Inhibition of histamine release from rat hypothalamic slices by omega-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative.
Histamine release in response to 40 mM high K+-stimulation from the rat hypothalamic slice preparations perifused in vitro was significantly inhibited by 1.0 nM-1.0 microM omega-conotoxin GVIA, a peptide modulator of N- and L-type voltage-sensitive calcium channels, but not by similar concentrations of nilvadipine, a dihydropyridine derivative of L-type calcium channel antagonist. These results indicate that the voltage-sensitive calcium channel controlling histamine release from hypothalamic slices is omega-conotoxin-sensitive but dihydropyridine-insensitive.
Takemura
M
M
Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan.
Kishino
J
J
Yamatodani
A
A
Wada
H
H
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004095:Dihydropyridines / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008978:Mollusk Venoms / Q000494:pharmacology*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D008978:Mollusk Venoms; C035100:nilvadipine; D006632:Histamine; D020866:omega-Conotoxin GVIA; D009543:Nifedipine