Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids.
The insulin-like growth factor I (IGF-1) mediates the actions of pituitary growth hormone in a variety of tissues. Its receptor (IGF1R) displays considerable structural similarity to the insulin receptor. In humans, the IGF1R gene has been mapped near FES, the cellular counterpart of the feline sarcoma virus transforming gene v-fes, at the q25-q26 region of human chromosome 15 (HSA15). Here, we report the mapping of mouse Igf1r to mouse chromosome 7 (MMU7) by somatic cell hybrid analysis. This result, along with the prior assignment of the loci for mitochondrial isocitrate dehydrogenase and FES to human chromosome 15 and mouse chromosome 7, suggest a conserved autosomal synteny group on the distal long arm of HSA15 and in the center of MMU7.
Sundaresan
S
S
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Francke
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U
D000818:Animals; D002874:Chromosome Mapping; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D007334:Insulin-Like Growth Factor I; D051379:Mice; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000235:genetics*; D017451:Receptors, Somatomedin; D013002:Somatomedins
D015342:DNA Probes; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; C052602:proto-oncogene protein c-fes-fps; D007334:Insulin-Like Growth Factor I; D011505:Protein-Tyrosine Kinases