Kappa-opioid agonists do not inhibit adenylate cyclase.
Morphine, levorphanol and D-Ala2, Met enkephalin, but not bremazocine, pentazocine, U-50 488H and U-69 593, were found to inhibit adenylate cyclase activity dose-dependently in bullfrog brain membranes. The inhibition of the enzyme activity was abolished by naloxone. These results suggest that the signalling transduction of mu- and delta-agonists is partially mediated by the adenylate cyclase system coupled with opioid receptors, but that kappa-receptors may not be associated with adenylate cyclase.
Makimura
M
M
Department of Pharmacy, College of Science and Technology, Nihon University, Tokyo, Japan.
Murakoshi
Y
Y
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D044482:Benzeneacetamides; D001575:Benzomorphans / Q000494:pharmacology; D001667:Binding, Competitive; D001921:Brain / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007981:Levorphanol / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000378:metabolism; D010423:Pentazocine / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D011892:Rana catesbeiana; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D012965:Sodium Chloride / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D044482:Benzeneacetamides; D001575:Benzomorphans; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D007981:Levorphanol; D006165:Guanylyl Imidodiphosphate; D009270:Naloxone; D012965:Sodium Chloride; D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D009020:Morphine; D006160:Guanosine Triphosphate; C027248:bremazocine; C045444:U 69593; D010423:Pentazocine