Synthesis of imidazo[4,5-d][1,3]thiazine ribosides and related compounds of biological interest.
Several tri-O -acetyl-1-beta-D -ribofuranosyl- and 2-acetoxyethoxymethylimidazo[4,5-d][1,3]thiazine derivatives 5-10 were synthesized from imidazo[4,5-d][1,3]thiazine 4 and tetra-O -acetyl-beta-D -ribofuranose or 2-acetoxyethoxymethyl acetate by fusion method. In each case, depending on the substituent on position 5 of thiazine skeleton, only N3 isomer or both N1 and N3 isomers (in different ratios) were obtained.
Kaneko
C
C
Minophargen Research Laboratory, Kanagawa, Japan.
Matsumoto
H
H
Hara
S
S
Takeuchi
T
T
Mori
T
T
Ikeda
K
K
Mizuno
Y
Y
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis*; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D000212:Acyclovir