Relation between infection with a subtype of HPV16 and cervical neoplasia.
A variant (HPV16b) of the previously described human papillomavirus (HPV)16 (now called HPV16a) has been identified by polymerase chain reaction assays. Compared with HPV16a, HPV16b has a 21bp deletion and several point mutations within the upstream regulatory region. All cervical carcinoma samples studied contained only HPV16a. HPV16b was found only rarely in cervical neoplasia but was common in the normal population.
Tidy
J A
JA
Ludwig Institute for Cancer Research, St Mary's Branch, St Mary's Hospital Medical School, Norfolk Place, London.
Vousden
K H
KH
Farrell
P J
PJ
D002277:Carcinoma / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D004259:DNA-Directed DNA Polymerase; D004739:England; D005260:Female; D005784:Gene Amplification; D006801:Humans; D009154:Mutation; D015345:Oligonucleotide Probes; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics; D014412:Tumor Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology
D004273:DNA, Neoplasm; D004279:DNA, Viral; D015345:Oligonucleotide Probes; D004259:DNA-Directed DNA Polymerase