Antagonism by pindolol, but not betaxolol, of 8-OH-DPAT-induced facilitation of male rat sexual behavior.
8-OH-DPAT (0.25 mg/kg s.c.) produced a facilitation of the male rat sexual behavior, characterized by a decrease in the number of intromissions preceding ejaculation and in the time to ejaculation. This facilitation of the sexual behavior was antagonized by administration of the 5-HT and beta-adrenoceptor antagonist pindolol (4 mg/kg i.p.), but not by the selective beta-adrenoceptor antagonist betaxolol (4 mg/kg i.p.). Neither pindolol (2-8 mg/kg), nor betaxolol (2-8 mg/kg), produced any statistically significant effects per se on the male rat sexual behavior, as observed here (mounts, intromissions, ejaculation latency or the post-ejaculatory interval). A higher dose (16 mg/kg) of betaxolol produced a statistically significant reduction in the number of intromissions preceding ejaculation and in the ejaculation latency. The antagonism by pindolol of 8-OH-DPAT-induced effects on male rat sexual behavior suggests an involvement of 5-HT1A receptors in the facilitation of this behavior produced by 8-OH-DPAT.
Ahlenius
S
S
Department of Neuropharmacology, Astra Research Centre, Södertälje, Sweden.
Larsson
K
K
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D015784:Betaxolol; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D008297:Male; D009281:Naphthalenes / Q000037:antagonists & inhibitors*; D010869:Pindolol / Q000494:pharmacology*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D009281:Naphthalenes; D011412:Propanolamines; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D010869:Pindolol; D015784:Betaxolol