title: [Advantages of a cardiologic ambulatory care facility specifically organized for patients undergoing treatment with oral anticoagulant drugs].
abstract: In patients with artificial heart valve prosthesis oral anticoagulants reduce but not eliminate the thromboembolic complications however, they do increase the risk of bleeding. In the present study, the incidence of thromboembolic and hemorrhagic complications in two homogeneous groups of patients with artificial heart valves on long term oral anticoagulant treatment has been evaluated. Group A (99 patients; total follow-up = 309 years) were resident in the Triveneto regions and received a questionnaire while group B (104 patients; total follow-up = 370 years) were referred to our department's centre for the control of oral anticoagulant treatment. Both groups were kept at a therapeutic range of 20-30% in terms of prothrombin activity. The incidence of thromboembolic and hemorrhagic complications is expressed as the number of episodes per 100 patient/years. Thromboembolic episodes were 2.6 (1.3 fatal) in group A while they were 1.08 (0.27 fatal) in group B; the reduction of fatal thromboembolic events was statistically significant (p less than 0.05). Hemorrhagic episodes were 1.9 (0.63 fatal) in group A while they were 0.81 (0 fatal) in group B. We concluded that an organized control of oral anticoagulant treatment in patients with artificial heart valves is advantageous as it significantly reduces fatal thromboembolism. Moreover, it could reduce the incidence of total thromboembolic and hemorrhagic episodes by more than 50%.
authors.affiliation: Divisione e Cattedra di Cardiologia, Università degli Studi di Padova.
authors.forename: V
authors.initials: V
authors.lastname: Pengo
authors.forename: P
authors.initials: P
authors.lastname: Peruzzi
authors.forename: A
authors.initials: A
authors.lastname: Marzari
authors.forename: F
authors.initials: F
authors.lastname: Zanon
authors.forename: A
authors.initials: A
authors.lastname: Banzato
authors.forename: L
authors.initials: L
authors.lastname: Schivazappa
mesh_terms: D000284:Administration, Oral; D000359:Aftercare / Q000458:organization & administration*; D000553:Ambulatory Care / Q000458:organization & administration*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D013923:Thromboembolism / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants
vernacular_title: Vantaggi di un ambulatorio specifico organizzato da cardiologi per pazienti in trattamento con farmaci anticoagulanti orali.