[Changes in the characteristics of the lymphocyte beta 2-adrenoreceptors under the influence of prostaglandin E2 infusions in hypertension patients].
Lymphocyte beta 2-adrenoreceptor density and affinity for catecholamines (CA) were examined in 22 patients with essential hypertension (EH) which was resistant to therapy. Lymphocyte beta 2-adrenoreceptor density was 1.5 times more in EH patients than in normotensive donors, but the receptor affinity for CA was the same. Prostaglandin E2 infusions permitted the resistance to antihypertensive therapy be overcome in 17 patients; it was accompanied by a decrease in of lymphocyte beta 2-adrenoreceptor density, receptor's affinity for 1-isoproterenol showed a 7-fold increase. There was no steady antihypertensive effect on prostaglandin E2 infusions in 5 EH patients: in these cases lymphocyte beta 2-adrenoreceptor density increased and their affinity for CA decreased.
Minchuna
V P
VP
Krasnikova
T L
TL
Runikhin
A Iu
AIu
Svet
E A
EA
Stareev
V E
VE
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015232:Dinoprostone / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008214:Lymphocytes / Q000032:analysis / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000187:drug effects*; D014680:Veins
D000959:Antihypertensive Agents; D011943:Receptors, Adrenergic, beta; D015232:Dinoprostone
Izmenenie pod vliianiem infuziĭ prostaglandina E2 kharakteristik beta 2-adrenoretseptorov limfotsitov u bol'nykh gipertonicheskoĭ bolezn'iu.