[The effect of succinylcholine on vecuronium and pancuronium].
In 105 adult patients under halothane anesthesia, the neuromuscular blocking effects of vecuronium and pancuronium were determined with prior succinylcholine 1 mg.kg-1 administration and without. Force of the evoked twitch increased 123.7% of control after recovery from succinylcholine-induced block. Prior administration of succinylcholine was associated with a leftward shift of dose-response curve of vecuronium or pancuronium. Onset of the force reduction from initial dose (0.08 mg.kg-1) was faster and recovery from initial and maintenance doses (0.02 mg.kg-1) were slower. This potentiating effect persisted at least 2 hours.
Ono
K
K
Manabe
N
N
Ohta
Y
Y
Morita
K
K
Kosaka
F
F
D000328:Adult; D004357:Drug Synergism; D006801:Humans; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology*; D013390:Succinylcholine / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium