Bilateral acute heart atrial auriectomy reduced diuresis and natriuresis following hypertonic sodium load in anaesthetized dogs.
Anaesthetized dogs were deprived of a portion of the atrial natriuretic factor producing tissue by bilateral acute heart atrial auriectomy. Their ability to respond by diuresis and natriuresis either to the expansion of extracellular fluid volume with isotonic saline (3% b.w.) or to hyperosmolality induced by hypertonic saline loading (0.13% b.w. of 20% NaCl solution) was subsequently reduced by about 50%. It is thus suggested that atrial natriuretic system may also play a role in osmoregulation by taking part in the promotion of renal sodium excretion.
Okolicány
J
J
Institute of Experimental Surgery, Slovak Academy of Sciences, Bratislava.
Lichardus
B
B
Gabauer
I
I
Ponec
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001794:Blood Pressure; D002496:Central Venous Pressure; D004231:Diuresis; D004285:Dogs; D005110:Extracellular Space; D005260:Female; D005919:Glomerular Filtration Rate; D006325:Heart Atria / Q000601:surgery; D007552:Isotonic Solutions; D007700:Kinetics; D008297:Male; D009318:Natriuresis; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000652:urine; D014882:Water-Electrolyte Balance
D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D009320:Atrial Natriuretic Factor; D012964:Sodium