Pharmacokinetics of iotrolan after intravenous injection into healthy volunteers.
In man Iotrolan is distributed in the extravascular space after intravenous injection with a half-life of about 11 minutes, the elimination half-life being about 108 minutes. After intravenous injection 99.2 +/- 1.8% of the dose was found in the urine and 0.5 +/- 0.1% in the feces within 5 days. No metabolization occurred in man and the pharmacokinetic behavior of iotrolan is comparable to that of known nonionic contrast media (e.g., iohexol, iopromide) (7, 9, 13).
Scholz
P
P
Weinmann
H J
HJ
Mützel
W
W
Staks
T
T
D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007275:Injections, Intravenous; D007463:Iodobenzoates / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D014018:Tissue Distribution; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C033300:iotrolan