Metabolism of N-nitroso-hydroxyethyl-alkylamine phosphate esters in the rat.
The metabolism of 1-(N-methyl-N-nitrosamino)-ethylphosphate and 1-(N-ethyl-N-nitrosamino)-ethylphosphate in the rat was investigated. The determination of blood clearance, organ clearance, excretion of parent compounds in the urine and the exhalation of radiolabeled CO2 originating from a nitrosaminophosphate demonstrated a rapid metabolism of the compounds. The high activity of alkaline phosphatase in kidney caused a very rapid degradation of the nitrosamino phosphates in kidney homogenate, whereas the compounds were relatively stable in liver homogenate and serum. We, therefore, suggest a rapid degradation of such nitrosamino conjugates, if they are formed at all, in vivo.
Frank
N
N
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, F.R.G.
Frei
E
E
Wiessler
M
M
D000818:Animals; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009602:Nitrosamines / Q000378:metabolism*; D010755:Organophosphates / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D009602:Nitrosamines; D010755:Organophosphates; D009943:Organophosphorus Compounds; C060349:1-(N-methyl-N-nitrosoamino)ethyl phosphate; C060350:1-(N-ethyl-N-nitrosamino)ethyl phosphate; D010744:Phosphoric Monoester Hydrolases