[Does determination of atrial natriuretic factor have significance in the assessment of cardiac stress in apnea in sleep apnea patients?].
It has long been known that the heart is involved volume regulation. This fact took on new importance when, in 1981, de Bold discovered the existence of ANF. Apnea-associated cardiovascular changes make the treatment of apnea necessary to prevent the occurrence of cardiovascular sequelae. What is needed, however, is a parameter which, non-invasively, reflects both the cardiac loading during apnea and effects of treatment. Krieger succeeded in demonstrating that the commonly observed nycturia regresses under nasal cPAP therapy. This prompted us to consider whether the ANF factor might not be involved. In an attempt to find an answer, we have, up to now, investigated six patients prior to and during nCPAP therapy. On the basis of the results we obtained, the following conclusions may be drawn: 1. During apnea, the patients show sometimes dramatic increases in ANF plasma levels. 2. Under nasal CPAP treatment, these elevated levels decrease again, in some cases by as much as 50%. 3. The ANF plasma level correlates with pulmonary arterial pressure. This suggests to us that ANF determination is of importance for the assessment of cardiac loading during apnea, and represents a parameter that reflects the effects of therapy.
Ehlenz
K
K
Schmidt
P
P
Becker
H
H
Podszus
T
T
Peter
J H
JH
Kaffarnik
H
H
von Wichert
P
P
D009320:Atrial Natriuretic Factor / Q000097:blood*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000097:blood*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000097:blood*
D009320:Atrial Natriuretic Factor
Hat die Bestimmung des atrialen natriuretischen Faktors (ANF) eine Bedeutung in der Beurteilung der kardialen Belastung während der Apnoe bei Schlafapnoe-Patienten?