[Pharmacokinetics of cefixime in healthy volunteers after a single oral administration of 200 mg].
The antibacterial activity of cefixime is identical with that of parenteral third generation cephalosporins. Its kinetics were studied in 24 healthy male volunteers who received one single 200 mg tablet. Cmax was 3.25 mg/l and Tmax was 4 h. After 12 hours, serum concentrations were still as high as 0.70 mg/l. Half-life was 3.3 h and urinary excretion was not predominant. Thus, cefixime was characterized by its relatively long serum half-life as compared with other cephalosporins. Despite some degree of individual variations, serum and urine concentrations of the antibiotic remained for 12 hours above the MIC of susceptible pathogens.
Montay
G
G
Rhóne-Poulenc Santé, Institut de Biopharmacie, Antony.
Le Liboux
A
A
Thebault
J J
JJ
Roche
G
G
Frydman
A
A
Gaillot
J
J
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors
D020682:Cefixime; D002439:Cefotaxime
Pharmacocinétique du céfixime chez le volontaire sain après administration orale unique à la dose de 200 mg.