DNA-DR typing shows HLA-DRw11 RFLPs are increased in frequency in both progressive systemic sclerosis and CREST variants of scleroderma.
DNA-DR typing of patients with both Progressive Systemic Sclerosis and CREST variants of Scleroderma has shown an increase in frequency of DRw11 RFLPs. The frequency of DQw7 was also increased in the patient groups, but this was due to linkage disequilibrium with DRw11.
Dunckley
H
H
John Curtin School of Medical Research, Australian National University, Canberra.
Jazwinska
E C
EC
Gatenby
P A
PA
Serjeantson
S W
SW
D004247:DNA / Q000032:analysis*; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D012595:Scleroderma, Systemic / Q000235:genetics*
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C080766:HLA-DR11 antigen; D004247:DNA