Cyanide poisoning successfully treated without 'therapeutic methemoglobin levels'.
A 24-year-old woman ingested an unknown amount of potassium cyanide in a suicide attempt. Coma and metabolic acidosis developed. Administration of the Lilly Cyanide Antidote kit (Eli Lilly and Co, Indianapolis) resulted in prompt resolution of symptoms and full recovery. Whole blood cyanide level was 13 micrograms/mL approximately one hour after ingestion. The highest measured methemoglobin level after sodium nitrite administration was 9.2%, demonstrating that attaining a "therapeutic methemoglobin level" of 25% is unnecessary to insure a satisfactory clinical outcome. Because severe hypotension or excessive methemoglobinemia can be caused by the sodium nitrite component of the Lilly kit, only enough to produce an acceptable clinical response should be administered.
Johnson
W S
WS
Department of Internal Medicine, Dakota Clinic, Ltd, Fargo, ND.
Hall
A H
AH
Rumack
B H
BH
D000138:Acidosis / Q000139:chemically induced / Q000188:drug therapy; D000328:Adult; D000680:Amyl Nitrite / Q000008:administration & dosage; D000931:Antidotes / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D003486:Cyanides / Q000506:poisoning*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008706:Methemoglobin / Q000032:analysis*; D011190:Potassium Cyanide / Q000097:blood / Q000506:poisoning*; D012977:Sodium Nitrite / Q000008:administration & dosage; D013406:Suicide, Attempted; D013885:Thiosulfates / Q000008:administration & dosage
D000931:Antidotes; D003486:Cyanides; D013885:Thiosulfates; D000680:Amyl Nitrite; D008706:Methemoglobin; C017717:sodium thiosulfate; D012977:Sodium Nitrite; D011190:Potassium Cyanide