Microbial synthesis of metabolites with antihypertensive activity: aspects of fermentation derived inhibitors of angiotensin-converting enzyme (ACE).
In this review the microbial angiotensin-converting enzyme inhibitors are described. Especially from the microbiological point of view the characteristics of these metabolites are given, e.g. occurrence, fermentation physiology and specificity. Besides these data, the structure, assays and some isolation problems are summarised. Apart from ACE inhibition the different biological activities of these secondary metabolites are discussed.
Manthey
A
A
Friedrich-Schiller-Universität, Mikrobielle Biochemie, Jena, DDR.
Reuter
G
G
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis / Q000378:metabolism* / Q000627:therapeutic use; D001419:Bacteria / Q000378:metabolism*; D005285:Fermentation; D007703:Peptidyl-Dipeptidase A / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D007703:Peptidyl-Dipeptidase A