title: Genetic diversity of simian immunodeficiency virus.
abstract: We have demonstrated that the genetic diversity of simian immunodeficiency virus from African green monkeys (SIVagm) is much greater than that observed previously for individual HIV-1, HIV-2, or SIVmac isolates. Extensive genetic variation among SIVagm isolates and the high prevalence of green monkey infection without disease suggest that the virus has been in the green monkey population for a long time. We have also demonstrated that SIV from a sooty mangabey monkey (isolate SMM-7) is closer to SIVmac and HIV-2 than to HIV-1 and SIVagm. The extensive genetic diversity of SIVagm and the relatedness of SIVsmm to HIV-2 warrant continued examination of SIVagm and SIVsmm isolates from dispersed geographic regions. SIV strains much more closely related to HIV-1, HIV-2, or SIVmac may be found which would be reasonable candidates for recent cross-species transmission.
authors.affiliation: New England Regional Primate Research Center, Southborough, MA.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Naidu
authors.forename: P
authors.initials: P
authors.lastname: Fultz
authors.forename: M D
authors.initials: MD
authors.lastname: Daniel
authors.forename: R C
authors.initials: RC
authors.lastname: Desrosiers
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002520:Cercopithecidae / Q000382:microbiology; D002522:Chlorocebus aethiops / Q000382:microbiology; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000032:analysis; D005002:Ethiopia; D014644:Genetic Variation; D007630:Kenya; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D004279:DNA, Viral