title: In vitro comparison of the neuromuscular antinicotinic and intestinal antimuscarinic effects of different nondepolarizing muscle relaxants.
abstract: The postsynaptic antimuscarinic properties of different nondepolarizing muscle relaxants were compared with their postsynaptic antinicotinic effect. d-Tubocurarine, pipecuronium and vecuronium were the most selective antagonists on postsynaptic nicotinic receptors. Gallamine, diadonium and Duador (RGH-4201) had relatively greater effect on postsynaptic muscarinic receptors. Therefore, much less side effect is expected to occur when pipecuronium, d-tubocurarine or vecuronium are used.
authors.affiliation: Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
authors.forename: A
authors.initials: A
authors.lastname: Töröcsik
authors.forename: I A
authors.initials: IA
authors.lastname: Chaudhry
authors.lastname: Bíro K
authors.forename: H
authors.initials: H
authors.lastname: Nagashima
authors.forename: M
authors.initials: M
authors.lastname: Kinjo
authors.forename: D
authors.initials: D
authors.lastname: Duncalf
authors.forename: R
authors.initials: R
authors.lastname: Nagashima
authors.forename: F F
authors.initials: FF
authors.lastname: Foldes
authors.forename: P L
authors.initials: PL
authors.lastname: Goldiner
authors.forename: E S
authors.initials: ES
authors.lastname: Vizi
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010197:Pancuronium / Q000494:pharmacology; D010276:Parasympatholytics; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D010095:Oxotremorine; D010197:Pancuronium