Multiple versus single antipsychotic drug treatment in chronic psychosis.
Fourteen patients receiving multiple antipsychotic drugs in a state mental hospital long-term unit comprised the study sample. They completed a 1-year clinical trial to reduce such drugs to a single antipsychotic agent. Six of the 14 patients were successfully converted to a single antipsychotic drug without clinical deterioration. Eight patients showed marked psychiatric decompensation when converted to single antipsychotic therapy. Factors that may have contributed to this difference are discussed.
Godleski
L S
LS
Western State Hospital, Department of Mental Health and Mental Retardation, Commonwealth of Virginia, Stauton 24401.
Kerler
R
R
Barber
J W
JW
Glick
J L
JL
Kellogg
E
E
Vieweg
W V
WV
Yank
G R
GR
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology
D014150:Antipsychotic Agents