title: Calcium movements during each heart beat.
abstract: Transsarcolemmal calcium movements are closely related to force generation in the heart. It is important to understand the transport pathways that control these movements of calcium across the sarcolemmal membrane. In the normal, beating heart, sodium-calcium exchange appears to be an important mechanism for the extrusion of calcium from the cell. The kinetics of this exchange are dependent upon the characteristics of the cell action potential. Calcium efflux via sodium-calcium exchange may be sufficient to balance calcium entry through calcium channels during the action potential.
authors.affiliation: University Laboratory of Physiology, Oxford, England.
authors.forename: T
authors.initials: T
authors.lastname: Powell
authors.forename: D
authors.initials: D
authors.lastname: Noble
mesh_terms: D000200:Action Potentials; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D006168:Guinea Pigs; D007474:Ion Exchange; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D012964:Sodium; D002118:Calcium