title: Genetic diversity of enterovirus subgroups.
abstract: Enterovirus serotypes were studied using nucleic acid hybridization and nucleotide sequence analysis. A great majority of enteroviruses could be roughly divided into two larger subgroups the first consisting of poliovirus and certain coxsackievirus A serotypes. The second subgroup included coxsackie B viruses, most ECHO viruses, enterovirus 71 and representatives of coxsackie A viruses. Enterovirus 70 showed low homology to the viruses in both groups. Interestingly, ECHO virus 22 failed to react with any of the hybridization probes indicating a relatively distant relationship. The close relationship between coxsackie B and ECHO viruses as well as between polio and certain coxsackie A viruses was also evident when nucleotide sequences of the 3' end noncoding parts were compared.
authors.affiliation: Department of Virology, University of Turku, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Auvinen
authors.forename: G
authors.initials: G
authors.lastname: Stanway
authors.forename: T
authors.initials: T
authors.lastname: Hyypiä
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D004279:DNA, Viral / Q000235:genetics; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D005814:Genes, Viral; D014644:Genetic Variation; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping
chemical_list: D015342:DNA Probes; D004279:DNA, Viral; D012367:RNA, Viral; D004247:DNA