title: Urinary elimination half-life of delta-1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking.
abstract: The urinary excretion of delta 1-tetrahydrocannabinol-7-oic acid (delta 1-THC-7-oic acid), the major urinary metabolite of delta 1-THC, and the total amount of THC metabolites was studied in heavy marijuana users after smoking using high-performance liquid chromatography and the EMT-d.a.u. cannabinoid assay. An average elimination half-life (+/- SD) of 3.0 +/- 2.3 days was obtained for delta 1-THC-7-oic acid. The average ratio (+/- SD) of "EMIT readings"/delta 1-THC-7-oic acid concentrations was 1.23 +/- 1.03.
authors.affiliation: Department of Pharmacognosy, BMC, Uppsala, Sweden.
authors.forename: E K
authors.initials: EK
authors.lastname: Johansson
authors.forename: L E
authors.initials: LE
authors.lastname: Hollister
authors.forename: M M
authors.initials: MM
authors.lastname: Halldin
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D002189:Marijuana Abuse / Q000652:urine*; D008385:Marijuana Smoking / Q000652:urine*; D015813:Substance Abuse Detection / Q000379:methods*
chemical_list: C016780:11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; D013759:Dronabinol