How steroid hormones work.
Understanding how steroids work has led to improved comprehension of such derangements of hormonal regulation as testicular feminization. This knowledge has found practical application in the treatment of hormone-dependent cancers. Gene therapy, albeit still too primitive to correct steroid-response defects, promises to be a future mainstay of management.
Harrison
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RW
Division of Endocrinology and Metabolism, University of Arkansas College of Medicine, Little Rock.
Lippman
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SS
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D011519:Proto-Oncogenes / Q000187:drug effects; D011987:Receptors, Steroid / Q000032:analysis / Q000302:isolation & purification / Q000502:physiology*; D013256:Steroids / Q000494:pharmacology / Q000502:physiology*; D013329:Structure-Activity Relationship
D011987:Receptors, Steroid; D013256:Steroids