Safety of oral contraceptives related to steroid content: a critical review.
In 1980, an FDA advisory committee found inconclusive the evidence that the safety of oral contraceptives was related to their steroid content. In 1988, another FDA advisory committee examining the same evidence concluded that there is a trend to suggest such a relationship. The present review critically examines the published evidence and concludes that there is no scientific support for the suggestion that higher-dose oral contraceptives are less safe. Nevertheless, such products are no longer being made available in the United States.
Sturtevant
F M
FM
G.D. Searle & Co. Skokie, Illinois.
D003277:Contraceptives, Oral, Combined / Q000009:adverse effects* / Q000592:standards; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects* / Q000592:standards; D005060:Europe; D005260:Female; D006801:Humans; D011372:Progestins / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards; D014481:United States; D014486:United States Food and Drug Administration
D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D011372:Progestins