Turcot's syndrome: a diagnostic consideration in a child with primary adenocarcinoma of the colon.
We report the diagnosis of an adenocarcinoma of the colon in a 12-year-old girl in association with the presence of a small number of adenomatous polyps and a positive family history of a sibling with a central nervous system glioma. These findings implicate Turcot's syndrome as the cause for the development of intestinal and intracranial neoplasms in the two siblings. Since primary adenocarcinoma of the bowel is unusual in children, an underlying predisposing condition should be sought in affected cases.
Tithecott
G A
GA
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Filler
R
R
Sherman
P M
PM
D000230:Adenocarcinoma; D011125:Adenomatous Polyposis Coli; D002493:Central Nervous System Diseases; D002648:Child; D003110:Colonic Neoplasms; D003111:Colonic Polyps; D003113:Colonoscopy; D005260:Female; D005910:Glioma; D006801:Humans