title: [Continuous arterial infusion therapy of recombinant interleukin-2 and cyclophosphamide in hepatoma and liver metastasis].
abstract: The continuous arterial infusion of only recombinant interleukin-2 (rIL-2) was used in 9 patients with unresectable liver metastasis of colorectal or biliary cancer. This therapy was undertaken for the activation of tumor infiltrating lymphocytes (TIL), but was not effective. Then we tried continuous arterial infusion of rIL-2 and low-dose cyclophosphamide (CY) for liver metastasis. 3 of the patients who received rIL-2 and CY showed partial remission of disease. This therapy was possibly effective because of the activation of TIL and the suppression of tumor infiltrating suppressor lymphocytes.
authors.affiliation: Dept. of Surgery, Hirosaki University Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Fukushima
authors.forename: D
authors.initials: D
authors.lastname: Seito
authors.forename: Y
authors.initials: Y
authors.lastname: Asakura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Konn
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D007376:Interleukin-2 / Q000008:administration & dosage* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000628:therapy*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins; D003520:Cyclophosphamide