Platelet adrenoceptors and prostaglandin responses in depressed patients.
Platelet alpha 2-adrenergic receptor binding and prostaglandin responsivity were measured in depressed patients. Depressed patients had significantly higher platelet 3H-dihydroergocryptine (3H-DHE) binding values than controls. Depressed patients also showed significantly reduced prostaglandin E1-stimulated cyclic adenosine 3',5'-monophosphate (cAMP) production and significantly decreased % inhibition of cAMP production by norepinephrine. These results support the suggestion that there may be a dissociation between alpha 2-adrenergic receptor binding and responsivity in depression. There were no significant correlations between platelet adrenergic variables and other indices of noradrenergic function. However, there was a significant correlation between 3H-DHE binding values and basal plasma levels of cortisol.
Roy
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National Institute of Mental Health, Bethesda, MD.
Kafka
M S
MS
D000328:Adult; D000527:Alprostadil / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D000242:Cyclic AMP / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D003907:Dexamethasone; D004088:Dihydroergotoxine / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012701:Serotonin / Q000097:blood
D011941:Receptors, Adrenergic; D004088:Dihydroergotoxine; D012701:Serotonin; D003907:Dexamethasone; D000242:Cyclic AMP; D000527:Alprostadil; D006854:Hydrocortisone; D009638:Norepinephrine