[Aztreonam and oxacillin in the treatment of febrile neutropenic patients with solid tumors].
22 consecutive febrile episodes in 21 neutropenic (PMN less than 1000/mmc) cancer patients, were treated with aztreonam and oxacillin. Nineteen patients were severely neutropenic (PMN less than 500/mmc). Cure was obtained in 86% of the febrile episodes, including 6/7 bacteriologically documented gram negative infections. No major side effects were observed. These results seem to indicate that aztreonam is effective as empiric treatment of gram negative infections in neutropenic patients. However, it must be used in combination with another antibiotic to ensure gram positive coverage.
Natali
M
M
Tonini
G
G
Tufo
E
E
Leggio
M
M
Carassai
A
A
Lopez
M
M
D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000209:etiology*; D001398:Aztreonam / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D009503:Neutropenia / Q000209:etiology*; D010068:Oxacillin / Q000627:therapeutic use*
D001398:Aztreonam; D010068:Oxacillin
Aztreonam ed oxacillina nel trattamento dei pazienti febbrili neutropenici con tumori solidi.