[Chronic diarrhea as a clinical expression of common variable hypogammaglobulinemia: apropos of 3 cases].
Sixty per cent of the patients with immuno-compromise of the humoral compartment may show chronic diarrhoea, specially seen in the common variable hypogammaglobulinemia (CVH). We presented 3 cases of late-onset CVH who referred chronic diarrhoea as the main symptom. The immunodiagnosis revealed undetectable or subnormal immunoglobulins levels (G, M, A), preserved total haemolytic complement and a negative autoimmune screening. The cell compartment analysis showed increased number of suppressor T lymphocytes (CD8) plus hyporesponsiveness of the total peripheral lymphocytes to polyclonal mitogens such PHA. The clinical approach of the CVH patients should be performed by a multispecialized team including the clinical immunologist and the gastrointestinal and infectious diseases specialists.
Aldrey
O
O
Müller
G
G
Olaria
T
T
Deibis
L
L
Zabaleta
M
M
Quijada
L
L
Machado
I
I
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D000917:Antibody Formation; D002908:Chronic Disease; D015941:Complement Hemolytic Activity Assay; D003967:Diarrhea / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D013601:T-Lymphocytes / Q000032:analysis
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Diarrea crónica como expresión clínica de la hipogammaglobulinemia común variable. A propósito de 3 casos.