[Recovery kinetics of hematopoiesis after peripheral blood stem cell autotransplantation].
Hematopoietic recovery kinetics was evaluated in five children with therapy-refractory cancers who received peripheral blood stem cell autotransplantation (PBSCT) following marrow-ablative chemotherapy. Four children received graft containing more than 1.5 X 10(4) CFU-GM/kg and days required to achieve granulocyte counts of greater than 0.5 X 10(9)/l were 6, 10, 13, and 18, respectively. One patient received 0.9 X 10(4) CFU-GM/kg, but, recovery of granulopoiesis was retarded (greater than 30 days). The days required to achieve platelet count of greater than 50 X 10(9)/l were 12, 15, 16, 195, and greater than 240, respectively. Transient decrease of blood cell counts developed 3 to 5 weeks after transplantation and thereafter, the recovery of hematopoiesis became stable. With the use of a large number of progenitors, PBSCT seems to be safe and effective new type of stem cell rescue operation as an alternative to bone marrow transplantation.
Takaue
Y
Y
Dept. of Pediatrics, University of Tokushima.
Watanabe
T
T
Kawano
Y
Y
Abe
T
T
Suzue
T
T
Satoh
J
J
Kamata
K
K
Huq
M A
MA
Ninomiya
T
T
Kuroda
Y
Y
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006098:Granulocytes; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D010976:Platelet Count; D013601:T-Lymphocytes; D014182:Transplantation, Autologous