Predilection of a nasopharyngeal carcinoma-derived isolate of Epstein-Barr virus for infection of specific subsets of B lymphocytes.
It is important to know whether there are variants of Epstein-Barr virus (EBV) with biological properties that are different from the prototype viruses that have been studied in detail, such as P3HR-1 and B95-8. We have studied an EBV isolate derived from a nasopharyngeal carcinoma (NPC) tumor, designated NPC-EBV. We have examined the target B lymphocytes infected and growth-transformed with NPC-EBV as compared with two common EBV isolates, B95-8 and AG876 EBV, for stage of maturation using antibodies to several immunoglobulin chains. Typing of the NPC-EBV transformed lymphoblastoid cell lines revealed the predilection of the NPC-EBV isolate to infect immature B lymphocytes. This was not the case for the B95-8 and AG876 isolates. The reason for the predilection of NPC-EBV for immature B lymphocytes remains to be explored further. However, these results may be important in understanding the pathophysiology of EBV-associated diseases.
Tarr
K L
KL
Department of Medical Microbiology and Immunology, College of Medicine, Ohio State University, Columbus 43210.
Glaser
R
R
D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000382:microbiology*; D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007128:Immunoglobulin Fragments / Q000032:analysis*; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology; D011951:Receptors, Complement / Q000032:analysis*; D017464:Receptors, Complement 3d
D000944:Antigens, Differentiation, B-Lymphocyte; D007128:Immunoglobulin Fragments; D011951:Receptors, Complement; D017464:Receptors, Complement 3d