Modulation of catecholamine effects during hypoglycaemia in man by urapidil and propranolol.
The hypothesis that in hypoglycaemia adrenoceptor-blocking drugs may enhance those metabolic effects of the catecholamines that remain unblocked has been investigated in 12 volunteers. alpha-Adrenoceptor blockade with urapidil increased the heart rate and the plasma noradrenaline level, and increased the beta-adrenoceptor mediated cellular uptake of potassium and phosphate, and the production of lactate. Posthypoglycaemic glucose intolerance and the counterregulatory responses of hGH and cortisol remained unchanged. Plasma adrenaline, the alpha-adrenoceptor mediated responses of cortisol and hGH, and the diastolic blood pressure were increased by propranolol. Adrenoceptor blocking drugs produce an indirect stimulatory effect by eliciting a reflex increase in sympathetic tone, which is manifested as stimulation of receptors of the type that has not been blocked.
Petersen
K G
KG
Department of Endocrinology, Albert-Ludwigs-Universität, Freiburg, Federal Republic of Germany.
Katschker
P
P
Kerp
L
L
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007003:Hypoglycemia / Q000097:blood*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011897:Random Allocation
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D001786:Blood Glucose; D002395:Catecholamines; D006063:Chorionic Gonadotropin; D007328:Insulin; D010879:Piperazines; C015568:urapidil; D011188:Potassium; D006854:Hydrocortisone