The role of renin-angiotensin system in compound 48/80-induced analgesia in rats.
1. The antinociceptive effect of compound 48/80 was reversed by the pretreatment with an angiotensin-converting enzyme (ACE) inhibitor, Hoe 498, in a dose-dependent manner and with a opiate receptor antagonist, naloxone (5.0 mg/kg, s.c.) in rats. 2. The increase of plasma beta-endorphin-like immunoreactivity produced through s.c. administration of compound 48/80 was attenuated by the pretreatment with Hoe 498 but not with naloxone. 3. The present data suggest the possible involvement of renin-angiotensin system in compound 48/80-induced analgesia in rats.
Izumi
H
H
Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.
Hayashi
S
S
D000700:Analgesics; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology; D006400:Hematocrit; D007279:Injections, Subcutaneous; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D017257:Ramipril; D051381:Rats; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D001615:beta-Endorphin / Q000097:blood; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage / Q000494:pharmacology*
D000700:Analgesics; D000806:Angiotensin-Converting Enzyme Inhibitors; D001643:Bridged Bicyclo Compounds; D009270:Naloxone; D003189:p-Methoxy-N-methylphenethylamine; D001615:beta-Endorphin; D012083:Renin; D017257:Ramipril