title: The frequency of complement receptor type 1 (CR1) gene polymorphisms in nine families with multiple cases of systemic lupus erythematosus.
abstract: Low levels of complement receptor type 1 (CR1) on the erythrocytes of patients with systemic lupus erythematosus (SLE) may be acquired or genetically determined. Nine families with multiple cases of SLE were studied using a CR1 probe and restriction fragment length polymorphism analysis, to address this question. The absence of a significant increase in the frequency of a 6.9-kb band (previously shown to be associated with low-level CR1 on erythrocytes) suggests that this genetic marker does not play a major role in determining SLE, either in these families or in SLE patients in general.
authors.affiliation: Department of Rheumatology/Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: J G
authors.initials: JG
authors.lastname: Tebib
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Granados
authors.forename: D
authors.initials: D
authors.lastname: Alarcon-Segovia
authors.forename: P H
authors.initials: PH
authors.lastname: Schur
mesh_terms: D015342:DNA Probes; D004912:Erythrocytes / Q000276:immunology*; D005819:Genetic Markers; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D009693:Nucleic Acid Hybridization; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011951:Receptors, Complement / Q000235:genetics*
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D011951:Receptors, Complement