Effects of itraconazole on mitogen stimulated human mononuclear leucocytes.
Lymphocyte transformation responses of unstimulated and mitogen-stimulated cells from normal subjects were measured in vitro in the presence of itraconazole, at therapeutic and at much higher concentrations. No differences in response from those of control cell cultures were detected at any concentration.
Manzella
J P
JP
Division of Infectious Disease, York Hospital, PA 17405.
Clark
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology
D000935:Antifungal Agents; D008934:Mitogens; D017964:Itraconazole; D007654:Ketoconazole