[Ion conductance channels of bilayer from sarcoma-45 phospholipids].
Properties of black bilayer membranes formed from sarcoma-45 phospholipids differed from those of normal cell phospholipids bilayers. Two types of Ca2+-channels were discovered: those multiple to 35 pA and those multiple to 90 pA. The study of bilayers from phospholipids of nuclei, mitochondria, microsomal fractions showed that Ca2+-channels were localized in the microsomal fraction of transformed cells. The relationship between DB18C6 diacetylderivatives membrane activity and their effect to growth of sarcoma-45 in vivo was discovered: the Ca2+-channel blocker diacetyl-DB18C6 inhibited the transformed cells growth.
Mirkhodzhaev
U Z
UZ
Boldyrev
V A
VA
Tashmukhamedova
A K
AK
Tatarskiĭ
V P
VP
Dimant
I N
IN
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D043844:Crown Ethers; D004988:Ethers, Cyclic / Q000494:pharmacology; D008051:Lipid Bilayers; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
D015220:Calcium Channels; D043844:Crown Ethers; D004988:Ethers, Cyclic; D008051:Lipid Bilayers; D010743:Phospholipids; C002564:dibenzo-18-crown-6
Ionnye kanaly provodimosti bisloev iz fosfolipidov sarkomy-45.