Beneficial effect of brief pre-transfusion incubation of platelets at 37 degrees C.
The effects of brief warming of stored platelet concentrates were assessed in 15 children undergoing transfusion for stable thrombocytopenia due to chemotherapy (n = 13) or aplastic anaemia. Half of a pool of platelet concentrates stored at 22 degrees C was incubated at 37 degrees C for 1 hour and the other half at room temperature. Each patient received one bag of warmed and one of unwarmed cells transfused in random order 2 h apart. Platelet warming improved transfusion efficacy, as assessed on the basis of corrected platelet count increments (CCIs) and platelet morphology. Compared with unwarmed bags, warmed bags had a higher morphology score (p = 0.0001) and a higher CCI (adjusted for the transfusion order) at 1 h (n = 11; p = 0.014) and at 2 h (n = 15, p = 0.006) post transfusion. Thus, with platelets stored at room temperature bags warmed before transfusion to 37 degrees C for 1 h provide a larger number of circulating platelets after transfusion than do unwarmed bags.
Hutchinson
R E
RE
Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee.
Kunkel
K D
KD
Schell
M J
MJ
Jackson
C W
CW
Nelson
E J
EJ
Wang
W C
WC
Fischl
S J
SJ
Taylor
L B
LB
Garcez
R B
RB
Pui
C H
CH
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000033:anatomy & histology; D001803:Blood Transfusion / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D006358:Hot Temperature; D006801:Humans; D007185:Incubators; D007223:Infant; D010976:Platelet Count; D017713:Platelet Transfusion; D011897:Random Allocation; D012494:Sampling Studies; D013048:Specimen Handling / Q000379:methods; D013696:Temperature; D013921:Thrombocytopenia / Q000628:therapy; D013997:Time Factors