title: Group C rotavirus infections in patients with diarrhea in Thailand, Nepal, and England.
abstract: Atypical rotavirus obtained from fecal specimens of six patients with diarrhea from Thailand, Nepal, and England were characterized by using polyacrylamide gel electrophoresis and immune electron microscopy. The electropherotypes were characteristic of the porcine reference group C rotavirus strain but demonstrated considerable strain-to-strain variation. Human convalescent group C sera had a high titer (1:320) when tested against the human isolates and a low titer (1:40) when tested against a porcine reference strain (Cowden). When porcine antiserum (Cowden) was tested against the human isolates, the titers ranged from 1:40 to 1:320, indicating significant antigenic diversity between strains. Group C rotavirus appears to have a worldwide distribution as an agent associated with diarrhea in children and adults.
authors.affiliation: Division of Viral Diseases, Center for Infectious Diseases, Atlanta, Georgia 30333.
authors.forename: M E
authors.initials: ME
authors.lastname: Peñaranda
authors.forename: W D
authors.initials: WD
authors.lastname: Cubitt
authors.forename: P
authors.initials: P
authors.lastname: Sinarachatanant
authors.forename: D N
authors.initials: DN
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Likanonsakul
authors.forename: L
authors.initials: L
authors.lastname: Saif
authors.forename: R I
authors.initials: RI
authors.lastname: Glass
mesh_terms: D000328:Adult; D002648:Child; D003967:Diarrhea / Q000382:microbiology*; D004739:England; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D009390:Nepal; D012330:RNA, Double-Stranded / Q000235:genetics / Q000302:isolation & purification; D012401:Rotavirus / Q000145:classification / Q000302:isolation & purification* / Q000648:ultrastructure; D012400:Rotavirus Infections / Q000382:microbiology*; D013785:Thailand; D014481:United States / Q000208:ethnology
chemical_list: D012330:RNA, Double-Stranded