Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome.
A renal cell carcinoma with an unbalanced t(X;3) in a patient with von Hippel-Lindau (VHL) syndrome has previously been reported. This rearrangement suggested loss of genetic material from the short arm of chromosome 3, which we are now able to confirm by restriction fragment length polymorphism analysis of tumor DNA using polymorphic probes derived from 3p. The VHL gene has recently been mapped to 3p, therefore loss of this region in this VHL-related renal cell carcinoma may have cogent significance for tumor development in this interesting cancer-predisposing syndrome.
Decker
H J
HJ
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Gemmill
R M
RM
Neumann
H P
HP
Walter
T A
TA
Sandberg
A A
AA
D000798:Angiomatosis / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000235:genetics*; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D015342:DNA Probes; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000235:genetics*
D015342:DNA Probes