title: Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferentated male rats.
abstract: The present study was designed to elucidate the site of action of interleukin 1 (IL-1) modulation of the hypothalamic-hypophyseal-adrenal (HHA) axis. An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS). In rats with complete mediobasal hypothalamic deafferentation, the HHA response to IL-1 was inhibited. An intracerebroventricular injection of rIL-1 (2 U/rat) caused a marked increase in serum ACTH and CS. These results suggest that IL-1 activates the HHA axis by a direct effect upon the brain, and that intact neural connections between the mediobasal hypothalamus and extrahypothalamic brain regions are essential for IL-1-induced HHA responses.
authors.affiliation: Department of Neurology, Hadassah-Hebrew University Hospital, Jerusalem, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Ovadia
authors.forename: O
authors.initials: O
authors.lastname: Abramsky
authors.forename: V
authors.initials: V
authors.lastname: Barak
authors.forename: N
authors.initials: N
authors.lastname: Conforti
authors.forename: D
authors.initials: D
authors.lastname: Saphier
authors.forename: J
authors.initials: J
authors.lastname: Weidenfeld
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000502:physiology; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D011994:Recombinant Proteins; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone