The insulin secretory granule.
The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle comprised of a many proteins with different catalytic activities and messenger functions. With the advent of tumour models of the B cells and the application of immunological and molecular cloning techniques considerable progress has been made in recent years towards the elucidation of the structure and function of these granule proteins. A number of examples are selected here for review. Particular emphasis given to how the activities of quite different granule proteins are interdependent and how this contributes to the co-ordination and integration of the organelle's biological functions.
Hutton
J C
JC
Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK.
D000595:Amino Acid Sequence; D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D006180:Proton-Translocating ATPases / Q000378:metabolism
D007328:Insulin; D006180:Proton-Translocating ATPases