title: Coexistence of NMDA and non-NMDA receptors on turtle horizontal cells revealed using isolated retina preparations.
abstract: Effects of glutamate and its agonists on horizontal cells appeared diversely when studied in turtle eyecup preparations. Consistent results were obtained when the isolated retina preparations were used. Not only kainate and quisqualate but also N-methyl-D-aspartate (NMDA) caused a sustained depolarization and light-evoked responses were suppressed for as long as these agonists were superfused. A selective antagonist of NMDA, 2-amino-5-phosphonovalerate (APV), hyperpolarized horizontal cells and reduced their light-evoked responses. These results indicate the coexistence of NMDA and non-NMDA receptors on turtle horizontal cells.
authors.affiliation: Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Miyachi
authors.forename: M
authors.initials: M
authors.lastname: Murakami
mesh_terms: D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000187:drug effects; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D016202:N-Methylaspartate; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000502:physiology*; D014426:Turtles / Q000502:physiology*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D009467:Neuromuscular Depolarizing Agents; D010069:Oxadiazoles; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D016318:Quisqualic Acid; D014633:Valine; D007608:Kainic Acid