title: Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400.
abstract: Cloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
authors.affiliation: Division of Behavior and Neurobiology, National Institute for Basic Biology, Okazaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Furuichi
authors.forename: S
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: A
authors.initials: A
authors.lastname: Miyawaki
authors.forename: K
authors.initials: K
authors.lastname: Wada
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Mikoshiba
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D015220:Calcium Channels; D002531:Cerebellum / Q000378:metabolism; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D015723:Gene Library; D005796:Genes; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear; D015183:Restriction Mapping; D012433:Ryanodine / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000911:Antibodies, Monoclonal; D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D018160:Receptors, Cytoplasmic and Nuclear; D019837:Ryanodine Receptor Calcium Release Channel; D012433:Ryanodine; D015544:Inositol 1,4,5-Trisphosphate; D004247:DNA