Beta-adrenergic enhancement of angiotensin II-stimulated aldosterone secretion.
Beta-adrenergic agonists have been shown to stimulate aldosterone secretion. Angiotensin II (AII) is one of the important stimuli of aldosterone secretion; conceivably beta-adrenergic influences affect the stimulatory potential of AII. Using cultured rat adrenal capsules, we found that 10(-7) M epinephrine and 10(-7) M isoproterenol enhanced 10(-7) M AII-stimulated aldosterone production. Propranolol (10(-7) M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII. In conclusion, beta-adrenergic agonists promote stimulation of aldosterone secretion by AII.
Pratt
J H
JH
Department of Medicine, Indiana University School of Medicine, Indianapolis.
McAteer
J A
JA
D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D000804:Angiotensin II; D000450:Aldosterone; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine