[Activity of adenosine metabolism enzymes and spontaneous chemiluminescence in macrophages in the tumor growth process].
Adenosine deaminase and 5'-nucleotidase activities as well as chemiluminescence emission were measured in peritoneal macrophages of Syrian hamsters in the growth process of tumours with different grade of malignancy. The adenosine deaminase activity was established to decrease, while the 5'nucleotidase activity--to increase in macrophages after the subcutaneous injection of tumour cells with high level of malignancy as compared with these values in normal cells. This is accompanied by a decrease of the macrophage chemiluminescence during the whole experimental period. At the same time adenosine deaminase and 5'-nucleotidase activities as well as chemiluminescence emission in peritoneal macrophages of hamsters treated with low-malignancy cells do not differ from these values in the control group.
Umanskiĭ
V Iu
VIu
Kashkina
L M
LM
Prilutskaia
M O
MO
D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D006224:Cricetinae; D049449:Luminescence; D008264:Macrophages / Q000201:enzymology*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D009700:Nucleoside Deaminases / Q000378:metabolism*; D009708:Nucleotidases / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000201:enzymology / Q000473:pathology
D009708:Nucleotidases; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine
Aktivnost' fermentov obmena adenozina i spontannaia khemiliuminestsentsiia v makrofagakh v protsesse rosta opukholeĭ.