title: V beta-specific stimulation of human T cells by staphylococcal toxins.
abstract: The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.
authors.affiliation: Howard Hughes Medical Institute, Denver, CO.
authors.forename: J
authors.initials: J
authors.lastname: Kappler
authors.forename: B
authors.initials: B
authors.lastname: Kotzin
authors.forename: L
authors.initials: L
authors.lastname: Herron
authors.forename: E W
authors.initials: EW
authors.lastname: Gelfand
authors.forename: R D
authors.initials: RD
authors.lastname: Bigler
authors.forename: A
authors.initials: A
authors.lastname: Boylston
authors.forename: S
authors.initials: S
authors.lastname: Carrel
authors.forename: D N
authors.initials: DN
authors.lastname: Posnett
authors.forename: Y
authors.initials: Y
authors.lastname: Choi
authors.forename: P
authors.initials: P
authors.lastname: Marrack
mesh_terms: D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001427:Bacterial Toxins / Q000276:immunology / Q000494:pharmacology*; D017252:CD3 Complex; D016827:CD8 Antigens; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000276:immunology*; D013210:Staphylococcus; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte; D001427:Bacterial Toxins; D017252:CD3 Complex; D016827:CD8 Antigens; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell