title: [Clinical significance of serum AKP, HSAP, LAP and gamma-GT determination in high-risk pregnancy].
abstract: Serum levels of alkaline phosphatase (AKP), heat stable alkaline phosphatase (HSAP), leucine aminopeptidase (LAP) and gamma-glutamyl transferase(gamma-GT) were determined in 249 blood samples from 202 women with normal or high-risk pregnancy at 30-42 weeks. The results showed that AKP and HSAP increased with the advance of gestational weeks (r = 0.9 259, P less than 0.01), reaching their plateau at 37-38th week. In severe hypertensive pregnant woman, AKP and gamma-GT were significantly elevated, while HSAP remained in consistent low level. A "dissociation phenomenon" between AKP and HSAP was discovered. In cases of prolonged pregnancy, oligohydramnios and IUGR with fetal distress and neonatal asphyxia, both AKP and HSAP were lower than those in normal pregnancies of same gestitional age. Serum level of HSAP might reflect the placental function, while combined with AKP and gamma-GT could also be helpful in assessing the severity of hypertension in pregnancy and in predictive feto-maternal prognosis.
authors.forename: J
authors.initials: J
authors.lastname: Liu
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000097:blood*; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase