title: Survival of patients with glioblastoma multiforme treated by intraoperative high-activity cobalt 60 endocurietherapy.
abstract: The authors report their initial treatment results in 49 patients with glioblastoma multiforme (GM) who received intraoperative endocurietherapy (ECT) with high-activity cobalt 60 (60Co) probe. Thirty poor prognosis (unresectable tumor) patients (Group I) with newly diagnosed GM were treated by either biopsy or subtotal excision, followed by 20.00-Gy single-fraction 60Co probe ECT, and 60.00-Gy external-beam radiation therapy (EXRT) (80.00 Gy total tumor dose). Nineteen patients (Group II) with recurrent, previously resected and externally irradiated GM were retreated with 20.00-Gy single-fraction 60Co probe ECT alone. The authors' initial experience with intraoperative ECT of GM is discussed.
authors.affiliation: Division of Radiation Oncology, University of Nebraska College of Medicine, Omaha 68105.
authors.forename: P P
authors.initials: PP
authors.lastname: Kumar
authors.forename: R R
authors.initials: RR
authors.lastname: Good
authors.forename: E O
authors.initials: EO
authors.lastname: Jones
authors.forename: A A
authors.initials: AA
authors.lastname: Patil
authors.forename: L G
authors.initials: LG
authors.lastname: Leibrock
authors.forename: R D
authors.initials: RD
authors.lastname: McComb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005909:Glioblastoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D009329:Nebraska; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery; D011867:Radioisotope Teletherapy; D012086:Reoperation
chemical_list: D003037:Cobalt Radioisotopes