[Antitumor activities of oily suspended YM881 (SMANCS) against VX2 carcinoma].
YM881 (MW 15,000) is a conjugate protein preparation of two copolymer of styrene-maleic acid [SMA] (MW 1,500) and neocarzinostatin [NCS] (MW 12,000). Antitumor activities of YM881 and NCS with or without oily solvent injected arterially against VX2 carcinoma of rabbits were examined. Based on the growth and histological examination of the tumor, remarkable anti-tumor activities were observed with oily suspended YM881 but not with the other group. This results indicate that targeting of the anticancer agent to the tumor is most important for eliciting of antitumor activities.
Kimura
M
M
Dept. of Surgery Kumamoto University Medical School.
Konno
T
T
Ohtsuka
N
N
Mizumachi
R
R
Oda
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008299:Maleic Anhydrides / Q000008:administration & dosage / Q000627:therapeutic use*; D011137:Polystyrenes / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012074:Remission Induction; D013535:Suspensions; D009353:Zinostatin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D005663:Furans; D008299:Maleic Anhydrides; D011137:Polystyrenes; D013535:Suspensions; C035755:poly(maleic acid-styrene)neocarzinostatin; D007459:Iodized Oil; D009353:Zinostatin