Lowering of blood glucose in athymic nude mice and rats, grafted with human lung cancers.
Human tumors were transplanted into athymic nude mice. From blood samples in the final stage of their passages we observed that in some of these lines, human lung cancer lines mostly, blood glucose generally decreased with increasing size of the tumor grafts. This observation was the reason for further investigations. Eight out of 13 human lung cancer lines caused a decrease of blood glucose in grafted mice. The extent of decrease was directly correlated with the proliferation of grafts. The results raise hope that the model of human malignant tumors, xenotransplanted and passaged into athymic nude mice, could be helpful in research on IGF and related substances.
Fortmeyer
H P
HP
TVA des Univ. Klinikum, Frankfurt/Main, F.R.G.
Hick
J
J
Blum
U
U
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D051381:Rats; D011923:Rats, Nude; D014183:Transplantation, Heterologous
D001786:Blood Glucose