Onset and duration of clinical relaxation of atracurium and vecuronium in patients on chronic nifedipine therapy.
The onset and duration of clinical relaxation of atracurium and vecuronium were studied in patients on chronic nifedipine therapy and compared to similar groups of patients not on such a therapy. Neuromuscular block was monitored by recording the integrated electromyogram of the hypothenar muscles (using a 'Datex Relaxograph') following stimulation of the ulnar nerve with a train-of-four stimulation. Neither the time to onset of maximum block (3.0-3.4 min) nor the duration of clinical relaxation (36-40 min) differed significantly between the groups indicating no significant interaction in humans between atracurium and vecuronium and chronic nifedipine therapy.
Bell
P F
PF
Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast, United Kingdom.
Mirakhur
R K
RK
Elliott
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001279:Atracurium / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D009543:Nifedipine / Q000627:therapeutic use*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000494:pharmacology*
D001279:Atracurium; D014673:Vecuronium Bromide; D009543:Nifedipine