[An attempt to estimate various characteristics of neuro-muscular transmission from the rising phase of miniature end-plate currents].
A simple expression describing the relation between the duration of rising phase and amplitude of miniature end-plate currents (MEPC) is suggested. Parameters of MEPC of the rat diaphragm with different degrees of acetylcholinesterase inhibition by galanthamine were used to estimate the lower levels of acetylcholine diffussion coefficient (0.86.10-6 cm2/s) and channel opening rate constant (21000 s-1).
Krivoĭ
I I
II
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D005702:Galantamine / Q000494:pharmacology; D009045:Motor Endplate / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission
D002800:Cholinesterase Inhibitors; D005702:Galantamine; D000109:Acetylcholine
Popytka otsenki nekotorykh kharakteristik nervno-myshechnoĭ peredachi po voskhodiashcheĭ faze miniatiurnykh tokov kontsevoĭ plastinki.