A role of carbohydrate-carbohydrate interaction in the process of specific cell recognition during embryogenesis and organogenesis: a preliminary note.
A possible role of cell surface glycoconjugates in cell recognition has been envisioned based on recognition of carbohydrates by cell surface proteins such as endogenous lectins, glycosyltransferases, and hydrolases (refs. 18-22 in text). A new possibility that a specific carbohydrate at the cell surface could be recognized by the same or similar carbohydrate on the counterpart cell surface is now suggested by specific interaction between Lex and Lex, but not between Lex and sialylated or non-substituted type 2 chain. A new hypothesis is hereby proposed for carbohydrate-carbohydrate interactions as recognition signals during embryogenesis and organogenesis.
Eggens
I
I
Biomembrane Institute, Seattle, WA 98119.
Fenderson
B A
BA
Toyokuni
T
T
Hakomori
S
S
D000954:Antigens, Surface; D002118:Calcium / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D002449:Cell Aggregation / Q000187:drug effects; D005314:Embryonic and Fetal Development; D006017:Glycolipids / Q000378:metabolism*; D007785:Lactose / Q000494:pharmacology; D016256:Lewis X Antigen; D008081:Liposomes / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D013724:Teratoma; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface; D006017:Glycolipids; D016256:Lewis X Antigen; D008081:Liposomes; D011134:Polysaccharides; D008274:Magnesium; D007785:Lactose; D002118:Calcium