title: Enhancement of u.v.-induced skin carcinogenesis in the hairless mouse by inoculation with cell-free extracts of skin tumours.
abstract: The presence of papillomaviral-like DNA has been described in ultraviolet light-induced tumours in the skin of the hairless mouse (14). Here we describe the effects of the inoculation of cell-free extracts of ultraviolet light-induced tumours into the scarified skin of normal hairless mice, prior to exposure of the mice to a cumulative carcinogenic dose of ultraviolet light. Extracts from papillomas or squamous cell carcinomas enhanced the susceptibility of the inoculated mice to ultraviolet light-induced tumorigenesis, if the extracts contained papillomaviral DNA sequences detected by cross-hybridization with Mastomys natalensis papillomaviral DNA. The recipient mice developed a greater tumour incidence, tumour yield, tumour diameter and degree of malignancy.
authors.affiliation: Department of Veterinary Pathology, University of Sydney, NSW, Australia.
authors.forename: V E
authors.initials: VE
authors.lastname: Reeve
authors.forename: G E
authors.initials: GE
authors.lastname: Greenoak
authors.forename: P J
authors.initials: PJ
authors.lastname: Canfield
authors.forename: C
authors.initials: C
authors.lastname: Boehm-Wilcox
authors.forename: P A
authors.initials: PA
authors.lastname: Tilbrook
authors.forename: J K
authors.initials: JK
authors.lastname: Kulski
authors.forename: C H
authors.initials: CH
authors.lastname: Gallagher
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D002457:Cell Extracts / Q000008:administration & dosage*; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D004198:Disease Susceptibility; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009115:Muridae / Q000382:microbiology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000235:genetics / Q000276:immunology; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D010212:Papilloma / Q000209:etiology* / Q000235:genetics; D027383:Papillomaviridae / Q000235:genetics; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014020:Tissue Extracts / Q000008:administration & dosage*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D002457:Cell Extracts; D004273:DNA, Neoplasm; D004279:DNA, Viral; D014020:Tissue Extracts