title: On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon.
abstract: The results of the segregation analysis of hereditary adenomatous polyposis and primary cancer of the colon are given, taking into account the age-dependent manifestation of genotypes and the specificity of pedigree sampling. The results are used for testing the hypothesis of pleiotropic monogenic control of these two colon pathologies.
authors.affiliation: Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk.
authors.forename: E K
authors.initials: EK
authors.lastname: Ginsburg
authors.forename: T I
authors.initials: TI
authors.lastname: Axenovich
authors.forename: B A
authors.initials: BA
authors.lastname: Altshouler
authors.forename: M D
authors.initials: MD
authors.lastname: Bazhenova
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003110:Colonic Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D010375:Pedigree; D011336:Probability