[Excitation-contraction coupling in the smooth muscle of the femoral artery under the effects of noradrenaline].
Noradrenaline (5 x 10(-8) - 10(-5) M) induced a dose-dependent contraction of muscle strips from rabbit femoral artery. At concentrations higher than 10(-7) M noradrenaline evoked also a depolarization of smooth muscle cells due to an increase in sodium and/or chloride permeability of the membrane. Repolarization of the membrane to original level by inwardly applied current resulted in restoration of membrane resistance and partial relaxation of noradrenaline-evoked contraction. The same part of contraction was also blocked by verapamil. In calcium-free EGTA-containing solution noradrenaline induced only a small transient contraction. These findings indicate that noradrenaline-activated sodium (or chloride) permeability is voltage dependent. Noradrenaline evoked contraction is activated by calcium ions entered the cell through receptor-operated and partly through voltage-operated calcium channels.
Gurkovskaia
A V
AV
Gokina
N I
NI
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D002199:Capillary Permeability; D002712:Chlorides / Q000378:metabolism; D005263:Femoral Artery; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology
D015220:Calcium Channels; D002712:Chlorides; D012964:Sodium; D014700:Verapamil; D009638:Norepinephrine
Sopriazhenie vozbuzhdeniia-sokrashcheniia v gladkoĭ myshtse bedrennoĭ arterii pri deĭstvii noradrenalina.