[Comparative evaluation of the effect of carbidine and levamisole on the E-rosette-forming activity of the lymphocytes in alcoholic intoxication].
The E-rosette formation activity of lymphocytes in human alcoholics treated with carbidine was studied. In experimental alcohol intoxication in animals the effect of carbidine on the E-rosette formation was compared with that of levamisole. The effects of the both drugs in the in vitro experiments were studied as well. The use of carbidine for treating alcoholism was shown to produce changes in the E-rosette formation indicating possible immunodulating properties of the drug. In experimental conditions of the immune response to ram erythrocytes during alcoholic intoxication the inhibitory effect of carbidine on the E-rosette formation was more pronounced. In the in vitro conditions carbidine changes the E-rosette formation in alcoholics similarly to levamisole suggesting the immunomodulating properties of carbidine.
Proskuriakova
T V
TV
Gurtovenko
V M
VM
Gorshkova
E P
EP
D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002243:Carbolines / Q000627:therapeutic use*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007978:Levamisole / Q000627:therapeutic use*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation
D014150:Antipsychotic Agents; D002243:Carbolines; D007978:Levamisole; C100106:dicarbine
Sravnitel'naia otsenka vliianiia karbidina i levamizola na E-rozetkoobrazuiushchuiu aktivnost' limfotsitov pri alkogol'noĭ intoksikatsii.