Cross-talk between receptors coupled to calcium currents in adult but not neonatal rat sensory neurons.
In adult rat sensory neurons Ca2+ currents were studied with the whole-cell patch-clamp technique. Two categories of neuromodulators, known to activate different 2nd messenger systems: 1) angiotensin II (AII), bovine serum albumin (BSA), Acetylcholine (ACh) and 2) GABA, stimulated the low-voltage activated (LVA) and inhibited the high voltage activated (HVA) currents, respectively. The simultaneous application of the two types of drugs failed to inhibit the HVA current via a putative cross-talk between the two 2nd messengers.
Wanke
E
E
Dept. General Physiology and Biochemistry, University of Milan, Italy.
Becchetti
A
A
Bertollini
L
L
Ferroni
A
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D015220:Calcium Channels / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D015290:Second Messenger Systems
D015220:Calcium Channels