Mesothelial papillary proliferation of the pleura associated with radiation therapy: does it have a role in the pathogenesis of mesothelioma?
Diffuse papillary proliferation of mesothelial cells in the pleura mimicking metastatic carcinoma was seen four weeks following radiation therapy for a Pancoast tumor. Such papillary proliferations are not observed incidentally and are envisioned to occur during asbestos-induced carcinogenesis. We postulate that similar papillary lesions may serve as a link in the pathogenesis of radiation-induced mesotheliomas.
Jagirdar
J
J
Frydman
C
C
Sakurai
H
H
Dumitrescu
O
O
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy; D004848:Epithelium / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D008654:Mesothelioma / Q000209:etiology*; D009362:Neoplasm Metastasis; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010994:Pleura / Q000473:pathology* / Q000528:radiation effects