Effects of two inotropic drugs, dopamine and dobutamine, on pulmonary gas exchange in artificially ventilated patients.
The inotropic agents, dopamine (DP) and dobutamine (DB), both decrease PaO2, probably by a redistribution of the VA/Q ratio. The aim of this study was to assess the effect of both drugs on the VA/Q ratio, using the multiple inert gas elimination method. Ten artificially ventilated patients (eight males), aged 45-74 years were investigated. Blood gases, cardiac output and concentrations of inert gases were measured before and 30 min after infusion of DB or DP. DP and DB were administered alternatively at a rate of 5 micrograms.k-1 min-1. The decrease in PaO2 was significantly greater with DP (12 +/- 9 torr) than with DB (7 +/- 9 torr) (P less than 0.01). Both drugs similarly increased cardiac output: +2.61.min-1 +/- 1.4 for DP and 2.21.min-1 +/- 1.5 for DB. Both DP and DB significantly (P less than 0.01) increased the perfusion of alveoli with VA/Q = 0 (+4 +/- 7% for DP and +3 +/- 7% for DB) and 0 less than VA/Q less than 0.1 (+11 +/- 8.5% for DP and +5.5 +/- 10.5% for DB) (no significant difference between the drugs). When shunt and "shunt-like" effect are considered together, there was a significantly greater increase in the amount of blood going to alveoli with a low VA/Q ratio with DP compared to DB. Both drugs decreased the perfusion of alveoli with 0.1 less than VA/Q less than 10, but the decrease was significantly less for DB than for DP (-15 +/- 6.5% for DP and -8.5 +/- 7% for DB, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Rennotte
M T
MT
Anesthesiology Department, Clinique Saint-Luc (U.C.L.), Brussels, Belgium.
Reynaert
M
M
Clerbaux
T
T
Willems
E
E
Roeseleer
J
J
Veriter
C
C
Rodenstein
D
D
Frans
A
A
D000368:Aged; D002302:Cardiac Output / Q000187:drug effects; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D005741:Noble Gases; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012121:Respiration, Artificial; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects
D005741:Noble Gases; D004280:Dobutamine; D004298:Dopamine