title: Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice.
abstract: Two lines of E alpha d-expressing NOD mice were established by continuously backcrossing [E alpha d B6 transgenic mice x NOD] F1 to parental NOD or directly microinjecting the E alpha d gene into fertilized NOD eggs. Similarly, A beta k-expressing transgenic NOD mice were produced. Subsequent histological examination of pancreatic tissues revealed that autoimmune insulitis was prevented in E alpha d backcross and transgenic mice but not in A beta k transgenic mice.
authors.affiliation: Shionogi Research Laboratory, Shionogi Co. Ltd, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uehira
authors.forename: M
authors.initials: M
authors.lastname: Uno
authors.forename: T
authors.initials: T
authors.lastname: Kürner
authors.forename: H
authors.initials: H
authors.lastname: Kikutani
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Inomoto
authors.forename: T
authors.initials: T
authors.lastname: Uede
authors.forename: J
authors.initials: J
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Nishimoto
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D003433:Crosses, Genetic; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen