Association between alcohol consumption and cancer of the sigmoid colon: observations from a Japanese cohort study.
A 17-year follow up of 265,118 Japanese adults aged 40 years and above revealed a close association between cancer of the sigmoid colon (n = 91) and alcohol consumption: relative risk (RR) for drinkers versus non drinkers was 4.38 (90% CI 1.75-10.97) in men and 1.92 (1.13-3.26) in women. In men, attributable risk was 74% and RRs in non, infrequent, occasional, and daily drinkers were 1.00, 2.03, 3.83, and 5.42, respectively. RRs of daily consumption versus non-consumption in men for cancers of mouth, pharynx, oesophagus, stomach, proximal colon, sigmoid colon, and rectum were 2.27, 2.44, 2.29, 0.92, 0.98, 5.42, and 1.39, respectively. A combined effect of alcohol and smoking was evident for cancers of the upper digestive tract but almost absent for those of the lower digestive tract.
Hirayama
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Institute of Preventive Oncology, Tokyo, Japan.
D000328:Adult; D000428:Alcohol Drinking; D015331:Cohort Studies; D004067:Digestive System Neoplasms / Q000150:complications / Q000401:mortality; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D012811:Sigmoid Neoplasms / Q000150:complications* / Q000401:mortality; D012907:Smoking / Q000009:adverse effects