title: Inhibitory effect of pyrophosphate, citrate, magnesium and chondroitin sulphate in calcium oxalate urolithiasis.
abstract: The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone-forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.
authors.affiliation: Department of Chemistry, University of the Balearic Islands, Palma de Mallorca, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Grases
authors.forename: C
authors.initials: C
authors.lastname: Genestar
authors.forename: A
authors.initials: A
authors.lastname: Conte
authors.forename: P
authors.initials: P
authors.lastname: March
authors.forename: A
authors.initials: A
authors.lastname: Costa-Bauzá
mesh_terms: D002129:Calcium Oxalate / Q000652:urine; D002807:Chondroitin; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D003460:Crystallization; D011756:Diphosphates / Q000627:therapeutic use*; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D014545:Urinary Calculi / Q000517:prevention & control* / Q000652:urine
chemical_list: D002951:Citrates; D011756:Diphosphates; D002129:Calcium Oxalate; D019343:Citric Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates; D008274:Magnesium; C003319:sodium pyrophosphate