[Dynorphin and atriopeptin may be involved in the depressor mechanism of clonidine].
Intravenous injection (iv) of clonidine significantly induced depressor and bradycardiac responses in rats. These responses were found to be blocked by iv alpha-adrenoreceptor blocker phentolamine, intraperitoneous injection (ip) of naloxone (10mg/kg) or iv antidynorphin-IgG(80 microliters). Furthermore, clonidine (iv) induced a significant increase of urine volume, which was also partly blocked by naloxone (10mg/kg). A dramatic increase of rat plasma immunoreactive atriopeptin induced by clonidine (iv) was partly antagonised by pretreatment with naloxone (4mg/kg) or phentolamine (10mg/kg). These results show that dynorphin and atriopeptin may be involved in the depressor mechanism of clonidine.
Yin
L Y
LY
Gao
X M
XM
Xie
C W
CW
Tang
J A
JA
D000818:Animals; D000959:Antihypertensive Agents; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D004232:Diuretics; D004399:Dynorphins / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D004232:Diuretics; D004399:Dynorphins; D009320:Atrial Natriuretic Factor; D003000:Clonidine