[Effect of drugs possessing antialcoholic activity on ethanol pharmacokinetics].
Furazolidone, lithium carbonate, chlorprotixen and pyrroxan exert different effects on ethanol pharmacokinetics. Furazolidone decreases clearance of ethanol, increases its half-life with a simultaneous reduction of blood acetaldehyde concentration. Pyrroxan increases clearance and maximal concentration of ethanol. Chloprotixen effect is characterized by a concurrent increase of ethanol and acetaldehyde concentrations in the first hours after ethanol administration. Lithium carbonate produces no significant changes in ethanol pharmacokinetic parameters.
Lelevich
V V
VV
Pron'ko
P S
PS
Liopo
A V
AV
Deniskovets
A A
AA
D000079:Acetaldehyde / Q000097:blood; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000427:Alcohol Deterrents / Q000494:pharmacology*; D000818:Animals; D002749:Chlorprothixene / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D000431:Ethanol / Q000493:pharmacokinetics*; D005664:Furazolidone / Q000494:pharmacology*; D006207:Half-Life; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000427:Alcohol Deterrents; D004146:Dioxanes; D004147:Dioxins; D016651:Lithium Carbonate; D000431:Ethanol; D005664:Furazolidone; D008094:Lithium; D002749:Chlorprothixene; D000079:Acetaldehyde; C009143:proroxan
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