title: Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle.
abstract: Complementary DNAs for the beta subunit of the dihydropyridine-sensitive calcium channel of rabbit skeletal muscle were isolated on the basis of peptide sequences derived from the purified protein. The deduced primary structure is without homology to other known protein sequences and is consistent with the beta subunit being a peripheral membrane protein associated with the cytoplasmic aspect of the sarcolemma. The protein contains sites that might be expected to be preferentially phosphorylated by protein kinase C and guanosine 3',5'-monophosphate-dependent protein kinase. A messenger RNA for this protein appears to be expressed in brain.
authors.affiliation: Institut für Physiologische Chemie, Medizinische Fakultät, Homburg/Saar, Federal Republic of Germany.
authors.forename: P
authors.initials: P
authors.lastname: Ruth
authors.forename: A
authors.initials: A
authors.lastname: Röhrkasten
authors.forename: M
authors.initials: M
authors.lastname: Biel
authors.forename: E
authors.initials: E
authors.lastname: Bosse
authors.forename: S
authors.initials: S
authors.lastname: Regulla
authors.forename: H E
authors.initials: HE
authors.lastname: Meyer
authors.forename: V
authors.initials: V
authors.lastname: Flockerzi
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002121:Calcium Channel Blockers / Q000378:metabolism* / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D004095:Dihydropyridines / Q000378:metabolism* / Q000494:pharmacology; D008969:Molecular Sequence Data; D009132:Muscles / Q000032:analysis*; D010766:Phosphorylation; D011487:Protein Conformation; D012333:RNA, Messenger / Q000302:isolation & purification; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D012333:RNA, Messenger; D011978:Receptors, Nicotinic