Hormonal regulation of collagen gene expression in osteoblastic cell-overview and new findings.
Type I collagen synthesis in osteoblasts is regulated by a variety of systemic hormones, growth factors and locally produced factors. With the use of cDNA probes and hybridization analysis, it appears that many of these agents alter collagen synthesis by a pretranslational mechanism.
Kream
B
B
Department of Medicine, University of Connecticut Health Center, Farmington.
Harrison
J
J
Bailey
R
R
Petersen
D
D
Rowe
D
D
Lichtler
A
A
D000818:Animals; D002478:Cells, Cultured; D002762:Cholecalciferol / Q000494:pharmacology / Q000502:physiology; D003094:Collagen / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology / Q000502:physiology; D010006:Osteoblasts / Q000378:metabolism* / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D012886:Skull / Q000166:cytology
D007328:Insulin; D010281:Parathyroid Hormone; D002762:Cholecalciferol; D007334:Insulin-Like Growth Factor I; D003094:Collagen