title: Transient forebrain ischemia produces multiple deficits in dopamine D1 transmission in the lateral neostriatum of the rat.
abstract: Striatal dopamine D1 transmission was studied in rats 7 days after transient (30 min) forebrain ischemia using the 4-vessel occlusion model. The striatal distribution of dopamine D1 ([3H]SCH 23390 binding sites) and D2 ([3H]sulpiride binding sites) receptors as well as the distribution of adenylate cyclase ( [3H]forskolin binding sites) and of the intracytoplasmic dopamine and cAMP-regulated phosphoprotein DARPP-32 related to D1 transmission were analyzed. While the distribution of D2 receptors was unaffected 7 days after the ischemic insult, all the other markers showed a patchy disappearance in the dorsolateral part of the neostriatum. These findings underline the existence of selective multiple deficits in D1 transmission after transient forebrain ischemia in rat striatum.
authors.affiliation: Institute of Human Physiology, University of Modena, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Benfenati
authors.forename: E M
authors.initials: EM
authors.lastname: Pich
authors.forename: R
authors.initials: R
authors.lastname: Grimaldi
authors.forename: M
authors.initials: M
authors.lastname: Zoli
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: G
authors.initials: G
authors.lastname: Toffano
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
mesh_terms: D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000378:metabolism; D001665:Binding Sites; D002545:Brain Ischemia / Q000378:metabolism*; D005576:Colforsin / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004027:Diencephalon / Q000098:blood supply; D018492:Dopamine Antagonists; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D013469:Sulpiride / Q000378:metabolism; D009435:Synaptic Transmission; D013687:Telencephalon / Q000098:blood supply
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D005576:Colforsin; D013469:Sulpiride