Structure and expression of an integrated human papillomavirus type 16 genome amplified in a cervical carcinoma cell line.
A cellular sequence containing the integrated human papillomavirus type 16 genome in a cervical carcinoma cell line QG-U was cloned and analysed. The transcriptionally active viral genome disrupted at the E2 and L2 open reading frames was amplified with its flanking sequences.
Shirasawa
H
H
Department of Microbiology, School of Medicine, Chiba University, Japan.
Tomita
Y
Y
Fuse
A
A
Yamamoto
T
T
Tanzawa
H
H
Sekiya
S
S
Takamizawa
H
H
Simizu
B
B
D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics / Q000382:microbiology*; D002460:Cell Line; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005784:Gene Amplification; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics*; D015183:Restriction Mapping; D014158:Transcription, Genetic; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000382:microbiology*
D015344:DNA Probes, HPV; D004279:DNA, Viral