Pelizaeus-Merzbacher disease with thiamine deficiency or Leigh disease with extensive involvement of white matter? Case report.
We report on a case of a 30-month-old child who presented with a clinical syndrome compatible with leucodystrophy and in whom neuropathological features of both Pelizaeus-Merzbacher disease and subacute necrotizing encephalopathy were shown. The significance of the neuropathological findings is discussed in the light of a possible coexistence of both diseases which has not previously been reported.
Cruz-Sanchez
F F
FF
Institute of Neuropathology, Free University Berlin FRG.
Cervos-Navarro
J
J
Rossi
M L
ML
Lafuente
J V
JV
D001921:Brain / Q000473:pathology; D001928:Brain Diseases, Metabolic / Q000473:pathology*; D002675:Child, Preschool; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000150:complications / Q000473:pathology*; D006801:Humans; D007888:Leigh Disease / Q000150:complications / Q000209:etiology / Q000473:pathology*; D008297:Male; D013832:Thiamine Deficiency / Q000150:complications* / Q000473:pathology