Anti-CD45RA antibodies increase the proliferation of mouse T cells to phytohemagglutinin through the interleukin 2/interleukin 2 receptor pathway.
We have studied the effect of anti-CD45RA monoclonal antibodies on the proliferation of murine spleen T cells activated with phytohemagglutinin. Antibodies act on both CD8 and CD4 subsets of T cells. They seem to replace a signal normally delivered by accessory cells which would act through the interleukin 2/interleukin 2 receptor pathway.
Marvel
J
J
Department of Biology, University College, London.
Poirier
G
G
Lightstone
E
E
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000938:Antigen-Presenting Cells / Q000276:immunology; D000943:Antigens, Differentiation / Q000502:physiology*; D006649:Histocompatibility Antigens / Q000502:physiology; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2; D017493:Leukocyte Common Antigens