Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.
A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.
Litt
M
M
Department of Biochemistry, Oregon Health Sciences University, Portland 97201.
Luty
J
J
Kwak
M
M
Allen
L
L
Magenis
R E
RE
Mandel
G
G
D000818:Animals; D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000648:ultrastructure*; D006224:Cricetinae; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D015222:Sodium Channels
D015342:DNA Probes; D015222:Sodium Channels