Plasma beta-endorphin, ACTH and cortisol secretion in man after nasal spray administration of calcitonin.
Beta-endorphin, ACTH and cortisol secretion were measured in twelve healthy adult males after nasal spray administration 200 IU salmon calcitonin. A significant increase in plasma beta-endorphin, from 19.2 ng/l under basal conditions to a peak of 27.1 ng/l at 30 min was recorded. Plasma ACTH and cortisol were not affected. In individual subjects the beta-endorphin level was increased in eight of the twelve, ACTH rose in three and cortisol did not change in any of them. The data indicate that calcitonin induced a beta-endorphin increase independent of enhanced corticotrophin-cortisol release.
Franceschini
R
R
Department of Internal Medicine, University of Genoa, Italy.
Cataldi
A
A
Barreca
T
T
Salvemini
M
M
Rolandi
E
E
D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002116:Calcitonin / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D006854:Hydrocortisone