[Occurrences of human papilloma virus DNA in cervical carcinomas].
Out of 16 cases involving a cervical carcinoma that were investigated by Southern blot hybridization, found were human papilloma virus (HPV) types 16 and 18 DNA sequences in 8 (50%) and in one (6.3%), respectively. Six out of the 8 HPV 16-positive specimens were from squamous cell carcinomas, one was from an adenocarcinoma, and the remaining specimen was from an argyrophil small cell carcinoma. In 7 out of 9 HPV-positive specimens, the viral sequences were integrated in the tumor cell genome, whereas in the remaining two they were not integrated and remained circular and/or oligomeric in form.
Ichimura
H
H
Institute of Clinical Research, Kure National Hospital.
Yamasaki
M
M
Tamura
I
I
Kurimura
O
O
Kurimura
T
T
D000230:Adenocarcinoma / Q000032:analysis; D015139:Blotting, Southern; D018288:Carcinoma, Small Cell / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005814:Genes, Viral; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D002583:Uterine Cervical Neoplasms / Q000032:analysis*
D004279:DNA, Viral