[Adaptation to stress increases the resistance of isolated heart to damaging effects of Ca2+ due to optimization of Ca pump function in the sarcoplasmic reticulum].
The adaptation of rats to repeated short-term immobilization stress prevents the calcium-induced arrhythmias and contracture on isolated heart. Obtained results indicate, that main role in this effect plays an increase of both Ca-transport efficiency in sarcoplasmic reticulum and its resistance to autolytic processes.
Meerson
F Z
FZ
Sazontova
T G
TG
Malyshev
I Iu
IIu
D000222:Adaptation, Physiological; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D006321:Heart / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D013312:Stress, Physiological / Q000503:physiopathology*
D015220:Calcium Channels; D002118:Calcium
Adaptatsiia k stressornym vozdeĭstviiam povyshaet ustoĭchivost' izolirovannogo serdtsa k povrezhdaiushchim éffektam Ca2+ za schet optimizatsii raboty Ca-nasosa sarkoplazmaticheskogo retikuluma.