Effect of dietary sodium on the Na-K ATPase inhibitor in patients with essential hypertension.
To study the circulating humoral factor modifying transmembrane sodium transport, plasma was obtained from 12 patients with essential hypertension (EH) fed a high sodium diet (NaCl 15 to 17 g/d) for seven days and thereafter a low sodium diet (NaCl 2 to 3 g/d) for seven days. Ouabain-sensitive 86Rb+ influx into the red blood cells (RBC) obtained from a healthy subject, and incubated with the plasma obtained during the high sodium diet was significantly lower than that incubated with the plasma obtained during the low sodium diet (3.74 +/- 0.26 v 3.97 +/- 0.30 nmol/10(8) cells, P less than .05). The changes in mean blood pressure from the high to low sodium diet showed a significant positive correlation with the changes in the ouabain-sensitive Rb influx into RBC in the plasma from the high to low sodium diet. These results suggest that a humoral factor modifying the sodium pump might be altered by sodium balance in EH, especially in salt-sensitive hypertension.
Ashida
T
T
Department of Medicine, National Cardiovascular Center, Osaka, Japan.
Kuramochi
M
M
Kojima
S
S
Yoshimi
H
H
Kawano
Y
Y
Kimura
G
G
Abe
H
H
Imanishi
M
M
Yoshida
K
K
Kawamura
M
M
D000450:Aldosterone / Q000097:blood; D001692:Biological Transport / Q000187:drug effects; D001798:Blood Proteins; D001835:Body Weight / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011506:Proteins; D012083:Renin / Q000097:blood; D012414:Rubidium Radioisotopes; D012982:Sodium, Dietary / Q000493:pharmacokinetics / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D000097795:ATPase Inhibitory Protein
D000450:Aldosterone; D001798:Blood Proteins; D011506:Proteins; D012083:Renin; D012414:Rubidium Radioisotopes; D012982:Sodium, Dietary; D000254:Sodium-Potassium-Exchanging ATPase; D000097795:ATPase Inhibitory Protein