title: Interrelationship between cyclic AMP level and chondrogenesis in vitro.
abstract: A consistent chondrogenesis takes place in micro-mass cultures of stage 23-24 chicken limb bud mesenchymal cells. In these cultures a short, marked elevation of cAMP level was detected at the time of the onset of cartilage phenotype expression. On the other hand, exogeneous glycosaminoglycans which inhibited chondrogenesis caused a reduction in the cAMP level of the cells. These correlations between cAMP level and phenotypic characteristics suggest that, among other things required in chondrogenesis, cAMP level may be a prominent factor.
authors.forename: C
authors.initials: C
authors.lastname: Hadházy
authors.forename: M B
authors.initials: MB
authors.lastname: László
mesh_terms: D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D002478:Cells, Cultured; D002642:Chick Embryo; D000242:Cyclic AMP / Q000502:physiology*; D005121:Extremities / Q000196:embryology; D006025:Glycosaminoglycans / Q000494:pharmacology; D008648:Mesoderm / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009024:Morphogenesis
chemical_list: D006025:Glycosaminoglycans; D000242:Cyclic AMP