Genetic and molecular mapping of the Hmt region of mouse.
We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.
Richards
S
S
Howard Hughes Medical Institute, Dallas, TX.
Bucan
M
M
Brorson
K
K
Kiefer
M C
MC
Hunt
S W
SW
Lehrach
H
H
Lindahl
K F
KF
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D015342:DNA Probes; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D015342:DNA Probes; D015395:Histocompatibility Antigens Class I; D018800:Thy-1 Antigens; C040588:Tla antigens