title: Difference in thiamine metabolism between extensor digitorum longus and soleus muscles.
abstract: 1. Thiamine diphosphate level was higher in soleus muscle than in extensor digitorum longus muscle in various animals, whereas thiamine triphosphate level was less in the former muscle than in the latter except for mouse. 2. 2-Oxoglutarate dehydrogenase, transketolase and thiamine pyrophosphokinase activities were higher in soleus muscle than in extensor digitorum longus in rat and guinea pig. 3. The differences between rat two muscle phenotypes in thiamine diphosphate, but not thiamine triphosphate, level and the thiamine-related enzyme activities disappeared after denervation. 4. Tenotomy had little effect on thiamine phosphate levels and the thiamine-related enzyme activities in rat skeletal muscles.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Tonomura
authors.forename: A
authors.initials: A
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Iwata
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008297:Male; D051379:Mice; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism*; D010641:Phenotype; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013836:Thiamin Pyrophosphokinase / Q000378:metabolism; D013831:Thiamine / Q000378:metabolism*; D013835:Thiamine Pyrophosphate / Q000032:analysis; D013838:Thiamine Triphosphate / Q000032:analysis; D013997:Time Factors; D014174:Transketolase / Q000378:metabolism
chemical_list: D013838:Thiamine Triphosphate; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase; D013836:Thiamin Pyrophosphokinase; D013835:Thiamine Pyrophosphate; D013831:Thiamine