Ligands specific to peripheral benzodiazepine receptors for treatment of porphyrias.
Accumulating data indicate that porphyrins are physiologically endogenous ligands to mitochondrial peripheral benzodiazepine receptors. An isoquinoline carboxamide derivative that likewise binds to peripheral benzodiazepine receptors could prove therapeutically useful in porphyrias by displacing porphyrins from these receptors in mitochondria.
Katz
Y
Y
Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel.
Weizman
A
A
Gavish
M
M
D006801:Humans; D007546:Isoquinolines / Q000378:metabolism / Q000627:therapeutic use*; D008024:Ligands; D008928:Mitochondria / Q000378:metabolism*; D009928:Organ Specificity; D011164:Porphyrias / Q000188:drug therapy* / Q000378:metabolism; D011166:Porphyrins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism
D007546:Isoquinolines; D008024:Ligands; D011166:Porphyrins; D011963:Receptors, GABA-A; C037850:PK 11195