title: The availability of diltiazem: a study on the sorption by intravenous delivery systems and on the stability of the drug.
abstract: The stability and the sorption by intravenous delivery systems of the calcium antagonist diltiazem dissolved into either 5% dextrose or 0.9% sodium chloride solutions have been investigated, under conditions simulating current clinical practice. Static experiments showed an excellent stability and no sorption after 48 h. Dynamic experiments, at a perfusion rate of 20 mg h-1, showed no sorption of the drug by infusion fluid containers, burettes or administration sets. For end-line filters a temporary decrease of the recovered amount of diltiazem was observed but only with the 0.9% NaCl solution. It is concluded that the stability and the sorption of diltiazem offers no problem with regard to clinical efficacy.
authors.affiliation: Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: De Vroe
authors.forename: C
authors.initials: C
authors.lastname: De Muynck
authors.forename: J P
authors.initials: JP
authors.lastname: Remon
authors.forename: R
authors.initials: R
authors.lastname: Scheldewaert
authors.forename: F
authors.initials: F
authors.lastname: Colardyn
mesh_terms: D000327:Adsorption; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004355:Drug Stability; D005374:Filtration; D007262:Infusions, Intravenous; D013997:Time Factors
chemical_list: D004110:Diltiazem