title: Slow recovery of central axons in acrylamide neuropathy.
abstract: To study the differential vulnerability of central versus peripheral axons, we observed serial changes in conduction over comparable segments of central and peripheral axons of the primary sensory neuron in 17 rats with acrylamide neuropathy using somatosensory evoked potentials. Central conduction abnormalities persisted even after peripheral conduction and clinical abnormalities had recovered. Morphometric studies showed prompt restoration of the largest-diameter fibers in the peripheral nerve after clinical recovery but persistent or even more severe loss of large- and medium-sized fibers in the cervical gracile tract. This finding suggests that recovery from central-peripheral distal axonopathy begins in the largest peripheral axons, perhaps even at the expense of central axons, and that clinical recovery can occur at a time when central conduction remains abnormal. The selective central axonopathy found in certain chronic degenerative disorders may be a consequence of this slow central recovery process associated with chronic or intermittent metabolic derangements.
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia.
authors.forename: R
authors.initials: R
authors.lastname: Kaji
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Duckett
authors.forename: A J
authors.initials: AJ
authors.lastname: Sumner
mesh_terms: D000178:Acrylamides / Q000009:adverse effects*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory; D008297:Male; D010525:Peripheral Nerves / Q000187:drug effects / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000178:Acrylamides