Use of auditory evoked responses as a measure of recovery from benzodiazepine sedation.
The amplitude of the P300 component of auditory evoked responses was found to be depressed by benzodiazepine sedation and was subsequently used to monitor the recovery of volunteers sedated with midazolam. The amplitude of the evoked responses was found to be highly correlated with blood midazolam levels but to be no more sensitive than standard psychomotor testing in assessing recovery from sedation.
Milligan
K R
KR
Department of Anaesthetics, Queen's University, Belfast.
Lumsden
J
J
Howard
R C
RC
Howe
J P
JP
Dundee
J W
JW
D000328:Adult; D000762:Anesthesia Recovery Period; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D008874:Midazolam / Q000097:blood / Q000494:pharmacology; D008954:Models, Biological; D011184:Postoperative Period; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects
D014151:Anti-Anxiety Agents; D008874:Midazolam