Immune recognition of influenza virus haemagglutinin.
Haemagglutinin glycoproteins are the components of influenza virus membranes against which infectivity-neutralizing antibodies are directed. Sequence analysis of natural and laboratory-selected variant haemagglutinins indicates the regions of the molecule recognized by antibodies and by helper T cells; the identity of these regions and the relations between them are discussed.
Skehel
J J
JJ
National Institute for Medical Research, Mill Hill, London, U.K.
Barnet
B C
BC
Burt
D S
DS
Daniels
R S
RS
Douglas
A R
AR
Graham
C M
CM
Hodgson
J
J
Knossow
M
M
Mills
K H
KH
Riska
P F
PF
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000937:Antigen-Antibody Reactions; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000276:immunology*; D008961:Models, Structural; D008969:Molecular Sequence Data; D009154:Mutation; D011487:Protein Conformation; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral