[The hepatic hemodynamic response to intra-arterial infusion of vasoactive agents--Part 1. Blood flow measurements in dogs].
The common hepatic arterial (CHA), portal venous (PV) and liver tissue (LT) blood flows were measured during continuous infusion of vasoactive agents to the celiac axis under the observation of systemic circulation. The infusions of Angiotensin II (AT) (0.05 microgram/kg/min) and Prostaglandin F2 alpha (PGF) (0.025-0.05 microgram/kg/min) reduced CHA and LT blood flow, but caused no remarkable change of PV blood flow. The infusions of AT (0.5 microgram/kg/min) and PGF (0.5 microgram/kg/min) caused a biphasic response in CHA blood flow: an initial decrease in CHA blood flow was followed by a marked increase in this parameter (p less than 0.05), while PV blood flow decreased, but LT blood flow remained unchanged. The infusion of PGF (1.0 microgram/kg/min) reduced all parameters of CHA, PV and LT blood flows. The infusion of Dibutyryl cyclic AMP (DBcAMP) (2.0 mg/kg/hr) increased all parameters of CHA, PV and LT blood flows. Preinfusion of DBcAMP weakened the primary effects of PGF (1.0 microgram/kg/min) infusion.
Motohashi
O
O
Kusano
S
S
Nakayama
S
S
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D015237:Dinoprost / Q000494:pharmacology*; D004285:Dogs; D007261:Infusions, Intra-Arterial; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male
D000804:Angiotensin II; D003994:Bucladesine; D015237:Dinoprost