BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.
In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, than in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5' members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importance.
Ghanem
N
N
Laboratoire d'Immunogénétique, URA CNRS 1191, Université des Sciences et Techniques du Languedoc, Montpellier, France.
Bensmana
M
M
Dugoujon
J M
JM
Constans
J
J
Lefranc
M P
MP
Lefranc
G
G
D000483:Alleles; D044383:Black People / Q000235:genetics*; D015245:Deoxyribonuclease BamHI; D005006:Ethnicity; D005787:Gene Frequency; D005803:Genes, Immunoglobulin; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D007129:Immunoglobulin Gm Allotypes; D015245:Deoxyribonuclease BamHI