title: Ethanol suppresses hippocampal cell firing through a calcium and cyclic AMP-sensitive mechanism.
abstract: The effects of ethanol were studied intracellularly in hippocampal pyramidal cells in vitro. Ethanol, 50-100 mM, produced a marked suppression of neuronal firing. This effect was blocked by treating the cell with cyclic 3', 5'-adenosine monophosphate (cAMP) or cadmium ions. Ethanol had no effect on the after-hyperpolarizing current. It is concluded that the ethanol-induced reduction of firing rate is due to a calcium-dependent process, and modulated by cAMP.
authors.affiliation: Department of Psychiatry, Bronx VA Medical Center, NY 10468.
authors.forename: D M
authors.initials: DM
authors.lastname: Benson
authors.forename: R D
authors.initials: RD
authors.lastname: Blitzer
authors.forename: E M
authors.initials: EM
authors.lastname: Landau
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D008566:Membranes / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology
chemical_list: D015124:8-Bromo Cyclic Adenosine Monophosphate; D000431:Ethanol; D011189:Potassium Chloride; D000242:Cyclic AMP; D002118:Calcium