Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.
Family studies of IgE responses to common inhaled antigens have suggested dominant inheritance of atopy. Molecular genetic linkage analysis was used to confirm this proposal. In seven families the transmission of atopy was linked, with a maximum lod score of 5.58, to a DNA polymorphism defined by p lambda MS.51, which confirms dominant inheritance and assigns the gene locus to chromosome 11.
Cookson
W O
WO
Osler Chest Unit, Churchill Hospital, Oxford.
Sharp
P A
PA
Faux
J A
JA
Hopkin
J M
JM
D001249:Asthma / Q000235:genetics* / Q000276:immunology; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000235:genetics*; D008540:Meiosis; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics* / Q000276:immunology; D012882:Skin Tests
D015342:DNA Probes; D007073:Immunoglobulin E