[Antifungal activity of itraconazole and ketoconazole investigated in vitro, determined with minimal inhibitory concentrations and mycelial cell transformation in Candida albicans].
Results of studies "in vitro" of the susceptibility of 82 strains of Candida albicans for itraconazole and ketoconazole have been report. The strains were isolated from lesions of the mucous membranes and skin. The susceptibility of Candida albicans was tested to Minimal Inhibitory Concentration (MIC) and Total Inhibition Germination Tubes (TI100). The values of MICs and TI100 of itraconazole were 0.02-35.0 micrograms/ml and 0.02-18.0 micrograms/ml, respectively. The similar values of MICs and TI100 of ketoconazole were 0.04-80.0 micrograms/ml and 0.04-20.0 micrograms/ml. It has been showed that TI100 can be used as preliminary and rapid test of Candida albicans susceptibility for these drugs.
Urbanowski
S
S
Nierebińska
E
E
Gwieździński
Z
Z
D000935:Antifungal Agents; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects*; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole
Aktywność przeciwdrozdzakowa itrakonazolu i ketokonazolu w badaniach in vitro określana za pomoca minimalnych stezeń hamujacych i mycelialnej transformacji komórek Candida albicans.