[Effect of induction of antibodies to serotonin on alcohol consumption and the status of the brain mediator system in rats with various degrees of alcohol motivation].
Active immunization with serotonin-protein conjugate in rat experiments increased ethanol preference in animals with weak alcoholic motivation but reduced it in those with a high alcohol consumption. The level of antibodies to serotonin in blood was higher in alcohol-preferring rats than in water-preferring animals. The reduction of alcohol intake correlated with reduction of the level of 5-OH-indoleacetic acid in the animals' hypothalamus. It is assumed that the contrary effect of immunization with serotonin-protein conjugate on the alcoholic behavior of animals with a different initial level of alcoholic motivation is linked with the difference in their neurochemical organization.
Bobkova
N B
NB
Plakkhinas
L A
LA
Basharova
L A
LA
Vetrilé
L A
LA
Evseev
V A
VA
D000428:Alcohol Drinking; D000818:Animals; D000917:Antibody Formation; D001921:Brain / Q000502:physiology*; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000276:immunology*
D018377:Neurotransmitter Agents; D012701:Serotonin
Vliianie induktsii antitel k serotoninu na potreblenie alkogolia i sostoianie mediatornykh sistem mozga u krys s raznoĭ vyrazhennost'iu alkogol'noĭ motivatsii.