Effects of bestatin on intrauterine growth of rat fetuses.
Pregnant Wistar rats were injected with bestatin, a specific inhibitor of aminopeptidase M. Placental aminopeptidase M activity was inhibited by injection of bestatin, and fetal body weight was statistically lower than that in the saline-injected or control group. Our present data suggest that placental aminopeptidase M plays an important role in fetal growth.
Furuhashi
M
M
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Mizutani
S
S
Kurauchi
O
O
Kasugai
M
M
Tomoda
Y
Y
D000469:Alkaline Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology; D018826:CD13 Antigens; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000196:embryology; D008861:Microsomes / Q000201:enzymology; D010920:Placenta / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D018826:CD13 Antigens; D007930:Leucine; C012211:ubenimex