title: The effect of new monofilament absorbable sutures on the healing of musculoaponeurotic incisions, gastrotomies, and colonic anastomoses.
abstract: The purpose of this study was to quantitate the effect of two new synthetic monofilament absorbable sutures, Maxon and PDS, on the healing of musculoaponeurotic incisions, gastrotomies, and colonic anastomoses. Wound healing was assessed by measuring the resistance of the closed wound to leak or burst with controlled infusion of fluid. Bursting strength measurements of these incisions were compared with those undertaken in age-weight matched controls without wounds to determine the rate of gain of wound strength. The bursting strength measurements of unwounded tissue was found to vary according to the age, weight, and specific tissue. As the animals gained weight over 42 days, the bursting strength of their colons and musculoaponeurotic tissues significantly increased. In general, the regain of prewounding bursting strength was inversely proportional to the bursting strength of the unwounded tissue. The bursting strength of abdominal musculoaponeurotic tissue was the highest, followed by the stomach and then the colon. The time intervals in which the wounded musculoaponeurotic tissues, gastrotomies, and colonic anastomoses regained the strength of the unwounded tissue was 42, 14, and 7 days, respectively. The performance of Maxon and PDS sutures in the musculoaponeurotic tissues, gastrotomies, and colonic anastomoses was similar.
authors.affiliation: Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville 22908.
authors.forename: P A
authors.initials: PA
authors.lastname: Foresman
authors.forename: R F
authors.initials: RF
authors.lastname: Edlich
authors.forename: G T
authors.initials: GT
authors.lastname: Rodeheaver
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery*; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery*; D004146:Dioxanes; D008297:Male; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains; D012107:Research Design; D013270:Stomach / Q000601:surgery*; D013536:Suture Techniques; D013537:Sutures; D013718:Tensile Strength; D014945:Wound Healing
chemical_list: D004146:Dioxanes; D011108:Polymers; C046409:polyglyconate; C059814:4-dioxanone