title: Effects of tributyltin compounds on ionic regulation and gill ATPase activity in estuarine fish.
abstract: 1. Striped bass (Morone saxatilis) were exposed to 0, 0.10, 0.34, or 1.09 micrograms/l tributyltin (TBT) for 14 days. Gill Mg2+ ATPase and serum Na+, K+, Ca2+ and Mg2+ were not altered. Na+K+ATPase was significantly (P less than 0.05) increased (+48%) at 0.10 microgram/l. 2. In striped bass gill homogenates exposed to TBT in vitro, there was significant inhibition of Na+K+ATPase at 106.0 micrograms/l (17.2%) and Mg2+ATPase at 53.0 and 106.0 micrograms/l (16.0% and 24.3%, respectively). 3. In mummichog (Fundulus heteroclitus) gill homogenates, there was significant inhibition of Na+K+ATPase at 25.3 and 50.5 micrograms/l (10.9% and 16.1%) and Mg2+ATPase at 5.1, 25.3, and 50.5 micrograms/l (26.7%, 32.2%, and 36.2%).
authors.affiliation: University of Maryland, Center for Environmental & Estuarine Studies, Chesapeake Biological Laboratory, Solomons 20688.
authors.forename: A E
authors.initials: AE
authors.lastname: Pinkney
authors.forename: D A
authors.initials: DA
authors.lastname: Wright
authors.forename: M A
authors.initials: MA
authors.lastname: Jepson
authors.forename: D W
authors.initials: DW
authors.lastname: Towle
mesh_terms: D000818:Animals; D001492:Bass / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D003532:Cyprinodontiformes / Q000378:metabolism*; D005880:Gills / Q000187:drug effects* / Q000201:enzymology; D007695:Killifishes / Q000378:metabolism*; D008274:Magnesium / Q000097:blood; D010473:Perciformes / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014220:Trialkyltin Compounds / Q000494:pharmacology*
chemical_list: D014220:Trialkyltin Compounds; C011559:tributyltin; D012964:Sodium; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D011188:Potassium; D002118:Calcium