Lower autolytic activity in a homogeneous methicillin-resistant Staphylococcus aureus strain compared to derived heterogeneous-resistant and susceptible strains.
It has been proposed that in addition to production of a penicillin-binding protein with low affinity for beta-lactam antibiotics, control of autolysin activity is involved in the mechanism of staphylococcal methicillin resistance. A homogeneous methicillin-resistant Staphylococcus aureus strain (DU4916) had lower rates of unstimulated, NaCl- and Triton X-100-stimulated autolysis, and daptomycin (LY146032)-induced lysis than a heterogeneous methicillin-resistant strain (DU4916-K7) and a methicillin-susceptible strain (DU4916S) derived from DU4916.
Gustafson
J E
JE
Department of Biological Sciences, Illinois State University, Normal, IL.
Wilkinson
B J
BJ
D001433:Bacteriolysis; D017576:Daptomycin; D008712:Methicillin / Q000494:pharmacology*; D017830:Octoxynol; D010403:Penicillin Resistance; D010455:Peptides / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology*
D010455:Peptides; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D017830:Octoxynol; D017576:Daptomycin; D008712:Methicillin