Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level.
Subjects drawn from a population-based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought.
Pedersen
J C
JC
Institute of Medical Genetics, University of Oslo, Norway.
Berg
K
K
D000367:Age Factors; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood*; D015342:DNA Probes; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics* / Q000378:metabolism; D012016:Reference Values; D012737:Sex Factors; D014427:Twins
D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D015342:DNA Probes; D011973:Receptors, LDL