Localization studies of gamma-hydroxybutyrate receptors in rat striatum and hippocampus.
Quantitative autoradiography using [3H] gamma-hydroxybutyrate was used in combination with anatomic and neurotoxic lesions to localize the gamma-hydroxybutyrate (GHB) receptors in the striatum and hippocampus of rat brain. 6-Hydroxydopamine (6-OHDA) lesions of the nigro-striatal pathway failed to reduce [3H] gamma-hydroxybutyrate binding in the striatum. In contrast, kainic acid (KA) lesions of the caudate-putamen (CPu) resulted in about 45% loss of binding. For hippocampus, lesions of septo-hippocampal pathway did not modify receptor density but intrahippocampal kainic acid injection largely attenuated (50%) [3H] GHB binding. These results demonstrate that gamma-hydroxybutyrate receptors in the CPu and dorsal hippocampus are principally located on intrinsic neurons which may participate in the functional expression of the role gamma-hydroxybutyrate has in these structures.
Hechler
V
V
Centre de Neurochimie du CNRS, Strasbourg, France.
Gobaille
S
S
Maitre
M
M
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012978:Sodium Oxybate / Q000378:metabolism*
D006885:Hydroxybutyrates; D006892:Hydroxydopamines; D009498:Neurotoxins; D017981:Receptors, Neurotransmitter; D012978:Sodium Oxybate; D016627:Oxidopamine; D007608:Kainic Acid