348 cases of suspected neonatal alloimmune thrombocytopenia.
Serological and clinical data were collected in 348 cases of suspected neonatal alloimmune thrombocytopenia (NAT). Of the 144 mothers who were Zwa-negative, 107 had Zwa antibodies--alone (94); with HLA antibodies (12); or with Bra antibodies (1). Antibodies were detected in 12 of the 204 Zwa-positive mothers as follows: anti-Bra (9), anti-Zwb (1), anti-Baka with HLA antibody (1), and blood group B isoagglutinins (1). The frequency of NAT due to Bra incompatibility (19%) was second to Zwa (78%). Zwa-NAT was clinically the more severe (14% had intracranial haemorrhages) and responded well to either maternal platelet transfusions or intravenous IgG. In Bra-NAT intracranial haemorrhages were not observed and most children recovered without specific therapy.
Mueller-Eckhardt
C
C
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
Kiefel
V
V
Grubert
A
A
Kroll
H
H
Weisheit
M
M
Schmidt
S
S
Mueller-Eckhardt
G
G
Santoso
S
S
D000293:Adolescent; D000328:Adult; D016824:Antigens, Human Platelet; D001787:Blood Group Incompatibility / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000209:etiology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007231:Infant, Newborn; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange; D010976:Platelet Count; D017713:Platelet Transfusion; D011247:Pregnancy; D011379:Prognosis; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology* / Q000628:therapy
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D006680:HLA Antigens; C061248:ITGB3 protein, human; D007074:Immunoglobulin G; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens