title: The Fc epsilon R2/CD23 antigen: a hallmark of chronic lymphocytic leukemia B cells.
abstract: The effect of different stimuli on the expression of the low-affinity receptor for the Fc fragment of IgE (Fc epsilon R2/CD23) on peripheral blood B cells from patients with chronic lymphocytic leukemia (CLL) was investigated. CLL B cells cultured for 3 days in medium alone showed a progressive decrease of the Fc epsilon R2/CD23 expression, while the addition to the cell cultures of IgE or interleukin-4 had a slackening effect on the decrease of the Fc epsilon R2/CD23. In contrast, in the presence of interferon-gamma the proportion of Fc epsilon R2/CD23+ cells was more rapidly reduced compared to CLL B cells cultured in medium alone. Stimulation of CLL B cells with Staphylococcus aureus Cowan I (SAC) bacteria, which are able to enhance the expression of Fc epsilon R2/CD23 on normal B cells, induced a rapid loss of the Fc epsilon R2/CD23 from CLL B cells.
authors.affiliation: Cattedra di Allergologia e Immunologia Clinica, Università degli Studi di Firenze.
authors.forename: F
authors.initials: F
authors.lastname: Almerigogna
authors.forename: R
authors.initials: R
authors.lastname: Biagiotti
authors.forename: M G
authors.initials: MG
authors.lastname: Giudizi
authors.forename: A
authors.initials: A
authors.lastname: Alessi
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: A
authors.initials: A
authors.lastname: Bosi
authors.forename: S
authors.initials: S
authors.lastname: Romagnani
mesh_terms: D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D007700:Kinetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D011994:Recombinant Proteins / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D007378:Interleukins; D011961:Receptors, Fc; D017455:Receptors, IgE; D011994:Recombinant Proteins; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma