[Microwave radiation treatment of liver cancer: animal experiment and preliminary clinical application].
Microwave radiation treatment of liver cancer in animals with microwave treatment apparatus (2450 MHz) in either a Single-antenna or 8-antenna (combined) radiator and its clinical use were reported. In laparotomy, the antenna was inserted into liver tissue or the hepatoma. The changes of liver pathology and ultra structure as well as the process of absorption and healing of radiated liver were investigated. The results showed that a large amount of air bubbles were formed in liver tissue and its small veins when the temperature was higher than 80 degrees C in the radiated center. These bubbles were drastically reduced in number when the temperature was controlled around 65 degrees C. The radiated liver was pathologically divided into three parts: necrosis area (the center of radiation), normal area (far from the center) and reactive area (between the necrosis and normal areas). The largest diameter of the coagulated area was about 5 cm. The coagulated tissue was completely absorbed 60 days after the operation. Seventeen cases of primary hepatoma and 8 cases of secondary liver cancers were treated with microwave radiation therapy with satisfactory results. The volume of bleeding during the operation was greatly reduced. No complication was found.
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D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D008114:Liver Neoplasms, Experimental / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats