Chrysotile A affects YAC-1 cytolytic activity of spleen cells.
Effect of short exposure of C57Bl/6 and F1/NZB x C57Bl/6/ mice to i.p. injected chrysotile A on YAC-1 cytolytic potential (NK cell function) of spleen cells was investigated. It was found that 3 days after injection, cytolytic activity of spleen cells was significantly abrogated and this was paralleled with an increase of alpha-naphtyl acetate esterase positive cells/macrophages in spleen cell population. In addition, effect of exposure of mice to i.p. injected chrysotile A coated with benzo(a)pyrene (BaP) was investigated. BaP did not modify the abrogative effect of chrysotile A on NK cell function. Asbestos fibres themselves were sufficient for depletion of NK cell function of spleen cells.
Moniewska
A
A
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Szyba
K
K
Jaźwiec
B
B
Lange
A
A
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D017632:Asbestos, Serpentine; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects / Q000276:immunology*
D017632:Asbestos, Serpentine; D001194:Asbestos