Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine.
Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight (Mr) 20,000-100,000 and up to 0.08% (w/v) admixture of lipopolysaccharide was obtained by water-salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimulates production of specific protective antibodies in rabbit and does not provoke obvious toxicity in laboratory animals.
Stanislavsky
E S
ES
I.I. Mechnikov Central Research Institute of Vaccines and Sera, Moscow,USSR.
Edvabnaya
L S
LS
Bandman
O A
OA
Boolk
V F
VF
Zhvanetskaya
M I
MI
Vargina
A K
AK
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000633:toxicity; D006168:Guinea Pigs; D007106:Immune Sera / Q000276:immunology; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D051381:Rats
D001428:Bacterial Vaccines; D007106:Immune Sera