title: Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord.
abstract: The present study combined the retrograde transport of fluorescent tracers with the immunocytochemical identification of dynorphin A(1-8) in superficial dorsal horn neurons to examine whether peripheral inflammation-induced dynorphin increases are found in local circuit neurons only or also in neurons projecting at least to the caudal mesencephalon. Evidence is presented that complete Freund's adjuvant-induced inflammation produces a large increase in the number of lamina I dynorphin-containing projection and non-projection neurons, and in the number of lamina II dynorphin local circuit neurons.
authors.affiliation: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, Bethesda, MD 20892.
authors.forename: R L
authors.initials: RL
authors.lastname: Nahin
authors.forename: J L
authors.initials: JL
authors.lastname: Hylden
authors.forename: M J
authors.initials: MJ
authors.lastname: Iadarola
authors.forename: R
authors.initials: R
authors.lastname: Dubner
mesh_terms: D000818:Animals; D002452:Cell Count; D004399:Dynorphins / Q000378:metabolism*; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
chemical_list: D005456:Fluorescent Dyes; D010446:Peptide Fragments; D004399:Dynorphins; C026770:dynorphin (1-8)