[Study on urinary splitting enzymes and proteins. III. Effect of non-ionic contrast medium on renal function].
Renal toxicity of non-ionic contrast medium (iohexol) for drip infused pyelography (DIP) was studied in a randomized trial of nine patients with normal renal function. Urine samples were collected before and immediately after DIP, and analyzed for albumin, an index of glomerular permeability; gamma-glutamyl transpeptidase (gamma-GTP), a brush-border enzyme; N-acetyl-beta-glucosaminidase (NAG), a lysosomal enzyme; alpha 1 microglobulin (alpha 1MG) and beta 2 microglobulin (beta 2MG), an index to tubular proteinuria; and creatinine. The urinary excretion of enzymes and proteins was compared with urinary creatinine. Urinary excretion of gamma-GTP and NAG increased significantly (P less than 0.001, 0.02) after DIP. Urinary alpha 1 MG and beta 2-MG did not change significantly. The change of urinary albumin was mild. Our data suggest that non-ionic, low osmolal radiocontrast medium ioheol shows a lower renal tubular toxicity, and the brush-border enzyme gamma-GTP and lysosomal enzyme NAG are considered as a good index for renal tubular damage.
Yasumoto
R
R
Department of Urology, Osaka Municipal Kita Citizen's Hospital.
Tanaka
S
S
Asakawa
M
M
Kakinoki
K
K
Tanabe
S
S
Nishisaka
N
N
Mori
K
K
Iseki
T
T
Wada
S
S
Maekawa
M
M
D000118:Acetylglucosaminidase / Q000652:urine*; D000368:Aged; D000419:Albuminuria; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007472:Iohexol / Q000009:adverse effects*; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014567:Urography; D005723:gamma-Glutamyltransferase / Q000652:urine*
D003287:Contrast Media; D007472:Iohexol; D005723:gamma-Glutamyltransferase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase