Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis.
1. Plasma concentrations of acitretin and its metabolite (13-cis acitretin) were measured in six patients on haemodialysis and six subjects without renal failure following a single oral dose of 50 mg of acitretin. 2. The mean areas under the plasma concentration vs time curves of acitretin and its metabolite were about 50% lower in patients on haemodialysis. 3. No retinoids were detectable in the dialysate.
Stuck
A E
AE
Medizinische Universitätspoliklinik, Bern, Switzerland.
Brindley
C J
CJ
Busslinger
A
A
Frey
F J
FJ
D017255:Acitretin; D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D014212:Tretinoin; D017255:Acitretin