title: [Regulation of the postsynaptic alpha-1-adrenoreceptors of the smooth muscle of the nictitating membrane in the cat].
abstract: Radioassay binding of the smooth muscle of the nictitating membrane of cat has revealed the specific binding sites of [3H]prazosin corresponding to alpha-1 adrenoceptors. There was a significant increase in the number of alpha-1 adrenoceptors without any changes in their affinity. Incubation of the culture of the preliminary sympathectomized smooth muscle with noradrenaline decreased the number of alpha-1 adrenoceptors also without altering the affinity of binding. So, it is concluded that sympathetic nervous system regulated the number of postsynaptic alpha-1 adrenoceptors by means of neurotransmitter (noradrenaline).
authors.forename: E N
authors.initials: EN
authors.lastname: Telina
authors.forename: S V
authors.initials: SV
authors.lastname: Kirshin
authors.forename: R S
authors.initials: RS
authors.lastname: Nizamov
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Akhmedzianov
authors.forename: Kh S
authors.initials: KhS
authors.lastname: Khamitov
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009541:Nictitating Membrane / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D011224:Prazosin / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D013562:Sympathectomy; D014316:Tritium
chemical_list: D011942:Receptors, Adrenergic, alpha; D014316:Tritium; D009638:Norepinephrine; D011224:Prazosin
vernacular_title: Reguliatsiia postsinapticheskikh al'fa-1-adrenoretseptorov gladkoĭ myshtsy migatel'noĭ pereponki koshki.