Responses of the three-toed sloth, Bradypus tridactylus, to some commonly used pharmacologic agents. II. Chloralose and reserpine.
1. Chloralose, 50 mg/kg i.v., is a safe effective anesthetic for sloths and reduces incidence of cardiac arrhythmias. 2. However, chloralose blocks baroreflexes and may reduce the sensitivity of beta 1 cardiac receptors. 3. Reserpine, 0.70 mg/kg given i.v. in divided doses, blocks the hypertensive effect of 100 micrograms/kg of tyramine in sloths. 4. Reserpine in this dosage materially reduces arterial pressure and heart rate; these effects last at least 7 days. 5. Reserpine potentiates the hypertensive effects of epinephrine and norepinephrine materially. 6. In sloths reserpine increases cardiac irritability but does not block baroreflexes. 7. As is true with most other drugs sloths are more sensitive to chloralose and reserpine than most common laboratory animals.
Duarte
D P
DP
Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Huggins
S E
SE
Da Costa
C P
CP
Leal
A M
AM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002698:Chloralose / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology*; D012896:Sloths; D004490:Xenarthra
D002698:Chloralose; D012110:Reserpine; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine