Gonadotropin-releasing hormone agonist analog therapy effective in ovarian granulosa cell malignancy.
Ovarian granulosa cell tumor lung metastases regressed, and symptoms were relieved, during gonadotropin-releasing hormone (GnRH) agonist analog therapy after the failure of operative treatment and cytotoxic chemotherapy, indicating the hormone dependence of the malignancy. The response was transient, but the largest metastasis did not relapse. This case report suggests that GnRH analogs may offer a new approach to the treatment of ovarian stromal cell malignancies.
Martikainen
H
H
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Penttinen
J
J
Huhtaniemi
I
I
Kauppila
A
A
D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D017273:Goserelin; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010906:Pituitary Hormone-Releasing Hormones / Q000502:physiology
D010906:Pituitary Hormone-Releasing Hormones; D017273:Goserelin; D002064:Buserelin