title: Localization of cyclic adenosine monophosphate in the teleost retina: effects of dopamine and prolonged darkness.
abstract: Localization of cyclic adenosine monophosphate (cAMP) in the white perch retina was carried out with immunohistochemical and autoradiographic methods. Following exposure to dopamine or prolonged darkness, cAMP staining was observed by immunohistochemistry in the distal part of the inner nuclear layer, i.e. in the horizontal cells. After exposure to dopamine, increased levels of cAMP were also observed by autoradiography in many horizontal cells. Finally, increased levels of cAMP staining were observed immunohistochemically following incubation with dopamine in all types of cone-related horizontal cells that had been isolated and maintained in culture.
authors.affiliation: Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
authors.forename: L H
authors.initials: LH
authors.lastname: Young
authors.forename: J E
authors.initials: JE
authors.lastname: Dowling
mesh_terms: D000818:Animals; D001345:Autoradiography; D000242:Cyclic AMP / Q000378:metabolism* / Q000502:physiology; D003624:Darkness; D004298:Dopamine / Q000494:pharmacology*; D007150:Immunohistochemistry; D010471:Perches / Q000378:metabolism*; D010473:Perciformes / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism* / Q000502:physiology
chemical_list: D000242:Cyclic AMP; D004298:Dopamine