Platelet 3H-imipramine binding sites in depressed patients and healthy controls: a comparison between morning and afternoon samples.
Platelet 3H-imipramine binding was compared between 19 hospitalized, depressed patients and age-matched controls (n = 11). For each individual person blood samples were withdrawn at 8 a.m. and 3 p.m. on two separate occasions (day 0 and day 28). Mean Bmax and Kd values did not differ between depressed patients and healthy controls at any of the four time-points tested, and no significant differences could be established between the different time-points, though there were irregular intraindividual variations.
Gentsch
C
C
Biochemical Laboratory, Psychiatric University Clinic, Basel, Switzerland.
Lichsteiner
M
M
Gastpar
M
M
Gastpar
G
G
Feer
H
H
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011869:Radioligand Assay; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine