title: [Efficacy and tolerance of tiaprofenic acid in pharyngitis in adults. Results of a randomized study vs placebo].
abstract: Tiaprofenic acid (Surgam) is a non steroidal anti-inflammatory drug used in France for the treatment of acute inflammation, during episodes of upper respiratory tract infections of children and adults. The efficacy and tolerance of tiaprofenic acid for the treatment of inflammation during adult tonsillitis and pharyngitis were evaluated by a randomized double-blind study versus placebo. We used evaluation criterion taking into consideration dysphagia and inflammatory physical indications of tonsillitis and opinions of investigators and patients. Sixty patients have been included in this study. They received either tiaprofenic acid or placebo during five days together with penicillin V. After 48 hours and 5 days of treatment, the efficacy of tiaprofenic acid was significantly superior to placebo on all principal test studied. Tolerance was good in both groups.
authors.affiliation: Laboratoires Roussel, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Benarrosh
authors.forename: A
authors.initials: A
authors.lastname: Ulmann
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy*; D010919:Placebos; D011422:Propionates / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D011422:Propionates; C021270:tiaprofenic acid
vernacular_title: Efficacité et tolérance de l'acide tiaprofénique dans les angines de l'adulte. Résultats d'une étude randomisée contre placebo.