The noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits.
Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.
Scheller
M S
MS
Department of Anesthesiology, University of California San Diego, La Jolla 92093.
Zornow
M H
MH
Fleischer
J E
JE
Shearman
G T
GT
Greber
T F
TF
D000758:Anesthesia; D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000493:pharmacokinetics / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D004569:Electroencephalography; D006207:Half-Life; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects; D007530:Isoflurane; D011817:Rabbits; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate; D007530:Isoflurane; D006221:Halothane