Primary and transplantable hepatomas induced by aflatoxin B1 in hypothyroid rats.
The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung metastases were observed. The level of GGTP in serum and liver paralleled the advancement of morphological hepatic lesions, and the activity of serum GGTP in hypothyroid bearers of the transplantable hepatoma was lower in females than in males. It was concluded that the lack of thyroid hormones during the latency period of primary and transplantable hepatomas is decisive for delayed AFB1 carcinogenesis.
Bednarz
W
W
First Chair and Clinic of Surgery, Medical Academy, Wroclaw, Poland.
D000310:Adrenal Gland Neoplasms / Q000556:secondary; D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D002908:Chronic Disease; D006965:Hyperplasia; D007037:Hypothyroidism / Q000150:complications*; D007680:Kidney Neoplasms / Q000556:secondary; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D009368:Neoplasm Transplantation; D009929:Organ Size; D011230:Precancerous Conditions; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000348:Aflatoxins; D016604:Aflatoxin B1; D005723:gamma-Glutamyltransferase