[Action of adaptogens: cucurbitacin R diglucoside as a stimulator of arachidonic acid metabolism in the rat adrenal gland].
It has been demonstrated that cucurbitacin R diglucoside (CRD), an adaptogen increasing the rat working capacity and stimulating corticosteroid secretion, stimulates the release of arachidonic acid (AA) in the rat adrenal cortex in vivo (the administration of CRD during 14 days) as well as in vitro (the incubation of isolated rat adrenocortical cells with CRD in the presence of eicosatetraenoic acid, the AA metabolism inhibitor) experiments. The incubation of isolated rat adrenocortical cell with CRD in the presence of AA increases the biosynthesis of 5-HETE, the precursor of which 5-HPETE is known to be a modulator of ACTH-induced corticosteroid secretion.
Panosian
A G
AG
Dadaian
M A
MA
Gevorkian
G A
GA
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D001095:Arachidonic Acids; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D006893:Hydroxyeicosatetraenoic Acids; D014315:Triterpenes; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; C008033:12-hydroxy-5,8,10-heptadecatrienoic acid; C054202:cucurbitacin R 2,25-diglucoside; D000324:Adrenocorticotropic Hormone; D015232:Dinoprostone
O deĭstvii adaptogenov: digliukozid kukurbitatsina R--stimuliator metabolizma arakhidonovoĭ kisloty v nadpochechnikakh krys.