Adenovirus E1A represses transcription of the cellular JE gene.
The expression of the growth factor-inducible JE gene was severely reduced in cells expressing region E1A of human adenoviruses. This reduction was not caused by a decreased stability of JE mRNA but by a reduced transcription rate as determined by run-on transcription experiments. Nevertheless, JE mRNA could still be induced by growth factors, suggesting that intracellular signaling is not blocked but rather that the basal level of JE transcription is repressed by E1A.
Timmers
H T
HT
Laboratory for Molecular Carcinogenesis, Sylvius Laboratories, University of Leiden, The Netherlands.
van Dam
H
H
Pronk
G J
GJ
Bos
J L
JL
Van der Eb
A J
AJ
D017456:Adenovirus Early Proteins; D000818:Animals; D002472:Cell Transformation, Viral; D018932:Chemokine CCL2; D005786:Gene Expression Regulation / Q000187:drug effects; D006023:Glycoproteins / Q000235:genetics*; D006133:Growth Substances / Q000494:pharmacology; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
D017456:Adenovirus Early Proteins; D018932:Chemokine CCL2; D006023:Glycoproteins; D006133:Growth Substances; D009856:Oncogene Proteins, Viral; D012333:RNA, Messenger; D013755:Tetradecanoylphorbol Acetate