Use of enzyme histochemistry in the diagnosis of pancreatoblastoma.
The macroscopic, light microscopic and ultrastructural findings in a case of pancreatoblastoma in a neonate are presented. No evidence for exocrine or endocrine secretion could be found by histochemistry, immunocytochemistry or electron microscopy. However, enzyme histochemical techniques to localize activity of 'glucose-6-phosphatase', acid phosphatase, esterase and esteroprotease supported both a pancreatic origin for the tumour and a biphasic pattern of differentiation.
Cooper
J E
JE
Department of Histopathology, Hospital for Sick Children, London, UK.
Lake
B D
BD
D000135:Acid Phosphatase / Q000032:analysis; D004796:Clinical Enzyme Tests; D004950:Esterases / Q000032:analysis; D005952:Glucose-6-Phosphatase / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure; D012697:Serine Endopeptidases / Q000032:analysis
D004950:Esterases; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D012697:Serine Endopeptidases