Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions.
Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.
Kloog
Y
Y
Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Ambar
I
I
Kochva
E
E
Wollberg
Z
Z
Bdolah
A
A
Sokolovsky
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D018000:Receptors, Peptide; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014757:Viper Venoms / Q000494:pharmacology*
D010716:Phosphatidylinositols; D011950:Receptors, Cholinergic; D018000:Receptors, Peptide; D014662:Vasoconstrictor Agents; D014757:Viper Venoms; C058085:sarafotoxin receptor; C057354:sarafotoxins s6; D002118:Calcium