[The role of cGMP in extinguishing the reactions of identified neurons in the edible snail to acetylcholine].
Possible role of cGMP is studied in control of extinction of snail neurones RPa4, RPa3 and LPa3 reactions to acetylcholine (ACh), applied rhythmically to neurone soma by means of microiontophoresis. It is shown that guanylate cyclase activators which raise the cGMP level in the cell--Na nitroprusside and Na azide (5,10(-4)-10(-3) mol/l)--intensify at extracellular application the extinction of inward transmembrane current and membrane depolarization in response to ACh. Suggestion is made about participation of cGMP-dependent phosphorylation of membrane proteins in control of the development rate, depth and duration of neurone cholinoreceptors short-term plasticity.
Pivovarov
A S
AS
Drozdova
E I
EI
Kotliar
B I
BI
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001386:Azides / Q000494:pharmacology; D006152:Cyclic GMP / Q000502:physiology*; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D006162:Guanylate Cyclase / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology; D019810:Sodium Azide; D013997:Time Factors
D001386:Azides; D011950:Receptors, Cholinergic; D009599:Nitroprusside; D019810:Sodium Azide; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D000109:Acetylcholine
Rol' tsGMF v ugashenii reaktsiĭ identifitsirovannykh neĭronov vinogradnoĭ ulitki na atsetilkholin.