Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system.
We compared adrenocorticotropin-releasing activities of several interleukins in a homologous or heterologous in vivo system. Intravenous injection of rat interleukin-1 alpha significantly increased plasma adrenocorticotropin in conscious, freely-moving rats 30 min after the injection, and the effect was 10 times greater than that of human interleukin-1 alpha. Rat interleukin-2 affected plasma adrenocorticotropin in a much slower manner and increased its levels significantly 120 min after the injection. Human interleukin-2 had no effect on plasma adrenocorticotropin. Thus, species difference in the experimental system should be considered to assess the physiological significance of cytokines in the neuroendocrine system.
Naito
Y
Y
Department of Anesthesia, Kyoto University Faculty of Medicine, Japan.
Fukata
J
J
Tominaga
T
T
Masui
Y
Y
Hirai
Y
Y
Murakami
N
N
Tamai
S
S
Mori
K
K
Imura
H
H
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D013329:Structure-Activity Relationship
D007375:Interleukin-1; D007376:Interleukin-2; D011994:Recombinant Proteins; D000324:Adrenocorticotropic Hormone