Prevention of cardiac arrhythmias by adaptation to hypoxia: regulatory mechanisms and cardiotropic effect.
Adaptation to intermittent hypoxia had a pronounced antiarrhythmic effect in acute myocardial ischemia in conscious animals. This effect was less pronounced in anesthesia and was absent in isolated heart. In reperfusion, the prophylactic effect of adaptation was equally pronounced in all cases. Adaptation prevented stress-induced exhaustion of brain beta-endorphine presumably by its accumulation in adrenal glands and resulted in the accumulation of dopamine, 5-hydroxytryptamine and 5-hydroxyindolacetic acid in brain structures. These data naturally lead to the assumption that central mechanisms play the main role in the antiarrhythmic effect of adaptation to intermittent hypoxia on ischemic arrhythmias, while mechanisms occurring at the level of heart play the main role in the protective effect of the same adaptation against reperfusion arrhythmias.
Meerson
F Z
FZ
Institute of General Pathology and Pathological Physiology of the USSR AMS, Moscow.
Ustinova
E E
EE
Manukhina
E B
EB
D000064:Acclimatization; D000311:Adrenal Glands / Q000378:metabolism*; D000531:Altitude; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D001921:Brain / Q000378:metabolism*; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D015425:Myocardial Reperfusion; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D001615:beta-Endorphin / Q000378:metabolism
D018377:Neurotransmitter Agents; D001615:beta-Endorphin