[Clinical trial of 111In-antimyosin antibody imaging: (3) Comparison with 99mTc-pyrophosphate imaging].
Clinical value of 111In-antimyosin monoclonal antibody F ab (AM) was compared with 99mTc-pyrophosphate (PYP) in 13 patients with myocardial infarction and 3 patients with myocarditis. Following PYP injection, PYP imaging was performed 3 hours later. Immediately after PYP imaging, AM was administrated and AM images were obtained 48 hours later. Abnormal accumulation in the infarcted myocardium was observed in 11 patients (85%) on AM images but only in 3 patients (23%) on PYP images. All patients within 8 days after the onset of infarction showed abnormal uptake on both images. Of 5 patients with 1 to 2 weeks after the onset of infarction, abnormal uptake was observed in all of them on AM images but only in one of them on PYP imaging. Furthermore, of 6 patients with more than 2 weeks after the onset, AM imaging showed abnormal uptake in 4 (67%) but PYP imaging did not show abnormal uptake in any of them. Similarly. Of 3 patients with myocarditis, diffuse uptake in the myocardium ws observed in 2 of them on AM images but none of them showed abnormal uptake on PYP images. We conclude that AM imaging is a useful means for identifying not only acute stages but also subacute stages of myocardial necrosis where PYP imaging did not show any abnormality.
Tamaki
N
N
Yamada
T
T
Matsumori
A
A
Fujita
T
T
Ohtani
H
H
Watanabe
Y
Y
Yonekura
Y
Y
Endo
K
K
Konishi
J
J
Kawai
C
C
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002986:Clinical Trials as Topic; D011756:Diphosphates; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009205:Myocarditis / Q000000981:diagnostic imaging*; D009218:Myosins / Q000276:immunology*; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
D000911:Antibodies, Monoclonal; D011756:Diphosphates; D007205:Indium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D009218:Myosins