Norwalk virus in Norway: an outbreak of gastroenteritis studied by electron microscopy and radioimmunoassay.
An outbreak of acute gastroenteritis affected approximately half of 40 children staying at a holiday centre in Southern Norway. By direct electron microscopy Norwalk-like viruses were demonstrated in 4/8 available stool specimens. No other pathogens were detected. Antibody against these viruses was demonstrated by immune electron microscopy in all of 7 convalescent phase sera but in none of 11 acute phase sera collected. Radioimmunoassay examination showed a rise in titre of Norwalk virus antibody in 6 available paired sera. This outbreak of Norwalk virus gastroenteritis in Norway was thus documented by a combined use of direct and immune electron microscopy and radioimmunoassay.
Kjeldsberg
E
E
Department of Virology, National Institute of Public Health, Oslo, Norway.
Anestad
G
G
Greenberg
H
H
Orstavik
I
I
Pedersen
R
R
Slettebø
E
E
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008854:Microscopy, Electron; D009663:Norwalk virus / Q000276:immunology* / Q000302:isolation & purification / Q000648:ultrastructure; D009664:Norway / Q000453:epidemiology; D011863:Radioimmunoassay; D014777:Virus Diseases / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology
D000914:Antibodies, Viral