Mutagenicity in V79 Chinese hamster cells of n-alkanals produced by lipid peroxidation.
The mutagenicity for mammalian cells of five n-alkanals produced by lipid peroxidation was tested in V79 Chinese hamster lung cells either at the hypoxanthine-guanine phosphoribosyltransferase locus as resistance to 6-thioguanine or at the Na/K ATPase locus as resistance to ouabain. The results show that propanal, butanal, pentanal and hexanal induced a dose-dependent increase in the frequency over controls of both 6-thioguanine- and ouabain-resistant mutants at concentrations ranging from 3 to 30 mM. With nonanal the same effects were observed with concentrations of 0.1-0.3 mM.
Brambilla
G
G
Institute of Pharmacology, University of Genoa, Italy.
Cajelli
E
E
Canonero
R
R
Martelli
A
A
Marinari
U M
UM
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung; D008698:Mesylates; D008770:Methylnitrosourea; D009153:Mutagens; D009154:Mutation
D000447:Aldehydes; D008698:Mesylates; D009153:Mutagens; C045880:methanesulfonic acid; D008770:Methylnitrosourea