title: [Composite carcinoma of the prostate combining a small cell carcinoma and an adenocarcinoma. Apropos of a case].
abstract: A case of combined adenocarcinoma and small cell carcinoma of the prostate is described in a 58-year-old-man. Prostatic acid phosphatases and neuron specific enolase were found elevated in the serum. At autopsy the lung was free of tumor. The liver was replaced by numerous metastatic nodules and a voluminous mesenteric metastasis extended into the wall of the vessels (aorta and vena cava). Microscopic examination showed a small cell carcinoma component of the oat cell type and an adenocarcinoma component constituting 10% of the total tumor volume. By immunostaining, the small cell carcinoma component is neuron specific enolase+ and prostatic specific antigen-. The adenocarcinoma component is neuron specific enolase- and prostatic specific antigen+.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Centre Hospitalier Régional, Hôpital Saint-Jacques, Clermont-Ferrand.
authors.forename: B
authors.initials: B
authors.lastname: Kantelip
authors.forename: J L
authors.initials: JL
authors.lastname: Viallard
authors.forename: N
authors.initials: N
authors.lastname: Costes-Chalret
authors.forename: P
authors.initials: P
authors.lastname: Francannet
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis*; D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000473:pathology*
chemical_list: D000135:Acid Phosphatase; D010751:Phosphopyruvate Hydratase
vernacular_title: Carcinome composite de la prostate associant carcinome à petites cellules et adénocarcinome. A propos d'un cas.