title: Duodenal somatostatinoma with psammoma bodies.
abstract: A duodenal somatostatinoma was found incidentally in a 60-year-old woman undergoing cholecystectomy. Microscopically, the tumor had a glandular architecture with abundant psammoma bodies. Electron microscopy revealed tumor cells resembling D-cells of the pancreatic islets. Immunohistochemically, there was staining for neuron-specific enolase, chromogranin, and diffuse cytoplasmic positivity for somatostatin only. By immunoelectron microscopy, somatostatin was identified predominantly in lucent membrane-bound secretory granules. X-ray-dispersive microanalysis showed the psammoma bodies contained calcium apatite crystals. This case is compared with other reported cases with a description of cellular localization of somatostatin and development of psammomatous calcification.
authors.affiliation: Department of Pathology, St Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Albrecht
authors.forename: G W
authors.initials: GW
authors.lastname: Gardiner
authors.forename: K
authors.initials: K
authors.lastname: Kovacs
authors.forename: G
authors.initials: G
authors.lastname: Ilse
authors.forename: U
authors.initials: U
authors.lastname: Kaiser
mesh_terms: D007516:Adenoma, Islet Cell / Q000648:ultrastructure*; D001031:Apatites / Q000032:analysis; D002114:Calcinosis; D002118:Calcium / Q000032:analysis; D004379:Duodenal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000032:analysis / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron / Q000379:methods; D008875:Middle Aged; D013004:Somatostatin / Q000378:metabolism; D013005:Somatostatinoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*
chemical_list: D001031:Apatites; D013004:Somatostatin; D002118:Calcium