title: [Comparative test of the soluble toxicity of hydroxyapatite ceramics using human and animal osteoblasts].
abstract: The soluble toxicity of 5 different hydroxylapatite granulates was tested in osteoblast cell cultures. We established a human osteoblast-like cell culture and a culture of rat (Lewis) osteoblast-like cells. The granulates were also tested in cultures of human gingival fibroblasts as a conventional system. It is demonstrated that the osteoblast-like cell cultures are of higher sensitivity than fibroblast cultures which do not show any reaction to the extracts of hydroxylapatite granulates. Only 2 hydroxylapatite granulates show some toxic. The human osteoblast-like cells reacted slightly more sensitive to toxic substances of the materials tested than rat osteoblast-like cells. It is demonstrated that the osteoblast-like cell cultures are a highly sensitive test system for materials with low toxicity.
authors.forename: H
authors.initials: H
authors.lastname: Lang
authors.forename: J P
authors.initials: JP
authors.lastname: Kruppenbacher
authors.forename: T
authors.initials: T
authors.lastname: Mertens
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D017886:Durapatite; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D006882:Hydroxyapatites / Q000633:toxicity*; D010006:Osteoblasts / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite
vernacular_title: Toxizität von Hydroxylapatitkeramiken auf menschliche und tierische Osteoblasten.