Plasma androstanediol glucuronide levels during pregnancy.
In distinction to Braunstein and Horton (1985) who reported an increase in maternal 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (ADG) plasma levels during pregnancy, we observed a decrease of these levels from the 10th week of pregnancy; the decrease parallels the decrease in dehydroepiandrosterone sulphate (DHEA-S) concentration. As the latter is a major precursor of ADG, the decrease in ADG levels during pregnancy is not unexpected and in line with the concept that ADG is a parameter of androgenicity.
van Droogenbroeck
J
J
Department of Endocrinology, University Hospital, Gent, Belgium.
Vermeulen
A
A
D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000097:blood*; D000732:Androstanols / Q000097:blood*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*
D000732:Androstanols; D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate