The possible role of endogenous digitalis-like substance in the regulation of circadian changes in urinary electrolyte excretion in man.
The urinary volume (U.V.), Na excretion (UNaV) and K excretion (UKV) have been reported to show a circadian rhythm in man, but the mechanism of this rhythm has not been made clear. To investigate how atrial natriuretic peptide (ANP) and endogenous digitalis-like substance (DLS) participate in the circadian change in urinary electrolyte, the circadian changes in ANP and DLS (digoxin-like immunoactivity: DLI, Na-K-ATPase inhibitor: ATPI, ouabain binding inhibitor to Na-K-ATPase: OBI) were evaluated in 5 normal man. ANP, DLI and OBI showed no significant correlation with urinary electrolyte excretion, but there was a significant positive correlation between plasma ATPI and urinary Na excretion. From these results it is suggested that circulating Na-K-ATPase inhibitor (plasma ATPI) may be involved in the regulation of the circadian rhythm of urinary Na excretion.
Morise
T
T
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Okamoto
S
S
Ikeda
M
M
Takeda
R
R
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D001798:Blood Proteins / Q000502:physiology* / Q000652:urine; D002298:Cardenolides; D002940:Circadian Rhythm; D004077:Digoxin; D006801:Humans; D008297:Male; D010042:Ouabain / Q000097:blood / Q000652:urine; D011188:Potassium / Q000097:blood / Q000652:urine*; D012503:Saponins; D012964:Sodium / Q000097:blood / Q000652:urine*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000652:urine
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D010042:Ouabain; D004077:Digoxin; D009320:Atrial Natriuretic Factor; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium