title: [The action of émoksipin on the basal activity of cyclic nucleotide phosphodiesterase and on the late receptor potential of the isolated retina].
abstract: The influence of emoxypin (derivate of 3-hydroxypyridine) upon the late receptor potential (LRP) and activity of the cyclic 3',5'-nucleotide phosphodiesterase (PDE) have been investigated. The inhibition of PDE and increase of the amplitude of LPR have been shown. The curve (RP as a function of the stimulus light intensity) was moved towards the lesser lighting and the time of the achievement of the maximum was increased. Thus, emoxypin produces an effect on the LRP like classical inhibitors of PDE. It is suggested that increase of the functional activity of the retinae upon the influence of emoxypin in caused by the influence of the one towards the system of the cyclic nucleotides.
authors.forename: A A
authors.initials: AA
authors.lastname: Shvedova
authors.forename: N B
authors.initials: NB
authors.lastname: Polianskiĭ
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Akopian
authors.forename: A I
authors.initials: AI
authors.lastname: Dzhafarov
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D003623:Dark Adaptation / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects*; D010847:Picolines / Q000494:pharmacology*; D011895:Rana ridibunda; D012374:Rod Cell Outer Segment / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D013997:Time Factors
chemical_list: D010847:Picolines; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; C009820:6-methyl-2-ethyl-3-hydroxypyridine
vernacular_title: Deĭstvie émoksipina na bazal'nuiu aktivnost' fosfodiésterazy tsiklicheskikh nukleotidov i pozdniĭ retseptornyĭ potentsial isolirovannoĭ setchatki.