title: Presynaptic effects of spider toxins: increase of high affinity uptake in the arthropod peripheral glutamatergic system.
abstract: In contrast to the reported effects of polyamines on the high affinity neurotransmitter uptake, two polyamine-like spider toxins significantly increase the high affinity uptake of glutamate as demonstrated with high resolution autoradiography. The effects of both spider toxins were compared to those of a polyamine toxin from the wasp Philanthus triangulum, which is known to inhibit the high affinity glutamate uptake.
authors.affiliation: Department of Electron Microscopy, University of Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van Marle
authors.forename: T
authors.initials: T
authors.lastname: Piek
authors.forename: H
authors.initials: H
authors.lastname: Karst
authors.forename: A
authors.initials: A
authors.lastname: Lind
authors.forename: J
authors.initials: J
authors.lastname: van Weeren-Kramer
mesh_terms: D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D001345:Autoradiography; D001369:Axons / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006110:Grasshoppers / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000294:innervation; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D013111:Spider Venoms / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
chemical_list: D001180:Arthropod Venoms; D005971:Glutamates; D013111:Spider Venoms; D018698:Glutamic Acid