title: Effect of dietary sodium on the Na-K ATPase inhibitor in patients with essential hypertension.
abstract: To study the circulating humoral factor modifying transmembrane sodium transport, plasma was obtained from 12 patients with essential hypertension (EH) fed a high sodium diet (NaCl 15 to 17 g/d) for seven days and thereafter a low sodium diet (NaCl 2 to 3 g/d) for seven days. Ouabain-sensitive 86Rb+ influx into the red blood cells (RBC) obtained from a healthy subject, and incubated with the plasma obtained during the high sodium diet was significantly lower than that incubated with the plasma obtained during the low sodium diet (3.74 +/- 0.26 v 3.97 +/- 0.30 nmol/10(8) cells, P less than .05). The changes in mean blood pressure from the high to low sodium diet showed a significant positive correlation with the changes in the ouabain-sensitive Rb influx into RBC in the plasma from the high to low sodium diet. These results suggest that a humoral factor modifying the sodium pump might be altered by sodium balance in EH, especially in salt-sensitive hypertension.
authors.affiliation: Department of Medicine, National Cardiovascular Center, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ashida
authors.forename: M
authors.initials: M
authors.lastname: Kuramochi
authors.forename: S
authors.initials: S
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Yoshimi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: G
authors.initials: G
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Imanishi
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
mesh_terms: D000450:Aldosterone / Q000097:blood; D001692:Biological Transport / Q000187:drug effects; D001798:Blood Proteins; D001835:Body Weight / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011506:Proteins; D012083:Renin / Q000097:blood; D012414:Rubidium Radioisotopes; D012982:Sodium, Dietary / Q000493:pharmacokinetics / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D000097795:ATPase Inhibitory Protein
chemical_list: D000450:Aldosterone; D001798:Blood Proteins; D011506:Proteins; D012083:Renin; D012414:Rubidium Radioisotopes; D012982:Sodium, Dietary; D000254:Sodium-Potassium-Exchanging ATPase; D000097795:ATPase Inhibitory Protein