[Determination of the optimal dose of bromazepam in the elderly].
The aim of our study was to determine in patients over 70 years, the optimal dose of Bromazepam. Seven patients were administered a unique dose of Bromazepam (3 mg), then repeated doses (1.5 mg) every 12 hours for 9 days. Cmax was 42.5 +/- 12 ng/ml in Tmax ranged from 2 to 12 hours after the first dose-concentrations of Bromazepam at steady-state were between 79 and 157 ng/ml. Half life was 30.5 +/- 14.7 hrs for the unique and the repeated doses. Sleeping was noted for concentrations over 40 ng/ml. The dose of 1.5 mg bid is recommended in old patients.
Escande
M
M
Monjanel-Mouterde
S
S
Diadema
B
B
Coassolo
P
P
Orluc
A
A
Aubert
C
C
Durand
A
A
Cano
J P
JP
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D001007:Anxiety / Q000188:drug therapy*; D001960:Bromazepam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male
D014151:Anti-Anxiety Agents; D001960:Bromazepam
Recherche d'une posologie optimale du bromazépam chez le sujet âgé.