[Wound healing, blood coagulation and fibrinolysis during operations involving gastric cancer surgery].
Serial changes of FPA, FPB beta 15-42, FN, XIIIa, and alpha 2PI were investigated for the study on wound healing, blood coagulation, and fibrinolysis during gastric cancer surgery. For a control, we compared the preoperative values with the postoperative ones. These results also were compared with the values in healthy volunteers and in patients with cholelithiasis or myoma uteri. Our findings were as follows; 1) Compared with the control values, a statistically significant elevation of FPA, FPB beta 15-42 and FPA/FPB beta 15-42 ratios in patients with gastric cancer was noticed after operation. 2) Compared with the control values, a statistically marked decrease of FN, XIIIa and alpha 2PI in patients with gastric cancer was observed after operation. 3) The preoperative FPA and FPB beta 15-42 levels of gastric cancer patients were appreciably greater than those of normal healthy volunteers. Compared with patients with cholelithiasis or myoma uteri, however, the only preoperative FPA of gastric cancer patients showed significantly high levels. 4) FN and alpha 2PI revealed a notable positive correlation. These results suggest (1) increase of coagulation activity (thrombin formation) in gastric cancer patients; (2) increase of intravascular coagulation and fibrinolytic activity (thrombin and plasmin formation) during gastric cancer surgery; and, (3) depression of FN, XIIIa and alpha 2PI during surgery was due to sequestration at the site of tissue injury.
Gando
S
S
Department of Emergency and Critical Care Medicine, Sapporo City General Hospital, Japan.
Kamiya
K
K
Makise
H
H
Tedo
I
I
Nakanishi
Y
Y
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D002769:Cholelithiasis / Q000097:blood / Q000601:surgery; D005176:Factor XIII / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D005342:Fibrinolysis; D005344:Fibrinopeptide A / Q000378:metabolism; D005345:Fibrinopeptide B / Q000378:metabolism; D005353:Fibronectins / Q000097:blood; D006801:Humans; D007432:Intraoperative Period; D007889:Leiomyoma / Q000097:blood / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D013274:Stomach Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D011503:Transglutaminases; D014594:Uterine Neoplasms / Q000097:blood / Q000601:surgery; D014945:Wound Healing; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D010446:Peptide Fragments; D000979:alpha-2-Antiplasmin; C033786:fibrinogen Bbeta (15-42); D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005176:Factor XIII; D011503:Transglutaminases