Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors.
In vitro, Type I receptors have high and equivalent affinity for aldosterone, corticosterone and cortisol: in vivo, physiological mineralocorticoid target tissues (kidney, colon, parotid) are highly aldosterone-selective, in contrast with hippocampus and heart. In the present study we show that the mesenteric vascular arcade is similarly highly aldosterone-selective in vivo, and in vitro shows considerable levels of 11 beta OH steroid dehydrogenase activity, previously postulated as the mechanism whereby glucocorticoids are excluded from physiological mineralocorticoid receptors.
Funder
J W
JW
Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia.
Pearce
P T
PT
Smith
R
R
Campbell
J
J
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001808:Blood Vessels / Q000201:enzymology / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008297:Male; D008901:Mineralocorticoids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000378:metabolism*; D013152:Splanchnic Circulation
D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D000450:Aldosterone; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases