Incidence and effects of herpes simplex virus infection after autologous bone marrow transplantation for solid tumours.
In a prospective study of 44 patients, who underwent autologous bone marrow transplantation (ABMT) for solid tumours, the results of serial viral cultures and determination of complement-fixing antibodies to herpes simplex virus (HSV) were analysed. No primary infections with HSV occurred. Of 31 initially HSV-seropositive ABMT patients, 61% developed positive HSV cultures. Half of these patients showed a significant antibody rise. Active HSV infection did not influence the recovery of the bone marrow after ABMT, but coincided with a significantly increased number of febrile days.
Mulder
P O
PO
Schröder
P
P
de Vries-Hospers
H G
HG
van der Geest
S
S
Sleijfer
D T
DT
Mulder
N H
NH
de Vries
E G
EG
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D011446:Prospective Studies; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification; D014182:Transplantation, Autologous