title: [The ACTH and cortisol content of the blood in experimental focal epilepsy].
abstract: In experiments on 87 freely behaving rats and 7 cats treated with d-tubocurarine and anesthetized with nembutal it was established that the generation of focus of epileptic activity (EA) in cerebral cortex by surface application of sodium benzylpenicillin is accompanied by an increase in the plasma level of ACTH (2-fold in rats and 2.5-fold in cats) with consequent rise in the plasma cortisol level (1.5-fold both in rats and cats). In cats a "delayed" rise in plasma ACTH was observed after the cessation of cortical EA. The described changes in plasma ACTH are a result of the pathological hyperactivity of neurons rather then a stressor component under the EA.
authors.forename: T V
authors.initials: TV
authors.lastname: Goriacheva
authors.forename: M N
authors.initials: MN
authors.lastname: Karpova
authors.forename: R N
authors.initials: RN
authors.lastname: Glebov
authors.forename: I O
authors.initials: IO
authors.lastname: Mikhal'skaia
authors.forename: M E
authors.initials: ME
authors.lastname: Kislova
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D002415:Cats; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010400:Penicillin G; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000324:Adrenocorticotropic Hormone; D010400:Penicillin G; D006854:Hydrocortisone
vernacular_title: Soderzhanie AKTG i kortizola v krovi pri éksperimental'noĭ ochagovoĭ épilepsii.