[The relation of changes in the surface markers and the induction of thymocyte functional activity under the action of humoral thymic factors].
Mouse thymocytes were fractionated on PNA+- and PNA-cells. The PNA+-fraction was treated by tactivin--a preparation of thymic hormones. The treatment resulted in the loss of PNA-receptors from the surface of 10-12% of PNA+-cells. The treated suspension was again fractionated by the same method. PNA-thymocytes derived from both the first and the second procedure of fractionation expressed less Thy-1.2 antigen and SBA-receptors than PNA+-cells. Primary and induced PNA-thymocytes were able to produce IL-2 after mitogen stimulation. The data can be interpreted as an evidence of the ability of thymic hormones to induce not only a phenotypical but also a functional maturation of PNA+-thymocytes and of linkage of all the observed signs of maturation.
Iarilin
A A
AA
Nikonova
M F
MF
Lutsik
M D
MD
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000954:Antigens, Surface; D010367:Arachis; D002458:Cell Fractionation; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011975:Receptors, Mitogen; D013025:Glycine max; D013499:Surface Properties; D018800:Thy-1 Antigens; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000502:physiology
D000276:Adjuvants, Immunologic; D000954:Antigens, Surface; D007376:Interleukin-2; D008934:Mitogens; D010455:Peptides; D011975:Receptors, Mitogen; D018800:Thy-1 Antigens; D013949:Thymus Extracts; C038223:peanut agglutinin receptor; C046772:soybean lectin receptor; C036191:T-activin
Vzaimosviaz' izmeneniĭ poverkhnostnykh markerov i induktsii funktsional'noĭ aktivnosti timotsitov pri deĭstvii gumoral'nykh faktorov timusa.