Hypersensitivity to arginine of both B and D pancreatic cells in adult streptozotocin-diabetic rats.
Insulin and pancreatic somatostatin secretions were studied after stimulation with an arginine infusion (5 mmol/l) in isolated perfused pancreata of adult streptozotocin-diabetic rats. In the presence of 2.8 mmol/l glucose, arginine clearly stimulated insulin and somatostatin secretions in diabetic rats, whereas it was ineffective in normal rats. Thus, not only the B-cells, but also the D-cells of the pancreas from streptozotocin-diabetic rats are hypersensitive to arginine. The infusion of insulin (4 U/l) did not modify this hypersensitivity of the D-cells to arginine in pancreata of streptozotocin-diabetic rats.
Zerbib
A
A
Laboratoire de Pharmacologie, URA O599 du CNRS, Faculté de Médecine, Montpellier, France.
Ribes
G
G
Gross
R
R
Puech
R
R
Loubatières-Mariani
M M
MM
D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin; D001120:Arginine