Gestational trophoblastic disease: a case-control study from the People's Republic of China.
A case-control study involving 331 patients with complete hydatidiform mole and 662 community controls matched to the cases on age and timing of pregnancy was conducted in Beijing, China. A history of a term birth was associated with reduced risk (odds ratio = 0.6, 95% confidence interval 0.4 to 0.9), with some evidence of further decrease with multiple births. Previous spontaneous abortions were not related to risk, although those with a prior induced abortion were at elevated risk, particularly if two or more abortions were involved (odds ratio = 2.8, 95% confidence interval 1.4 to 5.7). A history of having sought medical advice for infertility was associated with reduced risk (odds ratio = 0.5, 95% confidence interval 0.2 to 0.8), but those who reported use of herbal medicines during a first trimester of a previous pregnancy were at excess risk (odds ratio = 2.2, 95% confidence interval 1.3 to 3.6). In addition, a statistically significant trend in risk was observed with years of oral contraceptive use (odds ratio = 2.6, 95% confidence interval 0.9 to 6.9 for greater than or equal to 4 years of use). Dietary habits and family histories of cancer or trophoblastic disease were not related to risk in this study.
Brinton
L A
LA
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.
Wu
B Z
BZ
Wang
W
W
Ershow
A G
AG
Song
H Z
HZ
Li
J Y
JY
Bracken
M B
MB
Blot
W J
WJ
D000328:Adult; D000367:Age Factors; D002681:China; D003276:Contraceptives, Oral / Q000009:adverse effects; D004032:Diet; D005260:Female; D006801:Humans; D007246:Infertility; D007434:Intrauterine Devices; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D012098:Reproduction; D014328:Trophoblastic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000209:etiology*
D003276:Contraceptives, Oral