title: Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker.
abstract: A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).
authors.affiliation: U.184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.
authors.forename: R
authors.initials: R
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
authors.forename: A
authors.initials: A
authors.lastname: Seck
authors.forename: C
authors.initials: C
authors.lastname: Tommasi-Davenas
authors.forename: A J
authors.initials: AJ
authors.lastname: Driesel
authors.forename: K
authors.initials: K
authors.lastname: Olek
authors.forename: K H
authors.initials: KH
authors.lastname: Grzeschik
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: J L
authors.initials: JL
authors.lastname: Mandel
authors.forename: A
authors.initials: A
authors.lastname: Hanauer
mesh_terms: D002899:Chromosomes, Human, Pair 9; D015252:Deoxyribonucleases, Type II Site-Specific; D005621:Friedreich Ataxia / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007370:Interferon Type I / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers; D007370:Interferon Type I; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases