Tyrosine hydroxylase and levodopa responsive dystonia.
It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.
Fletcher
N A
NA
Department of Clinical Neurology, Institute of Neurology, London, UK.
Holt
I J
IJ
Harding
A E
AE
Nygaard
T G
TG
Mallet
J
J
Marsden
C D
CD
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D004421:Dystonia / Q000188:drug therapy / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D015342:DNA Probes; D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase