Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone.
The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1-29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.
Delitala
G
G
Istituto di Endocrinologia e di Ematologia, Università di Sassari, Italy.
Tomasi
P A
PA
Palermo
M
M
Ross
R J
RJ
Grossman
A
A
Besser
G M
GM
D000328:Adult; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone