Injection of catalytic subunit of cyclic AMP-dependent protein kinase speeds up the development of junctional communication in the embryo.
Using the time course of high capacity junctional communication development in endoderm of the early Xenopus embryo as the measure the effect of cAMP and the catalytic subunit of cAMP-dependent protein kinase on this development has been investigated. It is found that while cAMP has no effect on this development the catalytic subunit strongly speeds it up. The discrepancy may reflect the high concentration of cAMP and low concentration of effective cAMP-dependent protein kinase in endoderm cells of the early Xenopus embryo.
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D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D004707:Endoderm / Q000166:cytology*; D007365:Intercellular Junctions / Q000187:drug effects*; D011494:Protein Kinases / Q000494:pharmacology*; D014981:Xenopus / Q000196:embryology*
D000242:Cyclic AMP; D011494:Protein Kinases