Amoxycillin plus tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels.
32 children (mean age 12 years, range 6-18) with non-specific abdominal pain and Campylobacter pylori positive gastritis received a six week course of daily oral amoxycillin (50 mg/kg) and tinidazole (20 mg/kg). Before treatment and one month after stopping treatment, endoscopic biopsy samples were taken from the antral mucosa and serum C pylori IgG antibody, pepsinogen I, and gastrin levels were measured in fasting blood samples. One month after treatment 30 children (94%) were cleared of C pylori and gastritis had resolved in 27 (84%) and was improved in the remaining 5. Serum IgG, pepsinogen I, and gastrin levels were significantly decreased after treatment. Of 12 children assessed at six months, 9 remained free of C pylori. Increases or decreases in IgG level indicated clearance or recurrence, respectively, of C pylori.
Oderda
G
G
Paediatric Gastroenterology Section, University of Turin, Italy.
Vaira
D
D
Holton
J
J
Ainley
C
C
Altare
F
F
Ansaldi
N
N
D000284:Administration, Oral; D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000032:analysis*; D002167:Campylobacter / Q000276:immunology / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D002648:Child; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010435:Pepsinogens / Q000097:blood*; D011706:Pyloric Antrum / Q000382:microbiology; D012008:Recurrence; D014011:Tinidazole / Q000008:administration & dosage / Q000627:therapeutic use*
D000907:Antibodies, Bacterial; D005755:Gastrins; D007074:Immunoglobulin G; D009593:Nitroimidazoles; D010435:Pepsinogens; D014011:Tinidazole; D000658:Amoxicillin