[Clinical signification of localization of S protein and late components in the skin from lupus patients].
We studied frozen tissue of lesional skin and normal-appearing skin from SLE patients and DLE patients by immunofluorescence. S-protein and late components (C5, C7, C9) were localized at the dermal-epidermal junction of the lesional skin from SLE and DLE patients. All specimens of normal-appearing skin from patients with SLE were free of deposits of S-protein and late components. These results suggest that late components may play a role in the development of skin lesions of SLE and DLE.
Ogawa
M
M
Hirakawa
T
T
Saida
Y
Y
Fujisawa
R
R
Ito
S
S
Sugisaki
T
T
D000328:Adult; D003182:Complement C5 / Q000032:analysis; D003184:Complement C7 / Q000032:analysis; D003186:Complement C9 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017293:Protein S; D012867:Skin / Q000032:analysis*
D003182:Complement C5; D003184:Complement C7; D003186:Complement C9; D006023:Glycoproteins; D017293:Protein S; D003165:Complement System Proteins