title: The excretion of prostacyclin (PGI2) in milk and its possible role as a vasodilator in the mammary gland of goats.
abstract: 1. Prostacyclin production in mammary gland of two lactating goats measured as the excretion in milk of 6-ketoprostaglandin F1 alpha (6-KPGF1 alpha) was followed for 16 days before, during and after exogenous administration of recombinant bovine growth hormone (GH). 2. 6-KPGF1 alpha was detected in all milk samples in concentrations ranging from 32-99 pg/ml milk independently of the time of sampling. 3. GH-treatment significantly increased milk yield, the concentration and excretion of 6-KPGF1 alpha in milk. 4. The concentration of milk 6-KPGF1 alpha was positively correlated with milk yield in the high (R2 = 0.35), but not in the low yielding goat (R2 = 0.003). 5. The possible role of prostacyclin as a local vasodilator in the mammary gland of goats is discussed.
authors.affiliation: Royal Veterinary and Agricultural University, Department of Animal Physiology and Biochemistry, Frederiksberg, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Christensen
authors.forename: M O
authors.initials: MO
authors.lastname: Nielsen
authors.forename: N
authors.initials: N
authors.lastname: Jarløv
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D011464:Epoprostenol / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006041:Goats / Q000502:physiology*; D013006:Growth Hormone / Q000494:pharmacology; D007774:Lactation / Q000502:physiology; D008321:Mammary Glands, Animal / Q000098:blood supply*; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D013223:Statistics as Topic; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D015121:6-Ketoprostaglandin F1 alpha; D013006:Growth Hormone; D011464:Epoprostenol