title: Transplantable Marek's disease lymphomas. III. Induction of MHC-restricted tumor immunity by lymphoblastoid cells in F1 hosts.
abstract: F1 chickens, which were a cross between birds of the related inbred lines G-B1 and G-B2, were immunized with in vitro cultured virus-non-producer lymphoblastoid cells that were either syngeneic or allogeneic with the challenge tumor cells. The lymphoblastoid cells were derived from Marek's disease herpesvirus (MDV)-induced transplantable tumors. Previous findings showed that such immunization of G-B1 and G-B2 chickens prevented early mortality caused by the tumors. Lymphoblastoid cells syngeneic with the tumors were more effective than allogeneic cells, suggesting that an MHC-restricted immune response was induced, or, alternatively, that immune elimination of allogeneic cells prevented them from initiating strong immunity to MDV-associated tumor antigens. Immune elimination of the immunizing cells should not occur in F1 birds heterozygous for the 2 different parental MHC haplotypes (B6 and B13). Early mortality among F1 chickens immunized with lymphoblastoid cells that were syngeneic with the challenge tumor cells was significantly lower than for non-immunized control chickens or for birds immunized with lymphoblastoid cells that were allogeneic with the challenge tumor cells. Our results suggest that MDV-induced tumor antigens may be recognized by the host as altered-self MHC antigens.
authors.affiliation: Department of Medical Microbiology, University of Georgia, Athens 30605.
authors.forename: N L
authors.initials: NL
authors.lastname: DiFronzo
authors.forename: L W
authors.initials: LW
authors.lastname: Schierman
mesh_terms: D000818:Animals; D002645:Chickens; D008381:Herpesvirus 2, Gallid / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D007114:Immunization; D008380:Marek Disease / Q000276:immunology*; D009368:Neoplasm Transplantation
chemical_list: D006649:Histocompatibility Antigens