title: Studies of the effect of recombinant human-alpha 1 interferon on experimental parainfluenza type 3 virus infections of the respiratory tract of calves.
abstract: The effect of the administration of recombinant human interferon on the severity of clinical disease and the extent of pneumonic lesions in calves infected experimentally with bovine parainfluenza 3 (PI3) virus was studied in two experiments. In the first, three pairs of calves aged seven to 10 days were used; one of each pair was injected intramuscularly with 10(6) units of interferon/kg bodyweight for three consecutive days, and the other was left untreated. On the day after the first injection of interferon all the calves were challenged with PI3 virus, a different dose being administered to each pair. There was no evidence of any protective effect from the treatment with interferon. The second experiment used eight, six-week-old calves; four were inoculated in the same way with interferon and all the calves were challenged with the same dose of PI3. Again, there was no evidence of a reduction either in the severity of clinical disease or in the extent of lung consolidation in the calves treated with interferon.
authors.affiliation: Department of Agriculture, Veterinary Research Laboratories, Stormont, Belfast.
authors.forename: D G
authors.initials: DG
authors.lastname: Bryson
authors.forename: M S
authors.initials: MS
authors.lastname: McNulty
authors.forename: R T
authors.initials: RT
authors.lastname: Evans
authors.forename: G
authors.initials: G
authors.lastname: Allan
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology / Q000628:therapy*; D007273:Injections, Intramuscular; D007370:Interferon Type I / Q000627:therapeutic use*; D008171:Lung Diseases / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D018184:Paramyxoviridae Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins