Electrophoretic mobility of erythrocytes from adeturone-pretreated rats exposed to gamma or high-energy protons.
Change in electrophoretic mobility (EM) of erythrocytes was studied 6 hours after rats were exposed to a dose range (0.5-4 Gy) of high-energy protons (9 GeV/nucleon) or gamma rays (0.660 MeV), with or without adeturone pretreatment (300 mg/kg body weight). With either of the two radiation types used, EM of the cells was observed to undergo significant dose-related decline. As indicated by our findings, adeturone pretreatment failed to contribute to maintenance of normal erythrocyte surface charge in the case of proton irradiation, proving, nevertheless, effective against gamma-ray exposure at all dose levels used.
Vranska
T G
TG
Pantev
T P
TP
Fedorenko
B S
BS
Kabaschenko
A N
AN
Gerasimenko
V N
VN
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D004586:Electrophoresis; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects*; D005720:Gamma Rays; D011522:Protons; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D011522:Protons; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; C012704:Adeturon; D000255:Adenosine Triphosphate