Modification of the behavioural effects of amineptine after acute, subacute and chronic administration of phenobarbital in mice.
In an open-field test, mice that were given an acute treatment with 20 mg/kg ip phenobarbital and/or 10-20 mg/kg ip amineptine showed an increase in locomotor activity and rearing. Tolerance to the subacute or chronic effects of phenobarbital, but not to those of amineptine, was found. After subacute or chronic treatment with phenobarbital in association with amineptine, a significant decrease in the stimulating effect of amineptine was observed, as compared to single or associated acute treatments. These data demonstrate that, after subacute or chronic administration of phenobarbital and amineptine, an interaction occurs, and they outline the importance of enzyme induction in the metabolism of amineptine.
De Angelis
L
L
Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università di Trieste, Italy.
D000374:Aggression / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology*; D012016:Reference Values
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011597:amineptin; D010634:Phenobarbital