Brief report: primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor.
A virus, isolated from peripheral blood lymphocytes of a patient 23 days after liver transplantation, was identified by negative contrast and thin-section electron microscopy, DNA hybridisation, and immunofluorescence as human herpesvirus 6 (HHV-6). The patient was seronegative for antibodies to HHV-6 before receiving the liver from a seropositive donor. Seroconversion for IgM and IgG antibodies occurred at the same time as the viraemia, indicating a primary response to HHV-6 infection that was probably acquired from the donor liver. The relationship of the infection to the patient's subsequent disease episodes is discussed.
Ward
K N
KN
Department of Pathology, University of Cambridge, England.
Gray
J J
JJ
Efstathiou
S
S
D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D015342:DNA Probes; D005260:Female; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D006566:Herpesviridae Infections / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008099:Liver / Q000276:immunology / Q000382:microbiology; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000209:etiology* / Q000382:microbiology; D012698:Serologic Tests
D000914:Antibodies, Viral; D015342:DNA Probes