title: [Preventive treatment of infection caused by gram-negative bacteria using anti-lipopolysaccharide antibodies. Evaluation in patients with aplasia].
abstract: The prophylaxis of severe Gram-negative infections with human antiserum to lipopolysaccharide (LPS) was evaluated in a randomised study of 60 patients with therapeutic aplasia for leukaemia. The antiserum was found to be ineffective in preventing Gram-negative infections. The levels of anti-LPS antibodies showed that passive immunization was obtained in only one half of the patients. These disappointing results warrant further investigations to evaluate the effectiveness of this prophylactic treatment.
authors.affiliation: Laboratoire de Bactériologie, Hôtel Dieu, Rouen.
authors.forename: F
authors.initials: F
authors.lastname: Lecomte
authors.forename: H
authors.initials: H
authors.lastname: Tilly
authors.forename: G
authors.initials: G
authors.lastname: Grise
authors.forename: D
authors.initials: D
authors.lastname: Bastit
authors.forename: C
authors.initials: C
authors.lastname: Ropartz
authors.forename: J F
authors.initials: JF
authors.lastname: Lemeland
authors.forename: G
authors.initials: G
authors.lastname: Humbert
authors.forename: M
authors.initials: M
authors.lastname: Monoconduit
authors.forename: H
authors.initials: H
authors.lastname: Piguet
mesh_terms: D000328:Adult; D000380:Agranulocytosis; D000906:Antibodies / Q000032:analysis / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D007116:Immunization, Passive / Q000379:methods; D007136:Immunoglobulins; D007938:Leukemia / Q000188:drug therapy; D008070:Lipopolysaccharides / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009503:Neutropenia; D011897:Random Allocation
chemical_list: D000906:Antibodies; D007136:Immunoglobulins; D008070:Lipopolysaccharides; C042866:antilipopolysaccharide antibodies
vernacular_title: Traitement préventif des infections à bacille à Gram négatif par des anticorps anti-lipopolysaccharides. Evaluation chez l'aplasique.