title: [Medical therapy of peptic ulcer: problems and prospects].
abstract: In the last few years, several drugs have been proposed for the healing of peptic ulcers H2 receptor antagonists are probably the reference-drugs for their efficacy and safety. Acute treatment of peptic ulcer with cimetidine, ranitidine or famotidine gives a high healing rate: from 60% to 90%, depending on the location of the ulcer and the drug used. However, relapse after short-term treatment still remains frequent, and prophylaxis of recurrence must be decided. Long-term treatment with antisecretory drugs could be dangerous for changes of the gastric system, with nitrites and nitro-compounds occurrence, and for the risk of frequent relapses. Therefore, the role of mucus-barrier drugs and surgery must be reconsidered.
authors.forename: E
authors.initials: E
authors.lastname: Trabucchi
authors.forename: D
authors.initials: D
authors.lastname: Foschi
authors.forename: P
authors.initials: P
authors.lastname: Belloli
authors.forename: F
authors.initials: F
authors.lastname: Montorsi
authors.forename: V
authors.initials: V
authors.lastname: Marchetti
authors.forename: C
authors.initials: C
authors.lastname: Mariscotti
authors.forename: S
authors.initials: S
authors.lastname: Diamantini
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D012008:Recurrence
chemical_list: D006635:Histamine H2 Antagonists
vernacular_title: La terapia medica dell'ulcera peptica: problemi e prospettive.