T-cell antigen receptor beta-chain variable region families: a study of their distribution in normal and reactive tissues.
The beta chain of the T-cell antigen receptor is constructed using a variable region gene from one of approximately 20 variable gene families. Antibodies that react with the products of these gene families have been used to demonstrate clonal proliferation of T cells. Here, we describe the expression of two beta-chain variable region families in normal and reactive lymphoid tissues. In all the tissues studied, expression was scattered throughout the T-cell areas, without any clustering of expression.
Clark
D M
DM
Department of Pathology, St Mary's Hospital Medical School, London, U.K.
Boylston
A W
AW
D000911:Antibodies, Monoclonal; D002675:Child, Preschool; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D007135:Immunoglobulin Variable Region; D007223:Infant; D007421:Intestine, Small / Q000032:analysis; D008198:Lymph Nodes / Q000032:analysis; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D013154:Spleen / Q000032:analysis; D013950:Thymus Gland / Q000032:analysis
D000911:Antibodies, Monoclonal; D007135:Immunoglobulin Variable Region; D011948:Receptors, Antigen, T-Cell