Mechanism of induction of long term potentiation by the mast cell degranulating peptide.
The properties of Long Term Potentiation (LTP), which is a sustained enhancement of the synaptic response produced by a brief train of electrical stimulation, and its mechanisms are briefly reviewed. Bath application of the mast cell degranulating peptide (MCD) - a peptide isolated from bee venom- also produces in hippocampal slices LTP which is indistinguishable from that produced by a train of electrical stimulation (no change in postsynaptic cell properties, APV sensitive). In vivo push-pull experiments indicate that this LTP is not associated with a sustained enhancement of release of glutamate and aspartate, the two principle transmitters of the hippocampus, but there is a delayed enhanced release of proteins in the extracellular space which may contribute to the maintenance of the potentiation.
Ben Ari
Y
Y
Inserm U 29, Hôpital de Port-Royal, Paris, France.
Cherubini
E
E
Aniksztejn
L
L
Roisin
M P
MP
Charriaut-Marlangue
C
C
D004558:Electric Stimulation; D006801:Humans; D010455:Peptides / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D010455:Peptides; C008331:mast cell degranulating peptide