title: The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma.
abstract: In lymphoid neoplasms, nonrandom cytogenetic abnormalities correlate with clinical, morphologic and immunophenotypic features. A subtype of non-Hodgkin's lymphoma, which expresses the Ki-1 antigen (CD30) and has distinct morphologic and clinical features, has recently been described. We now report the association of a reciprocal translocation involving the short arm of chromosome 2 (band p23) and the long arm of chromosome 5 (band q35), t(2;5)(p23;q35), with Ki-1 positive anaplastic large cell lymphoma. Rearrangement of the genes that are located at the breakpoints on chromosomes 2 and 5 may be a critical step in the pathogenesis of this lymphoma.
authors.affiliation: Department of Medicine, University of Chicago, Illinois 60637.
authors.forename: M M
authors.initials: MM
authors.lastname: Le Beau
authors.forename: M A
authors.initials: MA
authors.lastname: Bitter
authors.forename: R A
authors.initials: RA
authors.lastname: Larson
authors.forename: L A
authors.initials: LA
authors.lastname: Doane
authors.forename: E D
authors.initials: ED
authors.lastname: Ellis
authors.forename: W A
authors.initials: WA
authors.lastname: Franklin
authors.forename: C M
authors.initials: CM
authors.lastname: Rubin
authors.forename: M E
authors.initials: ME
authors.lastname: Kadin
authors.forename: J W
authors.initials: JW
authors.lastname: Vardiman
mesh_terms: D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017730:Ki-1 Antigen; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic
chemical_list: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen