title: Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
abstract: In prior studies, nerve growth factor (NGF) administration induced a robust, selective increase in the neurochemical differentiation of caudate-putamen cholinergic neurons. In this study, expression of NGF and its receptor was examined to determine whether endogenous NGF might serve as a neurotrophic factor for these neurons. The temporal pattern of NGF gene expression and the levels of NGF mRNA and protein were distinct from those found in other brain regions. NGF and high-affinity NGF binding were present during cholinergic neurochemical differentiation and persisted into adult-hood. An increase in NGF binding during the third postnatal week was correlated with increasing choline acetyltransferase activity. The data are consistent with a role for endogenous NGF in the development and, possibly, the maintenance of caudate-putamen cholinergic neurons.
authors.affiliation: Department of Neurology, University of California, San Francisco 94143.
authors.forename: W C
authors.initials: WC
authors.lastname: Mobley
authors.forename: J E
authors.initials: JE
authors.lastname: Woo
authors.forename: R H
authors.initials: RH
authors.lastname: Edwards
authors.forename: R J
authors.initials: RJ
authors.lastname: Riopelle
authors.forename: F M
authors.initials: FM
authors.lastname: Longo
authors.forename: G
authors.initials: G
authors.lastname: Weskamp
authors.forename: U
authors.initials: U
authors.lastname: Otten
authors.forename: J S
authors.initials: JS
authors.lastname: Valletta
authors.forename: M V
authors.initials: MV
authors.lastname: Johnston
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000378:metabolism; D011699:Putamen / Q000254:growth & development / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor
chemical_list: D009414:Nerve Growth Factors; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor