[Spectrophotometric determination of complex formation constants of naproxen with caffeine, nicotinamide and salicylic acid in aqueous solution].
The interaction between water insoluble drug naproxen with caffeine, nicotinamide and salicylic acid in aqueous solutions were determined by spectrophotometry. Naproxen was found to form 1:1 molecular complex with these substances. The complex formation constants were determined by spectrophotometry at room temperature. The thermodynamic functions associated with complexation of naproxen-drugs were also evaluated. It may be concluded that the complex formation may be attributed to hydrogen bonding since enthalpy changes were shown to be a few KJ.mol-1.
Shi
Q H
QH
Wang
J J
JJ
Liu
X D
XD
Zhang
J H
JH
D002110:Caffeine / Q000032:analysis; D008024:Ligands; D009288:Naproxen / Q000032:analysis*; D009536:Niacinamide / Q000032:analysis; D012459:Salicylates / Q000032:analysis; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D008024:Ligands; D012459:Salicylates; D012996:Solutions; D009536:Niacinamide; D002110:Caffeine; D009288:Naproxen