Inositol phosphates and cell signalling.
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
Berridge
M J
MJ
AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, UK.
Irvine
R F
RF
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D007295:Inositol Phosphates / Q000502:physiology*; D008094:Lithium / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000502:physiology*; D013403:Sugar Phosphates / Q000502:physiology*
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D013403:Sugar Phosphates; D008094:Lithium; D002118:Calcium