Prolonged IgM antibodies and histopathological evidence of chronicity in hepatitis A.
The case of a young man with hepatitis A and a chronic course is presented. The patient received a short course of steroid therapy for recurrence of symptoms following acute hepatitis A. Thereafter, liver enzymes have remained marginally elevated for 4 years and annual liver biopsies have shown evidence of chronicity. HAV IgM Ab persisted for 1034 days with subsequent development of HAV IgG Ab. The possibility of other viruses in the aetiology and the role of steroids in the development of chronicity are discussed.
McDonald
G S
GS
Department of Histopathology, Trinity College, Dublin, Ireland.
Courtney
M G
MG
Shattock
A G
AG
Weir
D G
DG
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D001706:Biopsy; D002908:Chronic Disease; D006506:Hepatitis A / Q000276:immunology / Q000473:pathology*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D008107:Liver Diseases / Q000276:immunology / Q000473:pathology; D008297:Male; D013997:Time Factors
D000914:Antibodies, Viral; D007075:Immunoglobulin M