title: [Malignant mixed Müllerian tumors of the uterus. Clinical, morphologic and immunohistochemical findings].
abstract: Clinical and morphological findings in four patients with mixed mullerian tumors of the uterus showed, that these highly aggressive neoplasms are derived from the undifferentiated mullerian epithelium. Immunohistochemically, each component exhibits characteristic differentiation markers. The presence of cytokeratins or desmin signals an epithelial viz. rhabdomyosarcomatous differentiation, whilst the detection of vimentin in the absence of other markers demonstrates an undifferentiated mesenchymal component. This component appears to be responsible for the aggressive biological behavior of mixed mullerian tumors.
authors.affiliation: Senckenbergisches Zentrum der Pathologie, Universität Frankfurt.
authors.forename: S
authors.initials: S
authors.lastname: Falk
authors.forename: I
authors.initials: I
authors.lastname: Papaikonomou
authors.forename: H
authors.initials: H
authors.lastname: Böckler
authors.forename: H J
authors.initials: HJ
authors.lastname: Stutte
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014594:Uterine Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014599:Uterus / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Maligne Müllersche Mischtumoren des Uterus. Klinische, morphologische und immunhistochemische Befunde.