Silica prevents the induction of diabetes with complete Freund's adjuvant and low-dose streptozotocin in rats.
Three weekly intraperitoneal injections of complete Freund's adjuvant (CFA) and, one day later, 25 mg/kg of STZ have been reported to cause a gradual onset of autoimmune diabetes. We have previously reported that the onset of diabetes in this model occurs too rapidly to be due to a specific immune reaction and that other compounds that activate macrophages also potentiate low-dose STZ in rats. We have proposed that mediators released from activated macrophages may enhance the cytotoxic effect of STZ. In the present study, we have observed that intraperitoneal injections of silica, a macrophage toxin, markedly decrease the incidence and severity of diabetes induced with CFA and low-dose STZ.
Wright
J R
JR
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Lacy
P E
PE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D005620:Freund's Adjuvant / Q000633:toxicity; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012822:Silicon Dioxide / Q000627:therapeutic use*; D013311:Streptozocin / Q000633:toxicity
D001786:Blood Glucose; D013311:Streptozocin; D012822:Silicon Dioxide; D005620:Freund's Adjuvant