[The antibody-producing cell count of rats exposed to polymeric 239Pu].
In experiments with Wistar rats a study was made of the content of antibody-forming cells (AFC) in the spleen at remote times (3 to 12 months) after intravenous injection of 239Pu(IV) in doses of 166, 55, and 18 kBq/kg body mass. The doses absorbed in the central and peripheral immunity organs were defined. Pronounced spleen hypoplasia and profound inhibition of humoral immunity were displayed 1 year after the injection of a small amount of the radionuclide. AFC deficiency in animals was amounted to 11-32 per cent throughout the entire period of observation.
Kirillova
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Sokhranich
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D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D007114:Immunization; D008297:Male; D009566:Nitrates / Q000494:pharmacology; D017942:Nitric Acid; D011005:Plutonium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D013997:Time Factors
D009566:Nitrates; C015459:plutonium nitrate; D017942:Nitric Acid; D011005:Plutonium
Soderzhanie antiteloobrazuiushchikh kletok u krys pri deĭstvii polimernogo 239Pu.