[Effect of carbidine on parameters of ethanol oxidation in experimental alcoholic intoxication].
The effect of carbidine on enzymes of ethanol and acetaldehyde oxidation, the rate of ethanol elimination and the parameters of ethanol consumption were studied during long-term alcoholic intoxication. Carbidine administration was shown to increase the activity of alcohol dehydrogenase of the liver tissue, to decrease the activity of aldehyde dehydrogenase with a low Km to acetaldehyde. Also, the rate of ethanol elimination and a relative amount of consumed ethanol increase at the expense of an increase of the volume of consumed liquid.
Gurtovenko
V M
VM
Kuznetsova
N I
NI
Shumaĭlov
I N
IN
Proskuriakova
T V
TV
Eremina
R V
RV
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D002243:Carbolines; D000431:Ethanol; D000426:Alcohol Dehydrogenase; C100106:dicarbine
O vliianii karbidina na pokazateli okisleniia étanola pri éksperimental'noĭ alkogol'noĭ intoksikatsii.