Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.
The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na+,K+-ATPase beta-subunit. A partial structure of the beta 1-gene was determined, the coding part of which was completely homologous to cDNA of the Na+,K+-ATPase beta I-subunit from HeLa cells. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (beta psi) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the beta I-subunit cDNA from HeLa cells is about 88%.
Ushkaryov YuA
Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
Monastyrskaya
G S
GS
Broude
N E
NE
Nikiforova
N N
NN
Bessarab
D A
DA
Orlova MYu
Petrukhin
K E
KE
Modyanov
N N
NN
Sverdlov
E D
ED
D000818:Animals; D001483:Base Sequence; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D011544:Pseudogenes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D013552:Swine
D008565:Membrane Proteins; D000254:Sodium-Potassium-Exchanging ATPase