Paradoxical response of plasma beta-endorphin to combined administration of TRH and GnRH in adrenal disorders.
The combined intravenous injection of TRH and GnRH elicited paradoxical responses of plasma beta-endorphin in active and successfully treated pituitary dependent Cushing's disease as well as in ectopic ACTH syndrome and in congenital adrenal hyperplasia. No response was observed in Cushing's syndrome due to adrenal tumours. It is concluded that an abnormal response to inappropriate releasing hormones cannot verify the existence of a pituitary corticotrophic microadenoma.
Knappe
G
G
Clinic of Internal Medicine, Humboldt-University (Charité), Berlin/GDR.
Gerl
H
H
Rückert
R I
RI
Rückert
Y
Y
Rohde
W
W
Stahl
F
F
D000236:Adenoma / Q000097:blood* / Q000556:secondary; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000556:secondary; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D001615:beta-Endorphin / Q000097:blood*
D010906:Pituitary Hormone-Releasing Hormones; D013973:Thyrotropin-Releasing Hormone; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone