Changes in chlorpromazine induced CNS effects when associated with other neuroleptics and anxiolytics.
A set of test (General behavior, traction, chimney, rotarod, conditioned reflexes, curiosity and potentiation of barbiturate sleep) were given in addition to studying the hypothermia of associations of chlorpromazine with various neuroleptic and one anxiolytic (Perphenazine, clothiapine, haloperidol and diazepam), which demonstrated an evident enhancement of the depressant effects of chlorpromazine when combined with clothiapine and haloperidol.
Pérez-Raya
M D
MD
Risco
S
S
Navarro
C
C
Jimenez
J
J
Cabo
J
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D002746:Chlorpromazine