title: [The role of cyclic nucleotides in reparative bone formation].
abstract: Distinct alterations in content of cyclic nucleotides were observed during treatment of 133 patients with fractures of long tubular bones. The following effects were found after initial increase in cAMP content: increase in tissue permeability, aseptic inflammation, inhibition of cell mitosis, acceleration of cell enzymes synthesis, of protein biosynthesis and of the rate of microcirculation in the traumatized region. Elevation of cGMP concentration led to initiation of bone marrow proliferation, to augmented formation of organic matrix and its mineralization. Monitoring of cyclic nucleotides concentration enabled to evaluate the reparative osteogenesis activity.
authors.forename: A A
authors.initials: AA
authors.lastname: Sveshnikov
authors.forename: N V
authors.initials: NV
authors.lastname: Ofitserova
authors.forename: S V
authors.initials: SV
authors.lastname: Ral'nikova
authors.forename: A P
authors.initials: AP
authors.lastname: Kuznetsov
mesh_terms: D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005360:Fibula / Q000293:injuries; D005592:Fracture Fixation; D005596:Fractures, Closed / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D013977:Tibia / Q000293:injuries; D014945:Wound Healing
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP
vernacular_title: Rol' tsiklicheskikh nukleotidov v reparativnom kosteobrazovanii.