Serum protein degradation by hypochlorite.
The structural integrity of serum proteins: albumin, immunoglobulin G, transferrin, ceruloplasmin and superoxide dismutase, and the functional activity of the latter two enzymes after their interaction with hypochlorite were studied. It was shown that the interaction between the proteins and hypochlorite resulted in protein injury and degradation of their native structure. In the case of ceruloplasmin and transferrin, a practically complete protein "dissipation" occurred, the albumin and superoxide dismutase structures being injured in a lesser degree. The inactivation of ceruloplasmin was slower than that of superoxide dismutase. The protein degradation by hypochlorite seems to be the main factor restricting the ability of the proteins to act as antiinflammatory drugs.
Sharonov
B P
BP
All-Union Research Institute of Highly Pure Biopreparations, Pudozhskaja, Leningrad, USSR.
Govorova NJu
Lyzlova
S N
SN
D001798:Blood Proteins; D002570:Ceruloplasmin / Q000037:antagonists & inhibitors; D003300:Copper / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005609:Free Radicals; D006997:Hypochlorous Acid / Q000494:pharmacology; D007074:Immunoglobulin G; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012709:Serum Albumin; D013050:Spectrometry, Fluorescence; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D013481:Superoxides; D014168:Transferrin
D001798:Blood Proteins; D005609:Free Radicals; D007074:Immunoglobulin G; D012709:Serum Albumin; D014168:Transferrin; D013481:Superoxides; D006997:Hypochlorous Acid; D003300:Copper; D013482:Superoxide Dismutase; D002570:Ceruloplasmin