title: Molecular confirmation of an abortigenic strain of equine herpesvirus 1 (subtype 1) in a pregnant mare study.
abstract: Four pregnant mares were inoculated intranasally and/or intravenously with equine herpesvirus 1 (EHV-1), subtype 1 during the third trimester of gestation. One mare aborted on postinfection day 15, one mare delivered a sick, weak full term foal, and two mares delivered healthy, full term foals. EHV-1, subtype 1 was isolated from several tissues of the aborted fetus and from the thymus of the sick foal. DNA restriction endonuclease patterns of the recovered EHV-1 viruses were identical to those of the EHV-1 challenge strain, documenting the origin of the abortigenic viruses.
authors.affiliation: Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University, College Station 77843.
authors.forename: J G
authors.initials: JG
authors.lastname: Martens
authors.forename: R J
authors.initials: RJ
authors.lastname: Martens
authors.forename: R A
authors.initials: RA
authors.lastname: Crandell
authors.forename: S
authors.initials: S
authors.lastname: McConnell
authors.forename: S
authors.initials: S
authors.lastname: Kit
mesh_terms: D000034:Abortion, Veterinary / Q000382:microbiology*; D000818:Animals; D004279:DNA, Viral / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications / Q000662:veterinary*; D004861:Herpesvirus 1, Equid; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000662:veterinary*
chemical_list: D004279:DNA, Viral