title: Persistent polyuria in two dogs following adrenocorticolysis for pituitary-dependent hyperadrenocorticism.
abstract: In two dogs with pituitary-dependent hyperadrenocorticism, adrenocorticolysis with o.p'-DDD led to the disappearance of the signs and symptoms except for the polyuria. After a modified water-deprivation test the osmoregulation of vasopressin release was studied by hypertonic saline infusion. In both dogs the hypertonicity, thus induced, resulted in very minimal responses of the vasopressin secretion.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Biewenga
authors.forename: A
authors.initials: A
authors.lastname: Rijnberk
authors.forename: J A
authors.initials: JA
authors.lastname: Mol
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000324:Adrenocorticotropic Hormone / Q000009:adverse effects; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000378:metabolism / Q000662:veterinary*; D012008:Recurrence; D014667:Vasopressins / Q000172:deficiency / Q000187:drug effects; D014868:Water Deprivation
chemical_list: D000305:Adrenal Cortex Hormones; D014667:Vasopressins; D000324:Adrenocorticotropic Hormone