Receptors of the thyroid: the thyrotropin receptor is only the first violinist of a symphony orchestra.
A basic reason for undertaking these studies was to further our knowledge of the structure and function of the TSH receptor as well as its interaction with other receptors on thyroid cells. The multiplicity of observations suggests the approach is bearing fruit, does not provide a simple answer, and can have pitfalls. We hope they may also contribute to understanding the structure and function of autoantigens in Graves' disease and glycoprotein hormone receptors in general. The authors are grateful to their collaborators in the National Dental Institute, particularly Drs. Bellur Prabhakar, Edward Oates, and Abner Notkins, in the National Cancer Institute, Drs. W. O. McBride and M. Lerman for their contributions to the cloning studies.
Kohn
L D
LD
Section on Cell Regulation, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Saji
M
M
Akamizu
T
T
Ikuyama
S
S
Isozaki
O
O
Kohn
A D
AD
Santisteban
P
P
Chan
J Y
JY
Bellur
S
S
Rotella
C M
CM
D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000235:genetics; D001483:Base Sequence; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007454:Iodides / Q000378:metabolism; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D011989:Receptors, Thyrotropin / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism*
D001324:Autoantigens; D007328:Insulin; D007454:Iodides; D011956:Receptors, Cell Surface; D018110:Receptors, Lipoprotein; D011989:Receptors, Thyrotropin; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin