title: [Two cases of scleroderma associated with vibration syndrome].
abstract: Case 1, a 49-year-old male who had been engaged in repair and reclamation of automobile tires, developed symptoms of vibration syndrome (Raynaud's phenomenon, numbness of both hands, tinnitus and impaired hearing) after some 30 years' use of a grinder and impact wrench. Two years thereafter, multiple sclerodermic lesions appeared over the trunk, upper extremities, and thighs; these disappeared about 2 years later. Histologically, hyperplasia and nodular swelling of collagen bundles were present in the dermis. An immunological study showed the serum to be positive for anti-centromere antibody, but no visceral lesions were demonstrable. This case corresponded to generalized morphea. Case 2, a 53-year-old male, developed symptoms of vibration syndrome (Raynaud's phenomenon, numbness of both hands, impaired hearing and arthralgia) after 25 years' use of a jack hammer in a quarry. Thereafter, sclerodermic changes of the forearms, lower legs, face and abdomen occurred with an associated sclerodactyly. Histological examination of involved skin revealed diffuse hyperplasia and homogenization of collagen bundles throughout the entire thickness of the dermis. These findings, together with serum positivity for anti-RNP antibody and dilation of the lower portion of the esophagus, led us to a diagnosis of progressive systemic sclerosis. We inferred that the vibration syndrome in the present cases might be related etiologically to these forms of scleroderma.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Kawabe
authors.forename: T
authors.initials: T
authors.lastname: Yasue
authors.forename: M
authors.initials: M
authors.lastname: Yuguchi
authors.forename: I
authors.initials: I
authors.lastname: Yoshida
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D002503:Centromere / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D011928:Raynaud Disease / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology*; D014732:Vibration / Q000009:adverse effects*
chemical_list: D001323:Autoantibodies