title: Electrophysiological and pharmacological properties of putative A13 incertohypothalamic dopamine neurons in the rat.
abstract: A13 incertohypothalamic dopamine (DA) neurons were labelled with antibodies raised to tyrosine hydroxylase in the male rat. Electrophysiologically, these neurons could be distinguished from their neighboring non-DA cells by their wide action potentials (greater than 2 ms), slow firing rates (0-3.8 impulses/s) and by the ability of iontophoresed DA and systemically administered apomorphine to inhibit impulse flow. Low doses of the antipsychotic drug haloperidol attenuated DA's response and reversed the apomorphine-inhibition of impulse flow.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
authors.forename: M K
authors.initials: MK
authors.lastname: Sanghera
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D014446:Tyrosine 3-Monooxygenase; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine