title: Large cell neuroendocrine carcinoma of the lung.
abstract: Large cell neuroendocrine (LCNE) carcinomas of the lung are a newly recognized, highly aggressive and frequently misdiagnosed entity. We report a case of stage I LCNE lung carcinoma initially misdiagnosed as large cell undifferentiated carcinoma or poorly differentiated adenocarcinoma. The tumor was very extensively necrotic and its neuroendocrine differentiation was only demonstrable with immunohistochemical staining with PHE-5 monoclonal antibody and with antisera against synaptophysin and calcitonin. ACTH, somatostatin and neurofilaments were not demonstrable. The clinical course was ominous and the patient died within 17 months. The reason for this rapid fatal outcome could be ascribed either to the neuroendocrine phenotype of the tumor, or to the extensive necrosis, or both.
authors.affiliation: 3rd Chair of Morbid Anatomy and Histopathology, School of Medicine, State University of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Barbareschi
authors.forename: C
authors.initials: C
authors.lastname: Mariscotti
authors.forename: M
authors.initials: M
authors.lastname: Barberis
authors.forename: B
authors.initials: B
authors.lastname: Frigo
authors.forename: L
authors.initials: L
authors.lastname: Mosca
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D000911:Antibodies, Monoclonal; D001859:Bone Neoplasms / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000473:pathology*; D002843:Chromatin / Q000032:analysis; D003937:Diagnosis, Differential; D005266:Femoral Neoplasms / Q000556:secondary; D006801:Humans; D007106:Immune Sera; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging
chemical_list: D000911:Antibodies, Monoclonal; D002843:Chromatin; D007106:Immune Sera