Protection of murine foot tissue and transplantable tumor against Photofrin-II-mediated photodynamic sensitization with WR-2721.
Four thiol-containing compounds, WR-2721, WR-149024, WR-168643 and WR-361, were compared as photoprotectors of murine feet. The protector doses were the maximal tolerated intraperitoneal doses, administered 24 h after injection of Photofrin II and 15 min before illumination with 630-nm laser light. While all four compounds were effective, only WR-2721 demonstrated a statistically significant attenuation of phototoxicity. WR-2721 was found to protect SMT-F tumors in the same mouse strain, using tumor growth delay and short-term control as endpoints. A comparison of the dose modification factors for foot and tumor responses indicated no therapeutic advantage in using WR-2721 during photodynamic treatment of these two tissues.
Bellnier
D A
DA
Oncologic Foundation of Buffalo, NY 14203.
Dougherty
T J
TJ
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D017323:Dihematoporphyrin Ether; D004353:Drug Evaluation, Preclinical; D005260:Female; D005528:Foot; D006415:Hematoporphyrins / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D010778:Photochemotherapy; D011837:Radiation-Protective Agents / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
D006415:Hematoporphyrins; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D017323:Dihematoporphyrin Ether; D004999:Amifostine