[Formation of p-tyramine from dopamine bound to synaptic receptors of the rat brain in vitro].
Tyramine (TA) revealed earlier during the functioning of dopamine (DA)-receptors of the rat brain (after learning) in vivo was produced from dopamine bound by DA-receptors of the synaptic membranes in the system which was exposed to the influence of the microdischarge electroradialysis in vitro. It is shown that the formation of p-TA under these conditions depends on the period of the micro-discharge effect on the system, it is maximal at exposition of 30 s for I = 4.2 mA. In control solutions of standard DA and DA preincubated with the membranes of the cerebellum homogenate, without DA-receptors, p-TA was not revealed under these conditions. The results obtained confirm the supposition that p-TA is the product of the DA-receptors functioning in vivo.
Podgornaia
E K
EK
Galkina
O V
OV
Poliakov
O V
OV
D000818:Animals; D001362:Avoidance Learning; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000378:metabolism* / Q000502:physiology; D014439:Tyramine / Q000096:biosynthesis* / Q000502:physiology
D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D004298:Dopamine; D014439:Tyramine
Obrazovanie p-tiramina iz dopamina, sviazannogo retseptorami sinapticheskikh membran mozga krys in vitro.