title: Adrenergic mediated phosphatidylinositol metabolism is modulated by epileptic discharges in human neocortex.
abstract: Adrenergic mediated phosphatidylinositol (PI) hydrolysis was measured in tissues obtained from 21 patients immediately following surgery for focal epilepsy. Accumulation of [3H]inositol monophosphate (IP1) was significantly reduced (21%, P less than 0.01) in actively spiking neocortex (n = 15) versus samples from non-spiking regions (n = 9). Epileptic discharges may blunt alpha 1-adrenoceptor stimulated transmembrane signalling in human neocortical epileptic foci.
authors.affiliation: Montreal Neurological Institute, McGill University, Que, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Dubeau
authors.forename: A L
authors.initials: AL
authors.lastname: Sherwin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D004837:Epinephrine