title: An ultrastructural evaluation of cell heterogeneity in invasive ductal carcinomas of the human breast. II. An in vitro study.
abstract: The ultrastructural characterization of the present continuous cell line, derived from a primary ductal infiltrating carcinoma (d.i.c.) of the human breast, has brought to light a remarkable morphological similarity with the original neoplastic cell population. A major parallelism is the permanent presence in culture of two categories of cells, exhibiting a strong isomorphism with the in vivo counterparts. The presence of well defined ultrastructural features, as duct-like structures, microvillous projections, junctional complexes and intracytoplasmic crypts, is a further confirmation of the breast cancer origin of this line. The significance and perspective of these findings are discussed.
authors.affiliation: Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo, Italia.
authors.forename: I
authors.initials: I
authors.lastname: Pucci-Minafra
authors.forename: S
authors.initials: S
authors.lastname: Minafra
authors.forename: R
authors.initials: R
authors.lastname: Alessandro
authors.forename: A M
authors.initials: AM
authors.lastname: Faccini
mesh_terms: D001943:Breast Neoplasms / Q000648:ultrastructure*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010641:Phenotype; D014407:Tumor Cells, Cultured / Q000648:ultrastructure