title: The trophic effects of gastrin on fundic neuroendocrine cells of the rat stomach.
abstract: The histomorphological effect of multidose administration of 6 mg/kg pentagastrin b.d. for 5 weeks, and 1000 mg/kg sodium bicarbonate b.d. for 13 weeks, on the rat fundic mucosa has been examined. Sodium bicarbonate induced a significant hypergastrinaemia (plasma gastrin concentrations were 370.5 pg/ml in the control versus 642.6 pg/ml in sodium bicarbonate-treated rats after 13 weeks, P less than 0.01). Both treatment regimens induced fundic neuroendocrine cell hyperplasia. The cellular proliferation that occurred following hypergastrinaemia of endogenous or exogenous origin suggests that systemic gastrin concentrations play a major role in the control of fundic neuroendocrine cell populations.
authors.affiliation: Toxicology Department, Sterling-Winthrop Research Centre, Alnwick, Northumberland, UK.
authors.forename: C T
authors.initials: CT
authors.lastname: Eason
authors.forename: A J
authors.initials: AJ
authors.lastname: Spencer
authors.forename: A
authors.initials: A
authors.lastname: Pattison
authors.forename: F W
authors.initials: FW
authors.lastname: Bonner
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D005748:Gastric Fundus / Q000166:cytology / Q000187:drug effects*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D005755:Gastrins / Q000494:pharmacology*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D015290:Second Messenger Systems / Q000187:drug effects; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D005755:Gastrins; D017693:Sodium Bicarbonate; D012964:Sodium; D010418:Pentagastrin