Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.
The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.
Wilkinson
D G
DG
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK.
Bhatt
S
S
Cook
M
M
Boncinelli
E
E
Krumlauf
R
R
D000818:Animals; D005314:Embryonic and Fetal Development; D015870:Gene Expression; D005801:Genes, Homeobox; D051379:Mice; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012249:Rhombencephalon / Q000196:embryology*; D014158:Transcription, Genetic