title: Uterine motor responses to an alpha 2-adrenergic agonist medetomidine hydrochloride in the bitches during the end of gestation and the post-partum period.
abstract: Uterine motor responses to an alpha-2 adrenergic agonist, medetomidine hydrochloride in bitches during the end of gestation and the post-parturient period. The electrical activity of the uterine muscular coat in bitches was recorded during the end of the pregnancy and on 2nd, 4th, 6th and 8th day after the parturition, before and after intravenous injections of medetomidine in the doses of 20, 40 and 60 micrograms/kg b.w. The effect of the drug was observed 5-30 s after the injection and it lasted from 20 to 55 min. A small dose of 20 micrograms/kg b.w. caused decrease of electrical activity of the pregnant uterus. The doses of 40 and 60 micrograms/kg b.w. resulted in an increased activity of the pregnant uterus. These changes lasted 7-8 min and after that time a clear decrease till 40-55 min after the injection was observed. No abortions were observed. In all cases during the post-parturian period, the increase of the electrical activity of the uterine muscular coat was observed.
authors.forename: J
authors.initials: J
authors.lastname: Jedruch
authors.forename: Z
authors.initials: Z
authors.lastname: Gajewski
authors.forename: K
authors.initials: K
authors.lastname: Ratajska-Michalczak
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D007093:Imidazoles / Q000494:pharmacology*; D020926:Medetomidine; D009043:Motor Activity / Q000187:drug effects*; D049590:Postpartum Period / Q000187:drug effects*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D020926:Medetomidine