Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity.
Dahl-Puustinen
M L
ML
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
Dumont
E
E
Bertilsson
L
L
D000284:Administration, Oral; D000639:Amitriptyline / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009661:Nortriptyline / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism; D009928:Organ Specificity; D013237:Stereoisomerism
D005965:Glucuronates; C013567:10-hydroxynortriptyline; D000639:Amitriptyline; D009661:Nortriptyline