[Composite carcinoma of the prostate combining a small cell carcinoma and an adenocarcinoma. Apropos of a case].
A case of combined adenocarcinoma and small cell carcinoma of the prostate is described in a 58-year-old-man. Prostatic acid phosphatases and neuron specific enolase were found elevated in the serum. At autopsy the lung was free of tumor. The liver was replaced by numerous metastatic nodules and a voluminous mesenteric metastasis extended into the wall of the vessels (aorta and vena cava). Microscopic examination showed a small cell carcinoma component of the oat cell type and an adenocarcinoma component constituting 10% of the total tumor volume. By immunostaining, the small cell carcinoma component is neuron specific enolase+ and prostatic specific antigen-. The adenocarcinoma component is neuron specific enolase- and prostatic specific antigen+.
Kantelip
B
B
Laboratoire d'Anatomie Pathologique, Centre Hospitalier Régional, Hôpital Saint-Jacques, Clermont-Ferrand.
Viallard
J L
JL
Costes-Chalret
N
N
Francannet
P
P
D000135:Acid Phosphatase / Q000032:analysis*; D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000473:pathology*
D000135:Acid Phosphatase; D010751:Phosphopyruvate Hydratase
Carcinome composite de la prostate associant carcinome à petites cellules et adénocarcinome. A propos d'un cas.