[Correlation of human papilloma virus (HPV) and herpes simplex virus-2 (HSV-2)in the viral etiology of carcinoma of uterine cervix].
HPV DNA and HSV-2 antigens were detected in a series of cervical lesions by DNA hybridization and PAP stain techniques in order to investigate the possible role of HPV and HSV-2 in the viral etiology of cervical carcinoma. The correlation of HPV DNA sequence and HSV-2 antigens was analyzed. The results showed that the positive rates of HPV 16, 18 and 11 in cervicitis, dysplasia and cervical cancer were 13%; 0, 13%; 17%, 17%, 17%; 43%, 8%, 4%; and HSV-2 antigens were found in 41% of cervicitis, 50% of cervical dysplasia and 63% of cervical carcinoma. Comparing the results of HPV hybridization with that of HSV-2 antigens, the authors found that both HPV DNA and HSV-2 antigens could be detected in some cases. The results indicate that the viral etiology of cervical carcinoma may be multifactorial and HSV-2 and HPV may be synergistic in the development of cervical carcinoma.
Meng
X J
XJ
Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan.
D000230:Adenocarcinoma / Q000209:etiology / Q000382:microbiology; D000956:Antigens, Viral / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006561:Herpes Simplex; D027383:Papillomaviridae / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000382:microbiology
D000956:Antigens, Viral; D004279:DNA, Viral