title: Incidence and effects of herpes simplex virus infection after autologous bone marrow transplantation for solid tumours.
abstract: In a prospective study of 44 patients, who underwent autologous bone marrow transplantation (ABMT) for solid tumours, the results of serial viral cultures and determination of complement-fixing antibodies to herpes simplex virus (HSV) were analysed. No primary infections with HSV occurred. Of 31 initially HSV-seropositive ABMT patients, 61% developed positive HSV cultures. Half of these patients showed a significant antibody rise. Active HSV infection did not influence the recovery of the bone marrow after ABMT, but coincided with a significantly increased number of febrile days.
authors.forename: P O
authors.initials: PO
authors.lastname: Mulder
authors.forename: P
authors.initials: P
authors.lastname: Schröder
authors.forename: H G
authors.initials: HG
authors.lastname: de Vries-Hospers
authors.forename: S
authors.initials: S
authors.lastname: van der Geest
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
authors.forename: N H
authors.initials: NH
authors.lastname: Mulder
authors.forename: E G
authors.initials: EG
authors.lastname: de Vries
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D011446:Prospective Studies; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification; D014182:Transplantation, Autologous