Plasma cell malignancy in the acquired immune deficiency syndrome. Association with Epstein-Barr virus.
The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient.
Voelkerding
K V
KV
Department of Pathology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway.
Sandhaus
L M
LM
Kim
H C
HC
Wilson
J
J
Chittenden
T
T
Levine
A J
AJ
Raska
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000328:Adult; D004279:DNA, Viral / Q000235:genetics*; D015321:Gene Rearrangement; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007075:Immunoglobulin M / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000382:microbiology; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics* / Q000382:microbiology
D004279:DNA, Viral; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains