The role of endogenous and exogenous prostacyclin in the gastric mucosa under physiological and pathological circumstances.
The intracellular effect of exogenously administered prostacyclin in the gastric mucosa seems to be a polyphasic effect, namely: 1. Effect on the cyclic nucleotide (cAMP, cGMP), turnover; 2. Effect on the calmodulin-content; 3. DNA and RNA changes; 4. Influence on protein synthesis; 5. New cell formation. While the endogenous prostacyclin exerts a natural protection against damaging noxae.
Bálint
G A
GA
First Department of Medicine, University Medical School, Szeged, Hungary.
Varró
V
V
D000818:Animals; D002118:Calcium / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D011464:Epoprostenol / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D012907:Smoking / Q000009:adverse effects; D013276:Stomach Ulcer / Q000517:prevention & control*
D002147:Calmodulin; D011464:Epoprostenol; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium