Variations in red blood cell polyamines in brain tumour patients treated with stereotactic radiosurgery.
Red blood cell polyamine levels were followed in 13 patients treated with stereotactic radiosurgery for various types of brain tumours. In the most malignant tumours radiosurgery resulted in a decrease in spermine and an increase in spermidine levels. This discrepancy between variations in polyamine levels was not found after conventional radiotherapy. The results may indicate a change in tumour polyamine activity induced by high energy radiotherapy.
von Essen
C
C
Department of Neurosurgery, University of Birmingham, Warley, West Midlands, UK.
Elworthy
P
P
Hitchcock
E
E
D000236:Adenoma / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D003397:Craniopharyngioma / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D010911:Pituitary Neoplasms / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D011073:Polyamines / Q000097:blood*; D013238:Stereotaxic Techniques; D013997:Time Factors
D011073:Polyamines