[The content of cyclic nucleotides in an organ culture of normal and atherosclerosis-affected human aorta].
Cyclic AMP and cyclic GMP content was measured in intima media of unaffected and atherosclerotic areas of human aorta in a short-term organ culture. It was demonstrated that during short-term cultivation the content of both cyclic nucleotides in tissues is constant. The cyclic AMP content in fatty streaks and atherosclerotic plaques is significantly (2 to 7-fold) lower than in unaffected intima. The cyclic GMP level in atherosclerotic lesions is 1.5 to 3-fold higher than in normal. The content of both cyclic nucleotides in the media underlying fatty streaks and atherosclerotic plaques is the same as in the normal tissue. The obtained data indicate serious disorders in the system of cyclic nucleotides during atherosclerosis.
Tertov
V V
VV
Tabagari
S I
SI
Orekhov
A N
AN
D000328:Adult; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D009924:Organ Culture Techniques
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
Soderzhanie tsiklicheskikh nukleotidov v organnoĭ kul'ture normal'noĭ i porazhennoĭ aterosklerozom aorty cheloveka.