A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis.
A sicca syndrome with parotid enlargement, pulmonary insufficiency, and lymphadenopathy was seen in 12 patients infected with human immunodeficiency virus (HIV), only 1 of whom has had an opportunistic infection during 304 patient months of study. There was a striking increase in numbers of circulating CD8 lymphocytes and the prevalence of HLA-DR5 was greatly increased. In patients with this diffuse infiltrative lymphocytosis syndrome (DILS) the CD8 lymphocytosis, which probably depends on histocompatibility antigen status, may influence disease progression in HIV infection.
Itescu
S
S
Hospital for Joint Diseases, New York, NY 10003.
Brancato
L J
LJ
Winchester
R
R
D000386:AIDS-Related Complex / Q000150:complications / Q000235:genetics*; D000328:Adult; D000911:Antibodies, Monoclonal; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D005500:Follow-Up Studies; D006684:HLA-DR Antigens / Q000032:analysis*; D015805:HLA-DR5 Antigen; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology; D008218:Lymphocytosis / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000209:etiology; D012307:Risk Factors; D012469:Salivary Glands / Q000166:cytology; D013577:Syndrome; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology*; D014985:Xerophthalmia / Q000209:etiology*; D014987:Xerostomia / Q000209:etiology*
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D015805:HLA-DR5 Antigen