[The role of the endothelium in the beta-adrenergic regulation of vascular tonus].
The effects of beta-adrenoreceptors agonists and antagonists on vascular tone were studied. Activation of beta-adrenoreceptors led to vasomotor reaction irrespective of the endothelium, through a direct effect on the smooth muscle elements of the vascular wall. The dilating effect of propranolol is determined by its interaction with endothelial cells which leads to the PGI2 and, perhaps, EDRF release.
Akopov
S E
SE
Tumasian
K S
KS
Gabrielian
E S
ES
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol
O roli éndoteliia v beta-adrenergicheskoĭ reguliatsii sosudistogo tonusa.