title: A new DNA marker tightly linked to the fragile X locus (FRAXA).
abstract: The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.
authors.affiliation: Department of Histopathology, Adelaide Children's Hospital, Australia.
authors.forename: G K
authors.initials: GK
authors.lastname: Suthers
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: V J
authors.initials: VJ
authors.lastname: Hyland
authors.forename: H M
authors.initials: HM
authors.lastname: Kozman
authors.forename: E
authors.initials: E
authors.lastname: Baker
authors.forename: H
authors.initials: H
authors.lastname: Eyre
authors.forename: P S
authors.initials: PS
authors.lastname: Harper
authors.forename: S H
authors.initials: SH
authors.lastname: Roberts
authors.forename: M C
authors.initials: MC
authors.lastname: Hors-Cayla
authors.forename: K E
authors.initials: KE
authors.lastname: Davies
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D005817:Genetic Counseling; D008040:Genetic Linkage; D005819:Genetic Markers; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D016013:Likelihood Functions; D051379:Mice; D016532:Mucopolysaccharidosis II / Q000235:genetics; D009154:Mutation; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers