Chromosome changes in a brain metastasis of a large cell lung cancer.
Direct chromosome preparations were made on a brain metastasis of a large cell lung cancer from a 46-year-old female patient. In the 169 cells examined, the modal chromosomes number was 73, and the majority (53.2%) of mitoses were in the near-triploid region. The tumor cells showed considerable heterogeneity in chromosome number and content. Chromosomes 3, 4, and 5 were the most frequently involved in aberrations. The mean number of unidentified marker chromosomes was five per mitosis.
Selypes
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Department of Hygiene and Epidemiology, Albert Szent-György Medical University, Szeged, Hungary.
László
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D001932:Brain Neoplasms / Q000235:genetics / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged
D005819:Genetic Markers