Hydroxylamine dilates resistance blood vessels of the perfused rat kidney and mesentery.
Hydroxylamine (ED50 values, 47 +/- 8.9 nmol and 320 +/- 39 nmol) dilates resistance arterioles of the perfused noradrenaline-preconstricted rat kidney and mesentery. In this respect hydroxylamine was approximately 63x and 320x less potent than acetylcholine (ACh) and 15x and 128x less potent than nitroprusside in the two perfused organs studied. The vasodilator effect of hydroxylamine (unlike that of ACh) was unaffected by CHAPS de-endothelialization suggesting that its effect is independent of endothelium-derived relaxing factor (EDRF).
Moore
P K
PK
Biomedical Sciences Division, King's College, University of London, UK.
Burrows
L
L
Bhardwaj
R
R
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002793:Cholic Acids / Q000494:pharmacology; D006898:Hydroxylamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects*; D013152:Splanchnic Circulation / Q000187:drug effects*; D014665:Vasodilator Agents
D002793:Cholic Acids; D006898:Hydroxylamines; D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine; C028213:3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate