Inherited susceptibility to colorectal cancer.
Colorectal cancer and its potential precursor, adenomatous polyps, tend to aggregate in families, but it is not clear why. Heritability is established for only rare colorectal cancers, some prominently involving polyposis. Preliminary studies suggest, however, that susceptibility to the common colorectal cancer precursors, "sporadic" adenomatous polyps, is also inherited.
Burt
R W
RW
University of Utah School of Medicine, Salt Lake City.
D000236:Adenoma / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004198:Disease Susceptibility; D005838:Genotype; D014943:Global Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009154:Mutation; D010375:Pedigree; D012307:Risk Factors; D014589:Utah