[Synaptosomal factors, regulating the activity of Na,K-ATPase and its sensitivity to neurotransmitters].
The factors regulating the activity of synaptosomal Na,K-ATPase have been found in nerve endings cytosol. One of these (Mr 10,000) essentially inhibits, whereas the other one (Mr 60,000) in the presence of norepinephrine, 5-hydroxytryptamine and dopamine activates the Na,K-ATPase of synaptosomes. Regardless of their direct action on Na,K-ATPase, the effect of the activating factor increases in the presence of neurotransmitters. In cell ksap obtained by microsome precipitation the activating factor is absent.
Tsakadze
L G
LG
Kometiani
Z P
ZP
D000818:Animals; D001921:Brain / Q000378:metabolism; D002850:Chromatography, Gel; D004298:Dopamine / Q000494:pharmacology; D006358:Hot Temperature; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D013570:Synaptic Membranes / Q000201:enzymology*
D018377:Neurotransmitter Agents; D012701:Serotonin; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine; D009638:Norepinephrine
Sinaptosomal'nye faktory, reguliruiushchie aktivnost'Na,K-ATPase i ee chuvstvitel'nost' k neĭrotransmitteram.