title: Peculiarities of receptor-channel complexes for inhibitory mediators in the membranes of lamprey spinal cord neurones.
abstract: Effects of inhibitory mediators on the membranes of isolated lamprey spinal cord neurones were investigated by means of whole-cell recording and concentration clamp techniques. Glycine and gamma-aminobutyric acid (GABA) applications evoked desensitizing chloride currents. The concentrations at half-maximum effects were 16 microM for glycine- and 1.5 mM for GABA-activated currents. Ionic responses to applications of both amino acids demonstrated full cross-desensitization. Strychnine and bicuculline suppressed both glycine- and GABA-activated conductances to the same degree. We suggest that in the membranes of lamprey spinal cord neurones glycine and GABA act on the same receptor-channel complexes.
authors.affiliation: A.A. Bogomoletz Institute of Physiology, Ukrainian Academy of Sciences, Kiev, U.S.S.R.
authors.forename: B V
authors.initials: BV
authors.lastname: Safronov
authors.forename: K V
authors.initials: KV
authors.lastname: Baev
authors.forename: I V
authors.initials: IV
authors.lastname: Batueva
authors.forename: K I
authors.initials: KI
authors.lastname: Rusin
authors.forename: E I
authors.initials: EI
authors.lastname: Suderevskaya
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005399:Fishes / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007798:Lampreys / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D017981:Receptors, Neurotransmitter; D005680:gamma-Aminobutyric Acid; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline