title: Analogy between tumor uptake of technetium(V)-99m dimercaptosuccinic acid (DMSA) and technetium-99m-MDP.
abstract: Sixty patients with a variety of malignant tumors were examined with Tc-99m(V) dimercaptosuccinic acid (DMSA) prepared by modification of a commercially available DMSA kit. Significant uptake of Tc-99m(V)-DMSA was observed in a number of tumors, offering additional clinically useful information. In the majority of cases in this study, however, the benefit of the Tc-99m(V)-DMSA image was limited because of low sensitivity. The most striking observation was the similarity between the tumor concentration of Tc-99m(V)-DMSA and the Tc-99m-MDP uptake in the tumor on the regular bone image. Therefore, patients with Tc-99m-MDP uptake in nonosseous tumor sites on the bone scan may be suitable candidates for tumor imaging with Tc-99m(V)-DMSA.
authors.affiliation: Department of Radiotherapy and Nuclear Medicine, University Hospital Ghent, Belgium.
authors.forename: D A
authors.initials: DA
authors.lastname: Wulfrank
authors.forename: K H
authors.initials: KH
authors.lastname: Schelstraete
authors.forename: F
authors.initials: F
authors.lastname: Small
authors.forename: C J
authors.initials: CJ
authors.lastname: Fallais
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging; D005069:Evaluation Studies as Topic; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D004113:Succimer / Q000138:chemical synthesis / Q000493:pharmacokinetics; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013669:Technetium Tc 99m Medronate
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer; D013669:Technetium Tc 99m Medronate