title: Absence of cardio-depressant effects of CGP 17582 B, a new beta-blocking agent, in patients after coronary surgery.
abstract: The hemodynamic effects of CGP 17582 B, a new cardio-selective beta-blocking agent with moderate intrinsic sympathomimetic activity and minimal effects on myocardial contractility, were studied in patients after cardiac surgery for coronary artery bypass graft. Each patient had been treated preoperatively with beta-blocking agents and had a cineangiographic left ventricular ejection fraction between 40 and 60%. Fourteen patients were randomized to receive either 10 mg of propranolol or 50 mg of CGP 17582 B orally. Both drugs resulted in a significant and a similar decrease in heart rate. However, this was associated with a significant decrease in stroke volume after propranolol but not after CGP 17582 B, so that cardiac output significantly decreased only after propranolol. Thermodilution right ventricular ejection fraction significantly decreased after propranolol but not after CGP 17582 B. Each drug was well tolerated during the 10 following days and the recovery was uneventful in each patient. These results indicate that CGP 17582 B is a promising beta-blocking agent susceptible to reduce heart rate without altering cardiovascular function after cardiac surgery.
authors.affiliation: Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: J L
authors.initials: JL
authors.lastname: Vincent
authors.forename: A
authors.initials: A
authors.lastname: D'Hollander
authors.forename: R J
authors.initials: RJ
authors.lastname: Kahn
authors.forename: J M
authors.initials: JM
authors.lastname: De Smet
authors.forename: J L
authors.initials: JL
authors.lastname: Le Clerc
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D003864:Depression, Chemical; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D011182:Postoperative Care; D011433:Propranolol / Q000627:therapeutic use; D011897:Random Allocation
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol