title: Immunochemical studies for the presence of P-450 HFLa, a form of cytochrome P-450 in human fetal livers in human hepatocellular carcinoma cells.
abstract: Immunohistochemical localization of P-450 HFLa, a form of cytochrome P-450 in human fetal livers was investigated in human hepatocellular carcinoma. The cytoplasm of carcinoma cells positively reacted with anti-P-450 HFLa antibodies. It was found that the carcinoma cells showing a pseudoglandular pattern or poorly differentiated appearance exhibited a weaker reactivity with anti-P-450 HFLa antibodies than did relatively differentiated carcinoma cells. In the case of hepatoblastoma, the polygonal or round-shaped tumor cells which differentiated into epithelial structure exhibited a positive reaction with anti-P-450 HFLa antibodies, whereas the spindle-shaped tumor cells which showed a sarcomatous appearance did not react with the antibodies.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kitada
authors.forename: K
authors.initials: K
authors.lastname: Tsukidate
authors.forename: J
authors.initials: J
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Taneda
authors.forename: M
authors.initials: M
authors.lastname: Komori
authors.forename: H
authors.initials: H
authors.lastname: Ohi
authors.forename: K
authors.initials: K
authors.lastname: Itahashi
authors.forename: T
authors.initials: T
authors.lastname: Kamataki
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005333:Fetus / Q000201:enzymology; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000196:embryology / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology*
chemical_list: D003577:Cytochrome P-450 Enzyme System