[AIDS and sleep disorders: effect of gp120 on cerebral glucose metabolism].
The neurological complications associated with infection by the AIDS virus, HIV, occurs at an early stage of the disease and often indicate a poor prognosis. A dementia, known as AIDS Dementia Complex, is the most common feature observed, and is found in a majority of patients. The effects of gp120, the external protein envelope of HIV, on cerebral glucose utilization were studied in rats. Intracerebroventricular injection of gp120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus, two regions rich in receptors for Vasoactive Intestinal Peptide (VIP) and the whole brain metabolism showed a significant decrease. The findings suggest that gp120 may alter neuronal function, thereby contributing to sequelae of HIV infection of the brain, and that attachment of HIV particles may involve, for a part, VIP receptors.
Raymon
L P
LP
NIDA-Addiction Research Center, Baltimore, MD 21224.
Kimes
A S
AS
Tabakoff
B
B
London
E D
ED
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000008:administration & dosage / Q000494:pharmacology*; D015497:HIV-1; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012893:Sleep Wake Disorders / Q000209:etiology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D015699:HIV Envelope Protein gp120; D014660:Vasoactive Intestinal Peptide; D005947:Glucose
SIDA et troubles du sommeil: effet du gp120 sur le métabolisme cérébral du glucose.