title: Atrial natriuretic factor suppresses neural stimulation of renin release in dogs.
abstract: The effects of atrial natriuretic factor (ANF) on neural control of renin release and sodium excretion by the kidney were examined in pentobarbital-anesthetized dogs. Electrical stimulation of the renal nerves (RNS, 1 Hz) increased the renal secretion rate of renin (RSR) by 627 +/- 141 ng angiotensin I (ANG I)/min and that of norepinephrine (NESR) by 22.2 +/- 5.9 ng/min. Furthermore, urinary sodium excretion (UNaV) was decreased by 59 +/- 7%, with little change in either renal blood flow (RBF) or glomerular filtration rate (GFR). Intrarenal arterial infusion of ANF (alpha-human atrial natriuretic peptide; 10 ng.kg-1.min-1) increased basal UNaV about twofold but had no effect on basal RBF or GFR. The RNS-induced increase in RSR during ANF infusion (198 +/- 117 ng ANG I/min) was significantly lower than that before the infusion (P less than 0.05), whereas the RNS-induced changes in NESR (27.1 +/- 8.5 ng/min) and UNaV (51 +/- 11%) were unaffected. These results suggest that neural stimulation of renin release, but not of tubular sodium reabsorption, can be suppressed by exogenously administered ANF at a dose that does not affect glomerular filtration or renal neurotransmitter release.
authors.affiliation: Department of Pharmacology, Tohoku University, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hisa
authors.forename: Y
authors.initials: Y
authors.lastname: Tomura
authors.forename: S
authors.initials: S
authors.lastname: Satoh
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000294:innervation / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism / Q000652:urine
chemical_list: D018377:Neurotransmitter Agents; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin; D009638:Norepinephrine