Specific immunoglobulin response in mice immunized with porins and challenged with Salmonella typhi.
Specific antiporin antibody (IgG, IgM, and IgA) response was studied in control, infected, immunized-infected, and immunized mice. The activity of specific IgG immunoglobulins was found to be the highest in immunized and immunized-infected groups in which 87.5% protection had been observed by laboratory potency test in mice; the next-highest activities were those of IgM and IgA immunoglobulins. However, in the infected group the activity of specific IgM and IgG immunoglobulins was almost similar.
Sharma
P
P
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Sharma
B K
BK
Sharma
S
S
Sehgal
R
R
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis*; D000918:Antibody Specificity; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D007114:Immunization; D007136:Immunoglobulins / Q000096:biosynthesis*; D051379:Mice; D018272:Porins; D012485:Salmonella typhi / Q000276:immunology*
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D007136:Immunoglobulins; D018272:Porins