Modelling vitamin B6 metabolism in rodents (review).
Several improvements have been incorporated into a previously described compartmental model of vitamin B6 metabolism in order to expand the application of the model to non-steady state conditions such as growing animals and differing vitamin B6 intakes. A function which describes the growth of rats receiving various vitamin B6 intakes has been developed. The turnover rates for enzymatic reactions have been written in a form which responds to changes in substrate concentration. The predictions of the model are in reasonable agreement with several sets of data from the literature. Further refinement of the model is in progress.
Coburn
S P
SP
Department of Biochemistry, Fort Wayne State Developmental Center, IN 46835.
Townsend
D W
DW
D000818:Animals; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism*; D051381:Rats
D011736:Pyridoxine