[Molecular genetic detection of polyclonal immune response in autoimmune thyroiditis and inflammatory bowel diseases].
Southern blot hybridization techniques were used to analyze the arrangements of the immunoglobulin and the T cell antigen receptor genes in lymphocytes of patients with Graves disease and Hashimoto's thyroiditis as well as in patients with Crohn's disease, chronic ulcerative colitis, and with other gastrointestinal disease. The results indicate that the immune response of autoimmune thyroid disease and inflammatory bowel disease is of polyclonal origin.
Kaulfersch
W
W
Universitäts-Kinderklinik Graz.
Baker
J R
JR
Burman
K D
KD
Fiocchi
C
C
Ahmann
A J
AJ
D'Avis
J C
JC
Waldmann
T A
TA
D000293:Adolescent; D000328:Adult; D015139:Blotting, Southern; D002648:Child; D003001:Cloning, Molecular; D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology*; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006111:Graves Disease / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013967:Thyroiditis, Autoimmune / Q000235:genetics / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell
Molekulargenetischer Nachweis einer polyklonalen Immunantwort bei Autoimmunthyreoiditis und entzündlichen Darmerkrankungen.