title: Effect of unilateral vesicoureteric reflux on renal growth and the uptake of 99mTc DMSA by the kidney. An experimental study in the minipig.
abstract: The influence of unilateral vesicoureteric reflux (VUR) on renal growth and the uptake of 99mTc DMSA by the kidney has been investigated in a 2-kidney model in the growing minipig over a period of approximately 5 months. Animals with reflux in association with low voiding pressures and normal bladder function (n = 5), as well as those with raised voiding pressures and abnormal bladder function (n = 7), were investigated with appropriate non-refluxing controls (n = 12). Urinary infection and renal scarring were avoided since these factors may affect kidney function and growth independently. Statistical tests of difference failed to demonstrate any effect of VUR on renal growth or renal uptake of 99mTc DMSA even in the presence of elevated voiding pressures and abnormal detrusor function.
authors.affiliation: Institute of Child Health, London.
authors.forename: M L
authors.initials: ML
authors.lastname: Godley
authors.forename: R A
authors.initials: RA
authors.lastname: Risdon
authors.forename: P G
authors.initials: PG
authors.lastname: Ransley
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000000981:diagnostic imaging / Q000254:growth & development / Q000503:physiopathology*; D008297:Male; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D004113:Succimer; D013438:Sulfhydryl Compounds; D013552:Swine; D013556:Swine, Miniature; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014718:Vesico-Ureteral Reflux / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004113:Succimer