Non-specific hyperreactivity to pharmacological stimuli in tracheal and lung parenchymal strips of actively sensitized guinea-pigs.
The responsiveness of tracheal and lung parenchymal strips isolated from actively sensitized guinea-pigs to CaCl2 (in K+-depolarized tissue), KCl, acetylcholine and histamine was compared with that of strips from unsensitized animals. The concentration-response curves to the mentioned agonists exhibited, in the sensitized group, a left upward displacement (greater maximal effect, lesser effective concentration 50% and a steeper slope) compared with those obtained in the unsensitized group. These results indicate the existence of a non-specific increase in responsiveness in the airway smooth muscle from sensitized animals.
Ortiz
J L
JL
Departamento de Farmacología y Farmacotecnia Universitat de València, Spain.
Cortijo
J
J
Sanz
C
C
Perpiñá
M
M
Iriarte
C F
CF
Sarría
B
B
Esplugues
J
J
Morcillo
E J
EJ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D012710:Serum Albumin, Bovine; D011189:Potassium Chloride; D006632:Histamine; D002122:Calcium Chloride; D000109:Acetylcholine