title: Differential effects of parenteral nutrition on tumor growth and erythrocyte polyamine levels in the rat.
abstract: The influence of total parenteral nutrition (TPN) on tumor growth and erythrocyte polyamine levels was evaluated in rats with a transplantable fibrosarcoma or a Ward colon tumor. During the experimental periods the fibrosarcoma grows exponentially when rats are fed chow ad libitum while the colon tumor reaches a plateau of its Gompertzian growth curve. A 12-day regimen of TPN resulted in an increased growth of the colon tumor but not the fibrosarcoma. The erythrocyte putrescine levels of fibrosarcoma-bearing rats and the levels of putrescine, spermidine, and spermine of Ward colon-tumor-bearing rats were significantly increased by TPN compared with similarly treated nontumor-bearing (NTB) rats. When the growth of the fibrosarcoma was slowed by feeding a restricted intake (RI) regimen, a subsequent 6-day regimen of TPN resulted in increased tumor growth. Erythrocyte polyamine levels of fibrosarcoma-bearing, RI-rats were elevated by TPN repletion. There was a consistent, significant, interaction between TPN and tumor presence on the erythrocyte putrescine levels in fibrosarcoma-bearing rats and the levels of all polyamines in Ward colon-tumor-bearing rats. The effects of TPN on tumor growth and erythrocyte polyamine levels of tumor-bearing rats may be dependent on the growth characteristics of the tumor. The data demonstrate that TPN consistently enhanced the tumor contribution to the erythrocyte putrescine pool.
authors.affiliation: Department of General Surgery, University of Texas M. D. Anderson Cancer Center, Texas 77030.
authors.forename: V B
authors.initials: VB
authors.lastname: Grossie
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: T H
authors.initials: TH
authors.lastname: Chang
authors.forename: D
authors.initials: D
authors.lastname: Patenia
authors.forename: M M
authors.initials: MM
authors.lastname: Benitez
authors.forename: J A
authors.initials: JA
authors.lastname: Ajani
authors.forename: D M
authors.initials: DM
authors.lastname: Ota
mesh_terms: D000818:Animals; D015415:Biomarkers; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*; D004912:Erythrocytes / Q000378:metabolism*; D005354:Fibrosarcoma / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D010289:Parenteral Nutrition, Total; D011073:Polyamines / Q000097:blood*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D015415:Biomarkers; D011073:Polyamines