The trophic effects of gastrin on fundic neuroendocrine cells of the rat stomach.
The histomorphological effect of multidose administration of 6 mg/kg pentagastrin b.d. for 5 weeks, and 1000 mg/kg sodium bicarbonate b.d. for 13 weeks, on the rat fundic mucosa has been examined. Sodium bicarbonate induced a significant hypergastrinaemia (plasma gastrin concentrations were 370.5 pg/ml in the control versus 642.6 pg/ml in sodium bicarbonate-treated rats after 13 weeks, P less than 0.01). Both treatment regimens induced fundic neuroendocrine cell hyperplasia. The cellular proliferation that occurred following hypergastrinaemia of endogenous or exogenous origin suggests that systemic gastrin concentrations play a major role in the control of fundic neuroendocrine cell populations.
Eason
C T
CT
Toxicology Department, Sterling-Winthrop Research Centre, Alnwick, Northumberland, UK.
Spencer
A J
AJ
Pattison
A
A
Bonner
F W
FW
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D005748:Gastric Fundus / Q000166:cytology / Q000187:drug effects*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D005755:Gastrins / Q000494:pharmacology*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D015290:Second Messenger Systems / Q000187:drug effects; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D005755:Gastrins; D017693:Sodium Bicarbonate; D012964:Sodium; D010418:Pentagastrin