Stimulation of HCO3- excretion in frog skin by urinary and adrenal cortical extracts.
1. There is a substance extractable from human urine which stimulates frog skin to excrete bicarbonate. The response to this extract is delayed, taking 4-9 hr, depending upon the dosage. 2. The amount of this substance varies with the bicarbonate intake of the urine donor. 3. This is a reasonable dose-response curve to the extract. 4. A substance with the same solubility characteristics, and which stimulates bicarbonate excretion with a similar time response is present in adrenal cortical extracts.
Vanatta
J C
JC
University of Texas Southwestern Medical Center, Dallas 75235-9040.
D000136:Acid-Base Equilibrium; D000302:Adrenal Cortex / Q000502:physiology*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D011894:Rana pipiens / Q000502:physiology*; D012867:Skin / Q000378:metabolism*; D014556:Urine / Q000502:physiology*
D001639:Bicarbonates