title: Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study.
abstract: The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
authors.affiliation: Medicine Branch, National Cancer Institute, Bethesda, Maryland.
authors.forename: S
authors.initials: S
authors.lastname: Paik
authors.forename: N
authors.initials: N
authors.lastname: Rosen
authors.forename: W
authors.initials: W
authors.lastname: Jung
authors.forename: J M
authors.initials: JM
authors.lastname: You
authors.forename: M E
authors.initials: ME
authors.lastname: Lippman
authors.forename: J F
authors.initials: JF
authors.lastname: Perdue
authors.forename: D
authors.initials: D
authors.lastname: Yee
mesh_terms: D002675:Child, Preschool; D005333:Fetus / Q000032:analysis; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D007668:Kidney / Q000032:analysis* / Q000254:growth & development; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis*; D012016:Reference Values; D013002:Somatomedins / Q000032:analysis*; D009396:Wilms Tumor / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II