title: [Mg2+ release from heart mitochondria in ischemia: is it the defense mechanism or damage?].
abstract: It is established that at the early stage of total heart ischemia in rats (5-10 min) the oligomycin-sensitive ATPase activity of mitochondria measured in heart homogenates in the medium and containing no Mg2+ decreases considerably, whereas the activity of respiratory chain, the value of respiratory control and Mg2+-ATPase activity are practically unchanged. The hypothetic trigger mechanism is suggested for Mg2+ ejection from mitochondria under conditions of respiration cessation. It is supposed to be a defence reaction of cells aimed to prevent ATP hydrolysis by mitochondria under ischemia.
authors.forename: V V
authors.initials: VV
authors.lastname: Lemeshko
authors.forename: P
authors.initials: P
authors.lastname: Malanda
mesh_terms: D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism*; D006706:Homeostasis; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D006180:Proton-Translocating ATPases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009840:Oligomycins; D017301:Ca(2+) Mg(2+)-ATPase; D006180:Proton-Translocating ATPases; D008274:Magnesium
vernacular_title: Vybros Mg2+ iz mitokhondriĭ serdtsa pri ishemii--mekhanizm zashchity ili povrezhdeniia?