title: Lisinopril dose-response relationship in essential hypertension.
abstract: 1. This was a multicentre, double-blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95-115 mm Hg) essential hypertension. 2. After a 4-week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5.20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2, 0, 2, 4, and 6. 3. There was a linear dose-response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups. 4. Lisinopril, at doses up to 80 mg day-1, was well tolerated.
authors.affiliation: Department of Cardiovascular Clinical Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065-0900.
authors.forename: H J
authors.initials: HJ
authors.lastname: Gomez
authors.forename: V J
authors.initials: VJ
authors.lastname: Cirillo
authors.forename: J A
authors.initials: JA
authors.lastname: Sromovsky
authors.forename: E S
authors.initials: ES
authors.lastname: Otterbein
authors.forename: W C
authors.initials: WC
authors.lastname: Shaw
authors.forename: J E
authors.initials: JE
authors.lastname: Rush
authors.forename: S G
authors.initials: SG
authors.lastname: Chrysant
authors.forename: A H
authors.initials: AH
authors.lastname: Gradman
authors.forename: A S
authors.initials: AS
authors.lastname: Leon
authors.forename: E P
authors.initials: EP
authors.lastname: MacCarthy
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D017706:Lisinopril