Ultrastructural changes in rat Clara cells induced by bis(4-amino-3-methylcyclohexyl)methane.
Repeated oral administration of bis(4-amino-3-methylcyclohexyl)methane to rats induced unusual ultrastructural changes in Clara cells of the bronchiolar epithelium, involving marked accumulation of electron-dense inclusion bodies with a lamellar structure in the cytoplasm. The appearance of the inclusion bodies was speculated to result from accumulation of complexes formed between the agent and phospholipids within lysosomes, a condition known as drug-induced lipidosis. This finding appeared noteworthy, since it might reflect high potential for metabolism of xenobiotic compounds in Clara cells.
Ohshima
S
S
Second Department of Pathology, Saitama Medical School, Japan.
Shimizu
Y
Y
Shibata
T
T
D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000648:ultrastructure*; D003514:Cyclohexylamines / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D002479:Inclusion Bodies / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344
D003514:Cyclohexylamines; C026295:bis(4-amino-3-methylcyclohexyl)methane