title: Postnatal development of the hepatobiliary transport of phenolsulfonphthalein in rats.
abstract: 1. The postnatal development of the biliary excretion of phenolsulfonphthalein (PSP) was studied in male Wistar rats. 2. Following i.v. injection of PSP at 200 mumol/kg body wt, a maximal biliary excretion of 175 +/- 10 nmol/min/100 g body wt and 32 +/- 5 nmol/min/100 g body wt was reached for unconjugated and conjugated PSP, respectively, in the adult group. 3. The maximal biliary excretion of conjugated PSP was significantly lower in the 20-, 30- and 40-day-old groups as compared to the adults. The excretion of unconjugated dye was also significantly lower in 20- and 30-day-old rats. 4. The postnatal development of PSP excretion was unrelated to changes in the activity of UDP-glucuronosyltransferase. The importance of other factors is also discussed.
authors.affiliation: Department of Physiology and Pharmacology, University of Salamanca, Spain.
authors.forename: P S
authors.initials: PS
authors.lastname: Collado
authors.forename: M E
authors.initials: ME
authors.lastname: Muñoz
authors.forename: L A
authors.initials: LA
authors.lastname: Garcia-Pardo
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000378:metabolism*; D001692:Biological Transport; D014453:Glucuronosyltransferase / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D010635:Phenolphthaleins / Q000378:metabolism*; D010637:Phenolsulfonphthalein / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010635:Phenolphthaleins; D014453:Glucuronosyltransferase; D010637:Phenolsulfonphthalein