title: Distal-less encodes a homoeodomain protein required for limb development in Drosophila.
abstract: The spatial organization of the Drosophila embryo depends on the activity of three axial pattern-forming systems. In addition to the anterior-posterior and dorsal-ventral systems that organize the segmented body plan, a proximal-distal pattern-forming system is required to provide positional information for the developing limbs. The development of both the larval and adult limbs depends directly on the activity of the Distal-less gene. Genetic analysis has shown that Distal-less functions as a developmental switch that is required to promote the development of limb structures above the evolutionary ground-state of body wall. Here we provide genetic evidence that indicates a graded requirement for Distal-less activity during limb development. Reduction of this activity has a global effect on pattern formation in the limb. The molecular structure of the Distal-less locus indicates that the gene encodes a homoeodomain-containing protein which is therefore likely to specify limb development through differential regulation of subordinate genes.
authors.affiliation: Max-Planck-Institut für Entwicklungsbiologie, Tübingen, FRG.
authors.forename: S M
authors.initials: SM
authors.lastname: Cohen
authors.forename: G
authors.initials: G
authors.lastname: Brönner
authors.forename: F
authors.initials: F
authors.lastname: Küttner
authors.forename: G
authors.initials: G
authors.lastname: Jürgens
authors.forename: H
authors.initials: H
authors.lastname: Jäckle
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D005121:Extremities / Q000196:embryology*; D005801:Genes, Homeobox; D008969:Molecular Sequence Data