Selective expression of des-Arg9-BK sensitive (B1) receptors in vivo and in vitro by angiotensin converting enzyme inhibitors.
LPS (E. Coli), captopril, enalapril, teprotide and BK-infusion induced after 18 h in rabbits an increased hypotensive response to the selective B1-receptor agonist des-Arg9-BK. A similar selective increase in responsiveness and sensitivity of the in vitro aortic strip to des-Arg9-BK taken from pretreated animals was also seen. These results suggest that angiotensin converting enzyme inhibitors may elevate endogenous kinin levels which may contribute towards the inflammatory side-effects seen with this group of drugs.
Whalley
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Department of Physiological Sciences, Medical School University of Manchester, UK.
Nwator
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D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values
D000806:Angiotensin-Converting Enzyme Inhibitors; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; C024626:bradykinin, des-Arg(9)-; D001920:Bradykinin