title: [Ion conductance channels of bilayer from sarcoma-45 phospholipids].
abstract: Properties of black bilayer membranes formed from sarcoma-45 phospholipids differed from those of normal cell phospholipids bilayers. Two types of Ca2+-channels were discovered: those multiple to 35 pA and those multiple to 90 pA. The study of bilayers from phospholipids of nuclei, mitochondria, microsomal fractions showed that Ca2+-channels were localized in the microsomal fraction of transformed cells. The relationship between DB18C6 diacetylderivatives membrane activity and their effect to growth of sarcoma-45 in vivo was discovered: the Ca2+-channel blocker diacetyl-DB18C6 inhibited the transformed cells growth.
authors.forename: U Z
authors.initials: UZ
authors.lastname: Mirkhodzhaev
authors.forename: V A
authors.initials: VA
authors.lastname: Boldyrev
authors.forename: A K
authors.initials: AK
authors.lastname: Tashmukhamedova
authors.forename: V P
authors.initials: VP
authors.lastname: Tatarskiĭ
authors.forename: I N
authors.initials: IN
authors.lastname: Dimant
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D043844:Crown Ethers; D004988:Ethers, Cyclic / Q000494:pharmacology; D008051:Lipid Bilayers; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D043844:Crown Ethers; D004988:Ethers, Cyclic; D008051:Lipid Bilayers; D010743:Phospholipids; C002564:dibenzo-18-crown-6
vernacular_title: Ionnye kanaly provodimosti bisloev iz fosfolipidov sarkomy-45.