Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity.
Handley
D A
DA
Platelet Biology and Chemistry, Sandoz Research Institute, East Hanover, New Jersey 07936.
Houlihan
W J
WJ
Tomesch
J C
JC
Farley
C
C
Deacon
R W
RW
Koletar
J M
JM
Prashad
M
M
Hughes
J W
JW
Jaeggi
C
C
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins; D011806:Quinolinium Compounds / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects; D043562:Receptors, G-Protein-Coupled; D013329:Structure-Activity Relationship
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011806:Quinolinium Compounds; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; C050531:SRI 63-441