Novel CNS-directed drug delivery systems in Alzheimer's disease and other neurological disorders.
Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating Alzheimer's disease (AD) and other neurological diseases by the appropriate manipulation of neurotransmitters, neuromodulators, neurohormones or neurotrophic factors. Clinical application of this knowledge may, however, be inhibited by long standing problems with drug delivery to the central nervous system (CNS). Novel, CNS-directed, drug delivery systems might be used to overcome many of these problems. The problems encountered in drug delivery to the brain, present experience with the clinical use of some novel drug delivery systems and the advantages and disadvantages of these systems will be discussed.
Harbaugh
R E
RE
Section of Neurosurgery, Dartmouth-Hitchock Medical Center, Hanover, NH 03756.
D000544:Alzheimer Disease / Q000188:drug therapy*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001927:Brain Diseases / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007260:Infusion Pumps; D009417:Nerve Tissue / Q000637:transplantation
D001626:Bethanechol Compounds; D018723:Bethanechol