Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker.
A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).
Fujita
R
R
U.184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.
Agid
Y
Y
Trouillas
P
P
Seck
A
A
Tommasi-Davenas
C
C
Driesel
A J
AJ
Olek
K
K
Grzeschik
K H
KH
Nakamura
Y
Y
Mandel
J L
JL
Hanauer
A
A
D002899:Chromosomes, Human, Pair 9; D015252:Deoxyribonucleases, Type II Site-Specific; D005621:Friedreich Ataxia / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007370:Interferon Type I / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D007370:Interferon Type I; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases