Further antigenic characterization of porcine rotavirus YM.
We recently reported that the serotype specificity of YM, a group A porcine rotavirus, is different from those of the previously established rotavirus serotypes, 1 to 6 (A. M. Ruiz, I. V. Lopez, S. Lopez, R. T. Espejo, and C. F. Arias, J. Virol. 62:4331-4336, 1988). Here we demonstrate by cross-neutralization studies that rotavirus YM is also antigenically distinct from prototype rotavirus strains of serotypes 7 (Ty1), 8 (69M), 9 (WI61), and 10 (B223). A comparison of the serotype-determining amino acid regions of the YM surface glycoprotein, VP7, with the reported homologous sequences of rotavirus strains Gottfried, 69M, B37, F45, and WI61 further supported the serotypic individuality of the rotavirus YM VP7 protein.
Arias
C F
CF
Departamento de Biología Molecular, Universidad Nacional Autónoma de México, Morelos.
Ruiz
A M
AM
López
S
S
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D003429:Cross Reactions; D008562:Membrane Glycoproteins / Q000032:analysis; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D012330:RNA, Double-Stranded / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012401:Rotavirus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D012703:Serotyping; D013552:Swine
D000956:Antigens, Viral; D008562:Membrane Glycoproteins; D012330:RNA, Double-Stranded; D012367:RNA, Viral