[Effects of intrahippocampal delta-receptors on inhibition of electroconvulsive shock by electro-acupuncture].
The relationship between the delta-receptors of the hippocampus and electro-acupuncture (EA) anticonvulsions was analyzed by radioimmunoassay and microinjection. The content of leu-enkephalin-like immunoreactive substance (LEK-LIS) in perfusate from the hippocampus increased after repeated electroconvulsive shock (ECS), while the content of LEK-LIS was not changed after single ECS. EA inhibited epileptiform spikes induced by ECS, and the content of LEK-LIS decreased markedly after EA (30 +/- 9 pg/0.1 ml lower than that before EA). Leu-enkephalin (LEK), an agonist of the delta-receptors, 10 micrograms injected into the hippocampus produced epileptiform spikes. However, ICI 174,864 (4 micrograms), a specific antagonist of the delta-receptors, suppressed convulsions significantly. The results suggest that the delta-receptors of the hippocampus participate in EA anticonvulsions.
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D000818:Animals; D015671:Electroacupuncture; D004597:Electroshock; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009292:Narcotic Antagonists; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D004743:Enkephalin, Leucine; C040643:N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine