Follicular lymphoid hyperplasia of the skin with high content of Ki-1 positive lymphocytes.
We report the case of a spontaneously regressing lymphocytic lesion on the neck of a 76-year-old man. Routine histopathological examination revealed a heterogeneous infiltrate composed of both lymphoid follicles and preferentially perifollicular and interfollicular sheets of large atypical cells. Immunohistologically, large atypical cells were positive for Ki-1/Ber-H2 (CD30), anti-Il-2 (CD25), Ber T9, anti-HLA-DR, Leu-5b (CD2), T3 (CD3), Leu-3 (CD4), Leu-1 (CD5) and, occasionally, Leu-M1 (CD15); that is, they showed an arrangement and immunophenotype similar to those of perifollicular Ki-1 positive cells in reactive lymphoid tissue. In contrast, antibodies To15 (CD22), anti-immunoglobulins, and anti-CALLA (CD10) stained polyclonal B-cells restricted to lymphoid follicles and small clusters representing remnants of follicles. We suggest that this lesion be termed "follicular lymphoid hyperplasia of the skin with high content of activated T-helper cells."
Eckert
F
F
Department of Dermatology, University of Munich, F.R.G.
Schmid
U
U
Kaudewitz
P
P
Burg
G
G
Braun-Falco
O
O
D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D001706:Biopsy; D006801:Humans; D006965:Hyperplasia; D017730:Ki-1 Antigen; D008223:Lymphoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000032:analysis*
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen