Comparative study of the immunogenicity of aqueous versus aluminium phosphate adsorbed split influenza vaccine C.I.
The antibody responses induced by the split influenza vaccine adsorbed on aluminium phosphate and the corresponding, nonadsorbed vaccine, both prepared in the Cantacuzino Institute, were studied in subjects belonging to three different age groups: 3-6, 10-15 and over 60 years of age, respectively. In all age groups the immunogenicity of the two vaccine preparations was similar, being uninfluenced by the level of preexisting antibodies. The immunogenicity of both vaccines was similar even in children considered to be non-primed. There were no differences in the persistence and specificity of antibodies induced by the two vaccines. No significant enhancement of the immunogenicity by aluminium phosphate was observed.
Ioniţă
E
E
Lupulescu
E
E
Alexandrescu
V
V
Maţepiuc
M
M
Constantinescu
C
C
Creţescu
L
L
Velea
L
L
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000327:Adsorption; D000535:Aluminum / Q000276:immunology*; D017607:Aluminum Compounds; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D006385:Hemagglutination Inhibition Tests; D006462:Hemolytic Plaque Technique; D006801:Humans; D007115:Immunization Schedule; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D008875:Middle Aged; D010710:Phosphates / Q000276:immunology*
D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010710:Phosphates; D000535:Aluminum; C012714:aluminum phosphate