[Effects of zinc sulfate on isolated vascular smooth muscles].
ZnSO4 was found to inhibit the contractions of isolated guinea pig aortic preparations induced by KCl, CaCl2 and noradrenaline (NE). ZnSO4 (0.01-0.1 mmol/L) shifted the dose-response curves for KCl, CaCl2 and NE to the right, and depressed their maximal responses with PD2' values of 3.21, 3.07 and 2.91 respectively. ZnSO4 (0.1 mmol/L) significantly antagonized KCl, CaCl2 and NE-induced contraction responses in isolated dog portal vein preparations. These results suggest that the ZnSO4 induced relaxation of vascular smooth muscle might result from its antagonistic effect on transmembrane Ca2+ channels.
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D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D015220:Calcium Channels / Q000187:drug effects; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011169:Portal Vein / Q000187:drug effects; D013431:Sulfates / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*; D019287:Zinc Sulfate
D015220:Calcium Channels; D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc