Chronic electroconvulsive shock and neurotransmitter receptors--an update.
Electroconvulsive shock (ECS) produces many neurochemical alterations which may be related to its efficacy in the treatment of different psychiatric disorders. This review focuses particularly on experimental findings of CNS receptor changes in animals following chronic ECS and relates them to neurotransmitter and behavioral changes. Also, the pharmacological effect of other antidepressant treatment are compared. Possible mechanisms of action are discussed.
Gleiter
C H
CH
Laboratory of Clinical Studies, DICBR, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.
Nutt
D J
DJ
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D004597:Electroshock; D018377:Neurotransmitter Agents / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D015290:Second Messenger Systems
D015220:Calcium Channels; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface