title: Wilms tumour in a patient with growth hormone replacement therapy.
abstract: Wilms tumour was found in a Japanese boy aged 5 years 9 months with isolated growth hormone (GH) deficiency and some congenital anomalies. He had received pituitary GH replacement therapy from the age of 2 years 1 month to 4 years 7 months and after a 1 year interval he received biosynthetic GH for 2 months until the tumour became clinically apparent. This was the sixth known patient with GH deficiency to develop a malignant neoplasm during or after GH replacement therapy and the first with a solid tumour in Japan since 1975, when treatment with pituitary GH for patients with GH deficiency was introduced.
authors.affiliation: Department of Paediatrics, Kyoto University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Momoi
authors.forename: C
authors.initials: C
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Yorifuji
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Kaji
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Inomata
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Mikawa
mesh_terms: D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology; D008297:Male; D011859:Radiography; D009396:Wilms Tumor / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology
chemical_list: D013006:Growth Hormone