Effects of long-term xamoterol therapy on the left ventricular mechanical efficiency in patients with ischemic heart disease.
Myocardial oxygen uptake and an index of mechanical left ventricular efficiency were determined in basal conditions or during prolonged therapy with the new beta 1-adrenoceptor partial agonist xamoterol in 16 patients with mild to moderate ischemic heart failure. During xamoterol therapy, left ventricular end-diastolic pressure decreased from 24.4 +/- 6.5 to 17.8 +/- 8.6 mm Hg (P less than 0.01) and the isovolumic index of inotropic state (dP/dt)/DP40 increased by 14% (P less than 0.01). The heart rate increased slightly and the mean systolic and peak systolic wall stress also tended to increase (+ 7%; NS) but myocardial oxygen uptake (14.1 vs 14.7 ml/min; NS) and the index of efficiency (8.77 +/- 3.44 to 8.82 +/- 4.27; NS) were not significantly modified. In conclusion, prolonged therapy with xamoterol was not accompanied by a deterioration in the mechanical efficiency of the ventricle, even in patients with ischemic heart disease.
Pouleur
H
H
Department of Physiology, University of Louvain, Brussels, Belgium.
van Eyll
C
C
Etienne
J
J
van Mechelen
H
H
Vuylsteke
A
A
Rousseau
M F
MF
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D011412:Propanolamines / Q000494:pharmacology*; D017307:Xamoterol
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D017307:Xamoterol