title: The cardiovascular effects of vecuronium during halothane anaesthesia.
abstract: In a double-blind, placebo-controlled, prospective randomized trial in 70 otherwise healthy patients undergoing elective surgery of the thyroid gland, the breast, the inguinal canal or the lower limbs, we studied the cardiovascular effects of vecuronium during halothane-nitrous oxide anaesthesia. Vecuronium was found to have no clinically significant influence on heart rate or mean arterial pressure, before or during surgery. Bradycardia was a rare event under the special conditions of the study design.
authors.affiliation: Department of Anaesthesiology, Odense University Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Kristensen
authors.forename: H S
authors.initials: HS
authors.lastname: Helbo-Hansen
authors.forename: P
authors.initials: P
authors.lastname: Toft
authors.forename: P
authors.initials: P
authors.lastname: Hole
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000139:chemically induced; D004311:Double-Blind Method; D005260:Female; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D011897:Random Allocation; D012965:Sodium Chloride; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D010919:Placebos; D012965:Sodium Chloride; D014673:Vecuronium Bromide; D006221:Halothane