[Endogenous digoxin-like factor: serum concentration and interrelations with the electrolyte picture in normal subjects].
Endogenous Digitalis-Like Factor (DLF) is a putative hypothalamic Na+,K+-ATPase inhibitor that mediates natriuresis in response to intravascular volume expansion or sodium loading. The precise structure of this substance remains unknown; however, it cross-reacts with antibody to digoxin. Using a radioimmunoassay, we measured DLF concentrations in 26 normal subjects: mean value of this factor was 0.512 ng digoxin-equivalents/ml +/- 0.038 SEM; DLF correlated significantly with serum sodium levels (r = 0.59 - p less than 0.01) and daily urinary sodium excretion (r = 0.48 - p less than 0.05). Our results confirm that endogenous digitalis-like factor has a physiological role as regulator of natriuresis, in response to plasma sodium concentrations.
Andronico
G
G
Mangano
M T
MT
Carone
M B
MB
Cerasola
G
G
D000328:Adult; D001798:Blood Proteins / Q000032:analysis / Q000502:physiology*; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012503:Saponins; D012964:Sodium / Q000097:blood* / Q000652:urine*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase
Fattore simil-digossinico endogeno: concentrazione sierica ed interrelazioni con il quadro elettrolitico nei soggetti normali.