title: Metal complexes of antiinflammatory drugs. Part VII: Salsalate complex of copper(II).
abstract: The preparation and properties of the Cu(II) complex Cu(SAS)2.H2O are reported for the antiinflammatory drug Salsalate (SAS). The diffuse reflectance spectra and magnetic moments are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The Cu(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
authors.affiliation: Department of Chemistry, University College of North Wales, Bangor, United Kingdom.
authors.forename: A E
authors.initials: AE
authors.lastname: Underhill
authors.forename: A
authors.initials: A
authors.lastname: Bury
authors.forename: R J
authors.initials: RJ
authors.lastname: Odling
authors.forename: M B
authors.initials: MB
authors.lastname: Fleet
authors.forename: A
authors.initials: A
authors.lastname: Stevens
authors.forename: P S
authors.initials: PS
authors.lastname: Gomm
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000032:analysis*; D008280:Magnetics; D012459:Salicylates / Q000032:analysis*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D013481:Superoxides; D003300:Copper; D013482:Superoxide Dismutase; C014182:salicylsalicylic acid