Induction of rat liver gamma-glutamyltranspeptidase-positive foci by oral administration of 1-nitropyrene.
In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was observed with all the doses of 1-NP (1000, 500, 250 and 100 mg/kg body wt) used in the present experiment after 6 repeated intragastric (i.g.) intubations when accompanied by partial hepatectomy (PH) performed midway, but not after a single i.g. 1000 mg/kg body wt intubation plus PH. The potential for induction of foci by 1-NP, however, was far less than that by benzo[a]pyrene (B[a]P). The results thus suggested a weak but substantial initiation activity for 1-NP in the rat liver when given orally, particularly with repeated doses.
Denda
A
A
Department of Oncological Pathology, Nara Medical College, Japan.
Tsutsumi
M
M
Tsujiuchi
T
T
Eimoto
H
H
Konishi
Y
Y
Sato
S
S
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology*; D011721:Pyrenes / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D002273:Carcinogens; D011721:Pyrenes; D005723:gamma-Glutamyltransferase; C032668:1-nitropyrene