title: Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia.
abstract: Sulfasalazine, a commonly prescribed drug for the treatment of inflammatory bowel disease, can cause an allergic reaction with hepatotoxicity, lymphadenopathy, and rash. In addition, many hematologic complications have been observed with sulfasalazine, including aplastic anemia, thrombocytopenia, and erythroid hypoplasia. However, thrombocytopenia in association with sulfasalazine hypersensitivity has not been previously reported. We report a child who developed severe thrombocytopenia and anemia during a hypersensitivity reaction to sulfasalazine.
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati, Ohio 45229.
authors.forename: D A
authors.initials: DA
authors.lastname: Gremse
authors.forename: J
authors.initials: J
authors.lastname: Bancroft
authors.forename: M S
authors.initials: MS
authors.lastname: Moyer
mesh_terms: D000740:Anemia / Q000139:chemically induced; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D008297:Male; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D012460:Sulfasalazine