Methoxatin (PQQ), coenzyme for copper-dependent amine and mixed-function oxidation in mammalian tissues.
The newly discovered coenzyme PQQ can now be measured at picomole levels with redox cycling methods developed in our laboratory. PQQ-peptides have been obtained from digests of the copper quinoenzymes, diamine oxidase, lysyl oxidase and dopamine-beta-hydroxylase. PQQ is present in egg yolk and milk, suggesting its immediate availability for developing embryos and newborn animals. We suggest that PQQ, when exposed in traumatized, ischemic, inflammed or pathological tissues, may catalyze the formation of large amounts of superoxide and should be considered as a source of oxidative stress when planning pharmacotherapeutic intervention. PQQ and quinoproteins play a role in the redox metabolism and structural integrity of cells and tissues.
Paz
M A
MA
Children's Hospital, Boston, MA.
Flückiger
R
R
Torrelio
B M
BM
Gallop
P M
PM
D000588:Amines / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D003067:Coenzymes / Q000378:metabolism / Q000502:physiology*; D003300:Copper / Q000494:pharmacology*; D008322:Mammals; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D045542:PQQ Cofactor; D015363:Quinolones / Q000378:metabolism / Q000494:pharmacology*
D000588:Amines; D003067:Coenzymes; D015363:Quinolones; D045542:PQQ Cofactor; D003300:Copper; D006899:Mixed Function Oxygenases