title: IgE receptors from rat intestinal mucosal and peritoneal mast cells show mast cell subtype-specific differences.
abstract: High- (alpha chain) and low-affinity IgE receptors from purified populations of rat intestinal mucosal (IMMC) and peritoneal mast cells (PMC) were characterized by SDS-PAGE. Receptor expression and molecular weight were compared. IMMC yielded 59-kilodalton (kDa) alpha chains of the high-affinity receptors and two forms (58, 50 kDa) of low-affinity receptors, whereas PMC possessed only 51-kDa alpha chains and 56-kDa low-affinity receptors. These differences extend the evidence for functional diversity between mast cell subtypes.
authors.affiliation: Immunological Sciences Research Group, University of Calgary, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Swieter
authors.forename: B M
authors.initials: BM
authors.lastname: Chan
authors.forename: T D
authors.initials: TD
authors.lastname: Lee
authors.forename: C J
authors.initials: CJ
authors.lastname: Rimmer
authors.forename: A
authors.initials: A
authors.lastname: Froese
authors.forename: D
authors.initials: D
authors.lastname: Befus
mesh_terms: D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000145:classification / Q000378:metabolism*; D007073:Immunoglobulin E / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology; D008407:Mast Cells / Q000145:classification / Q000378:metabolism*; D008970:Molecular Weight; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011961:Receptors, Fc / Q000145:classification / Q000378:metabolism*; D017455:Receptors, IgE
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E