title: Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.
abstract: The DMD gene, which spans more than 2,000 kbp, has been assigned to band Xp21 of the X chromosome. Two subclones (PERT 87-1 and PERT 87-15) of the intragenic locus DXS164 physically are separated by approximately 60 kbp. Linkage studies were done in 49 informative DMD families by using the LINKAGE program. Crossing-over between the loci studied occurred in four families. A recombination rate of 4% (support interval [Zmax-1] 1%-10%), which was 54 (support interval 14-135-fold) times higher than expected, was found with a maximum lod score of 13.50. These data suggest a hot spot for recombination within DXS164.
authors.affiliation: Institut für Humangenetik, Universität Würzburg, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Grimm
authors.forename: B
authors.initials: B
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Dreier
authors.forename: E
authors.initials: E
authors.lastname: Kind
authors.forename: T
authors.initials: T
authors.lastname: Bettecken
authors.forename: G
authors.initials: G
authors.lastname: Meng
authors.forename: C R
authors.initials: CR
authors.lastname: Müller
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D015342:DNA Probes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers