title: Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions.
abstract: Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.
authors.affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Kloog
authors.forename: I
authors.initials: I
authors.lastname: Ambar
authors.forename: E
authors.initials: E
authors.lastname: Kochva
authors.forename: Z
authors.initials: Z
authors.lastname: Wollberg
authors.forename: A
authors.initials: A
authors.lastname: Bdolah
authors.forename: M
authors.initials: M
authors.lastname: Sokolovsky
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D018000:Receptors, Peptide; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014757:Viper Venoms / Q000494:pharmacology*
chemical_list: D010716:Phosphatidylinositols; D011950:Receptors, Cholinergic; D018000:Receptors, Peptide; D014662:Vasoconstrictor Agents; D014757:Viper Venoms; C058085:sarafotoxin receptor; C057354:sarafotoxins s6; D002118:Calcium