[Circadian variation of the nephrotoxicity induced in rats by bi-daily repeated administration of amikacin].
We have studied the chrononephrotoxicity of amikacin during and after a prolonged treatment in rats. Animals received by intramuscular route a daily dose of 400 mg/kg (in two times) during 7 days at two different times (8.00 - 20.00 and 14.00 - 2.00). Large time-dependent variations in renal injury had been evidenced by several parameters and particularly by enzymuria. This injury is maximal when administration is made at 14.00 - 2.00. These data confirmed our results obtained in previous investigations with single daily injections and evidence that chrononephrotoxicity could permit an optimization of nephrotoxic drugs largely used in clinics.
Dorian
C
C
Groupe d'Etude de Physiologie et Physiopathologie Rénales Faculté de Pharmacie, Bordeaux.
Catroux
P
P
Cambar
J
J
D000118:Acetylglucosaminidase / Q000652:urine; D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002940:Circadian Rhythm; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000652:urine
D000583:Amikacin; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase
Variations temporelles de la néphrotoxicité induite chez le rat par administration bi-quotidienne réitérée d'amikacine.