Central adrenoceptors and basal prolactin release in the rat.
The influence of the central adrenergic system on basal prolactin secretion was investigated in the rat. Several selective adrenoceptor blockers were centrally administered and their effects on prolactin secretion were observed. Blockade of beta-1 receptors by practolol, beta-2 receptors by IPS 339 and alpha-2 receptors by DG-5128 did not modify basal prolactin secretion, but alpha-1 adrenoceptor blockade by prazosin strongly enhanced prolactin plasma levels. These findings suggest that noradrenergic pathways in the central nervous system exert inhibitory tone on basal prolactin secretion, and that this effect seems to be mediated by alpha-1 adrenoceptors.
de Castro e Silva
E J
EJ
Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidad Federal da Bahia, Salvador, Brasil.
Antunes-Rodrigues
J
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D011217:Practolol / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011388:Prolactin / Q000097:blood* / Q000502:physiology; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D007004:Hypoglycemic Agents; D007093:Imidazoles; D011412:Propanolamines; D011941:Receptors, Adrenergic; C032368:midaglizole; C014898:IPS 339; D011388:Prolactin; D011217:Practolol; D011224:Prazosin