Urinary enzymes and calcium oxalate urolithiasis.
Male Sprague-Dawley rats were challenged with various hyperoxaluric agents including ammonium oxalate, hydroxy-L-proline, and ethylene glycol. All treatments resulted in increased urinary oxalate. Associated with hyperoxaluria was an increase in urinary levels of renal enzymes, gamma-glutamyl transpeptidase, N-acetyl-beta-glucosaminidase, and alkaline phosphatase. Most of the rats did not demonstrate any significant change in urinary levels of beta-galactosidase. There was a highly significant positive correlation between urinary oxalate and N-acetyl-beta-glucosaminidase.
Khan
S R
SR
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610.
Shevock
P N
PN
Hackett
R L
RL
D000118:Acetylglucosaminidase / Q000652:urine; D000469:Alkaline Phosphatase / Q000652:urine; D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D003460:Crystallization; D004798:Enzymes / Q000652:urine*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000494:pharmacology; D006909:Hydroxyproline / Q000494:pharmacology; D008297:Male; D010070:Oxalates / Q000494:pharmacology / Q000652:urine; D019815:Oxalic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000378:metabolism* / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine
D004798:Enzymes; D005026:Ethylene Glycols; D010070:Oxalates; D002129:Calcium Oxalate; D019815:Oxalic Acid; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase; D019855:Ethylene Glycol; D006909:Hydroxyproline