Loss of calcitonin receptors: a genetically transmitted defect in rats with high incidence of C-cell tumors.
C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.
Bouizar
Z
Z
UA 163 CNRS and U.113 INSERM, CHU Saint-Antoine, Paris, France.
Minvielle
S
S
Treilhou-Lahille
F
F
Rostene
W H
WH
Pidoux
E
E
Feingold
N
N
Milhaud
G
G
Moukhtar
M S
MS
D000375:Aging; D000818:Animals; D001345:Autoradiography; D002116:Calcitonin / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D002872:Chromosome Deletion; D003433:Crosses, Genetic; D005796:Genes; D007457:Iodine Radioisotopes; D007679:Kidney Medulla / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface / Q000032:analysis / Q000235:genetics*; D013045:Species Specificity; D013961:Thyroid Gland / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000235:genetics*
D007457:Iodine Radioisotopes; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface; D002116:Calcitonin; D002118:Calcium