title: Neonatal antibody-dependent cellular cytotoxic antibody levels are associated with the clinical presentation of neonatal herpes simplex virus infection.
abstract: The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal anti-HSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 77% had localized and 23% had disseminated HSV infection. Antibody-dependent cellular cytotoxic (ADCC) antibodies were evaluated in comparison with HSV neutralizing antibodies. High maternal (greater than 1:10(4)) or neonatal (greater than 1:10(3)) anti-HSV ADCC antibody levels or high neonatal antiviral neutralizing levels (greater than 1:20) were independently associated with an absence of disseminated HSV infection. Cochran-Mantel-Haenszel analysis demonstrated that ADCC levels were associated with disease status (P less than .02) while controlling for the level of neutralizing antibody.
authors.affiliation: Department of Pediatrics University of Texas Medical School, Houston.
authors.forename: S
authors.initials: S
authors.lastname: Kohl
authors.forename: M S
authors.initials: MS
authors.lastname: West
authors.forename: C G
authors.initials: CG
authors.lastname: Prober
authors.forename: W M
authors.initials: WM
authors.lastname: Sullender
authors.forename: L S
authors.initials: LS
authors.lastname: Loo
authors.forename: A M
authors.initials: AM
authors.lastname: Arvin
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D004660:Encephalitis / Q000150:complications; D005260:Female; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D007232:Infant, Newborn, Diseases / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral