Is the Epstein-Barr virus involved in Hodgkin's disease?
EBV genomes, in clonal episomal form, were detected in 7 out of 17 cases of Hodgkin's disease (HD) and in a single case of non-Hodgkin's lymphoma which occurred in a patient after therapeutic treatment for HD. The experimental data presented imply that a clonal cell population, harboring the EBV genome, must be present in EBV-positive HD. In light of this finding we are attempting to reconsider the abundant literature on this lymphoproliferative disorder, and suggest a reevaluation of the possibility that EBV could be etiologically involved in HD.
Boiocchi
M
M
Division of Experimental Oncology 1, Aviano, Italy.
Carbone
A
A
De Re
V
V
Dolcetti
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D007108:Immune Tolerance; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology; D008297:Male; D008875:Middle Aged