title: Peripheral neuropathy in the hypereosinophilic syndrome: a case report.
abstract: We observed a patient with the hypereosinophilic syndrome that showed as a prominent clinical feature peripheral nerve dysfunction. The neuropathy evolved over 4 months and affected sensory and motor functions. Nerve conduction studies and EMG were compatible with axonal neuropathy. Nerve and muscle biopsies revealed severe axonal degeneration with neurogenic atrophy of muscle. Morphometry of peroneal nerve showed marked axonal loss, more prominent in large myelinated fibers. There was no evidence of vasculitis process. Neuropathy is produced by eosinophil-released substances exerting a neurotoxic effect through direct altered vascular endothelial permeability and local mast cell histamine release.
authors.affiliation: Institute of Neuropsychiatry, University of Palermo, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Lupo
authors.forename: O
authors.initials: O
authors.lastname: Daniele
authors.forename: D
authors.initials: D
authors.lastname: Raimondo
authors.forename: V
authors.initials: V
authors.lastname: Rodolico
authors.forename: R M
authors.initials: RM
authors.lastname: Camarda
mesh_terms: D001706:Biopsy; D004802:Eosinophilia / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology