Reaction of trans-2-chlorovinylarsine oxide with polydeoxynucleotides.
Trans-2-chlorovinylarsine oxide (in DCl/acetone-d6) was added to various polydeoxynucleotides. The arsenical did react with poly[dG].poly[dC], releasing guanine, and resulting in a partial apurinic duplex.
Dill
K
K
Department of Chemistry, Clemson University, SC 29634-1905.
Adams
E R
ER
Davis
S D
SD
O'Connor
R J
RJ
McGown
E L
EL
Hallowell
S F
SF
D001152:Arsenicals / Q000378:metabolism*; D003854:Deoxyribonucleotides / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011067:Poly dA-dT / Q000378:metabolism; D011089:Polydeoxyribonucleotides / Q000378:metabolism; D011522:Protons
D001152:Arsenicals; D003854:Deoxyribonucleotides; D011089:Polydeoxyribonucleotides; D011522:Protons; C016681:poly(dG).poly(dC); D011067:Poly dA-dT; C019530:poly(dC-dG); C063691:2-chlorovinylarsine oxide