title: [Retinoids: the new status. Maintenance therapy, disorders of resorption in "non-responders", interactions and interferences with drugs, treatment of children and bone toxicity, acitetin and 13-cis-acitretin].
abstract: Oral retinoids are now well-established drugs for the systemic treatment of skin diseases. For etretinate to be effective on a long-term basis it is recommended that maintenance therapy should be continued for 3-6 months after clinical signs of the disease have disappeared. In "non-responders" with psoriasis the blood levels of etretinate may be low and increasing the dose to 1.5 mg/kg body weight per day will be necessary and helpful in some cases. The interaction of drugs should also be considered carefully in non-responding individuals. Children usually respond well to treatment, but they also often require higher dose levels. Bone toxicity with premature epiphyseal closure and hyperostoses may be seen during isotretinoin administration and, more rarely, in patients receiving etretinate, but the risk is relatively low. Teratogenicity is a major concern in young females being treated for acne with isotretinoin, since 70 embryopathies have been recorded worldwide.
authors.affiliation: Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz der Freien Universität Berlin.
authors.forename: C E
authors.initials: CE
authors.lastname: Orfanos
mesh_terms: D017255:Acitretin; D000328:Adult; D001842:Bone and Bones / Q000187:drug effects; D002648:Child; D006801:Humans; D007408:Intestinal Absorption; D008134:Long-Term Care; D012176:Retinoids / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D014212:Tretinoin / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D012176:Retinoids; D014212:Tretinoin; D017255:Acitretin
vernacular_title: Retinoide: der neue Stand. Erhaltungstherapie, Resorptionsstörungen bei "non-responders", Interaktionen und Interferenzen mit Medikamenten, Behandlung von Kindern und Kochentxizität, Acitretin und 13-cis-Acitretin.