[Effect of linoleic acid in the diet on arterial pressure, ATPase activity and cyclic nucleotide level in the heart of rats with spontaneous hypertension].
A study was made of the effect of exogenous linoleic acid introduced with feed in the amount of 0.1 cal. % (group I), 9 cal. % (group II) and 16 cal. % (group III) on arterial pressure, Na, K- and Ca-ATPase activity, and on the content of cyclic nucleotides in normotensive Wistar Kyoto rats (NR) and in spontaneously hypertensive Okamoto Aoki rats (SHR). It is established that both deficiency (group I) and excess (group III) amount of linoleic acid in the diet brought about different material changes in the activity of ATPases. Nevertheless, arterial pressure rose in these animals' groups as compared to control (group II). At the same time the degree of arterial pressure rise in NR was higher than in SHR (in percent with respect to the control rats). The content of cAMP and cGMP was appreciably reduced in the animals of the 3 groups (in NR and SHR).
Vasil'eva
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Ziabkina
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D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D006152:Cyclic GMP
Vliianie linolevoĭ kisloty v ratsione na arterial'noe davlenie, aktivnost' ATFaz i soderzhanie tsiklicheskikh nukleotidov v serdtse krys so spontannoĭ gipertenzieĭ.