[Effect of calcium-channel blockers on human thrombocyte aggregation induced by alpha-adrenoreceptor agonists].
A comparative study of the effects of calcium channel blockers nifedipine and verapamil on platelet aggregation in healthy donors induced by adrenaline. A partial agonist of alpha 2-adrenoreceptors clofelin and also clofelin in combination with the threshold concentrations of ADP inducing aggregation was performed. It was found that verapamil is a more potent inhibitor of platelet aggregation induced by adrenaline as compared with nifedipine inhibiting this process only at high concentrations. The aggregation-inducing effect of a partial agonist of alpha 2-adrenoreceptors clofelin is eliminated at low concentrations in the aggregating mixture of nifedipine than verapamil.
Ivleva
A Ia
AIa
Kobalava
Zh D
ZhD
Moiseev
V S
VS
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D002121:Calcium Channel Blockers; D010975:Platelet Aggregation Inhibitors
Vliianie blokatorov kal'tsievykh kanalov na agregatsiiu trombotsitov cheloveka, indutsirovannuiu agonistami al'fa-adrenoretseptorov.