[Anticonvulsive properties of peptide ACTH4-7 pro-gly-pro detected in amygdaloid kindling and audiogenic epilepsy in rats].
Effects of the ACTH4-7 pro-gly-pro, calcium valproate ("Germed", DDR) and nembutal on kindling preparation and audiogenic epilepsy were investigated. Development of after-discharges in response to repeated amygdaloid electrical stimulation was assessed in normal rats and in rats susceptible to audiogenic epilepsy (KM line of rats). ACTH4-7 pro-gly-pro had an anticonvulsant profile. ACTH4-7 pro-gly-pro decreased seizure threshold in the audiogenic epilepsy test, but did not prevent the motor convulsions.
Chepurnov
S A
SA
Chepurnova
N E
NE
Artiukhova
M V
MV
Kuznetsova
E Iu
EIu
Nezavibat'ko
V N
VN
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000627:therapeutic use / Q000031:analogs & derivatives; D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation / Q000379:methods; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology / Q000627:therapeutic use; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use
D000927:Anticonvulsants; D003692:Delayed-Action Preparations; D010446:Peptide Fragments; D014635:Valproic Acid; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D010424:Pentobarbital
Protivosudorozhnie svoĭstva peptida AKTG4-7 pro-gli-pro, vyiavliaemye pri amigdaliarnoĭ raskachke i audiogennoĭ épilepsii u krys.