Rapid clearance of Plasmodium yoelii-infected erythrocytes after exposure to the ionophore A23187.
1. The effects of Ca2+ and the calcium ionophore A23187 on the intraerythrocytic development of the asexual forms of Plasmodium yoelii were examined. 2. Erythrocyte-free parasites obtained by saponin lysis of infected cells remained viable after exposure to 1 mM Ca2+. 3. A23187 inhibited the growth of P. yoelii and the inhibition was augmented by Ca2+ in cells infected with parasites at young stage of development. 4. A23187-treated infected cells disappeared from the circulation shortly after intravenous injection and this disappearance was profound in infected cells treated with the ionophore in the presence of Ca2+.
Tanabe
K
K
Department of Medical Zoology, Osaka City University Medical School, Japan.
Doi
S
S
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology*; D005260:Female; D008288:Malaria / Q000097:blood*; D051379:Mice; D008813:Mice, Inbred ICR; D010967:Plasmodium yoelii / Q000187:drug effects / Q000502:physiology
D000001:Calcimycin; D002118:Calcium