Mutagenic lipid peroxides from edible oils.
Weak mutagenic activity was detected in several commercially available edible palm and corn oils using liquid incubation bioassays with Salmonella typhimurium TA1537. Chromatographic fractionation of unrefined palm oil established that mutagenic activity was present in three fractions that also contained fatty acyl hydroperoxides. Similar weak mutagenic activity was also demonstrated for linoleic and linolenic acid hydroperoxides. In all cases, the mutagenicity was abolished by exogenous catalase, implying that the observed activity was moderated by hydrogen peroxide.
Kensese
S M
SM
Department of Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
Teng
J I
JI
Smith
L L
LL
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003124:Colorimetry; D003314:Corn Oil / Q000032:analysis / Q000633:toxicity*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008054:Lipid Peroxides / Q000032:analysis / Q000633:toxicity*; D009153:Mutagens / Q000032:analysis; D010938:Plant Oils / Q000032:analysis / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D008054:Lipid Peroxides; D009153:Mutagens; D010938:Plant Oils; D003314:Corn Oil; D006861:Hydrogen Peroxide