title: [Retinoic acid modification of cell culture used for reproduction of enteropathogenic viruses].
abstract: The 0.001-0.005% retinoic acid injection into the growth cultural medium of prime and continue cell cultures 12-24h before inoculation considerably raised the cell sensitivity to animal entero- and coronaviruses. The entero- and coronaviruses concentrations in cultural medium increased by 10(1.58) and 10(1.68)TCID 50/1.0 respectively. The optimized parameters of the cell culture processing for the enteropathogenic viruses reproduction improvement are proposed.
authors.forename: V N
authors.initials: VN
authors.lastname: Tatskaia
authors.forename: V I
authors.initials: VI
authors.lastname: Nozdrin
authors.forename: V G
authors.initials: VG
authors.lastname: Kvachev
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003332:Coronaviridae / Q000254:growth & development*; D003470:Culture Media; D004770:Enterovirus / Q000254:growth & development*; D004771:Enteroviruses, Porcine / Q000254:growth & development*; D013552:Swine; D013997:Time Factors; D005760:Transmissible gastroenteritis virus / Q000254:growth & development*; D014212:Tretinoin / Q000494:pharmacology*; D014776:Virus Cultivation
chemical_list: D003470:Culture Media; D014212:Tretinoin
vernacular_title: Modifikatsiia retinoevoĭ kislotoĭ kul'tury kletok, ispol'zuemoĭ dlia reproduktsii énteropatogennykh virusov.