The effect of acutely administered phenytoin on vecuronium-induced neuromuscular blockade.
Phenytoin was administered intravenously in a dose of 10 mg kg to a group of patients in whom steady state neuromuscular blockade had been established with an infusion of vecuronium. A control group of patients were given 0.9% saline instead of phenytoin. Administration of phenytoin produced significant augmentation of neuromuscular blockade (p less than 0.001). The possible mechanism of this effect is discussed.
Gray
H S
HS
Department of Anaesthetics, Manchester Royal Infirmary.
Slater
R M
RM
Pollard
B J
BJ
D000328:Adult; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D010672:Phenytoin / Q000008:administration & dosage*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage
D010672:Phenytoin; D014673:Vecuronium Bromide