Effect of albuterol on oxygen uptake and Na+-K+ ATPase activity of jejunal epithelia and liver in chickens.
Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma nonesterified fatty acids than those fed the control diet. Oxygen uptake by liver and jejunal epithelial tissues were 25 and 26% greater for chickens fed the diet with albuterol than for those fed the control diet, respectively. No changes in Na+-K+ ATPase activity of both liver and jejunal epithelia were detected as a result of feeding albuterol. These findings indicate that certain beta-agonists may elevate thermogenesis in chickens as a result of increasing metabolic rates of splanchnic tissues. However, the changes resulting in altering oxygen uptake in liver and jejunal epithelia due to feeding albuterol were not associated with Na+-K+ ATPase activity.
Rompala
R E
RE
Department of Animal Science, University of Connecticut, Storrs 06268.
Darre
M J
MJ
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004032:Diet; D005230:Fatty Acids, Nonesterified / Q000097:blood; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D000254:Sodium-Potassium-Exchanging ATPase; D000420:Albuterol