Hypophosphataemic rickets: final height and clinical symptoms in adults.
The heights and symptoms of 52 patients, aged at least 18 years, with X-linked hypophosphataemic rickets were analysed retrospectively; 47 had been seen as children and 5 were adult at their first examination. 2 patients were lost to follow-up. 3 patients had died but their adult heights were known. There was no evidence that any form of treatment (ie, vitamin D in high doses, vitamin D plus phosphate supplements, or calcitriol plus phosphate) had any effect on adult height, symptoms, or alkaline phosphatase levels. There was a negative relation between adult height and the number of osteotomies undergone. The complications of treatment, such as renal failure, which occurred secondary to vitamin D intoxication in 3 patients in their twenties, may outweight any possible benefits. Until a treatment is established as effective in controlled trials, it may be better that these patients remain untreated.
Stickler
G B
GB
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota.
Morgenstern
B Z
BZ
D000293:Adolescent; D000328:Adult; D001827:Body Height; D002117:Calcitriol / Q000627:therapeutic use; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D008040:Genetic Linkage; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D012189:Retrospective Studies; D012279:Rickets / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D014807:Vitamin D / Q000009:adverse effects / Q000627:therapeutic use; D014960:X Chromosome
D014807:Vitamin D; D002117:Calcitriol