Role of chloride in hypertonicity-induced contractures of rat soleus muscle.
The role of chloride in contractures induced in rat soleus muscle by mannitol-, sucrose- or urea-containing hypertonic solutions was investigated. Replacement of chloride with nitrate, sulphate or perchlorate reduced the amplitude of mannitol- and sucrose-induced contractures, and the first phase of contractures induced by urea. Addition of 9-anthracene carboxylic acid had similar effects. The presence of diazepam increased the amplitude of 'hypertonic' contractures. The results show that chloride is important in the development of hypertonic contractures.
Bruton
J D
JD
Department of Physiology, Chinese University of Hong Kong, Shatin, New Territories.
D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D005260:Female; D006982:Hypertonic Solutions; D008353:Mannitol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009566:Nitrates / Q000378:metabolism; D010472:Perchlorates / Q000378:metabolism; D051381:Rats; D013395:Sucrose / Q000494:pharmacology; D013431:Sulfates / Q000378:metabolism; D013997:Time Factors; D014508:Urea / Q000494:pharmacology
D002712:Chlorides; D006982:Hypertonic Solutions; D009566:Nitrates; D010472:Perchlorates; D013431:Sulfates; D008353:Mannitol; D013395:Sucrose; D014508:Urea