Embryotoxicity and fetotoxicity of orally administered hexavalent chromium in mice.
The embryotoxic and fetotoxic potential of hexavalent chromium (Cr+6) in mice was investigated by administering 250, 500, and 1000 ppm of potassium dichromate daily through drinking water during the entire gestation period. An increase in embryonic deaths was observed; however, in the mothers treated with the highest dose, there was complete absence of implantation sites. No major abnormality was observed in the fetuses except that Cr+6 exposure increased the incidences and types of external and skeletal malformations. It is concluded that oral exposure to Cr+6 causes dose-dependent embryolethal effects in mice.
Trivedi
B
B
Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Saxena
D K
DK
Murthy
R C
RC
Chandra
S V
SV
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced / Q000473:pathology; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011192:Potassium Dichromate / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy
D011192:Potassium Dichromate