title: Role of zinc in regulating the testicular function. Part 2. Effect of dietary zinc deficiency on gonadotropins, prolactin and testosterone levels as well as 3 beta-hydroxysteroid dehydrogenase activity in testes of male albino rats.
abstract: Induced zinc deficiency in male albino rats caused a great reduction in the testicular levels of testosterone as compared to control and zinc-supplemented (ZS) rats. Estimation of the testicular levels of follicle-stimulating hormone, luteinizing hormone and prolactin (PRL) in the zinc-deficient (ZD) rats showed higher levels in comparison with both control and zinc-supplemented rats. However, the increase in PRL levels was statistically insignificant. A great reduction in the activity of 3 beta-hydroxysteroid dehydrogenase, an important enzyme involved in testosterone biosynthesis, was demonstrated histochemically in the testes of ZD rats as compared to both control and ZS ones. These results reflect a direct action of zinc deficiency on the testicular steroidogenesis and strongly support the idea that the hypogonadal state associated with zinc deficiency results mainly from some alteration in the testicular steroidogenesis or in other words Leydig cell failure.
authors.affiliation: National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Mansour
authors.forename: A A
authors.initials: AA
authors.lastname: Hafiez
authors.forename: Z H
authors.initials: ZH
authors.lastname: el-Kirdassy
authors.forename: M N
authors.initials: MN
authors.lastname: el-Malkh
authors.forename: F A
authors.initials: FA
authors.lastname: Halawa
authors.forename: E M
authors.initials: EM
authors.lastname: el-Zayat
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000032:analysis*; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000032:analysis; D006651:Histocytochemistry; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D011388:Prolactin / Q000032:analysis; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D013739:Testosterone / Q000032:analysis; D015032:Zinc / Q000172:deficiency / Q000502:physiology*
chemical_list: D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015096:3-Hydroxysteroid Dehydrogenases; D015032:Zinc