Immunocytochemical localization of the GABAA/benzodiazepine receptor in the guinea pig cochlear nucleus: evidence for receptor localization heterogeneity.
Immunocytochemistry with a monoclonal antibody against the GABAA/benzodiazepine receptor showed labeled axo-dendritic synapses in the anteroventral cochlear nucleus. In the dorsal cochlear nucleus, label was seen apposing both axo-somatic and axo-dendritic terminals. The results suggest a heterogeneous distribution of GABA receptors, together with a possible segregation of receptor subtypes between somata and dendrites in certain neurons. The presence of cytoplasmic labeling in some neurons might reflect a higher receptor turnover rate in these neurons.
Juiz
J M
JM
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109.
Helfert
R H
RH
Wenthold
R J
RJ
De Blas
A L
AL
Altschuler
R A
RA
D000818:Animals; D003056:Cochlear Nerve / Q000166:cytology / Q000378:metabolism*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D011963:Receptors, GABA-A / Q000378:metabolism*; D012249:Rhombencephalon / Q000166:cytology / Q000378:metabolism*
D011963:Receptors, GABA-A