title: Monoclonal antibodies to type D retrovirus (SRV-2).
abstract: Monoclonal antibodies (MoAbs) to the major gag core protein p27 and a viral protein p44 of type D retrovirus (SRV-2) were produced and used in the detection of SRV-2 antigens in infected Raji cells and in tissues from macaques with simian acquired immunodeficiency syndrome (SAIDS) and retroperitoneal fibromatosis (RF). Anti-p44 MoAb showed inhibition of syncytium formation by both SRV-1- and SRV-2-infected Raji cells.
authors.affiliation: Department of Pathology, St. Louis University School of Medicine, MO.
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: J M
authors.initials: JM
authors.lastname: Sligh
authors.forename: M
authors.initials: M
authors.lastname: Yarnall
authors.forename: K E
authors.initials: KE
authors.lastname: Follis
authors.forename: S T
authors.initials: ST
authors.lastname: Roodman
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis* / Q000276:immunology; D015153:Blotting, Western; D002460:Cell Line; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D015683:Gene Products, gag; D006825:Hybridomas; D007150:Immunohistochemistry; D009500:Neutralization Tests; D012191:Retroviridae Proteins / Q000276:immunology; D015301:Retroviruses, Simian / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D015683:Gene Products, gag; D012191:Retroviridae Proteins