The effect of yohimbine on plasma levels of T3, T4 and cortisol in xylazine-immobilized white-tailed deer.
1. The effect of yohimbine (Y) on blood levels of thyroxine (T4), triiodothyronine (T3), and cortisol was investigated in 5 mature male white-tailed deer immobilized with xylazine hydrochloride (X). 2. T4 levels were erratic in X-treated deer, but stabilized in the X- and Y-treated deer. 3. T3 remained unchanged in both groups. 4. Cortisol levels have increased in X-treated deer, but declined in X- and Y-treated deer. 5. Yohimbine is a potent and safe antidote of X not affecting T3 and T4. Caution should be used in using R or Y in cortisol studies.
Bubenik
G A
GA
Department of Zoology, University of Guelph, Ontario, Canada.
Brown
R D
RD
D000818:Animals; D003670:Deer / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D013843:Thiazines / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D014991:Xylazine / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
D013843:Thiazines; D014284:Triiodothyronine; D014991:Xylazine; D015016:Yohimbine; D013974:Thyroxine; D006854:Hydrocortisone