Chromosomal localization of zinc finger protein genes in man and mouse.
We have determined the mouse and human chromosomal location of a gene (Zfp-3) that codes for a protein that contains potential DNA zinc-binding fingers. An analysis of the segregation of restriction fragment length polymorphisms in recombinant inbred strains and in an interspecific backcross demonstrated that Zfp-3 is located on mouse chromosome 11. Zfp-3 is very closely linked to the Trp53-1 locus but unlinked to another finger protein gene Zfp-4 located on mouse chromosome 8. In humans ZFP3 has been localized to chromosome 17p12-17pter and thus is part of the conserved linkage group between this chromosome and the distal half of mouse chromosome 11.
Ashworth
A
A
Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.
Williams
B P
BP
Buchberg
A M
AM
Goodfellow
P N
PN
Solomon
E
E
Potter
J
J
Willison
K R
KR
D000818:Animals; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D008667:Metalloproteins / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D005810:Multigene Family; D012150:Polymorphism, Restriction Fragment Length; D013045:Species Specificity
D004268:DNA-Binding Proteins; D008667:Metalloproteins