title: The endocrinopathy of POEMS syndrome.
abstract: We describe the clinical features and post mortem findings in a patient with POEMS syndrome (P--polyneuropathy, O--organomegaly, E--endocrinopathy, M--M protein, S--skin changes), with particular emphasis on the evolution of the endocrinopathy over a three year period. In addition to gynaecomastia this case exhibited primary hypothyroidism and primary and secondary adrenal and gonadal failure. The widespread nature of the endocrine changes suggests that a circulating substance interferes with the action of trophic hormones, possibly by inhibiting second messenger production.
authors.affiliation: Department of Medicine, Western General Hospital, Edinburgh.
authors.forename: P M
authors.initials: PM
authors.lastname: Stewart
authors.forename: M A
authors.initials: MA
authors.lastname: McIntyre
authors.forename: C R
authors.initials: CR
authors.lastname: Edwards
mesh_terms: D004700:Endocrine System Diseases / Q000150:complications*; D006177:Gynecomastia / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D013577:Syndrome