[The current situation of mycobacterial chemoresistance and its implications for antitubercular treatment].
The data in the present paper consider, for a longer period, the secondary and the initial drug resistance in pulmonary and extrapulmonary tuberculosis. The paper studies mainly the period of the last 9 years (1979-1987) in comparison with a previous period of 6 years (1973-1978). The 2,194 antibiograms performed for 7 common tuberculostatics show an increase, in the last years, of the general resistance of the germs from 24.3% to 36%. The increase of the resistance is noticed to all the tuberculostatics, but mainly to Rifampicin, from 14.8% to 49.3% and to streptomycin, from 22.7% to 44.8%. An important increase is found, at present, mainly in the drug resistance of germs in the extrapulmonary specimens (lymph nodes 28.5% and CSF 40%) to streptomycin and INH.
Jemna
I
I
Cioflec
D
D
Ion
N
N
Hudiţeanu
O
O
Lego
I
I
Simon
I
I
D000995:Antitubercular Agents / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D013997:Time Factors
D000995:Antitubercular Agents
Situaţia actuală a chimiorezistenţei micobacteriene şi implicaţiile acesteia asupra tratamentului antituberculos.