title: Does medical therapy cure female stress incontinence?
abstract: Forty-four consecutive female patients, who were scheduled for operation for genuine stress incontinence but instead treated pharmacologically with an alpha-agonist or placebo for 3-4.5 months, were evaluated after a median observation period of 30 months. Ten patients (23%) underwent colposuspension. Fourteen patients (32%) claimed to be continent or so much improved that further treatment was considered unnecessary by the patients themselves. Of the remaining 20 patients who still claimed to have stress incontinence, 11 (25%) preferred to resume the pharmacological treatment whereas 9 patients (20%) had not decided whether they wanted further treatment. These results suggest that some operations for stress incontinence may be avoided by introduction of a standard trial of medical therapy prior to intended surgical intervention.
authors.affiliation: Department of Obstetrics and Gynaecology, Kolding Hospital, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Lose
authors.forename: E
authors.initials: E
authors.lastname: Diernaes
authors.forename: P
authors.initials: P
authors.lastname: Rix
mesh_terms: D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D009655:Octopamine / Q000031:analogs & derivatives*; D010627:Phenethylamines / Q000627:therapeutic use*; D010919:Placebos; D013997:Time Factors; D014550:Urinary Incontinence, Stress / Q000188:drug therapy*
chemical_list: D000316:Adrenergic alpha-Agonists; D010627:Phenethylamines; D010919:Placebos; D009655:Octopamine; D015078:2-Hydroxyphenethylamine; C005310:norfenefrine