[An experimental study on the contents of enkephalins in the cerebrospinal fluid in rabbits with unilateral destructive lesions produced in the substantia nigra and their relation to the regulation of MIF-1].
The changes of the contents of enkephalins in cerebrospinal fluid (CSF) and the action of MIF-1 in rabbit experimental models of Parkinson's disease were studied. In the experiment, the rabbits received injection of 6-hydroxydopamine (6-OH DA) into the unilateral substantia nigra. The contents of Met-enkephalin (MEK) and Leuenkephalin (LEK) in the CSF of the fourth ventricles of the normal control rabbits and those with destructive lesions in the substantia nigra were determined with radio-immunoassay. The concentrations of MEK and LEK in CSF of the rabbit models increased markedly to 14.3 and 28.2 folds in the controls respectively. The increased enkephalin content in CSF could be reduced to the normal level by intravenous administration of MIF-I. The results indicated that the action of MIF-I may be one of the important factors in alleviating the symptoms of parkinsonian patients.
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D000818:Animals; D004743:Enkephalin, Leucine / Q000134:cerebrospinal fluid*; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid*; D005260:Female; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D010302:Parkinson Disease, Secondary / Q000134:cerebrospinal fluid* / Q000209:etiology; D011817:Rabbits; D013378:Substantia Nigra
D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D009075:MSH Release-Inhibiting Hormone