Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome.
The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.
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Whitehead Institute, Nine Cambridge Center, MA 02142.
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D000818:Animals; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012732:Sex Determination Analysis; D014998:Y Chromosome