[1'-carbon hydroxylation of deoxyribose as the mechanism of cleavage of poly(dA) by manganese porphyrin combined with potassium monopersulfate].
Polyadenylic acid, poly(dA), was readily cleaved at neutral pH by meso-tetrakis (4-N-methylpyridyl) porphyrinatomangangeseIII pentaacetate after being activated by potassium monopersulfate. Spontaneously free adenine was released, and after heating an unstable sugar degradation product identified as 5-methylene-2-furanone was evidenced, indicating that C'1-H is the main target of the porphyrin high-valent metal-oxo species.
Bernadou
J
J
Laboratoire de Chimie de Coordination du C.N.R.S., Toulouse.
Lauretta
B
B
Pratviel
G
G
Meunier
B
B
D000225:Adenine / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003855:Deoxyribose / Q000378:metabolism*; D005663:Furans / Q000378:metabolism; D006900:Hydroxylation; D007700:Kinetics; D008665:Metalloporphyrins / Q000494:pharmacology*; D011061:Poly A / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D013431:Sulfates / Q000494:pharmacology*
D005663:Furans; D008665:Metalloporphyrins; D017680:Potassium Compounds; D013431:Sulfates; D011061:Poly A; C015465:poly(dA); D003855:Deoxyribose; C037354:protoanemonin; C009007:potassium persulfate; C050950:tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex; D000225:Adenine; D011188:Potassium
Sur l'hydroxylation du carbone-1' du déoxyribose comme mécanisme de coupure du poly(dA) par une porphyrine de manganèse associée au monopersulfate de potassium.