title: Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice.
abstract: The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.
authors.affiliation: Department of Biochemistry, Sapporo Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
authors.forename: R
authors.initials: R
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Yasumura
authors.forename: T
authors.initials: T
authors.lastname: Akino
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000652:urine; D000818:Animals; D003605:D-Amino-Acid Oxidase / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains
chemical_list: D000596:Amino Acids; D003605:D-Amino-Acid Oxidase