title: Pathways and control of adenine nucleotide catabolism in anoxic rat hepatocytes.
abstract: Studies are reviewed that show that in isolated rat hepatocytes subjected to anoxia, the catabolism of AMP, leading to uric acid instead of to allantoin in normoxia, proceeds almost exclusively by deamination of AMP followed by dephosphorylation of IMP. Adenosine, which is nearly undetectable in normoxic cell suspensions, accumulates to a slight extent in anoxia. The regulatory properties of liver AMP deaminase and cytosolic IMP-GMP 5'-nucleotidase were found to provide protective mechanisms for the hepatic adenine nucleotide pool in hypoxia.
authors.affiliation: Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Van Den Berghe
authors.forename: M F
authors.initials: MF
authors.lastname: Vincent
authors.forename: F
authors.initials: F
authors.lastname: Bontemps
mesh_terms: D015720:5'-Nucleotidase; D000659:AMP Deaminase / Q000378:metabolism; D000227:Adenine Nucleotides / Q000378:metabolism*; D000241:Adenosine / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000693:Anaerobiosis; D000818:Animals; D002478:Cells, Cultured; D000860:Hypoxia / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009708:Nucleotidases / Q000378:metabolism; D051381:Rats
chemical_list: D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000659:AMP Deaminase; D000241:Adenosine