title: Sputum induction for diagnosis of Pneumocystis carinii pneumonia.
abstract: 51 patients infected with the human immunodeficiency virus (HIV) and with suspected Pneumocystis carinii pneumonia underwent sputum induction. Sputum specimens from 18 patients were positive for P carinii and patients were treated appropriately 25 of the 33 patients with negative specimens underwent bronchoscopy and bronchoalveolar lavage within 4 days of sputum induction, only 1 of whom had evidence of Pneumocystis infection. For diagnosis of Pneumocystis carinii pneumonia, sputum induction according to a strict protocol had a sensitivity of 94.7% and a negative predictive value of 96%, compared with bronchoalveolar lavage.
authors.affiliation: Bromptom Hospital, London.
authors.forename: T R
authors.initials: TR
authors.lastname: Leigh
authors.forename: P
authors.initials: P
authors.lastname: Parsons
authors.forename: C
authors.initials: C
authors.lastname: Hume
authors.forename: O A
authors.initials: OA
authors.lastname: Husain
authors.forename: B
authors.initials: B
authors.lastname: Gazzard
authors.forename: J V
authors.initials: JV
authors.lastname: Collins
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D001999:Bronchoscopy; D006801:Humans; D011010:Pneumocystis / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000382:microbiology*; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods; D013183:Sputum / Q000382:microbiology*