title: Deterioration in immunologic status of human immunodeficiency virus (HIV)-infected homosexual men with lymphadenopathy: prognostic implications.
abstract: Changes in immunologic parameters were followed in members of a cohort of human immunodeficiency virus (HIV)-positive homosexual or bisexual men with lymphadenopathy and were analyzed for differences between those who have and those who have not progressed to the acquired immunodeficiency syndrome (AIDS) (progressors, nonprogressors). T helpers and the Th/Ts ratio were lower in progressors than in nonprogressors both at entry into the study and at the latest visit. T suppressors were not different in the two groups at entry but were higher in nonprogressors at the latest visit. Evaluation of the patterns of change over time showed that T helpers and Th/Ts ratios tended to decrease over time in both nonprogressors and progressors, while T suppressors increased in nonprogressors and decreased in progressors. Although progressors had a greater deterioration in immunologic parameters over time, nonprogressors also had significant deterioration when compared with controls. Based on the respective percentages of men with abnormal or normal T helpers or Th/Ts ratio at entry who have already progressed to AIDS, we would conservatively estimate, considering their latest T helpers and Th/Ts ratio, that at least an additional 16 (32%) of our nonprogressors will develop AIDS in the next 5 years.
authors.affiliation: Division of Host Factors, Centers for Disease Control, Atlanta, Georgia 30333.
authors.forename: T J
authors.initials: TJ
authors.lastname: Spira
authors.forename: J E
authors.initials: JE
authors.lastname: Kaplan
authors.forename: R C
authors.initials: RC
authors.lastname: Holman
authors.forename: L H
authors.initials: LH
authors.lastname: Bozeman
authors.forename: J K
authors.initials: JK
authors.lastname: Nicholson
authors.forename: D B
authors.initials: DB
authors.lastname: Fishbein
mesh_terms: D000386:AIDS-Related Complex / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000911:Antibodies, Monoclonal; D001727:Bisexuality; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D011379:Prognosis; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal