Hyperosmolality due to antacid treatment.
Magnesium trisilicate mixture is an antacid used commonly in our Intensive Care Unit in the prevention and treatment of stress ulcers. In this case the administration of large doses over a period of time led to the development of massive hyperosmolality, cerebral dehydration and coma. Management with hypotonic fluid resulted in complete recovery.
Faraj
J H
JH
Anesthesiology Department, Ibn Sina Hospital, Kuwait.
D000863:Antacids / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D005440:Fluid Therapy; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D008274:Magnesium / Q000009:adverse effects*; D017633:Magnesium Silicates; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012824:Silicic Acid / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000009:adverse effects*; D012964:Sodium / Q000097:blood
D000863:Antacids; D017633:Magnesium Silicates; D012824:Silicic Acid; D012822:Silicon Dioxide; D012964:Sodium; C001671:magnesium trisilicate; D008274:Magnesium