Predisposition to familial osteoarthrosis linked to type II collagen gene.
The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.
Palotie
A
A
Laboratory of Molecular Genetics, National Public Health Institute, Helsinki, Finland.
Väisänen
P
P
Ott
J
J
Ryhänen
L
L
Elima
K
K
Vikkula
M
M
Cheah
K
K
Vuorio
E
E
Peltonen
L
L
D000328:Adult; D000367:Age Factors; D002881:Chromosomes, Human, Pair 12; D003094:Collagen / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011859:Radiography; D012720:Severity of Illness Index
D003094:Collagen; D004247:DNA