Short-term somatostatin infusion affects T lymphocyte responsiveness in humans.
Peripheral blood lymphocytes (PBL) function was analysed in 16 young men with duodenal ulcers after one-hour intravenous infusion of somatostatin (SMS) at a dose of 250 micrograms/h. Proliferative responses of PBL from SMS-treated patients were significantly diminished compared with pre-treatment values, after stimulation with PHA, PWM or Con A. Spontaneous IL-2R expression was moderately increased after SMS infusion but PHA-induced IL-2R expression was not affected by this drug. Alloantigen and autoantigen stimulation of PBL showed no significant changes in the proliferative response after SMS infusion. NK cell activity was similarly unaffected. These observations establish a link between SMS exposure and possible development of immune dysfunction.
Malec
P
P
1st Department of Internal Medicine, School of Medicine, Lódź, Poland.
Zeman
K
K
Markiewicz
K
K
Tchórzewski
H
H
Nowak
Z
Z
Baj
Z
Z
D000328:Adult; D004381:Duodenal Ulcer / Q000276:immunology; D006801:Humans; D007262:Infusions, Intravenous; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D015213:Neuroimmunomodulation / Q000187:drug effects; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis / Q000187:drug effects; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D008934:Mitogens; D015375:Receptors, Interleukin-2; D013004:Somatostatin