Fatal hepatic necrosis caused by disseminated type 5 adenovirus infection in a renal transplant recipient.
This is an unusual case of fatal hepatic necrosis caused by disseminated type 5 adenovirus in a renal transplant recipient. This adult patient may have been colonized at the time of transplantation with a kidney from a pediatric donor. The adenovirus became invasive when the host's cellular immune system was suppressed by high doses of corticosteroids given to reverse acute allograft rejection.
Norris
S H
SH
Department of Internal Medicine, Texas Tech University Health Sciences Center School of Medicine, Lubbock.
Butler
T C
TC
Glass
N
N
Tran
R
R
D000257:Adenoviridae Infections / Q000150:complications*; D000258:Adenovirus Infections, Human / Q000150:complications*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D009894:Opportunistic Infections / Q000150:complications*
D007166:Immunosuppressive Agents