Bidirectional transfer between kindling induced either by L-glutamate or L-aspartate and electrical stimulation in rats.
Repeated spaced injections into the amygdala (AM) of rats of a subconvulsive dose of either L-glutamate (GLU) or L-aspartate (ASP) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled seizure. Both GLU- and ASP-kindled AM sites responded to electrical stimulation with very rapid development of kindled seizure. When electrically kindled AM sites received identical injections of GLU or ASP, a similar positive transfer effect was obtained. These results suggest that (1) either GLU or ASP alone can kindle the AM and (2) GLU, ASP or GLU/ASP kindling share common neurobiological mechanisms with electrical kindling.
Mori
N
N
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Wada
J A
JA
Kumashiro
H
H
D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D001224:Aspartic Acid / Q000633:toxicity*; D004558:Electric Stimulation; D005971:Glutamates / Q000633:toxicity*; D018698:Glutamic Acid; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid