[In vitro susceptibility testing of nontuberculous mycobacteria to streptomycin, kanamycin and enviomycin].
In vitro susceptibility testing to streptomycin, kanamycin and enviomycin was carried out in nontuberculous mycobacteria and the results were compared with those of M. tuberculosis strains. Among nontuberculous mycobacteria tested, only M. xenopi strains exhibited similar minimal inhibitory concentration (MIC) values to streptomycin with M. tuberculosis strains. On the other hand, M. xenopi, M. malmoense and M. marinum strains showed the same MIC values to kanamycin with the MIC values for M. tuberculosis strains. The MICs of enviomycin for M. kansasii, M. malmoense, M. szulgai, M. xenopi and M. marinum strains were similar to those for M. tuberculosis strains. Out of 64 strains of M. avium complex, the MIC value similar to that for M. tuberculosis strains was shown in 16% of strains to streptomycin, in 42% of strains to kanamycin, and in 50% of strains to enviomycin.
Tsukamura
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D004776:Enviomycin / Q000494:pharmacology*; D007612:Kanamycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology*; D014756:Viomycin / Q000494:pharmacology*
D007612:Kanamycin; D004776:Enviomycin; D013307:Streptomycin; D014756:Viomycin