A comparison of thermal responses of human and rodent cells.
A comparison of heat responses of cells from human and rodent tumors indicates the following: (1) human cells appear to be appreciably more heat-resistant than are rodent cells in the range 41-45 degrees C; (2) while rodent cells show a marked increase in sensitivity as the temperature is increased from 42 and 43 degrees C, this change occurs at approximately 44 degrees C or higher for the human lines examined; (3) rodent cells are unable to acquire thermotolerance during exposure to 43 degrees C; the human cells do so readily; (4) decay of tolerance tends to be complete in 72 h in rodent cells; in human cells it may take twice that time. These results may have important implications for the clinical use of hyperthermia.
Hahn
G M
GM
Department of Radiation Oncology, Stanford University, CA 94305-5468.
Ning
S C
SC
Elizaga
M
M
Kapp
D S
DS
Anderson
R L
RL
D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000503:physiopathology / Q000628:therapy*