Association and sibpair analysis for the HLA, Gm, Km, and insulin polymorphisms in multiplex IDDM families.
A log-linear model was used to analyze three-way interactions between IDDM and pairs of genetic markers. To do this, a special sample dataset was selected by taking one affected and one unaffected child from each family. Some three-way interactions were found for associations between insulin-dependent diabetes mellitus (IDDM), HLA-DR, and DQ restriction enzyme fragment length polymorphism (RFLP) patterns. No three-way interaction was found for IDDM, HLA-DR, and Gm or Km. An extended sibpair analysis was applied to the HLA-B,DR loci and to the Gm, Km, and insulin gene polymorphisms. The well-known result for IDDM and HLA was reproduced. For Gm, Km, and the insulin gene no cosegregation with IDDM could be found.
Fimmers
R
R
Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany.
Neugebauer
M
M
Dennert
J
J
Wienker
T
T
Baur
M P
MP
D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005819:Genetic Markers; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007328:Insulin / Q000235:genetics*; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012494:Sampling Studies
D005819:Genetic Markers; D006684:HLA-DR Antigens; D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D007328:Insulin