title: Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes.
abstract: Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.
authors.affiliation: Department of Psychiatry and Neurochemistry, Lund University, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Simonsson
authors.forename: E
authors.initials: E
authors.lastname: Hansson
authors.forename: C
authors.initials: C
authors.lastname: Alling
mesh_terms: D001253:Astrocytes / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D006868:Hydrolysis; D007295:Inositol Phosphates / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D007295:Inositol Phosphates; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D011985:Receptors, Serotonin; D000431:Ethanol; D011493:Protein Kinase C