title: An Eco RI polymorphic site in the human complement C4 gene distinguishes juvenile rheumatoid arthritis (JRA) susceptibility-bearing haplotypes.
abstract: Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards.
authors.affiliation: Department of Immunology, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: J L
authors.initials: JL
authors.lastname: Vicario
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Laso
authors.forename: A
authors.initials: A
authors.lastname: Corell
authors.forename: J R
authors.initials: JR
authors.lastname: Regueiro
authors.forename: J
authors.initials: J
authors.lastname: Gomez-Reino
authors.forename: J
authors.initials: J
authors.lastname: Gomez-Reino
mesh_terms: D001171:Arthritis, Juvenile / Q000235:genetics*; D001665:Binding Sites; D002648:Child; D003181:Complement C4 / Q000235:genetics*; D004198:Disease Susceptibility; D005796:Genes; D006684:HLA-DR Antigens; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D003181:Complement C4; D006684:HLA-DR Antigens