Species relationships for plasma angiotensin converting enzyme activity using a furanacryloyl tripeptide substrate.
Angiotensin converting enzyme (ACE; EC 3.4.15.1) activities were compared in plasma samples obtained from three species using a furanacryloyl tripeptide substrate. The enzyme activity observed in Wistar rat plasma was higher than the activities observed in the other two species. Using this substrate, human and canine plasma enzyme activities were similar-unlike published data where hippuryl-histidyl-leucine was used as substrate.
Evans
G O
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Department of Drug Safety Evaluation, Wellcome Research Laboratories, Kent, England.
D000818:Animals; D004285:Dogs; D006801:Humans; D009842:Oligopeptides; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013379:Substrate Specificity
D009842:Oligopeptides; C038275:2-furanacryloyl-phenylalanyl-glycyl-glycine; D007703:Peptidyl-Dipeptidase A