title: Pathological findings of two types of lymphoid malignancy in sheep inoculated with bovine leukemia virus.
abstract: Different types of lymphoid malignancy were observed in two sheep inoculated with BLV-containing materials. Sheep 1 showed severe leukemic change in the peripheral blood and splenomegaly but lymphosarcoma in the lymph nodes was absent. Sheep 2 had lymphosarcoma in the lymph nodes and various organs. Neoplastic cells had B-cell marker in both cases and a few neoplastic cells contained intracytoplasmic IgM in sheep 2. It was presumed that B-cells might be transformed into neoplastic cells on the way of their differentiation. Some of neoplastic cells might have ability of immunoglobulin-production in sheep 2.
authors.forename: S
authors.initials: S
authors.lastname: Ishino
authors.forename: I
authors.initials: I
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Yoshino
authors.forename: H
authors.initials: H
authors.lastname: Sentsui
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Y
authors.initials: Y
authors.lastname: Kono
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D007075:Immunoglobulin M / Q000096:biosynthesis; D001909:Leukemia Virus, Bovine; D007942:Leukemia, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D012756:Sheep
chemical_list: D007075:Immunoglobulin M