Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation.
Cells respond to many hormones, neurotransmitters and growth factors by increasing intracellular Ca2+. This second messenger, in turn, affects cellular function via activation of a novel multifunctional Ca2+/calmodulin-dependent protein kinase. The kinase displays an interesting form of biochemical 'memory'; activation elicits an autophosphorylation which converts it to a Ca2+-independent enzyme that can continue to phosphorylate cellular proteins for some time following termination of the initial Ca2+ stimulus.
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D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000378:metabolism; D011494:Protein Kinases; D051381:Rats
D009097:Multienzyme Complexes; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases