title: The role of impairment of adrenal mineraloglucocorticoid function in the development of infertility in varicocele patients.
abstract: The study was aimed at the understanding of pathophysiological mechanisms of the impairment of spermatogenesis in varicocele patients. The crucial role of tension increase in the venous plexus of the spermatic cord in spermatogenesis damage in the testis on the varicocele side and absence of any effect of haemodynamic abnormalities on spermatogenesis in the complementary testis has been determined. Retrograde blood flow through the central vein of the left adrenal gland in varicocele has been evidenced by X-ray examination. The role of this phenomenon in the changes of functional activity of the adrenal gland is discussed. Results of the study of functional status of adrenal glands revealed their tendency to provide hyperactivity in synthesis of mineraloglucocorticoids. Correlation between cortisol level in peripheral blood and percentage of abnormal sperm in ejaculate was shown. This fact supported the idea about the existence of a causal interrelationship between abnormalities in the functional status of adrenal glands and development of infertility in varicocele patients.
authors.affiliation: Urologic and Operative Nephrology Clinic of the Pirogov 2nd Medical Institute, Moscow, USSR.
authors.forename: E B
authors.initials: EB
authors.lastname: Mazo
authors.forename: M V
authors.initials: MV
authors.lastname: Koryakin
authors.lastname: Kudryavtsev JuV
authors.forename: L P
authors.initials: LP
authors.lastname: Evseev
authors.forename: A S
authors.initials: AS
authors.lastname: Akopyan
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000098:blood supply / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000450:Aldosterone / Q000097:blood; D006439:Hemodynamics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D011859:Radiography; D012082:Renal Veins / Q000000981:diagnostic imaging; D013091:Spermatogenesis; D014646:Varicocele / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone