Effect of psychosocial treatment on survival of patients with metastatic breast cancer.
The effect of psychosocial intervention on time of survival of 86 patients with metastatic breast cancer was studied prospectively. The 1 year intervention consisted of weekly supportive group therapy with self-hypnosis for pain. Both the treatment (n = 50) and control groups (n = 36) had routine oncological care. At 10 year follow-up, only 3 of the patients were alive, and death records were obtained for the other 83. Survival from time of randomisation and onset of intervention was a mean 36.6 (SD 37.6) months in the intervention group compared with 18.9 (10.8) months in the control group, a significant difference. Survival plots indicated that divergence in survival began at 20 months after entry, or 8 months after intervention ended.
Spiegel
D
D
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California.
Bloom
J R
JR
Kraemer
H C
HC
Gottheil
E
E
D000206:Actuarial Analysis; D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011615:Psychotherapy, Group; D011788:Quality of Life; D011897:Random Allocation; D012944:Social Support; D011795:Surveys and Questionnaires; D013997:Time Factors