title: Critical and controlled tests of activity of a macrocyclic lactone (compound F28249-alpha) against natural infections in internal parasites of equids.
abstract: Thirteen critical tests (n = 11 horses and 2 ponies) and 4 controlled tests (n = 4 donkeys and 6 horses) were performed to evaluate the activity of the experimental macrocyclic lactone compound F28249-alpha against internal parasites of equids. In the critical tests, activity was determined mainly against the large parasites, but 1 critical test also included benzimidazole-resistant small strongyles. In the controlled tests, evaluation of drug activity included large parasites and stomach worms in all 4 tests, and lungworms in 2 tests. The period between treatment and euthanasia was 6 to 9 days for the critical tests and 14, 17, or 52 days for the controlled tests. The compound was administered by stomach tube at dose rates of 1, 2, 3, 3.5, or 4 mg/kg of body weight. In the critical tests, removal at all 5 dose rates was 100% for Gasterophilus nasalis (2nd and 3rd instars), Parascaris equorum (mature), Strongylus vulgaris, and Strongulus edentatus from the gastrointestinal tract. For Gasterophilus intestinalis in the stomach, mean removals of 2nd instars were 88% at the rate of 2 mg/kg and 93% to 100% at rates greater than or equal to 3 mg/kg. For 3rd instars, mean removals were 7% at 1 mg/kg, 77% at 2 mg/kg, 90% at 3 mg/kg, and 98% at 3.5 mg/kg. Discharge of G intestinalis in feces was typically a slow, prolonged process and probably higher removal values, especially at lower dose rates, would have attended a longer interval after treatment before necropsy examination.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Veterinary Science, University of Kentucky, Lexington 40546-0099.
authors.forename: E T
authors.initials: ET
authors.lastname: Lyons
authors.forename: J H
authors.initials: JH
authors.lastname: Drudge
authors.forename: S C
authors.initials: SC
authors.lastname: Tolliver
mesh_terms: D000009:Abdominal Muscles / Q000469:parasitology; D000818:Animals; D000900:Anti-Bacterial Agents; D004175:Diptera / Q000187:drug effects; D005123:Eye / Q000469:parasitology; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007783:Lactones / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects; D008168:Lung / Q000469:parasitology; D018942:Macrolides; D008297:Male; D010271:Parasites / Q000187:drug effects*; D010272:Parasitic Diseases / Q000188:drug therapy / Q000469:parasitology; D010273:Parasitic Diseases, Animal; D010527:Perissodactyla / Q000469:parasitology*; D013320:Strongyloidea / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C056041:nemadectin