title: Synthesis and quantitative structure-activity relationships of analeptic agents related to dimefline.
abstract: Some new dimefline-type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds.
authors.forename: M
authors.initials: M
authors.lastname: Recanatini
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: P
authors.initials: P
authors.lastname: Giusti
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000697:Central Nervous System Stimulants; D005419:Flavonoids; C015154:dimefline