title: Clinical and serological outcome of genital herpes simplex virus (HSV) type 2 inoculation following oral HSV type 1 infection in guinea-pigs.
abstract: The clinical and serological outcome of genital herpes simplex virus type 2 (HSV-2) inoculation in animals previously orally infected with HSV type 1 was evaluated. A prior HSV-1 oral infection modified the genital HSV-2 infection so that only four of 18 (22%) animals were initially symptomatic although all but one animal shed HSV-2 from the cervicovaginal area for at least 5 days following inoculation. Three of four animals with symptomatic initial disease also developed recurrences, as did an additional six animals that did not manifest acute genital disease. Anti-glycoprotein gG-1 antibody was found in 17 of 18 animals with only an HSV-1 infection and anti-gG-2 antibody in all of nine animals with only an HSV-2 infection. Anti-gG-2 antibody was detected in eight of 17 animals with a prior HSV-1 infection following HSV-2 inoculation and one had an indeterminate response. Eight of these nine animals developed recurrent genital disease compared to one of eight that did not respond to gG-2 (P less than 0.006). Thus a prior oral HSV-1 infection modified both the initial presentation of HSV-2 infection and the HSV type-specific serological response.
authors.affiliation: James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
authors.forename: D I
authors.initials: DI
authors.lastname: Bernstein
authors.forename: F K
authors.initials: FK
authors.lastname: Lee
authors.forename: G
authors.initials: G
authors.lastname: Echler
authors.forename: A J
authors.initials: AJ
authors.lastname: Nahmias
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D006560:Herpes Labialis / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D018139:Simplexvirus / Q000502:physiology*; D014621:Vagina / Q000382:microbiology; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral