Recombinant human interferon alpha-2b enhances the radiosensitivity of small cell lung cancer in vitro.
We have studied the effects of human recombinant interferon alpha on the radiobiological response and the cell cycle distribution of human small cell lung cancer cell lines. In two small cell lung cancer cell lines tested so far, pretreatment with interferon alpha was found to increase the radiation sensitivity without altering the distribution of cells in the cell cycle.
Kardamakis
D
D
Imperial Cancer Research Fund, University College, London, England.
Gillies
N E
NE
Souhami
R L
RL
Bewerley
P C
PC
D018288:Carcinoma, Small Cell; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000187:drug effects / Q000302:isolation & purification / Q000528:radiation effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D008175:Lung Neoplasms; D011838:Radiation-Sensitizing Agents; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D014410:Tumor Stem Cell Assay
D004273:DNA, Neoplasm; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011838:Radiation-Sensitizing Agents; D011994:Recombinant Proteins