title: Acute toxicity of combinations of sodium dichromate, sodium arsenate and copper sulphate in the rat.
abstract: 1. The intraperitoneal treatment of adult male Wistar rats with various combinations of low doses of sodium dichromate (5 mg/kg), sodium arsenate (25 mg/kg) and copper sulphate (5.9 mg/kg) tended to counteract the inherent acute toxicity of each compound. 2. The co-administration of low doses of one or more of the test compounds with a high dose of sodium dichromate (35 mg/kg), sodium arsenate (90 mg/kg) or copper sulphate (23.5 mg/kg) resulted in a significant increase in acute toxicity in comparison with that produced by the administration of high doses of dichromate, arsenate or Cu2+ alone.
authors.affiliation: Toxicology Research Unit (Medical Research Council of New Zealand), University of Otago Medical School, Dunedin.
authors.forename: R W
authors.initials: RW
authors.lastname: Mason
authors.forename: I R
authors.initials: IR
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001149:Arsenates / Q000008:administration & dosage / Q000633:toxicity*; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002840:Chromates / Q000008:administration & dosage / Q000633:toxicity*; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D019327:Copper Sulfate; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001149:Arsenates; D002840:Chromates; D003300:Copper; C009277:sodium arsenate; D003404:Creatinine; C016104:sodium bichromate; D019327:Copper Sulfate; D001151:Arsenic