[Comparative pathomorphologic study of the toxic properties of a corpuscular pertussis vaccine and of a cell-free pertussis preparation].
The comparative study of morphological changes in the body of outbred mice under the action of corpuscular pertussis vaccine and acellular pertussis preparation has been made. The corpuscular vaccine has been shown to produce a pronounced, dynamically increasing toxic effect, thus causing the damage of lymphoid thymic and spleen cells, prolonged interstitial reaction in the lungs, destructive inflammatory process at the site of injection. The acellular pertussis preparation is less toxic, induces less pronounced changes in these organs at the early period of the experiment, stimulates the proliferation of lymphoid cells and lymphoblast transformation. As noted in this study, the damaging action of pertussis vaccine is mainly indicated by pathological phenomena appearing in the organs of the immune system, pulmonary parenchyma and muscular tissue (in the inoculation zone).
Grigor'eva
L V
LV
Ozeretskovskaia
M N
MN
Chigirinskiĭ
A E
AE
Koval'skaia
S Ia
SIa
Bazhanova
I G
IG
D000818:Animals; D001685:Biological Factors / Q000276:immunology / Q000633:toxicity*; D001886:Bordetella pertussis / Q000276:immunology / Q000472:pathogenicity*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000633:toxicity*; D013997:Time Factors; D014917:Whooping Cough / Q000276:immunology / Q000473:pathology / Q000517:prevention & control
D001685:Biological Factors; D010567:Pertussis Vaccine
Sravnitel'noe patomorfologicheskoe izuchenie toksicheskikh svoĭstv korpuskuliarnoĭ kokliushnoĭ vaktsiny i beskletochnogo kokliushnogo preparata.