Effects of serum amyloid A protein on lymphocytes, HeLa, and MRC5 cells in culture.
A major human acute phase protein, the serum amyloid A protein, has been tested in vitro for its effect on lymphocyte proliferation, the formation of E-stable rosettes, as well as the growth of HeLa and MRC5 cell cultures. Serum amyloid A protein has been found to be markedly inhibitory at 30, 100, 200, and 300 micrograms/mL, and is a very potent inhibitor of in vitro biological functions.
Peristeris
P
P
Pasteur Lyon Novotec, Domaine du Poirier, l'Arbresle, France.
Gaspar
A
A
Gros
P
P
Laurent
P
P
Bernon
H
H
Bienvenu
J
J
D000210:Acute-Phase Reaction / Q000097:blood*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000502:physiology; D012397:Rosette Formation; D000685:Serum Amyloid A Protein / Q000502:physiology*
D000685:Serum Amyloid A Protein