Effect of isoproterenol on the plasma C-peptide and insulin levels in humans.
There are conflicting reports on the effect of stimulation of the beta-adrenergic receptors on insulin removal by the liver. It was, therefore, the aim of the present study to clarify that problem. Four experiments have been carried out on a group of 8 healthy female volunteers: (1) isoproterenol was infused intravenously, (2) glucose was infused intravenously, (3) isoproterenol was infused with glucose, and (4) infusion of isoproterenol and glucose was preceded by administration of propranolol (the beta-adrenergic blocking agent). The concentration of C-peptide and insulin was determined in plasma from the antecubital vein. It has been found that stimulation of the beta-adrenergic receptors with isoproterenol reduces insulin removal by the human liver. This effect of isoproterenol is prevented by blockade of the beta-adrenergic receptors with propranolol.
Górski
J
J
Department of Physiology, University Medical School, Białystok, Poland.
Holm
G
G
Krotkiewski
M
M
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000328:Adult; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013565:Sympatholytics
D000318:Adrenergic beta-Agonists; D002096:C-Peptide; D007328:Insulin; D011943:Receptors, Adrenergic, beta; D013565:Sympatholytics; D011433:Propranolol; D005947:Glucose; D007545:Isoproterenol