title: Shedding of herpes simplex virus type 1 into saliva in patients with orofacial fracture.
abstract: Shedding of herpes simplex virus type 1 (HSV-1) into saliva was studied in 83 patients with orofacial fractures. Infectious virus was isolated from 14 of 83 patients (16.8%) with no detectable herpetic lesion during hospitalization. Of the 83 patients, 44 (53%) had HSV-1 specific antibody. Virus shedding into saliva was observed only in the patients with antibody to HSV-1; thus, the frequency of virus shedding patients among those with antibody was 31% (14 of 44 patients). The frequency was obviously higher than that of a healthy population. The period of HSV-1 shedding had a mean of 3.7 days with range of 1 to 8 days, which is also significantly longer than that of a healthy population. These results strongly suggest that both treatment and operation lead effectively to reactivation of latently infected HSV-1.
authors.affiliation: Department of Oral Surgery, Kurume University School of Medicine, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: M
authors.initials: M
authors.lastname: Futami
authors.forename: N
authors.initials: N
authors.lastname: Nakayoshi
authors.forename: C
authors.initials: C
authors.lastname: Sujaku
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005147:Facial Bones / Q000293:injuries*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000382:microbiology*; D012703:Serotyping; D018139:Simplexvirus / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D012887:Skull Fractures / Q000150:complications / Q000382:microbiology*; D010948:Viral Plaque Assay; D014775:Virus Activation
chemical_list: D000914:Antibodies, Viral