title: Regression of the malignant aspects of intraepithelial neoplasias following an LH-RH agonist treatment and detection of human papillomavirus by molecular hybridization.
abstract: Patients presenting genital intraepithelial neoplasia and/or flat condyloma were treated with DTrp6-LH-RH (triptorelin) to induce a transitory suppression of estrogens. This treatment led in some cases to a complete clinical and histological regression accompanied by a disappearance of human papillomavirus sequences as detected by molecular hybridization.
authors.affiliation: Institut du Cancer et d'Immunogénétique, Hôpital Paul-Brousse, Villejuif, France.
authors.forename: H
authors.initials: H
authors.lastname: Kitasato
authors.forename: B
authors.initials: B
authors.lastname: Fabiani
authors.forename: M
authors.initials: M
authors.lastname: Busuttil
authors.forename: M
authors.initials: M
authors.lastname: Reynes
authors.forename: J
authors.initials: J
authors.lastname: Hillova
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: G
authors.initials: G
authors.lastname: Mathé
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D027383:Papillomaviridae; D017329:Triptorelin Pamoate; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone