[Effect of bilateral renal ischemia on the sodium, potassium ATPase activity of the kidneys and erythrocytes in rats].
The renovascular hypertension in the Wistar rats was induced by clipping both renal arteries. Within 3-4 weeks arterial pressure (AP) increased to maximal values. According to AP, the rats were divided into two groups: with AP less than or equal to 170 mm Hg and greater than 170 mm Hg. In 5-6 or 10-11 weeks the animals were decapitated and the Na,K-ATPase activities in the wholesome erythrocytes, their ghosts, and the cortex and medulla of kidneys were studied. Changes of the enzyme activity were only found in the medulla. A decreased enzyme activity (-20%) was revealed in the rats with AP less than or equal to 170 mm Hg within 5-6 weeks after renal ischemia, the activity increasing again in 10-11 weeks after the operation. The decreasing of Na,K-ATPase activity within 5-6 weeks after renal ischemia could be a mechanism of adaptation of the salt-water balance in animals.
Kazennov
A M
AM
Balashov
N V
NV
Rustamov
F A
FA
Soltitskiĭ
V V
VV
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology*; D007511:Ischemia / Q000201:enzymology*; D007668:Kidney / Q000098:blood supply* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D000254:Sodium-Potassium-Exchanging ATPase
Vliianie dvukhstoronneĭ ishemii pochek u krys na aktivnos't Na,K-ATFazy v pochkakh i éritrotsitakh.