Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers.
The significance of increased atrial natriuretic factor (ANF) in relation to blood pressure and age is still controversial. We investigated the influence of blood pressure, age, and some other variables on ANF and its putative second messenger, cGMP. Samples for ANF and cGMP detection were taken from 124 ostensibly healthy individuals who were donating blood. Samples were also collected from 27 volunteers before and after blood donation, to study the influence of bleeding. During blood donation, ANF increased from 78.9 to 87.4 ng/L (P = 0.0035), whereas cGMP remained unchanged. ANF concentrations in 124 healthy individuals, corrected for the influence of bleeding, were 61.5 (SD 26.1) ng/L, with a 95% confidence interval of 10.0 to 112.1 ng/L. Mean cGMP concentrations in plasma were 2.9 (SD 1.45) nmol/L, with a 95% confidence interval of 0.4 to 5.75 nmol/L. Multivariance analysis revealed no significant influence of blood pressure, age, heart rate, or sex on concentrations of either ANF or cGMP in plasma.
Wencker
M
M
Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Austria.
Hauptlorenz
S
S
Moll
W
W
Puschendorf
B
B
D000328:Adult; D000367:Age Factors; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001782:Blood Donors; D001794:Blood Pressure; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP