Effects of dietary eicosapentaenoate (20:5 n-3) on cardiac beta-adrenergic receptor activity in the marmoset monkey.
Eicosapentaenoic acid (EPA; 20:5 n-3; ethyl ester) in combination with atherogenic or non-atherogenic high fat diets was fed to young adult male marmoset monkeys for a period of 30 weeks. EPA markedly reduced the raised plasma cholesterol level evident when feeding an atherogenic diet but did not influence the cardiac membrane cholesterol-to-phospholipid ratio. EPA and its elongation product 22:5 n-3 was incorporated into cardiac membrane phospholipids at the expense of linoleic and arachidonic acids. Dietary EPA increased cardiac beta-AR affinity and reversed the decreased beta-AR affinity evident when feeding an atherogenic diet.
Patten
G S
GS
CSIRO, Division of Human Nutrition, Glenthorne Laboratory, Australia.
Rinaldi
J A
JA
McMurchie
E J
EJ
D000818:Animals; D002144:Callithrix; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D020120:Iodocyanopindolol; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D010743:Phospholipids / Q000378:metabolism; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*
D004041:Dietary Fats; D008563:Membrane Lipids; D010743:Phospholipids; D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D002784:Cholesterol; D011433:Propranolol; D015118:Eicosapentaenoic Acid; D010869:Pindolol