Haplotype-specific interactions of non-H-2-linked genetic factors controlling the mouse C4 and Slp protein levels.
The influence of non-H-2 linked genes on the plasma levels of the H-2 S-region encoded proteins C4, Slp, and factor B was tested in Recombinant Inbred (RI) strains. The A X B and B X A RI strains exhibit a continuous range of C4 and Slp levels from very high to very low which reach beyond the levels of their parental strains, C57BL/6J and A/J, indicating involvement of several trans-regulatory (non-H-2-linked) genes. Only limited variation in levels of factor B has been found. No linkage relationship could be established for the trans-regulatory genes, because more than one gene is involved. A complex interaction of H-2 haplotype, genetic background, sex, and possibly maternal effect in determining the C4 and Slp protein plasma levels has been observed. The H-2-dependent sex effect is evident, because males have higher C4 levels than females in RI strains with H-2b but not with H-2a haplotype. This sex effect is also background dependent, because it is present in the H-2b congenic strain on A background (A.BY) but not in C57BL/10 and C57BL/6 (both H-2b). Mice from RI strains with H-2b haplotype have in general higher C4 levels than mice with H-2a haplotype.
Bruisten
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Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam.
Skamene
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Demant
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D000818:Animals; D001798:Blood Proteins / Q000235:genetics*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006239:Haplotypes; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
D001798:Blood Proteins