The effect of fetal irradiation on the growth of postnatally xenotransplanted tumour cells.
Exposure of the mouse fetus (NMRI-strain) to 1.0 Gy X-irradiation has a marked effect on postnatally xenotransplanted glioma cells. In comparison to non-irradiated animals, irradiation on gestation day 14 resulted in: (a) a significantly higher rate of animals which failed to develop visible tumours growing from the inoculum; (b) a significant inhibition of the growth rate of solid gliomas; (c) a pronounced granulocytic and mast cell infiltration, and tissue necrosis, in the invading gliomas. The results suggest that irradiation in prenatal life exerts an amplifying effect on the antitumour response in postnatal life.
Plendl
J
J
GSF, Institut für Pathologie, Neuherberg, F.R. Germany.
Schmahl
W
W
Heinzmann
U
U
D000818:Animals; D001254:Astrocytoma / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D009368:Neoplasm Transplantation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D014183:Transplantation, Heterologous