Elevated blood viscosity in alloxan diabetic dogs and experimentally galactosemic dogs.
Blood viscosity was investigated in alloxan-diabetic dogs and in dogs made experimentally hyperglycemic by a galactose-rich diet. The diabetics were prospectively assigned to levels of glycemic control ranging from poor to good. After up to 5 years of study, the blood viscosity of hyperglycemic diabetic animals was significantly greater than normal at both high (100 sec-1) and low (0.1 sec-1) shear rates. Blood viscosity at the low shear rate correlated closely with fibrinogen concentration, (r = 0.75; p less than 0.02) but not with HbA1 concentration (r = 0.14) in the diabetics. Galactosemic animals likewise had elevated blood viscosity at the low shear rate, but the correlation of viscosity with fibrinogen concentration in those animals was not statistically significant (r = 0.42). Plasma viscosity tended to be elevated in both diabetes and galactosemia, but not to a statistically significant degree.
Kern
T S
TS
Department of Ophthalmology, University of Wisconsin, Madison 53706.
Engerman
R L
RL
Peterson
C M
CM
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004285:Dogs; D005340:Fibrinogen / Q000032:analysis; D005693:Galactosemias / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis; D012016:Reference Values
D001786:Blood Glucose; D001798:Blood Proteins; D005340:Fibrinogen; D006442:Glycated Hemoglobin