Low levels of mumps virus antigen induced interferon-alpha production in insulin-dependent diabetes.
The in vitro production of interferon-alpha was studied in cultures of peripheral blood mononuclear cells from children with insulin-dependent diabetes. Significantly lower levels (p less than 0.01) of interferon (median 64 IU/ml) were found in mumps antigen stimulated cultures of IDDM patients compared to control children (median 256 IU/ml) whereas no differences between groups were found in the amount of interferon induced by Coxsackie B pool antigen or live Sendai virus.
Ilonen
J
J
National Public Health Institute, University of Oulu, Finland.
Salonen
R
R
Salmi
A
A
Mustonen
A
A
D000956:Antigens, Viral / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology; D005260:Female; D006801:Humans; D007369:Interferon Inducers; D007370:Interferon Type I / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D009000:Monocytes / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology*; D012016:Reference Values
D000956:Antigens, Viral; D007369:Interferon Inducers; D007370:Interferon Type I