Phaeohyphomycosis due to Phialophora richardsiae.
Phaeohyphomycosis, an infection characterised by dematiaceous yeast-like cells, hyphae and pseudohyphae in tissue, is an uncommon condition, often affecting immunosuppressed patients. A sixty four year old boat-builder, receiving treatment with prednisone and azathioprine developed multiple cutaneous nodules on the extremities. Histology showed a mixed dermal inflammatory infiltrate with scattered spores and hyphae. Culture revealed two organisms, Phialophora richardsiae and Exophiala jeanselmei. Fluorocytosine was initially given but the organism was found to be resistant. Since side effects have been associated with long term ketoconazole therapy, a less toxic and more potent triazole compound, itraconazole, was used. After three months, the lesions had completely resolved without adverse clinical or biochemical changes.
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D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009783:Dermatitis, Occupational / Q000188:drug therapy / Q000382:microbiology*; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology*; D005093:Exophiala / Q000302:isolation & purification*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010676:Phialophora / Q000302:isolation & purification*; D014934:Wood
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole