title: [The glucose tolerance test and insulin secretion test as risk factors in liver cancer surgery].
abstract: To investigate the predictive value of oral glucose tolerance test (O-GTT) and insulin secretion test (IST) on the risk of hepatectomy in liver cancer patients, we through double-blind method, compared the results of these two tests, clinical course of the patients, and the pathological findings. It was found that: 1) The positive prediction value, negative prediction value, and accuracy of O-GTT were 79.2%, 94.4%, and 85.7%, the corresponding figures of IST were 55.6%, 100%, and 61.9%, respectively. 2) Pattern of the curve of O-GTT believed to depend on roughly normal hepatic energy metabolism and islet secretion capacity suggested better tolerance for hepatectomy. 3) A part of the patients with advanced HCC had a depressed islet secretion capacity. 4) The delta IST/delta O-GTT showed an accurate negative prediction for hepatectomy when the ratio was less than 50 x 10(-9). 5) Apart from O-GTT and delta IST/delta O-GTT, the severity of the hepatitis and cirrhosis should be taken into account in the decision of carrying out hepatectomy.
authors.forename: T F
authors.initials: TF
authors.lastname: Wen
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000601:surgery*; D004311:Double-Blind Method; D005951:Glucose Tolerance Test; D006498:Hepatectomy; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008113:Liver Neoplasms / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin