Morphologic characteristics of a transplantable tumor derived from a spontaneous malignant fibrous histiocytoma in the rat.
Malignant fibrous histiocytoma (MFH) developed spontaneously in subcutaneous tissue of the head of a 15-month-old male Fischer 344 rat. The tumor was serially transplanted into syngeneic rats up to the 45th generation and was designated MFH-MT. Light and electron microscopic examinations revealed that the original and serially transplanted tumors were composed of an admixture of fibroblast-like and histiocyte-like cells arranged in a storiform pattern. Neoplastic cells gave positive reactions for acid phosphatase, alkaline phosphatase, nonspecific esterase, alpha-1 antitrypsin and lysozyme. The tumors transplanted into the lungs and cutaneous tissue of the tail had a mixed histologic appearance of storiform, pleomorphic, myxoid and giant cell types. Moreover sclerosing hemangioma-like and osteosarcoma-like structures were also found. MFH-MT grew well in athymic nude mice showing neoplastic proliferation of pleomorphic cells strongly positive for alpha-1 antitrypsin. Development of MFH-MT was significantly retarded by the two antitumor drugs tested. The retarded tumors consisted predominantly of fibroblast-like cells and abundant collagenic fibers, whereas histiocytic cells decreased in number.
Yamate
J
J
Tajima
M
M
Shibuya
K
K
Ihara
M
M
Kudow
S
S
D000818:Animals; D005260:Female; D006257:Head; D018219:Histiocytoma, Benign Fibrous / Q000648:ultrastructure / Q000662:veterinary*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008853:Microscopy; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D012376:Rodent Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000648:ultrastructure / Q000662:veterinary*