title: Alveolar rhabdomyosarcoma metastatic to the ovary. A report of two cases and a discussion of the differential diagnosis of small cell malignant tumors of the ovary.
abstract: Two young women with alveolar rhabdomyosarcoma metastatic to the ovary are reported. In each case, the ovarian involvement was detected within a few weeks of the discovery of a soft tissue mass by the patient. Symptoms attributable to the ovarian tumor dominated the initial clinical picture in one case. In the other case, the soft tissue mass was not appreciated by the treating physicians until after the diagnosis of rhabdomyosarcoma had been established by examination of the ovarian tumor. The ovarian tumor was unilateral in one case and bilateral in the other. One primary site was the right foot and the other primary site was the left forearm. These cases illustrate that metastatic alveolar rhabdomyosarcoma rarely enters into the differential diagnosis of a small cell malignant tumor of the ovary. Both patients experienced progression of their disease and died, despite aggressive chemotherapy, within 1 year of presentation.
authors.affiliation: Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
authors.forename: R H
authors.initials: RH
authors.lastname: Young
authors.forename: R E
authors.initials: RE
authors.lastname: Scully
mesh_terms: D000293:Adolescent; D000328:Adult; D018288:Carcinoma, Small Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005534:Foot Diseases / Q000473:pathology*; D005542:Forearm; D006801:Humans; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000473:pathology*