title: Mucosal epithelial cells and Langerhans cells are targets for infection by the immunosuppressive type D retrovirus simian AIDS retrovirus serotype 1.
abstract: Simian acquired immune deficiency syndrome (SAIDS) caused by the type D retrovirus SRV-1 results in opportunistic infections and a spectrum of oral lesions similar to those seen in humans with AIDS. To better understand the pathogenesis of these oral lesions we have retrospectively examined the oral mucosa from ten rhesus monkeys that died with SAIDS and prospectively examined the oral mucosa of ten additional animals inoculated with SRV-1 to determine at what time, and in what cells SRV-1 infection of the oral mucosa occurs. Using single and double label immunohistologic techniques, and electron microscopy we detected SRV-1 in clusters of oral epithelial cells and rare Langerhans cells as early as 1 month postinoculation.
authors.affiliation: California Primate Research Center, University of California, Davis.
authors.forename: A A
authors.initials: AA
authors.lastname: Lackner
authors.forename: M
authors.initials: M
authors.lastname: Schiødt
authors.forename: G C
authors.initials: GC
authors.lastname: Armitage
authors.forename: P F
authors.initials: PF
authors.lastname: Moore
authors.forename: R J
authors.initials: RJ
authors.lastname: Munn
authors.forename: P A
authors.initials: PA
authors.lastname: Marx
authors.forename: M B
authors.initials: MB
authors.lastname: Gardner
authors.forename: L J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D007801:Langerhans Cells / Q000382:microbiology*; D008253:Macaca mulatta; D008854:Microscopy, Electron; D008992:Monkey Diseases / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology*; D009960:Oropharynx / Q000382:microbiology; D011446:Prospective Studies; D012189:Retrospective Studies; D012192:Retroviridae Infections / Q000382:microbiology / Q000662:veterinary*; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification* / Q000648:ultrastructure; D014059:Tongue / Q000382:microbiology; D014771:Virion / Q000302:isolation & purification