title: Cervical and vaginal squamous cell abnormalities in women infected with human immunodeficiency virus.
abstract: We sought to determine whether women infected with human immunodeficiency virus (HIV) had cervicovaginal cellular changes suggesting lower genital tract neoplasia or human papillomavirus (HPV) infection at a rate different from that in women without HIV infection. In a blinded fashion, cytological preparations of cervicovaginal smears from women infected with the HIV were analyzed and compared to preparations from women at high risk for but not infected with HIV. Eleven of 35 (31%) HIV-infected subjects had evidence of squamous abnormalities compared with 1 of 23 (4%) non-HIV-infected women (p = 0.019). Nine of 35 (26%) HIV-infected women had cytohistological evidence of human papillomavirus (HPV) infection compared to 1 of 23 (4%) non-HIV-infected women (p = 0.072). We conclude that HIV-infected women have a high prevalence of cervical and vaginal cytological abnormalities and evidence of genital HPV infection. Further study is necessary to determine whether there is an increased risk for cervicovaginal neoplastic disorders in women infected with HIV.
authors.affiliation: Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467.
authors.forename: L K
authors.initials: LK
authors.lastname: Schrager
authors.forename: G H
authors.initials: GH
authors.lastname: Friedland
authors.forename: D
authors.initials: D
authors.lastname: Maude
authors.forename: K
authors.initials: K
authors.lastname: Schreiber
authors.forename: A
authors.initials: A
authors.lastname: Adachi
authors.forename: D J
authors.initials: DJ
authors.lastname: Pizzuti
authors.forename: L G
authors.initials: LG
authors.lastname: Koss
authors.forename: R S
authors.initials: RS
authors.lastname: Klein
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications / Q000473:pathology*; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006679:HIV Seropositivity / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology; D014621:Vagina / Q000473:pathology*