Increased methylation of chloroform extractable products and CTP: cholinephosphate cytidylyltransferase in brain membrane preparations from triethyltin-intoxicated rats.
Rats were chronically intoxicated with triethyltin in the drinking water (0.002%) for a period of 15 days. Starting with day 5 of the intoxication period a decrease in the body weight was observed and, in parallel, the development of a cerebral oedema could be followed by measuring white matter density. At the same time, an increase of phosphatidylethanolamine-N-methyltransferase and cholinephosphate cytidylyltransferase activities was noted. This increase might be a compensatory mechanism for counteracting the membrane damages induced by triethyltin.
Mages
F
F
Unité INSERM 205, Laboratory of Chemical Biology, INSA, Villeurbanne, France.
Macovschi
O
O
Prigent
A F
AF
Fonlupt
P
P
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000201:enzymology*; D001929:Brain Edema / Q000503:physiopathology; D002725:Chloroform; D019916:Choline-Phosphate Cytidylyltransferase; D003570:Cytidine Triphosphate / Q000378:metabolism*; D003597:Cytosine Nucleotides / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000378:metabolism; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*
D003597:Cytosine Nucleotides; D009419:Nerve Tissue Proteins; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D003570:Cytidine Triphosphate; D002725:Chloroform; D004247:DNA; D008780:Methyltransferases; D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase