title: Structural parts involved in activation and inactivation of the sodium channel.
abstract: Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.
authors.affiliation: Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Stühmer
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: X D
authors.initials: XD
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Noda
authors.forename: N
authors.initials: N
authors.lastname: Yahagi
authors.forename: H
authors.initials: H
authors.lastname: Kubo
authors.forename: S
authors.initials: S
authors.lastname: Numa
mesh_terms: D000200:Action Potentials; D000818:Animals; D004247:DNA; D009154:Mutation; D010063:Ovum; D010957:Plasmids; D015222:Sodium Channels; D013329:Structure-Activity Relationship; D014162:Transfection; D014981:Xenopus
chemical_list: D015222:Sodium Channels; D004247:DNA