[Mechanism of the inhibition of proliferation of hapten-modified human and mouse leukemic cells by hapten-specific T-suppressor factor].
T-suppressor-inducer and T-suppressor-effector hybridoma supernatants both regulating the DTH reaction intensity triggered by trinitrophenyl-sulphonic acid (TNPSA) or antigen-dependent proliferation of mice lymph node cells to trinitrophenylated bovine serum albumin, possess and ability to inhibit proliferation of TNPSA-modified human and mice leukaemic cells. This effect is specific, and is caused from antigen binding. This effect is specific, and is caused from antigen binding, idiotype positive T-suppressor factors and is based on a cyclic adenosine monophosphate increase of the concentration in target cells.
Chernousov
A D
AD
Medunitsyn
N V
NV
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D000242:Cyclic AMP / Q000032:analysis; D006241:Haptens; D006801:Humans; D006825:Hybridomas; D007938:Leukemia / Q000276:immunology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D006241:Haptens; D000242:Cyclic AMP
Mekhanizm podavleniia proliferatsii modifitsirovannykh gaptenom kletok leĭkoza cheloveka i myshi gaptenspetsificheskimi faktorami T-supressorov.