title: Effects of fluoxetine upon pharmacoendocrine and sleep-EEG parameters in normal controls.
abstract: A single dose of 80 mg fluoxetine induced a slight increase in cortisol secretion when compared to placebo in an acute endocrine challenge test including assessment of prolactin, growth hormone, luteinizing hormone, follicle stimulating hormone, testosterone. This pretreatment with 80 mg fluoxetine did not change the ACTH release after blockade of the feed-back regulation of peripheral corticosteroids on ACTH secretion by metyrapone. Sleep-EEG revealed reduction of rapid-eye-movement sleep. Nocturnal penile tumescence activity was unaltered.
authors.affiliation: Department of Psychiatry, University of Freiburg, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: von Bardeleben
authors.forename: A
authors.initials: A
authors.lastname: Steiger
authors.forename: A
authors.initials: A
authors.lastname: Gerken
authors.forename: F
authors.initials: F
authors.lastname: Holsboer
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D003350:Cortodoxone / Q000378:metabolism; D004569:Electroencephalography; D005473:Fluoxetine / Q000494:pharmacology*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D010410:Penile Erection / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D006728:Hormones; D005473:Fluoxetine; D000324:Adrenocorticotropic Hormone; D003350:Cortodoxone; D006854:Hydrocortisone; D008797:Metyrapone