title: Spontaneous rupture of adult Wilms' tumor.
abstract: Wilms' tumor is uncommon in adults, and spontaneous retroperitoneal hemorrhage as the presenting sign of renal malignancy also is rare. A 22-year-old man with spontaneous rupture of a Wilms' tumor, who died within 5 months, is described. The factors that probably contributed to his rapid demise included preoperative tumor spilling, unfavorable histology, and the omission of radiotherapy owing to poor patient compliance. Although Wilms' tumor is known to have a poorer prognosis in adults than in children, the reason for this is not known. Due to the limited number of cases reported, the optimal treatment for adult Wilms' tumor remains to be defined. However, the recent literature indicates that radical surgery combined with maximal radiotherapy dosage and modification of the chemotherapy schedules used in children may be required to improve the prognosis for adults with Wilms' tumor.
authors.affiliation: Department of Urology, Tygerberg Hospital, South Africa.
authors.forename: C F
authors.initials: CF
authors.lastname: Heyns
authors.forename: D J
authors.initials: DJ
authors.lastname: Rossouw
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D010349:Patient Compliance; D012422:Rupture, Spontaneous; D009396:Wilms Tumor / Q000150:complications* / Q000473:pathology / Q000628:therapy