title: Chronic diazepam treatment induces an increase in peripheral benzodiazepine binding sites.
abstract: The effect of chronic (21 days) diazepam treatment (0.5 mg/kg, intraperitoneally) on [3H]PK 11195 binding to the heart and cerebral cortex was studied. A significant increase in the density of peripheral benzodiazepine binding sites in the heart (18%) and cerebral cortex (19%) was observed. Following five days of withdrawal, the maximal binding capacity of these sites returned to normal control values. No alteration in the equilibrium dissociation constant was observed during the treatment and withdrawal period.
authors.affiliation: Hasharon Hospital, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Weizman
authors.forename: M
authors.initials: M
authors.lastname: Gavish
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002850:Chromatography, Gel; D003975:Diazepam / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007546:Isoquinolines; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007546:Isoquinolines; D011963:Receptors, GABA-A; D003975:Diazepam; C037850:PK 11195