title: Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling.
abstract: We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril, foroxymithine, histargin and pepstatin. In spite of the apparently bizarre movements of the raw data, the analysis with autoregressive modelling unveiled the different modes of feedback regulations of the renin-angiotensin system under the influence of the various inhibitors. In order to interpret the in vivo actions of enzyme inhibitors, it seems essential to take feedback regulations into consideration.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Aoyagi
mesh_terms: D000626:Aminopeptidases / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D005246:Feedback; D043384:Glutamyl Aminopeptidase; D008433:Mathematics; D008962:Models, Theoretical; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011817:Rabbits; D012016:Reference Values; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000803:Angiotensin I; D000626:Aminopeptidases; D043384:Glutamyl Aminopeptidase; D007703:Peptidyl-Dipeptidase A; D012083:Renin