Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20.
We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA) gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNA gene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter in equilibrium Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12 in equilibrium 6pter and probably represents a second pseudogene.
Ku
D H
DH
Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Travali
S
S
Calabretta
B
B
Huebner
K
K
Baserga
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D007438:Introns; D008969:Molecular Sequence Data; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*; D018809:Proliferating Cell Nuclear Antigen; D011544:Pseudogenes; D014960:X Chromosome
D015342:DNA Probes; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D004247:DNA