Impaired bioavailability of famotidine given concurrently with a potent antacid.
The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 +/- 22 to 104 +/- 7, P less than 0.05) and area under the famotidine plasma concentration curve (from 956 +/- 125 to 607 +/- 56, P less than 0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.
Barzaghi
N
N
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
Gatti
G
G
Crema
F
F
Perucca
E
E
D000284:Administration, Oral; D000328:Adult; D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology*; D001682:Biological Availability; D004347:Drug Interactions; D015738:Famotidine; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011897:Random Allocation; D013844:Thiazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D000863:Antacids; D006635:Histamine H2 Antagonists; D013844:Thiazoles; D015738:Famotidine