title: Aplastic crisis due to human B19 parvovirus infection in red cell pyrimidine-5'-nucleotidase deficiency.
abstract: Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5'-nucleotidase (P-5'-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on the association of B19-HPV-related aplastic crisis with P-5'-N deficiency.
authors.affiliation: Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: A
authors.initials: A
authors.lastname: Vonsover
authors.forename: Y
authors.initials: Y
authors.lastname: Manor
authors.forename: F
authors.initials: F
authors.lastname: Mileguir
authors.forename: O
authors.initials: O
authors.lastname: Shpilberg
authors.forename: G
authors.initials: G
authors.lastname: Kende
authors.forename: F
authors.initials: F
authors.lastname: Brok-Simoni
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: T
authors.initials: T
authors.lastname: Gotlieb-Stematski
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
mesh_terms: D015720:5'-Nucleotidase; D000293:Adolescent; D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000201:enzymology / Q000209:etiology* / Q000382:microbiology; D004279:DNA, Viral / Q000097:blood; D004587:Electrophoresis, Agar Gel; D004912:Erythrocytes / Q000201:enzymology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D009708:Nucleotidases / Q000097:blood / Q000172:deficiency*; D010322:Parvoviridae Infections / Q000150:complications* / Q000201:enzymology / Q000382:microbiology; D014771:Virion / Q000648:ultrastructure
chemical_list: D004279:DNA, Viral; D009708:Nucleotidases; D015720:5'-Nucleotidase