[Comparison of the effects of cicletanine and captopril on kidney and heart lesions in spontaneously hypertensive rats (SHR-SP)].
All studies carried out on stroke-prone spontaneously hypertensive rats (SHR-SP) have clearly demonstrated that cicletanine protects tissues and vessels. This effect has also been observed with captopril. However, the effectiveness of captopril seemed to be dependent on its blood pressure lowering effect, and this was not found with cicletanine in previous experimental studies on SHR-SP. In view of the difference in effectiveness between captopril and cicletanine as regards blood pressure, it was considered important to compare the two compounds in a similar blood pressure complex. In this study, the effects of cicletanine at two dosage levels (3.33 and 10 mg/kg/day) on the tissue and vascular lesions of SHR-SP were compared with those of captopril in doses of 1 mg/kg/day. Iffa Credo SHR-SP rats aged 7 weeks were divided into four groups of 12 animals each: 2 groups received cicletanine 3.33 and 10 mg/kg/day respectively, 1 group received captopril 1 mg/kg/day and 1 group served as control. Blood pressure was recorded once a week. After 44 days of treatment, all animals were killed and autopsied. A significant antihypertensive effect was observed with both captopril (p less than 0.001) and cicletanine 10 mg/kg (p less than 0.05). In doses of 3.33 mg/kg cicletanine induced only a very slight fall in blood pressure, not significantly different from controls. On the other hand, histological and ultrastructural examinations showed better preservation of tissues and, chiefly, vessels with cicletanine at the two dosage levels than with captopril 1 mg/kg.
Ruchoux
M M
MM
Laboratoire d'anatomie pathologique, CHU Bretonneau, Tours, France.
Bakri
F
F
Bosquet
D
D
Droy
M T
MT
Guillemain
J
J
Lhuintre
Y
Y
D000818:Animals; D002216:Captopril / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004232:Diuretics / Q000627:therapeutic use*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D011725:Pyridines; D051381:Rats; D011918:Rats, Inbred SHR
D004232:Diuretics; D011725:Pyridines; D002216:Captopril; C038068:cicletanine
Comparaison des effets du ciclétanine et du captopril sur les lésions rénales et cardiaques du rat spontanément hypertendu (SHR-SP).