Amylinamide, bone conservation, and pancreatic beta cells.
Amylinamide is a potent osteoclast-inhibiting peptide that is co-secreted with insulin from the beta cell. It induces profound hypocalcaemia in rats and rabbits and abolishes bone resorption by isolated osteoclasts in vitro. The non-amidated human peptide forms an insoluble fibrillar amyloid deposit that may interfere with beta-cell function and precipitate type II diabetes.
MacIntyre
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Department of Chemical Pathology, Royal Postgraduate Medical School, London.
D000682:Amyloid / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D001862:Bone Resorption; D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D011817:Rabbits; D051381:Rats
D000682:Amyloid; D007328:Insulin; C060605:amylinamide; D002117:Calcitriol; D002118:Calcium