Clobazam increases pulsatile luteinizing hormone secretion in normal men.
To investigate the effects of the 1,5-benzodiazepine, clobazam, on LH secretion in normal men, LH pulsatile secretion was defined after oral administration of 40 mg of clobazam or a placebo to 6 healthy male volunteers, according to a randomized cross-over design. LH pulse frequency increased significantly from a mean of 3.8 (range 3-5) pulses/8 h after placebo, to a mean of 5 (range 4-7) pulses/8 h (P less than 0.05), after clobazam. Mean LH concentrations and peak amplitudes did not change significantly. These results suggest that clobazam mediates its effects on LH secretion at the hypothalamic level by increasing the frequency of episodic GnRH release.
Thomas
G
G
Unité de Pharmacologie Clinique, Hôpital Fernand Widal, Paris, France.
Thalabard
J C
JC
Duet
M
M
Girre
C
C
Fournier
P E
PE
D000328:Adult; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000493:pharmacokinetics / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D000078306:Clobazam; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011897:Random Allocation
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam; D007986:Luteinizing Hormone