Comparative immunogenicity study of four plasma-derived hepatitis B vaccines in Thai young adults.
Immunogenicity of four plasma-derived hepatitis B vaccines (Merck, Sharp and Dohme, Pasteur, Dutch CLB and Korean Cheil-Sugar) was compared in Thai young adults. After primoimmunization, only the Merck and Pasteur vaccines could achieve greater than 90% seroconversion (i.e. anti-HBs greater than or equal to 10 mIU ml-1) whereas both the CLB and Korean vaccines needed a fourth dose to achieve this level of seroconversion. The anti-HBs titres of both heat-inactivated vaccines (CLB and Korean) were also significantly lower than those of the other two vaccines. We propose that the HBsAg content in both heat-inactivated vaccines should be increased and a booster (fourth) dose should be given in order to enhance their immunogenicities.
Phanuphak
P
P
Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
Phanpanich
T
T
Wongurai
S
S
Sirivichayakul
S
S
Sriwanthana
B
B
Panmuong
W
W
Utaisen
O
O
Chutivongse
S
S
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D017325:Hepatitis B Vaccines; D006801:Humans; D008297:Male; D013785:Thailand; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines