Relationship between acupuncture-induced immunity and the regulation of central neurotransmitter system in rabbits--II. Effect of the endogenous opioid peptides on the regulation of acupuncture-induced immune reaction.
By injecting Naloxone, the T-lymphocyte transformation was reduced markedly. When the Naloxone plus electro-acupuncture were used together, it was not reduced but was still lower than it was when only electro-acupuncture was used. This explained why Naloxone could reverse the function by which electro-acupuncture promoted the T-lymphocyte transformation, and the endogenous opioid in the brain promoted the immune reaction. Through promoting the release of the endogenous opioid in the brain, electro-acupuncture raised the T-lymphocyte transformation function. Using electro-acupuncture when naloxone antagonized morphine, the T-lymphocyte transformation function was still promoted markedly. The mechanism could be that electro-acupuncture excited the function of the endogenous opioid system in the brain. In acupuncture immune reaction, the relationship between the endogenous opioid and catecholaminergic systems was explored.
Zhao
J C
JC
Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, People's Republic of China.
Liu
W Q
WQ
D015670:Acupuncture Therapy; D000818:Animals; D001921:Brain / Q000502:physiology; D004558:Electric Stimulation; D004723:Endorphins / Q000502:physiology*; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009113:Muramidase / Q000097:blood; D009270:Naloxone / Q000494:pharmacology; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D004723:Endorphins; D009270:Naloxone; D009020:Morphine; D009113:Muramidase