title: Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10.
abstract: The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10.
authors.affiliation: Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.
authors.forename: D M
authors.initials: DM
authors.lastname: Schonk
authors.forename: H J
authors.initials: HJ
authors.lastname: Kuijpers
authors.forename: E
authors.initials: E
authors.lastname: van Drunen
authors.forename: C H
authors.initials: CH
authors.lastname: van Dalen
authors.forename: A H
authors.initials: AH
authors.lastname: Geurts van Kessel
authors.forename: R
authors.initials: R
authors.lastname: Verheijen
authors.forename: F C
authors.initials: FC
authors.lastname: Ramaekers
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D015870:Gene Expression; D006801:Humans; D006822:Hybrid Cells; D015151:Immunoblotting; D009687:Nuclear Proteins / Q000235:genetics*; D018809:Proliferating Cell Nuclear Antigen
chemical_list: D000911:Antibodies, Monoclonal; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen