Comparison of low-threshold Ca2+ currents in the hippocampal CA1 neurons among the newborn, adult and aged rats.
The electrical and pharmacological properties of the low-threshold Ca2+ current were compared among the newborn, adult and aged rats using the isolated hippocampal CA1 pyramidal neurons. The current-voltage relationship and the time constant of the decay phase of the low-threshold Ca2+ current in adult and aged rats were similar to those in newborn rats. The low-threshold Ca2+ current of adult and aged rats was also sensitive to nicardipine, a dihydropyridine derivative, same as that of newborn rats. We concluded that the nature of low-threshold Ca2+ current in the rat hippocampal CA1 pyramidal neurons is not affected by the aging.
Takahashi
K
K
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Tateishi
N
N
Kaneda
M
M
Akaike
N
N
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004553:Electric Conductivity; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009529:Nicardipine / Q000494:pharmacology; D009532:Nickel / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D015220:Calcium Channels; D009532:Nickel; D009529:Nicardipine