Adrenal suppression after corticosteroid injection of periocular hemangiomas.
Two infants with symptomatic periocular hemangiomas received 1-ml intralesional injections of a 50:50 mixture of triamcinolone acetonide (40 mg/ml) and betamethasone (8 mg/ml). Both developed adrenal suppression as evidenced by the immediate depression of their serum cortisol and adrenocorticotrophic hormone levels. One patient remained adrenal suppressed for five months and, concurrently, her growth rate and weight dropped from normal to below the fifth percentile. Adrenal suppression should be added to the growing list of complications caused by the corticosteroid injection of periocular hemangiomas.
Weiss
A H
AH
Department of Ophthalmology, University of South Florida Medical Center, Tampa 33612.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects; D001763:Blepharoptosis / Q000209:etiology; D003864:Depression, Chemical; D004359:Drug Therapy, Combination; D005142:Eyelid Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006391:Hemangioma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007223:Infant; D009918:Orbital Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D001623:Betamethasone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone