Role of the environment in the interaction of nonintercalators with Z-DNA.
Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However no definite Z to B transition in presence of these ligands was found in any case, in contrast to previously reported results (Ch. Zimmer, C. Marck and W. Guschlbauer, FEBS Lett. 154, 156-160 (1983)).
Rao
K E
KE
Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
Ramesh
N
N
Choudhury
D
D
Brahmachari
S K
SK
Sasisekharan
V
V
D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D003035:Cobalt; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000378:metabolism*; D000431:Ethanol; D006146:Guanidines / Q000378:metabolism*; D008024:Ligands; D015636:Magnesium Chloride; D008968:Molecular Conformation; D009429:Netropsin / Q000378:metabolism*; D011073:Polyamines; D011089:Polydeoxyribonucleotides; D011758:Pyrroles / Q000378:metabolism*; D012965:Sodium Chloride; D013057:Spectrum Analysis
D002712:Chlorides; D004214:Distamycins; D006146:Guanidines; D008024:Ligands; D011073:Polyamines; D011089:Polydeoxyribonucleotides; D011758:Pyrroles; D015636:Magnesium Chloride; C007936:hexaminecobalt (III) trichloride; C019530:poly(dC-dG); D003035:Cobalt; D000431:Ethanol; D012965:Sodium Chloride; D009429:Netropsin; D004247:DNA; C018021:cobaltous chloride