title: Peripheral nervous system involvement in essential cryoglobulinemia and nephropathy.
abstract: The clinical and neurophysiological features of 23 patients affected by essential cryoglobulinemia (EC) have been studied. It was possible to perform sural nerve biopsy in 3 cases. Six patients were found to be affected by a peripheral neuropathy, according to the WHO criteria, while in 8 other patients clinical and neurophysiological signs of a milder peripheral nervous system (PNS) involvement were evident. The incidence of PNS involvement seems to be high (60.9%). Neurophysiological and histological studies were indicative of a mainly axonal damage.
authors.affiliation: Division of Nephrology, Maggiore Hospital, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Valli
authors.forename: A
authors.initials: A
authors.lastname: De Vecchi
authors.forename: L
authors.initials: L
authors.lastname: Gaddi
authors.forename: E
authors.initials: E
authors.lastname: Nobile-Orazio
authors.forename: A
authors.initials: A
authors.lastname: Tarantino
authors.forename: S
authors.initials: S
authors.lastname: Barbieri
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D003449:Cryoglobulinemia / Q000150:complications*; D003711:Demyelinating Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000502:physiology; D012026:Reflex, Stretch / Q000502:physiology; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology