title: [Pilot combination phase II study of mitomycin C plus cisplatin for non-small cell lung cancer].
abstract: Fifteen patients (six patients with adenocarcinoma, seven patients with squamous cell carcinoma, and two patients with large cell carcinoma) with advanced non-small cell lung cancer (NSCLC) were evaluable for mitomycin C (MMC; 8 mg/m2 day 1, 8, every 3-4 weeks) plus cisplatin (CDDP; 80 mg/m2 day 1, every 3-4 weeks). Ten patients had had prior chemotherapy. Among 15 evaluable patients, no patient achieved complete response, and two patients showed partial response. The response rate of MMC plus CDDP against NSCLC was 13.3%. Toxic effects included anorexia (80%), nausea and vomiting (67%), leukopenia (53%), anemia (47%), nephrotoxicity (47%), thrombopenia (27%), liver injury (27%), and fever (7%). These toxic effects were reversible and manageable. The combination of MMC and CDDP appears to be valuable regimen against advanced NSCLC.
authors.affiliation: 3rd Dept. of Internal Medicine, Tokushima University School of Medicine.
authors.forename: E
authors.initials: E
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: J
authors.initials: J
authors.lastname: Mukai
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: E
authors.initials: E
authors.lastname: Kunishige
authors.forename: K
authors.initials: K
authors.lastname: Fukuta
authors.forename: K
authors.initials: K
authors.lastname: Tani
authors.forename: S
authors.initials: S
authors.lastname: Sone
authors.forename: T
authors.initials: T
authors.lastname: Ogura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000855:Anorexia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007564:Japan; D007970:Leukopenia / Q000139:chemically induced; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects; D009325:Nausea / Q000139:chemically induced; D010865:Pilot Projects; D012074:Remission Induction; D014839:Vomiting / Q000139:chemically induced
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D002945:Cisplatin