Somatostatin inhibits the effect of secretin on bile flow and on hepatic bilirubin transport in the rat.
Increasing amounts of porcine secretion (0.05 to 2.00 clinical units/h/100 g body wt) given to rats during a continuous infusion of bilirubin, increased bile flow and the apparent maximal biliary excretion of bilirubin ('Tm'). This increment was caused by an enhanced biliary output of bilirubin monoconjugates. The effect was dose dependent but maximal at a secretin infusion of 0.80 CU. Somatostatin 0.2 and 0.8 microgram/h/100 g body wt caused a dose related inhibition of the hepatic effects of secretin both on bile flow and on biliary output of bilirubin conjugates. As secretin elicits the release of somatostatin, a feed-back system could be envisaged whereby the somatostatin released stops the effects of secretin.
Ricci
G L
GL
Department of Medical Research, Catholic University of Leuven, Belgium.
Fevery
J
J
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000493:pharmacokinetics*; D001692:Biological Transport / Q000187:drug effects; D002756:Cholagogues and Choleretics / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012633:Secretin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*
D002756:Cholagogues and Choleretics; D012633:Secretin; D013004:Somatostatin; D001663:Bilirubin