Unusual development of polyoma virus in the brains of two patients with the acquired immune deficiency syndrome (AIDS).
Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of progressive multifocal leucoencephalopathy (PML) in both cases. Electron microscopy demonstrated round and rod shaped particles of papovavirus in the nuclei and cytoplasm of oligodendrocytes and in processes of astrocytes where abnormal and florid modes of viral replication were seen. Additional features observed were viral particles suggestive of an enterovirus in Case 1 and, in both specimens, massive membrane proliferation within both nuclei and cytoplasm of infected cells together with the presence of tubuloreticular structures (TRS) in the cytoplasm of endothelial cells. At post-mortem, the brain of patient 2 showed PML and HIV encephalitis. The presence of HIV was confirmed by immunohistochemical methods. We suggest that in AIDS patients the abnormality of the immune system induced by HIV causes abnormal replication patterns of papovavirus in the brain. In addition, these cases confirm the frequent occurrence in AIDS patients of TRS, now considered to be a marker for HIV.
Scaravilli
F
F
Department of Neuropathology, National Hospital, London.
Ellis
D S
DS
Tovey
G
G
Harcourt-Webster
J N
JN
Guiloff
R J
RJ
Sinclair
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000473:pathology; D011120:Polyomavirus; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology