Noradrenergic control of ascorbic acid and glutathione concentrations in brown fat of cold-exposed rats.
Ascorbic acid and glutathione concentrations increase in brown fat of cold-exposed rats. This phenomenon can be reproduced by noradrenaline or isoproterenol administration, and thus seems to be under sympathetic control. Histological study shows ascorbic acid storage in brown adipocyte nuclei.
Mory
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Laboratoire de Physiologie Comparée (CNRS URA 307), Université Pierre et Marie Curie, Paris, France.
Bal
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Combes-George
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D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D003080:Cold Temperature; D005978:Glutathione / Q000378:metabolism*; D006651:Histocytochemistry; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D010656:Phenylephrine; D005978:Glutathione; D007545:Isoproterenol; D001205:Ascorbic Acid; D009638:Norepinephrine