In vitro inhibition of prostaglandin H synthase by compounds from the exocrine secretions of lace bugs.
1. Selected lace bug-derived and related compounds were shown to be in vitro inhibitors of mammalian and insect derived prostaglandin H synthase. 2. Two compounds, 2,6-dihydroxyacetophenone and 2,4,6-trihydroxyacetophenone, were significantly better inhibitors of prostaglandin synthesis than aspirin, whereas 2-nonyl-5,7-dihydroxychromone and 1-(2,6-dihydroxyphenyl) dodecan-1-one were equivalent to aspirin. 3. 2,4-Dihydroxyacetophenone was less effective in inhibiting the prostaglandin H synthase and 2-nonyl-5-hydroxychromanone showed no inhibition. 4. Three compounds, 2,6-dihydroxyacetophenone, 2,4,6-trihydroxyacetophenone and 1-(2,6-dihydroxyphenyl) dodecan-1-one were equal to aspirin in PSI inhibition with fat body preparations of the American cockroach Periplaneta americana L.
Jurenka
R A
RA
Department of Biochemistry, University of Nevada-Reno 89557-0014.
Neal
J W
JW
Howard
R W
RW
Oliver
J E
JE
Blomquist
G J
GJ
D000818:Animals; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D005088:Exocrine Glands / Q000378:metabolism; D006430:Hemiptera / Q000378:metabolism*; D066298:In Vitro Techniques; D010526:Periplaneta / Q000201:enzymology
D016861:Cyclooxygenase Inhibitors