title: Activation of the immune coagulation system by murine hepatitis virus strain 3.
abstract: Viral infections result in alterations in hemostasis and coagulation. It has previously been shown that susceptibility to murine hepatitis virus strain 3 (MHV-3), a coronavirus, correlates directly with the spontaneous, T lymphocyte-instructed expression of a procoagulant monokine that exhibits prothrombin-cleaving activity (procoagulant activity [PCA]). A biologic role for PCA in the pathogenesis of MHV-3 infection is suggested by results of in vivo microscopic observations made during acute MHV-3 infection. Recently, it has been demonstrated that prostaglandin E2 abrogates the induction of PCA by MHV-3 both in vivo and in vitro and prevents hepatic necrosis and the associated microcirculatory changes. These data suggest that MHV-3 induces cellular injury through the activation of the coagulation cascade and provide further evidence for a role for PCA in the pathogenesis of MHV-3 infection.
authors.affiliation: University of Toronto, Ontario, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Levy
authors.forename: M
authors.initials: M
authors.lastname: Abecassis
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D006524:Hepatitis, Viral, Animal / Q000097:blood* / Q000276:immunology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008833:Microcirculation; D006517:Murine hepatitis virus / Q000276:immunology; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D011453:Prostaglandins; C045071:leukocyte procoagulant activity; C045072:macrophage procoagulant activity