[Contrast material for CT of the liver and spleen--an experimental study on the safety of lipiodol-iopamidol emulsion].
Iodinated oil (Lipiodol Ultra-Fluid) emulsified by non-ionic contrast material (Iopamidol) featuring much iodine and surface activity, was developed for computed tomography (CT) of the liver and spleen. The stability study revealed that Lipiodol-Iopamidol Emulsion (LIE, 1-6 microns in diameter) stored 2 weeks under refrigeration showed no visible change in globule size distribution. The biodistribution study in six rabbits revealed that LIE injected into the vein was accumulated in the liver, spleen, and lung, which have reticuloendothelial cells, however not accumulated in the brain, kidney, and serum, which have no reticuloendothelial cells. The disruption to the blood brain barrier (BBB) was assessed using Evans' Blue dye as a visual marker. After the coarse emulsion (larger than 8 microns in diameter) was injected into the internal carotid artery of three rats, the permeability of BBB increased. However, after the injection of LIE, no increased permeability of BBB was noted. Our results suggest that LIE will have a clinical application in the detection of focal hepatic and splenic lesions.
Murakami
T
T
Hori
S
S
Nishikawa
M
M
Hashimoto
T
T
Fujita
N
N
Narumi
Y
Y
Kuroda
C
C
Kozuka
T
T
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics / Q000633:toxicity*; D004355:Drug Stability; D007459:Iodized Oil / Q000493:pharmacokinetics / Q000633:toxicity*; D007479:Iopamidol / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000000981:diagnostic imaging*; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; C063672:lipiodol-iopamidol emulsion; D007459:Iodized Oil; D007479:Iopamidol