An Eco RI polymorphic site in the human complement C4 gene distinguishes juvenile rheumatoid arthritis (JRA) susceptibility-bearing haplotypes.
Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards.
Arnaiz-Villena
A
A
Department of Immunology, Hospital 12 de Octubre, Madrid, Spain.
Vicario
J L
JL
Martinez-Laso
J
J
Corell
A
A
Regueiro
J R
JR
Gomez-Reino
J
J
Gomez-Reino
J
J
D001171:Arthritis, Juvenile / Q000235:genetics*; D001665:Binding Sites; D002648:Child; D003181:Complement C4 / Q000235:genetics*; D004198:Disease Susceptibility; D005796:Genes; D006684:HLA-DR Antigens; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D003181:Complement C4; D006684:HLA-DR Antigens