title: Rats administered chronic neuroleptics develop oral movements which are similar in form to those in humans with tardive dyskinesia.
abstract: Oral movements (OMs) in rats chronically administered haloperidol (HAL), fluphenazine (FLU), or no drug were recorded using a computerized video analysis system which measured the distance between two fluorescent dots painted above and below the rat's mouth. The resulting data was analyzed using fast-fourier analysis. Following an initial period of sedation (decreased energy at all frequencies), the drugged animals (and especially the FLU animals) began to show increased oral movements of 1-2 Hz, an effect which increased substantially upon drug withdrawal. This is precisely the altered energy spectrum observed in humans with tardive dyskinesia.
authors.affiliation: Department of Psychology, UCLA 90024.
authors.forename: G
authors.initials: G
authors.lastname: Ellison
authors.forename: R E
authors.initials: RE
authors.lastname: See
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004409:Dyskinesia, Drug-Induced / Q000523:psychology*; D005260:Female; D005583:Fourier Analysis; D009055:Mouth; D009069:Movement Disorders / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents