title: [Recovery kinetics of hematopoiesis after peripheral blood stem cell autotransplantation].
abstract: Hematopoietic recovery kinetics was evaluated in five children with therapy-refractory cancers who received peripheral blood stem cell autotransplantation (PBSCT) following marrow-ablative chemotherapy. Four children received graft containing more than 1.5 X 10(4) CFU-GM/kg and days required to achieve granulocyte counts of greater than 0.5 X 10(9)/l were 6, 10, 13, and 18, respectively. One patient received 0.9 X 10(4) CFU-GM/kg, but, recovery of granulopoiesis was retarded (greater than 30 days). The days required to achieve platelet count of greater than 50 X 10(9)/l were 12, 15, 16, 195, and greater than 240, respectively. Transient decrease of blood cell counts developed 3 to 5 weeks after transplantation and thereafter, the recovery of hematopoiesis became stable. With the use of a large number of progenitors, PBSCT seems to be safe and effective new type of stem cell rescue operation as an alternative to bone marrow transplantation.
authors.affiliation: Dept. of Pediatrics, University of Tokushima.
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Suzue
authors.forename: J
authors.initials: J
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Kamata
authors.forename: M A
authors.initials: MA
authors.lastname: Huq
authors.forename: T
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006098:Granulocytes; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D010976:Platelet Count; D013601:T-Lymphocytes; D014182:Transplantation, Autologous