Prevention of experimental calcinosis by salmon calcitonin in rats.
The effects of salmon calcitonin on calcium overload and its deposition in the rat aorta was studied. Calcitonin administered 4 days to rats i.p. in doses of 10 IU/kg body weight blocked the development of calcinosis induced by a single dose of vitamin D3 (300,000 IU/kg body weight, orally). This was demonstrated biochemically, histochemically and by electron microscopic methods.
Czirfusz
A
A
Department of Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Czechoslovakia.
Kovalcík
V
V
Galbavý
S
S
Drábková
E
E
D000818:Animals; D001011:Aorta / Q000473:pathology; D001018:Aortic Diseases / Q000517:prevention & control*; D002114:Calcinosis / Q000517:prevention & control*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D002762:Cholecalciferol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002762:Cholecalciferol; C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium