Syndrome of resistance to thyroid hormone in an infant with congenital cytomegalovirus infection.
We describe an infant with congenital cytomegalovirus infection who developed the syndrome of resistance to thyroid hormone at three weeks of age, presenting with elevated thyroxine levels and non-suppressible thyroid-hormone-stimulating hormone secretions without any features of thyrotoxicosis. The resistance was present at the peripheral and pituitary levels and resolved spontaneously by 18 months of age. Cytomegalovirus infection was confirmed by the positive urine culture of this virus. This case demonstrates for the first time a possible association of thyroid hormone resistance with congenital cytomegalovirus infection.
Hirano
T
T
Jogamoto
M
M
Chin
I
I
D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital; D006801:Humans; D008297:Male; D013577:Syndrome; D013959:Thyroid Diseases / Q000150:complications*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood
D013963:Thyroid Hormones; D013972:Thyrotropin