The pathology of the amyloid A4 precursor of Alzheimer's disease.
The A4 amyloid protein is the major subunit present in the amyloid of Alzheimer's disease. It is derived by proteolytic cleavage from a larger precursor (PreA4) which is a neuronal membrane glycoprotein. Whereas in Down's syndrome, over-expression of the gene coding for PreA4 is likely to be responsible for the premature development of cerebral amyloidosis, a similar mechanism is yet to be demonstrated in Alzheimer's disease.
Masters
C L
CL
Department of Pathology, University of Melbourne, Australia.
Beyreuther
K T
KT
D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000686:Amyloidosis / Q000235:genetics; D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D011956:Receptors, Cell Surface