Stabilization of the attenuated poliovirus type 3 vaccine strain by sucrose.
Highly temperature-sensitive and attenuated poliovirus type 3, strain Leon 12a1b, was stabilized at 37 degrees C by 15% sucrose without 1 mol/1 MgCl2. The finding will contribute to poliovaccination in tropical countries.
Srivastava
A K
AK
Department of Virology, Nagasaki University, Japan.
D004355:Drug Stability; D004356:Drug Storage; D011055:Poliovirus Vaccine, Oral; D013395:Sucrose / Q000494:pharmacology*; D013696:Temperature; D014613:Vaccines, Attenuated
D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated; D013395:Sucrose