Molecular genetic studies in schizophrenia.
Despite many years of research, the genetic factors in schizophrenia are not well understood. Recent developments in DNA technology allow new methods of testing genetic hypotheses in the etiology of this debilitating disorder. We have found evidence against linkage of schizophrenia in a Swedish kindred to markers on chromosome 5; another research group has reported positive evidence for linkage to this same chromosomal region in British and Icelandic families. This article presents a set of data expanded from our previous report, discusses the issue of heterogeneity, and reviews the current status of linkage studies in schizophrenia.
Kennedy
J L
JL
Dept. of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.
Giuffra
L A
LA
Moises
H W
HW
Wetterberg
L
L
Sjögren
B
B
Cavalli-Sforza
L L
LL
Pakstis
A J
AJ
Kidd
J R
JR
Kidd
K K
KK
D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage; D006801:Humans; D007055:Iceland; D008126:Lod Score; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D006113:United Kingdom