[Effect of a natriuretic factor of hepatic origin on the indices of water-salt metabolism and blood circulation].
The influence of natriuretic factor inhibiting the Na--K--ATPase, on the volume-regulating function of kidneys and the hemodynamics was studied in dogs. A single administration of natriuretic factor in a dose increasing the renal excretion of water, sodium and osmotically active substances, affected the hemodynamics. The changes of both the central hemodynamics and of the renal blood circulation were of a shorter duration compared with the changes in renal functions. The activation of water and electrolyte-excreting activity of the kidneys seems to be due to a reduced tubular reabsorption but not to the glomerular filtration.
Konovchuk
V N
VN
Ivanov
Iu I
IuI
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008099:Liver / Q000502:physiology*; D008297:Male; D045283:Natriuretic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D045283:Natriuretic Agents; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie natriureticheskogo faktora pechenochnogo proiskhozhdeniia na pokazateli vodno-solevogo obmena i krovoobrashcheniia.