title: One receptor type mediates two independent effects of FMRFa on neurosecretory cells of Lymnaea.
abstract: Structure activity relations (SAR) of FMRFa on the transient hyperpolarizing response and long lasting depression of excitability of neurosecretory caudo dorsal cells (CDCs) of the pond snail Lymnaea stagnalis were examined. Although these effects to FMRFa occur independently, the SARs for the induction of both responses were identical suggesting that CDCs possess a single type of FMRFa receptors. Native GDPFLRFa and SDPFLRFa were equipotent to FMRFa receptors. It is concluded that activation of the receptor requires [Arg3-Phe4]-NH2, whereas N-terminal amino acids are involved in binding.
authors.affiliation: Department of Biology, Free University, Amsterdam, The Netherlands.
authors.forename: A B
authors.initials: AB
authors.lastname: Brussaard
authors.forename: K S
authors.initials: KS
authors.lastname: Kits
authors.forename: A
authors.initials: A
authors.lastname: ter Maat
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D019835:FMRFamide; D008195:Lymnaea; D009479:Neuropeptides / Q000494:pharmacology*; D009490:Neurosecretory Systems / Q000187:drug effects / Q000502:physiology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D018010:Receptors, Invertebrate Peptide; D013329:Structure-Activity Relationship
chemical_list: C055209:FMRFamide receptor; D009479:Neuropeptides; D009842:Oligopeptides; D011956:Receptors, Cell Surface; D018010:Receptors, Invertebrate Peptide; D019835:FMRFamide