title: Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical alpha 1-adrenoceptors.
abstract: Chronic administration of mianserin induced an increase in the density of [3H] prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat brain cortical alpha 1-adrenoceptors may depend on the characteristics of the drug used.
authors.affiliation: Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sallés
authors.forename: E
authors.initials: E
authors.lastname: Claro
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: F
authors.initials: F
authors.lastname: Picatoste
authors.forename: A
authors.initials: A
authors.lastname: Badia
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D011530:Protriptyline / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013997:Time Factors
chemical_list: D003986:Dibenzocycloheptenes; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D008803:Mianserin; D011530:Protriptyline; D009638:Norepinephrine; D011224:Prazosin