Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.
A strain of Streptoverticillium cinnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-beta-hydroxyaspartic acid, mesolanthionine, threo-beta-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.
Naruse
N
N
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Tenmyo
O
O
Tomita
K
K
Konishi
M
M
Miyaki
T
T
Kawaguchi
H
H
Fukase
K
K
Wakamiya
T
T
Shiba
T
T
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002850:Chromatography, Gel; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic; D018139:Simplexvirus / Q000187:drug effects*; D012988:Soil Microbiology; D012995:Solubility; D013171:Spores, Bacterial; D013306:Streptomycetaceae / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D014709:Vero Cells
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D010455:Peptides; D010456:Peptides, Cyclic; C055996:lanthiopeptin