Activators and inactivators of calcium channels: effects in the central nervous system.
The interactions of calcium antagonists or channel activators with the different classes of calcium channel are reviewed with particular emphasis on interactions with neuronal tissue; reasons for the failure of calcium antagonists to inhibit neurotransmitter release under normal circumstances are outlined. Calcium antagonists may be protective in several pathological situations and the possibilities of protection against ischaemic damage in the central nervous system are evaluated.
Spedding
M
M
Syntex Research Centre, Research Park, Riccarton, Edinburgh, Scotland, UK.
Kilpatrick
A T
AT
Alps
B J
BJ
Speddings
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D006801:Humans
D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D015220:Calcium Channels