The quinoxalinediones antagonise the visual firing of sustained retinal ganglion cells.
The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) has no effect. Thus, the endogenous excitatory amino acid released onto these cells on visual stimulation acts at non-NMDA receptors.
Kay
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Vision Research Unit of Sherrington School, Rayne Institute, St. Thomas' Hospital, London, U.K.
Ikeda
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D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D002415:Cats; D066298:In Vitro Techniques; D007478:Iontophoresis; D010879:Piperazines / Q000494:pharmacology*; D011810:Quinoxalines / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012160:Retina / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000502:physiology
D010879:Piperazines; D011810:Quinoxalines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C056723:FG 9041; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid