Effect of TSAA-291 on male reproductive tract and fertility of the rat.
Adult male rats were injected with TSAA-291 (16 beta-ethyl-17 beta-hydroxyestr-4-en-3-one), a steroidal antiandrogen, daily for 30 days at two doses, viz., 10.0 and 25.0 mg/kg. The treatment caused a dose-dependent reduction in the weights of testis, epididymis, and other accessory sex glands. In the animals that received the high dose, 50% of the rats showed spermatogenic arrest in about 20% of the seminiferous tubules and Leydig cell morphology was normal. The levels of glycerylphosphorylcholine and sialic acid were significantly reduced in the cauda epididymis of all the treated rats. There was a reduction in the number of motile spermatozoa in the cauda epididymis of rats treated with high dose of the antiandrogen. This was accompanied by a reduced number of females exhibiting spermatozoa in their vaginal smears. A combination treatment of the antiandrogen and androgen appears to be a promising approach for fertility regulation in the male.
Srivastava
A
A
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Maikhuri
J P
JP
Setty
B S
BS
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D005298:Fertility / Q000187:drug effects; D005632:Fructose / Q000378:metabolism; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D008297:Male; D019158:N-Acetylneuraminic Acid; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism
D000726:Androgen Antagonists; D012794:Sialic Acids; D005632:Fructose; D005997:Glycerylphosphorylcholine; D009277:Nandrolone; D019158:N-Acetylneuraminic Acid; C005671:oxendolone