title: Predisposition to familial osteoarthrosis linked to type II collagen gene.
abstract: The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.
authors.affiliation: Laboratory of Molecular Genetics, National Public Health Institute, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Palotie
authors.forename: P
authors.initials: P
authors.lastname: Väisänen
authors.forename: J
authors.initials: J
authors.lastname: Ott
authors.forename: L
authors.initials: L
authors.lastname: Ryhänen
authors.forename: K
authors.initials: K
authors.lastname: Elima
authors.forename: M
authors.initials: M
authors.lastname: Vikkula
authors.forename: K
authors.initials: K
authors.lastname: Cheah
authors.forename: E
authors.initials: E
authors.lastname: Vuorio
authors.forename: L
authors.initials: L
authors.lastname: Peltonen
mesh_terms: D000328:Adult; D000367:Age Factors; D002881:Chromosomes, Human, Pair 12; D003094:Collagen / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011859:Radiography; D012720:Severity of Illness Index
chemical_list: D003094:Collagen; D004247:DNA