The beneficial effects of ibuprofen on a lethal live E. coli septic shock model and the relationship of these effects to superoxide radical production.
Schmeling
D J
DJ
Department of Surgery, Mott Children's Hospital, University of Michigan, Ann Arbor 48109-0245.
Drongowski
R A
RA
Coran
A G
AG
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000150:complications; D005440:Fluid Therapy; D005609:Free Radicals; D006439:Hemodynamics / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D009570:Nitriles; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D018805:Sepsis / Q000150:complications; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013481:Superoxides / Q000096:biosynthesis*; D014325:Tromethamine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D005609:Free Radicals; D009570:Nitriles; D014325:Tromethamine; D013481:Superoxides; C022028:lodoxamide tromethamine; D014969:Xanthine Oxidase; D010072:Oxamic Acid; D004298:Dopamine; D007052:Ibuprofen