Cytochemistry of dipeptidylaminopeptidase IV in T lymphoblastic leukaemia-lymphoma.
The cytochemical distribution of dipeptidylaminopeptidase IV (DAP IV) was studied in 5 cases of T lymphoblastic leukaemic lymphoma and 12 cases of acute T lymphoblastic leukaemia, in order to ascertain differences between the enzyme positivity patterns of T cells at different stages of differentiation. Early thymic phenotype cases were almost completely negative; those of intermediate and mature thymic phenotype showed positivity in various percentages of blasts: either a single coarse granule or many coarse and small granules were detected. In mature phenotype cells a particularly intense DAP IV reaction was observed. In conclusion, our findings suggest that DAP IV reaction could be a useful tool for the cytochemical characterization of T acute leukaemia subtypes.
Invernizzi
R
R
Department of Internal Medicine, University of Pavia, Italy.
Perugini
O
O
De Fazio
P
P
Bonetti
F
F
Nespoli
B L
BL
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000032:analysis*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4