title: Influence of the placenta on fetal plasma insulin and neonatal hepatic enzyme induction in the rat.
abstract: In order to study the placental role in controlling glucose metabolism and neonatal induction of tyrosine aminotransferase in rat liver, a comparison was made between the artificially delivered-rat feto-placental unit and the newborn littermates. The immunoreactive serum insulin in the feto-placental unit remains as high as in utero for at least 1 h whereas in the newborn rat it decreases rapidly after delivery. From Caesarian section to 6 h later, in contrast to the newborn littermates, the feto-placental unit remains hyperglycaemic. Upon glucagon injection the feto-placental unit shows a delay in the increase of the hepatic tyrosine aminotransferase activity in comparison with the newborn rat.
authors.affiliation: Karl-Marx University, School of Medicine, Institute of Biochemistry, Leipzig, GDR.
authors.forename: W
authors.initials: W
authors.lastname: Goltzsch
authors.forename: E
authors.initials: E
authors.lastname: Niemann
authors.forename: H J
authors.initials: HJ
authors.lastname: Böhme
authors.forename: E
authors.initials: E
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D004790:Enzyme Induction; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D014444:Tyrosine Transaminase