Prostaglandin E2 and F2 alpha inhibit growth of human gastric carcinoma cell line KATO III with simultaneous stimulation of cyclic AMP production.
The effects of prostaglandins (PGs) on the growth of human gastric carcinoma cell line KATO III were investigated. PGE2 as well as PGF2 alpha significantly and dose-dependently inhibited the growth of this gastric carcinoma cell line (PGE2 greater than PGF2 alpha). This inhibition of cell growth by the PGs was associated with the increase in cyclic AMP production (PGE2 greater than PGF2 alpha), whereas inositol-phospholipid turnover was not affected by either PGE2 or PGF2 alpha as assessed by the formation of 3H-inositol phosphates. Furthermore, the proliferation of these gastric carcinoma cells was also suppressed by the administration of forskolin as well as of dibutyryl cyclic AMP. These results suggest that PGE2 and PGF2 alpha inhibit the growth of cultured human gastric carcinoma cells KATO III via stimulation of cyclic AMP production.
Nakamura
A
A
Third Department of Internal Medicine, Kobe University School of Medicine, Japan.
Chiba
T
T
Yamatani
T
T
Yamaguchi
A
A
Inui
T
T
Morishita
T
T
Kadowaki
S
S
Fujita
T
T
D003994:Bucladesine / Q000494:pharmacology; D002277:Carcinoma / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis*; D003864:Depression, Chemical; D015237:Dinoprost / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D006801:Humans; D007295:Inositol Phosphates / Q000096:biosynthesis; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D007295:Inositol Phosphates; D005576:Colforsin; D003994:Bucladesine; D015237:Dinoprost; D000242:Cyclic AMP; D015232:Dinoprostone