title: Contribution of peripheral opioid receptors to the trimebutine-induced contractions of the proximal colon in anesthetized rats.
abstract: In this study we investigated the involvement of opioid receptors in the contractile response to trimebutine using with the proximal colon of anesthetized rats. Trimebutine (3 mg/kg i.v.) enhanced spontaneous contractions of the proximal colon in anesthetized rats. The contractile response was partially inhibited by intravenous administration of an opioid antagonist, naloxone at 1 approximately 30 micrograms/kg, but was hardly depressed by intracisternal administration of naloxone (30 micrograms/kg). Morphine (30 micrograms/kg i.v.) evoked colonic contractions which were abolished by intravenous naloxone (30 micrograms/kg). These results suggest that the colonic contractions evoked by trimebutine in anesthetized rats are, in part, mediated by peripheral opioid receptors.
authors.affiliation: Biological Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Ikezawa
authors.forename: H
authors.initials: H
authors.lastname: Tamaki
mesh_terms: D000758:Anesthesia; D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D014287:Trimebutine / Q000494:pharmacology*
chemical_list: D001565:Benzoates; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D014287:Trimebutine