title: Chronic pruritic eruption in patients with acquired immunodeficiency syndrome associated with increased antibody titers to mosquito salivary gland antigens.
abstract: Five of seven patients with acquired immunodeficiency syndrome (AIDS) who had pruritus and a chronic, nonspecific-appearing skin eruption had increased antibody titers to antigens in the salivary glands of Aedes taeniorhynchus, a salt marsh mosquito common to South Florida. We hypothesize that the pruritus and skin lesions in patients with AIDS represent a form of chronic "recall" reaction. Increased antibody titers to mosquito salivary gland antigens may be a consequence of nonspecific B cell activation, a feature of AIDS.
authors.affiliation: Department of Dermatology, University of Miami School of Medicine, FL.
authors.forename: N S
authors.initials: NS
authors.lastname: Penneys
authors.forename: J K
authors.initials: JK
authors.lastname: Nayar
authors.forename: H
authors.initials: H
authors.lastname: Bernstein
authors.forename: J W
authors.initials: JW
authors.lastname: Knight
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000378:metabolism; D002908:Chronic Disease; D009033:Culicidae; D006801:Humans; D007299:Insect Bites and Stings / Q000276:immunology; D007868:Leg Dermatoses / Q000209:etiology; D008297:Male; D011537:Pruritus / Q000276:immunology*; D012469:Salivary Glands / Q000276:immunology*