title: A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease.
abstract: A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.
authors.affiliation: Johns Hopkins Oncology Center, Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland 21205.
authors.forename: S P
authors.initials: SP
authors.lastname: Staal
authors.forename: R
authors.initials: R
authors.lastname: Ambinder
authors.forename: W E
authors.initials: WE
authors.lastname: Beschorner
authors.forename: G S
authors.initials: GS
authors.lastname: Hayward
authors.forename: R
authors.initials: R
authors.lastname: Mann
mesh_terms: D015139:Blotting, Southern; D004279:DNA, Viral / Q000302:isolation & purification*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000382:microbiology*; D006801:Humans; D008221:Lymphoid Tissue / Q000382:microbiology*
chemical_list: D004279:DNA, Viral