title: Therapy of advanced gastric carcinoma. The Georgetown-Lombardi Cancer Center experience.
abstract: Gastric carcinoma, despite a decreasing incidence in the United States over the past 40 years, is the seventh most common cause of cancer death in this country and remains a significant worldwide problem. The 5-fluorouracil, Adriamycin (doxorubicin), and mitomycin (FAM) chemotherapy regimen, which was initially reported by Georgetown in 1979, has become a standard for advanced gastric carcinoma with response rates in the 40% range. The FAM regimen as well as subsequent trials conducted at Georgetown and our current approach to management of this tumor are discussed. Despite a decade of intensive clinical research, we have not identified a modification or innovation that is superior to the original FAM.
authors.affiliation: Medical College of Pennsylvania, Division of Hematology-Oncology, Philadelphia 19129.
authors.forename: J
authors.initials: J
authors.lastname: Treat
authors.forename: S C
authors.initials: SC
authors.lastname: Falchuk
authors.forename: P V
authors.initials: PV
authors.lastname: Woolley
authors.forename: J D
authors.initials: JD
authors.lastname: Ahlgren
authors.forename: J R
authors.initials: JR
authors.lastname: Neefe
authors.forename: F P
authors.initials: FP
authors.lastname: Smith
authors.forename: J S
authors.initials: JS
authors.lastname: Macdonald
authors.forename: P S
authors.initials: PS
authors.lastname: Schein
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D005493:Folic Acid Antagonists / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D013311:Streptozocin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005641:Tegafur / Q000008:administration & dosage; D014227:Triazines / Q000008:administration & dosage
chemical_list: D005493:Folic Acid Antagonists; D008937:Mitomycins; D014227:Triazines; D005641:Tegafur; C007028:chlorozotocin; D016685:Mitomycin; D013311:Streptozocin; D004317:Doxorubicin; C012071:triazinate; D002945:Cisplatin; D005472:Fluorouracil