[Effect of the thromboxane synthetase inhibitor dazmegrel (UK 38,485) on skin blood flow in deep partial thickness burns].
We have previously demonstrated more rapid wound healing in deep partial thickness burn guinea-pigs treated with intramuscular injection of the lower dosage of the thromboxane synthetase inhibitor Dazmegrel. In striking contrast, systemic and topical application of larger dosage of Dazmegrel inhibited or did not improve wound healing in this study, a deep partial thickness burn model of guinea-pig was used to evaluate the effect of Dazmegrel given systemically using dosage of 3.4 mg, 10 mg and 30 mg/kg/day on dermal perfusion measured by India ink injection or by Xe-133 clearance. There was no improvement of dermal perfusion in any of the groups receiving Dazmegrel. The beneficial effect of Dazmegrel on wound healing at a dosage of 3.4 mg/kg/day was not due to improved local dermal perfusion but, rather, resulted from a systemic immune effect on the animal. The Xe-133-determined blood perfusion showed a significantly diminished blood perfusion in the burn wound at 7h post-burn, and a higher burn skin blood flow at 24h post-burn. Their finding is consistent with the report from other laboratory that microvascular perfusion in zone-of-stasis burns, immediately post-burn, gradually diminishes to nil over the next 16 hours, to be followed by reperfusion between 16 and 96 hours postburn.
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D000818:Animals; D002056:Burns / Q000188:drug therapy*; D006224:Cricetinae; D005260:Female; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014945:Wound Healing / Q000187:drug effects
D007093:Imidazoles; C039242:dazmegrel; D013930:Thromboxane-A Synthase