Isolated ACTH deficiency associated with transient thyrotoxicosis and hyperprolactinemia.
A 43-year-old woman with isolated ACTH deficiency in association with transient thyrotoxicosis is reported. The initial evaluation revealed that plasma ACTH and cortisol did not respond to corticotropin-releasing hormone (CRH) in the presence of hyperthyroxinemia and hyperprolactinemia. During the replacement therapy with dexamethasone, she developed transient hypothyroxinemia with persistent hyperprolactinemia. Although thyroid open biopsy did not show any evidence of autoimmune thyroiditis or subacute thyroiditis, the data appear to provide other evidence of a possible relationship between acute adrenal insufficiency and transient thyroid dysfunction.
Kanemaru
Y
Y
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Noguchi
T
T
Onaya
T
T
D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000328:Adult; D003346:Corticotropin-Releasing Hormone; D003366:Cosyntropin; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D007328:Insulin; D008236:Lypressin; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology; D013971:Thyrotoxicosis / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors
D007328:Insulin; D003366:Cosyntropin; D007987:Gonadotropin-Releasing Hormone; D008236:Lypressin; C006418:adrenocorticotropin zinc; D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone