title: A comparative study of the enzymatic and toxic properties of venoms of the Asian lance-headed pit viper (Genus Trimeresurus).
abstract: 1. The lethalities, anticoagulant effects, hermorrhagic, thrombin-like enzyme, hyaluronidase, protease, arginine ester hydrolase, 5'-nucleotidase, L-amino acid oxidase, alkaline phosphomonoesterase, phosphodiesterase and phospholipase A activities of twenty-three samples of venoms from twelve species of Asian lance-headed pit vipers (genus Trimeresurus) were examined. 2. The results indicate that notwithstanding individual variations in venom properties, the differences in biological properties of the Trimeresurus venoms can be used for the differentiation of venoms from different species of Trimeresurus. 3. The results also suggest that differences in the biological properties of snake venoms are useful parameters in the classification of snake species. 4. Our results indicate that venoms from the species T. okinavensis exhibited biological properties markedly different from other Trimeresurus venoms examined. This observation supports the recently proposed reclassification of T. okinavensis as a member of the genus Ovophis, rather than the genus Trimeresurus.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: A
authors.initials: A
authors.lastname: Armugam
authors.forename: C S
authors.initials: CS
authors.lastname: Tan
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001682:Biological Availability; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D003435:Crotalid Venoms / Q000493:pharmacokinetics / Q000633:toxicity*; D010450:Endopeptidases / Q000378:metabolism; D006470:Hemorrhage / Q000503:physiopathology; D050830:L-Amino Acid Oxidase; D051379:Mice; D010741:Phospholipases A / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D003435:Crotalid Venoms; D000594:Amino Acid Oxidoreductases; D050830:L-Amino Acid Oxidase; C019724:arginine esterase; D002265:Carboxylic Ester Hydrolases; D010741:Phospholipases A; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase; D010727:Phosphoric Diester Hydrolases; D010450:Endopeptidases; D013917:Thrombin