Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures.
In astrocytes grown in primary cultures from cerebral cortex of neonatal rats, alpha 1-adrenoceptors regulate the active uptake of glutamate followed by an activation of glutamic oxaloacetate transaminase (GOT; EC 2.6.1.1.) and a slight activation of glutamine synthetase (GS; EC 6.3.1.2.) activity. The beta-adrenoceptors regulate the active uptake of GABA, and this is followed by an activation of gamma-aminobutyric acid alpha-ketoglutarate transaminase (GABA-T; EC 2.6.1.19.). The data suggest that astrocyte adrenoceptors may modulate neurotransmitter induced neuronal excitability.
Hansson
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Institute of Neurobiology, University of Göteborg, Sweden.
Rönnbäck
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L
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism*; D001693:Biological Transport, Active; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D011941:Receptors, Adrenergic; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D001219:Aspartate Aminotransferases; D000612:4-Aminobutyrate Transaminase; D005974:Glutamate-Ammonia Ligase