title: Opioid peptides. Partially modified retro-inverso dermorphin analogues. XIII.
abstract: We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) related peptides. The drastic loss of mu-receptor affinity following introduction of retro-inverso peptide bond between Phe1-D-Ala2 in the new peptide analogues, emphasized the importance of this backbone in the dermorphin peptides.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marastoni
authors.forename: G
authors.initials: G
authors.lastname: Balboni
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
authors.forename: S
authors.initials: S
authors.lastname: Salvadori
authors.forename: P A
authors.initials: PA
authors.lastname: Borea
authors.forename: L
authors.initials: L
authors.lastname: Uccelli
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004723:Endorphins / Q000138:chemical synthesis*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis*; D018847:Opioid Peptides; D010084:Oxidation-Reduction; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism
chemical_list: D004723:Endorphins; D004745:Enkephalins; D009842:Oligopeptides; D018847:Opioid Peptides; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C030058:dermorphin