Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus.
The effect of 6,4'-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0 degrees C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4'-dichloroflavan and 6,4'-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.
Superti
F
F
Istituto di Microbiologia, Facoltà di Medicina, Università di Roma La Sapienza, Italy.
Seganti
L
L
Orsi
N
N
Divizia
M
M
Gabrieli
R
R
Panà
A
A
Stein
M L
ML
D000998:Antiviral Agents; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D006507:Hepatovirus / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D005419:Flavonoids; C030933:4',6-dichloroflavan