Possible existence of a presynaptic positive feedback mechanism enhancing dopamine transmission in the anterior cingulate cortex of the rat.
A series of microiontophoretic and VTA stimulation experiments, conducted in intact, GBR-12909-treated, alpha-methylparatyrosine-depleted or 6-hydroxydopamine-denervated rats, provide suggestive evidence for the existence of a presynaptic, positive feedback mechanism triggered by dopamine reuptake and favoring the release of this transmitter in the anterior cingulate cortex.
Beauregard
M
M
Centre de Recherche en Sciences Neurologiques (Département de Physiologie), Faculté de Médecine, Université de Montréal, Québec, Canada.
Ferron
A
A
Descarries
L
L
D000818:Animals; D003714:Denervation; D004298:Dopamine / Q000378:metabolism*; D005246:Feedback; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000502:physiology; D014179:Neurotransmitter Uptake Inhibitors; D016627:Oxidopamine; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
D006892:Hydroxydopamines; D008781:Methyltyrosines; D014179:Neurotransmitter Uptake Inhibitors; D010879:Piperazines; D019805:alpha-Methyltyrosine; D016627:Oxidopamine; C043425:vanoxerine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine