Two different forms of endothelin receptors in rat lung.
We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with 125I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.
Masuda
Y
Y
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Miyazaki
H
H
Kondoh
M
M
Watanabe
H
H
Yanagisawa
M
M
Masaki
T
T
Murakami
K
K
D000345:Affinity Labels; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003432:Cross-Linking Reagents; D016232:Endothelins; D008168:Lung / Q000378:metabolism*; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin
D000345:Affinity Labels; D003432:Cross-Linking Reagents; D016232:Endothelins; D010455:Peptides; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin