Neuroleptic-valproic acid combination in treatment of psychotic symptoms: a three-case report.
Valproic acid is infrequently used for treatment of psychosis. Three consecutive patients with severe neuroleptic-resistant psychotic symptoms responded dramatically to the combination of valproic acid and neuroleptics. All three had normal EEGs and CT scans. Outpatient follow-up showed that the combination was effective in maintaining remissions.
Wassef
A
A
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77550.
Watson
D J
DJ
Morrison
P
P
Bryant
S
S
Flack
J
J
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006212:Hallucinations / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000188:drug therapy; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D013881:Thioridazine / Q000627:therapeutic use; D013888:Thiothixene / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D014635:Valproic Acid; D013888:Thiothixene; D013881:Thioridazine