title: Methodological considerations in cognitive disorders or: "the baby needs enough bath water".
abstract: Establishing treatment efficacy for neuropsychiatric disorders is an often protracted process due to vagaries of symptoms, course, and probably the inherent variability of the central nervous system. No single study design is likely to be definitive. Thorough evaluation of intracranial drug infusion for illnesses such as Alzheimer's Disease will require extended, multidisciplinary work before true evaluation can confidently be made.
authors.affiliation: John Douglas French Center, Los Alamitos, CA 90720.
authors.forename: S
authors.initials: S
authors.lastname: Read
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D007260:Infusion Pumps
chemical_list: D001626:Bethanechol Compounds; D018723:Bethanechol