Effects of intradermal gamma-interferon in cutaneous leishmaniasis.
The clinical and immunological evolution of lesions in cutaneous leishmaniasis was assessed after treatment with human recombinant gamma interferon (rIFN-gamma). 3 weeks after rIFN-gamma treatment of lesions due to Leishmania braziliensis guyanensis, 12/13 had become smaller compared with 6/13 control lesions; only 4 treated lesions were free of parasites. 9 of 13 L tropica lesions treated with rIFN-gamma resolved completely within 4-8 weeks of treatment. An acute inflammatory reaction around treated lesions was more common in lesions due to L tropica. There were no other local or systemic adverse reactions. Histological and immunohistochemical studies indicate that local application of rIFN-gamma enhances cell-mediated immune responses and thus promotes healing of cutaneous leishmaniasis.
Harms
G
G
Landesinstitut für Tropenmedizin, Berlin, Federal Republic of Germany.
Zwingenberger
K
K
Chéhadé
A K
AK
Talhari
S
S
Racz
P
P
Mouakeh
A
A
Douba
M
M
Näkel
L
L
Naiff
R D
RD
Kremsner
P G
PG
D000208:Acute Disease; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D001706:Biopsy; D001938:Brazil; D002986:Clinical Trials as Topic; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007892:Leishmania braziliensis / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology; D013593:Syria; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000913:Antibodies, Protozoan; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; D007073:Immunoglobulin E; D007371:Interferon-gamma