title: The use of animal experiments for assessing annual limits on intake and interpreting chest-monitoring data for workers exposed to industrial actinide-bearing dusts.
abstract: The metabolic behavior of 239Pu and 241Am present in three industrial dusts has been studied after their inhalation by the rat. A comparative experiment has also been carried out with a mixture of these actinides, inhaled as their nitrates. The aim of this work was to provide an experimental basis for assessing limits on intake and to establish whether the 239Pu content in the lungs could be interpolated from measurements of 241Am. The results (1) demonstrate the wide differences in the lung retention kinetics of the actinides and in the absolute and relative amounts which translocate to the blood that can occur for industrially produced materials; (2) show that the annual limits on intake (ALI) for the different materials vary between those postulated for class W and Y compounds by the International Commission on Radiological Protection; (3) indicate that, depending on the nature of the dust, acute intakes of 239Pu equivalent to the ALI can be estimated from 241Am chest-monitoring data at times from a few days up to about 3 y after exposure.
authors.affiliation: National Radiological Protection Board, Didcot, Oxon, United Kingdom.
authors.forename: G N
authors.initials: GN
authors.lastname: Stradling
authors.forename: J W
authors.initials: JW
authors.lastname: Stather
mesh_terms: D008671:Actinoid Series Elements / Q000493:pharmacokinetics*; D000336:Aerosols; D000395:Air Pollutants, Occupational; D000576:Americium / Q000493:pharmacokinetics; D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism*; D011005:Plutonium / Q000493:pharmacokinetics; D011834:Radiation Monitoring; D011835:Radiation Protection; D051381:Rats; D013045:Species Specificity
chemical_list: D008671:Actinoid Series Elements; D000336:Aerosols; D000395:Air Pollutants, Occupational; C034018:americium oxide; C026885:plutonium dioxide; C041805:americium nitrate; D011005:Plutonium; D000576:Americium