[Chemosensitivity of MGc 80-3 human gastric adenocarcinoma cells and its clinical significance].
The survival curves of MGc80-3 cells exposed for 24 hr to various concentrations of 10 anticancer drugs were obtained by means of colony-forming assay. Comparison of drug doses required to reduce cell survival by 90% (ID90) with the clinically achievable peak plasma drug concentration (PPC) showed that MMC, ADM, and 5-Fu had strong cytotoxicity (PPC/ID90 = 18-36), whilst the other drugs were less effective (PPC/ID90 less than or equal to 11). The fact that MMC, ADM, and 5-Fu are most effective in the treatment of gastric cancer suggests that the cell line MGc 80-3 may still retain its original drug sensitivity which is consistent with that noted in clinical gastric cancer. This cell line could be useful in screening for new compounds with activity against this disease.
Li
X T
XT
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000560:Amdinocillin / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil; D000560:Amdinocillin