Transdermal oestrogen for postmenopausal women: a double blind crossover comparative study with ethinyl oestradiol.
A double blind crossover study of transdermal oestradiol (50 micrograms/day) and ethinyl oestradiol (20 micrograms/day) was conducted with 25 postmenopausal women. Transdermal oestradiol increased circulating levels of oestradiol and oestrone. Both preparations favourably improved patients' symptoms and vaginal cytology, lowered gonadotrophin levels and urinary calcium loss and gave a satisfactory menstrual pattern. Transdermal oestradiol had no effect on measures of hepatic function whereas oral ethinyl oestradiol significantly altered levels of sex hormone binding globulin, plasma renin substrate and lipoproteins. Transdermal oestradiol has a comparable beneficial effect on postmenopausal symptoms to ethinyl oestradiol without the adverse effects on hepatic proteins.
Pattison
N S
NS
Department of Obstetrics and Gynaecology, University of Auckland, National Women's Hospital.
Uptin
T
T
Knox
B
B
France
J
J
D000279:Administration, Cutaneous; D000284:Administration, Oral; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood; D015914:Estrogen Replacement Therapy; D004970:Estrone / Q000097:blood; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D010349:Patient Compliance
D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol