title: HM-PAO-imaging and herpes encephalitis.
abstract: Selective uptake of the cerebral blood-flow imaging agent 99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.
authors.affiliation: Department of Pathological Sciences, Medical School, University of Manchester, England.
authors.forename: G M
authors.initials: GM
authors.lastname: Cleator
authors.forename: A G
authors.initials: AG
authors.lastname: Lewis
authors.forename: P E
authors.initials: PE
authors.lastname: Klapper
authors.forename: H L
authors.initials: HL
authors.lastname: Sharma
authors.forename: A M
authors.initials: AM
authors.lastname: Smith
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006566:Herpesviridae Infections / Q000000981:diagnostic imaging*; D006801:Humans; D007124:Immunoenzyme Techniques; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010091:Oximes / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D018139:Simplexvirus / Q000378:metabolism*; D019690:Technetium Tc 99m Exametazime; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime