[Physiologic role of the sodium pump. Implications for the study of arterial hypertension].
Mammalian cells have the same hydroelectrolytic composition (high K, low Na), highly different from that of their surrounding. Constancy of cellular composition is insured by the balance between ionic leaks and (Na, K)-pump activity. Ionic leaks, specially sodium, are fundamental. They allow cells to perform a majority of their general and special functions (import of aminoacids, glucose, phosphates; export of acids; nerve influx; muscular contraction; glandular secretion; intestinal and renal reabsorption and secretion). (Na, K)-pump is essential to life. It is a kind of general motor that creates and maintains ionic concentrations differences whose potential energy is dissipated by leaks to perform cellular functions. Constancy of hydroelectrolytic intracellular composition hides that leak and pump rates, equivalent between them, are extremely variable among cell types (more than 200 times), and can increase 4 times in less than one minute within a cell type with cellular activity. In a cell, (Na, K)-pump rate is far from maximum velocity. This rate is adjusted nearly instantaneously to balance variations in leak rates; it may undergo short term modulation by endo or exocellular factors; it may undergo long term changes through synthesis of new enzyme molecules. Studies on whole cells of the balance between leaks and pump rates is necessary to understand these cells physiology and pathology. Balance between leaks and (Na, K)-pump activity is altered in renal cells from hypertensive rats, spontaneously (SHR) or genetically selected (Milan Hypertensive Strain: MHS). Strikingly, sodium activation of (Na, K)-pump of inner medullary collecting duct cells of MHS rats is greatly blunted compared to controls.
Lechene
C
C
Harvard Medical School, Boston, Massachusetts.
Crabos
M
M
Bianchi
G
G
Cantiello
H
H
D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008564:Membrane Potentials; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D015222:Sodium Channels / Q000502:physiology*
D015222:Sodium Channels; D000251:Adenosine Triphosphatases
Rôle physiologique de la pompe à sodium. Implications pour l'étude de l'hypertension artérielle.