title: Effects of pectin on fatty acid and glucose absorption and on thickness of unstirred water layer in rat and human intestine.
abstract: Effects of pectin, a soluble dietary fiber, on fatty acid and glucose absorption were studied in vivo in rats and humans by perfusing the intestine with linoleic acid and glucose solutions with and without pectin. Linoleic acid and glucose absorption decreased with increasing concentrations of pectin. The reduction in linoleic acid absorption was not caused by binding of linoleic acids by pectin or impaired micelle formation due to binding of bile acid by pectin. The unstirred water layer expanded with increasing concentrations of pectin. These results suggest that enlargement of the unstirred water layer is closely associated with the reduction of absorption of fatty acid and glucose ingested with pectin.
authors.affiliation: Second Department of Internal Medicine, Shiga University of Medical Science, Ohtsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fuse
authors.forename: T
authors.initials: T
authors.lastname: Bamba
authors.forename: S
authors.initials: S
authors.lastname: Hosoda
mesh_terms: D000328:Adult; D000818:Animals; D001834:Body Water / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000493:pharmacokinetics; D008297:Male; D010368:Pectins / Q000494:pharmacology*; D011199:Potentiometry; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D008041:Linoleic Acids; D010368:Pectins; D019787:Linoleic Acid; D005947:Glucose