Cytomegalovirus retinitis treated with ganciclovir in a renal transplant recipient.
Cytomegalovirus retinitis is an opportunistic and vision-threatening disease in immunosuppressed patients. Currently available antiviral agents have been unsuccessful in halting its progression. We report a case of cytomegalovirus retinitis which occurred 6 months after renal transplantation and was successfully treated with an investigational drug, ganciclovir (DHPG [Dihydroxy propoxymethyl guanine], Cytovene, BW-B759U), via intravenous administration, with resolution of active retinal lesions and the cessation of cytomegalovirus shedding in the urine. There was neither a recurrence of cytomegalovirus retinitis nor an occurrence of retinal detachment during the 9-month follow-up after intravenous ganciclovir therapy.
Horng
I H
IH
Chen
M S
MS
Lee
P H
PH
Chen
Y C
YC
Lee
C S
CS
Hou
P K
PK
D000328:Adult; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D012173:Retinitis / Q000188:drug therapy*
D015774:Ganciclovir