Dietary habits and prognostic factors in breast cancer.
The relationship between dietary habits and prognostic factors for breast cancer was studied in 240 women aged 50-65 years who had surgery for breast cancer between 1983 and 1986. A dietary history interview was conducted within the 4 months following resection of the primary tumor. In the stepwise multivariate analysis, the multiple-odds ratio (OR) for having a tumor greater than or equal to 20 mm in diameter was 0.95 (95% confidence interval, 0.91-0.99) for each 1-g increase in fiber intake per 10 MJ of energy intake. Compared with patients having tumors poor in estrogen receptor (ER), those having ER-rich tumors (greater than or equal to 0.10 fmol/microgram of DNA) were older (P less than .01) and reported carbohydrate intake yielding higher E% (percentage of total energy intake) (P less than .01) and higher retinol intake per 10 MJ (P less than .05). The OR for having an ER-rich tumor was 1.58 (95% confidence interval, 1.08-2.31) for each 1-mg increase in retinol intake per 10 MJ; 1.09 (95% confidence interval, 1.02-1.16) for each additional year of age; and 1.08 (95% confidence interval, 1.02-1.13) for each 1% increment in E% from carbohydrates. These results suggest that the dietary patterns of the western world (e.g., high fat intake and low intake of carbohydrates and fiber) affect certain prognostic factors in breast cancer, such as tumor size and ER content of the tumor.
Holm
L E
LE
Department of Cancer Prevention, Karolinska Hospital, Stockholm, Sweden.
Callmer
E
E
Hjalmar
M L
ML
Lidbrink
E
E
Nilsson
B
B
Skoog
L
L
D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004034:Diet Surveys; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D002149:Energy Intake; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis / Q000378:metabolism; D012307:Risk Factors; D014801:Vitamin A / Q000008:administration & dosage
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D005229:Fatty Acids, Monounsaturated; D011960:Receptors, Estrogen; D014801:Vitamin A