[Effectiveness of cicletanine on lesions in spontaneously hypertensive rats. Curative study--dose-effect relationship].
Genetically hypertensive rats receiving a high sodium content diet develop, within weeks of their birth, major alterations of tissues and blood vessels. The purpose of this study was to evaluate the effects of cicletanine, a synthetic antihypertensive drug, on the progress of genetic hypertension. Iffa Credo SHR-SP male rats aged 11 weeks were divided into 4 groups. One group was used as control and 3 groups were treated with oral cicletanine in doses of 10, 30 and 90 mg/kg/day respectively. The control group showed a high mortality rate due to a significant decrease of weight gain and a highly significant increase of blood pressure, these changes being associated with lesions of tissues and vessels in the brain, heart and kidneys. A curative treatment with cicletanine improved these parameters and was accompanied by good tissue preservation. The curative effect of cicletanine seems to be due to an increase in endogenous prostaglandin synthesis.
Droy-Lefaix
M T
MT
IHB/IPSEN, recherche et développement, Le Plessis-Robinson, France.
Ruchoux
M M
MM
Berthet
P
P
Bakri
F
F
Bosquet
D
D
Narcisse
G
G
Guillemain
G
G
D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology; D004232:Diuretics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011725:Pyridines; D051381:Rats; D011918:Rats, Inbred SHR
D004232:Diuretics; D011725:Pyridines; C038068:cicletanine
Efficacité du ciclétanine sur les lésions du rat spontanément hypertendu. Etude curative--relation dose-effet.