The effect of endothelin on noradrenergic transmission in rat and guinea-pig atria.
Pre-and postjunctional effects of 10 nM endothelin have been studied in rat and guinea-pig spontaneously beating isolated atria. Endothelin increased the rate and force of contraction of atria from both species, but decreased the positive inotropic and chronotropic responses to stimulation of intramural sympathetic nerves by approximately 60% in rat and by 10-15% in guinea-pig atria. The stimulation-induced release of noradrenaline from either rat or guinea-pig atria was not significantly changed by endothelin.
Reid
J J
JJ
Department of Pharmacology, University of Melbourne, Victoria, Australia.
Wong-Dusting
H K
HK
Rand
M J
MJ
D000818:Animals; D004558:Electric Stimulation; D016232:Endothelins; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*
D016232:Endothelins; D010455:Peptides; D009638:Norepinephrine