Hormonal modulation of the rat mammary gland gamma-glutamyltranspeptidase.
1. The in vivo effect of estradiol and domperidone (a hypophysis stimulator of prolactin secretion) in immature ovariectomized-adrenalectomized and hypophysectomized rat mammary gland was studied. 2. gamma-Glutamyltranspeptidase activity was used to evaluate the role of estradiol in the specific response of the gland to prolactin. 3. Our results suggest that the activity of gamma-glutamyltranspeptidase, like casein and lactose synthetase, is part of the specific response of the gland to prolactin.
Ríos
M
M
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
Puente
J
J
Sapag-Hagar
M
M
D000315:Adrenalectomy; D000818:Animals; D004247:DNA / Q000032:analysis; D004294:Domperidone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007016:Hypophysectomy; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000201:enzymology*; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D004958:Estradiol; D004294:Domperidone; D004247:DNA; D005723:gamma-Glutamyltransferase