Anticardiolipin antibodies are elevated in HIV-1 infected haemophiliacs but do not predict for disease progression.
Levels of anticardiolipin antibodies (ACA) were measured in 55 patients with haemophilia A in serum samples obtained in 1983 and in 1987. Twenty-one patients were negative for anti HIV-1 antibodies in 1983 and remained negative in 1987; 34 patients had anti HIV-1 antibodies in 1983; 17 of these latter patients remained asymptomatic, whereas 17 patients developed ARC or AIDS during the 4 years follow-up. Thirteen anti HIV-1 negative patients had elevated ACA levels in 1983; subsequently, a significant decrease was observed in all these subjects (p less than 0.001). All anti HIV-1 positive patients had elevated ACA levels in 1983; normal values were found in 9 patients in 1987. Yet, these changes were not significant (p greater than 0.05). ACA levels were significantly higher in HIV-1 infected patients than in those without anti HIV-1 antibodies (p less than 0.05). There was no difference of ACA levels between the two anti HIV-1 positive patient groups, be it in 1983 or be it in 1987 (p greater than 0.05). There was no correlation of ACA levels with serum IgG concentrations, CD4+ lymphocytes, or the consumption of factor VIII concentrates.
Panzer
S
S
First Medical Clinic, University of Vienna, Austria.
Stain
C
C
Hartl
H
H
Dudczak
R
R
Lechner
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000378:metabolism*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D015331:Cohort Studies; D005169:Factor VIII / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007958:Leukocyte Count; D008875:Middle Aged; D011379:Prognosis; D011863:Radioimmunoassay; D006377:T-Lymphocytes, Helper-Inducer
D001323:Autoantibodies; D002308:Cardiolipins; D007074:Immunoglobulin G; D005169:Factor VIII