title: [A case of Zollinger-Ellison syndrome successfully treated with an H+-K+ ATPase inhibitor].
abstract: A case of Zollinger-Ellison syndromes in a fifty year-old male that was successfully treated with a H+-K+ ATPase inhibitor (Omeprazol) is reported. The patient underwent a partial gastrectomy in 1984, but had been suffering from multiple refractory stomal and jejunal ulcers after the operation. In 1987, hypergastrinemia (760 pg/ml) was detected, and the presence of gastrinomas in the pancreatic head accompanied by a multiple liver metastasis was subsequently confirmed by CT-angiography and by the gastrin level detected in percutaneous, transhepatic, portal venous samples. A secretin provocation test proved to be negative, and the ulcers resisted the H2-receptor antagonists, but the patient was successfully cured shortly after the administration of an H+-K+ ATPase inhibitor.
authors.affiliation: 1st Dept. of Medicine, Hamamatsu Univ. School of Med.
authors.forename: T
authors.initials: T
authors.lastname: Sakakibara
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: A
authors.initials: A
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kitanaka
authors.forename: E
authors.initials: E
authors.lastname: Kaneko
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D015408:Gastrinoma / Q000000981:diagnostic imaging / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D012633:Secretin; D014057:Tomography, X-Ray Computed; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000188:drug therapy*
chemical_list: D005755:Gastrins; D012633:Secretin; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole