[The effect of colchicine and its derivatives on the activity of enzyme markers of T-lymphocytes].
Colchicine and its less toxic derivatives (demecolcine and deacetyl colchicine), in dependence on the concentration in the incubation medium, inhibited the activity of adenosine deaminase in the lymphocytes. All the three substances increased the level of cyclic adenosine monophosphate which has the ability of influencing the proliferation of T-lymphocytes. Colchicine and its derivates also inhibited the activity of purine nucleooxidophosphorylase, which, similarly as adenosine deaminase, is a marker enzyme of T-lymphocytes. The results obtained lead to the assumption that the mentioned preparations inhibit the function of T-lymphocytes.
Mikulíková
D
D
Lukác
J
J
Ondrasík
M
M
D000243:Adenosine Deaminase / Q000378:metabolism; D003078:Colchicine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D003703:Demecolcine / Q000494:pharmacology; D006801:Humans; D013601:T-Lymphocytes / Q000201:enzymology*
C003707:trimethylcolchicinic acid methyl ether; D000242:Cyclic AMP; D000243:Adenosine Deaminase; D003078:Colchicine; D003703:Demecolcine
Vplyv kolchicínu a jeho derivátov na aktivitu markerových enzýmov T-lymfocytov.