[The effect of imipramine and trazodone on the re-uptake of (3H) serotonin by thrombocytes in patients with endogenous depression: changes in antidepressive therapy].
The inhibitory potencies of imipramine (IC50-values for IMI) and trazodone (IC50-values for TRA) on platelet [3H]serotonin uptake were measured in depressed patients. The IC50-values for IMI in patients was shown to be higher (P less than 0.01) than in controls. The IC50-values for TRA in patients were lower (P less than 0.01) than found in platelets from controls. These alterations were not accompanied by the significant decrease of a density of platelet [3H]imipramine binding sites. Drug treatment led to the normalization of the IC50-values for IMI and to the partial increase of the IC50-values for TRA. There was a negative correlation of IC50-values for TRA and severity of depressive symptoms evaluated by the Hamilton Depression Rating Scale. The results support the hypothesis that the mechanisms of the regulation of [3H]serotonin uptake sensitivity to IMI and TRA in patients are different.
Katasonow
A B
AB
Institut für Klinische Psychiatrie, Akademie der Medizinischen Wissenschaften der UdSSR.
Brusow
O S
OS
Beljaew
B S
BS
Slobina
G P
GP
Faktor
M I
MI
Larionowa
T B
TB
Trunte
K
K
Lidemann
R R
RR
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008875:Middle Aged; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000097:blood*; D014196:Trazodone / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine; D014196:Trazodone
Die Wirkung von Imipramin und Trasodon auf die Wiederaufnahme von [3H] Serotonin durch Thrombozyten von Kranken mit endogener Depression: Veränderungen während antidepressiver Therapie.