title: Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.
abstract: Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Takamiya
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Oya
authors.forename: T
authors.initials: T
authors.lastname: Ozawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kagawa
mesh_terms: D003342:Corpus Striatum / Q000201:enzymology*; D014450:Electron Transport Complex III / Q000302:isolation & purification; D003576:Electron Transport Complex IV / Q000302:isolation & purification; D006801:Humans; D015151:Immunoblotting; D046911:Macromolecular Substances; D008928:Mitochondria / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone); D010101:Oxygen Consumption; D010300:Parkinson Disease / Q000201:enzymology*; D011808:Quinone Reductases / Q000172:deficiency* / Q000302:isolation & purification / Q000378:metabolism; D012016:Reference Values
chemical_list: D046911:Macromolecular Substances; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D003576:Electron Transport Complex IV; D014450:Electron Transport Complex III