title: Elevated IgA antibodies to Epstein-Barr virus in children with chronic active Epstein-Barr virus infection.
abstract: Anti-Epstein-Barr virus (EBV) antibodies were tested in 11 children with chronic active EBV infection. Anti-virus capsid antigen (VCA)-IgG antibody titers ranged from 1:640 to 1:10,240. Anti-VCA-IgM antibody was consistently positive in 5 of the 11 patients; anti-VCA-IgA antibody was consistently positive in 6 of the 10 patients; anti-early antigen (EA)-IgG antibody was consistently positive in 10 of the 11 patients and anti-EA-IgA antibody was consistently positive in 4 out of the 7 patients. Anti-EBV nuclear antigen (EBNA) antibody was not detected in two patients. Consistently positive anti-VCA-IgA- and anti-EA-IgA- antibody may be a characteristic feature of abnormal antibody responses in severe chronic active EBV-infection in childhood.
authors.affiliation: Department of Pediatrics, Kochi Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: M
authors.initials: M
authors.lastname: Fujieda
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Wakiguchi
authors.forename: T
authors.initials: T
authors.lastname: Kurashige
authors.forename: M
authors.initials: M
authors.lastname: Oda
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A