Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone.
The supernatants of the human alloreactive helper T cell clone A1, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cell and expression of Fc epsilon R2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-IL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.
Vercelli
D
D
Division of Allergy and Immunology, Children's Hospital Boston, Mass.
Leung
D Y
DY
Jabara
H H
HH
Geha
R S
RS
D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D002478:Cells, Cultured; D002999:Clone Cells; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D066298:In Vitro Techniques; D015847:Interleukin-4; D007378:Interleukins / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008222:Lymphokines / Q000502:physiology; D009000:Monocytes / Q000276:immunology; D011961:Receptors, Fc / Q000502:physiology*; D017455:Receptors, IgE; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000944:Antigens, Differentiation, B-Lymphocyte; D007378:Interleukins; D008222:Lymphokines; D011961:Receptors, Fc; D017455:Receptors, IgE; D015847:Interleukin-4; D007073:Immunoglobulin E