[Results of using polyvalent Pseudomonas aeruginosa vaccine in children with burns by various medical centers].
Polyvalent Pseudomonas aeruginosa vaccine, prepared at the Institute of Hematology from 10 hospital strains isolated from burn wounds, was administered to 32 children with extensive and deep burns. The vaccine was well tolerated. The vaccine produced a high degree of the immunity against Pseudomonas aeruginosa infection. Agglutinin serum titre increased significantly. Vaccination either prevented or inhibited the infection of burn wounds with Pseudomonas aeruginosa in all immunized children. The symptoms of Pseudomonas aeruginosa infection usually disappeared following one or two vaccinations. Bacteriemia caused by P. aeruginosa was not observed in 31 out of 32 children. In the remaining child transient bacteriemia was noted. No septicemia caused by P. aeruginosa was seen. Due to the high efficiency of the polyvalent P. aeruginosa vaccine all burned children with burns exceeding 10% of the total body surface should by vaccinated to prevent the life-threatening infections with Pseudomonas aeruginosa.
Bbukowska
D
D
Serafińska
D
D
Rudowski
W
W
Hoffman
S
S
Olański
W
W
Gardzińska
E
E
Popiel
D
D
Jedrzejczak
G
G
Czarnecka
I
I
D000373:Agglutinins / Q000032:analysis; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002056:Burns / Q000150:complications* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011044:Poland; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D014946:Wound Infection / Q000276:immunology / Q000517:prevention & control*
D000373:Agglutinins; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
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