title: [Bone marrow autograft treated with mafosfamide in the acceleration phase in chronic myeloid leukemia. Inversion of the clinical development].
abstract: A 21-year old male patient with Philadelphia chromosome-positive chronic myeloid leukaemia received an autologous bone marrow transplant in consolidation of the 2nd chronic phase. The bone marrow had been treated with mafosfamide in adequate doses. The post-transplantation course of the disease was marked by an inversion: the duration of the 2nd chronic phase was more than 4 times longer than that of the first one, suggesting some degree of effectiveness of autologous bone marrow transplantation performed in the 2nd chronic phase and/for of the in vitro treatment of the bone marrow with mafosfamide. Cytogenetic monitoring was pursued throughout the course of leukaemia: regression of the Philadelphia chromosome was only partial and transient, and 3 clones appeared, each of them involving chromosome 1, for which mafosfamide was most probably responsible.
authors.affiliation: Service des Maladies du sang, Centre hospitalier universitaire Saint-Antoine, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Fouillard
authors.forename: J
authors.initials: J
authors.lastname: Van Den Akker
authors.forename: J P
authors.initials: JP
authors.lastname: Laporte
authors.forename: A
authors.initials: A
authors.lastname: Najman
authors.forename: C
authors.initials: C
authors.lastname: Perot
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: L
authors.initials: L
authors.lastname: Douay
authors.forename: F
authors.initials: F
authors.lastname: Isnard
authors.forename: J L
authors.initials: JL
authors.lastname: Taillemite
authors.forename: N C
authors.initials: NC
authors.lastname: Gorin
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000601:surgery*; D008297:Male; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents; C048341:mafosfamide; D003520:Cyclophosphamide
vernacular_title: Autogreffe de moelle osseuse traitée par mafosfamide en phase d'accélération de leucémie myéloïde chronique. Inversion de l'évolution clinique.