title: Variation in some enzymes in amniotic fluid and maternal serum during pregnancy.
abstract: The following 10 enzymes were assayed in 187 amniotic fluid and maternal serum samples at 15-42 weeks of gestation: alkaline phosphatase, heat-stable alkaline phosphatase (only in amniotic fluid), acid phosphatase, alanine aminotransferase, aspartate aminotransferase, alpha-amylase, gamma-glutamyltransferase, creatine kinase, lactate dehydrogenase, and lysozyme. The normal reference ranges are reported for amniotic fluid and maternal serum enzymes, together with the abnormal values accompanying neural tube defects and EPH-gestosis. The determination of gamma-glutamyltransferase, heat-stable alkaline phosphatase and creatine kinase was found to be of appreciable diagnostic significance in clinical practice.
authors.affiliation: Department of Paediatrics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Salgó
authors.forename: A
authors.initials: A
authors.lastname: Pál
mesh_terms: D000653:Amniotic Fluid / Q000201:enzymology*; D003402:Creatine Kinase / Q000378:metabolism; D004798:Enzymes / Q000097:blood*; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000201:enzymology*; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy / Q000378:metabolism*; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D004798:Enzymes; D005723:gamma-Glutamyltransferase; D003402:Creatine Kinase