Bradykinin-induced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate.
1. The effects of inhaled nedocromil sodium and sodium cromoglycate on bradykinin-induced bronchoconstriction have been studied in a double-blind, placebo controlled study, in eight mild asthmatic subjects. 2. The subjects attended on four occasions. Fifteen minutes after drug pre-treatment a bradykinin challenge was performed. Increasing concentrations were inhaled until a greater than 40% fall in expiratory flow at 30% of vital capacity from a partial flow volume manoeuvre (V p30) was demonstrated. 3. Inhaled bradykinin (0.06-8.0 mg ml-1) caused dose-related bronchoconstriction with the geometric mean cumulative dose causing a 40% fall in V p30 (PD40) of 0.035 (95% CI: 0.02-0.07) mumol, after placebo inhalation, which was similar to that measured before the trial (0.04: 0.02-0.09 mumol). 4. Both nedocromil sodium (4 mg) and sodium cromoglycate (10 mg) gave significant protection (P less than 0.05) against bradykinin-induced bronchoconstriction (PD40 0.37: 0.19-0.72 mumol after nedocromil sodium and 0.22: 0.11-0.49 after sodium cromoglycate). 5. Since bradykinin-induced bronchoconstriction is probably neurally mediated we conclude that both nedocromil sodium and sodium cromoglycate have an action on neural pathways which may be useful in the control of asthma symptoms.
Dixon
C M
CM
Department of Thoracic Medicine, Brompton Hospital.
Barnes
P J
PJ
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001249:Asthma / Q000503:physiopathology; D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001993:Bronchodilator Agents; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology*; D012129:Respiratory Function Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001993:Bronchodilator Agents; D015363:Quinolones; D017835:Nedocromil; D004205:Cromolyn Sodium; D001920:Bradykinin