Prophylactic activity against Sendai virus infection and macrophage activation with lipophilic derivatives of N-acetylglucosaminylmuramyl tri- or tetrapeptides.
The efficacy of N-acetylglucosaminyl-beta (1----4)-N-acetylmuramyl tri- or tetrapeptides (GM) and the lipophilic derivatives for host augmentation against Sendai virus infection and for macrophage activation in vitro was examined. The anti-infectious activities of GM derivatives were shown to increase with the chain length of the fatty acid combined with the diaminopimelyl group. When the macrophages were activated with 1 U ml-1 murine interferon gamma (IFN-gamma) and 0.001 microgram ml-1 GM derivatives, the cytocidal ability of macrophages depended on the length of the side chain, and exhibited a positive relationship with the anti-infectious activity of GM derivatives against Sendai virus infection. These results indicated that the increment of lipophilicity of GM derivatives would play an important role in the anti-infectious activity and macrophage activation in vitro.
Iida
J
J
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Saiki
I
I
Ishihara
C
C
Azuma
I
I
D000276:Adjuvants, Immunologic / Q000276:immunology; D000818:Animals; D006020:Glycopeptides / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007371:Interferon-gamma / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009112:Muramic Acids / Q000276:immunology*; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000517:prevention & control*; D010455:Peptides; D013400:Sugar Acids / Q000276:immunology*
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D009112:Muramic Acids; D010455:Peptides; D013400:Sugar Acids; D007371:Interferon-gamma