Chemotherapy-induced premature ovarian failure: mechanisms and prevention.
Significant advances have been made in the previously unexplored areas of the mechanisms involved in cyclophosphamide (CTX)-induced ovarian toxicity and the protective effects of luteinizing hormone-releasing hormone (LHRH agonists. The structure and function of granulosa cells and oocytes are affected by the chemotherapeutic agent, CTX. Results of experiments in female rats indicate that LHRH agonists may protect the ovaries from the toxic effects of chemotherapy. The protective effect may be related to the inhibition of ovarian mitotic activity during LHRH agonist administration. This inhibition is much more pronounced in female compared to male rats. This may be related to the observed better gonadal protective effects in females compared to males. Further experiments are underway to determine whether similar protective effects occur in female primates.
Ataya
K
K
Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI 48201.
Moghissi
K
K
D000818:Animals; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D006107:Granulosa Cells / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008253:Macaca mulatta; D008297:Male; D010049:Ovarian Diseases / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D011966:Receptors, LHRH / Q000187:drug effects
D011966:Receptors, LHRH; D003520:Cyclophosphamide; C011272:perfosfamide