The murine Il-6 gene maps to the proximal region of chromosome 5.
Murine Il-6 cDNAs were isolated by cross-hybridization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.
Mock
B A
BA
Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892.
Nordan
R P
RP
Justice
M J
MJ
Kozak
C
C
Jenkins
N A
NA
Copeland
N G
NG
Clark
S C
SC
Wong
G G
GG
Rudikoff
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D004247:DNA / Q000302:isolation & purification; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D015850:Interleukin-6; D007378:Interleukins / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D015850:Interleukin-6; D007378:Interleukins; D004247:DNA