Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist.
The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (+/-)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.
Maj
J
J
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Rogóz
Z
Z
Skuza
G
G
Sowińska
H
H
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology; D015259:Dopamine Agents / Q000378:metabolism*; D004873:Ergolines / Q000378:metabolism*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D015259:Dopamine Agents; D004873:Ergolines; D015283:Citalopram; D000639:Amitriptyline; D019257:Quinpirole; D008803:Mianserin