Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs.
The effects of the enantiomers of 11-hydroxy-delta 8-tetrahydrocannabinol-dimethylheptyl (11-OH-delta 8-THC-DMH) on spontaneous activity, rectal temperature, tail-flick latency, and catalepsy were studied in mice and in the dog static-ataxia model to determine the relative potency of each enantiomer. The (-)-enantiomer was active in all tests between 3-100 micrograms/kg, while the (+)-enantiomer was inactive at 30 mg/kg in the mouse and 1 mg/kg in the dog. The (-)-enantiomer was 100-800 times more potent than delta 9-THC in the mouse. The high degree of enantioselectivity and potency are suggestive of an interaction at a specific site such as a receptor.
Little
P J
PJ
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
Compton
D R
DR
Mechoulam
R
R
Martin
B R
BR
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced*; D004285:Dogs; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013237:Stereoisomerism
C020367:11-hydroxy-delta(8)-tetrahydrocannabinol; D013759:Dronabinol