Circulating prorenin and renin in response to intravenous adrenocorticotrophic hormone in essential hypertension.
Plasma prorenin and renin changes after a bolus injection of 25 U intravenous adrenocorticotrophic hormone (ACTH, synacthen) were studied in seven untreated uncomplicated essential hypertensives over a period of 24 h. Plasma prorenin did not change significantly during the study, whereas renin after 24 h was higher than at baseline (4.3 +/- 0.6 versus 2.3 +/- 0.9 ng angiotensin I (Ang I)/ml per h, P less than 0.01). We conclude that endogenous glucocorticoid stimulation induced by exogenous ACTH and ACTH itself seem to induce a secondary or tertiary rather than a primary effect on the human renin gene.
Troffa
C
C
Centro Ipertensione, Università di Sassari, Italy.
Tonolo
G
G
Soro
A
A
Manunta
P
P
Melis
M G
MG
Pazzola
A
A
Pala
F
F
Madeddu
P
P
Alagna
S
S
Masala
A
A
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000328:Adult; D004792:Enzyme Precursors / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D013997:Time Factors
D004792:Enzyme Precursors; D000324:Adrenocorticotropic Hormone; D012083:Renin; D006854:Hydrocortisone