MEN-2 tumor associations suggest a linear order of specific endocrine tumor genes.
The variation in tumor involvement between families and consistent pattern within 12 MEN-2A and 4 MEN-2B families studied suggest that the tumors in MEN-2 result from separate, specific mutations in a specific linear order of adjacent genes.
Jackson
C E
CE
Department of Medicine, Henry Ford Hospital, Detroit, Michigan.
Van Dyke
D L
DL
Talpos
G B
GB
Norum
R A
RA
Tashjian
A H
AH
D002874:Chromosome Mapping; D052138:Genes, Neoplasm; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*