Changes in the superoxide anion generating capacity and respiratory burst enzymes of peripheral blood monocytes of monkeys during acute Plasmodium knowlesi infection.
The superoxide anion generation profile of peripheral blood monocytes of rhesus monkeys was investigated during the different stages of an acute Plasmodium knowlesi infection. An initial increase in superoxide anion was followed by a significant decline (P less than 0.001), paralleled by a drop in NADPH oxidase activity; there was no alteration in the activity of the hexose monophosphate shunt enzymes. This lowered activity of the NADPH oxidase, with the resulting decreased O2 generation, might be responsible for the failure of the animals to control the parasitaemia; as a result they succumbed to the infection.
Jayshree
R S
RS
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Sethi
A K
AK
Mahajan
R C
RC
D000818:Animals; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D008253:Macaca mulatta; D008288:Malaria / Q000097:blood*; D009000:Monocytes / Q000201:enzymology / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000097:blood; D019255:NADPH Oxidases; D010734:Phosphogluconate Dehydrogenase / Q000097:blood; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases