Cyclic Cushing's disease in association with a pituitary stone.
We have documented what we believe to be the first reported case of a pituitary stone in a patient with pituitary-dependent Cushing's disease. Pituitary stones have been reported exclusively in growth-hormone-producing or prolactin-producing pituitary adenomas. Our patient's ACTH and serum cortisol levels cycled for 15 months and then resolved spontaneously. A CT scan of the head showed calcification of pituitary tissue. Pituitary stones may occur in association with Cushing's disease. We hypothesize that the spontaneous resolution of the cyclic Cushing's disease was due to destruction and ultimate calcification of abnormal pituitary tissue.
La Civita
K A
KA
Department of Medicine, USAF Medical Center, Wright-Patterson AFB, Ohio.
McDonald
S
S
Jacobson
J
J
D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000652:urine; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002114:Calcinosis / Q000097:blood / Q000150:complications* / Q000652:urine; D002940:Circadian Rhythm; D003480:Cushing Syndrome / Q000097:blood / Q000150:complications* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications* / Q000652:urine; D011388:Prolactin / Q000097:blood; D012658:Sella Turcica; D013997:Time Factors
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006854:Hydrocortisone