Structural chromosome aberrations in lymphocytes from children previously treated for Wilms' tumor or Hodgkin's disease.
Nineteen children treated for Wilms' tumor (thirteen cases) or Hodgkin's disease (six cases) with cytostatic agents and/or radiotherapy were studied cytogenetically on lymphocytes cultivated from blood samples drawn after at least 1 year of complete remission after end of therapy. A reference group of children was matched for age, sex, and residence. The frequencies of sister chromatid exchange (5.4 versus 5.6 SCE/cell), and chromosome damage type gaps (6.6 versus 7.1%) and breaks (1.9 versus 1.9%) were not different in the two groups, but exchange type aberrations were more frequent in the patients (0.9 versus 0.06%). Fifty karyotypes were analyzed in all but two cases of Hodgkin's disease. The overall frequency of stable (3.1 versus 3.8%) and unstable (1.7 versus 1.4%) structural chromosome changes such as translocations, deletions, chromatid exchanges, and dicentrics were not different in the patient and the control groups. If the chromosome data reflect a general cancer risk, this risk cannot be considerably higher among the cancer-treated children.
Brøgger
A
A
Department of Genetics, Norwegian Radium Hospital, Montebello, Oslo.
Kolmannskog
S
S
Nicolaysen
R B
RB
Wesenberg
F
F
Nygaard
R
R
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary; D011878:Radiotherapy / Q000009:adverse effects*; D012306:Risk; D012854:Sister Chromatid Exchange; D009396:Wilms Tumor / Q000628:therapy*