Studies on peripheral T lymphocyte subsets in patients with autoimmune thyroid diseases.
Peripheral T lymphocyte subsets in 60 cases of Graves' disease (GD) and 16 cases of Hashimoto's thyroiditis (HT) were determined by the use of OKT monoclonal antibodies (McAb). The results showed that in both diseases OKT3 cells (total T cells) and OKT8 cells (suppressor T cells, TS cells) were lower and the ratio of OKT4 cells (helper T cells, TH cells) OKT8 cells was much higher than those in normal controls. GD patients who were treated with antithyroid drugs (ATD) and whose serum T3, T4 recovered to normal, could be further divided into subgroups of high OKT4/OKT8 cell ratio and of normal ratio. The pathogenesis, treatment and relapse of autoimmune thyroid diseases (AITD) were discussed in this paper on the basis of the results.
Chen
G
G
Zhang
K Z
KZ
Liao
Z H
ZH
Wang
S H
SH
Ma
S J
SJ
Long
Z Z
ZZ
Tian
W T
WT
Zhu
J Y
JY
D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000911:Antibodies, Monoclonal; D014284:Triiodothyronine; D013974:Thyroxine