title: Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.
abstract: We have examined the capacity of a series of 6-substituted pyrimidine and 2-substituted purine derivatives to inhibit mammalian thymidine kinase and the thymidine kinases encoded by type 1 and type 2 herpes simplex viruses. Several N2-substituted guanine and deoxy guanosine derivatives displayed selective inhibitory activity against the HSV-1 and HSV-2 thymidine kinases by competing with the phosphorylation of thymidine, suggesting a possible novel pharmacological approach to herpes viruses infections.
authors.affiliation: Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Focher
authors.forename: D
authors.initials: D
authors.lastname: Sandoli
authors.forename: C
authors.initials: C
authors.lastname: Hildebrand
authors.forename: S
authors.initials: S
authors.lastname: Sangalli
authors.forename: G
authors.initials: G
authors.lastname: Ciarrocchi
authors.forename: A
authors.initials: A
authors.lastname: Rebuzzini
authors.forename: G
authors.initials: G
authors.lastname: Pedrali-Noy
authors.forename: R
authors.initials: R
authors.lastname: Manservigi
authors.forename: G
authors.initials: G
authors.lastname: Wright
authors.forename: N
authors.initials: N
authors.lastname: Brown
mesh_terms: D002478:Cells, Cultured; D006367:HeLa Cells; D007700:Kinetics; D009705:Nucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000201:enzymology*; D013936:Thymidine / Q000378:metabolism; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors*
chemical_list: D009705:Nucleosides; D013937:Thymidine Kinase; D013936:Thymidine