M-signal hypothesis--metabolic modulation of membrane functions in rat brain.
1. Monoamine oxidase (amine: oxygen oxidoreductase [deaminating], EC 1.4.3.4) (MAO) and Na+/K+ ATPase (Na+/K+-ATPase, Mg2+-dependent ATP phosphohydrolase, EC 3,1,6,3) showed reciprocal relationship in their activity patterns during experimentally perturbed situations in vivo as well as in vitro. 2. M-signal hypothesis is proposed, which attempts at explaining the regulation of plasma membrane function by the intermediate of metabolic processes in the cell. This metabolic intermediate referred to as M-signal exercise its influence on the plasma membrane Na+/K+ ATPase which is responsible for the uptake process.
Mayanil
C S
CS
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Baquer
N Z
NZ
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002395:Catecholamines / Q000096:biosynthesis / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002395:Catecholamines; D008995:Monoamine Oxidase; D000254:Sodium-Potassium-Exchanging ATPase