Clinical significance of serum guanase activity in various liver diseases.
Serum guanase activity was measured using a sensitive colorimetric method in patients with liver diseases. Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases. In addition, the GPT-to-guanase ratio differed chronic hepatitis from liver cirrhosis. These findings suggest that determination of guanase and aminotransferases in useful in differentiation of liver diseases as well as assessing liver damage.
Shiota
G
G
Department of Internal Medicine, Matsue Municipal Hospital, Japan.
Fukada
J
J
Ito
T
T
Tsukizawa
M
M
Yamada
M
M
Sato
M
M
D000410:Alanine Transaminase / Q000097:blood; D000619:Aminohydrolases / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D005260:Female; D006148:Guanine Deaminase / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000201:enzymology; D006801:Humans; D008103:Liver Cirrhosis / Q000201:enzymology; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology; D008297:Male
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000619:Aminohydrolases; D006148:Guanine Deaminase