Molecular epidemiology of human rotavirus infection in Coro, Venezuela.
From December 1984 to December 1987, rotaviruses were detected in 115 (24%) of 470 hospitalized children, by electrophoretic analysis of viral RNA. Three peaks of increased incidence were observed, coincident with the cooler months of each year. Rotavirus was found in 31% of the children with diarrhea and in 47% of those who were severely dehydrated. Vomiting was significantly associated with rotavirus shedding in diarrheic children. Eleven electropherotypes were identified, showing a sequential pattern of appearance. Strains exhibiting a "short" pattern were present in 10% of the positive cases. The rate of infection increased to 71% in march 1987, when a mixed infection with two genotypically different strains was found and when electropherotypes with an extra RNA segment appeared.
Urquidi
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D002675:Child, Preschool; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology*; D012621:Seasons; D014687:Venezuela
D012367:RNA, Viral