Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.
Several isoforms of the platelet-derived growth factor (PDGF) have been identified and purified to date. The functional effects of the PDGF isoforms differ, due to their different interactions with at least two distinct cell surface receptors. Thus, PDGF constitutes an example of an expanding growth factor family, characterized by possibilities for fine-tuned regulation of action. In this manuscript, we describe the structural features of the PDGF isoforms as well as their receptors.
Claesson-Welsh
L
L
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
Heldin
C H
CH
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D015394:Molecular Structure; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor; D015398:Signal Transduction
D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017479:Receptors, Platelet-Derived Growth Factor