Persistent hypotensive effect of L-dopa given early during development to rats with inherited stress-induced arterial hypertension.
A long-lasting decrease of the basal and stress-induced arterial blood pressure was obtained in rats with inherited emotional stress-induced arterial hypertension by means of injections of the dopamine precursor L-DOPA during early development (21-25 days after birth). The restoring effect of L-DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline and, presumably, with increase of tyrosine hydroxylase activity in the cortex and hindbrain.
Naumenko
E V
EV
Institute of Cytology and Genetics, Siberian Department of the Academy of Sciences of the U.S.S.R., Novosibirsk.
Maslova
L N
LN
Gordienko
N I
NI
Amstyslavski
S Y
SY
Dygalo
N N
NN
Markel
A L
AL
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism* / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000150:complications* / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine