Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells.
The potential of nonterminal cellular differentiation to stably repress the expression of the neoplastic phenotype of transformed cells is established. Nonterminal differentiation induces spontaneously transformed 3T3 T cells to revert to a nontransformed state and induces the revertant cell clones to become resistant to retransformation by UV irradiation or 4-nitroquinoline oxide treatment. Nonterminal differentiation also induces simian virus 40-transformed 3T3 T cells to repress expression of the large tumor antigen and to revert to a nontransformed state. Although the molecular mechanisms that mediate these and other forms of anticancer activity have not been definitively established, data are presented which suggest that differentiation-induced repression of large tumor antigen expression can be regulated at the level of transcription and/or RNA processing.
Scott
R E
RE
Section of Experimental Pathology, Mayo Clinic/Foundation, Rochester, MN 55905.
Estervig
D N
DN
Tzen
C Y
CY
Minoo
P
P
Maercklein
P B
PB
Hoerl
B J
BJ
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002999:Clone Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D013539:Simian virus 40 / Q000235:genetics*