Wilms' tumour and related syndromes. A unifying theory.
The major role of somatic crossing-over in the aetiology of Wilms' tumour and other forms of cancer is emphasized. A model is proposed to show that tumour development is due to a cis-trans disruptive effect of somatic crossing-over on the maintenance of differential parental imprinting.
Côté
G B
GB
Genetics Division, Institute of Child Health, Athens, Greece.
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003434:Crossing Over, Genetic; D005134:Eye Neoplasms / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008954:Models, Biological; D012175:Retinoblastoma / Q000235:genetics*; D013577:Syndrome; D009396:Wilms Tumor / Q000235:genetics*