title: Spontaneous immune complex orchitis in brown Norway rats.
abstract: Immune complexes occur spontaneously in the testis of Brown-Norway (BN) inbred rats between the basal lamina of the seminiferous tubules and the outer lamina of the myoid testicular cells. The deposits can be detected immunohistologically (IgG; C3) and by electron microscopy. The immune complexes appear between the 8th and 12th weeks of life, increase in amount up to the 30th week and decrease thereafter. After about the 20th week, of life, 15% of the animals show destruction of the germinal epithelium accompanied by an infiltration of lymphocytes and plasma cells. The final stage of this disease, which initially shows no signs of inflammation, is characterized by diffuse tubular atrophy. However, up to the 70th week of life, 85% of the animals with immune complexes show no pathological alterations. Antibodies eluated from the testes react with spermatocytes I and structures close to the lumen of the seminiferous tubules, but not with mature sperms. Serum antibodies to sperms occur in about 25% of the BN rats, but the presence of these antibodies shows no correlation with the immunohistological findings. This newly described spontaneous immune complex orchitis is regarded as a further example of an in-situ-induced immune complex disease. The observations made here can be compared with those in (peri-) membraneous glomerulonephritis, another example of a disorder resulting from in-situ-formation of immune deposits.
authors.affiliation: Medizinische Klinik Innenstadt, Ludwig-Maximilians-Universität München, Federal Republic of Germany.
authors.forename: C
authors.initials: C
authors.lastname: Fürbeth
authors.forename: G
authors.initials: G
authors.lastname: Hübner
authors.forename: G H
authors.initials: GH
authors.lastname: Thoenes
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D007105:Immune Complex Diseases / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009920:Orchitis / Q000276:immunology / Q000473:pathology*; D051381:Rats