title: L-ascorbic acid produces hypoglycaemia and hyperinsulinaemia in anaesthetized rats.
abstract: L-Ascorbic acid (Vitamin C) produced a marked reduction in the blood glucose concentration following intravenous injection (20-100 mg kg-1) to anaesthetized rats. This hypoglycaemic effect was accompanied by an increase in plasma insulin concentration. D-ascorbic acid produced a similar hypoglycaemic effect.
authors.affiliation: Department of Pharmacology, College of Medicine, National Cheng Kung University, Taiwan, Republic of China.
authors.forename: J T
authors.initials: JT
authors.lastname: Cheng
authors.forename: S C
authors.initials: SC
authors.lastname: Hsieh-Chen
authors.forename: C L
authors.initials: CL
authors.lastname: Tsai
mesh_terms: D000758:Anesthesia; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D007328:Insulin; D001205:Ascorbic Acid