Iontophoretic transport of weak electrolytes through the excised human stratum corneum.
The effect of iontophoresis on the rate of permeation of a number of therapeutically active weak acids and bases through excised human stratum corneum has been examined, over a range of pH values. It has been shown that the amount of ionized drug species present in the drug solution is an important factor in the delivery of acids and bases by this route and that the molecular weight of the drug does not influence the rate of delivery by iontophoresis.
Siddiqui
O
O
School of Pharmacy, University of Tasmania, Hobart, Australia.
Roberts
M S
MS
Polack
A E
AE
D002851:Chromatography, High Pressure Liquid; D004573:Electrolytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007293:Inosine Triphosphate / Q000494:pharmacology; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010862:Pilocarpine / Q000493:pharmacokinetics; D012869:Skin Absorption
D004573:Electrolytes; D010862:Pilocarpine; D007293:Inosine Triphosphate