Disturbances of transmembranous sodium transport systems induced by ethanol in human erythrocytes. An approach to the pressor effect of alcohol.
Several epidemiological and clinical studies have established a clear association between alcohol consumption and hypertension. The mechanism of the pressor effect of ethanol is not well understood. We studied the in vitro effects of increasing amounts of ethanol on different Na+ transport systems from human erythrocytes. Ethanol at concentrations higher than 32 mmol/L stimulated ouabain-sensitive Na+ efflux, the Na+ efflux depending on the Na+:Li+ countertransport and Na+ leak. At the same concentrations, ethanol inhibited bumetanide-sensitive Na+ efflux. We conclude that, with the exception of Na+-K+ pump, alcohol-induced alterations and those observed in erythrocytes from essential hypertensives may overlap. Therefore, alcohol consumption could potentiate those genetic abnormalities of Na+ transport and contribute to the pathogenesis of essential hypertension.
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Department of Internal Medicine, Hospital Clinico, School of Medicine, University of Barcelona, Spain.
Garay
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RP
Aguilera
M T
MT
De la Sierra
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Urbano-Márquez
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D017920:Antiporters; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002352:Carrier Proteins / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D015221:Potassium Channels / Q000187:drug effects; D012964:Sodium / Q000097:blood*; D015222:Sodium Channels / Q000187:drug effects; D028021:Sodium-Potassium-Chloride Symporters
D017920:Antiporters; D002352:Carrier Proteins; D015221:Potassium Channels; D015222:Sodium Channels; D028021:Sodium-Potassium-Chloride Symporters; C045885:sodium-lithium countertransporter; D000431:Ethanol; D012964:Sodium; D011188:Potassium