Hemodynamic effects of experimental iron poisoning.
The hemodynamic effects of severe iron poisoning were studied in five mongrel dogs. Anesthetized animals were instrumented with arterial, venous, and pulmonary artery thermodilution catheters. Iron intoxication was induced by orogastric administration of ferrous sulfate (600 mg/kg elemental iron). Pulmonary artery wedge pressure values were maintained near preintoxication values by saline infusion, and sodium bicarbonate (1.5 mEq/kg/dose) was given for pH less than 7.25. Hourly hemodynamic measurements were obtained for five hours. Cardiac output, mean arterial pressure, pH, and heart rate decreased significantly (P less than .05), whereas systemic vascular resistance, left ventricular stroke work, and oxygen consumption did not change. All animals developed metabolic acidosis despite saline (3.6 +/- 0.9 L, mean +/- SD) and bicarbonate administration (4.2 +/- 0.8 mEq/kg). These findings suggest that decreased cardiac output was partially due to decreased heart rate but not to decreased preload or abnormal left ventricular afterload. Alkali therapy and maintenance of oxygen consumption did not prevent development of metabolic acidosis.
Vernon
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Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84103.
Banner
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Dean
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D000138:Acidosis / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D002200:Capillary Resistance / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005440:Fluid Therapy; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood / Q000506:poisoning*; D010101:Oxygen Consumption / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate; D013318:Stroke Volume / Q000187:drug effects
D001639:Bicarbonates; D006454:Hemoglobins; D017693:Sodium Bicarbonate; D012964:Sodium; D007501:Iron