title: Effects of bicarbonate-containing versus lactate-containing peritoneal dialysis solutions on superoxide production by human neutrophils.
abstract: Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate-containing (pH 7.4) or lactate-containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Bicarbonate-containing peritoneal dialysis solution was found to be superior to the lactate-containing one in facilitating the production of superoxide anion by human neutrophils.
authors.affiliation: Veterans Administration Hospital, Hines, Illinois 60141.
authors.forename: F J
authors.initials: FJ
authors.lastname: Manahan
authors.forename: B L
authors.initials: BL
authors.lastname: Ing
authors.forename: J C
authors.initials: JC
authors.lastname: Chan
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: F Q
authors.initials: FQ
authors.lastname: Zhou
authors.forename: I
authors.initials: I
authors.lastname: Pal
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010530:Peritoneal Dialysis; D013481:Superoxides / Q000378:metabolism*
chemical_list: D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates; D013481:Superoxides; D019344:Lactic Acid