[The role of the substrate structure in the function of Na,K-ATPase].
The mechanism of Na,K-ATPase function is reviewed. The peculiarities of hydrolysis of various substrates are described. The experimental results testify to the effect of substrate structure on the E2----E1 transition, rate of Na+ transport, K-dependent phosphatase activation and the quaternary structure of Na,K-ATPase. A conclusion is drawn that the proton-acceptor properties of the substrate play a role in the regulation of ion transport by Na,K-ATPase.
Boldyrev
A A
AA
Lopina
O D
OD
Svinukhova
I A
IA
D055598:Chemical Phenomena; D002621:Chemistry; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000254:Sodium-Potassium-Exchanging ATPase
Rol' struktury substrata v funktsionirovanii Na,K-ATPazy.