Late inhibitory postsynaptic potentials in rat prefrontal cortex may be mediated by GABAB receptors.
The GABAB antagonist phaclofen blocked the postsynaptic hyperpolarization induced by the GABAB agonist baclofen during intracellular recordings in rat cortical cells. This effect appears to be selective since responses to GABAA agonists (muscimol, THIP), GABA, 5-HT and L-glutamate were unaffected. Phaclofen also blocked synaptically evoked late inhibitory postsynaptic potentials (late IPSP). These results suggest that the late IPSPs in cortical neurons are mediated by GABA acting on GABAB receptors.
Karlsson
G
G
Biology Research Department, Ciba-Geigy Ltd, Basle, Switzerland.
Olpe
H R
HR
D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives / Q000494:pharmacology; D004553:Electric Conductivity; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005625:Frontal Lobe / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D007555:Isoxazoles; D011963:Receptors, GABA-A; C052329:phaclofen; D009118:Muscimol; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; C015542:gaboxadol