Acceleration of B-lymphoid tumorigenesis in E mu-myc transgenic mice by v-H-ras and v-raf but not v-abl.
Emu-myc transgenic mice constitutively express the c-myc oncogene from before birth, but their inexorable development of B-lymphoid tumors appears to require rare spontaneous alterations within B-lineage cells. To determine whether other oncogenes can cooperate with myc to induce B-lymphoid transformation, we infected neonatal Emu-myc mice and normal littermates with helper-free retroviruses bearing the v-H-ras, v-raf, or v-abl oncogene. The v-H-ras and the v-raf oncogene dramatically accelerated Emu-myc pre-B-lymphoma onset, whereas v-abl did not, despite the increased numbers of presumptive target pre-B cells in Emu-myc mice. These results imply that v-H-ras and v-raf synergize with deregulated myc expression to transform pre-B cells, while v-abl apparently does not.
Langdon
W Y
WY
Walter & Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Australia.
Harris
A W
AW
Cory
S
S
D000818:Animals; D001402:B-Lymphocytes; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D011905:Genes, ras; D008223:Lymphoma / Q000209:etiology*; D051379:Mice; D008822:Mice, Transgenic; D027384:Oncogene Proteins v-raf; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D012191:Retroviridae Proteins / Q000235:genetics*; D014170:Transformation, Genetic; D014764:Viral Proteins / Q000235:genetics*
D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D012191:Retroviridae Proteins; D014764:Viral Proteins; D027384:Oncogene Proteins v-raf; D004262:DNA Restriction Enzymes