Intermittent neuroleptic treatment induces long-lasting abnormal mouthing in the rat.
Rats were treated either discontinuously or continuously with haloperidol. Only discontinuous treatment caused a long-lasting abnormal rise in the number of mouth movements. After termination of medication the animals were kindled electrically in the nucleus amygdala. The results suggest cross-sensitivity between discontinuous neuroleptic treatment and amygdala kindling. Our results are consistent with the hypothesis of a kindling-like sensitization to the dyskinetic-inducing side-effects of neuroleptic drugs following intermittent antidopaminergic treatment.
Glenthøj
B
B
Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark.
Hemmingsen
R
R
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D014150:Antipsychotic Agents; D006220:Haloperidol