99Tcm-diastereomeric dimercaptosuccinic acid complexes: comparison of their biodistribution.
The biodistribution of two stereoisomeric 99Tcm complexes derived from diastereomeric dimercaptosuccinic acids (DMSA), 99Tcm-dl-DMSA and 99Tcm-meso-DMSA, was examined in sarcoma 180 tumour-bearing mice. The biodistribution pattern of meso-complex was not significantly different from 99Tc(V)m-DMSA, a new tumour imaging agent, while the dl-complex did not show the osteotropic property observed in meso- and 99Tc(V)m-DMSA complexes. The ratio of tumour to blood was superior for the 99Tcm-dl-DMSA (2.68) over the 99Tcm-meso-DMSA (1.25) at 3 h, and the ratio was reversed at 6 h, 3.13 to 4.28. The results indicate that dl-complex is of importance for the possible use in tumour imaging.
Awh
O D
OD
Department of Chemistry, Korea Advanced Institute of Science and Technology, Seoul.
Kim
J R
JR
Shim
S C
SC
D000818:Animals; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging*; D013237:Stereoisomerism; D004113:Succimer / Q000493:pharmacokinetics*; D013438:Sulfhydryl Compounds / Q000493:pharmacokinetics*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods*
D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer