Midazolam does not potentiate the effect of vecuronium in patients.
Reports of midazolam interaction with vecuronium in animals prompted us to compare midazolam (0.25 mg kg-1) with thiopentone (5 mg kg-1) for possible interactions with vecuronium in patients, when used for induction of anaesthesia. After the administration of either of the two induction agents, the patients received vecuronium 0.1 mg kg-1. The onset time, duration of action and 25-75% recovery index of the neuromuscular blockade were recorded by measuring the force of thumb adduction evoked by ulnar nerve stimulation. We found no differences between patients receiving either midazolam or thiopentone in their response to vecuronium. In three of the ten patients receiving midazolam, the injection of this drug produced a 8-29% reduction of the initial twitch height.
Husby
P
P
Department of Anaesthesiology, University of Bergen, Haukeland Sykehus, Norway.
Vamnes
J S
JS
Rodt
S A
SA
Rørvik
K
K
Koller
M E
ME
Gramstad
L
L
D000328:Adult; D000771:Anesthesia, Intravenous; D004357:Drug Synergism; D006801:Humans; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D013874:Thiopental / Q000494:pharmacology; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D013874:Thiopental; D008874:Midazolam