title: Localization of the gene for classic Alport syndrome.
abstract: The inheritance of Alport syndrome has been controversial for 30 years because no clear diagnostic criteria were established to define a clinically homogeneous group of patients. In this study, 41 families with "classic" Alport syndrome were identified and studied. All the pedigrees are compatible with X-linked inheritance. A formal genetic study confirmed linkage to probe S21 (DXS17), with a maximum LOD score of 4.72 at a recombination frequency of 0.06.
authors.affiliation: Paediatric Research Unit, United Medical School, Guy's Hospital, London Bridge, United Kingdom.
authors.forename: F A
authors.initials: FA
authors.lastname: Flinter
authors.forename: S
authors.initials: S
authors.lastname: Abbs
authors.forename: M
authors.initials: M
authors.lastname: Bobrow
mesh_terms: D002874:Chromosome Mapping; D015342:DNA Probes; D005260:Female; D006801:Humans; D008126:Lod Score; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
chemical_list: D015342:DNA Probes