The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver.
The effect of blockade of calcium channels and/or 5-HT receptors on the hepatic lodgement of intraportally injected fibrosarcoma cells was studied in rats. The calcium channel blocker verapamil and the 5-HT2 antagonist ketanserin each had a significant lodgement reducing effect. The pure 5-HT2 antagonist R 56413 was most effective and dose-dependent in its tumour cell lodgement reducing effect. At the highest dose tested (2.5 mg/kg body weight) R 56413 was as effective as thrombocytopenia, indicating that 5-HT is the most important platelet-released product that influences tumour cell lodgement.
Skolnik
G
G
Department of Surgery I, University of Göteborg, Sweden.
Bagge
U
U
Blomqvist
G
G
Djärv
L
L
Ahlman
H
H
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology*; D007650:Ketanserin / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology
D015220:Calcium Channels; D010880:Piperidines; D011985:Receptors, Serotonin; C046301:seganserin; D007650:Ketanserin; D014700:Verapamil