title: Train-of-four fade during onset of neuromuscular block with nondepolarising neuromuscular blocking agents.
abstract: Fade in the train-of-four (TOF) responses during onset of neuromuscular block was studied following administration of atracurium (225 or 450 micrograms/kg), vecuronium (40 or 80 micrograms/kg), pancuronium (60 or 120 micrograms/kg) and tubocurarine (450 micrograms/kg). TOF ratios were measured at approximate heights of T1 (first response in the TOF) of 75, 50 and 25%. Fade in TOF increased as the height of T1 decreased, with maximum fade being observed at T1 of 25%. The greatest difference between relaxants was observed at T1 of 25%, vecuronium showing the least fade and pancuronium, atracurium and tubocurarine showing increasing fade, in that order. The difference between atracurium and tubocurarine or between vecuronium and pancuronium was not significant, but the degree of TOF fade was significantly greater with atracurium and tubocurarine in comparison to vecuronium or pancuronium.
authors.affiliation: Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast, N. Ireland, UK.
authors.forename: F M
authors.initials: FM
authors.lastname: Gibson
authors.forename: R K
authors.initials: RK
authors.lastname: Mirakhur
mesh_terms: D000328:Adult; D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D004558:Electric Stimulation; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D010197:Pancuronium / Q000008:administration & dosage / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*; D014459:Ulnar Nerve / Q000187:drug effects; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine