title: Electroencephalographic study of naloxone effects in the recovery of an acute alcoholic intoxication.
abstract: Experimental assays analysing EEG changes during the recovery of an acute alcoholic intoxication were carried out in three groups of cats: 1) Recovery of acute alcoholic intoxication produced by continuous intravenous perfusion of ethanol, 0.06 g/kg/min, during 20 minutes. 2) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), just after finishing alcohol perfusion. 3) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), 15 min after finishing perfusion. Naloxone administered after an acute alcoholic intoxication worsens the recovery of EEG parameters; 1-2 (p less than 0.05), 1-3 (p less than 0.05).
authors.affiliation: Departamento de Fisiologia Humana, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
authors.forename: M S
authors.initials: MS
authors.lastname: Dawid-Milner
authors.forename: E J
authors.initials: EJ
authors.lastname: Díaz-Calavia
authors.forename: J P
authors.initials: JP
authors.lastname: Lara
authors.forename: R
authors.initials: R
authors.lastname: Fernández del Moral
authors.forename: J
authors.initials: J
authors.lastname: Jiménez-Vargas
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002415:Cats; D004357:Drug Synergism; D004569:Electroencephalography; D004723:Endorphins / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D017450:Receptors, Opioid, mu
chemical_list: D004723:Endorphins; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; D000431:Ethanol