Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery.
The authors conducted a sleep-endocrine evaluation among 10 unmedicated male patients with major endogenous depression during their depressive episode and following full clinical remission and drug withdrawal. While abnormally high values for cortisol secretory activity normalized after return to euthymia, growth hormone release and characteristic disturbances of EEG sleep remained unchanged. Whether or not neuroendocrine and sleep EEG abnormalities, which are present in remission, are trait markers remains undecided until premorbid sleep-endocrine data are available.
Steiger
A
A
Department of Psychiatry, University of Mainz, F.R.G.
von Bardeleben
U
U
Herth
T
T
Holsboer
F
F
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D004569:Electroencephalography; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology
D000928:Antidepressive Agents; D013006:Growth Hormone; D006854:Hydrocortisone