title: Effect of lead acetate administration on ATPases of brain and its mitochondrial and synaptosomal fractions in adult mice.
abstract: The effects of oral administration of lead acetate on the activities of cation-transport ATPases and on the brain and its mitochondrial and synaptosomal fractions of male mice were studied at doses of 1, 5, and 20 mg lead acetate per 100 g body weight per day for 4, 8, 12, and 16 weeks. The activities of Na(+)-ATPase, K(+)-ATPase, total-ATPase, and Na(+)-K(+)-ATPase decreased significantly at doses of 1 and 5 mg lead acetate after 12 and 16 weeks of treatment; changes in the activities were not marked after 4 and 8 weeks of lead administration. However, the 20-mg dose significantly reduced enzyme activities at all treatment intervals.
authors.affiliation: Department of Biophysics, Panjab University, Chandigarh, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Bansal
authors.forename: N
authors.initials: N
authors.lastname: Kaushal
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D027682:Cation Transport Proteins; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000201:enzymology*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology*; D013997:Time Factors
chemical_list: D027682:Cation Transport Proteins; D009942:Organometallic Compounds; D000251:Adenosine Triphosphatases; C022761:potassium transporting ATPase; C021838:sodium-translocating ATPase; D000254:Sodium-Potassium-Exchanging ATPase; C008261:lead acetate