title: Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids. III.
abstract: Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated.
authors.forename: T
authors.initials: T
authors.lastname: Nikaido
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: U
authors.initials: U
authors.lastname: Sankawa
authors.forename: F
authors.initials: F
authors.lastname: Delle Monache
authors.forename: B
authors.initials: B
authors.lastname: Botta
authors.forename: T
authors.initials: T
authors.lastname: Tomimori
authors.forename: Y
authors.initials: Y
authors.lastname: Miyaichi
authors.forename: Y
authors.initials: Y
authors.lastname: Shirataki
authors.forename: I
authors.initials: I
authors.lastname: Yokoe
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D015105:3',5'-Cyclic-AMP Phosphodiesterases