The distribution of beta-adrenoceptors in human cervix.
The distribution of beta-adrenoceptors in sections of human cervix taken at the proliferative phase of the menstrual cycle was studied using light-microscopic autoradiography. The radioligand [125I]iodocyanopindolol (125ICYP) was used to identify specific binding sites. Moderate density of labelling by 125ICYP was seen over smooth muscle and blood vessels. The most intense labelling, however, was seen over glands and surface columnar epithelium. The association of beta-adrenoceptors with glands and surface columnar epithelium suggests a possible adrenergic regulation of secretory function in the cervix.
Whitaker
E M
EM
Department of Physiology, University of Leeds.
Nimmo
A J
AJ
Morrison
J F
JF
Griffin
N R
NR
Wells
M
M
D001345:Autoradiography; D015784:Betaxolol / Q000378:metabolism; D001665:Binding Sites; D002584:Cervix Uteri / Q000378:metabolism*; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D011412:Propanolamines / Q000378:metabolism; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C026777:ICI 118551; D015784:Betaxolol