Infantile gastroenteritis associated with excretion of pestivirus antigens.
Faeces from children under 2 years old who had gastroenteritis that could not be attributed to recognised enteric pathogens were examined with a monoclonal-antibody-based immunoassay for Pestivirus antigens. Such antigens were detected in 30 of 128 episodes of gastroenteritis. Children without diarrhoeal disease and children infected with rotaviruses had little evidence of Pestivirus infection (faeces positive in 1 of 28 and 1 of 31, respectively). The diarrhoeal disease in children excreting Pestivirus antigens resembled that in other children except that it was more commonly associated with signs and symptoms of respiratory inflammation.
Yolken
R
R
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Dubovi
E
E
Leister
F
F
Reid
R
R
Almeido-Hill
J
J
Santosham
M
M
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis*; D001130:Arizona; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D005243:Feces / Q000032:analysis; D005759:Gastroenteritis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D010576:Pestivirus / Q000276:immunology*; D011446:Prospective Studies; D014036:Togaviridae Infections / Q000150:complications* / Q000453:epidemiology
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral