Metastatic vipoma arising from colonic primary tumour.
We describe a case of a tumour of the sigmoid colon with hepatic metastases in a patient with previously documented ulcerative colitis. A diagnosis of metastatic vipoma was made on the basis of high plasma levels of vasoactive intestinal polypeptide (VIP). Profuse diarrhoea and profound metabolic upset were corrected by the use of a somatostatin analogue SMS 201-995, whilst conventional cytotoxic therapy produced a significant tumour response with return of the plasma VIP level to normal.
Bradley
C
C
Department of Medical Oncology, University of Glasgow, Scotland.
Haddock
G
G
Pickard
R G
RG
Rankin
E M
EM
D007516:Adenoma, Islet Cell / Q000556:secondary*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000097:blood / Q000473:pathology; D003125:Colostomy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000556:secondary / Q000628:therapy; D015282:Octreotide / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000097:blood / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D012811:Sigmoid Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D013311:Streptozocin / Q000008:administration & dosage; D014660:Vasoactive Intestinal Peptide / Q000097:blood; D003969:Vipoma / Q000097:blood / Q000473:pathology / Q000556:secondary* / Q000628:therapy
D014660:Vasoactive Intestinal Peptide; D013311:Streptozocin; D015282:Octreotide