title: The P300 event-related potential and regional cerebral blood flow in patients with Alzheimer's disease.
abstract: A number of studies have reported that an abnormal delay in the latency of the P300 event-related potential (ERP) is characteristic of the majority of patients with a dementing process. Another body of research suggests regional cerebral blood flow (rCBF) is significantly reduced in Alzheimer's disease (AD). No previous study has compared the effectiveness of these 2 measures in identifying the same patients with AD. Furthermore, most of the studies on which the above findings are based examined patients in the moderate to severe stages of the disorder. In this study we examined P300 latency and rCBF in 10 patients with mild to moderate Alzheimer's disease, and compared their responses with those of normal subjects of similar age. The P300 component was not evident in 2 of the patients: the remaining 8 had a latency within normal limits for their age. On the other hand, 8 of the patients had abnormally reduced rCBF. These results suggest rCBF measures may be useful for identifying AD in its early stages.
authors.affiliation: Neuroscience Unit, University of Sydney and Westmead Hospital, NSW.
authors.forename: E
authors.initials: E
authors.lastname: Gordon
authors.forename: C
authors.initials: C
authors.lastname: Kraiuhin
authors.forename: Y
authors.initials: Y
authors.lastname: Zurynski
authors.forename: C
authors.initials: C
authors.lastname: Rennie
authors.forename: P
authors.initials: P
authors.lastname: Landau
authors.forename: A
authors.initials: A
authors.lastname: Singer
authors.forename: A
authors.initials: A
authors.lastname: Howson
authors.forename: R
authors.initials: R
authors.lastname: Meares
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004566:Electrodes; D005071:Evoked Potentials / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014980:Xenon Radioisotopes
chemical_list: D006454:Hemoglobins; D014980:Xenon Radioisotopes; D002245:Carbon Dioxide