[The effect of the ACTH(4-10) fragment on certain forms of adaptive behavior in mice of various genetic groups].
CBA/Lac/Sto mice, C57/BL/6J mice and random bred mice with robertsonian translocation of chromosomes 8 and 17 (T1IEM mice) were compared under normal conditions and after ACTH4-10 injections. The rate of food procuring learning in U-shaped maze and in radial 5-arm maze was studied, and the ability of mice to extrapolate the direction of stimulus movement. Peptide i. p. injections (40 mkg/kg) stimulated the learning in U-shaped maze in all genotypes. T1IEM mice demonstrated better radial arm maze performance than CBA. Peptide injections tended to improve it in the former and to impair in the latter genotype. T1IEM mice demonstrated the ability for extrapolation, while CBA mice revealed no such ability. ACTH4-10 injections improved problem solving only in T1IEM mice. Cases when animals "refused" to participate in the experiment, were significantly rare in groups of all genotypes under peptide treatment.
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D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice / Q000235:genetics / Q000502:physiology*; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000494:pharmacology*; D014178:Translocation, Genetic / Q000235:genetics / Q000502:physiology
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)
Vliianie fragmenta AKTG4-10 na nekotorye formy adaptivnogo povedeniia mysheĭ raznykh geneticheskikh grupp.