title: Viral etiology of cervical carcinoma. Human papilloma virus and herpes simplex virus type 2.
abstract: The possible role of human papilloma virus (HPV) and herpes simplex virus type 2 (HSV-2) in the viral etiology of cervical carcinoma was investigated a series of cervical lesions were studied for the presence of HPV and HSV-2 DNA sequences as well as HPV and HSV-2 antigens by DNA dot blot hybridization technique and high-specificity PAP staining method. The results obtained were correlated with the histologic diagnosis. HPV 16 DNA sequences detected in cervical carcinoma biopsies were 43%, whereas HSV-2 DNA sequences were only 8%. HPV antigens detected in cervical dysplasia were 31%, whereas those detected in cervical carcinoma and cervicitis were the least. HSV-2 antigens were detected in chronic cervicitis, dysplasia and cervical carcinoma. The difference in positive rate between the cervical carcinoma and cervicitis groups was statistically significant, (chi-square test, P less than 0.01). No HPV DNA and HSV-2 DNA sequences were found in the same specimen, although both HPV DNA sequences and HSV-2 antigens were found in the same sample in some cases. The results indicate that the viral etiology of cervical carcinoma may be multifactorial. Both HSV-2 and HPV may be associated with cervical carcinoma, but the mechanisms involved are different. HSV-2 and HPV may act synergistically in the development of cervical carcinoma.
authors.forename: X J
authors.initials: XJ
authors.lastname: Meng
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: Z H
authors.initials: ZH
authors.lastname: Liu
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Li
authors.forename: R C
authors.initials: RC
authors.lastname: Han
authors.forename: J Y
authors.initials: JY
authors.lastname: Si
authors.forename: L Y
authors.initials: LY
authors.lastname: Hu
mesh_terms: D000957:Antigens, Viral, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000382:microbiology; D002584:Cervix Uteri / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000382:microbiology
chemical_list: D000957:Antigens, Viral, Tumor; D004279:DNA, Viral