The role of dopaminergic and noradrenergic receptors in human TSH and LH release.
The present study was undertaken to evaluate the relative roles of noradrenergic (NA) and dopaminergic (DA) neurotransmission in the control of thyrotropin (TSH) and luteinizing hormone (LH) release. Oral dextroamphetamine 20 mg caused a rise in the serum levels of TSH and LH in 24 healthy male volunteer subjects. The increase in TSH secretion was augmented by prior treatment with pimozide and reduced by thymoxamine. Conversely the LH response to destroamphetamine was reduced by pimozide and possibly accentuated by thymoxamine. The results confirm an inhibitory role for DA receptors in the control of TSH release and indicate that NA receptors may exert a facilitatory role. The converse would appear to be the case with LH, with DA being facilitatory and NA possibly inhibitory.
Jacobs
D
D
Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK.
Silverstone
T
T
Rees
L
L
D000328:Adult; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003913:Dextroamphetamine; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D010868:Pimozide; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood*
D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D010868:Pimozide; D007986:Luteinizing Hormone; D013972:Thyrotropin; D003913:Dextroamphetamine