[Beta blockaders and physical performance. Limiting factors].
Beta blockers are known to cause reduced exercise performance in hypertensive and healthy subjects. Additive effects of selective blockade of beta-1 and beta-2 receptor subtypes seems to account for the total reduction in exercise capacity observed with non-selective beta-1,2 blockade. The mechanism is as yet undefined. The magnitude of the reduction is dependent of type of exercise and level of fitness. Hemodynamic parameters, substrate delivery to the working muscles, mental factors, and interference with potassium homeostasis may be involved.
Gullestad
L
L
Dolva
L O
LO
Søyland
E
E
Kjekshus
J
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D015444:Exercise; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000378:metabolism
D000319:Adrenergic beta-Antagonists
Betablokkere og fysisk arbeidstoleranse. Begrensende faktorer.