Reduced natural killer cell activity in major depression: neuroendocrine implications.
Natural killer cell activity (NKCA) was significantly reduced in a group of depressed patients, melancholic subtype, compared to sex- and age-matched controls. Corticotropin and cortisol values were significantly higher in the depressed subjects than in the controls, but no correlation between high hormone levels and low immunological activity was found in the patients.
Nerozzi
D
D
Department of Experimental Medicine, University of Rome, Italy.
Santoni
A
A
Bersani
G
G
Magnani
A
A
Bressan
A
A
Pasini
A
A
Antonozzi
I
I
Frajese
G
G
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003602:Cytotoxicity, Immunologic; D003863:Depression / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007694:Killer Cells, Natural / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone