Cough induced by enalapril but not by captopril.
We report a 68 yr old woman with hypertension who developed a dry cough on enalapril but not on captopril therapy. Pulmonary function tests, methacholine inhalation challenges, total blood eosinophil counts, and changes in plasma concentrations of prostaglandin E2 and thromboxane B2 did not explain the difference in the adverse reaction between these two angiotensin converting enzyme inhibitors.
Puolijoki
H
H
Tampere University Central Hospital, Finland.
Nieminen
M
M
Moilanen
E
E
Siitonen
L
L
Lahdensuo
A
A
Reinikainen
P
P
Vapaatalo
H
H
D000368:Aged; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced*; D004656:Enalapril / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012129:Respiratory Function Tests
D004656:Enalapril; D002216:Captopril