Quinolone uptake by bacteria and bacterial killing.
A review of the mechanisms of the action of 4-quinolones is presented, concentrating on the process of uptake and bacterial killing. 4-Quinolones appear to cross the gram-negative outer membrane via diffusion through outer-membrane proteins, although disruption of the normal outer-membrane barrier by 4-quinolones may facilitate diffusion via a non-porin-mediated route. Accumulation in the cytoplasm may involve influx and efflux mechanisms. The inhibition of DNA synthesis by 4-quinolones has been investigated in Escherichia coli AB1157 and found to correlate with antibacterial activity (as measured by the minimal inhibitory concentration). 4-Quinolones have other pleotropic effects on bacterial cells, such as induction of the SOS (DNA repair) response, filamentation, and direct effects on membranes.
Diver
J M
JM
Microbiology Department, Dudley Road Hospital, Birmingham, England, U.K.
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D004261:DNA Replication / Q000187:drug effects; D013014:SOS Response, Genetics; D059005:Topoisomerase II Inhibitors
D042462:4-Quinolones; D000890:Anti-Infective Agents; D059005:Topoisomerase II Inhibitors