[The effect of 3',5'-cyclic adenylic acid (cAMP) on the growth of bacteria].
The effect of intracellular cAMP level on the growth of bacteria was studied with E. coli AS 1.797, Corynebacterium pekinense AS 1.299 and Bacillus megaterium AS 1.217. The experimental results show that the growth of E. coli AS 1.797 was decreased with increasing cAMP level in cell. With glucose as the sole carbon source, intracellular cAMP is low, and growth of E. coli AS 1.797 was inhibited by exogenous cAMP, but the analog metabolite of cAMP-5'-AMP had no effect on growth. When E. coli AS 1.797 was grown in media containing lactose, maltose and glycerin respectively, intracellular cAMP level is high, and exogenous cAMP did not inhibited the cell growth. When Corynebacterium pekinense AS 1.299 took glucose as carbon source the growth of this bacterium was also inhibited by exogenous cAMP, but the inhibition of cAMP was not specific, its role can be exchanged by 5'-AMP. B. megaterium AS 1.217 cultivated in different carbon source (include glucose) do not contain cAMP in cell, and its growth was not inhibited by exogenous cAMP. 5'-AMP had also no effect on the growth of this bacterium. Thus, the conclusion seems that the cAMP is not essential for the growth of bacteria, and it is a regulator that act a negative regulation in cell growth, but this regulator is of no effect for the growth of B. megaterium AS 1.217.
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D001410:Bacillus megaterium / Q000187:drug effects / Q000254:growth & development*; D003352:Corynebacterium / Q000187:drug effects / Q000254:growth & development*; D000242:Cyclic AMP / Q000032:analysis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*
D000242:Cyclic AMP