Catecholaminergic and muscarinergic receptors in chronic experimental uremia.
In chronic uremic rats the density of alpha 1- and alpha 2-adrenoceptors in the cerebral cortex was significantly increased while beta-adrenoceptors and muscarinergic receptors in heart and brain as well as cardiac alpha 1-adrenoceptors were unchanged. Only the binding of the alpha 2-selective ligand 3H-clonidine was inhibited by uremic serum. In isolated left ventricular muscle strips dose-effect curves of (-)-noradrenaline and (+/-)-dobutamine were not significantly different in uremic and control animals whereas the negative inotropic action of the muscarinergic agonist carbachol was attenuated.
Lübbecke
F
F
Medizinische Klinik II, Giessen, FRG.
Steudle
V
V
Schütterle
G
G
Wizemann
V
V
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002395:Catecholamines / Q000493:pharmacokinetics; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D017983:Receptors, Catecholamine; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism; D014508:Urea / Q000097:blood; D014511:Uremia / Q000503:physiopathology*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D011976:Receptors, Muscarinic; D014508:Urea