Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone.
Previous research has demonstrated that excitatory amino acids acting at N-methyl-D-aspartate (NMDA) receptors stimulate the release of luteinizing hormone (LH). Castration also elevates LH, an effect that may also involve NMDA receptors since the specific NMDA antagonist, DL-2-amino-5-phosphonopentanoic acid (AP5), antagonizes this action. Since PCP antagonizes a variety of actions of NMDA agonists, we hypothesized that it would diminish the ability of glutamate, homocysteic acid and castration to elevate LH. Our data support this hypothesis.
Boggan
W O
WO
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425-0742.
Ondo
J G
JG
D000818:Animals; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D007276:Injections, Intraventricular; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009919:Orchiectomy; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D006710:Homocysteine; C007956:homocysteic acid; D018698:Glutamic Acid; D007986:Luteinizing Hormone; D010622:Phencyclidine