[Elimination of disorders of the electrical stability of the heart in experimental myocardial infarct and postinfarct cardiosclerosis under the influence of a benzodiazepine receptor agonist].
It was shown on Wistar male rats that agonist of benzodiazepine receptors phenazepam considerably suppressed the heart ectopic activity and eliminated disturbances of the heart electric stability in acute myocardial infarction and postinfarction cardiosclerosis. The drug prevented to a considerable extent the death rate of animals within the first day following the ligation of coronary artery and the fall of arterial pressure in animals with the acute myocardial infarction. Possible mechanism of the benzodiazepine agonist effect is under discussion.
Meerson
F Z
FZ
Abdikaliev
N A
NA
Pshennikova
M G
MG
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012598:Sclerosis; D014693:Ventricular Fibrillation / Q000503:physiopathology / Q000517:prevention & control
D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents; D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C017928:phenazepam
Ustranenie narusheniĭ élektricheskoĭ stabil'nosti serdtsa pri éksperimental'nom infarkte miokarda i postinfarktnom kardioskleroze pod vliianiem agonista benzodiazepinovykh retseptorov.