Testing of methyleneiminodiacetic-catechol and other aromatic chelating agents for decorporation of 238Pu and 241Am in rats.
The removal of 238Pu and 241Am by five chelating agents prepared in China was compared in pilot experiments with removal by Ca-DTPA and LICAM(C). The most promising substance is quinamic acid (a methyliminodiacetic polyquinoline derivative, code name 811 or 703-73), especially in combination with Ca-DTPA. However, the best over-all reduction of both 238Pu and 241Am in all the organs studied was achieved by Ca-DTPA-administered at a ten-fold human equivalent dosage.
Luo
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MC
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, F.R. Germany.
Volf
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D000576:Americium / Q000378:metabolism*; D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage*; D005260:Female; D007546:Isoquinolines / Q000008:administration & dosage*; D004369:Pentetic Acid / Q000008:administration & dosage; D011005:Plutonium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014018:Tissue Distribution
D002614:Chelating Agents; D007546:Isoquinolines; D011005:Plutonium; C034834:LICAM-C; C032945:quinamic acid; D004369:Pentetic Acid; D013095:Spermidine; D000576:Americium