Interrelationship between cyclic AMP level and chondrogenesis in vitro.
A consistent chondrogenesis takes place in micro-mass cultures of stage 23-24 chicken limb bud mesenchymal cells. In these cultures a short, marked elevation of cAMP level was detected at the time of the onset of cartilage phenotype expression. On the other hand, exogeneous glycosaminoglycans which inhibited chondrogenesis caused a reduction in the cAMP level of the cells. These correlations between cAMP level and phenotypic characteristics suggest that, among other things required in chondrogenesis, cAMP level may be a prominent factor.
Hadházy
C
C
László
M B
MB
D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D002478:Cells, Cultured; D002642:Chick Embryo; D000242:Cyclic AMP / Q000502:physiology*; D005121:Extremities / Q000196:embryology; D006025:Glycosaminoglycans / Q000494:pharmacology; D008648:Mesoderm / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009024:Morphogenesis
D006025:Glycosaminoglycans; D000242:Cyclic AMP