The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat.
The level of somatostatin in the hypothalamus was higher in satiated rats than in hungry rats. Elevating hypothalamic somatostatin levels by administering somatostatin into the hypothalamus produced a decrease in food intake, whereas lowering hypothalamic somatostatin levels by administering cysteamine into the peritoneal cavity produced an increase in food intake in rats.
Ho
L T
LT
Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan.
Chern
Y F
YF
Lin
M T
MT
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D006815:Hunger / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000502:physiology; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*
D013004:Somatostatin; D003543:Cysteamine