title: Anticoagulant activity of immobilized thrombomodulin.
abstract: Bovine lung thrombomodulin was partially purified, and immobilized on agarose gel (Sepharose 4B). Immobilized thrombomodulin inhibited the procoagulant activity of thrombin, and enhanced the thrombin-catalyzed protein C activation. The plasma recalcification time test showed that immobilized thrombomodulin prolonged plasma clotting time. It is suggested that the immobilization of thrombomodulin will provide an antithrombogenic biomaterial able to convert thrombin from a procoagulant to an anticoagulant enzyme.
authors.forename: K
authors.initials: K
authors.lastname: Yagi
authors.forename: K
authors.initials: K
authors.lastname: Hirota
authors.forename: S
authors.initials: S
authors.lastname: Yamasaki
authors.forename: A
authors.initials: A
authors.lastname: Uwai
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D000818:Animals; D000925:Anticoagulants; D002417:Cattle; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000494:pharmacology*; D018179:Receptors, Thrombin
chemical_list: D000925:Anticoagulants; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin