[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].
Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
Modesti
A
A
D'Orazi
G
G
Scarpa
S
S
Mezi
S
S
Gatti
F
F
Aloise
G
G
Gerace
D
D
Guglielmi
P
P
Simonelli
L
L
Modesti
M
M
D001943:Breast Neoplasms / Q000737:chemistry* / Q000648:ultrastructure*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry* / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis*; D005355:Fibrosis; D006801:Humans; D016253:Microscopy, Immunoelectron
D003094:Collagen
Studio ultrastrutturale ed immunoelettromicroscopico dello stroma desmoplastico nel carcinoma della mammella.