[Biological activity of gamma interferon on various cell types in human and murine systems].
The effects of interferon (IFN gamma) and of IFN alpha/beta on normal T and B lymphocytes and various T and non-T human and murine cell lines have been investigated. IFN gamma, unlike IFN alpha/beta, did not promote the antiviral state in T cells. The lack of antiviral activity was confirmed at the biochemical level by the finding that 2',5' oligoadenylate synthetase activity is not induced in T cells by IFN gamma only.
Zucca
M
M
Istituto di Microbiologia dell'Università di Torino.
Fiscella
M
M
Gribaudo
G
G
Musso
T
T
Cavallo
G
G
Landolfo
S
S
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000653:Amniotic Fluid / Q000166:cytology; D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D013045:Species Specificity; D013601:T-Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology
D007370:Interferon Type I; D007371:Interferon-gamma; D015088:2',5'-Oligoadenylate Synthetase
Attività biologica dell'interferon gamma su diversi tipi cellulari in sistemi umani e murini.