title: High-grade atrioventricular heart block in an adult with systemic lupus erythematosus: the association of nuclear RNP (U1 RNP) antibodies, a case report, and review of the literature.
abstract: High-grade atrioventricular heart block (HGAVB) occurring as a manifestation of systemic lupus erythematosus is an exceedingly rare event. We describe a patient with HGAVB who had myositis and antibodies to nuclear RNP (previously associated with myocarditis). A review of the literature on HGAVB associated with systemic lupus erythematosus is also presented.
authors.affiliation: Department of Internal Medicine, Johns Hopkins School of Medicine and Hospital, Baltimore, Maryland 21205.
authors.forename: S D
authors.initials: SD
authors.lastname: Bilazarian
authors.forename: A J
authors.initials: AJ
authors.lastname: Taylor
authors.forename: D
authors.initials: D
authors.lastname: Brezinski
authors.forename: M C
authors.initials: MC
authors.lastname: Hochberg
authors.forename: T
authors.initials: T
authors.lastname: Guarnieri
authors.forename: T T
authors.initials: TT
authors.lastname: Provost
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006327:Heart Block / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D009220:Myositis / Q000150:complications / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D017411:Ribonucleoproteins, Small Nuclear
chemical_list: D000974:Antibodies, Antinuclear; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear