title: [Biotransformation of B 24/76 in the rat, minipig, dog and man].
abstract: After oral administration of B 24/76 (1) on experimental animals (rat, minipig, dog) and human beings 11 metabolites could be isolated from urine, faeces and bile. The structure of 7 compounds was elucidated by means of TLC and MS. The investigated species are showing an analogues metabolic pattern with differences in the intensity and main metabolites. In phase II-reaction we could observe qualitative differences.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Ernst-Moritz-Arndt-Universität Griefswald.
authors.forename: A
authors.initials: A
authors.lastname: Baumann
authors.forename: R
authors.initials: R
authors.lastname: Seefeld
authors.forename: I
authors.initials: I
authors.lastname: Werner
authors.forename: B
authors.initials: B
authors.lastname: Seifert
authors.forename: M
authors.initials: M
authors.lastname: Witte
authors.forename: S
authors.initials: S
authors.lastname: Pollex
authors.forename: A
authors.initials: A
authors.lastname: Grisk
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000818:Animals; D001711:Biotransformation; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013552:Swine; D013556:Swine, Miniature
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C058041:B 24-76
vernacular_title: Biotransformation von B 24/76 an Ratte, Minischwein, Hund und Mensch.