title: The effects of cimetidine on creatinine excretion, glomerular filtration rate and tubular function in renal transplant recipients.
abstract: The renal clearance of endogenous creatinine (CCr), sodium (CNa) and lithium (CLi) was determined before and after a single intravenous bolus of cimetidine in nine renal transplant recipients. The glomerular filtration rate (GFR) was measured with 125I-iothalamate clearance (CTh). The initial CCr of 65 ml/min (median) was reduced to a nadir of 46 ml/min (p less than 0.01) during the first 2 h after infusion of cimetidine. GFR remained unchanged, and thus the fractional clearance of creatinine (CCr/CTh) was reduced from 1.43 (median) to 1.03 (p less than 0.01). CNa and the fractional excretion of sodium decreased throughout the study (p less than 0.05); CLi was unchanged. In conclusion cimetidine, when measured during 1-h clearance periods, interferes with tubular creatinine secretion in the denervated kidney of transplant recipients without affecting the glomerular filtration rate or proximal tubular flow. This suggests that on-going cimetidine treatment must be taken into account when graft function is evaluated by the CCr alone.
authors.affiliation: Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: N V
authors.initials: NV
authors.lastname: Olsen
authors.forename: S D
authors.initials: SD
authors.lastname: Ladefoged
authors.forename: B
authors.initials: B
authors.lastname: Feldt-Rasmussen
authors.forename: N
authors.initials: N
authors.lastname: Fogh-Andersen
authors.forename: H
authors.initials: H
authors.lastname: Jordening
authors.forename: O
authors.initials: O
authors.lastname: Munck
mesh_terms: D000042:Absorption; D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000187:drug effects / Q000502:physiology*; D008094:Lithium / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism
chemical_list: D002927:Cimetidine; D008094:Lithium; D012964:Sodium; D003404:Creatinine