title: Participation of opiate receptors located in the nucleus tractus solitarii in the hypotension induced by alpha-methyldopa.
abstract: The local administration of the opiate receptor antagonist, naltrexone, into the nucleus tractus solitarii (NTS) inhibited the hypotension induced by systemically injected alpha-methyldopa in conscious rats. In addition, the local injection into the NTS of a beta-endorphin antiserum but not of antisera against [Met5]enkephalin and dynorphin A(1-13) prevented the alpha-methyldopa-induced hypotension. These results suggest a role of opiate receptors in the NTS, or in a closely located medullary site, in the centrally mediated hypotension induced by alpha-methyldopa.
authors.affiliation: Rudolf Magnus Institute, Medical Faculty, State University of Utrecht, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Van Giersbergen
authors.forename: P
authors.initials: P
authors.lastname: Roording
authors.forename: H
authors.initials: H
authors.lastname: de Lang
authors.forename: W
authors.initials: W
authors.lastname: de Jong
mesh_terms: D000818:Animals; D004723:Endorphins / Q000276:immunology / Q000502:physiology*; D007022:Hypotension / Q000139:chemically induced / Q000378:metabolism*; D007106:Immune Sera / Q000494:pharmacology; D008526:Medulla Oblongata / Q000378:metabolism* / Q000503:physiopathology; D008750:Methyldopa / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*
chemical_list: D004723:Endorphins; D007106:Immune Sera; D011957:Receptors, Opioid; D008750:Methyldopa; D009271:Naltrexone