Paired stimulation and functional change of the sural nerve during beta blocker therapy.
29 patients were examined during a therapy with beta blockers. The medication was applied over 12 weeks, 16 patients received propranolol 120 mg/day, 13 patients metoprolol 200 mg/day. Two patients showed side-effects. Neurophysiological examinations, i.e. sural nerve conduction velocity and paired stimulation of the sural nerve, revealed a slight decrease of nerve conduction velocity and a significant increase of the latency prolongation of the second nerve action potential when the medication was finished. These functional changes in the sural nerve may result from the interaction of metoprolol and propranolol with beta-receptors of the peripheral nerve.
Husstedt
I W
IW
Department of Neurology, University of Münster.
Grotemeyer
K H
KH
Schlake
H P
HP
Brune
G
G
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D009431:Neural Conduction; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D011930:Reaction Time / Q000502:physiology; D013127:Spinal Nerves / Q000503:physiopathology*; D013497:Sural Nerve / Q000187:drug effects / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D008790:Metoprolol