title: The bioavailability of three altretamine formulations.
abstract: The bioavailability of two altretamine preparations was studied in a randomized cross-over design. The two preparations were compared with a third in a parallel design. Dissolution differences between the preparations were observed, which could give rise to differences in bioavailability caused by the extensive first-pass effect of altretamine. The in vivo data showed a trend to differences in bioavailability.
authors.affiliation: Röpcke-Zweers Hospital, Hardenberg, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Runhaar
authors.forename: J P
authors.initials: JP
authors.lastname: Neijt
authors.forename: J J
authors.initials: JJ
authors.lastname: Holthuis
authors.forename: D
authors.initials: D
authors.lastname: de Vos
mesh_terms: D000328:Adult; D000368:Aged; D006585:Altretamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002849:Chromatography, Gas; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D012995:Solubility; D014227:Triazines / Q000493:pharmacokinetics*
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; D006585:Altretamine