Transformation of myelodysplasia to acute myeloid leukaemia during psoralen photochemotherapy (PUVA) treatment of psoriasis.
A patient with stable chronic myelomonocytic leukaemia was treated with 8-methoxypsoralen photochemotherapy (PUVA) for erythrodermic psoriasis. After 4 months, transformation to acute myeloid leukaemia (AML) occurred. We would suggest caution when considering PUVA therapy in patients with pre-leukaemic disorders.
Sheehan-Dare
R A
RA
Department of Dermatology, General Infirmary, Leeds, England.
Cotterill
J A
JA
Barnard
D L
DL
D000368:Aged; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000209:etiology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications*; D008297:Male; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*