Cholesterol metabolism in infant rats, effect of 6-hydroxydopamine and guanfacine.
Infant rats (10-16 days) and weaned animals (older than 18 days) were treated with drugs inhibiting beta-adrenergic activity and were sacrificed 4 days later. 6-Hydroxydopamine acts on postsympathetic nerve fibres, and guanfacine stimulates alpha 2-receptors. Both drugs caused a rise in plasma cholesterol and a decrease in hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in infant but not in weaned animals. The activity of acylcholesterol acyl CoA transferase, on the other hand, was decreased after drug administration. Thus, both antihypertensive drugs may cause changes in cholesterol metabolism, especially in infant animals.
Hahn
P
P
Department of Obstetrics, University of British Columbia, Vancouver, Canada.
Srubitski
L
L
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000320:Adrenergic Fibers / Q000187:drug effects; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D016316:Guanfacine; D006146:Guanidines / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D016627:Oxidopamine; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000187:drug effects*; D014886:Weaning
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D006146:Guanidines; D006892:Hydroxydopamines; D010648:Phenylacetates; D016316:Guanfacine; D016627:Oxidopamine; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase