The human serum amyloid A (SAA)-encoding gene GSAA1: nucleotide sequence and possible autocrine-collagenase-inducer function.
We have determined the genomic sequence of the human GSAA1 gene, a member of the family of acute-phase human serum amyloid A (SAA)-encoding genes. This sequence predicts a mature protein of 104 amino acids (aa), several of which differ from residues usually conserved in the sequence of SAA proteins isolated from serum. Despite coding differences, however, the four-exon structure of GSAA1 resembles that of other SAA genes in humans and mice. The N-terminal 25 aa of the mature GSAA1 protein are virtually identical to those of an 'SAA-like' autocrine collagenase inducer produced by rabbit synovial fibroblasts; the latter also differ from the corresponding aa found in SAA in serum. We propose that GSAA1 is the human gene coding for a protein closely related to the SAA, but which is adapted to this important autocrine cytokine function.
Sack
G H
GH
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Talbot
C C
CC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001685:Biological Factors / Q000235:genetics; D016207:Cytokines; D004790:Enzyme Induction; D006801:Humans; D051379:Mice; D003012:Microbial Collagenase / Q000096:biosynthesis; D008969:Molecular Sequence Data; D011817:Rabbits; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D000685:Serum Amyloid A Protein / Q000235:genetics* / Q000502:physiology
D001685:Biological Factors; D016207:Cytokines; D000685:Serum Amyloid A Protein; D003012:Microbial Collagenase