Genes for beta 2-adrenergic receptor and platelet-derived growth factor receptor map to mouse chromosome 18.
The beta 2-adrenergic receptor (ADRB2R) mediates the response of various cel types to neurotransmitters, hormones, and drugs. The platelet-derived growth factor (PDGF) interacts with its receptor (PDGFR) to stimulate mesenchymal cell proliferation. In the human, ADRB2R and PDGFR have been mapped to the q31--q32 region of chromosome 5 (HSA5). Here we report the mapping of Pdgfr and Adrb2r to mouse chromosome 18 (MMU18) using somatic cell hybrid mapping techniques. Together with previous mapping of genes for the glucocorticoid receptor (human locus GRL; mouse locus Gr1-1), the class II HLA invariant chain (human locus PHLAG; mouse locus Ii) and the FMS protooncogene to HSA5 and MMU18, the assignment of both Pdgfr and Adrb2r to MMU18 expands the conserved autosomal syntenic group.
Sundaresan
S
S
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Francke
U
U
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D015342:DNA Probes; D006822:Hybrid Cells; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011943:Receptors, Adrenergic, beta / Q000235:genetics*
D015342:DNA Probes; D010982:Platelet-Derived Growth Factor; D011943:Receptors, Adrenergic, beta