Depressor effects of muscarinic and non-muscarinic mediation induced by lateral hypothalamic stimulation in the cat.
Transient sympathetically-mediated depressor effects were induced by stimulation of a small locus in the lateral hypothalamic peri-fornical region, medial to the fields of Forel. The ganglionic blocking agent, atropine methyl nitrate (ATMN), was used to show that muscarinic as well as non-muscarinic sympathetic ganglion receptor neurotransmission was involved. Evidence is presented that stimulation of this LH site co-activates a number of mechanisms and that depending on which of these are activated, the ganglionic blocking agent ATMN may either block, reverse or potentiate the depressor effect.
Blum
B
B
Sackler School of Medicine, Dept. of Physiology and Pharmacology, Tel Aviv University, Israel.
Israeli
J
J
Hart
O
O
Farchi
M
M
D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D001286:Atropine Derivatives; D011976:Receptors, Muscarinic; C006649:methylatropine