Regulation of thymidine kinase activity in mouse L cells biochemically transformed by varicella-zoster virus.
Regulation of thymidine kinase (TK) activity was examined in L(O)c133 and L(H3) cells carrying varicella-zoster virus-TK gene. TK activity of L(O)c133 cells was similarly high in either medium but that of L(H3) cells was high in HAT medium and low in non-HAT medium. Cell growth was well correlated with TK activities of L(O)c133 and L(H3) cells in medium conditions. Regulation of the TK gene in L cells carrying the VZV-TK gene is discussed.
Shiraki
K
K
Department of Virology, Osaka University.
Mori
H
H
Hayakawa
Y
Y
Yamanishi
K
K
Takahashi
M
M
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002472:Cell Transformation, Viral; D003470:Culture Media; D005796:Genes; D005814:Genes, Viral; D014645:Herpesvirus 3, Human / Q000201:enzymology / Q000235:genetics*; D007700:Kinetics; D007739:L Cells / Q000166:cytology / Q000201:enzymology; D051379:Mice; D013937:Thymidine Kinase / Q000235:genetics* / Q000378:metabolism
D003470:Culture Media; D013937:Thymidine Kinase