Beta-thioglucose inhibits gold thioglucose lesions in the ventromedial hypothalamus.
Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabolite, on GTG-induced lesions in the VMH of mice. Twenty-eight female CF-1 mice were used in this study. Seven micron sections were made of the mouse VMH, mounted on glass slides, and stained with hematoxylin and eosin. A previous report of BTG action on GTG-induced lesions has not supported a competitive inhibition between these two drugs. Our data demonstrate that at 1/2 hour, 6 hours, and 12 hours post BTG, BTG completely inhibited GTG-induced lesions in the VMH.
Brown
D F
DF
Department of Anatomy, University of Health Sciences, College of Osteopathic Medicine, Kansas City, MO 64124.
McGuirk
J P
JP
Larsen
S P
SP
Minter
S D
SD
D000818:Animals; D006051:Aurothioglucose / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006046:Gold / Q000009:adverse effects*; D051379:Mice; D013997:Time Factors; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects* / Q000473:pathology
D006051:Aurothioglucose; D006046:Gold; C018399:1-thioglucose; D005947:Glucose