title: Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization.
abstract: The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-microns) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.
authors.affiliation: Department of Geriatric Medicine, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Adem
authors.forename: S S
authors.initials: SS
authors.lastname: Jossan
authors.forename: R
authors.initials: R
authors.lastname: d'Argy
authors.forename: P G
authors.initials: PG
authors.lastname: Gillberg
authors.forename: A
authors.initials: A
authors.lastname: Nordberg
authors.forename: B
authors.initials: B
authors.lastname: Winblad
authors.forename: V
authors.initials: V
authors.lastname: Sara
mesh_terms: D000368:Aged; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017451:Receptors, Somatomedin
chemical_list: D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I