title: A comparison of radial, brachial, and aortic pressures after cardiopulmonary bypass.
abstract: Previous investigations have identified falsely low radial artery pressures after cardiopulmonary bypass (CPB). The present study investigates the relationship among radial, brachial, and aortic arterial pressures in 33 cardiac surgical patients following CPB. Two minutes after separation from CPB, clinically important (greater than or equal to 10 mmHg) underestimation of systolic aortic pressures occurred in 17 of 33 (52%) radial artery catheters, while occurring in seven of 33 (21%) brachial artery catheters. Radial artery mean pressure underestimated aortic mean pressure by greater than or equal to 5 mmHg in 21 of 33 (61%) patients two minutes after CPB, while an equivalent aortic-to-brachial artery mean arterial pressure difference occurred in nine of 33 (27%) patients. The incidence of aortic-to-radial mean arterial pressure differences greater than or equal to 5 mmHg decreased to 40% (four of ten patients) by ten minutes after CPB, although interpretation is complicated by decreased availability of aortic pressure measurements. Multivariate analysis failed to identify factors predisposed to central-to-peripheral pressure gradients. Radial and brachial arterial pressures were compared both before and after CPB in all 33 patients. Brachial artery systolic and mean pressures were higher than corresponding radial artery measurements two minutes after CPB (P less than 0.05), followed by gradual resumption of a normal brachial-to-radial pressure relationship over 60 minutes. Either vasospasm in the brachial and radial arteries or profound arteriolar vasodilation in the upper extremity might cause the observed central-to-peripheral arterial pressure differences. The progressive central-to-peripheral decrease in mean arterial pressure favors the latter mechanism.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
authors.forename: G P
authors.initials: GP
authors.lastname: Gravlee
authors.forename: A B
authors.initials: AB
authors.lastname: Wong
authors.forename: T G
authors.initials: TG
authors.lastname: Adkins
authors.forename: L D
authors.initials: LD
authors.lastname: Case
authors.forename: A L
authors.initials: AL
authors.lastname: Pauca
mesh_terms: D000328:Adult; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology*; D006328:Cardiac Catheterization; D002315:Cardiopulmonary Bypass; D006801:Humans; D008875:Middle Aged; D009599:Nitroprusside / Q000627:therapeutic use; D011884:Radius / Q000098:blood supply*; D013599:Systole; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009599:Nitroprusside