Liver-cell adenoma in an epileptic man on barbiturates.
The case of a 19-year-old epileptic man with a solitary hepatic adenoma is described. The tumor was 9 x 8.5 x 6.5 cm in size and microscopically consisted of cells similar in appearance to non-neoplastic hepatocytes, arranged in cords with slit-like sinusoids interposed. Bile ducts and portal tracts were conspicuously absent. Our patient was on antiepileptic drugs, among them phenobarbital which experimentally produces liver cell tumors in mice and rats.
Vázquez
J J
JJ
Department of Pathology, University of Navarra, Pamplona, Spain.
Marigil
M A
MA
D000328:Adult; D001463:Barbiturates / Q000009:adverse effects* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D001463:Barbiturates