Intrapituitary cell-cell communication regulates ACTH secretion.
Exposure of rat anterior pituitary cells in culture to a cytotoxin specific for CRF-target cells is followed by increased basal ACTH secretion from the remaining cells three days after the last exposure to the cytotoxin. When CRF-target-depleted populations are co-cultured with unexposed pituitary cells ACTH secretion is more than double that predicted in the absence of cell-to-cell interaction. These data provide evidence for an intrapituitary cell-to-cell signalling system modulating ACTH secretion.
Schwartz
J
J
Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.
Canny
B
B
Vale
W W
WW
Funder
J W
JW
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002478:Cells, Cultured; D003346:Corticotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D008297:Male; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D010940:Plant Proteins / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D054789:Ribosome Inactivating Proteins, Type 1
D010940:Plant Proteins; D011500:Protein Synthesis Inhibitors; D054789:Ribosome Inactivating Proteins, Type 1; C055243:corticotropin-releasing hormone, Nle(21,38)-Arg(36)-; C025674:GEL protein, Gelonium multiflorum; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone