Serum beta 2-microglobulin before and after renal and heart allotransplantation and in infection.
beta 2-microglobulin (beta 2-m) serum levels were significantly elevated in patients waiting for kidney transplantation. The levels decreased after successful transplantation, even when they were never as low as in a control group of healthy blood donors. A higher amount of serum (s-) beta 2-m was observed also in heart transplant recipients. A significant reincrease in s-beta 2-m occurred during rejection of renal allograft and during CMV and EBV infection. The levels of s-beta 2-m were higher in patients infected with CMV than in those infected with EBV.


BACKGROUND
beta 2-m = beta 2-microglobulin, s-beta 2-m = serum beta 2-microglobulin, CMV = cytomegalovirus, EBV = Epstein-Barr virus.
Korcáková
L
L
Institute for Clinical and Experimental Medicine, Prague.
Svobodová
J
J
Sedlácková
E
E
Kaslík
J
J
Kaslíková
J
J
Horák
J
J
Fabián
J
J
Kocandrle
V
V
D003586:Cytomegalovirus Infections / Q000097:blood / Q000209:etiology; D006084:Graft Rejection; D016027:Heart Transplantation; D006566:Herpesviridae Infections / Q000097:blood / Q000209:etiology; D004854:Herpesvirus 4, Human; D006801:Humans; D016030:Kidney Transplantation; D011183:Postoperative Complications; D006435:Renal Dialysis; D014777:Virus Diseases / Q000097:blood* / Q000209:etiology; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin