[Induction of differentiation of human promyelocytic leukemia (HL-60) cells by new retinoid R-81001].
By using soft agar colony-forming assay, a monoclonal subline of human promyelocytic leukemia HL-60 cells was isolated and inducing activity of differentiation of a new retinoid R-81001 on the cells was studied. Phenotypic changes, such as biologic behavior, morphological and biochemical characteristics, show that R-81001 can induce HL-60 cells to differentiate along the myeloid pathway.
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D000970:Antineoplastic Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D014212:Tretinoin; C044489:N-(4-aminosulfonylphenyl)retinamide