The relationship of deoxyribonucleic acid content to conventional prognostic factors in Wilms tumor.
Deoxyribonucleic acid ploidy as determined by flow cytometric analysis was compared to histological findings and tumor stage for accuracy of prediction of patient survival in a series of Wilms tumors. While anaplastic tumors were more likely aneuploid or tetraploid than diploid, no statistically significant relationship was found between deoxyribonucleic acid ploidy and patient survival in our series. Tumor histology and stage as defined by the National Wilms Tumor Study were more accurate predictors of patient survival than deoxyribonucleic acid ploidy.
Layfield
L J
LJ
Department of Pathology, UCLA School of Medicine 90024.
Ritchie
A W
AW
Ehrlich
R
R
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D009396:Wilms Tumor / Q000235:genetics* / Q000401:mortality
D004273:DNA, Neoplasm