title: Parvovirus B19 infection associated with reticulocytopenia and chronic autoimmune hemolytic anemia.
abstract: A previously healthy 11-year-old white female presented with a Coomb's positive hemolytic anemia and reticulocytopenia. The patient was treated with prednisone (6.4 mg/kg/day) and had a stable hemoglobin with subsequent recovery of reticulocytes by 7 days. Bone marrow aspiration showed hypercellularity with arrest of red cell maturation. The patient's serum contained specific IgM and IgG antibodies to parvovirus B19. Our report confirms parvovirus B19 as a cause of reticulocytopenia at presentation in autoimmune hemolytic anemia. Immunosuppressive therapy with prednisone did not appear to significantly prolong the course of the B19 infection.
authors.affiliation: Department of Pediatric Subspecialities, Geisinger Medical Center, Danville, Pennsylvania.
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: N S
authors.initials: NS
authors.lastname: Shah
authors.forename: J S
authors.initials: JS
authors.lastname: Lobel
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000150:complications; D001772:Blood Cell Count; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010322:Parvoviridae Infections / Q000097:blood* / Q000150:complications; D011241:Prednisone / Q000494:pharmacology; D012156:Reticulocytes / Q000187:drug effects
chemical_list: D011241:Prednisone