Decreased reactivity to the anticonflict effect of diazepam in perinatally undernourished rats.
Offspring of rats were submitted to a protein deprivation dietary treatment from the third week of gestation until 50 days of age, and later nutritionally rehabilitated for at least 90 days. In the punished lever-pressing conflict test, undernourished animals exhibited a decreased reactivity to the anticonflict effect of a 3 mg/kg dose of diazepam as compared to control animals. This decreased reactivity to diazepam in a shock-induced conflict test indicates that functional alterations in the GABAergic transmission might contribute to the state of hypersensitivity to stressful or aversive situations present in undernourished animals.
Brioni
J D
JD
Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Cordoba
N
N
Orsingher
O A
OA
D000818:Animals; D000831:Animals, Newborn; D001143:Arousal / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011502:Protein-Energy Malnutrition / Q000523:psychology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D011963:Receptors, GABA-A; D003975:Diazepam