Central regulation of adrenal tyrosine hydroxylase: effect of induction on catecholamine levels in the adrenal medulla and plasma.
The effect of induction of adrenal tyrosine hydroxylase (TH) by various centrally acting drugs on catecholamine levels in adrenal and plasma was investigated in rats. All the drugs tested, namely oxotremorine, Piribedil, B-HT 920, and HA-966, produced significant increases in adrenal dopamine content and plasma epinephrine level. Denervation of the adrenal abolished the increase in adrenal dopamine as it did the induction of tyrosine hydroxylase. The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines.
Regunathan
S
S
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Missala
K
K
Sourkes
T L
TL
D000311:Adrenal Glands / Q000201:enzymology*; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001381:Azepines / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology; D004790:Enzyme Induction; D004837:Epinephrine / Q000097:blood / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D010095:Oxotremorine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010891:Piribedil / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*
D001286:Atropine Derivatives; D001381:Azepines; D015259:Dopamine Agents; D010276:Parasympatholytics; D011760:Pyrrolidinones; D010095:Oxotremorine; C024763:talipexole; C006649:methylatropine; D010891:Piribedil; D014446:Tyrosine 3-Monooxygenase; C001369:1-hydroxy-3-amino-2-pyrrolidone; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine