[Polymorphism of restriction fragments of the Ha-ras-1 protooncogene in patients with carcinoma and ulcers of the stomach].
Ha-ras restriction fragments' length polymorphism (RFLP) in white blood cells and stomach tissues from patients with carcinoma and ulcer of the stomach was examined. Genomic DNAs were digested with Xho I, Pvu II, Pst I, Msp I, Bcn I, Mva I, Bsp RI. No Ha-ras-1 polymorphic variants specifically associated with the cancer disease were detected. RFLP of the 3'-noncoding sequence of c-Ha-ras-1 gene had got features of the definite human population. The cells forming the tissue were examined and individual peculiarity of the methylated residues disposition seemed to influence RFLP of the 5'-noncoding sequence of c-Ha-ras-1.
Novikov
L B
LB
Fedorov
S N
SN
Iatsuk
O S
OS
Tlevlesov
N Ia
NIa
Levanova
G I
GI
Kalinovskiĭ
V P
VP
Seĭts
I F
IF
D004247:DNA / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010437:Peptic Ulcer / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D011519:Proto-Oncogenes; D013274:Stomach Neoplasms / Q000235:genetics*
D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D004247:DNA; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Polimorfizm restriktsionnykh fragmentov protoonkogena Ha-ras-1 u bol'nykh kartsinomoĭ i iazvoĭ zheludka.