Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.
Willis
R C
RC
Department of Biochemistry, Nucleic Acid Research Institute, Costa Mesa, CA 92626.
Nord
L D
LD
Fujitaki
J M
JM
Breen
T S
TS
Matsumoto
S S
SS
D001402:B-Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives*; D008778:Methylthioinosine / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D011685:Purine Nucleotides / Q000096:biosynthesis / Q000378:metabolism*; D011741:Pyrimidine Nucleosides / Q000494:pharmacology*; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D012268:Ribose-Phosphate Pyrophosphokinase / Q000037:antagonists & inhibitors* / Q000378:metabolism
C011650:NSC 283867; D011685:Purine Nucleotides; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D008778:Methylthioinosine; D007288:Inosine; D010770:Phosphotransferases; D012268:Ribose-Phosphate Pyrophosphokinase