title: [The function of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing syndrome].
abstract: Altogether 28 patients with adrenocortical tumors (corticosteromas and corticoandrosteromas) were examined using a radioimmunoassay to determine the concentration of corticotropin, cortisol, blood cyclic nucleotides, the circadian rhythm and time course of corticotropin and cortisol levels against a background of insulin hypoglycemia. In patients with Itsenko-Cushing's syndrome the basel level of cortisol was notably raised, that of corticotropin was sharply decreased. The circadian rhythm of the levels of corticotropin and cortisol was disturbed, a response of the hypophyseal-adrenal system to a stressor was suppressed. The concentration of blood cyclic nucleotides was increased, and these changes were dependent on the nature of adrenal pathology.
authors.forename: E V
authors.initials: EV
authors.lastname: Luchitskiĭ
authors.forename: G V
authors.initials: GV
authors.lastname: Valueva
authors.forename: V V
authors.initials: VV
authors.lastname: Markov
authors.forename: V N
authors.initials: VN
authors.lastname: Slavnov
authors.forename: S I
authors.initials: SI
authors.lastname: Rybakov
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000503:physiopathology; D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D003480:Cushing Syndrome / Q000097:blood / Q000503:physiopathology*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology*
chemical_list: D007328:Insulin; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D006152:Cyclic GMP; D006854:Hydrocortisone
vernacular_title: Funktsional'noe sostoianie gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy pri sindrome Itsenko-Kushinga.