A mitochondrial frameshift suppressor maps in the tRNASer-var1 region of the mitochondrial genome of the yeast S. cerevisiae.
A polypeptide chain-terminating mutation (M5631) previously has been shown to be a +1T insertion in the yeast mitochondrial gene oxi1, coding for subunit II of the cytochrome c oxidase. A spontaneously arisen frameshift suppressor (mfs-1) that is mitochondrially inherited suppresses this mutation to a considerable extent. The suppressor mutation was mapped by genetic and molecular analyses in the mitochondrial tRNASer-var1 region of the mitochondrial genome of the yeast S. cerevisiae. Genetic analyses show that the suppressor mfs-1 does not suppress other known mitochondrial frameshift mutations, or missense and nonsense mutations.
Weiss-Brummer
B
B
Institut für Genetik und Mikrobiologie, Universität München, Federal Republic of Germany.
Sakai
H
H
Hüttenhofer
A
A
D000595:Amino Acid Sequence; D003433:Crosses, Genetic; D003576:Electron Transport Complex IV / Q000235:genetics; D005800:Genes, Fungal; D008928:Mitochondria; D008969:Molecular Sequence Data; D012331:RNA, Fungal / Q000235:genetics*; D012335:RNA, Ribosomal / Q000235:genetics; D012345:RNA, Transfer, Amino Acid-Specific / Q000235:genetics*; D012362:RNA, Transfer, Ser / Q000235:genetics*; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013489:Suppression, Genetic
D012331:RNA, Fungal; D012335:RNA, Ribosomal; D012345:RNA, Transfer, Amino Acid-Specific; D012362:RNA, Transfer, Ser; D003576:Electron Transport Complex IV