Alpha-adrenoceptor function in isolated penile circumflex veins from potent and impotent men.
Alpha-adrenoceptor functions were investigated in isolated human penile circumflex veins from six potent and four impotent men. Contractions elicited by noradrenaline and phenylephrine were inhibited by prazosin, yohimbine, phentolamine and papaverine. No differences were found between vessels from potent and impotent men. The results suggest that alpha-adrenoceptors in penile circumflex veins are of both alpha 1- and alpha 2-type, and that no changes in alpha-adrenoceptor function occur in impotence associated with an increased penile venous outflow.
Kirkeby
H J
HJ
Department of Urology, Aarhus Kommunehospital, Denmark.
Forman
A
A
Sørensen
S
S
Andersson
K E
KE
D000328:Adult; D000368:Aged; D007172:Erectile Dysfunction / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010410:Penile Erection; D010413:Penis / Q000098:blood supply*; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism / Q000502:physiology*; D014680:Veins / Q000187:drug effects / Q000378:metabolism; D015016:Yohimbine / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D015016:Yohimbine; D010208:Papaverine; D011188:Potassium; D009638:Norepinephrine; D011224:Prazosin; D010646:Phentolamine