[Macrophage disappearance reaction in mice during an infection caused by Coxsackie B3 virus].
Intraperitoneal inoculation of 2 1/2-3-month-old male BALB/c mice with Coxsackie B3 virus in a dose of 10(7.2) TCD50 was demonstrated to be accompanied by inhibition of the starch-induced exudation of leukocytes into the peritoneal cavity. A decrease in the number of macrophages was observed in 3-day exudates induced at 4 and 21 days but not at 0, 7, and 14 days of infection. The macrophage disappearance reaction showed that the intraperitoneal inoculation of the challenge virus dose (10(7.2) TCD50) was not accompanied at 4-5 hours by changes in the absolute number of macrophages in the pre-existing exudates, but an increase in the absolute number of lymphocytes was observed in the exudates induced at 0, 4, 7, and 14 days of infection, and of polymorphonuclear leukocytes in exudates induced at all the intervals studied. It is assumed that these changes, depending on the period of infection, may be determined by immunological and non-immunological mechanisms.
Shestenko
O P
OP
Bocharov
E F
EF
D000818:Animals; D003384:Coxsackievirus Infections / Q000276:immunology* / Q000382:microbiology; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005122:Exudates and Transudates / Q000276:immunology; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity; D013213:Starch
D013213:Starch
Reaktsiia ischeznoveniia makrofagov pri infektsii mysheĭ, byzvannoĭ virusom Koksaki B3.