The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.
The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.
Spurr
N K
NK
Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.
Gough
A C
AC
Stevenson
K
K
Wolf
C R
CR
D000818:Animals; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D006899:Mixed Function Oxygenases / Q000235:genetics*; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A