[Neurohumoral mechanisms regulating renal blood circulation in patients with hypertension undergoing captopril block of angiotensin-converting enzyme].
A study was made of the effect of a single intake of captopril on the neurohumoral mechanisms of the regulation of renal circulation in 25 patients with essential hypertension (EH). Captopril induced an increase of the effective renal blood flow (ERB) and of the effective renal plasma flow along with a considerable lowering of the renal vascular resistance. No relationship was found between these changes and the time course of changes in the activity of plasma renin, aldosterone and vasopressin concentration in blood plasma. The relationship was established between the changes in the ERB and the time course of changes in baroreceptor sensitivity that significantly increased in the majority of EH patients under the effect of captopril.
Almazov
V A
VA
Ametov
A S
AS
Shliakhto
E V
EV
Dolgova
I B
IB
Pushkarev
A A
AA
D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D007465:Iodohippuric Acid; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology*; D011877:Radionuclide Imaging; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D014667:Vasopressins / Q000097:blood
D018377:Neurotransmitter Agents; D014667:Vasopressins; D007465:Iodohippuric Acid; D002216:Captopril
Neĭrogumoral'nye mekhanizmy reguliatsii pochechnogo krovoobrashcheniia u bol'nykh gipertonicheskoĭ bolezn'iu pri blokade angiotenzinprevrashchaiushchego fermenta kaptoprilom.