Effect of gamma-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach.
The effect of gamma-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.
Guo
Y S
YS
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
Thompson
J C
JC
Singh
P
P
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013270:Stomach / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005755:Gastrins; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D001839:Bombesin