Effect of histamine H1-receptor antagonist on the regulation of carbohydrate and lipid metabolism in rat liver.
In order to elucidate the role of histamine in the liver, we studied the effect of a histamine H1-receptor antagonist on the carbohydrate and lipid metabolism in the rat liver. The administration of the H1-receptor antagonist decreased significantly the contents of glycogen and malonyl-CoA in the liver. However, it did not affect the levels of serum glucose and free fatty acid. These results suggest that histamine may play a part in the regulation of metabolism of carbohydrates and lipids in the liver.
Koyama
Y
Y
Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan.
Imoto
M
M
Tanaka
M
M
Fukuda
Y
Y
Miyazawa
Y
Y
Nakano
I
I
Ozawa
T
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002744:Chlorpheniramine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008316:Malonyl Coenzyme A / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006634:Histamine H1 Antagonists; D008112:Liver Glycogen; D002744:Chlorpheniramine; D008316:Malonyl Coenzyme A