title: [Spectrophotometric determination of complex formation constants of naproxen with caffeine, nicotinamide and salicylic acid in aqueous solution].
abstract: The interaction between water insoluble drug naproxen with caffeine, nicotinamide and salicylic acid in aqueous solutions were determined by spectrophotometry. Naproxen was found to form 1:1 molecular complex with these substances. The complex formation constants were determined by spectrophotometry at room temperature. The thermodynamic functions associated with complexation of naproxen-drugs were also evaluated. It may be concluded that the complex formation may be attributed to hydrogen bonding since enthalpy changes were shown to be a few KJ.mol-1.
authors.forename: Q H
authors.initials: QH
authors.lastname: Shi
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: X D
authors.initials: XD
authors.lastname: Liu
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D002110:Caffeine / Q000032:analysis; D008024:Ligands; D009288:Naproxen / Q000032:analysis*; D009536:Niacinamide / Q000032:analysis; D012459:Salicylates / Q000032:analysis; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008024:Ligands; D012459:Salicylates; D012996:Solutions; D009536:Niacinamide; D002110:Caffeine; D009288:Naproxen