title: [Isolation and in vitro and in vivo characteristics of a clone of a wild Aujeszky disease virus resistant to bromovinyldeoxyuridine].
abstract: The antiviral activity of bromovinyldeoxyuridine has been studied on the wild type of pseudorabies virus. A heterogenicity of viral populations has been observed. A resistant clone presented special characteristics both in vitro (large syncytia, round cells) and in vivo (reduced pathogenicity and immunogenic power).
authors.affiliation: Ecole Nationale Vétérinaire de Lyon, Services de maladies contagieuses, France.
authors.forename: G
authors.initials: G
authors.lastname: Bijlenga
authors.forename: L
authors.initials: L
authors.lastname: Joubert
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000494:pharmacology / Q000031:analogs & derivatives; D002415:Cats; D002417:Cattle; D004285:Dogs; D004352:Drug Resistance, Microbial; D005260:Female; D011558:Herpesvirus 1, Suid / Q000032:analysis / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D051379:Mice; D014776:Virus Cultivation
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine
vernacular_title: Isolement et caractères in vitro et in vivo d'un clone de virus sauvage de la maladie d'Aujeszky résistant à la bromovinyldésoxyuridine.