Resistance of Escherichia coli to nourseothricin (streptothricin): reduced penetrability of the cell wall as an additional, possibly unspecific mechanism.
The resistance of E. coli strains to the antibiotic nourseothricin is known to be caused by an acetyltransferase acetylating the beta-lysine chain of the antibiotic. In addition, most of the resistant strains exhibit reduced penetrability of the outer membrane, presumably caused by a reduced amount of available negative charges. This was shown using crystal violet, Congo red, or the hydrophobic antibiotic novobiocin as indicators.
Seltmann
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Institute of Experimental Epidemiology, Wernigerode, DDR.
D000042:Absorption; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000378:metabolism; D004396:Coloring Agents / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005840:Gentian Violet / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology; D011190:Potassium Cyanide / Q000494:pharmacology; D013309:Streptothricins / Q000378:metabolism / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004396:Coloring Agents; D009675:Novobiocin; D013309:Streptothricins; D005840:Gentian Violet; D011190:Potassium Cyanide