Characterization of 5-hydroxytryptamine3 receptors in the medial prefrontal cortex: a microiontophoretic study.
The microiontophoretic application of the selective 5-hydroxytryptamine3 (5-HT3) agonist 2-methylserotonin suppresses medial prefrontal cortex cell firing. This effect is blocked by the 5-HT3 antagonists BRL 43694 and ICS205930, but not by metergoline or (+/-)-pindolol. Continuous microiontophoretic administration of magnesium chloride or the gamma-aminobutyric acidA antagonist SR 95103 did not alter 2-methylserotonin's suppressant action, suggesting that this effect is direct. Our results suggest that 5-HT3 receptors have a functional role in the medial prefrontal cortex.
Ashby
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Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8790.
Edwards
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E
Harkins
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Wang
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RY
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D017829:Granisetron; D007191:Indazoles / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007478:Iontophoresis; D015636:Magnesium Chloride / Q000494:pharmacology; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D000077526:Tropisetron; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D017829:Granisetron; D007191:Indazoles; D007211:Indoles; D015636:Magnesium Chloride; D008711:Metergoline; D011985:Receptors, Serotonin; D012701:Serotonin; D012702:Serotonin Antagonists; D000077526:Tropisetron; D005680:gamma-Aminobutyric Acid; C045918:2-methyl-5-HT