Ketotifen does not inhibit asthmatic reactions induced by toluene di-isocyanate in sensitized subjects.
In order to determine whether treatment with ketotifen inhibits asthmatic reactions induced by toluene di-isocyanate (TDI), we studied six sensitized subjects with previously demonstrated dual or late asthmatic reaction after inhalation challenge with TDI. Ketotifen (1 mg b.i.d., orally) or placebo was administered for 7 days to the examined subjects, according to a double-blind, cross-over, placebo-controlled study design. When the subjects were treated with either ketotifen or placebo, FEV1 markedly decreased after exposure to TDI. These results suggest that the anti-asthmatic agent ketotifen is not effective in TDI-induced asthma and suggest that it should not be used in the prophylaxis of asthmatic reactions induced by TDI in sensitized subjects.
Tossin
L
L
Institute of Occupational Medicine, University of Padua, Italy.
Chiesura-Corona
P
P
Fabbri
L M
LM
De Marzo
N
N
Picotti
G
G
Crescioli
S
S
Mapp
C E
CE
D001249:Asthma / Q000139:chemically induced / Q000517:prevention & control*; D003485:Cyanates / Q000037:antagonists & inhibitors*; D004311:Double-Blind Method; D005541:Forced Expiratory Volume; D006801:Humans; D006968:Hypersensitivity, Delayed; D007114:Immunization; D007665:Ketotifen / Q000008:administration & dosage / Q000494:pharmacology*; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000276:immunology; D011897:Random Allocation; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects / Q000037:antagonists & inhibitors*
D003485:Cyanates; D008688:Methacholine Compounds; D016210:Methacholine Chloride; D014051:Toluene 2,4-Diisocyanate; D007665:Ketotifen