In vitro effect of lorazepam on Mg2+ and (Na+,K+) ATPases of human foetal brain.
Lorazepam (LZ), a benzodiazepine group of drug, inhibits Mg2+ and (Na+,K+) ATPases (EC 3.6.1.3) activity of human foetal and adult brain. The inhibitory effect neither varied with respect to the region (i.e. cerebrum and cerebellum) nor with the age of the foetus. The inhibition of ATPases activity indicates that the neuronal transmission processes, may be affected and raises the possibility of developmental disturbances.
Saha
U K
UK
Sengupta
T
T
Dutta
C
C
Sirkar
A
A
Sengupta
D
D
D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D005333:Fetus; D006801:Humans; D066298:In Vitro Techniques; D008140:Lorazepam / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D008140:Lorazepam