Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1).
A patient had adult T-cell leukemia-lymphoma in the unusual setting of coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type I (HTLV-I). The leukemic cells were CD4 positive and showed clonal genetic rearrangement of the T-cell receptor complex. Cytogenetic analysis showed three clonal karyotypic abnormalities: trisomy 3 and two translocations [t(1;15), (X;1)]. The patient was seropositive for HIV and HTLV-I; HTLV-I and HIV-1 DNA sequences were detected in peripheral blood leukocytes by the polymerase chain reaction. The HTLV-I sequences were detected in a relatively high proportion of mononuclear cells (at least 1 in 30 cells), whereas HIV-1 sequences were detected in a smaller proportion of cells (at least 1 in 3000 cells). Clinical remission was achieved after chemotherapy. There was a decrease in the proportion of HTLV-I positive mononuclear cells (at least 1 in 1000 cells), whereas the proportion of HIV-1 positive cells was relatively unchanged (at least 1 in 1000 cells). Adult T-cell leukemia-lymphoma in the setting of HIV coinfection may become increasingly common because asymptomatic retroviral coinfections are frequent.
Shibata
D
D
University of Southern California School of Medicine, Los Angeles.
Brynes
R K
RK
Rabinowitz
A
A
Hanson
C A
CA
Slovak
M L
ML
Spira
T J
TJ
Gill
P
P
D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D004279:DNA, Viral / Q000032:analysis; D015329:Gene Rearrangement, T-Lymphocyte; D015658:HIV Infections / Q000150:complications* / Q000235:genetics; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000235:genetics; D007958:Leukocyte Count; D008297:Male; D016133:Polymerase Chain Reaction; D050378:T-Lymphocytes, Regulatory
D004279:DNA, Viral