title: Beta-thioglucose inhibits gold thioglucose lesions in the ventromedial hypothalamus.
abstract: Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabolite, on GTG-induced lesions in the VMH of mice. Twenty-eight female CF-1 mice were used in this study. Seven micron sections were made of the mouse VMH, mounted on glass slides, and stained with hematoxylin and eosin. A previous report of BTG action on GTG-induced lesions has not supported a competitive inhibition between these two drugs. Our data demonstrate that at 1/2 hour, 6 hours, and 12 hours post BTG, BTG completely inhibited GTG-induced lesions in the VMH.
authors.affiliation: Department of Anatomy, University of Health Sciences, College of Osteopathic Medicine, Kansas City, MO 64124.
authors.forename: D F
authors.initials: DF
authors.lastname: Brown
authors.forename: J P
authors.initials: JP
authors.lastname: McGuirk
authors.forename: S P
authors.initials: SP
authors.lastname: Larsen
authors.forename: S D
authors.initials: SD
authors.lastname: Minter
mesh_terms: D000818:Animals; D006051:Aurothioglucose / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006046:Gold / Q000009:adverse effects*; D051379:Mice; D013997:Time Factors; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects* / Q000473:pathology
chemical_list: D006051:Aurothioglucose; D006046:Gold; C018399:1-thioglucose; D005947:Glucose