Pharmacokinetics of three different injectable zuclopenthixol preparations.
1. The zuclopenthixol concentrations in serum has been investigated in man and dog after injection of three different zuclopenthixol preparations. These were zuclopenthixol dihydrochloride in aqueous solution, zuclopenthixol acetate in oil and zuclopenthixol decanoate in oil. 2. The pharmacokinetic profiles of the three injectable zuclopenthixol preparations are very different. Maximum serum levels are obtained after about 1 hour for zuclopenthixol dihydrochloride, after 36 hours for zuclopenthixol acetate and after one week for zuclopenthixol decanoate. 3. The different pharmacokinetics of the three injectable zuclopenthixol preparations are reflected in their clinical properties.
Aaes-Jørgensen
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Department of Biochemistry, H. Lundbeck A/S, Copenhagen, Denmark.
D000328:Adult; D000368:Aged; D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D003006:Clopenthixol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013892:Thioxanthenes / Q000493:pharmacokinetics*
D014150:Antipsychotic Agents; D013892:Thioxanthenes; C060342:clopenthixol acetate ester; C029674:clopenthixol decanoate; D003006:Clopenthixol