Condylomatous lesion (HPV infection) of uterine cervix. A clinical, colposcopic, cyto, histomorphological and immunohistochemical study.
43, patients, subjected to cervical cytology, colposcopy and colposcopic directed biopsy, were found to have lesions suggestive of human Papillomavirus (HPV) infection by one or more parameters. Immunohistochemical staining for HPV antigen yielded positive results in 23 (53.5 p. cent) cases. Amongst 30 cases with HPV lesions both in cytology and histopathology, 19 (63.3 p. cent) were positive for the HPV antigen. This was significantly higher as compared to the groups where HPV lesion was observed in cytology or histology alone (p = 0.05). The rate of positivity was the highest (81.3 p. cent) in a group of 16 patients having low grade dysplasia (mild to moderate) and both cytology and histologic evidence of koilocytotic changes. Presence or absence of HPV lesion by colposcopic examination in these 43 cases did not make any significant difference in rate of antigen positivity.
Luthra
U K
UK
Division of Cytopathology, Maulana Azad Medical College Campus, New-Delhi, India.
Bhatnagar
P
P
Das
D K
DK
Sharma
B K
BK
Kashyap
V
V
Khan
I U
IU
Singh
V
V
Murthy
N S
NS
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001706:Biopsy; D003127:Colposcopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D027383:Papillomaviridae / Q000276:immunology*; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology*
D000914:Antibodies, Viral