title: Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation.
abstract: Arjunolic acid, an oleanene-type triterpene isolated from the rhizome of Cochlospermum tinctorium, its triacetate derivative, and their methyl esters were tested using the short-term in vitro assay on EBV-EA activation in Raji cells induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Their inhibitory effects on skin tumor promotors were found to be greater than those of previously studied natural products.
authors.affiliation: Department of Pharmacognosy, U.L.B, Bruxelles, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Diallo
authors.forename: M
authors.initials: M
authors.lastname: Vanhaelen
authors.forename: R
authors.initials: R
authors.lastname: Vanhaelen-Fastré
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: M
authors.initials: M
authors.lastname: Kozuka
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010946:Plants, Medicinal / Q000032:analysis*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D014315:Triterpenes; C061640:arjunolic acid