Long-term complete chimerism and stable hematopoiesis in beagles after fetal liver hematopoietic stem cell transplantation.
Karyotype analysis of bone marrow cells was performed from 6 Beagles that had received sex-mismatched fetal liver hematopoietic stem cell grafts 2.4 to 6.5 years earlier. Two dogs received dog leukocyte antigen-matched fetal liver cells and 4 received dog leukocyte antigen-mismatched cells. In each dog, all 25 evaluated metaphase spreads were of donor genotype. All dogs had normal hemograms and repopulation of bone marrow and no dog developed graft-vs-host disease.
Cain
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Laboratory for Energy-Related Health Research, University of California, Davis 95616.
Champlin
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D000818:Animals; D001854:Bone Marrow Cells; D002678:Chimera; D004285:Dogs / Q000097:blood*; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D007621:Karyotyping; D008099:Liver / Q000166:cytology / Q000196:embryology*