Electrophysiological and pharmacological properties of putative A13 incertohypothalamic dopamine neurons in the rat.
A13 incertohypothalamic dopamine (DA) neurons were labelled with antibodies raised to tyrosine hydroxylase in the male rat. Electrophysiologically, these neurons could be distinguished from their neighboring non-DA cells by their wide action potentials (greater than 2 ms), slow firing rates (0-3.8 impulses/s) and by the ability of iontophoresed DA and systemically administered apomorphine to inhibit impulse flow. Low doses of the antipsychotic drug haloperidol attenuated DA's response and reversed the apomorphine-inhibition of impulse flow.
Sanghera
M K
MK
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine