title: Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs.
abstract: The effects of the enantiomers of 11-hydroxy-delta 8-tetrahydrocannabinol-dimethylheptyl (11-OH-delta 8-THC-DMH) on spontaneous activity, rectal temperature, tail-flick latency, and catalepsy were studied in mice and in the dog static-ataxia model to determine the relative potency of each enantiomer. The (-)-enantiomer was active in all tests between 3-100 micrograms/kg, while the (+)-enantiomer was inactive at 30 mg/kg in the mouse and 1 mg/kg in the dog. The (-)-enantiomer was 100-800 times more potent than delta 9-THC in the mouse. The high degree of enantioselectivity and potency are suggestive of an interaction at a specific site such as a receptor.
authors.affiliation: Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
authors.forename: P J
authors.initials: PJ
authors.lastname: Little
authors.forename: D R
authors.initials: DR
authors.lastname: Compton
authors.forename: R
authors.initials: R
authors.lastname: Mechoulam
authors.forename: B R
authors.initials: BR
authors.lastname: Martin
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced*; D004285:Dogs; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: C020367:11-hydroxy-delta(8)-tetrahydrocannabinol; D013759:Dronabinol