[Early stages of hepatic carcinogenesis after vagotomy].
Initial stages of hepatocarcinogenesis have been studied in nonoperated and vagotomized animals. As a carcinogenic substance diethylnitrosamine (DENA) has been used. In order to estimate manifestation of the changes, the histochemical method for revealing glucoso-6-phosphatase activity, adenosine triphosphatase and gamma-glutamyltranspeptidase in the liver has been applied. The disturbance of vagus innervation is stated to delay the course of early stages of hepatocarcinogenesis, induced with DENA.
Dubovaia
T K
TK
Kobliakov
V A
VA
Merkulova
I B
IB
Politova
S N
SN
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D004052:Diethylnitrosamine; D004789:Enzyme Activation; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000294:innervation / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D051381:Rats; D013997:Time Factors; D014628:Vagotomy; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004052:Diethylnitrosamine; D005954:Glucosephosphate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000251:Adenosine Triphosphatases
Rannie étapy gepatokantserogeneza na fone vagotomii.