title: Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population.
abstract: In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.
authors.affiliation: INSERM U. 91, Hôpital H. Mondor, Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Vidaud
authors.forename: A
authors.initials: A
authors.lastname: Kitzis
authors.forename: C
authors.initials: C
authors.lastname: Ferec
authors.forename: D
authors.initials: D
authors.lastname: Bozon
authors.forename: V
authors.initials: V
authors.lastname: Dumur
authors.forename: G
authors.initials: G
authors.lastname: Giraud
authors.forename: F
authors.initials: F
authors.lastname: David
authors.forename: O
authors.initials: O
authors.lastname: Pascal
authors.forename: M
authors.initials: M
authors.lastname: Auvinet
authors.forename: Y
authors.initials: Y
authors.lastname: Morel
mesh_terms: D003550:Cystic Fibrosis / Q000235:genetics*; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers