[Reverse phase high performance liquid chromatography in the synthesis of leukotrienes A4 and C4].
The chromatographic (RP HPLC) behaviour of leukotriene C4, its methyl ester, leukotriene A4 methyl ester and some chemicals involved in their synthesis have been investigated. Optimal conditions of separation were determined for the gradient and isocratic HPLC. Parameters of the interaction of the substances with hydrophobic surface are discussed in terms of solvophobic theory.
Galushko
S V
SV
Belik
M Iu
MIu
Sorochinskiĭ
A E
AE
Kornilov
A M
AM
Kukhar'
V P
VP
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D005978:Glutathione / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D017572:Leukotriene A4; D015289:Leukotrienes / Q000138:chemical synthesis* / Q000302:isolation & purification; D013189:SRS-A / Q000138:chemical synthesis* / Q000302:isolation & purification
D017572:Leukotriene A4; D015289:Leukotrienes; D013189:SRS-A; D005978:Glutathione
Obrashchenno-fazovaia vysokoéffektivnaia zhidkostnaia khromatografiia v sinteze leĭkotrienov A4 i C4.