The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239.
Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3.6 for alpha particles at low doses.
Bilbao
A
A
Departamento de Biologíe Celular e Histología, Facultad de Medicina, Universidad deĺ País Vasco, Leioa, Vizcaya, Spain.
Prosser
J S
JS
Edwards
A A
AA
Moody
J C
JC
Lloyd
D C
DC
D000512:Alpha Particles; D002869:Chromosome Aberrations / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D011005:Plutonium
D011005:Plutonium