[Clinical investigation of urinary activity of NAG and AAP in patients with various types of primary glomerulonephritis].
We investigated the activity of NAG and AAP in the urine of 36 patients with chronic glomerulonephritis (GN) with special reference to the relation between the levels of the enzymes and histopathological changes of the kidney. The subjects consist of 7 cases of minimal change nephrotic syndrome (MCNS), 3 cases of membranous GN, 5 cases of IgA. GN, 5 cases of membranoproliferative GN, 3 cases of focal glomerulosclerosis and 12 cases of chronic renal failure who had creatinine levels of more than 2 mg/dl resulting from chronic GN. Urinary levels of NAG and AAP were significantly higher in cases with GN than those in cases with chronic renal failure. In cases with GN, urinary levels of NAG and AAP correlated with the amounts of urinary protein, while those levels had no correlation with the classification of histopathological changes of glomeruli. The high value of NAG/mg.protein ratio, NAG by urinary protein, might be explained by the degree of tublointerstitial damage. We concluded that urinary levels of NAG and AAP reflects the proximal tubular damage caused by protein reabsorption.
Soezima
A
A
Suzuki
M
M
Fukutomi
K
K
Nakabayasi
K
K
Kitamoto
K
K
Nagasawa
T
T
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000626:Aminopeptidases / Q000652:urine*; D018826:CD13 Antigens; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism* / Q000473:pathology; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*
D006596:Hexosaminidases; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens