Inhibition of hepatic cholesterol synthesis by the alpha 1-adrenoceptor blocker doxazosin in the hypercholesterolemic golden hamster.
The effect of treatment with the alpha 1-specific adrenoceptor blocker, Doxazosin, on lipid parameters was studied in male Golden hamsters fed a cholesterol-enriched diet. Within 1 week the Doxazosin-treated animals had a lower plasma (-12%) and hepatic (-30%) cholesterol content than the cholesterol-fed controls. De novo cholesterol synthesis in the liver was lowered by 39% in the Doxazosin-treated animals. These data indicate that the reported beneficial effect of alpha 1-blockade on plasma cholesterol levels may be due to lowering of the hepatic cholesterol synthesis.
Jansen
H
H
Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam, The Netherlands.
Lammers
R
R
Baggen
M G
MG
Penders
J M
JM
Birkenhäger
J C
JC
D000085:Acetates / Q000378:metabolism; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D002791:Cholesterol, Dietary; D006224:Cricetinae; D017292:Doxazosin; D006937:Hypercholesterolemia / Q000378:metabolism*; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D011224:Prazosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D000085:Acetates; D000317:Adrenergic alpha-Antagonists; D002791:Cholesterol, Dietary; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D017292:Doxazosin; D011224:Prazosin