Human cytochrome c oxidase during cardiac growth and development.
Human heart mitochondrial cytochrome c oxidase specific content and specific activity was measured in five fetuses 15-21 weeks gestational age and in five patients whose age ranged from 6 days to 22 years. None had evidence of cardiac pathology. An increase in cytochrome c oxidase specific content and specific activity was observed in the fetal heart with increasing gestational age (0.13-0.38 nmol heme a/mg protein and 67-295 nmol O2 utilized/min/mg protein) and from the neonatal period (0.35 nmol heme a/mg protein and 140 nmol O2/min/mg protein) to adulthood (1.2 nmol heme a/mg protein and 1104 nmol O2/min/mg protein). A marked increase was observed postnatally between 4 and 19 months.
Marin-Garcia
J
J
Pediatric Cardiology/Department of Pediatrics, UMDNJ-New Jersey Medical School, Newark.
Baskin
L S
LS
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005318:Fetal Heart / Q000201:enzymology* / Q000254:growth & development; D006321:Heart / Q000254:growth & development*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008929:Mitochondria, Heart / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*
D003576:Electron Transport Complex IV