Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.
A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.
Harris
S C
SC
Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.
Wallace
J E
JE
Foulds
G
G
Rinaldi
M G
MG
D002849:Chromatography, Gas; D015725:Fluconazole; D006801:Humans; D007202:Indicators and Reagents; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D007202:Indicators and Reagents; D014230:Triazoles; D015725:Fluconazole