Inhibitory effect of pyrophosphate, citrate, magnesium and chondroitin sulphate in calcium oxalate urolithiasis.
The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone-forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.
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Department of Chemistry, University of the Balearic Islands, Palma de Mallorca, Spain.
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Conte
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March
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Costa-Bauzá
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D002129:Calcium Oxalate / Q000652:urine; D002807:Chondroitin; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D003460:Crystallization; D011756:Diphosphates / Q000627:therapeutic use*; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D014545:Urinary Calculi / Q000517:prevention & control* / Q000652:urine
D002951:Citrates; D011756:Diphosphates; D002129:Calcium Oxalate; D019343:Citric Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates; D008274:Magnesium; C003319:sodium pyrophosphate