Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7.
Treatment of young AKR/J mice with N-methyl-N-nitrosourea (MNU) results in the induction of a high incidence of thymic lymphomas occurring between 4 and 6 months of age. The tumor incidence is higher and the latency period is shorter than that observed in other MNU-treated mouse strains. Analysis of tumor incidence in crosses of AKR/J with C57L/J mice indicates that several genes influence the incidence and latency of MNU-induced thymic lymphomas. One of these genes appears to be tightly linked to the albino locus of chromosome 7.
Angel
J M
JM
University of Texas, M.D. Anderson Cancer Center, Science Park-Research Division, Smithville 78957.
Morizot
D C
DC
Richie
E R
ER
D000417:Albinism / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D005808:Genes, Recessive; D005814:Genes, Viral; D009052:Leukemia Virus, Murine / Q000235:genetics; D008223:Lymphoma / Q000139:chemically induced / Q000235:genetics*; D008770:Methylnitrosourea; D051379:Mice; D008806:Mice, Inbred AKR; D013953:Thymus Neoplasms / Q000139:chemically induced / Q000235:genetics*
D008770:Methylnitrosourea