[Influence of morphine and naloxone on the blast transformation of lymphocytes].
The study on the morphine and naloxone influence on the blastic transformation of lymphocytes were made in vitro. The material was taken from the laryngeal cancer and leukoplakia patients. Morphine lowered the threshold of the blastic transformation especially in laryngeal cancer patients. Naloxone on the other hand exaggerated the transformation. This influence may be caused by the lymphocyte opiate receptors. The knowledge of the interdependence between the nervous and immunologic system may be usefull in understanding of the neoplasms pathology mechanisms and constitute a progress especially in oncologic treatment.
Tarchalska-Kryńska
B
B
Zawisza
E
E
Samoliński
B
B
D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007971:Leukoplakia / Q000473:pathology*; D008214:Lymphocytes / Q000187:drug effects*; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000502:physiology
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine
Wpływ morfiny i naloksonu na przemiany blastyczne limfocytów.