Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction.
The effect of low-dose (2 Gy) radiation on ethylnitrosourea (ENU)-induced neoplasms was studied in Sprague-Dawley and Holtzman strains of rats. With a 60 mg/kg dose of ENU administered on day 1 in Sprague-Dawley rats, 18.4% of the neoplasms induced were found in the kidney. When the same dose of ENU was given on day 10, the incidence of kidney tumors fell to 2.8%. Prior (2 Gy) radiation on day 9 enhanced kidney tumor induction to 16.1%, a trend also observed in the case of ENU-induced neural tumors. In Holtzman rats, 40 mg/kg ENU induced more kidney tumors (12.5%) when given on day 4 than on day 0, and prior irradiation enhanced the ENU-induced kidney tumors even though the interval between irradiation and carcinogen administration was fairly long--4 days.
Hasgekar
N N
NN
Cell and Developmental Pathology Division, Cancer Research Institute, Parel, Bombay, India.
Pendse
A M
AM
Lalitha
V S
VS
D000818:Animals; D003037:Cobalt Radioisotopes; D004195:Disease Models, Animal; D005038:Ethylnitrosourea / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000139:chemically induced*; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014916:Whole-Body Irradiation; D009396:Wilms Tumor / Q000139:chemically induced*
D003037:Cobalt Radioisotopes; D005038:Ethylnitrosourea