ADH secretion in schizophrenic patients on antipsychotic drugs.
The authors studied antidiuretic hormone (ADH) secretion in schizophrenics on antipsychotic drugs. The mean plasma level of ADH is lower among schizophrenics than among controls at comparable values of plasma osmolality. In regression analysis of the relationship between plasma ADH and plasma osmolality, the slope of the regression line is gentler and the threshold of ADH secretion is lower in schizophrenics than that in control subjects. The authors suggest that the relationship between plasma ADH and plasma osmolality may be different in schizophrenics receiving antipsychotic drugs than in controls.
Sarai
M
M
Kosaka Hospital, Higashi-Osaka, Japan.
Matsunaga
H
H
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002746:Chlorpromazine / Q000009:adverse effects; D004326:Drinking / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D014667:Vasopressins / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D014150:Antipsychotic Agents; D014667:Vasopressins; D002746:Chlorpromazine