Further studies on a chemoattractant derived from Aleurites Fordii Hemsl. seed.
1. Activities stimulatory to PMN superoxide generation and chemotactic function were present in two separate gel chromatographic fractions of AFH-S and were designated AFH-S1 (500 kD) and AFH-S2 (38 kD). 2. Characterization studies of these activities revealed physiologic and pharmacologic characteristics dissimilar to those of other previously studied chemoattractants such as bacterial peptide FMLP.
Shichijo
S
S
Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan.
Tsunosue
R
R
Shiraishi
M
M
Iwamoto
M
M
Shibata
H
H
Yokoyama
M M
MM
D002118:Calcium / Q000378:metabolism; D002630:Chemotactic Factors / Q000302:isolation & purification* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte; D006801:Humans; D066298:In Vitro Techniques; D016209:Interleukin-8; D008970:Molecular Weight; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D012639:Seeds / Q000032:analysis; D015398:Signal Transduction; D013481:Superoxides / Q000378:metabolism
D002630:Chemotactic Factors; D016209:Interleukin-8; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002118:Calcium