Virilizing granulosa cell tumor responsive to human chorionic gonadotropin and oral contraceptive with 8-year followup.
Urinary and serum steroid measurements were obtained in a 48-year-old female before and after the removal of a virilizing granulosa cell tumor (GCT). Preoperatively, serum testosterone was markedly elevated while 17-ketosteroid (17-KS) and estrogen excretion were normal. Chorionic gonadotropin administration effected a marked rise in urinary 17-KS excretion and serum testosterone while oral contraceptive therapy for 21 days decreased serum testosterone to normal. With tumor resection, serum testosterone fell to normal and subsequent administration of HCG had no stimulatory effect on serum testosterone or urinary 17-KS excretion. The patient's clinical response and 8-year followup attest to the tumor's unusual virilizing role.
Zaydon
C
C
Division of Endocrinology and Metabolism, Roger Williams General Hospital, Brown University Program in Medicine, Providence 02908.
Bogaars
H A
HA
Tucci
J R
JR
D015068:17-Ketosteroids / Q000652:urine; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014770:Virilism / Q000209:etiology*
D015068:17-Ketosteroids; D006063:Chorionic Gonadotropin; D003276:Contraceptives, Oral; D013739:Testosterone