Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10.
The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10.
Schonk
D M
DM
Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.
Kuijpers
H J
HJ
van Drunen
E
E
van Dalen
C H
CH
Geurts van Kessel
A H
AH
Verheijen
R
R
Ramaekers
F C
FC
D000818:Animals; D000911:Antibodies, Monoclonal; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D015870:Gene Expression; D006801:Humans; D006822:Hybrid Cells; D015151:Immunoblotting; D009687:Nuclear Proteins / Q000235:genetics*; D018809:Proliferating Cell Nuclear Antigen
D000911:Antibodies, Monoclonal; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen