[Antibiotic resistance plasmids from Serratia marcescens and their elimination by DNA-gyrase inhibitors].
We studied the effects of ciprofloxacin on 73 strains of Serratia marcescens. In the first place, we have tested their plasmidic content: 76% of Serratia marcescens strains contained plasmids by electrophoresis, and 29% of these plasmids were self-transmissible by conjugation. Secondly, we studied the plasmid stability with regard to ciprofloxacin. We obtained a spontaneous cure with 19% of plasmids, and ciprofloxacin, at very low concentrations (0.4 mg/l), increased the rate of cure and more efficiently than novobiocin, a compound used as a known curing agent.
Llanes
C
C
CNRS URA 531, Faculté de Médecine, Université de Franche-Comté, Besançon.
Michel-Briand
Y
Y
Couturier
M
M
Thouverez
M
M
Bailly
C
C
D015373:Bacterial Typing Techniques; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D010957:Plasmids / Q000187:drug effects*; D012703:Serotyping; D012706:Serratia marcescens / Q000145:classification / Q000235:genetics*; D059005:Topoisomerase II Inhibitors
D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin
Les plasmides de résistance aux antibiotiques de Serratia marcescens et leur élimination par les inhibiteurs de l'ADN-gyrase.