[Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
The intrahippocampal injection of two agonists of excitatory aminoacid (EAA) receptors elicited neuronal damages localized in CA1 and dentate gyrus for N-methyl-D-aspartate (NMDA) (20 nmol) and extended to the various hippocampal areas, except dentate gyrus for kainic acid (KA) (2.5 nmol). The pretreatment of the animals with N-[1-(2-thienyl)cyclohexyl]piperidine (TCP) (20 mg/kg), a noncompetitive NMDA-receptor antagonist, prevented the neuronal injury induced by NMDA and KA in CA1. The distribution of neuronal damages and of TCP-protected areas closely correlated to that of EEA-receptors and of TCP binding sites in the hippocampus.
Belaidi
M
M
Laboratoire de Médecine Expérimentale, Institut de Biologie, Montpellier.
Rondouin
G
G
Lerner-Natoli
M
M
N'Gouemo
P
P
Kamenka
J M
JM
D000818:Animals; D001224:Aspartic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000293:injuries; D013287:Illicit Drugs / Q000009:adverse effects; D007608:Kainic Acid / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D010622:Phencyclidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D013287:Illicit Drugs; D001224:Aspartic Acid; D016202:N-Methylaspartate; C012058:tenocyclidine; D010622:Phencyclidine; D007608:Kainic Acid
Lésions excitotoxiques de l'hippocampe chez le rat: implication des récepteurs au N-méthyl-D-aspartate.