[Localization of human lung cancer xenografts in nude mice using monoclonal antibody].
Radiolabeled monoclonal antibodies to human lung cancer were injected into nude mice bearing xenografts; and the biodistribution and tumor localization were studied. Xenografts were able to concentrate radioiodinated McAb. Radioactivities of tumor which were 5.09, 5.79 and 7.57% dose/g respectively 3-5 days after injection were higher than those of blood or organ. Tumor/blood ratios were 1.82-2.36 whereas tumor/organ ratios were more than 2. The localization indices of two McAbs were 3.4-5.6 and less than 1.5 in normal organs. The xenografts were visualized after injection of radiolabeled McAbs. These results have shown that anti-human lung cancer McAbs can specifically localize on xenografts in nude mice and it is possible to use them clinically for imaging of lung cancer.
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D000230:Adenocarcinoma / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology; D015902:Gamma Cameras; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm