title: [PTH-like tumor peptide and malignant hypercalcemia].
abstract: Certain patients with malignant hypercalcemia display enhanced bone resorption and changes in renal tubular handling of calcium and phosphate similar to those encountered in primary hyperparathyroidism. A tumoral protein probably responsible for this syndrome has recently been described. Produced by a gene other than that of parathyroid hormone, it shows an aminoterminal homology with the physiological hormone. In some respect both proteins exert similar effects. This parathyroid hormone-analogue may also be involved in physiological regulatory functions.
authors.affiliation: Département de médecine, Hôpital cantonal universitaire, Genève.
authors.forename: R
authors.initials: R
authors.lastname: Rizzoli
authors.forename: J P
authors.initials: JP
authors.lastname: Bonjour
mesh_terms: D004999:Amifostine / Q000494:pharmacology; D001862:Bone Resorption; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000378:metabolism*; D044162:Parathyroid Hormone-Related Protein
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D004999:Amifostine; D002118:Calcium
vernacular_title: Peptide tumoral "PTH-like" et hypercalcémie maligne.