[Preliminary study on the virulent difference between viral strains isolated from Rattus norvegicus and Apodemus agrarius in Fujian Province].
Virulence between virus strains of hemorrhagic fever with renal syndrome (HFRS) from R. norvegicus and A. agrarius were different, besides the diversity in their epidemiological feature, clinical symptoms and antigenicity. Virulence of the virus strains from R. norvegicus, especially those from nonepidemic areas, were weak than those from A. agrarius. Sucking mice might be used for determining virulence of the virus strains from various source. Foci of HFRS had been in southern Fujian, but human cases of HFRS had rarely been found, or only a few mild cases were found in a few areas. This might be related to weaker virulence of the virus strains from R. norvegicus. The prevalent degree of the disease might be related to HFRSV of wild rattus type in the area.
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D000818:Animals; D002681:China; D006476:Orthohantavirus / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D051379:Mice; D009115:Muridae / Q000382:microbiology*; D051381:Rats / Q000382:microbiology*; D014774:Virulence