title: Detection and identification of the plant lignans lariciresinol, isolariciresinol and secoisolariciresinol in human urine.
abstract: The mammalian lignans enterolactone and enterodiol are regular constituents of human urine and are excreted daily in mumol amounts. They are produced by metabolic action of intestinal bacteria from natural plant lignan precursors which are constituents of various food plants. However, natural plant lignans seem to occur very seldom in detectable amounts in human urine. The present investigation shows that only in 5% of the 150 diphenolic fractions extracted from the urine of women plant lignans other than the previously identified matairesinol could be found. The lignans lariciresinol, isolariciresinol and secoisolariciresinol were identified for the first time by comparison of their GC characteristics and mass spectra with the corresponding results of authentic synthesized reference compounds. Secoisolariciresinol is one natural precursor of the mammalian lignan enterodiol. Of the two other plant lignans, no animal or human metabolic products are known. The occurrence of chemically unchanged plant lignans in some cases in human urine could be a result of an insufficient metabolic capacity of intestinal bacteria, resulting in a decreased detoxification of phenolic plant products.
authors.affiliation: Department of Clinical Chemistry, University of Helsinki, Finland.
authors.forename: C
authors.initials: C
authors.lastname: Bannwart
authors.forename: H
authors.initials: H
authors.lastname: Adlercreutz
authors.forename: K
authors.initials: K
authors.lastname: Wähälä
authors.forename: G
authors.initials: G
authors.lastname: Brunow
authors.forename: T
authors.initials: T
authors.lastname: Hase
mesh_terms: D000328:Adult; D002072:Butylene Glycols / Q000652:urine*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005663:Furans / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D017705:Lignans; D008031:Lignin / Q000652:urine*; D009284:Naphthols / Q000652:urine; D010936:Plant Extracts / Q000652:urine*
chemical_list: D002072:Butylene Glycols; D005663:Furans; D017705:Lignans; D009284:Naphthols; D010936:Plant Extracts; C060284:isolariciresinol; C060282:lariciresinol; D008031:Lignin; C060283:secoisolariciresinol