title: [The role of the substrate structure in the function of Na,K-ATPase].
abstract: The mechanism of Na,K-ATPase function is reviewed. The peculiarities of hydrolysis of various substrates are described. The experimental results testify to the effect of substrate structure on the E2----E1 transition, rate of Na+ transport, K-dependent phosphatase activation and the quaternary structure of Na,K-ATPase. A conclusion is drawn that the proton-acceptor properties of the substrate play a role in the regulation of ion transport by Na,K-ATPase.
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
authors.forename: O D
authors.initials: OD
authors.lastname: Lopina
authors.forename: I A
authors.initials: IA
authors.lastname: Svinukhova
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Rol' struktury substrata v funktsionirovanii Na,K-ATPazy.