The necessity of human trials of putative therapies for Alzheimer's disease.
The absence of a suitable animal model for Alzheimer's disease leaves therapeutic trials in human subjects as a necessity. Reasonable criteria can be formulated for deciding which therapies should be tested. Scientific rationale and likelihood of success should be major considerations. Novel approaches of delivering drugs to the central nervous system should not be discouraged so long as complication rates can be shown to be low.
Knopman
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Department of Neurology, University of Minnesota Hospitals, Minneapolis 55455.
D000544:Alzheimer Disease / Q000188:drug therapy*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D007260:Infusion Pumps
D001626:Bethanechol Compounds; D018723:Bethanechol