Comparative studies on catecholamine content and glycogen phosphorylase activity in the myocardium of spontaneously hypertensive and normotensive rats.
Myocardial noradrenaline (NA) and adrenaline (A) concentrations as well as phosphorylase (PHOS) activity in spontaneously hypertensive (SHR) and normotensive Wistar (NWR) rats 1.5, 3, 6, 12 and 18 months of age were assayed. Myocardial hypertrophy as determined by the heart/body weight ratio in 1.5 month old SHR preceded the onset of hypertension. The arterial blood pressure (ABP) of SHR was significantly elevated from month 3 onward attaining a maximum level at month 12. The concentrations of A and NA, and activity of PHOS "a" in SHR were lower than in NWR between months 3 and 12. The differences were marked in SHR 3 months of age, and corresponded to the ABP changes. An age-dependent decrease in A, NA and PHOS "a" in SHR was observed. The data suggest a role of catecholamines in the development of cardiac hypertrophy via regulation of metabolism.
Ilieva
T
T
Department of Pathophysiology, Medico-Biological Research Institute, Sofia, Bulgaria.
Petkova
I
I
Popova
N
N
Kiprov
D
D
Tsoncheva
A
A
D000375:Aging / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D006005:Phosphorylases; D009638:Norepinephrine; D004837:Epinephrine