title: Effect of breast-feeding on immune response to BCG vaccination.
abstract: The effect on BCG immunisation of feeding either formula or breast milk was assessed in Canadian Cree infants who were vaccinated either at birth or after 1 month of age. The response to BCG was measured in terms of lymphocyte blastogenesis stimulated by purified protein derivative of Mycobacterium tuberculosis. Breast-feeding significantly enhanced cell-mediated immune response to BCG vaccine given at birth, but had no significant effect if vaccine was given after 1 month. These findings were not related to maternal history of tuberculosis or BCG vaccination, and the feeding method did not influence lymphocyte stimulation by candida or streptococcal antigens.
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Canada.
authors.forename: H F
authors.initials: HF
authors.lastname: Pabst
authors.forename: J
authors.initials: J
authors.lastname: Godel
authors.forename: M
authors.initials: M
authors.lastname: Grace
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: D W
authors.initials: DW
authors.lastname: Spady
mesh_terms: D000367:Age Factors; D000416:Alberta; D001500:BCG Vaccine / Q000276:immunology*; D001942:Breast Feeding; D002175:Candida / Q000276:immunology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007198:Indians, North American; D007225:Infant Food; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013300:Streptokinase / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D001500:BCG Vaccine; D013300:Streptokinase