Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-D-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.
Thibault
O
O
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Joly
M
M
Muller
D
D
Schottler
F
F
Dudek
S
S
Lynch
G
G
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D004558:Electric Stimulation; D005998:Glycine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D016202:N-Methylaspartate; D051381:Rats; D011919:Rats, Inbred Strains; D013096:Spermine / Q000494:pharmacology; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D013096:Spermine; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D005998:Glycine