Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.
The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a cloned cDNA for the androgen receptor, of somatic cell hybrid panels segregating portions of the X chromosome. A moderate-frequency HindIII RFLP has been found which should be useful in genetic linkage analysis of the various inherited forms of androgen insensitivity.
Brown
C J
CJ
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Goss
S J
SJ
Lubahn
D B
DB
Joseph
D R
DR
Wilson
E M
EM
French
F S
FS
Willard
H F
HF
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011944:Receptors, Androgen / Q000235:genetics*; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers; D011944:Receptors, Androgen