[The hepatic hemodynamic response to intra-arterial infusion of vasoactive agents--Part 2. Blood flow measurements in rats with liver cancer].
The tissue blood flow (TBF) of primary liver cancer and normal live in 54 rats were measured following infusion of vasoactive agents into the celiac axis under continuous recording of blood pressure. Angiotensin II (AT) (1.0 micrograms/kg/min) and Prostaglandin F2 alpha (PGF) (1.0 micrograms/kg/min) were used. The former increased TBF of the tumor and blood pressure and the latter reduced TBF of the tumor with no remarkable change of the blood pressure, but both drugs made little or no influence on TBF of the normal liver. Dibutyryl cyclic AMP (DBcAMP) (2.0 mg/kg/hr) infusion increased TBF of the both tumor and normal liver with no significant change of blood pressure. PGF (1.0 micrograms/kg/min) infusion after preinfusion of DBcAMP did not cause the decrease of TBF of the tumor.
Motohashi
O
O
Kusano
S
S
Ohta
S
S
Nakayama
S
S
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003994:Bucladesine / Q000008:administration & dosage / Q000494:pharmacology*; D007261:Infusions, Intra-Arterial; D008102:Liver Circulation / Q000187:drug effects*; D008113:Liver Neoplasms / Q000503:physiopathology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011460:Prostaglandins F; D000804:Angiotensin II; D003994:Bucladesine