KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Sporothrix sp.
New inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase, KS-501 and KS-502 were isolated from a fungus, Sporothrix sp. KAC-1985. Inhibitory concentration causing 50% inhibition (IC50) values of KS-501 and KS-502 for bovine brain enzyme were 1.8 and 4.3 microM, respectively. The compounds exhibited no or weak inhibition for calmodulin-independent cyclic-nucleotide phosphodiesterases and protein kinase C.
Nakanishi
S
S
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Ando
K
K
Kawamoto
I
I
Kase
H
H
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000037:antagonists & inhibitors*; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D005285:Fermentation; D062385:Hydroxybenzoates / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013175:Sporothrix / Q000378:metabolism*
D002147:Calmodulin; D062385:Hydroxybenzoates; C060469:KS 502; C060468:KS 501; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D002118:Calcium