The availability of diltiazem: a study on the sorption by intravenous delivery systems and on the stability of the drug.
The stability and the sorption by intravenous delivery systems of the calcium antagonist diltiazem dissolved into either 5% dextrose or 0.9% sodium chloride solutions have been investigated, under conditions simulating current clinical practice. Static experiments showed an excellent stability and no sorption after 48 h. Dynamic experiments, at a perfusion rate of 20 mg h-1, showed no sorption of the drug by infusion fluid containers, burettes or administration sets. For end-line filters a temporary decrease of the recovered amount of diltiazem was observed but only with the 0.9% NaCl solution. It is concluded that the stability and the sorption of diltiazem offers no problem with regard to clinical efficacy.
De Vroe
C
C
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
De Muynck
C
C
Remon
J P
JP
Scheldewaert
R
R
Colardyn
F
F
D000327:Adsorption; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004355:Drug Stability; D005374:Filtration; D007262:Infusions, Intravenous; D013997:Time Factors
D004110:Diltiazem