Effect of neonatal androgenization on the testosterone feedback sensitivity in adult rats in two lighting conditions.
Neonatally androgenized and intact adult male Wistar rats received daily, during 1 week, either testosterone propionate or sesame oil injections in periodic or constant light. Serum and pituitary gonadotropins and hypothalamic LHRH were measured. In periodic light, neonatal androgenization did not change the serum concentration or pituitary contents of gonadotropins, or the hypothalamic content of LHRH. Testosterone injections decreased serum concentration and pituitary content of gonadotropin of intact rats but failed to decrease the pituitary gonadotropin content of neonatally androgenized rats. In constant light, serum FSH was decreased in neonatally androgenized rats. Testosterone injections decreased both serum LH and FSH concentrations of intact rats but only serum LH of androgenized rats. Pituitary gonadotropin and hypothalamic LHRH contents remained unchanged. We conclude that neonatal androgenization renders the male rat hypothalamo-pituitary axis more resistant to changes of testosterone concentration in adulthood. Constant light did not sensitize the neonatally androgenized rats to testosterone, but on the contrary, testosterone injections were less effective in constant than in periodical light.
Porkka-Heiskanen
T
T
Institute of Physiology, University of Helsinki, Finland.
Laakso
M L
ML
Johansson
G
G
Stenberg
D
D
Peder
M
M
D000728:Androgens / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005246:Feedback; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D008029:Lighting; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood* / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone