title: [Monitoring of renal grafts. Value of the determination of serum neopterin and neopterin versus creatinine ratio].
abstract: In a longitudinal study, 53 renal allograft recipients were investigated for changes in serum creatinine and neopterin levels and in the neopterin/creatinine (N/C) ratio which makes it possible to disregard the glomerular filtration level. The patients were divided into 5 groups according to their clinical situation: stability, acute renal failure due to acute tubular necrosis, acute graft rejection, bacterial or viral infection and cyclosporin overdosage. Only N/C discriminated between these situations, being normal (less than 200.10(-6) in groups 1 and 2, significantly elevated in groups 3 and 4 and low in group 5. The highest N/C value was observed in patients with primary cytomegalovirus infection. It is concluded that the N/C ratio is a good biochemical parameter to be used in the follow-up of renal allograft recipients.
authors.affiliation: Service de Néphrologie, CHU de Saint-Etienne, Hôpital Nord, Saint-Priest-en-Jarez.
authors.forename: J
authors.initials: J
authors.lastname: Hacini
authors.forename: P
authors.initials: P
authors.lastname: Berthoux
authors.forename: C
authors.initials: C
authors.lastname: Guerin
authors.forename: G
authors.initials: G
authors.lastname: Charrere
authors.forename: G
authors.initials: G
authors.lastname: Ville
authors.forename: F C
authors.initials: FC
authors.lastname: Berthoux
mesh_terms: D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D001708:Biopterins; D019798:Neopterin; D003404:Creatinine
vernacular_title: Surveillance des greffes rénales. Intérêt du dosage de la néoptérine sérique et du rapport sérique néoptérine sur créatinine.