Human herpesvirus 6 infection and Kawasaki disease.
Eighteen of a total of 22 serum specimens (81.8%) from patients with Kawasaki disease were positive for immunoglobulin G or M antibodies to human herpesvirus 6, whereas 10 of 16 age- and sex-matched healthy controls (62.5%) were seropositive. Additionally, increased geometric mean antibody titers of immunoglobulin G were shown in these patients. These results suggest that the status of human herpesvirus 6 infection may be a reflection of the immunologic alterations that are associated with Kawasaki disease.
Okano
M
M
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105-1065.
Luka
J
J
Thiele
G M
GM
Sakiyama
Y
Y
Matsumoto
S
S
Purtilo
D T
DT
D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D006564:Herpesviridae / Q000145:classification / Q000276:immunology; D006566:Herpesviridae Infections / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000276:immunology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M