The interstitial system of the spinal trigeminal tract in the rat: anatomical evidence for morphological and functional heterogeneity.
Utilizing cyto-, myelo-, and chemoarchitecture as well as connectional criteria, the present study reveals the interstitial system of the spinal trigeminal tract (InSy-SVT) in the rat to be composed of five morphologically and functionally distinct components that are distributed within spatially restricted regions of the lateral medulla. The first component is represented by scattered interstitial cells and neuropil, which extend laterally into SVT from the superficial laminae of the medullary dorsal horn (MDH). The second component, the dorsal paramarginal nucleus (PaMd), consists of a small group of marginal (lamina I)-like neurons and neuropil situated within the dorsolateral part of SVT at the rostral pole of MDH. The third component represents a trigeminal extension of the parvocellular reticular formation (V-Rpc) into the ventromedial aspect of SVT at levels extending from rostral MDH to the caudal part of trigeminal nucleus interpolaris (Vi). The fourth component, the paratrigeminal nucleus (PaV), consists of a large accumulation of neurons and neuropil situated within the dorsal part of SVT throughout the caudal half of Vi. The fifth component is the insular trigeminal-cuneatus lateralis nucleus (iV-Cul), which is a discontinuous collection of neurons and neuropil interspersed among fibers of SVT as well as wedged between it and the spinocerebellar tract. Thalamic projection neurons are located in PaMd and V-Rpc, whereas cerebellar projecting neurons are confined to iV-Cul.
Phelan
K D
KD
Department of Anatomy, Michigan State University, East Lansing 48824-1316.
Falls
W M
WM
D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001931:Brain Mapping; D005727:Ganglia, Spinal / Q000033:anatomy & histology*; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology*; D009413:Nerve Fibers, Myelinated / Q000033:anatomy & histology; D009474:Neurons / Q000033:anatomy & histology / Q000145:classification; D009619:Nociceptors / Q000033:anatomy & histology; D051381:Rats; D012154:Reticular Formation / Q000033:anatomy & histology; D009435:Synaptic Transmission; D014276:Trigeminal Nerve / Q000033:anatomy & histology; D014278:Trigeminal Nuclei / Q000033:anatomy & histology; D014279:Trigeminal Nucleus, Spinal / Q000033:anatomy & histology*