title: [Protein S-100 in spontaneous soft tissue and peripheral nerve neoplasms in rats].
abstract: 16 spontaneous tumors of the peripheral nerves and 18 spontaneous tumors of mesenchymal origin in BDVI rats were studied by peroxidase-antiperoxidase method using anti-serum (DAKOPATT) against protein S-100. The majority of spontaneous peripheral nerve tumors were of cystic histological structure identical to that of cystic neurinomas induced in rats by ethylnitrosourea and almost all of these tumors were S-100 protein positive. The incidence of spontaneous neurinomas in BDVI rats was in some experiments as high as 5%. All tumors of mesenchymal origin (except one lipoma) were S-100 protein negative: 2 fibromas, 6 fibrosarcomas, 3 malignant fibrous histiocytomas, one rhabdomyosarcoma and one hemangioendothelioma. S-100 protein is found, as in human pathology, useful for distinguishing tumors of schwann cell and mesenchymal origin in rats.
authors.forename: V S
authors.initials: VS
authors.lastname: Turusov
mesh_terms: D000818:Animals; D005350:Fibroma / Q000032:analysis; D005354:Fibrosarcoma / Q000032:analysis; D006390:Hemangioendothelioma / Q000032:analysis; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis; D007150:Immunohistochemistry; D009463:Neuroma / Q000032:analysis; D010524:Peripheral Nervous System Neoplasms / Q000032:analysis*; D051381:Rats; D012208:Rhabdomyosarcoma / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis*; D012983:Soft Tissue Neoplasms / Q000032:analysis*
chemical_list: D009418:S100 Proteins
vernacular_title: Belok S-100 v spontannykh opukholiakh miagkikh tkaneĭ i perifericheskikh nervov krys.