[Postradiation changes of active ion transport systems of the CNS. The effect of superlethal doses of ionizing radiation on the Na,K pump in surviving brain slices].
Active potassium ion transport in surviving sections of rat brain was irreversibly inhibited 6 min, 1 h and 6 h following whole-body single X irradiation. At the same time, the accumulation of products of lipid peroxidation and phospholipase hydrolysis was followed up during the development of radiation pathology. The relationship was noted between the postirradiation changes in the physicochemical status of lipids of the membrane and the impairment of its transport function.
Dvoretskiĭ
A I
AI
Shainskaia
A M
AM
Anan'eva
T V
TV
Kulikova
I A
IA
Annenkova
S V
SV
D000818:Animals; D001693:Biological Transport, Active / Q000528:radiation effects; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D002490:Central Nervous System / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006868:Hydrolysis; D015227:Lipid Peroxidation / Q000528:radiation effects; D008563:Membrane Lipids / Q000378:metabolism / Q000528:radiation effects; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects; D010740:Phospholipases / Q000378:metabolism / Q000528:radiation effects; D015221:Potassium Channels / Q000378:metabolism / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015222:Sodium Channels / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014022:Tissue Survival / Q000528:radiation effects*
D008563:Membrane Lipids; D015221:Potassium Channels; D015222:Sodium Channels; D010740:Phospholipases
Postradiatsionnye izmeneniia v sistemakh aktivnogo transporta ionov v TsNS. Vliianie sverkletal'nykh doz ioniziruiushcheĭ radiatsii na Na,K-nasos v perezhivaiushchikh srezakh mozga.