[Lipid peroxidation, the enzyme antioxidative system and acid phosphatase content of the gastric mucosa in stomach ulcer].
Lipid peroxidation, a state of the antioxidative system and activity of acid phosphatase were studied in mucosal membrane of 53 patients with ulcerous disease of stomach. Increase of the acid phosphatase activity in cytoplasm, activation of lipid peroxidation and inhibition of the antioxidative system were detected in ulcer border and periulcerous region. These alterations in lipid peroxidation and the state of the antioxidative system were considered as distinct pathogenetic factors responsible for deterioration of lysosomal membranes and contributing to chronic and relapsing development of ulcerous disease.
Pasechnikov
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VD
D000135:Acid Phosphatase / Q000378:metabolism*; D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D015227:Lipid Peroxidation; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D013276:Stomach Ulcer / Q000201:enzymology / Q000378:metabolism*
D009249:NADP; D000242:Cyclic AMP; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D006867:Hydrolases; D000135:Acid Phosphatase; D005978:Glutathione; D006152:Cyclic GMP
Perekisnoe okislenie lipidov, fermentnaia antiokislitel'naia sistema i soderzhanie kisloĭ fosfatazy v slizistoĭ obolochke zheludka pri iazvennoĭ bolezni.