Successful salvage therapy of resistant gestational trophoblastic disease with etoposide, methotrexate, dactinomycin, vincristine, and cyclophosphamide.
A case of poor prognosis metastatic trophoblastic disease resistant to chemotherapy with methotrexate, dactinomycin, and cyclophosphamide is presented. The patient responded promptly to etoposide-based combination chemotherapy and has remained in complete remission since completion of therapy.
Gallion
H H
HH
Division of Gynecologic Oncology, University of Kentucky Medical Center, Lexington 40536.
van Nagell
J R
JR
Donaldson
E S
ES
Higgins
R V
RV
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use
D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate