[Sigma receptors of the loach embryo regulate ornithine decarboxylase activity].
When loach embryos (Miagurnus fossilis) were incubated with opioid substance, sigma-receptors ligand SKF 10.047, activity of the key enzyme of polyamine synthesis - ornithine decarboxylase (ODC), increased. A correlation between teratogenic and ODC-stimulated action of SKF 10.047 was stage-specific and depend on opioid concentration. Possible mechanism of embryonic cell aggregation under SKF 10.047 action and polyamines role in that process is discussed.
Kaliuzhnyĭ
A E
AE
Iarygin
K N
KN
Sukhikh
G T
GT
D000818:Animals; D002449:Cell Aggregation; D003531:Cypriniformes / Q000196:embryology / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000201:enzymology; D066298:In Vitro Techniques; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism; D011957:Receptors, Opioid / Q000502:physiology*; D017480:Receptors, sigma
D011073:Polyamines; D011957:Receptors, Opioid; D017480:Receptors, sigma; C012134:SK&F 10047; D009955:Ornithine Decarboxylase; D010620:Phenazocine
Sigma-retseptory zarodysheĭ v'iuna reguliruiut aktivnost' ornitindekarboksilazy.