Viral etiology of cervical carcinoma. Human papilloma virus and herpes simplex virus type 2.
The possible role of human papilloma virus (HPV) and herpes simplex virus type 2 (HSV-2) in the viral etiology of cervical carcinoma was investigated a series of cervical lesions were studied for the presence of HPV and HSV-2 DNA sequences as well as HPV and HSV-2 antigens by DNA dot blot hybridization technique and high-specificity PAP staining method. The results obtained were correlated with the histologic diagnosis. HPV 16 DNA sequences detected in cervical carcinoma biopsies were 43%, whereas HSV-2 DNA sequences were only 8%. HPV antigens detected in cervical dysplasia were 31%, whereas those detected in cervical carcinoma and cervicitis were the least. HSV-2 antigens were detected in chronic cervicitis, dysplasia and cervical carcinoma. The difference in positive rate between the cervical carcinoma and cervicitis groups was statistically significant, (chi-square test, P less than 0.01). No HPV DNA and HSV-2 DNA sequences were found in the same specimen, although both HPV DNA sequences and HSV-2 antigens were found in the same sample in some cases. The results indicate that the viral etiology of cervical carcinoma may be multifactorial. Both HSV-2 and HPV may be associated with cervical carcinoma, but the mechanisms involved are different. HSV-2 and HPV may act synergistically in the development of cervical carcinoma.
Meng
X J
XJ
Sun
Y
Y
Chen
M H
MH
Liu
Z H
ZH
Zhang
Y X
YX
Li
X Z
XZ
Li
K
K
Han
R C
RC
Si
J Y
JY
Hu
L Y
LY
D000957:Antigens, Viral, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000382:microbiology; D002584:Cervix Uteri / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000382:microbiology
D000957:Antigens, Viral, Tumor; D004279:DNA, Viral