[Thymus hormones--precursors of new psychoneuromodulatory peptides].
The influence of thymic hormone's short fragments: thymopentin or T-5 (RKDVY), RKD and SKD, on behaviour and neurochemical processes (contents of GABA and monoamines in the brain and adrenals, plasma corticosterone), was investigated. The 100 and 500 micrograms/kg doses i.p. prevented alterations in rat's brain GABA content and plasma corticosterone level, as well as elicited anxiolytic activity in a conflict test. T-5 exerted antidepressant activity, too. SKD potentiated the haloperidol-induced catalepsy. The data obtained suggest a multicomponent (CNS-activating and inhibiting) mechanism of action of the thymic hormone fragments. These fragments seem to be formed endogenously during thymic hormone bioprocessing and may act as regulatory neuropeptides.
Klusha
V E
VE
Mutsenietse
R K
RK
Liepa
I R
IR
Svirskis
Sh V
ShV
Andermanis
A V
AV
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D001522:Behavior, Animal / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008807:Mice, Inbred BALB C; D009479:Neuropeptides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D009479:Neuropeptides; D009842:Oligopeptides; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C060784:seryl-lysyl-aspartic acid; C045801:RGH 0205; D016305:Thymopentin; D003975:Diazepam
Timusnye gormony--predshestvenniki novykh psikhoneĭromoduliruiushchikh peptidov.