[Effect of itraconazole on the process of mycelial transformation of Candida albicans cells in human serum].
Results of in vitro studies on the influence of itraconazole on mycelial transformation of 88 Candida albicans strains are presented. The drug influenced a number of cells capable to produce filaments. The number of those cells diminished gradually together with the increase of the drug concentration. The range of TI100 values was between 0.02 and 18.0 micrograms ml of medium. Mycelial transformation phenomenon can be applied for preliminary and rapid evaluation of Candida albicans strains sensitivity to itraconazole.
Gwiezdziński
Z
Z
Urbanowski
S
S
Nierebińska
E
E
D000935:Antifungal Agents; D001769:Blood; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects*; D002452:Cell Count / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D003470:Culture Media; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000935:Antifungal Agents; D003470:Culture Media; D017964:Itraconazole; D007654:Ketoconazole
Wpływ itrakonazolu na proces mycelialnej transformacji komórek Candida albicans w surowicy ludzkiej.