title: Comparative potency of pipecuronium bromide and pancuronium bromide.
abstract: Cumulative dose-response curves were constructed to determine the comparative potency of pipecuronium and pancuronium. From these, the ED50 and ED95 values were calculated. These were 24.96 micrograms kg-1 and 44.96 micrograms kg-1, respectively, for pipecuronium and 30.42 micrograms kg-1 and 61.12 micrograms kg-1, respectively, for pancuronium.
authors.affiliation: Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast.
authors.forename: J C
authors.initials: JC
authors.lastname: Stanley
authors.forename: R K
authors.initials: RK
authors.lastname: Mirakhur
mesh_terms: D000328:Adult; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D000732:Androstanols / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D010197:Pancuronium / Q000493:pharmacokinetics*; D017300:Pipecuronium; D010879:Piperazines / Q000493:pharmacokinetics*; D013810:Therapeutic Equivalency; D013997:Time Factors
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D010197:Pancuronium