Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.
A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinetics of the combined treatment.
Takagi
K
K
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Kuzuya
T
T
Horiuchi
T
T
Nadai
M
M
Apichartpichean
R
R
Ogura
Y
Y
Hasegawa
T
T
D000368:Aged; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D005260:Female; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015363:Quinolones / Q000009:adverse effects / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D006633:Histamine Antagonists; D015363:Quinolones; C048522:repirinast; D013806:Theophylline