Pentylenetetrazol kindling in mice.
Kindling with pentylenetetrazol to produce minimal and maximal convulsions was investigated in CF-1 mice. Like electrical kindling, the kindling effect was directly proportional to the dose or the intensity of the kindling stimulus. Similarly, the kindling effect was persistent, as was emphasized by the ability to kindle with an interdose interval of 3 days and by the convulsions produced by a challenge with pentylenetetrazol 30 days after withdrawal from the kindling treatment. The changes in excitability, associated with the kindling state, appeared to be relatively selective for pentylenetetrazol, because no changes in thresholds to either electroshock or administration of picrotoxin or N-methyl-DL-aspartate correlated temporally with the persistence of kindling. The influence of two anticonvulsant drugs, ethosuximide and cannabidiol, on kindling was also investigated. Both drugs blocked the development of kindling to pentylenetetrazol-induced minimal convulsions. Of these drugs, only ethosuximide raised the minimal convulsive threshold to pentylenetetrazol. Against pentylenetetrazol-induced kindling to maximal convulsions, only cannabidiol blocked kindling and only cannabidiol raised the maximal seizure threshold for pentylenetetrazol. Although the drugs modified the kindling effect, the mechanism of the interaction is not clear.
Karler
R
R
Department of Pharmacology, University of Utah School of Medicine, Salt Lake City 84132.
Murphy
V
V
Calder
L D
LD
Turkanis
S A
SA
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002185:Cannabidiol / Q000494:pharmacology; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051379:Mice; D016202:N-Methylaspartate; D018377:Neurotransmitter Agents / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology
D000927:Anticonvulsants; D001224:Aspartic Acid; D002185:Cannabidiol; D016202:N-Methylaspartate; D018377:Neurotransmitter Agents; D010433:Pentylenetetrazole; D010852:Picrotoxin