title: [Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].
abstract: Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
authors.forename: A
authors.initials: A
authors.lastname: Modesti
authors.forename: G
authors.initials: G
authors.lastname: D'Orazi
authors.forename: S
authors.initials: S
authors.lastname: Scarpa
authors.forename: S
authors.initials: S
authors.lastname: Mezi
authors.forename: F
authors.initials: F
authors.lastname: Gatti
authors.forename: G
authors.initials: G
authors.lastname: Aloise
authors.forename: D
authors.initials: D
authors.lastname: Gerace
authors.forename: P
authors.initials: P
authors.lastname: Guglielmi
authors.forename: L
authors.initials: L
authors.lastname: Simonelli
authors.forename: M
authors.initials: M
authors.lastname: Modesti
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000648:ultrastructure*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry* / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis*; D005355:Fibrosis; D006801:Humans; D016253:Microscopy, Immunoelectron
chemical_list: D003094:Collagen
vernacular_title: Studio ultrastrutturale ed immunoelettromicroscopico dello stroma desmoplastico nel carcinoma della mammella.