title: In vitro adherence of type 1-fimbriated uropathogenic Escherichia coli to human ureteral mucosa.
abstract: Type 1-fimbriated Escherichia coli isolated from patients with urinary tract infections adhered in vitro to the epithelial cell surface of an excised human ureter. The bacteria also adhered to a mucous coating and to Formalin-fixed human ureteral mucosa. D-Mannose strongly inhibited such adherence. The bacteria in their nonfimbriated phase lacked the ability to adhere. We concluded that type 1 fimbriae play a role, at least in part, in upper urinary tract infections in humans.
authors.affiliation: Department of Urology, School of Medicine, Juntendo University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: R
authors.initials: R
authors.lastname: Kitagawa
mesh_terms: D000328:Adult; D001422:Bacterial Adhesion; D002292:Carcinoma, Renal Cell / Q000382:microbiology / Q000648:ultrastructure; D004848:Epithelium / Q000382:microbiology / Q000648:ultrastructure; D004926:Escherichia coli / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000473:pathology; D005260:Female; D010861:Fimbriae, Bacterial / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology / Q000648:ultrastructure; D014515:Ureteral Diseases / Q000382:microbiology* / Q000473:pathology