[A preclinical evaluation of the antianginal activity of energy metabolism intermediates].
In acute experiments on dogs and cats with occlusion of the coronary arteries the antianginal activities of malate (100 mg/kg) and NAD (0.2 mg/kg) were studied. The drugs were found to increase the collateral blood flow and the contractile activity of the myocardium against the background of a moderate rise of the heart oxygen consumption and to normalize the systemic hemodynamics parameters.
Kostin
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D000208:Acute Disease; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002415:Cats; D002952:Citric Acid Cycle; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D003574:Cytochrome c Group / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D007656:Ketoglutaric Acids / Q000627:therapeutic use; D008297:Male; D008298:Maleates / Q000627:therapeutic use; D009243:NAD / Q000627:therapeutic use; D009249:NADP / Q000627:therapeutic use; D013386:Succinates / Q000627:therapeutic use; D019802:Succinic Acid; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
D002317:Cardiovascular Agents; D003574:Cytochrome c Group; D007656:Ketoglutaric Acids; D008298:Maleates; D013386:Succinates; D009243:NAD; D014451:Ubiquinone; C001341:hexahydroubiquinone-4; D009249:NADP; C030272:maleic acid; D019802:Succinic Acid
Doklinicheskaia otsenka antiagninal'noĭ aktivnosti nekotorykh intermediatov énergeticheskogo obmena.