Radioimmunoimaging for diagnosis of bone marrow involvement in breast cancer and malignant lymphoma.
Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled murine monoclonal IgG1 antibody directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen. Immunoscintigraphy revealed more lesions than did bone scanning in both patient groups. This method offers a sensitive, cost-effective, and easy-to-perform whole body technique for evaluating metastatic spread.
Reske
S N
SN
Department of Nuclear Medicine, Rheinisch-Westfälische Technische Hochschule, Federal Republic of Germany.
Karstens
J H
JH
Gloeckner
W
W
Steinsträsser
A
A
Schwarz
A
A
Ammon
J
J
Buell
U
U
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015815:Cell Adhesion Molecules; D003429:Cross Reactions; D005069:Evaluation Studies as Topic; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013667:Technetium
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D013667:Technetium