title: Effect of bromobenzene and O-bromophenol on kidney and liver of English sole (Parophrys vetulus).
abstract: 1. English sole (Parophrys vetulus) were injected intraperitoneally with a single dose of 9.8 mmol bromobenzene/kg of fish or 1.9 mmol O-bromophenol/kg of fish, both known renal toxicants in mammals. 2. Kidney, liver, gill spleen, intestines, heart and blood samples were subsequently obtained up to 48 hr post-injection for determination of microscopic lesions, concentrations of selected tissue antioxidants (glutathione and ascorbic acid), and selected serum parameters. 3. Bromobenzene and O-bromophenol were both found to be hepatotoxic in English sole, as indicated by the presence of hepatocellular coagulation necrosis and fatty change in the liver, altered glutathione and ascorbic acid levels in liver tissue, elevated serum aspartate aminotransferase and alkaline phosphatase activity and increased serum glucose and triglyceride levels. 4. No evidence of nephrotoxicity was found in English sole exposed to either toxicant. 5. It is concluded that bromobenzene and O-bromophenol cannot be used as model nephrotoxicants but can be used as hepatotoxicants in English sole.
authors.affiliation: Northwest and Alaska Fisheries Center, Environmental Conservation Division, Seattle, WA 98112.
authors.forename: E
authors.initials: E
authors.lastname: Casillas
authors.forename: M S
authors.initials: MS
authors.lastname: Myers
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001969:Bromobenzenes / Q000633:toxicity*; D005412:Flatfishes / Q000097:blood*; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009928:Organ Specificity; D010084:Oxidation-Reduction; D010636:Phenols / Q000633:toxicity*; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001969:Bromobenzenes; D010636:Phenols; D014280:Triglycerides; C032038:2-bromophenol; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D005978:Glutathione; D001205:Ascorbic Acid