title: Low AIDS attack rate among Dutch haemophiliacs compared to homosexual men: a correlate of HIV antigenaemia frequencies.
abstract: A cohort of 180 haemophiliacs followed between 1983 and 1986 and a cohort of 961 homosexual men followed between 1984 and 1986 were compared for the prevalence and incidence of HIV-1 antibody (HIV-1-Ab) seropositivity, the incidence of AIDS-related complex (ARC) and AIDS and the prevalence and incidence of serological and immunological markers for HIV-related disease progression. Among the haemophiliacs 23 (12.8%) patients were HIV-1-Ab seropositive at entry and 20 (12.7%) of the remaining 157 seroconverted for HIV-1-Ab during follow-up. Of the homosexual men 238 (24.8%) were HIV-1-Ab seropositive at entry and 68 (9.4%) of the 723 at entry seronegatives seroconverted during follow-up. Clinical follow-up of the HIV-1-Ab seropositive and seroconverted men was 59 months in the haemophiliac cohort and 60 months in the homosexual cohort. Among the HIV-1-Ab seropositive and seroconverted haemophiliacs and homosexual men the cumulative ARC/AIDS incidence was 2 and 18%, respectively. Occurrence of HIV-1-antigenaemia was more frequent among seropositive and seroconverted homosexual men (28%) than among haemophiliacs (7%) (p = 0.001). The groups did not differ significantly for the absence or loss of anti-HIV core antibodies or the occurrence of low CD4+ cell numbers. These data indicate a slower progression of HIV-related disease in seropositive haemophiliacs compared to seropositive homosexual men.
authors.affiliation: Virology Department, University of Amsterdam, The Netherlands.
authors.forename: T F
authors.initials: TF
authors.lastname: Wolfs
authors.forename: F
authors.initials: F
authors.lastname: de Wolf
authors.forename: C
authors.initials: C
authors.lastname: Breederveld
authors.forename: L J
authors.initials: LJ
authors.lastname: Sjamsjoedin-Visser
authors.forename: M
authors.initials: M
authors.lastname: Roos
authors.forename: M
authors.initials: M
authors.lastname: Bakker
authors.forename: J
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D000386:AIDS-Related Complex / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D015331:Cohort Studies; D005500:Follow-Up Studies; D015488:HIV Antigens / Q000032:analysis; D006679:HIV Seropositivity / Q000453:epidemiology; D015497:HIV-1 / Q000276:immunology; D006467:Hemophilia A / Q000150:complications*; D006716:Homosexuality; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009426:Netherlands; D065227:Transfusion Reaction
chemical_list: D015488:HIV Antigens