title: Sequential hormonal therapy and sequential hormonal and chemotherapy for advanced prostatic cancer.
abstract: Ninety-two patients with D2 prostatic cancer were studied. Initial treatment was with either diethylstilboestrol (DES) or orchidectomy. Response to DES (5/63, 81%) was significantly higher than for orchidectomy (18/29, 62%; p less than 0.01). However, duration of response and duration of survival were not significantly different for the 2 forms of hormonal therapy. Fifty-seven patients were randomised to receive second-line treatment with either medroxyprogesterone acetate (MPA), oral chlorambucil or combination chemotherapy (adriamycin + cyclophosphamide + 5-fluoro-uracil). Response to second-line treatment was similar for all 3 regimens (46% overall response). Most of the responses were disease stabilisation and, although there was symptomatic benefit, response to second-line therapy did not significantly improve survival compared to the survival experience of the group as a whole. It is concluded that palliative second-line treatment for advanced prostatic cancer should consist of the least toxic form of treatment which in this study was second-line hormone administration (MPA).
authors.affiliation: Department of Medicine, Hillbrow Hospital, Johannesburg, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Ruff
authors.forename: D P
authors.initials: DP
authors.lastname: Derman
authors.forename: A
authors.initials: A
authors.lastname: Weaving
authors.forename: W R
authors.initials: WR
authors.lastname: Bezwoda
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002699:Chlorambucil / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004054:Diethylstilbestrol / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013997:Time Factors
chemical_list: D002699:Chlorambucil; D004054:Diethylstilbestrol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone