Radioprotection of C3H mice by recombinant human interleukin-1 alpha.
High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the optimum times was also observed in the cell kinetic behaviour of GM-CFC in the bone marrow. In previous studies it was reported that less radioprotection was found in C3H/HeN mice pretreated with IL-1. This may not be the case with a higher dose of IL-1.
Wu
S G
SG
Hospital, National Institute of Radiological Sciences, Chiba City, Japan.
Tuboi
A
A
Miyamoto
T
T
D000818:Animals; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008809:Mice, Inbred C3H; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins; D013997:Time Factors; D014965:X-Rays
D007375:Interleukin-1; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins