Group A streptococci bind human plasmin but not other structurally related proteins.
Certain group A streptococci are known to possess a receptor for the human enzyme plasmin. Plasmin is a member of a super gene family that includes other serine proteases and kringle containing proteins. In this study we have examined the interaction of a group A streptococcus with structurally related proteins, including plasmin, glu-plasminogen, tissue plasminogen activator, kallikrein, factor XII, prothrombin, thrombin, trypsin, and urokinase. Our studies indicate that only the key fibrinolytic enzyme, plasmin, demonstrates significant binding activity to the group A streptococcus.
DesJardin
L E
LE
Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville 32610.
Boyle
M D
MD
Lottenberg
R
R
D000818:Animals; D004792:Enzyme Precursors / Q000378:metabolism; D005341:Fibrinolysin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D005810:Multigene Family; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding; D012697:Serine Endopeptidases / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000378:metabolism*
D004792:Enzyme Precursors; D010446:Peptide Fragments; D012697:Serine Endopeptidases; D005341:Fibrinolysin