Cross-neutralizing and subclass characteristics of antibody from horses with equine infectious anemia virus.
Antibody responses in horses with equine infectious anemia virus (EIAV) were examined to determine their cross-neutralizing capacity. Antibodies induced by infection with any of six biologically cloned variants of EIAV cross-neutralized multiple variants from the group. Anti-EIAV antibody was found in both the IgG and IgG(T) subclasses in plasmas with virus-neutralizing activity and the majority of antiviral antibody was of the IgG(T) subclass. Depletion of IgG(T) did not increase the neutralization indexes of either neutralizing or non-neutralizing plasma samples.
O'Rourke
K I
KI
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
Perryman
L E
LE
McGuire
T C
TC
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000145:classification / Q000276:immunology*; D003429:Cross Reactions; D004859:Equine Infectious Anemia / Q000276:immunology*; D006736:Horses; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D004860:Infectious Anemia Virus, Equine / Q000276:immunology*; D009500:Neutralization Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G