title: Plasma somatostatin activity in medullary cancer of the thyroid.
abstract: In a group consisting of 50 adults and 5 children with diagnosed or suspected medullary cancer of the thyroid, plasma somatostatin levels were measured in 77 samples with a sensitive radioimmunoassay. Only 2 patients had clearly enhanced plasma somatostatin immunoreactivity, both with highly active aggressive tumors. Other patients had plasma somatostatin levels of under 20 ng/l or undetectable ones. No evidence of response of somatostatin levels to pentagastrin stimulation was found.
authors.affiliation: Research Institute of Endocrinology, Faculty Hospital, Prague, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Neradilová
authors.forename: J
authors.initials: J
authors.lastname: Nĕmec
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
authors.forename: J
authors.initials: J
authors.lastname: Bednár
authors.forename: M
authors.initials: M
authors.lastname: Pechová
authors.forename: M
authors.initials: M
authors.lastname: Soutorová
mesh_terms: D000293:Adolescent; D000328:Adult; D002116:Calcitonin / Q000097:blood; D002277:Carcinoma / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000378:metabolism; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood*
chemical_list: D013004:Somatostatin; D002116:Calcitonin; D010418:Pentagastrin