[Regulation of Na,K-ATPase by synaptosomal factors and neurotransmitters].
The identical increase of Na, K-ATPase activity is caused by oxidated and reduced forms of noradrenaline, serotonin and dopamine through the synaptosomal activating factors. The synaptosomal inhibiting factor, orthovanadate and calcium ions independently inhibit Na, K-ATPase activity. The inhibition constant (Ki) for vanadate does not change in the presence of EDTA, whereas in the presence of synaptosomal factors regulating the Na, K-ATPase factors, noradrenaline causes drastic increase of Ki for vanadate. It has been concluded, that the data point to the existence of special regulating system of brain synaptosomal Na, K-ATPase.
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D000818:Animals; D001921:Brain / Q000201:enzymology; D004298:Dopamine / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013574:Synaptosomes / Q000201:enzymology / Q000378:metabolism*; D014638:Vanadates / Q000494:pharmacology
D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D012701:Serotonin; D014638:Vanadates; D004492:Edetic Acid; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine; D009638:Norepinephrine
Reguliatsiia Na, K-ATFazy sinaptosomal'nymi faktorami i neĭrotransmitterami.