title: [Breast carcinoma with features of osteosarcoma--a light and electron microscopic and immunohistochemical study].
abstract: Reported is the case history of a 58-year-old woman with a lump in the left breast. The tumor was composed of two nodules, sharing a common portion. Grossly, one was an irregular hard tumor that was grayish in color, and the other was a well circumscribed cystic tumor that showed necrosis and a hemorrhage that had filled it with a reddish soft mass. Light microscopically, combined features of a scirrhous carcinoma and of an osteosarcoma were observed in each nodule, but the common portion was consistent with a metaplastic carcinoma, with cancer cells and sarcoma-like cells closely mingled. An ultrastructural study showed that the sarcoma-like cells were composed of polymorphic cells that resembled osteoblasts, myofibroblasts, osteoclasts, histiocytes, and undifferentiated tumor cells. Immunohistochemically, vimentin and alpha 1-antitrypsin in the sarcoma-like cells were positive, suggesting these cells were of a mesenchymal rather than of an epithelial origin.
authors.affiliation: Dept. of Pathology, Kushiro Red Cross Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Horiguchi
authors.forename: K
authors.initials: K
authors.lastname: Nihei
authors.forename: S
authors.initials: S
authors.lastname: Asano
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D008875:Middle Aged; D012516:Osteosarcoma / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D014746:Vimentin; D000515:alpha 1-Antitrypsin