Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs.
Treatment of healthy dogs with the butyrophenone derivative, lenperone hydrochloride, at two different doses significantly decreased gastroesophageal sphincter pressure (GESP). No dose-related effect was identified. Individual variation in the response to lenperone hydrochloride was noted which was consistent on a day-to-day basis. Lenperone hydrochloride is unsuitable for chemical restraint of dogs undergoing esophageal manometry because it decreases GESP and because the magnitude of the decrease varies considerably between dogs.
Johnson
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Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Zelner
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A
Sherding
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RG
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002090:Butyrophenones / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011312:Pressure
D014150:Antipsychotic Agents; D002090:Butyrophenones; C100204:lenperone