In vitro studies on tin-dithiocarbamates.
Organotin compounds have been studied for their biological properties, whereas very little is known about the effects of tin-inorganic derivatives on biological systems. Owing to our interest in the dithiocarbamate moiety in relation to metal redistribution in the body and to its biological import, we performed in vitro cytotoxicity experiments on dithiocarbamates. Preliminary results obtained with five tin-dithiocarbamates, where DDTC is the diethyldithiocarbamate anion, indicate some very promising compounds.
Carrara
M
M
Department of Pharmacology, University of Padova, Italy.
Cima
L
L
Zampiron
S
S
Preti
C
C
Cherchi
V
V
Sindellari
L
L
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D014001:Tin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D014001:Tin; D004050:Ditiocarb