title: Prophylactic parenteral cefuroxime: subcutaneous concentrations in laparotomy wounds.
abstract: Plasma and subcutaneous adipose tissue cefuroxime concentrations were measured in laparotomy wounds, by means of high-pressure liquid chromatography, in 12 patients undergoing elective abdominal operations. After intravenous administration of 1.5 g cefuroxime at induction of anaesthesia, the measured concentrations in serum and wound tissue during a 2 h period were above the MIC 90 of most micro-organisms derived from the alimentary tract. Tissue peak levels were reached within 15 min and the tissue half life was 1.5 h.
authors.affiliation: Department of Surgery, King Edward VIII Hospital, Durban, South Africa.
authors.forename: W K
authors.initials: WK
authors.lastname: Huizinga
authors.forename: A
authors.initials: A
authors.lastname: Hirshberg
authors.forename: S R
authors.initials: SR
authors.lastname: Thomson
authors.forename: K I
authors.initials: KI
authors.lastname: Elson
authors.forename: R T
authors.initials: RT
authors.lastname: Salisbury
authors.forename: J G
authors.initials: JG
authors.lastname: Brock-Utne
mesh_terms: D000273:Adipose Tissue / Q000032:analysis*; D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis; D002444:Cefuroxime / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002511:Cephalosporins / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime