Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro.
The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.
Lewis
A G
AG
Dept of Medical Microbiology, University of Manchester, Medical School, UK.
Cleator
G M
GM
Klapper
P E
PE
Templeton
P P
PP
Longson
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005047:Etoposide / Q000494:pharmacology*; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014709:Vero Cells; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
D005047:Etoposide