c-fos expression induces bone tumors in transgenic mice.
The proto-oncogene c-fos has been isolated as the cellular homolog of the v-fos gene found in the osteosarcoma inducing FBR- and FBJ-murine sarcoma viruses (MSV). Expression of the c-fos gene in transgenic mice leads to the development of bone lesions of which about half progress to bone tumors mainly chondrosarcomas. The tumors display a strong preference for males and have a latency with a mean of 9.5 months. However, also mice without visible lesions develop bone tumors with the same sex preference and latency. These consequences of c-fos expression are independent of the chosen promoter but dependent on a replacement of 3' noncoding sequences of c-fos by a long terminal repeat (LTR) of the FBJ-MSV virus.
Rüther
U
U
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany.
Komitowski
D
D
Schubert
F R
FR
Wagner
E F
EF
D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes; D012091:Repetitive Sequences, Nucleic Acid; D009053:Sarcoma Viruses, Murine / Q000235:genetics; D012737:Sex Factors
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos