title: Radionuclide renography predicts functional changes in patients with renal artery involvement by Takayasu's arteritis.
abstract: Renovascular hypertension is a major complication of Takayasu's arteritis, which contributes to the high mortality associated with the disease. We studied 5 patients affected by different degrees of Takayasu's arteritis to assess the usefulness of radionuclide renography in evaluating renal perfusion and function, and to predict changes induced by the disease before and after therapeutic interventions. Computer-assisted dynamic renal imaging with Tc-99m diethylenetriaminepentaacetic acid (DPTA) and I-131 orthoiodohippurate (OIH), and renal arteriography were concurrently performed in all patients. Two patients with hemodynamically insignificant renal artery stenosis showed normal perfusion and function by renography. Three patients had significant renal artery stenosis and functional changes on renography. Subsequently, two of these patients had successful therapy (one had bilateral renal artery bypass grafts, and the other had renal artery angioplasty), and both showed functional improvement at renography. Our results demonstrate that radionuclide renography is valuable in the assessment of functional changes induced by Takayasu's arteritis as well as for determining the response to therapeutic interventions.
authors.affiliation: Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20892.
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: K E
authors.initials: KE
authors.lastname: McCarthy
authors.forename: D
authors.initials: D
authors.lastname: Sandrock
authors.forename: D L
authors.initials: DL
authors.lastname: Miller
authors.forename: R D
authors.initials: RD
authors.lastname: Neumann
mesh_terms: D000293:Adolescent; D000328:Adult; D001015:Aortic Arch Syndromes / Q000150:complications*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007677:Kidney Function Tests; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011866:Radioisotope Renography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000209:etiology; D013625:Takayasu Arteritis / Q000150:complications*; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate