Multiple voltage-sensitive K+ channels regulate dendritic excitability in cerebellar Purkinje neurons.
Ionic conductances present in the dendritic region of the cerebellar Purkinje neuron were studied using the single-channel and whole-cell recording methods. Several types of voltage-sensitive K+ channels including a Ca2+ activated K+ channel were found to be a prominent components of the dendritic membrane. All patches studied contained K+ channel types and most patches contained more than one K+ channel type. In cell attached recordings, K+ channel activity was associated with the late phase of spontaneous action potentials suggesting a functional relationship. These data demonstrate that voltage-sensitive ion channels contribute to dendritic excitability and suggest that the transduction and integration of synaptic signals may involve both active and passive ionic conductances.
Gruol
D L
DL
Division of Preclinical Neuroscience and Endocrinology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Dionne
V E
VE
Yool
A J
AJ
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003712:Dendrites / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004558:Electric Stimulation; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011689:Purkinje Cells / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D015221:Potassium Channels; D009638:Norepinephrine