title: [Comparison of blood flow and benzodiazepine receptor distribution in focal epilepsy: preliminary results of a SPECT study].
abstract: 99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT.2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz-receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123I-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Wilhelms-Universität Münster, BRD.
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
authors.forename: A
authors.initials: A
authors.lastname: Ludolph
authors.forename: O
authors.initials: O
authors.lastname: Schober
authors.forename: G
authors.initials: G
authors.lastname: Lottes
authors.forename: I
authors.initials: I
authors.lastname: Böttger
authors.forename: H F
authors.initials: HF
authors.lastname: Beer
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D001931:Brain Mapping; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D011963:Receptors, GABA-A / Q000032:analysis*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D011963:Receptors, GABA-A
vernacular_title: Vergleich von Blutfluss und Benzodiazepin-Rezeptor-verteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie.