Immune thrombocytopenia in dogs after fetal liver hematopoietic cell transplantation.
Immune thrombocytopenia occurred in 6 of 33 engrafted dogs (18%) after fetal liver hematopoietic cell transplantation. Concurrent granulocytopenia occurred in three of six dogs and anemia in one. All dogs were receiving cyclosporin to prevent graft rejection and graft-versus-host disease (GVHD). None of the dogs had signs of GVHD. Bone marrow obtained at the time of platelet nadir was hypercellular with megakaryocyte hyperplasia. All dogs exhibited anti-megakaryocyte antibodies detected by direct immunofluorescence of bone marrow smears. Treatment with oral prednisolone resulted in normalization of platelet counts in five of six dogs and granulocyte and erythrocyte counts in dogs exhibiting concurrent leukopenia or anemia. Two long-term survivors (greater than 2.5 years) have not developed further hematologic abnormalities since initial diagnosis and treatment.
Cain
G R
GR
Laboratory for Energy-Related Health Research, University of California, Davis 95616.
Champlin
R
R
Jain
N
N
D000818:Animals; D004285:Dogs; D005260:Female; D005333:Fetus; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D007958:Leukocyte Count; D016031:Liver Transplantation; D008297:Male; D009503:Neutropenia / Q000209:etiology; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000276:immunology*
D011239:Prednisolone