Detection of herpes simplex virus DNA in a cutaneous squamous cell carcinoma by in situ hybridization.
A case of a cutaneous squamous cell carcinoma (SCC) occurring at the site of a long-standing recurrent HSV infection is described. No deficit of the cell-mediated immunity was recorded. HSV2 was isolated in several viral cultures. HSV DNA was visualized in the SCC by in situ hybridization with biotinylated probes in paraffin-embedded tissue. The samples were negative for HPV2, 5, 16, and 18 probes. A causal relationship between HSV infection and cutaneous SCC is hypothesized.
Claudy
A L
AL
Service de Dermatologie, University Hospital, CHRU, St Etienne, France.
Chignol
M C
MC
Chardonnet
Y
Y
D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012008:Recurrence; D018139:Simplexvirus / Q000235:genetics*; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics*
D015342:DNA Probes; D004279:DNA, Viral