title: Lactic acidosis in theophylline overdose.
abstract: An 18-year-old man with theophylline overdose developed an increased anion gap metabolic acidosis. Serum lactate levels were markedly elevated. A direct correlation was found between the increasing theophylline level, clinical hyperadrenergic state, and the worsening acidosis. Early hemoperfusion reversed the acidosis, the elevated serum theophylline level, and the hyperadrenergic state. This case substantiates the role of lactate accumulation in the metabolic acidosis associated with isolated theophylline toxicity.
authors.affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
authors.forename: L J
authors.initials: LJ
authors.lastname: Leventhal
authors.forename: G
authors.initials: G
authors.lastname: Kochar
authors.forename: N H
authors.initials: NH
authors.lastname: Feldman
authors.forename: S M
authors.initials: SM
authors.lastname: Podolsky
authors.forename: M S
authors.initials: MS
authors.lastname: Stanek
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D000293:Adolescent; D000863:Antacids / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D002951:Citrates / Q000627:therapeutic use; D019343:Citric Acid; D006464:Hemoperfusion; D006801:Humans; D007486:Ipecac / Q000627:therapeutic use; D008297:Male; D013406:Suicide, Attempted; D013806:Theophylline / Q000097:blood / Q000506:poisoning*
chemical_list: D000863:Antacids; D002951:Citrates; D002606:Charcoal; D019343:Citric Acid; D007486:Ipecac; D013806:Theophylline