A clinical study into the possible intrinsic bradycardic activity of vecuronium.
Forty female patients received a standardised anaesthetic technique with thiopentone sodium and enflurane. Half of the patients received, under double-blind conditions, either physiological saline or glycopyrronium before induction of anaesthesia; 10 minutes after induction of anaesthesia, all patients received vecuronium 0.1 mg/kg. A further 10 patients received neither glycopyrronium nor vecuronium. The results show that vecuronium per se does not produce a decrease in heart rate.
Cozanitis
D A
DA
Surgical Hospital, Helsinki, Finland.
Erkola
O
O
D000328:Adult; D000768:Anesthesia, General; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004311:Double-Blind Method; D004737:Enflurane; D005260:Female; D006024:Glycopyrrolate; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D004737:Enflurane; D006024:Glycopyrrolate