Decreased phosphofructokinase activity during the development of triorthocresyl-phosphate-induced delayed neuropathy.
The effect of triorthocresyl phosphate on selected glycolytic enzymes (hexokinase, phosphofructokinase, glyceraldehyde 3-phosphate dehydrogenase, lactate dehydrogenase) was investigated during the development of organophosphate-induced delayed neuropathy. Only phosphofructokinase activity was decreased 15 days after treatment. The effect was dose-dependent and was observed in sciatic nerve while the brain enzyme activity was not affected.
Hernandez
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AF
Department of Legal Medicine and Toxicology Service, Faculty of Medicine, University Hospital, University of Granada, Spain.
Pla
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A
Villanueva
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E
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002802:Cholinesterases / Q000097:blood; D003408:Cresols / Q000633:toxicity*; D005260:Female; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D011200:Poultry; D012584:Sciatic Nerve / Q000187:drug effects / Q000201:enzymology; D014317:Tritolyl Phosphates / Q000633:toxicity*
D003408:Cresols; D014317:Tritolyl Phosphates; D007770:L-Lactate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D006593:Hexokinase; D010732:Phosphofructokinase-1; D002802:Cholinesterases; C025541:tri-o-cresyl phosphate