[Interleukin-1-like factor from human B-lymphocytes transformed by the Epstein-Barr virus].
The NC-37, EBV-transformed human B-lymphoblastoid cell line spontaneously produces interleukin (IL)-1-like factor, which is able to stimulate proliferation of mouse thymocytes and human fibroblasts. The IL-1-like factor production can be enhanced by prodigiozan and by the conditioned medium of human peripheral blood mononuclear cells. The NC-37 cells have a membrane-associated form of IL-1-like factor also. The molecular mass of the intracellular precursor of this factor determined by gel-filtration is 35-40 kDa, and that of the secretory form--18-20 kDa. The secretory form has the following isoelectric points: 4.5; 6.8; 7.2-8.4.
Kotov
A Iu
AIu
Simbirtsev
A S
AS
Perumov
N D
ND
Ketlinskiĭ
S A
SA
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008970:Molecular Weight; D013268:Stimulation, Chemical
D007375:Interleukin-1
Interleĭkin-1-podobnyĭ faktor iz B-limfotsitov cheloveka, transformirovannykh virusom Epshteĭna--Barra.