title: [Pineal metastatic tumor from lung cancer initially caused by neurological abnormalities of pineal body tumor].
abstract: A rare case is reported of pineal metastasis from lung cancer initially caused by neurological abnormalities of pineal tumor. A 70-year-old female suffering from headache and deterioration of consciousness for 1 week was admitted. She also had a tumor on both sides of her neck. On admission, neurological examination revealed disturbance of upward gaze, and CT scans showed hydrocephalus and pineal tumor. The tumor was seen as a slightly high density mass on non-contrast CT, and was homogeneously enhanced after administration of contrast material. Right V-P shunt and excision of the left neck tumor were performed at the same time. Pathological diagnosis of neck tumor was undifferentiated carcinoma metastasized to cervical lymph nodes. Extensive study was made, by bronchial fiberscope and biopsy, in order to find the origin of the malignancy and disclosed a small cell lung cancer of left lower lobe. The patient took radiation therapy for both the whole brain (60 Gy) and for the bilateral cervical regions (45 Gy). Two courses of chemotherapy using CDDP, ADR, VCR and CY were administered. Both the neck and the pineal tumors were markedly reduced in size at the termination of radiation therapy. However, she was readmitted 3 months later because of dyspnea. Chest X-P revealed enlargement of the left-lung tumor. She died on April 22, 1987. General autopsy disclosed invasive enlargement of left lung cancer, however, no remote metastasis was found. Examination of pineal region showed only necrotic pineal tissue, and no tumor cell was seen in either macroscopic or microscopic study.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurosurgery, Tenri Hospital, Nara, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Keyaki
authors.forename: Y
authors.initials: Y
authors.lastname: Makita
authors.forename: S
authors.initials: S
authors.lastname: Nabeshima
authors.forename: T
authors.initials: T
authors.lastname: Tei
authors.forename: J
authors.initials: J
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Nioka
authors.forename: Y
authors.initials: Y
authors.lastname: Nambu
authors.forename: H
authors.initials: H
authors.lastname: Kitamura
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009333:Neck; D009422:Nervous System Diseases / Q000209:etiology*; D010870:Pineal Gland