[Evaluation of the usefulness of forced diuresis in patients with calcium cyclobarbital or reladorm poisoning].
An attempt was made at evaluating the usefulness of forced diuresis for the treatment of Phanodorm poisoning. Fifty two patients were examined, 40 of them with Reladorm (Polish trade name. Reladorm contains 100 mg of cyclobarbital and 10 mg of diazepam) poisoning and 12 with Cyclobarbitalum Calcium (Phanodorm) poisoning. The test group was selected out of those poisoned with barbiturates so that a homogeneous toxic agent would be involved and the impact that other toxins may have on the rate of metabolism and excretion eliminated. The elimination of drug from blood was compared with the elements determining ED intensity, such as i.v. fluid administration, primary infiltrate (clearance of endogenous creatinine), reabsorption in renal tubules and diuresis rate. No correlation was found which is an evidence that ED proves to be useless in the treatment of Phanodorm poisoning. The author suggests that in this type of poisoning supportive treatment should be undertaken according to daily fluid demand in relation to such factors as sex, age, body temperature, health conditions and contraindications due to the patient's general condition.
Kołaciński
Z
Z
D001463:Barbiturates / Q000493:pharmacokinetics / Q000506:poisoning*; D003422:Critical Care; D003975:Diazepam / Q000493:pharmacokinetics / Q000506:poisoning*; D004231:Diuresis; D004338:Drug Combinations / Q000506:poisoning; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D011044:Poland
D001463:Barbiturates; D004338:Drug Combinations; C022849:reladorm; D003975:Diazepam
Ocena zasadności stosowania forsownej diurezy u chorych zatrutych Cyclobarbitalum calcium lub preparatem reladorm.