title: The pathology of the amyloid A4 precursor of Alzheimer's disease.
abstract: The A4 amyloid protein is the major subunit present in the amyloid of Alzheimer's disease. It is derived by proteolytic cleavage from a larger precursor (PreA4) which is a neuronal membrane glycoprotein. Whereas in Down's syndrome, over-expression of the gene coding for PreA4 is likely to be responsible for the premature development of cerebral amyloidosis, a similar mechanism is yet to be demonstrated in Alzheimer's disease.
authors.affiliation: Department of Pathology, University of Melbourne, Australia.
authors.forename: C L
authors.initials: CL
authors.lastname: Masters
authors.forename: K T
authors.initials: KT
authors.lastname: Beyreuther
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000686:Amyloidosis / Q000235:genetics; D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D011956:Receptors, Cell Surface