Analytic results for quantifying HIV infectivity.
In a separate paper, we developed a mathematical model describing HIV infection and used it to suggest experiments for quantifying characteristic viral parameters. In this paper we generalize the model to any well-mixed assay system. We also present complete and rigorous derivations of fundamental results needed for the design and analysis of HIV infectivity assays. The model is applicable to infectious agents with multiple receptors for their target cell (e.g. HIV, Epstein-Barr virus and Plasmodium), and to blockers (both reversible and irreversible), as long as blocker and target cells are the same diffusion compartment.
Spouge
J L
JL
Layne
S P
SP
Dembo
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology*; D001699:Biometry; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D006801:Humans; D008962:Models, Theoretical; D011991:Receptors, Virus
D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D011991:Receptors, Virus