Localization of calcitonin gene-related peptide and its receptors in a striated muscle.
The distribution of calcitonin gene-related peptide (CGRP) and its binding sites in the bulbocavernosus, a striated muscle, are reported. We used immunohistochemistry and [125I]CGRP autoradiography. The pattern of [125I]CGRP binding was restricted to a discrete band that coincides with the distribution of end-plates in this muscle as determined by CGRP immunohistochemistry and acetylcholinesterase staining. CGRP has been shown to increase the level of acetylcholine receptor (AChR) alpha-subunit mRNA. The role of CGRP as the endogenous factor by which motoneurons regulate the expression of junctional AChR is discussed.
Popper
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Department of Anatomy, UCLA School of Medicine 90024.
Micevych
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PE
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009045:Motor Endplate / Q000378:metabolism*; D009046:Motor Neurons / Q000166:cytology / Q000378:metabolism*; D009132:Muscles / Q000294:innervation* / Q000378:metabolism; D009469:Neuromuscular Junction / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface; D015740:Calcitonin Gene-Related Peptide