Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma.
The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymphocytes were available, a histiocytic origin of such neoplasms had been suggested. A panel of antibodies reactive with most B cells (L26, MB1, KiB3) and a majority of T cells (MT1, UCHL1) was applied on paraffin sections of formalin fixed tissues as well as antibodies directed against leukocyte common antigen (LCA), myeloid/histiocyte antigen (MAC 387), lysozyme, alpha-1-antitrypsin, alpha-1-antichymotrypsin, S-100 protein, prekeratin and immunoglobulin light chains. Enzyme histochemistry included tests for non-specific acid esterase, acid phosphatase, beta-glucuronidase and chloroacetate esterase. As a result, five T, two B and two unclassified (malignant histiocytosis probable) NHL were identified, indicating distinct heterogeneity of NHL as causative disorders in lethal midline granuloma.
Laeng
R H
RH
Department of Pathology, University of Bern, Switzerland.
Gerber
H A
HA
Schaffner
T
T
Bürki
K H
KH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000943:Antigens, Differentiation / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006103:Granuloma, Lethal Midline / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006649:Histocompatibility Antigens / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D009418:S100 Proteins; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D017493:Leukocyte Common Antigens