title: The clinical utility of pharmacological agents that act at serotonin receptors.
abstract: The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.
authors.affiliation: Department of Neurology, Stanford University, CA 94305.
authors.forename: S J
authors.initials: SJ
authors.lastname: Peroutka
authors.forename: A J
authors.initials: AJ
authors.lastname: Sleight
authors.forename: B G
authors.initials: BG
authors.lastname: McCarthy
authors.forename: P A
authors.initials: PA
authors.lastname: Pierce
authors.forename: A W
authors.initials: AW
authors.lastname: Schmidt
authors.forename: C R
authors.initials: CR
authors.lastname: Hekmatpanah
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D011619:Psychotropic Drugs; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin