Effects of norakin on respiratory syncytial virus in tissue culture and in mice.
Norakin at 1 microgram/ml inhibits the reproduction of respiratory syncytial virus (RSV) in Vero cells to 50% and at 5 micrograms/ml to 90%. The development of lung lesions in RSV-infected BALB/c mice was suppressed by 70% when the animals were treated with two doses (25 mg/kg each) of norakin, 30 min before and 4 hr post infection. (p.i.), respectively.
Mentel
R
R
Institut für Medizinische Mikrobiologie, Ernst-Moritz-Arndt-Universität, Greifswald, DDR.
Schroeder
C
C
Döhner
L
L
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D011024:Pneumonia, Viral / Q000188:drug therapy; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000502:physiology; D010253:Respirovirus Infections / Q000188:drug therapy; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010880:Piperidines; C046667:triperiden