title: Shedding of herpes simplex virus type 1 into saliva after surgery for oral and genital or urological cancer patients.
abstract: The shedding of herpes simplex virus type-1 (HSV-1) into the saliva was compared in 28 patients with oral cancer and 26 patients with genital or urological cancer. All subjects tested positive for HSV-1 specific antibody. A statistically significant (p less than 0.001) difference was found: infectious viruses were isolated from 12 (39.8%) of the oral cancer patients versus only 2 (7.6%) of the genital or urological patients. This indicates that direct stimulation of peripheral nerves during surgery was responsible for the greater reactivation of HSV-1.
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: K
authors.initials: K
authors.lastname: Haikata
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Murase
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000382:microbiology / Q000601:surgery; D009369:Neoplasms / Q000382:microbiology / Q000601:surgery*; D012463:Saliva / Q000382:microbiology*; D018139:Simplexvirus / Q000145:classification / Q000302:isolation & purification*; D014565:Urogenital Neoplasms / Q000382:microbiology / Q000601:surgery