Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.
Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.
Turk
S R
SR
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109.
Kik
N A
NA
Birch
G M
GM
Chiego
D J
DJ
Shipman
C
C
D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000382:microbiology*; D006651:Histocytochemistry; D009154:Mutation; D012264:Ribonucleotide Reductases / Q000235:genetics*; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics* / Q000502:physiology; D012867:Skin / Q000473:pathology; D014779:Virus Replication
D012264:Ribonucleotide Reductases