alpha-Difluoromethylornithine (DFMO) disturbed the sensorimotor functional recovery from a sciatic lesion.
The effects of inhibition of polyamine synthesis on the motor and sensory functional neural recovery after a sciatic crush lesion was studied by measuring sensory and motor function of a crushed sciatic nerve after daily exposure to alpha-difluoromethylornithine (DFMO). DFMO increased the time needed for functional motor recovery by 13% in the toe-spread test when the lesion was about 20 mm proximal to the target muscle. DFMO reduced the rate of sensory axonal elongation by 24% in the pinch-test.
Kauppila
T
T
Department of Physiology, University of Helsinki, Finland.
Stenberg
D
D
D000818:Animals; D000518:Eflornithine / Q000494:pharmacology*; D005260:Female; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D011073:Polyamines / Q000037:antagonists & inhibitors; D051381:Rats; D012584:Sciatic Nerve / Q000503:physiopathology*
D011073:Polyamines; D000518:Eflornithine