[Parvovirus-induced aplastic crisis in a child with hereditary spherocytosis: studies on the mechanisms of hemopoietic suppression].
A 4 4/12-year-old girl with hereditary spherocytosis (HS) who presented with an aplastic crisis during a human parvovirus (HPV) B19 infection is reported. IgM and IgG antibodies to the HPVB19 and HPV19 DNA were detected. Each of Leu 7+, Leu 11+ and HLA-DR+ cells increased. OKT4/OKT8 ratio decreased to 0.71. In order to investigate the mechanism of aplastic crisis, we used an in vitro culture technique for erythroid and granulocyte-macrophage progenitor cells (BFU-E, CFU-E and CFU-C). The patient's HPV19 DNA-containing aplastic phase serum inhibited the formation of BFU-E, CFU-E and CFU-C. After removal of the adherent cells from the aplastic phase bone marrow, the numbers of BFU-E significantly increased. These results suggest that aplastic crisis of the patient with HS was caused by HPVB19, and that monocytes-macrophages and NK cells played an important role in the pathogenesis of aplastic crisis.
Saitoh
H
H
Horino
N
N
Ohie
T
T
Sejima
H
H
Mori
C
C
D000741:Anemia, Aplastic / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D010322:Parvoviridae Infections / Q000150:complications*; D013103:Spherocytosis, Hereditary / Q000150:complications*