Cytogenetic analysis of Wilms' tumor: evidence of a multistep process.
We report the cytogenetic findings observed in the cancer cells of a Wilms' tumor in a 11-month-old girl without the phenotype of the WAGR. Two populations were identified: one had a 46,XX,del(11)(p11p13) karyotype and the other had a translocation involving the deleted chromosome 11 and chromosome 12, t(11;12)(p11;q13). This result strongly suggests that the deletion of 11p was the initiating event to the tumor and that the translocation has been instrumental in promoting its development.
Vekemans
M
M
Department of Pediatric Pathology, McGill University, Montreal, Chicoutimi, Canada.
De Braekeleer
M
M
de Chadarevian
J P
JP
D002869:Chromosome Aberrations / Q000473:pathology*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007223:Infant; D014178:Translocation, Genetic; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology