Eicosanoid production and cell accumulation induced by intrapleural injection of sodium arachidonate in the rat. Characterization of the model.
Gans
K R
KR
E. I. du Pont de Nemours & Co., Inc., Medical Products Department, Wilmington, DE 19898.
Lundy
S R
SR
Arner
E C
EC
Munzer
D A
DA
Dowling
R L
RL
Galbraith
W
W
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology*; D002452:Cell Count; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids / Q000096:biosynthesis*; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D010994:Pleura / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010998:Pleurisy / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D006893:Hydroxyeicosatetraenoic Acids; D016859:Lipoxygenase Inhibitors; D007975:Leukotriene B4; D016718:Arachidonic Acid; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D007770:L-Lactate Dehydrogenase; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases