Effects of aspirin and paracetamol on ATPases of human fetal brain: an in vitro study.
In vitro effects of aspirin and paracetamol at the doses 200, 400, 600, 800 nmole/mg protein on ATPases activity were studied in the cerebrum and cerebellum of human fetus covering the age range from 10 weeks to 32 weeks of gestation. Both aspirin and paracetamol inhibit Na+K+ ATPase and Mg2+ ATPase in a dose dependent manner. The inhibition of Na+K+ ATPase and Mg2+ ATPase activity which may affect the release and uptake of biogenic amines in CNS, hinders the maturation of human fetal brain.
Sarkar
A K
AK
Chakraborti
A
A
Saha
U K
UK
Bose
S K
SK
Sengupta
D
D
D000082:Acetaminophen / Q000494:pharmacology*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology*; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000082:Acetaminophen; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D001241:Aspirin