Efficiency of arsenic clearance from human blood in vitro and from dogs in vivo by extracorporeal complexing haemodialysis.
In vitro dialysis using human blood and in vivo extracorporeal haemodialysis trials with dogs, in the presence and absence of various chelating agents, showed that haemodialysis alone facilitated efficient removal of the metal, even in the absence of any of the chelating agents. In vitro haemodialysis for 5 hr without chelating agents caused the removal of 85% of the arsenic (As) added to the blood 1 hr before the beginning of the treatment. Ten-33% of the single dose given to the dogs, were removed into the dialysate during the first treatment and 8-15% during the second. The amounts of As excreted in the urine of dogs given 0.25 mg As/kg b.wt./day for 6 days were 6.8-7.4 mg As/24 hr, while the same amounts of the metal were removed into the dialysate during haemodialysis for 5 hr. This demonstrates the advantage of employing haemodialysis over the conventional treatment for the enhanced removal of As from the body.
Sheabar
F Z
FZ
Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa.
Yannai
S
S
Taitelman
U
U
D000818:Animals; D001151:Arsenic / Q000097:blood*; D018053:Arsenites; D002614:Chelating Agents / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005978:Glutathione / Q000097:blood; D006464:Hemoperfusion; D006801:Humans; D007202:Indicators and Reagents; D006435:Renal Dialysis; D004113:Succimer / Q000494:pharmacology
D018053:Arsenites; D002614:Chelating Agents; D007202:Indicators and Reagents; D004113:Succimer; D005978:Glutathione; C015001:arsenite; D001151:Arsenic