title: Absence of a single repeat from the coding region of the human involucrin gene leading to RFLP.
abstract: The human involucrin gene has been mapped to the region q21-q22 of chromosome 1. Three of six Utah families examined were polymorphic for a PstI fragment of the involucrin gene. In one individual, the variant PstI fragment was found by DNA sequencing to be missing one of the 39 repeats that make up two-thirds of the coding region.
authors.affiliation: Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA 02115.
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Phillips
authors.forename: H
authors.initials: H
authors.lastname: Green
authors.forename: H
authors.initials: H
authors.lastname: Stroh
authors.forename: K
authors.initials: K
authors.lastname: Glatt
authors.forename: G
authors.initials: G
authors.lastname: Burns
authors.forename: S A
authors.initials: SA
authors.lastname: Latt
mesh_terms: D000483:Alleles; D000818:Animals; D002878:Chromosomes, Human, Pair 1; D003062:Codon; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D011498:Protein Precursors / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping
chemical_list: D003062:Codon; D011498:Protein Precursors; C032253:involucrin