[Processes of pathologic coagulation and fibrinolysis in epidemic hemorrhagic fever with renal lesion].
The processes of coagulation, anticoagulation and fibrinolysis as well as renal function were studied in 114 cases with epidemic hemorrhagic fever (EHF). The results showed that there were pathological coagulation and fibrinolysis and abnormal renal function in EHF. Comparing with normal controls, there was statistical significance (P less than 0.05) with the exception of fibrinogen. The degree of abnormality corresponded with the severity of the disease. With the observation of serial curves of these processes and renal function, we found out that there was correlation between them. Correlation analysis suggested that pathological coagulation and fibrinolysis could cause renal lesion or exacerbate it (P less than 0.05). The lesion affects mainly the glomerular filtration; whether it affects the tubular function or not is uncertain.
Gong
Z J
ZJ
Wu
Z O
ZO
Guan
M Y
MY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen; D010958:Plasminogen