title: Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India.
abstract: During June to September, 1987, there were reports that a considerable segment of the population of Kashmir Valley, India, were affected by a gastrointestinal disorder. Epidemiological investigations and laboratory based studies indicated that the outbreak was associated with the consumption of bread made from mould-damaged wheat. The disease was not age or sex specific. Evidence of mould damage of wheat consisted of the presence of moulds (such as Fusarium sp, Aspergillus sp), and varying quantities of trichothecene mycotoxins (such as deoxynivalenol, nivalenol, acetyldeoxynivalenol, T-2 toxin) in samples tested. The symptoms were reproduced in dogs fed extracts of contaminated samples. The finding that trichothecene mycotoxins, especially deoxynivalenol trichothecene, cause symptoms in man emphasizes the need for a reappraisal of its safety limits in food.
authors.affiliation: Food and Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad, India.
authors.forename: R V
authors.initials: RV
authors.lastname: Bhat
authors.forename: S R
authors.initials: SR
authors.lastname: Beedu
authors.forename: Y
authors.initials: Y
authors.lastname: Ramakrishna
authors.forename: K L
authors.initials: KL
authors.lastname: Munshi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001939:Bread; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004812:Epidemiologic Methods; D005260:Female; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000453:epidemiology / Q000209:etiology*; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D008875:Middle Aged; D009183:Mycotoxins / Q000506:poisoning*; D012717:Sesquiterpenes / Q000506:poisoning*; D014255:Trichothecenes / Q000506:poisoning*; D014908:Triticum
chemical_list: D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes