[Effects of nifedipine and verapamil on cysteinyl leukotriene-induced contractions of the sheep uterus].
Both nifedipine and verapamil, the calcium channel blockers were tested to determine their anti-leukotriene properties in pig uterine strips. These drugs in concentrations ranging from 1.10(-7)M to 1.10(-5)M significantly attenuated the constrictor effects of cysteinyl leukotrienes in pig uterus. Thus, leukotrienes C4, D4 and E4 are dependent upon Ca2+ for their myotropic activity, an action non-competitively inhibited by the calcium channel blockers nifedipine and verapamil.
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Zakład Patofizjologii Wydziału Weterynaryjnego Akademii Rolniczej w Lublinie.
Kadziołka
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D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D017999:Leukotriene E4; D009543:Nifedipine / Q000494:pharmacology*; D013189:SRS-A / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology*
D013189:SRS-A; D017999:Leukotriene E4; D014700:Verapamil; D009543:Nifedipine
Wpływ nifedipiny i verapamilu na skurczowe działanie leukotrienów cysteinylowych na macice świni.