Identification of a germ line transcript from the unrearranged kappa gene in human B cells.
A novel kappa immunoglobulin-hybridizing mRNA in cell lines derived from human B cells arrested at several stages of development has been identified. Hybridization studies demonstrate that this 1.5-kilobase mRNA species is the spliced product of a precursor germ line transcript initiating upstream of the unrearranged JKappa locus.
Martin
D J
DJ
Department of Biochemistry, University of Iowa, Iowa City 52242.
Van Ness
B G
BG
D001402:B-Lymphocytes / Q000502:physiology*; D005854:Germ Cells / Q000502:physiology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D015183:Restriction Mapping; D014158:Transcription, Genetic
D007145:Immunoglobulin kappa-Chains; D012333:RNA, Messenger; D011061:Poly A