[Role of adrenoreceptors in the activation of the mouse hypothalamo-pituitary testicular complex induced by the presence of a female].
A study was made of the role of the adrenergic mechanisms in the activation of endocrine testicular function of CBA/Lac and A/He male mice induced by the presence of a female in estrus without any tactile contact with a male. The alpha 1-adrenoreceptor blocker prazosin inhibited completely an increase in the peripheral blood plasma testosterone level caused by the receptive female challenge. At the same time, optimol blockade of beta 2-adrenoreceptors markedly increased the stimulating effect of the receptive female presence on the blood testosterone level. The expression of optimol action on the blood testosterone level depended on a male genotype. A conclusion was made that during sexual motivation in male mice caused by the presence of a receptive female, the stimulatory effects on testicular endocrine function were produced through the alpha 1-adrenoreceptors and the inhibitory effects were produced through the beta 2-adrenoreceptors.
Naumenko
E V
EV
Amstislavskaia
T G
TG
Osadchuk
A V
AV
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004971:Estrus; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008808:Mice, Inbred CBA; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D013739:Testosterone
Rol' adrenoretseptorov v aktivatsii gipotalamo-gipofizarno- semennikovogo kompleksa mysheĭ, vyzvannoĭ prisutstviem samki.