Marked locomotor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine.
The present study demonstrates that the muscarinic antagonist atropine and the alpha-adrenergic agonist clonidine, though ineffective when administered separately, produced a pronounced locomotor stimulation in monoamine-depleted mice when combined. The atropine + clonidine-induced locomotor stimulation was counteracted by both the alpha 2-adrenoceptor antagonist idazoxan and the acetylcholinesterase inhibitor physostigmine. Thus, it is clear that simultaneous manipulations with cholinergic and adrenergic systems are as effective in restoring locomotion in monoamine-depleted mice as increasing central dopaminergic tone. This finding may have implications for the treatment of a movement disorder like Parkinson's disease.
Carlsson
M
M
Department of Pharmacology, University of Göteborg, Sweden.
Carlsson
A
A
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D012110:Reserpine / Q000494:pharmacology
D015306:Biogenic Monoamines; D011942:Receptors, Adrenergic, alpha; D011976:Receptors, Muscarinic; D001285:Atropine; D012110:Reserpine; D003000:Clonidine