Prolonged Q-T interval following astemizole overdose.
Astemizole overdose has been reported to cause torsades-de-pointes and in the present case it caused prolongation of the Q-T interval. Astemizole overdoses should be managed in a similar way to overdose with other cardiotoxic drugs.
Bishop
R O
RO
Accident and Emergency Department, Westmead Hospital, Sydney, Australia.
Gaudry
P L
PL
D000284:Administration, Oral; D000293:Adolescent; D016589:Astemizole; D001562:Benzimidazoles / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D013616:Tachycardia, Sinus / Q000139:chemically induced*; D013617:Tachycardia, Supraventricular / Q000139:chemically induced*
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole