Decline of hemopoietic stem cells during serial transplants in lethally irradiated recipients.
Stochastic and field models of hemopoietic stem cell renewal are tested for quantitative predictions regarding limited survival of mouse stem cells during serial transplant from donors into lethally irradiated recipients. Besides circumventing the limitations of stochastic theories, the field model is found to be congruent with experimental data.
Matioli
G T
GT
University of Southern California School of Medicine, Los Angeles, 90033.
D000818:Animals; D002454:Cell Differentiation / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D006085:Graft Survival / Q000528:radiation effects*; D018380:Hematopoietic Stem Cell Transplantation; D051379:Mice; D013269:Stochastic Processes; D014916:Whole-Body Irradiation