title: Tyrosine hydroxylase and levodopa responsive dystonia.
abstract: It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.
authors.affiliation: Department of Clinical Neurology, Institute of Neurology, London, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Fletcher
authors.forename: I J
authors.initials: IJ
authors.lastname: Holt
authors.forename: A E
authors.initials: AE
authors.lastname: Harding
authors.forename: T G
authors.initials: TG
authors.lastname: Nygaard
authors.forename: J
authors.initials: J
authors.lastname: Mallet
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D004421:Dystonia / Q000188:drug therapy / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D015342:DNA Probes; D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase