Proopiomelanocortin-derived peptides in mice with motoneurone disease.
beta-Endorphin and alpha-melanotropin immunoreactivity was detected in motor nerves in histological sections of murine skeletal muscle, using the peroxidase-antiperoxidase technique. In mice of the wobbler strain, which can inherit motoneurone disease, a significantly higher proportion of the intramuscular nerves in soleus, extensor digitorum longus and diaphragm muscles of the diseased mice were immunoreactive than in the corresponding muscles of their healthy littermates.
Hughes
S
S
Department of Physiology, Medical School, University of Birmingham, U.K.
Smith
M E
ME
D000375:Aging / Q000378:metabolism; D000818:Animals; D007124:Immunoenzyme Techniques; D051379:Mice; D009046:Motor Neurons / Q000378:metabolism*; D009411:Nerve Endings / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D000521:alpha-MSH / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism*
D000521:alpha-MSH; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin