Fatal acute interstitial pneumonia induced by low-dose doxorubicin and vindesine.
A 53-year-old female smoker with small cell carcinoma of the lung with cerebral metastases was initially treated with whole brain radiation with favorable responses. She developed fulminant and fatal interstitial pneumonia following administration of 30 mg of doxorubicin and 6 mg of vindesine. Histopathology revealed that the interstitial pneumonia was compatible with a drug-induced pneumonia.
Isawa
T
T
Department of Medicine, Tohoku University, Sendai, Japan.
Ono
R
R
Motomiya
M
M
Tamahashi
N
N
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects*
D004317:Doxorubicin; D014751:Vindesine