The role of excitatory amino acids in synaptic transmission in the hippocampus.
We have highlighted some aspects of the action of excitatory amino acid transmission in the hippocampus. Fast epsps can be blocked by CNQX to reveal a component of synaptic transmission which is mediated by NMDA receptors. Extracellular recordings of ionic activities show that NMDA and non-NMDA ionophores are permeable to the major monovalent cations, while NMDA ionophores also appear to be permeable to Ca2+. Interactions of agonists applied by iontophoresis may be correlates of phenomena such as LTP, which can be evoked by appropriate synaptic stimulation.
Lambert
J D
JD
Institute of Physiology, Universitetsparken, University of Aarhus, Denmark.
Jones
R S
RS
Andreasen
M
M
Jensen
M S
MS
Heinemann
U
U
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D007477:Ions; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D000596:Amino Acids; D007477:Ions; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface