Possible involvement of Epstein-Barr virus (EBV) in polyclonal B-cell activation in Sjögren's syndrome.
The following results suggest that EBV might be involved in the mechanism of polyclonal B-cell activation of Sjögren's syndrome (SS). (1) The levels of serum anti-VCA antibodies of both IgG and IgM class were significantly elevated in SS. (2) Excretion of EBV from the oropharynx was frequently observed in SS. (3) Spontaneously transformed B-cell lines producing a large amount of transforming EBV were established preferentially from SS. (4) An EBV-specific regulatory mechanism was impaired in SS.
Miyasaka
N
N
Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
Yamaoka
K
K
Tateishi
M
M
Nishioka
K
K
Yamamoto
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D036022:Capsid Proteins; D002472:Cell Transformation, Viral; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D009960:Oropharynx / Q000382:microbiology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology / Q000382:microbiology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen