title: Responses of immunoglobulin-secreting cells in the skin of pigs during Sarcoptes scabiei infestation.
abstract: Investigations using immunofluorescence and immunoperoxidase techniques revealed a gradual, but marked, increase in the numbers of immunoglobulin-secreting cells in the skin of pigs during the development of lesions of sarcoptic mange. This was followed by a marked decrease as the lesions regressed. The rise and fall in numbers of these immunoglobulin-secreting cells were observed in both newborn and older animals as they developed signs of cutaneous disease. IgG-secreting cells were the major immunoglobulin-containing cells, followed by IgM- and then IgA-containing cells in the skin of newborn animals. In older pigs, IgM-secreting cells were most prevalent, followed by IgG- and IgA-secreting cells. In multiple infestations, immunoglobulin-secreting cells in the dermis showed very little increase in numbers following the second infestation. Third, fourth and fifth infestations produced little or no increase.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
authors.forename: G H
authors.initials: GH
authors.lastname: Morsy
authors.forename: S M
authors.initials: SM
authors.lastname: Gaafar
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000921:Antibody-Producing Cells / Q000276:immunology* / Q000473:pathology; D002455:Cell Division; D005260:Female; D005455:Fluorescent Antibody Technique; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008297:Male; D012532:Scabies / Q000276:immunology / Q000662:veterinary*; D012867:Skin / Q000276:immunology* / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins