title: Is a persistent adenovirus infection involved in coeliac disease?
abstract: Recent evidence has implicated adenovirus 12 in the aetiology of coeliac disease so that persistent infection by this virus must be considered. We have undertaken a search for adenovirus DNA in duodenal biopsy samples from a total of 26 coeliac and non-coeliac patients. We could find no evidence of persistent virus DNA by Southern blot techniques even under conditions which approach a sensitivity of one copy of virus genome per cell, and use either adenovirus 12 or 41 DNA.
authors.affiliation: Department of Virology, University of Newcastle-upon-Tyne.
authors.forename: M J
authors.initials: MJ
authors.lastname: Carter
authors.forename: M M
authors.initials: MM
authors.lastname: Willcocks
authors.forename: H C
authors.initials: HC
authors.lastname: Mitchison
authors.forename: C O
authors.initials: CO
authors.lastname: Record
authors.forename: C R
authors.initials: CR
authors.lastname: Madeley
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications*; D000258:Adenovirus Infections, Human / Q000150:complications*; D000260:Adenoviruses, Human / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D015139:Blotting, Southern; D002446:Celiac Disease / Q000209:etiology*; D004279:DNA, Viral / Q000032:analysis; D004386:Duodenum / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004279:DNA, Viral