title: A unique verrucous anogenital tumor associated with type 6b-related human papillomavirus.
abstract: Multiple dark brown papillomatous tumors, showing some histological features of verrucous carcinoma or giant condyloma, developed mainly in the anogenital region of a Japanese woman. The tumors first appeared when she was 51 years old and annoyed her for over 20 years with several recurrences without any frank malignant transformation, after surgery. Immunohistochemically, papillomavirus genus-specific antigen was demonstrated only in small foci of the lesions resected at first operation. Southern blot analysis revealed human papillomavirus type 6b-related DNA in a surgically resected specimen. The possible role of the human papillomavirus in the genesis of this unique tumor is discussed.
authors.affiliation: Pathology Division, National Cancer Center, Research Institute, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Yutsudo
authors.forename: S
authors.initials: S
authors.lastname: Ikekawa
authors.forename: K
authors.initials: K
authors.lastname: Hayasaka
authors.forename: K
authors.initials: K
authors.lastname: Ishihara
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: Y
authors.initials: Y
authors.lastname: Shimosato
authors.forename: Y
authors.initials: Y
authors.lastname: Tsunokawa
authors.forename: M
authors.initials: M
authors.lastname: Terada
mesh_terms: D000368:Aged; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology; D001005:Anus Neoplasms / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D015139:Blotting, Southern; D002291:Carcinoma, Papillary / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D015344:DNA Probes, HPV / Q000032:analysis; D005260:Female; D005833:Genital Neoplasms, Female / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000276:immunology / Q000473:pathology
chemical_list: D000952:Antigens, Polyomavirus Transforming; D015344:DNA Probes, HPV