Pulmonary involvement in infectious mononucleosis: histopathologic features and detection of Epstein-Barr virus-related DNA sequences.
Symptomatic pulmonary parenchymal involvement is rare in infectious mononucleosis, and few pathologic descriptions of this lesion exist. We describe an unusual patient who presented with adenopathy and rapidly progressive interstitial lung disease. An open lung biopsy showed a predominantly interstitial infiltrate of mononuclear cells distributed along lymphatic routes. A patchy alveolar exudate was also seen. Biopsy of a paratracheal lymph node showed paracortical hyperplasia typical of infectious mononucleosis. The diagnosis was suspected only after thoracotomy and was established by appropriate serological studies for Epstein-Barr virus. Epstein-Barr virus genomic sequences were also detected within routinely processed lung and lymph node tissues using polymerase chain reaction technology. Infectious mononucleosis should be considered in the differential diagnosis of certain lymphoid lung lesions.
Myers
J L
JL
Division of Surgical Pathology, University of Alabama, Birmingham.
Peiper
S C
SC
Katzenstein
A L
AL
D000956:Antigens, Viral; D036022:Capsid Proteins; D015342:DNA Probes; D004279:DNA, Viral / Q000302:isolation & purification*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008205:Lymphangitis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D000956:Antigens, Viral; D036022:Capsid Proteins; D015342:DNA Probes; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D004259:DNA-Directed DNA Polymerase