title: Acetylator phenotype and short-course chemotherapy for tuberculosis in Papua New Guinea.
abstract: In Papua New Guinea the slow acetylator phenotype is unusual and peripheral neuropathy during isoniazid therapy is uncommon. Acetylator status and other factors influencing isoniazid-induced peripheral neuropathy are discussed, and statistics from Papua New Guinea are presented. The relevance of acetylator phenotype to other side-effects of isoniazid is less well defined. Prophylactic pyridoxine supplementation during short-course chemotherapy for tuberculosis is not generally necessary in the daily 'A' regimen, but should be maintained in the twice-weekly (high-dose isoniazid) 'B' regimen for adults and children over 20 kg.
authors.forename: B
authors.initials: B
authors.lastname: Currie
authors.forename: V
authors.initials: V
authors.lastname: Krause
authors.forename: P
authors.initials: P
authors.lastname: Mondia
authors.forename: B
authors.initials: B
authors.lastname: Hudson
mesh_terms: D000107:Acetylation; D004334:Drug Administration Schedule; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D010219:Papua New Guinea; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010641:Phenotype; D011736:Pyridoxine / Q000627:therapeutic use; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D011736:Pyridoxine; D007538:Isoniazid