[Renal cortex ischemia, right atrial thrombosis and coronary occlusion in anti-phospholipid antibody syndrome].
The presence of a lupus anticoagulant (LA) is paradoxically associated with a high incidence of arterial and venous thrombosis. In a patient with a lupus-like systemic disease, having received phenindione for 11 years, LA was discovered in association with recurrent deep venous thrombosis, a right atrial thrombus, coronary occlusion, arterial hypertension, thrombopenia, and anticardiolipin antibodies without anti-DNA antibodies. Renal cortical ischemia was detected by a tomographic scan. Renal biopsy showed glomerular ischemia and diffuse interstitial fibrosis. After a one-year anticoagulant and steroid therapy, LA has disappeared despite a high level of anticardiolipin antibodies, and renal function remains normal.
Ramdane
M
M
Service de Néphrologie, CHI de Montreuil.
Gryman
R
R
Bacques
O
O
Callard
P
P
Kleinknecht
D
D
D001323:Autoantibodies / Q000032:analysis / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology*; D003327:Coronary Disease / Q000209:etiology; D006325:Heart Atria; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007672:Kidney Cortex / Q000098:blood supply* / Q000473:pathology; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D013924:Thrombophlebitis / Q000209:etiology; D013927:Thrombosis / Q000209:etiology*
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor
Ischémie rénale corticale, thrombose auriculaire droite et occlusion coronaire au cours d'un syndrome des anticorps antiphospholipides.