[The effect of pharmacologic blockade of serotonin receptors (S2) on arterial pressure in rats with 2 forms of hereditary arterial hypertension].
The influence of blockade of serotonin S2 receptors with ketanserin was studied in two strains of rats with inherited arterial hypertension: spontaneously hypertensive rats (SHR strain) and rats with inherited stress-induced arterial hypertension (ISIAH strain). It was found that peripheral injection of ketanserin produced a greater decrease of arterial blood pressure than i.c.v. administration. ISIAH rats were more sensitive to the hypotensive effect of ketanserin when compared to normotensive Wistar or SHR rats.
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D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D007650:Ketanserin / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D016713:Ritanserin; D013315:Stress, Psychological / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology
D000959:Antihypertensive Agents; D010880:Piperidines; D011985:Receptors, Serotonin; D016713:Ritanserin; D007650:Ketanserin
Vliianie farmakologicheskoĭ blokady serotoninovykh (S2) retseptorov na arterial'noe davlenie u krys s dvumia formami nasledstvennoĭ arterial'noĭ gipertenzii.