title: Amygdaloid kindling of rats increases preprosomatostatin mRNA and somatostatin without affecting glutamic acid decarboxylase (GAD) mRNA or GAD.
abstract: The levels of preprosomatostatin (preproSS) mRNA, somatostatin-like immunoactivity (SS-LI) (also known as somatotropin-release inhibitory factor, or SRIF), glutamic acid decarboxylase (GAD) activity and GAD mRNA were determined in several brain regions of amygdaloid-kindled rats. SS mRNA and SS increased in the cortex and striatum, while only SS increased in the hippocampus. No changes were detected in either GAD activity or GAD mRNA in any brain region. The data suggest that somatostatin may be one of the factors involved in the chain of events leading to kindled seizures.
authors.affiliation: Clinical Neuroscience Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
authors.forename: H
authors.initials: H
authors.lastname: Shinoda
authors.forename: J P
authors.initials: JP
authors.lastname: Schwartz
authors.forename: N S
authors.initials: NS
authors.lastname: Nadi
mesh_terms: D000679:Amygdala / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D005786:Gene Expression Regulation; D005968:Glutamate Decarboxylase / Q000235:genetics* / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000235:genetics* / Q000378:metabolism
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; D013004:Somatostatin; D005968:Glutamate Decarboxylase