Effects of bethanechol and adreno-blockers on thermoregulation in spinal cord injury.
The authors report two cases of hypothermia due to a treatment associating Bethanechol and Adreno-Blockers. They emphasize the mechanisms of thermoregulation and discuss the pathophysiology of such hypothermia incidents. The most evident explanation is heat loss, principally mediated through Bethanechol, whereas mechanisms of heat preservation are prevented by Adreno-Blockers. Patients susceptible to this risk must be carefully monitored.
Berard
E J
EJ
Spinal Cord Injury Unit, Hospital Renée Sabran, Giens-Hyeres, France.
Boucand
M H
MH
Depassio
J
J
Fyon
J P
JP
D000328:Adult; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D001833:Body Temperature Regulation / Q000187:drug effects; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D010643:Phenoxybenzamine / Q000009:adverse effects / Q000627:therapeutic use; D011782:Quadriplegia / Q000150:complications*; D011799:Quinazolines / Q000009:adverse effects / Q000627:therapeutic use; D013119:Spinal Cord Injuries / Q000150:complications*; D013565:Sympatholytics / Q000009:adverse effects* / Q000627:therapeutic use; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology
D001626:Bethanechol Compounds; D011799:Quinazolines; D013565:Sympatholytics; D018723:Bethanechol; D010643:Phenoxybenzamine; C047638:alfuzosin