Anti-acid secretion activity of drugs cimetidine, ranitidine, tiotidine D 15,144 in dogs fixed with gastric fistulae.
1. Acid secretion for each dog has reached a near maximum (100%) at the 6th samples, 90 min after the intravenous infusion of histamine (10 mu ghr-1, or approximately equal to 0.3 mghr-1). 2. 0.5 mgkg-1 Cimetidine had produced a mean inhibition of 47% on the stomach. 3. 0.1 mgkg-1 Ranitidine (D 14,951) could only inhibit a maximum of 28%, and the secretion had return to normal in just 30 min. 4. 0.025 mgkg-1 Tiotidine (D 15,104) had inhibited 53% acid secretion within 15 min of exposure. Recovery was quite similar to that of Cimetidine, at 150 min. 5. At a dosage one fifth of Cimetidine (0.1 mgkg-1) D 15,144 had depressed 35% of acid secretion at the first 15 min. The inhibition is gradually increased to about 43% (at 30 min), and was maintained for the next 105 min.
Ridzwan
B H
BH
Department of Biology, FSSA, UKM Kampus Sabah, Kota Kinabalu, Malaysia.
Waton
N G
NG
Jais
A M
AM
D000818:Animals; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005747:Gastric Fistula / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine; C023990:tiotidine