[Clinical evaluation of fluconazole in the case of deep mycosis associated with leukemia].
The clinical efficacy of fluconazole at doses of 100-400 mg daily given intravenously in the treatment of 6 cases of deep mycosis complicated with leukemia was evaluated. Types of leukemia as underlying disease were acute lymphatic leukemia in 4 patients (included post bone marrow transplantation in 2 patients), acute myelocytic leukemia in 1 and acute myelomonocytic leukemia (AMMoL) in 1. Causative fungi were Candida in all patients. Diagnoses established were pulmonary or bronchial candidiasis in 3 patients, candiduria in 2 and suspected candidemia accompanied with stomatitis in 1. A patient with candiduria died from AMMoL thus the evaluation of efficacy was made with 5 patients. Overall clinical efficacies were judged to be good in 3 cases of pulmonary or bronchial candidiasis and in 1 case of suspected candidemia accompanied with stomatitis and excellent in 1 case of candiduria with an efficacy rate of 100%. No side effect, either subjective or objective, was reported with any patient. In clinical laboratory tests, elevations of serum transaminase and Al-P were observed in 2 patients and a rise of S-Cr. in 1, but all these abnormalities were judged to be related to the drugs for leukemia treatment.
Maruta
A
A
Department of Hematology and Chemotherapy, Kanagawa Cancer Center.
Matsuzaki
M
M
Fukawa
H
H
Kodama
F
F
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D015725:Fluconazole; D006801:Humans; D007275:Injections, Intravenous; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; D015725:Fluconazole