Role of excitatory amino acids in brain injury caused by hypoxia-ischemia, status epilepticus, and hypoglycemia.
Glutamate, the major excitatory neurotransmitter of the brain, mediates neuronal injury from hypoxia-ischemia, hypoglycemia, and status epilepticus. Drugs that block glutamate receptors, particularly the N-methyl-D-aspartate (NMDA) receptor, protect neurons from these insults. Noncompetitive antagonists of NMDA receptors have the potential to prevent perinatal neurologic morbidity.
Clark
G D
GD
Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, Missouri.
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002470:Cell Survival; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology; D005971:Glutamates / Q000502:physiology*; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D009474:Neurons / Q000502:physiology; D011247:Pregnancy; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology; D013226:Status Epilepticus / Q000503:physiopathology*
D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter