title: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.
abstract: The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.
authors.affiliation: Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.
authors.forename: N K
authors.initials: NK
authors.lastname: Spurr
authors.forename: A C
authors.initials: AC
authors.lastname: Gough
authors.forename: K
authors.initials: K
authors.lastname: Stevenson
authors.forename: C R
authors.initials: CR
authors.lastname: Wolf
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D006899:Mixed Function Oxygenases / Q000235:genetics*; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D015342:DNA Probes; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A