Plasma concentrations of 15-keto-13,14-dihydro-PGF-2 alpha, oestrone sulphate, oestradiol-17 beta and progesterone in pregnant guinea-pigs treated with polychlorinated biphenyls.
Guinea-pigs treated by gavage with a total dose of 100 mg polychlorinated biphenyls (PCB: Clophen A50) during Days 17-61 of gestation had higher plasma concentrations of 15-keto-13,14-dihydroprostaglandin F-2 alpha, oestrone sulphate and oestradiol-17 beta during the later stages of gestation than did vehicle-treated guinea-pigs. No changes were observed in plasma progesterone concentrations. Our results provide no support for the hypothesis that an enzyme-induced decrease in progesterone concentrations is the main cause of the fetal death observed in PCB-treated guinea-pigs.
Lundkvist
U
U
Department of Zoophysiology, Uppsala University, Sweden.
Kindahl
H
H
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D004785:Environmental Pollutants / Q000633:toxicity*; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood*; D004966:Estrogens, Conjugated (USP) / Q000097:blood; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006168:Guinea Pigs; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*
D004785:Environmental Pollutants; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D015237:Dinoprost; D011078:Polychlorinated Biphenyls; C017296:estrone sulfate