DNA analysis of HLA-DR and DQ genes in American blacks with systemic lupus erythematosus.
We studied DNA polymorphisms of HLA-DR and DQ alleles in 63 American black patients with systemic lupus erythematosus (SLE). We found no HLA-DR beta, DQ alpha, or DQ beta restriction fragment length polymorphism (RFLP) or RFLP-determined DR or DQ specificity associated with SLE in either the patients or in 57 control subjects. DRw52b was positively associated with renal involvement and negatively associated with anti-nuclear RNP antibodies. Antibodies to Ro (SS-A) and La (SS-B) were associated with DR3(DRw17), DQw2.3. Early-onset SLE (less than or equal to 20 years of age) was associated with DRw8, and the frequency of neuropsychiatric involvement correlated negatively with a 3.7-kb Taq I DQ alpha RFLP. This suggests a role for DR and DQ genes in the clinical and serologic expression of SLE in American blacks.
Reveille
J D
JD
Department of Internal Medicine, University of Texas Health Science Center, Houston.
Schrohenloher
R E
RE
Acton
R T
RT
Barger
B O
BO
D044383:Black People / Q000235:genetics*; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008285:Major Histocompatibility Complex; D012150:Polymorphism, Restriction Fragment Length; D014481:United States; D001741:Black or African American
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens