Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells.
Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus-infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.
Horsch
A
A
Biologisches Institut, Universität Stuttgart, FRG.
Martins de Sa
C
C
Dineva
B
B
Spindler
E
E
Schmid
H P
HP
D000256:Adenoviridae / Q000235:genetics / Q000502:physiology*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005914:Globins / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000378:metabolism; D011132:Polyribosomes / Q000032:analysis; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D011817:Rabbits; D012261:Ribonucleoproteins / Q000378:metabolism*
D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral; D012261:Ribonucleoproteins; D011061:Poly A; D005914:Globins