Tumorigenic and metastatic ability of SV40-transformed BALB/c cell lines and MHC antigen expression.
Tumorigenic and metastatic potential were studied in relation to class I MHC expression in four different SV40-transformed BALB/c cell lines. All the lines studied, tumorigenic or not, expressed both H-2Kd and Dd, so MHC antigens did not seem to be involved in the control of SV40-transformed cells' growth in vivo. Lung metastases were observed in all tumour-bearing mice. Cells cultured after in vivo passage, obtained either from tumour tissue or from individual lung metastases, still expressed similar levels of H-2d antigens, thus suggesting that tumour growth and metastasis do not occur through the selection of variants with altered MHC expression.
De Giovanni
C
C
Istituto di Cancerologia, Università di Bologna, Italy.
Nicoletti
G
G
Del Re
B
B
Scotlandi
K
K
Prodi
G
G
Lollini
P L
PL
Nanni
P
P
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology; D000961:Antilymphocyte Serum; D015197:Carcinogenicity Tests; D002461:Cell Line, Transformed; D003602:Cytotoxicity, Immunologic; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D013539:Simian virus 40
D000952:Antigens, Polyomavirus Transforming; D000961:Antilymphocyte Serum; D006183:H-2 Antigens