Immuno- and histochemical evidence for changed neurotransmission in basal forebrain, hippocampal formation and neocortex of aged rats.
The distribution of choline acetyltransferase- and gamma-aminobutyric acid-immunoreactivity as well as acetylcholinesterase-, gamma-aminobutyrci acid-transaminase- and monoaminooxidase-positive structures in the basal forebrain, hippocampal formation and neocortex of young adult and aged rats was compared. The changes in the staining and density of the immuno- and histochemical positive nerve cells and fibers observed provide evidence for the involvement of different transmitters in normal ageing.
Lolova
I
I
Davidoff
M
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007150:Immunohistochemistry; D008474:Medial Forebrain Bundle / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000502:physiology*