title: Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine.
abstract: Ammonium salts added to isolated rat liver mitochondria deviate alpha-ketoglutarate to glutamate synthesis, thus decreasing its availability as respiratory substrate. As a consequence a decrease of respiratory rate is observed which is paralleled by progressive mitochondrial swelling. It was demonstrated that L-carnitine may abolish this swelling thus improving structural and metabolic state of mitochondria.
authors.affiliation: Institute of General Pathology, Modena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bellei
authors.forename: D
authors.initials: D
authors.lastname: Battelli
authors.forename: D M
authors.initials: DM
authors.lastname: Guarriero
authors.forename: U
authors.initials: U
authors.lastname: Muscatello
authors.forename: F
authors.initials: F
authors.lastname: DiLisa
authors.forename: N
authors.initials: N
authors.lastname: Siliprandi
authors.forename: V
authors.initials: V
authors.lastname: Bobyleva-Guarriero
mesh_terms: D000085:Acetates / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007656:Ketoglutaric Acids / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000085:Acetates; D005971:Glutamates; D007656:Ketoglutaric Acids; D000643:Ammonium Chloride; D018698:Glutamic Acid; D000244:Adenosine Diphosphate; C018824:ammonium acetate; D002331:Carnitine