Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice.
A series of classical, atypical and putative antipsychotic drugs were compared for their ability to inhibit isolation-induced intraspecies aggression with affinity for D-2 dopamine receptors and induction of akinesia. The majority of drugs tested significantly inhibited aggressive behavior only after doses that greatly decreased the ability of mice to move. Even though akinesia seemed to account for inhibition of aggression there was no apparent correlation with binding to striatal D-2 receptors.
McMillen
B A
BA
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858.
DaVanzo
E A
EA
Song
A H
AH
Scott
S M
SM
Rodriguez
M E
ME
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D018492:Dopamine Antagonists; D008297:Male; D051379:Mice; D009069:Movement Disorders / Q000139:chemically induced; D012934:Social Isolation
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists