title: [The action of naloxone on monocyte chemotaxis in heroin addicts].
abstract: Intravenous (I.V.) drug users possess a decrease of the monocyte chemotaxis directly related to drug usage. We study the effects of naloxone on monocyte chemotaxis in I.V. drug users, evaluating the chemotactic index and the cellular level of cAMP. The incubation of monocytes with naloxone did not modify the chemotactic index nor the cellular levels of cAMP, the first remaining low and the second high, this being statistically significant compared with the control group. We comment on the possible causes of naloxone's lack of effect and we suggest the role of cAMP in causing the chemotactic defect in this group of patients.
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez Castrillón
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez Arellano
authors.forename: J D
authors.initials: JD
authors.lastname: García Palomo
authors.forename: M
authors.initials: M
authors.lastname: Martín Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Jiménez López
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002908:Chronic Disease; D000242:Cyclic AMP / Q000097:blood; D006556:Heroin Dependence / Q000097:blood*; D006801:Humans; D008722:Methods; D009000:Monocytes / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*
chemical_list: D009270:Naloxone; D000242:Cyclic AMP
vernacular_title: Acción de la naloxona sobre la quimiotaxis monocitaria de heroinómanos.