Immunopathology of chronic progressive hepatitis in nude mice infected with low-virulent mouse hepatitis virus.
Progressive hepatitis in athymic nude (nu/nu) mice due to a low-virulent mouse hepatitis virus, MHV-2 cc, was examined for involvement of immunocytes and serum antibodies. At 3 to 6 weeks postinoculation (p.i.) a considerable number of Mac 1- and asialo GM1-positive cells were accumulated in the affected liver and spleen. There were also some Thy-1-positive cells. Later than 2 weeks p.i., serum IgG and IgM antibodies were detected in parallel with virus-neutralizing activity, while the IgG levels were lower than those of infected euthymic (nu/+) littermates. By transfer of the infected nu/nu mouse serum, the recipient euthymic mice acquired resistance to lethal challenge infection with a virulent virus, MHV-2.
Midoro
K
K
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo.
Nakanaga
K
K
Kyuwa
S
S
Fujiwara
K
K
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology; D007106:Immune Sera; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000235:genetics / Q000472:pathogenicity; D009154:Mutation; D013154:Spleen / Q000276:immunology / Q000473:pathology; D014774:Virulence
D000914:Antibodies, Viral; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M