Increased lipid peroxidation in malignant tissues of patients with colorectal cancer.
The authors investigated the level of lipid peroxidation and possible related phenomena in the activation of phospholipase A2 and the infiltration of granulocyte neutrophils in human colorectal cancer tissue samples. Malondialdehyde (an index of lipid peroxidation), phospholipase A2 activity, and myeloperoxidase activity (a marker of granulocyte neutrophils) were found to be increased significantly in cancerous compared with macroscopically normal tissues. They concluded that increased lipid peroxidation, phospholipase A2, and myeloperoxidase activity are associated with human colorectal cancer.
Otamiri
T
T
Department of Surgery, Linköping University Hospital, Sweden.
Sjödahl
R
R
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis; D010741:Phospholipases A / Q000032:analysis; D054467:Phospholipases A2
D008315:Malondialdehyde; D009195:Peroxidase; D010741:Phospholipases A; D054467:Phospholipases A2