[Effect of vasopressin on the osmotic permeability of the bladder wall in the frog and its content of cAMP, cGMP and inositol triphosphate].
An increase in the water permeability of the frog urinary bladder due to vasopressin, correlates with an increase of cAMP content in the bladder tissue. The osmotic permeability reached its maximum in 15-20 min. The sharp increase of inositol triphosphate content was observed within 20 sec after vasopressin administration, whereas cGMP content significantly decreased within 5 min. The augmentation of cAMP content seems to lead to a rise in water permeability white inositol triphosphate and cGMP acted, probably, as modulators of the vasopressin effect.
Natochin
Iu V
IuV
Parnova
R G
RG
Reznik
L V
LV
Natochin
M Iu
MIu
Firsov
D L
DL
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis / Q000502:physiology*; D006152:Cyclic GMP / Q000032:analysis / Q000502:physiology*; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000032:analysis / Q000502:physiology*; D009995:Osmosis / Q000187:drug effects*; D011896:Rana temporaria; D015290:Second Messenger Systems / Q000187:drug effects; D013403:Sugar Phosphates / Q000502:physiology*; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology*
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D014667:Vasopressins; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D006152:Cyclic GMP
Vliianie vazopressina na osmoticheskuiu pronitsaemost' stenki mochevogo puzyria liagushki i soderzhanie v neĭ tsAMF, tsGMF i inozittrifosfata