Pathogenesis of heart failure.
The myocardium consists of three compartments: cardiac muscle cells; a nutritive microcirculation; and an extracellular matrix composed largely of fibrillar collagen. The hypertrophic remodeling of the myocardium, which involves each of these compartments, can be adaptive or pathologic. This article reviews the remodeling process and the current state of our knowledge regarding the pathogenetic features of pathologic hypertrophy with heart failure.
Weber
K T
KT
University of Chicago Pritzker School of Medicine, Chicago, Illinois.
Janicki
J S
JS
D006332:Cardiomegaly / Q000150:complications / Q000473:pathology; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D009206:Myocardium / Q000648:ultrastructure