Radiosensitization of E. coli B/r by arylhydrazonopropanedinitriles.
Several arylhydrazonopropanedinitriles and an arylhydrazonopropane-diethyl ester (derivatives of well-known uncouplers of oxidative phosphorylation) have been studied with respect to their ability to radiosensitize E. coli B/r under oxic and hypoxic conditions. Of the compounds studied, 2-carboxyphenylhydrazono-propanedinitrile and 2-carboxyphenylhydrazonopropanediethylester were found to be the most efficient radiosensitizers under hypoxia, whilst the former compound was also found to provide radiosensitization under oxic conditions. Increased radiosensitization by 4-carboxyphenylhydrazonopropanedinitrile was observed on decreasing the pH of the irradiation incubation medium. The results are discussed with respect to the physicochemical properties of these compounds and their reactivity with thiols, for which data are presented.
Crump
P W
PW
Department of Biological Sciences, University of Salford, U.K.
Bisby
R H
RH
Cundall
R B
RB
Thomas
E W
EW
D000111:Acetylcysteine; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000528:radiation effects*; D005720:Gamma Rays; D006835:Hydrazones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D009570:Nitriles / Q000494:pharmacology*; D011836:Radiation Tolerance
D006835:Hydrazones; D009570:Nitriles; D000111:Acetylcysteine