[Modification of blood coagulation by antihypertensive therapy? Effect of enalapril and hydrochlorothiazide on blood coagulation parameters in patients with essential hypertension].
An increased tendency of the blood to clot in patients with arterial hypertension is not desirable, since cardiovascular and cerebrovascular sequelae may be aggravated. Recently, activation of coagulation under ACE inhibition with captopril has been described. In an open, randomized study, we compared the influence of enalapril on various coagulation parameters with that of hydrochlorothiazide. In contrast to the latter, we detected no unfavorable influence of enalapril on the coagulation factors investigated. A transient increase in fibrin monomeres was observed in one patient each on enalapril and hydrochlorothiazide.
Wichmann
C
C
Zähringer
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001780:Blood Coagulation Tests; D004656:Enalapril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D006852:Hydrochlorothiazide; D004656:Enalapril
Beeinflussung der Blutgerinnung durch antihypertensive Therapie? Wirkung von Enalapril und Hydrochlorothiazid auf Blutgerinnungsparameter bei Patienten mit essentieller Hypertonie.