Quinolone resistance in clinical isolates of Serratia marcescens.
The uptakes of norfloxacin by quinolone-resistant and -susceptible strains of Serratia marcescens were almost the same and 50% inhibitory concentrations for DNA gyrase and the MICs of quinolones were correlated, suggesting that DNA gyrase alterations are the basis of quinolone resistance.
Fujimaki
K
K
Episome Institute, Fujimi-mura, Seta-gun, Japan.
Fujii
T
T
Aoyama
H
H
Sato
K
K
Inoue
Y
Y
Inoue
M
M
Mitsuhashi
S
S
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000378:metabolism; D012706:Serratia marcescens / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014552:Urinary Tract Infections / Q000382:microbiology
D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D004250:DNA Topoisomerases, Type II; D009643:Norfloxacin