title: The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin.
abstract: This review is intended to describe the characteristics of the rat models of non-insulin-dependent diabetes induced by neonatal streptozotocin administration (n-STZ models), to sum-up the information so far collected and to highlight the potential of these models for diabetes research. The n-STZ models can now be recognized as adequate tools for the elucidation of the mechanisms leading to: 1) regeneration of the beta cells, 2) the functional "exhaustion" of the beta cells, 3) the emergence of defects in insulin action. They appear well-suited to study the effects of the modulating factors involved in the appearance and/or deterioration of non-insulin-dependent diabetes (obesity, gestation, content of the diet). They are potentially appropriate for investigations in diabetes pharmacotherapy.
authors.affiliation: Laboratoire de Physiologie du Développement, CNRS UA 307, Université Paris.
authors.forename: B
authors.initials: B
authors.lastname: Portha
authors.forename: O
authors.initials: O
authors.lastname: Blondel
authors.forename: P
authors.initials: P
authors.lastname: Serradas
authors.forename: R
authors.initials: R
authors.lastname: McEvoy
authors.forename: M H
authors.initials: MH
authors.lastname: Giroix
authors.forename: M
authors.initials: M
authors.lastname: Kergoat
authors.forename: D
authors.initials: D
authors.lastname: Bailbe
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage
chemical_list: D013311:Streptozocin