[The possible effect of a ketotifen preparation on beta-receptor blockade].
Parallel clinico-pharmacological studies were carried out of ketotifen action in patients with atopic bronchial asthma and in an experimental model of beta-adrenergic blockade in guinea pigs. The results revealed that ketotifen acts on the beta-adrenergic blockade in the patients with atopic bronchial asthma and in the experimental model in guinea pigs. The ketotifen action on beta-adrenergic blockade resembles that of glucocorticosteroids in efficiency.
Kosturkov
G
G
Markov
M
M
Vŭlcheva
T
T
Popov
T
T
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D011943:Receptors, Adrenergic, beta; D007665:Ketotifen
Prouchvane na vŭzmozhniia efekt na preparata ketotifen vŭrkhu beta-retseptornata blokada.