Beta-2 microglobulin amyloidosis in a patient on long-term continuous ambulatory peritoneal dialysis (CAPD).
A 61-year-old female patient with ESRD due to analgesic nephropathy and treated solely with CAPD for 81 months is described. During this period she developed peritonitis 4 times. She eventually died of acute pulmonary edema due to coronary heart disease. The autopsy showed an analgesic nephropathy with contracted kidneys, diffuse peritoneal fibrosis, and articular and periarticular amyloidosis of AB2m-type. This form of amyloidosis is well known after hemodialysis; it was, however, not observed heretofore after sole long-term CAPD.
Colombi
A
A
Renal Unit, Med. Dep. Kantonsspital, Lucerne, Switzerland.
Wegmann
W
W
D000009:Abdominal Muscles / Q000473:pathology; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000628:therapy*; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010537:Peritoneum / Q000473:pathology; D010615:Phenacetin / Q000009:adverse effects; D013583:Synovial Membrane / Q000473:pathology; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001613:beta 2-Microglobulin; D010615:Phenacetin