Plasma level and renal excretion of iotrolan after lumbar injection in patients.
Ten milliliters of iotrolan containing 240 mg I/ml were injected into the lower lumbar subarachnoid space of ten patients. Plasma level and urinary and fecal excretion were monitored for 3 days after injection. The mean iodine concentration in the plasma of about 50 micrograms/ml (6% of the dose given in the total plasma volume) peaked at 1 to 2 hours after injection. After reaching the maximum values, the iotrolan concentration in the plasma decreased with a half-life of about 4 hours (median value). About 90% of the injected dose was found in the urine and about 1% was detected in the feces.
Weinmann
H J
HJ
Vogelsang
H
H
Mützel
W
W
Speck
U
U
D000328:Adult; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007463:Iodobenzoates / Q000493:pharmacokinetics*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009192:Myelography; D014283:Triiodobenzoic Acids / Q000493:pharmacokinetics*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C033300:iotrolan