title: Pancreatic vasoactive intestinal polypeptide-secreting tumor: report of a case.
abstract: A 58-year-old Taiwanese woman was admitted to Mackay Memorial Hospital for evaluation profuse watery diarrhea. She presented with watery diarrhea, hypokalemia, and hypochlorhydria, and had experienced these problems for 2 years prior to admission. A pancreatic tumor with liver metastasis was noted by the ultrasound, abdominal CT scanning, and angiography studies. Surgical exploration disclosed an ill-defined ovoid tumor in the body and tail of the pancreas measuring 8 x 3 x 3 cm. The immunohistochemistry study of the tumor for VIP-immunoreactivity (VIP: vasoactive intestinal polypeptide) was markedly positive, and also stained slightly positive for other peptides, including pancreatic polypeptide (PP), calcitonin, glucagon, and neuron-specific enolase (NSE). Postoperatively, the patient recovered immediately from her symptoms and there has been no evidence of recurrence during the past 8 months of follow-up.
authors.forename: H W
authors.initials: HW
authors.lastname: Sheu
authors.forename: S Y
authors.initials: SY
authors.lastname: Chou
authors.forename: K C
authors.initials: KC
authors.lastname: Yang
authors.forename: C R
authors.initials: CR
authors.lastname: Kao
authors.forename: T L
authors.initials: TL
authors.lastname: Yang
authors.forename: C C
authors.initials: CC
authors.lastname: Shih
mesh_terms: D007516:Adenoma, Islet Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D003969:Vipoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D014660:Vasoactive Intestinal Peptide