Platelet serotonin uptake and 3H-imipramine binding in panic disorder.
Platelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed.
Norman
T R
TR
Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia.
Sartor
D M
DM
Judd
F K
FK
Burrows
G D
GD
Gregory
M S
MS
McIntyre
I M
IM
D000328:Adult; D000379:Agoraphobia / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D010200:Panic / Q000502:physiology*; D010698:Phobic Disorders / Q000097:blood*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012701:Serotonin / Q000097:blood*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine