title: DNA duplex with the potential to change handedness after every half a turn.
abstract: Polymorphic forms of the DNA duplex with long stretches of structural monotony are known. Several alternating purine-pyrimidine sequences have been shown to adopt left-handed Z-conformation. We report a DNA sequence d(CGCGCGATCGAT)n exhibiting alternating right-handed B and left-handed Z helical conformation after every half a turn. Further, this unusual conformation with change in handedness after every six base pairs was induced at physiological superhelical density.
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
authors.forename: S K
authors.initials: SK
authors.lastname: Brahmachari
authors.forename: R K
authors.initials: RK
authors.lastname: Mishra
authors.forename: R
authors.initials: R
authors.lastname: Bagga
authors.forename: N
authors.initials: N
authors.lastname: Ramesh
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000648:ultrastructure*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004278:DNA, Superhelical / Q000648:ultrastructure; D004587:Electrophoresis, Agar Gel; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010957:Plasmids; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism
chemical_list: D004278:DNA, Superhelical; D004247:DNA; D004262:DNA Restriction Enzymes; D015719:Single-Strand Specific DNA and RNA Endonucleases