title: Enhancement of peripheral nerve regeneration by pharmacological activation of the cyclic AMP second messenger system.
abstract: This paper reviews the history of attempts to study peripheral nerve regeneration, focusing upon pharmacologic agents that may prove to be useful clinically. In particular, forskolin is described as a model for such an agent, and its mechanism of action, as a stimulator of the cyclic AMP second messenger system, is described.
authors.affiliation: Department of Surgery, University of California School of Medicine, Davis.
authors.forename: H W
authors.initials: HW
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: Kilmer
authors.forename: R C
authors.initials: RC
authors.lastname: Carlsen
mesh_terms: D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D004357:Drug Synergism; D007545:Isoproterenol / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D015290:Second Messenger Systems / Q000187:drug effects*; D013268:Stimulation, Chemical
chemical_list: D005576:Colforsin; D000242:Cyclic AMP; D007545:Isoproterenol