title: Evaluation of xylazine hydrochloride as the sole immobilizing agent in moose and caribou--and its subsequent reversal with idazoxan.
abstract: Xylazine hydrochloride was used as the sole immobilizing agent in moose and caribou. The animals were free-ranging and immobilization was accomplished from a helicopter using powered darts. Following a period of immobilization during which radiotelemetry collars were fitted, the animals were revived using idazoxan (RX 781094) or its methoxy analogue RX 821002. Xylazine was administered at dose rates of approximately 3.0 mg/kg and 5.0 mg/kg to the moose and caribou, respectively. Moose received 430 +/- 27 mg of xylazine and a mean dose of 10 mg idazoxan (RX 781094). Caribou received 485 +/- 30 mg xylazine and a mean dose of 4 mg idazoxan (RX 821002). This technique gave adequate immobilization with rapid recovery of consciousness in both species.
authors.affiliation: Department of Clinical Studies, University of Guelph, Ontario, Canada.
authors.forename: T J
authors.initials: TJ
authors.lastname: Doherty
authors.forename: D P
authors.initials: DP
authors.lastname: Tweedie
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D003670:Deer; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D004341:Drug Evaluation / Q000662:veterinary; D019329:Idazoxan / Q000031:analogs & derivatives; D007103:Immobilization; D012053:Reindeer; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D004147:Dioxins; D013843:Thiazines; D014991:Xylazine; C058525:2-methoxyidazoxan; D019329:Idazoxan