Pathology of spontaneous malignant fibrous histiocytoma in a Japanese white rabbit.
Spontaneous malignant fibrous histiocytoma (MFH) of the chest wall was found in a 10-year-old male Japanese white rabbit. Histologically, the MFH consisted mainly of areas of storiform, pleomorphic and myxoid patterns. Positive reactions for acid phosphatase (Ac-P), non-specific esterase (N-SE) and beta-glucuronidase (beta-GL) were demonstrated in fibroblast-like, histiocyte-like and giant cells. Moreover, a strongly positive fibronectin (FN) reaction was observed mainly in histiocyte-like and giant cells. In electron microscopy, tumor cells were composed morphologically of various types of cells such as fibroblast-like, histiocyte-like, undifferentiated and giant cells. This case was quite similar to those reported in man or other animals.
Yamamoto
H
H
Department of Pathology, Kohno Clinical Research Institute, Tokyo, Japan.
Fujishiro
K
K
D000818:Animals; D000830:Animals, Laboratory; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011817:Rabbits; D013899:Thoracic Neoplasms / Q000473:pathology / Q000662:veterinary*