Superoxide anion in polymorphonuclear leukocytes of hairless rats suffering from magnesium-deficiency dermatitis.
Clinical and histological studies were made on magnesium-deficiency dermatitis produced on a new strain of hairless rats. Superoxide anion generation in polymorphonuclear leukocytes (PMNs) and the inhibitory effect of some antioxidants and anti-inflammatory agents against the elicited dermatitis were also examined. From the detection of increased superoxide production and effective actions of inhibitors including superoxide dismutase, cepharanthine, 4-4'-diamono-diphenylsulphone and 5,4,11,14-eicosatetraynoic acid (ETYA), it is indicated that superoxide anion or related activated oxygen may be responsible for magnesium-deficiency dermatitis as an inflammatory mediator and that the dermatitis may be related to lipoxygenase metabolites derived from arachidonic acid.
Hanada
K
K
Hashimoto
I
I
D000818:Animals; D003872:Dermatitis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008275:Magnesium Deficiency / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism*; D051381:Rats; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides