Imaging benzodiazepine receptors in the human brain by single photon emission computed tomography (SPECT).
Recently, [123I]Ro16-0154 has been introduced as a potential benzodiazepine (BZD) receptor imaging tracer for SPECT. We investigated the biodistribution of [123I]Ro16-0154 in humans and compared it with the animal data. There was a rapid and high 123I-uptake in the brain comparable to rCBF. In the following images, however, regionally different changes were observed, resulting in a subsequent intracerebral retention parallel to the known distribution of BZD receptors. The results suggest that [123I]Ro16-0154 is of potential clinical use as a BZD receptor imaging agent.
Höll
K
K
Department of Neuronuclear Medicine and Neurophysiology, Wagner-Jauregg Hospital, Linz, Switzerland.
Deisenhammer
E
E
Dauth
J
J
Carmann
H
H
Schubiger
P A
PA
D000328:Adult; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D005442:Flumazenil / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000032:analysis*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil