Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross.
A human Abelson related gene (ABLL) cDNA clone was used to detect restriction fragment length polymorphisms (RFLPs) on mouse Southern blots. Abll was mapped to mouse chromosome 1 by analysis of segregation with other distal chromosome 1 genetic polymorphisms by using a panel of DNAs from [(C3H/HeJ-gld/gld x Mus spretus) F1 x C3H/HeJ-gld/gld] interspecific backcross mice. The data indicate the following gene order: (centromere)-CD45-6.5 cM-Lamb-2-1 cM-Abll-2 cM-At-3. The results extend the analysis of a large conserved linkage group spanning nearly 30 cM on distal mouse chromosome 1 syntenic with human chromosome 1q21-32. Within this linkage group similar relative positions have been characterized in both species for C4BP, REN, CD45, LAMB2, ABLL, AT3, APOA2, and SPTA.
Seldin
M F
MF
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Kruh
G D
GD
D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003433:Crosses, Genetic; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009115:Muridae / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length