title: Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?
abstract: A 43-year-old man underwent abdominoperineal resection of a rectal adenocarcinoma, and left hepatic lobectomy for a single metastasis. He then received hepatic artery infusions of floxuridine. The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation. In the hilus of the native liver, obstructive arteriopathy and portal venopathy were found. These lesions probably had been caused by drug-induced intravascular thrombosis. Thus, the sclerosing cholangitis that develops in many patients after floxuridine infusion may be ischemic rather than toxic. The patient described here is well, 14 months after orthotopic liver transplantation. Therefore, in some cases of floxuridine-induced cholangitis, liver transplantation appears to be indicated despite a history of metastasizing carcinoma.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
authors.forename: C H
authors.initials: CH
authors.lastname: Kim
authors.forename: R H
authors.initials: RH
authors.lastname: Wiesner
authors.forename: R A
authors.initials: RA
authors.lastname: Krom
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000098:blood supply*; D015209:Cholangitis, Sclerosing / Q000139:chemically induced* / Q000473:pathology; D005467:Floxuridine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D012004:Rectal Neoplasms / Q000601:surgery
chemical_list: D005467:Floxuridine