[The pharmacology of 1-(2-pyrimidinyl)piperazine, a metabolite of buspirone].
In experiments on rats the anxiolytic activity of 1-(2-pyrimidinyl)-piperazine (PP) was revealed only in some models of anxiety states, although diazepam was effective in all used models. In contrast to diazepam, PP exerts the anesthetic-potentiating and myorelaxant effects only when administered in subtoxic doses and possesses no anticorazole activity. The facts testifying to the serotoninergic mechanisms of the anxiolytic action of 1-(2-pyrimidinyl)-piperazine are presented.
Komissarov
I V
IV
Dulenko
V I
VI
Kharin
N A
NA
Tolkunov
S V
SV
Talalaenko
A N
AN
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D002065:Buspirone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D051379:Mice; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats
D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; C037921:1-(2-pyrimidinyl)piperazine; D003975:Diazepam; D002065:Buspirone
Farmakologiia 1-(2-pirimidinil)-piperazina, metabolita buspirona.