FIA determination of chlorhexidine by means of the precipitation with Cu(II).
The determination of chlorhexidine in pharmaceutical formulations is carried out using flow injection analysis (FIA) with measurement by atomic absorption spectrometry (AAS). The method is based on the formation of a copper-biguanide complex precipitate when the sample is injected into an ammoniacal copper solution. The precipitate is retained on a plastic or paper filtering device. A nitric acid stream dissolves the precipitate and carried the Cu(II) to the AAS detector. The chlorhexidine is determined over the range 5-20 ppm. The influence of interfering substances is investigated.
Martinez Calatayud
J
J
Departamento de Quimica Analitica, Facultad de C. Quimicas, Universidad de Valencia, Spain.
Garcia Mateo
J V
JV
D001645:Biguanides; D002710:Chlorhexidine / Q000032:analysis*; D003300:Copper; D007202:Indicators and Reagents; D009566:Nitrates; D017942:Nitric Acid; D000644:Quaternary Ammonium Compounds; D013054:Spectrophotometry, Atomic
D001645:Biguanides; D007202:Indicators and Reagents; D009566:Nitrates; D000644:Quaternary Ammonium Compounds; D017942:Nitric Acid; D003300:Copper; D002710:Chlorhexidine