Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells.
Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.
Geurts van Kessel
A
A
Department of Cell Biology and Genetics, Erasmus Univesity, Rotterdam, The Netherlands.
van Drunen
E
E
de Jong
B
B
Oosterhuis
J W
JW
Langeveld
A
A
Mulder
M P
MP
D000782:Aneuploidy; D015139:Blotting, Southern; D002881:Chromosomes, Human, Pair 12; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013736:Testicular Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured
D005819:Genetic Markers