Neuroendocrine effects of ovine corticotropin-releasing hormone in panic disorder patients.
A number of neuroendocrine abnormalities have been reported in panic disorder patients: the most extensively studied being disturbances of hypothalamic-pituitary-adrenal function (Curtis et al. 1982; Leiberman et al. 1983; Uhde et al. 1988). The recent sequencing and synthesis of corticotropin-releasing hormone now allows direct testing of pituitary responsivity to this neuropeptide in affective and panic disorder patients (Holsboer et al. 1984; Gold et al. 1986; Roy-Byrne et al. 1986; Holsboer et al. 1987; Risch et al. 1988). We report the effects of intravenously administered ovine corticotropin-releasing hormone (0.03 micrograms/kg) on plasma concentrations of adrenocorticotropin hormone (ACTH) and cortisol in a small group of panic disorder patients and age- and sex-matched normal controls.
Rapaport
M H
MH
Clinical Neuroscience Branch, NIMH, Bethesda, MD 20892.
Risch
S C
SC
Golshan
S
S
Gillin
J C
JC
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D003346:Corticotropin-Releasing Hormone; D005239:Fear / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007262:Infusions, Intravenous; D010200:Panic / Q000502:physiology*; D011863:Radioimmunoassay
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone