title: Stimulatory effect of short-chain fatty acids on epithelial cell proliferation of isolated and denervated jejunal segment of the rat.
abstract: Involvement of the mesenteric nerve in the efferent transmission of the trophic effect of short-chain fatty acids was tested in rats. A short segment of jejunum was translocated under the skin with or without its mesenteric connection maintained. A mixture of acetic, propionic, and n-butyric acids (100, 20, and 60 mM, respectively) or 0.9% NaCl (control) was injected into the caecum via an ileostomy twice a day for 14 days. Trophic effects of short-chain fatty acids were observed in jejunal and caecal segments and in the translocated jejunal segments both with and without mesenteric connection. The results suggest that short-chain fatty acids given into the hindgut lumen can indirectly stimulate the epithelial cell proliferation of a distant intestinal segment without luminal continuation to the site of administration, and this trophic effect does not require efferent transmission by nerves in the mesentery. Blood-born mediation is likely.
authors.affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakata
mesh_terms: D000085:Acetates / Q000008:administration & dosage; D000818:Animals; D002087:Butyrates / Q000008:administration & dosage; D002432:Cecum / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D003714:Denervation; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005232:Fatty Acids, Volatile / Q000008:administration & dosage*; D007081:Ileostomy; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D007583:Jejunum / Q000166:cytology / Q000187:drug effects* / Q000637:transplantation; D008297:Male; D011422:Propionates / Q000008:administration & dosage; D051381:Rats; D011916:Rats, Inbred F344; D013153:Splanchnic Nerves / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000085:Acetates; D002087:Butyrates; D005232:Fatty Acids, Volatile; D011422:Propionates