title: The mononuclear phagocyte colony-stimulating factor (CSF-1, M-CSF).
abstract: The macrophage colony-stimulating factor-1 (CSF-1, M-CSF) induces the proliferation and supports the survival of mononuclear phagocytes and mediates its pleiotropic actions by binding to cell surface receptors encoded by the c-fms proto-oncogene. The structure, biologic activities, and therapeutic potential of CSF-1 and the role of its receptor in signal transduction in normal and transformed cells are discussed.
authors.affiliation: Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors.forename: C W
authors.initials: CW
authors.lastname: Rettenmier
authors.forename: C J
authors.initials: CJ
authors.lastname: Sherr
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D005796:Genes; D006801:Humans; D007239:Infections / Q000188:drug therapy; D016173:Macrophage Colony-Stimulating Factor; D051379:Mice; D009928:Organ Specificity; D010586:Phagocytes / Q000187:drug effects*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016186:Receptor, Macrophage Colony-Stimulating Factor; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D003115:Colony-Stimulating Factors; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011994:Recombinant Proteins; D016173:Macrophage Colony-Stimulating Factor; D011505:Protein-Tyrosine Kinases; D016186:Receptor, Macrophage Colony-Stimulating Factor