Comparative antibacterial activity of the new cephalosporin cefcanel against anaerobic bacteria.
The activity of cefcanel against anaerobic cocci, Clostridium perfringens, Bacteroides fragilis, Bacteroides spp. and fusobacteria was determined by the agar dilution method and compared with the activity of cefaclor, cephalexin, cefadroxil, phenoxymethylpenicillin and ampicillin. Cefcanel showed good activity against Clostridium perfringens, Bacteroides spp. and fusobacteria (MIC90 = 1-4 mg/l). Against anaerobic cocci its MIC90 value was 16 mg/l, and against Bacteroides fragilis, 32 mg/l. Cefcanel has an antibacterial activity that warrants investigation in clinical trials.
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Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Lindmark
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Persson
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D000667:Ampicillin / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D001441:Bacteroides fragilis / Q000187:drug effects; D002433:Cefaclor / Q000494:pharmacology; D002434:Cefadroxil / Q000494:pharmacology; D002437:Cefazolin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects; D005673:Fusobacterium / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010404:Penicillin V / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis
D002511:Cephalosporins; D002434:Cefadroxil; C022605:cefcanel; D002433:Cefaclor; D000667:Ampicillin; D001618:beta-Lactamases; D002437:Cefazolin; D002506:Cephalexin; D010404:Penicillin V