title: A study of the anticholinergic activity of terfenadine in normal volunteers.
abstract: The anticholinergic effects of single doses of terfenadine, chlorpheniramine and atropine on salivary flow were compared with those of placebo in a double-blind crossover study in 21 normal adults. Salivary flow was measured immediately before administering study medications and 3 h after dosing, for the evaluation of anticholinergic activity. Mean salivary flow decreased significantly after administration of chlorpheniramine and atropine (P less than 0.01 and P less than 0.001, respectively), and was unchanged by terfenadine and placebo, indicating that terfenadine does not possess detectable anticholinergic activity. Mild drowsiness was reported by 57% and 29% of subjects who received chlorpheniramine and terfenadine, respectively.
authors.affiliation: Clinical Research Center, New Orleans, Louisiana 70122.
authors.forename: R
authors.initials: R
authors.lastname: Vargas
authors.forename: F G
authors.initials: FG
authors.lastname: McMahon
authors.forename: J R
authors.initials: JR
authors.lastname: Ryan
mesh_terms: D000328:Adult; D001285:Atropine / Q000009:adverse effects / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000494:pharmacology*; D002744:Chlorpheniramine / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010276:Parasympatholytics; D012016:Reference Values; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D016593:Terfenadine
chemical_list: D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D002744:Chlorpheniramine; D016593:Terfenadine; D001285:Atropine