title: [G proteins: GTP binding proteins in signal transduction].
abstract: A family of GTP-binding proteins (G proteins) couples receptors for hormones and neurotransmitters to diverse effectors in the cell. G proteins are membrane-bound GTPases composed of three distinct polypeptides. Cyclic AMP production, phosphoinositide breakdown, and ion channels are all known to be regulated via G proteins. Functional characterization, protein purification, labelling with bacterial toxins, specific antibodies and molecular cloning are tools which have helped to provide information on these proteins. Although the molecular properties of several G proteins are well known, the correct functional assignments are complex. Furthermore, we do not know how the various signal systems are involved in regulation of G protein activity.
authors.forename: T B
authors.initials: TB
authors.lastname: Haugen
mesh_terms: D000818:Animals; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018377:Neurotransmitter Agents; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins
vernacular_title: G-proteiner: GTP-bindende proteiner i signaloverføring.