title: [Studies of solutions with various branched-chain amino acid contents on protein metabolism in the postoperative period. 1. A 15N tracer kinetic animal model for evaluating the effect of parenteral amino acid administration on nitrogen metabolism].
abstract: We were able to estimate nitrogen or protein metabolism on the basis of a 15N metabolic model that delivered a high amount of data during a parenteral nutrition period over 72 h. We describe the basic principles of the necessary N or 15N-analyses in blood, as well as in sera, in urine, in tissues of selected organs and in hepatocytes. This 15N-metabolic model allows the estimation of the utilization of amino acid infusion solutions. Because of the great similarity of parameters of the N or protein turnover between man and pig it is possible to provide relevant information for the clinical practice regarding amino acid infusion solutions.
authors.affiliation: Chirurgische Klinik Bezirkskrankenhauses St. Georg Leipzig, DDR.
authors.forename: R
authors.initials: R
authors.lastname: Matkowitz
authors.forename: W
authors.initials: W
authors.lastname: Hartig
authors.forename: R
authors.initials: R
authors.lastname: Ritter
authors.forename: H
authors.initials: H
authors.lastname: Betzler
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D009584:Nitrogen / Q000378:metabolism*; D009590:Nitrogen Radioisotopes; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000378:metabolism*; D012016:Reference Values; D013552:Swine; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000597:Amino Acids, Branched-Chain; D001798:Blood Proteins; D009590:Nitrogen Radioisotopes; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009584:Nitrogen
vernacular_title: Untersuchungen von Lösungen mit differentem Gehalt an BCAA auf den Proteinstoffwechsel im postoperativen Verlauf. 1. Mitteilung: 15N-Tracer-kinetisches Stoffwechsel-Tiermodell zur Beurteilung der Wirkung parenteraler Aminosäuren-Zufuhr auf den Stickstoff-Stoffwechsel.