[The membrane potential of the secretory cells of the mamma under the action of mezaton and izadrin].
The development of depolarization mesaton-induced and hyperpolarization isadrine-induced changes of the membrane potential of the mice mammary gland secretory cells was followed by a decrease in transepithelial electrical resistance and in potassium ions activity in the alveoli. The isadrine-induced hyperpolarization could be reversibly depressed by a substitution of chloride ions with sulphuric acid ions. Neither mesaton nor isadrine altered the MP after blocking of the Na+/K+ pump. Catecholamines seem to exert a direct alpha-adrenomimetic and an indirect beta-adrenomimetic reversible blocking effect upon the activity of the Na+/K+-ionic pump.
Tolkunov
Iu A
IuA
D000818:Animals; D004347:Drug Interactions; D004553:Electric Conductivity / Q000187:drug effects / Q000502:physiology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects / Q000502:physiology; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D010656:Phenylephrine / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology
D015221:Potassium Channels; D015222:Sodium Channels; D010656:Phenylephrine; D007545:Isoproterenol
Membrannyĭ potentsial sekretornykh kletok molochnoĭ zhelezy pri deĭstvii mezatona i izadrina.