title: Increased chromosomal radiosensitivity in patients undergoing radioimmunoglobulin therapy.
abstract: Lymphocytes from individual patients undergoing radiolabeled immunoglobulin therapy have been examined both for chromosome aberrations expressed immediately upon explant, or for chromosome aberrations induced by a subsequent challenge of gamma-rays after PHA-stimulated proliferation. Despite interpatient variation, there is strong correlation between levels of chromosome aberrations observed in the initial mitosis after mitogenic stimulation and levels induced by a challenge dose of radiation in replicate cultures after several cell cycles of growth. These data indicated that even after proliferation, human lymphocytes retain a memory of in vivo exposure to ionizing radiation that can be observed by challenge with a clastogenic agent. This persistent hypersensitivity occurs at high frequency, suggesting that it may be related to initial steps in multistage carcinogenesis.
authors.affiliation: Radiobiology Laboratory, Johns Hopkins University Oncology Center, Baltimore, MD 21205.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Xiao
authors.forename: D
authors.initials: D
authors.lastname: Jacobson-Kram
authors.forename: S
authors.initials: S
authors.lastname: Piantadosi
authors.forename: J R
authors.initials: JR
authors.lastname: Williams
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D005293:Ferritins / Q000276:immunology; D005720:Gamma Rays; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000532:radiotherapy; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D011836:Radiation Tolerance
chemical_list: D007136:Immunoglobulins; D007457:Iodine Radioisotopes; D005293:Ferritins