The effects of prenatal exposure to delta-9-tetrahydrocannabinol on the rest-activity cycle of the preweanling rat.
Either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered from Day 2 through Day 22 of gestation. Pair-fed (0 mg/kg) and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether delta-9-THC produces effects on the rest-activity cycle of the offspring, groups of 3 littermates from each of the treated and control groups were tested for an 8 hr observation period on electronic activity monitors at 17, 22 and 30 days of age. Whereas all treated and control groups showed age-dependent changes in activity, neither activity level nor the rest-activity pattern were affected by delta-9-THC. These findings are discussed in relation to neurobehavioral studies of activity changes following prenatal exposure to cannabis.
Hutchings
D E
DE
New York State Psychiatric Institute, Department of Developmental Psychobiology, New York 10032.
Gamagaris
Z
Z
Miller
N
N
Fico
T A
TA
D000818:Animals; D004326:Drinking / Q000187:drug effects; D013759:Dronabinol / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D013759:Dronabinol