A synthetic decapeptide analogue of human seminal plasma inhibin exhibiting specific suppression of follicle stimulating hormone release in rats.
Synthesis and biological profile of a decapeptide analogue, [Tyr85, Cys(Acm)87]85-94 of human seminal plasma inhibin (HSPI) are described. The peptide suppressed the circulatory levels of follicle stimulating hormone (FSH) in adult male rats. No change in the levels of luteinizing hormone (LH) and prolactin (Prl) was observed. Whereas the peptide suppressed the release of both FSH and LH in vitro. This decapeptide is the smallest peptide reported so far to have FSH suppressing activity.
Iyer
K S
KS
Mahale
S D
SD
Hurkadli
K S
KS
Sheth
A R
AR
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007265:Inhibins / Q000031:analogs & derivatives* / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments; D011388:Prolactin / Q000378:metabolism; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D029589:Seminal Plasma Proteins
D010446:Peptide Fragments; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; C062301:seminal plasma inhibin (85-94), Tyr(85), Cys(Acm)(87)-; D007265:Inhibins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone