[Pharmacological analysis of memory disorders of different origins].
The influence of nootropic drugs of different chemical structure and mechanism of action (piracetam 200-800 mg/kg, meclofenoxate 50-100 mg/kg, nicergoline 1-4 mg/kg) on amnestic disturbances induced with electroconvulsive shock (ECS), scopolamine (2.5 mg/kg) and phenazepam (2.0 mg/kg) was studied in mice using passive avoidance test. All the investigated drugs possess distinct protective properties concerning different models of amnesia. In ECS-induced amnesia meclofenoxate was most effective, in scopolamine-induced amnesia--meclofenoxate and nicergoline, in phenazepam-induced amnesia all drugs were equally potent in profundity. It is supposed that neurophysiological mechanism of action of nootropic drugs is connected with directed activation of weakened memory trace of different etiology and its transmission into form receivable for transcription.
Rakhmankulova
I Kh
IKh
Voronina
T A
TA
D000647:Amnesia / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D014151:Anti-Anxiety Agents; D001362:Avoidance Learning / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D008297:Male; D002504:Meclofenoxate / Q000627:therapeutic use; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D009530:Nicergoline / Q000627:therapeutic use; D010889:Piracetam / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011619:Psychotropic Drugs; D001569:Benzodiazepines; C017928:phenazepam; D002504:Meclofenoxate; D012601:Scopolamine; D009530:Nicergoline; D010889:Piracetam
Farmakologicheskiĭ analiz mnesticheskikh narusheniĭ razlichnogo geneza.