[Cyclic AMP and cyclic GMP level in cells of spontaneously aborted fetuses with trisomic and triploid karyotypes].
Contents of intracellular cAMP and cGMP were studied in cultivated fibroblasts from 4 spontaneous abortuses with trisomy 7 and trisomy 9 as well as in 4 triploid cell strains. Six diploid cell strains from medical abortuses were used as controls. Distinct increase in cAMP content both calculated per I mg of cell protein or per a cell was found in trisomic strains, whereas the cAMP content increase in triploid strains was detected only per a cell. The data obtained suggest that functions of membrane complexes were impaired in the cells with anomalous karyotype.
Kukharenko
V I
VI
Khokhlova
Iu V
IuV
D000022:Abortion, Spontaneous; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000032:analysis*; D005260:Female; D005333:Fetus / Q000032:analysis* / Q000166:cytology; D005347:Fibroblasts / Q000032:analysis; D006801:Humans; D011003:Ploidies; D011247:Pregnancy; D014314:Trisomy
D000242:Cyclic AMP; D006152:Cyclic GMP
Uroven' tsAMF i tsGMF v kletkakh spontannykh abortusov s trisomnym i triploidnym kariotipom.