[The effect of N-(1-methyldodecyl)-N,N-dimethylaminoxide on the conformation of hydrocarbon chains in phospholipid bilayers isolated from Escherichia coli].
Using the method of ESR spectroscopy of stearic acid spin probes labeled by the doxyl group on the 12th or 16th carbon, it has been found that bactericidal surfactant N-(1-methyldodecyl)-N,N-dimethylamine oxide increases the effective energy difference between trans- and gauche conformers Eg and decreases the probability of gauche conformers formation pg in lipid hydrocarbon chains in multilamellar liposomes prepared from Escherichia coli-isolated phospholipids, at low surfactant concentrations. Above the surfactant: phospholipid molar ratio of 1:14 to 1:17, the value of Eg decreases and that of pg increases. The results are interpreted using the cluster model of lipid bilayer. At low concentrations the surfactant molecules are inserted into the dynamical defects between the clusters, thereby increasing the packing density of chains in the bilayer. At high concentrations the surfactant molecules penetrate into the clusters perturbing the dense packing of chains in clusters.
Balgavy
P
P
Shershen'
F
F
Leitmanova
A
A
Devinski
F
F
Mlinarchik
D
D
D004123:Dimethylamines / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D008051:Lipid Bilayers; D008433:Mathematics; D008968:Molecular Conformation; D010743:Phospholipids; D013501:Surface-Active Agents / Q000494:pharmacology*
D004123:Dimethylamines; D008051:Lipid Bilayers; D010743:Phospholipids; D013501:Surface-Active Agents; C019353:N,N-dimethyl-1-methyldodecylamine oxide
Vliianie N-(metildodetsil)-N,N-dimetilaminoksida na konformatsiiu uglevodorodnykh tsepeĭ v bisloe fosfolipidov, izolirovannykh iz Escherichia coli.