title: Neuroleptic-induced marching-in-place.
abstract: Marching-in-place (MIP) was observed in 12 out of 133 (9%) chronically hospitalized psychiatric patients and in none of 60 hospital staff controls. The prevalence was similar in both sexes. MIP was associated with tardive dyskinesia or parkinsonism or both but did not occur alone. Counting the number of steps per minute provides a reliable method to quantify MIP and may permit a simple objective method for investigating the neuropharmacology of this phenomenon. Preliminary observations suggest that anticholinergic agents may improve MIP in some patients but worsen it in others.
authors.affiliation: Douglas Hospital Research Centre, Verdun, Quebec, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Frost
authors.forename: S
authors.initials: S
authors.lastname: Lal
authors.forename: R
authors.initials: R
authors.lastname: Yassa
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001590:Benztropine / Q000627:therapeutic use; D002908:Chronic Disease; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D011433:Propranolol / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D001590:Benztropine; D011433:Propranolol