Action of rimantadine on the structure of influenza A virus haemagglutinin.
Rimantadine prevents the conformational changes of influenza virus haemagglutinin (HA) caused by acid pH and the acquisition of sensitivity to trypsin, protects the haemolytic activity from inactivation and prevents the morphological changes of HA spikes on the virus surface.
Mikheeva
A V
AV
Moscow Research Institute of Viral Preparations, U.S.S.R.
Melnikov AYa
Anisimova
E
E
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002642:Chick Embryo; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D009980:Influenza A virus / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D008561:Membrane Fusion / Q000187:drug effects*; D011487:Protein Conformation / Q000187:drug effects; D012299:Rimantadine / Q000494:pharmacology*; D014357:Trypsin; D014771:Virion / Q000187:drug effects / Q000648:ultrastructure
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D012299:Rimantadine; D014357:Trypsin; D000218:Adamantane