[The role of the active center of the enzyme in the triggering mechanism of the compensatory reaction to plasmin].
The participation of plasmin active site in the trigger's mechanisms of the compensatory reaction of haemostasis system on this enzyme was studied in the experiments on white rats and rabbits using intravenous injection and perfusion of the humorally isolated carotid sinus are with intact innervation. Native enzyme, the enzyme with reversibly (acylated plasmin) and irreversibly (diisopropylphosphoryl plasmin) blocked active site were used. It was ascertained that the development of the compensatory reaction of haemostasis system on plasmin, manifested by hypercoagulation and depression of fibrinolysis, is conditioned by the proteolytic activation of the vascular wall receptors.
Kalishevskaia
T M
TM
Golubeva
M G
MG
Aĭsina
R B
RB
Popova
G Iu
GIu
Bashkov
G V
GV
D000215:Acylation; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007531:Isoflurophate / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
D007531:Isoflurophate; D005341:Fibrinolysin
Rol' aktivnogo tsentra fermenta v trigernom mekhanizme kompensatornoĭ reaktsii na plazmin.