title: Prevention of experimental calcinosis by salmon calcitonin in rats.
abstract: The effects of salmon calcitonin on calcium overload and its deposition in the rat aorta was studied. Calcitonin administered 4 days to rats i.p. in doses of 10 IU/kg body weight blocked the development of calcinosis induced by a single dose of vitamin D3 (300,000 IU/kg body weight, orally). This was demonstrated biochemically, histochemically and by electron microscopic methods.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Czechoslovakia.
authors.forename: A
authors.initials: A
authors.lastname: Czirfusz
authors.forename: V
authors.initials: V
authors.lastname: Kovalcík
authors.forename: S
authors.initials: S
authors.lastname: Galbavý
authors.forename: E
authors.initials: E
authors.lastname: Drábková
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001018:Aortic Diseases / Q000517:prevention & control*; D002114:Calcinosis / Q000517:prevention & control*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D002762:Cholecalciferol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002762:Cholecalciferol; C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium