Possible mechanisms of diethyldithiocarbamate-induced gastro-duodenal mucosal damage in rats.
A single s.c. injection of diethyldithiocarbamate (DDC, 1 g/kg) induced not only gastric but also duodenal mucosal damage in rats. DDC induced marked decreases in gastric acid output, gastro-duodenal mucosal blood flow and transmucosal potential difference prior to the development of mucosal lesions. Superoxide dismutase activity in the gastro-duodenal mucosa was also inhibited, while catalase and glutathione peroxidase activities gradually increased after the administration of DDC. These results suggest that a decrease in mucosal defensive mechanisms plays an important role in the development of DDC-induced gastro-duodenal mucosal damage and that oxygen-derived free radicals may also participate in the development of this mucosal damage.
Takamasu
M
M
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Fuse
Y
Y
Kawamoto
K
K
Kodama
T
T
Ohishi
T
T
D000818:Animals; D001696:Biomechanical Phenomena; D002374:Catalase / Q000378:metabolism; D004050:Ditiocarb / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
D004050:Ditiocarb; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase