title: Influence of Ly146032 on chemotaxis, chemiluminescence of PMN and lymphocyte transformation in vitro.
abstract: The influence of Ly146032, a new acidic lipopeptide, on chemotaxis, luminol-dependent chemiluminescence of human polymorphonuclear leukocytes (PMN) and phythemagglutinin induced lymphocyte transformation of murine cells was investigated. At therapeutic range there was no remarkable effect on the parameters tested. Incubation with more than 20 mg/l Ly146032 was followed by depression of chemiluminescence, whilst transformation of maximally PHA stimulated lymphocytes was suppressed by more than 32 mg/l Ly146032.
authors.affiliation: Abteilung Med. Mikrobiologie, Klinikum der Christian Albrechts-Universität Kiel, FR Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schubert
authors.forename: U
authors.initials: U
authors.lastname: Ullmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D017576:Daptomycin; D006801:Humans; D008163:Luminescent Measurements; D008213:Lymphocyte Activation / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin