title: Norwalk virus in Norway: an outbreak of gastroenteritis studied by electron microscopy and radioimmunoassay.
abstract: An outbreak of acute gastroenteritis affected approximately half of 40 children staying at a holiday centre in Southern Norway. By direct electron microscopy Norwalk-like viruses were demonstrated in 4/8 available stool specimens. No other pathogens were detected. Antibody against these viruses was demonstrated by immune electron microscopy in all of 7 convalescent phase sera but in none of 11 acute phase sera collected. Radioimmunoassay examination showed a rise in titre of Norwalk virus antibody in 6 available paired sera. This outbreak of Norwalk virus gastroenteritis in Norway was thus documented by a combined use of direct and immune electron microscopy and radioimmunoassay.
authors.affiliation: Department of Virology, National Institute of Public Health, Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Kjeldsberg
authors.forename: G
authors.initials: G
authors.lastname: Anestad
authors.forename: H
authors.initials: H
authors.lastname: Greenberg
authors.forename: I
authors.initials: I
authors.lastname: Orstavik
authors.forename: R
authors.initials: R
authors.lastname: Pedersen
authors.forename: E
authors.initials: E
authors.lastname: Slettebø
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008854:Microscopy, Electron; D009663:Norwalk virus / Q000276:immunology* / Q000302:isolation & purification / Q000648:ultrastructure; D009664:Norway / Q000453:epidemiology; D011863:Radioimmunoassay; D014777:Virus Diseases / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology
chemical_list: D000914:Antibodies, Viral