[The molecular bases of the pathogenesis of AIDS].
The comparative study of the amino acid sequence of gp120 in human immunodeficiency virus (HIV) strains HTLV-III and ARV-2 and the amino end areas of the growth hormone receptors of human skin and the insulin receptors has been carried out, thus making it possible to predict the existence of two compact domains connected with an area of a peptide chain. This area is incapable of the formation of a compact globular structure due to a high content of the remnants of proline. The data obtained as the result of electron microscopic study in combination with image processing have confirmed the predicted three-dimensional structure of gp120. This study has also shown that the amino acid sequence of some regions in the domains of gp120 has a significant degree of homology with similarly located regions of the growth hormone and insulin receptors; in its turn, this amino acid sequence is homologous to the framework regions of the VH domain of immunoglobulin. Antibodies to this VH domain specifically react with recombinant HTLV-III antigen. On the basis of the data obtained in our experiments and from the analysis clinico-immunological information, we have come to the conclusion that AIDS is an autoimmune disease induced by HIV due to the structural homology of gp120 with highly important receptors of human cells.
Kul'berg
A Ia
AIa
Bykovskiĭ
A F
AF
Pokrovskiĭ
V I
VI
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D000595:Amino Acid Sequence; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics / Q000382:microbiology; D015704:CD4 Antigens / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000648:ultrastructure; D015497:HIV-1 / Q000235:genetics / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D011972:Receptor, Insulin / Q000235:genetics / Q000648:ultrastructure; D015728:Receptors, HIV / Q000235:genetics / Q000648:ultrastructure; D011986:Receptors, Somatotropin / Q000235:genetics / Q000648:ultrastructure; D012689:Sequence Homology, Nucleic Acid
D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D015728:Receptors, HIV; D011986:Receptors, Somatotropin; D011972:Receptor, Insulin
Molekuliarnye osnovy patogeneza SPID.