[A study in the Ivory Coast (1985-1987) of the efficacy and tolerance of ivermectin (Mectizan) in human onchocerciasis. III. The tolerance and efficacy of a single oral dose of 150 mcg/kg in children].
One hundred and three male and female children of 6 to 14 years old with onchocerciasis, having or not ocular involvement and a mean skin microfilariae level of 36.1 mf/mg, received, in October 1986, a single oral dose of 150 mcg/kg ivermectin and controlled at day 4, 3 months, 6 months and 12 months post treatment. After the last control they were retreated with the same dose. The skin microfilariae count fell down to 94% of the initial level at day 4 and to 99% at 3 months. At 6 months the microfilariae count was 2% of the initial level and 5% at 12 months. The percentage of patients having microfilariae in the anterior chamber of the eye which was 33% before treatment fell down to 6% at 12 months. The percentage of patients having microfilariae in the cornea was 39% before treatment and 18% at 12 months. In the cornea and anterior chamber there was a very reduced number of microfilariae still present. 65% of the children had lesions of keratitis before treatment and 34% two months later. Adverse effects (fever, headache, pruritus, oedemas, myalgias, arthralgias) occurred in 64% of children after the first treatment and 50% after the second. They were of weak or moderate intensity and receded rapidly after administration of aspirin and/or anti-histaminic. The administration of ivermectin is an efficient and well tolerated drug in children above 5 years old.
Larivière
M
M
Faculté de Medecine Lariboisière-Saint-Louis, Laboratoire de Parasitologie-Mycologie, Paris, France.
Beauvais
B
B
Aziz
M
M
Garin
J F
JF
Peignot
C
C
Abeloos
J
J
Kouakou
P
P
Ferly-Therizol
M
M
Derouin
F
F
Sarfati
C
C
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D007560:Cote d'Ivoire; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009855:Onchocerciasis / Q000188:drug therapy*
D007559:Ivermectin
Etude en Cote-d'Ivoire (1985-1987) de l'efficacité de la tolérance de l'ivermectine (Mectizan) dans l'onchocercose humaine. III. Tolérance et efficacité d'une dose unique orale de 150 mcg/kg chez les enfants.