title: Feeding pure docosahexaenoate or arachidonate decreases plasma triacylglycerol secretion in rats.
abstract: Essential fatty acid (EFA)-deficient rats were fed highly purified methyl esters of docosahexaenoate (22:6n-3), arachidonate (20:4n-6), alpha-linolenate (18:3n-3) or oleate (18:1n-9) (100 mg/day, tube fed for 3-10 days), and their plasma triacylglycerol (TG) secretion rates were measured. Secretion rates of TG into plasma were reduced by tube-feeding 22:6n-3, 20:4n-6, 18:3n-3, but not 18:1n-9, to EFA-deficient rats. A significant reduction occurred after feeding 22:6n-3 for only three days. Feeding 22:6n-3 or 18:3n-3 to EFA-deficient rats for three days also reduced the activities of liver lipogenic enzymes and sharply increased the proportions of 22:6n-3 and 20:5n-3 in liver phospholipid fractions. Mechanisms by which these EFA may reduce lipogenesis are discussed.
authors.affiliation: Department of Nutritional Sciences, University of California, Berkeley 94720.
authors.forename: M A
authors.initials: MA
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Tinoco
authors.forename: Y T
authors.initials: YT
authors.lastname: Yang
authors.forename: M I
authors.initials: MI
authors.lastname: Bird
authors.forename: I
authors.initials: I
authors.lastname: Hincenbergs
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008042:Linolenic Acids / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000032:analysis / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood*; D017962:alpha-Linolenic Acid
chemical_list: D001095:Arachidonic Acids; D004041:Dietary Fats; D008042:Linolenic Acids; D010743:Phospholipids; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D008291:Malate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase