title: Calcium channels in undifferentiated PC12 rat pheochromocytoma cells.
abstract: Undifferentiated rat pheochromocytoma PC12 cells were voltage clamped using the whole cell technique. After blockade of outward currents, calcium currents were elicited from -40 and -100 mV. A subpopulation of cells displayed only one current component activated at -10 mV and slowly decaying. In other cells this current coexisted with a component activated around -40 mV and decaying with a faster time constant. We conclude that undifferentiated PC12 cells can express two types of calcium channels, L (long-lasting) and N (neuronal)-type channels.
authors.affiliation: Department of Pharmacology, S. Raffaele Scientific Institute, University of Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Janigro
authors.forename: G
authors.initials: G
authors.lastname: Maccaferri
authors.forename: J
authors.initials: J
authors.lastname: Meldolesi
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000503:physiopathology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002460:Cell Line; D004553:Electric Conductivity; D008564:Membrane Potentials; D008978:Mollusk Venoms / Q000494:pharmacology; D009568:Nitrendipine / Q000494:pharmacology; D010673:Pheochromocytoma / Q000503:physiopathology*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000502:physiology*; D020960:omega-Conotoxins
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008978:Mollusk Venoms; D020960:omega-Conotoxins; C053423:Conus magus toxin; D009568:Nitrendipine