title: Brain pH effects of NaHCO3 and Carbicarb in lactic acidosis.
abstract: The effects of iv sodium bicarbonate (NaHCO3) and Carbicarb, an experimental buffer, were compared in a rat model of lactic acidosis induced by controlled hemorrhage and asphyxia. Although both NaHCO3 and Carbicarb were effective at alkalinizing the arterial blood in this model, NaHCO3 administration resulted in a rise in PaCO2 where Carbicarb did not (+9 +/- 2 vs. +2 +/- 2 torr at 2 min after infusion, p less than .01). Moreover, NaHCO3 resulted in a small decrease in intracellular brain pH as measured with P-31 nuclear magnetic resonance where Carbicarb afforded intracellular brain alkalinization (-0.03 +/- 0.01 vs. +0.08 +/- 0.02 pH units at 2 min, p less than .01). If these data are confirmed clinically, Carbicarb may offer advantages over NaHCO3 under conditions of fixed or limited ventilation.
authors.affiliation: Webb-Waring Lung Institute, Denver, CO.
authors.forename: R R
authors.initials: RR
authors.lastname: Kucera
authors.forename: J I
authors.initials: JI
authors.lastname: Shapiro
authors.forename: M A
authors.initials: MA
authors.lastname: Whalen
authors.forename: N B
authors.initials: NB
authors.lastname: Kindig
authors.forename: G F
authors.initials: GF
authors.lastname: Filley
authors.forename: L
authors.initials: L
authors.lastname: Chan
mesh_terms: D000140:Acidosis, Lactic / Q000188:drug therapy*; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002254:Carbonates / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010313:Partial Pressure; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D002254:Carbonates; D004338:Drug Combinations; C046283:sodium bicarbonate, sodium carbonate drug combination; D002245:Carbon Dioxide; D017693:Sodium Bicarbonate; D012964:Sodium