Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice.
The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.
Nagata
Y
Y
Department of Biochemistry, Sapporo Medical College, Japan.
Konno
R
R
Yasumura
Y
Y
Akino
T
T
D000596:Amino Acids / Q000032:analysis* / Q000652:urine; D000818:Animals; D003605:D-Amino-Acid Oxidase / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains
D000596:Amino Acids; D003605:D-Amino-Acid Oxidase