Effects of cyclophosphamide on pigs infected and vaccinated with swinepox virus.
Piglets treated with cyclophosphamide (50 mg/kg body wt, iv) before infection/vaccination with swinepox virus showed a strong suppression of humoral immune response. Cell mediated immune response was also affected to some extent and the cyclophosphamide treated piglets did not resist the challenge on 21 day post infection/vaccination and developed mild lesions.
Verma
P C
PC
Rai
A
A
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002464:Cell Migration Inhibition; D003520:Cyclophosphamide / Q000494:pharmacology*; D011212:Poxviridae / Q000276:immunology*; D011213:Poxviridae Infections / Q000276:immunology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*; D014611:Vaccination; D014765:Viral Vaccines
D000914:Antibodies, Viral; D014765:Viral Vaccines; D003520:Cyclophosphamide