title: The role of oligosaccharides in modifying protein function.
abstract: It has been proposed that protein-bound oligosaccharides interact with the protein to which they are attached to up- or down-regulate the bioactivity of the 'composite' glycoprotein. Oligosaccharide analyses of the glycoproteins Thy-1, tissue plasminogen activator and immunoglobulin G are presented. Correlations between particular glycoforms and enzymic activities are demonstrated for tissue plasminogen activator. The change in the prevalence of particular immunoglobulin G glycoforms is shown to correlate with disease activity in rheumatoid activity.
authors.affiliation: Department of Biochemistry, University of Oxford, UK.
authors.forename: T W
authors.initials: TW
authors.lastname: Rademacher
authors.forename: R A
authors.initials: RA
authors.lastname: Dwek
mesh_terms: D000818:Animals; D000954:Antigens, Surface; D001172:Arthritis, Rheumatoid / Q000276:immunology; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology; D008958:Models, Molecular; D009844:Oligosaccharides / Q000502:physiology*; D011487:Protein Conformation; D018800:Thy-1 Antigens; D010959:Tissue Plasminogen Activator / Q000502:physiology
chemical_list: D000954:Antigens, Surface; D006023:Glycoproteins; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D018800:Thy-1 Antigens; D010959:Tissue Plasminogen Activator