Effects of training on regional substrate oxidation in the hearts of ageing rats.
23-month-old male rats were trained by running for 20 weeks. The oxidation rates of succinate, glutamate+malate, palmitoylcarnitine, and pyruvate and the activities of lactate dehydrogenase, citrate synthase, isocitrate dehydrogenase and cytochrome oxidase were measured in the subendocardium and subepicardium and in the right ventricle. Regional differences of substrate oxidation rates in the myocardium of old sedentary or trained rats were less than in young rats, suggesting that regional differences in the cardiac work load disappear during ageing. Training did not improve oxidation rates, in contradiction to some previous results.
Kainulainen
H
H
Department of Cell Biology, University of Jyväskylä, Finland.
Komulainen
J
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D002950:Citrate (si)-Synthase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase