Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney.
The participation of beta 1-adrenoceptor on renin secretion was studied in perfused rat kidney. Administration of propranolol, inhibited the renin release mediated by isoproterenol. Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor.
Haro
J M
JM
Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Granada, Spain.
Vargas
F
F
Castillo
M A
MA
García-Torres
L
L
Acuña
D
D
D000319:Adrenergic beta-Antagonists / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012083:Renin / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013045:Species Specificity
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D012083:Renin; D008790:Metoprolol; D007545:Isoproterenol; D011217:Practolol