title: Biochemical changes in airways after antigen inhalation.
abstract: These results suggest that activation of phospholipase A2 after antigen exposure triggers an increase in leukotriene synthesis resulting in inflammatory cell influx into the airway and contraction of bronchial smooth muscle. That is, it was demonstrated that inhaled antigen concerns with IgE-mast cell system, but, on the other hand it might act as non specific stimuli.
authors.affiliation: Second Department of Internal Medicine, Nagoya University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Satake
authors.forename: F
authors.initials: F
authors.lastname: Taki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000201:enzymology; D001980:Bronchi / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism; D006168:Guinea Pigs; D007975:Leukotriene B4 / Q000096:biosynthesis*; D009504:Neutrophils / Q000378:metabolism; D010047:Ovalbumin; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism
chemical_list: D010743:Phospholipids; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D007975:Leukotriene B4; D010047:Ovalbumin; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2