Employment of magnet-susceptible microparticles for the targeting of drugs.
It has been demonstrated in cats that magnet-susceptible microspheres and liposomes containing neuromuscular blocking agents (dipyronium, pyrocurinum and diadonium) caused a deeper inhibition of the neuromuscular transmission in the limb placed in the magnetic field than in the control limb located beyond the field. The microparticles containing a short-acting neuromuscular blocking agent diadonium appeared to have the highest selectivity of action. The present method allows a pronounced neuromuscular block in a target area to be achieved without noticeable effect on PCO2 of the exhaled air.
Kharkevich
D A
DA
Department of Pharmacology, First Medical Institute, Moscow, USSR.
Alyautdin
R N
RN
Filippov
V I
VI
D000818:Animals; D002415:Cats; D004337:Drug Carriers; D004573:Electrolytes; D008081:Liposomes; D008280:Magnetics; D008863:Microspheres; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage
D004337:Drug Carriers; D004573:Electrolytes; D008081:Liposomes; D009466:Neuromuscular Blocking Agents