Plasma ouabain-like activity in essential hypertensive patients and in subjects with primary aldosteronism.
Plasma from 37 essential hypertensive patients, from 11 subjects with primary aldosteronism and from 23 normotensive subjects was tested for ouabain-like activity. Despite a very substantial overlap, hypertensive patients (both essential and secondary) showed significantly higher levels of a ouabain-like plasma factor compared to normotensive controls. No substantial differences could be detected, however, between the two forms of hypertension; in particular, no significant changes were observed in the low-PRA subgroup. Our results are hardly compatible with the hypothesis that this substance may be of crucial importance in the development either of essential hypertension or of primary aldosteronism.
Delva
P
P
Department of Clinical Medicine, University of Verona, Italy.
Degan
M
M
Capra
C
C
Fallo
F
F
Mantero
F
F
Menegazzi
M
M
Lechi
C
C
Steele
A
A
Lechi
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D012083:Renin / Q000097:blood; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000502:physiology
D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D010042:Ouabain; D004077:Digoxin; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase