title: Developmental changes of calpain and calpastatin in rabbit brain.
abstract: A major part of the Ca-activated proteolytic activity in the soluble fraction from rabbit brain could be due to the activity of the neutral thiol-proteases calpain I and II. The activity of calpains exceeded that of the endogenous inhibitor, calpastatin, at all developmental stages studied. The level of calpains increased rapidly from the prenatal stage to reach a peak 10-20 days postnatally. From this period the level of calpains decreased slowly to reach the adult levels. The level of calpastatin increased steadily from the prenatal stage to old age.
authors.affiliation: Institute of Neurobiology, University of Göteborg, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Blomgren
authors.forename: J O
authors.initials: JO
authors.lastname: Karlsson
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D002135:Calcium-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D002154:Calpain / Q000378:metabolism* / Q000502:physiology; D005314:Embryonic and Fetal Development; D011817:Rabbits
chemical_list: D002135:Calcium-Binding Proteins; C033668:calpastatin; D002154:Calpain