Frontal decortication decreases the affinity of N-(1-[2-thienyl]cyclohexyl)[3H]piperidine binding to rat striatum.
Bilateral ablation or transection of the corticostriatal pathways of the rat caused a reduction in N-(1-[2-thienyl]cyclohexyl)[3H]piperidine ([3H]TCP) binding to the striatum at 5-7, but not 3 and 14-28, days postlesion with a persistent decrease in striatal glutamate content 3-28 days after the decortication. This reduction was found to be due to an increase in Kd without changes in Bmax of the [3H]TCP binding. The present findings suggest that interruption of striatal glutamatergic transmission following frontal decortication may produce a temporal reduction in the affinity of phencyclidine receptor in the striatum.
Yoshida
Y
Y
Division of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan.
Nishikawa
T
T
Tanii
Y
Y
Takahashi
K
K
D000818:Animals; D002541:Cerebral Decortication; D003342:Corpus Striatum / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism / Q000502:physiology*; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D008297:Male; D009434:Neural Pathways / Q000378:metabolism / Q000502:physiology; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017478:Receptors, Phencyclidine
D005971:Glutamates; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D018698:Glutamic Acid; C012058:tenocyclidine; D010622:Phencyclidine