Levels of protein S during the normal menstrual cycle and in women on oral contraceptives low in estrogen.
Total protein S, a coagulation regulating protein, was determined by an electroimmunoassay in samples of plasma collected during one menstrual or hormone-induced cycle in 15 young women and 11 women using oral contraceptives with 30 micrograms ethinyl estradiol and 150 micrograms levonorgestrel. Distinct individual levels caused the with-in-group variations of plasma total protein S to be larger than the individual variations. There was no statistically significant difference between the groups, but in the hormone group there was a slight but statistically significant decrease during the hormone-induced cycle.
Jespersen
J
J
Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark.
Nielsen
M T
MT
D000328:Adult; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D009644:Norgestrel / Q000494:pharmacology*; D017293:Protein S
D004338:Drug Combinations; D006023:Glycoproteins; D017293:Protein S; D009644:Norgestrel; D004997:Ethinyl Estradiol