title: An outbreak of gastroenteritis associated with acute rotaviral infection in schoolchildren.
abstract: In April 1988 a large outbreak of group C rotavirus infection associated with acute gastroenteritis occurred among schoolchildren and their teachers simultaneously at seven elementary schools in Fukui city, Japan. Of 3,102, 675 (21.8%) became ill. Clinical symptoms were mild, predominantly abdominal pain and vomiting, with diarrhea reported in only 27.6%. The outbreak subsided within 2 d. No pathogenic bacteria were found in fecal specimens; the virus particles detected by electron microscopy were morphologically indistinguishable from conventional infantile rotavirus. Immune electron microscopy showed that these virions formed large aggregates with convalescent serum and with the reference serum specific to group C rotavirus. Polyacrylamide gel electrophoresis showed similar RNA patterns for virus from this outbreak and typical group C rotavirus.
authors.affiliation: Department of Microbiology, Fukui Medical School, Fukui Prefectural Institute of Public Health, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: S
authors.initials: S
authors.lastname: Nakata
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000208:Acute Disease; D000328:Adult; D002648:Child; D004196:Disease Outbreaks; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D005506:Food Contamination; D005759:Gastroenteritis / Q000453:epidemiology* / Q000382:microbiology; D006386:Hemagglutination Tests; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan / Q000453:epidemiology; D008854:Microscopy, Electron; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D012367:RNA, Viral