[Comparative analysis of sequences of protein D2 from photosystem 2 reaction center and various Ca 2+-binding proteins].
The amino acid sequence of D2 protein was compared with those of calcium binding proteins and receptor for calcium channel blockers in connection with the data showing the participation of Ca2+ in photosystem 2 electron transport and the inhibition of this process by calmodulin antagonists, calcium channel blockers and local anesthetics. Protein D2 possesses a pattern analogous to the "EF-hand" sites of the calcium binding proteins. Comparison of the amino acid sequence of the calmodulin fragment binding the phenothiazine type calmodulin antagonists with the amino acid sequence of D2 protein and calcium channel protein revealed a high degree of sequence identity. Common structural features take place also between the membrane spanning segment III of D2 protein, which contains the tyrosine residue (161), responsible for ESR-signal IIS, and the membrane segment IVS5 of calcium channel protein. A model explaining the mechanism of calcium function in the oxygen-evolving system is proposed.
Semin
B K
BK
Ivanov
I I
II
Rubin
A B
AB
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels; D002135:Calcium-Binding Proteins / Q000032:analysis* / Q000235:genetics; D002147:Calmodulin / Q000032:analysis / Q000235:genetics; D002734:Chlorophyll / Q000032:analysis* / Q000235:genetics; D004578:Electron Spin Resonance Spectroscopy; D045342:Light-Harvesting Protein Complexes; D008969:Molecular Sequence Data; D045322:Photosynthetic Reaction Center Complex Proteins; D010940:Plant Proteins / Q000032:analysis* / Q000235:genetics; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000032:analysis / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D045342:Light-Harvesting Protein Complexes; D045322:Photosynthetic Reaction Center Complex Proteins; D010940:Plant Proteins; D011978:Receptors, Nicotinic; D002734:Chlorophyll
Sravnitel'nyĭ analiz posledovatel'nosteĭ belka D2 reaktsionnogo tsentra fotosistemy 2 i nekotorykh Ca 2+-sviazyvaiushchikh belkov.