title: Epidemic hemorrhagic fever with renal syndrome in Yugoslavia, 1986.
abstract: An epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia May-November 1986; all Republics and Provinces were involved. Serum samples were received from 260 of 276 persons with symptoms clinically compatible with a diagnosis of HFRS. Presumptive infection with a hantavirus was determined serologically for 161 of these. Many patients with serious clinical pictures, including severe renal insufficiency and shock, were hospitalized; 11 died. Indirect fluorescent antibody tests with antigens of 4 hantaviruses (Hantaan, Fojnica, Puumala, and the Vranica strain of Puumala virus) showed that greater than 1 serotype was circulating during this epidemic. Hantavirus antigens were detected in the lungs of 86 of 302 (28.5%) wild-caught small mammals.
authors.affiliation: Institute of Immunobiology and Virology Torlak, Belgrade, Yugoslavia.
authors.forename: A
authors.initials: A
authors.lastname: Gligić
authors.forename: M
authors.initials: M
authors.lastname: Obradović
authors.forename: R
authors.initials: R
authors.lastname: Stojanović
authors.forename: N
authors.initials: N
authors.lastname: Vujosević
authors.forename: A
authors.initials: A
authors.lastname: Ovcarić
authors.forename: M
authors.initials: M
authors.lastname: Frusic
authors.forename: C J
authors.initials: CJ
authors.lastname: Gibbs
authors.forename: C H
authors.initials: CH
authors.lastname: Calisher
authors.forename: D C
authors.initials: DC
authors.lastname: Gajdusek
mesh_terms: D004196:Disease Outbreaks; D006476:Orthohantavirus / Q000276:immunology / Q000302:isolation & purification; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology* / Q000401:mortality; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D013997:Time Factors; D015022:Yugoslavia
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M