Effect of Escherichia coli infection on growth and protein metabolism in broiler chicks (Gallus domesticus).
1. A controlled experimental Escherichia coli infection was developed in broiler chicks. 2. Infection with E. coli significantly reduced feed intake, altered growth of the whole body, eviscerated carcass, skeletal muscles, heart and liver. Organ weight and/or the proportions of organs within the body were affected. 3. Protein accumulation in the eviscerated carcass, extensor digitorum communis and sartorius muscles was severely inhibited by infection, and to a greater extent than body weight. 4. Failure of muscle tissue to accumulate protein was associated with a significant decline in protein synthesis, when measured in vitro (-48%; P less than 0.05) and in vivo (-42%; P less than 0.001). Protein degradation also declined (-28.7%), but to a smaller extent than protein synthesis. 5. Although the infected chicks showed no viable bacteria at day 12 after infection, chicks did not reach the same body weight as controls by day 30 after infection.
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Department of Animal Science, University of Alberta, Edmonton, Canada.
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D000818:Animals; D001823:Body Composition; D001835:Body Weight; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism / Q000382:microbiology; D004435:Eating; D004927:Escherichia coli Infections / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D011201:Poultry Diseases / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology; D011506:Proteins / Q000378:metabolism
D009124:Muscle Proteins; D011506:Proteins