Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs.
The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to speculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.
Meltzer
H Y
HY
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland.
Koenig
J I
JI
Nash
J F
JF
Gudelsky
G A
GA
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects*; D002090:Butyrophenones / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D003984:Dibenzazepines / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008473:Median Eminence / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D014150:Antipsychotic Agents; D002090:Butyrophenones; D003984:Dibenzazepines; D011954:Receptors, Dopamine; D004295:Dihydroxyphenylalanine; D011388:Prolactin; D003024:Clozapine; C008522:metylperon; D003345:Corticosterone