Effect of selenite on the toxicity of cis-DDP in mice: estimation of trace elements.
A significant accumulation of copper, zinc, iron, rubidium and bromine, in addition to platinum, was observed in kidneys and liver of mice treated with cis-DDP. This observation suggests that the toxicity of cis-DDP is due to the overall accumulation of trace elements and not only to the expected high platinum levels. Sodium selenite administration prior to cis-DDP results in fast clearance of all these trace elements from kidneys and liver; control levels are reached within 6 days. This may explain the important reduction in cis-DDP toxicity following selenite administration. An X-ray fluorescence (XRF) facility was used for the evaluation of the trace elements.
Shenberg
C
C
Soreq Nuclear Research Center, Yavne, Israel.
Izak-Biran
T
T
Mantel
M
M
Rachmiel
B
B
Weininger
J
J
Chaitchik
S
S
D000818:Animals; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D008657:Metabolic Clearance Rate / Q000502:physiology; D051379:Mice; D008813:Mice, Inbred ICR; D012643:Selenium / Q000494:pharmacology*; D018038:Sodium Selenite; D014131:Trace Elements / Q000032:analysis* / Q000493:pharmacokinetics
D014131:Trace Elements; D012643:Selenium; D018038:Sodium Selenite; D002945:Cisplatin