title: Optimal input design: case study of the metabolic process.
abstract: An optimal input of nutrients into the metabolic process of the individual subject so as to effect desired therapeutic results is particularly important for the critically ill. A patient-related, individualized nutrients optimization procedure is proposed here. The procedure is applicable to any time-invariant and deterministic metabolic model that is bound by one or more quantitative limiting criteria. As a case in hand, the procedure is used to optimize the individual metabolic needs of critically ill patients. The results indicate that, given a proper metabolic model, the patient may be treated on an individual appropriateness basis rather than on the traditional statistical intuitive approach.
authors.forename: R
authors.initials: R
authors.lastname: Giladi
authors.forename: S
authors.initials: S
authors.lastname: Sideman
mesh_terms: D003422:Critical Care; D006801:Humans; D008433:Mathematics; D008660:Metabolism; D008954:Models, Biological; D009751:Nutritional Requirements