title: Different haplotypes for cystic fibrosis-linked DNA polymorphisms in Polish and Dutch populations.
abstract: We analyzed DNA from 34 Polish and 63 Dutch cystic fibrosis (CF) patients and their families using the polymorphic markers XV2c and KM19, which are in linkage disequilibrium with the CF mutation. Strong linkage disequilibrium was found in the Dutch population sample, but the haplotypes of the Polish chromosomes showed a significantly less extreme disequilibrium. Our data and previous studies indicate that the highest degree of homogeneity of the CF defect and hence the best possible use of the XV2c/KM19/CF linkage disequilibrium for CF carrier detection/exclusion is in populations of northern European origin.
authors.affiliation: National Research Institute of Mother and Child, Department of Genetics, Warsaw, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Maciejko
authors.forename: J
authors.initials: J
authors.lastname: Bal
authors.forename: T
authors.initials: T
authors.lastname: Mazurczak
authors.forename: G
authors.initials: G
authors.lastname: te Meerman
authors.forename: C
authors.initials: C
authors.lastname: Buys
authors.forename: B
authors.initials: B
authors.lastname: Oostra
authors.forename: D
authors.initials: D
authors.lastname: Halley
mesh_terms: D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009426:Netherlands; D011044:Poland; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004247:DNA