title: [In vitro activity of 5 new quinolones against Gardnerella vaginalis].
abstract: The minimal inhibitory concentrations (MICs) of five new quinolones were determined by agar dilution, for 50 clinical isolates of Gardnerella vaginalis. They are compared with those of metronidazole, ampicillin, erythromycin and tetracycline which are widely used for the treatment of lower genital tract infections in women. The MICs of rosoxacin and pefloxacin are high, but those of ofloxacin (MIC 50, 2 mg/l), fleroxacin (MIC 50, 2 mg/l) and ciprofloxacin (MIC 50, 1 mg/l) are lower. They can explain the effectiveness observed with this latter antibiotic in vivo, and allow their clinical experiment.
authors.affiliation: Faculté de Médecine Purpan, Centre Hospitalier Régional, Toulouse.
authors.forename: J C
authors.initials: JC
authors.lastname: Lefevre
authors.forename: E
authors.initials: E
authors.lastname: Gaubert
authors.forename: M B
authors.initials: MB
authors.lastname: Lareng
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006194:Gardnerella vaginalis / Q000145:classification / Q000187:drug effects*; D006190:Haemophilus / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013754:Tetracyclines / Q000494:pharmacology
chemical_list: D015363:Quinolones; D013754:Tetracyclines; D008795:Metronidazole; D004917:Erythromycin; D000667:Ampicillin
vernacular_title: Activité in vitro de cinq nouvelles quinolones sur Gardnerella vaginalis.