[Dependence of the degree of cardiac stress damages on the change in the endogenous beta-endorphin level during preliminary adaptation].
It was found that simulation of stress of the white rats increases the myocardial uptake of Tc-99m-pyrophosphate (Tc-pyp). The before-adapted group of animals had a sufficiently lower content of Cc-PYP in myocardium, than the stress-control group. At that time, the before-adaptation led to a low rise in the plasma beta-endorphin and to a significant rise in its quantity. The authors discuss the role of endogenous beta-endorphin in the mechanisms of the protecting effect of adaptation.
Maslova
L V
LV
Lishmanov
Iu B
IuB
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D011756:Diphosphates / Q000493:pharmacokinetics; D006331:Heart Diseases / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013667:Technetium / Q000493:pharmacokinetics; D016698:Technetium Tc 99m Pyrophosphate; D013997:Time Factors; D001615:beta-Endorphin / Q000032:analysis / Q000502:physiology*
D011756:Diphosphates; D010936:Plant Extracts; D016698:Technetium Tc 99m Pyrophosphate; D001615:beta-Endorphin; D013667:Technetium
Zavisimost' stepeni stressornykh povrezhdeniĭ serdtsa ot izmeneniia urovnia éndogennogo beta-éndorfina v khode predvaritel'noĭ adaptatsii.