An ultrastructural study of dynorphin-immunoreactive nerve fibers and terminals in the celiac-superior mesenteric ganglion of the guinea pig.
Dynorphin-immunoreactive nerve fibers and terminals were identified in the celiac-superior mesenteric ganglion of the guinea pig at the ultrastructural level with the peroxidase-antiperoxidase technique. The immunostained material was localized in the large dense core vesicles of the terminals but was also present diffusely in the axoplasm. The terminals formed numerous axodendritic and a few axosomatic contacts, interpreted as synapses, with the principal ganglion cells. These findings suggest that dynorphin plays a role as a neurotransmitter or neuromodulator in the ganglion and, taken together with earlier findings, indicate an involvement of dynorphin neurons in the intestino-intestinal inhibitory reflex.
Elfvin
L G
LG
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Lindh
B
B
Hökfelt
T
T
Terenius
L
L
D000818:Animals; D004399:Dynorphins / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000378:metabolism* / Q000648:ultrastructure; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D008643:Mesentery / Q000294:innervation* / Q000648:ultrastructure; D008854:Microscopy, Electron
D004399:Dynorphins