In vitro interaction of mutagenic chromium (VI) with red blood cells.
The interaction of mutagenic Cr(VI) with red blood cells has been studied by ESR spectroscopy. Signals of two Cr(V) species are observed almost immediately after contacting red cells with chromate(VI) aqueous solution at pH 7.4. The signal at go = 1.985, which decays within one hour, is attributed to a Cr(V) complex formed by glutathione due its reducing and chelating ability. The other signal at go = 1.979, which is distinctly more persistent, may indicate that some immobilization of the formed Cr(V) ions takes place on the macromolecular cell components, e.g. glycoproteins.
Branca
M
M
Dipartimento di Chimica, Università di Sassari, Italy.
Dessi
A
A
Kozlowski
H
H
Micera
G
G
Serra
M V
MV
D000328:Adult; D002840:Chromates / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005033:Ethylmaleimide / Q000494:pharmacology; D005978:Glutathione / Q000097:blood; D006801:Humans; D009153:Mutagens
D002840:Chromates; D009153:Mutagens; D005978:Glutathione; D005033:Ethylmaleimide