title: Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins.
abstract: This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.
authors.affiliation: School of Pharmacy, Department of Chemical Physics, University of Valencia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Garcia Domenech
authors.forename: O
authors.initials: O
authors.lastname: Abril Mendez
authors.forename: J
authors.initials: J
authors.lastname: Galvez Alvarez
authors.forename: A
authors.initials: A
authors.lastname: Farga Marti
mesh_terms: D001798:Blood Proteins; D004492:Edetic Acid; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011485:Protein Binding; D004113:Succimer; D013438:Sulfhydryl Compounds; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016284:Technetium Tc 99m Pentetate
chemical_list: D001798:Blood Proteins; D015609:Organotechnetium Compounds; D013438:Sulfhydryl Compounds; C039918:technetium Tc 99m EDTA; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004369:Pentetic Acid; D004492:Edetic Acid; D004113:Succimer; D016284:Technetium Tc 99m Pentetate