[Cyclic analogs of ACTH fragments in self-stimulation and grooming behavior in rabbits].
In present study new cyclic fragments of ACTH EHFRWGKPVG--NH2 and KHFRWG--NH2 were investigated in organization of self-stimulation and grooming behaviour in rabbits. Intracerebroventricular injections of EHFRWGPVG--NH2 in doses of 0.1-2.5 g evoked significant increases of self-stimulation and in doses of 4-5 g suppressed self-stimulation in rabbits. The effect of other fragments KHFRWG--NH2 on self-stimulation was not statistically significant. Both fragments induced excessive grooming behaviour in rabbits. The effects of these fragments persisted of 48-72 hours.
Burchuladze
R A
RA
Liepkaula
I K
IK
Romanovskiĭ
P Ia
PIa
Chipens
G I
GI
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles; D006120:Grooming / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone
Tsiklicheskie analogi fragmentov AKTG v organizatsii povedeniia samorazdrazheniia i gruminga u krolikov.