Calcium reverses lidocaine-induced conduction block in rat fimbria in vitro.
1. We have tested the effect of changed concentrations of Ca2+ upon lidocaine-induced conduction block in rat fimbria. 2. With bath [Ca2+] of 0.25 mM, 0.5 mM lidocaine reduced the amplitude of the compound action potential to 20.2% +/- 2.25% of baseline (n = 5). 3. On changing the bath [Ca2+] to 4.4 mM, with no change in lidocaine concentration, the compound action potential increased by 33.5 +/- 6.5%. 4. In the absence of lidocaine, changing bath [Ca2+] had opposite effects. These results replicate findings by others in peripheral nerve.
Newmark
J
J
Department of Neurology, School of Medicine, University of Louisville, KY 40292.
Reid
K H
KH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D008012:Lidocaine; D002118:Calcium