Effect of lithium carbonate administration singly or in combination with some psychotropic drugs on the radioiodide uptake by mouse thyroid.
The present study dealt with two objects; the first object was to examine whether or not lithium uptake in thyroid is modified by the thyroid state and how the intrathyroidal Li affects iodide uptake by the thyroid. Male and female mice were given lithium carbonate (Li) with propylthiouracil (PTU) or thyroxine (T4). Li was measured by a flameless atomic absorption spectrometry. The total Li content in thyroid was unaffected with PTU or T4, however, Li concentration per unit mass was reduced by PTU but unaffected by T4. The thyroid: serum ratio (T/S) of 125I resulted that the T/S became higher when Li concentration per unit mass was lower and vice versa, suggesting that Li uptake is controlled by thyroid states and Li in the gland interferes with the iodide uptake. Serum triiodothyronine (T3) and T4 by radioimmunoassay showed that PTU alone and in combination with Li lowered serum T4, while a high level of T4 by its supplement was suppressed by co-administration of Li. T3 level was lowered by Li alone, but not severely affected by other drugs. The results suggest that Li enhances T4 clearance without T4-T3 conversion. The second object was to examine the effect of combined psychotropic drugs on thyroid function. Carbamazepine (CBZ), haloperidol (HLP) and imipramine (IPA) were given singly or in combination with Li to examine their effects on the T/S of 125I. Only CBZ reduced the T/S but CBZ plus Li had no summative effect. Neither HLP nor IPA affected the T/S, singly or in combination with Li, suggesting that HLP or IPA does not interfere with an iodide pumping machinery. No distinct sex difference was observed in drug effects.
Takasugi
M
M
Department of Pharmacy, University Hospital, School of Medicine, Tokushima City, Japan.
Teraoka
K
K
Minakuchi
K
K
Akamatsu
S
S
Nishida
M
M
Kamata
N
N
Kuwae
T
T
Kurata
M
M
Kawada
J
J
D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007454:Iodides / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008094:Lithium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D016651:Lithium Carbonate; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D012737:Sex Factors; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D007454:Iodides; D007457:Iodine Radioisotopes; D011619:Psychotropic Drugs; D014284:Triiodothyronine; D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium; D006220:Haloperidol; D007099:Imipramine; D013974:Thyroxine