Influence of 2,3-dimercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention.
2,3-Dimercaptosuccinic acid (DMSA) is a new orally active heavy metal chelator for the treatment of childhood Pb intoxication on an outpatient basis. The influence of DMSA, as well as other chelating agents, on gastrointestinal 203Pb absorption and whole-body 203Pb retention was examined. Groups of Sprague-Dawley rats (230-260 g) were gavaged with a solution containing approximately 25 mg/kg Pb [as Pb(NO3)2] plus 15 microCi 203Pb. Some groups were then immediately given 0.11 mmol/kg of either DMSA, CaNa2EDTA, D-penicillamine, or BAL by oral gavage, while other groups received the same drugs by ip injection. Control groups received solutions of the drug vehicles po or ip. Whole-body Pb retention and gastrointestinal Pb absorption (whole body retention + urinary Pb excretion) were significantly decreased in rats that received DMSA po. This finding implies that the use of DMSA to treat childhood lead intoxication on an outpatient basis is not associated with a risk for increased Pb absorption.
Kapoor
S C
SC
Department of Pharmacology, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
Wielopolski
L
L
Graziano
J H
JH
LoIacono
N J
NJ
D000284:Administration, Oral; D000818:Animals; D001822:Body Burden; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption / Q000187:drug effects*; D007854:Lead / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D004113:Succimer / Q000008:administration & dosage / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D007854:Lead; D004113:Succimer