[Intraarterial chemotherapy of experimentally metastasized liver carcinoma with anticancer emulsion containing surface-active agent].
The w/o Emulsion (w/o) of 0.3% adriamycin (ADR) in the mixture of a water-soluble contrast medium, 60% urografin, and an oily contrast medium, lipiodol, at the ratio of 1 : 4 was combined with 0.5% lecithin. This combination could stabilize the micelles and make the emulsion desirably slow releasing form. ADR emulsion was injected into the hepatic artery of rabbit with metastatic liver carcinoma 7 days after intraportal transplantation of VX2 tumor. The examination at day 5 revealed good accumulation and retention of ADR in tumor. This emulsion was histologically confirmed to be effective in suppressing the growth of metastatic lesion, and it was considered that this ADR emulsion would have a great possibility for clinical application in the treatment of hepatic metastasis of gastrointestinal carcinomas.
Kitamura
Y
Y
Dep. of Surgery, Tokyo Women's Medical College.
Suzuki
H
H
Ankou
H
H
D000818:Animals; D003692:Delayed-Action Preparations; D003974:Diatrizoate Meglumine / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004655:Emulsions; D006499:Hepatic Artery; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D008297:Male; D009368:Neoplasm Transplantation; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits; D013501:Surface-Active Agents; D014018:Tissue Distribution
D003692:Delayed-Action Preparations; D004655:Emulsions; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D003974:Diatrizoate Meglumine; D007459:Iodized Oil; D004317:Doxorubicin