Human liver and plasma aspirin esterase.
The plasma, in addition to the liver, is a major site of hydrolysis of aspirin. Human plasma and liver aspirin esterase activities in samples from a group of patients varied over a two fold range and there was a significant correlation between individual plasma and liver activities. Human liver aspirin esterase was present in the cytosolic and microsomal fractions. Cytosolic and microsomal enzymes had different activities and apparent affinities for aspirin.
Williams
F M
FM
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, UK.
Mutch
E M
EM
Nicholson
E
E
Wynne
H
H
Wright
P
P
Lambert
D
D
Rawlins
M D
MD
D000368:Aged; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003600:Cytosol / Q000201:enzymology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D013347:Subcellular Fractions / Q000201:enzymology
D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase