Adverse effects on the brain in connection with isoflurane-induced hypotensive anaesthesia.
As a marker of brain cell injury, adenylate kinase (AK) was measured in cerebrospinal fluid (CSF) in 10 patients given anaesthesia with isoflurane-induced hypotension for corrective surgery of dentofacial deformities. Nine out of 10 patients displayed a marked increase in CSF-AK postoperatively compared with preoperative values. The postoperative mean value displayed a 400% increase compared to the corresponding preoperative value. This difference was statistically significant (P = 0.001). The rise in CSF-AK was most probably the result of an enhanced efflux of AK into CSF subsequent to a presumed hypoxic injury to brain cells.
Enlund
M
M
Department of Anesthesia, Central Hospital, Västerås, Sweden.
Ahlstedt
B
B
Revenäs
B
B
Krekmanov
L
L
Ronquist
G
G
D000263:Adenylate Kinase / Q000134:cerebrospinal fluid*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled / Q000009:adverse effects*; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid* / Q000201:enzymology / Q000209:etiology; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010770:Phosphotransferases / Q000134:cerebrospinal fluid*
D007530:Isoflurane; D010770:Phosphotransferases; D000263:Adenylate Kinase