title: Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system.
abstract: We compared adrenocorticotropin-releasing activities of several interleukins in a homologous or heterologous in vivo system. Intravenous injection of rat interleukin-1 alpha significantly increased plasma adrenocorticotropin in conscious, freely-moving rats 30 min after the injection, and the effect was 10 times greater than that of human interleukin-1 alpha. Rat interleukin-2 affected plasma adrenocorticotropin in a much slower manner and increased its levels significantly 120 min after the injection. Human interleukin-2 had no effect on plasma adrenocorticotropin. Thus, species difference in the experimental system should be considered to assess the physiological significance of cytokines in the neuroendocrine system.
authors.affiliation: Department of Anesthesia, Kyoto University Faculty of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: J
authors.initials: J
authors.lastname: Fukata
authors.forename: T
authors.initials: T
authors.lastname: Tominaga
authors.forename: Y
authors.initials: Y
authors.lastname: Masui
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Imura
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D013329:Structure-Activity Relationship
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2; D011994:Recombinant Proteins; D000324:Adrenocorticotropic Hormone