title: Superoxide anion radical production in different animal species.
abstract: The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from the housefly. The rate of O2.- generation was determined as superoxide dismutase inhibitable reduction of ferricytochrome c in the presence of antimycin A and KCN. O2.- generation was inversely related to maximum species life span potential (MLSP) (r = -0.92). A 24-fold difference in the rate of O2.- production was observed between the cow and the fly while a 6-fold difference existed among the mammals. The results are interpreted to indicate that under identical conditions, mitochondria from organisms with low MLSP have a relatively greater propensity to generate O2.-. This may be suggestive of innate differences in the molecular organization of the inner mitochondrial membrane among different species.
authors.affiliation: Department of Pathology II, University of Linköping, Sweden.
authors.forename: R S
authors.initials: RS
authors.lastname: Sohal
authors.forename: I
authors.initials: I
authors.lastname: Svensson
authors.forename: B H
authors.initials: BH
authors.lastname: Sohal
authors.forename: U T
authors.initials: UT
authors.lastname: Brunk
mesh_terms: D000818:Animals; D000838:Anions; D002417:Cattle; D005609:Free Radicals; D006793:Houseflies; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013481:Superoxides / Q000378:metabolism*; D013552:Swine
chemical_list: D000838:Anions; D005609:Free Radicals; D013481:Superoxides