title: [The ectophosphatase activity of cultured endothelial cells of calf aorta and the effect of drugs on ecto-ATPase].
abstract: Cultivated endothelial cells of calf aorta (line BKEz-7) possess an effective ectophosphatase system (enzyme activities: ATPase 38.0 +/- 10.2; ADPase 9.2 +/- 4.2; 5'-nucleotidase 4.1 +/- 2.6 fmol/cell.min). Drugs with central depressive activity such as promazine, chlorpromazine, and meprobamate inhibit the activity of the ecto-ATPase. A possible connection between the inhibitory activity on the ecto-ATPase and their central depressive effects is discussed.
authors.affiliation: Sektion Pharmazie, Ernst-Mortiz-Arndt-Universität Greifswald, DDR.
authors.forename: M
authors.initials: M
authors.lastname: Melzig
authors.forename: H
authors.initials: H
authors.lastname: Michalski
authors.forename: E
authors.initials: E
authors.lastname: Teuscher
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000201:enzymology; D002417:Cattle; D004730:Endothelium, Vascular / Q000166:cytology / Q000201:enzymology*; D009124:Muscle Proteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D015720:5'-Nucleotidase; D000251:Adenosine Triphosphatases; C027201:ectoATPase
vernacular_title: Untersuchungen zur Ektophosphatase-Aktivität kultivierter Kälberaorten-endothelzellen und zur Beeinflussung der Ekto-ATPase durch Pharmaka.