title: Poliovaccine virus in the cerebrospinal fluid after oral polio vaccination.
abstract: In February-March 1985 an oral poliovirus vaccine campaign was launched in Finland in a population vaccinated earlier with inactivated poliovaccine. During this campaign a strain of poliovirus was isolated from the cerebrospinal fluid (CSF) of a 7-year-old girl 34 days after she had received oral poliovirus vaccine. She had long-lasting headache, vomiting and fever but no paralysis. This case demonstrates that poliovaccine virus can invade the central nervous system even after a complete course of inactivated poliovirus vaccine if the inactivated vaccine has been poorly antigenic against one of the three types of virus.
authors.affiliation: Department of Pediatrics, University of Oulu, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Rantala
authors.forename: M
authors.initials: M
authors.lastname: Uhari
authors.forename: H
authors.initials: H
authors.lastname: Tuokko
authors.forename: M
authors.initials: M
authors.lastname: Stenvik
authors.forename: L
authors.initials: L
authors.lastname: Kinnunen
mesh_terms: D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002648:Child; D005260:Female; D006801:Humans; D017955:Poliovirus / Q000302:isolation & purification*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D014611:Vaccination
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral