title: [Isolation of hemolytic cultures of Bordetella pertussis intended for the production of acellular pertussis preparations and the characterization of their biological properties].
abstract: The heterogeneity of the population of B. pertussis laboratory strains with respect to the capacity of individual clones to lyse erythrocytes has been established. The complete or partial reduction of the antigens under study in nonhemolytic bacteria has been shown. The use of hemolytic cultures for the preparation of acellular pertussis vaccine makes it possible to increase the content of B. pertussis toxin in these vaccines.
authors.forename: L V
authors.initials: LV
authors.lastname: Miriasova
authors.forename: I A
authors.initials: IA
authors.lastname: Vasnak'ian
authors.forename: T V
authors.initials: TV
authors.lastname: Kopaeva
authors.forename: T N
authors.initials: TN
authors.lastname: Remova
authors.forename: E V
authors.initials: EV
authors.lastname: Kozhevnikova
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis; D001886:Bordetella pertussis / Q000254:growth & development / Q000302:isolation & purification*; D006461:Hemolysis; D010567:Pertussis Vaccine / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial; D010567:Pertussis Vaccine
vernacular_title: Vydelenie gemoliticheskikh kul'tur Bordetella pertussis dlia prigotovleniia beskletochnykh kokliushnykh preparatov i kharakteristika ikh biologicheskikh svoĭstv.