Respiratory effects of epidural morphine and sufentanil in the absence and presence of chlordiazepoxide.
The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed when rats had been pretreated with chlordiazepoxide. With chlordiazepoxide, respiratory depression after epidural injection of the longer acting and poorly lipid-soluble morphine could still be observed when analgesic activity had disappeared. The data are explained most parsimoniously by assuming that stress counteracts the respiratory effects of epidural opiates, and that late respiratory depression can occur in as much as the opiate continues to act at points of time when the effects of stress have disappeared.
Van den Hoogen
Rob H W M
RHWM
Diaconessenhuis, Houtlaan 55, 2300 RD LeidenThe Netherlands Department of Psychopharmacology, Janssen Pharmaceutica, 2340 BeerseBelgium.
Bervoets
Karin J W
KJW
Colpaert
Francis C
FC
D015360:Analgesia, Epidural; D000818:Animals; D002707:Chlordiazepoxide / Q000008:administration & dosage* / Q000627:therapeutic use; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013312:Stress, Physiological / Q000188:drug therapy*; D017409:Sufentanil
D002707:Chlordiazepoxide; D009020:Morphine; D017409:Sufentanil; D005283:Fentanyl