Modulation of immune suppression and enhanced tumorigenesis in retrovirus tumor challenged chickens treated with vitamin E.
Vitamin E(dl-alpha-tocopherol) dissolved in ethanol with polyethylene glycol as the vehicle and administered by intraperitoneal injections of 0.1 mg/gm body weight at two day intervals, was demonstrated to be a potent immunomodulating reagent in young chickens challenged with avian reticuloendotheliosis virus-transformed tumor cells. Vitamin E treatment enhanced the mitogen-induced proliferative responses of spleen cells from age matched, unchallenged chickens; reduced the tumor cell-induced suppression of host splenic lymphocyte mitogen responses; and eliminated tumor cell-induced suppressor cell activity. However, inspite of an improved immune status the vitamin E treated-tumor cell challenged chickens exhibited enhanced tumorigenesis.
Kline
K
K
Division of Nutrition, University of Texas, Austin 78712.
Sanders
B G
BG
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D001356:Reticuloendotheliosis virus / Q000235:genetics*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D008934:Mitogens; D014810:Vitamin E