Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain.
CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.
Wright
A
A
Department of Pediatrics, Stanford University School of Medicine, California 94305.
Lee
J E
JE
Link
M P
MP
Smith
S D
SD
Carroll
W
W
Levy
R
R
Clayberger
C
C
Krensky
A M
AM
D000293:Adolescent; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002051:Burkitt Lymphoma / Q000276:immunology*; D017252:CD3 Complex; D016827:CD8 Antigens; D002461:Cell Line, Transformed; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen; D004854:Herpesvirus 4, Human; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D007130:Immunoglobulin Idiotypes; D016169:Lymphocyte Function-Associated Antigen-1; D011948:Receptors, Antigen, T-Cell