Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.
McCall
T B
TB
Wellcome Research Laboratories, Kent, U.K.
Boughton-Smith
N K
NK
Palmer
R M
RM
Whittle
B J
BJ
Moncada
S
S
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D001798:Blood Proteins / Q000096:biosynthesis*; D007975:Leukotriene B4 / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D010974:Platelet Aggregation; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000378:metabolism*; D019323:omega-N-Methylarginine
D001798:Blood Proteins; C052788:platelet inhibitory factor; D013481:Superoxides; D007975:Leukotriene B4; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D009240:N-Formylmethionine Leucyl-Phenylalanine; D001120:Arginine