title: [The behavior of serum "liver enzyme" activity in children with chronic renal failure, hemodialysis and kidney transplantation].
abstract: Liver enzymes were measured in 24 children with different degrees of renal insufficiency, in 6 children treated by chronic hemodialysis and in 13 children after kidney transplantation. The hemodialyzed and transplanted patients have the highest ALAT activity, independently of the presence of a liver infection. The AP activity in these patient groups were not different from the reference value. The activity of ALAT, GGT and CHE, respectively were most pathologic in the hemodialysis group. The enzyme activities have not been influenced by a single dialysis and a 6-month dialysis course. In uremic and chronic hemodialyzed patients the enzyme combination of ALAT, GGT and CHE has been recommended in the diagnosis and follow-up control of a liver cell damage. In the evaluation of enzyme activities in comparison with reference values of healthy volunteers an enzyme inhibition by the uremic serum should considered.
authors.affiliation: Klinik und Poliklinik für Kinderheilkunde Bereiches Medizin (Charité) Humboldt-Universität zu Berlin.
authors.forename: U
authors.initials: U
authors.lastname: Otting
authors.forename: C
authors.initials: C
authors.lastname: Hellmann
authors.forename: S
authors.initials: S
authors.lastname: Gellert
authors.forename: S
authors.initials: S
authors.lastname: Devaux
authors.forename: P
authors.initials: P
authors.lastname: Grossmann
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D002648:Child; D002802:Cholinesterases / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005969:Glutamate Dehydrogenase / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D006435:Renal Dialysis; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D002802:Cholinesterases; D000469:Alkaline Phosphatase
vernacular_title: Zum Aktivitätsverhalten von "Leberenzymen" im Serum bei chronisch niereninsuffizienten, hämodialysierten und nierentransplantierten Kindern.