Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling.
We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril, foroxymithine, histargin and pepstatin. In spite of the apparently bizarre movements of the raw data, the analysis with autoregressive modelling unveiled the different modes of feedback regulations of the renin-angiotensin system under the influence of the various inhibitors. In order to interpret the in vivo actions of enzyme inhibitors, it seems essential to take feedback regulations into consideration.
Wada
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Aoyagi
T
T
D000626:Aminopeptidases / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D005246:Feedback; D043384:Glutamyl Aminopeptidase; D008433:Mathematics; D008962:Models, Theoretical; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011817:Rabbits; D012016:Reference Values; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000803:Angiotensin I; D000626:Aminopeptidases; D043384:Glutamyl Aminopeptidase; D007703:Peptidyl-Dipeptidase A; D012083:Renin