animals were sacrificed, and their spinal cord was processed for the immunocytochemical detection of serotonin with light and electron microscopy. Serotonergic neurons had survived after transplantation, and had grown axons and dendrites. Afferent and efferent synapses to serotonergic neurons were readily identified.
Rajaofetra
N
N
Laboratoire de Neurobiologie du Développement, I.N.S.E.R.M., U. 249, C.N.R.S. U.P.R., Montpellier.
Poulat
P
P
Marlier
L
L
Proust
F
F
Drian
M J
MJ
Passagia
J G
JG
Verschuere
B
B
Konig
N
N
Gouy
D
D
Privat
A
A
D000818:Animals; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D008297:Male; D009474:Neurons / Q000032:analysis / Q000166:cytology / Q000637:transplantation*; D012701:Serotonin / Q000032:analysis; D013116:Spinal Cord / Q000601:surgery*; D013569:Synapses
D012701:Serotonin
Première transplantation de neurones sérotonergiques embryonnaires dans la moelle épinière d'un primate.