title: Fetal substantia nigra grafts. Effect on dopamine receptors in the rat corpus striatium.
abstract: Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.
authors.forename: E
authors.initials: E
authors.lastname: Korfali
authors.forename: W D
authors.initials: WD
authors.lastname: Knowles
authors.forename: S
authors.initials: S
authors.lastname: Uysal
authors.forename: I H
authors.initials: IH
authors.lastname: Ulus
authors.forename: T
authors.initials: T
authors.lastname: Ozmen
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology / Q000502:physiology*; D005333:Fetus; D006892:Hydroxydopamines / Q000494:pharmacology; D009417:Nerve Tissue / Q000637:transplantation*; D016627:Oxidopamine; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D013378:Substantia Nigra / Q000637:transplantation*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase