title: Hypoxic-reperfusion injury in the inflamed human joint.
abstract: A series of experiments showed that, on exercise of the inflamed human knee, intra-articular pressure rises above synovial capillary perfusion pressure, causing intra-articular hypoxia; and that, on cessation of exercise, there is oxidative damage to lipids and IgG within the joint. These findings are consistent with the hypothesis that persistence of synovial inflammation can be due to exercise-induced hypoxic-reperfusion injury mediated by reactive oxygen species.
authors.affiliation: Inflammation Group, London Hospital Medical College.
authors.forename: D R
authors.initials: DR
authors.lastname: Blake
authors.forename: P
authors.initials: P
authors.lastname: Merry
authors.forename: J
authors.initials: J
authors.lastname: Unsworth
authors.forename: B L
authors.initials: BL
authors.lastname: Kidd
authors.forename: J M
authors.initials: JM
authors.lastname: Outhwaite
authors.forename: R
authors.initials: R
authors.lastname: Ballard
authors.forename: C J
authors.initials: CJ
authors.lastname: Morris
authors.forename: L
authors.initials: L
authors.lastname: Gray
authors.forename: J
authors.initials: J
authors.lastname: Lunec
mesh_terms: D000328:Adult; D000368:Aged; D015444:Exercise; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D007074:Immunoglobulin G / Q000032:analysis; D007719:Knee Joint; D015227:Lipid Peroxidation; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011312:Pressure; D015427:Reperfusion Injury / Q000209:etiology*; D013582:Synovial Fluid / Q000032:analysis; D013583:Synovial Membrane / Q000098:blood supply; D013585:Synovitis / Q000503:physiopathology*
chemical_list: D007074:Immunoglobulin G