[Influence of hepatic ischemia on liver regeneration following hepatectomy, with special reference to the therapeutic choice for ruptured hepatoma].
The influence of partial hepatic ischemia (32%) prior to partial hepatectomy (68%) has been studied in the rat. 3H-thymidine incorporation into the hepatic DNA was significantly suppressed in both 20 min and 30 min ischemia depressed the survival following partial hepatectomy (p less than 0.001). Three cases of ruptured hepatocellular carcinomas were treated: one case by emergency hepatectomy, and two cases by hepatectomy following TAE. Hepatic insufficiency and post-operative death occurred to only the case given an emergency hepatectomy. Thus, it is felt that a ruptured hepatoma should first be treated by TAE and then surgically resected.
Miyazaki
M
M
1st Dept. of Surgery, School of Med., Chiba Univ.
Udagawa
I
I
Koshikawa
H
H
Itoh
H
H
Kanno
Y
Y
Teramoto
O
O
Nakajima
T
T
Kaiho
T
T
Kimura
F
F
Matsumoto
J
J
D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000601:surgery / Q000628:therapy*; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D007511:Ischemia / Q000601:surgery; D008099:Liver / Q000098:blood supply; D008113:Liver Neoplasms / Q000601:surgery / Q000628:therapy*; D008114:Liver Neoplasms, Experimental / Q000601:surgery; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012422:Rupture, Spontaneous; D012771:Shock, Hemorrhagic / Q000601:surgery*
D008937:Mitomycins; D016685:Mitomycin