[A preliminary study on the relation of peripheral blood lymphocyte beta-adrenoceptors and airway reactivity in asthmatics].
The beta-adrenoceptors on intact peripheral blood lymphocytes were studied in 21 allergic asthmatics. 11 TDI asthmatics and 17 normal subjects with radioligand binding assay technique. The airway responsiveness to methacholine provocation test was determined. The results indicated that beta-adrenoceptor Bmax values in allergic and TDI asthmatics were reduced but the affinity between receptor and ligand was increased there was a positive correlation between the values of Bmax and FEV1%, V25/Pr in both asthmatic groups, a positive correlation between the values of Bmax and PC20 in allergic asthmatics. The beta-adrenoceptor responsiveness was remarkably reduced in allergic asthmatics.
Yang
Z F
ZF
D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011943:Receptors, Adrenergic, beta