Electroencephalographic study of naloxone effects in the recovery of an acute alcoholic intoxication.
Experimental assays analysing EEG changes during the recovery of an acute alcoholic intoxication were carried out in three groups of cats: 1) Recovery of acute alcoholic intoxication produced by continuous intravenous perfusion of ethanol, 0.06 g/kg/min, during 20 minutes. 2) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), just after finishing alcohol perfusion. 3) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), 15 min after finishing perfusion. Naloxone administered after an acute alcoholic intoxication worsens the recovery of EEG parameters; 1-2 (p less than 0.05), 1-3 (p less than 0.05).
Dawid-Milner
M S
MS
Departamento de Fisiologia Humana, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Díaz-Calavia
E J
EJ
Lara
J P
JP
Fernández del Moral
R
R
Jiménez-Vargas
J
J
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002415:Cats; D004357:Drug Synergism; D004569:Electroencephalography; D004723:Endorphins / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D017450:Receptors, Opioid, mu
D004723:Endorphins; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; D000431:Ethanol