Monoclonal antibodies to type D retrovirus (SRV-2).
Monoclonal antibodies (MoAbs) to the major gag core protein p27 and a viral protein p44 of type D retrovirus (SRV-2) were produced and used in the detection of SRV-2 antigens in infected Raji cells and in tissues from macaques with simian acquired immunodeficiency syndrome (SAIDS) and retroperitoneal fibromatosis (RF). Anti-p44 MoAb showed inhibition of syncytium formation by both SRV-1- and SRV-2-infected Raji cells.
Tsai
C C
CC
Department of Pathology, St. Louis University School of Medicine, MO.
Tsai
C C
CC
Sligh
J M
JM
Yarnall
M
M
Follis
K E
KE
Roodman
S T
ST
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis* / Q000276:immunology; D015153:Blotting, Western; D002460:Cell Line; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D015683:Gene Products, gag; D006825:Hybridomas; D007150:Immunohistochemistry; D009500:Neutralization Tests; D012191:Retroviridae Proteins / Q000276:immunology; D015301:Retroviruses, Simian / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D015683:Gene Products, gag; D012191:Retroviridae Proteins