Poliovaccine virus in the cerebrospinal fluid after oral polio vaccination.
In February-March 1985 an oral poliovirus vaccine campaign was launched in Finland in a population vaccinated earlier with inactivated poliovaccine. During this campaign a strain of poliovirus was isolated from the cerebrospinal fluid (CSF) of a 7-year-old girl 34 days after she had received oral poliovirus vaccine. She had long-lasting headache, vomiting and fever but no paralysis. This case demonstrates that poliovaccine virus can invade the central nervous system even after a complete course of inactivated poliovirus vaccine if the inactivated vaccine has been poorly antigenic against one of the three types of virus.
Rantala
H
H
Department of Pediatrics, University of Oulu, Finland.
Uhari
M
M
Tuokko
H
H
Stenvik
M
M
Kinnunen
L
L
D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002648:Child; D005260:Female; D006801:Humans; D017955:Poliovirus / Q000302:isolation & purification*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D014611:Vaccination
D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral