title: Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry.
abstract: This study describes an investigation of the thermospray (TS) mass spectrometric analysis of tripelennamine, methapyrilene, thenyldiamine, and their N-oxide derivatives. These compounds were analyzed by direct injection TS mass spectrometry in the column bypass mode and with 0.1M ammonium acetate/methanol (80:20, v/v) as the mobile phase. Typically, the parent antihistamines produced only [MH]s ions under these conditions. The N-oxides provided strong [MH]s ions and multiple fragment ions. A scheme to explain the fragmentation patterns is proposed.
authors.affiliation: Department of Health and Human Services, National Center for Toxicological Research, Jefferson, Arkansas 72079.
authors.forename: W A
authors.initials: WA
authors.lastname: Korfmacher
authors.forename: J P
authors.initials: JP
authors.lastname: Freeman
authors.forename: E B
authors.initials: EB
authors.lastname: Hansen
authors.forename: C L
authors.initials: CL
authors.lastname: Holder
authors.forename: T A
authors.initials: TA
authors.lastname: Getek
mesh_terms: D000631:Aminopyridines / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006634:Histamine H1 Antagonists / Q000032:analysis*; D008701:Methapyrilene / Q000031:analogs & derivatives / Q000032:analysis*; D011725:Pyridines / Q000032:analysis*; D014309:Tripelennamine / Q000031:analogs & derivatives / Q000032:analysis*
chemical_list: D000631:Aminopyridines; D006634:Histamine H1 Antagonists; D011725:Pyridines; D014309:Tripelennamine; D008701:Methapyrilene; C005822:thenyldiamine