Short time action of antirheumatic substances on the liver of rat. Protective effect of tryptophan + methionine.
1. A large number of drugs, including some antirheumatic substances, cause liver damage. 2. Only a little information is available, so far, on the causes of such damage and their prevention. 3. From studies on a number of antirheumatic drugs as to their effect upon the liver, three categories could be differentiated: (a) large effect (b) low effect (c) no effect. 4. Judging from our results, the liver damage is induced via a disturbance of the NAD-adenoribosylation metabolism.
Kröger
H
H
Robert Koch-Institut, Berlin, F.R.G.
Sohst
S
S
Grätz
R
R
Dietrich
A
A
Grahn
H
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008715:Methionine / Q000494:pharmacology*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000494:pharmacology*; D014444:Tyrosine Transaminase / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014364:Tryptophan; D008715:Methionine; D011065:Poly(ADP-ribose) Polymerases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014444:Tyrosine Transaminase