Gestational changes of GABA levels and GABA binding in the human uterus.
The concentrations of gamma-aminobutyric acid (GABA), the activities of L-glutamate decarboxylase and GABA-transaminase, and the nature of the sodium-independent binding of GABA were examined in uterine tissue pieces obtained surgically from pregnant and non-pregnant women. GABA concentrations were reduced, while the activity of GABA-transaminase and the specific binding of [3H]GABA significantly increased in specimens from pregnant subjects. These findings suggest some gestation-related functional role for the GABA system in the human uterus.
Erdö
S L
SL
Department of Anatomy, Georg-August-University, Göttingen, FRG.
Villányi
P
P
László
A
A
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D001667:Binding, Competitive; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D011247:Pregnancy / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase