Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency.
The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electroencephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed. The lethality in Group A made up 59% and that in Group B was 37%.
Margulis
M S
MS
Department of Experimental Surgery and Temporary Organ Substitution, Riga Medical Institute, Latvia, USSR.
Erukhimov
E A
EA
Andreiman
L A
LA
Viksna
L M
LM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care / Q000379:methods*; D004569:Electroencephalography; D006464:Hemoperfusion / Q000379:methods*; D006501:Hepatic Encephalopathy / Q000628:therapy*; D006801:Humans; D008099:Liver / Q000166:cytology*; D008875:Middle Aged