Thy-1+ dendritic epidermal cells undergo mitosis in vivo.
Recently, morphologic evidence that epidermal Langerhans cells (ELC) undergo a mitotic cycle in normal mouse ear skin has been presented. In the present study, using immunohistochemical staining, we examined the mitotic activity of Thy-1-positive dendritic epidermal cells (Thy-1+DEC) in the normal murine epidermis. A small number of Thy-1+DEC showed round, cleaved, paired, and paired dendritic morphologies, which are identical to those occurring during ELC mitosis. We conclude that normal Thy-1+DEC undergo mitosis within the epidermis to maintain their population in the murine epidermis.
Miyauchi
S
S
Department of Dermatology and Syphilology, Wayne State University School of Medicine, Detroit, MI 48201.
Hashimoto
K
K
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure; D000078404:Epidermal Cells; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008938:Mitosis; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D018800:Thy-1 Antigens