Temazepam or midazolam for night sedation. A double-blind study.
The effects of oral temazepam (20 mg), oral midazolam (15 mg) and a placebo were compared for night sedation on the evening prior to surgery in a double-blind study. Patients in the placebo group had significantly worse sleep than those in the temazepam (p = 0.004) or midazolam groups (p = 0.04). There was no significant difference between the two drug groups, nor between the residual effects of the three treatments. Temazepam appears to be somewhat more effective than the ultrashort-acting midazolam in pre-operative transient insomnia.
Irjala
J
J
Department of Anaesthesiology, Turku Municipal Hospital, Finland.
Kanto
J
J
Salonen
M
M
D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology; D011229:Preanesthetic Medication; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects*; D013693:Temazepam / Q000008:administration & dosage / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D013693:Temazepam; D008874:Midazolam