title: HLA-antigen distribution in seminoma, HCG-positive seminoma and non-seminomatous tumours of the testis.
abstract: Histocompatibility antigens play a certain role in the development of testicular tumours. 151 patients with testicular cancer (86 non-seminomatous germ cell tumours--NSGCT--and 65 pure seminoma) were typed for the HLA-antigens of the A, B, C and DR locus. 24 patients of the pure seminoma group and 50 patients of the NSGCT group had an elevated serum HCG level preoperatively. The antigen DR-5 was elevated in the seminoma group whereas the incidence of B-13 was increased in the NSGCT group. In terms of antigen distribution HCG-positive seminoma resembles seminomatous tumours rather than NSGCT.
authors.affiliation: Department of Urology, University of Vienna Medical School, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Kratzik
authors.forename: P
authors.initials: P
authors.lastname: Aiginger
authors.forename: R
authors.initials: R
authors.lastname: Kuzmits
authors.forename: J
authors.initials: J
authors.lastname: Spona
authors.forename: M
authors.initials: M
authors.lastname: Kirnbauer
authors.forename: A
authors.initials: A
authors.lastname: Seiser
authors.forename: W R
authors.initials: WR
authors.lastname: Mayr
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood*; D004407:Dysgerminoma / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology*
chemical_list: D006063:Chorionic Gonadotropin; D006680:HLA Antigens; D006684:HLA-DR Antigens