title: Sugar modified oligonucleotides. I. Carbo-oligodeoxynucleotides as potential antisense agents.
abstract: For the first time, carbo-oligodeoxynucleotides, namely c-dT4 and c-dT12, have been synthesized. As compared to the natural oligomers these carbo-oligodeoxynucleotides are at least 5 times more stable toward enzymatic degradation and bind more strongly to complementary DNA. These preliminary data indicate that such oligomers fulfill the requirements to be considered as potential antisense agents.
authors.affiliation: Université de Montpellier II, UA 488, CNRS, France.
authors.forename: M
authors.initials: M
authors.lastname: Perbost
authors.forename: M
authors.initials: M
authors.lastname: Lucas
authors.forename: C
authors.initials: C
authors.lastname: Chavis
authors.forename: A
authors.initials: A
authors.lastname: Pompon
authors.forename: H
authors.initials: H
authors.lastname: Baumgartner
authors.forename: B
authors.initials: B
authors.lastname: Rayner
authors.forename: H
authors.initials: H
authors.lastname: Griengl
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D001482:Base Composition; D002241:Carbohydrates; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D002241:Carbohydrates; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010727:Phosphoric Diester Hydrolases