[The use of siliceous immunosorbents in hemosorption].
Experiments were conducted on rabbits and monkeys for approbation of immunosorbents by covalent immobilization of human serum albumin or antibodies to human apoprotein B on the surface of silo-chromium and subsequent incubation with 1% albumin solution. Extracorporeal immunosorption in immunized rabbits led to reduction of the level of specific antibodies by 60% and the number of blood platelets by 10-30%. The initial antibody level was restored in 5-10 days. Study of immunosorbents on monkeys showed a satisfactory compatibility of the sorbent with blood, its ability for regeneration, and the possibility of its repeated use. The specific capacity was 66% of the capacity according to human apoprotein B.
Kulaev
D V
DV
Andrianova
I P
IP
Zuevskiĭ
V V
VV
Liukova
T K
TK
Silant'eva
O V
OV
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000627:therapeutic use*; D001055:Apolipoproteins B / Q000276:immunology; D001772:Blood Cell Count; D005069:Evaluation Studies as Topic; D006464:Hemoperfusion / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007114:Immunization; D007164:Immunosorbents / Q000627:therapeutic use*; D010215:Papio; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology; D012822:Silicon Dioxide; D013997:Time Factors
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B; D007164:Immunosorbents; D012709:Serum Albumin; D012822:Silicon Dioxide
Ispol'zovanie kremnezemnykh immunosorbentov v gemosorbtsii.