title: Involvement of cysteine, serotonin and their analogues in peroxidase-oxidase reactions.
abstract: Myeloperoxidase-oxidase reactions with close to physiological concentrations of thiols and phenols were studied. Cysteine was shown to be a myeloperoxidase-oxidase substrate when catalytic amounts of serotonin were added as cosubstrate. Penicillamine could be substituted for cysteine and acetaminophen could be substituted for serotonin. The properties of these peroxidase-oxidase reactions, e.g. the dependence on substrate and myeloperoxidase concentration, reduced oxygen species, metal ions and pH, were studied. Also, eosinophil, lacto- and horseradish peroxidase could catalyse these reactions.
authors.affiliation: Research and Development Department, Södertälje, Sweden.
authors.forename: B E
authors.initials: BE
authors.lastname: Svensson
mesh_terms: D000818:Animals; D003545:Cysteine / Q000378:metabolism; D006801:Humans; D010088:Oxidoreductases / Q000378:metabolism*; D010101:Oxygen Consumption; D009195:Peroxidase / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D010636:Phenols; D013438:Sulfhydryl Compounds; D012701:Serotonin; D010088:Oxidoreductases; D010544:Peroxidases; D009195:Peroxidase; D003545:Cysteine