[Effects of opioid receptor ligands on DNA synthesis and histamine contents in the gastric mucosa and blood of white rats].
Using autoradiographic study with 3H-thymidine and spectrofluorometric method the authors studied the influence of opioid receptors' ligands on the DNA synthesis in the stomach epithelium histamine content and the blood. Leu-encephalin, B-endorphin, dalargin, napoxone were administered intraperitoneally to male rats. The dose of injection was 0.1 ml per 100 g body weight. It was observed that B-endorphin and dalargin 1.5-1.6 fold increased the quantity of DNA-synthesised nuclei in the epithelium of fundal stomach section. Leu-encephalin and dalargin increased the histamine concentration in the stomach, at the same time dalargin caused a rapid decrease of histamine concentration in the blood. Naloxone also decreased histamine concentration in the stomach. The obtained results are being discussed in connection with dalargin therapy of ulcerous diseases.
Aleksandrovich
A G
AG
Zhdanova
T F
TF
Timoshin
S S
SS
Uchakina
R V
RV
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005753:Gastric Mucosa / Q000032:analysis*; D006632:Histamine / Q000032:analysis* / Q000097:blood; D008024:Ligands; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*; D013050:Spectrometry, Fluorescence
D000897:Anti-Ulcer Agents; D008024:Ligands; D011957:Receptors, Opioid; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D006632:Histamine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie ligandov opioidnykh retseptorov na sintez DNK i soderzhanie gistamina v slizistoĭ zheludka i krovi belykh krys.