title: Conservative management of an echovirus 11 outbreak in a neonatal unit.
abstract: Two babies in a neonatal unit presented on the same day with meningitis due to echovirus 11, which was thought to have been introduced by staff. At this time echovirus 11 was also isolated from the stools of eight other babies; five of them did not have signs of infection. No intervention was made except to emphasise the importance of handwashing. There was evidence of secondary spread to two babies who were both clinically well. The attack rate was twelve (29%) of forty-one babies exposed. Seven of the twelve infected babies were born before 30 weeks' gestation and would have had little or no maternal antibody, yet only two of the seven babies had signs of infection. Despite lack of special measures, all babies recovered. Most cases of horizontally acquired neonatal echovirus infection are mild: extreme measures in the management of outbreaks are unnecessary.
authors.affiliation: Department of Paediatrics, John Radcliffe Hospital, Oxford.
authors.forename: D
authors.initials: D
authors.lastname: Isaacs
authors.forename: S R
authors.initials: SR
authors.lastname: Dobson
authors.forename: A R
authors.initials: AR
authors.lastname: Wilkinson
authors.forename: P L
authors.initials: PL
authors.lastname: Hope
authors.forename: R
authors.initials: R
authors.lastname: Eglin
authors.forename: E R
authors.initials: ER
authors.lastname: Moxon
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D004739:England; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005069:Evaluation Studies as Topic; D005260:Female; D006235:Hand Disinfection; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D007363:Intensive Care Units, Neonatal; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents