title: Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos.
abstract: The expression of the Xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: A
authors.initials: A
authors.lastname: Ruiz i Altaba
authors.forename: D A
authors.initials: DA
authors.lastname: Melton
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004627:Embryonic Induction; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D006133:Growth Substances / Q000502:physiology*; D008648:Mesoderm / Q000502:physiology; D009024:Morphogenesis; D012333:RNA, Messenger / Q000235:genetics; D014982:Xenopus laevis / Q000196:embryology*
chemical_list: D006133:Growth Substances; D012333:RNA, Messenger