Anti-idiotypic B-cell lines from a patient with monoclonal gammopathy of undetermined significance.
The B-cell repertoire in a patient with benign monoclonal gammopathy of unknown significance was studied using Epstein-Barr virus transformation of peripheral lymphocytes. The presence of anti-idiotypic B cells producing monoclonal antibodies that reacted with idiotypic determinants on the monoclonal immunoglobulin was verified. The two monoclonal anti-idiotypic antibodies studied were of the IgM-kappa type. Such anti-idiotypic antibodies may be part of an idiotypic network regulation of the monoclonal B-cell population.
Andersson
M
M
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Holm
G
G
Lefvert
A K
AK
Mellstedt
H
H
D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology; D008875:Middle Aged; D010265:Paraproteinemias / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M