Preferential expression of cellular retinoic acid binding protein in a subpopulation of neural cells in the developing mouse embryo.
The cellular retinoic acid binding protein is thought to be involved in the retinoic-acid-mediated signal transduction pathway. We have isolated the mouse cellular retinoic acid binding protein cDNA from an embryonal-carcinoma-derived cell line by using differential cDNA cloning strategies. In situ hybridization on sections of mouse embryos of various developmental stages indicated that the cellular retinoic acid binding protein gene, which we localized on mouse chromosome 9, is preferentially expressed in a subpopulation of neurectodermal cells. This restricted expression pattern suggests an important role for cellular retinoic acid binding protein in murine neurogenesis.
Vaessen
M J
MJ
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
Kootwijk
E
E
Mummery
C
C
Hilkens
J
J
Bootsma
D
D
van Kessel
A G
AG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology*; D009474:Neurons / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics; D018168:Receptors, Retinoic Acid; D015183:Restriction Mapping; D014212:Tretinoin / Q000378:metabolism*
D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D004247:DNA