title: Relationship among transmissible gastroenteritis virus antibody titers in serum, colostrum, and milk from vaccinated sows, and protection in their suckling pigs.
abstract: We studied the antibody responses to transmissible gastroenteritis (TGE) in serum, colostrum, and milk from sows vaccinated with 2 attenuated (1 IM and 1 oral-IM) and 1 nonattenuated live vaccines and the relationship of these responses with the survivability of the sow's suckling pigs after challenge exposure with virulent TGE virus. Contrary to previous studies, the anti-TGE virus-neutralizing geometric mean titers (GMT) in the milk of sows vaccinated with attenuated vaccines at 3 and 5 days of lactation were similar to that found in the colostrum. Colostral and serum antibody titers were highest in sows given 2 injections of the IM attenuated vaccine. Half of the sows given the oral-IM attenuated vaccine did not seroconvert after 2 oral doses. Only sows vaccinated with the nonattenuated live vaccine had milk GMT that remained high for 21 days after farrowing. The linear relationship between colostral GMT and percentage of survivability of suckling pigs challenge exposed at 3 days of age was significant (P less than 0.05), although the relationship between serum GMT and percentage of survivability and the relationship between milk GMT and percentage of survivability were not significant (P greater than 0.10). The linear relationship between colostral (P less than 0.10) or pre-challenge exposure milk (P less than 0.05) GMT and percentage of survivability of suckling pigs challenge exposed at 5 days of age was significant.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211.
authors.forename: R A
authors.initials: RA
authors.lastname: Moxley
authors.forename: L D
authors.initials: LD
authors.lastname: Olson
authors.forename: R F
authors.initials: RF
authors.lastname: Solorzano
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D003126:Colostrum / Q000276:immunology*; D003332:Coronaviridae / Q000276:immunology*; D003907:Dexamethasone; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000517:prevention & control*; D007112:Immunity, Maternally-Acquired; D007978:Levamisole; D008892:Milk / Q000276:immunology*; D011247:Pregnancy; D011897:Random Allocation; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D007978:Levamisole; D003907:Dexamethasone