[Distribution of Alu repeats along the human genome: formation of clusters and features of insertion regions].
The contextual analysis of nucleotide sequences of 22 Alu repeats arrangement regions in the human genome has been carried out and some of their peculiarities have been revealed. In particular, the occurrence of marked and statistical non-random homology between the repeats and the regions of their integration has been shown. A mechanism of choosing the Alu repeats insertion regions in the genome has been suggested taking into account these peculiarities. Using a sample of the 80 human Alu repeats sequences peculiarities of these repeats location within the genome has been investigated. A tendency to the formation of Alu repeats clusters in various regions of the genome was revealed. A range of possible mechanisms on such Alu clusters emergence is considered. On the basis of the data obtained an "attraction" mechanism, according to which integration of Alu repeats into the definite region of the genome increases the insertion probability of other Alu repeats into the same region, are proposed.
Shakhmuradov
I A
IA
Kolchanov
N A
NA
Kapitonov
V V
VV
D005075:Biological Evolution; D004247:DNA / Q000235:genetics*; D004251:DNA Transposable Elements; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
D004251:DNA Transposable Elements; D004247:DNA
Rasprostranenie povtorov Alu cheloveka po genomu: formirovanie klasterov i osobennosti uchastkov vstraivaniia.