[Molecular mechanism of calcium ion transport in mitochondria. I. Glycoprotein-peptide complex as a component of the electron transport system].
The molecular structure of the mitochondrial glycoprotein capable of forming Ca2+-selective and ruthenium red-sensitive conductance channels when incorporating into a model membrane are studied. The glycoprotein is shown to be a complex consisting of the glycoprotein itself and a low-molecular component which may be attributed to the substance of a peptide nature. A technique is elaborated to divide the complex into constituents. It is found that the channel-forming part of the complex is its peptide component. The glycoprotein component is unable to transport Ca2+ and, probably, fulfills a regulatory function.
Mironova
G D
GD
Utesheva
Zh A
ZhA
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002417:Cattle; D002850:Chromatography, Gel; D004579:Electron Transport; D008051:Lipid Bilayers; D008562:Membrane Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism*
D000596:Amino Acids; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D008051:Lipid Bilayers; D008562:Membrane Glycoproteins; D010455:Peptides; D002118:Calcium
Izuchenie molekuliarnogo mekhanizma transporta ionov kal'tsiia v mitokhondriiakh. I. Glikoproteid-peptidnyĭ kompleks kak sostavliaiushchaia chast' sistemy élektrogennogo transporta.