title: S-methylation in motorneuron disease and Parkinson's disease.
abstract: Thiolmethyltransferase activity has been measured in newly diagnosed, untreated patients with idiopathic Parkinson's disease and motorneuron disease, and in normal volunteers. In Parkinsonian patients, mean thiolmethyltransferase activity was low (300 U/mg protein [SD 96]) compared with that in controls (947 [409]), whereas activity was high in patients with motorneuron disease (2077 [825]).
authors.affiliation: Department of Biochemistry, University of Birmingham.
authors.forename: R H
authors.initials: RH
authors.lastname: Waring
authors.forename: G B
authors.initials: GB
authors.lastname: Steventon
authors.forename: S G
authors.initials: SG
authors.lastname: Sturman
authors.forename: M T
authors.initials: MT
authors.lastname: Heafield
authors.forename: M C
authors.initials: MC
authors.lastname: Smith
authors.forename: A C
authors.initials: AC
authors.lastname: Williams
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000097:blood*; D008875:Middle Aged; D009046:Motor Neurons / Q000201:enzymology*; D009468:Neuromuscular Diseases / Q000097:blood / Q000201:enzymology*; D010300:Parkinson Disease / Q000097:blood / Q000201:enzymology*
chemical_list: D008780:Methyltransferases; C022742:thiol S-methyltransferase