title: Nedocromil sodium and sensory nerves in the dog lung.
abstract: The effect of nedocromil sodium on the main sensory nerve types in the dog lung has been studied. Nedocromil sodium (0.1, 1.0 and 10 mg/kg i.v.) did not stimulate or inhibit the discharge pattern of pulmonary stretch receptors, rapidly adapting irritant receptors or pulmonary C-fibre endings. Nedocromil sodium 5 micrograms/kg given into the aortic arch did, however, stimulate bronchial C-fibre endings. These endings were also stimulated when the drug was given by aerosol. The possibility that nedocromil sodium suppresses cough in the dog by stimulation of bronchial C-fibre endings is discussed.
authors.affiliation: Fisons plc, Pharmaceutical division, Loughborough, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Jackson
authors.forename: A A
authors.initials: AA
authors.lastname: Norris
authors.forename: R P
authors.initials: RP
authors.lastname: Eady
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs; D005260:Female; D007509:Irritants / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000294:innervation*; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects; D009186:Myelin Sheath / Q000502:physiology; D017835:Nedocromil; D009411:Nerve Endings / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007509:Irritants; D015363:Quinolones; D017835:Nedocromil