title: Nutritive utilization of phosphorus in the rat: influence of intestinal resection and dietary medium chain triglycerides and vitamin D3.
abstract: The effects of intestinal resection and diet on the digestive and metabolic utilization of phosphorus were studied in adult rats from which 50% of the distal small intestine had been removed and in sham-operated controls. Metabolic parameters were measured both 1 and 3 months after surgery. The loss of half of the distal small intestine led to a decline in digestive utilization of phosphorus 1 month after surgery as reflected in bone mineral content. Digestive efficiency had improved by 3 months after surgery. One month's feeding with a diet in which fat was provided as equal parts of medium chain triglycerides, sunflower seed oil and olive oil instead of 100% olive oil enhanced phosphorus absorption and retention, although this improvement was less evident after 3 months. The negative effects of distal small intestine resection on the nutritive utilization of phosphorus were not only palliated but significantly enhanced by supplementing the diet with vitamin D3 at a rate of 0.08 mg/100 g diet. This dose is within physiological limits, and favors phosphorus deposition in bone tissue.
authors.affiliation: Department of Animal Physiology, Faculty of Pharmacy, University of Granada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Barrionuevo
authors.forename: M S
authors.initials: MS
authors.lastname: Campos
authors.forename: I
authors.initials: I
authors.lastname: López Aliaga
authors.forename: F
authors.initials: F
authors.lastname: Coves
authors.forename: F
authors.initials: F
authors.lastname: Lisbona
mesh_terms: D000818:Animals; D015519:Bone Density; D002762:Cholecalciferol / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000378:metabolism*; D008297:Male; D009751:Nutritional Requirements; D000069463:Olive Oil; D010758:Phosphorus / Q000378:metabolism*; D010938:Plant Oils / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000074242:Sunflower Oil; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D002762:Cholecalciferol; D010758:Phosphorus