[The role of protein kinase C in tumor growth].
A review of recent papers dealing with the role of protein kinase C (PK C) in regulation of normal and tumour cell proliferation contains the data on the interaction of PK C with the tumour promoters and oncoproteins as well as the data which characterize changes of the PK C activity in tumour cells and during carcinogenesis. Probable mechanisms of the PK C influence on the functioning of the growth factors receptors are discussed. It is proposed that one of the PK C functions which is substantial for induction of the mitogenic signal is the polyamine synthesis stimulation. Participation of PK C in the tumour promotion may play a key role in multistep processes of the carcinogenesis.
Khodosova
I A
IA
Zakharova
N V
NV
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000502:physiology; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000503:physiopathology*; D011073:Polyamines / Q000096:biosynthesis; D011493:Protein Kinase C / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology
D002273:Carcinogens; D006133:Growth Substances; D009363:Neoplasm Proteins; D011073:Polyamines; D011956:Receptors, Cell Surface; D011493:Protein Kinase C
Rol' proteinkinazy C v opukholevom roste.