title: Plasma ouabain-like activity in essential hypertensive patients and in subjects with primary aldosteronism.
abstract: Plasma from 37 essential hypertensive patients, from 11 subjects with primary aldosteronism and from 23 normotensive subjects was tested for ouabain-like activity. Despite a very substantial overlap, hypertensive patients (both essential and secondary) showed significantly higher levels of a ouabain-like plasma factor compared to normotensive controls. No substantial differences could be detected, however, between the two forms of hypertension; in particular, no significant changes were observed in the low-PRA subgroup. Our results are hardly compatible with the hypothesis that this substance may be of crucial importance in the development either of essential hypertension or of primary aldosteronism.
authors.affiliation: Department of Clinical Medicine, University of Verona, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Delva
authors.forename: M
authors.initials: M
authors.lastname: Degan
authors.forename: C
authors.initials: C
authors.lastname: Capra
authors.forename: F
authors.initials: F
authors.lastname: Fallo
authors.forename: F
authors.initials: F
authors.lastname: Mantero
authors.forename: M
authors.initials: M
authors.lastname: Menegazzi
authors.forename: C
authors.initials: C
authors.lastname: Lechi
authors.forename: A
authors.initials: A
authors.lastname: Steele
authors.forename: A
authors.initials: A
authors.lastname: Lechi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D012083:Renin / Q000097:blood; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D010042:Ouabain; D004077:Digoxin; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase