Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32.
Through the use of a cDNA probe, the human erbB-2 gene was localized by in situ hybridization of normal human chromosomes at 17q11-q21. In situ hybridization of chromosomes derived from fibroblasts carrying a constitutional 15;17t(q22.3;q11.21) translocation showed that the erbB-2 gene was relocated on the rearranged chromosome 15. These results as well as grain localization on prophase chromosomes locate the erbB-2 gene at 17q12-q21.32. This localization may facilitate the search for human malignancies with chromosome changes involving the erbB-2 gene.
Popescu
N C
NC
Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20892.
King
C R
CR
Kraus
M H
MH
D001483:Base Sequence; D002460:Cell Line; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17 / Q000648:ultrastructure*; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D014178:Translocation, Genetic
D015342:DNA Probes; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases