title: Susceptibility to acyclovir of herpes simplex virus: emergence of resistance in patients with lymphoid and myeloid neoplasia.
abstract: We have examined the susceptibility to acyclovir (ACV) of herpes simplex virus isolated from immunocompetent and immunocompromised patients. Susceptibility to ACV was determined in a dye-uptake assay with vero cells grown in 96-well microtitre plates. Resistant strains were found in two out of 35 (5.7%) patients and partially resistant strains in four out of 35 (11.4%) patients immunodeficient as a result of treatment for lymphoid or myeloid malignancy. Strains resistant to ACV were not found in organ transplant recipients or in immunocompetent patients.
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge, U.K.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gray
authors.forename: T G
authors.initials: TG
authors.lastname: Wreghitt
authors.forename: T P
authors.initials: TP
authors.lastname: Baglin
mesh_terms: D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D004352:Drug Resistance, Microbial; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy / Q000382:microbiology; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007108:Immune Tolerance; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000382:microbiology; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000187:drug effects*; D014181:Transplantation Immunology
chemical_list: D000212:Acyclovir