title: Identification and signal transduction mechanism of elastin peptide receptor in human leukocytes.
abstract: The existence of a novel receptor on human polymorphonuclear leukocytes (PMNLs) and monocytes was demonstrated, named soluble elastin peptide receptor. Soluble elastin peptides, like K-elastin, which are liberated from elastin fibres, can be found in the sera, and they possess several biological activities such as chemotaxis. Studying the effects of elastin peptides on leukocytes, it was found that: (i) the elastin peptide stimulates the oxidative burst, the intracellular free Ca2+ elevation through a specific receptor; and (ii) in the signal transduction mechanism of this elastin peptide receptor, the phosphatidylinositol breakdown is involved.
authors.affiliation: First Department of Medicine, Univ. Med. School, Debrecen, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Varga
authors.forename: M P
authors.initials: MP
authors.lastname: Jacob
authors.forename: L
authors.initials: L
authors.lastname: Robert
authors.forename: T
authors.initials: T
authors.lastname: Fülöp
mesh_terms: D000328:Adult; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D004549:Elastin / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism* / Q000502:physiology; D010716:Phosphatidylinositols / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction; D012995:Solubility
chemical_list: D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; C054901:elastin-binding proteins; D004549:Elastin; D002118:Calcium