title: Insulin-like growth factor (IGF)-I and IGF-binding activity in normal and fast-growing chickens.
abstract: Insulin-like growth factor(IGF)-binding activity were characterized in sera normal, fast growing, and very fast growing chicken strains. In contrast to a previous report, specific IGF-binding activity was observed in this nonmammalian species. Age-related IGF-binding activity levels did not differ between strains. IGF-I levels were significantly higher for the normal as compared to the 2 fast growing strains. Chromatographic studies show that IGF-I is associated with acid-dissociable high MW complexes in chicken serum, and the MW patterns are similar to human serum. Circulating levels of IGF-I or IGF-binding activity do not account for accelerated somatic growth in inbred large-bodied chicken strains.
authors.affiliation: Children's Hospital Kempe Research Center, Denver, CO.
authors.forename: P D
authors.initials: PD
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Peacock
authors.forename: M K
authors.initials: MK
authors.lastname: Roessler
authors.forename: J
authors.initials: J
authors.lastname: Hester
authors.forename: J T
authors.initials: JT
authors.lastname: Reeves
mesh_terms: D000375:Aging; D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000254:growth & development*; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000378:metabolism*; D017451:Receptors, Somatomedin; D012016:Reference Values; D013002:Somatomedins / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I