title: [Physicochemical and functional properties of the peripheral blood lymphocytes in ischemic heart disease].
abstract: Electron spin resonance techniques was used for the investigation of the structural organization of lymphocyte plasma membranes of healthy donors and IHD patients. We found the increased fluidity of peripheral blood lymphocyte membranes of patients with IHD using 5 doxyl stearic acid spin label. The ordering of the membrane lipids increased proportionally to the increase of cholesterol cell content. This is the important reason for the inhibition of mitogenic cell activity during IHD. Measured by the chlortetracycline-fluorescence alterations in the processes of mitogen-induced Ca+2 redistribution might be one of the mechanisms which mediates the influence of membrane structure changes on the lymphocyte functions.
authors.forename: E A
authors.initials: EA
authors.lastname: Gorbatenkova
authors.forename: O A
authors.initials: OA
authors.lastname: Azizova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Vladimirov
mesh_terms: D002118:Calcium / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003208:Concanavalin A / Q000494:pharmacology; D003327:Coronary Disease / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D003208:Concanavalin A; D002118:Calcium
vernacular_title: Fiziko-khimicheskie i funktsional'nye svoĭstva limfotsitov perifericheskoĭ krovi pri ishemicheskoĭ bolezni serdtsa.