title: [Antibiotic resistance plasmids from Serratia marcescens and their elimination by DNA-gyrase inhibitors].
abstract: We studied the effects of ciprofloxacin on 73 strains of Serratia marcescens. In the first place, we have tested their plasmidic content: 76% of Serratia marcescens strains contained plasmids by electrophoresis, and 29% of these plasmids were self-transmissible by conjugation. Secondly, we studied the plasmid stability with regard to ciprofloxacin. We obtained a spontaneous cure with 19% of plasmids, and ciprofloxacin, at very low concentrations (0.4 mg/l), increased the rate of cure and more efficiently than novobiocin, a compound used as a known curing agent.
authors.affiliation: CNRS URA 531, Faculté de Médecine, Université de Franche-Comté, Besançon.
authors.forename: C
authors.initials: C
authors.lastname: Llanes
authors.forename: Y
authors.initials: Y
authors.lastname: Michel-Briand
authors.forename: M
authors.initials: M
authors.lastname: Couturier
authors.forename: M
authors.initials: M
authors.lastname: Thouverez
authors.forename: C
authors.initials: C
authors.lastname: Bailly
mesh_terms: D015373:Bacterial Typing Techniques; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D010957:Plasmids / Q000187:drug effects*; D012703:Serotyping; D012706:Serratia marcescens / Q000145:classification / Q000235:genetics*; D059005:Topoisomerase II Inhibitors
chemical_list: D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin
vernacular_title: Les plasmides de résistance aux antibiotiques de Serratia marcescens et leur élimination par les inhibiteurs de l'ADN-gyrase.