Brain leukotriene C4 binding sites are S-alkylglutathione binding sites.
Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-alkylglutathione binding sites, possibly microsomal glutathione transferase.
Goffinet
A M
AM
Positron Tomography Laboratory, University of Louvain, Louvain-la-Neuve, Belgium.
Nguyen
A
A
D000478:Alkylation; D000818:Animals; D001923:Brain Chemistry; D005978:Glutathione / Q000378:metabolism*; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018000:Receptors, Peptide; D013189:SRS-A / Q000378:metabolism*
D011956:Receptors, Cell Surface; D018000:Receptors, Peptide; D013189:SRS-A; C035560:glutathione receptor; D005978:Glutathione