L-ascorbic acid produces hypoglycaemia and hyperinsulinaemia in anaesthetized rats.
L-Ascorbic acid (Vitamin C) produced a marked reduction in the blood glucose concentration following intravenous injection (20-100 mg kg-1) to anaesthetized rats. This hypoglycaemic effect was accompanied by an increase in plasma insulin concentration. D-ascorbic acid produced a similar hypoglycaemic effect.
Cheng
J T
JT
Department of Pharmacology, College of Medicine, National Cheng Kung University, Taiwan, Republic of China.
Hsieh-Chen
S C
SC
Tsai
C L
CL
D000758:Anesthesia; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D001205:Ascorbic Acid