Distribution of injected monoclonal antibody in lymphoma-infiltrated spleen.
Specific and non-specific antibody was injected into mice with lymphoma-infiltrated spleens in order to assess the distribution with both time and with extent of tumour infiltration. The specific antibody (MRC OX7) bound to the Thy 1.1 antigen on the lymphoma cells (A120). There was evidence that the diffusion of MRC OX7 deeply into the tumour was hindered by competitive binding to the tumour cells immediately surrounding the supplying blood vessels. In some circumstances this situation persisted to 24 h, after which time the antibodies were being cleared from the host in significant amounts.
Cobb
L M
LM
Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, U.K.
Butler
S
S
Humphreys
J
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000912:Antibodies, Neoplasm / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000954:Antigens, Surface / Q000276:immunology; D001345:Autoradiography; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology*; D051379:Mice; D013154:Spleen / Q000473:pathology*; D013601:T-Lymphocytes; D018800:Thy-1 Antigens; D013997:Time Factors
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000954:Antigens, Surface; D018800:Thy-1 Antigens