MIF-1 is active in a chronic stress animal model of depression.
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress. In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given. The tricyclic antidepressant imipramine (5 mg/kg) and low doses (0.1 and 1.0 mg/kg) of MIF-1 significantly increased activity and decreased defecation in an open field on day 21. No dose of naloxone (0.01-10.0 mg/kg) acted as an antidepressant. A high dose (10.0 mg/kg) of MIF-1 significantly increased the effects of chronic stress and produced hyperalgesia. Chronically-stressed rats were significantly more analgesic than controls. The results indicate that MIF-1 can act as an antidepressant in this model.
Pignatiello
M F
MF
Department of Psychology, University of New Orleans, LA 70148.
Olson
G A
GA
Kastin
A J
AJ
Ehrensing
R H
RH
McLean
J H
JH
Olson
R D
RD
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000209:etiology / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000627:therapeutic use; D009075:MSH Release-Inhibiting Hormone / Q000627:therapeutic use*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism*
D000928:Antidepressive Agents; D009270:Naloxone; D009075:MSH Release-Inhibiting Hormone; D007099:Imipramine