[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients.
[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.
Kornhuber
J
J
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Mack-Burkhardt
F
F
Riederer
P
P
Hebenstreit
G F
GF
Reynolds
G P
GP
Andrews
H B
HB
Beckmann
H
H
D000368:Aged; D000927:Anticonvulsants / Q000378:metabolism*; D001923:Brain Chemistry; D003986:Dibenzocycloheptenes / Q000378:metabolism*; D016291:Dizocilpine Maleate; D005260:Female; D006801:Humans; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate