Postnatal effects of maternal nicotine exposure on the striatal dopaminergic system in rats.
The biochemical effects of continuous prenatal exposure to nicotine (1.5 mg kg-1 day-1) have been examined in 14 day old male and female rat pups. The ability of striatal tissue slices from the nicotine-exposed pups to synthesize [3H]dopamine from [3H]tyrosine was enhanced. However, the ability of (+)-amphetamine to stimulate formation and release of [3H]dopamine from [3H]tyrosine was not affected. Furthermore, prenatal exposure to nicotine increased the rate of striatal dopamine turnover in the male, but not the female nicotine-exposed pups.
Fung
Y K
YK
University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln 68583-0740.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D014443:Tyrosine / Q000378:metabolism; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D014443:Tyrosine; D019805:alpha-Methyltyrosine; D009538:Nicotine; D003913:Dextroamphetamine; D004298:Dopamine