The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma.
In lymphoid neoplasms, nonrandom cytogenetic abnormalities correlate with clinical, morphologic and immunophenotypic features. A subtype of non-Hodgkin's lymphoma, which expresses the Ki-1 antigen (CD30) and has distinct morphologic and clinical features, has recently been described. We now report the association of a reciprocal translocation involving the short arm of chromosome 2 (band p23) and the long arm of chromosome 5 (band q35), t(2;5)(p23;q35), with Ki-1 positive anaplastic large cell lymphoma. Rearrangement of the genes that are located at the breakpoints on chromosomes 2 and 5 may be a critical step in the pathogenesis of this lymphoma.
Le Beau
M M
MM
Department of Medicine, University of Chicago, Illinois 60637.
Bitter
M A
MA
Larson
R A
RA
Doane
L A
LA
Ellis
E D
ED
Franklin
W A
WA
Rubin
C M
CM
Kadin
M E
ME
Vardiman
J W
JW
D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017730:Ki-1 Antigen; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen