title: FIA determination of chlorhexidine by means of the precipitation with Cu(II).
abstract: The determination of chlorhexidine in pharmaceutical formulations is carried out using flow injection analysis (FIA) with measurement by atomic absorption spectrometry (AAS). The method is based on the formation of a copper-biguanide complex precipitate when the sample is injected into an ammoniacal copper solution. The precipitate is retained on a plastic or paper filtering device. A nitric acid stream dissolves the precipitate and carried the Cu(II) to the AAS detector. The chlorhexidine is determined over the range 5-20 ppm. The influence of interfering substances is investigated.
authors.affiliation: Departamento de Quimica Analitica, Facultad de C. Quimicas, Universidad de Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martinez Calatayud
authors.forename: J V
authors.initials: JV
authors.lastname: Garcia Mateo
mesh_terms: D001645:Biguanides; D002710:Chlorhexidine / Q000032:analysis*; D003300:Copper; D007202:Indicators and Reagents; D009566:Nitrates; D017942:Nitric Acid; D000644:Quaternary Ammonium Compounds; D013054:Spectrophotometry, Atomic
chemical_list: D001645:Biguanides; D007202:Indicators and Reagents; D009566:Nitrates; D000644:Quaternary Ammonium Compounds; D017942:Nitric Acid; D003300:Copper; D002710:Chlorhexidine