A theoretical study of the acidification of the rhinovirus capsid.
Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a beta-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none.
Warwicker
J
J
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.
D002213:Capsid / Q000502:physiology*; D006639:Histidine; D006863:Hydrogen-Ion Concentration; D007526:Isoelectric Point; D008574:Mengovirus / Q000502:physiology; D008958:Models, Molecular; D011487:Protein Conformation; D012229:Rhinovirus / Q000502:physiology* / Q000648:ultrastructure; D013329:Structure-Activity Relationship
D006639:Histidine