[Retinoid receptors in epidermoid carcinoma of the ORL sphere].
Head and neck tumors from 20 patients were investigated for the presence and the level of retinoid binding proteins (cellular retinoic acid binding protein or CRABP, cellular retinol binding protein or CRBP). A binding assay-gel filtration technic was used. CRABP were found in all tumors and in the adjacent normal tissues. A decreased level was associated with poor prognostic factors. CRBP were only found in some tumors and were absent from the adjacent normal tissue and from benign tumors. These results are discussed as regards their interest in prognostic evaluation and therapeutic orientation.
Rallet
A
A
Laboratoire de biochimie, Institut Jean-Godinot, Reims, France.
Desphieux
J L
JL
Jardillier
J C
JC
D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D011379:Prognosis; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins / Q000378:metabolism*; D054840:Retinol-Binding Proteins, Cellular
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular
Recepteurs de rétinoïdes dans les carcinomes épidermoïdes de la sphère ORL.