[The effect of prolonged antiorthostatic hypokinesia on the blood serum activity of enzymes involved in energy and plastic metabolism].
In the course of 370-day antiorthostatic (-5 degrees) hypokinesia in which 9 test subjects participated the following changes in serum enzymes associated with energy metabolism inhibition were recorded: decreases of creatine phosphokinase (CPK) at the expense of its MM-isoform, isocitrate and glutamate dehydrogenases as well as increases of alanine and aspartate aminotransferases, gamma-glutamyl transferase, and lactate dehydrogenase (LDH) at the expense of an increased portion of its aerobic H-isoforms. During the recovery period these parameters returned to the norm. The counter-measures used (drugs combined with exercise) exerted a beneficial effect only in relation to CPK, gamma-glutamyl transferase and aspartate aminotransferase.
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D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D004798:Enzymes / Q000097:blood*; D005969:Glutamate Dehydrogenase / Q000097:blood; D006801:Humans; D007103:Immobilization / Q000502:physiology*; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008297:Male; D011187:Posture / Q000502:physiology*; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
D004798:Enzymes; D007521:Isocitrate Dehydrogenase; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase
Vliianie dlitel'noĭ antiortostaticheskoĭ gipokinezii na aktivnost' fermentov énergeticheskogo i plasticheskogo obmena v syvorotke krovi.