Suboptimal effect of daptomycin in the treatment of bacteremias.
We have reported two cases involving bacteremic patients who failed to respond adequately to the investigational agent daptomycin. Despite apparent sensitivity of the organisms, therapy was unsuccessful in both patients using the recommended dosage. The sponsor of daptomycin is currently reevaluating the recommendation and may be revising their dosage guidelines in the future.
Garrison
M W
MW
Section of Clinical Pharmacology, St. Paul-Ramsey Medical Center, Minn 55101.
Rotschafer
J C
JC
Crossley
K B
KB
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D017576:Daptomycin; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy*; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin