Increased interleukin-1 beta (IL-1 beta) concentration in gingival tissue from periodontitis patients.
Human gingival tissues from periodontitis patients were found to contain from 126 fg/mg to 2161 fg/mg interleukin-1 beta as determined by a sensitive enzyme linked immunoassay. No IL-1 beta could be found in normal gingival tissue. This finding may have important consequences relevant to connective tissue destruction and episodes of alveolar bone resorption characteristic of chronic periodontitis.
Hönig
J
J
Rordorf-Adam
C
C
Siegmund
C
C
Wiedemann
W
W
Erard
F
F
D000328:Adult; D001862:Bone Resorption / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005881:Gingiva / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010513:Periodontal Ligament / Q000276:immunology; D010518:Periodontitis / Q000276:immunology*
D007375:Interleukin-1