title: Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits.
abstract: 1. It has been suggested that beta 2-adrenoreceptors in skeletal muscle regulate plasma potassium. The possibility that alterations in the function and/or density of these receptors occurs in perinephritis hypertension in rabbits was studied. 2. Intravenous infusion of adrenaline (0.2 micrograms kg-1 min-1) caused a fall in potassium while intravenous bolus injection of propranolol (0.75 mg kg-1) resulted in an increase in serum potassium which was of similar magnitude in both perinephritis hypertensive and sham-operated normotensive rabbits. 3. Binding studies with the radioligand [125I] cyanopindolol (ICYP) showed that there were no significant differences between the hypertensive and normotensive rabbits in the density (Bmax) or affinity (KD) of the skeletal muscle beta 2-adrenoreceptor. 4. The results suggest that function and density of skeletal muscle beta 2-adrenoreceptors are not altered in rabbits with perinephritis hypertension.
authors.affiliation: Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Elfellah
authors.forename: C A
authors.initials: CA
authors.lastname: Hamilton
authors.forename: W
authors.initials: W
authors.lastname: McIntosh
authors.forename: S M
authors.initials: SM
authors.lastname: Barr
authors.forename: C
authors.initials: C
authors.lastname: Howie
authors.forename: J L
authors.initials: JL
authors.lastname: Reid
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006977:Hypertension, Renal / Q000097:blood / Q000378:metabolism*; D007457:Iodine Radioisotopes; D020120:Iodocyanopindolol; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010501:Perinephritis / Q000150:complications*; D010869:Pindolol / Q000031:analogs & derivatives; D011188:Potassium / Q000097:blood*; D011817:Rabbits; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D020120:Iodocyanopindolol; D010869:Pindolol; D011188:Potassium; D004837:Epinephrine