Progression to AIDS in the majority of asymptomatic HIV-infected people.
Sixty-eight asymptomatic HIV-seropositive people with a CD4 lymphocyte count above 400/mm3 at the first examination were followed up every year over a 3-year period, by monitoring the biological markers of AIDS (CD4 lymphocyte decrease, loss of anti-p24 or anti-p17 antibodies, positive p24 antigenemia, increase of erythrocyte sedimentation rate, and of serum levels of immunoglobulin G. immunoglobulin A, neopterin and beta 2-microglobulin). The percentages of subjects positive for at least one marker at the first, second, third and fourth examinations were 66, 88, 94 and 97%, respectively. The increase in the number of markers with time was significant (chi-square test; P less than 0.001). This increase suggests a progression to AIDS in the majority of asymptomatic seropositive subjects, even those without a decreased CD4 lymphocyte count.
Lefrère
J J
JJ
Institut National de Transfusion Sangvine, Paris, France.
Lambin
P
P
Couroucé
A M
AM
Doinel
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000032:analysis; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015658:HIV Infections / Q000145:classification / Q000276:immunology / Q000503:physiopathology*; D006679:HIV Seropositivity / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
D015415:Biomarkers; D015483:HIV Antibodies; D015488:HIV Antigens