Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study.
The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
Paik
S
S
Medicine Branch, National Cancer Institute, Bethesda, Maryland.
Rosen
N
N
Jung
W
W
You
J M
JM
Lippman
M E
ME
Perdue
J F
JF
Yee
D
D
D002675:Child, Preschool; D005333:Fetus / Q000032:analysis; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D007668:Kidney / Q000032:analysis* / Q000254:growth & development; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis*; D012016:Reference Values; D013002:Somatomedins / Q000032:analysis*; D009396:Wilms Tumor / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D012333:RNA, Messenger; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II