title: N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum.
abstract: Glutamate receptors appear to play a key role in several forms of experience-dependent modification of both the strength of synapses and synaptic connectivity. In developing Xenopus frogs, the connections made by isthmotectal axons relaying visual input from the eye to the ipsilateral tectum are markedly influenced by the visual activity of contralateral retinotectal axons, and normal binocular visual input is necessary in order for the ipsilateral visuotectal map to come into register with the contralateral map. We have tested whether NMDA receptors play a role in establishment of the topographic matching of binocular maps during development. We have examined the effects of chronic treatment of tectum with either the receptor agonist NMDA or the antagonists APV or CPP applied throughout early postmetamorphic life using subpial implants of drug-impregnated elvax. Both antagonists blocked the matching of the ipsilateral map to the contralateral map, while NMDA permitted such matching. Our data therefore indicate that NMDA receptors are involved in the experience-dependent establishment of matching binocular maps during development.
authors.affiliation: Department of Physiology, State University of New York, Buffalo 14214.
authors.forename: W J
authors.initials: WJ
authors.lastname: Scherer
authors.forename: S B
authors.initials: SB
authors.lastname: Udin
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001224:Aspartic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007839:Functional Laterality; D016202:N-Methylaspartate; D010879:Piperazines / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*; D014794:Visual Fields / Q000187:drug effects*; D014981:Xenopus
chemical_list: D000927:Anticonvulsants; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid