title: Identification of partial mutational sites in human mitochondrial DNA in the Chinese and its significance.
abstract: A simple method for the identification of mutational sites in human mitochondrial DNA (mtDNA) was described. It was based on the human Cambridge sequence as a relative standard sequence and a single base pair substitution in mtDNA as a unique mutational form. The partial mutational sites can be determined using this method which was characterized by combining the restriction mapping with the analysis for the table of human mtDNA potential mutational sites with rapidity and simplicity. In the meanwhile, six mtDNA mutational sites found in Chinese population were identified by means of this method.
authors.affiliation: Institute of Genetics, Fudan University, Shanghai.
authors.forename: M S
authors.initials: MS
authors.lastname: Yu
authors.forename: X F
authors.initials: XF
authors.lastname: Qiu
authors.forename: J L
authors.initials: JL
authors.lastname: Xue
authors.forename: Z D
authors.initials: ZD
authors.lastname: Liu
authors.forename: J Z
authors.initials: JZ
authors.lastname: Tan
authors.forename: H J
authors.initials: HJ
authors.lastname: Li
authors.forename: D X
authors.initials: DX
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: W Z
authors.initials: WZ
authors.lastname: Yu
mesh_terms: D002681:China; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D005260:Female; D006801:Humans; D008913:Minority Groups; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D004272:DNA, Mitochondrial; D015252:Deoxyribonucleases, Type II Site-Specific