Effect of combinations of antioxidants on phagocyte-induced sister-chromatid exchanges.
Combinations of oxygen radical scavengers and antioxidants significantly reduced the number of sister-chromatid exchanges in Chinese hamster ovary cells exposed to human phagocytes stimulated to generate oxygen radicals. When vitamin E was combined with these antioxidants, no increase in sister-chromatid exchanges was observed compared to controls.
Weitberg
A B
AB
Division of Hematology/Oncology, Roger Williams Cancer Center, Providence, RI 02908.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003574:Cytochrome c Group / Q000032:analysis; D005609:Free Radicals; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D003574:Cytochrome c Group; D005609:Free Radicals; D014810:Vitamin E; D002374:Catalase; D013482:Superoxide Dismutase; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen