title: [Genetic instability and transposition of mobile element mdg4 in a mutator strain of Drosophila melanogaster].
abstract: Laboratory mutator strain of Drosophila melanogaster is characterized by increased (up to 10(-3)-10(-4) frequency of spontaneous mutability. Mutations appear in premeiotic stages of gametes development. The majority of mutations were unstable (high frequencies of reversions, appearance of new mutations at the same and other loci, replicating instability). Localization of mobile elements mdg1, mdg2, mdg3, mdg4, copia and P element in X chromosomes of mutator individuals and its mutations y, ct, sbt was studied by hybridization in situ. In all strains P element was absent. The distribution of mdg1, mdg2, mdg3 and copia was identical in mutator strains and its derivatives, but distribution of mdg4 was different. The essential heterogeneity in localization of mdg4 and increased (up to 30-40) copy number in the mutator strain individuals was observed. The ability of single element mdg4 to autonomous transpositions was thus shown.
authors.forename: A I
authors.initials: AI
authors.lastname: Kim
authors.forename: E S
authors.initials: ES
authors.lastname: Beliaeva
authors.forename: Z G
authors.initials: ZG
authors.lastname: Larkina
authors.forename: M M
authors.initials: MM
authors.lastname: Aslanian
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D008297:Male; D009154:Mutation; D014960:X Chromosome
chemical_list: D004251:DNA Transposable Elements
vernacular_title: Geneticheskaia nestabil'nost' i transpozitsii mobil'nogo élement MDG4 v mutatornoĭ linii Drosophila melanogaster.