Lipid peroxidation, iron mobilization and radical generation induced by alcohol.
Increasing evidence points to a major role for free radicals in the pathogenesis of alcohol-induced liver injury. In vitro, free radicals may be generated during ethanol metabolism by the further metabolism of acetaldehyde by molybdenum-dependent oxidases such as xanthine oxidase. Ferritin iron mobilized by such free radicals may serve as catalytic iron. Increased stores of ferritin iron and induction of microsomal P-450 reductase activity are mechanisms by which chronic alcohol feeding may potentiate the acute effects of alcohol.
Shaw
S
S
General Medical Research, VA Medical Center, Bronx, New York.
D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D005492:Folic Acid / Q000378:metabolism; D005609:Free Radicals; D007501:Iron / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013481:Superoxides / Q000378:metabolism
D005609:Free Radicals; D013481:Superoxides; D000431:Ethanol; D005492:Folic Acid; D007501:Iron