title: Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.
abstract: A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.
authors.affiliation: Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.
authors.forename: S C
authors.initials: SC
authors.lastname: Harris
authors.forename: J E
authors.initials: JE
authors.lastname: Wallace
authors.forename: G
authors.initials: G
authors.lastname: Foulds
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
mesh_terms: D002849:Chromatography, Gas; D015725:Fluconazole; D006801:Humans; D007202:Indicators and Reagents; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D007202:Indicators and Reagents; D014230:Triazoles; D015725:Fluconazole