Metal complexes of antiinflammatory drugs. Part VII: Salsalate complex of copper(II).
The preparation and properties of the Cu(II) complex Cu(SAS)2.H2O are reported for the antiinflammatory drug Salsalate (SAS). The diffuse reflectance spectra and magnetic moments are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The Cu(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
Underhill
A E
AE
Department of Chemistry, University College of North Wales, Bangor, United Kingdom.
Bury
A
A
Odling
R J
RJ
Fleet
M B
MB
Stevens
A
A
Gomm
P S
PS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000032:analysis*; D008280:Magnetics; D012459:Salicylates / Q000032:analysis*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D013481:Superoxides; D003300:Copper; D013482:Superoxide Dismutase; C014182:salicylsalicylic acid