An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man.
Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha 2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha 2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha 2 antagonist.
Palazidou
E
E
Institute of Psychiatry, London, UK.
Papadopoulos
A
A
Sitsen
A
A
Stahl
S
S
Checkley
S
S
D000317:Adrenergic alpha-Antagonists / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D008803:Mianserin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D000078785:Mirtazapine
D000317:Adrenergic alpha-Antagonists; D008803:Mianserin; D000078785:Mirtazapine; D008550:Melatonin