title: [Synthesis of eumelanin pigment precursors. II. 6-hydroxy-5-methoxy- and 5-hydroxy-6- methoxyindole].
abstract: Following up of specific melanogenesis metabolite excretion in the course of malignant melanoma disease is useful for the disease prognosis assessment. The authors elaborated a modified synthesis technique of 6-hydroxy-5-methoxy and 5-hydroxy-6-methoxyindole, eumelanin pigment precursors. The elaborated synthesis is economically and temporally reasonable and the synthesized compounds accord, as proved by means of elementary analysis, thin layer (TLC) and high performance liquid chromatography (HPLC) and last but not least by nuclear magnetic resonance (NMR), with demands for reference compounds needed for isomer hydroxymethoxyindole quantification in urine.
authors.affiliation: II. Ustav lékarské chemie a biochemie fakulty vseobecného lékarství, Univerzity Karlovy, Praha.
authors.forename: E
authors.initials: E
authors.lastname: Bubnová
authors.forename: A
authors.initials: A
authors.lastname: Budĕsínská
authors.forename: Z
authors.initials: Z
authors.lastname: Schwippelová
authors.forename: B
authors.initials: B
authors.lastname: Matous
authors.forename: T
authors.initials: T
authors.lastname: Trnka
mesh_terms: D007211:Indoles / Q000138:chemical synthesis; D008543:Melanins / Q000138:chemical synthesis*
chemical_list: D007211:Indoles; D008543:Melanins; C041877:eumelanin; C062394:6-hydroxy-5-methoxyindole; C038282:5-hydroxy-6-methoxyindole
vernacular_title: Syntéza prekurzorů pigmentu eumelaninu. II. 6-hydroxy-5-methoxy- a 5-hydroxy-6-methoxyindol.