title: [Therapeutic study of the effect of selective decontamination on microbial overgrowth syndrome of the small intestine].
abstract: The microbial overgrowth syndrome of the small bowel (MOS) is characterized by clinically found symptoms of increased metabolic activities of microorganisms existing in a great number in the intestinal juice of these patients. We treated 15 patients who suffered from MOS following a modified scheme of selective intestinal decontamination (SID) with oral doses of BerlocombinR (trimethoprim/sulfamerazin) and polymyxin for three weeks. Comparative investigations of duodenal juices before and after treatment showed unchanged high germ-counts (total aerobes and total anaerobes up to 10(7) germs/ml juice). Only the increase of Clostridium (up to 10(6)/ml) was statistically significant which has to be disapproved. In most of the patients there was no subjective improvement. SID in the examined manner is not able to cure a microbial overgrowth in the upper gastrointestinal tract or to reduce facultatively pathogenic microorganisms.
authors.affiliation: Klinik für Innere Medizin, Bereichs Medizin der Ernst-Moritz-Arndt-Universität Greifswald, DDR.
authors.forename: M
authors.initials: M
authors.lastname: Knoke
authors.forename: H
authors.initials: H
authors.lastname: Bernhardt
authors.forename: R
authors.initials: R
authors.lastname: Möllmann
authors.forename: T
authors.initials: T
authors.lastname: Bootz
mesh_terms: D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D004338:Drug Combinations / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004386:Duodenum / Q000382:microbiology; D004751:Enteritis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011113:Polymyxins / Q000627:therapeutic use*; D013416:Sulfamerazine / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D004338:Drug Combinations; D011113:Polymyxins; D013416:Sulfamerazine; D014295:Trimethoprim; C014230:trimerazine; D000096926:Benzenesulfonamides
vernacular_title: Therapeutische Studie zum Einfluss der selektiven Dekontamination auf das mikrobielle Overgrowth-Syndrom des Dünndarms.