title: Effect of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides on bacteria of the genus Clostridium.
abstract: Antibacterial effect of 17 ammonium compounds of the type of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides was tested on anaerobically sporulating bacteria of the genus Clostridium. A sizable antibacterial activity was displayed by five N,N'-bis(alkyldimethyl)-1,6-hexanediammonium dibromides and by four N,N'-bis(decyldimethyl)-alpha, omega-alkanediammonium dibromides. These compounds exhibited activity higher than, or comparable with, that of the reference standards Ajatin and Septonex. The maximum antibacterial activity was found in compounds whose alkyl chain contained 9-12 carbon atoms. Compounds with a lower number of carbon atoms in the chain (less than 8) exhibited a low activity.
authors.affiliation: Department of Microbiology, Virology and Immunology, Faculty of Sciences, Komenský University, Bratislava, Czechoslovakia.
authors.forename: V
authors.initials: V
authors.lastname: Cigáneková
authors.forename: J
authors.initials: J
authors.lastname: Kallová
authors.forename: F
authors.initials: F
authors.lastname: Devínsky
authors.forename: I
authors.initials: I
authors.lastname: Lacko
mesh_terms: D001548:Benzalkonium Compounds / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects*; D003016:Clostridium perfringens / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001548:Benzalkonium Compounds; D004202:Disinfectants; D000644:Quaternary Ammonium Compounds; C025729:Septonex; C015163:dimethyldodecylbenzylammonium