Modulation of lentivirus replication by antibodies: Fc portion of immunoglobulin molecule is essential for enhancement of binding, internalization, and neutralization of visna virus in macrophages.
Antibodies to visna virus neutralized the virus in fibroblasts and macrophages but specifically enhanced the binding, penetration, and uncoating of the virus in the latter cells. F(ab')2 fragments of the immune antibody neutralized the virus in fibroblasts but did not enhance the early stages of the virus life cycle in macrophages. Furthermore, these fragments did not neutralize infectivity in macrophages but delayed the appearance of infectious virus in cells after the inoculation of preincubated virus-F(ab')2 complexes.
Jolly
P E
PE
Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Huso
D L
DL
Sheffer
D
D
Narayan
O
O
D000818:Animals; D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D009500:Neutralization Tests; D011961:Receptors, Fc / Q000276:immunology; D012756:Sheep; D014779:Virus Replication; D014790:Visna-maedi virus / Q000254:growth & development / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D011961:Receptors, Fc