In vitro effect of methionine-enkephalin and thymosin on murine expression of Thy1-2 antigen.
The present study investigates the in vitro effect of methionine-enkephalin (Met-Enk) on Thy1-2 antigen density and the interaction between this opioid peptide and a thymic hormone (thymosin fraction V (TFV]. In vitro, it was found that Met-Enk at various concentrations (28.10(-11), 28.10(-10), 28.10(-9) and 28.10(-8) M) had an increased positive effect on the Thy1-2 antigen density of Balb/C mouse thymocytes. This action was observed at all concentrations of Met-Enk. The addition of TFV to Met-Enk thymocyte cultures showed an additive effect of these two hormones. The physiological significance of these observations is that they indicate an interaction between immune and endocrine system functions.
Chakir
J
J
Laboratory of Animal Physiology, General and Comparative Immunology, University of Limoges, France.
Rouabhia
M
M
Deschaux
P
P
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015213:Neuroimmunomodulation / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018800:Thy-1 Antigens; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000954:Antigens, Surface; D018800:Thy-1 Antigens; C033782:thymosin fraction 5; D004744:Enkephalin, Methionine; D013947:Thymosin