HTLV-1 and polymyositis in Jamaica.
IgG antibodies to human T-cell lymphotropic virus (HTLV-1) were found in 11 of 13 (85%) Jamaican patients with idiopathic adult polymyositis. The association was first observed in 7 patients with polymyositis who were included in a control group of 100 patients with neurological and neuromuscular diseases in a serological investigation of the prevalence of HTLV-1 antibody in patients with tropical spastic paraparesis. All 7 patients with polymyositis were positive for the antibody by an enzyme-linked immunosorbent assay, confirmed by western blot. Because of this striking association a further 6 patients with polymyositis were identified and tested, 4 of whom were also seropositive for HTLV-1 antibody.
Morgan
O S
OS
Department of Medicine, University of the West Indies, Kingston, Jamaica.
Rodgers-Johnson
P
P
Mora
C
C
Char
G
G
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis*; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007563:Jamaica; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009220:Myositis / Q000150:complications* / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000473:pathology; D012737:Sex Factors
D015481:HTLV-I Antibodies; D007074:Immunoglobulin G