title: [Comparative pathomorphologic study of the toxic properties of a corpuscular pertussis vaccine and of a cell-free pertussis preparation].
abstract: The comparative study of morphological changes in the body of outbred mice under the action of corpuscular pertussis vaccine and acellular pertussis preparation has been made. The corpuscular vaccine has been shown to produce a pronounced, dynamically increasing toxic effect, thus causing the damage of lymphoid thymic and spleen cells, prolonged interstitial reaction in the lungs, destructive inflammatory process at the site of injection. The acellular pertussis preparation is less toxic, induces less pronounced changes in these organs at the early period of the experiment, stimulates the proliferation of lymphoid cells and lymphoblast transformation. As noted in this study, the damaging action of pertussis vaccine is mainly indicated by pathological phenomena appearing in the organs of the immune system, pulmonary parenchyma and muscular tissue (in the inoculation zone).
authors.forename: L V
authors.initials: LV
authors.lastname: Grigor'eva
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: A E
authors.initials: AE
authors.lastname: Chigirinskiĭ
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Koval'skaia
authors.forename: I G
authors.initials: IG
authors.lastname: Bazhanova
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000276:immunology / Q000633:toxicity*; D001886:Bordetella pertussis / Q000276:immunology / Q000472:pathogenicity*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000633:toxicity*; D013997:Time Factors; D014917:Whooping Cough / Q000276:immunology / Q000473:pathology / Q000517:prevention & control
chemical_list: D001685:Biological Factors; D010567:Pertussis Vaccine
vernacular_title: Sravnitel'noe patomorfologicheskoe izuchenie toksicheskikh svoĭstv korpuskuliarnoĭ kokliushnoĭ vaktsiny i beskletochnogo kokliushnogo preparata.