Synthesis and biological activity of dansyl thymidines.
The synthesis of thymidines selectively dansylated in the 3'- and 5'-positions is reported. The biological investigation showed that these fluorescent nucleosides behave as competitive inhibitors of thymidine kinase (TK) from herpes simplex virus (HSV) and are endowed with a certain degree of antiviral activity against HSV-2 and HSV-1.
Bonora
G M
GM
Centro di Studi Sui Biopolimeri, C.N.R., Dipartimento di Chimica Organica, Università di Padova.
Palù
G
G
Dos Santos
C
C
Biasolo
M A
MA
Meloni
G A
GA
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D003619:Dansyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors; D014616:Vaccinia virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D003619:Dansyl Compounds; D013937:Thymidine Kinase; D013936:Thymidine