Transfer of DOPA from the sympatho-adrenal system to the pancreas, liver and kidney via the blood circulation.
The concentration of 3,4-dihydroxyphenylalanine (DOPA) was low in the pancreas, liver, kidney, spleen, salivary glands, heart and adrenal glands of untreated mice, but increased following inhibition of DOPA decarboxylase by 3-hydroxybenzylhydrazine. The ratio of the accumulation of DOPA to the concentration of noradrenaline (i.e. the density of sympathetic nerves) was greater in the kidney, liver and, particularly, pancreas than in the other organs studied, suggesting that DOPA occurred outside sympathetic nerves in these organs. The tyrosine hydroxylase inhibitor alpha-methyltyrosine almost completely inhibited the accumulation of DOPA in all organs. The DOPA accumulation was enhanced in all organs by the alpha-adrenoceptor antagonists phentolamine and yohimbine. The results indicate that the DOPA was formed in the sympatho-adrenal system. In the pancreas, liver and kidney, most of the DOPA accumulated might have been formed outside these organs and transferred there via the bloodstream.
Andén
N E
NE
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Grabowska-Andén
M
M
Schwieler
J
J
D000311:Adrenal Glands / Q000378:metabolism*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010179:Pancreas / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism*; D019805:alpha-Methyltyrosine
D000317:Adrenergic alpha-Antagonists; D006834:Hydrazines; D008781:Methyltyrosines; D004295:Dihydroxyphenylalanine; D019805:alpha-Methyltyrosine; C004297:3-hydroxybenzylhydrazine