Mechanism of innate immunity to amoebic infection in guineapigs.
The direct lymphocyte cytotoxicity and antibody dependent cell mediated cytotoxicity against Entamoeba histolytica was studied in 3-4 wk old and 8-10 wk old guineapigs. Both these parameters were significantly increased in splenic cells in the older animals. This might be due to maturation of the immune system or to natural infection by related parasite, leading to immunity.
Bhatti
H S
HS
Ganguly
N K
NK
Sehgal
R
R
Mahajan
R C
RC
D000375:Aging; D000562:Amebiasis / Q000276:immunology*; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D004748:Entamoeba histolytica / Q000276:immunology*; D006168:Guinea Pigs; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*