Lymphomatoid granulomatosis in a 13-month-old infant.
Lymphomatoid granulomatosis is an infrequent, progressive, and frequently fatal vasculitis which typically occurs in middle aged males. We describe a 13-month-old infant with lymphomatoid granulomatosis who presented with chronic otitis media and "failure to thrive." Although it is well recognized that rheumatic conditions may result in failure to thrive, pediatricians often fail to consider this possibility and the proper diagnosis and treatment are correspondingly delayed. Lymphomatoid granulomatosis occurs with increased frequency in immunocompromised patients. In our case both hypogammaglobulinemia and persistent evidence of Epstein-Barr virus infection suggest that the infant was immunocompromised. Whether these factors predisposed this infant to lymphomatoid granulomatosis is uncertain. No patient with the onset of lymphomatoid granulomatosis prior to 7 years of age has been reported.
Lehman
T J
TJ
Division of Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021.
Church
J A
JA
Isaacs
H
H
D000361:Agammaglobulinemia / Q000150:complications; D005183:Failure to Thrive / Q000209:etiology; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D007223:Infant; D008230:Lymphomatoid Granulomatosis / Q000150:complications / Q000473:pathology*; D008297:Male