[The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits].
Measurements of penicillin concentrations in the blood sera and tissues of rabbits have revealed a reduction of this antibiotic levels as the doses of injected ascorbic acid grew. A combination of benzylpenicillin with ascorbic and nicotinic acids improved penicillin penetration into experimental animals' tissues.
Bednova
V N
VN
Rotanov
S V
SV
Navolotskaia
T I
TI
Milonova
T I
TI
Orlina
E A
EA
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D009525:Niacin / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D010400:Penicillin G / Q000032:analysis / Q000493:pharmacokinetics*; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D009536:Niacinamide; D009525:Niacin; D001205:Ascorbic Acid; D010400:Penicillin G
Vliianie nikotinamida, nikotinovoĭ i askorbinovoĭ kislot na kontsentratsiiu penitsillina v syvorotke krovi i tkaniakh krolikov.