Comparative effects of proligestone and megestrol acetate on basal plasma glucose concentrations and cortisol responses to exogenous adrenocorticotrophic hormone in cats.
Cats were given megestrol acetate (MA, 5 mg once daily for 14 days), subcutaneous proligestone (PRG, 100 mg on two occasions one week apart) or subcutaneous saline (1 ml as for PRG). In cats given saline (n = 6) basal cortical concentrations, cortisol concentrations after adrenocorticotrophic hormone (ACTH) administration and fasting blood glucose concentrations did not change significantly during the following seven weeks. Cats given MA (n = 7) developed suppression of basal and ACTH-stimulated cortisol concentrations and fasting hyperglycaemia during treatment. Effects on cortisol persisted for two weeks after MA dosage ceased. In cats given PRG (n = 7), basal cortisol concentrations were reduced overall, but only three cats had persistently suppressed post-ACTH cortisol concentrations. Adrenal suppression continued for 14 weeks in one of these and for at least 22 weeks in two cats. Fasting blood glucose concentrations were unchanged in PRG-treated cats.
Watson
A D
AD
Department of Veterinary Clinical Sciences, University of Sydney, New South Wales, Australia.
Church
D B
DB
Emslie
D R
DR
Middleton
D J
DJ
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002415:Cats / Q000097:blood* / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood*; D008535:Megestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D019290:Megestrol Acetate; D011374:Progesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology
D001786:Blood Glucose; D045167:Progesterone Congeners; D011374:Progesterone; C017677:proligestone; D000324:Adrenocorticotropic Hormone; D008535:Megestrol; D019290:Megestrol Acetate; D006854:Hydrocortisone