[Effects of psychotropic drugs of the phenothiazine series on matrix activity of thymocyte DNA and glucocorticoid receptor interactions].
The experiment on adrenalectomized rats has shown that the concentration rates of 3.5.10(-4)M aminazine and 7.0.10(-4)M tizercine reduce 3H-acetonide triamcinolone-receptor interaction, and the concentration rate of 7.0.10(-4) tizercine increases 3H-cortisol receptor interaction in liver cytosol. The concentration rates of 3.5.10(-7)M aminazine and 3.5.10(-5)M tizercine suppress 3H-uridine inclusion into the acid-resisting mRNA thymocyte fraction. Associated introduction of aminazine and tizercine with acetonide triamcinolone (10(-8)M) increases the inhibiting effect on 3H-uridine inclusion into mRNA thymocytes. This suggests that aminazine and tizercine suppress matrix activity of DNA thymocytes through their effect on glucocorticoid receptors of type II.
Golikov
P P
PP
D000315:Adrenalectomy; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004247:DNA / Q000187:drug effects*; D006854:Hydrocortisone; D008297:Male; D008728:Methotrimeprazine / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*; D014222:Triamcinolone Acetonide
D014150:Antipsychotic Agents; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; C029360:hydrocortisone receptor; C039250:triamcinolone acetonide receptor; D004247:DNA; D008728:Methotrimeprazine; D014222:Triamcinolone Acetonide; D002746:Chlorpromazine; D006854:Hydrocortisone
Vliianie psikhotropnykh lekarstvennykh stredstv fenotiazinovogo riada na matrichnuiu aktivnost' DNK timotsitov i gliukokortikoidretseptornoe vzaimodeĭstvie.