Is there evidence of a role of the phosphoinositol-cycle in the myocardium?
The recent findings on a more general involvement of phospholipids in signal transduction and on the different roles of inositolphospholipids in particular, thoroughly complicate research in this field. It becomes increasingly evident that measuring [3H]inositolphosphate formation alone will never provide insight into the complex machinery of cellular signalling. Certainly for the heart in which the role(s) of the inositolphospholipids is far from clarified, the novel trends provide new directions for research.
de Chaffoy de Courcelles
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Department of Biochemistry, Janssen Research Foundation, Beerse, Belgium.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D009206:Myocardium / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism* / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D015398:Signal Transduction
D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D011976:Receptors, Muscarinic