The efficacies of pure LICAM(C) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate.
The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.
Stradling
G N
GN
National Radiological Protection Board, Didcot, Oxon, U.K.
Stather
J W
JW
Gray
S A
SA
Moody
J C
JC
Ellender
M
M
Hodgson
A
A
Volf
V
V
Taylor
D M
DM
Wirth
P
P
Gaskin
P W
PW
D000336:Aerosols; D000576:Americium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008745:Methylation; D009566:Nitrates; D004369:Pentetic Acid / Q000627:therapeutic use*; D011005:Plutonium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D013095:Spermidine / Q000627:therapeutic use / Q000031:analogs & derivatives; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D000336:Aerosols; D002614:Chelating Agents; D009566:Nitrates; D011005:Plutonium; C034834:LICAM-C; D004369:Pentetic Acid; D013095:Spermidine; D000576:Americium