title: A clinical-pathologic-biochemical study of the membrane surrounding loosened and nonloosened total hip arthroplasties.
abstract: The clinical and roentgenologic data from 31 excised components from 19 revision arthroplasty cases were correlated with the histology and biochemistry of the membrane at the bone-cement or bone-prosthesis interface. Twenty-seven components were cemented and four were uncemented. Twenty-four implants were clinically and roentgenologically loose, one was possibly loose, and six were well fixed. Loose components, whether cemented or not, demonstrated statistically higher prostaglandin E2 levels in the surrounding membrane compared to the nonloose group. Collagenase and M-collagenase levels were absent or insignificantly low in all specimens; no detectable interleukin 1 beta was found. This suggests that prostaglandin E2 may be associated with the bone lysis associated with prosthesis loosening.
authors.affiliation: Division of Orthopaedic Surgery, Stanford University Medical Center, CA 94305-5326.
authors.forename: S B
authors.initials: SB
authors.lastname: Goodman
authors.forename: R C
authors.initials: RC
authors.lastname: Chin
authors.forename: S S
authors.initials: SS
authors.lastname: Chiou
authors.forename: D J
authors.initials: DJ
authors.lastname: Schurman
authors.forename: S T
authors.initials: ST
authors.lastname: Woolson
authors.forename: M P
authors.initials: MP
authors.lastname: Masada
mesh_terms: D001843:Bone Cements; D015232:Dinoprostone / Q000378:metabolism; D006622:Hip Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000032:analysis; D003012:Microbial Collagenase / Q000096:biosynthesis; D011475:Prosthesis Failure; D012086:Reoperation; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology
chemical_list: D001843:Bone Cements; D007375:Interleukin-1; D003012:Microbial Collagenase; D015232:Dinoprostone