Enalapril attenuates glomerular hyperfiltration following a meat meal.
It has been shown that the glomerular filtration rate increases after a meat meal. We examined in humans whether enalapril, which has been shown to decrease glomerular capillary pressure in rats with chronic renal failure, could attenuate the renal response to a meat meal. Twelve healthy volunteers were studied after an oral protein load, 1.5 g/kg body weight, as lean cooked beef meat, and on a separate day, after eating the same meal with prior oral intake of enalapril. On the control day, creatinine clearance increased from 114.3 +/- 4.7 before the meal to 137.1 +/- 4.7 ml/min/1.73 m2 after the meal (p less than 0.001). On the enalapril intake day, creatinine clearance increased from 113.7 +/- 5.6 before the meal to 128.3 +/- 5.8 ml/min/1.73 m2 after the meal (p less than 0.01). However, the mean increase in creatinine clearance was lower on the enalapril intake than on the control day (14.0 +/- 4.3 vs. 21.0 +/- 4.1%, p less than 0.05). Mean arterial pressure before the meal was lower on the enalapril intake day than on the control day (76.2 +/- 3.5 vs. 84.2 +/- 3.6, p less than 0.01). Likewise, postprandial mean arterial pressure was lower on the enalapril day compared with the control day (69.9 +/- 2.8 vs. 78.5 +/- 3.7, p less than 0.01). We conclude that enalapril blunts the hyperfiltration which follows a meat meal.
Chagnac
A
A
Department of Nephrology, Hasharon Hospital, Petah-Tiqva, Tel-Aviv University Medical School, Israel.
Gafter
U
U
Zevin
D
D
Hirsch
Y
Y
Markovitz
I
I
Levi
J
J
D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D003404:Creatinine / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology*; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008460:Meat; D012964:Sodium / Q000652:urine
D004044:Dietary Proteins; D004656:Enalapril; D012964:Sodium; D003404:Creatinine