title: Mechanism of induction of long term potentiation by the mast cell degranulating peptide.
abstract: The properties of Long Term Potentiation (LTP), which is a sustained enhancement of the synaptic response produced by a brief train of electrical stimulation, and its mechanisms are briefly reviewed. Bath application of the mast cell degranulating peptide (MCD) - a peptide isolated from bee venom- also produces in hippocampal slices LTP which is indistinguishable from that produced by a train of electrical stimulation (no change in postsynaptic cell properties, APV sensitive). In vivo push-pull experiments indicate that this LTP is not associated with a sustained enhancement of release of glutamate and aspartate, the two principle transmitters of the hippocampus, but there is a delayed enhanced release of proteins in the extracellular space which may contribute to the maintenance of the potentiation.
authors.affiliation: Inserm U 29, Hôpital de Port-Royal, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Ben Ari
authors.forename: E
authors.initials: E
authors.lastname: Cherubini
authors.forename: L
authors.initials: L
authors.lastname: Aniksztejn
authors.forename: M P
authors.initials: MP
authors.lastname: Roisin
authors.forename: C
authors.initials: C
authors.lastname: Charriaut-Marlangue
mesh_terms: D004558:Electric Stimulation; D006801:Humans; D010455:Peptides / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D010455:Peptides; C008331:mast cell degranulating peptide