title: Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection.
abstract: To examine whether cytomegalovirus (CMV) infection could accelerate progression of human immunodeficiency virus (HIV) infection to AIDS, serological studies were done on 108 HIV-infected haemophiliacs. In the 1.3-9 years from time of first recognised HIV seroconversion, the age-adjusted risk of CDC group IV disease in CMV-seropositive patients was 2.5 times that in CMV-seronegative patients. CMV-seropositive patients were also more likely to have detectable p24 antigenaemia. Survival analysis showed that CMV-seropositive patients were at greater risk of HIV disease than CMV-seronegative patients from about 2 years after HIV seroconversion. Thus CMV infection is associated with a more rapid progression to HIV disease.
authors.affiliation: Department of Virology, Royal Free Hospital, School of Medicine, London.
authors.forename: A
authors.initials: A
authors.lastname: Webster
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
authors.forename: D G
authors.initials: DG
authors.lastname: Cook
authors.forename: J E
authors.initials: JE
authors.lastname: Grundy
authors.forename: V C
authors.initials: VC
authors.lastname: Emery
authors.forename: P B
authors.initials: PB
authors.lastname: Kernoff
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D014775:Virus Activation