title: The measurement of transmembrane cation transport in vivo in acute manic illness.
abstract: We have used a novel technique to assess the transport of cations across the erythrocyte membrane in vivo in unmedicated patients suffering an acute manic illness. The results show that erythrocyte cation transport via the sodium-pump enzyme Na+,K+-ATPase is increased in manic patients compared with healthy controls.
authors.affiliation: MRC Unit, Radcliffe Infirmary, Oxford.
authors.forename: A J
authors.initials: AJ
authors.lastname: Wood
authors.forename: J K
authors.initials: JK
authors.lastname: Aronson
authors.forename: P J
authors.initials: PJ
authors.lastname: Cowen
authors.forename: D G
authors.initials: DG
authors.lastname: Grahame-Smith
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000201:enzymology*; D002712:Chlorides; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012413:Rubidium / Q000493:pharmacokinetics*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
chemical_list: D002712:Chlorides; D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium; C032710:rubidium chloride; D011188:Potassium