Experimental investigation of a new iodinated lipid emulsion for computed tomography of the liver.
Iodinated lipid emulsions are highly efficient macrophage imaging agents. Nevertheless, none of them has been accepted for clinical use because of adverse reactions. We have tested a new iodinated lipid emulsion, Intraiodol. The size and surface properties of the particles of this emulsion are similar to those of Intralipid which in turn closely resemble the naturally occurring chylomicrons. Using computed tomography (CT) of the rabbit liver as well as vital microscopy and electron microscopy of the rat liver we found that Intraiodol has low efficiency as a liver-specific contrast medium because its particles are predominantly taken up by the hepatocytes and to a less extent by the Kupffer cells, as is Intralipid. The low efficiency of Intraiodol could be fully compensated by an increase in dosage without any significant effect on sinusoidal blood flow. This in turn suggests that the likelihood of release of toxic mediators (and thereby related adverse reactions from activated macrophages) is reduced. We believe that this new way of delivering iodinated lipid particles to the liver represents an important advance in the search for a non-toxic lipid emulsion for CT of the liver.
Ivancev
K
K
Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Lunderquist
A
A
McCuskey
R
R
McCuskey
P
P
Wretlind
A
A
D000818:Animals; D003287:Contrast Media / Q000633:toxicity; D004655:Emulsions; D004998:Ethiodized Oil / Q000633:toxicity; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology* / Q000633:toxicity; D005990:Glycerol; D007459:Iodized Oil / Q000494:pharmacology* / Q000633:toxicity; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000648:ultrastructure; D008833:Microcirculation / Q000187:drug effects; D010316:Particle Size; D010588:Phagosomes / Q000187:drug effects; D010743:Phospholipids; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; C039040:ethiodized oil emulsion 13; C061080:ethiodized oil, glycerol, phospholipid emulsion; C011604:AG 60.99; D007459:Iodized Oil; D004998:Ethiodized Oil; D005990:Glycerol