[Species and functional differences in NMDA receptors].
N-methyl-DL-aspartate induced in mice and rats hyperactivity and convulsions. In the mice convulsions effectively suppressed by selected antagonists of NMDA receptors AP 5 and AP 7, and also diazepam and ketamine. But hyperactivity very little attenuated by these substances in high doses. In the rats all these substances on the contrary suppressed hyperactivity and convulsions in the same degree. In the rats hynurenic acid prevented hyperactivity and convulsions. Observations point out to the fact that in mice there are two pharmacological and functional types of NMDA receptors whereas in rats there is only one type which is different from NMDA mice receptors.
Grigor'ev
V V
VV
Nemanova
V A
VA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006948:Hyperkinesis / Q000139:chemically induced / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D051379:Mice; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013045:Species Specificity
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter
Vidovye i funktsional'nye razlichiia NMDA-retseptorov.