The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.
We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.
Myklebost
O
O
Biochemistry Department, Institute for Cancer Research, Montebello, Norway.
Arheden
K
K
Rogne
S
S
Geurts van Kessel
A
A
Mandahl
N
N
Herz
J
J
Stanley
K
K
Heim
S
S
Mitelman
F
F
D000818:Animals; D001345:Autoradiography; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002874:Chromosome Mapping / Q000379:methods; D002881:Chromosomes, Human, Pair 12; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D011956:Receptors, Cell Surface / Q000235:genetics*
D015342:DNA Probes; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011956:Receptors, Cell Surface; D004247:DNA