Investigation of varicella-zoster virus infection of lymphocytes by in situ hybridization.
Peripheral blood mononuclear cells harboring viral gene sequences were detected during primary varicella-zoster virus (VZV) infection of the human host and the strain 2 guinea pig by in situ hybridization with a 3H-labeled VZV DNA probe. Activated T lymphocytes were permissive for VZV infection at low frequency in vitro.
Koropchak
C M
CM
Department of Pediatrics, Stanford University School of Medicine, California 94305.
Solem
S M
SM
Diaz
P S
PS
Arvin
A M
AM
D000818:Animals; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis; D006168:Guinea Pigs; D006562:Herpes Zoster / Q000175:diagnosis*; D014645:Herpesvirus 3, Human / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D013045:Species Specificity
D015342:DNA Probes; D004279:DNA, Viral