Effect of epidermal growth factor on non-steroidal anti-inflammatory drug-induced intestinal damage.
Epidermal growth factor (EGF, 10 micrograms/kg po, ip, or sc, BID, and 20 micrograms/kg iv) had no protective activity in the indomethacin-induced intestinal lesion model (6 h model). In the ethanol-induced gastric lesion model, EGF (10 micrograms/kg sc) reduced lesions by 52% and reduced gastric acid secretion by 68% (5 micrograms/kg iv). In the 24 h indomethacin-induced intestinal lesion model, pretreatment with EGF (10 micrograms/kg sc, BID; 1 day before and during indomethacin treatment) had no beneficial effects. Therefore, EGF had no protective effects against non-steroidal antiinflammatory drug (NSAID)-induced intestinal lesions at doses that protect against the necrotizing action of ethanol and that inhibit gastric acid secretion in the rat.
DiJoseph
J F
JF
Division of Immunopharmacology, Wyeth-Ayerst Research, Princeton, NJ 08543-8000.
Wells
C L
CL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors* / Q000633:toxicity; D017259:Dimaprit; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced; D013890:Thiourea / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006635:Histamine H2 Antagonists; D011994:Recombinant Proteins; D000431:Ethanol; D004815:Epidermal Growth Factor; D013890:Thiourea; D007213:Indomethacin; D017259:Dimaprit