title: Relationship between computerized morphonuclear image analysis and histopathologic grading of breast cancer.
abstract: A pilot study analyzed the relationship between several morphonuclear parameters and the Bloom-Richardson score for 37 invasive, not-otherwise-specified (NOS) ductal breast carcinomas. The SAM-BA 200 cell image processor and its software were used to measure the nuclear features on Feulgen-stained imprint smears. Two parameters representing the numbers of large and dense chromatin clots and two parameters describing the heterogeneity of the chromatin among nuclei in a specimen evolved in a continuous manner parallel with the Bloom-Richardson score from stages NOS-4 to NOS-8. The systematic measurement of these four parameters on a large series of breast cancers may be able to define an objective and reproducible "scale" of differentiation that could be a helpful tool for pathologists and clinicians.
authors.affiliation: Department of Anatomic Pathology, Jules Bordet Institute, Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Larsimont
authors.forename: R
authors.initials: R
authors.lastname: Kiss
authors.forename: D
authors.initials: D
authors.lastname: d'Olne
authors.forename: Y
authors.initials: Y
authors.lastname: de Launoit
authors.forename: W
authors.initials: W
authors.lastname: Mattheiem
authors.forename: R
authors.initials: R
authors.lastname: Paridaens
authors.forename: J L
authors.initials: JL
authors.lastname: Pasteels
authors.forename: A
authors.initials: A
authors.lastname: Verhest
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D002455:Cell Division; D002467:Cell Nucleus / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D004273:DNA, Neoplasm