Increased seizure susceptibility induced by guanidinoethane sulfonate in E1 mice and its relation to glutamatergic neurons.
Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug administration. Glutamate levels were increased in the cerebrum, and glutamine levels were increased in the cerebellum three days after starting GES administration. Brain 5-HT levels were not changed at that time. These results suggest that increased seizure susceptibility induced by GES in E1 mice is related to glutamatergic neurons.
Hiramatsu
M
M
Department of Neurochemistry, Okayama, University Medical School, Japan.
Edamatsu
R
R
Kabuto
H
H
Higashihara
Y
Y
Mori
A
A
D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism; D051379:Mice; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology
D003292:Convulsants; D005971:Glutamates; D005973:Glutamine; D013654:Taurine; D012701:Serotonin; D018698:Glutamic Acid; C009558:taurocyamine