title: Biologically active conformation of [Met5]- and [Leu5]enkephalin on delta opioid receptor.
abstract: Investigations of the conformation of endogenous enkephalins are generally based on structural comparisons of enkephalins with other opiates and on experimental pharmacological studies. Based on such investigations, we now propose a novel model of the biologically active (receptor-bound) conformation of [Met5]- and [Leu5]enkephalin on the delta opioid receptor. The model helps with the design of new opioid analgesics.
authors.affiliation: Institute of Health, Bratislava, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Gasparík
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004743:Enkephalin, Leucine / Q000378:metabolism / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000378:metabolism / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000187:drug effects; D010649:Phenylalanine / Q000378:metabolism; D011487:Protein Conformation; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta
chemical_list: D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D010649:Phenylalanine; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine