[Viral etiology of cancer of the uterine cervix. II. Detection of human cytomegalovirus DNA sequence and antigen in cervical lesions].
Human cytomegalovirus (HCMV) DNA sequence and HCMV antigen were detected by dot blot hybridization and PAP staining in biopsy specimens from cervical lesions. The results showed that the positive rate of HCMV DNA sequence was 73% in cervical cancer and 73% in cervical dysplasia which were higher than that in chronic cervicitis (44%) (P less than 0.05). HCMV antigen could be detected in all kinds of cervical lesions. But there was no significant difference in the positive rates. The detection rate of HCMV DNA sequence was not always in accordance with that of HCMV antigen. The results indicate that HCMV may be another high risk factor of cervical cancer.
Meng
X J
XJ
Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan.
D000956:Antigens, Viral / Q000032:analysis*; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000382:microbiology; D003587:Cytomegalovirus / Q000276:immunology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000209:etiology* / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000382:microbiology
D000956:Antigens, Viral; D004279:DNA, Viral