Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
The enantiomers of 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8- amine (1a) were prepared and tested for their actions on central dopamine and serotonin (5-HT) receptors. The dopaminergic effects were shown to reside in the (1)-R enantiomer. It was shown that compound 1a and its (+)-R enantiomer possess potent central 5-HT1A receptor stimulating properties.
Wikström
H
H
Department of Pharmacology, University of Göteborg, Sweden.
Andersson
B
B
Svensson
A
A
Humber
L G
LG
Asselin
A A
AA
Svensson
K
K
Ekman
A
A
Carlsson
A
A
Nilsson
I
I
Chidester
C
C
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D015259:Dopamine Agents / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D007536:Isomerism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D013329:Structure-Activity Relationship
D015259:Dopamine Agents; D007211:Indoles; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; C061237:6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz(e)indol-8-amine; D012110:Reserpine