title: Prevention of aflatoxicosis by addition of hydrated sodium calcium aluminosilicate to the diets of growing barrows.
abstract: Hydrated sodium calcium aluminosilicate (HSCAS), an anticaking agent for mixed feed, was added to the diets of growing barrows and was evaluated for its potential to ameliorate the clinical signs of aflatoxicosis. The experimental design consisted of 6 treatments of 5 barrows each at concentrations of 0 g of HSCAS and 0 g of aflatoxin (AF)/kg of feed (control), 5 g of HSCAS/kg of feed (0.5%), 20 g of HSCAS/kg of feed (2.0%), 3 mg of AF/kg of feed, 5 g of HSCAS (0.5%) plus 3 mg of AF/kg of feed, or 20 g of HSCAS (2.0%) plus 3 mg of AF/kg of feed. Barrows were maintained in indoor concrete-floored pens, with feed and water available ad libitum for 28 days (from the age of 7 to 11 weeks). Barrows were observed twice daily and were weighed weekly, and blood samples were obtained weekly for hematologic and serum biochemical measurements. At the termination of the study, barrows were euthanatized and necropsied. Body weight gains were diminished significantly (P less than 0.05) by consumption of 3 mg of AF/kg of feed, whereas body weight gain in barrows consuming diets containing HSCAS or HSCAS plus AF did not differ from that in control barrows. Serum enzymatic activities of alkaline phosphatase and gamma-glutamyl transferase and prothrombin time were increased in barrows consuming 3 mg of AF/kg of feed, but not in those consuming HSCAS or HSCAS plus AF.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: USDA Agricultural Research Service, Veterinary Toxicology and Entomology Research Laboratory, College Station, TX 77841.
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: T D
authors.initials: TD
authors.lastname: Phillips
authors.forename: W E
authors.initials: WE
authors.lastname: Huff
authors.forename: D E
authors.initials: DE
authors.lastname: Corrier
mesh_terms: D000538:Aluminum Silicates / Q000627:therapeutic use*; D000821:Animal Feed; D000818:Animals; D001231:Aspergillus flavus; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009145:Mushroom Poisoning / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000517:prevention & control*; D013950:Thymus Gland / Q000473:pathology; D015430:Weight Gain; D017641:Zeolites; D000096702:Aflatoxin Poisoning
chemical_list: D000538:Aluminum Silicates; D017641:Zeolites