title: Absence of perinatal transmission of blood-borne non-A, non-B hepatitis virus by chimpanzees with acute and chronic infection.
abstract: Two chimpanzees were born to parents with chronic non-A, non-B hepatitis and remained with their mothers until 12 and 18 months, respectively. The infants were followed from 7 to 8 weeks of age with biweekly or monthly blood samples and with monthly liver biopsies from 4 to 7 months after birth. Another chimpanzee, along with both of its parents, was held throughout the parents' acute infection with non-A, non-B hepatitis; at this time the infant was 14-16 months of age, and it was followed with bi-weekly blood samples and monthly biopsies from the time of potential exposure for 20 months. No abnormalities indicative of non-A, non-B hepatitis were detected in these animals. During the 29 to 35 months of follow-up, alanine aminotransferases and gamma glutamyl-transferases (GGPT) levels remained well within normal range for animals held in the same facility. Histologic and electron microscopic examination of liver tissue revealed no abnormalities.
authors.affiliation: Vilab II, Liberian Institute for Biomedical Research, Robertsfield.
authors.forename: B
authors.initials: B
authors.lastname: Brotman
authors.forename: W
authors.initials: W
authors.lastname: Boehle
authors.forename: A M
authors.initials: AM
authors.lastname: Prince
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D001706:Biopsy; D002908:Chronic Disease; D004198:Disease Susceptibility; D005260:Female; D006526:Hepatitis C / Q000473:pathology / Q000635:transmission*; D006518:Hepatitis Viruses / Q000302:isolation & purification / Q000472:pathogenicity*; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange; D002679:Pan troglodytes; D011247:Pregnancy; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase