[Insulin regulation of 2 kinetically different types of calcium current].
At least two kinetically different kinds of calcium current are shown to exist in the frog atrial cells. The current with faster activation kinetics is usually depressed by insulin. Insulin also increases the amplitude of the slower calcium current. Pretreatment of atrial cells with cycloheximide does not change the effect of insulin on the fast calcium current but dramatically facilitates the insulin-induced activation of the slower calcium current.
Nakipova
O V
OV
Lazarev
A V
AV
Kshutashvili
T Sh
TSh
Krupenin
V A
VA
Freĭdin
A A
AA
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D016275:Atrial Function; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D003513:Cycloheximide / Q000494:pharmacology; D004347:Drug Interactions; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D011895:Rana ridibunda; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology*
D015220:Calcium Channels; D007328:Insulin; D001224:Aspartic Acid; D013779:Tetrodotoxin; D003513:Cycloheximide; D015032:Zinc; D007545:Isoproterenol
Reguliatsiia insulinom dvukh kineticheski razlichnykh tipov kal'tsievogo toka.