Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical alpha 1-adrenoceptors.
Chronic administration of mianserin induced an increase in the density of [3H] prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat brain cortical alpha 1-adrenoceptors may depend on the characteristics of the drug used.
Sallés
J
J
Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Spain.
Claro
E
E
García
A
A
Picatoste
F
F
Badia
A
A
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D011530:Protriptyline / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013997:Time Factors
D003986:Dibenzocycloheptenes; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D008803:Mianserin; D011530:Protriptyline; D009638:Norepinephrine; D011224:Prazosin