Conserved sequences in bacterial and viral sialidases.
The genes of the bacterial sialidases from Clostridium sordellii G12, C. perfringens A99, Salmonella typhimurium LT-2 and Vibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases. Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances between the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9.
Roggentin
P
P
Biochemisches Institut, Christian-Albrechts-Universität, Kiel, W. Germany.
Rothe
B
B
Kaper
J B
JB
Galen
J
J
Lawrisuk
L
L
Vimr
E R
ER
Schauer
R
R
D000595:Amino Acid Sequence; D005075:Biological Evolution; D003013:Clostridium / Q000201:enzymology* / Q000235:genetics; D003016:Clostridium perfringens / Q000201:enzymology* / Q000235:genetics; D005798:Genes, Bacterial; D005814:Genes, Viral; D009980:Influenza A virus / Q000201:enzymology* / Q000235:genetics; D008969:Molecular Sequence Data; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics*
D015678:Viral Structural Proteins