[Cationic proteins from neutrophils as inhibitors of nonenzymatic fibrinolytic and anticoagulant activity of blood plasma].
Two cation proteins free of enzymatic activity, containing one and four peptides (CP-1 and CP-4, respectively), were studied. The cation protein consisting of four peptides proved to be the most effective inhibitor of the nonenzymatic fibrinolytic activity of heparin-containing complexes. Both these cation proteins inhibited similarly the anticoagulation activity of blood plasma. The drugs, like cation proteins, appear to be potentially important for clinical practice under conditions of excessive hemorrhage caused by elevated level in circulation of complexes containing heparin and proteins.
Kudriashov
B A
BA
Liapina
L A
LA
Kokriakov
V N
VN
Azieva
L D
LD
Pigarevskiĭ
V E
VE
D000818:Animals; D000925:Anticoagulants / Q000037:antagonists & inhibitors*; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D051381:Rats
D000925:Anticoagulants; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; C030509:neutrophil basic proteins; D005341:Fibrinolysin
Kationnye belki iz neĭtrofilov kak ingibitory nefermentativnoĭ fibrinoliticheskoĭ i antikoaguliantnoĭ aktivnosti plazmy krovi.