title: Correlation between arterial blood pressure and oxygenation in tetralogy of Fallot.
abstract: To examine the relationship between arterial blood pressure and oxygenation in patients undergoing complete surgical correction of tetralogy of Fallot, a retrospective study of 16 patients was first performed, looking at the correlation between mean arterial blood pressure (MAP) and arterial oxygen tension (PaO2). The correlation between phenylephrine-induced changes in MAP (delta MAP) and those in PaO2 (delta PaO2) was investigated prospectively in seven patients. In the retrospective study, there was a significant correlation between MAP and PaO2 (n = 66; r = 0.55; P less than 0.01), and most data points with a PaO2 less than 50 mm Hg were associated with a MAP less than 60 mm Hg. In the seven patients who received phenylephrine, 10 micrograms/kg, a significant correlation was found between delta MAP and delta PaO2 (n = 10; r = 0.95; P less than 0.01). These results suggest that in tetralogy of Fallot arterial blood pressure is a determinant of arterial oxygenation, and that the risk of serious hypoxia is significant when MAP is less than 60 mm Hg.
authors.affiliation: Department of Anesthesiology, Yamaguchi University Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oshita
authors.forename: R
authors.initials: R
authors.lastname: Uchimoto
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Saka
authors.forename: H
authors.initials: H
authors.lastname: Takeshita
authors.forename: N
authors.initials: N
authors.lastname: Funatsu
mesh_terms: D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D006221:Halothane; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007223:Infant; D010100:Oxygen / Q000097:blood*; D010656:Phenylephrine / Q000494:pharmacology; D011446:Prospective Studies; D012189:Retrospective Studies; D013771:Tetralogy of Fallot / Q000097:blood / Q000503:physiopathology / Q000601:surgery*
chemical_list: D010656:Phenylephrine; D010100:Oxygen; D006221:Halothane