Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption.
The potential clinical interest of a new isoform of alanine aminopeptidase (AAP) was examined using polyacrylamide gradient gel electrophoresis. This form, called F-AAP, is more proteolyzed than normal serum AAP. It appears to be associated with many liver diseases and is related to cytolysis, but also to elevated GGT levels. The F-AAP form was present in 52% of subjects treated with anticonvulsant drugs and in 64% of subjects consuming more than 44 g of alcohol per day. Analysis of F-AAP may be of interest in detecting effects of drugs and alcohol on the liver.
Sanderink
G J
GJ
Laboratoire du Centre de Médecine Préventive, UA CNRS no. 597, Vandoeuvre-les-Nancy, France.
Artur
Y
Y
Paille
F
F
Siest
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D000626:Aminopeptidases / Q000097:blood*; D018826:CD13 Antigens; D004796:Clinical Enzyme Tests; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008099:Liver / Q000187:drug effects; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010600:Pharmacology; D005723:gamma-Glutamyltransferase / Q000097:blood
D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D000626:Aminopeptidases; D018826:CD13 Antigens