[Anti-cytoplasmic antibodies of neutrophil granulocytes in systemic vasculitis].
Autoantibodies to the cytoplasmic components of neutrophil polymorphonuclear granulocytes (ACPA) were searched for by indirect immunofluorescence on ethanol-fixed smears from normal white blood cells in 248 sera from patients with Wegener's granulomatosis, Kawasaki disease and various other vasculitides, connective tissue diseases, nephropathies and infiltrative pulmonary diseases. Apart from a weak positivity in a few Kawasaki disease sera, ACPA were found in Wegener's granulomatosis (and micropolyarteritis) only, with a correlation between ACPA titers and disease activity. These results confirm the value of ACPA in the diagnosis and evaluation of activity of Wegener's granulomatosis.
Brugier
J C
JC
CNRS UA 1172, CHUR La Milétrie, Poitiers.
Touchard
G
G
Lê Thi Huong
D u
Du
Lebranchu
Y
Y
Preud'homme
J L
JL
D000906:Antibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D003593:Cytoplasm / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D010488:Polyarteritis Nodosa / Q000276:immunology
D000906:Antibodies; D015415:Biomarkers
Anticorps anti-cytoplasme des polynucléaires neutrophiles dans les vascularites systémiques.