Chronic paroxysmal hemicrania: a chronobiological study (case report).
In this study the 24-h pattern of blood pressure (BP), heart rate (HR), plasma catecholamine (CA), beta-endorphin (beta-EP), beta-lipotropin (beta-LPH) and RIII threshold was investigated in a patient suffering from chronic paroxysmal hemicrania (CPH). The investigation was carried out before and during indomethacin therapy in order to assess the presence or otherwise of a disordered biorhythmic organization resembling that documented in cluster headache (CH). A severe alteration in the majority of the rhythms explored was found not only during the drug-free phase, but also in the indomethacin phase of the investigation. These data are similar to those obtained in CH studies and point to the possibility of a common pathophysiological mechanism.
Micieli
G
G
Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.
Cavallini
A
A
Facchinetti
F
F
Sances
G
G
Nappi
G
G
D000328:Adult; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D002908:Chronic Disease; D002940:Circadian Rhythm; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D001615:beta-Endorphin / Q000097:blood; D008083:beta-Lipotropin / Q000097:blood
D002395:Catecholamines; D001615:beta-Endorphin; D008083:beta-Lipotropin; D007213:Indomethacin