title: [The effectiveness of foot-and-mouth disease vaccines in Switzerland. II. Stability problems].
abstract: One of the vaccines that were used in 1988 to immunize the Swiss national cattle population against foot-and mouth disease (FMD) was apparently not stable. Data, provided by the manufacturer, indicated a high initial antigenic content for serotype O. Protection experiments at the end of the vaccination campaign, however, indicated a substantial loss of serotype O antigen in the vaccine. Serological data, obtained during the campaign indicated that only 12% of the primovaccinated animals and 63% of previously vaccinated animals received an amount of FMD viral antigen sufficient to induce protective immunity. The primovaccinated animals were revaccinated in fall 1988 with a new batch provided by the same manufacturer. The new vaccine induced high titers of neutralizing antibodies in primo- and an anamnestic response in revaccinated cattle.
authors.forename: M
authors.initials: M
authors.lastname: Ackermann
authors.forename: H K
authors.initials: HK
authors.lastname: Müller
authors.forename: L
authors.initials: L
authors.lastname: Bruckner
authors.forename: U
authors.initials: U
authors.lastname: Kihm
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis; D005537:Aphthovirus / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004355:Drug Stability; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D013557:Switzerland; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D014765:Viral Vaccines
vernacular_title: Untersuchungen zur Wirksamkeit der MKS-Impfstoffe in der Schweiz II. Stabilitätsprobleme.