Polymerase chain reaction for detection of dissemination in gastric lymphoma.
The polymerase chain reaction (PCR) was used to detect malignant lymphoma cells with the bcl-2 gene rearrangement in the peritoneal washings and bone marrow of a patient with an apparently localised gastric lymphoma. After four courses of cytotoxic drug treatment the cells could no longer be detected in either site. PCR is a useful addition to the staging investigations of non-Hodgkin lymphoma and can also be used to monitor response to treatment.
Cunningham
D
D
Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, London.
Hickish
T
T
Rosin
R D
RD
Sauven
P
P
Baron
J H
JH
Farrell
P J
PJ
Isaacson
P
P
D001402:B-Lymphocytes; D001856:Bone Marrow Examination; D002874:Chromosome Mapping; D004273:DNA, Neoplasm / Q000032:analysis; D004259:DNA-Directed DNA Polymerase; D004341:Drug Evaluation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015345:Oligonucleotide Probes; D010533:Peritoneal Lavage; D011518:Proto-Oncogene Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D015345:Oligonucleotide Probes; D011518:Proto-Oncogene Proteins; D004259:DNA-Directed DNA Polymerase