[The endogenous opioid system and selective attention].
The effects of fentanyl and naloxone upon the late components (P150 and P300) of auditory evoked potentials were examined with the purpose of establishing its electrophysiological mechanism of action. 50 adult patients were evaluated by means of three pharmacological paradigms: 1. Initial control (C), saline solution (S) and final control (C'). 2. C, fentanyl (F) and C'. 3. C, naloxone (N) and C'. Fentanyl decreased the amplitude of components P150 and P300, as well as patients' performance; while naloxone increased the amplitude of P150 and small P300 (S), having opposite effect upon the large P300 (L). It is concluded that fentanyl caused a global disminution of patients' attention, while naloxone improves attention in patients with P300S and depresses subjects with P300L.
Castañeda-Trujillo
R
R
D000328:Adult; D001288:Attention / Q000187:drug effects*; D004723:Endorphins / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011897:Random Allocation; D011957:Receptors, Opioid / Q000502:physiology
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D005283:Fentanyl
Sistema opioide endógeno y atención selectiva.