Effect of ampicillin on neuromuscular transmission in healthy men: a single-fiber electromyographic study.
Ampicillin is considered a 'safe' drug in patients with neuromuscular transmission disorders although recently some doubt has been raised. The effect of ampicillin on neuromuscular transmission was studied in healthy subjects by means of single-fiber electromyography. A statistically significant increase of mean jitter value and of recordings with abnormally high jitter occurred after ampicillin treatment in comparison to basal examinations. Such results reaffirm that ampicillin might not be completely harmless in patients with neuromuscular transmission disturbances.
Girlanda
P
P
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
Venuto
C
C
Mangiapane
R
R
D000328:Adult; D000667:Ampicillin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
D000667:Ampicillin