Repair kinetics in mouse lung: a fast component at 1.1 Gy per fraction.
Four experiments to measure the half-time of repair of radiation damage in mouse lung are described. Three of these experiments used two or four doses per fraction of 3.6-9 Gy. Half-times of approximately 0.6 h were found. The fourth experiment investigated repair between the two doses in pairs of small doses given daily (26F x 1.1 Gy in 13 days). Evidence was obtained of more rapid repair between these small fractions, with a half-time of 0.30 h. Using the best methods of analysis appropriate to each experiment, the 95 per cent confidence limits for the T1/2 values at 1.1 Gy per fraction did not overlap with those for the large doses per fraction.
Fowler
J F
JF
Gray Laboratory of Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Whitsed
C A
CA
Joiner
M C
MC
D000818:Animals; D007700:Kinetics; D008168:Lung / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*