[Activation in vivo of the collagenase of Clostridium histolyticum by erythromycin lactobionate].
The authors demonstrate a previously not described increase, in vivo, in a mean proportion of 70%, of the enzymatic activity of the clostridium collagenase in rats by erythromycin lactobionate. The pathogenesis of this phenomenon cannot yet be explained.
Warter
A
A
Clinique Médicale A, CHU, Strasbourg.
Schirardin
H
H
Warter
J
J
D000818:Animals; D003013:Clostridium / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003012:Microbial Collagenase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
C010948:erythromycin lactobionate; D004917:Erythromycin; D003012:Microbial Collagenase
Activation in vivo de la collagénase de Clostridium histolyticum par le lactobionate d'érythromycine.