title: On-line synthesis of [11C]nitroalkanes.
abstract: The on-line synthesis of 1-11C-labelled nitroalkanes [nitromethane (I), nitroethane (II) and nitropropane (III)], from their corresponding 1-11C-labelled alkyl iodides, by use of a heated silver nitrite column is described. The radiochemical yields of I, II and III were of the order of 40-70%, based on the corresponding [1-11C]alkyl iodides. The total radiochemical yields, starting from [11C]carbon dioxide, were of the order of 25-55% with an overall synthesis time of 8-15 min.
authors.affiliation: Karolinska Pharmacy, Stockholm, Sweden.
authors.forename: K O
authors.initials: KO
authors.lastname: Schoeps
authors.forename: S
authors.initials: S
authors.lastname: Stone-Elander
authors.forename: C
authors.initials: C
authors.lastname: Halldin
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes; D004980:Ethane / Q000031:analogs & derivatives; D008697:Methane / Q000031:analogs & derivatives; D009595:Nitroparaffins / Q000138:chemical synthesis*; D011407:Propane / Q000031:analogs & derivatives
chemical_list: D000473:Alkanes; D002250:Carbon Radioisotopes; D009595:Nitroparaffins; D004980:Ethane; D008697:Methane; D011407:Propane