[The role of catecholaminergic synapses in the mechanisms of the formation of adaptation with the participation of polyphenol adaptogens].
The analysis of the role of catecholaminergic synapses in the process of adaptation showed that the main point of the influence of polyphenolic adaptogens was a catechol-O-methyltransferase. Inhibiting the latter, the polyphenolic adaptogens exert a correcting effect on catecholaminergic (mainly dopaminergic) synapses and prevent the transmitter from reduction in them.
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D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004347:Drug Interactions; D005419:Flavonoids; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D017983:Receptors, Catecholamine; D013550:Swimming
D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D006591:Hexobarbital
O roli katekholaminergicheskikh sinapsov v mekhanizme formirovaniia adaptatsiĭ pri uchastii polifenol'nykh adaptogenov.