[Determination of potential carcinogenicity of nickel-containing dust using a micronuclear test].
Mutagenic activity of 3 samples of nickel-containing dusts was experimentally studied in white random-bred rats. Quantity of micronuclei in polychromatophilic erythrocytes of bone marrow smear depended on nickel dust content. Micronuclear test could be used as a rapid method for the determination of potential carcinogenic activity of polymetallic nickel-containing dusts and also as a factor confirming oncologic hazard of chemical substances combined with epidemiologic studies and chronic experiment on animals.
Kiseleva
A A
AA
Lipatov
G Ia
GIa
Pylev
L N
LN
Beresneva
O Iu
OIu
D000818:Animals; D015197:Carcinogenicity Tests; D003035:Cobalt / Q000032:analysis; D003300:Copper / Q000032:analysis; D004391:Dust / Q000032:analysis; D007501:Iron / Q000032:analysis; D015162:Micronucleus Tests; D009532:Nickel / Q000032:analysis; D051381:Rats; D012822:Silicon Dioxide / Q000032:analysis
D004391:Dust; D003035:Cobalt; D012822:Silicon Dioxide; D003300:Copper; D009532:Nickel; D007501:Iron
Opredelenie potentsial'noĭ kantserogennosti nikel'soderzhashchikh pyleĭ s pomoshch'iu mikroiadernogo testa.