Human papilloma virus infection and skin cancer in renal allograft recipients.
202 renal allograft recipients in south-east Scotland, who had received transplants between 1965 and 1986, were monitored over 3 years (1984-87) for the presence of warts, keratoses, and skin cancers. 77% of 69 patients with graft survival of more than 5 years had viral warts, 38% had keratoses, and 12% had skin cancers, whereas of the 133 with graft survival of less than 5 years 20% had warts, 17% had keratoses, and 1.5% had skin cancers. The ratio of squamous cell carcinoma to basal cell carcinoma was 15:1. Most viral warts showed significant epidermal dysplasia, and keratoses and squamous cell carcinomas had signs of human papilloma virus infection. 15 (60%) of 25 squamous cell carcinomas contained HPV5/8 DNA and 1 contained HPV4 DNA--HPV5/8 DNA was detected in skin lesions of recipients with cancers significantly more often than in those matched for duration and type of immunosuppression with nonmalignant skin lesions. The findings suggest a role for HPV5/8 in the aetiology of squamous cell carcinoma in renal allograft recipients.
Barr
B B
BB
University Department of Bacteriology, Royal Infirmary, Edinburgh, Scotland.
Benton
E C
EC
McLaren
K
K
Bunney
M H
MH
Smith
I W
IW
Blessing
K
K
Hunter
J A
JA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000032:analysis / Q000209:etiology* / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000032:analysis / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000209:etiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006085:Graft Survival; D006801:Humans; D006824:Hybridization, Genetic; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000032:analysis / Q000209:etiology / Q000473:pathology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000032:analysis / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects; D013997:Time Factors; D014412:Tumor Virus Infections / Q000032:analysis / Q000150:complications* / Q000473:pathology
D004279:DNA, Viral