Is postburn dermal ischaemia enhanced by oxygen free radicals?
The accumulated data suggest that oxygen free radicals are actively involved in the pathophysiology of the wound healing process. Since OH. and O2- directly correlate with the release of arachidonic acid and catalyse some of the enzymes participating in its cascade, their involvement in the enhancement of dermal ischaemia in the stasis zone is postulated. Experimental data using topically applied scavengers of superoxide have shown their beneficial effects on the burn wound healing process.
Kaufman
T
T
Department of Plastic Surgery, Hadassah University Hospital, Jerusalem, Israel.
Neuman
R A
RA
Weinberg
A
A
D002056:Burns / Q000503:physiopathology*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007511:Ischemia / Q000503:physiopathology*; D008054:Lipid Peroxides / Q000378:metabolism; D010101:Oxygen Consumption; D012867:Skin / Q000098:blood supply*; D014945:Wound Healing / Q000502:physiology
D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide