title: Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain.
abstract: Characteristic neuropathological white matter changes in the brains of patients dying from the acquired immune deficiency syndrome (AIDS) suggest pathogenetic involvement of either the PrP27-30 gene or a scrapie-related prion; however, proteinase-K resistant scrapie-like proteins could not be detected in brain tissue from AIDS patients.
authors.affiliation: Department of Microbiology, Adelaide Children's Hospital, South Australia.
authors.forename: P N
authors.initials: PN
authors.lastname: Goldwater
authors.forename: J C
authors.initials: JC
authors.lastname: Paton
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D015153:Blotting, Western; D001923:Brain Chemistry; D006801:Humans; D018622:PrP 27-30 Protein; D011328:Prions; D014764:Viral Proteins / Q000032:analysis
chemical_list: D011328:Prions; D014764:Viral Proteins; D018622:PrP 27-30 Protein