[Comparison of the susceptibility of Candida strains to ketoconazole and itraconazole in in vitro experiments].
The activity of ketoconazole and itraconazole against 102 strains of Candida sp. was compared in the investigation "in vitro". The investigational material was taken from patients with different types of mycosis. The values of MICs of ketoconazole and itraconazole were 0.04-100.0 micrograms/ml and 0.02-35.0 micrograms/ml, respectively. From the data obtained it is evident that the average efficacy of itraconazole is 3 to 10 times higher in comparison with ketoconazole though 8 strains (7, 8 percent) of investigated strains have shown greater sensitivity to ketoconazole.
Gwieździński
Z
Z
Nierebińska
E
E
Urbanowski
S
S
D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole
Porównanie wraźliwości szczepów rodzaju Candida na ketokonazol i itrakonazol w badaniach in vitro.