Effect of radioprotective agents on X-ray cataracts.
The effect of some protective agents on cataract development is briefly reviewed and new evidence is presented on the efficacy of a phosphorothioate compound (Amifostine) in inhibiting the development of X-ray-induced cataract. Morphological studies showed that at the end of 4 months, lenses from X-irradiated rats which had not received any drugs showed liquefaction in the equatorial region and at the posterior pole, as well as a marked swelling of the fibers in the anterior cortex. Animals which received 1.16g/kg of WR77913 showed considerable protection against the development of radiation induced cataracts with morphological changes in the lens being less severe than in animals receiving no drugs. When animals were treated with 0.5g/kg of Amifostine (WR2721) the lenses showed much greater protection against cataract development than with WR77913. Amifostine appears to be more effective than WR77913 in inhibiting X-ray-induced cataract development.
Reddy
V N
VN
Eye Research Institute, Oakland University, Rochester, MI 48309-4401.
Ikebe
H
H
Giblin
F J
FJ
Clark
J I
JI
Livesey
J C
JC
D004999:Amifostine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003545:Cysteine / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology; D007908:Lens, Crystalline / Q000187:drug effects / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; C035284:WR 77913; D003545:Cysteine; D004999:Amifostine; D005690:Galactose