Alpha-adrenoceptors in human and animal cerebral arteries: alterations after sympathetic denervation and subarachnoid hemorrhage.
Vasospasm of cerebral arteries in patients with subarachnoid hemorrhage frequently presents severe clinical problems resulting from cerebral ischemia, but the pathogenesis of vasospasm is still poorly understood. The contractile response of human cerebral arteries to noradrenaline is larger than the responses in other species. Neurogenic factors controlling brain circulation may play an important role in pathological conditions such as subarachnoid hemorrhage. Motohatsu Fujiwara and colleagues review species variations of alpha-adrenoceptors in cerebral arteries and their alterations after surgical sympathectomy. They compare these changes to those occurring in human cerebral arteries following subarachnoid hemorrhage and discuss their relationship to vasospasm.
Fujiwara
M
M
Tsukahara
T
T
Taniguchi
T
T
D000818:Animals; D002536:Cerebral Arteries / Q000648:ultrastructure*; D006801:Humans; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology; D013562:Sympathectomy
D011942:Receptors, Adrenergic, alpha