title: Bidirectional transhemispheric interaction between amygdaloid kindling induced by excitatory amino acids and electrical stimulation.
abstract: Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP) in a molar ratio of 1:3 (GLU 0.375 microM:ASP 1.125 microM). Strong bidirectional transhemispheric transfer between electrical and chemical kindling occurred at the secondary-site AM. In addition, at the primary-site retest, bidirectional posttransfer interference between electrical and chemical kindling was observed. These findings strongly suggest that endogenous GLU/ASP participates in the transsynaptic changes which are presumed to underlie the kindling phenomenon.
authors.affiliation: Division of Neurosciences, University of British Columbia, Vancouver, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: J A
authors.initials: JA
authors.lastname: Wada
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007267:Injections; D007696:Kindling, Neurologic; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid