title: In vitro and in vivo studies on triclosan/PVM/MA copolymer/NaF combination as an anti-plaque agent.
abstract: A combination of triclosan, copolymer of PVM/MA and NaF has been optimized in vitro and in vivo for plaque effect. Triclosan (2, 4, 4' trichloro-2'-hydroxydiphenyl ether), a non-cationic antibacterial, was compatible with anionic surfactant, NaF and PVM/MA copolymer as evaluated by in vitro antibacterial tests. The in vitro uptake of triclosan on the saliva-coated hydroxyapatite disks, extracted human teeth and oral buccal epithelial cells was enhanced two fold in the presence of PVM/MA copolymer when compared to the uptake in the absence of the copolymer. The combination consisting of 0.3% triclosan/2% PVM/MA copolymer/1100 ppm NaF was found to be highly effective on reducing smooth and fissure caries, and plaque extent compared to to 1100 ppm/NaF by itself in rats when applied topically. The combination also showed significantly more fluoride uptake and reduction in enamel solubility than 1100 ppm/NaF. The results of these studies indicated that this optimized combination was an effective antiplaque/anticaries agent in vitro and in vivo.
authors.forename: N
authors.initials: N
authors.lastname: Nabi
authors.forename: C
authors.initials: C
authors.lastname: Mukerjee
authors.forename: R
authors.initials: R
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Gaffar
mesh_terms: D000818:Animals; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control*; D017886:Durapatite; D006801:Humans; D006882:Hydroxyapatites; D008298:Maleates / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D010647:Phenyl Ethers / Q000627:therapeutic use*; D011145:Polyvinyls / Q000627:therapeutic use*; D051381:Rats; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D006882:Hydroxyapatites; D008298:Maleates; D010647:Phenyl Ethers; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan; D012969:Sodium Fluoride; D017886:Durapatite