Serum immunoglobulin A response to Norwalk virus infection.
We describe the serum immunoglobulin A (IgA) antibody response to Norwalk virus infection in human volunteers and compare it with previously described IgM and total antibody responses. Whereas specific IgA and IgM peak within 2 weeks after onset of symptoms, titers of total blocking antibody continue to rise, implying mediation by IgG antibody.
Erdman
D D
DD
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Gary
G W
GW
Anderson
L J
LJ
D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D001667:Binding, Competitive; D005759:Gastroenteritis / Q000276:immunology*; D006801:Humans; D007118:Immunoassay; D007070:Immunoglobulin A / Q000032:analysis / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis; D007700:Kinetics; D009663:Norwalk virus / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M