Adrenergic mediated phosphatidylinositol metabolism is modulated by epileptic discharges in human neocortex.
Adrenergic mediated phosphatidylinositol (PI) hydrolysis was measured in tissues obtained from 21 patients immediately following surgery for focal epilepsy. Accumulation of [3H]inositol monophosphate (IP1) was significantly reduced (21%, P less than 0.01) in actively spiking neocortex (n = 15) versus samples from non-spiking regions (n = 9). Epileptic discharges may blunt alpha 1-adrenoceptor stimulated transmembrane signalling in human neocortical epileptic foci.
Dubeau
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Montreal Neurological Institute, McGill University, Que, Canada.
Sherwin
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D000200:Action Potentials / Q000187:drug effects; D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D004837:Epinephrine