[Experimental antioxidant therapy in toxic liver damage from CCl4 and chloxyl].
The authors studied the pharmacotherapeutic efficacy of antioxidants vitamin E, sodium selenite, and their combination in damage to rat liver by CCl4 and the anthelmintic agent chloxyl. Changes of the intensity of peroxidation of biological membrane lipids, the activity of enzymes-markers of hepatocyte cytolysis--alanine aminotransferase and aspartate aminotransferase--in blood serum, and changes in the structure of the liver were studied. Antioxidants and their combination blocked lipid peroxidation, reduced the activity of alanine aminotransferase and aspartate aminotransferase in blood serum considerably, and caused a protective effect on the structure of rat liver in its damage by CCl4 and chloxyl.
Vinogradova
L F
LF
Mirzoian
Zh A
ZhA
Kharlitskaia
E V
EV
Beketova
T P
TP
D000208:Acute Disease; D000818:Animals; D000871:Anthelmintics / Q000506:poisoning*; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D012643:Selenium / Q000627:therapeutic use; D018038:Sodium Selenite; D014810:Vitamin E / Q000627:therapeutic use; D014992:Xylenes / Q000506:poisoning*
D000871:Anthelmintics; D000975:Antioxidants; D014992:Xylenes; D014810:Vitamin E; C000294:hexachloro-4-xylene; D012643:Selenium; D018038:Sodium Selenite
Eksperimental'naia terapiia antioksidantami pri toksicheskom povrezhdenii pecheni CCl4 i khloksilom.