title: Spectroscopic analysis of charge transfer complex formation between neuroleptics and iodine.
abstract: Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1:1 stoichiometry and of n-sigma type with these molecules. The values of the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can therefore be expected to interfere with thyroid metabolism.
authors.forename: F
authors.initials: F
authors.lastname: Comby
authors.forename: A C
authors.initials: AC
authors.lastname: Jambut-Absil
authors.forename: J
authors.initials: J
authors.lastname: Buxeraud
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D007455:Iodine / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D014150:Antipsychotic Agents; D007455:Iodine