Investigative study of radiopharmaceuticals useful for imaging skeletal muscle injury in experimental animals.
An experimental animal model for studying skeletal muscle injury is described. Tc-99m PYP is accumulated on the skeletal muscle injury, but its uptake on the adjacent bone obscures its usefulness in delineating the extent of the muscle injury. In-111 antimyosin accumulates and delineates the extent of the skeletal muscle injury and does not accumulate on the adjacent bone. Hence, In-111 antimyosin is a good radiopharmaceutical for studying the severity and prognosis of skeletal muscle injury.
Owunwanne
A
A
Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat.
Malki
A
A
Sadek
S
S
el-Gazzar
A
A
Yacoub
T
T
Abdel-Dayem
H M
HM
D000818:Animals; D000911:Antibodies, Monoclonal; D011756:Diphosphates; D007205:Indium Radioisotopes; D009132:Muscles / Q000000981:diagnostic imaging / Q000293:injuries*; D009218:Myosins / Q000276:immunology*; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
D000911:Antibodies, Monoclonal; D011756:Diphosphates; D007205:Indium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D009218:Myosins