[Effect of the portal vein injection of cisplatin and lipiodol on rat liver].
The purpose of this study was to elucidate the efficacy and safety of cisplatin powder, suspended in lipiodol, as a means for the treatment of liver cancer by injection into the portal vein. The effects of lipiodol (0.1 ml. 0.2 ml. 0.3 ml. 0.4 ml) alone, as well as that of cisplatin powder (1.0 mg) suspended in lipiodol or saline (0.1 ml), on the liver, was investigated by administration of them into the portal vein in 100 normal Wistar rats. The results revealed that the hepatic cells were moderately affected by a small amount of lipiodol alone, but a large amount of lipiodol caused multiple anemic infarctions in the peripheral area of the liver. And, also the injection of cisplatin powder suspended in lipiodol, compared to that suspended in saline, resulted in higher concentration of platinum in the liver. Histologically severe degenerative changes were also perceived in the liver, but these changes were reversible. These results suggest that cisplatin powder suspended in lipiodol is to be used for the treatment of liver cancer.
Ono
Y
Y
Dept. of Radiology, Kinki University School of Medicine.
Yoshioka
H
H
Kawakami
A
A
Ishida
O
O
Suzuki
T
T
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010984:Platinum / Q000097:blood / Q000493:pharmacokinetics; D011169:Portal Vein; D011208:Powders; D051381:Rats; D011919:Rats, Inbred Strains; D013535:Suspensions; D014018:Tissue Distribution
D011208:Powders; D013535:Suspensions; D010984:Platinum; D007459:Iodized Oil; D002945:Cisplatin