title: The effect of varying extents of Fluosol-DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat.
abstract: Phenytoin kinetics were determined in rats in which the blood was moderately haemodiluted with 20 or 40 mL kg-1 of Fluosol-DA or normal saline. Rats received one of three intravenous phenytoin doses (10, 40, 50 mg kg-1) 0.5, 24, 48, or 72 h after haemodilution and were compared with non-exchanged controls. Haemodilution with either 20 or 40 mL kg-1 of Fluosol or saline had no influence on the dose-dependent kinetics of phenytoin. Haemodilution with 40 mL kg-1 of Fluosol decreased the half-life of phenytoin's major metabolite, HPPH, after a 50 mg kg-1 dose. Neither Fluosol nor saline haemodilution affected the normal delay in biliary cycling of HPPH.
authors.affiliation: Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
authors.forename: R P
authors.initials: RP
authors.lastname: Shrewsbury
authors.forename: S R
authors.initials: SR
authors.lastname: Oliver
authors.forename: L M
authors.initials: LM
authors.lastname: Lewis
authors.forename: W T
authors.initials: WT
authors.lastname: Anderson
authors.forename: L G
authors.initials: LG
authors.lastname: White
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000494:pharmacology; D005466:Fluorocarbons / Q000494:pharmacology*; D006207:Half-Life; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives; D010672:Phenytoin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats
chemical_list: D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C001419:hydroxyphenytoin; D010672:Phenytoin; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination