Role of cholecystokinin in regulation of gastrointestinal motor functions.
By means of loxiglumide, a potent and highly specific antagonist for cholecystokinin (CCK), the effects of blocking CCK receptors on gastrointestinal motility were investigated in a placebo-controlled study in healthy young men (aged 21-39, mean 24 years). Gallbladder contraction stimulated by ingestion of a liquid test meal was completely abolished by oral administration of loxiglumide 30 min before the test meal. Gastric emptying of radio-opaque markers ingested with the test meal was significantly accelerated by loxiglumide (area under the curve [markers x h] 33.3 [SEM 3.8] vs 17.9 [2.7] after placebo). No effect of loxiglumide was found on small-bowel transit time, but 7 days' treatment with oral loxiglumide (800 mg three times daily) significantly shortened colonic transit time (29.4 [4.1] h after placebo, 15.0 [3.4] h after loxiglumide). It is concluded that CCK is an important mediator of meal-induced gallbladder contraction and is involved in the regulation of gastrointestinal motility in man.
Meyer
B M
BM
Division of Gastroenterology, University Hospital, Basle, Switzerland.
Werth
B A
BA
Beglinger
C
C
Hildebrand
P
P
Jansen
J B
JB
Zach
D
D
Rovati
L C
LC
Stalder
G A
GA
D010129:4-Aminobenzoic Acid; D000284:Administration, Oral; D000328:Adult; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000097:blood / Q000502:physiology*; D002986:Clinical Trials as Topic; D003106:Colon / Q000502:physiology; D004341:Drug Evaluation; D004435:Eating; D005704:Gallbladder / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000502:physiology; D008297:Male; D011377:Proglumide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D011897:Random Allocation; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D062366:para-Aminobenzoates
D011949:Receptors, Cholecystokinin; D062366:para-Aminobenzoates; C006717:bentiromide; C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide; D010129:4-Aminobenzoic Acid