The hypotensive effect and antifungal activity of 3,3'-dihydroxy-alpha,beta-diethyldiphenylethane.
3,3'-Dihydroxy-alpha,beta-diethyldiphenylethane (I), an isomer of hexestrol (II), was found to have a strong hypotensive effect on rats and antifungal activity against some pathogenic fungi. The hypotensive effect of I (-100.0 +/- 21.0 mmHg, 10 mg/kg, i.v.) was stronger than that of II (-40.0 +/- 2.60 mmHg, i.v.). Unlike II and other oxystilbene-related compounds already tested, I showed prolonged hypotensive action at the dose of 10 mg/kg, and the blood pressure was not restored to the original level within 20 min. I also showed antifungal activity against all fungi tested (minimal inhibitory concentration: 10-120 micrograms/ml). It should be emphasized that by shifting the phenolic hydroxyl group to m-position, the biological activities were greatly increased.
Inamori
Y
Y
Ogawa
M
M
Ohno
Y
Y
Nishihata
S
S
Tsujibo
H
H
Miki
Y
Y
Takemura
S
S
D000818:Animals; D000935:Antifungal Agents; D001794:Blood Pressure / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006589:Hexestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology*
D000935:Antifungal Agents; D014665:Vasodilator Agents; D006589:Hexestrol; C056996:3,3'-dihydroxy-alpha,beta-diethyldiphenylethane