Mitochondrial acetyl-CoA carboxylase. Time course of mobilization/activation in liver of refed rats.
Fasted (48 h) rats were killed at 0, 2, 4, 6, 8, 12, 16, 20 and 24 h after they were refed on a high-carbohydrate diet. An increase in the maximal activity and quantity of cystolic acetyl-CoA carboxylase was found in liver of refed rats after a lag time of about 8 h. The increased quantity of cytosolic enzyme was attributable primarily to mobilization of mitochondrial storage forms and not to substantial increase in the rate of synthesis of acetyl-CoA carboxylase.
Roman-Lopez
C R
CR
Department of Food Science and Nutrition, Ohio State University, Columbus 43210.
Shriver
B J
BJ
Joseph
C R
CR
Allred
J B
JB
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation; D008025:Ligases / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008025:Ligases; D000103:Acetyl-CoA Carboxylase