title: Functional heterogeneity of CD4+ T cells in leishmaniasis.
abstract: In this article F.Y. Liew summarizes the evidence for the functional heterogeneity of CD4+ T cells from studies of immune regulation in the parasitic disease, leishmaniasis. Recent findings suggest that the heterogeneity of CD4+ T cells may extend beyond the current Th1 and Th2 classification and that these T-cell subsets manifest some of their functions via the lymphokines they secrete, and that the balance of these determines the outcome of the infection.
authors.forename: F Y
authors.initials: FY
authors.lastname: Liew
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000145:classification* / Q000276:immunology / Q000637:transplantation; D004198:Disease Susceptibility; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007891:Leishmania / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D014611:Vaccination
chemical_list: D000913:Antibodies, Protozoan