Coxsackie virus and rheumatic fever. A correlative study.
Twenty-one patients of whom 13 had acute rheumatic fever and 8 had recurrence of rheumatic fever were studied for the evidence of coxsackie B viral infection using neutralisation test. A significant rise was noted in 17 cases (81%) and two cases had very high initial titre of neutralising antibodies to coxsackie B viruses type 1 to 6. Mixed infection with more than one serotype was seen in 11 cases. Coxsackie B2 was the commonest type and 14 patients had antistreptolysin 'O' anti-bodies. The high incidence of coxsackie B viral infection in rheumatic fever and the coexistent streptococcal infection and their relationship are discussed.
Suresh
L
L
Chandrasekar
S
S
Rao
R S
RS
Ravi
V
V
Badrinath
S
S
D000293:Adolescent; D000328:Adult; D003384:Coxsackievirus Infections / Q000382:microbiology*; D003937:Diagnosis, Differential; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000382:microbiology*; D012214:Rheumatic Heart Disease / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification