title: [Cyclic adenosine monophosphate in the cerebrospinal fluid of patients with brain trauma and diseases].
abstract: The authors studied adenosine 3,5-cyclic monophosphate (cAMP) in the cerebrospinal fluid (csf) of patients with craniocerebral trauma (CCT), ischemic stroke, and brain tumors. A statistically significant increase of cAMP in csf of patients with moderate and severe CCT was revealed. In unfavourable outcomes of severe CCT the increase of cAMP continued to the time of death. The authors suggest using this index as a diagnostic criterion of the depth of the metabolic disorders in the brain tissue, as a prognostic criterion, and for purposes of differential diagnosis. The possible mechanism of lipid peroxidation activation in CCT is discussed.
authors.forename: V I
authors.initials: VI
authors.lastname: Skorniakov
authors.forename: L A
authors.initials: LA
authors.lastname: Kozhemiakin
authors.forename: A S
authors.initials: AS
authors.lastname: Popov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D001930:Brain Injuries / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000175:diagnosis; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis; D002648:Child; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000242:Cyclic AMP
vernacular_title: Tsiklicheskiĭ adenozinmonofosfat v spinnomozgovoĭ zhidkosti u bol'nykh s travmami i zabolevaniiami golovnogo mozga.