[Synergic effect of 5-fluorocytosine and imidazole derivatives against yeast strains resistant to 5-fluorocytosine].
Antifungal agents associations are widely used in therapy of deep mycotic diseases, particularly amphotericin B-5-fluorocytosine association. Synergistic effect has also been described between 5-fluorocytosine and imidazole derivates. The authors have tested here eventual synergy between 5-fluorocytosine and imidazole derivatives (miconazole, ketoconazole, fluconazole, itraconazole) against 57 years isolates resistant to 5-fluorocytosine by a semi-automated methods in liquid medium (Yeast Nitrogen Base and Brain Heart Infusion). The synergistic effect between 5-fluorocytosine and antifungal imidazoles varies widely with the drug tested. It's more frequent with ketoconazole. Itraconazole and fluconazole present very little synergistic effects in vitro.
Mary
C
C
Laboratoire de Parasitologie Mycologie, Faculté de Médecine, Marseille.
Goudard
M
M
Blancard
A
A
Quilici
M
M
Regli
P
P
D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004357:Drug Synergism; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D007093:Imidazoles; D017964:Itraconazole; D008825:Miconazole; D015725:Fluconazole; D005437:Flucytosine; D007654:Ketoconazole
Effet synergique entre la 5-flurocytosine et les dérivés imidazolés vis-à-vis de souches de levures résistantes à la 5-fluorocytosine.