Voltage-dependent transient calcium currents in freshly dissociated capillary endothelial cells.
Dissociated capillary endothelial cells display a voltage-dependent Ca current activating around the resting potential. The initial transient component of the current corresponds to a Ca channel of the T type. Some cells also display a plateau component corresponding to a distinct dihydropyridine-sensitive Ca channel. Depolarization induced by high external K+ elicits an increase in cytoplasmic Ca concentration. Confluent cells have been found to express the same Ca permeabilities.
Bossu
J L
JL
Laboratoire d'Etude des Régulations Physiologiques, Centre National de la Recherche Scientifique, Strasbourg, France.
Feltz
A
A
Rodeau
J L
JL
Tanzi
F
F
D000313:Adrenal Medulla / Q000502:physiology; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology*; D002196:Capillaries / Q000502:physiology; D002417:Cattle; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D004553:Electric Conductivity; D004594:Electrophysiology / Q000379:methods; D004730:Endothelium, Vascular / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects
D015220:Calcium Channels; D000584:Amiloride; D002118:Calcium