HM-PAO-imaging and herpes encephalitis.
Selective uptake of the cerebral blood-flow imaging agent 99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.
Cleator
G M
GM
Department of Pathological Sciences, Medical School, University of Manchester, England.
Lewis
A G
AG
Klapper
P E
PE
Sharma
H L
HL
Smith
A M
AM
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006566:Herpesviridae Infections / Q000000981:diagnostic imaging*; D006801:Humans; D007124:Immunoenzyme Techniques; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010091:Oximes / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D018139:Simplexvirus / Q000378:metabolism*; D019690:Technetium Tc 99m Exametazime; D014709:Vero Cells
D000998:Antiviral Agents; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime