Spin-trapping studies with MTDO, a dihydroquinoline type radical scavenger.
The effect of MTDQ, a dihydroquinoline type free radical scavenger was studied in biological membranes, and model systems. Using spin-labelling and spin-trapping methods, it was that MTDQ induced a decrease of the mobility of spin labels attached to the thiol sites of membrane proteins, and it was a strong free radical scavenger in hydroxyl and superoxide anion free radical generating systems. The experimental results suggest that the presence of MTDQ in the cell membranes may improve the protection of membrane components against free radical attacks.
Belágyi
J
J
Central Laboratory, University School of Medicine, Pécs, Hungary.
Pótó
L
L
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006878:Hydroxides / Q000494:pharmacology; D017665:Hydroxyl Radical; D008566:Membranes / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D011893:Rana esculenta; D013113:Spin Labels
D005609:Free Radicals; D006878:Hydroxides; D011804:Quinolines; D013113:Spin Labels; D017665:Hydroxyl Radical; C011923:6,6'-methylene bis(2,2,4-trimethyl-1,2-dihydroquinoline)