Morphological response of mycoplasma to fleroxacin.
Quinolones exhibit partially reduced activity in vitro against genital mycoplasma. Therefore, the morphological response to fleroxacin, a difluorinated quinolone, by Mycoplasma hominis was studied. Even at subinhibitory concentrations the ultrastructural investigations revealed distinct alterations such as cytolysis, vacuole and cell "ghost" formation. The typical dumbbell-shaped cells observed with monofluorinated compounds were not found, which may indicate a qualitatively different mode of action.
Werk
R
R
Babende Institut, Würzburg, FR Germany.
Schneider
L
L
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016576:Fleroxacin; D006801:Humans; D009175:Mycoplasma Infections / Q000188:drug therapy* / Q000473:pathology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin