Effects of intraperitoneally applied D-galactosamine on uridine and cytidine plasma content and brain activity of uridine kinase in the rat.
As determined by the HPLC technique, injection of 1.85 mmoles/kg D-galactosamine caused strong alterations in the plasma level of cytidime. Thus, 2 h and 4 h after application of the amino sugar only 54% and 61%, respectively, of the normal values were measured, while an increase to 135% of controls was observed 24 h later. In contrast, intraperitoneal application of D-galactosamine had no influence on the plasma level of uridine. The activity of the enzyme, uridine kinase, in the hippocampal area of the rat brain was increased 2 h and 4 h after D-galactosamine treatment. The results are discussed in the light of behavioural findings in which intraperitoneally applied D-galactosamine at this dosage improves the retention performance of an acquired behaviour in the rat.
Staak
S
S
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, GDR.
Popov
N
N
Matthies
H
H
D000818:Animals; D003562:Cytidine / Q000097:blood*; D005688:Galactosamine / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014529:Uridine / Q000097:blood*; D014541:Uridine Kinase / Q000378:metabolism*
D003562:Cytidine; D005688:Galactosamine; D010770:Phosphotransferases; D014541:Uridine Kinase; D014529:Uridine