title: Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor.
abstract: Gamma irradiation of a human cell line containing an extrachromosomal plasmid results in inhibition of the replication of both genomic and plasmid DNA. This inhibition is observed at doses of radiation which produce an insignificant amount of damage in the plasmid DNA molecules. These results indicate that radiation-induced inhibition of DNA replication is mediated by a trans-acting factor.
authors.affiliation: MRC Cell Mutation Unit, Sussex University, Brighton, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Lamb
authors.forename: C
authors.initials: C
authors.lastname: Petit-Frère
authors.forename: B C
authors.initials: BC
authors.lastname: Broughton
authors.forename: A R
authors.initials: AR
authors.lastname: Lehmann
authors.forename: M H
authors.initials: MH
authors.lastname: Green
mesh_terms: D002460:Cell Line; D004249:DNA Damage; D004261:DNA Replication / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D010957:Plasmids / Q000528:radiation effects