title: Resistance of Escherichia coli to nourseothricin (streptothricin): reduced penetrability of the cell wall as an additional, possibly unspecific mechanism.
abstract: The resistance of E. coli strains to the antibiotic nourseothricin is known to be caused by an acetyltransferase acetylating the beta-lysine chain of the antibiotic. In addition, most of the resistant strains exhibit reduced penetrability of the outer membrane, presumably caused by a reduced amount of available negative charges. This was shown using crystal violet, Congo red, or the hydrophobic antibiotic novobiocin as indicators.
authors.affiliation: Institute of Experimental Epidemiology, Wernigerode, DDR.
authors.forename: G
authors.initials: G
authors.lastname: Seltmann
mesh_terms: D000042:Absorption; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000378:metabolism; D004396:Coloring Agents / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005840:Gentian Violet / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology; D011190:Potassium Cyanide / Q000494:pharmacology; D013309:Streptothricins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004396:Coloring Agents; D009675:Novobiocin; D013309:Streptothricins; D005840:Gentian Violet; D011190:Potassium Cyanide