title: The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239.
abstract: Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3.6 for alpha particles at low doses.
authors.affiliation: Departamento de Biologíe Celular e Histología, Facultad de Medicina, Universidad deĺ País Vasco, Leioa, Vizcaya, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Bilbao
authors.forename: J S
authors.initials: JS
authors.lastname: Prosser
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: J C
authors.initials: JC
authors.lastname: Moody
authors.forename: D C
authors.initials: DC
authors.lastname: Lloyd
mesh_terms: D000512:Alpha Particles; D002869:Chromosome Aberrations / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D011005:Plutonium
chemical_list: D011005:Plutonium