The structure and function of a mannose 6-phosphate receptor-enriched, pre-lysosomal compartment in animal cells.
The characteristics of a distinct prelysosomal compartment, evident in many animal cells, are described. The main feature of this compartment is that it is an acidic, tubulo-vesicular late endosome structure that contains high concentrations of the cation-independent mannose 6-phosphate receptor. The pathway to the lysosomes from the early endosomes, as well as that of newly synthesized lysosomal proteins from the trans-Golgi network, appear to converge in this prelysosomal compartment.
Griffiths
G
G
European Molecular Biology Laboratory, Heidelberg, FRG.
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis*; D002451:Cell Compartmentation / Q000502:physiology*; D002460:Cell Line; D008247:Lysosomes / Q000378:metabolism*; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000032:analysis*
D002352:Carrier Proteins; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface