[Activation of the interferon system enzymes by recombinant alpha2-interferon in patients with chronic hepatitis B].
Treatment of patients suffering from chronic hepatitis B with recombinant leukocytic interferon (reaferon) increased the levels of circulating interferon and activated interferon-dependent enzymes such as 2-5A-synthetase and histone kinase. Activation of the enzymes was observed for 1 to 2 weeks. After that period it was maintained at the required levels with intramuscular administration of 1-3 million units of reaferon 2 or 3 times a week. In parallel with increasing of the levels of the interferon system enzymes there was observed a decrease in the level of aminotransferase. The reaction of the viral antigens to the treatment with reaferon was not the same: HBe antigen and antibodies to HBe antigen disappeared, the content of HBs antigen and antibodies to delta-interferon did not change.
Sokolova
T M
TM
Bugaeva
N P
NP
Suetina
I A
IA
Ershov
F I
FI
Ketiladze
E S
ES
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D002908:Chronic Disease; D004789:Enzyme Activation; D006509:Hepatitis B / Q000201:enzymology / Q000628:therapy*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006513:Hepatitis B e Antigens / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D006656:Protamine Kinase / Q000378:metabolism; D011994:Recombinant Proteins
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D006656:Protamine Kinase; D015088:2',5'-Oligoadenylate Synthetase
Aktivatsiia rekombinantnym alpha2-interferonom fermentov sistemy interferona u bol'nykh khronicheskim gepatitom B.