Anxiolytic effect of caffeine and caffeine-clonazepam interaction: evaluation by NaCl solution intake.
The administration of drugs with anxiolytic action to rehydrating rats augments the intake of 1.5% NaCl solution. In order to clarify the status of caffeine as an anxiolytic agent and its possible interaction with a benzodiazepine having high potency and efficacy in this regard, caffeine (0.78-100 mg/kg) alone and caffeine (0.78-50 mg/kg) plus clonazepam (0.05 or 0.50 mg/kg) injections (IP) were administered to rehydrating rats prior to 1-hr sessions during which they drank 1.5% NaCl solution. When given alone, caffeine, within a particular dose range, and clonazepam at both doses, augmented NaCl solution intake, but when administered in combination, caffeine antagonized the effects of clonazepam.
Tang
M
M
Department of Psychology, Rutgers University, New Brunswick, NJ 08903.
Kuribara
H
H
Falk
J L
JL
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D012462:Saline Solution, Hypertonic
D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D012462:Saline Solution, Hypertonic; D002110:Caffeine; D002998:Clonazepam