Sputum levels of fluconazole in humans.
We measured fluconazole levels in sputum samples obtained from 11 bronchiectatic volunteers at 4 and 24 h after a single oral dose of 150 mg of fluconazole. Levels in sputum were similar to levels in plasma at both times.
Ebden
P
P
Department of Medicine, Glenfield General Hospital, Leicester, United Kingdom.
Neill
P
P
Farrow
P R
PR
D000368:Aged; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001987:Bronchiectasis / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D015725:Fluconazole; D006801:Humans; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000378:metabolism*; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000935:Antifungal Agents; D014230:Triazoles; D015725:Fluconazole