title: Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements.
abstract: The Rex regulatory proteins of human T-cell leukemia virus type I (HTLV-I) and bovine leukemia virus (BLV), and the Rev protein of human immunodeficiency virus type 1 (HIV-1), promote the cytoplasmic accumulation and translation of viral messenger mRNAs encoding structural proteins. Rev and Rex act through cis-acting elements on the viral RNA; these elements are named Rev- and Rex-responsive elements, or RRE and RXRE, respectively. We show that the Rex proteins of HTLV-I and BLV are interchangeable, but only the Rex protein of HTLV-I can substitute for Rev of HIV-1. Rex of HTLV-I and Rev of HIV-1 appear to act on RRE by similar mechanisms. Rev of HIV-1 does not act on the RXRE of HTLV-I or BLV. The nonreciprocal action of Rev and Rex suggests that these factors interact directly with the cis-acting RNA elements of the two viruses.
authors.affiliation: Frederick Cancer Research Facility BRI-Basic Research Program, MD 21701-1013.
authors.forename: B K
authors.initials: BK
authors.lastname: Felber
authors.forename: D
authors.initials: D
authors.lastname: Derse
authors.forename: A
authors.initials: A
authors.lastname: Athanassopoulos
authors.forename: M
authors.initials: M
authors.lastname: Campbell
authors.forename: G N
authors.initials: GN
authors.lastname: Pavlakis
mesh_terms: D000818:Animals; D002417:Cattle; D015694:Gene Products, rev / Q000235:genetics*; D016370:Gene Products, rex / Q000235:genetics*; D005816:Genetic Complementation Test; D015497:HIV-1 / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000235:genetics; D009154:Mutation; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D054321:rev Gene Products, Human Immunodeficiency Virus
chemical_list: D015694:Gene Products, rev; D016370:Gene Products, rex; D012333:RNA, Messenger; D012367:RNA, Viral; D054321:rev Gene Products, Human Immunodeficiency Virus