Can disulfiram (Antabuse) be safely co-administered with the monoamine oxidase inhibitor (MAOI) antidepressants? Despite the ability of the major metabolite of disulfiram (diethyldithiocarbamate) to inhibit the enzyme dopamine beta-hydroxylase and a report of the induction in rats of central motor disturbances, convulsions, and death following the co-administration of tranylcypromine, there appears to be surprisingly little in the literature that directly addresses this question.
Ciraulo
D A
DA
Tufts University School of Medicine, Boston, Massachussetts.
D000818:Animals; D004221:Disulfiram / Q000633:toxicity*; D004050:Ditiocarb / Q000633:toxicity*; D004357:Drug Synergism; D008996:Monoamine Oxidase Inhibitors / Q000633:toxicity*; D011596:Psychomotor Disorders / Q000139:chemically induced; D051381:Rats; D012307:Risk Factors; D012640:Seizures / Q000139:chemically induced; D014191:Tranylcypromine / Q000633:toxicity*
D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D004050:Ditiocarb; D004221:Disulfiram