title: Acute poisoning treated in the intensive care unit: a case series.
abstract: A retrospective study on patients with acute poisoning admitted to the Intensive Care Unit (ICU) of the Ichilov Hospital over a 3-year period (1982-84) is presented. Of 419 patients seen in the Emergency Room for intoxication during these years, 71 (17%) required intensive care upon admission. Suicide attempts accounted for 90% of the ICU admissions, with drugs of the benzodiazepine (BDZ) group being the most commonly used (51%). Mixed-drug overdose was seen in 55% of the patients. There was a poor correlation between the drugs suspected on admission and those actually detected in the blood. Although the total number of admissions due to poisoning increased in 1984 (21 in 1982 vs. 37 in 1984), mechanical ventilation was required by fewer patients (92% in 1982 vs. 51% in 1984) and for a shorter period of time (3.1 days in 1982 vs. 2.1 days in 1984), which resulted in a shorter ICU stay (4.8 days in 1982 vs. 3.1 days in 1984). The introduction of the new BDZ antagonist flumazenil may have partially accounted for this positive trend.
authors.affiliation: Department of Anesthesiology and Intensive Care, Ichilov Hospital, Tel Aviv Medical Center, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Leykin
authors.forename: P
authors.initials: P
authors.lastname: Halpern
authors.forename: A
authors.initials: A
authors.lastname: Silbiger
authors.forename: P
authors.initials: P
authors.lastname: Sorkin
authors.forename: D
authors.initials: D
authors.lastname: Niv
authors.forename: V
authors.initials: V
authors.lastname: Rudick
authors.forename: E
authors.initials: E
authors.lastname: Geller
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications; D008875:Middle Aged; D011041:Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy*; D011963:Receptors, GABA-A / Q000187:drug effects; D012189:Retrospective Studies; D013406:Suicide, Attempted
chemical_list: D011963:Receptors, GABA-A; D005442:Flumazenil