title: Clinical comparison of I-131 orthoiodohippurate and the kit formulation of Tc-99m mercaptoacetyltriglycine.
abstract: Previous studies in animals and humans have shown that technetium-99m mercaptoacetyltriglycine (MAG3) purified by high-performance liquid chromatography is a renal tubular agent with characteristics similar to those of iodine-131 orthoiodohippurate (OIH). A kit formulation for Tc-99m MAG3 has been developed and compared with I-131 OIH in 17 patients with suspected renal dysfunction and three potential kidney donors. There were no adverse reactions. Tc-99m MAG3 images were of good quality and consistently better than I-131 OIH images. There was no significant difference in the relative renal uptake of Tc-99m MAG3 and I-131 OIH. The 30-minute urinary excretion of Tc-99m MAG3 was 36.4%, versus 40.4% for I-131 OIH. The average plasma clearance of Tc-99m MAG3 (138 mL/min +/- 117) was less than that of I-131 OIH (272 mL/min +/- 205) (P less than .001); however, there was good correlation between the Tc-99m MAG3 and I-131 OIH clearances (r = .87). The volume of distribution of Tc-99m MAG3 (5.96 L +/- 1.94) was less than that of I-131 OIH (9.41 L +/- 3.73) (P less than .001). These characteristics and the advantages of a simple kit formulation should lead to widespread clinical use.
authors.affiliation: Department of Radiology, Emory University School of Medicine, Atlanta, GA.
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: J A
authors.initials: JA
authors.lastname: Ziffer
authors.forename: A
authors.initials: A
authors.lastname: Steves
authors.forename: D
authors.initials: D
authors.lastname: Eshima
authors.forename: V B
authors.initials: VB
authors.lastname: Delaney
authors.forename: J D
authors.initials: JD
authors.lastname: Welchel
mesh_terms: D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D013667:Technetium; D017263:Technetium Tc 99m Mertiatide
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D011933:Reagent Kits, Diagnostic; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium