Lymphocytosis of large granular lymphocytes associated with anemia and neutropenia: proof of monoclonality of the LGL-population, but benign clinical course.
A 37-year-old man with severe transfusion-requiring anemia and neutropenia associated with lymphocytosis of large granular lymphocytes (LGLs) has been followed over a period of 3.5 years. Detailed phenotyping of the LGL has been performed, revealing a phenotype of CD3+, CD8+, CD16+, HLA-DR+, and Leu-7+. Southern-blot analysis of the T-cell receptor beta-chain locus detected a gene rearrangement, thus providing proof of monoclonality of the peripheral blood LGLs.
Serke
S
S
Abteilung für Innere Medizin, Universitätsklinikum Rudolf Virchow der Freien Universität Berlin, Standort Charlottenburg.
Neubauer
A
A
Huhn
D
D
D000328:Adult; D000380:Agranulocytosis / Q000473:pathology*; D000740:Anemia / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008218:Lymphocytosis / Q000473:pathology*; D008297:Male; D009503:Neutropenia / Q000473:pathology*; D013601:T-Lymphocytes / Q000145:classification* / Q000473:pathology