title: Plasma concentrations of human atrial natriuretic peptide at vaginal delivery and elective cesarean section.
abstract: The change in plasma concentration of atrial natriuretic peptide (hANP) at delivery was examined by measuring the concentrations of hANP in plasma samples from 21 subjects after 36 weeks of normal pregnancy, 22 subjects after normal spontaneous delivery and 20 subjects after elective cesarean section. The maternal plasma concentration of hANP after normal delivery (38.0 +/- 8.2 fmol/ml, mean +/- S.E.M.) was significantly higher than that after 36 weeks of normal pregnancy (16.8 +/- 2.3 fmol/ml), but its concentration after cesarean section was not different from that after 36 weeks of pregnancy. After normal delivery, the plasma concentration of hANP in the umbilical artery (66.9 +/- 11.8 fmol/ml) was also significantly higher than that in the umbilical vein (35.1 +/- 7.3 fmol/ml). In contrast, after elective cesarean section, the hANP levels in the umbilical artery and vein were not significantly different. These results suggest that hANP secretion into the maternal and fetal circulation may be stimulated by the dynamic movement of the mother in labour and the stress of the fetus at delivery, respectively.
authors.forename: E
authors.initials: E
authors.lastname: Okamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Otsuki
authors.forename: I
authors.initials: I
authors.lastname: Iwata
authors.forename: E
authors.initials: E
authors.lastname: Nishino
authors.forename: N
authors.initials: N
authors.lastname: Mitsuda
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: N
authors.initials: N
authors.lastname: Sugita
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: D009320:Atrial Natriuretic Factor