Increased peripheral alpha 1-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat.
The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional alpha 1-adrenoceptors in the rat blood vessels become supersensitive after long-term treatment with thioridazine.
Cuffí
M L
ML
Departament de Farmacologia i Psiquiatria, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Vila
E
E
Badia
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D014991:Xylazine; D008729:Methoxamine; D013881:Thioridazine