The relationship of the resonant recognition model to effects of low-intensity light on cell growth.
The resonant recognition model (RRM) is a model of protein-protein and protein-DNA interaction based on a significant correlation between spectra of numerical presentation of the amino acid or nucleotide sequences and their biological activity. Having compared absorption characteristics of photosensitive proteins with their RRM spectral characteristics we obtained a linear correlation between the RRM frequency space and real frequency space, which determines a scaling factor between these two frequency spaces. On applying the RRM model to several groups of peptide growth factors, characteristic RRM frequencies were revealed and the corresponding real characteristic frequencies for these groups of growth factors were calculated using the scaling factor previously obtained. The real frequency characteristics of growth factors obtained in this way correspond with maxima in the action spectra of low-intensity light irradiation effects on cell proliferation.
Cosic
I
I
Laboratory for Multidisciplinary Research, Boris Kidric Institute-Vinca, Beograd, Yugoslavia.
Vojisavljevic
V
V
Pavlovic
M
M
D000818:Animals; D002455:Cell Division; D006133:Growth Substances / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008027:Light; D046911:Macromolecular Substances; D009696:Nucleic Acids / Q000502:physiology* / Q000528:radiation effects; D011506:Proteins / Q000502:physiology* / Q000528:radiation effects; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D006133:Growth Substances; D046911:Macromolecular Substances; D009696:Nucleic Acids; D011506:Proteins