title: [An uncommon form of thymidine kinase in breast cancers].
abstract: An unusual form of thymidine kinase has been found in cytosols from breast cancers. It differs from the adult and fetal isoenzymes of thymidine kinase in so far as its activity could not be isolated from that of thymidylate kinase. Following sucrose density gradients, electrofocusing, ion exchange chromatography or molecular sieving, both activities appeared as a single peak. These facts suggest that they could be attributed to a single multifunctional protein.
authors.affiliation: Centre régional de Recherche en Endocrinologie, Faculté de Médecine-Pharmacie, Rennes.
authors.forename: A
authors.initials: A
authors.lastname: Madec-Baron
authors.forename: G
authors.initials: G
authors.lastname: Baron
authors.forename: S
authors.initials: S
authors.lastname: Sampérez
authors.forename: P
authors.initials: P
authors.lastname: Jouan
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology*; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002846:Chromatography, Affinity; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000302:isolation & purification* / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism; D013937:Thymidine Kinase / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D007527:Isoenzymes; D013937:Thymidine Kinase; D009703:Nucleoside-Phosphate Kinase
vernacular_title: Mise en évidence d'une forme inédite de la thymidine kinase dans les cancers du sein.