Long-term effect of antidepressant drugs and electroconvulsive shock (ECS) on cortical alpha 1-adrenoceptors following destruction of dopaminergic nerve terminals.
The effect of repeated treatment with imipramine, citalopram and ECS on the density of alpha 1-adrenoceptors in the cerebral cortex of rats with a dopaminergic lesion was studied. Imipramine and citalopram produced alph 1-upregulation in normal animals but not in animals with a dopaminergic lesion. On the other hand, ECS, produced such an effect in both normal and lesioned rats. Our results indicate that the investigated drugs (imipramine, citalopram) and ECS induce alpha 1-up-regulation via different mechanisms, and that the effect of these drugs depends on intact dopaminergic nerve terminals.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D015283:Citalopram / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004597:Electroshock; D006892:Hydroxydopamines / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism
D000928:Antidepressive Agents; D006892:Hydroxydopamines; D011942:Receptors, Adrenergic, alpha; D015283:Citalopram; D012701:Serotonin; D016627:Oxidopamine; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine