[Effect of beta-adrenergic receptors blockade on auricular natriuretic factor, aldosterone and renine blood activity during physical exercise].
Physical exercise stimulates the renin-angiotensin-aldosterone system. However several factors affect the control of mineralocorticoid secretion. In this study, eight healthy volunteers performed maximal exercise on cycle ergometer after being pretreated for 3 days with placebo (P) or with a non selective beta-blocker (B) (pindolol 15 mg/day). Plasma reinin activity (PRA), aldosterone (ALD), atrial natriuretic factor (ANF), and kalemia (K+) were measured at rest (R) and during exercise until exhaustion (E). (table; see text) These results confirm the role of beta-adrenoceptor activation in the increased PRA during exercise. It appears an exercise-induced increase in plasma ANF which was more elevated in subjects treated with pindolol, but which had no inhibitory effect on ALD secretion in theses conditions. K+ rose during exercise and this hyperkalemia tended to be higher with a beta-blocker. It is suggested that K+ elevation counterbalance both PRA decrease and ANF increase to be responsible for the absence of change in plasma ALD during beta-blockade.
Bouissou
P
P
ARPE-INSERM U 296, faculté de médecine de Créteil.
Richalet
J P
JP
Dubray
C
C
Lartigue
M
M
Aldigier
J C
JC
Habrioux
G
G
Galen
F X
FX
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D012083:Renin / Q000097:blood*
D011943:Receptors, Adrenergic, beta; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D010869:Pindolol; D012083:Renin
Effet du blocage des récepteurs beta-adrénergiques sur le facteur natriurétique auriculaire, l'aldostérone et l'activité rénine plasmatique, au cours d'un exercise physique.