title: [Vecuronium in dystrophia myotonica (Curschmann-Steinert)].
abstract: An emergency laparotomy was performed in a 31-year-old female (body wt 48 kg) with known myotonic dystrophy. Premedication with dantrolene (1 mg/kg i.v.) was used to prevent a myotonic response. Muscle relaxation was monitored electromyographically. Following induction with fentanyl (0.3 mg) and thiopental (200 mg), muscle relaxation was achieved with 2 mg vecuronium titrated for about 3 min until the T1-response was reduced to 10%. The recovery time was normal. A repetitive dose of 0.5 mg vecuronium was necessary after 20 min, when the T1 reached 60%. Extubation and the early postoperative period were uneventful. Because of the unknown predisposition of our patient for the development of malignant hyperthermia, anesthesia was performed with trigger-free anesthetics.
authors.affiliation: Zentrum für Anaesthesiologie, Oststadtkrankenhaus, Medizinische Hochschule Hannover.
authors.forename: G
authors.initials: G
authors.lastname: Wruck
authors.forename: M
authors.initials: M
authors.lastname: Tryba
mesh_terms: D000328:Adult; D003620:Dantrolene; D005260:Female; D006801:Humans; D007813:Laparotomy; D009223:Myotonic Dystrophy / Q000235:genetics* / Q000601:surgery; D011229:Preanesthetic Medication; D014673:Vecuronium Bromide / Q000008:administration & dosage*
chemical_list: D014673:Vecuronium Bromide; D003620:Dantrolene
vernacular_title: Vecuronium bei Dystrophia myotonica (Curschmann-Steinert).