Studies on rotavirus homologous and heterologous active immunity in infant mice.
Homologous and heterologous active immunity was studied in mice with mammalian group A rotaviruses. One day old mice were vaccinated with one of the following rotaviruses: bovine B641 (serotype 6), bovine B223 (untyped), simian SA11 (serotype 3) and murine EDIM (untyped). At 10 days of age they were challenged with EDIM virulent virus or SA11 virus. All the vaccines induced a serological antibody response in the mice but only the homologous immune response was protective.
Woode
G N
GN
Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Texas A&M University, College Station.
Zheng
S
S
Melendy
D R
DR
Ramig
R F
RF
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002478:Cells, Cultured; D003967:Diarrhea / Q000382:microbiology; D051379:Mice; D012401:Rotavirus / Q000145:classification / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control; D012703:Serotyping; D013045:Species Specificity; D014611:Vaccination