Deficits in beam-walking after neonatal motor cortical lesions are not spared by fetal cortical transplants in rats.
Adult rats that sustained unilateral motor cortical lesions at birth demonstrated deficits in traversing an elevated narrow beam. These deficits, manifested by hindlimb slips off the edge of the beam, were not spared in animals that received fetal cortical transplants into the lesion cavity immediately after lesion placement.
Swenson
R S
RS
Department of Anatomy, Loyola University Stritch School of Medicine, Maywood, IL 60153.
Danielsen
E H
EH
Klausen
B S
BS
Erlich
E
E
Zimmer
J
J
Castro
A J
AJ
D000818:Animals; D000831:Animals, Newborn; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology* / Q000637:transplantation*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D009043:Motor Activity; D051381:Rats; D012016:Reference Values