title: Clinical characterization of non-small-cell lung cancer tumors showing neuroendocrine differentiation features.
abstract: In most cases of small-cell lung carcinomas (SCLC) phenotypic features compatible with a neuroendocrine differentiation status can be identified by monoclonal (MOC) antibody-based immunohistological procedures. Similar features can be recognized only in a minority of non-SCLC tumors. During a period of 30 months, all diagnostic non-SCLC biopsies (141 cases) were prospectively analysed for the presence of markers indicative for neuroendocrine differentiation. In 31% of all cases, such a presence could be noticed. Neuroendocrine differentiation (50% to 100% positive-staining tumor cells) was recognized more frequently in adenocarcinoma when compared to large-cell and squamous-cell carcinoma (chi 2 = 9.31, 2 degrees of freedom, P less than 0.01). To investigate whether the clinical behavior of these "neuroendocrine" non-SCLC cases mimics SCLC, a multivariate analysis for prognostic factors was performed. Among other prognostic factors, biopsies containing more than 50% positive-staining tumor cells with the MOC antibody-1 (MOC-1) were recognized as negative prognostic factors.
authors.affiliation: Department of Clinical Immunology, University Hospital, Groningen, The Netherlands.
authors.forename: H H
authors.initials: HH
authors.lastname: Berendsen
authors.forename: L
authors.initials: L
authors.lastname: de Leij
authors.forename: S
authors.initials: S
authors.lastname: Poppema
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
authors.forename: A
authors.initials: A
authors.lastname: Boes
authors.forename: H J
authors.initials: HJ
authors.lastname: Sluiter
authors.forename: H
authors.initials: H
authors.lastname: The
mesh_terms: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000276:immunology / Q000473:pathology; D015999:Multivariate Analysis; D011379:Prognosis; D012044:Regression Analysis; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm