title: Comparison of the increment in plasma eicosapentaenoate concentrations by fish oil intake between young and middle-aged volunteers.
abstract: The effect of age on eicosapentaenoic acid (20:5 n-3; EPA) incorporation into plasma lipids was investigated in young volunteers (8 males, 19 +/- 1 yr) and middle-aged volunteers (6 males, 53 +/- 7 yr). They were asked to take 5.4 g fish oil per day for one week. The increment in EPA in the cholesteryl ester fraction after the supplementation was significantly greater in the middle-aged group (delta = 1.69%) than in the young group (delta = 0.44%) (p less than 0.05). The food intake analyzed for 3 consecutive days just before the supplementation revealed that the young group took more linoleate (17 vs. 10 g) than the middle-aged group. There was a significant inverse correlation between the increment in EPA in the cholesteryl ester fraction after the supplementation and daily linoleate intake among all the volunteers combined (r = -0.63, p less than 0.02). The higher increment in EPA in cholesteryl ester in the middle-aged group might be due to less intake of linoleate and not due to the difference in age itself.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sawazaki
authors.forename: T
authors.initials: T
authors.lastname: Hamazaki
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Taki
authors.forename: M
authors.initials: M
authors.lastname: Kaneda
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Kuwamori
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000375:Aging / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005227:Fatty Acids / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D005227:Fatty Acids; D005395:Fish Oils; D008041:Linoleic Acids; D008055:Lipids; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid