Latent iron deficiency alters gamma-aminobutyric acid and glutamate metabolism in rat brain.
A diet containing 18-20 mg iron/kg to young weaned rats for 8 weeks altered the metabolism of gamma-aminobutyric acid and glutamate in the central nervous system without affecting blood hemoglobin. Subsequent rehabilitation with 390 mg iron/kg diet for 2 weeks normalized these changes.
Shukla
A
A
Department of Pediatrics, Banaras Hindu University, Varanasi, India.
Agarwal
K N
KN
Shukla
G S
GS
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004032:Diet; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007501:Iron / Q000008:administration & dosage; D000090463:Iron Deficiencies; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D007501:Iron; D005969:Glutamate Dehydrogenase; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase