[HIV infection in stage IV C-2 (CDC). Increase in the p24 antigen value before critical decrease in CD4+ lymphocytes].
The Center for Disease Control proposed a classification system of HIV-infection including a symptomatic stage IV C-2 with secondary infections like thrush, oral hairy leukoplakia and herpes zoster. Because the prognostic value of these symptoms for the development of AIDS has been proven and the CDC-classification does not include any immunological parameters we analyzed the numbers of CD4+-lymphocytes and the frequency of HIV-antigen in 65 HIV-infected individuals. When entering stage IV C-2, the incidence of HIV-antigenemia was as high as in full blown AIDS (53% and 60%, respectively). However, we observed no decrease of CD4+-lymphocytes as compared to earlier CDC-stages.--We conclude that in stage IV C-2 the increase of viral protein production proceeds independently from CD4+-status.
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D015704:CD4 Antigens / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002487:Centers for Disease Control and Prevention, U.S.; D015683:Gene Products, gag / Q000032:analysis*; D016655:HIV Core Protein p24; D015658:HIV Infections / Q000145:classification* / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D014481:United States; D014758:Viral Core Proteins / Q000032:analysis*
D015704:CD4 Antigens; D015683:Gene Products, gag; D016655:HIV Core Protein p24; D014758:Viral Core Proteins
HIV-Infektion im Stadium IV C-2 (CDC). Zunahme der p24-Antigen-Frequenz vor der kritischen Erniedrigung der CD4+-Lymphozyten.