title: Detectability of thyroid anti-microsomal antibodies, changes in thyroid-stimulating immunoglobulins (TSI) and thyrotropin-binding-inhibiting immunoglobulins (TBII) during methimazole treatment of Graves' disease patients.
abstract: The prognostic value of determination of different antibodies in Graves' disease patients is questionable. The authors simultaneously assessed the generation of cAMP, the TSH-receptor binding inhibitory assay and the detectability of anti-microsomal antibodies by indirect immuno-fluorescence. The tests were performed before, during and after methimazole treatment. During a 12 months' medication all 22 patients became euthyroid. Six months after withdrawal of the drug, 15 patients were still euthyroid (Group A); 7 relapsed (Group B). Patients showing enhanced activities by all three methods, relapsed (5 out of 7 cases of Group B). The results indicate that simultaneous determination of TSI, TBII and anti-microsomal antibodies are of high prognostic value for relapses. These data should be taken into consideration for the further therapy.
authors.affiliation: First Department of Medicine, University Medical School, Debrecen, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Szabó
authors.forename: A
authors.initials: A
authors.lastname: Leövey
authors.forename: Z
authors.initials: Z
authors.lastname: Karányi
authors.forename: C
authors.initials: C
authors.lastname: Várvölgyi
authors.forename: E
authors.initials: E
authors.lastname: Fórizs
authors.forename: L
authors.initials: L
authors.lastname: Herceg
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D005067:Euthyroid Sick Syndromes / Q000276:immunology; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis*; D018828:Immunoglobulins, Thyroid-Stimulating; D008713:Methimazole / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; C056626:thyroid microsomal antibodies; D008713:Methimazole