Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant.
Zonisamide is a novel anticonvulsant that prevents seizures in laboratory animals and in man. Zonisamide (3 micrograms/ml and above) blocked the sustained firing of action potentials induced by depolarizing steps of current injected across the membrane of intracellularly recorded spinal cord neurons. Responses to GABA and glutamate were not altered by zonisamide, and spontaneous synaptically evoked activity was not reduced until higher concentrations of zonisamide (10 micrograms/ml) were applied.
Rock
D M
DM
Department of Pharmacology, Parke-Davis Research Division, Warner-Lambert Company, Ann Arbor, MI 48105.
Macdonald
R L
RL
Taylor
C P
CP
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007555:Isoxazoles / Q000494:pharmacology*; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000927:Anticonvulsants; D005971:Glutamates; D007555:Isoxazoles; D010080:Oxazoles; D018698:Glutamic Acid; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid