[A case of herpes zoster duplex with generalized eruption--study of the pathogenesis of the eruptions].
A 77-year-old man who developed herpes zoster duplex with generalized eruptions is presented. Three strains of varicella-zoster virus (VZV) were isolated from 2 skin lesions of herpes zoster and one of the generalized eruptions. For strain differentiation, these 3 strains were investigated by restriction endonuclease analysis of the viral DNA. The 3 strains were identical, suggested that a single strain of VZV had been residing in a latent form in multiple spinal ganglions of this patient. We speculate that this strain of VZV in remote ganglions was reactivated by the operation of gastric cancer as a trigger, and, as a result, the 2 skin lesions of herpes zoster appeared, followed by development of generalized eruptions due to virus propagation from zoster lesions.
Yoshida
M
M
Hondo
R
R
D000368:Aged; D004279:DNA, Viral / Q000032:analysis; D006562:Herpes Zoster / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D012867:Skin / Q000382:microbiology / Q000473:pathology*
D004279:DNA, Viral