The biosynthesis and actions of prostaglandins in the renal collecting tubule and thick ascending limb.
PGE2 formed by renal collecting tubules is an important factor in regulating NaCl and water reabsorption in the collecting tubule and medullary thick ascending limb. PGE2 appears to act, depending on its ambient concentration, via several different receptors present in these renal epithelia to modulate cAMP turnover in both positive and negative directions. These putative PGE receptors form a family of receptors, all coupled to G proteins, and this family of PGE receptors is homologous to the adrenergic receptor family.
Smith
W L
WL
Department of Biochemistry, Michigan State University, East Lansing 48824.
Sonnenburg
W K
WK
Allen
M L
ML
Watanabe
T
T
Zhu
J
J
el-Harith
E A
EA
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D008138:Loop of Henle / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism; D018078:Receptors, Prostaglandin E; D012965:Sodium Chloride / Q000378:metabolism
D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E; D012965:Sodium Chloride; D000242:Cyclic AMP; D015232:Dinoprostone