[Dopamine deficiency syndrome in children with specific reaction to the treatment with levodopa preparations].
The authors describe the dopamine deficiency syndrome in children with the disease beginning during their first year and peculiar dystonia++ symptoms resulting in a total immobilization and speech loss. All the symptoms of the disease can be removed by low doses of Nakom and reappeared upon the drug withdrawal. Tyrosine hydroxylase studies performed in these patients at various stages of the disease showed an unusual pattern of the enzyme activity differing from that seen in children with similar pathology failing to improve dramatically under the Nakom treatment.
Shoshina
L M
LM
Grinio
L P
LP
Mineeva
M F
MF
D000293:Adolescent; D001037:Aphasia / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D002230:Carbidopa / Q000008:administration & dosage*; D002648:Child; D004298:Dopamine / Q000172:deficiency*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000008:administration & dosage; D004422:Dystonia Musculorum Deformans / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase; D002230:Carbidopa; D004298:Dopamine
Sindrom dofaminovoĭ nedostatochnosti u deteĭ s osoboĭ reaktsieĭ na lechenie preparatami levodopy.