[Effect of treatment with enalapril maleate on the levels of circulating catecholamines, beta endorphins, prostaglandins, and concentration of sodium in erythrocytes in patients with essential hypertension].
An effect of enalapril maleate on the activity of renin-angiotensin-aldosterone system and sympathetic reactivity, erythrocyte prostaglandin and sodium levels as well as blood beta-endorphin was investigated in 28 patients with the essential arterial blood hypertension. It was found that enalapril maleate significantly increased plasma renin activity, decreased plasma norepinephrine and its 24-hour excretion, and decreased erythrocyte beta-endorphin and sodium levels. Blood epinephrine and aldosterone levels and their daily excretion remained unchanged similarly to prostaglandins. The above results suggest that a decrease in sympathetic system activity and intracellular sodium concentration may play a role in the hypotensive action of enalapril maleate related to the inhibition of angiotensin II formation.
Chodakowska
J
J
Wocial
B
B
Ignatowska-Switalska
H
H
Knypl
K
K
Brym
E
E
Czerniewska
E
E
Wacławek-Maczkowska
J
J
Jabłońska-Skwiecińska
E
E
Drygieniec
D
D
Januszewicz
W
W
D000328:Adult; D002395:Catecholamines / Q000097:blood; D004656:Enalapril / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000097:blood*; D001615:beta-Endorphin / Q000097:blood*
D002395:Catecholamines; D011453:Prostaglandins; D001615:beta-Endorphin; D004656:Enalapril; D012964:Sodium
Wpływ leczenia maleinianem enalaprylu na stezenie krazacych amin katecholowych, beta-endrofiny, prostaglandyny oraz stezenie sodu w krwinkach czerwonych u chorych na pierwotne nadciśnienie tetnicze.