HLA and allopurinol drug eruption.
Strong HLA associations were found in Southern Chinese patients with skin eruptions due to allopurinol. The positive associations were with AW33 (Pc = 1.7 x 10(-5); relative risk [RR] = 15.0, 95% confidence limit 5.2-42.9) with B17/BW58 (Pc = 2.9 x 10(-9); RR = 46.3, 95% confidence limit 10.3-209.2). The negative association was with A2 (Pc = 8.3 x 10(-5), RR = 0). The findings suggested a genetic predisposition to cutaneous drug reactions.
Chan
S H
SH
WHO Immunology Centre, Faculty of Medicine, National University of Singapore.
Tan
T
T
D000493:Allopurinol / Q000009:adverse effects*; D002681:China; D003875:Drug Eruptions / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans
D006680:HLA Antigens; D000493:Allopurinol