Effect of lithium chloride on spermatogenesis, testicular delta 5- 3 beta- and 17 beta-hydroxysteroid dehydrogenase activities in toad (Bufo melanostictus).
The purpose of the present study was to show the effects of lithium on testicular activities in the toad. Adult male toads were injected with lithium chloride (200 micrograms/toad) of alternate days for 21 days. At the moment of sacrifice on 22nd day, lithium treated animal showed decreases in testicular weight and Leydig cell nuclear area along with inhibition of spermatogenesis and testicular delta 5-3 beta as well as 17 beta-hydroxysteroid dehydrogenase activities. The results of our present experiment suggest that lithium administration might be associated with significant adverse effects on testicular activity in toad.
Ghosh
P K
PK
Department of Physiology, University of Calcutta, India.
Sarkar
M
M
Ghosh
P
P
Ghosh
A K
AK
Ghosh
D
D
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000279:Administration, Cutaneous; D000818:Animals; D001001:Anura; D002712:Chlorides / Q000494:pharmacology*; D004334:Drug Administration Schedule; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D009929:Organ Size; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
D002712:Chlorides; D008094:Lithium; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; D018021:Lithium Chloride