Translocation of the MOS gene in a rare t(8;16) associated with acute myeloblastic leukemia and Down syndrome.
Cytogenetic analysis of an infant with Down syndrome with concomitant acute myelogenous leukemia revealed a unique t(8;16)(q22;q24). In situ chromosomal hybridization was used to demonstrate that the protooncogene MOS was translocated from chromosome 8 to chromosome 16. This is the first report of the transposition of MOS in association with acute leukemia.
Pettenati
M J
MJ
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
McNay
J W
JW
Chauvenet
A R
AR
D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D014178:Translocation, Genetic