title: Famotidine in the treatment of duodenal ulcers resistant to other histamine H2-receptor antagonists.
abstract: In 20% of patients with duodenal ulcers, treatment is ineffective. Ulcers are considered resistant when they fail to heal following 8-12 weeks of treatment with full dose duodenal ulcer therapy. The present study reviewed the records and endoscopic findings of 73 patients who were considered by their physicians to have resistant duodenal ulcers. From this population, 15 patients with documented, active duodenal ulcers were chosen to participate in this study. Each had failed treatment with cimetidine or ranitidine at recommended doses administered for from 56 days to more than 2 years. After up to 6 weeks' treatment with 20 mg famotidine given twice daily, eight patients showed endoscopic evidence of healing (S1 or S2) based on the criteria established by the Japanese Society of Digestive Endoscopy. Five others showed moderate to marked improvement H1-H3). No patient experienced side-effects during famotidine treatment. The greater antisecretory effect of famotidine may be useful in treating duodenal ulcer patients who fail to heal with cimetidine or ranitidine.
authors.affiliation: Department of Internal Medicine, Taipei Medical College, Taiwan.
authors.forename: P H
authors.initials: PH
authors.lastname: Chen
authors.forename: T H
authors.initials: TH
authors.lastname: Wang
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: T C
authors.initials: TC
authors.lastname: Cheng
authors.forename: Y T
authors.initials: YT
authors.lastname: Tsai
authors.forename: C P
authors.initials: CP
authors.lastname: Siauw
authors.forename: K C
authors.initials: KC
authors.lastname: Yang
authors.forename: G H
authors.initials: GH
authors.lastname: Chen
authors.forename: J L
authors.initials: JL
authors.lastname: Sung
mesh_terms: D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D015738:Famotidine; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D013844:Thiazoles; D015738:Famotidine