title: The spindle-shaped cells in cutaneous Kaposi's sarcoma. Histologic simulators include factor XIIIa dermal dendrocytes.
abstract: Kaposi's sarcoma is a neoplasm that develops as multifocal lesions, often involving the skin, characterized by a complex histologic picture including numerous vascular spaces, perivascular and interstitial spindle-shaped cells, and extravasated erythrocytes, lymphocytes, and plasma cells. Using an antibody against factor XIIIa, which identifies dermal dendrocytes, numerous factor XIIIa-positive dermal dendrocytes were detected among the spindle-shaped cells in 12 acquired immune deficiency syndrome (AIDS)-associated, and five non-AIDS-associated Kaposi's sarcoma lesions. The factor XIIIa-positive dermal dendrocytes were also increased in histologic simulators of Kaposi's sarcoma such as dermatofibroma, angiomatoid malignant fibrous histiocytoma, granuloma annulare, and early wound healing, but were absent in keloids. The increased number of dermal dendrocytes, which are often in an angiocentric configuration and which also express CD4, lymphocyte function associated antigen-1 (LFA-1), and Leu M3 in Kaposi's sarcoma, may be important to the angioproliferative response. The results suggested that the spindle-shaped cells that are present in a variety of cutaneous lesions are dermal dendrocytes and belong to the reticuloendothelial system, unlike other mesenchymal cell types such as the endothelial cell. Apparently a diverse array of stimuli, including human immunodeficiency virus type-1 (HIV-1) infection and trauma, can stimulate the accumulation of factor XIIIa expressing dermal dendrocytes in the skin. These cells can then participate in different stages of a variety of cutaneous alterations including Kaposi's sarcoma, dermatofibroma, granuloma annulare, and early wound healing. Thus, the factor XIIIa-positive dermal dendrocyte is a common cellular denominator among diverse clinical entities that share some histologic features.
authors.affiliation: Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109-0602.
authors.forename: B J
authors.initials: BJ
authors.lastname: Nickoloff
authors.forename: C E
authors.initials: CE
authors.lastname: Griffiths
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015497:HIV-1; D006716:Homosexuality; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000032:analysis / Q000209:etiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000032:analysis / Q000209:etiology / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis*
chemical_list: D009418:S100 Proteins; D011503:Transglutaminases