Effect of hydrocortisone on synaptic transmission in surviving rat olfactory cortex slices.
A study has been made of the effect of bath-applied hydrocortisone (10(-4) M) on excitatory transmission of the lateral olfactory tract (LOT), a superficial pyramidal cell synapse of the rat olfactory cortex slice. Populations EPSP and IPSP were depressed for 6-12 min and were then increased (60 min) by hydrocortisone. Recovery of evoked potentials was prolonged (40-60 min) when slices were washed with normal incubation medium. Habituation of synaptic potential during LOT repeated stimulation deteriorated as a result of hydrocortisone application in perfusion solution. The data obtained were considered to represent functions of adaption of the nervous system to a stressor.
Mokrushin
A A
AA
Laboratory of Experimental Endocrinology, I.P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad.
Bagaeva
T R
TR
Gerasimova
I A
IA
Emel'yanov
N A
NA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects
D006854:Hydrocortisone