Alternative splicing of human insulin receptor messenger RNA.
The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding alpha-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.
Seino
S
S
Howard Hughes Medical Institute, Department of Biochemistry, University of Chicago, IL 60637.
Bell
G I
GI
D000328:Adult; D000595:Amino Acid Sequence; D001482:Base Composition; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D003001:Cloning, Molecular; D005091:Exons; D005784:Gene Amplification; D006801:Humans; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D008969:Molecular Sequence Data; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics*; D011994:Recombinant Proteins; D014018:Tissue Distribution; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D011994:Recombinant Proteins; D011972:Receptor, Insulin