ATP-synthase complex: the mechanism of control of ion fluxes induced by cumene hydroperoxide in mitochondria.
In state 4, the cumene hydroperoxide-induced decrease of mitochondrial transmembrane potential is prevented by the free radical scavenger, butylhydroxytoluene. This decrease is accompanied by accumulation of lipid hydroperoxides. Oligomycin suppresses the cumene hydroperoxide-induced uncoupling of mitochondria, but has no significant effect on lipid peroxidation. The transition of mitochondria from state 4 to state 3 by ADP addition leads to the suppression of both lipid peroxidation and mitochondrial uncoupling. This effect on lipid peroxidation is prevented by carboxyatractyloside and oligomycin.
Novgorodov
S A
SA
A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR.
Gudz
T I
TI
Mohr YuE
Goncharenko
E N
EN
Yaguzhinsky
L S
LS
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004024:Dicyclohexylcarbodiimide / Q000494:pharmacology; D004563:Electrochemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009840:Oligomycins / Q000494:pharmacology; D009861:Onium Compounds / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D051381:Rats
D001555:Benzene Derivatives; D009840:Oligomycins; D009861:Onium Compounds; D009943:Organophosphorus Compounds; D002084:Butylated Hydroxytoluene; D004024:Dicyclohexylcarbodiimide; D000244:Adenosine Diphosphate; D006180:Proton-Translocating ATPases; C007164:cumene hydroperoxide; C013289:tetraphenylphosphonium