[Hepatotoxicity induced by cyanamide. A review of the anatomicopathological changes apropos a case].
A case of toxic liver disease induced by cyanamide in a patient in treatment with this drug during 18 months, is presented. We reviewed the different liver cell alterations produced by a long-term treatment with cyanamide, which produces fibrosis and portal inflammation, as well as polished cells with different characteristic features. These alterations forced the establishing of close controls of patients in treatment with this type of anti-alcoholism drug, as well as the reduction of the duration of therapy, this questioning the efficacy of the treatment of chronic alcoholism with this aversive drug.
Román Llorente
F J
FJ
Iglesias García
E
E
Fojón Polanco
S
S
Mariño Callejo
A
A
Pia Iglesias
G
G
Gordo Fraile
P
P
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D001706:Biopsy; D003484:Cyanamide / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male
D003484:Cyanamide
Hepatotoxicidad inducida por cianamida. Revisión de las alteraciones anatomopatológicas a propósito de un caso.