Differential influences of corticotropin-releasing factor on memory retention of aversive learning and appetitive learning in rats.
The effects of intraamygdala injections of corticotropin-releasing factor (CRF) on memory retention of aversive and appetitive learnings were examined in the present study. Other than confirming the results of a previous study that a moderate dose of CRF (0.1 microgram) injected into the amygdala facilitated retention performance of an inhibitory avoidance task (electric shock punishment) 24 h after training, we have further found that this effect lasted for a week. However, CRF produced a differential dose-response effect upon memory of an appetitive learning paradigm (sexual reinforcement). CRF at 0.01 microgram enhanced retention at both 24-h and 1-week intervals, while CRF at 0.1 microgram impaired retention in the same task at 1 week only. These results confirm that the amygdala is important in memory processing and suggest that the mechanisms involved in the action of CRF on memory retention of aversive and appetitive learnings are different. The possible differences are also discussed.
Lee
E H
EH
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Sung
Y J
YJ
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D001931:Brain Mapping; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D008297:Male; D008568:Memory; D011939:Mental Recall / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D018019:Receptors, Corticotropin-Releasing Hormone; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology*
D018019:Receptors, Corticotropin-Releasing Hormone; D017981:Receptors, Neurotransmitter; D003346:Corticotropin-Releasing Hormone