[Atherogenic properties of beta adrenergic blockaders evident on vascular wall cells].
In cultured human cells, beta-adrenoblockers such as propranolol, alprenolol, metoprolol, atenolol, pindolol, and thymolol, as well as sera from patients with coronary heart disease were examined for atherogenic activity following a single administration of propranolol (80 mg) and pindolol (10 mg). Addition of the beta-adrenoblockers to the cell culture was demonstrated to enhance cellular total cholesterol levels and to stimulation their proliferation. Propranolol and pindolol given in a single dose was found to result in the appearance of atherogenic properties of the patients' sera.
Orekhov
A N
AN
Kozlov
S G
SG
Baldenkov
G N
GN
Tertov
V V
VV
Khashimov
K H
KH
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D001011:Aorta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001018:Aortic Diseases / Q000139:chemically induced*; D001161:Arteriosclerosis / Q000139:chemically induced*; D002784:Cholesterol / Q000378:metabolism*; D003470:Culture Media; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D013268:Stimulation, Chemical
D000319:Adrenergic beta-Antagonists; D003470:Culture Media; D002784:Cholesterol
Aterogennye svoĭstva beta-adrenoblokatorov, proiavliaemye na kletkakh sosudistoĭ stenki.