Putrescine reverses aconitine-induced arrhythmia in rats.
Putrescine, (150-300 mg kg-1 i.v.) injected into anaesthetized rats reversed aconitine-induced arrhythmia and restored sinus rhythm. In the same experimental model, quinidine and lignocaine had a transient therapeutic effect, procainamide was practically ineffective and verapamil worsened the aconitine arrhythmia, causing the death of all treated animals. These data demonstrate that putrescine has an antiarrhythmic effect in an experimental model particularly resistant to usual antiarrhythmic treatments.
Bazzani
C
C
Institute of Pharmacology, University of Modena, Italy.
Genedani
S
S
Tagliavini
S
S
Bertolini
A
A
D000157:Aconitine / Q000037:antagonists & inhibitors*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D007275:Injections, Intravenous; D011700:Putrescine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D011700:Putrescine; D000157:Aconitine