title: Study of inhibition of platelet aggregation of 1,8-naphthyridine derivatives.
abstract: The antiplatelet activity of some 1,8-naphthyridine derivatives was studied. The compounds displayed different abilities in blocking the effects of ADP, collagen and arachidonic acid. Four of them showed an in vitro remarkable activity similar to that of dipyridamole and papaverine.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica Dell'Università di Pisa.
authors.forename: P
authors.initials: P
authors.lastname: Ferrarini
authors.forename: C
authors.initials: C
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Criscuoli
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004176:Dipyridamole / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009287:Naphthyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009287:Naphthyridines; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D010208:Papaverine; D015105:3',5'-Cyclic-AMP Phosphodiesterases