title: Paraneoplastic subacute cerebellar degeneration in Hodgkin's disease. Report of three cases and review of the literature.
abstract: 12 cases of paraneoplastic cerebellar degeneration with Hodgkin's disease have so far been reported. Three additional patients (Stage II-IA/IIA/IIIB) are presented. Although CT and MR-imaging (MRI) revealed a marked cortical atrophy of the cerebellum, there was no evidence of direct brain involvement. After irradiation and chemotherapy all patients showed a complete remission. There was no evidence of primary disease after an observation period of 3/2/5 years. Cerebellar symptoms also showed a partial remission. As compared to the literature, our treatment appears to be more favorable, probably due to the fact, that therapy was more aggressive than usual.
authors.affiliation: Department of Neurology, University Hospital Münster, FRG.
authors.forename: H P
authors.initials: HP
authors.lastname: Schlake
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
authors.forename: K H
authors.initials: KH
authors.lastname: Grotemeyer
authors.forename: R
authors.initials: R
authors.lastname: Pötter
mesh_terms: D000328:Adult; D001284:Atrophy; D002526:Cerebellar Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology*