title: A biochemical correlate of the critical period for synaptic modification in the visual cortex.
abstract: Stimulation of phosphoinositide hydrolysis by excitatory amino acids was studied in synaptoneurosomes of kitten striate cortex at several postnatal ages. Ibotenate and glutamate stimulated phosphoinositide turnover during the second and third postnatal months; N-methyl-D-aspartate and DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) were without effect. The developmental profile of ibotenate-stimulated phosphoinositide turnover parallels the postnatal changes in cortical susceptibility to visual deprivation. The transient increase in ibotenate-stimulated phosphoinositide turnover does not occur in visual cortex of kittens reared in complete darkness.
authors.affiliation: Center for Neural Science, Brown University, Providence, RI 02912.
authors.forename: S M
authors.initials: SM
authors.lastname: Dudek
authors.forename: M F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000375:Aging; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002417:Cattle; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007051:Ibotenic Acid / Q000494:pharmacology; D016202:N-Methylaspartate; D009799:Ocular Physiological Phenomena; D010716:Phosphatidylinositols / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D014785:Vision, Ocular; D014793:Visual Cortex / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology
chemical_list: D005971:Glutamates; D010716:Phosphatidylinositols; D007051:Ibotenic Acid; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D002217:Carbachol