Renal effects of vanadate in rats of different ages.
Both in conscious and in anesthetized rats the degree of increase in renal excretion of sodium following vanadate administration is nearly the same in adult and young rats. Remarkably, in anesthetized rats i.v. administered vanadate (0.2 mg/100 g b.m.) acts distinctly longer in 20-day-old rats compared with adults. Likely, age dependent differences in inactivation of vanadate exist. The degree of inhibition of Na+/K(+)-ATPase by vanadate is lower in young than in adult rats. Vanadate has no distinct effect on renal tubular transport of p-aminohippurate in rats of different ages.
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, DDR.
Pfeifer
R
R
Grau
P
P
Reznik
L
L
D000375:Aging; D000818:Animals; D004231:Diuresis; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014638:Vanadates / Q000008:administration & dosage / Q000494:pharmacology*; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D014638:Vanadates; D000254:Sodium-Potassium-Exchanging ATPase; D010130:p-Aminohippuric Acid