[Effect of benzodiazepines on enzyme-metabolizing drugs. III. Activity of microsomal monooxygenases in the rat liver exposed to chlordiazepoxide and elevated environmental temperature].
It has been stated that elevation of environment temperature to 28 degrees C or 35 degrees C modifies effects of chlordiazepoxide on activities of rat liver microsomal enzymic systems involved in metabolism of xenobiotics: amidopyrine, aniline and 4-nitroanisole++.
Pachecka
J
J
Wegiełek
J
J
Kobylińska
K
K
Bicz
W
W
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006358:Hot Temperature; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism*; D051381:Rats
D003574:Cytochrome c Group; D002707:Chlordiazepoxide; C026048:4-nitroanisole O-demethylase; D010088:Oxidoreductases; D010090:Oxidoreductases, O-Demethylating; D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase
Działanie benzodiazepin na enzymy metabolizujace leki. III. Aktywność mikrosomalnych monooksygenaz watroby szczura w nastepstwie działania chlordiazepoksydu i podwyzszonej temperatury otoczenia.