Platelet prostaglandin E1 hyposensitivity in schizophrenia: reduction of prostaglandin E1- or forskolin-stimulated cyclic AMP response in platelets.
Cyclic 3',5'-adenosine monophosphate (cAMP) formation via prostaglandin E1 (PGE1)-or forskolin-stimulation were determined in washed intact platelets from 32 schizophrenic patients and 30 normal controls. Regarding basal cAMP levels in the platelets, there were no differences between schizophrenic patients and normal controls. Both PGE1-and forskolin-stimulated cAMP response reduced in platelets from schizophrenics compared with normal controls. These results suggested that platelets in schizophrenics were impaired not only in the adenylate cyclase unit per se but also extensively in the cAMP generating system coupled to a PGE1 receptor.
Ofuji
M
M
Department of Pharmacology, Gifu University School of Medicine, Japan.
Kaiya
H
H
Nozaki
M
M
Tsurumi
K
K
D000262:Adenylyl Cyclases / Q000097:blood; D000328:Adult; D000527:Alprostadil / Q000032:analysis* / Q000097:blood / Q000494:pharmacology* / Q000502:physiology; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000032:analysis* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000201:enzymology / Q000503:physiopathology*
D005576:Colforsin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil