title: [Pathophysiologic-nephrologic hypothesis of the protective function of an endogenous natriuretic and digoxin-like substance (endoxin) for residual nephrons].
abstract: A dualistic function for the natriuretic ATP.inhibiting factor is formulated on the basis of a phenomenon like compensatory renal adaption of residual nephrons: 1. Support of the tubular sodium excretion to the maintenance of homoeostasis of the organism. 2. Inhibition of the forced up vasodilation of the afferent glomerular vessel. It should suggested that the renal vasoconstrictive effect is a part of a protective system for residual nephrons against the pathogenic hyperfiltration and hyperperfusion.
authors.affiliation: Abt. Pathophysiologie, Wilhelm-Pieck-Universität Rostock.
authors.forename: P W
authors.initials: PW
authors.lastname: Wüstenberg
authors.forename: L
authors.initials: L
authors.lastname: Schumann
authors.forename: H
authors.initials: H
authors.lastname: Klinkmann
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001798:Blood Proteins / Q000502:physiology*; D002298:Cardenolides; D004077:Digoxin; D005919:Glomerular Filtration Rate / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D009392:Nephrectomy; D009399:Nephrons / Q000503:physiopathology*; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D009320:Atrial Natriuretic Factor; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Pathophysiologisch-nephrologische Hypothese zur protektiven Funktion der endogenen natriuretischen und digoxinähnlichen Substanz (Endoxin) für Residualnephrone.