title: Non-occupational malignant mesotheliomas.
abstract: The mineral content of the lungs from 84 cases of malignant pleural mesothelioma was estimated by electron microscopy and energy-dispersive X-ray analysis. These cases were chosen because the history of asbestos exposure was absent, indirect or ill-defined. The occupational exposures were classified according to the method of Zielhuis, and the results indicated that this classification is unnecessarily complicated. The chrysotile counts in the lungs from these mesothelioma cases were similar to those in controls and in a previous series of mesotheliomas in which the majority had had direct exposure to asbestos. Amphibole counts were intermediate between those in controls and in the previous series of mesotheliomas with direct asbestos exposure. These findings confirm those of previous studies indicating that amphiboles are more important than chrysotile in the causation of malignant mesothelioma. The results confirm that some mesotheliomas develop in the absence of asbestos exposure.
authors.affiliation: Department of Pathology, Llandough Hospital, Penarth, South Glamorgan, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Gibbs
authors.forename: J S
authors.initials: JS
authors.lastname: Jones
authors.forename: F D
authors.initials: FD
authors.lastname: Pooley
authors.forename: D M
authors.initials: DM
authors.lastname: Griffiths
authors.forename: J C
authors.initials: JC
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000032:analysis*; D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis*; D008297:Male; D008654:Mesothelioma / Q000032:analysis* / Q000209:etiology / Q000648:ultrastructure; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000032:analysis* / Q000209:etiology / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000032:analysis
chemical_list: D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D001194:Asbestos; D012822:Silicon Dioxide