title: Polyamine sensitization in offshore workers handling drilling muds.
abstract: Oil-based mud, a complex mixture containing amines in emulsifiers, is used in offshore drilling operations. It is a skin irritant that occasionally gives rise to allergic contact sensitivity. In patch testing patients with allergy to drilling mud, we have identified polyamine (diethylenetriamine and triethylenetetramine) sensitivity in 5 patients. All 5 patients were also allergic to emulsifiers. These emulsifiers are cross-linked fatty acid amido-amines, in which unreacted amine groups are thought to cross-sensitize with these constituent polyamines. Cross-reactivity between ethylenediamine, diethylenetetramine and triethylenetetramine was found in 9 subjects.
authors.affiliation: Dermatology Department, Aberdeen Royal Infirmary, Foresterhill, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Ormerod
authors.forename: R A
authors.initials: RA
authors.lastname: Wakeel
authors.forename: T A
authors.initials: TA
authors.lastname: Mann
authors.forename: R A
authors.initials: RA
authors.lastname: Main
authors.forename: R D
authors.initials: RD
authors.lastname: Aldridge
mesh_terms: D000328:Adult; D002617:Chemical Industry; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D004655:Emulsions / Q000009:adverse effects*; D005029:Ethylenediamines / Q000009:adverse effects; D006801:Humans; D008153:Lubrication; D008297:Male; D008875:Middle Aged; D008899:Mineral Oil / Q000009:adverse effects; D010578:Petroleum; D011073:Polyamines / Q000009:adverse effects*; D014266:Trientine / Q000009:adverse effects
chemical_list: D004655:Emulsions; D005029:Ethylenediamines; D010578:Petroleum; D011073:Polyamines; C005391:diethylenetriamine; C031234:ethylenediamine; D008899:Mineral Oil; D014266:Trientine