title: Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.
abstract: To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.
authors.affiliation: Department of Neurology, London Hospital, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: C
authors.initials: C
authors.lastname: Kennard
authors.forename: M
authors.initials: M
authors.lastname: Swash
authors.forename: B
authors.initials: B
authors.lastname: Summers
authors.forename: G M
authors.initials: GM
authors.lastname: Yuill
authors.forename: D I
authors.initials: DI
authors.lastname: Shepherd
authors.forename: S
authors.initials: S
authors.lastname: Roche
authors.forename: G D
authors.initials: GD
authors.lastname: Perkin
authors.forename: L A
authors.initials: LA
authors.lastname: Loizou
authors.forename: R
authors.initials: R
authors.lastname: Ferner
mesh_terms: D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000324:Adrenocorticotropic Hormone; D008775:Methylprednisolone