Renal effects of vanadate in rats.
In conscious rats, administration of vanadate is followed by a distinct and statistically significant diuretic effect. The increase in renal excretion of sodium dominates in comparison with other electrolytes. After i.p. administration vanadate is effective for 30 to 60 min. In anesthetized rats an excessive saline load and i.v. administration of vanadate do not prolong the renal effectiveness of vanadate. A long lasting diuretic effect is measurable during a constant infusion of vanadate. p-Aminohippurate transport in renal cortical slices can be inhibited by adding vanadate to the incubation medium. Vanadate administered in vivo in diuretically effective doses influences the p-aminohippurate transport in consectively prepared renal cortical slices. A 50% inhibition of Na+/K+-ATPase can be provoked by i.p. administration of 0.6 mg vanadate/100 g b.m. whereas the maximal increase in renal excretion of sodium is measurable following 0.5 mg vanadate/100 g b.m.
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, DDR.
Pfeifer
R
R
Grau
P
P
Reznik
L
L
D000818:Animals; D001806:Blood Urea Nitrogen; D004231:Diuresis / Q000187:drug effects; D004573:Electrolytes / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014563:Urodynamics / Q000187:drug effects; D014638:Vanadates / Q000633:toxicity*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D004573:Electrolytes; D014638:Vanadates; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D010130:p-Aminohippuric Acid