Cell-surface peptidases as modulators of growth and differentiation.
Some of the many cell-surface antigens defined by the CD (cluster differentiation) nomenclature have lately emerged as proteins with well-characterised enzymic activities. One important example is CD10 or CALLA (common acute lymphoblastic leukaemia antigen), which is identical to endopeptidase-24.11, an enzyme with an important role in the hydrolysis of biologically active peptides. CD13 and CD26 are also surface peptidases. These enzymes, which have a wide distribution on the surfaces of various cell types, may have specific roles in the control of growth and differentiation in both haemopoietic and epithelial cell systems.
Kenny
A J
AJ
Department of Biochemistry, University of Leeds.
O'Hare
M J
MJ
Gusterson
B A
BA
D000943:Antigens, Differentiation / Q000502:physiology; D000951:Antigens, Neoplasm / Q000502:physiology; D015415:Biomarkers; D001940:Breast / Q000201:enzymology / Q000648:ultrastructure; D002454:Cell Differentiation; D006128:Growth; D006412:Hematopoietic Stem Cells / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D015260:Neprilysin / Q000502:physiology*
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015415:Biomarkers; D008565:Membrane Proteins; D015260:Neprilysin