Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain.
Characteristic neuropathological white matter changes in the brains of patients dying from the acquired immune deficiency syndrome (AIDS) suggest pathogenetic involvement of either the PrP27-30 gene or a scrapie-related prion; however, proteinase-K resistant scrapie-like proteins could not be detected in brain tissue from AIDS patients.
Goldwater
P N
PN
Department of Microbiology, Adelaide Children's Hospital, South Australia.
Paton
J C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D015153:Blotting, Western; D001923:Brain Chemistry; D006801:Humans; D018622:PrP 27-30 Protein; D011328:Prions; D014764:Viral Proteins / Q000032:analysis
D011328:Prions; D014764:Viral Proteins; D018622:PrP 27-30 Protein