Effect of naloxone on acute ethylic intoxication. An EEG study.
EEG recording has been used to evaluate in cats the effect of naloxone on acute ethylic intoxication (AEI). Naloxone was administered both before and during the course of AEI. Results of the experiment showed that administration of naloxone before the AEI potentiates the toxic effect of alcohol. However, the administration of naloxone in a continuous way along the course of AEI significantly diminished the toxic effect of alcohol.
Dawid-Milner
M S
MS
Departamento de Fisiología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Díaz-Calavia
E J
EJ
Fernández del Moral
R
R
Santidrián
S
S
Jiménez-Vargas
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D004347:Drug Interactions; D004569:Electroencephalography; D004723:Endorphins / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D000431:Ethanol