[Changes in pain reactions and 3H-naloxone binding to opiate receptors of the hypothalamus and midbrain in rats after repeated swimming in cold water].
The dynamics of nociceptive reactions and character of 3H-naloxone binding to hypothalamus and midbrain synaptic membranes were studied in rats subjected to repeated cold swim stress (3 min. daily during 3, 5 and 15 days). It was shown that an increase of latencies of background nociceptive reactions (hot-plate and tail-flick tests) was accompanied by an ambiguous changes of kinetic parameters of 3H-naloxone binding in the studied brain structures. The results suggest that an increase of antinociceptive systems tone under repeated cold swim stress may be caused by a dynamic transformation of opiate u-receptor apparatus in various brain structures.
Bragin
E O
EO
Popkova
E V
EV
Vasilenko
G F
GF
D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D007031:Hypothalamus / Q000378:metabolism*; D008636:Mesencephalon / Q000378:metabolism*; D009270:Naloxone / Q000493:pharmacokinetics*; D010146:Pain / Q000503:physiopathology*; D011869:Radioligand Assay; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D011957:Receptors, Opioid / Q000032:analysis / Q000378:metabolism*; D013550:Swimming; D013997:Time Factors; D014316:Tritium
D011957:Receptors, Opioid; D014316:Tritium; D009270:Naloxone
Izmenenie bolevykh reaktsiĭ i sviazyvaniia 3H-naloksona s opiatnymi retseptorami gipotalamusa i srednego mozga krys posle mnogokratnogo plavaniia v kholodnoĭ vode.