title: Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
abstract: The enantiomers of 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8- amine (1a) were prepared and tested for their actions on central dopamine and serotonin (5-HT) receptors. The dopaminergic effects were shown to reside in the (1)-R enantiomer. It was shown that compound 1a and its (+)-R enantiomer possess potent central 5-HT1A receptor stimulating properties.
authors.affiliation: Department of Pharmacology, University of Göteborg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Wikström
authors.forename: B
authors.initials: B
authors.lastname: Andersson
authors.forename: A
authors.initials: A
authors.lastname: Svensson
authors.forename: L G
authors.initials: LG
authors.lastname: Humber
authors.forename: A A
authors.initials: AA
authors.lastname: Asselin
authors.forename: K
authors.initials: K
authors.lastname: Svensson
authors.forename: A
authors.initials: A
authors.lastname: Ekman
authors.forename: A
authors.initials: A
authors.lastname: Carlsson
authors.forename: I
authors.initials: I
authors.lastname: Nilsson
authors.forename: C
authors.initials: C
authors.lastname: Chidester
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D015259:Dopamine Agents / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D007536:Isomerism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D015259:Dopamine Agents; D007211:Indoles; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; C061237:6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz(e)indol-8-amine; D012110:Reserpine