Viral infection correlated with superoxide anion radicals production and natural and synthetic copper complexes.
Studies conducted on asymmetric triazine derivatives synthetized at the Chemical and Pharmaceutical Research Institute showed that products S1, S16, S17, S19, S20 and S22 have a remarkable O2- radical scavenger activity. Among these derivatives, the product S1 is the most efficient as an antiviral agent.
Tomas
E
E
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Popescu
A
A
Titire
A
A
Cajal
N
N
Cristescu
C
C
Tomas
S
S
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003300:Copper / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D066298:In Vitro Techniques; D051379:Mice; D013481:Superoxides / Q000378:metabolism*; D014227:Triazines / Q000627:therapeutic use*; D014777:Virus Diseases / Q000188:drug therapy / Q000378:metabolism*
D000998:Antiviral Agents; D005609:Free Radicals; D014227:Triazines; D013481:Superoxides; D003300:Copper