Adenosine inhibits renin release induced by suprarenal-aortic constriction and prostacyclin.
The purpose of this study was to determine whether adenosine can attenuate the renin release response to a reduction in renal perfusion pressure. To this end, the secretion rate of renin was measured in six beta-blocked dogs at ambient arterial blood pressure and after a reduction of renal perfusion pressure to 80 mm Hg. These measurements were made during a control period, an intrarenal infusion of adenosine at 10 and 30 micrograms/min, and a recovery period. During the control and recovery periods renal artery hypotension significantly increased the secretion rate of renin. However, during the intrarenal infusions of adenosine, renin secretion rate did not increase significantly. Analysis of variance indicated that both doses of adenosine reduced the renin response to renal artery hypotension. In another six dogs with a single nonfiltering kidney, we again measured renin secretion during a control period, the intrarenal infusion of adenosine at 10 and 30 micrograms/min, and a recovery period; however, in this study PGI2 was used to stimulate renin release. Adenosine also significantly attenuated the renin release response to PGI2. We conclude that adenosine can inhibit the renin release response to both renal artery hypotension and PGI2 and that this effect is most likely mediated by a direct action of adenosine on juxtaglomerular cells. Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.
Deray
G
G
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Branch
R A
RA
Ohnishi
A
A
Jackson
E K
EK
D000241:Adenosine / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology*; D004285:Dogs; D004492:Edetic Acid / Q000494:pharmacology; D011464:Epoprostenol / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D004492:Edetic Acid; D011464:Epoprostenol; D012083:Renin; D000241:Adenosine