Effect of N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl- L-lysine on resistance to herpes simplex virus type-1 infection in cyclophosphamide-treated mice.
The restoration of resistance by N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine [MDP-Lys(L18)] on herpes simplex virus (HSV) type-1 infection was examined in cyclophosphamide (CY)-treated mice. MDP-Lys(L18) was shown to restore the resistance to HSV infection in CY-treated mice when it was injected either subcutaneously, intravenously, or intraperitoneally before infection. Treatment with MDP-Lys(L18) in CY-treated mice restored impaired activity for inhibiting HSV growth in the liver.
Ishihara
C
C
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Iida
J
J
Mizukoshi
N
N
Yamamoto
N
N
Yamamoto
K
K
Kato
K
K
Azuma
I
I
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002460:Cell Line; D003520:Cyclophosphamide / Q000494:pharmacology*; D004351:Drug Resistance; D004352:Drug Resistance, Microbial; D006561:Herpes Simplex / Q000188:drug therapy*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D003520:Cyclophosphamide; C036866:romurtide