Association of Epstein-Barr virus with an angioimmunoblastic lymphadenopathy-like lymphoproliferative syndrome.
A patient presented with fever, night sweats, generalized lymphadenopathy, cold agglutinin hemolytic anemia, and thrombocytopenia. Lymph node biopsy revealed a lymphoplasmacytic infiltrate sparing the cortical sinuses but associated with arborizing blood vessels. Epstein-Barr virus (EBV) DNA was demonstrated in tissue from an involved lymph node. These data suggest an association of EBV with a lymphoproliferative process that resembles angioimmunoblastic lymphadenopathy with dysproteinemia.
White
A C
AC
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
Katz
B Z
BZ
Silbert
J A
JA
D000956:Antigens, Viral; D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology*; D015139:Blotting, Southern; D036022:Capsid Proteins; D004279:DNA, Viral / Q000032:analysis*; D019309:Epstein-Barr Virus Nuclear Antigens; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000276:immunology / Q000382:microbiology*; D008198:Lymph Nodes / Q000276:immunology / Q000382:microbiology*; D008297:Male; D008875:Middle Aged
D000956:Antigens, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; C033305:Epstein-Barr virus early antigen