title: Group A streptococci bind human plasmin but not other structurally related proteins.
abstract: Certain group A streptococci are known to possess a receptor for the human enzyme plasmin. Plasmin is a member of a super gene family that includes other serine proteases and kringle containing proteins. In this study we have examined the interaction of a group A streptococcus with structurally related proteins, including plasmin, glu-plasminogen, tissue plasminogen activator, kallikrein, factor XII, prothrombin, thrombin, trypsin, and urokinase. Our studies indicate that only the key fibrinolytic enzyme, plasmin, demonstrates significant binding activity to the group A streptococcus.
authors.affiliation: Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville 32610.
authors.forename: L E
authors.initials: LE
authors.lastname: DesJardin
authors.forename: M D
authors.initials: MD
authors.lastname: Boyle
authors.forename: R
authors.initials: R
authors.lastname: Lottenberg
mesh_terms: D000818:Animals; D004792:Enzyme Precursors / Q000378:metabolism; D005341:Fibrinolysin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D005810:Multigene Family; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding; D012697:Serine Endopeptidases / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000378:metabolism*
chemical_list: D004792:Enzyme Precursors; D010446:Peptide Fragments; D012697:Serine Endopeptidases; D005341:Fibrinolysin