[Neurotoxicity with cytostatic therapy: a review].
Neurotoxicity is of increasing importance in the treatment of cancer patients. Since the dose-limiting hematological toxicity of most cytostatic drugs can now be overcome by modern supportive therapy, high-dose chemotherapy with curative intent can be used more often. Non-hematological toxicities such as neurotoxicity will therefore become dose-limiting with greater frequency, and to avoid disabling neurological side effects of chemotherapy the drug-induced neurological disturbances must be recognized before irreversible damage has occurred. The neurological side effects of the cytostatic drugs are reviewed.
Cerny
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T
Institut für Medizinische Onkologie, Universität Bern, Inselspital.
Meier
C
C
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced; D002493:Central Nervous System Diseases / Q000139:chemically induced; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D013118:Spinal Cord Diseases / Q000139:chemically induced
D000970:Antineoplastic Agents
Neurotoxizität bei Zytostatikatherapie: eine Ubersicht.