title: A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine.
abstract: A method is presented for the simultaneous identification and quantification of several CNS stimulants, including amphetamine in plasma and urine by GC/FID using mephentermine as an internal standard. No derivation is necessary and after a single alkaline extraction, GC analysis for the 11 compounds tested is achieved in 23 min. The lower limit of detectability was found to be 4 ng/ml for amphetamine in plasma. This method is sensitive, reproducible, selective and applicable in forensic and clinical toxicological analyses. Toxicological findings, after a fatality involving phendimetrazine are presented as an application of the procedure.
authors.affiliation: Institut de Médecine Légale, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Kintz
authors.forename: A
authors.initials: A
authors.lastname: Tracqui
authors.forename: P
authors.initials: P
authors.lastname: Mangin
authors.forename: A A
authors.initials: AA
authors.lastname: Lugnier
authors.forename: A J
authors.initials: AJ
authors.lastname: Chaumont
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000032:analysis; D000697:Central Nervous System Stimulants / Q000032:analysis*; D002849:Chromatography, Gas; D004300:Doping in Sports; D006801:Humans; D008297:Male; D009025:Morpholines / Q000032:analysis* / Q000506:poisoning
chemical_list: D000697:Central Nervous System Stimulants; D009025:Morpholines; C100294:phendimetrazine; D000661:Amphetamine