title: Five-year results of combined chemotherapy and mediastinal radiation therapy in small cell lung cancer.
abstract: Eighty-five patients with small cell lung cancer (limited disease = LD in 39, extensive disease = ED in 46) received the combination of cyclophosphamide, methotrexate, vincristine and CCNU, and mediastinal radiotherapy given simultaneously after the third course of chemotherapy. The duration of treatment was approximately 12 months. A complete response was obtained in 41% of LD and in 15% of ED patients, and a partial response in 38 and 22%, respectively. Median survival was 55 weeks for LD and 37 weeks for ED patients. Two patients (5%) with LD have survived free of disease more than 3 years since their diagnosis.
authors.affiliation: Department of Oncology and Radiotherapy, Hospital General Vall d'Hebron, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Bonfill
authors.forename: A
authors.initials: A
authors.lastname: Lafuerza
authors.forename: E
authors.initials: E
authors.lastname: Saigi
authors.forename: H
authors.initials: H
authors.lastname: Palombo
authors.forename: J
authors.initials: J
authors.lastname: Carulla
authors.forename: R
authors.initials: R
authors.lastname: Fuentes
authors.forename: D
authors.initials: D
authors.lastname: Rubio
authors.forename: L
authors.initials: L
authors.lastname: Sole
mesh_terms: D018288:Carcinoma, Small Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D008482:Mediastinum / Q000528:radiation effects*; D013997:Time Factors