title: Local chemotherapy for rectal polyposis: intraluminal administration of 5-fluorouracil for postoperative control of adenomas in the retained rectum in familial polyposis.
abstract: We administered the anticancer drug 5-fluorouracil locally to treat rectal adenomas in four patients with familial adenomatous polyposis who had undergone total colectomy and ileorectal anastomosis. The drug was administered either in suppository form or in high concentration as a rectal enema. One patient was treated successfully with 5-fluorouracil suppositories without any side effects, but the suppository regimen had to be stopped in three other patients because of severe rectal urgency. However, one of these patients was treated effectively with rectal administration of a high-dose 5-fluorouracil solution. Adenomas near the anastomotic site or dentate line were difficult to treat. Although severe urgency was seen in most patients, we think that the intraluminal administration of anticancer agents may prove effective in treating polyposis of the rectum retained after colectomy in familial polyposis. It deserves further study.
authors.affiliation: Department of Surgery I, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.forename: R
authors.initials: R
authors.lastname: Mibu
authors.forename: R
authors.initials: R
authors.lastname: Terasaka
authors.forename: K
authors.initials: K
authors.lastname: Ohsato
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000188:drug therapy*; D000285:Administration, Rectal; D000328:Adult; D003082:Colectomy; D003131:Combined Modality Therapy; D004733:Enema; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy*; D012007:Rectum / Q000601:surgery; D013488:Suppositories
chemical_list: D013488:Suppositories; D005472:Fluorouracil