title: Initial characterization of lens beta-adrenergic receptors.
abstract: Crude plasma membranes were prepared from chick lens epithelial and fiber cells and assayed for specific binding of the beta-adrenergic antagonist dihydroalprenolol. Both membranes specifically bound the ligand, with the epithelial membranes exhibiting a greater number of higher affinity sites. This is the first demonstration of lens beta-adrenergic receptors using this type of assay and the first direct demonstration of beta-adrenergic receptors in lens fiber cells.
authors.affiliation: Department of Anatomy/Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan.
authors.forename: M E
authors.initials: ME
authors.lastname: Ireland
authors.forename: L A
authors.initials: LA
authors.lastname: Jacks
mesh_terms: D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D004082:Dihydroalprenolol / Q000037:antagonists & inhibitors / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism* / Q000648:ultrastructure; D009994:Osmolar Concentration; D011433:Propranolol / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D011433:Propranolol