Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme.
Recessive mutations, revealed by loss of the wild-type allele, have been associated with the development of a variety of cancers in children and adults. Polymorphic chromosome 10 markers were used to screen paired tumor and lymphocyte DNA samples in 13 patients with glioblastoma multiforme. Ten patients showed loss of constitutional heterozygosity in the tumor samples. This finding suggests that a recessive gene involved in the development of glioblastoma multiforme is present on chromosome 10.
Fujimoto
M
M
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Fults
D W
DW
Thomas
G A
GA
Nakamura
Y
Y
Heilbrun
M P
MP
White
R
R
Story
J L
JL
Naylor
S L
SL
Kagan-Hallet
K S
KS
Sheridan
P J
PJ
D000483:Alleles; D001254:Astrocytoma / Q000235:genetics; D002879:Chromosomes, Human, Pair 10; D005819:Genetic Markers; D005909:Glioblastoma / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009154:Mutation
D005819:Genetic Markers