[Low molecular weight heparin: an real alternative in thrombolysis in hemodialyzed patients. A trial of coronary thrombolysis].
Fibrinolytic treatments pose serious problems in subjects at high risk for hemorrhage, such as those requiring chronic dialysis. A 36-year-old patient requiring dialysis for the last 14 years due to chronic kidney failure was hospitalized for unstable angina combined with calcified mitral stricture. Prompt coronary arteriography revealed recent intracoronary thrombi. The failure of drug treatment and the surgical indication in light of unstable angina led the authors to use low-molecular-weight heparin b.i.d. for 12 days with monitoring of laboratory parameters (anti-Xa activity, APTT). No thrombotic or hemorrhagic episode was recorded. Control angiography indicating partial lysis of the left and right intracoronary thrombi led to exact evaluation of the residual underlying stenoses. A double aortocoronary bypass was subsequently performed combined with replacement of the mitral valve. This case gives a glimpse of the potential value of low-molecular-weight heparin as a valid alternative to conventional fibrinolysis in subjects requiring dialysis.
Montserrat
P
P
Hôpital Cardiologique, Pessac.
Brottier
L
L
Ricard
D
D
Vergnes
C
C
Benchimol
D
D
Baudet
E
E
Boisseau
M
M
Bricaud
H
H
D000328:Adult; D003327:Coronary Disease / Q000209:etiology*; D003328:Coronary Thrombosis / Q000188:drug therapy / Q000209:etiology*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D006435:Renal Dialysis
D006495:Heparin, Low-Molecular-Weight
L'héparine de bas poids moléculaire: alternative réelle dans la thrombolyse chez le dialysé? Essai de thrombolyse coronaire.