[Catecholamine complex-adrenoreactive system of various subtypes in various forms of bronchial asthma in children].
During the acute period of diverse forms of bronchial asthma in children the following alterations were detected in catecholamine metabolism and in various subtypes of the adrenoreactive system: an increase in urinary excretion of catecholamines, especially of adrenaline, as well as activation of catechol-O-methyl transferase; a decrease (or even absence) of beta 2-adrenoreactive system sensitivity, a decrease in beta 1-reactivity, while sensitivity of alpha 1-adrenoreactive system was increased (in the infectious-allergic form of the disease) and alpha 2-reactivity was unaltered. The uncoupling between catecholamines and various subtypes of the adrenoreactive system appears to occur during the acute period of bronchial asthma.
Kulinskiĭ
V I
VI
Chesmochakova
E I
EI
D000293:Adolescent; D001249:Asthma / Q000201:enzymology / Q000378:metabolism* / Q000652:urine; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D002395:Catecholamines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002648:Child; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D002394:Catechol O-Methyltransferase
Kompleks katekholaminy - adrenoreaktivnye sistemy raznnykh podtipov pri razlichnykh formakh bronkhial'noĭ astmy u deteĭ.