title: Peripheral neuropathy, coagulopathy and nodular regenerative hyperplasia of the liver in a patient with multiple serologic auto-antibody activities and IgM B-cell lymphoma.
abstract: A patient with IgM-secreting B-cell lymphoma developed demyelinating peripheral neuropathy, nodular regenerative hyperplasia of the liver, coagulopathy, and terminal miliary lymphomatous spreading. Serologic auto-antibody activities directed against myelin associated glycoprotein, prothrombinase complex (i.e. lupus anticoagulant) and smooth muscle cells were detected. It is suggested that there is a link between the IgM gammopathy, the immunological abnormalities and the various clinico-pathological conditions.
authors.affiliation: Service de Neurologie, Hôpital Henri Mondor, Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Zuber
authors.forename: R
authors.initials: R
authors.lastname: Gherardi
authors.forename: G
authors.initials: G
authors.lastname: Defer
authors.forename: P
authors.initials: P
authors.lastname: Gaulard
authors.forename: M
authors.initials: M
authors.lastname: Divine
authors.forename: E S
authors.initials: ES
authors.lastname: Zafrani
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001402:B-Lymphocytes / Q000032:analysis*; D001778:Blood Coagulation Disorders / Q000276:immunology*; D006801:Humans; D006965:Hyperplasia; D007075:Immunoglobulin M / Q000032:analysis*; D008099:Liver / Q000276:immunology / Q000473:pathology*; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology; D009186:Myelin Sheath / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M