The neu (c-erbB-2) oncogene.
The neu gene was first identified in rat tumors that had been induced by the carcinogen ethyl nitrosourea. The human homolog of neu, usually designated c-erbB-2, is located on chromosome 17, q21. It specifies a transmembrane receptor-like phosphoglycoprotein that is closely related to the EGFr (c-erbB-1). The ligand for c-erbB-2 is not known. A significant proportion of adenocarcinomas (especially of the breast, colon, and pancreas) have amplification and/or overexpression of c-erbB-2. The unique qualities associated with the subset of tumors that overexpress c-erbB-2 have not yet been firmly identified.
Maguire
H C
HC
Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia 19104-6082.
Greene
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MI
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005038:Ethylnitrosourea; D005784:Gene Amplification; D006801:Humans; D051379:Mice; D009447:Neuroblastoma / Q000139:chemically induced / Q000235:genetics / Q000628:therapy; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000276:immunology; D051381:Rats; D018719:Erb-b2 Receptor Tyrosine Kinases
D000911:Antibodies, Monoclonal; D005038:Ethylnitrosourea; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases