Does HIV cause salivary gland disease?
HIV-associated salivary gland disease (HIV-SGD) is characterized by enlargement of the major salivary glands and/or xerostomia. HIV does not appear to play a direct role in this disease since it was detected by immunohistochemistry in only occasional lymphocytes in labial salivary glands in two out of six patients; it was not found in the salivary gland epithelial cells. Moreover, HIV was not found in any of 21 saliva samples from seven patients. We conclude that HIV-SGD is not caused by direct infection of the salivary glands with HIV.
Schiødt
M
M
Oral AIDS Center, University of California, San Francisco.
Greenspan
D
D
Levy
J A
JA
Nelson
J A
JA
Chernoff
D
D
Hollander
H
H
Greenspan
J S
JS
D000328:Adult; D002648:Child; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000382:microbiology*; D012466:Salivary Gland Diseases / Q000150:complications*; D012469:Salivary Glands / Q000382:microbiology*
D015483:HIV Antibodies; D015488:HIV Antigens