title: Caffeine withdrawal affects central adenosine receptors but not benzodiazepine receptors.
abstract: The effects of chronic caffeine administration on both adenosine and benzodiazepine receptors were studied in mouse brain membranes. Animals were fed on a diet enriched with caffeine (600 mg/kg diet) for 15 days and sacrificed 2, 4, 8 and 15 days after withdrawal. Compared with controls fed on a regular diet, animals receiving a caffeine-enriched diet showed an increase in the number of brain adenosine receptors labeled with [3H]-DPX in both the cerebellum and forebrain regions. This up-regulation was still significant 15 days after withdrawal in the cerebellum but not in the forebrain, where the number of adenosine receptors returned to control levels within 8 days following withdrawal. Benzodiazepine receptors labeled by [3H]-B-CCE were not influenced by chronic caffeine diet or withdrawal.
authors.affiliation: Centre Psychiatrique Esquirol, INSERM U 320, Université de Caen, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Boulenger
authors.forename: P J
authors.initials: PJ
authors.lastname: Marangos
mesh_terms: D000818:Animals; D002110:Caffeine / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011963:Receptors, GABA-A / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects*
chemical_list: D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D002110:Caffeine