title: Differing effect of agonist and antagonist muscle relaxants on cat jaw muscles.
abstract: Mouth closure and an increased resistance to mouth opening follow succinylcholine administration in humans. To elucidate the effects of succinylcholine on masticatory muscle function, mouth opening in the cat, produced by a constant test force, was measured during steady state halothane anesthesia. After baseline measurements, either succinylcholine (0.3 mg.kg-1 of body weight) or vecuronium (0.1 mg.kg-1 of body weight) was infused intravenously, and mouth opening measurements were repeated for up to 30 min. Concomitantly, muscle relaxant effect was quantified by measurement of the neurally-evoked tibialis anterior muscle response. All animals given succinylcholine displayed active jaw closure, which was followed by an increased resistance to mouth opening. This increased resistance was present after cessation of fasciculations and during complete twitch suppression. It lasted beyond the time at which the limb muscle twitch had fully recovered. Vecuronium administration was associated with a decreased resistance to mouth opening without a closing action. The initial jaw closure and the subsequently increased resistance to mouth opening after succinylcholine administration during halothane anesthesia in the cat are comparable with mouth opening changes after succinylcholine administration during inhalation anesthesia in humans. The cat may serve as an animal model for study of the mechanisms involved in responses of jaw muscles to succinylcholine with use of techniques inappropriate in humans.
authors.affiliation: Department of Anesthesiology, University of Michigan, Ann Arbor 48109-0800.
authors.forename: A F
authors.initials: AF
authors.lastname: Van der Spek
authors.forename: P I
authors.initials: PI
authors.lastname: Reynolds
authors.forename: J A
authors.initials: JA
authors.lastname: Ashton-Miller
authors.forename: C S
authors.initials: CS
authors.lastname: Stohler
authors.forename: M A
authors.initials: MA
authors.lastname: Schork
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D008410:Masticatory Muscles / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D013390:Succinylcholine / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D014673:Vecuronium Bromide; D013390:Succinylcholine