Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.
The aspartic endopeptidase cathepsin D was immunolocalized in 21 human cadaver brains from patients with dementia and controls. Immunoreactive cathepsin D was found to be present in multiple neurons, neuritic plaques, some macroglial cells, and microvessels. It is suggested that the enzyme might be involved in certain posttranslational changes of cystoskeletal compounds that lead to the formation and/or further growth of neuritic plaques and neurofibrillary tangles.
Bernstein
H G
HG
Institute of Anatomy, Medical Academy, Magdeburg.
Bruszis
S
S
Schmidt
D
D
Wiederanders
B
B
Dorn
A
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002402:Cathepsin D / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002402:Cathepsin D