Inhibition of lipopolysaccharide-induced alpha/beta-interferon synthesis by dopamine and the dopamine-1 agonist fenoldopam.
In vitro incubation of Listeria monocytogenes-immune spleen cells in the presence of dopamine or fenoldopam, a dopamine-1 (D1) agonist, inhibited alpha/beta-interferon (IFN) synthesis induced by the mitogen lipopolysaccharide (LPS), in a manner that appeared to be concentration dependent. In addition, the inhibitory effect of dopamine and fenoldopam on the synthesis of IFN was prevented by incubating immune spleen cells in the presence of haloperidol, a D1 antagonist.
Andrade-Mena
C E
CE
Departamento de Investigación Científica, Facultad de Medicina, Universidad de Guadalajara, Mexico.
D000818:Animals; D001552:Benzazepines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D018492:Dopamine Antagonists; D005260:Female; D018818:Fenoldopam; D006220:Haloperidol / Q000494:pharmacology; D007370:Interferon Type I / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000502:physiology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D001552:Benzazepines; D018492:Dopamine Antagonists; D007370:Interferon Type I; D008070:Lipopolysaccharides; D018818:Fenoldopam; D006220:Haloperidol; D013936:Thymidine; D004298:Dopamine