title: Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.
abstract: We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28. X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. DXS374--and therefore GABRA3--lies distal to the fragile X locus at a recombination fraction of approximately .15.
authors.affiliation: Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England.
authors.forename: M V
authors.initials: MV
authors.lastname: Bell
authors.forename: J
authors.initials: J
authors.lastname: Bloomfield
authors.forename: M
authors.initials: M
authors.lastname: McKinley
authors.forename: M N
authors.initials: MN
authors.lastname: Patterson
authors.forename: M G
authors.initials: MG
authors.lastname: Darlison
authors.forename: E A
authors.initials: EA
authors.lastname: Barnard
authors.forename: K E
authors.initials: KE
authors.lastname: Davies
mesh_terms: D015342:DNA Probes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D001523:Mental Disorders / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011963:Receptors, GABA-A / Q000235:genetics*; D015183:Restriction Mapping; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D011963:Receptors, GABA-A