In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.
3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for colony formation of erythroid and granulocytic cells.
Inoue
T
T
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Tsushita
K
K
Itoh
T
T
Ogura
M
M
Hotta
T
T
Saneyoshi
M
M
Yoshida
S
S
Saitoh
H
H
Tomoda
Y
Y
Nagai
Y
Y
D000998:Antiviral Agents / Q000494:pharmacology / Q000633:toxicity*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D003114:Colony-Forming Units Assay; D015224:Dideoxynucleosides / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology / Q000633:toxicity*; D016047:Zalcitabine; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D009705:Nucleosides; D015215:Zidovudine; D016047:Zalcitabine