title: Exercise capacity after single and twice-daily doses of nicorandil in chronic stable angina pectoris.
abstract: In a double-blind parallel group study, 46 patients with chronic stable angina were randomized, after a 2-week placebo washout period, to 1 of 3 treatment groups for an additional 2 weeks. Groups 1 and 2 received nicorandil (5 mg, n = 5; 10 mg, n = 10) twice daily, respectively, increasing to 10 and 20 mg (n = 20) twice daily after 1 week of treatment; group 3 continued to receive placebo. A symptom-limited Bruce protocol exercise test was performed before and 2 hours after the initial dose and, after 2 weeks of treatment, 2 and 12 hours after administration. The following parameters were measured: resting, peak exercise and recovery blood pressure and heart rate, exercise duration, time to onset of angina and time to 1 mm of ST-segment depression. After initial dosing, there were significant increases in exercise duration (16%--n = 5, n = 10 vs -2% [placebo]) and time to onset of angina (20%, n = 5; 26%, n = 10 vs 5% [placebo]) (p less than 0.05). Time to onset of 1 mm of ST-segment depression increased in the nicorandil-treated groups compared with that in the placebo group (27%, n = 5; 25%, n = 10 vs 8% [placebo]). Calculated total exercise work increased in both nicorandil groups compared with exercise work in the placebo group (30%, n = 5; 19%, n = 10 vs 3% [placebo]). A decrease in resting systolic blood pressure (12%) in the 10-mg group was the only significant alteration in the hemodynamic parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, Kings College Hospital, United Kingdom.
authors.forename: T B
authors.initials: TB
authors.lastname: Meany
authors.forename: P
authors.initials: P
authors.lastname: Richardson
authors.forename: A J
authors.initials: AJ
authors.lastname: Camm
authors.forename: J
authors.initials: J
authors.lastname: Coltart
authors.forename: M
authors.initials: M
authors.lastname: Griffith
authors.forename: M B
authors.initials: MB
authors.lastname: Maltz
authors.forename: M
authors.initials: M
authors.lastname: Signy
mesh_terms: D000284:Administration, Oral; D000787:Angina Pectoris / Q000188:drug therapy*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020108:Nicorandil; D005082:Physical Exertion; D010919:Placebos; D011897:Random Allocation; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D010919:Placebos; D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil