Sensitivity of the renal adenylate cyclase receptor system to parathormone during the last third of pregnancy in the rat.
During the last third of pregnancy, the rat phospho-calcic metabolism is clearly modified. Sensitivity of the renal receptor to parathormone (PTH) was investigated over this period in the fetuses and their mothers. As early as day 16.5 of pregnancy, the fetal kidney is sensitive to bovine PTH (1-34) on the basis of cAMP production. Sensitivity declines on the last day of pregnancy. The newborn kidney showed a higher response to PTH 3 h after birth than after 24 h. The basal adenylate cyclase activity in renal membranes of maternal kidney does not change. The sensitivity to PTH and to fluoride both decreased on day 18.5. A desensitization process of the PTH receptor A-C system has to be studied in order to explain these results.
Gugi
B
B
Groupe de Recherche de Biologie du Développement, UER Médecine-Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Mallet
E
E
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000196:embryology / Q000201:enzymology / Q000378:metabolism*; D008566:Membranes / Q000201:enzymology / Q000378:metabolism; D010281:Parathyroid Hormone / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
D010281:Parathyroid Hormone; D006165:Guanylyl Imidodiphosphate; D012969:Sodium Fluoride; D000242:Cyclic AMP; D000262:Adenylyl Cyclases