Cellular immunity in chicks expressing fibrosarcomatous liver tumor following embryo infection with subgroup A Rous sarcoma virus.
Bryan standard strain of Rous sarcoma virus (BS-RSV) of subgroup A was inoculated into heavy and light breeds of chicken embryos via chorioallantoic membrane (CAM) to ascertain cell-mediated immune response, as measured by a leukocyte migration inhibition (LMI) test. Chicks hatched from eggs with pock-positive CAMs were more likely to develop liver tumors than those hatched from eggs with pock-negative CAMs. Chicks that developed tumors usually had a positive cell-mediated immune response, and those that were negative for liver tumor were negative, based on the LMI test.
Pani
P K
PK
Indian Veterinary Research Institute, Uttar Pradesh.
Kishore
S
S
Naithani
S
S
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001358:Avian Sarcoma Viruses / Q000302:isolation & purification; D002464:Cell Migration Inhibition; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology*; D005354:Fibrosarcoma / Q000276:immunology*; D007111:Immunity, Cellular; D008113:Liver Neoplasms / Q000032:analysis / Q000276:immunology*; D010641:Phenotype; D013045:Species Specificity
D000951:Antigens, Neoplasm