In vitro activity of nalidixic acid and its iron (III) complex on Entamoeba histolytica.
The in vitro activity of the antibacterial agent nalidixic acid (HNal) and its iron (III) complex (FeNal) against Entamoeba histolytica HM1 strain trophozoites in axenic or monoxenic (associated with Clostridium symbiosum) cultures was investigated. Using a dilution test with TYI-S-33 medium, this protozoan was found to be susceptible to both drugs, but FeNal showed amoebicidal activity only at concentrations higher than those used with HNal.
Anaya-Velázquez
F
F
Instituto de Investigación en Biología Experimental, Universidad de Guanajuato, Mexico.
Padilla-Vaca
F
F
Arias-Negrete
S
S
Mendoza-Díaz
G
G
D000818:Animals; D003013:Clostridium / Q000187:drug effects / Q000254:growth & development; D004748:Entamoeba histolytica / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005296:Ferrous Compounds / Q000494:pharmacology*; D006801:Humans; D009268:Nalidixic Acid / Q000494:pharmacology*
D005296:Ferrous Compounds; D009268:Nalidixic Acid