Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures.
Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.
Gandolfo
G
G
Laboratoire de Psychophysiologie, Faculté des Sciences et Techniques, Nice, France.
Gottesmann
C
C
Bidard
J N
JN
Lazdunski
M
M
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D004546:Elapid Venoms / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D015221:Potassium Channels / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D000631:Aminopyridines; D004546:Elapid Venoms; D009498:Neurotoxins; D010455:Peptides; D015221:Potassium Channels; C008331:mast cell degranulating peptide; C020273:dendrotoxin; D015761:4-Aminopyridine