[Structure-activity relation for rhodomycin-type antibiotics and the inhibition kinetics of single-stranded and double-stranded DNA- and RNA-viruses].
The antiviral activity of anthracycline antibiotics of rhodomycin group was investigated by two independent methods which determined the infectious units or antigenicity of the viruses. The action of rhodomycin depended on the structure, number, and position of amino sugar in aglycon. The antiviral activity was found to increase in serial order: iremycin--adriamycin--daunomycin--alpha-rubicin--beta-rhodom ycin-- violamycin B I complex by inhibition kinetics determined with adenovirus.
Körting
H J
HJ
Fleck
W
W
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology* / Q000633:toxicity; D000998:Antiviral Agents; D002460:Cell Line; D004267:DNA Viruses / Q000187:drug effects*; D004277:DNA, Single-Stranded / Q000187:drug effects; D004279:DNA, Viral / Q000187:drug effects; D000882:Haplorhini; D015394:Molecular Structure; D012328:RNA Viruses / Q000187:drug effects*; D012330:RNA, Double-Stranded / Q000187:drug effects; D012367:RNA, Viral / Q000187:drug effects; D013329:Structure-Activity Relationship
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D004277:DNA, Single-Stranded; D004279:DNA, Viral; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C004977:rhodomycin
Sviaz' mezhdu strukturoĭ i deĭstviem antibiotikov rodomitsinovoĭ gruppy na tormoznuiu kinetiku DNK- i RNK-virusov odnospiral'nogo i dvukhspiral'nogo tipov.