[Parkinson's disease: some physiopathologic aspects and clinical practice].
The lesions of Parkinson's disease chiefly involve the dopaminergic nigrostriatal tract and the great subcortical-cortical dopaminergic, noradrenergic, serotoninergic and cholinergic neuron systems. On the basis of these data, one may suggest a mechanism for some motor and mental disorders, as well as the rationale for treatment with L-dopa, the origin of its main side-effects and the classical escape phenomenon observed with this drug.
Agid
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D003072:Cognition Disorders / Q000209:etiology; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents / Q000627:therapeutic use; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D009043:Motor Activity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D013378:Substantia Nigra
D015259:Dopamine Agents; D007980:Levodopa; D004298:Dopamine
Maladie de Parkinson: quelques aspects physiopathologiques et pratique clinique.