[Effect of glutamic acid palmitamide or linoleamide on convulsions induced by pentetrazole].
Female Balb-C mice received glutamic acid palmitamide (PGt) or linoleamide (LGt) at doses included between 10 and 135 mg.kg-1 (i.p.) and, 90 min after these injections, pentetrazol (PTZ) at 90 mg.kg-1, i.p. PGt (10 or 100 mg.kg-1, i.p.) reduced significantly latencies of first convulsions and lethality and increased the intensity of convulsions after PTZ. This effect disappeared at 135 mg.kg-1, i.p. and, at high doses (up to 150 mg.kg-1, i.p.) PGt antagonized the PTZ convulsions. LGt (10 mg.kg-1, i.p.) had not any significant effect on the PTZ convulsions and antagonized them when administered at a dose of 100 mg.kg-1, i.p. These results, as well as them obtained with PGt and LGt on the haloperidol or reserpine catalepsy, could be the reflection of the preferential impact of LGt in the striatum and of PGt in the limbic structures and in the substantia nigra. At high doses these compounds could reach brain regions with low density of glutamatergic receptors (thalamus, reticular formation) and develop an activating effect able to antagonize the propagation of the PTZ convulsions. These preferential impacts could augur an antiepileptic action for LGT and a promnesient effect for PGt and LGt.
Vamvakidès
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D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects; D008041:Linoleic Acids / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010169:Palmitic Acids / Q000494:pharmacology*; D010433:Pentylenetetrazole; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013378:Substantia Nigra / Q000187:drug effects
D005971:Glutamates; D008041:Linoleic Acids; D010169:Palmitic Acids; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; C062317:glutamic acid linoleamide; C059900:glutamic acid palmitamide; D010433:Pentylenetetrazole
Effet du palmitamide ou du linoléamide de l'acide glutamique sur les convulsions au pentétrazole.