title: Neuroendocrine effects of ovine corticotropin-releasing hormone in panic disorder patients.
abstract: A number of neuroendocrine abnormalities have been reported in panic disorder patients: the most extensively studied being disturbances of hypothalamic-pituitary-adrenal function (Curtis et al. 1982; Leiberman et al. 1983; Uhde et al. 1988). The recent sequencing and synthesis of corticotropin-releasing hormone now allows direct testing of pituitary responsivity to this neuropeptide in affective and panic disorder patients (Holsboer et al. 1984; Gold et al. 1986; Roy-Byrne et al. 1986; Holsboer et al. 1987; Risch et al. 1988). We report the effects of intravenously administered ovine corticotropin-releasing hormone (0.03 micrograms/kg) on plasma concentrations of adrenocorticotropin hormone (ACTH) and cortisol in a small group of panic disorder patients and age- and sex-matched normal controls.
authors.affiliation: Clinical Neuroscience Branch, NIMH, Bethesda, MD 20892.
authors.forename: M H
authors.initials: MH
authors.lastname: Rapaport
authors.forename: S C
authors.initials: SC
authors.lastname: Risch
authors.forename: S
authors.initials: S
authors.lastname: Golshan
authors.forename: J C
authors.initials: JC
authors.lastname: Gillin
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D003346:Corticotropin-Releasing Hormone; D005239:Fear / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007262:Infusions, Intravenous; D010200:Panic / Q000502:physiology*; D011863:Radioimmunoassay
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone