title: [Model antigens and their significance for occupational dermatology].
abstract: By means of epicutaneous tests we studied the contact hypersensitivity to DNP-amino acids in individuals sensitized to dinitrochlorobenzene (DNCB). We found a high incidence of positive skin responses to DNP-glycine, di-DNP-L-cystine, and DNP-L-alpha-alanine, but only in some cases DNP-beta-alanine induced skin reactivity. The results are discussed both in connection with the influence of varying molecular sizes and chemical structure on the immunological reactivity and the possibility to develop a beta-alanine containing protective ointment against protein-reactive haptens.
authors.forename: G
authors.initials: G
authors.lastname: Schwartze
authors.forename: D
authors.initials: D
authors.lastname: Lübbe
authors.forename: K D
authors.initials: KD
authors.lastname: Wozniak
mesh_terms: D000941:Antigens; D003877:Dermatitis, Contact / Q000175:diagnosis*; D009783:Dermatitis, Occupational / Q000175:diagnosis*; D004137:Dinitrochlorobenzene; D004140:Dinitrophenols; D006801:Humans; D010328:Patch Tests / Q000379:methods*; D012882:Skin Tests / Q000379:methods*
chemical_list: D000941:Antigens; D004137:Dinitrochlorobenzene; D004140:Dinitrophenols
vernacular_title: Modellantigene und ihre Bedeutung für die Arbeitsdermatologie.