In vitro inhibition of methionine incorporation in the dorsal bodies of Helix aspersa by synthetic FMRFamide.
1. In in vitro conditions, synthetic FMRFamide was shown to inhibit the uptake of labelled methionine by the dorsal bodies (DB)-containing connective tissue of Helix aspersa. 2. This effect occurred at physiological concentrations and in a dose-dependent manner. 3. Among the different cell types of the explants, the DB cells preferentially incorporated the radioactive precursor. 4. These results suggest that FMRFamide plays a biological role in controlling the DB activity (protein synthesis) of Helix aspersa.
Griffond
B
B
Laboratoire de Zoologie et Embryologie, UA CNRS 040687, Faculté des Sciences, Besançon, France.
Mounzih
K
K
D000818:Animals; D001345:Autoradiography; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003238:Connective Tissue / Q000378:metabolism; D004702:Endocrine Glands / Q000378:metabolism*; D019835:FMRFamide; D006372:Helix, Snails / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism*; D009479:Neuropeptides / Q000494:pharmacology*
D009479:Neuropeptides; D019835:FMRFamide; D008715:Methionine