title: [Malignant mesodermal mixed tumor of the ovary with neuro-ectodermic differentiation].
abstract: A striking ovarian tumour was observed in a post-menopausal, 54-year-old woman. Most of the tumour shows histologic features of a malignant mesodermal (müllerian) mixed tumour. However, this tumour harbours a peculiar component suggesting neuroectodermal neoplasia. Histochemical and immunohistochemical studies demonstrate focal pheochromocytomatous (or paraganglionic) and ganglionic differentiations. Several types of cells could be identified: ganglion cells (NSE +, neurofilaments +), pheochromocytes or paraganglion cells (chromogranin +), Schwann cells (S 100 protein +), and neuroblastomatous elements (NSE +). This neoplastic component could be compared with compound tumours such as pheochromocytomaganglioneuroblastoma or gangliocytic paraganglioma. This type of tumour has not been reported in ovary, notably in association with a mesodermal mixed tumour. Such observation prompts us to consider tumours of somatic origin containing germ cell-type elements, with a review of the literature.
authors.affiliation: Laboratoire d'Anatomie pathologique, Faculté de Médecine, Hôpital Bretonneau, Tours.
authors.forename: F
authors.initials: F
authors.lastname: Fetissof
authors.forename: B
authors.initials: B
authors.lastname: Arbeille
authors.forename: J
authors.initials: J
authors.lastname: Lansac
authors.forename: Y
authors.initials: Y
authors.lastname: Lhuintre
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000201:enzymology / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000473:pathology*
vernacular_title: Tumeur mixte mésodermique maligne de l'ovaire avec contingent neuro-ectodermique.