[Inhibition of proliferation of normal and neoplastic liver cells under conditions of prolonged hormonal stimulation].
Single injections of rats with hydrocortisone led to the inhibition of regenerating liver cell proliferation and protooncogene++ Ha-ras mRNA synthesis within 48 hours of hormonal induction. Administration of hydrocortisone to rats daily for 10 days resulted in a persistent decrease of the liver cell capacity to proliferate in response to partial hepatectomy. This inhibiting effect was observed for at least 7 days after cessation of hormonal stimulation; the level of Ha-ras mRNA was thereby decreased. A marked inhibition of ascite hepatoma cell growth was demonstrated after injections of those cells to mice induced with hydrocortisone for 10 days. Such a persistent effect of hydrocortisone is thought to be due to the depletion of the hormone-dependent hepatotrophic factors. The effect of the glucocorticoid hormone in vivo can be supposed to involve both the direct and indirect regulation of target cell proliferation. The latter is mediated via the changes in the activity of exogenous factors which control cell growth and proliferation.
Krasil'nikov
M A
MA
Bogdanova
N N
NN
Adler
V V
VV
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006498:Hepatectomy; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects; D014444:Tyrosine Transaminase / Q000378:metabolism
D012333:RNA, Messenger; D014444:Tyrosine Transaminase; D006854:Hydrocortisone
Tormozhenie proliferatsii normal'nykh i opukholevykh kletok pecheni v usloviiakh dlitel'noĭ gormonal'noĭ stimuliatsii.