Effect of enalapril on handling of a sodium chloride load by genetically hypertensive and normotensive rats.
1. Enalapril was given in the drinking water (300 mg/L) for 4.5 days to normotensive (N) and genetically hypertensive (GH) rats on zero sodium intake. An intraperitoneal NaCl load was given 12 h after enalapril was started. 2. Enalapril did not increase the maximum rate of sodium excretion, but caused the rats to excrete more than the load in the first 24 h and then to have a slow fall in body sodium while on a sodium-free diet. 3. In terms of the Strauss et al. (1958) concept of body sodium, enalapril appears to lower the basal level. However, in addition it causes a slow leak of sodium which becomes apparent when sodium intake is very low.
Ledingham
J M
JM
Wellcome Medical Research Institute, University of Otago Medical School, Dunedin, New Zealand.
Simpson
F O
FO
D000818:Animals; D004656:Enalapril / Q000494:pharmacology*; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000378:metabolism*; D012979:Sodium Radioisotopes
D012979:Sodium Radioisotopes; D012965:Sodium Chloride; D004656:Enalapril