Tryptophan hydroxylase activity in hypothalamus and brainstem of neonatal and adult rats treated with hydrocortisone or parachlorophenylalanine.
The present study has been undertaken to determine whether glucocorticoid, and parachlorophenylalanine (PCPA, a tryptophan hydroxylase inhibitor) affects tryptophan hydroxylase (TPH) levels in brainstem and hypothalamus of neonatal and adult rats. Our results show that: (1) administration of hydrocortisone causes small but significant increases in TPH activity of neonatal brainstem: (2) treatment with PCPA plus glucocorticoid results in a marked decrease of TPH activity in brainstem and hypothalamus of both neonatal and adult rats.
Park
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DH
Laboratory of Molecular Neurobiology, Cornell University Medical College, Burke Rehabilitation Center, White Plains, New York 10605.
Paivarinta
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Joh
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TH
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D004791:Enzyme Inhibitors; C020261:4-chlorophenylalanine methyl ester; D014365:Tryptophan Hydroxylase; D010134:Fenclonine; D006854:Hydrocortisone