title: Adult Wilms' tumor. Role of combined modality treatment.
abstract: Adults Wilms' tumor, unlike its pediatric counterpart, is extremely rare and highly lethal. Less than 200 cases have been reported in the world literature and a large proportion of these may not have been true Wilms' tumors. We report 3 cases seen at our institution who were treated with a multimodality approach, all three remaining alive without evidence of active disease at 6 years, 2.25 years and 8 months respectively from diagnosis. We also review results of multimodality management, emphasizing the poor outcome for stage III and IV tumors in spite of multi-agent chemotherapy. Alternative drugs, such as cisplatinum may have a role in management. Finally, we propose that prophylactic pulmonary irradiation may have a place in advanced stages of adult Wilms' tumor.
authors.affiliation: Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison.
authors.forename: M P
authors.initials: MP
authors.lastname: Mehta
authors.forename: P
authors.initials: P
authors.lastname: Langeland
authors.forename: K
authors.initials: K
authors.lastname: Bertelrud
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000628:therapy*; D008168:Lung / Q000528:radiation effects*; D008297:Male; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality / Q000628:therapy*