[Is ethanol a stressogenic factor for rats with a developed alcohol motivation?].
The male outbred rats, placed in common cages, demonstrated dose- and time-dependent increase of blood plasma ACTH level after handling and acute ethanol administration (1 and 4 g/kg). The pituitary response of isolated rats under condition of free choice between water and 15% ethanol solution was more pronounced after handling. Ethanol (4 g/kg) did not increase plasma blood level ACTH in isolated alcohol motivated rats. It also prevented blood plasma ACTH rise under condition of handling. The dual role of acute ethanol as a stressogenic and antistressogenic factor in naive and alcoholic rats is discussed.
Vedernikova
N N
NN
Borisova
I P
IP
Orekhov
S N
SN
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000428:Alcohol Drinking; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009042:Motivation / Q000187:drug effects*; D051381:Rats; D012934:Social Isolation; D013312:Stress, Physiological / Q000097:blood / Q000139:chemically induced*; D013997:Time Factors
D000431:Ethanol; D000324:Adrenocorticotropic Hormone
Iavliaetsia li étanol stressogennym faktorom dlia krys so sformirovannoĭ alkogol'noĭ morivatsieĭ?