Plasma somatostatin activity in medullary cancer of the thyroid.
In a group consisting of 50 adults and 5 children with diagnosed or suspected medullary cancer of the thyroid, plasma somatostatin levels were measured in 77 samples with a sensitive radioimmunoassay. Only 2 patients had clearly enhanced plasma somatostatin immunoreactivity, both with highly active aggressive tumors. Other patients had plasma somatostatin levels of under 20 ng/l or undetectable ones. No evidence of response of somatostatin levels to pentagastrin stimulation was found.
Neradilová
M
M
Research Institute of Endocrinology, Faculty Hospital, Prague, Czechoslovakia.
Nĕmec
J
J
Zamrazil
V
V
Bednár
J
J
Pechová
M
M
Soutorová
M
M
D000293:Adolescent; D000328:Adult; D002116:Calcitonin / Q000097:blood; D002277:Carcinoma / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000378:metabolism; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood*
D013004:Somatostatin; D002116:Calcitonin; D010418:Pentagastrin