A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1.
The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.
Butterfield
K
K
Department of Medicine, Stanford University School of Medicine, California 94305.
Fathman
C G
CG
Budd
R C
RC
D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000145:classification*; D005434:Flow Cytometry; D007156:Immunologic Memory; D051379:Mice; D016201:Receptors, Lymphocyte Homing; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000954:Antigens, Surface; D016201:Receptors, Lymphocyte Homing