Regulation of CA II and H+,K(+)-ATPase gene expression in canine gastric parietal cells.
Acid secretagogue-specific receptor activation in parietal cells triggers rapid and coordinate gene expression of gastric H+,K(+)-ATPase and of CA II. The rapid rise in steady-state levels of CA II mRNA is due to new transcription of the CA II gene in stimulated cells. Although the presumed function of CA II in activated parietal cells is to catalyze the generation of HCO3- from OH-, regulation of CA II gene expression appears to be independent of the generation of H+ (and OH-) through the action of H+,K(+)-ATPase.
Campbell
V W
VW
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0682.
Yamada
T
T
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000818:Animals; D002256:Carbonic Anhydrases / Q000235:genetics*; D004285:Dogs; D015971:Gene Expression Regulation, Enzymologic; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole / Q000494:pharmacology; D010295:Parietal Cells, Gastric / Q000201:enzymology*; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D002256:Carbonic Anhydrases; D009853:Omeprazole