Acute toxicity of combinations of sodium dichromate, sodium arsenate and copper sulphate in the rat.
1. The intraperitoneal treatment of adult male Wistar rats with various combinations of low doses of sodium dichromate (5 mg/kg), sodium arsenate (25 mg/kg) and copper sulphate (5.9 mg/kg) tended to counteract the inherent acute toxicity of each compound. 2. The co-administration of low doses of one or more of the test compounds with a high dose of sodium dichromate (35 mg/kg), sodium arsenate (90 mg/kg) or copper sulphate (23.5 mg/kg) resulted in a significant increase in acute toxicity in comparison with that produced by the administration of high doses of dichromate, arsenate or Cu2+ alone.
Mason
R W
RW
Toxicology Research Unit (Medical Research Council of New Zealand), University of Otago Medical School, Dunedin.
Edwards
I R
IR
D000818:Animals; D001149:Arsenates / Q000008:administration & dosage / Q000633:toxicity*; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002840:Chromates / Q000008:administration & dosage / Q000633:toxicity*; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D019327:Copper Sulfate; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001149:Arsenates; D002840:Chromates; D003300:Copper; C009277:sodium arsenate; D003404:Creatinine; C016104:sodium bichromate; D019327:Copper Sulfate; D001151:Arsenic