[Influence of chronically-administered enalapril on isotonic and isometric exercise in patients with moderate grade hypertension].
We studied 11 patients affected by mild essential hypertension during chronic therapy with enalapril (E). After a pharmacological wash-out the patients were treated with E once a day (10-20 mg) for 4 weeks. Before and after the treatment period the patients were studied by means of the isotonic exercise stress test on the cycloergometer with increments of 25 W every 2 min and by means of the Sustained Handgrip test (SHG) at 70% of maximal capacity for 1 min. During the study period E reduced the blood pressure at rest in all patients without untoward effects. During the isotonic test and particularly during SHG, E reduced systolic and diastolic blood pressure (BP) and the product systolic BP x heart rate. The treatment did not influence the time length of the isotonic exercise stress test. Our results suggest that E does not increase the MVO2 at rest and during different types of exercise: this can be very important because many patients affected by hypertension suffer from ischemic heart disease. E is utilized also in patients with heart failure, some of whom have an hypertensive or ischemic cardiomyopathy.
De Biase
L
L
Sulpizii
L
L
Levantesi
G
G
Amorosi
C
C
De Felice
M
M
Gallo
P
P
Campa
P P
PP
D000328:Adult; D000368:Aged; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D004656:Enalapril
Influenza dell'enalapril in somministrazione cronica sul lavoro isotonico ed isometrico in pazienti ipertesi di grado lieve-moderato.