Hepatitis B virus and hepatocellular carcinoma--treatment of HBV carriers with Phyllanthus amarus.
Extracts of Phyllanthus amarus inhibit the DNA polymerase of HBV and related viruses. Woodchuck carriers of woodchuck hepatitis virus (WHV) were treated intraperitoneally with P. amarus extract. Three of four animals which had been recently infected lost the virus. Animals infected for about 3 months or more had a decrease in virus levels. Human carriers of HBV were treated orally for 1 month. About 60% of the carriers lost HBV, which did not return during the observation period. Fractions containing active principles are now being isolated and characterized.
Blumberg
B S
BS
Fox Chase Cancer Center, Philadelphia, PA 19111.
Millman
I
I
Venkateswaran
P S
PS
Thyagarajan
S P
SP
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D006509:Hepatitis B / Q000188:drug therapy / Q000635:transmission; D006511:Hepatitis B Antigens / Q000276:immunology; D006518:Hepatitis Viruses / Q000302:isolation & purification*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D008392:Marmota; D010936:Plant Extracts / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D006511:Hepatitis B Antigens; D010936:Plant Extracts; D004259:DNA-Directed DNA Polymerase