Gastrin and somatostatin levels in patients with gastric cancer.
Gastrin and somatostatin-like immunoreactivity (SLI) levels were studied by means of radioimmunoassay in peripheral venous blood of healthy volunteers and patients suffering from gastric adenocarcinoma or duodenal and gastric ulcers. Gastrin and SLI levels were also evaluated in patients in blood drawn from gastric veins during surgery. The elevations of gastrin and SLI levels were found in patients with gastric cancer as compared with healthy people and patients suffering from ulcers. The impairment of the negative feedback between gastrin and somatostatin secretions in patients with gastric cancer was suggested.
Pawlikowski
M
M
Department of Experimental Endocrinology, School of Medicine, Lodz, Poland.
Cieślak
D
D
Berner
J
J
Rybiński
K
K
Lewiński
A
A
Webb
S M
SM
D000230:Adenocarcinoma / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood*; D013276:Stomach Ulcer / Q000097:blood
D005755:Gastrins; D013004:Somatostatin