title: [Intermediator relation of the CNS and the improvement in the agents for therapy of drug poisoning].
abstract: Intoxication induced by any "synaptic" poison is followed by the involvement in the pathological process of not only the mediator "target-system" but also other closely interrelated neurotransmitter systems of the brain. The functional condition of every of the systems may be of certain importance for the development of evident manifestations of intoxications. The study of the laws of the interactions of neurotransmitter systems in the central nervous system and their responses to intoxications may become the basis for the search of new effective drugs enhancing efficacy of classical antidotes of synaptic poisons.
authors.forename: S A
authors.initials: SA
authors.lastname: Kutsenko
authors.forename: N V
authors.initials: NV
authors.lastname: Savateev
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006651:Histocytochemistry; D018377:Neurotransmitter Agents / Q000502:physiology*; D011041:Poisoning / Q000188:drug therapy* / Q000503:physiopathology; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D000931:Antidotes; D018377:Neurotransmitter Agents
vernacular_title: Izuchenie mezhmediatornykh vzaimootnosheniĭ v TsNS i sovershenstvovanie sredstv terapii intoksikatsiĭ lekartsvennymi preparatami.