PEST regions, proteolysis and cell cycle progression.
How eucaryotic cells control cell division is both a major intellectual challenge and a problem of considerable medical importance. A decade of studies on oncogenes has made it abundantly clear that protein kinases play a central role in regulating mitosis. In this essay, I review a number of recent discoveries providing evidence that selective proteolysis, like phosphorylation, is an important mechanism for ordering metabolic events within the cell cycle.
Rechsteiner
M
M
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City 84132.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D006801:Humans; D008677:Metaphase; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014452:Ubiquitins / Q000378:metabolism*
D011506:Proteins; D014452:Ubiquitins; D000255:Adenosine Triphosphate; D010447:Peptide Hydrolases