Interactions between the metabolism of n-3 and n-6 fatty acids.
Dietary n-3 fatty acids modify the fatty acid composition of phospholipids of different cells and tissues from rats in diverse ways. Neutrophil and platelet phospholipids contain elevated amounts of 20:5n-3, but only relatively small changes occur in the levels of 22-carbon n-3 fatty acids. Conversely, dietary n-3 acids result primarily in an increase in 22-carbon n-3 acids in heart, liver and kidney phospholipids. Platelets metabolize exogenous n-6 and n-3 fatty acids into a variety of different autocoids. However, it appears that only arachidonate and 20:5n-3 are released from phospholipids upon agonist-induced stimulation of phospholipases. Neutrophils metabolize arachidonate and 20:5n-3 in similar ways, both relative to phospholipid biosynthesis and the subsequent release of these acids for metabolism into leukotrienes.
Sprecher
H
H
Department of Physiological Chemistry, Ohio State University, Columbus.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D003314:Corn Oil / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D005395:Fish Oils / Q000378:metabolism; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism; D051381:Rats; D017962:alpha-Linolenic Acid
D004041:Dietary Fats; D005395:Fish Oils; D008041:Linoleic Acids; D008042:Linolenic Acids; D008563:Membrane Lipids; D017962:alpha-Linolenic Acid; D003314:Corn Oil