title: Immunological alterations inducible by mercury compounds. III. H-2A acts as an immune response and H-2E as an immune "suppression" locus for HgCl2-induced antinucleolar autoantibodies.
abstract: In responder mouse strains repeated injections of subtoxic doses of HgCl2 induce formation of antinuclear autoantibodies (ANA) and antinucleolar autoantibodies (ANolA). Others have shown that responsiveness to HgCl2-induced formation of ANA and ANolA is linked to H-2. Here, we extend these studies to a variety of mouse strains not tested previously. After confirming that strain B10.S (H-2s) is a high responder we have shown that strains B10.D2 (H-2d) and B10.BR (H-2k) are nonresponders. By comparing a panel of strains carrying appropriate intra-H-2 recombinant haplotypes derived from d, k and s, we were able to map responsiveness to As. Interestingly, among four strains all of which were As, and thus responsive, only the two H-2E- ones, B10.S and B10.RSD2, were high responders whereas the two H-2E+ ones, B10.HTT and B10.S(9R), were significantly less responsive. Thus, the genetics of HgCl2-induced autoantibody formation follow the rules established for immune responses to a variety of different antigens in that expression of H-2E "suppressed" the response.
authors.affiliation: Division of Immunology, Heinrich-Heine-University Düsseldorf, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Mirtcheva
authors.forename: C
authors.initials: C
authors.lastname: Pfeiffer
authors.forename: J A
authors.initials: JA
authors.lastname: De Bruijn
authors.forename: F
authors.initials: F
authors.lastname: Jacquesmart
authors.forename: E
authors.initials: E
authors.lastname: Gleichmann
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D002466:Cell Nucleolus / Q000276:immunology; D005802:Genes, MHC Class II; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000502:physiology*; D008628:Mercury / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000974:Antibodies, Antinuclear; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D008628:Mercury