The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere.
The genetic defect responsible for Huntington disease was originally localized near the tip of the short arm of chromosome 4 by genetic linkage to the locus D4S10. Several markers closer to Huntington disease have since been isolated, but these all appear to be proximal to the defect. A physical map that extends from the most distal of these loci, D4S90, to the telomere of chromosome 4 was constructed. This map identifies at least two CpG islands as markers for Huntington disease candidate genes and places the most likely location of the Huntington disease defect remarkably close (within 325 kilobases) to the telomere.
Doggett
N A
NA
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Cheng
J F
JF
Smith
C L
CL
Cantor
C R
CR
D000818:Animals; D015139:Blotting, Southern; D002894:Chromosomes, Human, Pair 4; D006224:Cricetinae; D015342:DNA Probes; D004251:DNA Transposable Elements; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D006822:Hybrid Cells / Q000166:cytology; D010957:Plasmids; D015183:Restriction Mapping
D015342:DNA Probes; D004251:DNA Transposable Elements