Stimulation of clones specific for dsDNA or idiotypes of anti-dsDNA as a consequence of BK virus inoculation.
The human polyoma virus BK (BKV) has a 5 Kbp double-stranded (ds) DNA genome packed with host cell histones into a minichromosome. Two out of 5 rabbits inoculated with infectious BKV produced detectable anti-dsDNA antibodies. In two additional rabbits antibodies against idiotypes of anti-dsDNA antibodies were elicited. These findings strongly indicate the existence of immunocompetent anti-dsDNA clones which are regulated, at least in part, through a network mechanism by anti-idiotype antibodies.
Rekvig
O P
OP
Department of Immunology, University of Tromsø School of Medicine, Norway.
Flaegstad
T
T
Fredriksen
K
K
Traavik
T
T
D000818:Animals; D001739:BK Virus / Q000276:immunology*; D002999:Clone Cells; D004247:DNA / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007140:Immunoglobulin Fab Fragments / Q000302:isolation & purification; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D011120:Polyomavirus / Q000276:immunology*; D011817:Rabbits; D014412:Tumor Virus Infections / Q000276:immunology*
D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; D004247:DNA