Determination of the lysosomal role in tumor accumulation of 67Ga by dual-tracer studies.
The lysosomal role in tumor accumulation of 67Ga was determined by dual-tracer (67Ga and 46Sc) studies. It became clear that 67Ga essentially did not accumulate in the tumor lysosome, and that the lysosome did not play a major role in tumor accumulation of 67Ga. In addition, it was revealed that tumor lysosome was hardly disrupted at all in some phases of fractionation procedures.
Ando
A
A
School of Allied Medical Professions, Kanazawa University, Japan.
Ando
I
I
Hiraki
T
T
Yamada
N
N
Hisada
K
K
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging*; D002951:Citrates / Q000493:pharmacokinetics*; D019343:Citric Acid; D008247:Lysosomes / Q000378:metabolism*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012517:Sarcoma, Yoshida / Q000000981:diagnostic imaging*; D012538:Scandium / Q000493:pharmacokinetics
D002951:Citrates; D011868:Radioisotopes; D019343:Citric Acid; D012538:Scandium