Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci.
The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait.
Klinken
S P
SP
Laboratory of Immunopathology, National Institutes of Health, Bethesda, Maryland 20892.
Hartley
J W
JW
Fredrickson
T N
TN
Rapp
U R
UR
Morse
H C
HC
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology; D004198:Disease Susceptibility; D007942:Leukemia, Experimental / Q000235:genetics* / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D009053:Sarcoma Viruses, Murine / Q000472:pathogenicity*
D009856:Oncogene Proteins, Viral