Stimulation-induced release of coexistent transmitters in the prefrontal cortex: an in vivo microdialysis study of dopamine and neurotensin release.
Extracellular fluid levels of dopamine and neurotensin in the rat prefrontal cortex were measured using in vivo microdialysis. Electrical stimulation of the median forebrain bundle resulted in increased release of both dopamine and neurotensin from the prefrontal cortex. Thus, stimulation of neurons in which dopamine and neurotensin are colocalized can evoke the in vivo release of both substances.
Bean
A J
AJ
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
During
M J
MJ
Roth
R H
RH
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis / Q000379:methods; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D009496:Neurotensin / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D018377:Neurotransmitter Agents; D009496:Neurotensin; D004298:Dopamine