1,2,3-triazolo[4,5-f]quinolines. II. Preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract (1).
Some 6-ethyl-1(2)(3)-R-1(2)(3)H-triazolo[4,5-f]quinolin-9-one-8-carboxy lic acids were prepared as novel analogues of oxolinic acid in order to evaluate the effect on antibacterial activity of the isosteric replacement of the dioxolic moiety with the triazole ring substituted in position 1 or 2. In vitro tests showed a good and selective activity against Escherichia coli (MIC 12.5 micrograms/ml) of compound (XVI).
Nuvole
A
A
Istituto di Chimica Farmaceutica, Università di Sassari, Italy.
Sanna
P
P
Paglietti
G
G
Juliano
C
C
Zanetti
S
S
Cappuccinelli
P
P
D000892:Anti-Infective Agents, Urinary / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D003470:Culture Media; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014230:Triazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
D000892:Anti-Infective Agents, Urinary; D003470:Culture Media; D015363:Quinolones; D014230:Triazoles