title: Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.
abstract: The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na+,K+-ATPase beta-subunit. A partial structure of the beta 1-gene was determined, the coding part of which was completely homologous to cDNA of the Na+,K+-ATPase beta I-subunit from HeLa cells. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (beta psi) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the beta I-subunit cDNA from HeLa cells is about 88%.
authors.affiliation: Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
authors.lastname: Ushkaryov YuA
authors.forename: G S
authors.initials: GS
authors.lastname: Monastyrskaya
authors.forename: N E
authors.initials: NE
authors.lastname: Broude
authors.forename: N N
authors.initials: NN
authors.lastname: Nikiforova
authors.forename: D A
authors.initials: DA
authors.lastname: Bessarab
authors.lastname: Orlova MYu
authors.forename: K E
authors.initials: KE
authors.lastname: Petrukhin
authors.forename: N N
authors.initials: NN
authors.lastname: Modyanov
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
mesh_terms: D000818:Animals; D001483:Base Sequence; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D011544:Pseudogenes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D013552:Swine
chemical_list: D008565:Membrane Proteins; D000254:Sodium-Potassium-Exchanging ATPase