[Immunobiologic activity of Bordetella pertussis strains defective in various virulence factors].
The immunobiological properties of mutant strains, selectively deprived of certain antigens (hemagglutinin, B. pertussis toxin, dermonecrotic toxin, hemolysin, adenylate cyclase), have been studied with the aim of finding out the relationship between the presence of certain antigens in microbial strains and their protective properties. The results of these studies suggest that the protective potency of pertussis vaccine may be related to the presence of some antigenic substances, including those not pertaining to the known factors of virulence.
Smirnov
V D
VD
Chuprinina
R P
RP
Siundiukova
R A
RA
Maksiutov
R V
RV
D037361:Adenylate Cyclase Toxin; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology* / Q000472:pathogenicity; D006388:Hemagglutinins / Q000032:analysis / Q000276:immunology; D051379:Mice; D009154:Mutation; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000032:analysis / Q000276:immunology; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000032:analysis / Q000276:immunology
D037361:Adenylate Cyclase Toxin; D000942:Antigens, Bacterial; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin
Immunobiologicheskaia aktivnost' shtammov Bordetella pertussis, defektnykh po razlichnym faktoram virulentnosti.