title: Employment of magnet-susceptible microparticles for the targeting of drugs.
abstract: It has been demonstrated in cats that magnet-susceptible microspheres and liposomes containing neuromuscular blocking agents (dipyronium, pyrocurinum and diadonium) caused a deeper inhibition of the neuromuscular transmission in the limb placed in the magnetic field than in the control limb located beyond the field. The microparticles containing a short-acting neuromuscular blocking agent diadonium appeared to have the highest selectivity of action. The present method allows a pronounced neuromuscular block in a target area to be achieved without noticeable effect on PCO2 of the exhaled air.
authors.affiliation: Department of Pharmacology, First Medical Institute, Moscow, USSR.
authors.forename: D A
authors.initials: DA
authors.lastname: Kharkevich
authors.forename: R N
authors.initials: RN
authors.lastname: Alyautdin
authors.forename: V I
authors.initials: VI
authors.lastname: Filippov
mesh_terms: D000818:Animals; D002415:Cats; D004337:Drug Carriers; D004573:Electrolytes; D008081:Liposomes; D008280:Magnetics; D008863:Microspheres; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage
chemical_list: D004337:Drug Carriers; D004573:Electrolytes; D008081:Liposomes; D009466:Neuromuscular Blocking Agents