Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.
To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.
Thompson
A J
AJ
Department of Neurology, London Hospital, UK.
Kennard
C
C
Swash
M
M
Summers
B
B
Yuill
G M
GM
Shepherd
D I
DI
Roche
S
S
Perkin
G D
GD
Loizou
L A
LA
Ferner
R
R
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012008:Recurrence
D000324:Adrenocorticotropic Hormone; D008775:Methylprednisolone