title: Invasive adenylate cyclase toxin of Bordetella pertussis.
abstract: Bordetella pertussis produces an adenylate cyclase which is a toxin. The enzyme penetrates eukaryotic cells and, upon activation by host calmodulin, generates high levels of intracellular cAMP; as a result bactericidal functions of immune effector cells are considerably impaired. The toxin is composed of a single polypeptide that possesses both the catalytic and the toxic functions. It penetrates the host cell directly from the plasma membrane and is concomitantly inactivated by a proteolytic degradation.
authors.forename: E
authors.initials: E
authors.lastname: Hanski
mesh_terms: D037361:Adenylate Cyclase Toxin; D000262:Adenylyl Cyclases / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001886:Bordetella pertussis / Q000201:enzymology*; D002118:Calcium / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis; D004789:Enzyme Activation; D005798:Genes, Bacterial; D006801:Humans; D010566:Virulence Factors, Bordetella / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity
chemical_list: D037361:Adenylate Cyclase Toxin; D002147:Calmodulin; D010566:Virulence Factors, Bordetella; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium