title: Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.
abstract: Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27701.
authors.forename: S
authors.initials: S
authors.lastname: Ram
authors.forename: L D
authors.initials: LD
authors.lastname: Spicer
mesh_terms: D002245:Carbon Dioxide; D002250:Carbon Radioisotopes; D002746:Chlorpromazine / Q000138:chemical synthesis*; D006801:Humans; D007553:Isotope Labeling
chemical_list: D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D002746:Chlorpromazine