Effect of neurokinin A on human temporal muscle blood flow.
The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.
Tuxen
C
C
Department of Neurology, Gentofte Hospital, Hellerup, Denmark.
Jensen
K
K
Kjeldsen
M
M
Edvinsson
L
L
Jansen
I
I
Olesen
J
J
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008409:Mastication / Q000502:physiology; D008410:Masticatory Muscles / Q000187:drug effects*; D015288:Neurokinin A / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013703:Temporal Muscle / Q000098:blood supply / Q000187:drug effects*
D015288:Neurokinin A