title: Oxygen radicals in CNS damage.
abstract: The products of univalent reduction of oxygen, superoxide anion radical, hydrogen peroxide, and the hydroxyl radical, are capable of causing cellular damage and death. They are, therefore, logical candidates as mediators of vascular and parenchymal injury in the central nervous system (CNS). This paper reviews the sources of oxygen radicals in the CNS, their effects on cerebral vessels and on brain and spinal cord parenchyma, and the evidence which implicates oxygen radicals in various pathological conditions of the CNS.
authors.affiliation: Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0281.
authors.forename: H A
authors.initials: HA
authors.lastname: Kontos
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000209:etiology; D002490:Central Nervous System / Q000187:drug effects / Q000473:pathology*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide; D006878:Hydroxides; D017665:Hydroxyl Radical; D010100:Oxygen / Q000633:toxicity*; D013481:Superoxides
chemical_list: D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D010100:Oxygen