title: [Primary hyperparathyroidism disclosed by heart arrhythmia].
abstract: The authors report a case of primary hyperparathyroidism in a 47 year old woman presenting with cardiac arrhythmias. She had paraoxystic supraventricular tachycardias and rate-dependent ventricular hyperexcitability suggestive of a catecholamine-induced phenomenon which were resistant to antiarrhythmic therapy over a 3 year period; the plasma calcium concentration was 3.30 mmol/l. An ectopic parathyroid adenoma was removed surgically, normalising the biological changes, and no further arrhythmias were detected by Holter monitoring during the 2 year follow-up period. The association of atrial and ventricular arrhythmias seems to be relatively rate in hyperparathyroidism; patients usually present with atrioventricular block and ventricular hyperexcitability. The other cardiovascular abnormalities observed in hyperparathyroidism are hypertension and myocardial hypertrophy. The electrophysiological mechanisms underlying the clinical manifestations remain obscure.
authors.affiliation: Service de cardiologie, hôpital Bichat, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: P
authors.initials: P
authors.lastname: Charlier
authors.forename: A C
authors.initials: AC
authors.lastname: Solal
authors.forename: P
authors.initials: P
authors.lastname: Passa
authors.forename: R
authors.initials: R
authors.lastname: Gourgon
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged
vernacular_title: Hyperparathyroïdie primitive révélée par des troubles du rythme cardiaque.