The interaction of temelastine with cytochrome P450 mixed-function oxidase enzymes in vivo and in vitro.
Chenery
R J
RJ
Smith Kline & French Research Limited, The Frythe, Welwyn Garden City, Herts, U.K.
Cox
P J
PJ
Rath
L C
LC
Standring
P
P
Oldham
H G
HG
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D005260:Female; D006207:Half-Life; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D065607:Cytochrome P-450 Enzyme Inhibitors; D006634:Histamine H1 Antagonists; D011744:Pyrimidinones; C049054:temelastine; D000983:Antipyrine