Temporal changes in plasma and liver lipids and in the hepatic activities of acetyl-coenzyme a carboxylase and fatty acid synthetase after oestrogen treatment of the male chicken (Gallus domesticus).
1. Male chickens (Gallus domesticus) were treated with a single intramuscular injection of oestradiol-17 beta, then changes in the liver and plasma levels of triacylglycerol, phospholipid, nonesterified fatty acids and in the hepatic activities of acetyl-CoA carboxylase and fatty acid synthetase were measured at various times after injection. 2. The results suggest that the initial phase (less than 20 hr) of oestrogen-induced hyperlipidaemia occurs in the absence of changes in the hepatic activities of the major enzymes of fatty acid biosynthesis, but a subsequent increase in these enzyme activities may contribute to the later phase (greater than 20 hr) of oestrogen-induced lipogenesis in avian liver.
Manning
R
R
Department of Biological Sciences, University of Durham, England.
Courtney
S
S
Talbot
S
S
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D004247:DNA / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000378:metabolism*; D008025:Ligases / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood / Q000302:isolation & purification; D008079:Lipoproteins, VLDL / Q000302:isolation & purification; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000032:analysis; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008055:Lipids; D008079:Lipoproteins, VLDL; D011506:Proteins; D014280:Triglycerides; D004958:Estradiol; D004247:DNA; D064429:Fatty Acid Synthases; D008025:Ligases; D000103:Acetyl-CoA Carboxylase