[The effectiveness of 2 systems of chemoradiation treatment in inoperable small-cell lung cancer].
A comparative evaluation of treatment results was carried out in two groups of patients with small-cell lung cancer; in group 1, patients received radiation and chemotherapy simultaneously (68 cases) while in group 2 chemotherapy was followed by radiation (67 cases). Complete remission was observed in 62% in group 1. In group 2, it was 7% immediately after chemotherapy to soar up to 46% following radiation treatment. Radiation-induced pneumosclerosis was roentgenologically detected in all those followed up and presented with symptoms in 12.5% and 27.6% in groups 1 and 2, respectively. The frequency of distant metastasis in patients with complete and partial remission was identical in both groups. Metastasis-free period was significantly longer in complete remission patients as compared to those with partial remission; it was still longer in chemotherapy responders in group 2. The procedure involving sequential chemo- and radiation treatment should be preferred.
Mikhina
Z P
ZP
Bychkov
M B
MB
Motorina
L I
LI
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D008168:Lung / Q000473:pathology / Q000528:radiation effects; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology; D011897:Random Allocation; D012074:Remission Induction; D012598:Sclerosis; D013997:Time Factors
Effektivnost' dvukh sistem khimioluchevogo lecheniia pri neoperabel'nom melkokletochnom rake legkogo.