A formalin-inactivated whole SIV vaccine confers protection in macaques.
A vaccine against human immunodeficiency virus (HIV) would be highly effective in stopping the acquired immunodeficiency syndrome (AIDS) epidemic. A comprehensive evaluation of potential vaccine methodologies can be made by means of the simian model for AIDS, which takes advantage of the similarities in viral composition and disease potential between simian immunodeficiency virus (SIV) infection of rhesus macaques and HIV infection in humans. Immunization with a formalin-inactivated whole SIV vaccine potentiated with either alum and the Syntex adjuvant threonyl muramyl dipeptide (MDP) or MDP alone resulted in the protection of eight of nine rhesus monkeys challenged with ten animal-infectious doses of pathogenic virus. These results demonstrate that a whole virus vaccine is highly effective in inducing immune responses that can protect against lentivirus infection and AIDS-like disease.
Murphey-Corb
M
M
Delta Regional Primate Research Center, Tulane University, Covington, LA 70434.
Martin
L N
LN
Davison-Fairburn
B
B
Montelaro
R C
RC
Miller
M
M
West
M
M
Ohkawa
S
S
Baskin
G B
GB
Zhang
J Y
JY
Putney
S D
SD
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology / Q000031:analogs & derivatives; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000534:Alum Compounds / Q000008:administration & dosage; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D005557:Formaldehyde; D007117:Immunization, Secondary; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000382:microbiology; D008253:Macaca mulatta; D012192:Retroviridae Infections / Q000517:prevention & control*; D012191:Retroviridae Proteins / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014771:Virion / Q000276:immunology
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D000914:Antibodies, Viral; D012191:Retroviridae Proteins; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D005557:Formaldehyde; C041524:aluminum sulfate; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C054064:N-acetylmuramyl-threonyl-isoglutamine