title: KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Mollisia ventosa.
abstract: Novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase were isolated from the culture broth of a fungus, Mollisia ventosa KAC-1148. They were designated as KS-504a, KS-504b and KS-504d. A degradative product of KS-504a, called KS-504e, was also isolated and found to inhibit the enzyme. The 50% inhibitory concentration (IC50) values of KS-504a, KS-504b, KS-504d and KS-504e for bovine brain enzyme were 122, 109, greater than 500 and 139 microM, respectively.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: I
authors.initials: I
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Yasuzawa
authors.forename: H
authors.initials: H
authors.lastname: Sano
authors.forename: H
authors.initials: H
authors.lastname: Kase
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002118:Calcium / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D003517:Cyclopentanes / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D005658:Fungi / Q000032:analysis; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; C063094:KS 504d; C063096:KS 504e; C063093:KS 504a; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D002118:Calcium