title: Selenium supplementation does not alter platelet activation in subjects with normal selenium status.
abstract: The effect of Se supplementation on the plasma concentrations of platelet specific proteins, beta-thromboglobulin (beta TG) and platelet factor 4 (PF4), was determined in twenty young women with normal selenium (Se) status using a double blind protocol. Selenium supplementation for 4 weeks (150 micrograms/day), did not elevate the initial mean plasma Se level 95 +/- 4 ng/ml above this level, nor did it alter the plasma beta TG/PF4. Moreover, all the other parameters of the body antioxidative status (plasma alpha-tocopherol, retinol and uric acid and whole blood glutathione) measured in this experiment stayed unaltered during the 4-week supplementation period. The results indicate no relationship between Se supplementation and platelet function in subjects with normal Se status.
authors.affiliation: Department of Nutrition, University of Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Mutanen
authors.forename: L
authors.initials: L
authors.lastname: Viita
authors.forename: H M
authors.initials: HM
authors.lastname: Mykkänen
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D009752:Nutritional Status; D015539:Platelet Activation / Q000187:drug effects*; D010978:Platelet Factor 4 / Q000378:metabolism*; D012643:Selenium / Q000097:blood / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism*
chemical_list: D001620:beta-Thromboglobulin; D014801:Vitamin A; D014810:Vitamin E; D014527:Uric Acid; D010978:Platelet Factor 4; D005978:Glutathione; D012643:Selenium