title: Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells.
abstract: Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with beta-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.
authors.affiliation: Department of Pediatrics, University of Toronto, Ontario, Canada.
authors.forename: R D
authors.initials: RD
authors.lastname: Pearce
authors.forename: D
authors.initials: D
authors.lastname: Kiehm
authors.forename: D T
authors.initials: DT
authors.lastname: Armstrong
authors.forename: P B
authors.initials: PB
authors.lastname: Little
authors.forename: J W
authors.initials: JW
authors.lastname: Callahan
authors.forename: L R
authors.initials: LR
authors.lastname: Klunder
authors.forename: J T
authors.initials: JT
authors.lastname: Clarke
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D002678:Chimera; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000276:immunology*; D006041:Goats; D018380:Hematopoietic Stem Cell Transplantation; D007108:Immune Tolerance; D008099:Liver / Q000196:embryology*; D016031:Liver Transplantation; D008297:Male; D008363:alpha-Mannosidosis / Q000628:therapy