title: Increased seizure susceptibility induced by guanidinoethane sulfonate in E1 mice and its relation to glutamatergic neurons.
abstract: Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug administration. Glutamate levels were increased in the cerebrum, and glutamine levels were increased in the cerebellum three days after starting GES administration. Brain 5-HT levels were not changed at that time. These results suggest that increased seizure susceptibility induced by GES in E1 mice is related to glutamatergic neurons.
authors.affiliation: Department of Neurochemistry, Okayama, University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hiramatsu
authors.forename: R
authors.initials: R
authors.lastname: Edamatsu
authors.forename: H
authors.initials: H
authors.lastname: Kabuto
authors.forename: Y
authors.initials: Y
authors.lastname: Higashihara
authors.forename: A
authors.initials: A
authors.lastname: Mori
mesh_terms: D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism; D051379:Mice; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D003292:Convulsants; D005971:Glutamates; D005973:Glutamine; D013654:Taurine; D012701:Serotonin; D018698:Glutamic Acid; C009558:taurocyamine