Morphea after bromocriptine therapy.
A 57-year-old man developed morphea while taking bromocriptine. This drug is a semisynthetic ergot alkaloid, one of a class of drugs that is associated with fibrotic disorders. Other agents known for such association are serotonin (5-hydroxytryptamine) and beta-adrenergic blockers. A common pathogenesis to link these agents to fibrosis remains uncertain.
Leshin
B
B
Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Piette
W W
WW
Caplan
R M
RM
D001706:Biopsy; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology
D001971:Bromocriptine