[Mixed benzodiazepine poisoning and reversal with flumazenil (Ro 15-1788)].
A case of 17 year old female with acute benzodiazepines (800 mg of bentazepan and 400 mg de chlordiazepoxide) and tricyclic antidepressants (500 mg of imipramine) self poisoning is reported. Initial examination showed comatous patient (Glasgow coma scale 7, sedation scale 4) and a critical respiratory failure with a suspicious of pulmonary aspiration of gastric contents. Supportive measures were started and flumazenil administered intravenous (0.1 mg/min) until a total dose of 1.2 mg; 15 minutes later neurological state was absolutely normal. We conclude that flumazenil is a selective and useful benzodiazepine antagonist in the treatment of acute benzodiazepine poisoning.
Rivas López
F A
FA
López Soriano
F
F
Mendoza Cerezo
A
A
Jiménez Ferré
J
J
Azurmendi Rodríguez
J I
JI
de la Rubia Nieto
M A
MA
D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000506:poisoning*; D001381:Azepines / Q000506:poisoning*; D003009:Clorazepate Dipotassium / Q000506:poisoning*; D005260:Female; D005442:Flumazenil / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000506:poisoning*; D011963:Receptors, GABA-A / Q000187:drug effects; D013406:Suicide, Attempted
D014151:Anti-Anxiety Agents; D001381:Azepines; D011963:Receptors, GABA-A; D005442:Flumazenil; D003009:Clorazepate Dipotassium; C006129:bentazepam; D007099:Imipramine
Intoxicación benzodiacepínica mixta y reversión por flumacenil (Ro 15-1788).