Amplification of nocturnal oscillations in PRA and aldosterone during continuous heat exposure.
To assess the effect of continuous heat exposure on the nocturnal patterns of renin, aldosterone, adrenocorticotropic hormone (ACTH), and cortisol, six young men were exposed to thermoneutral environment for 5 days, followed by a 5-day acclimation period in a hot dry environment (35 degrees C). Blood was collected at 10-min intervals during the second night at thermoneutrality (N0) and during the first (N1) and the last (N5) nights of heat exposure. Polygraphic recordings of sleep were scored according to established criteria. Continuous heat exposure led to progressive decreases in the 24-h urinary volume and in Na excretion, whereas urinary osmolality increased. After 5 days of uninterrupted heat, significant increases were found in plasma volume (P less than 0.05), osmolality (P less than 0.01), plasma Na (P less than 0.01), and protein levels (P less than 0.05). Sweat gland output increased during the first 3 days and then declined without any concomitant increases in body temperature. Compared with N0, there were no differences in plasma renin activity (PRA) and aldosterone (PA) profiles during N1 at 35 degrees C. However, during N5 the mean PRA and PA levels were significantly (P less than 0.05) enhanced, and their nocturnal oscillations were amplified (P less than 0.05). This amplification occurred mainly in the second part of the night when regular rapid-eye-movement and non-rapid-eye-movement sleep cycles were observed, leading to a general upward trend in the nocturnal profiles. The relationship between the nocturnal PRA oscillations and the sleep cycles was not modified. ACTH and cortisol patterns were not affected by continuous heat exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
Brandenberger
G
G
UMR 32, Centre National de la Recherche Scientifique, Institut National de Recherche et de Sécurité, Strasbourg, France.
Follenius
M
M
Di Nisi
J
J
Libert
J P
JP
Simon
C
C
D000064:Acclimatization; D000204:Activity Cycles; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D001831:Body Temperature; D002940:Circadian Rhythm; D006400:Hematocrit; D006358:Hot Temperature; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood; D013546:Sweating
D001798:Blood Proteins; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium; D006854:Hydrocortisone