Dopamine and ventilatory effects of hypoxia and almitrine in chronically hypoxic rats.
We hypothesized that the temporary blunted ventilatory response to hypoxia seen in chronically hypoxic rats could be related to the increased amount of dopamine found in their carotid bodies. Rats, kept 2-3 wk in 10% O2, showed reduced nonisocapnic ventilatory responses to 21-12% inspiratory O2 fraction compared with control rats. Stimulus-response curves to almitrine, which simulates the action of hypoxia on the carotid body, were also depressed in chronically hypoxic rats. Responses to hypoxia and almitrine were significantly correlated in the two groups of rats. Dopamine depressed ventilation during normoxia, hypoxia, and almitrine stimulation in both groups, an action abolished by the dopamine-2 antagonist domperidone. Domperidone slightly increased responses to hypoxia and almitrine in control rats but had a greater enhancing effect in chronically hypoxic rats, such that there was no longer a difference between the responses of the two groups.
Wach
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Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, United Kingdom.
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D015765:Almitrine; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002908:Chronic Disease; D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*
D000697:Central Nervous System Stimulants; D018492:Dopamine Antagonists; D010879:Piperazines; D004294:Domperidone; D015765:Almitrine