New evidence that L-glutamate is a transmitter at the squid giant synapse.
Experiments are described showing unequivocally that transmission at the squid giant synapse can be reversibly blocked by L-glutamate and its agonists kainate, quisqualate and AMPA, though not by NMDA. This effect is presumably brought about by desensitization. The glutamate antagonists cis-2,3-PDA, GAMS and the new quinoxalinediones CNQX and DNQX are also potent reversible blockers. These findings provide new evidence that L-glutamate is a transmitter at the giant synapse and further suggest that the glutamate receptor may be of the non-NMDA type.
De Santis
A
A
Stazione Zoologica, Naples, Italy.
Messenger
J B
JB
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D049832:Decapodiformes / Q000502:physiology*; D005971:Glutamates / Q000502:physiology*; D066298:In Vitro Techniques; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000378:metabolism; D013569:Synapses / Q000502:physiology*
D005971:Glutamates; D018377:Neurotransmitter Agents