Leucocyte common antigen in the differential diagnosis of Hodgkin's disease.
The utility of immunohistochemical staining for leukocyte common antigen (LCA) in the differential diagnosis of Hodgkin's disease was studied in a series of 42 cases of Hodgkin's and non-Hodgkin's lymphoma and compared with Leu M-1, a proposed marker for Reed-Sternberg cells. LCA staining of neoplastic cells was absent in 23 of 24 cases of Hodgkin's disease but present in 16 of 18 cases of non-Hodgkin's lymphoma including eight of 10 cases with pleomorphic Reed-Sternberg-like cells. Leu M-1, in contrast was present in 14 of 24 cases of Hodgkin's disease, but also in five of 18 cases of non-Hodgkin's lymphoma including five of 10 cases with pleomorphic Reed-Sternberg-like cells. Immunohistochemical staining for LCA appears useful in the differential diagnosis of Hodgkin's disease and appears to be a better discriminant than Leu M-1.
Strauchen
J A
JA
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029.
D000943:Antigens, Differentiation / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D003937:Diagnosis, Differential; D006649:Histocompatibility Antigens / Q000032:analysis*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens; D016256:Lewis X Antigen
D000943:Antigens, Differentiation; D015214:Antigens, Differentiation, Myelomonocytic; D006649:Histocompatibility Antigens; D016256:Lewis X Antigen; D017493:Leukocyte Common Antigens