Indeloxazine augments long-term potentiation in the mossy fiber-CA3 system of guinea pig hippocampal slices.
The effects of indeloxazine and piracetam, which reportedly prevent experimental impairments of memory and learning, on long-term potentiation (LTP) of the population spike in the mossy fiber-CA3 system were studied in vitro using the guinea pig hippocampal slices. Indeloxazine (10(-6) M) or piracetam (10(-4) M) significantly augmented the LTP and the effect of indeloxazine on the LTP was approximately 100 times as potent as that of piracetam.
Sugimura
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Ishihara
K
K
Katsuki
H
H
Satoh
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006168:Guinea Pigs; D006624:Hippocampus / Q000648:ultrastructure*; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D000928:Antidepressive Agents; D009025:Morpholines; C020852:indeloxazine; D010889:Piracetam