The relationship between Alzheimer's disease, Parkinson's disease and motor neuron disease.
We argue against the dominant status assigned to conventional microscopy in the categorization of disorders such as Alzheimer's disease, Parkinson's disease and ALS. As an example we criticize the emphasis that has been placed on correlating the presence of Lewy bodies with the diagnosis of Parkinson's disease. In essence, we submit that Parkinson's disease can exist without Lewy bodies, and Lewy bodies can exist without Parkinson's disease. Nevertheless, we consider that the newer techniques available to histology have led to an important concept that constitutes a shared feature for Alzheimer's disease. Parkinson's disease and ALS; they are all characterized by the deposition of cytoskeletal debris in tissue, so they may perhaps be collectively termed the "Cytoskeletal Disorders".
Calne
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DB
Belzberg Laboratory of Clinical Neuroscience, Department of Medicine, University Hospital, Vancouver, British Columbia, Canada.
Eisen
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A
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000473:pathology; D010302:Parkinson Disease, Secondary / Q000175:diagnosis* / Q000473:pathology