Transmission of the simian immunodeficiency virus SIVmne in macaques and baboons.
A primate lymphotropic lentivirus was isolated on Hut 78 cells after cocultivation of a lymph node from a macaque that died with malignant lymphoma. In earlier studies SIV/Mne was inoculated into 17 macaques and two baboons. All of the macaques became viremic and seropositive. Fifteen of the macaques succumbed to a classic AIDS-like disease, whereas the baboons did not become viremic. The SIV/Mne virus has now been molecularly cloned and inoculated into Macaca nemestrina and baboons. A new transmission study has been initiated to test the effects of route and dosage on disease.
Morton
W R
WR
Regional Primate Research Center, University of Washington, Seattle.
Kuller
L
L
Benveniste
R E
RE
Clark
E A
EA
Tsai
C C
CC
Gale
M J
MJ
Thouless
M E
ME
Overbaugh
J
J
Katze
M G
MG
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D015153:Blotting, Western; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D008251:Macaca / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology; D008254:Macaca nemestrina / Q000382:microbiology; D008992:Monkey Diseases / Q000276:immunology / Q000635:transmission*; D010215:Papio / Q000382:microbiology*; D012192:Retroviridae Infections / Q000276:immunology / Q000635:transmission / Q000662:veterinary*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D014766:Viremia / Q000662:veterinary
D000914:Antibodies, Viral