Lack of platelet monoamine oxidase activity in Cebus monkeys (Cebus albifrons).
1. Recent evidence suggests that monoamine oxidase (MAO) plays an important role modulating the extrapyramidal syndromes produced by neuroleptic drugs in both human and nonhuman primates. 2. To evaluate the possibility of using peripheral blood platelet MAO-B levels as indices of central nervous system MAO-B effects, we measured platelet MAO-B levels in Cebus monkeys that were previously tested with neuroleptics (N = 36) or drug naive (N = 6). 3. No platelet MAO-B was consistently detectable in these blood samples. 4. Thus platelet measures of MAO-B do not reliably reflect brain MAO-B function in nonhuman primates and do not offer a useful model for studying blood-brain MAO-B relationships.
Heintz
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R
Dept. of Psychiatry, Oregon Health Sciences University, Portland.
Richardson
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Perumal
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Casey
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DE
D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D002427:Cebidae / Q000097:blood*; D002428:Cebus / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D010293:Pargyline / Q000494:pharmacology
D010293:Pargyline; D008995:Monoamine Oxidase