Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine.
Nephroblastomas were induced at an early age in two of six cynomolgus monkeys by prenatal exposure to 1,2-dimethylhydrazine. In one, the tumor of the right kidney had metastasized into the lower lobes of the lungs. By their histologic structure, development, and clinical course, the induced nephroblastomas were analogous to the Wilms' tumors often found in children.
Beniashvili
D S
DS
Oncological Research Center, Ministry of Health of the Georgian SSR, Tbilisi, USSR.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D004127:Dimethylhydrazines; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008252:Macaca fascicularis; D008297:Male; D008763:Methylhydrazines; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D009396:Wilms Tumor / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine