In vitro sensitivity of human herpesvirus-6 to antiviral drugs.
We studied the sensitivity of human herpesvirus-6 (HHV-6) to 4 antiviral drugs known to be effective in the treatment of infections with other human herpesviruses and human immunodeficiency virus. HHV-6 was grown in peripheral blood lymphocytes, and virus multiplication was quantified by evaluation of the cytopathic effect by molecular hybridization and indirect immunofluorescence assay. The 50% and 90% inhibitory concentrations (IC50 and IC90) were determined for each drug. The results obtained by the 3 different quantification techniques were found to correlate, and enabled us to conclude that HHV-6 replication was readily inhibited by foscarnet or ganciclovir. In contrast, inhibition of HHV-6 replication was observed only at high concentrations of acyclovir, and was not detected at the tested concentrations of zidovudine.
Agut
H
H
Laboratoire de Bactériologie-Virologie, CERVI, Hôpital de la Pitié-Salpêtrière, Paris.
Collandre
H
H
Aubin
J T
JT
Guétard
D
D
Favier
V
V
Ingrand
D
D
Montagnier
L
L
Huraux
J M
JM
D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral; D004305:Dose-Response Relationship, Drug; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000998:Antiviral Agents