title: High field localized proton spectroscopy in small volumes: greatly improved localization and shimming using shielded strong gradients.
abstract: The availability of shielded gradients facilitates accurate single-voxel spectroscopy. Exact localization (90-99%) of volumes as small as 2 x 2 x 2 mm is demonstrated using a modified stimulated echo sequence. Strong gradient pulses (up to 200 mT/m) are employed to clear the stimulated echo of unwanted magnetization, enabling superior (single-scan) shimming of the selected volume. In vivo and in vitro proton NMR results at 4.7 T are presented.
authors.affiliation: Clinical Pharmacology Branch, NCI, National Institutes of Health, Bethesda, Maryland.
authors.forename: P C
authors.initials: PC
authors.lastname: van Zijl
authors.forename: C T
authors.initials: CT
authors.lastname: Moonen
authors.forename: J R
authors.initials: JR
authors.lastname: Alger
authors.forename: J S
authors.initials: JS
authors.lastname: Cohen
authors.forename: S A
authors.initials: SA
authors.lastname: Chesnick
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002415:Cats; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons
chemical_list: D011522:Protons