Evidence for alpha 1-adrenoceptor subtype predominance in the rat seminal vesicle.
Noradrenaline (0.6-19 microM) and phenylephrine (2-130 microM) induced contractions in the rat seminal vesicle that were competitively antagonized by the alpha 1-adrenoceptor-selective antagonist corynanthine (120-920 nM). Yohimbine (60-450 nM), an alpha 2-adrenoceptor-selective antagonist, produced a non-competitive antagonism of noradrenaline responses, suggesting that the responses were not alpha 2-adrenoceptor mediated. It is concluded that the rat seminal vesicle has a predominance of alpha 1-adrenoceptors.
Adenekan
O O
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Department of Pharmacology, Obafemi Awolowo College of Health Sciences, Ogun State University, Sagamu, Nigeria.
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012669:Seminal Vesicles / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D015016:Yohimbine; D009638:Norepinephrine