[Presynaptic action of tubocurarine during frequent stimulation of a motor nerve].
The dependence of the end-plate potentials inhibition upon the prevention of the muscle twitches either by tubocurarine, or alpha-neurotoxin, or cutting of the fibers was studied during nerve tetanization in the frog isolated cutaneous pectoral muscles. The decrease in end-plate potentials in the course of tetanization was the strongest under the effect of tubocurarine. The latter seems to inhibit the quantum release of acetylcholine during the nerve tetanization.
Grigor'ev
V M
VM
Danilov
A F
AF
Skliarov
A I
AI
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011895:Rana ridibunda; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology*
D011950:Receptors, Cholinergic; D000109:Acetylcholine; D014403:Tubocurarine
Presinapticheskoe deĭstvie tubokurarina pri chastoĭ stimuliatsii dvigatel'nogo nerva.