Effect of prostaglandin E2 on pokeweed mitogen-activated human lymphocyte cultures.
It is shown that a short incubation of peripheral human lymphocytes with PGE2 is able to reduce the B cell differentiation induced by PWM. The target of PGE2 action appears to belong to T lymphocytes, since the treatment of non-T cells is uneffective in reducing the immune response. Both OKT4+ and OKT8+ subsets are sensitive to PGE2. Data concerning the role of endogenous as well as exogenous PGE2 either on unfractionated or fractionated OKT4+, OKT8+ and non-T lymphocytes are also discussed. The PGE2 inhibition on immunoglobulin synthesis in PWM-stimulated cultures seems to be mediated by a complex effect on both the T cell subsets.
Teti
D V
DV
Institute of General Pathology, University of Messina, Medical School, Italy.
Cavallaro
A
A
Valenti
A
A
Santarpia
G
G
Sofo
V
V
Misefari
A
A
D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D015704:CD4 Antigens; D016827:CD8 Antigens; D002454:Cell Differentiation / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D011043:Pokeweed Mitogens; D015232:Dinoprostone