Immunohistology of the skin rash associated with acute HIV infection.
An immunohistological study of the rash associated with acute HIV infection in a homosexual man was undertaken. The salient feature was an infiltrate of mononuclear cells predominantly of the CD4+ phenotype around the superficial dermal vessels. HIV p24 antigen was detected in occasional cells, possibly Langerhans' cells, of the infiltrate. Their presentation of HIV antigen to local CD4+ cells may lead to a delayed type hypersensitivity reaction.
McMillan
A
A
Department of Medicine, University of Edinburgh, UK.
Bishop
P E
PE
Aw
D
D
Peutherer
J F
JF
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000208:Acute Disease; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006716:Homosexuality; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012191:Retroviridae Proteins / Q000032:analysis; D012867:Skin / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology
D015488:HIV Antigens; D016655:HIV Core Protein p24; D012191:Retroviridae Proteins