An evaluation of 6 dentifrice formulations for supragingival anticalculus and antiplaque activity.
A 4 week, double blind clinical trial was conducted to assess the antiplaque/anticalculus activity of test dentifrices containing varying levels of zinc citrate. Subjects were divided into 6 groups, 4 experimental, 1 positive control and a placebo group. All subjects only brushed at home using the placebo control during study weeks 1 and 3. Plaque and calculus were collected at the end of study weeks 2 and 4 on mylar strips worn on lower incisor teeth. Dentifrice efficacy was assessed by comparing group dry and ash weight decrements. While there were no significant differences between the test and control groups, there was a demonstrable trend toward greater inhibition with higher zinc citrate levels, especially among subjects with high levels of plaque and calculus at baseline.
Disney
J A
JA
University of North Carolina, Chapel Hill.
Graves
R C
RC
Cancro
L
L
Payonk
G
G
Stewart
P
P
D000537:Aluminum Oxide / Q000627:therapeutic use; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D002986:Clinical Trials as Topic; D003728:Dental Calculus / Q000517:prevention & control*; D003773:Dental Plaque / Q000032:analysis / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use; D012044:Regression Analysis; D012822:Silicon Dioxide / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use*
D002951:Citrates; D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; D019343:Citric Acid; D012822:Silicon Dioxide; D015032:Zinc; D000537:Aluminum Oxide; D005459:Fluorides