Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development.
A dogmatic view of antigen processing is presented in outline, followed by a survey of unresolved issues in the subject. The activity of Thy 1 as an alloantigen, and allospecific MHC Class-II-restricted cytolytic T cells offer examples of exceptional cases of antigen presentation. Implications for the design of vaccines are drawn.
Chain
B M
BM
Department of Biology, University College London, UK.
Mitchison
N A
NA
Mitchison
T J
TJ
Davies
D H
DH
Marcinkiewicz
J
J
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens; D000954:Antigens, Surface; D001693:Biological Transport, Active; D000949:Histocompatibility Antigens Class II; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D018800:Thy-1 Antigens; D014612:Vaccines / Q000302:isolation & purification
D000941:Antigens; D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D018800:Thy-1 Antigens; D014612:Vaccines