Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
Benzodiazepines can regulate neoplastic growth and immune response through specific peripheral benzodiazepine receptors. We investigated the presence of peripheral and classic central benzodiazepine receptors as well as diazepam-binding inhibitor, an endogenous ligand of both types of receptors, in different human cerebral tumors. Peripheral benzodiazepine receptors were present in all the tumor types studied, whereas central benzodiazepine receptors and diazepam-binding inhibitor were detectable in astrocytomas and glioblastomas and undetectable in meningiomas, neurinomas, and metastases. The role of diazepam-binding inhibitor and of the different benzodiazepine receptors in neoplastic cells is still to be defined.
Ferrarese
C
C
Neurological Clinic, University of Milan, Monza, Italy.
Appollonio
I
I
Frigo
M
M
Gaini
S M
SM
Piolti
R
R
Frattola
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism*; D026261:Diazepam Binding Inhibitor; D005260:Female; D005442:Flumazenil / Q000378:metabolism; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*
D026261:Diazepam Binding Inhibitor; D007546:Isoquinolines; D009479:Neuropeptides; D011963:Receptors, GABA-A; D005442:Flumazenil; C037850:PK 11195