Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine.
The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.
Foster
P S
PS
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra A.C.T.
Gesini
E
E
Claudianos
C
C
Hopkinson
K C
KC
Denborough
M A
MA
D000818:Animals; D002118:Calcium / Q000032:analysis*; D006221:Halothane / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000032:analysis*; D008305:Malignant Hyperthermia / Q000201:enzymology*; D008722:Methods; D009119:Muscle Contraction / Q000187:drug effects; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000172:deficiency*; D010766:Phosphorylation; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D013403:Sugar Phosphates / Q000032:analysis*; D013552:Swine
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D015544:Inositol 1,4,5-Trisphosphate; D010744:Phosphoric Monoester Hydrolases; C043422:myo-inositol 1,4,5-triphosphate phosphatase; D002118:Calcium; D006221:Halothane