A genetic linkage map of 17 markers on human chromosome 21.
We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was approximately twice that in males between proximal markers. However, over half of the recombination events in either sex occur distally, in 21q22.3, although this region accounts for only about 15% of the physical length of chromosome 21.
Warren
A C
AC
Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Slaugenhaupt
S A
SA
Lewis
J G
JG
Chakravarti
A
A
Antonarakis
S E
SE
D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
D015342:DNA Probes; D005819:Genetic Markers