Anti-shock effects of synthetic effective compositions of fructus aurantii immaturus. Experimental study and clinical observation.
Satisfactory results have been obtained in treating infective shock with injection of natural Fructus Aurantii immaturus (nat-FAI). The results of animal experiments and clinical observations on the anti-shock effects of the synthetic effective compositions of Fructus Aurantii immaturus (syn-FAI) are reported. The cardiac output increased from 0.53 to 0.87 L/min (P less than 0.01), and the cardiac index increased from 0.99 to 1.63 L/m2/min (P less than 0.01) in the endotoxic shock dogs after the treatment with syn-FAI. At the same time the blood stream in bulbar conjunctiva became accelerated and the dilated microvessels began to get smaller in most dogs. Of fifty children with infective shock treated with syn-FAI, forty-eight showed curative effects, with a total effective rate of 96%. The anti-shock effective compositions in FAI have been proved to be synephrine and N-methyltyrosamine. Moreover, syn-FAI has shown a more stable property, less side-effects and better clinical results than nat-FAI.
Zhao
X W
XW
Li
J X
JX
Zhu
Z R
ZR
Sun
D Q
DQ
Liu
S C
SC
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000818:Animals; D002648:Child; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006801:Humans; D012772:Shock, Septic / Q000188:drug therapy*; D013578:Synephrine / Q000627:therapeutic use*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000316:Adrenergic alpha-Agonists; D004365:Drugs, Chinese Herbal; C036244:methyl-4-tyramine; D013578:Synephrine; D014439:Tyramine