[Comparison of the effect of BL 343 Ac with beta-adrenolytics on heart muscle preparations].
The paper evaluates the effect of the newly synthesized substance BL 343 Ac--propyl-4[(2-hydroxy-3-isopropylamino)-propoxy]carbanilate hydrochloride--on mechanical parameters of the myocardium of isolated guinea pig atria. At high concentrations of the substance a negative inotropic and chronotropic effect and prolongation of the functional refractory period of the preparations were recorded. These effects were comparable to those of propranolol and metipranolol. Furthermore, a mild increase in the rate of the reserpinized atria after application of 10(-7) mol.l-1 BL 343 Ac suggests a possible intrinsic sympathetic activity of the substance. BL 343 Ac has an antiisoprenaline effect with a pA2 value comparable to that of propranolol and metipranolol. However the slope of the Schild plot was different from 1, indicating that the substance possesses also other than competitively beta-adrenolytic properties.
Knezl
V
V
Sotníková
R
R
Gibala
P
P
Drímal
J
J
D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D014290:Metipranolol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D002219:Carbamates; D011412:Propanolamines; C060901:BL 343 Ac; D011433:Propranolol; D007545:Isoproterenol; D014290:Metipranolol
Porovnanie úcinkov látky BL 343 Ac s niektorými betaadrenolytikami na preparátoch srdcového svalu.