title: A strategy for measuring the therapeutic properties of new antiparkinsonian drugs, such as +PHNO, in patients with on-off fluctuations.
abstract: We describe a simple quantitative bedside method for assessing the dopaminergic properties of new therapeutic agents, namely, by documenting their duration of action in patients with Parkinson's disease who exhibit "on-off" fluctuations. This model represents a form of human dopaminergic "bioassay".
authors.affiliation: Institute of Psychiatry, London, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Coleman
authors.forename: J A
authors.initials: JA
authors.lastname: Temlett
authors.forename: N P
authors.initials: NP
authors.lastname: Quinn
authors.forename: S M
authors.initials: SM
authors.lastname: Stahl
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D010078:Oxazines; C042631:naxagolide