title: Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells.
abstract: Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.
authors.affiliation: Department of Cell Biology and Genetics, Erasmus Univesity, Rotterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Geurts van Kessel
authors.forename: E
authors.initials: E
authors.lastname: van Drunen
authors.forename: B
authors.initials: B
authors.lastname: de Jong
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: A
authors.initials: A
authors.lastname: Langeveld
authors.forename: M P
authors.initials: MP
authors.lastname: Mulder
mesh_terms: D000782:Aneuploidy; D015139:Blotting, Southern; D002881:Chromosomes, Human, Pair 12; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013736:Testicular Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D005819:Genetic Markers