[Effect of activation of the reticuloendothelial system on hepatocyte regeneration in partially hepatectomized rats].
Enhanced effect on rat hepatocyte regeneration through activation of the reticuloendothelial system (RES) was investigated. RES was activated using by OK-432 and the phagocytic activity (K-value) increased 2-fold over control rats 24 hours after intraperitoneal injection of OK-432. In OK-432 treated rats, the amount of cyclic AMP in the regenerating liver also increased 1.5-fold higher than in control rats 14 hours after hepatectomy. After 70% partial hepatectomy, liver DNA synthesis in OK-432 treated rats increased 2 to 5-fold higher than in control rats. There was a good correlation between the K-value before hepatectomy and DNA synthesis 24 hours after hepatectomy (r = 0.96). Therefore the RES is one of the most important regulatory factors in liver regeneration. Augmentation of RES before hepatectomy may prevent hepatic failure after resection in liver diseases.
Katoh
K
K
Second Department of Surgery, Asahikawa Medical College, Japan.
Kasai
S
S
Mito
M
M
D000818:Animals; D001973:Bromodeoxyuridine; D000242:Cyclic AMP / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D006498:Hepatectomy; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D010587:Phagocytosis; D010844:Picibanil / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats
D010844:Picibanil; D004247:DNA; D000242:Cyclic AMP; D001973:Bromodeoxyuridine