PAF-acether, superoxide anion and beta-glucuronidase as parameters of polymorphonuclear cell activation associated with cardiac surgery and cardiopulmonary bypass.
1. Seven patients submitted to myocardial revascularization surgery with cardiopulmonary bypass were studied. Blood samples were obtained immediately before and 24 h after surgery. The parameters studied were the production of platelet activating factor (PAF-acether) and superoxide anion, cellular beta-glucuronidase activity as well as polymorphonuclear cell (PMN) and platelet counts. 2. Twenty-four h after surgery, there was a 54% decrease in platelet number (P less than 0.005), a 121% increase in PMN number (P less than 0.005), a 353% increase in PAF-acether (P less than 0.01), a 211% increase in superoxide anion (O2-) and a 104% increase in beta-glucuronidase (P less than 0.05) levels when compared with the pre-surgery levels. 3. The present results indicate that PMN are more reactive after surgery with cardiopulmonary bypass.
Hoshikawa-Fujimura
A Y
AY
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Auler Júnior
J O
JO
Da Rocha
T R
TR
Brandizzi
L I
LI
Pascual
J M
JM
Chamone
D A
DA
Jatene
A D
AD
D001772:Blood Cell Count; D002315:Cardiopulmonary Bypass; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009204:Myocardial Revascularization; D009504:Neutrophils / Q000502:physiology*; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D010976:Platelet Count; D013481:Superoxides / Q000097:blood*
D010972:Platelet Activating Factor; D013481:Superoxides; D005966:Glucuronidase