Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital.
2% mupirocin ointment applied intra-nasally for 5 days was assessed for elimination of nasal carriage of Staphylococcus aureus in 31 staff members in a children's hospital. Three volunteers failed to complete the trial because of side effects, i.e. buccal reddening and swelling, and unpleasant taste. During treatment staphylococcal nasal carriage was not found in any case; of the 24 post-treatment nasal swabs taken 4 days after treatment 22 were still negative. Re-colonization with S. aureus of different phage types occurred in the remaining two cases.
Frank
U
U
Department of Hospital Epidemiology, University Hospital, Freiburg, FRG.
Lenz
W
W
Damrath
E
E
Kappstein
I
I
Daschner
F D
FD
D000281:Administration, Intranasal; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002353:Carrier State; D002648:Child; D003428:Cross Infection / Q000517:prevention & control; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D016712:Mupirocin; D009666:Nose / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D016712:Mupirocin