title: Nerve growth factor receptor immunoreactivity in human benign peripheral nerve sheath tumor.
abstract: In situ expression of nerve growth factor (NGF) receptors in human dermal and plexiform neurofibroma, schwannoma and traumatic neuroma was examined by an immunohistochemical method using a monoclonal anti-human NGF receptor antibody. Immunoreactivity for the NGF receptor was observed on the principal cells of both neurofibroma and schwannoma. Immunostaining by the anti-S-100 beta protein antibody in adjacent sections suggested that the vast majority of NGF receptor-positive cells were also positive for S-100 beta protein. In traumatic neuroma, staining for the NGF receptor was more intense in the perineurium than in the endoneurial cells.
authors.affiliation: Fourth Department of Internal Medicine, Aichi Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: G
authors.initials: G
authors.lastname: Sobue
authors.forename: T
authors.initials: T
authors.lastname: Mitsuma
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hashizume
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000378:metabolism*; D009455:Neurofibroma / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor
chemical_list: D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor