[Characteristics of lymphocyte autoantigens].
Specificity of autoantibodies against lymphocyte antigens was assayed in sera of patients with autoimmune hematologic diseases, leukemias, secondary immunodeficiencies as well as in sera of persons seropositive to antibodies against retroviruses HTLV-I and HTLV-III. Autoantigens of the lysates of stimulated peripheral blood lymphocytes and Hut-102 cells were characterized with the aid of immune blotting and radioimmunoprecipitation. No differences were found in autoantigen spectra identified by sera from patients belonging to different groups. Autoantigens 75 cd, 60 cd, 50 cd and 12 cd occurring in both cell types were demonstrable at a greater frequency. Some of the sera also demonstrated the total antigens 34 cd and 29 cd. The role of autoantigens in the pathology development is discussed.
Etkin
A F
AF
Gurevich
M M
MM
D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000032:analysis* / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D006800:Deltaretrovirus Infections / Q000097:blood / Q000276:immunology*; D006402:Hematologic Diseases / Q000097:blood / Q000276:immunology*; D006801:Humans; D007159:Immunologic Tests; D008214:Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens
Kharakteristika autoantigenov limfotsitov.