Estimation of technetium-99m-MAG3 plasma clearance in adults from one or two blood samples.
Technetium-99m mercaptoacetyltriglycine (MAG3) clearance is strongly correlated with effective renal plasma flow and can be used directly as a measure of renal function. For these reasons, formulas were developed for estimation of [99mTc]MAG3 clearance based on one or two plasma samples. A two-exponential model provided an excellent fit for 8-point plasma clearance curves obtained from 35 patients having a wide range of renal function. The 8-point [99mTc]MAG3 clearance could be estimated from a single point at 43 min with an error of 19 ml/min (residual s.d.) or from two samples at 12 and 94 min with an error of 7 ml/min. The relative errors with MAG3 are thus comparable to those reported for similar techniques used with [131I]orthoiodohippurate, [99mTc]diethylenetriaminepentraacetic acid and [51Cr]ethylenediaminetetraacetic acid.
Russell
C D
CD
Division of Nuclear Medicine, University of Alabama, Birmingham 35233.
Taylor
A
A
Eshima
D
D
D000328:Adult; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009842:Oligopeptides / Q000097:blood / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000097:blood / Q000378:metabolism*; D011866:Radioisotope Renography; D017263:Technetium Tc 99m Mertiatide
D009842:Oligopeptides; D015609:Organotechnetium Compounds; D017263:Technetium Tc 99m Mertiatide