title: Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.
abstract: A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinetics of the combined treatment.
authors.affiliation: Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Kuzuya
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: M
authors.initials: M
authors.lastname: Nadai
authors.forename: R
authors.initials: R
authors.lastname: Apichartpichean
authors.forename: Y
authors.initials: Y
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D005260:Female; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015363:Quinolones / Q000009:adverse effects / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D006633:Histamine Antagonists; D015363:Quinolones; C048522:repirinast; D013806:Theophylline