title: (8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.
authors.affiliation: Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
authors.forename: R D
authors.initials: RD
authors.lastname: Clark
authors.forename: D B
authors.initials: DB
authors.lastname: Repke
authors.forename: A T
authors.initials: AT
authors.lastname: Kilpatrick
authors.forename: C M
authors.initials: CM
authors.lastname: Brown
authors.forename: A C
authors.initials: AC
authors.lastname: MacKinnon
authors.forename: R U
authors.initials: RU
authors.lastname: Clague
authors.forename: M
authors.initials: M
authors.lastname: Spedding
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000317:Adrenergic alpha-Antagonists; D007546:Isoquinolines; D009287:Naphthyridines; C060956:Delequamine