title: [Case report of catecholamine-secreting carotid body tumor].
abstract: We encountered a case of catecholamine-secreting carotid body tumor which has never been reported in Japan. The patient was a 20-year old man, who complained of a mass located at the right neck and hypertensive symptoms such as loss of consciousness at extension of the neck, fatigability, etc. Carotid angiography and computed tomography (CT scan) revealed a carotid body tumor. Before operation, a mild hypertension was noted, serum and urinary levels of norepinephrine showed abnormal increase, and phentolamine test was positive. After the tumor was dissected by a surgical procedure associated with carotid reconstruction, blood pressure and norepinephrine levels clearly trended to decrease and phentolamine test returned to negative. Histopathologically, the tumor was a paraganglioma with so-called "organoid" pattern. The tumor was not chromaffin, but the presence of neurosecretory granules was confirmed under electron microscope. In one-year follow up after the operation, no sign suggestive of "latent" or newly arising paraganglioma was noted in assay of catecholamines in serum and urine, nor on adrenal CT scan.
authors.forename: M
authors.initials: M
authors.lastname: Nakamizo
authors.forename: S
authors.initials: S
authors.lastname: Kamata
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Yokota
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Aramaki
mesh_terms: D000328:Adult; D002345:Carotid Body Tumor / Q000378:metabolism* / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism*; D006801:Humans; D008297:Male; D010236:Paraganglioma, Extra-Adrenal / Q000378:metabolism* / Q000473:pathology
chemical_list: D002395:Catecholamines