[Clinical relevance of determining lymphocyte subpopulations in peripheral blood of patients with rheumatoid arthritis].
Blood lymphocytes were determined from 21 patients with seropositive rheumatoid arthritis (RA) in a cross-sectional study with 5 monoclonal antibodies (MAb) of the BL-series. 7 patients were examined with the same MAb over a time period of 14 weeks before and after a prednisolone-pulse therapy. The cross-sectional study showed a significant higher percentage of Ia4+ T-helper/inducer-lymphocytes in RA-patients compared to control persons. The value of Ia4+ T-lymphocytes didn't correlate to the clinical activity of the RA. No significant differences were observed in the helper/suppressor T-lymphocyte ratio. The lymphocyte subpopulations were not significantly different immediately before and after a prednisolone-pulse therapy. The percentage of B-lymphocytes was significantly higher in comparison to the controls 24 h after prednisolone-pulse therapy. An immunomonitoring of the clinical activity and the therapy of RA is not possible with the used MAb.
Hempel
M
M
Abteilung für Medizinische Immunologie, Medizinischen Akademie Erfurt.
Wietschel
F
F
Malberg
K
K
Kästner
P
P
D000328:Adult; D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D006684:HLA-DR Antigens; D011239:Prednisolone
Klinische Wertigkeit der Bestimmung von Lymphozytensubpopulationen im peripheren Blut von Patienten mit Rheumatoid-Arthritis (RA).