Motoneuron disease: a disorder secondary to solvent exposure?
There seems to be a statistically significant association between work in the leather industry and subsequent development of motoneuron disease. The reason for this association may be occupational exposure to solvents, which may damage motoneurons either directly or through activation of latent virus.
Hawkes
C H
CH
Ipswich Hospital, Suffolk.
Cavanagh
J B
JB
Fox
A J
AJ
D000293:Adolescent; D000328:Adult; D002074:Butanones / Q000009:adverse effects; D002869:Chromosome Aberrations; D005260:Female; D006586:Hexanes / Q000009:adverse effects; D006801:Humans; D008297:Male; D008742:Methyl n-Butyl Ketone / Q000009:adverse effects; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D009154:Mutation; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced* / Q000401:mortality; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects*; D013633:Tanning; D014050:Toluene / Q000009:adverse effects; D006113:United Kingdom; D014775:Virus Activation / Q000187:drug effects
D002074:Butanones; D006586:Hexanes; D012997:Solvents; D014050:Toluene; C005222:methylethyl ketone; D008742:Methyl n-Butyl Ketone