Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.
We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression.
Clurman
B E
BE
Sloan-Kettering Institute for Cancer Research, New York, New York 10021.
Hayward
W S
WS
D000818:Animals; D001353:Avian Leukosis / Q000235:genetics; D001354:Avian Leukosis Virus / Q000235:genetics / Q000502:physiology*; D001402:B-Lymphocytes / Q000382:microbiology; D002642:Chick Embryo; D002645:Chickens; D003001:Cloning, Molecular; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000382:microbiology; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D012334:RNA, Neoplasm / Q000235:genetics; D015183:Restriction Mapping
D015342:DNA Probes; D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm