Hyperkalemic periodic paralysis in Gordon's syndrome: a possible defect in atrial natriuretic peptide function.
We present the case of a 14-year-old boy who had secondary hyperkalemic periodic paralysis caused by Gordon's syndrome. This syndrome consists of hypertension, tubular acidosis, and hyperkalemia with normal glomerular filtration rate. The pathophysiological mechanism is still unknown. Pathophysiological studies suggest that in this disorder the kidney lacks sensitivity to atrial natriuretic peptide. After treatment with hydrochlorothiazide, serum potassium and plasma aldosterone values, plasma renin activity, and blood pressure became normal and the attacks of periodic paralysis disappeared.
Pasman
J W
JW
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
Gabreëls
F J
FJ
Semmekrot
B
B
Renier
W O
WO
Monnens
L A
LA
D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000097:blood*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006947:Hyperkalemia / Q000150:complications*; D006973:Hypertension / Q000150:complications*; D008297:Male; D010243:Paralysis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D013577:Syndrome
D006852:Hydrochlorothiazide; D009320:Atrial Natriuretic Factor