A new DNA marker tightly linked to the fragile X locus (FRAXA).
The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.
Suthers
G K
GK
Department of Histopathology, Adelaide Children's Hospital, Australia.
Callen
D F
DF
Hyland
V J
VJ
Kozman
H M
HM
Baker
E
E
Eyre
H
H
Harper
P S
PS
Roberts
S H
SH
Hors-Cayla
M C
MC
Davies
K E
KE
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D005817:Genetic Counseling; D008040:Genetic Linkage; D005819:Genetic Markers; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D016013:Likelihood Functions; D051379:Mice; D016532:Mucopolysaccharidosis II / Q000235:genetics; D009154:Mutation; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014178:Translocation, Genetic
D005819:Genetic Markers