title: Testing of methyleneiminodiacetic-catechol and other aromatic chelating agents for decorporation of 238Pu and 241Am in rats.
abstract: The removal of 238Pu and 241Am by five chelating agents prepared in China was compared in pilot experiments with removal by Ca-DTPA and LICAM(C). The most promising substance is quinamic acid (a methyliminodiacetic polyquinoline derivative, code name 811 or 703-73), especially in combination with Ca-DTPA. However, the best over-all reduction of both 238Pu and 241Am in all the organs studied was achieved by Ca-DTPA-administered at a ten-fold human equivalent dosage.
authors.affiliation: Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, F.R. Germany.
authors.forename: M C
authors.initials: MC
authors.lastname: Luo
authors.forename: V
authors.initials: V
authors.lastname: Volf
mesh_terms: D000576:Americium / Q000378:metabolism*; D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage*; D005260:Female; D007546:Isoquinolines / Q000008:administration & dosage*; D004369:Pentetic Acid / Q000008:administration & dosage; D011005:Plutonium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D007546:Isoquinolines; D011005:Plutonium; C034834:LICAM-C; C032945:quinamic acid; D004369:Pentetic Acid; D013095:Spermidine; D000576:Americium