Comparison of isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate stimulation of thyroxine 5'-deiodinase activity in cultured pineal glands from euthyroid and hypothyroid rats.
Thyroxine 5'-deiodinase was increased by isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate in a dose- and time-related manner in cultured rat pineal gland. Basal and stimulated activity was higher in glands from hypothyroid than from euthyroid animals. Our data suggest direct beta-adrenergic stimulation of intracellular cyclic AMP may be involved in the regulation of pineal thyroxine 5'-deiodinase activity.
Murakami
M
M
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Greer
S E
SE
McAdams
S
S
Greer
M A
MA
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007037:Hypothyroidism / Q000201:enzymology*; D007453:Iodide Peroxidase / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D003994:Bucladesine; D007453:Iodide Peroxidase; D007545:Isoproterenol