title: Chromosome analysis of in situ breast cancer.
abstract: Eleven ductal carcinoma in situ (DCIS), 5 DCIS with microinvasion and 4 benign lesions have been investigated cytogenetically. Twelve of the 20 breast tumors (60%) had sufficient mitotic activity for chromosome analysis. All ductal carcinoma in situ had abnormal karyotypes, and clonal marker chromosomes could be identified in all tumors analyzed. None were cytogenetically normal. All but one of the 12 DCIS showed genetic heterogeneity. Tumor progression seems to be associated with loss of chromosomes.
authors.affiliation: Department of Pathology, Odense University Hospital, Denmark.
authors.forename: K V
authors.initials: KV
authors.lastname: Nielsen
authors.forename: M
authors.initials: M
authors.lastname: Blichert-Toft
authors.forename: J
authors.initials: J
authors.lastname: Andersen
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002278:Carcinoma in Situ / Q000235:genetics*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics*; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D011003:Ploidies
chemical_list: D005819:Genetic Markers