Perinatal lead exposure impairs opioid but not non-opioid stress-induced antinociception in developing rats.
1. The development of opioid systems has been shown to be sensitive to perinatal exposure to lead. We have studied the effects of such exposure on opioid and non-opioid mediated stress-induced antinociception in developing rats. 2. Lead was administered in the maternal drinking water from conception to postnatal day 14 at 300 and 1000 p.p.m. Twenty and 25 day old rats were subjected to swimming stress and antinociception measured using the tail immersion test. 3. A 3 min swim-stress induced an opioid-mediated antinociceptive response in 20 day old rats which was attenuated by 300 p.p.m. lead and by 1000 p.p.m. lead treatment in a dose-related manner. A 10 min swim-stress induced a non-opioid mediated antinociceptive response in 25 day old rats which was not antagonised by 300 or 1000 p.p.m. lead. 4. Naloxone antagonised the residual antinociception observed in 20 day old animals treated with 300 p.p.m. lead and had no effect on antinociception in control or lead-treated 25 day old rats. 5. Using a lead exposure model considered to represent subclinical lead toxicity in man, it was shown that perinatal lead exposure disrupts opioid but not non-opioid mediated stress antinociception.
Jackson
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Department of Biochemistry, University of Surrey, Guildford.
Kitchen
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D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005260:Female; D007855:Lead Poisoning / Q000503:physiopathology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013550:Swimming
D011957:Receptors, Opioid; D009270:Naloxone