Suppression of the lethal effect of acidic-phospholipid deficiency by defective formation of the major outer membrane lipoprotein in Escherichia coli.
The Escherichia coli pgsA3 allele encoding a defective phosphatidylglycerophosphate synthase is lethal for all but certain strains. Genetic analysis of such strains has revealed that the lethal effect is fully suppressed by the lack of the major outer membrane lipoprotein that consumes phosphatidylglycerol for its maturation.
Asai
Y
Y
Department of Biochemistry, Saitama University, Urawa, Japan.
Katayose
Y
Y
Hikita
C
C
Ohta
A
A
Shibuya
I
I
D000483:Alleles; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development; D005798:Genes, Bacterial; D005838:Genotype; D008074:Lipoproteins / Q000096:biosynthesis*; D009154:Mutation; D010770:Phosphotransferases / Q000235:genetics*; D013489:Suppression, Genetic; D017855:Transferases (Other Substituted Phosphate Groups)
D008074:Lipoproteins; D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C020676:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase