Sugar modified oligonucleotides. I. Carbo-oligodeoxynucleotides as potential antisense agents.
For the first time, carbo-oligodeoxynucleotides, namely c-dT4 and c-dT12, have been synthesized. As compared to the natural oligomers these carbo-oligodeoxynucleotides are at least 5 times more stable toward enzymatic degradation and bind more strongly to complementary DNA. These preliminary data indicate that such oligomers fulfill the requirements to be considered as potential antisense agents.
Perbost
M
M
Université de Montpellier II, UA 488, CNRS, France.
Lucas
M
M
Chavis
C
C
Pompon
A
A
Baumgartner
H
H
Rayner
B
B
Griengl
H
H
Imbach
J L
JL
D001482:Base Composition; D002241:Carbohydrates; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D013816:Thermodynamics
D002241:Carbohydrates; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010727:Phosphoric Diester Hydrolases