title: Brain natriuretic peptides: differential localization of a new family of neuropeptides.
abstract: Brain natriuretic peptide (BNP) is a recently discovered neuropeptide, isolated from the porcine brain, that is highly homologous to atriopeptin (AP), the atrial natriuretic peptide. We used a set of highly selective antisera against the two peptides to map their differential distribution immunohistochemically in the rat central nervous system. BNP immunoreactivity has a distinct distribution, involving many central autonomic and endocrine control structures that contain little if any AP immunoreactivity. AP and BNP belong to a family of neuropeptides that may be important in central cardiovascular control.
authors.affiliation: Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637.
authors.forename: C B
authors.initials: CB
authors.lastname: Saper
authors.forename: K M
authors.initials: KM
authors.lastname: Hurley
authors.forename: M M
authors.initials: MM
authors.lastname: Moga
authors.forename: H R
authors.initials: HR
authors.lastname: Holmes
authors.forename: S A
authors.initials: SA
authors.lastname: Adams
authors.forename: K M
authors.initials: KM
authors.lastname: Leahy
authors.forename: P
authors.initials: P
authors.lastname: Needleman
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor