[Dipeptidyl aminopeptidase-IV in lymphocytes of patients with lymphoproliferative diseases].
DAP-IV activity (Gly-Pro-MCA hydrolysis, pH 7.8) was found in lysates of peripheral blood lymphocytes of patients with T- and B-cell forms of malignant lymphoproliferative diseases. The highest DAP-IV activity was seen in the cells of patients with a rare variant of T-cell lymphocytic leukemia (T-CLL); these cells expressed simultaneously the antigens of T helpers and T suppressors (Th and Ts) (OKT4+ and OKT8+). The DAP-IV activity about ten times less was found in the pathological cells with a phenotype of mature Th (Sezary disease), as well as in the cells expressing antigens of both Ts and natural killers (a rare variant of T-CLL). The same activity was also found in Ts (T gamma-lymphocytosis). The data obtained show that the differences in DAP-IV expression are connected with the differentiation step rather than with the belonging to a particular subpopulation of T-cells. DAP-IV activity, which was somewhat lower than that of T-cells, was found in B-lymphocytes of patients with B-CLL, hair-cellular leukemia, and non-Hodgkin's lymphoma. No correlation of DAP-IV activity with the level of E-cellular differentiation was observed.
Bylinkina
V S
VS
Golubeva
N V
NV
Gureeva
T A
TA
Lokshina
L A
LA
Polianskaia
A M
AM
Samoĭlova
R S
RS
D000941:Antigens / Q000032:analysis; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007938:Leukemia / Q000201:enzymology* / Q000276:immunology; D007943:Leukemia, Hairy Cell / Q000201:enzymology / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology / Q000276:immunology; D015461:Leukemia, Prolymphocytic, T-Cell / Q000201:enzymology / Q000276:immunology; D008214:Lymphocytes / Q000201:enzymology*; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology* / Q000276:immunology; D012751:Sezary Syndrome / Q000201:enzymology* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000941:Antigens; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4
Dipeptidilaminopeptidaza-IV v limfotsitakh bol'nykh limfoproliferativnymi zabolevaniiami.