Multivisceral intestinal transplantation: surgical pathology.
We report the diagnostic surgical pathology of two children who underwent multivisceral abdominal transplantation and survived for 1 month and 6 months. There is little relevant literature, and diagnostic criteria for the various clinical possibilities are not established; this is made more complicated by the simultaneous occurrence of more than one process. We based our interpretations on conventional histology, augmented with immunohistology, including HLA staining that distinguished graft from host cells in situ. In some instances functional analysis of T cells propagated from the same biopsies was available and was used to corroborate morphological interpretations. A wide spectrum of changes was encountered. Graft-versus-host disease, a prime concern before surgery, was not seen. Rejection was severe in 1 patient, not present in the other, and both had evidence of lymphoproliferative disease, which was related to Epstein-Barr virus. Bacterial translocation through the gut wall was also a feature in both children. This paper documents and illustrates the various diagnostic possibilities.
Jaffe
R
R
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania.
Trager
J D
JD
Zeevi
A
A
Sonmez-Alpan
E
E
Duquesnoy
R
R
Todo
S
S
Rowe
M
M
Starzl
T E
TE
D000956:Antigens, Viral / Q000032:analysis; D036022:Capsid Proteins; D002675:Child, Preschool; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007160:Immunoproliferative Disorders / Q000276:immunology / Q000473:pathology; D007422:Intestines / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D016031:Liver Transplantation / Q000276:immunology / Q000473:pathology*; D016035:Pancreas Transplantation / Q000276:immunology / Q000473:pathology*; D013270:Stomach / Q000276:immunology / Q000473:pathology / Q000637:transplantation*
D000956:Antigens, Viral; D036022:Capsid Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen