Influence of the placenta on fetal plasma insulin and neonatal hepatic enzyme induction in the rat.
In order to study the placental role in controlling glucose metabolism and neonatal induction of tyrosine aminotransferase in rat liver, a comparison was made between the artificially delivered-rat feto-placental unit and the newborn littermates. The immunoreactive serum insulin in the feto-placental unit remains as high as in utero for at least 1 h whereas in the newborn rat it decreases rapidly after delivery. From Caesarian section to 6 h later, in contrast to the newborn littermates, the feto-placental unit remains hyperglycaemic. Upon glucagon injection the feto-placental unit shows a delay in the increase of the hepatic tyrosine aminotransferase activity in comparison with the newborn rat.
Goltzsch
W
W
Karl-Marx University, School of Medicine, Institute of Biochemistry, Leipzig, GDR.
Niemann
E
E
Böhme
H J
HJ
Hofmann
E
E
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D004790:Enzyme Induction; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D014444:Tyrosine Transaminase