Regression models for time to seroconversion following experimental bovine leukaemia virus infection.
This paper develops a parametric model for time to seroconversion after experimental bovine leukaemia virus (BLV) infection, and examines the effects of inoculation route, volume of inoculum, type of inoculation material, and antigen status of donor on seroconversion time. We used parametric and nonparametric statistical methodology to analyse interval data on 150 animals from 13 published reports. The log-logistic model fitted the observed times to seroconversion better than the log-normal or Weibull models, which were the considered alternatives.
Lassauzet
M L
ML
Department of Medicine, School of Veterinary Medicine, University of California, Tulare 93274.
Johnson
W O
WO
Thurmond
M C
MC
D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000276:immunology*; D001909:Leukemia Virus, Bovine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000175:diagnosis* / Q000276:immunology* / Q000635:transmission; D015233:Models, Statistical; D012044:Regression Analysis; D012190:Retroviridae / Q000276:immunology*; D012698:Serologic Tests; D013997:Time Factors