Transient primary hypothyroidism in the newborn: experience of the Victorian Neonatal Thyroid Screening Programme.
Between May 1977 and December 1986, the Victorian Thyroid Screening Programme tested approximately 570,000 newborns for congenital hypothyroidism. One hundred and sixty-six cases of primary hypothyroidism, confirmed by formal thyroid function tests, were identified, of which 24 were later found to be transient. In addition, there were two patients with permanent dyshormonogenesis who passed through a stage of being biochemically euthyroid and so could have been diagnosed mistakenly as transient hypothyroidism. Fourteen of the transient cases were due to excessive intake of iodine. In two, this was due to maternal ingestion of iodide during pregnancy and in 12 the babies received large amounts of topical iodine antiseptic. Two cases were caused by maternal anti-thyroid antibodies and in eight instances the cause was unknown. The large number of cases due to the topical application of iodine antiseptic emphasizes the need for caution when using this substance in neonates.
Coakley
J C
JC
Department of Clinical Biochemistry, Royal Children's Hospital, Parkville, Victoria, Australia.
Francis
I
I
Gold
H
H
Mathur
K
K
Connelly
J F
JF
D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D007074:Immunoglobulin G / Q000502:physiology; D018828:Immunoglobulins, Thyroid-Stimulating; D007231:Infant, Newborn; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D008403:Mass Screening; D011206:Povidone-Iodine / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014739:Victoria
D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D011206:Povidone-Iodine; D007455:Iodine