Selectivity of excitotoxic mechanisms in Alzheimer's disease.
Dysfunction of glutamatergic neurons in Alzheimer's disease may actually participate in some of the neurodegenerative processes via potential excitotoxic mechanisms. Two hypotheses are advanced which describe how a generalized excitotoxic mechanism could interact with unique metabolic properties of specific cell types leading to their selective vulnerability in Alzheimer's disease.
May
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PC
Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
D000544:Alzheimer Disease / Q000378:metabolism*; D004734:Energy Metabolism; D005971:Glutamates / Q000378:metabolism / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D010101:Oxygen Consumption; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D005971:Glutamates; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid