title: The role of excitatory amino acids in synaptic transmission in the hippocampus.
abstract: We have highlighted some aspects of the action of excitatory amino acid transmission in the hippocampus. Fast epsps can be blocked by CNQX to reveal a component of synaptic transmission which is mediated by NMDA receptors. Extracellular recordings of ionic activities show that NMDA and non-NMDA ionophores are permeable to the major monovalent cations, while NMDA ionophores also appear to be permeable to Ca2+. Interactions of agonists applied by iontophoresis may be correlates of phenomena such as LTP, which can be evoked by appropriate synaptic stimulation.
authors.affiliation: Institute of Physiology, Universitetsparken, University of Aarhus, Denmark.
authors.forename: J D
authors.initials: JD
authors.lastname: Lambert
authors.forename: R S
authors.initials: RS
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Andreasen
authors.forename: M S
authors.initials: MS
authors.lastname: Jensen
authors.forename: U
authors.initials: U
authors.lastname: Heinemann
mesh_terms: D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D007477:Ions; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D000596:Amino Acids; D007477:Ions; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface