The beta-adrenergic agonist isoproterenol suppresses experimental allergic encephalomyelitis in Lewis rats.
Treatment with the beta-adrenergic agonist isoproterenol suppresses clinical and histological experimental allergic encephalomyelitis in Lewis rats. The effect of isoproterenol treatment is greater when the drug is given from the time of immunization through the acute phase of the illness or from 8 to 14 days post-immunization than when given for the first 7 days after immunization.
Chelmicka-Schorr
E
E
Department of Neurology, University of Chicago, IL 60637.
Kwasniewski
M N
MN
Thomas
B E
BE
Arnason
B G
BG
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000503:physiopathology*; D007114:Immunization; D007545:Isoproterenol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D012720:Severity of Illness Index; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D011433:Propranolol; D007545:Isoproterenol