Continuous infusion of high-dose acyclovir for serious herpesvirus infections.
Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.
Fletcher
C V
CV
Department of Pharmacy Practice, University of Minnesota, Health Sciences Center, Minneapolis 55455.
Englund
J A
JA
Bean
B
B
Chinnock
B
B
Brundage
D M
DM
Balfour
H H
HH
D000212:Acyclovir / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male
D000212:Acyclovir