Antithrombotic effect of thiopurinol.
Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formation in the cat. Thiopurinol inhibited aggregation of platelets induced by ADP and arachidonic acid but did not inhibit superoxide generation. It had no antiinflammatory activity nor any effect on cardiovascular system. The results indicate that the antithrombotic activity of the compound is mediated via inhibition of platelet aggregation.
Srivastava
R
R
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
Mishra
A
A
Pratap
R
R
Bhakuni
D S
DS
Srimal
R C
RC
D000493:Allopurinol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005112:Extracorporeal Circulation; D005609:Free Radicals; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects; D013481:Superoxides; D014528:Uricosuric Agents / Q000627:therapeutic use*
D005609:Free Radicals; D010975:Platelet Aggregation Inhibitors; D014528:Uricosuric Agents; D013481:Superoxides; D000493:Allopurinol; C005832:tisopurine; D007213:Indomethacin