In vivo studies with dimethyldithiocarbamate, a possible new antimicrobial for use against Aspergillus fumigatus in poultry.
Dimethyldithiocarbamate (DmDTC), the carbamate analogue, was tested for therapeutic efficacy in a series of in vivo challenge trials using 5- and 10-week-old white leghorn chickens. Challenge organisms were Pasteurella multocida X-73, Escherichia coli O1:K1, and Aspergillus fumigatus. Birds were evaluated for survival rates, lesion scores, and the rate at which the bacteria or mold could be reisolated following challenge. Results showed DmDTC to be ineffective against P. multocida and E. coli at the treatment levels and in the form used in these trials, but DmDTC significantly reduced lesion scores and inhibited the rate of isolation of A. fumigatus compared with untreated infected birds.
Delap
S K
SK
Hudson Foods, Inc., Rogers, Arkansas 72756.
Skeeles
J K
JK
Beasley
J N
JN
Kreider
D L
DL
Whitfill
C E
CE
Houghten
G E
GE
Walker
E M
EM
Cannon
D J
DJ
Earls
P L
PL
D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D002645:Chickens / Q000382:microbiology*; D004125:Dimethyldithiocarbamate / Q000627:therapeutic use*; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary; D010325:Pasteurella / Q000302:isolation & purification; D010326:Pasteurella Infections / Q000188:drug therapy / Q000662:veterinary; D011201:Poultry Diseases / Q000188:drug therapy*; D013859:Thiocarbamates / Q000627:therapeutic use*
D004125:Dimethyldithiocarbamate; D013859:Thiocarbamates