title: The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat.
abstract: The level of somatostatin in the hypothalamus was higher in satiated rats than in hungry rats. Elevating hypothalamic somatostatin levels by administering somatostatin into the hypothalamus produced a decrease in food intake, whereas lowering hypothalamic somatostatin levels by administering cysteamine into the peritoneal cavity produced an increase in food intake in rats.
authors.affiliation: Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan.
authors.forename: L T
authors.initials: LT
authors.lastname: Ho
authors.forename: Y F
authors.initials: YF
authors.lastname: Chern
authors.forename: M T
authors.initials: MT
authors.lastname: Lin
mesh_terms: D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D006815:Hunger / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000502:physiology; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*
chemical_list: D013004:Somatostatin; D003543:Cysteamine