title: Brain metabolites as 1H NMR markers of neuronal and glial disorders.
abstract: 1H NMR spectroscopy of human brain in vivo can be used to detect a number of cerebral metabolites including N-acetylaspartate, creatine + phosphocreatine and choline-containing compounds. We have used 1H NMR spectroscopy to analyse these signals in (i) biopsy material from both normal human brain and astrocytomas, and (ii) primary astrocyte cultures. On the basis of this analysis, we conclude that in vivo 1H NMR spectroscopy could play an important clinical role in the non-invasive assessment of neuronal degeneration and proliferation of non-neuronal cells.
authors.affiliation: Department of Neurological Surgery, Institute of Neurology, London, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Gill
authors.forename: R K
authors.initials: RK
authors.lastname: Small
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
authors.forename: P
authors.initials: P
authors.lastname: Patel
authors.forename: R
authors.initials: R
authors.lastname: Porteous
authors.forename: N
authors.initials: N
authors.lastname: Van Bruggen
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: R A
authors.initials: RA
authors.lastname: Kauppinen
authors.forename: S R
authors.initials: SR
authors.lastname: Williams
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis*; D005909:Glioblastoma / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011919:Rats, Inbred Strains