[Function of protein myristoylation in cellular regulation and viral proliferation].
Protein myristoylation was first discovered in the catalytic subunit of adenosine 3',5'-cyclic monophosphate-dependent protein kinase. Subsequently, various cellular and viral myristoylated proteins were detected. In each case, the myristoyl moiety was found in an amide linkage with the amino terminal glycine residue of the modified proteins. The biological functions of protein myristoylation of various cellular protein, oncogene product, and viral structural proteins have been studied by many biochemists. Two of the most thoroughly studies myristoylated proteins are the transforming protein of Rous sarcoma virus, pp60v-src, and the proto-oncogene product, pp60c-src. Deletion, modification of the first 14 NH2-terminal amino acid of pp60v-src, or chemical antimyristoylation of the protein with N-myristoyl glycinal diethylacetal does not affect intrinsic tyrosine src-kinase activity, but prevents myristoylation and membrane association, and abolishes the transforming activity of the protein. Protein myristoylations of some viral structural proteins were also studied by many investigators, and X-ray crystallographic studies of poliovirus suggest that myristate moiety may play a central role in capsid assembly. Recently, human immunodeficiency virus, HIV-I, process a myristoylated p17gag protein, which is proteolytically derived from the NH2-terminus of a gag precursor protein, and its myristate moiety may be important for virus assembly. In this review, we detailed recent studies of the protein myristoylation in cellular regulation and virus proliferation.
Shoji
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S
Kubota
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000502:physiology*; D002472:Cell Transformation, Viral; D006678:HIV / Q000502:physiology*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology; D006801:Humans; D019814:Myristic Acid; D009227:Myristic Acids; D010455:Peptides / Q000276:immunology; D011506:Proteins / Q000502:physiology; D000090063:Proto-Oncogene Mas; D014764:Viral Proteins / Q000502:physiology; D014779:Virus Replication
C000715470:MAS1 protein, human; D009227:Myristic Acids; D010455:Peptides; D011506:Proteins; D000090063:Proto-Oncogene Mas; D014764:Viral Proteins; D019814:Myristic Acid