Lipolysis by corticotropin in fat cells from hypothyroid rats. Effect of adenosine deaminase.
Thyroid hormones are required for maximal stimulation of lipolysis of fat cells by catecholamines corticotropin and glucagon. Several reasons have been given to explain this fact, but all of them are controversial and still not definitive. It has been proposed that adenosine is an important factor in the low lipolytic response to catecholamines by fat cells of hypothyroid rats. This proposal has been studied with corticotropin. There has been no recuperation of maximal lipolysis when fat cells of hypothyroid rats were stimulated by corticotropin in the presence of adenosine deaminase.
Gandarias
J M
JM
Departamento de Fisiología, Facultad de Medicina, Universidad del País Vasco, Bilbao, Spain.
Goiriena
J J
JJ
Ainz
F
F
Rueda
E
E
Fernández
B M
BM
D000243:Adenosine Deaminase / Q000494:pharmacology*; D000273:Adipose Tissue / Q000166:cytology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007037:Hypothyroidism / Q000201:enzymology / Q000378:metabolism*; D008066:Lipolysis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009700:Nucleoside Deaminases / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000324:Adrenocorticotropic Hormone; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase