Venoocclusive lesions of the central veins and portal vein radicles secondary to intraarterial 5-fluoro-2'-deoxyuridine infusion.
Venoocclusive disease is characterized by the occurrence of occlusive lesions of the central and subhepatic veins, usually involving the liver in a diffuse fashion. We report a case showing venoocclusive lesions of the central veins and the portal vein radicles affecting only a portion of the left lobe of the liver following intraarterial 5-fluoro-2'-deoxyuridine therapy for metastatic adenocarcinoma of the colon. Possible mechanisms and the significance of venoocclusive lesions of portal vein radicles are discussed.
Nakhleh
R E
RE
Department of Laboratory Medicine, University of Minnesota, Minneapolis.
Wesen
C
C
Snover
D C
DC
Grage
T
T
D000368:Aged; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy; D011169:Portal Vein / Q000473:pathology*
D005467:Floxuridine