Parvovirus B19 infection associated with reticulocytopenia and chronic autoimmune hemolytic anemia.
A previously healthy 11-year-old white female presented with a Coomb's positive hemolytic anemia and reticulocytopenia. The patient was treated with prednisone (6.4 mg/kg/day) and had a stable hemoglobin with subsequent recovery of reticulocytes by 7 days. Bone marrow aspiration showed hypercellularity with arrest of red cell maturation. The patient's serum contained specific IgM and IgG antibodies to parvovirus B19. Our report confirms parvovirus B19 as a cause of reticulocytopenia at presentation in autoimmune hemolytic anemia. Immunosuppressive therapy with prednisone did not appear to significantly prolong the course of the B19 infection.
Smith
M A
MA
Department of Pediatric Subspecialities, Geisinger Medical Center, Danville, Pennsylvania.
Shah
N S
NS
Lobel
J S
JS
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000150:complications; D001772:Blood Cell Count; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010322:Parvoviridae Infections / Q000097:blood* / Q000150:complications; D011241:Prednisone / Q000494:pharmacology; D012156:Reticulocytes / Q000187:drug effects
D011241:Prednisone