title: Evidence that mutation patterns vary among Drosophila transposable elements.
abstract: In Drosophila melanogaster, codon usage in the open reading frames (ORFs) of transposable elements (TEs) differs greatly from that in other ORFs. In addition, while the ORFs from a single element are similar, there is considerable variation among elements. In the TE ORFs there are no indications of selection for the codons prevalent in the other D. melanogaster genes, but rather codon usage can be succinctly summarized in terms of the base composition at silent sites. We suggest that the particular silent site base composition of each TE is determined by an individual pattern of mutation. In many of the TEs there is an ORF encoding a protein with homology to reverse transcriptase; the amino acid sequences of these are quite divergent, and so it is possible that each of these incorporates certain mismatched bases at different frequencies during replication.
authors.affiliation: Department of Genetics, Trinity College, Dublin, Ireland.
authors.forename: D C
authors.initials: DC
authors.lastname: Shields
authors.forename: P M
authors.initials: PM
authors.lastname: Sharp
mesh_terms: D000818:Animals; D001482:Base Composition; D003062:Codon; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D009154:Mutation
chemical_list: D003062:Codon; D004251:DNA Transposable Elements