title: Induction of protooncogene fos by extracellular signals in primary glial cell cultures.
abstract: In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.
authors.affiliation: Institute of Biochemistry, Faculty of Medicine, University of Catania, Italy.
authors.forename: D F
authors.initials: DF
authors.lastname: Condorelli
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
authors.forename: A
authors.initials: A
authors.lastname: Arcidiacono
authors.forename: P
authors.initials: P
authors.lastname: Dell'Albani
authors.forename: F
authors.initials: F
authors.lastname: Ingrao
authors.forename: G
authors.initials: G
authors.lastname: Magrì
authors.forename: L
authors.initials: L
authors.lastname: Malaguarnera
authors.forename: R
authors.initials: R
authors.lastname: Avola
authors.forename: A
authors.initials: A
authors.lastname: Messina
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D015290:Second Messenger Systems / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D007051:Ibotenic Acid; D004815:Epidermal Growth Factor; D000242:Cyclic AMP; D013755:Tetradecanoylphorbol Acetate