title: [Liver calcifications in metastasizing vipoma].
abstract: A 53-year-old woman had suffered from watery diarrhoea and substitution-requiring hypokalaemia for 18 months. Ultrasonography and abdominal x-ray revealed multiple calcifications in the liver. Retrograde cholangiopancreaticography, performed because an endocrine-secreting pancreatic tumour was suspected, demonstrated occlusion of the major pancreatic duct and calcification in the body of the pancreas. Gastrointestinal hormone levels were elevated (vasoactive intestinal polypeptide 950 pg/ml, pancreatic polypeptide 1000 pmol/l and neurotensin 86 pmol/l) in the blood, and immunohistochemical results on cells of an adenocarcinoma obtained by needle biopsy confirmed a metastasizing VIPoma. Administration of the somatostatin analogue SMS 201-995 achieved marked improvement.
authors.affiliation: Medizinische Klinik III, Rheinisch-Westfälischen Technischen Hochschule, Aachen.
authors.forename: C M
authors.initials: CM
authors.lastname: Fassbender
authors.forename: R
authors.initials: R
authors.lastname: Büchsel
authors.forename: R
authors.initials: R
authors.lastname: Seelis
authors.forename: F
authors.initials: F
authors.lastname: Hofstädter
authors.forename: S
authors.initials: S
authors.lastname: Matern
mesh_terms: D007516:Adenoma, Islet Cell; D001706:Biopsy; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000150:complications*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D003969:Vipoma / Q000150:complications*
vernacular_title: Leberverkalkungen bei metastasierendem Vipom.