Presynaptic effects of spider toxins: increase of high affinity uptake in the arthropod peripheral glutamatergic system.
In contrast to the reported effects of polyamines on the high affinity neurotransmitter uptake, two polyamine-like spider toxins significantly increase the high affinity uptake of glutamate as demonstrated with high resolution autoradiography. The effects of both spider toxins were compared to those of a polyamine toxin from the wasp Philanthus triangulum, which is known to inhibit the high affinity glutamate uptake.
van Marle
J
J
Department of Electron Microscopy, University of Amsterdam, The Netherlands.
Piek
T
T
Karst
H
H
Lind
A
A
van Weeren-Kramer
J
J
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D001345:Autoradiography; D001369:Axons / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006110:Grasshoppers / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000294:innervation; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D013111:Spider Venoms / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D001180:Arthropod Venoms; D005971:Glutamates; D013111:Spider Venoms; D018698:Glutamic Acid