title: Stimulation of calcium uptake by norepinephrine or high external potassium in human calyces and renal pelvis.
abstract: The effects of stimulation with either 10 mumol/l norepinephrine or 85 mmol/l extracellular potassium concentration on calcium uptake were studied in muscle strips from human renal calyces and from the renal pelvis. The apparent uptake of calcium under control conditions was essentially complete after 30 min. Stimulation of the muscle strips with norepinephrine or high external potassium significantly (P less than 0.05) increased the calcium uptake over the control values at 30 and 100 min, whereas 45Ca efflux was virtually not affected. It is concluded that the mechanical responses of the muscle strips to norepinephrine or high external potassium correspond with an increased uptake of calcium suggesting that both types of activation are mediated by an increase of intracellular calcium concentration similar to that described in other smooth muscles.
authors.affiliation: Department of Urology, University of Bochum, Federal Republic of Germany.
authors.forename: L
authors.initials: L
authors.lastname: Hertle
authors.forename: H
authors.initials: H
authors.lastname: Nawrath
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007670:Kidney Calices / Q000187:drug effects / Q000378:metabolism*; D007682:Kidney Pelvis / Q000378:metabolism*; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D015220:Calcium Channels; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine