Pathogenic effect of osteopetrosis virus strain MAV-2(0) on guinea fowl pancreas.
Osteopetrosis virus strain MAV-2(0) in guinea fowl pancreas induces early unspecific changes in separate acini and the development of neoplasia among apparently unaffected acinar tissue. The tumors were classified as serous and mucinous adenomas and adenocarcinomas, as well as poorly differentiated carcinomas. Foci of phenotypically altered acinar cells were observed in single experimental birds.
Kirev
T T
TT
Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia.
Toshkov
I A
IA
Mladenov
Z M
ZM
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D001353:Avian Leukosis / Q000382:microbiology*; D001354:Avian Leukosis Virus / Q000472:pathogenicity*; D009189:Avian Myeloblastosis Virus / Q000472:pathogenicity*; D002471:Cell Transformation, Neoplastic; D004487:Edema; D006965:Hyperplasia; D010179:Pancreas / Q000382:microbiology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology; D011200:Poultry; D014617:Vacuoles