Localization of GABAA receptor alpha-subunit mRNAs in relation to receptor subtypes.
The distribution of 3 GABAA receptor alpha-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the alpha 2- and alpha 3-transcripts are of low abundance in all regions except striatum, the alpha 1-transcript is considerably enriched in the inferior colliculus, olfactory bulb and substantia nigra, and appears to be correlated with benzodiazepine type I receptor localization.
Wisden
W
W
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
Morris
B J
BJ
Darlison
M G
MG
Hunt
S P
SP
Barnard
E A
EA
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D005786:Gene Expression Regulation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides; D012333:RNA, Messenger / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000145:classification / Q000378:metabolism*
D009841:Oligonucleotides; D012333:RNA, Messenger; D011963:Receptors, GABA-A