Effects of epinephrine on glucose-1,6-bisphosphate and carbohydrate metabolism in skin.
1. Injection of epinephrine induced in skin a decrease in the level of glucose-1,6-bisphosphate (Glc-1,6-P2), which was accompanied by correlated changes in the activities of several enzymes which are modulated by this regulator. 2. These effects were blocked by the alpha adrenergic blocker phentolamine, in contrast to muscle where the hormone increases Glc-1,6-P2, acting through beta receptors. 3. The changes in the enzymes' activities, as well as in glycogen and lactate content induced by epinephrine, reveal that the hormone causes, in skin, a stimulation of glycogenolysis and glycolysis, as well as an acceleration of pentose phosphate pathway. 4. The reduction in glycogen content induced by epinephrine, was blocked by the beta adrenergic blocker propranolol, whereas the hormone's effects on the other processes were mainly mediated through alpha receptors.
Bassukevitz
Y
Y
Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Chen-Zion
M
M
Beitner
R
R
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D004837:Epinephrine / Q000494:pharmacology*; D005635:Fructosediphosphates / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D010733:Phosphoglucomutase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D005635:Fructosediphosphates; D005958:Glucosephosphates; D007773:Lactates; D011942:Receptors, Adrenergic, alpha; D019344:Lactic Acid; D019298:Glucose-6-Phosphate; D000255:Adenosine Triphosphate; D006003:Glycogen; D011433:Propranolol; C016473:glucose-1,6-bisphosphate; D010734:Phosphogluconate Dehydrogenase; D010733:Phosphoglucomutase; D004837:Epinephrine; D010646:Phentolamine