Alteration of salt taste sensitivity by the neonatal removal of sublingual glands in the rat.
1. Adult rats with the surgical removal of sublingual glands at their 10 days of age did not prefer NaCl solution of any concentration to water, whereas those with sham-operation or the removal of submandibular glands preferred 0.03 or 0.1 M NaCl to water. 2. Magnitudes of inhibition of chorda tympani responses to NaCl by the lingual treatment of 0.1 mM amiloride were greater in neonatally sublingual removed rats than in sham-operated or submandibular removed ones. 3. These results suggest that the removal of sublingual glands in neonatal period of the rat could increase the amount of the amiloride-sensitive Na receptor mechanism on the taste cell membrane in its adulthood.
Ninomiya
Y
Y
Department of Oral Physiology, Asahi University School of Dentistry, Gifu, Japan.
Katsukawa
H
H
Funakoshi
M
M
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002814:Chorda Tympani Nerve / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D012996:Solutions; D013361:Sublingual Gland / Q000502:physiology* / Q000601:surgery; D013649:Taste / Q000187:drug effects / Q000502:physiology*
D012996:Solutions; D012965:Sodium Chloride; D000584:Amiloride