Renal excretion and computed tomography enhancement of iotrolan and iopamidol in dogs.
A comparison of the renal excretion and computed tomography (CT) enhancement of nonionic, monomer and dimer contrast media (CM) (iopamidol and iotrolan) was planned to determine if the latter provides additional and prolonged enhancement in dogs. The excretion studies show almost identical performance of both CM with respect to plasma concentration and renal excretion. However, the lower osmolality of iotrolan permits greater renal concentration in the medulla, papilla, and urine. The potential for this further enhancement of the kidney in CT or urography is marginal.
Benness
G
G
Evill
C
C
Wilcox
J
J
Hassam
R
R
Arozoo
E
E
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007463:Iodobenzoates / Q000493:pharmacokinetics*; D007479:Iopamidol / Q000493:pharmacokinetics*; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000493:pharmacokinetics*; D014567:Urography
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007479:Iopamidol