title: Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.
abstract: In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octapeptide SMS 201-995 solely inhibits the forskolin-activated adenylate cyclase in the 3 preparations. These results suggest that the SRIF-specific stimulation of adenylate cyclase may be a functional correlate for the brain-specific SRIF receptor subpopulation, whereas the SRIF and SMS 201-995 inhibition of stimulated adenylate cyclase correlate with the SRIF receptor subpopulation present in brain and non-neuronal tissues.
authors.affiliation: Sandoz Preclinical Research, Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Markstein
authors.forename: K A
authors.initials: KA
authors.lastname: Stöckli
authors.forename: J C
authors.initials: JC
authors.lastname: Reubi
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005576:Colforsin / Q000494:pharmacology; D003342:Corpus Striatum / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006624:Hippocampus / Q000201:enzymology; D008297:Male; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013378:Substantia Nigra / Q000201:enzymology
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D005576:Colforsin; D013004:Somatostatin; D000262:Adenylyl Cyclases