title: [HIV infection in stage IV C-2 (CDC). Increase in the p24 antigen value before critical decrease in CD4+ lymphocytes].
abstract: The Center for Disease Control proposed a classification system of HIV-infection including a symptomatic stage IV C-2 with secondary infections like thrush, oral hairy leukoplakia and herpes zoster. Because the prognostic value of these symptoms for the development of AIDS has been proven and the CDC-classification does not include any immunological parameters we analyzed the numbers of CD4+-lymphocytes and the frequency of HIV-antigen in 65 HIV-infected individuals. When entering stage IV C-2, the incidence of HIV-antigenemia was as high as in full blown AIDS (53% and 60%, respectively). However, we observed no decrease of CD4+-lymphocytes as compared to earlier CDC-stages.--We conclude that in stage IV C-2 the increase of viral protein production proceeds independently from CD4+-status.
authors.forename: H W
authors.initials: HW
authors.lastname: Pees
authors.forename: H
authors.initials: H
authors.lastname: Hofmann
authors.forename: R
authors.initials: R
authors.lastname: Stute
mesh_terms: D015704:CD4 Antigens / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002487:Centers for Disease Control and Prevention, U.S.; D015683:Gene Products, gag / Q000032:analysis*; D016655:HIV Core Protein p24; D015658:HIV Infections / Q000145:classification* / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D014481:United States; D014758:Viral Core Proteins / Q000032:analysis*
chemical_list: D015704:CD4 Antigens; D015683:Gene Products, gag; D016655:HIV Core Protein p24; D014758:Viral Core Proteins
vernacular_title: HIV-Infektion im Stadium IV C-2 (CDC). Zunahme der p24-Antigen-Frequenz vor der kritischen Erniedrigung der CD4+-Lymphozyten.