title: Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells.
abstract: Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus-infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.
authors.affiliation: Biologisches Institut, Universität Stuttgart, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Horsch
authors.forename: C
authors.initials: C
authors.lastname: Martins de Sa
authors.forename: B
authors.initials: B
authors.lastname: Dineva
authors.forename: E
authors.initials: E
authors.lastname: Spindler
authors.forename: H P
authors.initials: HP
authors.lastname: Schmid
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000502:physiology*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005914:Globins / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000378:metabolism; D011132:Polyribosomes / Q000032:analysis; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D011817:Rabbits; D012261:Ribonucleoproteins / Q000378:metabolism*
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral; D012261:Ribonucleoproteins; D011061:Poly A; D005914:Globins