[A comparative study of the biological behavior of gastric cancer from the view of the amount of connective tissue in the cancerous tissue--a correlation between the amount of connective tissue and the metastatic pattern].
Differences between advanced gastric cancer of the medullary type (med.: 138 cases) and the scirrhous type (sci: 164 cases) with regard to the amount of connective tissue that was cancerous have been studied clinicopathologically. A correlation was found between med and liver metastasis, and sci and peritoneal dissemination in metastatic types, whereas no correlation was observed in other factors except between med and a localized type, sci and infiltrating type in gross type. The study of tumorigenicity in nude mice showed remarkable difference between med (86.7%) and sci. (0%). These results indicate that there is definite relationship between the amount of connective tissue and the biological behavior of a gastric cancer.
Takakashi
Y
Y
Dept. of Surgery Cancer Research Inst., Kanazawa Univ.
Mai
M
M
Ogino
T
T
Ueda
H
H
Ohi
A
A
Sawaguchi
K
K
Asai
T
T
Ohta
T
T
Suga
T
T
Itoh
T
T
D002293:Adenocarcinoma, Scirrhous / Q000473:pathology / Q000556:secondary; D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000556:secondary; D003238:Connective Tissue / Q000473:pathology*; D006085:Graft Survival; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010534:Peritoneal Neoplasms / Q000556:secondary; D013274:Stomach Neoplasms / Q000473:pathology*