Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.
Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.
Ram
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Department of Radiology, Duke University Medical Center, Durham, NC 27701.
Spicer
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LD
D002245:Carbon Dioxide; D002250:Carbon Radioisotopes; D002746:Chlorpromazine / Q000138:chemical synthesis*; D006801:Humans; D007553:Isotope Labeling
D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D002746:Chlorpromazine