Outbreak of poliomyelitis in South Africa investigated by oligonucleotide mapping.
An outbreak of paralytic poliomyelitis, due to polio type 1 virus, occurred in the Gazankulu region of the Transvaal in the Republic of South Africa in 1982. Thirty-four different isolates from this epidemic were characterized by oligonucleotide mapping. None of the isolates were shown to be vaccine related. Results suggest the existence of a number of apparently different wild-type viruses present in the area. The introduction of a single wild-type strain could not be clearly demonstrated. These findings have important implications for the management and control of future outbreaks.
Tsilimigras
C W
CW
National Institute for Virology, University of the Witwatersrand Medical School, Johannesburg, Republic of South Africa.
Rossouw
E
E
Schoub
B D
BD
D004196:Disease Outbreaks; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D009710:Nucleotide Mapping; D011051:Poliomyelitis / Q000453:epidemiology* / Q000382:microbiology; D017955:Poliovirus / Q000235:genetics / Q000302:isolation & purification*; D012367:RNA, Viral; D013019:South Africa; D013045:Species Specificity
D012367:RNA, Viral