[Carcinogenic activity of synthetic chrysotile asbestos with various fiber sizes and chemical composition].
Synthetic Mg-chrysotiles (analogous to natural ones by chemical composition) with fine short, thick short and fine long fibres under intrapleural injections (20 mg thrice) induced mesotheliomas in noninbred rats in 3.3, 0 and 12% of rats, respectively. Ni- and Co-chrysotiles with fine and short fibres caused such tumours in 7.6 and 30.2%, Co-chrysotile with plate-like fibres induced tumours in 26.8%. The role of chemical structure and particle sizes have been discussed.
Vasil'eva
L A
LA
Pylev
L N
LN
Vezentsev
A I
AI
Smolikov
A A
AA
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D017632:Asbestos, Serpentine; D002273:Carcinogens / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000453:epidemiology; D010316:Particle Size; D051381:Rats; D012307:Risk Factors; D013329:Structure-Activity Relationship
D017632:Asbestos, Serpentine; D002273:Carcinogens; D001194:Asbestos
Kantserogennaia aktivnost' sinteticheskikh khrizatil-asbestov s razlichnymi razmerami volokon i khimicheskim sostavom.