[The role of adenosine cyclic monophosphate (c-AMP) in the pathogenesis of epilepsy and the mechanism of the action of anti-epileptic drugs].
Modern views on the role of c-AMP and c-CMP in the regulation of metabolism and function of the neuron and synaptic transmission are presented. A hypothesis is put forward of the participation of these cyclic nucleotides in the control of epileptogenic focus through modulation of the resting potential of the neuron.
Szczechowski
L
L
Lenart-Grabowska
M
M
Marczewska
E
E
D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003864:Depression, Chemical; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D011953:Receptors, Cyclic AMP / Q000187:drug effects / Q000378:metabolism*
D000927:Anticonvulsants; D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP
Rola cyklicznego adenozynomonofosforanu (c-AMP) w patogenezie padaczki i mechanizmie działania leków przeciwpadaczkowych.