Correlation between plasma levels of growth factors and von Willebrand factor.
Intimal proliferation of smooth muscle cells is an important characteristic of developing atherosclerotic lesions and late occlusion of venous bypass grafts. Platelet-derived growth factor, released from aggregating platelets at sites of endothelial injury, has been suggested as a main factor responsible for intimal hyperplasia. The von Willebrand factor is a platelet binding protein secreted by endothelial cells and increased plasma levels of this factor has been identified as a marker of endothelial injury. In the present study we have analysed plasma levels of von Willebrand factor and growth factors in healthy controls, young post-infarction patients and patients with recent coronary bypass surgery. The results demonstrate a significant correlation between plasma growth factor activity and the level of von Willebrand factor (R = 0.52, p less than 0.01) and support the notion of a coupling between endothelial injury and release of platelets mitogens.
Nilsson
J
J
Department of Medicine, Karolinska Instituet, Karolinska Hospital, Stockholm, Sweden.
Elgue
G
G
Wallin
M
M
Hamsten
A
A
Blombck
M
M
D000328:Adult; D000368:Aged; D000818:Animals; D002478:Cells, Cultured; D003327:Coronary Disease / Q000503:physiopathology; D004247:DNA / Q000096:biosynthesis; D006023:Glycoproteins / Q000097:blood; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D015849:Plasminogen Inactivators; D051381:Rats; D011919:Rats, Inbred Strains; D001620:beta-Thromboglobulin / Q000097:blood; D014842:von Willebrand Diseases / Q000503:physiopathology; D014841:von Willebrand Factor / Q000032:analysis*
D006023:Glycoproteins; D006133:Growth Substances; D015849:Plasminogen Inactivators; D001620:beta-Thromboglobulin; D014841:von Willebrand Factor; D004247:DNA