Increased furosemide-sensitive sodium influx into erythrocytes in non-insulin-dependent diabetes mellitus associated with hypertension.
Our previous study demonstrated increased sodium (Na+) influx into ouabain-treated erythrocytes in diabetic patients with hypertension. The present study was designed to estimate the effect of furosemide on the Na+ influx in non-insulin-dependent diabetes mellitus (NIDDM) with hypertension. Both Na+ influx in the absence of furosemide (total Na+ influx; TNaI) and furosemide-sensitive Na+ influx (FSNaI) were increased in patients with essential hypertension (group 1, n = 22) than those in non-diabetic, normotensive control subjects without family history of hypertension (control group, n = 26, P less than 0.001 and P less than 0.001, respectively). TNaI and FSNaI in diabetic patients without hypertension (group 2, n = 28) were also higher than those in the control group (P less than 0.02 and P less than 0.001, respectively), but no significant differences were found in TNaI or FSNaI between groups 1 and 2. TNaI and FSNaI in diabetic patients with hypertension (group 3, n = 19) were elevated than those in control group (P less than 0.001 and P less than 0.001, respectively), in group 1 (P less than 0.05 and P less than 0.02, respectively) and in group 2 (P less than 0.001 and P less than 0.001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Chimori
K
K
Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
Miyazaki
S
S
Goi
R
R
Dodo
S
S
Hayashi
H
H
Izai
M
M
Goto
S
S
Yasuda
K
K
Miura
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000008:administration & dosage; D011188:Potassium / Q000032:analysis; D012414:Rubidium Radioisotopes / Q000378:metabolism; D012964:Sodium / Q000032:analysis / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects*
D012414:Rubidium Radioisotopes; D015222:Sodium Channels; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D011188:Potassium