[Detection of immune complexes in the sera and around the muscle fibers in a case of myasthenia gravis and polymyositis].
A case of myasthenia gravis accompanied with polymyositis and malignant thymoma, detected immune complexes in the sera and around the muscle fibers, was described. A 37-year-old woman was admitted to Shinshu University Hospital in September, 1987 because of dyspnea, dysphagia and muscle weakness. She first noticed her right blepharoptosis 3 weeks before admission. Weakness of all four limbs and myalgia of lower extremities were noticed one week later. These symptoms got worse and nocturnal dyspnea, dysphagia and easy fatigability at mastication appeared. On admission, she looked ill and neurological examination revealed left blepharoptosis, bilateral facial weakness, weakness of all four limbs, more prominent in proximal muscles and tenderness of lower extremities. Edrophonium test was positive, improving her muscle weakness. Laboratory examination revealed the elevated serum levels of CK, the increased titre of circulating immune complexes and high titres of acetylcholine receptor antibodies and anti-skeletal muscle antibodies. Electromyographic study showed myogenic pattern and Harvey-Masland test revealed waning at low frequency stimulation. Muscle biopsy showed marked perivascular infiltration of lymphocytes, accompanied by phagocytosis and interstitial fibrosis. IgG deposits were shown around the muscle fibers exclusively around the infiltrates of mononuclear cells. Granular deposits of C3 were also shown specifically around the muscle fibers exclusively around the infiltrates of mononuclear cells. Thymectomy was performed on September 21, 1987. Invasion of thymoma, predominantly lymphocytic type, to right lung and pericardium was observed histologically. After thymectomy, she got better. Immunological data and immunohistochemical examination of the present case suggest that in the case of myasthenia gravis accompanied with polymyositis and malignant thymoma, immune complexes may play a primary role on the pathogenesis of myositis.
Shimada
K
K
Koh
C S
CS
Tsukada
N
N
Shoji
S
S
Yanagisawa
N
N
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology / Q000276:immunology; D009132:Muscles / Q000276:immunology*; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology*; D009220:Myositis / Q000209:etiology / Q000276:immunology*; D013945:Thymoma / Q000150:complications / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology
D000936:Antigen-Antibody Complex