Role of neurotransmitters in fenitrothion-induced aggressive behaviour in normal and lesioned rats.
Normal and brain-lesioned (amygdala, septal and nigral regions) rats exposed to fenitrothion (10 mg/kg) for 15 subsequent days showed elevated foot-shock fighting behaviour (septal and nigral lesioned rats). Treated animals failed to perform the rotorod test and showed decreased locomotor activity followed by convulsions. The brain-lesioned rats treated with 10 mg/kg fenitrothion showed a marked decrease in the level of norepinephrine (NE) and serotonin (5-HT).
Anand
M
M
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Gulati
A
A
Gopal
K
K
Gupta
G S
GS
Chandra
S V
SV
D000374:Aggression / Q000187:drug effects*; D000679:Amygdala / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D005260:Female; D005278:Fenitrothion / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D012688:Septum Pellucidum / Q000502:physiology; D013378:Substantia Nigra / Q000502:physiology
D018377:Neurotransmitter Agents; D005278:Fenitrothion