title: [Partial deficiency in 21-hydroxylase in certain forms of hirsutism].
abstract: The ACTH test is important when hirsutism occurs in women with a slight 21-hydroxylase deficiency, and normal basal 17-OH Progesterone (17-OH-P/plasma levels). Extensive hormonal assays: LH, FSH, Prolactin, 17 beta-estradiol (E2), Estrone, 17OH-P, Androstenedione, Testosterone, Cortisol (C), Dehydroepiandrosterone-S (DEA-S) were carried out in 36 hirsute women. 13 of these presented hormone levels as found in polycystic ovary syndrome (PCOS), 6 women presented a slight 21-hydroxylase deficiency (increased plasma 17-OH-P and decreased C after ACTH test with significant, p less than 0.01, increase of 17-OH-P/C and 17 women presented idiopathic hirsutism (IH). The hormonal pattern, in the basal condition, is not different in IH or in slight 21-hydroxylase deficiency. The ACTH test is able to differentiate between IH and adrenal hirsutism.
authors.affiliation: Istituto di Clinica Ostetrica e Ginecologia U. C. S. C., Roma.
authors.forename: A
authors.initials: A
authors.lastname: Lucisano
authors.forename: M A
authors.initials: MA
authors.lastname: Satta
authors.forename: R
authors.initials: R
authors.lastname: Tripodi
authors.forename: L
authors.initials: L
authors.lastname: Mobili
authors.forename: F
authors.initials: F
authors.lastname: De Cicco
authors.forename: F
authors.initials: F
authors.lastname: Monaco
authors.forename: S
authors.initials: S
authors.lastname: Dell'Acqua
authors.forename: J
authors.initials: J
authors.lastname: Roche
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000728:Androgens / Q000097:blood; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000201:enzymology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006908:Hydroxyprogesterones / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood; D013250:Steroid Hydroxylases / Q000172:deficiency*
chemical_list: D000728:Androgens; D004967:Estrogens; D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013250:Steroid Hydroxylases; D006854:Hydrocortisone
vernacular_title: A propos du déficit partiel en 21-hydroxylase dans certaines formes d'hirsutisme.