Tyramine conjugation test for prediction of treatment response in depressed patients.
In a group of 30 patients with major unipolar depressive disorder urinary excretion of tyramine sulphate was measured after an oral dose of tyramine. There was a significant correlation between impaired tyramine conjugation and response to tricyclic antidepressant medication.
Hale
A S
AS
Department of Psychiatry, United Medical School, St Thomas' Hospital, London.
Sandler
M
M
Hannah
P
P
Bridges
P K
PK
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000652:urine; D003866:Depressive Disorder / Q000188:drug therapy / Q000652:urine*; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D014439:Tyramine / Q000378:metabolism* / Q000652:urine
D000929:Antidepressive Agents, Tricyclic; D015415:Biomarkers; D014439:Tyramine