Molecular genetic analysis of lymphoid tumors arising after organ transplantation.
A variety of gene analyses were performed on lymphoid tumors from transplant patients who received cyclosporine A for immunosuppression. Epstein-Barr virus DNA was detected in the tumors, and the structure of circular episomal virus DNA was used as a measure of cell clonality. This analysis was correlated with clonality determined by study of immunoglobulin gene rearrangement. Some of the tumors had DNA rearrangements near the c-myc gene. Analysis suggested the pathogenesis of the tumors and indicated four categories of lymphoproliferation, three neoplastic and one reactive.
Locker
J
J
Department of Pathology, School of Medicine, Presbyterian-University Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Nalesnik
M
M
D001402:B-Lymphocytes / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D015321:Gene Rearrangement; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008206:Lymphatic Diseases / Q000235:genetics* / Q000473:pathology; D008967:Molecular Biology / Q000379:methods*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011183:Postoperative Complications; D014180:Transplantation
D004279:DNA, Viral