[Vascular risk of oral contraceptive agents: realities and mechanisms. II. Mechanisms of vascular accidents: their prevention].
The mechanism of the vascular complications related to oral contraception is still unclear. In the present paper are discussed: (a) the possibility of accelerated atherosclerosis, suggested by the presence of a number of risk factors, a hypothesis which is not confirmed by pathological findings; (b) the possibility of a coagulation disease leading to thrombosis; (c) the arguments in favor of an immunological mechanism. This hypothesis is supported by the strong correlation between vascular complications and presence of antibodies against the synthetic hormones contained in the drug. It is also consistent with the aspect of the lesions, which might be induced by circulating immune complexes and antibodies. It is proposed that women at risk should be detected by systematic determination of antiethinylestradiol antibodies.
Beaumont
V
V
INSERM U32, Hôpital Henri Mondor, Créteil.
Beaumont
J L
JL
D000328:Adult; D000367:Age Factors; D000906:Antibodies / Q000032:analysis; D001161:Arteriosclerosis / Q000139:chemically induced; D001777:Blood Coagulation / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D003276:Contraceptives, Oral / Q000009:adverse effects* / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000276:immunology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008055:Lipids / Q000097:blood; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D000906:Antibodies; D003276:Contraceptives, Oral; D008055:Lipids; D004997:Ethinyl Estradiol
Le risque vasculaire des contraceptifs oraux: réalité et mécanisme. II. Mécanisme des accidents vasculaires: leur prévention.