Is the conventional doctrine about macrophage activation still true?
The present results challenge the view that macrophage activation leads to a general, non-specific increase of microbicidal activity of these cells. Instead, it was found that the interactions between activated macrophages and micro-organisms are dependent on the kind of activation and the type of target micro-organism.
van Furth
R
R
University Hospital, Department of Infectious Diseases, Leiden, The Netherlands.
van Dissel
J T
JT
D000818:Animals; D001419:Bacteria / Q000276:immunology*; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008089:Listeria monocytogenes / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D012486:Salmonella typhimurium / Q000276:immunology