Effect of rate of injection on the neuromuscular block produced by vecuronium.
A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produced peak plasma levels of drug considerably greater than those following slow infusion. Time to maximum block was more rapid following bolus (368 +/- 84 [SD] sec) than by infusion (615 +/- 88 sec), but the maximum block produced, either demonstrated by the reduction in amplitude of T1 from control or the T1:T4 ratio on the integrated electromyogram (Datex IEMG), was similar in each group irrespective of rate of injection, T1 and T4 referring to the first and last twitch in a train of four series.
Feldman
S A
SA
Magill Department of Anaesthetics, Westminster Hospital, University of London, England.
Soni
N
N
Kraayenbrink
M A
MA
D000328:Adult; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D009469:Neuromuscular Junction / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage* / Q000097:blood
D014673:Vecuronium Bromide