Trans activation by the bovine papillomavirus E2 protein in Saccharomyces cerevisiae.
The papillomavirus E2 protein functions as an enhancer-binding factor to promote transcription in mammalian cells. We found that one copy of the E2 binding site acted as an E2 protein-dependent upstream activating sequence in Saccharomyces cerevisiae. Additional copies of the binding motif further augmented transcription. These results imply that the E2 protein functionally interacts with highly conserved transcriptional elements.
Morrissey
L C
LC
Department of Dermatology, New England Medical Center, Boston, Massachusetts.
Barsoum
J
J
Androphy
E J
EJ
D052688:Bovine papillomavirus 1 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D009856:Oncogene Proteins, Viral / Q000494:pharmacology*; D027383:Papillomaviridae / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014157:Transcription Factors / Q000494:pharmacology*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D009856:Oncogene Proteins, Viral; D014157:Transcription Factors