title: Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
abstract: 122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.
authors.affiliation: Centre René Huguenin, Saint-Cloud, France.
authors.forename: F
authors.initials: F
authors.lastname: Spyratos
authors.forename: T
authors.initials: T
authors.lastname: Maudelonde
authors.forename: J P
authors.initials: JP
authors.lastname: Brouillet
authors.forename: M
authors.initials: M
authors.lastname: Brunet
authors.forename: A
authors.initials: A
authors.lastname: Defrenne
authors.forename: C
authors.initials: C
authors.lastname: Andrieu
authors.forename: K
authors.initials: K
authors.lastname: Hacene
authors.forename: A
authors.initials: A
authors.lastname: Desplaces
authors.forename: J
authors.initials: J
authors.lastname: Rouëssé
authors.forename: H
authors.initials: H
authors.lastname: Rochefort
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000601:surgery; D002402:Cathepsin D / Q000032:analysis*; D004792:Enzyme Precursors / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011863:Radioimmunoassay
chemical_list: D014408:Biomarkers, Tumor; D004792:Enzyme Precursors; C058345:procathepsin D; D002402:Cathepsin D