title: The role of ifosfamide and cyclophosphamide in the multi-modality treatment after surgery for cure for small-cell bronchial carcinomas (SCLC).
abstract: For the optimisation of the therapy for small cell bronchial carcinomas (SCLC), surgery is used to eliminate the primary tumor and its regional lymph nodes and chemo- and radiotherapy for the general treatment of micrometastasis. After patho-histological examination of the operation specimen, randomization for two arms is performed for a standard chemotherapy (CAV) or a sequential chemotherapy using three different drug combinations. Thereafter all disease-free patients receive prophylactic cranial irradiation (PCI). Preliminary evaluations in December 1987, of 112 patients from 19 cooperating departments show that the survival rate projected for 2 yr of 43 patients at stage pT1-3 N0 M0 is 76%, of 43 patients at stage pT1-3 N1 M0 it is 63% and of 26 patients at stage pT1-3 N2 M0 it is 38%.
authors.affiliation: Institute for Epidemiology of Neoplasms of the University of Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Karrer
authors.forename: H
authors.initials: H
authors.lastname: Denck
authors.forename: H
authors.initials: H
authors.lastname: Karnicka-Mlodkowska
authors.forename: P
authors.initials: P
authors.lastname: Drings
authors.forename: J
authors.initials: J
authors.lastname: Orel
authors.forename: G M
authors.initials: GM
authors.lastname: Salzer
authors.forename: M
authors.initials: M
authors.lastname: Thermann
authors.forename: A
authors.initials: A
authors.lastname: Lattuneddu
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: E
authors.initials: E
authors.lastname: Hata
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001984:Bronchial Neoplasms / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D015337:Multicenter Studies as Topic; D011182:Postoperative Care; D011897:Random Allocation
chemical_list: D003520:Cyclophosphamide; D007069:Ifosfamide