MPTP-induced ventral mesencephalic cell loss in the cat.
Immunohistochemical analysis of tyrosine hydroxylase (TH)-containing neurons in the cat ventral mesencephalon revealed a marked loss of substantia nigra pars compacta neurons and moderate losses of TH-positive neurons in the ventral tegmental area, retrorubral or A8 region, and in the substantia nigra pars lateralis of cats treated with the neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The pattern and magnitude of cell loss in these ventral mesencephalic regions parallels that previously reported for the MPTP-treated monkey. These results further support the use of the cat as a model for studying the pathology to catecholaminergic neurons induced by MPTP.
Williams
J L
JL
Department of Neurology, Hahnemann University School of Medicine, Philadelphia, PA 19102.
Schneider
J S
JS
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002415:Cats; D002452:Cell Count; D004298:Dopamine / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D011725:Pyridines / Q000633:toxicity*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine