Linearity of the accumulation of various dosages of uranium in the major organs of mature male Japanese quail. Effect of various doses of estradiol-17 beta.
1. Male Japanese quail were given 2.20 x 10(-4)-14.53 mg uranium/kg intravenously as uranyl ion (235U label). 2. The relationship between dosage and the 18-hr accumulation of U in leg bones, liver, kidneys and testes was linear. 3. Increases in U deposition with increased dosage were approximately 1:1, except for kidneys where 10-fold increases in dosage resulted in 25-fold increases in deposition. 4. Estradiol-17 beta increased U deposition in bones by 15-fold thereby providing some protection for the kidneys as now the ratio of dosage to accumulation was 1:1.
Kupsh
C C
CC
Department of Biomedical Sciences, University of Guelph, Ontario, Canada.
Robinson
G A
GA
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003370:Coturnix / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011784:Quail / Q000378:metabolism*; D013737:Testis / Q000378:metabolism; D014501:Uranium / Q000097:blood / Q000493:pharmacokinetics*
D014501:Uranium; D004958:Estradiol