[The significance of the kallikrein-kinin system in the pathogenesis of essential hypertension].
The levels of plasma kininase II (ACE), a high molecular weight-kininogen (HMW), alpha 2-mega-globular protein (alpha 2M), prekallikrein (PK), alpha 1-antitrypsin (alpha 1 AT) were determined in essential hypertension and control groups. The results showed that there is significant increase of ACE and PK activity and HMW content in patients with essential hypertension than in control group (P less than 0.001). No changes in alpha 2M and alpha 1AT were found. These results suggest that human plasma kallikrein system was inhibited in patients with essential hypertension.
Jiao
K R
KR
Zhang
S M
SM
Xu
K C
KC
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007610:Kallikreins / Q000097:blood*; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood
D007704:Kininogens; D007705:Kinins; D007703:Peptidyl-Dipeptidase A; D007610:Kallikreins