Calcium and sodium transport in gestational hypertension.
The enzymatic activities of Na+/K+ ATPase and Ca2+ ATPase were determined on erythrocyte membranes from 9 normotensive and 9 gestational hypertensive pregnant women near term. A reduction in the activity of the Na+/K+ ATPase and a relative increase in the activity of the Ca2+ ATPase were found in the hypertensive patients, possibly due to a conformational alteration of erythrocyte membranes. This observation supports the possible role of the transmembrane cation transport in the pathogenesis of gestational hypertension.
Tranquilli
A L
AL
Department of Obstetrics and Gynecology, University of Ancona, Italy.
Rabini
R A
RA
Cugini
A M
AM
Cester
N
N
Valensise
H
H
Romanini
C
C
Bertoli
E
E
Mazzanti
L
L
D000328:Adult; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000378:metabolism*; D007700:Kinetics; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology / Q000378:metabolism*; D011507:Proteinuria / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D012964:Sodium; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium