Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride.
1. Constitutive and ethoxyquin hydrochloride (EQ-HCl)-induced hepatic glutathione (GSH) S-transferase, GSH reductase, and GSH peroxidase activities were determined in 5 strains of 8-10 week old inbred male mice. 2. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) mumol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3-25.3 mumol product formed/min/mg protein. 3. EQ-HCl induced GST activity in all the strains examined and this contrasted to the induction activity of Aroclor 1254 which was strain-dependent. GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively.
Makary
M
M
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station 77843.
Kim
H L
HL
Safe
S
S
Womack
J
J
Ivie
G W
GW
D000818:Animals; D004790:Enzyme Induction; D005015:Ethoxyquin / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D011804:Quinolines / Q000494:pharmacology*
D011804:Quinolines; D005015:Ethoxyquin; D005982:Glutathione Transferase