title: Cefazaflur: kinetics of hydrolysis in aqueous solution, acid dissociation constant and alkaline decomposition to fluorescent products.
abstract: The values of the pseudo-first order hydrolysis rate constants in the pH range 1 to 10, and the pKa, were determined for cefazaflur in aqueous solution at 37 degrees C and ionic strength 0.2 M. A fluorimetric assay, based on alkaline hydrolysis at 100 degrees C, was also developed for this compound. The results are consistent with previously reported related properties of other monoprotic cephalosporins.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Trinity College, Dublin, Ireland.
authors.forename: V P
authors.initials: VP
authors.lastname: Irwin
authors.forename: R F
authors.initials: RF
authors.lastname: Timoney
mesh_terms: D002511:Cephalosporins / Q000493:pharmacokinetics*; D005453:Fluorescence; D006868:Hydrolysis; D007700:Kinetics; D012996:Solutions
chemical_list: D002511:Cephalosporins; D012996:Solutions; C010529:cefazaflur