title: Modulation of immune suppression and enhanced tumorigenesis in retrovirus tumor challenged chickens treated with vitamin E.
abstract: Vitamin E(dl-alpha-tocopherol) dissolved in ethanol with polyethylene glycol as the vehicle and administered by intraperitoneal injections of 0.1 mg/gm body weight at two day intervals, was demonstrated to be a potent immunomodulating reagent in young chickens challenged with avian reticuloendotheliosis virus-transformed tumor cells. Vitamin E treatment enhanced the mitogen-induced proliferative responses of spleen cells from age matched, unchallenged chickens; reduced the tumor cell-induced suppression of host splenic lymphocyte mitogen responses; and eliminated tumor cell-induced suppressor cell activity. However, inspite of an improved immune status the vitamin E treated-tumor cell challenged chickens exhibited enhanced tumorigenesis.
authors.affiliation: Division of Nutrition, University of Texas, Austin 78712.
authors.forename: K
authors.initials: K
authors.lastname: Kline
authors.forename: B G
authors.initials: BG
authors.lastname: Sanders
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D001356:Reticuloendotheliosis virus / Q000235:genetics*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D007166:Immunosuppressive Agents; D008934:Mitogens; D014810:Vitamin E