title: Alterations of cholesterol synthesis precursors (7-dehydrocholesterol, 7-dehydrodesmosterol, desmosterol) in dysmyelinating neurological mutant mouse (quaking, shiverer and trembler) in the PNS and the CNS.
abstract: In brain, levels of cholesterol, desmosterol and 7-dehydrodesmosterol are reduced in shiverer and quaking, but not in trembler 60-day-old dysmyelinating mutant mice. Very interestingly, 7-dehydrocholesterol is not altered in any mutant. The amount of cholesterol is similar in the different normal control mouse strains and in rat. In contrast, levels of precursors are not the same. In sciatic nerve, cholesterol is slightly reduced in shiverer, reduced 2-fold in quaking, and dramatically reduced in trembler (10-fold). 7-Dehydrocholesterol is affected in all mutants.
authors.affiliation: INSERM Unité 26, Hôpital Fernand Widal, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
authors.forename: M
authors.initials: M
authors.lastname: Clément
authors.forename: D
authors.initials: D
authors.lastname: Gérard
authors.forename: J
authors.initials: J
authors.lastname: Chaudiére
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002762:Cholecalciferol / Q000378:metabolism* / Q000031:analogs & derivatives; D002775:Cholestadienols / Q000378:metabolism*; D003684:Dehydrocholesterols / Q000378:metabolism*; D003897:Desmosterol / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants; D010525:Peripheral Nerves / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000378:metabolism; D013045:Species Specificity
chemical_list: D002775:Cholestadienols; D003684:Dehydrocholesterols; C007041:cholesta-5,7,24-trien-3 beta-ol; D002762:Cholecalciferol; D003897:Desmosterol; C016705:7-dehydrocholesterol