Lack of effect of GR43175 on peripheral arteries in man.
In a double-blind, placebo-controlled crossover study in eight male volunteers, toe-arm systolic gradients, measured with strain-gauge plethysmography, were measured for 4 h after 2 mg intravenous GR43175 or placebo. No changes were observed, indicating that GR43175 is without significant vasoconstrictor effect on peripheral arteries in man.
Nielsen
T H
TH
Department of Neurology, University Hospital, Gentofte, Denmark.
Tfelt-Hansen
P
P
D000328:Adult; D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010991:Plethysmography; D011897:Random Allocation; D013449:Sulfonamides / Q000494:pharmacology*; D018170:Sumatriptan; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D007211:Indoles; D013449:Sulfonamides; D014662:Vasoconstrictor Agents; D018170:Sumatriptan