High-dose intravitreal gancyclovir for cytomegaloviral (CMV) retinitis.
A patient with acquired immune deficiency syndrome (AIDS) with bilateral cytomegaloviral (CMV) retinitis who had become neutropaenic from intravenous gancyclovir, was treated with a total of 16 intravitreal 2 mg/0.1 ml doses of gancyclovir in each eye under topical anaesthesia. The injections were well tolerated with no evidence of retinal toxicity. A moderate vitreous haze which did not affect vision was the only complication. The patient retained useful vision until the time of his death, three months later.
Heery
S
S
Department of Opthalmology, Prince of Wales Hospital, Randwick New South Wales, Australia.
Hollows
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015774:Ganciclovir / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D012173:Retinitis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D014792:Visual Acuity; D014822:Vitreous Body
D015774:Ganciclovir