Some theoretical aspects of the mechanism of action of benzhydrazone, an inhibitor of glycosylation in herpes simplex virus.
Some hypotheses of the mechanism of action of benzhydrazone, a selective inhibitor of herpes simplex virus glycoprotein biosynthesis, are presented in this paper. Comparative analysis of different models indicates that the drug may interfere with herpes simplex virus DNA. Thus, benzhydrazone seems to act like a bifunctional alkylating agent.
Paganetto
G
G
Institute of Biological Sciences, School of Medicine, University of Verona, Italy.
Palù
G
G
Tognon
M
M
D000998:Antiviral Agents / Q000494:pharmacology*; D004279:DNA, Viral / Q000187:drug effects*; D006031:Glycosylation; D006835:Hydrazones / Q000494:pharmacology*; D008956:Models, Chemical; D015394:Molecular Structure; D018139:Simplexvirus / Q000187:drug effects*
D000998:Antiviral Agents; D004279:DNA, Viral; D006835:Hydrazones; C027566:benzhydrazone