Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation.
Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.
Kirkpatrick
B
B
Maryland Psychiatric Research Center, Baltimore 21228.
Buchanan
R W
RW
Maeda
K
K
Carpenter
W T
WT
Jauch
D
D
Tamminga
C A
CA
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000187:drug effects*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000097:blood*; D014268:Trifluoperazine / Q000009:adverse effects
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D014268:Trifluoperazine; D011388:Prolactin; D006220:Haloperidol; D005476:Fluphenazine