[Neurotoxicity in long-term lithium therapy: an electroneurographic study].
In a series of 16 patients on long-term lithium therapy pathological changes were found in peripheral nerve conduction. Such changes correlated with the duration of lithium therapy (mean: 8.3 years, range: 3-15 years; p less than 0.05). No patient showed clinical signs of polyneuropathy or any other disease known to be frequently associated with peripheral nerve lesions. Compared with an age-matched normal control group (n = 27) the nerve conduction velocity of the sural nerve was reduced (p less than 0.05), for which a chronic neurotoxic effect is considered to be the most probable mechanism.
Eisenstädter
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A
Neurologische Abteilung, NO Landeskrankenhaus Klosterneuburg.
Seiser
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A
Brainin
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M
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D016651:Lithium Carbonate; D008134:Long-Term Care; D008297:Male; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D010525:Peripheral Nerves / Q000187:drug effects*; D010543:Peroneal Nerve / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D016651:Lithium Carbonate; D008094:Lithium
Neurotoxizität bei Langzeit-Lithiumtherapie: eine elektroneurographische Studie.