title: The pathway of the quinol/quinone transhydrogenation reaction in ubiquinol: cytochrome-c reductase of Neurospora mitochondria.
abstract: Ubiquinol: cytochrome-c reductase, isolated from Neurospora mitochondria as a protein/Triton X-100 preparation, and reconstituted into phospholipid membranes, catalyses the electron transfer from duroquinol to 2.3-dimethoxy-5-decyl-6-methyl-benzoquinone (decQ) on a myxothiazol-insensitive, but antimycin-sensitive, ping-pong pathway. Duroquinol reacts first to form the altered, reduced enzyme E'. This reaction is followed by dissociation of duroquinone making way for E' to bind decQ and convert it into decQH2.
authors.affiliation: Institut für Biochemie, Universität Düsseldorf, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Zweck
authors.forename: G
authors.initials: G
authors.lastname: Bechmann
authors.forename: H
authors.initials: H
authors.lastname: Weiss
mesh_terms: D002384:Catalysis; D004579:Electron Transport; D014450:Electron Transport Complex III / Q000302:isolation & purification*; D006865:Hydrogenation; D006873:Hydroquinones / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism; D009491:Neurospora / Q000201:enzymology* / Q000378:metabolism; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism; D011809:Quinones / Q000378:metabolism*
chemical_list: D006873:Hydroquinones; D008563:Membrane Lipids; D010743:Phospholipids; D011809:Quinones; D014450:Electron Transport Complex III