Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.
The N-methyl-D-aspartate (NMDA) receptor may play a critical role in learning and memory. In the present study, a significant correlation was found between the number of NMDA-displaceable, Na+-independent L-[3H]glutamate binding sites in the hippocampus and neocortex of young rats and the mean number of errors during retention, but not acquisition, in a 14-unit T-maze.
Wenk
G L
GL
Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218.
Grey
C M
CM
Ingram
D K
DK
Spangler
E L
EL
Olton
D S
DS
D000818:Animals; D004193:Discrimination Learning / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D009042:Motivation / Q000502:physiology; D009949:Orientation / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*; D009435:Synaptic Transmission
D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter