[The inhibitory effect of oxatomide, an anti-allergic agent, on eosinophil-mediated and eosinophilic cell line-mediated natural cytotoxicity against bronchial epithelial cells].
Recently, eosinophils have been implicated as inflammatory effector cells in allergic and inflammatory reactions such as bronchial asthma. In this study eosinophil-mediated and eosinophilic cell line-mediated natural cytotoxicity against bronchial epithelial cells and the effects of oxatomide, an anti-allergic agent, on their cytotoxicity were investigated. Treatment with oxatomide diminished both eosinophil-mediated and eosinophilic cell line-mediated natural cytotoxicity in vitro. We concluded from these results that oxatomide not only has anti-allergic activity but also anti-inflammatory properties for eosinophils. In addition this method for isolating eosinophils seems to well serve the purpose of evaluating eosinophil function as in this investigation, as we have reported previously.
Chihara
J
J
Sugihara
R
R
Kubo
H
H
Yamamoto
T
T
Nakano
N
N
Uenishi
H
H
Nakajima
S
S
D001980:Bronchi / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003864:Depression, Chemical; D004804:Eosinophils / Q000187:drug effects* / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D010879:Piperazines / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide