title: [Vaccinia and ectromelia recombinant viruses, causing an infection, characteristic for ectromelia, in mice].
abstract: Ten recombinants between the viruses of vaccinia and ectromelia were isolated that cause the ectromelia virus specific lesions in mice. The structure of recombinant viral genomes, the efficiency of viral propagation in mice, the nature of lesions induced by viruses have been studied. Eight of obtained recombinants have a DNA insertion originating from the right end of ectromelia viral genome, nine recombinants have an insertion originating from the left end, seven recombinants possess both insertions. The latter recombinants have more pronounced pathogenicity for mice. Both revealed regions are supposed to define the specific pathogenicity of ectromelia virus for mice.
authors.forename: T G
authors.initials: TG
authors.lastname: Senkevich
authors.forename: R R
authors.initials: RR
authors.lastname: Araslanov
authors.forename: T S
authors.initials: TS
authors.lastname: Vovk
authors.forename: V N
authors.initials: VN
authors.lastname: Loparev
authors.forename: V I
authors.initials: VI
authors.lastname: Chernos
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004279:DNA, Viral / Q000235:genetics; D004481:Ectromelia virus / Q000235:genetics* / Q000472:pathogenicity; D004482:Ectromelia, Infectious / Q000235:genetics*; D005814:Genes, Viral; D051379:Mice; D011995:Recombination, Genetic; D015183:Restriction Mapping; D014616:Vaccinia virus / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D004251:DNA Transposable Elements; D004279:DNA, Viral
vernacular_title: Rekombinanty virusov ospovaktsiny i éktromelii, vyzyvaiushchie kharakternye dlia virusa éktromelii porazheniia u mysheĭ.