title: Platelet-derived-growth-factor-stimulated heterogeneous polyphosphoinositide metabolism and phosphate uptake in C3H fibroblasts.
abstract: Pig platelet-derived growth factor (PDGF) increased the rate of [32P]Pi uptake by murine fibroblasts, resulting in a 3-9-fold elevation of the specific radioactivity of ATP, PtdInsP, PtdInsP2, PtdIns and phosphatidic acid. The specific radioactivity was 10-60-fold higher in ATP than in the four phospholipids. These substances are therefore not in metabolic equilibrium, which complicates determination of inositol phospholipid turnover.
authors.affiliation: Department of Biochemistry, University of Bergen, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Holmsen
authors.forename: R
authors.initials: R
authors.lastname: Male
authors.forename: S
authors.initials: S
authors.lastname: Rongved
authors.forename: N
authors.initials: N
authors.lastname: Langeland
authors.forename: J
authors.initials: J
authors.lastname: Lillehaug
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010710:Phosphates / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*
chemical_list: D010710:Phosphates; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010982:Platelet-Derived Growth Factor; D000255:Adenosine Triphosphate