title: Pathologic changes in chickens caused by intravenous inoculation with fowlpox virus.
abstract: Twenty chickens were inoculated intravenously with fowlpox (FP) virus, and clinical and pathological examinations were carried out chronologically. Upon gross examination, miliary nodules scattered in the kidneys were observed from 10 to 18 days postinoculation (PI), as were papules on the skin and diphtheritic lesions on the mucous membrane of the upper respiratory tract. Microscopically, characteristic FP lesions, composed of swelling and proliferation of cells with formation of Bollinger bodies, were observed in the epithelial cells of renal tubules from 4 to 14 days PI and in the epithelial reticular cells of the thymic medulla from 4 to 10 days PI, as well as in the skin and mucous membrane. Immunofluorescent and electron microscopic observations confirmed the presence of viral antigen and virus particles in the characteristic lesions of FP.
authors.affiliation: Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Tanizaki
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: Y
authors.initials: Y
authors.lastname: Odagiri
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
mesh_terms: D000818:Animals; D002645:Chickens / Q000382:microbiology*; D005586:Fowlpox / Q000382:microbiology / Q000473:pathology*; D005587:Fowlpox virus / Q000472:pathogenicity*; D007275:Injections, Intravenous; D007668:Kidney / Q000382:microbiology / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D008854:Microscopy, Electron; D011212:Poxviridae / Q000472:pathogenicity*; D012137:Respiratory System / Q000473:pathology; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000382:microbiology / Q000473:pathology; D013997:Time Factors