Regression of the malignant aspects of intraepithelial neoplasias following an LH-RH agonist treatment and detection of human papillomavirus by molecular hybridization.
Patients presenting genital intraepithelial neoplasia and/or flat condyloma were treated with DTrp6-LH-RH (triptorelin) to induce a transitory suppression of estrogens. This treatment led in some cases to a complete clinical and histological regression accompanied by a disappearance of human papillomavirus sequences as detected by molecular hybridization.
Kitasato
H
H
Institut du Cancer et d'Immunogénétique, Hôpital Paul-Brousse, Villejuif, France.
Fabiani
B
B
Busuttil
M
M
Reynes
M
M
Hillova
J
J
Hill
M
M
Mathé
G
G
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D027383:Papillomaviridae; D017329:Triptorelin Pamoate; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000209:etiology
D000970:Antineoplastic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone