[Effect of progestin therapy on the level of cytoplasmic receptors in patients with cancer of the corpus uteri].
Correlations were identified between tumor morphobiochemical characteristics and basic parameters of reproductive homeostasis in 256 cases of endometrial carcinoma. A correlation was established between the levels of cytoplasmic receptors to estradiol (ER) and progesterone (PR), on the one hand, and morphological differentiation and spontaneous secretion in tumor tissue, on the other. A direct correlation was found between ER and metastatic spread to regional lymph nodes, and no correlation--between ER and PR and major parameters of reproductive homeostasis. A significant decrease in ER, PR, gonadotropins, estradiol and colpocytological reaction indexes followed hormone therapy with hydroxyprogesterone capronate and medroxyprogesterone acetate. The criteria of endometrial carcinoma patients sensitivity to progestin therapy were as follows: ER and PR levels--more than 30.0 fmol/mg protein, estradiol--more than 30-50 pg/ml and colpocytological index--over 40%.
Vishnevskiĭ
A S
AS
Bokhman
Ia V
IaV
Tsyrlina
E V
EV
Bobrov
Iu F
IuF
Fel'dkoren
B I
BI
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003593:Cytoplasm / Q000032:analysis / Q000187:drug effects*; D004341:Drug Evaluation; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008875:Middle Aged; D011300:Preoperative Care; D011956:Receptors, Cell Surface / Q000032:analysis / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects; D014594:Uterine Neoplasms / Q000032:analysis / Q000188:drug therapy*; D014626:Vaginal Smears
D000970:Antineoplastic Agents; D006908:Hydroxyprogesterones; D011956:Receptors, Cell Surface; D000077713:17 alpha-Hydroxyprogesterone Caproate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone
Vliianie progestinoterapii na uroven' tsitoplazmaticheskikh retseptorov u bol'nykh rakom tela matki.