Chromosomal mapping of the mouse IL-4 and human IL-5 genes.
We mapped the mouse interleukin (IL)-4 gene on chromosome 11 by restriction fragment length polymorphism using recombinant inbred mouse strains. The human IL-5 gene was mapped on chromosome 5q 23.3-31.1 by in situ hybridization. Because the granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-3 genes were previously mapped on mouse chromosome 11 (within a 230-kb region) and human chromosome 5, the IL-4 and IL-5 genes are likely to cluster on the same chromosomes with the GM-CSF and IL-3 genes in both species.
Takahashi
M
M
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
Yoshida
M C
MC
Satoh
H
H
Hilgers
J
J
Yaoita
Y
Y
Honjo
T
T
D000818:Animals; D002895:Chromosomes, Human, Pair 5; D003115:Colony-Stimulating Factors / Q000235:genetics; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics; D015847:Interleukin-4; D015848:Interleukin-5; D007378:Interleukins / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D015183:Restriction Mapping
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007377:Interleukin-3; D015848:Interleukin-5; D007378:Interleukins; D015847:Interleukin-4; D016178:Granulocyte-Macrophage Colony-Stimulating Factor