Expression of the bovine leukemia virus transactivator protein p34 by a recombinant vaccinia virus.
In order to characterize the bovine leukemia virus transactivator protein, a recombinant vaccinia virus (v-LOR) containing the BLV post-envelope long open reading frame was constructed. v-LOR was shown to encode a functional protein able to transactivate the BLV long terminal repeat-directed gene expression in the infected cells. The encountered level of transactivation was about one third of that measured in BLV-infected fetal lamb kidney cell lysates.
Willems
L
L
Faculty of Agronomy, Gembloux, Belgium.
Letellier
C
C
Gonze
M
M
Martin
R
R
Kettmann
R
R
Burny
A
A
Meulemans
G
G
D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D005822:Genetic Vectors; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics*; D014616:Vaccinia virus / Q000235:genetics
D004279:DNA, Viral; D011994:Recombinant Proteins; D015682:Retroviridae Proteins, Oncogenic; D015534:Trans-Activators