title: Aromatase activity in cultured ovaries from fetal and neonatal golden hamsters.
abstract: The production of oestrogen from androstenedione by ovaries of hamsters on day 14 of pregnancy and on days 0 and 3 after birth was investigated by culturing these ovaries for 48 h in serum-free medium containing insulin and [3H]androstenedione. Both oestrone and oestradiol-17 beta were produced in culture of ovaries on day 14 of pregnancy. The production of oestrogen increased about 2-fold in culture of ovaries on days 0 and 3. Dibutyryladenosine 3':5'-cyclic monophosphate stimulated the oestrogen production by ovaries on day 14 of pregnancy and on days 0 and 3. The present results indicate that the ovaries of fetal and neonatal hamsters have an aromatase activity and that these aromatase activities are responsive to adenosine 3':5'-cyclic monophosphate.
authors.affiliation: Department of Experimental Pathology, Osaka University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Terada
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: D
authors.initials: D
authors.lastname: Takatsuka
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001141:Aromatase / Q000378:metabolism*; D002478:Cells, Cultured; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000166:cytology / Q000201:enzymology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D008647:Mesocricetus; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*
chemical_list: D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D001141:Aromatase