High resolution 1H NMR study of the solution structure of the S4 segment of the sodium channel protein.
A peptide (S4) of the rat brain sodium channel has been synthesized, studied by high-resolution NMR and its secondary structure modelled by distance geometry and restrained molecular dynamics techniques.
Mulvey
D
D
Department of Biochemistry, University of Oxford, England.
King
G F
GF
Cooke
R M
RM
Doak
D G
DG
Harvey
T S
TS
Campbell
I D
ID
D000595:Amino Acid Sequence; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008565:Membrane Proteins / Q000302:isolation & purification; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis; D011487:Protein Conformation; D015222:Sodium Channels / Q000032:analysis*
D008565:Membrane Proteins; D010446:Peptide Fragments; D015222:Sodium Channels; D006859:Hydrogen