Inhibition of the zymosan-induced chemiluminescence of human phagocytes by adenosine, polyadenylic acid and agents influencing adenosine metabolism.
The zymosan-induced chemiluminescence of human phagocytes (neutrophil granulocytes) could be inhibited by adenosine, polyadenylic acid, dipyridamole (an agent blocking the cellular adenosine uptake) and coformycin (a highly potent inhibitor of enzyme adenosine deaminase). It is suggested that in estimating the antianginal and antithrombotic action of dipyridamole, its action on the phagocytes should be taken into account. The same consideration would be true for 2'-deoxycoformycin (a coformycin analogue) used as a potent anticancer and immunosuppressive drug.
Sipka
S
S
3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
Szentmiklósi
A J
AJ
Nagy
A
A
Taskov
V
V
Szegedi
G
G
D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology*; D003070:Coformycin / Q000494:pharmacology*; D004176:Dipyridamole / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D011061:Poly A / Q000494:pharmacology*; D011983:Receptors, Purinergic / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism; D015054:Zymosan / Q000037:antagonists & inhibitors*
D011983:Receptors, Purinergic; D003070:Coformycin; D013481:Superoxides; D011061:Poly A; D004176:Dipyridamole; D015054:Zymosan; D000241:Adenosine