title: Urinary enzyme output during detoxification of chronic alcoholic patients.
abstract: The urinary excretion of N-acetylglucosaminidase, gamma-glutamyl transferase and lactate dehydrogenase was elevated by two to three fold in chronic alcoholic patients when compared to normal controls. After 4 weeks of alcohol abstention, the urinary excretion of these enzymes returned to control values. Increased urinary enzyme excretion was not related to malnutrition or pathological glomerular filtration and is due most probably to a direct effect of alcohol on the renal proximal tubule.
authors.affiliation: Gastroenterology Unit, Royal Liverpool Teaching Hospital, U.K.
authors.forename: D
authors.initials: D
authors.lastname: Martines
authors.forename: A I
authors.initials: AI
authors.lastname: Morris
authors.forename: I T
authors.initials: IT
authors.lastname: Gilmore
authors.forename: M A
authors.initials: MA
authors.lastname: Ansari
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: J A
authors.initials: JA
authors.lastname: Quayle
authors.forename: D
authors.initials: D
authors.lastname: Billington
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000437:Alcoholism / Q000201:enzymology / Q000534:rehabilitation*; D003404:Creatinine / Q000652:urine; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000652:urine*; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000652:urine*
chemical_list: D007527:Isoenzymes; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase