Induction by sodium butyrate of cytomegalovirus replication in human endothelial cells.
Cultured endothelial cells are shown to be induced in regard to permissiveness to human cytomegalovirus by temporary treatment postinfection with sodium butyrate (1-2 mM). Drug-treated cells are demonstrated to exhibit expression of immediate early and early viral antigens, synthesis of viral DNA and viral structural glycoprotein B. Progeny virus could be visualized by electron microscopy.
Radsak
K
K
Institute of Virology, Philipps University, Marburg, Federal Republic of Germany.
Fuhrmann
R
R
Franke
R P
RP
Schneider
D
D
Kollert
A
A
Brücher
K H
KH
Drenckhahn
D
D
D000956:Antigens, Viral / Q000096:biosynthesis; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D004279:DNA, Viral / Q000096:biosynthesis / Q000187:drug effects; D004727:Endothelium; D006801:Humans; D017874:Immediate-Early Proteins; D014759:Viral Envelope Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D000956:Antigens, Viral; D002087:Butyrates; D004279:DNA, Viral; D017874:Immediate-Early Proteins; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus; C044582:immediate-early proteins, cytomegalovirus; D020148:Butyric Acid