Local effects of PAF in guinea-pig inner ear.
The effect of PAF-containing artificial perilymph at 10(-7) and 10(-8) M on the endocochlear potential (EP) was investigated in guinea-pigs. The inner ear was perfused and the EP recorded at the same time. The characteristic decline of the EP which is highly sensitive to all stimuli could be prevented by pretreating the animals with either ginkgolide B (BN 52,021) or BM 13,177 (Sulotraban). Less effective in preventing the EP decline was Daltroban (BM 13,505). The results are discussed with respect to an involvement of PAF in cochlear physiology and in the regulation of ion transport, respectively.
Ernst
A
A
Department of Otolaryngology, Martin Luther University, Halle, G.D.R.
Syka
J
J
Riedel
A
A
Mest
H J
HJ
D000818:Animals; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004224:Diterpenes; D007758:Ear, Inner / Q000187:drug effects* / Q000502:physiology; D005260:Female; D046934:Ginkgolides; D006168:Guinea Pigs; D007783:Lactones / Q000494:pharmacology; D008297:Male; D010648:Phenylacetates / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors; D017482:Receptors, Thromboxane; D013449:Sulfonamides / Q000494:pharmacology
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010648:Phenylacetates; D010972:Platelet Activating Factor; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D013449:Sulfonamides; C040624:sulotroban; C045856:ginkgolide B; C051762:daltroban