Beta-adrenoceptor-effector system of the human macrophage U937 cell line.
Like animal peritoneal macrophages, cells of the U937 human macrophage cell line were found to possess beta-adrenoceptors with a density of approximately 1400 sites/cell of the beta 2-subtype. Agonist occupancy increased adenylate cyclase activity and lead to rapid sequestration of cell surface receptors, functional desensitization, and receptor downregulation. Thus human macrophages possess beta-adrenoceptors and the U937 cell provides a system for studying the interactions of this receptor with macrophage immune function.
Liggett
S B
SB
Pulmonary Division, Washington University School of Medicine, St. Louis, MO.
D000262:Adenylyl Cyclases / Q000378:metabolism; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D010869:Pindolol / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013237:Stereoisomerism
D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D010869:Pindolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases