Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice.
Two lines of E alpha d-expressing NOD mice were established by continuously backcrossing [E alpha d B6 transgenic mice x NOD] F1 to parental NOD or directly microinjecting the E alpha d gene into fertilized NOD eggs. Similarly, A beta k-expressing transgenic NOD mice were produced. Subsequent histological examination of pancreatic tissues revealed that autoimmune insulitis was prevented in E alpha d backcross and transgenic mice but not in A beta k transgenic mice.
Uehira
M
M
Shionogi Research Laboratory, Shionogi Co. Ltd, Osaka, Japan.
Uno
M
M
Kürner
T
T
Kikutani
H
H
Mori
K
K
Inomoto
T
T
Uede
T
T
Miyazaki
J
J
Nishimoto
H
H
Kishimoto
T
T
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D003433:Crosses, Genetic; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic
D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen