Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.
The DMD gene, which spans more than 2,000 kbp, has been assigned to band Xp21 of the X chromosome. Two subclones (PERT 87-1 and PERT 87-15) of the intragenic locus DXS164 physically are separated by approximately 60 kbp. Linkage studies were done in 49 informative DMD families by using the LINKAGE program. Crossing-over between the loci studied occurred in four families. A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 (support interval 14-135-fold) times higher than expected, was found with a maximum lod score of 13.50. These data suggest a hot spot for recombination within DXS164.
Grimm
T
T
Institut für Humangenetik, Universität Würzburg, Federal Republic of Germany.
Müller
B
B
Dreier
M
M
Kind
E
E
Bettecken
T
T
Meng
G
G
Müller
C R
CR
D000483:Alleles; D002874:Chromosome Mapping; D015342:DNA Probes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers