title: Polymerization of a monomeric guanosine derivative in a hydrogen- bonded aggregate.
abstract: The adduct IIa, in which glycine is linked to the 3'-amino group of 3'-deoxyguanosine-5'-phosphate, condenses very efficiently in aqueous solution when treated with a water-soluble carbodiimide to give long oligomeric products. The corresponding cytidine derivative IIb yields a complex mixture of very short oligomers. We believe that the efficient condensation reaction occurs in a hydrogen-bonded tetrahelical aggregate of a type that is known to form with many guanosine derivatives.
authors.affiliation: The Salk Institute for Biological Studies, San Diego, California 92138
authors.forename: W S
authors.initials: WS
authors.lastname: Zielinski
authors.forename: L E
authors.initials: LE
authors.lastname: Orgel
mesh_terms: D000596:Amino Acids; D002234:Carbodiimides / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006151:Guanosine / Q000031:analogs & derivatives*; D011108:Polymers
chemical_list: D000596:Amino Acids; D002234:Carbodiimides; D011108:Polymers; D006151:Guanosine