title: Hyperoxia decreases lung size of amphibian tadpoles without changing GSH-peroxidases or tissue peroxidation.
abstract: 1. During the development of D. pictus larvae (Amphibia) in normoxia, selenium (Se) GSH-Px increased whereas non-Se GSH-Px did not change. 2. Acclimation to 60 or 100% O2 did not change Se GSH-Px or non-Se GSH-Px. 3. Hyperoxia did not change tissue peroxidation (TBA-RS) confirming the good capacity of D. pictus tadpoles for O2-adaptation. 4. Since hyperoxic induction of catalase (CAT) has been previously described in D. pictus tadpoles, it is concluded that CAT is more important than both GSH-Px for the establishment of O2-adaptation. 5. Increases of Se GSH-Px, SOD and CAT, are probably important for adaptation to the change from aquatic to aerial environment during metamorphosis in normoxia. 6. Chronic exposure to 100% O2 enormously reduced the lung size of D. pictus larvae.
authors.affiliation: Department of Animal Biology-II (Animal Physiology), Faculty of Biology, Complutense University, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Barja de Quiroga
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Torres
authors.forename: P
authors.initials: P
authors.lastname: Gil
mesh_terms: D000222:Adaptation, Physiological; D000663:Amphibians / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007814:Larva / Q000033:anatomy & histology / Q000378:metabolism; D015227:Lipid Peroxidation; D008168:Lung / Q000033:anatomy & histology* / Q000187:drug effects; D008675:Metamorphosis, Biological; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D010100:Oxygen