Characterization and in vivo distribution of 99mTc- and 111In-labelled magnetite.
Magnetite (Fe3O4) particles 0.1-0.5 microns in diameter doped with either 99mTc or 111In have been prepared and characterized by electron microscopy and Mössbauer spectroscopy. The time courses of their distributions after injection into rats were determined, including studies by gamma-camera imaging; the main targets were the liver and lung. The radiolabelled magnetic agents may be of value in research studies combining radio- and magnetic resonance imaging procedures.
Bligh
S W
SW
Department of Chemistry, Birkbeck College, University of London, England.
Sadler
P J
PJ
Marriott
J A
JA
Latham
I A
IA
Kelly
J D
JD
D000818:Animals; D052203:Ferrosoferric Oxide; D007205:Indium Radioisotopes; D007501:Iron / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010087:Oxides; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism; D013667:Technetium; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D010087:Oxides; D013667:Technetium; D007501:Iron; D052203:Ferrosoferric Oxide