DNA hybridization studies of a nucleotide sequence homologous to transposon Tn1545 in the "Minnesota" strain of multiresistant Streptococcus pneumoniae isolated in 1977.
Nucleotide sequences homologous to the transposon-specific region and the tetM determinant mediating tetracycline resistance of the multiresistance transposon Tn1545, originating in Streptococcus pneumoniae, were detected by hybridization in the first multiresistant pneumococcus reported in the United States. The sequences were localized to a common 25-kb EcoRI restriction fragment of the chromosome.
Cooksey
R C
RC
Antimicrobics Investigations Branch, Centers for Disease Control, Atlanta, Georgia 30333.
Swenson
J M
JM
Clark
N C
NC
Thornsberry
C
C
D001345:Autoradiography; D002675:Child, Preschool; D015342:DNA Probes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics*; D015246:Deoxyribonuclease EcoRI; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics*
D015342:DNA Probes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D015246:Deoxyribonuclease EcoRI