[Does ethanol potentiate GABAergic inhibition?].
The effect of systemically and microelectro-osmotically applied ethanol on sensitivity of sensorimotor cortical neurons of unanesthetized rabbit brain to microiontophoretically administered GABA and glycine was studied. No correlation was found between responses of single neurons to ethanol, GABA and glycine. The inhibitory responses to ethanol were summed with responses to GABA and glycine (additive interaction). Ethanol failed to potentiate GABA effect.
Kozhechkin
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology; D007478:Iontophoresis; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D011963:Receptors, GABA-A; D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D005998:Glycine
Potentsiruet li étanol GAMK-ergicheskoe tormozhenie?