title: Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome.
abstract: Observations concerning the time course of deposition of amyloid within the brain substance and blood vessels in persons, of different ages, with Down's syndrome are used to provide a perspective on the nature of the process of cerebral amyloidosis in Alzheimer's disease.
authors.affiliation: Department of Pathology, University of Manchester, Great Britain.
authors.forename: D M
authors.initials: DM
authors.lastname: Mann
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000378:metabolism; D016229:Amyloid beta-Peptides; D000686:Amyloidosis / Q000378:metabolism* / Q000473:pathology; D002648:Child; D004314:Down Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008875:Middle Aged
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides