title: Noninfectious rotavirus (strain RRV) induces an immune response in mice which protects against rotavirus challenge.
abstract: We found that female adult mice parenterally inoculated with noninfectious rotavirus (simian strain RRV) developed virus-specific neutralizing antibodies in the serum; newborn mice from these dams were protected against RRV-induced gastroenteritis. In addition, mice parenterally inoculated with noninfectious RRV developed virus-specific cytotoxic T-lymphocyte precursors in the spleen. Replication of rotavirus in intestinal epithelial cells was apparently not required to induce rotavirus-neutralizing antibodies or rotavirus-specific cytotoxic T lymphocytes. Parenteral immunization of infants and young children with noninfectious rotaviruses may induce an immune response which protects against rotavirus challenge.
authors.affiliation: Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania 19104.
authors.forename: P A
authors.initials: PA
authors.lastname: Offit
authors.forename: K I
authors.initials: KI
authors.lastname: Dudzik
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002460:Cell Line; D003967:Diarrhea / Q000517:prevention & control; D005260:Female; D005759:Gastroenteritis / Q000517:prevention & control*; D007112:Immunity, Maternally-Acquired; D051379:Mice; D008810:Mice, Inbred C57BL; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000517:prevention & control*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines