[Value of the CRF test in primary and secondary adrenal insufficiency].
The ACTH and cortisol responses after CRF administration were studied in 21 patients with adrenal failure and compared with those obtained in 15 control subjects. In patients with Addison's disease, cortisol and ACTH responses were respectively abolished or excessive. In patients with secondary adrenal failure, a unique bolus injection of CRF allows the differentiation between pituitary or hypothalamic secretory defect. With regard to previous reports, the usefulness of CRF test in primary and secondary adrenal failure is stressed.
Tabarin
A
A
Service d'Endocrinologie, Hôpital Saint-André, Bordeaux.
Corcuff
B
B
Dauthribes
M
M
San-Galli
F
F
Cochet
C
C
Guerin
J
J
Roger
P
P
D000224:Addison Disease / Q000097:blood; D000309:Adrenal Insufficiency / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone
Intérêt du test au CRF dans l'insuffisance surrénalienne primitive et secondaire.