title: On the resting potential of isolated frog sympathetic neurons.
abstract: One of the oldest questions of electrophysiology, the origin of the resting potential, has yet to be answered satisfactorily for most cells. Isolated frog sympathetic neurons, studied with whole-cell recording, generally have resting potentials of approximately -75 mV with an input resistance of approximately 300 M omega. These properties are not expected from the M-type K+ current (IM) or from other ionic currents previously described in these cells. In the -60 to -110 M mV voltage region, at least three currents are present: an inwardly rectifying current (IQ), a resting current with little voltage sensitivity carried at least in part by K+, and a (Na+,K+)ATPase pump current. The resting K+ current, not IM or IQ is the primary ionic current near the resting potential under these conditions. The electrogenic pump contributes an additional approximately 10 mV of hyperpolarization.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: S W
authors.initials: SW
authors.lastname: Jones
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D002469:Cell Separation; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D008839:Microelectrodes; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D011188:Potassium / Q000378:metabolism / Q000502:physiology; D011892:Rana catesbeiana; D011894:Rana pipiens; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium