Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids. III.
Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated.
Nikaido
T
T
Ohmoto
T
T
Kinoshita
T
T
Sankawa
U
U
Delle Monache
F
F
Botta
B
B
Tomimori
T
T
Miyaichi
Y
Y
Shirataki
Y
Y
Yokoe
I
I
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005419:Flavonoids; D015105:3',5'-Cyclic-AMP Phosphodiesterases