Start and end of the effects of terfenadine and astemizole on histamine-induced wheals in human skin.
A study was made of effects of two antihistamines, terfenadine (60 mg twice daily) and astemizole (10 mg once daily) on wheals induced by histamine dihydrochloride (10 mg/ml) in the prick test on the upper back of 15 healthy students. The suppressive effects of terfenadine on the histamine wheal appeared earlier (2 h), and disappeared earlier (within 1 day) than those of astemizole (3 days and 28 days, respectively). No difference between the maximal effects of the two drugs was seen.
Työlahti
H
H
Department of Dermatology, University of Oulu, Finland.
Lahti
A
A
D000328:Adult; D016589:Astemizole; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D016593:Terfenadine; D013997:Time Factors
D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D016589:Astemizole; D006632:Histamine