Teratogenicity of combinations of sodium dichromate, sodium arsenate and copper sulphate in the rat.
1. The teratogenicity of sodium dichromate (2 mg Cr/kg), sodium arsenate (5 mg As/kg) and copper sulphate (2 mg Cu/kg) in female Wistar rats was studied following the administration of the test compounds separately and in their various combinations on gestation day 8. 2. The test compounds administered separately and the combination of dichromate plus Cu2+ were non-fetotoxic and either non- or weakly teratogenic, whereas arsenate/Cu2+ was both weakly fetotoxic and teratogenic. 3. Dichromate/arsenate and dichromate/arsenate/Cu2+ caused a marked decrease in mean fetal weight and an increased incidence of fetal resorption and abnormality formation.
Mason
R W
RW
Toxicology Research Unit (Medical Research Council of New Zealand) University of Otago Medical School, Dunedin.
Edwards
I R
IR
Fisher
L C
LC
D000818:Animals; D001149:Arsenates / Q000008:administration & dosage / Q000633:toxicity*; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002840:Chromates / Q000008:administration & dosage / Q000633:toxicity*; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D019327:Copper Sulfate; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens / Q000008:administration & dosage*
D001149:Arsenates; D002840:Chromates; D013723:Teratogens; D003300:Copper; C009277:sodium arsenate; C016104:sodium bichromate; D019327:Copper Sulfate; D001151:Arsenic