[Relationship between central recurrence and time-dose factors in patients with carcinoma of uterine cervix after radiotherapy].
Time-dose factor (TDF) value at point A was evaluated in 75 patients with central recurrence and 100 patients free of cancer for more than 5 years after radiotherapy serving as control. The results showed that the mean TDF at point A was 131 +/- 16 and, 139 +/- 15 in patients with Stage II lesions in central recurrence and control groups and 134 +/- 18 and 144 + 14 in patients with Stage III lesions in both groups, respectively. The TDF was all lower in the recurrence groups than those in the control groups. There was significant difference between the two groups (P less than 0.02 and P less than 0.01). The results also showed that the TDF at point A was significantly different between the recurrent and control groups (P less than 0.05) when it was more than 135 and 140 in Stage II and III lesions. It is pointed out that, even with same dose delivered to point A, the lower TDF value at point A is possibly the reason of central failure in cervical cancer treatment. The authors suggest that total TDF value at point A in Stage II and III lesions be no less than 135 and 140.
Gao
J Z
JZ
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
D001918:Brachytherapy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*