Glucuronides in mussel Mytilus galloprovincialis as a possible biomonitor of environmental carcinogens.
1. The in vitro incubation of mussel digestive gland with 1 mM aminofluorene resulted in the formation of glucuronides that (a) became mutagenic with carp liver S9, and (b) liberated S9-dependent mutagenic aglucones after beta-glucuronidase treatment. 2. Natural populations of mussels from unpolluted and polluted sites, as well as mussels exposed to 3 ppm of aminofluorene or to used engine oil, did not accumulate detectable amounts of premutagens, mutagens, or mutagenic glucuronides/aglucones either in digestive gland tissue or in shell-cavity water. 3. The mutagenicity testing of mussel's glucuronides/aglucones does not seem to be useful as a biomonitor of environmental carcinogens.
Kurelec
B
B
Center for Marine Research Zagreb, Rudjer Bosković Institute, Yugoslavia.
Krca
S
S
D000818:Animals; D049872:Bivalvia; D002274:Carcinogens, Environmental / Q000032:analysis* / Q000633:toxicity; D004784:Environmental Monitoring; D005965:Glucuronates / Q000032:analysis*; D005966:Glucuronidase / Q000494:pharmacology; D009152:Mutagenicity Tests
D002274:Carcinogens, Environmental; D005965:Glucuronates; D005966:Glucuronidase