Enhancement of phenytoin binding to tissues in rats by heat treatment.
Phenytoin binding to heat-treated tissue homogenates has been examined to characterize the phenytoin binding to tissues. The binding to the heat-treated tissue homogenates was enhanced in all tissues studied compared with controls. The heating might produce the changes in conformation of proteins in tissues and then enhance phenytoin binding to tissue homogenates.
Kato
Y
Y
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Japan.
Hirate
J
J
Sakaguchi
K
K
Horikoshi
I
I
D000818:Animals; D006358:Hot Temperature; D008297:Male; D010672:Phenytoin / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D010672:Phenytoin