Nasal absorption of 17 alpha-ethinyloestradiol in the rat.
The bioavailability of 17 alpha-ethinyloestradiol was determined after intravenous, nasal, and intraduodenal, administration in the rat. The results showed that the bioavailability of nasally-administered and intraduodenally-administered drug was 80-85, and 15-25%, respectively, of that following intravenous administration. The study demonstrates that the nasal route for the administration of 17 alpha-ethinyloestradiol is superior to the oral route in this species, and may thus provide an alternative for the administration of this drug at lower doses.
Bawarshi-Nassar
R N
RN
College of Pharmacy, University of Kentucky, Lexington 40536.
Hussain
A
A
Crooks
P A
PA
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D004386:Duodenum; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004997:Ethinyl Estradiol