title: Time course of serum amyloid A response in myocardial infarction.
abstract: Plasma concentrations of serum amyloid A (SAA), high density lipoprotein (HDL) cholesterol, non-HDL cholesterol, and apolipoproteins (Apo) A-I and B were measured daily for 6 days in 10 patients following myocardial infarction (MI) and in 10 secular controls admitted to a coronary care unit. SAA concentrations peaked 3 days following MI (mean 47 mg/dl) and correlated with creatine kinase (CK) (r = 0.67, P less than 0.001). Non-HDL cholesterol and Apo B fell 15 and 18%, respectively, reached nadirs 3-4 days after MI and were inversely related to CK concentrations (P less than 0.01 for both). HDL cholesterol levels, in contrast, increased 15% and were significantly higher than baseline by day 3 when SAA concentrations were maximum. HDL cholesterol subsequently fell in parallel with SAA and had returned to baseline by day 6. Apo A-I declined throughout the 6 days of observation and was 13% lower than initial values on day 6 (P less than 0.05). The Apo A-I reduction was inversely related to both CK and SAA concentrations. There were no significant changes in any of the analytes in control subjects. We conclude that Apo A-I and possibly Apo B containing lipoproteins are negative acute phase reactants. HDL cholesterol is transiently elevated after MI despite decreasing Apo A-I levels and this may relate to incorporation of SAA into HDL particles.
authors.affiliation: Department of Medicine, Miriam Hospital, Brown University, Providence, RI 02906.
authors.forename: L L
authors.initials: LL
authors.lastname: Bausserman
authors.forename: A
authors.initials: A
authors.lastname: Sadaniantz
authors.forename: A L
authors.initials: AL
authors.lastname: Saritelli
authors.forename: V L
authors.initials: VL
authors.lastname: Martin
authors.forename: A M
authors.initials: AM
authors.lastname: Nugent
authors.forename: S P
authors.initials: SP
authors.lastname: Sady
authors.forename: P N
authors.initials: PN
authors.lastname: Herbert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D000685:Serum Amyloid A Protein; D002784:Cholesterol