8-Methyladenosine-substituted analogs of 2-5A: synthesis and properties.
Four 8-methyladenosine-substituted analogs of 2-5A were obtained by a synthesis which involved a modification of the lead ion-catalyzed ligation reaction. Substituent of an 8-methyladenosine residue at the third position (2'-terminal) of the oligonucleotides increased the stability to snake venom phosphodiesterase digestion.
Kitade
Y
Y
Medicinal Chemistry, Gifu Pharmaceutical University, Japan.
Nakata
Y
Y
Hirota
K
K
Maki
Y
Y
Pabuccoglu
A
A
Torrence
P F
PF
D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D000241:Adenosine / Q000031:analogs & derivatives*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom; D000241:Adenosine