Dermorphin inhibits micturition reflex in rats at a central site of action.
Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued. These effects of dermorphin or DADLE were promptly abolished by i.v. naloxone (0.2 mg/kg). The inhibitory effect of dermorphin but not that of DADLE was partially prevented by systemic capsaicin desensitization (50 mg/kg s.c., 4 days before). Intravenous dermorphin had little or no effect on micturition up to 8 micrograms/kg.
Maggi
C A
CA
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Giuliani
S
S
Meli
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine; D007278:Injections, Spinal; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D014554:Urination / Q000187:drug effects*
D009842:Oligopeptides; D018847:Opioid Peptides; D011957:Receptors, Opioid; C030058:dermorphin; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine