Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.
Spyratos
F
F
Centre René Huguenin, Saint-Cloud, France.
Maudelonde
T
T
Brouillet
J P
JP
Brunet
M
M
Defrenne
A
A
Andrieu
C
C
Hacene
K
K
Desplaces
A
A
Rouëssé
J
J
Rochefort
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000601:surgery; D002402:Cathepsin D / Q000032:analysis*; D004792:Enzyme Precursors / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011863:Radioimmunoassay
D014408:Biomarkers, Tumor; D004792:Enzyme Precursors; C058345:procathepsin D; D002402:Cathepsin D