title: An association between mineral metabolism and the renin-aldosterone system in human hypertension.
abstract: In recent years abnormalities of calcium metabolism have been described in human hypertension. In this study, the relationships between indices of calcium metabolism and the renin-aldosterone system were studied in 39 subjects with untreated essential hypertension. No significant associations were found between the major determinants of calcium metabolism (plasma ionised calcium, parathyroid hormone and 1,25(OH)2-vitamin D) and the renin-aldosterone system. Serum magnesium was, however, positively correlated to plasma renin activity (PRA) (r = 0.38, P less than 0.05) while both 24 h urinary excretion of calcium and cAMP were found to be correlated to both PRA and urinary aldosterone in a positive way (r = 0.39-0.42, P less than 0.01 and r = 0.33-0.57, P less than 0.01, respectively). In this study there was no other evidence of any major influence of the renin-aldosterone status on the calcium balance in human hypertension. The urinary leak of calcium might be determined by the action of the renin-aldosterone system.
authors.affiliation: Department of Internal Medicine, Uppsala University, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Lind
authors.forename: L
authors.initials: L
authors.lastname: Wide
authors.forename: O H
authors.initials: OH
authors.lastname: Sörensen
authors.forename: S
authors.initials: S
authors.lastname: Ljunghall
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000652:urine
chemical_list: D008903:Minerals; D000450:Aldosterone; D012964:Sodium; D000242:Cyclic AMP; D012083:Renin; D008274:Magnesium; D002118:Calcium