[Intrapenile neurotransmission. Physiologic data and practical consequences].
This paper reviews the intrapenile control of erection and the principal pathophysiological and therapeutic implications (especially intracavernous injections) of these physiological data. The regulation of flaccidity is fairly well known. This principally results from a continuous adrenergic discharge responsible, via activation of the alpha receptors, for tonic contraction of the smooth muscle fibres (SMF) of the corpora cavernosa (CC), preventing blood from entering the spaces of the CC. The complementary role of serotonin, histamine, prostaglandins (PG) F1 and F2 alpha and neuropeptide Y is still unclear. The regulation of erection is less well understood. The principal phenomenon is probably inhibition of the anti-erectile alpha adrenergic tone, allowing relaxation of the SMF and congestion of the areolae of the CC, influx of arterial blood and occlusion of the venous exits. However, an additional relaxing nervous stimulation may also be required. The modulation of anti-erectile adrenergic activity could be the result of Vasoactive-Intestinal-Polypeptide which, however, is unable to induce complete erection on its own, and/or PGE1. Acetylcholine, whose role is still unclear, stimulation of beta adrenergic receptors and presynaptic alpha-2 receptors, histamine, a relaxant factor of endothelial origin and possibly other neurotransmitters as yet unidentified, may also be involved.
Buvat
J
J
Association pour l'Etude de la Pathologie de l'Appareil Reproducteur et de la Psychosomatique, Lille.
D000527:Alprostadil / Q000502:physiology / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000294:innervation* / Q000503:physiopathology; D013566:Sympathomimetics / Q000627:therapeutic use; D009435:Synaptic Transmission; D014660:Vasoactive Intestinal Peptide / Q000502:physiology / Q000627:therapeutic use
D013566:Sympathomimetics; D014660:Vasoactive Intestinal Peptide; D000527:Alprostadil
La neurotransmission intrapénienne. Données physiologiques et conséquences pratiques.