In vitro activity of SK&F 104662, a new glycopeptide antibiotic.
The in vitro activity of SK&F 104662, a new glycopeptide antibiotic, against gram-positive bacteria was evaluated. Activity was comparable to those of teicoplanin and vancomycin against most organisms. SK&F 104662 inhibited diphtheroids at concentrations of less than or equal to 0.5 microgram/ml. Addition of human serum to the test medium lowered the inhibitory activity of this glycopeptide against some organisms by as much as eightfold.
Yao
J D
JD
Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts.
Eliopoulos
G M
GM
Moellering
R C
RC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D017576:Daptomycin; D013293:Enterococcus faecalis / Q000187:drug effects*; D006020:Glycopeptides / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010455:Peptides; C059911:SK&F 104662; D002981:Clindamycin; D017334:Teicoplanin; D014640:Vancomycin; D017576:Daptomycin