title: [Effect of several m-cholinoblockaders on the functioning of sodium potential-dependent channels of neuroblastoma cells].
abstract: Effects of two central antimuscarinic drugs, namely N-methyl-4-piperidinol benzylate and tropine phenylcyclopentylglycolate on Na currents in internally dialyzed mouse neuroblastoma cells were studied using the suction-pipette voltage-clamp technique. Like amine local anesthetics, the both compounds produce two phenomenologically different types of sodium current inhibition: a steady block without conditioning and a cumulative (use-dependent) block which develops during repetitive membrane pulsing. The ability of these m-cholinoblockers to modulate voltage-dependent ionic permeability of the neuronal membranes is supposed to be one of possible components in the mechanism of their both main and accessory (non-synaptic) effects.
authors.forename: A N
authors.initials: AN
authors.lastname: Zubov
authors.forename: I I
authors.initials: II
authors.lastname: Grishchenko
authors.forename: E D
authors.initials: ED
authors.lastname: Nosyreva
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D010276:Parasympatholytics; D015222:Sodium Channels
vernacular_title: Vliianie nekotorykh m-kholinoblokatorov na funktsionirovanie natrievykh potentsialzavisimykh kanalov kletok neĭroblastomy.