Coupling of viral membrane proteins to phosphatidylinositide signalling system.
C6 rat glioma cells persistently infected with subacute sclerosing panencephalitis virus (C6/SSPE) were treated with measles antiserum and purified anti-measles IgG. This stimulated phosphoinositide breakdown and an increase in inositol phosphates. In uninfected C6 cells, however, only fetal calf serum (FCS), but not measles antiserum could induce inositol polyphosphate production.
Weinmann-Dorsch
C
C
Institut für Virologie und Immunbiologie, Universität Würzburg, FRG.
Koschel
K
K
D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral / Q000276:immunology; D005910:Glioma; D006389:Hemagglutinins, Viral / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism; D007700:Kinetics; D008459:Measles virus / Q000276:immunology; D008565:Membrane Proteins / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D013190:SSPE Virus / Q000502:physiology*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D007106:Immune Sera; D007074:Immunoglobulin G; D007295:Inositol Phosphates; D008565:Membrane Proteins; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D014764:Viral Proteins; D015544:Inositol 1,4,5-Trisphosphate