[Chemico-physical property and bile acid binding capacity of several antacids].
Liquid alginate (Gaviscon) binds small amount of bile acids. At pH 7 its viscosity (at low shear rate) is higher than that of other antiacids. High viscosity reduces the diffusion rate of bile salts and glucose and this property can play a role in the treatment of gastro-esophageal and duodeno-gastric refluxes.
Salvioli
G
G
Tambara
E
E
Gaetti
E
E
Lugli
R
R
D000464:Alginates / Q000493:pharmacokinetics*; D000536:Aluminum Hydroxide / Q000493:pharmacokinetics*; D000863:Antacids / Q000493:pharmacokinetics*; D001639:Bicarbonates / Q000493:pharmacokinetics*; D001647:Bile Acids and Salts / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004338:Drug Combinations / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D012824:Silicic Acid / Q000493:pharmacokinetics*; D012822:Silicon Dioxide / Q000493:pharmacokinetics*; D017693:Sodium Bicarbonate; D014783:Viscosity
D000464:Alginates; D000863:Antacids; D001639:Bicarbonates; D001647:Bile Acids and Salts; D004338:Drug Combinations; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate
Proprietà chimico-fisiche e capacità legante gli acidi biliari di alcuni antiacidi.