Nucleotide sequence and structural organization of the human FMS proto-oncogene.
The human proto-oncogene c-fms [FMS] on chromosome 5q33.3 encodes a transmembrane glycoprotein with tyrosine kinase activity that functions as the cell surface receptor for the macrophage colony stimulating factor (CSF-1 or M-CSF). Overlapping bacteriophage clones that included 35 kb of the FMS locus and contained the complete coding sequence of the CSF-1 receptor were subjected to nucleotide sequencing analysis. Comparison with the cDNA sequence of the human c-fms gene indicated that at least one 5' noncoding exon is located far upstream (ca. 26 kb) from sequences encoding the CSF-1 receptor. The FMS coding sequence consists of 21 small exons and heterogeneously sized introns, ranging from 6.3 kb to less than 0.1 kb in complexity.
Hampe
A
A
Laboratoire d'Hematologie Experimentale, Centre Hayem, Hospital Saint Louis, Paris, France.
Shamoon
B M
BM
Gobet
M
M
Sherr
C J
CJ
Galibert
F
F
D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D016186:Receptor, Macrophage Colony-Stimulating Factor; D012091:Repetitive Sequences, Nucleic Acid
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D004247:DNA; D016186:Receptor, Macrophage Colony-Stimulating Factor