title: Sequences of capsid protein VP1 of two type A foot-and-mouth disease viruses.
abstract: We have sequenced the nucleotides of the regions that encode the capsid protein VP1 of the foot-and-mouth disease viruses (FMDV) A5Bernbeuren/1984 and A Iran/1987. Amino acid sequences and secondary protein structures are provided. Both proteins consist of 212 amino acids. The sequences and secondary structures are compared to those of FMDV A22/CCCP/64, a strain previously endemic in the Near East. Nucleotide divergency among the three sequences is highest for FMDV A5Bernbeuren/1984 (18% compared to 13% for each other case). Thirty amino acid divergencies are observed between A22/CCCP/64 and A5 Bernbeuren/1984 or A Iran/1987, whereas the latter two differ by 27 residues. The secondary structures of all three proteins are different. A Iran/1987 is considered to belong to a thus far unknown subtype.
authors.affiliation: Federal Research Centre for Virus Diseases of Animals, Tübingen, Federal Republic of Germany.
authors.forename: O
authors.initials: O
authors.lastname: Marquardt
authors.forename: K H
authors.initials: KH
authors.lastname: Adam
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005537:Aphthovirus / Q000145:classification / Q000235:genetics*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D002478:Cells, Cultured; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D004279:DNA, Viral; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012367:RNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping; D013045:Species Specificity
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; D012367:RNA, Viral; C442501:VP1 protein, Foot-and-mouth disease virus; D004247:DNA