title: [Plasminogen activators as thrombolytic agents in myocardial infarction].
abstract: Administration of thrombolytic agents can determine recanalization of thrombosed coronary arteries. Apparently, the earlier reperfusion is performed the better the prognosis of myocardial infarction. Streptokinase was administered to 117 patients with myocardial infarction at the "Instituto do Coração da Universidade de São Paulo" and angiographic patency of the vessel was restored in as many as 87% of them. New thrombolytic agents, such as tissue plasminogen activator (tPA), single chain urokinase-type Plasminogen Activator (scuPA) and Anisoylated Plasminogen Streptokinase Activator Complex (APSAC) have been evaluated in clinical trials. Recent advances in thrombolytic therapy and comparative aspects of the various agents currently available are reviewed.
authors.forename: D A
authors.initials: DA
authors.lastname: Chamone
authors.forename: C
authors.initials: C
authors.lastname: Massumoto
authors.forename: A Y
authors.initials: AY
authors.lastname: Fujimura
authors.forename: F
authors.initials: F
authors.lastname: Pileggi
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
mesh_terms: D000595:Amino Acid Sequence; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D009203:Myocardial Infarction / Q000628:therapy*; D010960:Plasminogen Activators / Q000737:chemistry / Q000627:therapeutic use*; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Ativadores do plasminogênio como agentes trombolíticos no infarto do miocárdio.