[Uptake of osteotropic agents in the spine in laboratory rats after the administration of biphenyl derivatives].
The effect of the derivative trichlorobiphenyl and of ergocalciferol on calcium uptake into the spinal column was studied in young laboratory rats. The substances were administered in the period of suckling. Before sacrificing the animals the bone seeker 85 Sr was administered. The uptake of the seeker decrease after administration of the derivative trichlorobifenyl. Ingestion of the biphenyl derivative and of ergocalciferol resulted in a mild increase in bone seeker uptake. The increase was comparable to the uptake level in control animals. The effect of the derivative trichlorobiphenyl is accounted for by blockade of cytoplasmic receptors of chondrocytes.
Krcek
L
L
Novák
M
M
Vávrová
M
M
Hovorková
A
A
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004872:Ergocalciferols / Q000494:pharmacology; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D011877:Radionuclide Imaging; D051381:Rats; D013131:Spine / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D013326:Strontium Radioisotopes / Q000378:metabolism
D004872:Ergocalciferols; D013326:Strontium Radioisotopes; C015550:2,4',5-trichlorobiphenyl; D011078:Polychlorinated Biphenyls; D002118:Calcium
Príjem osteotropného prvku v chrbtici laboratórneho potkana po aplikácii derivátu bifenylu.