title: Synthesis of some 2-(3,4-dimethoxy-phenyl)-1,3-propanediamines as potential dopaminergic agents.
abstract: The bilateral diamino analogs namely N,N'-dialkyl-N,N'-diaralkyl- and N,N,N',N'-tetraalkyl-2-(3,4-dimethoxyphenyl)-1,3-propanediamine s were synthesized. The biochemical determination of the brain levels of dopamine and norepinephrine as well as of brain monoamine oxidase (MAO) activity was performed.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria.
authors.forename: R M
authors.initials: RM
authors.lastname: Shafik
authors.forename: E A
authors.initials: EA
authors.lastname: Ibrahim
authors.forename: E M
authors.initials: EM
authors.lastname: el-Khawass
authors.forename: S A
authors.initials: SA
authors.lastname: el-Hawash
authors.forename: S A
authors.initials: SA
authors.lastname: el-Dardiry
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000138:chemical synthesis*; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008787:Metoclopramide / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
chemical_list: D003959:Diamines; D015259:Dopamine Agents; D008995:Monoamine Oxidase; D008787:Metoclopramide; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine