The chemical properties of silica particle surface in relation to silica-cell interactions.
Although silicosis has been studied extensively, the mechanism is still not fully understood. Experiments do provide evidence that the actions of unique properties of silica surface on the cell membrane are the starting point of silicotic processes. This paper summarizes literature on chemical properties of silica surface, and the effect of particle size on silica toxicity. This paper also discusses the ways in which silica dusts are thought to interact with the cell membrane, with emphasis on freshness, hydrogen bonding, and free-radical interactions.
Shi
X L
XL
Department of Chemistry, West Virginia University, Morgantown 26506.
Dalal
N S
NS
Hu
X N
XN
Vallyathan
V
V
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005609:Free Radicals; D006860:Hydrogen Bonding; D006861:Hydrogen Peroxide; D008563:Membrane Lipids / Q000502:physiology; D008962:Models, Theoretical; D012822:Silicon Dioxide / Q000378:metabolism / Q000633:toxicity; D014867:Water
D005609:Free Radicals; D008563:Membrane Lipids; D014867:Water; D012822:Silicon Dioxide; D006861:Hydrogen Peroxide