Influence of trichloroethylene treatment on phosphoinositides in rat brain.
The effect of oral administration of trichloroethylene, a neurotoxic solvent, on the levels of phosphoinositides in rat brain was studied. Two hours after administration of a single dose of trichloroethylene (1000 mg/kg body wt.), the levels of phosphatidylinositol (PI) and phosphatidylinositol 4,5-biphosphate (PIP2) were reduced by 24 and 17%, respectively, without any significant change in that of phosphatidylinositol-4-phosphate (PIP). Twenty hours after treatment, the levels of PI and PIP2 were increased by 22 and 38%, respectively. Repeated administration of the same dose of trichloroethylene for 1 year markedly reduced the levels of PI (52%), PIP (23%) and PIP2 (45%). These results for the first time suggest the involvement of a phosphoinositide messenger system in trichloroethylene neurotoxicity.
Subramoniam
A
A
Industrial Toxicology Research Centre, Lucknow, India.
Goel
S K
SK
Pandya
K P
KP
Seth
P K
PK
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D009498:Neurotoxins / Q000633:toxicity*; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014241:Trichloroethylene / Q000633:toxicity*
D009498:Neurotoxins; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C037178:phosphatidylinositol 4-phosphate; D014241:Trichloroethylene