Evidence for the involvement of the central adrenergic system in interleukin 1-induced adrenocortical response.
The role of central catecholamines in the mediation of adrenocortical activation, induced by interleukin 1 (IL-1), was investigated by measuring ACTH and corticosterone in serum. Adult male rats were injected with either vehicle or the neurotoxin 6-hydroxydopamine (6-OHDA) into the lateral ventricle or the ventral noradrenergic ascending bundle. In vehicle-injected rats, 2 U of IL-1, injected intraventricularly, produced a 5- and 15-fold increase in ACTH and CS, respectively, in serum, 120 min after the injection of IL-1. In contrast, 6-OHDA, injected either intraventricularly or into the ventral noradrenergic ascending bundle, abolished the response to an intracerebral injection of IL-1. In addition, in rats pretreated with the alpha 1-adrenergic antagonist, prazosin, IL-1 failed to activate the adrenocortical axis. In other rats pretreated with the beta-adrenergic antagonist, propranolol, the adrenocortical response did not significantly differ from that of vehicle-pretreated rats. These results suggest that central adrenergic transmission, originating at the ventral noradrenergic ascending bundle and acting through alpha 1-adrenergic receptors, is involved in the adrenocortical response to IL-1.
Weidenfeld
J
J
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Abramsky
O
O
Ovadia
H
H
D000302:Adrenal Cortex / Q000187:drug effects* / Q000294:innervation; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D006892:Hydroxydopamines / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D016627:Oxidopamine; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology
D002395:Catecholamines; D006892:Hydroxydopamines; D007375:Interleukin-1; D011994:Recombinant Proteins; D013565:Sympatholytics; D016627:Oxidopamine; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone