FN-C1q and C1 INH C1r-C1s complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia.
We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL.
Hidvégi
T
T
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Ermolin
G A
GA
Efremov
E E
EE
Dikov
M M
MM
Kurmanova
L V
LV
Vnashenkova
G V
GV
Merkulova
M V
MV
Kókai
M
M
Panya
A
A
Füst
G
G
D000936:Antigen-Antibody Complex; D002352:Carrier Proteins; D003166:Complement Activating Enzymes / Q000276:immunology*; D003167:Complement Activation; D003172:Complement C1 / Q000276:immunology*; D003174:Complement C1 Inactivator Proteins / Q000276:immunology*; D015922:Complement C1q; D015923:Complement C1r; D004797:Enzyme-Linked Immunosorbent Assay; D005353:Fibronectins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011951:Receptors, Complement / Q000276:immunology*
D000936:Antigen-Antibody Complex; C087299:C1QBP protein, human; D002352:Carrier Proteins; D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D005353:Fibronectins; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011951:Receptors, Complement; C032402:complement 1q receptor; D015922:Complement C1q; D003166:Complement Activating Enzymes; D015923:Complement C1r