title: Repeated amphetamine: reduced dopamine neuronal responsiveness to apomorphine but not quinpirole.
abstract: Extracellular recordings from single nigrostriatal dopamine (DA) neurons in rats revealed significantly reduced neuronal sensitivity to the inhibitory effects of i.v. apomorphine following repeated amphetamine (4 mg/kg per day i.p., 14 days). This effect was reversed by acute SCH 23390. Quinpirole sensitivity was reduced in amphetamine-treated rats only following acute SKF 38393 pretreatment. These results suggest that, in amphetamine-treated animals, D-1 receptor activation is important for the expression of reduced nigrostriatal DA neuron sensitivity to apomorphine.
authors.affiliation: Laboratory of Neurophysiology, Center for Cell Biology, Sinai Research Institute, Detroit, MI 48235.
authors.forename: D K
authors.initials: DK
authors.lastname: Pitts
authors.forename: A S
authors.initials: AS
authors.lastname: Freeman
authors.forename: M D
authors.initials: MD
authors.lastname: Kelland
authors.forename: L A
authors.initials: LA
authors.lastname: Chiodo
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology*; D004594:Electrophysiology; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D015259:Dopamine Agents; D004873:Ergolines; D019257:Quinpirole; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine