title: [Comparative sensitivity of the sympathetic and parasympathetic ganglia to ganglionic blockaders].
abstract: Pharmacological tests in vitro on the cat isolated superior cervical and ciliary ganglia identified the IEM-1194 as a selective parasympathetic ganglion-blocking agent. The ganglion-blocking activity of this drug was three times as high in parasympathetic ganglion (EC50 = 1.15 +/- 0.34 M/1 x 10(-5)) as in sympathetic one (EC50 = 3.2 +/- 0.2 M/1 x 10(-5)). I. v. administration of the IEM-1194 in a dose effectively (50%) blocking responses of the heart (bradycardia) and duodenum (peristaltics) to vagal stimulation, did not lower arterial blood pressure.
authors.forename: L V
authors.initials: LV
authors.lastname: Me'lnichenko
authors.forename: V V
authors.initials: VV
authors.lastname: Gerzanich
authors.forename: V E
authors.initials: VE
authors.lastname: Gmiro
authors.forename: V I
authors.initials: VI
authors.lastname: Skok
mesh_terms: D000818:Animals; D002415:Cats; D003470:Culture Media; D005726:Ganglia, Parasympathetic / Q000187:drug effects*; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D005730:Ganglionic Blockers / Q000494:pharmacology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D009433:Neural Inhibition / Q000187:drug effects; D011437:Propylamines / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D011437:Propylamines; C060661:N-decyl-N,N-diisopropylamine
vernacular_title: Sravnenie chuvstvite'lnosti simpaticheskogo i parasimpaticheskogo gangliev k deĭstviiu ganglioblokatorov.