Influence of long-term prenalterol treatment on the heart rate and the beta-adrenoceptor binding-sites in rat myocardium.
The density of beta- adrenoceptors has been determined on membranes prepared from rat myocardium. Long-term administration of prenalterol resulted in an increase in the density of receptors, without any change in affinity. The average heart rate increase induced by intravenous prenalterol administration to denervated rats was, however, similar in the prenalterol pretreated and the control groups. We conclude that long-term treatment with a partial beta1-adrenoceptor agonist lead to an increased beta-adrenoceptor density in the myocardium.
Ahlner
J
J
Department of Clinical Pharmacology, University Hospital, Linkoping, Sweden.
Andersson
R G
RG
Dahlström
U
U
Nylander
E
E
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011294:Prenalterol / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D011294:Prenalterol