Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow.
We report a significant decrease in intraocular pressure after intravitreal injection of atrial natriuretic peptide (AP). There is also an increase in cGMP in iris-ciliary body preparations after exposure to physiologic concentrations of AP in vitro. We present evidence that after intravitreal AP administration there is a decrease in aqueous humor flow associated with the decrease in intraocular pressure. The changes in aqueous humor flow were estimated by automated fluorophotometry and aqueous humor ascorbate concentrations.
Korenfeld
M S
MS
Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Becker
B
B
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002924:Ciliary Body / Q000187:drug effects; D006152:Cyclic GMP / Q000378:metabolism*; D015590:Fluorophotometry; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D012636:Secretory Rate / Q000187:drug effects; D014822:Vitreous Body
D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP; D001205:Ascorbic Acid