Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex.
A population of neurons situated in the human cerebral neocortex contains mRNA coding for tyrosine hydroxylase, the key enzyme for catecholamine biosynthesis. Phosphorylated neurofilament-containing cytoplasmic inclusions occur in these neurons in diffuse Lewy body disease, indicating a tendency for selective involvement that is shared with subcortical catecholamine-containing neurons. These findings are relevant to the pathophysiology of several neurologic and psychiatric illnesses in which the monoamine-containing neurons of the neocortex may participate.
Kuljis
R O
RO
Department of Neurology, Yale University School of Medicine, New Haven, CT.
Martín-Vasallo
P
P
Peress
N S
NS
D000911:Antibodies, Monoclonal; D002540:Cerebral Cortex / Q000201:enzymology*; D003704:Dementia / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology*; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D016900:Neurofilament Proteins; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D014446:Tyrosine 3-Monooxygenase