Slip and leak in mitochondrial oxidative phosphorylation.
During oxidative phosphorylation by mammalian mitochondria part of the free energy stored in reduced substrates is dissipated and energy is released as heat. Here I review the mechanisms and the physiological significance of this phenomenon.
Murphy
M P
MP
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
D000255:Adenosine Triphosphate / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D002463:Cell Membrane Permeability; D004553:Electric Conductivity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D011522:Protons
D011522:Protons; D000255:Adenosine Triphosphate