Clindamycin with primaquine for Pneumocystis carinii pneumonia.
Combined therapy with clindamycin and primaquine was used in twenty-eight episodes of Pneumocystis carinii pneumonia in 25 patients, of whom 17 had been unresponsive or intolerant to conventional treatment and 8 were being treated for the first time. The treatment was effective in all but two episodes, the main adverse reaction being a generalised maculopapular rash.
Toma
E
E
Divisions of Microbiology, Hôtel-Dieu de Montreal, Quebec, Canada.
Fournier
S
S
Poisson
M
M
Morisset
R
R
Phaneuf
D
D
Vega
C
C
D000284:Administration, Oral; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011319:Primaquine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012008:Recurrence
D002981:Clindamycin; D011319:Primaquine