title: Frequency dependent inhibition of the nicotinic transmission by serotonin in vesical pelvic ganglia of the rabbit.
abstract: Intracellular recordings were made from neurons in rabbit vesical pelvic ganglia (VPG), in vitro. Increasing the frequency of preganglionic-nerve stimulations from 0.1-1 Hz to 10-20 Hz facilitated fast excitatory postsynaptic potentials (EPSPs), resulting in a generation of action potentials. Acetylcholine-induced response was not altered during the facilitation of the fast EPSP. Serotonin blocked action potentials elicited by preganglionic-nerve stimulations at 0.1 Hz, while it caused no blockade at 10 Hz. Serotonin may potentiate the feature of high-pass filter in transmission of VPG. Immunohistochemical study demonstrated serotonin-like varicose terminals in rabbit VPG.
authors.affiliation: Department of Physiology, Kurume University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
authors.forename: T
authors.initials: T
authors.lastname: Akasu
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D005724:Ganglia / Q000378:metabolism; D005731:Ganglionic Stimulants / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D009435:Synaptic Transmission
chemical_list: D005731:Ganglionic Stimulants; D011978:Receptors, Nicotinic; D012701:Serotonin; D000109:Acetylcholine