Sympathetic control of specific and non-specific immune response.
Following antigenic stimulation with specific (alloantigen) and non-specific (sheep red blood cells (SRBC) and lipopolysaccharide (LPS] antigens the expression of beta-adrenergic receptors and the interference of immune sera IgG, on uterine smooth muscle beta-adrenoceptor-specific ligands were studied. The binding of alloimmune IgG to beta-adrenoceptors appeared to be specific, because immunization with SRBC and LPS did not induce anti-beta-adrenoceptors antibodies. On the contrary, the decrease in beta-adrenergic receptor expression was observed even with alloantigens and with the conventional antigenic challenge, suggesting that this phenomenon could be a non-specific immunoregulatory mechanism.
Sales
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ME
Centro de Estudios Farmacológicos y de Principios Naturales, CONICET, Buenos Aires, Argentina.
Sterin-Borda
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Borda
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D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001667:Binding, Competitive; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000378:metabolism; D066298:In Vitro Techniques; D007518:Isoantibodies / Q000378:metabolism; D051379:Mice; D015213:Neuroimmunomodulation / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000276:immunology / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000276:immunology*; D014599:Uterus / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D007074:Immunoglobulin G; D007518:Isoantibodies; D011943:Receptors, Adrenergic, beta