[Effect of salazosulfapyridine (sulfasalazine) on the function of the complement system in rats with adjuvant arthritis].
In experiments on 24 albino male rats weighing 150-200 g it was found that the complement system and autoimmune humoral reactions are involved in the development of adjuvant arthritis. The use of sulfasalazine since the 10th day after intragastric administration of Freund complete adjuvant in a daily dose of 250 mg/kg for 2 weeks increased the activity of the complement system and decreased the autoimmune component. The data obtained clarify one of the possible mechanisms of allergic reactions to sulfasalazine which is related to the complement system activation.
Baranovskiĭ
P V
PV
Vysitskiĭ
I Iu
IIu
Boliukh
M Z
MZ
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D003167:Complement Activation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D012460:Sulfasalazine / Q000627:therapeutic use*; D013997:Time Factors
D000936:Antigen-Antibody Complex; D012460:Sulfasalazine
Vliianie salazosul'fapiridna (sul'fasalazaina) na sostoianie sistemy komplementa u krys s ad"iuvantnym artritom.