Structural parts involved in activation and inactivation of the sodium channel.
Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.
Stühmer
W
W
Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.
Conti
F
F
Suzuki
H
H
Wang
X D
XD
Noda
M
M
Yahagi
N
N
Kubo
H
H
Numa
S
S
D000200:Action Potentials; D000818:Animals; D004247:DNA; D009154:Mutation; D010063:Ovum; D010957:Plasmids; D015222:Sodium Channels; D013329:Structure-Activity Relationship; D014162:Transfection; D014981:Xenopus
D015222:Sodium Channels; D004247:DNA