[Determination of growth hormone: comparison between a physiologic stimulus (exercise) and pharmacologic stimuli (clonidine/guanfacine)].
We have compared the release of growth hormone (GH) after exercise (10 minutes pedaling on a fixed bicycle with ergometer), and two pharmacological alpha-adrenergic stimuli: clonidine (CL) or guanfacine (GU); in 36 prepuberal children whose height was below the third percentile. The tests were carried out in basal conditions, randomized and with a minimum interval of seven days between them. Blood GH was determined from cannulated antecubital veins. The results show a positive response (GH greater than 7 ng/ml) in 65.7% of cases after exercise, in 74.2% after CL and 71% after GU. The significant secondary effects observed after CL administration were sleepiness and decrease of arterial pressure. It is concluded that exercise is a useful test for assessing a possible deficiency of GH, and lacks significant side effects and that the diagnostic value of GU is similar to that of CL.
García Ruiz
M L
ML
Servicio de Pediatría, Hospital Gregorio Marañón, Madrid.
Rodríguez Arnao
M D
MD
Lorenzo Navarro
L
L
Mancheño Rico
E
E
Teruel de Francisco
M C
MC
Gómez Pan
A
A
D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000494:pharmacology*; D004341:Drug Evaluation; D015444:Exercise; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D016316:Guanfacine; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine; D013006:Growth Hormone; D003000:Clonidine
Valoración de hormona de crecimiento: comparación entre un estímulo fisiológico (ejercicio) y estímulos farmacológicos (clonidina/guanfacina).