Pharmacological properties of YM-11124, a selective immunosuppressive agent for cell-mediated immunity.
Effect of YM-11124 on cell-mediated immune responses, type I to type III allergic reactions and inflammatory reaction was determined in mice, rats and guinea pigs. YM-11124 inhibited picryl chloride- and methylated bovine serum albumin-induced delayed-type hypersensitivity reactions by the treatment during both the sensitization and the elicitation phases in mice. Bilateral adrenalectomy did not prevent the suppression of DTH response by YM-11124. YM-11124 significantly prolonged the survival time of allogenic skin grafts in mice. Furthermore, YM-11124 inhibited the passive Arthus reaction in guinea pigs and the reversed passive Arthus reaction in rats. However, YM-11124 did not affect the passive cutaneous anaphylaxis reaction in rats, Forssman shock in guinea pigs and paw edema in rats. These results indicate that YM-11124 suppresses not only cell-mediated immune responses (type IV allergic reactions) but also type III allergic reactions without influence on types I and II allergic reactions as well as acute inflammation.
Tomioka
K
K
Department of Pharmacology, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Yamada
T
T
Mase
T
T
Murase
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001183:Arthus Reaction / Q000276:immunology; D052160:Benzothiazoles; D002351:Carrageenan / Q000037:antagonists & inhibitors; D005577:Forssman Antigen / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010853:Picryl Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology; D016038:Skin Transplantation; D013844:Thiazoles / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052160:Benzothiazoles; D007166:Immunosuppressive Agents; D013844:Thiazoles; D012710:Serum Albumin, Bovine; C061967:YM 11124; D002351:Carrageenan; D005577:Forssman Antigen; D010853:Picryl Chloride