title: Effects of bestatin on intrauterine growth of rat fetuses.
abstract: Pregnant Wistar rats were injected with bestatin, a specific inhibitor of aminopeptidase M. Placental aminopeptidase M activity was inhibited by injection of bestatin, and fetal body weight was statistically lower than that in the saline-injected or control group. Our present data suggest that placental aminopeptidase M plays an important role in fetal growth.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Furuhashi
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
authors.forename: O
authors.initials: O
authors.lastname: Kurauchi
authors.forename: M
authors.initials: M
authors.lastname: Kasugai
authors.forename: Y
authors.initials: Y
authors.lastname: Tomoda
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology; D018826:CD13 Antigens; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000196:embryology; D008861:Microsomes / Q000201:enzymology; D010920:Placenta / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D018826:CD13 Antigens; D007930:Leucine; C012211:ubenimex