[Erythrocyte cation transport in arterial hypertension: interrelation with the renin-angiotensin-aldosterone system and the atrial natriuretic factor].
Red cell membrane Na(+)-K+ transport systems, renin-angiotensin-aldosterone system (RAAS) and atrial natriuretic factor (ANF) were studied in a group of 50 mild essential hypertensive patients (n = 25 for each group) age, sex and blood pressure matched. Na(+)-K+ ATPase and intracellular Na+ (Na+ i) were significantly different between the two groups (p less than 0.01). A slight difference was also seen for the Na(+)-K+ cotransport (p less than 0.05) as a likely consequence of the differences in the methodology of Na+ charge to study its efflux from the red cells in vitro. A negative correlation (r = -0.47, p less than 0.01) was observed between ANF and Na(+)-K+ cotransport suggesting an interrelationship of the two systems in the homeostasis in body fluid and electrolytes.
Manunta
P
P
Melis
M G
MG
Soro
A
A
Pazzola
A
A
Troffa
C
C
Motzo
S
S
Pala
F
F
Madeddu
P
P
Tonolo
G
G
Glorioso
N
N
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000493:pharmacokinetics*; D012084:Renin-Angiotensin System / Q000502:physiology*; D012964:Sodium / Q000493:pharmacokinetics*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D009320:Atrial Natriuretic Factor; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
I trasporti cationici eritrocitari nell ipertensione arteriosa: interrelazioni con il sistema renina-angiotensina-aldosterone ed il fattore atriale natriuretico.