Modification of fibrous Oregon erionite and its effects on in vitro activity.
A sample of erionite, a fibrous zeolite, was modified by milling to reduce the number and length of the fibres and by extraction with cyclohexane. The in vitro activities of this mineral were found to depend on the presence of long fibres. The erionite contained fewer of these fibres than the UICC asbestos samples but, unlike these materials, erionite can cause the transformation of C3H 10T1/2 cells. Erionite did not increase the activities of benzo[a]pyrene in this cell transformation assay. The cytotoxic activities of both asbestos and erionite have a similar dependence on the number of long fibres. Extraction with cyclohexane did not affect the activity of erionite.
Brown
R C
RC
MRC Toxicology Unit, Carshalton, UK.
Davies
R
R
Rood
A P
AP
D000538:Aluminum Silicates / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000209:etiology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009922:Oregon; D010316:Particle Size; D017641:Zeolites
D000538:Aluminum Silicates; D002273:Carcinogens; D017641:Zeolites