C-type virus particles in placentas of rhesus monkeys after maternal treatment with recombinant leukocyte A interferon.
Interferon inhibits the normal replication of C-type virus particles grown in vitro. The ability of interferon to produce a similar effect in vivo was tested in rhesus monkey placentas which are known to contain C-type virus particles. Samples of placenta from 6 monkeys treated with recombinant leukocyte A interferon (25 x 10(6) units/kg) for 7 to 21 days and from 6 control monkeys were examined in the electron microscope. Budding and immature C-type virus particles were present in every placenta examined from both interferon-treated and control monkeys. Mature particles were found in placentas from 3 of 6 monkeys in both treated and control groups. Possible explanations for the absence of detectable effects of interferon in C-type virus particle formation in these placentas are unresponsiveness of the trophoblast to interferon or inadequate exposure time to interferon of placental sites from which C-type particles are produced.
Feldman
D
D
Hoffman-La Roche Inc., Nutley, NJ.
Valentine
T
T
Niemann
W H
WH
Hoar
R M
RM
Cukierski
M
M
Hendrickx
A
A
D000818:Animals; D005260:Female; D007370:Interferon Type I / Q000032:analysis / Q000494:pharmacology*; D007962:Leukocytes / Q000032:analysis*; D008253:Macaca mulatta; D008854:Microscopy, Electron; D010920:Placenta / Q000187:drug effects / Q000382:microbiology* / Q000648:ultrastructure; D011247:Pregnancy; D011994:Recombinant Proteins; D012190:Retroviridae / Q000302:isolation & purification / Q000648:ultrastructure*; D014412:Tumor Virus Infections / Q000473:pathology
D007370:Interferon Type I; D011994:Recombinant Proteins