title: [Regulation of the immune response using leukotrienes].
abstract: Leukotrienes are derived from lipoxygenation in position 5 of arachidonic acid. They have numerous biological activities, mainly in inflammatory processes. During the last few years, however, it has become quite evident that they also possess a potential for immunoregulation. In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus-infected or tumor target cells. These findings suggest that LTB4 can play an important role in the interaction between inflammatory and immune phenomena.
authors.forename: M
authors.initials: M
authors.lastname: Rola-Pleszczynski
mesh_terms: D006801:Humans; D007111:Immunity, Cellular; D007975:Leukotriene B4 / Q000502:physiology; D015289:Leukotrienes / Q000502:physiology*; D008222:Lymphokines / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015289:Leukotrienes; D008222:Lymphokines; D007975:Leukotriene B4
vernacular_title: Régulation de la réponse immune par les leucotriènes.