title: A clinical study into the possible intrinsic bradycardic activity of vecuronium.
abstract: Forty female patients received a standardised anaesthetic technique with thiopentone sodium and enflurane. Half of the patients received, under double-blind conditions, either physiological saline or glycopyrronium before induction of anaesthesia; 10 minutes after induction of anaesthesia, all patients received vecuronium 0.1 mg/kg. A further 10 patients received neither glycopyrronium nor vecuronium. The results show that vecuronium per se does not produce a decrease in heart rate.
authors.affiliation: Surgical Hospital, Helsinki, Finland.
authors.forename: D A
authors.initials: DA
authors.lastname: Cozanitis
authors.forename: O
authors.initials: O
authors.lastname: Erkola
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004311:Double-Blind Method; D004737:Enflurane; D005260:Female; D006024:Glycopyrrolate; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D014673:Vecuronium Bromide; D004737:Enflurane; D006024:Glycopyrrolate