Short-contact therapy for psoriasis with 3.9% butantrone (10-butyryl dithranol).
Previous studies have shown that when butantrone and dithranol were used in equimolar gradually increasing concentrations in short-contact therapy for psoriasis the efficacy of butantrone was somewhat lower compared to dithranol. To see whether the efficacy of butantrone in short-contact therapy could be increased by starting with a single high-concentration directly, 20 psoriatic patients were treated with dithranol (0.1,-0.5,-1.0,-2.0%) and butantrone (3.9%) short-contact therapy as a right-left comparison. With these treatment modalities the antipsoriatic effects of dithranol and butantrone were similar. Although the efficacy of 3.9% butantrone was better than the previously used butantrone therapy with gradually increasing doses, there was a parallel increase in side-effects. In general, the side-effects (erythema and staining) remained weaker on the butantrone-treated side than on the dithranol-treated side. No systemic adverse-effects were observed in any of the treated patients.
Remitz
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Department of Dermatology, Helsinki University Central Hospital, Finland.
D000328:Adult; D000368:Aged; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
C038464:butantrone; D000875:Anthralin