title: Mapping of the human complement factor I gene to 4q25.
abstract: A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.
authors.affiliation: Department of Pediatrics, University of Iowa, Iowa City 52242.
authors.forename: R
authors.initials: R
authors.lastname: Shiang
authors.forename: J C
authors.initials: JC
authors.lastname: Murray
authors.forename: C C
authors.initials: CC
authors.lastname: Morton
authors.forename: K H
authors.initials: KH
authors.lastname: Buetow
authors.forename: J J
authors.initials: JJ
authors.lastname: Wasmuth
authors.forename: A H
authors.initials: AH
authors.lastname: Olney
authors.forename: W G
authors.initials: WG
authors.lastname: Sanger
authors.forename: G
authors.initials: G
authors.lastname: Goldberger
mesh_terms: D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D017244:Complement Factor I; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D012697:Serine Endopeptidases; D017244:Complement Factor I