[Role of sex dimorphism in the pharmacological action of etimizol].
It has been shown that in female rats the level of ACTH, corticosterone in the blood, relative mass of adrenals, maintenance of T3, T4 in the serum and liver was significantly higher, but the activity of liver enzyme microsomes system was lower than in males; no sex differences were observed in myocardial creatine phosphokinase system. The influence of the etimizol on the female rats significantly speed up amidopyrine N-demethylation and biotransformation of hexobarbital. In males these systems react less on etimizol, but it reduces the speed of amidopyrine N-demethylation.
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D000311:Adrenal Glands / Q000033:anatomy & histology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D003345:Corticosterone / Q000097:blood; D003402:Creatine Kinase / Q000378:metabolism; D005042:Etimizol / Q000494:pharmacology*; D005260:Female; D006591:Hexobarbital / Q000493:pharmacokinetics; D007093:Imidazoles / Q000494:pharmacology*; D008099:Liver / Q000032:analysis / Q000201:enzymology; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D012727:Sex Characteristics; D013963:Thyroid Hormones / Q000032:analysis / Q000097:blood
D007093:Imidazoles; D013963:Thyroid Hormones; D000632:Aminopyrine; D000324:Adrenocorticotropic Hormone; D006591:Hexobarbital; D003402:Creatine Kinase; D005042:Etimizol; D003345:Corticosterone
Rol' polovogo dimorfizma v farmakologicheskom éffekte étimizola.