Synthesis of some 2-(3,4-dimethoxy-phenyl)-1,3-propanediamines as potential dopaminergic agents.
The bilateral diamino analogs namely N,N'-dialkyl-N,N'-diaralkyl- and N,N,N',N'-tetraalkyl-2-(3,4-dimethoxyphenyl)-1,3-propanediamine s were synthesized. The biochemical determination of the brain levels of dopamine and norepinephrine as well as of brain monoamine oxidase (MAO) activity was performed.
Shafik
R M
RM
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria.
Ibrahim
E A
EA
el-Khawass
E M
EM
el-Hawash
S A
SA
el-Dardiry
S A
SA
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000138:chemical synthesis*; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008787:Metoclopramide / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D003959:Diamines; D015259:Dopamine Agents; D008995:Monoamine Oxidase; D008787:Metoclopramide; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine