Insulin-like growth factor 1 as an intra-ovarian hormone--an integrated hypothesis and review.
Fourteen ovulatory patients undergoing diagnostic laparoscopy had at least 2 samples of clear follicular fluid (FF) collected in the late follicular phase. Dominant follicles contained significantly higher concentrations of insulin-like growth factor-1 (IGF1), oestradiol (E2), progesterone (P) and lower androstenedione (AD) than their matched cohorts. After the luteinizing hormone (LH) surge, a significant increase in dominant FF-IGF1 and FF-P occurred. Log FF-E2 and log FF-P were correlated with both FF-IGF1 and FF volume. Log FF-AD was negatively correlated with FF-volume, FF-E2 and FF-P (but not FF-IGF1). The cohort concentration of FF-IGF1 was correlated with serum IGF1. These results support the hypothesis that IGF1 has a central role in the selection of the dominant follicle.
Eden
J A
JA
Department of Gynaecology, Charing Cross Hospital, London, U.K.
Carter
G D
GD
Jones
J
J
Alaghband-Zadeh
J
J
D000328:Adult; D000735:Androstenedione / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000502:physiology*; D007986:Luteinizing Hormone / Q000032:analysis; D008597:Menstrual Cycle / Q000502:physiology; D010060:Ovulation / Q000502:physiology*; D011374:Progesterone / Q000032:analysis
D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone