title: Stimulation of clones specific for dsDNA or idiotypes of anti-dsDNA as a consequence of BK virus inoculation.
abstract: The human polyoma virus BK (BKV) has a 5 Kbp double-stranded (ds) DNA genome packed with host cell histones into a minichromosome. Two out of 5 rabbits inoculated with infectious BKV produced detectable anti-dsDNA antibodies. In two additional rabbits antibodies against idiotypes of anti-dsDNA antibodies were elicited. These findings strongly indicate the existence of immunocompetent anti-dsDNA clones which are regulated, at least in part, through a network mechanism by anti-idiotype antibodies.
authors.affiliation: Department of Immunology, University of Tromsø School of Medicine, Norway.
authors.forename: O P
authors.initials: OP
authors.lastname: Rekvig
authors.forename: T
authors.initials: T
authors.lastname: Flaegstad
authors.forename: K
authors.initials: K
authors.lastname: Fredriksen
authors.forename: T
authors.initials: T
authors.lastname: Traavik
mesh_terms: D000818:Animals; D001739:BK Virus / Q000276:immunology*; D002999:Clone Cells; D004247:DNA / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007140:Immunoglobulin Fab Fragments / Q000302:isolation & purification; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D011120:Polyomavirus / Q000276:immunology*; D011817:Rabbits; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; D004247:DNA