title: Analysis of lymphoepithelioma and lymphoepithelioma-like carcinomas for Epstein-Barr viral genomes by in situ hybridization.
abstract: Lymphoepithelioma of the nasopharynx has a strong association with Epstein-Barr virus (EBV). To test the hypothesis that lymphoepithelioma-like carcinomas occurring at other sites are also associated with EBV virus, we used in situ hybridization to analyze 20 cases of lymphoepithelioma and histologically similar lesions and five basaloid squamous cell carcinomas for evidence of EBV genomes. EBV genomes were demonstrated in six of six lymphoepitheliomas of the nasopharynx but in none of five basaloid squamous cell carcinoma. Only one of 14 lymphoepithelioma-like carcinomas was found to contain EBV genomes. The single positive lymphoepithelioma-like carcinoma occurred in the lung of an Asian patient, suggesting that ethnic or geographic influences may be important in determining whether EBV is associated with these nonnasopharyngeal neoplasms. Despite their histologic similarity, most lymphoepithelioma-like carcinomas probably have a different pathogenesis from nasopharyngeal lymphoepithelioma.
authors.affiliation: Department of Pathology, Stanford University, California 94305.
authors.forename: L M
authors.initials: LM
authors.lastname: Weiss
authors.forename: L A
authors.initials: LA
authors.lastname: Movahed
authors.forename: A E
authors.initials: AE
authors.lastname: Butler
authors.forename: S A
authors.initials: SA
authors.lastname: Swanson
authors.forename: H F
authors.initials: HF
authors.lastname: Frierson
authors.forename: P H
authors.initials: PH
authors.lastname: Cooper
authors.forename: T V
authors.initials: TV
authors.lastname: Colby
authors.forename: S E
authors.initials: SE
authors.lastname: Mills
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010039:Otorhinolaryngologic Neoplasms / Q000382:microbiology; D012878:Skin Neoplasms / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000382:microbiology
chemical_list: D004279:DNA, Viral