title: Increased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.
abstract: We investigated the possible relation between neuropeptides and cerebral vasoconstriction in samples of ventricular or cisternal cerebrospinal fluid from 14 patients with subarachnoid hemorrhage. Neuropeptide Y, calcitonin gene-related peptide, atrial natriuretic peptide, and pituitary polypeptide 7B2 were present in the cerebrospinal fluid of these patients. Concentrations of calcitonin gene-related peptide and 7B2 were not significantly different from those in control subjects, but that of atrial natriuretic peptide was significantly lower. Although the mean concentration of neuropeptide Y was not significantly higher than control, consecutive determinations showed an increase 6-11 days after the onset of subarachnoid hemorrhage. An initially high 7B2 concentration decreased gradually, although half the patients showed a second increase greater than 10 days after the onset. Considering the well-recognized vasoconstrictive effect of neuropeptide Y, it is possible that this increase in its concentration in the cerebrospinal fluid plays a role in the pathogenesis of the cerebral vasospasm that is often seen after subarachnoid hemorrhage.
authors.affiliation: Department of Endocrinology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Namba
authors.forename: R
authors.initials: R
authors.lastname: Ohtake
authors.forename: Y
authors.initials: Y
authors.lastname: Hashigami
authors.forename: S
authors.initials: S
authors.lastname: Suga
authors.forename: N
authors.initials: N
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Shimoda
mesh_terms: D000368:Aged; D009320:Atrial Natriuretic Factor / Q000134:cerebrospinal fluid; D015740:Calcitonin Gene-Related Peptide / Q000134:cerebrospinal fluid; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid / Q000150:complications; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid*; D009994:Osmolar Concentration; D010907:Pituitary Hormones / Q000134:cerebrospinal fluid; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000209:etiology; D013997:Time Factors
chemical_list: D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D009478:Neuropeptide Y; D010907:Pituitary Hormones; C497678:SCG5 protein, human; D009320:Atrial Natriuretic Factor; D015740:Calcitonin Gene-Related Peptide