[Effect of the prostaglandin E produced by tumor cells on the enzymatic activity of adenosine metabolism and on human natural killer cytotoxic activity].
Adenosine deaminase (ADA) and 5'-nucleotidase (5'-N) activity and cytotoxic activity (CTA) of natural killer cells (NK-cells) isolated from human peripheral blood were studied. These cells were affected by culture medium obtained after the contact of tumour cells with NK-cells, the degree of malignancy in these cells being different. It has been established that pretreatment of NK-cells with culture medium from highly malignant cells and containing PGE, causes a sharp inhibition of their CTA, which is accompanied by an essential decrease of the ADA activity and an increase of the 5'-N activity in these cells as compared with the control.
Umanskiĭ
V Iu
VIu
Kliuchareva
T E
TE
Matveeva
V A
VA
D015720:5'-Nucleotidase; D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D006224:Cricetinae; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism*; D009700:Nucleoside Deaminases / Q000378:metabolism*; D009708:Nucleotidases / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D011458:Prostaglandins E; D009708:Nucleotidases; D015720:5'-Nucleotidase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine
Vliianie produtsiruemogo opukholevymi kletkami prostaglandina E na aktivnost' fermentov obmena adenozina i tsitotoksicheskuiu aktivnost' estestvennykh killernykh kletok cheloveka.