Nail-changes induced by penicillamine.
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described. After cessation of treatment there was a gradual resolution with regain of normal nails after 7 months. Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes. The fingernails were more affected than the toenails and clinically the changes consisted of absence of lunulae, longitudinal ridging, transverse or longitudinal defects of the nailplate and a tendency of onychoschizia.
Bjellerup
M
M
Department of Dermatology, University of Lund, General Hospital, Malmö, Sweden.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006801:Humans; D009260:Nail Diseases / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence
D010396:Penicillamine