title: In vitro postantibiotic effect of daptomycin (LY146032) against Enterococcus faecalis and methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains.
abstract: The suppression of bacterial growth that persists after brief exposure to antimicrobial agents has been termed the postantibiotic effect (PAE). This pharmacodynamic interaction varies for each microorganism-antimicrobial agent combination. Daptomycin (LY146032) is a new lipopeptide antibiotic with activity against gram-positive organisms. We studied the in vitro bactericidal activities and PAEs of the following drugs: daptomycin compared with penicillin G and vancomycin, without and with gentamicin against Enterococcus faecalis strains; daptomycin compared with nafcillin and vancomycin against methicillin-susceptible Staphylococcus aureus strains; and daptomycin compared with vancomycin against methicillin-resistant S. aureus strains. Daptomycin, alone and when used in combination with gentamicin, exhibited greater bactericidal activity and in general produced a longer PAE than standard effective regimens against the organism strains studied.
authors.affiliation: Division of Infectious Diseases, Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: L M
authors.initials: LM
authors.lastname: Bush
authors.forename: J A
authors.initials: JA
authors.lastname: Boscia
authors.forename: M
authors.initials: M
authors.lastname: Wendeler
authors.forename: P G
authors.initials: PG
authors.lastname: Pitsakis
authors.forename: D
authors.initials: D
authors.lastname: Kaye
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin; D013293:Enterococcus faecalis / Q000187:drug effects*; D008712:Methicillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D010455:Peptides / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin; D008712:Methicillin