title: Decreased melatonin concentration in Cushing's syndrome.
abstract: To determine the effect of hypercortisolaemia on the melatonin circadian secretion 12 patients with pituitary or adrenal dependent Cushing's syndrome and 5 healthy controls were studied. The melatonin circadian rhythm of secretion, observed in the control group, was abolished in the patients with hypercortisolaemia. Mean nocturnal melatonin levels and the integrated 24-hour secretion were significantly lower in the patients studied than those of the controls. Thus, in patients with Cushing's syndrome the melatonin levels are decreased and the circadian rhythm of this hormone is abolished.
authors.affiliation: Department of Endocrinology, Medical Center for Postgraduate Education, Warsaw, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Soszyński
authors.forename: J
authors.initials: J
authors.lastname: Stowińska-Srzednicka
authors.forename: A
authors.initials: A
authors.lastname: Kasperlik-Zatuska
authors.forename: S
authors.initials: S
authors.lastname: Zgliczyński
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000097:blood; D000236:Adenoma / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D003480:Cushing Syndrome / Q000097:blood* / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications
chemical_list: D015065:17-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D008550:Melatonin; D006854:Hydrocortisone