title: Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.
authors.affiliation: Department of Biochemistry, Nucleic Acid Research Institute, Costa Mesa, CA 92626.
authors.forename: R C
authors.initials: RC
authors.lastname: Willis
authors.forename: L D
authors.initials: LD
authors.lastname: Nord
authors.forename: J M
authors.initials: JM
authors.lastname: Fujitaki
authors.forename: T S
authors.initials: TS
authors.lastname: Breen
authors.forename: S S
authors.initials: SS
authors.lastname: Matsumoto
mesh_terms: D001402:B-Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives*; D008778:Methylthioinosine / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D011685:Purine Nucleotides / Q000096:biosynthesis / Q000378:metabolism*; D011741:Pyrimidine Nucleosides / Q000494:pharmacology*; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D012268:Ribose-Phosphate Pyrophosphokinase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: C011650:NSC 283867; D011685:Purine Nucleotides; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D008778:Methylthioinosine; D007288:Inosine; D010770:Phosphotransferases; D012268:Ribose-Phosphate Pyrophosphokinase