title: Close linkage of MEN2A with RBP3 locus in Japanese kindreds.
abstract: The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromosome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.
authors.affiliation: Second Department of Surgery, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Takai
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: K
authors.initials: K
authors.lastname: Motomura
authors.forename: M
authors.initials: M
authors.lastname: Okazaki
authors.forename: I
authors.initials: I
authors.lastname: Nishisho
authors.forename: H
authors.initials: H
authors.lastname: Tateishi
authors.forename: A
authors.initials: A
authors.lastname: Miyauchi
authors.forename: T
authors.initials: T
authors.lastname: Honjo
authors.forename: A J
authors.initials: AJ
authors.lastname: Pakstis
mesh_terms: D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D008126:Lod Score; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D010375:Pedigree; D012177:Retinol-Binding Proteins / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D012177:Retinol-Binding Proteins