Pattern of enzyme changes in rabbits administered linamarin or potassium cyanide.
Diseases like tropical ataxic neuropathy and endemic goitre have been reported to have definite correlation with a chronic ingestion of cassava (Manihot esculenta Crantz). The toxicity of cassava has been attributed to its two cyanogenic glycosides, linamarin and lotaustralin. In this study, an attempt has been made to understand the pattern of changes in certain clinically significant enzymes brought about by the chronic administration of sublethal doses of linamarin to rabbits. The profound elevation in rhodanese activity observed in the linamarin and cyanide treated rabbits indicated the attempt of the tissues to detoxify cyanide. That intact linamarin could be hydrolysed in vivo was a significant finding from the study. The mode of toxicity of linamarin was similar to that of cyanide by producing a gradual shift from aerobic to anaerobic metabolism.
Padmaja
G
G
Panikkar
K R
KR
D000818:Animals; D001921:Brain / Q000201:enzymology; D003486:Cyanides / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000378:metabolism; D008658:Inactivation, Metabolic; D007668:Kidney / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009570:Nitriles / Q000493:pharmacokinetics / Q000633:toxicity*; D011190:Potassium Cyanide / Q000493:pharmacokinetics / Q000633:toxicity*; D011817:Rabbits; D013466:Sulfurtransferases / Q000378:metabolism*; D013884:Thiosulfate Sulfurtransferase / Q000097:blood / Q000378:metabolism*; D001617:beta-Glucosidase / Q000097:blood / Q000378:metabolism
D003486:Cyanides; D009570:Nitriles; D007770:L-Lactate Dehydrogenase; D003576:Electron Transport Complex IV; D013466:Sulfurtransferases; D013884:Thiosulfate Sulfurtransferase; D008071:Lipoprotein Lipase; C021514:cyanogenic beta-glucosidase; D001617:beta-Glucosidase; C005091:linamarin; D011190:Potassium Cyanide