title: Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.
abstract: Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.
authors.affiliation: Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109.
authors.forename: S R
authors.initials: SR
authors.lastname: Turk
authors.forename: N A
authors.initials: NA
authors.lastname: Kik
authors.forename: G M
authors.initials: GM
authors.lastname: Birch
authors.forename: D J
authors.initials: DJ
authors.lastname: Chiego
authors.forename: C
authors.initials: C
authors.lastname: Shipman
mesh_terms: D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000382:microbiology*; D006651:Histocytochemistry; D009154:Mutation; D012264:Ribonucleotide Reductases / Q000235:genetics*; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics* / Q000502:physiology; D012867:Skin / Q000473:pathology; D014779:Virus Replication
chemical_list: D012264:Ribonucleotide Reductases