[Interrelation of degradation processes of purine nucleotides and their biosynthetic transformation in the blood cells of patients with acute leukemia].
It has been shown that the leukemic process shifts the balance of individual enzymatic steps of the purine nucleotide degradation and biosynthesis. In acute lymphoblastic leukosis (ALL) and acute myeloblastic leukosis (AML) the rate of purine degradation, as estimated by the ADA enzyme activity (ES 3.5.4.4.) and PNP (EC 2.4.2.1), exceeds considerably that of their enzymes AMP-DA (EC 3.5.4.6.) and IMP-DH (EC 1.2.1.14.) biosynthesis. The data obtained suggest the existence of differences in the enzymatic program of purine metabolism in the malignant transformation of hematopoietic tissue and in other tumours.
Filanovskaia
L I
LI
Togo
A V
AV
Blinov
M N
MN
D000659:AMP Deaminase / Q000097:blood; D000243:Adenosine Deaminase / Q000097:blood; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007168:IMP Dehydrogenase / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000628:therapy; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000628:therapy; D011685:Purine Nucleotides / Q000097:blood*; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood
D011685:Purine Nucleotides; D007168:IMP Dehydrogenase; D011683:Purine-Nucleoside Phosphorylase; D000243:Adenosine Deaminase; D000659:AMP Deaminase
Vzaimosviaz' protsessov degradatsii purinovykh nukleotidov i ikh biosinteticheskikh prevrashcheniĭ v kletkakh krovi bol'nykh ostrym leĭkozom.