title: The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression.
abstract: The homeotic gene Sex Combs Reduced (Scr) of Drosophila is required during embryogenesis for labial and first thoracic segment development. We define the Scr gene structure, showing that the major embryonic transcript is proximal to the fushi tarazu gene, and report the sequence of the transcript, which encodes a 413-amino acid, homeodomain-containing protein. We describe Scr protein distribution throughout embryogenesis. Expression begins at gastrulation and is eventually apparent in three tissues, epidermis, nervous system and visceral mesoderm, though there are clear contrasts in the domains of expression in these three tissues.
authors.affiliation: Biozentrum, University of Basel, Switzerland.
authors.forename: P K
authors.initials: PK
authors.lastname: LeMotte
authors.forename: A
authors.initials: A
authors.lastname: Kuroiwa
authors.forename: L I
authors.initials: LI
authors.lastname: Fessler
authors.forename: W J
authors.initials: WJ
authors.lastname: Gehring
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000033:anatomy & histology; D004817:Epidermis / Q000032:analysis; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D007301:Insect Hormones / Q000235:genetics* / Q000502:physiology; D008648:Mesoderm / Q000032:analysis; D008969:Molecular Sequence Data; D009420:Nervous System / Q000032:analysis / Q000196:embryology; D011993:Recombinant Fusion Proteins / Q000276:immunology; D014157:Transcription Factors
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D011993:Recombinant Fusion Proteins; C059627:Scr protein, Drosophila; D014157:Transcription Factors