[The effect of hypothermia on the Ca2+-pump in sarcoplasmatic reticulum during autolysis of the myocardium].
Certain hypothermia action mechanisms on Ca2(+)-pump of the sarcoplasmic reticulum in rat myocardium autolysis are investigated. The complex dependence of Ca2(+)-transporting system preservation in autolysis on the depth of hypothermia is shown. The role of lipid peroxidation and endoproteolysis in a decrease of the autolysing myocardium Ca2(+)-pump activity is considered. A conclusion is drawn that hypothermia does not affect the accumulation of peroxidation products in sarcoplasmic reticulum membranes during myocardium autolysis. The protective action of deep hypothermia on the autolysing myocardium Ca2(+)-pump is realized, at least partially, due to an increase in the Ca2(+)-ATPase active molecules number.
Brovkovich
V M
VM
Iarmysh
N V
NV
D000818:Animals; D001329:Autolysis; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D007036:Hypothermia, Induced; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*
D000252:Calcium-Transporting ATPases; D002118:Calcium
Deĭstvie gipotermii na Ca2+-nasos sarkoplazmaticheskogo retikuluma pri avtolize miokarda.