title: Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs.
abstract: Treatment of healthy dogs with the butyrophenone derivative, lenperone hydrochloride, at two different doses significantly decreased gastroesophageal sphincter pressure (GESP). No dose-related effect was identified. Individual variation in the response to lenperone hydrochloride was noted which was consistent on a day-to-day basis. Lenperone hydrochloride is unsuitable for chemical restraint of dogs undergoing esophageal manometry because it decreases GESP and because the magnitude of the decrease varies considerably between dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
authors.forename: S E
authors.initials: SE
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Zelner
authors.forename: R G
authors.initials: RG
authors.lastname: Sherding
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002090:Butyrophenones / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011312:Pressure
chemical_list: D014150:Antipsychotic Agents; D002090:Butyrophenones; C100204:lenperone