title: [Pathogenesis of acute pneumonia].
abstract: The patients with acute pneumonias demonstrated interdependent changes in lipid peroxidation (LPO), antioxidant system (AOS), immune system (IS), and in the pituitary-adrenocortical system (PAS), related to the character of the disease course. The most pronounced changes were seen in the patients with acute pneumonias eventuating in pneumofibrosis. The high level of LPO was combined with AOS depletion, immunodeficiency formation, and with dysfunction of the PAS. Antibacterial treatment did not exert any appreciable effect on the characteristics under study. Thus, the level of LPO and AOS status are important components in the pathogenesis of acute pneumonias, determining the character of the disease course and outcome. It is advisable that research work aimed at the design of the principles of antioxidant therapy may be intensified.
authors.forename: V G
authors.initials: VG
authors.lastname: Novozhenov
authors.forename: P O
authors.initials: PO
authors.lastname: Viazitskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Ermakov
authors.forename: N M
authors.initials: NM
authors.lastname: Kolomoets
authors.forename: T I
authors.initials: TI
authors.lastname: Chekushin
mesh_terms: D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000975:Antioxidants / Q000502:physiology; D000242:Cyclic AMP / Q000652:urine; D006152:Cyclic GMP / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D015227:Lipid Peroxidation; D011014:Pneumonia / Q000209:etiology* / Q000276:immunology
chemical_list: D000975:Antioxidants; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D006152:Cyclic GMP; D006854:Hydrocortisone
vernacular_title: K patogenezu ostroĭ pnevmonii.