Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry.
This study describes an investigation of the thermospray (TS) mass spectrometric analysis of tripelennamine, methapyrilene, thenyldiamine, and their N-oxide derivatives. These compounds were analyzed by direct injection TS mass spectrometry in the column bypass mode and with 0.1M ammonium acetate/methanol (80:20, v/v) as the mobile phase. Typically, the parent antihistamines produced only [MH]s ions under these conditions. The N-oxides provided strong [MH]s ions and multiple fragment ions. A scheme to explain the fragmentation patterns is proposed.
Korfmacher
W A
WA
Department of Health and Human Services, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Freeman
J P
JP
Hansen
E B
EB
Holder
C L
CL
Getek
T A
TA
D000631:Aminopyridines / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006634:Histamine H1 Antagonists / Q000032:analysis*; D008701:Methapyrilene / Q000031:analogs & derivatives / Q000032:analysis*; D011725:Pyridines / Q000032:analysis*; D014309:Tripelennamine / Q000031:analogs & derivatives / Q000032:analysis*
D000631:Aminopyridines; D006634:Histamine H1 Antagonists; D011725:Pyridines; D014309:Tripelennamine; D008701:Methapyrilene; C005822:thenyldiamine