Isolation of herpes simplex virus type 1 during first attack of multiple sclerosis.
Herpes simplex virus type 1 was isolated from the cerebrospinal fluid of a patient during the first attack of multiple sclerosis. This is the first virus to be isolated from the central nervous system of a living patient with MS. The virus was identified as herpes simplex virus type 1 by restriction endonuclease analysis and by an enzyme immunoassay using monoclonal antibodies. Antibodies against type 1 but not type 2 were detected in consecutive samples of serum and cerebrospinal fluid. The patient has since entered a progressive phase of multiple sclerosis. The isolated type 1 strain might be of pathogenetic relevance to the development of multiple sclerosis in this patient.
Bergström
T
T
Department of Clinical Virology, University of Göteborg, Sahlgrens Hospital, Sweden.
Andersen
O
O
Vahlne
A
A
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000382:microbiology*; D018139:Simplexvirus / Q000302:isolation & purification*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral