FeLV-FAIDS-induced immunodeficiency syndrome in cats.
Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).
Mullins
J I
JI
Department of Cancer Biology, Harvard University School of Public Health, Boston, MA 02115.
Hoover
E A
EA
Overbaugh
J
J
Quackenbush
S L
SL
Donahue
P R
PR
Poss
M L
ML
D000163:Acquired Immunodeficiency Syndrome; D000818:Animals; D002371:Cat Diseases / Q000276:immunology* / Q000382:microbiology; D002415:Cats; D004195:Disease Models, Animal; D005814:Genes, Viral; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D007938:Leukemia / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D005256:Leukemia Virus, Feline / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*