Effects of alpha-2 adrenoreceptor blockade by yohimbine on the hormonal response to hypoglycaemic stress in normal man.
In order to evaluate the effect of alpha-2 adrenoreceptor blockade on the ACTH response to insulin-induced hypoglycaemia, six normal men were studied with and without yohimbine (30 mg p.o.) premedication. Despite a similar hypoglycaemic stimulus and significant suppression of the growth hormone response (P less than 0.05), no change was observed in basal or stimulated plasma ACTH, cortisol, arginine vasopressin (AVP) or prolactin responses following yohimbine. We conclude that alpha-2 adrenoceptor blockade with yohimbine does not significantly affect the ACTH response to hypoglycaemia in man.
Cuneo
R C
RC
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
Livesey
J H
JH
Nicholls
M G
MG
Espiner
E A
EA
Donald
R A
RA
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D001127:Arginine Vasopressin / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism*; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D015016:Yohimbine / Q000494:pharmacology*
D011942:Receptors, Adrenergic, alpha; D001127:Arginine Vasopressin; D015016:Yohimbine; D000324:Adrenocorticotropic Hormone