[Influence of a rachitogenic regime on hepatic metabolism in the rat].
We have previously reported that rats fed on the Steenbock and Black's rickets-inducing diet (deficient in vitamin D and with an altered Ca/P ratio) show metabolic modifications in kidney and intestinal mucosa. We have therefore decided to investigate if also in liver, seat of vitamin D hydroxylation, changes in the metabolic pattern occur. An increase of mitochondrial NAD+-dependent isocitrate dehydrogenase and a decrease of citrate and ATP content was demonstrated in liver of rachitic rats, together with changes in ATP-citrate lyase and glucose-6-phosphate dehydrogenase activity. The inhibitory effect of ATP on liver mitochondria NAD+-dependent isocitrate dehydrogenase was also studied.
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Dipartimento di Scienze Biochimiche Università di Firenze, Italie.
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Vincenzini
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D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012279:Rickets / Q000378:metabolism*
D002951:Citrates; D009243:NAD; D019343:Citric Acid; D009249:NADP; D000255:Adenosine Triphosphate; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase
Influence d'un régime rachitigène sur le métabolisme hépatique du rat.