AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis.
Kaposi's sarcoma is a mesenchymal tumor that is frequently observed in AIDS patients. Although the tumor is clearly associated with HIV-1 infection, little is known about the molecular events underlying its pathogenesis. Here we consider the potential roles of specific cytokines and the virally encoded tat product in inducing the tumor.
Ensoli
B
B
Laboratory of Tumor Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892.
Salahuddin
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SZ
Gallo
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RC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000235:genetics; D015696:Gene Products, tat; D006133:Growth Substances / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000235:genetics; D015534:Trans-Activators; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D006133:Growth Substances; D015534:Trans-Activators; D054322:tat Gene Products, Human Immunodeficiency Virus