Removal of anti-HLA antibodies by extracorporeal immunoadsorption to enable renal transplantation.
10 highly and persistently sensitised patients awaiting renal transplantation underwent extracorporeal immunoadsorption to remove anti-HLA antibodies. 7 patients have since received transplants. Only 1 allograft has been lost because of rejection, and there have been no serious side-effects attributable to treatment. Extracorporeal immunoadsorption may therefore be of considerable value in the management of highly sensitised patients.
Palmer
A
A
Renal Unit, Dulwich Hospital, London.
Taube
D
D
Welsh
K
K
Bewick
M
M
Gjorstrup
P
P
Thick
M
M
D000328:Adult; D000918:Antibody Specificity; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011241:Prednisone / Q000008:administration & dosage
D006680:HLA Antigens; D007518:Isoantibodies; D003520:Cyclophosphamide; D011241:Prednisone