Acceleration of a murine T-cell leukemia associated with loss of interleukin-3 producing activity.
L-8313 is a murine T-cell leukemia cell line the cells of which constitutively produce interleukin-3 (IL-3). S2-8313 is a unique subline of L-8313 which has lost IL-3 producing activity. Although the growth of S2-8313 cells in the bone marrow is comparable to that of L-8313 cells, the survival time of C3H mice grafted with S2-8313 cells is significantly shorter than that of C3H mice grafted with L-8313 cells. The accelerated death observed in C3H mice bearing S2-8313 cells is attributable to early development of granulocytopenia and thrombocytopenia, which resulted from the loss of the IL-3 producing activity.
Kuriu
A
A
Division of Cancer Pathology, Osaka University Medical School, Japan.
Fujita
J
J
Kanakura
Y
Y
Yonezawa
T
T
Yoshida
K
K
Kitamura
Y
Y
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002460:Cell Line; D007377:Interleukin-3 / Q000096:biosynthesis*; D015458:Leukemia, T-Cell / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D018800:Thy-1 Antigens; D013997:Time Factors
D000954:Antigens, Surface; D007377:Interleukin-3; D018800:Thy-1 Antigens