HLA-antigen distribution in seminoma, HCG-positive seminoma and non-seminomatous tumours of the testis.
Histocompatibility antigens play a certain role in the development of testicular tumours. 151 patients with testicular cancer (86 non-seminomatous germ cell tumours--NSGCT--and 65 pure seminoma) were typed for the HLA-antigens of the A, B, C and DR locus. 24 patients of the pure seminoma group and 50 patients of the NSGCT group had an elevated serum HCG level preoperatively. The antigen DR-5 was elevated in the seminoma group whereas the incidence of B-13 was increased in the NSGCT group. In terms of antigen distribution HCG-positive seminoma resembles seminomatous tumours rather than NSGCT.
Kratzik
C
C
Department of Urology, University of Vienna Medical School, Austria.
Aiginger
P
P
Kuzmits
R
R
Spona
J
J
Kirnbauer
M
M
Seiser
A
A
Mayr
W R
WR
D006063:Chorionic Gonadotropin / Q000097:blood*; D004407:Dysgerminoma / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology*
D006063:Chorionic Gonadotropin; D006680:HLA Antigens; D006684:HLA-DR Antigens