[Autospecific antileukemia cytotoxic lymphocytes induced by interleukin-2 and their use for elimination of leukemic cells from human bone marrow in vitro].
The possibility of production of cytotoxic antileukemic lymphocytes (CTL) was studied in a mixed culture of lymphocytes and autologous leukemic cells of patients with varying types of acute leukemia. It has been shown that CTL can be induced only in the presence of exogenous preparations of lymphocytic interleukin-2. CTL can be reproduced in vitro in amounts sufficient for the conduction of immunotherapy. Four-hour incubation in vitro of the bone marrow containing leukemic cells with antileukemic CTL permits the bone marrow to be completely free of leukemic cells, and to preserve hemopoietic precursor cells (CFE-GM).
Mitskevich
P B
PB
Voĭtenok
N N
NN
D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D007959:Lymphocyte Culture Test, Mixed; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology
D007376:Interleukin-2
Poluchenie s pomoshch'iu interleĭkina-2 utospetsifichnykh protivoleĭkoznykh tsitotksicheskikkh limfotsitov i ikh ispol'zovanie dlia udaleniia leĭkoznykh kletok iz kostnogo