Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum.
The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (greater than 100%) and bisphosphate (greater than 20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.
Rubinstein
J E
JE
Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.
Hitzemann
R J
RJ
Ashby
C R
CR
Wang
R Y
RY
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*
D014150:Antipsychotic Agents; D010716:Phosphatidylinositols; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D011976:Receptors, Muscarinic; D002217:Carbachol