A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus.
Linkage analysis of five marker loci in and around the Duchenne muscular dystrophy (DMD) locus, DXS84, DXS206, DXS164, DXS270, and DXS28, was conducted with 499 families. Overall, the best multipoint distances were found to be DXS84-3.7 +/- 0.6 cM-DXS206-1.0 +/- 0.4 cM-DXS164-1.9 +/- 0.6 cM-DXS270-12.0 +/- 1.1 cM-DXS28. A comparison of this linkage map with the established physical map suggests the presence of hot spots for recombination in the DMD locus.
Chen
J D
JD
Prince of Wales Hospital, University of New South Wales, Sydney, Australia.
Hejtmancik
J F
JF
Romeo
G
G
Lindlof
M
M
Boehm
C
C
Caskey
C T
CT
Kress
W
W
Fischbeck
K H
KH
Dreier
M
M
Serravalle
S
S
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D014960:X Chromosome
D005819:Genetic Markers