Thrombin-antithrombin III complexes in the prediction of deep vein thrombosis following total hip replacement.
In 196 consecutive patients who underwent elective total hip surgery we investigated the diagnostic accuracy of the thrombin-antithrombin III complex immunoassay, as assessed on the first, fourth and tenth postoperative day, for the development of deep vein thrombosis (DVT). Patients received either LMW-heparinoid (n = 97) or placebo (n = 99) and underwent contrast venography on the tenth postoperative day. Thrombin-antithrombin III (T-AT) plasma levels were raised in all patients on the first postoperative day and gradually decreased during the study period. T-AT plasma levels were significantly higher in patients developing DVT when compared to patients without DVT and remained so until day 10. This difference was apparent both in the LMW-heparinoid group as well as in the placebo-treated patients. ROC-curve analysis revealed no satisfactory discriminative power for the diagnosis of developing DVT at any of the studied cut-off values for T-AT. We conclude that the postoperative determination of T-AT complex plasma concentrations in hip surgery patients has no clinical utility in the prediction of postoperative DVT.
Hoek
J A
JA
Centre for Hemostasis, Thrombosis and Atherosclerosis Research, Academic Medical Center, Amsterdam, The Netherlands.
Nurmohamed
M T
MT
ten Cate
J W
JW
Büller
H R
HR
Knipscheer
H C
HC
Hamelynck
K J
KJ
Marti
R K
RK
Sturk
A
A
D000990:Antithrombin III / Q000032:analysis*; D004796:Clinical Enzyme Tests; D004311:Double-Blind Method; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D010447:Peptide Hydrolases / Q000032:analysis*; D010690:Phlebography; D016032:Randomized Controlled Trials as Topic; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000517:prevention & control
D006495:Heparin, Low-Molecular-Weight; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases