Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population.
In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.
Vidaud
M
M
INSERM U. 91, Hôpital H. Mondor, Créteil, France.
Kitzis
A
A
Ferec
C
C
Bozon
D
D
Dumur
V
V
Giraud
G
G
David
F
F
Pascal
O
O
Auvinet
M
M
Morel
Y
Y
D003550:Cystic Fibrosis / Q000235:genetics*; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers