Low plasma beta-endorphin in post-traumatic stress disorder.
We compared serum cortisol, ACTH and plasma beta-endorphin in 21 Post-Traumatic Stress Disorder patients and 20 controls. Although we found no important disturbance in diurnal rhythms, the PTSD patients had significantly higher A.M. serum cortisols compared with controls. Both A.M. and P.M. plasma beta-endorphins in PTSD patients were significantly lower compared with controls. These data suggest that plasma beta-endorphin may be a marker for PTSD and that chronic endogenous opioid depletion may play a role in the pathogenesis and perpetuation of this disorder.
Hoffman
L
L
Repatriation General Hospital, Hobart, Tasmania.
Burges Watson
P
P
Wilson
G
G
Montgomery
J
J
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002940:Circadian Rhythm; D003130:Combat Disorders / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000097:blood*; D014744:Vietnam; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone