Transient increase of NMDA-binding sites in human hippocampus during development.
In the human hippocampus, the density of glutamate and N-methyl-D-aspartate (NMDA) binding sites follows during development a bell-shaped curve with a peak at 23-27 fetal weeks. We suggest that there is a transient increased density of NMDA binding sites during a restricted period of hippocampal development; this may play an important role in developmental plasticity.
Represa
A
A
Inserm U29, Hôpital de Port Royal, Paris, France.
Tremblay
E
E
Ben-Ari
Y
Y
D000328:Adult; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000378:metabolism; D016318:Quisqualic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism* / Q000502:physiology
D005971:Glutamates; D010069:Oxadiazoles; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid