KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Mollisia ventosa.
Novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase were isolated from the culture broth of a fungus, Mollisia ventosa KAC-1148. They were designated as KS-504a, KS-504b and KS-504d. A degradative product of KS-504a, called KS-504e, was also isolated and found to inhibit the enzyme. The 50% inhibitory concentration (IC50) values of KS-504a, KS-504b, KS-504d and KS-504e for bovine brain enzyme were 122, 109, greater than 500 and 139 microM, respectively.
Nakanishi
S
S
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Ando
K
K
Kawamoto
I
I
Yasuzawa
T
T
Sano
H
H
Kase
H
H
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002118:Calcium / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D003517:Cyclopentanes / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D005658:Fungi / Q000032:analysis; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; C063094:KS 504d; C063096:KS 504e; C063093:KS 504a; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D002118:Calcium