title: Microvascular response to locally injected collagenase. An experimental investigation in hamsters and rabbits.
abstract: Collagenase was injected into the ears of rabbits and the cheek-pouches of hamsters. The acute and long-term microvascular effects were studied by vital microscopy and microangiography. The enzyme was injected at three different concentrations: 120 units/ml, 600 units/ml and 3,000 units/ml. The medium (600 units/ml) and high (3,000 units/ml) concentrations induced effects on the microcirculation such as blood flow impairment and microbleedings. The magnitude of these effects was related to the concentration of the enzyme. Generally, these microvascular effects were of low magnitude as compared with other substances tested using the same experimental models.
authors.affiliation: Department of Orthopaedics, Gothenburg University, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Rydevik
authors.forename: T
authors.initials: T
authors.lastname: Ehira
authors.forename: L
authors.initials: L
authors.lastname: Linder
authors.forename: K
authors.initials: K
authors.lastname: Olmarker
authors.forename: M
authors.initials: M
authors.lastname: Romanus
authors.forename: P I
authors.initials: PI
authors.lastname: Brånemark
mesh_terms: D000818:Animals; D002610:Cheek / Q000098:blood supply / Q000187:drug effects; D002921:Cicatrix; D006224:Cricetinae; D004431:Ear, External / Q000098:blood supply / Q000187:drug effects; D007279:Injections, Subcutaneous; D008647:Mesocricetus; D003012:Microbial Collagenase / Q000008:administration & dosage* / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects*; D011817:Rabbits; D012039:Regional Blood Flow
chemical_list: D003012:Microbial Collagenase