Intermittent leukapheresis: an adjunct to low-dose chemotherapy for Sézary syndrome.
Eleven patients with Sézary syndrome were treated with intermittent leukapheresis in addition to low-dose chlorambucil and prednisone. The results were as good as or better than those with chemotherapy alone. We believe the combined program with continuous leukapheresis to be optimal therapy but note that intermittent treatment offers some benefit for patients.
McEvoy
M T
MT
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Zelickson
B D
BD
Pineda
A A
AA
Winkelmann
R K
RK
D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007937:Leukapheresis; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D012751:Sezary Syndrome / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*
D002699:Chlorambucil; D011241:Prednisone