Generation and characterization of a human monoclonal antibody against phenolic glycolipid-I of M. leprae.
The development of an Epstein-Barr virus transformed human B-cell line secreting a monoclonal antibody (MoAb), KR2/B5 is described. KR2/B5 is an IgM type of antibody and is highly specific for phenolic glycolipid-I (PGL-I) a component unique to M. leprae. The MoAb appears to be directed against the terminal sugar residue of the immunodominant trisaccharide component of PGL-I.
Moudgil
K D
KD
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Gupta
S K
SK
Talwar
G P
GP
D000911:Antibodies, Monoclonal / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D002472:Cell Transformation, Viral; D006017:Glycolipids / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007918:Leprosy / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae