Purposeful alteration of [99mTc]-pertechnetate biodistribution.
A series of imaging studies were conducted in rats to assess the effect of stannous containing chemical species on the normal biodistribution of [99mTc]pertechnetate. The goal of the study was to determine if tissue activity could be altered by use of selected chemical agents and if such alteration could be used to clear non-target activity for enhanced image interpretation and/or to visualize two or more organ systems following a single injection of radioactivity. Two distinct patterns of tissue activity alteration could be induced. Tissue distribution studies in rats demonstrated statistically significant differences between tissue radioactivity in groups selectively studied for the type and magnitude of the induced alteration.
Pettit
W A
WA
Nuclear Medicine Service, Veterans Administration Medical Center, Iowa City, IA.
Beihn
R M
RM
D000818:Animals; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D013644:Tartrates / Q000494:pharmacology; D014018:Tissue Distribution
D013644:Tartrates; D013670:Sodium Pertechnetate Tc 99m; D010396:Penicillamine; C029768:tartaric acid