title: Effect of diethyldithiocarbamate on gastric and duodenal mucosal blood flow and vascular permeability in rats.
abstract: Diethyldithiocarbamate (DDC), an inhibitor of superoxide dismutase, produced ulceration in the proximal duodenum of rats, and erosions or ulcers in the stomach. DDC given s. c. at 1.5 g/kg increased duodenal and gastric vascular permeability, and reduced blood flow. The decrease in gastric blood flow caused by DDC was attenuated by pretreatment with superoxide dismutase, and significantly inhibited by a xanthine oxidase inhibitor, allopurinol. It is suggested that the superoxide and other radicals damage the mucosal vasculature, and play a role in the pathogenesis of gastric and duodenal mucosal lesions.
authors.affiliation: Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Teramura
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Saita
authors.forename: J K
authors.initials: JK
authors.lastname: Yoo
authors.forename: S
authors.initials: S
authors.lastname: Kusaka
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: T
authors.initials: T
authors.lastname: Miyake
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced; D004386:Duodenum / Q000098:blood supply*; D005753:Gastric Mucosa / Q000098:blood supply*; D007413:Intestinal Mucosa / Q000098:blood supply*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced; D013997:Time Factors
chemical_list: D004050:Ditiocarb