Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes.
Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.
Simonsson
P
P
Department of Psychiatry and Neurochemistry, Lund University, Sweden.
Hansson
E
E
Alling
C
C
D001253:Astrocytes / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D006868:Hydrolysis; D007295:Inositol Phosphates / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000378:metabolism*
D007295:Inositol Phosphates; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D011985:Receptors, Serotonin; D000431:Ethanol; D011493:Protein Kinase C