title: [Sulfasalazine allergy: fever, skin rash, hepatitis and T-lymphocytes].
abstract: We describe a case of severe sulfasalazine allergy. Exacerbation of the symptoms occurred after unintentional rechallenge with co-trimoxazole, indicating that the reaction was triggered by the sulphonamide component. The clinical picture consisted of generalised adenopathy, hepatitis, high fever and a maculopapular skin rash. A bone marrow biopsy and skin biopsy both showed noncaseating granulomas. The white blood cell count rose to 90.10(9)/l with 40% atypical lymphocytes (plasmacytoid). They were identified by flow cytometry as activated T lymphocytes.
authors.forename: I C
authors.initials: IC
authors.lastname: Gyssens
authors.forename: R F
authors.initials: RF
authors.lastname: de Bock
authors.forename: M E
authors.initials: ME
authors.lastname: Peetermans
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008218:Lymphocytosis / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D012460:Sulfasalazine
vernacular_title: Sulfasalazine-allergie: koorts, huidrash, hepatitis en T-lymfocytose.