[Human herpesvirus 6 (HHV-6): incidence in healthy blood donors and in patients with acute infections caused by other herpes viruses].
Antibodies to HHV-6 were detected by immunofluorescence in 8.04% of 460 healthy blood donors in West Austria. Testing sera from patients with acute or reactivated infections with other herpesviruses, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV) and varicella zoster virus (VZV) we observed a remarkably higher prevalence of antibodies to HHV-6 in patients with CMV infections (75%) and also in patients with EBV infections (50%). Patients with HSV and VZV infections were positive for HHV 6 in 12.5% and 6.6% of cases, respectively. Many of the patients with CMV infection were transplant recipients. The high incidence of positive HH 6 serology in these patients could be due to new infection by HHV 6 or to the reactivation of a previous infection with HHV 6 by means of allogenic cell stimulation. Furthermore, preliminary results from our laboratory point to a serological cross-reaction between HHV 6 and CMV, which may also contribute to this result.
Larcher
C
C
Institut für Hygiene, Universität Innsbruck.
Huemer
H P
HP
Hönlinger
M
M
Margreiter
R
R
Dierich
M P
MP
D000914:Antibodies, Viral / Q000032:analysis*; D001782:Blood Donors; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000635:transmission; D006561:Herpes Simplex / Q000276:immunology / Q000635:transmission*; D006562:Herpes Zoster / Q000635:transmission; D006566:Herpesviridae Infections / Q000276:immunology / Q000635:transmission*; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral
Humanes Herpesvirus 6 (HHV-6): Vorkommen bei gesunden Blutspendern und in Patienten mit akuten Infektionen durch andere Herpesviren.