title: Stannous chloride-induced increase in calcium entry into motor nerve terminals of the frog.
abstract: The effects of SnCl2 on potentials recorded extracellularly from motor nerve terminals of the bullfrog were studied to elucidate the mechanism of the SnCl2-induced facilitation of evoked transmitter release. Under conditions in which the muscle preparations were pretreated with d-tubocurarine and tetraethylammonium in a K+-free medium, SnCl2 (50 microM) augmented the prolonged positive deflection ascribed to the inward Ca2+ current, an effect which was reduced by addition of Cd2+. The results suggest that SnCl2 could increase Ca2+ entry into the nerve terminals.
authors.affiliation: Department of Dental Pharmacology, Matsumoto Dental College, Shiojiri, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Maehashi
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects; D011892:Rana catesbeiana; D014001:Tin / Q000494:pharmacology*; D017971:Tin Compounds; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D018377:Neurotransmitter Agents; D015221:Potassium Channels; D017971:Tin Compounds; C023599:stannous chloride; D014001:Tin; D002118:Calcium; D014403:Tubocurarine