title: Fibroblast and myofibroblast participation in malignant fibrous histiocytoma (MFH) of bone. Ultrastructural study of eight cases with immunohistochemical support.
abstract: Eight malignant fibrous histiocytomas (MFH) of bone were studied with immunohistochemistry and electron microscopy. Ultrastructurally, fibroblasts and myofibroblasts were the main tumor cells in four cases and abundant in two other cases; these cells showed immunohistochemical positivity to alpha 1-antitrypsin, vimentin and anti-muscle antigen (HHF 35). Moreover, histiocytic-like tumor cells were electron-microscopically detected in four cases, being the main tumor cell type in two of the cases; immunohistochemically these cells expressed positivity to alpha-1-antichymotrypsin (A1ACT), alpha-1-antitrypsin (A1AT) and vimentin. Present results confirm the cellular heterogeneity of MFH of bone, in which fibroblasts and myofibroblasts transformed cells play a histogenetical role, suggesting the existence of close links with classic fibrosarcoma of bone.
authors.affiliation: Dept. of Pathology, Medical School, University of Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Martorell
authors.forename: C
authors.initials: C
authors.lastname: Calabuig
authors.forename: A
authors.initials: A
authors.lastname: Peydro-Olaya
authors.forename: A
authors.initials: A
authors.lastname: Llombart-Bosch
authors.forename: M J
authors.initials: MJ
authors.lastname: Terrier-Lacombe
authors.forename: G
authors.initials: G
authors.lastname: Contesso
mesh_terms: D000199:Actins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D000199:Actins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin