title: Oral hairy leukoplakia: observations in 95 cases and review of the literature.
abstract: Oral hairy leukoplakia (HL) was observed in 25.4% of 373 HIV-seropositive patients (n = 95). 87 were men of an average age of 37.1 yr, 8 were women (30.3 yr). 71.6% of the patients were male homosexuals. At initial diagnosis of HL the majority of cases was classified as CDC IVc1 (45.3%) and CDC II (22.1%). Average CD4/CD8 ratio (n = 19) was 0.24 with a range of 0.04-1.0. Thirty biopsies of HL revealed some of the histologic features thought to be characteristic. In only 20 of 30 biopsies EB-virus-specific-capsid antigen was detected. The problems of clinical and histological diagnosis of HL are discussed. Further strict criteria are necessary in order to define HL more distinctly.
authors.affiliation: Abteilung für zahnärztliche Chirurgie/Oralchirurgie-Nord-Freie Universität Berlin, West Germany.
authors.forename: P A
authors.initials: PA
authors.lastname: Reichart
authors.forename: A
authors.initials: A
authors.lastname: Langford
authors.forename: H R
authors.initials: HR
authors.lastname: Gelderblom
authors.forename: H D
authors.initials: HD
authors.lastname: Pohle
authors.forename: J
authors.initials: J
authors.lastname: Becker
authors.forename: H
authors.initials: H
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006679:HIV Seropositivity; D004854:Herpesvirus 4, Human; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D014062:Tongue Neoplasms / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*