title: An international collaborative study of an anti-infectious bursal disease virus reference serum.
abstract: Fourteen laboratories participated in a collaborative study of a freeze-dried preparation of anti-infectious bursal disease virus serum to assess the suitability of the serum as a standard for use in the infectious bursal disease virus neutralization test. Ten laboratories carried out micro-virus neutralization tests and six carried out plaque reduction tests, two laboratories carrying out both tests. When titres were expressed as a proportion of that obtained for a reference preparation there was a marked reduction in variation between results from different laboratories. The use of a reference preparation was therefore of value when comparing results from different laboratories. It is proposed that the reference preparation used in this study be used as a standard to facilitate the comparison of results from different laboratories. The proposed standard contains by definition 10,000 UK units.
authors.affiliation: Central Veterinary Laboratory, Weybridge, Surrey, England.
authors.forename: N E
authors.initials: NE
authors.lastname: Reed
authors.forename: D H
authors.initials: DH
authors.lastname: Thornton
authors.forename: C N
authors.initials: CN
authors.lastname: Hebert
authors.forename: J C
authors.initials: JC
authors.lastname: Muskett
authors.forename: G W
authors.initials: GW
authors.lastname: Wood
mesh_terms: D000818:Animals; D002645:Chickens; D007106:Immune Sera / Q000592:standards*; D007243:Infectious bursal disease virus / Q000276:immunology*; D007391:International Cooperation; D009500:Neutralization Tests; D012015:Reference Standards; D012087:Reoviridae / Q000276:immunology*
chemical_list: D007106:Immune Sera