title: Should the Cytobrush be used in routine screening for cervical pathology?
abstract: In 632 women visiting a family planning clinic, paired cervical smears were taken using a wooden spatula and a Cytobrush. Of the spatula smears 7.8% were unreliable with too little or scanty material to allow a cytologic diagnosis (class 0); 17.7% of spatula smears were inadequate, lacking endocervical cells. Combined spatula/Cytobrush cytology reduced these figures significantly; 4.3% unreliable smears and 3.2% inadequate specimens. Seventy-three (11.6%) of the smears revealed some abnormality, in most cases Papanicolaou class IIIA, suggestive of mild dysplasia. In 10 cases, dysplastic cells were found only in the Cytobrush cytology. It is concluded that the Cytobrush adds to the improvement of smear quality and the accuracy of routine cervical cytology obtained by relatively inexperienced smear takers.
authors.affiliation: Department of Obstetrics and Gynecology, Leyenburg Hospital, The Hague, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: van Erp
authors.forename: M C
authors.initials: MC
authors.lastname: Dersjant-Roorda
authors.forename: N P
authors.initials: NP
authors.lastname: Arentz
authors.forename: T
authors.initials: T
authors.lastname: Stijnen
authors.forename: J B
authors.initials: JB
authors.lastname: Trimbos
mesh_terms: D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D011446:Prospective Studies; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears / Q000295:instrumentation / Q000379:methods*
chemical_list: D003276:Contraceptives, Oral