Wilms tumour in a patient with growth hormone replacement therapy.
Wilms tumour was found in a Japanese boy aged 5 years 9 months with isolated growth hormone (GH) deficiency and some congenital anomalies. He had received pituitary GH replacement therapy from the age of 2 years 1 month to 4 years 7 months and after a 1 year interval he received biosynthetic GH for 2 months until the tumour became clinically apparent. This was the sixth known patient with GH deficiency to develop a malignant neoplasm during or after GH replacement therapy and the first with a solid tumour in Japan since 1975, when treatment with pituitary GH for patients with GH deficiency was introduced.
Momoi
T
T
Department of Paediatrics, Kyoto University Faculty of Medicine, Japan.
Yamanaka
C
C
Yorifuji
T
T
Sasaki
H
H
Kaji
M
M
Akiyama
Y
Y
Inomata
Y
Y
Tanaka
K
K
Mikawa
H
H
D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology; D008297:Male; D011859:Radiography; D009396:Wilms Tumor / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology
D013006:Growth Hormone