Age dependent changes in metallothionein and accumulation of cadmium in horses.
1. Analysis of livers and kidneys from 28 horses for cadmium, zinc and metallothionein showed low cadmium content in liver. There was a gradual increase in cadmium content in kidney with age. 2. Metallothionein values varied with zinc content in the liver and with cadmium content in the kidney; copper values did not vary in either tissue. 3. Metallothionein was localized mainly in the cytoplasms in liver and kidney of horses by immunohistochemistry.
Jeffery
E H
EH
University of Illinois, Institute of Environmental Studies, Urbana 61801.
Noseworthy
R
R
Cherian
M G
MG
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004785:Environmental Pollutants / Q000378:metabolism; D006736:Horses / Q000378:metabolism*; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D004785:Environmental Pollutants; D002104:Cadmium; D003300:Copper; D008668:Metallothionein; D015032:Zinc