[Comparative efficacy of tiniba and fasigyn in treating primary and persisting Giardia infections].
Efficacity of tiniba (tinidasole, Kadila, India) and of fasigyn (Polfa, Poland) dosed 300 mg daily for 7 days was 87.5 and 85.2% (P greater than 0.05) immediately after treatment and 45.5 and 50.0% (P greater than 0.05) 4-8 months later, respectively. The lack of parasitocidal effect was established in 4 out of 27 tiniba-treated patients and in 3 out of 24 fasigyn treated ones. Direct correlation between the efficacy of persisting giardia infection chemotherapy and the cAMP phosphodiesterase activity in blood lymphocytes was found previously. Authors established an indirect correlation between the former and hydrochloric acid secretion by the bowel.
Ozeretskovskaia
N N
NN
Kulinich
G V
GV
Firsova
R A
RA
Panteleeva
E A
EA
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000328:Adult; D005260:Female; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014011:Tinidazole / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Sravnitel'naia éffektivnost' tiniba i fasizhina pri lechenii bol'nykh s liamblioznoĭ infektsieì obychnogo i upornogo techeniia.