[Short scientific report. Vitamin C lessens superoxide anion(O2)-induced bronchial constriction].
An in vivo model of acute lung damage provoked by free oxygen radicals in guinea pigs was introduced. Bronchial and pulmonary response was induced by tracheal instillation of Xanthine-Oxidase (XO)-Xanthine solution. The response was measured as a decrease of tidal volume during unchanged artificially ventilation. It was found that ascorbic acid pretreatment was effective to diminish the XO-induced reaction.
Becher
G
G
Forschungsinstitut für Lungenkrankheiten und Tuberkulose Berlin-Buch/DDR.
Winsel
K
K
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001980:Bronchi / Q000473:pathology*; D005609:Free Radicals; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology*; D013481:Superoxides / Q000494:pharmacology*; D014969:Xanthine Oxidase; D014970:Xanthines
D005609:Free Radicals; D014970:Xanthines; D013481:Superoxides; D014969:Xanthine Oxidase; D001205:Ascorbic Acid
Kurze wissenschaftliche Mitteilung. Vitamin C vermindert die superoxid-anion(O2)-induzierte bronchokonstriktion.