Nonfatal demyelinating encephalomyelitis induced by coronavirus (JHM strain) infection in mice.
C3H mice infected intravenously with the JHM strain of coronavirus showed high incidence of demyelination (44.8%) and low incidence of encephalitis-induced mortality (6.9%). High titers of virus were detectable in the brain and liver of mice only during the first 3 to 12 days of infection (10(3) and 10(4) PFU/g, respectively). Most of the animals recovered from the first phase of disease and some (11.1%) came down with paralysis 6 to 7 weeks after the infection, with no histological changes or virus detectable in their tissues.
Lucchiari
M A
MA
Laboratório de Imunologia Viral, Instituto Butantan, Säo Paulo, Brasil.
Longo
M A
MA
Pereira
C A
CA
D000818:Animals; D001933:Brain Stem / Q000648:ultrastructure; D003332:Coronaviridae / Q000472:pathogenicity; D003333:Coronaviridae Infections / Q000150:complications*; D003711:Demyelinating Diseases / Q000209:etiology*; D004679:Encephalomyelitis / Q000209:etiology*; D051379:Mice; D008809:Mice, Inbred C3H