Treatment of adolescents with major depression: implications of the DST and the melancholic clinical subtype.
Of 38 adolescents hospitalized with major depression, 47% of those receiving psychosocial treatment alone responded. Of the non-responders then treated with combined tricyclic antidepressants and psychosocial treatment, 92% responded. The melancholic subtype and dexamethasone suppression test non-suppression were associated with failure to respond to psychosocial treatment alone. Implications for controlled studies are discussed.
Robbins
D R
DR
Brown University Program in Medicine, Providence, RI.
Alessi
N E
NE
Colfer
M V
MV
D000293:Adolescent; D000639:Amitriptyline / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D003891:Desipramine / Q000627:therapeutic use; D003907:Dexamethasone; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007099:Imipramine / Q000627:therapeutic use; D008094:Lithium / Q000627:therapeutic use; D009661:Nortriptyline / Q000627:therapeutic use; D011379:Prognosis; D011567:Psychiatric Department, Hospital; D011613:Psychotherapy / Q000379:methods
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D003907:Dexamethasone; D008094:Lithium; D009661:Nortriptyline; D007099:Imipramine; D003891:Desipramine; D006854:Hydrocortisone