Osmium-191/iridium-191m generator based on silica gel impregnated with tridodecylmethylammonium chloride.
A new separation system for an 191Os/191mIr generator is described. The system is composed of two columns in a series: a main column, packed with silica gel impregnated with tridodecylmethylammonium chloride (loaded with high activity 191Os as an osmyl chloride); and a scavenger column, packed with activated charcoal. Iridium-191m is eluted from the generator by pH 1 saline. For clinical use the eluate is buffered by succinate solution before injection. This new system is characterized by high performance (approximately 25% 191mIr recovery with 5 X 10(-4)% 191Os breakthrough) and long shelf-life (3 wk). The buffered eluate is sterile, pyrogen-free, and nontoxic, and contains no 192Ir. It is suitable for first-pass radionuclide angiocardiography with a very low radiation dose to the patient.
Issachar
D
D
Radiopharmaceuticals Department, Soreq Nuclear Research Center, Yavne, Israel.
Abrashkin
S
S
Weininger
J
J
Zemach
D
D
Lubin
E
E
Hellman
C
C
Trumper
J
J
D000328:Adult; D000818:Animals; D005782:Gels; D006801:Humans; D007495:Iridium / Q000302:isolation & purification*; D007554:Isotopes / Q000302:isolation & purification; D051379:Mice; D009992:Osmium / Q000302:isolation & purification*; D000644:Quaternary Ammonium Compounds; D011829:Radiation Dosage; D011868:Radioisotopes / Q000302:isolation & purification*; D011876:Radionuclide Generators; D012822:Silicon Dioxide
D005782:Gels; D007554:Isotopes; D000644:Quaternary Ammonium Compounds; D011868:Radioisotopes; D009992:Osmium; D007495:Iridium; C009543:tridodecylmethylammonium; D012822:Silicon Dioxide