Dual control over microvillus elongation during enterocyte development.
1. Previously determined logistic growth constants describing enterocyte microvillus development for a variety of species were analysed for possible interactions taking place between enterocyte migration rate (R) and the size of individual crypts (CD). 2. Microvillus elongation, the c-value of a logistic growth curve, was found to increase linearly with crypt depth and reciprocally with decreasing migration rate. The starting microvillus length of a basal crypt enterocyte, the a-value, also increased linearly with CD without being affected by R. 3. The mathematical equation describing the effects of CD and R on M, the maximal microvillus length, was M = 0.0016 CD + 0.073 CD/R, where M and CD are measured in micron and R in micron/hr. 4. The relationship found between R, CD and M is explained by suggesting that the crypt environment enables enterocytes to respond to an initiating signal imposed on cells as they begin to migrate onto villi. The possible nature of this putative signal is also discussed.
Smith
M W
MW
Agricultural Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
Brown
D
D
D000818:Animals; D002465:Cell Movement; D007413:Intestinal Mucosa / Q000166:cytology / Q000648:ultrastructure*; D008871:Microvilli / Q000502:physiology* / Q000648:ultrastructure; D008954:Models, Biological