title: [Characteristics of inserted mutations obtained in the P-M hybrid dysgenesis system in the 9F12-10A7 region of the Drosophila melanogaster X-chromosome].
abstract: 19 new mutations in the 9F12-10A7 region of Drosophila melanogaster X chromosome was obtained in the system of P-M hybrid dysgenesis. They appeared to be lethals, as judged from viability of homo- or hemizygous females. In situ hybridization of P DNA with polytene chromosomes revealed P-element insertion in the 10A1-2 band in the majority of the mutants. As a result of complementation analysis, all these mutations were localized at previously known loci: l(1)BP1, l(1)BP5, l(1)BP8, l(1)BP7. No insertion mutations were found at the vermilion locus. This can imply for non-random distribution of insertion mutations in the region studied. Further comparison of these mutations with previously EMS-induced ones revealed that insertion mutations are predominantly hypomorph lethals which do not influence the viability, morphology and fertility of homozygous males and females, but drastically reduce viability of hemizygous females.
authors.forename: G V
authors.initials: GV
authors.lastname: Pokholkova
authors.forename: I V
authors.initials: IV
authors.lastname: Solov'eva
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D009154:Mutation; D014960:X Chromosome
chemical_list: D004251:DNA Transposable Elements
vernacular_title: Kharakteristika insertsionnykh mutatsiĭ, poluchennykh v sisteme P-M gibridnogo disgeneza, v raĭone 9F12-10A7 X-khromosomy Drosophila melanogaster.