title: Transient low-threshold Ca2+ current triggers burst firing through an afterdepolarizing potential in an adult mammalian neuron.
abstract: In a variety of mammalian neurons, a brief depolarization generates an afterdepolarizing potential that triggers the firing of a short series or burst of action potentials. Although such burst firing is thought to contribute to the processing of neural information, the ionic currents that underlie this phenomenon have not been established. In whole-cell patch-clamp experiments on dorsal root ganglion neurons, we have found that the current that underlies this type of burst firing is a transient low-threshold (T-type) Ca2+ current. The data suggest that the T-type Ca2+ current may play an important role in the processing of information in the nervous system by virtue of its ability to elicit burst firing in neurons.
authors.affiliation: Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
authors.forename: G
authors.initials: G
authors.lastname: White
authors.forename: D M
authors.initials: DM
authors.lastname: Lovinger
authors.forename: F F
authors.initials: FF
authors.lastname: Weight
mesh_terms: D000200:Action Potentials; D000818:Animals; D001464:Barium / Q000494:pharmacology; D002104:Cadmium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002413:Cations, Divalent; D002712:Chlorides / Q000494:pharmacology; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D009532:Nickel / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology
chemical_list: D015220:Calcium Channels; D002413:Cations, Divalent; D002712:Chlorides; D002104:Cadmium; D001464:Barium; D009532:Nickel; D012964:Sodium; D002118:Calcium