title: 3-year study for the prevention of perinatal HBV infection under the standard method of the Ministry of Health and Welfare, Japan.
abstract: We present the first report on a 3-year study for the prevention of HB virus infection under the standard method of the Ministry of Health and Welfare, Japan. We observed 50 children for three years, and obtained the following results: 1) Many children (57%) born to HBeAg-positive mothers maintained HBs-antibody titers higher than 10, expressed by the cut-off index based on the RIA system; 2) No case became an HB virus carrier after one year; 3) Six children born to HBe-antibody positive mothers had HBs-antibody titers below 5. Children born to HBe-antigen positive mothers were mostly affected by the HB virus, so that their HBs-antibody titers were maintained at high levels. In contrast, HBs-antibody titers of children born to HBe-antibody positive mothers decreased, probably because of lack of exposure to the HB virus.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabe
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D017325:Hepatitis B Vaccines; D006801:Humans; D007564:Japan; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D014761:Viral Hepatitis Vaccines
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines