title: [The role of guanidine groups of arginine residues of Na, K-ATPase and glutamate dehydrogenase in an interaction with cholesterol].
abstract: Cholesterol was studied in experiments in vitro for its effect on the activity of Na, K-ATPase of the synaptic brain membranes of rats and a crystalline preparation of glutamate dehydrogenase from the liver mitochondria of a bull. Cholesterol decreased the activity of the above enzymes. When blocking guanidine groups of arginine residues of Na, K-ATPase and glutamate dehydrogenase the inhibiting action of cholesterol was absent. The obtained data evidence for the possibility of a direct interaction of cholesterol with membrane enzymes as well as for the important significance of guanidine groups of arginine residues of proteins in the process.
authors.forename: N N
authors.initials: NN
authors.lastname: Kliueva
authors.forename: I M
authors.initials: IM
authors.lastname: Matveeva
authors.forename: K A
authors.initials: KA
authors.lastname: Kozhevnikova
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D002417:Cattle; D002784:Cholesterol / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D019791:Guanidine; D006146:Guanidines / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013570:Synaptic Membranes / Q000201:enzymology
chemical_list: D006146:Guanidines; D001120:Arginine; D002784:Cholesterol; D005969:Glutamate Dehydrogenase; D000254:Sodium-Potassium-Exchanging ATPase; D019791:Guanidine
vernacular_title: Rol' guanidinovykh grupp argininovykh ostatkov Na, K-ATPazy i glutamatdegidrogenazy vo vzaimodeĭstvii s kholesterinom.