Nucleotide sequence of the Marek's disease virus (MDV) RB-1B A antigen gene and the identification of the MDV A antigen as the herpes simplex virus-1 glycoprotein C homologue.
The A antigen gene from a very virulent strain of Marek's disease virus, RB-1B, has been cloned and the nucleotide sequence determined. The predicted amino acid sequence showed 99% identity to that determined for the MDV GA A antigen (Coussens and Velicer, J. Virol. 62, 2373-2379, 1988) over all but the carboxy-terminal region where the sequence diverged extensively. The divergence results from three nucleotide frameshifts in the reported sequence of the MDV GA gene which are not present in a cloned copy of the MDV GA A antigen gene sequenced by us. The MDV A antigen shows significant homology to a number of herpes virus gC homologues, the homology being most extensive in the carboxy-halves of the proteins.
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AFRC Institute for Animal Health, Houghton Laboratory, Cambridgeshire, U.K.
Ross
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D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D001483:Base Sequence; D002478:Cells, Cultured; D002642:Chick Embryo; D005796:Genes; D005814:Genes, Viral; D006564:Herpesviridae / Q000235:genetics; D008381:Herpesvirus 2, Gallid / Q000235:genetics*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014759:Viral Envelope Proteins / Q000235:genetics
D000956:Antigens, Viral; C056151:Marek's disease herpesvirus gp57-65; D012333:RNA, Messenger; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C038535:glycoprotein gC, herpes simplex virus type 1