title: Seasonal rhythm of platelet 3H-imipramine binding in normal controls.
abstract: The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuated about a yearly mean of 2647.5 fmol/mg. The present results underscore the importance of including seasonally matched controls in the evaluation of potential patient differences in platelet binding.
authors.affiliation: Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
authors.forename: E M
authors.initials: EM
authors.lastname: DeMet
authors.forename: A
authors.initials: A
authors.lastname: Chicz-DeMet
authors.forename: J
authors.initials: J
authors.lastname: Fleischmann
mesh_terms: D000328:Adult; D001683:Biological Clocks; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012016:Reference Values; D012621:Seasons
chemical_list: D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine