Transport of alpha-aminoisobutyric acid into rat parotid after X-irradiation.
Rat parotid gland exposed to 20 Gy X-irradiation exhibits functional alteration 3 days after exposure. The flow rate of saliva and the uptake of alpha-aminoisobutyric acid by the gland was reduced to 50 per cent of values for the control nonirradiated glands. When the same gland was studied in an in vitro system it functioned normally. K+ release and alpha-aminoisobutyric acid uptake by the irradiated dispersed acinar cells was comparable to the control. Transport alteration from the circulatory system into the parotid gland may cause the initial radiation-induced damage.
Bodner
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Section of Oral and Maxillofacial Surgery, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics*; D000818:Animals; D001693:Biological Transport, Active / Q000528:radiation effects; D066298:In Vitro Techniques; D008297:Male; D010306:Parotid Gland / Q000378:metabolism / Q000528:radiation effects*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism / Q000528:radiation effects; D012636:Secretory Rate / Q000528:radiation effects
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid; D011188:Potassium