title: Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney.
abstract: The participation of beta 1-adrenoceptor on renin secretion was studied in perfused rat kidney. Administration of propranolol, inhibited the renin release mediated by isoproterenol. Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor.
authors.affiliation: Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Granada, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Haro
authors.forename: F
authors.initials: F
authors.lastname: Vargas
authors.forename: M A
authors.initials: MA
authors.lastname: Castillo
authors.forename: L
authors.initials: L
authors.lastname: García-Torres
authors.forename: D
authors.initials: D
authors.lastname: Acuña
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012083:Renin / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013045:Species Specificity
chemical_list: D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D012083:Renin; D008790:Metoprolol; D007545:Isoproterenol; D011217:Practolol