[The effect of a single dose of dexamethasone on the production of superoxide anion and on the chemotaxis of blood polynuclear neutrophils in the horse].
Chemotaxis and superoxide anion production of neutrophils in healthy horses were investigated before and 8 h after, a single injection of dexamethasone at a dose of 0.045 mg/kg. Chemotaxis was studied by the technique of migration under agarose and superoxyde production was measured by ferricytochrome c reduction. Superoxide anion production was not changed, but the chemotactic index, with zymosan activated horse serum, was increased. The FMLP chemoattractant effect, at 10(-4) M, was slightly enhanced.
Guelfi
J F
JF
Laboratoire d'Exploration Fonctionnelle INRA-ENVT, Toulouse, France.
Kraouchi
D E
DE
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006736:Horses / Q000097:blood*; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003907:Dexamethasone
Effets d'une dose unique de dexamethasone sur la production d'anion superoxyde et sur le chimiotactisme des polynucleaires neutrophiles sanguins du cheval.