[Preventive treatment of infection caused by gram-negative bacteria using anti-lipopolysaccharide antibodies. Evaluation in patients with aplasia].
The prophylaxis of severe Gram-negative infections with human antiserum to lipopolysaccharide (LPS) was evaluated in a randomised study of 60 patients with therapeutic aplasia for leukaemia. The antiserum was found to be ineffective in preventing Gram-negative infections. The levels of anti-LPS antibodies showed that passive immunization was obtained in only one half of the patients. These disappointing results warrant further investigations to evaluate the effectiveness of this prophylactic treatment.
Lecomte
F
F
Laboratoire de Bactériologie, Hôtel Dieu, Rouen.
Tilly
H
H
Grise
G
G
Bastit
D
D
Ropartz
C
C
Lemeland
J F
JF
Humbert
G
G
Monoconduit
M
M
Piguet
H
H
D000328:Adult; D000380:Agranulocytosis; D000906:Antibodies / Q000032:analysis / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D007116:Immunization, Passive / Q000379:methods; D007136:Immunoglobulins; D007938:Leukemia / Q000188:drug therapy; D008070:Lipopolysaccharides / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009503:Neutropenia; D011897:Random Allocation
D000906:Antibodies; D007136:Immunoglobulins; D008070:Lipopolysaccharides; C042866:antilipopolysaccharide antibodies
Traitement préventif des infections à bacille à Gram négatif par des anticorps anti-lipopolysaccharides. Evaluation chez l'aplasique.