Coxsackievirus B3 myocarditis in C3H/HeJ mice: description of an inbred model and the effect of exercise on virulence.
The effect of forced exercise on the development of coxsackievirus B3 myocarditis in inbred C3H/HeJ mice was studied. Four groups of mice (30 per group) were formed: infected-exercised (Group I); infected-unexercised (Group II); uninfected-exercised (Group III); and uninfected-unexercised (Group IV). Infected mice were inoculated intraperitoneally with 1.0 x 10(2.1) TCID50 coxsackievirus B3. Exercised animals were swum daily for 60 minutes on days 1-9. Myocardial viral titers were acutely elevated on day 3 of infection and were augmented significantly by exercise on days 6 and 9. Exercise increased the overall mortality from 0-10% to 20-40%; significantly increased heart: body weight ratios on days 6, 9 and 13; and increased the extent of myocardial fiber necrosis. We have reproduced the acceleration of CB3 myocarditis by exercise in the inbred C3H model.
Kiel
R J
RJ
Department of Medicine, Wayne State University, Detroit, MI.
Smith
F E
FE
Chason
J
J
Khatib
R
R
Reyes
M P
MP
D000818:Animals; D001835:Body Weight; D003384:Coxsackievirus Infections / Q000276:immunology / Q000401:mortality / Q000473:pathology; D004195:Disease Models, Animal; D029822:Enterovirus B, Human / Q000276:immunology / Q000472:pathogenicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology / Q000382:microbiology*; D009205:Myocarditis / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D005082:Physical Exertion; D013550:Swimming; D014774:Virulence