Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.
High-dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.
Nevill
T J
TJ
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Benstead
T J
TJ
McCormick
C W
CW
Hayne
O A
OA
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D003630:Daunorubicin / Q000008:administration & dosage; D003711:Demyelinating Diseases / Q000139:chemically induced*; D006732:Horner Syndrome / Q000139:chemically induced*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D003561:Cytarabine; D003630:Daunorubicin