title: Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?
abstract: Metabolic interaction between naloxone and morphine has been studied in vitro in human liver microsomes. Morphine and naloxone are metabolized by an UDP-glucuronyl transferase to their 3-glucuronides. There is a very good correlation between the rates of formation of morphine-3-glucuronide and of naloxone-3-glucuronide. Naloxone seems to have a 10-fold higher affinity for the enzyme binding site than does morphine. Morphine and naloxone show bisubstrate kinetic patterns which appear very similar.
authors.affiliation: Division of Clinical Pharmacology, University Hospital, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wahlström
authors.forename: K
authors.initials: K
authors.lastname: Persson
authors.forename: A
authors.initials: A
authors.lastname: Rane
mesh_terms: D002851:Chromatography, High Pressure Liquid; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009020:Morphine / Q000378:metabolism*; D009270:Naloxone / Q000378:metabolism*; D014535:Uridine Diphosphate Glucuronic Acid / Q000378:metabolism
chemical_list: D014535:Uridine Diphosphate Glucuronic Acid; D009270:Naloxone; D009020:Morphine; D014453:Glucuronosyltransferase