Diagnostic value of an immunoassay to detect anti Campylobacter pylori antibodies in non-ulcer dyspepsia.
An enzyme-linked immunosorbent assay (ELISA) for detection of IgG antibodies against Campylobacter pylori was used to examine sera from 70 patients with non-ulcer dyspepsia. 48 patients had C pylori associated gastritis according to culture or histology; mean optical density (OD) of the ELISA was significantly higher than that for the 22 patients with normal antral mucosa and absence of C pylori. Positive and negative predictive values for campylobacter-associated gastritis were 100% above OD 2.10 and below OD 1.00, respectively. Serology might replace endoscopy in the diagnosis of campylobacter-associated gastritis.
Loffeld
R J
RJ
Department of Internal Medicine, University Hospital Maastricht, Netherlands.
Stobberingh
E
E
Flendrig
J A
JA
van Spreeuwel
J P
JP
Arends
J W
JW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis*; D002167:Campylobacter / Q000276:immunology* / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000150:complications / Q000276:immunology; D004415:Dyspepsia / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D005756:Gastritis / Q000209:etiology / Q000276:immunology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011706:Pyloric Antrum / Q000382:microbiology; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000276:immunology*
D000907:Antibodies, Bacterial