Characterization of renal glomerular endothelin receptors in the rat.
Specific receptors for Endothelin (Et) have been identified in the glomerulus of rat kidney. Human 125I-ET binds to a single population of high affinity receptors in glomerular membranes from normal rats with a mean equilibrium dissociation constant of 200 pM. The binding was time and temperature-dependent, saturable and reversible. The Et-receptor complex was not affected by either vasopressin, atrial natriuretic factor or angiotension II.
Gauquelin
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Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
Thibault
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Garcia
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D000818:Animals; D016232:Endothelins; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D007678:Kidney Glomerulus / Q000166:cytology / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin
D016232:Endothelins; D010455:Peptides; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin