[Interaction of the ligand molecules with the membrane receptors of tumor cells].
The mechanism of the ligand molecule interaction with cell membrane receptors is considered. The equation is obtained which describes dynamics of change in the number of ligand-receptor complexes on membranes with their constant internalization. It is shown that the in vivo internalization leads to saturation of the cell surface with the ligand-receptor complexes, the ligand concentrations being less than Kd. Theoretical conclusions are compared with the experimental data.
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D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008024:Ligands; D008433:Mathematics; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D008024:Ligands; D011956:Receptors, Cell Surface
Vzaimodeĭstvie molekul liganda s retseptorami membran opukholevykh kletok.