CORGEN: a FORTRAN-77 generator of standard and non-standard DNA helices from the sequence.
An analytical procedure CORGEN generates a variety of DNA double-stranded structures from user-supplied sequence using a nucleic acid database incorporated into a standard FORTRAN-77 program. Alternatively, the cylindrical polar coordinates of DNA components may be supplied from the external table. An algorithm that performs intercalation sites in DNA is described. This procedure can be used to generate complexes of antibiotics with DNA. Non-standard DNA structures can be built by alternating the global helical twist and global helical rise in the regular DNA helix. The procedures described can be used for computer generation of a variety of non-standard DNA structures which can be subjected to molecular mechanics and dynamics simulations.
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Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA; D007364:Intercalating Agents; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides; D012984:Software; D009353:Zinostatin
D007364:Intercalating Agents; D011089:Polydeoxyribonucleotides; D004247:DNA; D009353:Zinostatin