[Myeloperoxidase deficiency of the peripheral blood neutrophils and the incidence of infectious complications in patients with acute myeloblastic leukemia].
The myeloperoxidase activity of polymorphonuclear peripheral blood neutrophils was studied in 60 patients with acute myeloblastic leucosis. It was established that patients with low peroxidase activity, frequency of infectious complications was 3.7 times higher than in patients with normal peroxidase activity. Hence, reduced myeloperoxidase activity of polymorphonuclear neutrophils in acute myeloblastic leucosis causes a decrease of the bactericidal activity of the cells.
Tishchenko
L M
LM
Guseva
S A
SA
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis* / Q000276:immunology; D001770:Blood Bactericidal Activity; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D009195:Peroxidase / Q000097:blood / Q000172:deficiency*
D009195:Peroxidase
Defitsit mieloperoksidazy neĭtrofilov perifericheskoĭ krovi i chastota infektsionnykh oslozhneniĭ u bol'nykh ostrym mieloblastnym leĭkozom.