Spectroscopic analysis of charge transfer complex formation between neuroleptics and iodine.
Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1:1 stoichiometry and of n-sigma type with these molecules. The values of the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can therefore be expected to interfere with thyroid metabolism.
Comby
F
F
Jambut-Absil
A C
AC
Buxeraud
J
J
Raby
C
C
D014150:Antipsychotic Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D007455:Iodine / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D014150:Antipsychotic Agents; D007455:Iodine