Immunohistochemical study of monoclonal antibody MGD-1 in gastric carcinoma.
This paper reports a pathological and immunohistochemical study of gastric carcinoma for immunoreactivity with a monoclonal antibody. MGD-1, raised against cells from an adenocarcinoma of stomach. Fifty-four of 61 gastric carcinomas (89%) were positive for MGD-1. Metastatic gastric carcinoma in local nodes was positive in all 11 such cases. Out of 40 examples of chronic atrophic gastritis, only three, with mild dysplasia, were positive (7.5%). Forty cases with normal gastric mucosa were negative. The MGD-1 detection-rate of well- and poorly-differentiated gastric carcinoma was 85% and 93% respectively. The metastatic cells and cells infiltrating the submucosa and muscular layer were more frequently positive and showed stronger staining with MGD-1 than those in mucosa. These results show that MGD-1 possesses a high degree of specificity for gastric carcinoma and could be used diagnostically.
Chao
C Y
CY
Department of Pathology, 4th Military Medical College, Xian, People's Republic of China.
Lie
J
J
Fan
D M
DM
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000276:immunology / Q000473:pathology; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm