title: Proliferative T-cell response to HIV envelope glycoprotein in immunized and infected primates and human beings.
abstract: Human immunodeficiency virus (HIV)-specific helper T-cell response was studied in human subjects and nonhuman primates either infected with HIV or immunized with different HIV protein preparations. A strong group-specific T-cell response involving T-cell proliferation and lymphokine secretion was observed in immunized chimpanzees and rhesus monkeys as well as HIV-infected chimpanzees and gibbons. HIV-infected people demonstrated a low or no HIV-specific T-cell response. In contrast, five of 14 HIV antibody-negative sexual partners of HIV-infected men recognized one or more T-cell epitopes in the envelope glycoprotein of HIV.
authors.affiliation: Institute of Biomedical Sciences, University of Tampere, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Krohn
authors.forename: A
authors.initials: A
authors.lastname: Ranki
authors.forename: P
authors.initials: P
authors.lastname: Lusso
authors.forename: B
authors.initials: B
authors.lastname: Moss
authors.forename: P
authors.initials: P
authors.lastname: Ashorn
authors.forename: L O
authors.initials: LO
authors.lastname: Arthur
authors.forename: S D
authors.initials: SD
authors.lastname: Putney
authors.forename: R C
authors.initials: RC
authors.lastname: Gallo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D015699:HIV Envelope Protein gp120; D015497:HIV-1 / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D006922:Hylobates; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008297:Male; D002679:Pan troglodytes; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D012191:Retroviridae Proteins / Q000276:immunology*; D012747:Sexual Partners; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015699:HIV Envelope Protein gp120; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins