[Antiviral effect of mangiferin and isomangiferin on herpes simplex virus].
Using tissue culture techniques the present study assured us of the merits of mangiferin and isomangiferin in the antiviral action against HSV-1. Utilizing 4 main patterns for evaluating drug effectiveness (ie intratube drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by logarithm determination of HSV-I inhibition that isomangiferin was superior to such control drugs as acyclovir, idoxuridine, and cyclocytidine in logarithm by 0.27-0.50, and that mangiferin was lower than isomangiferin in logarithm by 0.53. The average plaque reduction rates of mangiferin and isomangiferin were 69.5% and 56.8%, respectively. All in all, the antiviral effect of mangiferin and isomangiferin was attributed presumably to their capability to inhibit virus replication within cells.
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D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D005333:Fetus / Q000166:cytology; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D000998:Antiviral Agents; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; C061492:isomangiferin