[The amount of thrombocyte alpha 2-adrenoreceptors in patients with different clinical variants in the course of ischemic heart disease].
Number of alpha-2-adrenoceptors on the thrombocyte membranes was measured with selective antagonists [H]3 yohimbine in 25 patients with ischemic heart disease (7 patients with unstable 12 with vasospastic and 6 with new onset angina pectoris) and in 16 patients without ischemic heart disease and coronary atherosclerosis (control group). The number of alpha-2-adrenoceptors in patients with unstable angina pectoris (571.0 +/- 92.9) was proved to exceed significantly that in patients with vasospastic (237.9 +/- 30.0) or new onset angina (126.2 +/- 19.3) and in the control group (200.0 +/- 22.5). The number of adrenoceptors tended to decrease during myocardial ischemia.
Prusskikh
G A
GA
Shartava
A Sh
ASh
Shakhov
Iu A
IuA
Gratsianskiĭ
N A
NA
D000293:Adolescent; D000328:Adult; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood; D001792:Blood Platelets / Q000032:analysis*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects; D011869:Radioligand Assay / Q000379:methods; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*
D011942:Receptors, Adrenergic, alpha
Kolichestvo al'fa 2-adrenoretseptorov trombotsitov u bol'nykh s razlichnymi klinicheskimi variantami techeniia ishemicheskoĭ bolezni serdtsa.