Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA.
Quisqualate- and kainate-preferring glutamate receptors were studied in Xenopus oocytes injected with rat and chick brain mRNA. All ligands effective at ionotropic quisqualate sites, agonists as well as antagonists, were found to inhibit kainate responses. Ionotropic quisqualate and kainate responses were distinguished by gamma-L-glutamylglycine but not by its D-isomer. No difference was detected between responses induced by rat brain mRNA and chick brain mRNA, suggesting that the properties of non-N-methyl-D-aspartate-type glutamate receptors of rat and chick brains are essentially the same.
Sugiyama
H
H
Department of Cellular Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Watanabe
M
M
Taji
H
H
Yamamoto
Y
Y
Ito
I
I
D000818:Animals; D002645:Chickens; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009865:Oocytes / Q000378:metabolism*; D010069:Oxadiazoles / Q000494:pharmacology*; D016318:Quisqualic Acid; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D014982:Xenopus laevis; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D010069:Oxadiazoles; D012333:RNA, Messenger; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D007051:Ibotenic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D016318:Quisqualic Acid; D007608:Kainic Acid