title: Hyperosmolality due to antacid treatment.
abstract: Magnesium trisilicate mixture is an antacid used commonly in our Intensive Care Unit in the prevention and treatment of stress ulcers. In this case the administration of large doses over a period of time led to the development of massive hyperosmolality, cerebral dehydration and coma. Management with hypotonic fluid resulted in complete recovery.
authors.affiliation: Anesthesiology Department, Ibn Sina Hospital, Kuwait.
authors.forename: J H
authors.initials: JH
authors.lastname: Faraj
mesh_terms: D000863:Antacids / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D005440:Fluid Therapy; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D008274:Magnesium / Q000009:adverse effects*; D017633:Magnesium Silicates; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012824:Silicic Acid / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000009:adverse effects*; D012964:Sodium / Q000097:blood
chemical_list: D000863:Antacids; D017633:Magnesium Silicates; D012824:Silicic Acid; D012822:Silicon Dioxide; D012964:Sodium; C001671:magnesium trisilicate; D008274:Magnesium