[Oral administration of nicotine and plasma levels of ACTH and cortisol in smokers and non-smokers].
Plasma ACTH and cortisol levels after oral administration of nicotine (chewing gum containing nicotine 2 mg) in short and long time (10 and 45 min) were studied in smokers and non smokers. Non smokers after short time administration showed significant rise in ACTH and cortisol. No modifications were seen in the other groups of subjects. These data confirm that nicotine stimulates hypophysis-adrenal axis in non smokers and that this effect is connected with nicotine contents of cigarettes rather than other volatile substances.
Sellini
M
M
Sartori
M P
MP
Letizia
C
C
Dimitriadis
E
E
Bassi
R
R
Baccarini
S
S
D000284:Administration, Oral; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D012907:Smoking / Q000097:blood*
D009538:Nicotine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Somministrazione orale di nicotina e livelli plasmatici di ACTH e di cortisolo in fumatori e non fumatori.