Herpes zoster in an adult recipient of live attenuated varicella vaccine.
A healthy 30-y-old female physician who was immunized with two doses of live attenuated varicella vaccine developed a localized case of zoster involving the right T8-10 dermatomes 36 mo after vaccination. The virus isolated from her rash was an unusual wild-type of varicella-zoster virus. After immunization she developed detectable antibodies to varicella-zoster virus, but antibodies were no longer detectable after 20 mo. Six months before development of zoster, she was exposed to a patient with varicella; however, she did not develop a clinical illness although she again became seropositive. To date, this is the only reported case of zoster among 187 healthy adult vaccinees.
Hammerschlag
M R
MR
Department of Pediatrics, SUNY Health Science Center, Brooklyn, New York.
Gershon
A A
AA
Steinberg
S P
SP
Clarke
L
L
Gelb
L D
LD
D000328:Adult; D019433:Chickenpox Vaccine; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006562:Herpes Zoster / Q000209:etiology*; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015183:Restriction Mapping; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects*
D019433:Chickenpox Vaccine; D004279:DNA, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines