(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.
Clark
R D
RD
Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
Repke
D B
DB
Kilpatrick
A T
AT
Brown
C M
CM
MacKinnon
A C
AC
Clague
R U
RU
Spedding
M
M
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D007546:Isoquinolines; D009287:Naphthyridines; C060956:Delequamine