title: Effects of long-term xamoterol therapy on the left ventricular mechanical efficiency in patients with ischemic heart disease.
abstract: Myocardial oxygen uptake and an index of mechanical left ventricular efficiency were determined in basal conditions or during prolonged therapy with the new beta 1-adrenoceptor partial agonist xamoterol in 16 patients with mild to moderate ischemic heart failure. During xamoterol therapy, left ventricular end-diastolic pressure decreased from 24.4 +/- 6.5 to 17.8 +/- 8.6 mm Hg (P less than 0.01) and the isovolumic index of inotropic state (dP/dt)/DP40 increased by 14% (P less than 0.01). The heart rate increased slightly and the mean systolic and peak systolic wall stress also tended to increase (+ 7%; NS) but myocardial oxygen uptake (14.1 vs 14.7 ml/min; NS) and the index of efficiency (8.77 +/- 3.44 to 8.82 +/- 4.27; NS) were not significantly modified. In conclusion, prolonged therapy with xamoterol was not accompanied by a deterioration in the mechanical efficiency of the ventricle, even in patients with ischemic heart disease.
authors.affiliation: Department of Physiology, University of Louvain, Brussels, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Pouleur
authors.forename: C
authors.initials: C
authors.lastname: van Eyll
authors.forename: J
authors.initials: J
authors.lastname: Etienne
authors.forename: H
authors.initials: H
authors.lastname: van Mechelen
authors.forename: A
authors.initials: A
authors.lastname: Vuylsteke
authors.forename: M F
authors.initials: MF
authors.lastname: Rousseau
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D011412:Propanolamines / Q000494:pharmacology*; D017307:Xamoterol
chemical_list: D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D017307:Xamoterol