[Effect of dopamine on small-intestinal motility in sheep].
The receptors involved in dopamine effect on the motility of the ileum were studied. The experiments were carried out on 3 sheep with chronic fistulas of the ileum and rumen. The contractions of the fistulated parts of the alimentary tract were recorded by the balloon method. Dopamine infused intravenously at a rate 28-38 micrograms.kg-1.min-1 inhibited the motility of the ileum. Domperidone (0.4-0.8 mg.kg-1) did not abolish this inhibiting influence of dopamine. Dopamine infused after propranolol (0.5-0.7 mg.kg-1) inhibited the motility of the ileum, however administrated after phentolamine (0.6-0.8 mg.kg-1) did not change its movements. It has been concluded that dopamine inhibits the ileum motility in sheep through alpha-adrenergic receptors.
Cebrat
E
E
Katedra Fizjologii Zwierzat Wydziału Weterynaryjnego AR we Wrocławiu.
Wegrzyn
T
T
Zieba
D
D
Leroch
Z
Z
D000818:Animals; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010528:Peristalsis / Q000187:drug effects / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D012756:Sheep / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D004298:Dopamine
Wpływ dopaminy na motoryke jelita cienkiego u owiec.