[The effect of the stimulation of opioid receptors on lymphocyte functional activity in vivo].
With the aid of lymphocytes' spontaneous adhesion test and the reaction of blast transformation with phytohemagglutinin (PHA) the influence of met-enkephaline upon the functional activity of lymphocytes of healthy donors was studied in vitro. It was shown, that met-enkephaline stimulate lymphocyte spontaneous adhesion and the lymphocyte PHA-induced proliferative activity. The stimulating effects of met-enkephalin revealed in vitro were blocked by the opioid receptor blocker naloxone.
Kharkevich
D D
DD
Kadagidze
Z G
ZG
D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004744:Enkephalin, Methionine / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects*; D013268:Stimulation, Chemical
D010835:Phytohemagglutinins; D011957:Receptors, Opioid; D009270:Naloxone; D004744:Enkephalin, Methionine
Vliianie stimuliatsii opioidnykh retseptorov na funktsional'nuiu aktivnost' limfotsitov in vivo.