title: Effect of structural variations of non-ionic surfactants on micellar properties and solubilization: surfactants with semi-polar hydrophobes.
abstract: Novel non-ionic surfactants have been synthesized in which a polar group (either an ether or a keto group) has been introduced into the hydrocarbon chain of an octadecylpolyoxyethylene glycol monoether (C18En) with an oxyethylene chain length, n, of 17-18 units. Light scattering studies have indicated aggregation numbers for these semi-polar surfactants in aqueous solution of between 55-65% of that of an unsubstituted octadecylpolyoxyethylene glycol monoether, C18E22. The solubilizing capacities of the semi-polar surfactant micelles for test compounds which were mainly solubilized at the polyoxyethylene/core interface were lower than those of C18E22 whilst solubilizates which exhibited a reasonable degree of solubility in both the interface and the micellar core showed an increased solubilization.
authors.affiliation: Department of Pharmacy, University of Manchester, UK.
authors.forename: D
authors.initials: D
authors.lastname: Attwood
authors.forename: P H
authors.initials: PH
authors.lastname: Elworthy
authors.forename: M J
authors.initials: MJ
authors.lastname: Lawrence
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003102:Colloids; D003720:Densitometry; D008823:Micelles; D012542:Scattering, Radiation; D012997:Solvents; D013501:Surface-Active Agents; D014783:Viscosity
chemical_list: D003102:Colloids; D008823:Micelles; D012997:Solvents; D013501:Surface-Active Agents