Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation.
Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CAl of hippocampal slices was performed after (1) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-D-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 microns distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evenly distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.
Siklós
L
L
Institute of Biophysics, Biological Research Center, Szeged, Hungary.
Kuhnt
U
U
Mihály
A
A
Joó
F
F
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D009473:Neuronal Plasticity; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D002118:Calcium