Linkage analysis of the murine mos proto-oncogene on chromosome 4.
A linkage analysis of the murine Mos gene, which codes for the c-mos proto-oncogene, was performed in 88 backcross progeny of an interspecies cross of laboratory mice and Mus spretus. Linkage was tested for four different genes on mouse chromosome 4: Aco-1, Mup-1, b, and Ifb. The gene order (from centromere) with intervening percentage recombination is Mos-15.9 (+/- 3.9)-Aco-1-5.6 (+/- 2.4)-Mup-1-3.4 (+/- 1.9)-b-5.6 (+/- 2.4)-Ifb. These results confirm the previous assignment of Mos to chromosome 4 on the basis of segregation in somatic cell hybrids (D. Swan et al., 1982, J. Virol. 44: 752-754) and show furthermore that Mos and the Ifa/Ifb clusters are not tightly linked as a group of intronless genes, but are separated by a map distance of 30.6 +/- 4.9 recombination units. The linkage data obtained in the present study place Mos in a region compatible with the physical map (D. W. Threadgill and J. E. Womack, 1988, Genomics 3: 82-86).
Dandoy
F
F
CNRS URA 1343, Institut Curie-Biologie, Centre Universitaire, Orsay, France.
De Maeyer-Guignard
J
J
De Maeyer
E
E
D000154:Aconitate Hydratase / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007370:Interferon Type I / Q000235:genetics; D008297:Male; D051379:Mice / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D017231:Proto-Oncogene Proteins c-mos; D011519:Proto-Oncogenes
D007370:Interferon Type I; D011506:Proteins; D011518:Proto-Oncogene Proteins; C035737:major urinary proteins; D017231:Proto-Oncogene Proteins c-mos; D000154:Aconitate Hydratase