title: Nonporous hydroxylapatite in the repair of alveolar clefts in a primate model: clinical and histologic findings.
abstract: Twelve adult Rhesus monkeys with surgically created alveolar clefts (ACs) underwent repair that used nonporous hydroxylapatite (NPHA) granules on one side and autogenous particulate bone in the contralateral defect. Clinical and radiographic evaluations at 1, 2, 3, 6, and 12 months postoperatively disclosed some displacement of granules initially, but this stabilized by 2 months. Three of 12 sites repaired with NPHA and four of 12 sites repaired with bone dehisced; however, all of these healed by 2 months. No untoward inflammatory or resorptive changes were observed beyond 3 months. The repaired alveolar processes were similar in bulk and contour in sites grafted with NPHA and with bone. Histologically, giant cells were noted at 3 months, but the number decreased at 6 months and remained at that level up to 12 months. The NPHA granules were embedded in mature fibrous connective tissue with osseous ingrowth evident in eight of the 12 defects. It was concluded that NPHA granules are an acceptable implant material for repair of residual alveolar clefts in which erupting teeth and orthodontic movements are not factors.
authors.affiliation: University of Connecticut, School of Dental Medicine, Farmington.
authors.forename: B B
authors.initials: BB
authors.lastname: Horswell
authors.forename: M
authors.initials: M
authors.lastname: el Deeb
mesh_terms: D000539:Alveolar Process / Q000473:pathology / Q000601:surgery*; D000818:Animals; D016025:Bone Transplantation; D017886:Durapatite; D005260:Female; D006882:Hydroxyapatites; D008253:Macaca mulatta; D009957:Oroantral Fistula / Q000601:surgery; D011183:Postoperative Complications / Q000601:surgery*; D019736:Prostheses and Implants
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite