Role of Salmonella enteritidis lipopolysaccharide on anti-HSV activity of macrophages from different anatomical sites.
It is generally agreed that endotoxins from Gram-negative bacteria play a modulatory role on several macrophage functions. The intrinsic activity versus herpes simplex virus type 1 and type 2 of Kupffer cells, peritoneal and alveolar macrophages, harvested from normal and tumour-bearing rats, was evaluated. Moreover, the effects of different intravenous treatments with S. enteritidis endotoxin were investigated. The antiviral activity of peritoneal, alveolar macrophages and Kupffer cells from tumour-bearing rats is definitely impaired but it appears to be positively modulated by in-vivo administration of S. enteritidis lipopolysaccharide (LPS).
Arena
A
A
Institute of Medical Microbiology, University of Messina, Italy.
Merendino
R A
RA
Mastroeni
P
P
Mancuso
G
G
Costa
G B
GB
Bonina
L
L
D000818:Animals; D005260:Female; D007728:Kupffer Cells / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology; D009928:Organ Specificity; D010529:Peritoneal Cavity / Q000166:cytology; D011650:Pulmonary Alveoli / Q000166:cytology; D051381:Rats; D012477:Salmonella enteritidis; D018139:Simplexvirus / Q000276:immunology*
D008070:Lipopolysaccharides; C036757:lipopolysaccharide B