title: Role of thiols in human peripheral blood natural killer and killer lymphocyte activities.
abstract: The thiol reagents, dithiothreitol, diethyldithiocarbamate and reduced glutathione were each found to inhibit Natural Killer and Killer lymphocyte-mediated cytotoxicities. A biphasic aspect to the inhibition with increasing concentration was observed with diethyldithiocarbamate and reduced glutathione. The inhibition observed in response to reduced glutathione, a non-permeant compound, suggests that cell surface thiols may be critical functional groups in the processes of NK and K lymphocyte-mediated cytotoxicities.
authors.affiliation: National Institute of Occupational Health and Safety, University of Sydney, NSW, Australia.
authors.forename: N H
authors.initials: NH
authors.lastname: Stacey
authors.forename: G K
authors.initials: GK
authors.lastname: Craig
mesh_terms: D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004229:Dithiothreitol / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D013438:Sulfhydryl Compounds; D004050:Ditiocarb; D005978:Glutathione; D004229:Dithiothreitol