[Intracellular electrolytes and selected biochemical parameters in patients with borderline arterial hypertension and positive family history of hypertension].
The studies involved 22 patients with borderline hypertension and familial history of the arterial blood hypertension (mean age 24.6 years) and 9 patients without familial history of hypertension (mean age 22.2 years). Control group included 10 healthy volunteers (mean age 27.5 years). Erythrocyte Na+ and K+ levels, daily secretion of noradrenaline (NA), adrenaline (A) and dopamine (DA), prostacyclin metabolite 6-keto-PGF1 alpha, beta-thromboglobulin levels (beta-TG), triglyceride cholesterol, and HDL-cholesterol were determined in all examined subjects. Friedewald's equation was used to calculate LDL-cholesterol. Moreover, LCAT activity was measured. An increase in erythrocyte Na+, increased sympathetic activity, excessive platelet activity and decreased 6-keto-PGF1 alpha levels were found in the group of hypertensive patients with familial history of the arterial blood hypertension. HDL-cholesterol was significantly lower in these patients than in the control group. Atherogenic index (cholesterol/HDL-cholesterol ratio) was the highest in the hypertensive patients with familial history of the arterial blood hypertension. The difference was insignificant, however. Patients with the borderline hypertension and familial predisposition to this disease differ from the hypertensive patients without familial history of the arterial hypertension in humoral profile suggesting a contribution of the genetic factors to the development of the arterial blood hypertension.
Wocial
B
B
Grzesiuk
W
W
Kuczyńska
K
K
Berent
H
H
Ignatowska-Switalska
H
H
Lapiński
M
M
Młyński
J
J
Jabłońska-Skwiecińska
E
E
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D002395:Catecholamines / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis
D002395:Catecholamines; D008055:Lipids; D001620:beta-Thromboglobulin; D015121:6-Ketoprostaglandin F1 alpha; D012964:Sodium; D011188:Potassium
Elektrolity wewnatrzkomórkowe i wybrane parametry biochemiczne u chorych na nadciśnienie tetnicze graniczne i z dodatnim wywiadem rodzinnym w kierunku nadciśnienia.