Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells.
Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that nephroblastomas are polyclonal tumors containing rearranged proviral genomes. Rearrangements occur preferentially in the gag-pol region of the MAV1 proviral genome, and similar rearrangements can be detected in well-developed independent tumors.
Soret
J
J
Laboratoire d'Oncologie Virale et Moléculaire, Institut Curie, Orsay, France.
Dambrine
G
G
Perbal
B
B
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics*; D002645:Chickens; D004273:DNA, Neoplasm / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D009396:Wilms Tumor / Q000235:genetics / Q000382:microbiology* / Q000473:pathology
D004273:DNA, Neoplasm; D004279:DNA, Viral