title: Treatment of migraine with salmon calcitonin: effects on plasma beta-endorphin, ACTH and cortisol levels.
abstract: In this study we have examined the results of salmon calcitonin treatment on migraine pain. The mechanism by which calcitonin induces analgesia is still not understood. We observed the effect of a 5-day treatment with salmon calcitonin (IM 100 IU/day) on circulating levels of beta-endorphin, ACTH, and cortisol in 20 patients with migraine during the headache-free period. All 3 hormones were increased after the calcitonin administration and the maximum increase was obtained in beta-endorphin levels. There were significant statistical correlations between beta-endorphin, ACTH, and cortisol levels determined before and after calcitonin treatment.
authors.affiliation: Department of Biochemistry and Neurology, University of Erciyes, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ustdal
authors.forename: P
authors.initials: P
authors.lastname: Dogan
authors.forename: A
authors.initials: A
authors.lastname: Soyuer
authors.forename: S
authors.initials: S
authors.lastname: Terzi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000188:drug therapy*; D012016:Reference Values; D012474:Salmon; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D006854:Hydrocortisone