Aortic cyclic AMP levels in hypertensive rats.
The levels of adenosine 3':5' cyclic monophosphate (cyclic AMP) were measured in aortae from 2-kidney, 1-clip renovascular hypertensive and DOCA-salt hypertensive rats. Cyclic AMP concentration and content were increased in the arteries from the hypertensive animals compared to their normotensive controls. There was a significant positive linear correlation between aortic cyclic AMP concentration and blood pressure and between aortic cyclic AMP content and blood pressure. Since cyclic AMP has been shown to be involved in cellular proliferation and protein synthesis, a perturbation in the normal functioning of this second messenger system could be related to some of the vascular changes associated with the hypertensive process.
Mangiarua
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EI
Department of Physiology, School of Medicine, Marshall University, Huntington, WV 25704-2901.
Wright
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GL
McCumbee
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WD
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D006978:Hypertension, Renovascular / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D000242:Cyclic AMP