Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension.
20 patients with mild hypertension (average supine blood pressure without treatment, 164/101 mm Hg) reduced their salt intake to 50 mmol (3 g) per day for a month. They then entered a 3 month double-blind randomised crossover study of three levels of sodium intake: 200, 100, and 50 mmol per day. Blood pressure was significantly reduced on the middle and lowest sodium intakes. The average fall in blood pressure from the highest to the lowest sodium intake was 16/9 mm Hg. Patients continued to restrict their sodium intake for a further year. In 16 of the 20 patients blood pressure remained well controlled with salt restriction alone. Supine blood pressure at 1 year was 142/87 (SE 3/2) mm Hg with a 24 h urinary sodium excretion of 54 (7) mmol. These results show a progressive blood pressure fall as salt intake is reduced and that, in many patients with mild essential hypertension, blood pressure can be controlled without the need for drug therapy.
MacGregor
G A
GA
Department of Medicine, St George's Hospital Medical School, London.
Markandu
N D
ND
Sagnella
G A
GA
Singer
D R
DR
Cappuccio
F P
FP
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D003692:Delayed-Action Preparations; D004039:Diet, Sodium-Restricted; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D016032:Randomized Controlled Trials as Topic; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets