Tubuloreticular inclusions in equine connective tissue neoplasms.
Abnormal irregularly branched and anastomosing tubules within cisternae of endoplasmic reticulum were observed by transmission electron microscopy in tumour cells comprising connective tissue neoplasms (sarcoids) from three horses and a mule. These tubuloreticular inclusions were also observed in cultured tumour cells from one of these horses examined, but were not detected in fibroblasts (fibrocytes), epidermis, or vascular endothelial cells in skin biopsy specimens from five clinically healthy horses, nor in one additional equine connective tissue neoplasm.
Madewell
B R
BR
Department of Veterinary Surgery, School of Veterinary Medicine, University of California, Davis 95616.
Munn
R J
RJ
D000818:Animals; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D005354:Fibrosarcoma / Q000648:ultrastructure / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*