Prevention of ischemic neuronal damage by alpha 1-adrenoceptor agonist (methoxamine).
The effect of methoxamine, an alpha 1-adrenoceptor agonist, on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of ischemia by bilateral common carotid arteries occlusion. Morphological changes and calcium accumulation were evaluated in the CA1 sector of the hippocampus after 7 days of survival. The degree of ischemic neuronal damage and calcium accumulation in the methoxamine-treated groups were significantly attenuated compared with the saline-treated ischemic group. The results suggest that alpha 1-adrenoceptor stimulation prevents ischemic neuronal damage.
Araki
T
T
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kogure
K
K
Izumiyama
K
K
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000818:Animals; D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008729:Methoxamine / Q000627:therapeutic use*
D000316:Adrenergic alpha-Agonists; D008729:Methoxamine