Genetic studies in Sjögren's syndrome and systemic lupus erythematosus.
HLA associations with Sjögren's syndrome (SS), previously defined by serologic HLA typing, are reviewed. Because the SS-A/Ro and SS-B/La autoantibody responses in SS and systemic lupus erythematosus (SLE) show even stronger correlations with HLA alleles, HLA-DR and DQ alleles were examined using restriction fragment length polymorphisms (RFLP) in white and black patients with SS and/or SS having anti-Ro and anti-La antibodies. The strongest associations across ethnic lines were with HLA-DR3, DQw2 and DQw1.2 (DQw6), especially the DQw1.2 (DQw6)/Dqw2 heterozygous state. HLA-DQw3 was relatively decreased. These data suggest that HLA-DQ is most likely responsible for these abnormal autoantibody responses. In addition, multiplex family studies of Ro antibodies demonstrates the requirement for both HLA and non-MHC effects.
Arnett
F C
FC
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
Bias
W B
WB
Reveille
J D
JD
D000906:Antibodies / Q000235:genetics; D000974:Antibodies, Antinuclear / Q000235:genetics; D001323:Autoantibodies / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D044469:Racial Groups; D012859:Sjogren's Syndrome / Q000235:genetics*
D000906:Antibodies; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006681:HLA-D Antigens; C035356:SS-A antibodies