The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat.
The 5-HT2 receptor antagonist ritanserin (0.63 mg/kg IP) produced differential effects on sleep-wakefulness patterns in rats when administered during the light or dark period: an increase in the duration of deep slow wave sleep at the expense of light slow wave sleep, paradoxical sleep and wakefulness when injected during the light period, and no major sleep alteration when given at dark onset. Since circadian variations in serotonin receptor density might modulate the sleep response, we examined the effects of ritanserin on sleep in rats exposed to continuous light for 10 days, and whether 5-HT2 receptors were affected in separate groups of rats exposed to similar conditions. No significant changes in the KD- and Bmax -values of various receptors were found. However, ritanserin produced greater effects in continuous light conditions than when given during the light period in the 12-hr light-dark condition. This suggests a possible role of 5-HT2 receptors in the organization of sleep when the environmental photoperiod is disturbed.
Dugovic
C
C
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Leysen
J E
JE
Janssen
P F
PF
Wauquier
A
A
D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology*; D016713:Ritanserin; D012702:Serotonin Antagonists; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016713:Ritanserin