title: Ergometrine and 5-hydroxytryptamine binding sites in rat brain and myometrium.
abstract: Functional studies suggest that ergometrine is a partial agonist involving 5-hydroxytryptamine (5-HT) receptors in rat uterus. Ergometrine displaced [3H]5-HT from specific binding sites in rat brain, but did not displace [3H]5-HT at functionally important concentrations in rat myometrium. These binding studies indicate that the agonist and antagonist actions of ergometrine in rat uterus arise from its initial interaction with binding sites other than those for 5-HT.
authors.affiliation: Department of Physiological Sciences, Medical School, Manchester University, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hollingsworth
authors.forename: M J
authors.initials: MJ
authors.lastname: Dascombe
authors.forename: D
authors.initials: D
authors.lastname: Price
authors.forename: L
authors.initials: L
authors.lastname: Acton
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004874:Ergonovine / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D004874:Ergonovine