[Problems of the molecular mechanism of the effects of synthetic antiviral drugs].
Results of experimental study on the effect of bonafton, tebrofen, florenal and riodoxol on synthesis of virus specific proteins and RNA are presented. Selective inhibition of RNA-transcripts and respective proteins under the effect of bonafton was revealed. Florenal had a selective inhibitory effect on synthesis of virus specific proteins. Riodoxol did not inhibit synthesis of viral RNA and proteins of the influenza virus.
Fadeeva
N I
NI
Gerasina
S F
SF
D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D005449:Fluorenes / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D007251:Influenza, Human / Q000188:drug therapy* / Q000382:microbiology; D009285:Naphthoquinones / Q000494:pharmacology / Q000627:therapeutic use; D011075:Polybrominated Biphenyls / Q000494:pharmacology / Q000627:therapeutic use; D012367:RNA, Viral / Q000037:antagonists & inhibitors / Q000187:drug effects; D012118:Resorcinols / Q000494:pharmacology / Q000627:therapeutic use; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D005449:Fluorenes; D009285:Naphthoquinones; D011075:Polybrominated Biphenyls; D012367:RNA, Viral; D012118:Resorcinols; D014764:Viral Proteins; C003379:tebrofen; C007730:florenal; C011180:bonafton; C031970:2,4,6-triiodoresorcinol
Voprosy molekuliarnogo mekhanizma deĭstviia sinteticheskikh protivovirusnykh preparatov.