title: Circulating prorenin and renin in response to intravenous adrenocorticotrophic hormone in essential hypertension.
abstract: Plasma prorenin and renin changes after a bolus injection of 25 U intravenous adrenocorticotrophic hormone (ACTH, synacthen) were studied in seven untreated uncomplicated essential hypertensives over a period of 24 h. Plasma prorenin did not change significantly during the study, whereas renin after 24 h was higher than at baseline (4.3 +/- 0.6 versus 2.3 +/- 0.9 ng angiotensin I (Ang I)/ml per h, P less than 0.01). We conclude that endogenous glucocorticoid stimulation induced by exogenous ACTH and ACTH itself seem to induce a secondary or tertiary rather than a primary effect on the human renin gene.
authors.affiliation: Centro Ipertensione, Università di Sassari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Troffa
authors.forename: G
authors.initials: G
authors.lastname: Tonolo
authors.forename: A
authors.initials: A
authors.lastname: Soro
authors.forename: P
authors.initials: P
authors.lastname: Manunta
authors.forename: M G
authors.initials: MG
authors.lastname: Melis
authors.forename: A
authors.initials: A
authors.lastname: Pazzola
authors.forename: F
authors.initials: F
authors.lastname: Pala
authors.forename: P
authors.initials: P
authors.lastname: Madeddu
authors.forename: S
authors.initials: S
authors.lastname: Alagna
authors.forename: A
authors.initials: A
authors.lastname: Masala
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000328:Adult; D004792:Enzyme Precursors / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D013997:Time Factors
chemical_list: D004792:Enzyme Precursors; D000324:Adrenocorticotropic Hormone; D012083:Renin; D006854:Hydrocortisone