title: Immunohistology of the skin rash associated with acute HIV infection.
abstract: An immunohistological study of the rash associated with acute HIV infection in a homosexual man was undertaken. The salient feature was an infiltrate of mononuclear cells predominantly of the CD4+ phenotype around the superficial dermal vessels. HIV p24 antigen was detected in occasional cells, possibly Langerhans' cells, of the infiltrate. Their presentation of HIV antigen to local CD4+ cells may lead to a delayed type hypersensitivity reaction.
authors.affiliation: Department of Medicine, University of Edinburgh, UK.
authors.forename: A
authors.initials: A
authors.lastname: McMillan
authors.forename: P E
authors.initials: PE
authors.lastname: Bishop
authors.forename: D
authors.initials: D
authors.lastname: Aw
authors.forename: J F
authors.initials: JF
authors.lastname: Peutherer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000208:Acute Disease; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006716:Homosexuality; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012191:Retroviridae Proteins / Q000032:analysis; D012867:Skin / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology
chemical_list: D015488:HIV Antigens; D016655:HIV Core Protein p24; D012191:Retroviridae Proteins