Gold-naproxen pneumonitis. A toxic drug interaction?
A patient with rheumatoid arthritis developed restrictive lung disease and blood eosinophilia. Gold pneumonitis was suspected but the patient did not improve until naproxen was discontinued as well. Lymphocyte transformation studies suggested hypersensitivity to gold. We hypothesize that naproxen unmasked and perpetuated the manifestations of gold hypersensitivity in our patient.
McFadden
R G
RG
Department of Medicine, Lawson Research Institute of St. Joseph's Health Centre, London, Canada.
Fraher
L J
LJ
Thompson
J M
JM
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000276:immunology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use
D009288:Naproxen; D006046:Gold