[Plasma level of cyclic nucleotides in patients with congestive heart failure and their clinical significance].
Plasma concentrations of cyclic nucleotides were determined by radioimmunoassay in 196 cardiac patients. The results showed that plasma concentrations of cyclic AMP and cyclic GMP increased with the deterioration of cardiac function. Plasma cyclic GMP concentrations were correlated positively to the cardiothoracic ratios (CTR), PEP/LVET, and the intracardiac diameters measured by echocardiography respectively (r = 0.55 r = 0.50, and r = 0.55, P less than 0.001), and were correlated negatively to the left ventricular ejection fractions (LVEF) and LV short axis shortenings (LVSAS) (r = -0.53 and r = -0.50 respectively, P less than 0.001). There were only weak correlations between plasma cyclic AMP concentrations and CTR, PEP/LVET ratios, LVEF and LVSAS (r = 0.35, r = 0.38, r = 0.28, and r = -0.31, respectively, P less than 0.01). The correlations between plasma cyclic GMP concentrations and mean pulmonary artery pressures (r = 0.48, P less than 0.05) and mean left atrial pressures (r = 0.55, P less than 0.01) were also significant. In patients who had received cardioversion and valve replacement, plasma cyclic GMP concentrations decreased significantly. Thus the plasma concentrations of cyclic nucleotides could be used as a useful parameter in evaluation of cardiac function and therapeutic effect.
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D000328:Adult; D000368:Aged; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D004554:Electric Countershock; D005260:Female; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged
D000242:Cyclic AMP; D006152:Cyclic GMP