Infectious anemia caused by a parvovirus-like virus in Georgia broilers.
Pale chicks with necrotic dermatitis, small bursas of Fabricius (BFs), small thymuses, pale bone marrow, and watery blood were suspected of having parvovirus-like virus- (PVLV) associated disease. Histologic lesions included atrophy or hypoplasia of thymuses and BFs, and septic necrotizing clostridial dermatitis and hepatitis. Clostridium perfringens was cultured from skin and liver. A PVLV was isolated in a Marek's disease tumor cell line (MDCC-MSB1) culture and was identified by physicochemical, immunofluorescent, and morphologic features. This isolate was named GA-1 PVLV. Specific-antibody-negative chicks and embryos infected with heat- or chloroform-treated GA-1 PVLV developed anemia at the same rate. Control chicks never were anemic. This is the first isolation of PVLV from clinically ill chickens in the United States and the first report of PVLV-induced anemia in chickens in the Western Hemisphere.
Goodwin
M A
MA
Georgia Poultry Laboratory, Oakwood 30566.
Brown
J
J
Miller
S L
SL
Smeltzer
M A
MA
Steffens
W L
WL
Waltman
W D
WD
D000740:Anemia / Q000209:etiology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D005845:Georgia; D008854:Microscopy, Electron; D010321:Parvoviridae / Q000302:isolation & purification* / Q000648:ultrastructure; D010322:Parvoviridae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors