Enhancement of peripheral nerve regeneration by pharmacological activation of the cyclic AMP second messenger system.
This paper reviews the history of attempts to study peripheral nerve regeneration, focusing upon pharmacologic agents that may prove to be useful clinically. In particular, forskolin is described as a model for such an agent, and its mechanism of action, as a stimulator of the cyclic AMP second messenger system, is described.
Klein
H W
HW
Department of Surgery, University of California School of Medicine, Davis.
Kilmer
S
S
Carlsen
R C
RC
D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D004357:Drug Synergism; D007545:Isoproterenol / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D015290:Second Messenger Systems / Q000187:drug effects*; D013268:Stimulation, Chemical
D005576:Colforsin; D000242:Cyclic AMP; D007545:Isoproterenol