Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin. A prospective study.
In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified.
Bosch
F H
FH
Department of Medicine, University Hospital Nijmegen, The Netherlands.
Hoitsma
A J
AJ
Janssen
H P
HP
van Loon
A M
AM
Koene
R A
RA
D003524:Cyclosporins / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology*; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects; D011446:Prospective Studies
D003524:Cyclosporins; D011241:Prednisone