[Use of immunosuppressed mice in an attempt to improve the diagnosis of infection by Trypanosoma cruzi].
In order to demonstrate low level parasitemias of Trypanosoma cruzi, a procedure based on the pharmacologic development of immunosuppression and subsequente innoculation of a test blood specimen was evaluated in mice. Prednisone was effective for the procedure and my be considered for diagnosis and for clinical and laboratorial follow-up of patients with Chagas'disease, submitted to heart transplantation. However, prednisone effectiveness depended from the level of parasitemia.
Miyamoto
A
A
Campos
R
R
Amato Neto
V
V
de Souza
H B
HB
Matsubara
L
L
Moreira
A A
AA
D000818:Animals; D014355:Chagas Disease / Q000276:immunology / Q000401:mortality / Q000469:parasitology*; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D011241:Prednisone / Q000494:pharmacology*
D011241:Prednisone
Utilização de camundongos imunodeprimidos como tentativa de aprimoramento do diagnóstico da infecção pelo Trypanosoma cruzi.