Influenza virus-specific T cells lead to early interferon gamma in lungs of infected hosts: development of a sensitive radioimmunoassay.
A sensitive immunoradiometric assay for murine interferon gamma (MuIFN-gamma) has been developed and used reproducibly to measure low levels of MuIFN-gamma in lung lavage samples from influenza-infected mice. In control infected mice, IFN-gamma peaked on day 6, but transfer of virus-specific cytotoxic T cells or T helper cells, which reduced virus replication in vivo in infected hosts, resulted in an earlier peak on day 4.
Taylor
P M
PM
Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, U.K.
Meager
A
A
Askonas
B A
BA
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D007371:Interferon-gamma / Q000032:analysis*; D008168:Lung / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011863:Radioimmunoassay; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D007371:Interferon-gamma