Serological response to P-fimbriae of Escherichia coli in patients with urinary tract infections.
The antibody response to P-fimbriae of Escherichia coli in patients with upper urinary tract infections was investigated. In the sera of patients with pyelonephritis obtained at the initial visit to hospital (3 to 7 days after the onset of symptoms), a high incidence of antibodies to P-fimbriae was detected (12 out of 14 patients). P-fimbriated Escherichia coli strains were isolated from urine samples in all of these antibody-positive patients. Antibodies detected by ELISA using purified antigen were essentially IgG and specifically recognized P-fimbriae. These antibodies inhibited completely, or in some cases partially, mannose-resistant hemagglutination with P-fimbriated Escherichia coli.
Agata
N
N
Department of Bacteriology, Nagoya University School of Medicine, Japan.
Ohta
M
M
Miyazawa
H
H
Mori
M
M
Kido
N
N
Kato
N
N
D000907:Antibodies, Bacterial / Q000032:analysis*; D003556:Cystitis / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D006801:Humans; D011704:Pyelonephritis / Q000276:immunology*
D000907:Antibodies, Bacterial