[The effect of carbacholine on spontaneous quantum secretion of a mediator from frog motor nerve endings in the presence of ouabain and in a potassium-free medium].
The carbacholine (Cch) effect on the frequency of miniature end-plate potentials (MEPP) has been studied in the frog muscle in the presence of ouabain and in the potassium-free solution. The depressing presynaptic effect of Cch on the MEPP frequency was eliminated by ouabain, whereas the inactivation of ATPase by the potassium-free solution did not affect the degree of the MEPP frequency decrease. The possibility of the spontaneous quantal release regulation in cholinomimetic drugs by means of the ouabain-sensitive mechanism not related to the pumping function of the Na+, K+ and ATPase active transport is discussed.
Nikol'skiĭ
E E
EE
Bukharaeva
E A
EA
Badrutdinov
L R
LR
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009046:Motor Neurons / Q000187:drug effects* / Q000378:metabolism; D009411:Nerve Endings / Q000187:drug effects* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D011896:Rana temporaria
D018377:Neurotransmitter Agents; D010042:Ouabain; D002217:Carbachol; D011188:Potassium
Vliiianie karbakholina na spontannuiu kvantovuiu sekretsiiu mediatora iz dvigatel'nykh nervnykh okonchaniĭ liagushki v prisutstvii oubaina i v beskalievoĭ srede.