Xylazine antinociception in mice: evidence for mediation by postsynaptic adrenoceptors.
The influence of 6-hydroxydopamine (6-OHDA) pretreatment on xylazine (XLZ)-induced antinociception was studied in mice using the writhing test (60 mg/kg acetic acid, ip, as the algogenic compound administered 10 min after 0.5 and 0.75 mg/kg XLZ, sc). 6-OHDA (100 mg kg-1 injection-1 administered ip on days 1, 3, 5, 7, 9 and 11 after birth) did not modify XLZ-induced antinociception, suggesting that this effect is mediated by postsynaptic alpha-2 adrenoceptors.
Naves
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Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Freire
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D000698:Analgesia; D000818:Animals; D006892:Hydroxydopamines / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects; D016627:Oxidopamine; D010147:Pain Measurement / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
D006892:Hydroxydopamines; D011942:Receptors, Adrenergic, alpha; D013843:Thiazines; D014991:Xylazine; D016627:Oxidopamine