title: Lymphoepithelioma-like carcinoma of the lung.
abstract: Originally described in the nasopharynx, lymphoepitheliomas are undifferentiated carcinomas with prominent lymphoid infiltration. Recently this tumor has been described in a number of other sites. An association with prior infection by the Epstein-Barr virus has been recognized in cases from the nasopharynx. We report four cases of lymphoepithelioma-like carcinoma arising in the lung. Epstein-Barr virus serology indicated prior infection in two cases, one of which was also found by in situ hybridization to have the virus genome. Lymphoepithelioma-like carcinoma must be considered in the differential diagnosis of primary lung tumors, particularly when an extensive infiltrate by lymphoid tissue is present and may even suggest lymphoma.
authors.affiliation: Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: A E
authors.initials: AE
authors.lastname: Butler
authors.forename: T V
authors.initials: TV
authors.lastname: Colby
authors.forename: L
authors.initials: L
authors.lastname: Weiss
authors.forename: C
authors.initials: C
authors.lastname: Lombard
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000382:microbiology; D003593:Cytoplasm / Q000648:ultrastructure; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization
chemical_list: D004279:DNA, Viral