[Acute lymphoblastic Ph1-positive leukemia with a hybrid phenotype. The significance of the Ph1 anomaly and the hybrid phenotype].
The present paper reports on a case of acute lymphoblastic leukemia with t(9q+; 22q-) and surface markers specific of the B and T lymphoid line (hybrid phenotype). The fundamental (genotypical and phenotypical) and practical aspects (nosologic and therapeutical aspects) of this particular subtype of Ph1-positive acute leukemia and hybrid phenotype are discussed.
Nicoară
S
S
Stefănescu
D
D
Roman
S
S
Tudor
F
F
Butoianu
E
E
Ursea
C
C
Petrescu
A
A
Berceanu
S
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002869:Chromosome Aberrations; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005838:Genotype; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D010641:Phenotype; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics
Leucemia acută limfoblastică Ph1 pozitivă cu fenotip hibrid. Semnificaţia anomalie Ph1 şi a fenotipului hibrid.