title: The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner Lambert Co., Ann Arbor, MI 48105.
authors.forename: D J
authors.initials: DJ
authors.lastname: Schrier
authors.forename: M A
authors.initials: MA
authors.lastname: Adamchak
authors.forename: A M
authors.initials: AM
authors.lastname: Boctor
authors.forename: C R
authors.initials: CR
authors.lastname: Kostlan
authors.forename: D L
authors.initials: DL
authors.lastname: Flynn
authors.forename: J H
authors.initials: JH
authors.lastname: Jordan
authors.forename: M E
authors.initials: ME
authors.lastname: Lesch
authors.forename: G C
authors.initials: GC
authors.lastname: Okonkwo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D001169:Arthritis, Experimental / Q000378:metabolism; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors; D015237:Dinoprost / Q000096:biosynthesis; D004487:Edema / Q000139:chemically induced / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D015471:Leukemia, Basophilic, Acute / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D009161:Mycobacterium; D010636:Phenols / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000378:metabolism; D015054:Zymosan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D011720:Pyrazoles; C061325:PD 127443; D007975:Leukotriene B4; D002351:Carrageenan; D015054:Zymosan; D015237:Dinoprost; D001091:Arachidonate Lipoxygenases