[The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction].
Distinct increase and then decrease in content of cyclic nucleotides was observed in dog myocardium ventricles and auricles within early periods of heart infarction (10 min-4 hrs). Within a day after ligation of artery the ratio cAMP/cGMP was considerably decreased as a result of activation of guanylate cyclase and cAMP-phosphodiesterase as well as due to a decrease in activity of adenylate cyclase. Acute ischemia of small area of the heart left ventricle caused impairment of cyclic nucleotide metabolism in all the heart muscle.
Frolova
N Iu
NIu
Printsev
M D
MD
Tret'iakov
A V
AV
Kozhetiakin
L A
LA
Korovkin
B F
BF
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004285:Dogs; D004789:Enzyme Activation; D005260:Female; D006162:Guanylate Cyclase / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis
D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D006162:Guanylate Cyclase; D006152:Cyclic GMP
Issledovanie sistem tsiklicheskikh nukleotidov razlichnykh otdelov miokarda sobak pri éksperimental'nom infarkte.