title: [Lipid peroxidation and ATPase activity in synaptosomal and mitochondrial fractions of the brain in hypoxia].
abstract: Acute hypoxia was accompanied by intensification of lipid peroxidation in synaptosomal and mitochondrial rat brain fractions as well as by inhibition of Na+, K+- and Mg2+-ATPases. Preadministration of antioxidants vitamin E and ionol into animals prevented distinctly the increase in lipid peroxidation rate, while the ATPases activity was unaltered. Inhibition of the ATPases may be considered as a result of impairing effect of the lipid peroxidation products, which appears to be of importance for structure-functional deteriorations of the nervous system in hypoxia.
authors.forename: A I
authors.initials: AI
authors.lastname: Dzhafarov
authors.forename: N M
authors.initials: NM
authors.lastname: Magomedov
authors.forename: Kh F
authors.initials: KhF
authors.lastname: Babaev
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Akhmedova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Bekhbudova
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation; D008928:Mitochondria / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology*
chemical_list: D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Perekisnoe okislenie lipidov i aktivnost' ATFaz v sinaptosomal'nykh i mitokhondrial'nykh fraktsiiakh mozga pri gipoksii.