Neuroleptic nonresponse and affective symptoms: a 2-year prospective study of schizophrenic outpatients.
For 2 years we assessed clinical state, and plasma neuroleptic and prolactin levels every 6 months in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. Those who had psychotic symptoms at 50% or more of their visits had higher neuroleptic doses, more tardive dyskinesia, and more affective symptoms than the other patients. These groups were not, however, significantly different in their age of onset, years of education, duration of illness, duration of neuroleptic exposure, or negative symptoms.
Faraone
S V
SV
Brockton-West Roxbury VA Medical Center, MA 02401.
Young
A S
AS
Brown
W A
WA
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents