Cytogenetic findings in two synovial sarcomas.
Cytogenetic analysis was performed after short-term tissue culture of two recurrent synovial sarcomas. The tumors were classified on the basis of morphology, location, and immunohistochemistry. In a poorly differentiated tumor, the karyotype 49,XY, +7, +8, +19,t(5:18) (q11.2;q11.2), and in a biphasic tumor two clonal cell lines with common translocations t(X;18)(p11.2;q11.2) and t(12;17)(p11.2;q11.2) were present. In the predominant cell line several other structural aberrations including t(1;12)(q21;q24.3), t(3;18)(p23;q21), and 17p+ were found. A comparison of our results with previously published studies suggests that in addition to t(X;18), translocations of chromosome 18 with other chromosomes may represent a consistent feature of chromosomal changes in synovial sarcoma.
Limon
J
J
Department of Biology and Genetics, Medical Academy, Gdańsk, Poland.
Mrózek
K
K
Nedoszytko
B
B
Babińska
M
M
Jaśkiewicz
J
J
Kopacz
A
A
Zółtowska
A
A
Borowska-Lehman
J
J
D000328:Adult; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D006801:Humans; D007621:Karyotyping; D008297:Male; D009364:Neoplasm Recurrence, Local; D013584:Sarcoma, Synovial / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured; D014960:X Chromosome