[The role of the brain monoaminergic systems in the effects of tuftsin and its analog on animal emotional behavior].
The effects of tuftsin and its analogue TP-1 (300 micrograms/kg) on the animal adaptive behaviour in emotionally different situations, the level of biogenic amines and their metabolites 10, 30 min., 2 and 6 hrs after injection of these substances were studies. The TP-1 induced an increase in the memory traces stability better than tuftsin in emotionally negative situation. A single injection of the peptides induced changes in NA, DA and their metabolites contents for 30 min. to 2 hrs. In contrast to tuftsin, the TP-1 activated the metabolism of 5-HT in the hypothalamus and caudal brainstem without changing the NA turnover. The data obtained suggests that a stronger psychotropic activity of the TP-1 seems to be caused by its obvious effect on biogenic amines and their metabolites level in the brain.
Semenova
G P
GP
Gurevich
E V
EV
Kozlovskaia
M M
MM
Gromova
E A
EA
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D004644:Emotions / Q000187:drug effects* / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology; D017983:Receptors, Catecholamine; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D011985:Receptors, Serotonin; D014405:Tuftsin
O roli monoaminergicheskikh sistem mozga v éffektakh taftsina i ego analoga na émotsional'noe povedenie zhivotnykh.