Effect of canine parvovirus on erythroid progenitors in phenylhydrazine-induced regenerative hemolytic anemia in dogs.
The effects of canine parvovirus (CPV) infection in dogs with hemolytic anemia was compared with the clinical effects of human parvovirus-induced aplastic anemia in human beings with chronic regenerative anemias. Phenylhydrazine was used to induce a transient, severe, hemolytic anemia in dogs to evaluate the effects of CPV infection on rapidly dividing bone marrow precursors. Erythrocyte colony-forming unit bone marrow cultures and cytologic examination of bone marrow were used to determine the effects of CPV infection on erythroid bone marrow precursors. The induced hemolytic anemia regenerated rapidly and although the bone marrow was infected, it was determined that CPV infection did not induce a detectable decrease in erythroid progenitors in dogs with severe hemolytic anemia.
Brock
K V
KV
Department of Pathobiology, University of Tennessee Veterinary Teaching Hospital, Knoxville 37901.
Jones
J B
JB
Shull
R M
RM
Potgieter
L N
LN
D000741:Anemia, Aplastic / Q000382:microbiology / Q000662:veterinary; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D000818:Animals; D001856:Bone Marrow Examination / Q000662:veterinary; D003114:Colony-Forming Units Assay / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004912:Erythrocytes; D006412:Hematopoietic Stem Cells; D006801:Humans; D010321:Parvoviridae / Q000502:physiology; D010322:Parvoviridae Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D010659:Phenylhydrazines / Q000494:pharmacology
D010659:Phenylhydrazines; C030299:phenylhydrazine