Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection.
To examine whether cytomegalovirus (CMV) infection could accelerate progression of human immunodeficiency virus (HIV) infection to AIDS, serological studies were done on 108 HIV-infected haemophiliacs. In the 1.3-9 years from time of first recognised HIV seroconversion, the age-adjusted risk of CDC group IV disease in CMV-seropositive patients was 2.5 times that in CMV-seronegative patients. CMV-seropositive patients were also more likely to have detectable p24 antigenaemia. Survival analysis showed that CMV-seropositive patients were at greater risk of HIV disease than CMV-seronegative patients from about 2 years after HIV seroconversion. Thus CMV infection is associated with a more rapid progression to HIV disease.
Webster
A
A
Department of Virology, Royal Free Hospital, School of Medicine, London.
Lee
C A
CA
Cook
D G
DG
Grundy
J E
JE
Emery
V C
VC
Kernoff
P B
PB
Griffiths
P D
PD
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D014775:Virus Activation