In vivo studies on the effect of some insecticides on the hepatic activities of L-tryptophan 2,3-dioxygenase and pyridoxal phosphokinase of male mice.
The effect of Dimethoate, Carbaryl and Permethrin on the activities of liver L-tryptophan 2,3-dioxygenase (total-, holo-, and apo-forms) and pyridoxal phosphokinase of male mice was investigated. Dimethoate inhibited both enzyme systems after single and repeated dose treatment; except the dioxygenase holo-enzyme after repeated doses. Single dose of Carbaryl treatment inhibited the pyridoxal phosphokinase, total and holo-enzyme of L-tryptophan dioxygenase. However, the repeated dose treatment do not affect both enzyme systems. Permethrin inhibited only total-, holo- and apo-enzymes of L-tryptophan dioxygenase whereas repeated administration has no significant effect on both enzymes. The data indicate that these insecticides may induce abnormal tryptophan metabolism through which some endogenous bladder carcinogens are formed.
el-Toukhy
M A
MA
Department of Applied Medical Chemistry, Alexandria University, Egypt.
Ebied
S A
SA
Hassan
A A
AA
el-Sewedy
S M
SM
D000818:Animals; D012721:Carbaryl / Q000633:toxicity; D004117:Dimethoate / Q000633:toxicity; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D026023:Permethrin; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D011722:Pyrethrins / Q000633:toxicity; D011731:Pyridoxal Kinase / Q000037:antagonists & inhibitors*; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin; D014366:Tryptophan Oxygenase; D010770:Phosphotransferases; D011731:Pyridoxal Kinase; D012721:Carbaryl; D004117:Dimethoate