title: Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age).
abstract: Twenty primary endometrial carcinomas in 40 year-old or younger women were collected from a series of 845 carcinomas and newly re-evaluated. The typical histological profile was well-differentiated adenocarcinoma (30%) or adenoacanthoma (35%); however, a case of adenosquamous carcinoma and an exceptional malignant mixed mesodermal tumor were also observed. No tendency for myometrial infiltration (M0) was displayed by 11 (55%) of the cases, while 6 were M1 and 3 were M2 infiltrating neoplasias. Adenomatous hyperplasia was associated with cancer in 53% of the 15 assessable cases. Histopathological diagnostic problems were elicited in 5 cases only. Typical Stein-Leventhal syndrome occurred in 7 patients (35%), while polycystic ovaries were observed in 15 cases (75%). Usually, the patients were obese (40%) and nulligravida (65%). All but one case were stage I disease. Prognosis seems to be excellent following surgery.
authors.affiliation: Department of Pathology, University of Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colafranceschi
authors.forename: G L
authors.initials: GL
authors.lastname: Taddei
authors.forename: G
authors.initials: G
authors.lastname: Scarselli
authors.forename: F
authors.initials: F
authors.lastname: Branconi
authors.forename: G
authors.initials: G
authors.lastname: Tinacci
authors.forename: L
authors.initials: L
authors.lastname: Savino
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology*; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology*