Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation.
Arjunolic acid, an oleanene-type triterpene isolated from the rhizome of Cochlospermum tinctorium, its triacetate derivative, and their methyl esters were tested using the short-term in vitro assay on EBV-EA activation in Raji cells induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Their inhibitory effects on skin tumor promotors were found to be greater than those of previously studied natural products.
Diallo
B
B
Department of Pharmacognosy, U.L.B, Bruxelles, Belgium.
Vanhaelen
M
M
Vanhaelen-Fastré
R
R
Konoshima
T
T
Kozuka
M
M
Tokuda
H
H
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010946:Plants, Medicinal / Q000032:analysis*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D014315:Triterpenes; C061640:arjunolic acid