Biochemical aspects of the resistance to nourseothricin (streptothricin) of Escherichia coli strains.
In most cases Escherichia coli strains phenotypically resistant against nourseothricin (streptothricin) harbour a plasmid which codes for an acetyltransferase. This enzyme transfers an acetyl group from acetyl-coenzyme A to an amino group of the beta-lysine (peptide) chain of the antibiotic, thus inactivating it. Additionally, the penetrability for nourseothricin of the cell wall is drastically reduced in a high percentage of the resistant strains. Both resistance mechanisms seem to be independent of each other.
Seltmann
G
G
Institute of Experimental Epidemiology, Wernigerode, DDR.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D010539:Permeability; D013309:Streptothricins / Q000378:metabolism / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013309:Streptothricins