Paraneoplastic subacute cerebellar degeneration in Hodgkin's disease. Report of three cases and review of the literature.
12 cases of paraneoplastic cerebellar degeneration with Hodgkin's disease have so far been reported. Three additional patients (Stage II-IA/IIA/IIIB) are presented. Although CT and MR-imaging (MRI) revealed a marked cortical atrophy of the cerebellum, there was no evidence of direct brain involvement. After irradiation and chemotherapy all patients showed a complete remission. There was no evidence of primary disease after an observation period of 3/2/5 years. Cerebellar symptoms also showed a partial remission. As compared to the literature, our treatment appears to be more favorable, probably due to the fact, that therapy was more aggressive than usual.
Schlake
H P
HP
Department of Neurology, University Hospital Münster, FRG.
Husstedt
I W
IW
Grotemeyer
K H
KH
Pötter
R
R
D000328:Adult; D001284:Atrophy; D002526:Cerebellar Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology*