[Ultrastructural characteristics of the cerebellar cortex in the postnatal development of animals with protein-calorie malnutrition and in subsequent rehabilitation].
An electron microscopical investigation of the cerebellar cortex has been carried out in mice, kept during the 10th-40th days of their life at a diet with protein insufficiency and a subsequent food rehabilitation and food rehabilitation with carnitine addition to the diet on the 41st-70th days of their life. A sharp protein limitation in the diet results in the most essential changes in the neuropil, while the ultrastructure of the piriform neurons changes slightly. Amount of the synaptic vesicles in small axonal terminals decreases and their localization in the area of the synaptic contacts changes. Simultaneously, degeneratively changed axonal terminals often occur, they demonstrate a rather electron opaque axoplasma. The food rehabilitation mainly normalizes the ultrastructure of the cerebellar cortex elements, however, in the neuropil altered axonal terminals with a high electron opaque axoplasma occur. After the food rehabilitation with carnitine addition to the diet, the cerebellar cortex ultrastructure not only normalizes, but even demonstrates certain signs of hypertrophy.
Medvedev
D I
DI
Babichenko
I I
II
Kravtsova
A I
AI
Eremina
I Z
IZ
D000367:Age Factors; D000818:Animals; D001284:Atrophy / Q000209:etiology; D002331:Carnitine / Q000008:administration & dosage*; D002364:Caseins / Q000008:administration & dosage*; D002525:Cerebellar Cortex / Q000473:pathology / Q000648:ultrastructure*; D004044:Dietary Proteins / Q000008:administration & dosage*; D006984:Hypertrophy / Q000209:etiology; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D011502:Protein-Energy Malnutrition / Q000178:diet therapy / Q000473:pathology*
D002364:Caseins; D004044:Dietary Proteins; D002331:Carnitine
Osobennosti u'ltrastruktury kory mozzhechka pri postnata'lnom razvitii zhivotnykh v usloviiakh belkovo-énergeticheskoĭ nedosta- tochnosti i posleduiushcheĭ reabilitatsii.