title: Physiologic and metabolic aspects of anticonvulsants.
abstract: A great number of anticonvulsants are available for treating these different types of epilepsy. Therapeutic drug monitoring has been favored as the method for controlling drug concentrations in the plasma and preventing untoward effects. When these anticonvulsants are prescribed to treat epilepsy in children, careful monitoring is most important because drug metabolism varies depending on maturation and development of body functions. Molecular approaches are also important to elucidate the effectiveness of the drugs for treatment of different seizure disorders and should contribute to a better understanding of body functions.
authors.affiliation: Kumamoto University Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Matsuda
authors.forename: A
authors.initials: A
authors.lastname: Higashi
authors.forename: N
authors.initials: N
authors.lastname: Inotsume
mesh_terms: D000927:Anticonvulsants / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation; D001842:Bone and Bones / Q000187:drug effects; D015220:Calcium Channels / Q000187:drug effects; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D004347:Drug Interactions; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D015220:Calcium Channels; D011963:Receptors, GABA-A