Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients.
Forty patients with chronic urticaria were treated with terfenadine or astemizole in a randomized double-blind study. The intensity of the symptoms was quantified and documented daily by the patients. Both antihistamines had a clear effect on the intensity of the pruritus and the severity of the wheals. Neither astemizole nor terfenatine produced any sedative side effects.
Paul
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Zentrum für Dermatologie und Andrologie-Hautklinik-am Klinikum, Justus-Liebig-Universität Giessen, W Germany.
Bödeker
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RH
D016589:Astemizole; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D011897:Random Allocation; D013223:Statistics as Topic; D016593:Terfenadine; D014581:Urticaria / Q000188:drug therapy* / Q000209:etiology
D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D016589:Astemizole