Shedding of herpes simplex virus type 1 into saliva after surgery for oral and genital or urological cancer patients.
The shedding of herpes simplex virus type-1 (HSV-1) into the saliva was compared in 28 patients with oral cancer and 26 patients with genital or urological cancer. All subjects tested positive for HSV-1 specific antibody. A statistically significant (p less than 0.001) difference was found: infectious viruses were isolated from 12 (39.8%) of the oral cancer patients versus only 2 (7.6%) of the genital or urological patients. This indicates that direct stimulation of peripheral nerves during surgery was responsible for the greater reactivation of HSV-1.
Kameyama
T
T
Haikata
K
K
Nakamura
Y
Y
Murase
H
H
Yamamoto
S
S
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000382:microbiology / Q000601:surgery; D009369:Neoplasms / Q000382:microbiology / Q000601:surgery*; D012463:Saliva / Q000382:microbiology*; D018139:Simplexvirus / Q000145:classification / Q000302:isolation & purification*; D014565:Urogenital Neoplasms / Q000382:microbiology / Q000601:surgery