title: Aggressive insulinoma with bone metastases.
abstract: This is the first report of the development of bone metastases in a patient with an insulinoma. Following the development of bone metastases, further chemotherapy with etoposide (VP-16) and cis-platinum was not successful and the patient's condition was rapidly fatal. This case demonstrates the unusually aggressive course and poor response to currently available chemotherapeutic agents of a malignant insulinoma. The clinical and diagnostic features of insulinomas are reviewed.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
authors.forename: C S
authors.initials: CS
authors.lastname: Hesdorffer
authors.forename: M
authors.initials: M
authors.lastname: Stoopler
authors.forename: J
authors.initials: J
authors.lastname: Javitch
mesh_terms: D007516:Adenoma, Islet Cell / Q000556:secondary*; D001859:Bone Neoplasms / Q000556:secondary*; D006801:Humans; D007340:Insulinoma / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms