title: [3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients.
abstract: [3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.
authors.affiliation: Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
authors.forename: F
authors.initials: F
authors.lastname: Mack-Burkhardt
authors.forename: P
authors.initials: P
authors.lastname: Riederer
authors.forename: G F
authors.initials: GF
authors.lastname: Hebenstreit
authors.forename: G P
authors.initials: GP
authors.lastname: Reynolds
authors.forename: H B
authors.initials: HB
authors.lastname: Andrews
authors.forename: H
authors.initials: H
authors.lastname: Beckmann
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000378:metabolism*; D001923:Brain Chemistry; D003986:Dibenzocycloheptenes / Q000378:metabolism*; D016291:Dizocilpine Maleate; D005260:Female; D006801:Humans; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate