Evidence for age-related change in plasma 19-hydroxyandrostenedione.
The steroid, 19-hydroxyandrost-4-ene-3, 17-dione (19-hydroxyandrostene-dione, 19-OH-A-dione) has been known to enhance the mineralocorticoid action of aldosterone. To investigate the age-related change in the plasma 19-OH-A-dione concentration, plasma 19-OH-A-dione, androst-4-ene-3, 17-dione (A-dione), aldosterone and cortisol of 38 non-hypertensive healthy subjects (18 young men and 20 aged men) measured by specific radioimmunoassays. The basal plasma 19-OH-A-dione and A-dione concentration in aged men was significantly lower than in young men (P less than 0.01). Moreover, there was found to be a positive correlation between plasma 19-OH-A-dione and A-dione (P less than 0.01). On the other hand, plasma aldosterone and cortisol in aged men showed a tendency to decrease, but no statistical significance compared to young men was observed. This study demonstrated that there was an apparent age-related decrease not only in plasma A-dione, but also in plasma 19-OH-A-dione, an amplifier or aldosterone action.
Higuchi
K
K
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ogo
A
A
Maki
T
T
Haji
M
M
Takayanagi
R
R
Ohashi
M
M
Nawata
H
H
Kato
K
K
Ibayashi
H
H
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000450:Aldosterone / Q000097:blood; D000735:Androstenedione / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male
D000735:Androstenedione; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; C011482:19-hydroxy-4-androstene-3,17-dione; D006854:Hydrocortisone