Pathological findings of two types of lymphoid malignancy in sheep inoculated with bovine leukemia virus.
Different types of lymphoid malignancy were observed in two sheep inoculated with BLV-containing materials. Sheep 1 showed severe leukemic change in the peripheral blood and splenomegaly but lymphosarcoma in the lymph nodes was absent. Sheep 2 had lymphosarcoma in the lymph nodes and various organs. Neoplastic cells had B-cell marker in both cases and a few neoplastic cells contained intracytoplasmic IgM in sheep 2. It was presumed that B-cells might be transformed into neoplastic cells on the way of their differentiation. Some of neoplastic cells might have ability of immunoglobulin-production in sheep 2.
Ishino
S
S
Matsuda
I
I
Yamamoto
H
H
Yoshino
T
T
Sentsui
H
H
Mizuno
Y
Y
Kono
Y
Y
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D007075:Immunoglobulin M / Q000096:biosynthesis; D001909:Leukemia Virus, Bovine; D007942:Leukemia, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D012756:Sheep
D007075:Immunoglobulin M