Visual compatibility of enalaprilat with commonly used critical care medications during simulated Y-site injection.
Physical incompatibility studies between an intravenous angiotensin-converting enzyme inhibitor, enalaprilat, and potentially coadministrable ICU medications have been performed. Forty-one medications and four solutions were evaluated. The medications were anesthetic/narcotics, antibiotics, an anticoagulant, a bronchodilator, electrolyte solutions, fluids, H-2 receptor blocking agents, steroids and vasoactive agents. There was no turbidity, precipitation, or color change caused by the admixing of enalaprilat with any of the 45 agents studied. This study did not take bioavailability into consideration.
Halpern
N A
NA
Department of Surgery, Bronx VA Medical Center, NY 10468.
Colucci
R D
RD
Alicea
M
M
Greenstein
R
R
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D003422:Critical Care; D004344:Drug Incompatibility; D004656:Enalapril / Q000031:analogs & derivatives* / Q000032:analysis; D015773:Enalaprilat; D007262:Infusions, Intravenous
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D015773:Enalaprilat