Failure of somatostatin analogue SMS 201-995 to control Cushing's syndrome due to ectopic release of ACTH from a bronchial carcinoid.
A patient with ectopic Cushing's syndrome secondary to a malignant thymic carcinoid tumour was treated with the somatostatin analogue SMS 201-995. The administration of the drug subcutaneously in increasing doses over a 34 day period failed to control the ACTH or glucocorticoid excess.
Burrell
L
L
University Department of Medicine, Royal Infirmary, Glasgow.
Gray
C E
CE
Thomson
J A
JA
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications; D002276:Carcinoid Tumor / Q000150:complications; D002828:Choristoma / Q000150:complications; D003480:Cushing Syndrome / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use*; D013950:Thymus Gland
D000324:Adrenocorticotropic Hormone; D015282:Octreotide