[The development of desensitization during rhythmic activity of the synapse and in the course of generating a single signal].
The possibility of desensitization (DS) development under the rhythmic activity and during the generation of the single response to acetylcholine was studied in the frog sartorius muscle by voltage-clamp technique. It was revealed, that under conditions promoting DS (hyperpolarization, muscle warming, rise of calcium concentration as well as treatment by the DS--potentiating agent--proadifen) decrease of the postsynaptic membrane sensitivity to the acetylcholine can develop after few multiquantal end-plate currents--and when acetylcholinesterase is inhibited--during the response to a single quantum of acetylcholine.
Giniatullin
R A
RA
Khazipov
R N
RN
D000818:Animals; D002800:Cholinesterase Inhibitors; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology*; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D011335:Proadifen / Q000494:pharmacology; D011898:Ranidae; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D017981:Receptors, Neurotransmitter; D009388:Neostigmine; D011335:Proadifen
Razvitie desensitizatsii pri ritmicheskoĭ aktivnosti sinapsa i v khode generatsii odinochnogo signala.