title: Small cell carcinoma of the vagina with neuroendocrine features. A report of three cases.
abstract: Three patients were treated for primary small cell carcinoma of the vagina. The light microscopic features were similar to those of small cell carcinoma of the lung, cervix and endometrium. Electron microscopy revealed occasional cytoplasmic, neurosecretory-type granules and cytoplasmic processes, features consistent with neuroendocrine cells. Radiotherapy appears to provide local control, but widespread disease at presentation or early metastases suggest the use of adjuvant chemotherapy in the initial management of the neoplasm.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor.
authors.forename: M P
authors.initials: MP
authors.lastname: Hopkins
authors.forename: N B
authors.initials: NB
authors.lastname: Kumar
authors.forename: A S
authors.initials: AS
authors.lastname: Lichter
authors.forename: W A
authors.initials: WA
authors.lastname: Peters
authors.forename: G W
authors.initials: GW
authors.lastname: Morley
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000532:radiotherapy; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008854:Microscopy, Electron; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000532:radiotherapy