The renal effects of atrial natriuretic peptide in man are not attenuated by (+)-sulpiride.
1. Human alpha atrial natriuretic peptide (ANP) was infused intravenously for 1 h in eight healthy salt-replete men on two occasions, with and without pretreatment with (+)-sulpiride. 2. ANP increased sodium excretion and urine flow rate but did not alter blood pressure or plasma renin activity. 3. (+)-sulpiride had no significant effect on baseline creatinine clearance, sodium excretion or urine flow rate and did not alter the increases in these parameters with ANP. 4. It is unlikely that the renal effects of ANP are mediated by dopamine DA1-receptors in man.
Freestone
S
S
University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh.
MacDonald
T M
TM
Jeffrey
R F
RF
Brown
J
J
Lee
M R
MR
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000652:urine; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D012083:Renin / Q000097:blood; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013469:Sulpiride; D009320:Atrial Natriuretic Factor; D012083:Renin; D004298:Dopamine