title: Determination of microscopic dissociation constants of 3-hydroxy-alpha-(methylamino)methyl-benzenemethanol by a spectral deconvolution method.
abstract: Microscopic dissociation constants of 3-hydroxy-alpha-(methylamino)methyl-benzenemethanol have been calculated from the titration spectrophotomeric data (c = 3.8 x 10(-4) M. Ionic strength = 0.16; buffer system: H3BO3/KOH) by application of a spectral deconvolution method. The results found (pKa = 9.48; pKb = 9.71; pKc = 10.12 and pKd = 9.88) are in good concordance with those obtained from the conventional regression linear method (pKa = 9.45; pKb = 9.77; pKc = 10.14 and pKd = 9.81).
authors.affiliation: Departamento de Quimica Fisica, Facultad de Farmacia, Granada, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Quintero
authors.forename: E
authors.initials: E
authors.lastname: Baena
authors.forename: M C
authors.initials: MC
authors.lastname: Cabeza
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: J M
authors.initials: JM
authors.lastname: Alvarez
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010656:Phenylephrine / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D010656:Phenylephrine