title: [The trial preparation of attenuated live hepatitis A vaccine].
abstract: The experimental attenuated live hepatitis A vaccine has been prepared in KMB17 human fetal lung diploid cells with the HAV variant H2M20K5 (32 degrees C). No extraneous agent was detected in the vaccine, which had a titer of 10(6.5) TCID50/ml. Twelve monkeys vaccinated intravenously or subcutaneously were found to have no significant clinical hepatitis but with anti-HAV antibody in all cases. Thus the safety and immunogenicity of the vaccine were evidenced in monkeys and it is necessary to investigate the trial vaccination further in a few susceptible individuals.
authors.forename: D X
authors.initials: DX
authors.lastname: Dong
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D006506:Hepatitis A / Q000517:prevention & control; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines