title: Effect of vitamin C, environmental temperature, chlortetracycline, and vitamin D3 on the development of tibial dyschondroplasia in chickens.
abstract: Seven experiments were conducted to test the influence of dietary supplementary ascorbic acid on the development of tibial dyschondroplasia in broiler chickens. Ascorbic acid supplementation significantly reduced the incidence and number of birds with a large mass of cartilage in the tibia in the first experiment but not in the two subsequent experiments. Because environmental temperature, microbial infection, and vitamin D3 status had been reported in the literature to influence ascorbic acid metabolism in the chicken, experiments were conducted to see if these variables could influence supplemental ascorbic acid effects on development of tibial dyschondroplasia. Results of the experiments indicated that none of these factors influenced the effect of ascorbic acid on the development of tibial dyschondroplasia. The presence of vitamin D3 in the diet significantly influences the incidence of this disorder.
authors.affiliation: Department of Poultry Science, University of Georgia, Athens, 30602.
authors.forename: H M
authors.initials: HM
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002645:Chickens; D002751:Chlortetracycline / Q000627:therapeutic use; D002762:Cholecalciferol / Q000172:deficiency; D008297:Male; D010009:Osteochondrodysplasias / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000209:etiology / Q000517:prevention & control*; D013696:Temperature; D014808:Vitamin D Deficiency / Q000150:complications / Q000662:veterinary; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002762:Cholecalciferol; D001205:Ascorbic Acid; D002751:Chlortetracycline