Human IgE-binding factors.
The production of IgE antibodies is known to be regulated by isotype-specific mechanisms that are not antigen specific. During the last decade several studies have indicated that soluble factors with affinity for IgE (IgE-binding factors, IgE-BFs) may exert such a role by interacting with IgE-bearing B lymphocytes. In the human, some of these IgE-BFs appear to be identical to soluble CD23, a B-cell surface marker thought to be involved in the control of B-cell proliferation or differentiation. In this article, Guy Delespesse and colleagues summarize several new findings regarding the cellular origin, structure and function of IgE-BFs/sCD23.
Delespesse
G
G
Sarfati
M
M
Hofstetter
H
H
D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D008222:Lymphokines / Q000032:analysis / Q000502:physiology*; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000235:genetics / Q000502:physiology; D017455:Receptors, IgE
D000944:Antigens, Differentiation, B-Lymphocyte; D007378:Interleukins; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017455:Receptors, IgE; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D015847:Interleukin-4; D007073:Immunoglobulin E