title: [Clinico-pathologic case of slowly progressive herpes simplex encephalitis without temporal necrosis].
abstract: A case of herpes simplex encephalitis (HSE) is reported. The patient experienced short term memory disorders and irritability progressing over 3 months, without seizures or fever. The CSF was normal. CT showed a small low density area in the right posterior orbito-frontal region. At post-mortem examination, one month later, the temporal cortex appeared largely spared by necrosis, which involved the posterior orbito-frontal areas. Cowdry type A inclusions, herpes virus like particles and fluorescent reaction with HSV1 monoclonal antibodies strongly supported the diagnostic. Such atypical cases of long duration have apparently seldom been reported. They suggest that HSE should be considered in the differential diagnosis of a subacute encephalopathy.
authors.affiliation: Service de Neurologie A, INSERM U.298, CHU Angers.
authors.forename: F
authors.initials: F
authors.lastname: Dubas
authors.forename: I
authors.initials: I
authors.lastname: Pénisson-Besnier
authors.forename: A
authors.initials: A
authors.lastname: Pouplard-Barthelaix
authors.forename: D
authors.initials: D
authors.lastname: Le Gall
authors.forename: J
authors.initials: J
authors.lastname: Emile
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000473:pathology*; D006561:Herpes Simplex / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008297:Male; D011379:Prognosis; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
vernacular_title: Un cas clinico-pathologique d'encéphalite herpétique lentement progressive sans nécrose temporale.