[Isolation and in vitro and in vivo characteristics of a clone of a wild Aujeszky disease virus resistant to bromovinyldeoxyuridine].
The antiviral activity of bromovinyldeoxyuridine has been studied on the wild type of pseudorabies virus. A heterogenicity of viral populations has been observed. A resistant clone presented special characteristics both in vitro (large syncytia, round cells) and in vivo (reduced pathogenicity and immunogenic power).
Bijlenga
G
G
Ecole Nationale Vétérinaire de Lyon, Services de maladies contagieuses, France.
Joubert
L
L
De Clercq
E
E
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000494:pharmacology / Q000031:analogs & derivatives; D002415:Cats; D002417:Cattle; D004285:Dogs; D004352:Drug Resistance, Microbial; D005260:Female; D011558:Herpesvirus 1, Suid / Q000032:analysis / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D051379:Mice; D014776:Virus Cultivation
D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine
Isolement et caractères in vitro et in vivo d'un clone de virus sauvage de la maladie d'Aujeszky résistant à la bromovinyldésoxyuridine.