title: Atopic dermatitis and the indoor climate. The effect from preventive measures.
abstract: Nine patients with atopic dermatitis (AD) were clinically evaluated before and after moving to new houses with improved air exchange, low relative humidity and optimal temperature control. During a 2-year period three clinical and subjective assessments were performed each month of disease activity, and compared with changes in suspended and respirable dust particles, room temperature, air exchange rate, concentration of house-dust mites in bedrooms, and the concentration of organic solvents in the indoor air. Ten matched patients with AD, who did not move, served as a control group. The skin condition of patients moved improved significantly after moving. The indoor climate was improved on: 1) air exchange rate, 2) relative humidity, and 3) room temperature, but the amounts of house dust mites, respirable air particles and organic solvents were unchanged. The clinical and subjective improvement in AD could not be correlated to any single indoor environmental factor. The present investigation supports the current concept, that AD may be a multifactorial disease, and that the indoor climate may be a contributing factor affecting the eczema.
authors.affiliation: Department of Dermatology and Venereology, Marselisborg Hospital Arhus, Denmark.
authors.forename: H I
authors.initials: HI
authors.lastname: Beck
authors.forename: P
authors.initials: P
authors.lastname: Bjerring
authors.forename: H
authors.initials: H
authors.lastname: Harving
mesh_terms: D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects; D000485:Allergens; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006813:Humidity; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D012111:Residence Characteristics; D013696:Temperature; D014691:Ventilation
chemical_list: D000393:Air Pollutants; D000485:Allergens