title: Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone.
abstract: The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1-29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.
authors.affiliation: Istituto di Endocrinologia e di Ematologia, Università di Sassari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Delitala
authors.forename: P A
authors.initials: PA
authors.lastname: Tomasi
authors.forename: M
authors.initials: M
authors.lastname: Palermo
authors.forename: R J
authors.initials: RJ
authors.lastname: Ross
authors.forename: A
authors.initials: A
authors.lastname: Grossman
authors.forename: G M
authors.initials: GM
authors.lastname: Besser
mesh_terms: D000328:Adult; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D011957:Receptors, Opioid; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone