Unusual precipitins in pathological human sera.
In conducting double diffusion gel precipitation tests, unexpected, strong precipitation reactions were noticed between a serum originating from a renal graft recipient and many pathological human sera. The highest frequency of positive reactions were produced by sera of patients with infectious mononucleosis (83%), chronic Epstein-Barr virus infections (72%), rheumatoid arthritis (57%), lepromatous leprosy (57%), and AIDS (44%). The precipitin in these pathological sera was identified as an antibody of IgM variety and the precipitinogen in the transplantation serum was shown to be a thermostable component with beta-globulin mobility. No explanation of the nature of reactions observed can be given at present.
Kim
D S
DS
Department of Microbiology, School of Medicine, State University of New York, Buffalo.
Anthone
R
R
Anthone
S
S
Milgrom
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000276:immunology; D007244:Infectious Mononucleosis / Q000276:immunology*; D016030:Kidney Transplantation; D011234:Precipitins / Q000032:analysis*; D014412:Tumor Virus Infections / Q000276:immunology*
D007075:Immunoglobulin M; D011234:Precipitins