The effect of propranolol on cAMP concentration in the rat preoptic region during the wake-sleep cycle.
In control conditions preoptic cAMP concentration during wakefulness was significantly higher than during synchronized sleep. No differences in nucleotide concentration were observed in the cerebral cortex. Propranolol decreases brain cAMP concentration. This change was associated with the suppression of the difference observed between wakefulness and synchronized sleep in the preoptic region.
Perez
E
E
Zamboni
G
G
Amici
R
R
Fadiga
L
L
Calasso
M
M
Parmeggiani
P L
PL
D000204:Activity Cycles / Q000187:drug effects*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism*; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D011433:Propranolol; D000242:Cyclic AMP