Adrenoceptors on blood cells in patients with essential hypertension before and after mental stress.
The effect of mental arithmetic (MA) on alpha 2- and beta 2-adrenoceptors on platelets and lymphocytes, respectively, and on plasma catecholamines was studied in normotensive (NT) and essential hypertensive (HT) subjects. There were no significant differences in responses of blood pressure, forearm blood flow (FBF) and heart rate to MA between the two groups. Baseline values and changes in adrenaline and noradrenaline levels during MA were similar in NT and HT. Alpha 2-adrenoceptor density and antagonist affinity did not differ between NT and HT and was not influenced by MA. Baseline values of beta 2-adrenoceptor density also did not differ between NT and HT and increased similarly after MA in both groups. Antagonist affinity to the beta 2-adrenoceptors under baseline conditions was lower in HT and did not change during MA in either group. Our results indicate that there are no differences between NT and HT in alpha 2- and beta 2-adrenoceptor density, either under baseline conditions or after mental stress.
Graafsma
S J
SJ
Department of Medicine, University of Nijmegen, The Netherlands.
van Tits
L J
LJ
van Heijst
P
P
Reyenga
J
J
Lenders
J W
JW
Rodrigues de Miranda
J F
JF
Thien
T
T
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013315:Stress, Psychological / Q000502:physiology*; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine