Glucoregulatory function of thyroid hormones: evidence for an insulin-independent effect.
The effect of hyperglycemia on glucose kinetics was investigated in normal and T4-treated miniature pigs. 1. T4-treatment increased basal plasma glucose (G) (+ 20%) and glucose turnover (+36%). 2. Glucose infusion (2 mg/kg x min) in controls increased insulin and glucose utilization (Rd), but decreased glucagon and hepatic glucose production (Ra). After T4-treatment glucose increased insulin, decreased glucagon and Ra but only a slight effect on G and Rd were observed. 3. Infusing glucose + somatostatin resulted in hyperglycemia in both groups due to an initial fall in Ra and Rd followed by an increase in Rd, where total Ra (endogenous + exogenous exceeded Rd. Glucose intolerance was more pronounced in controls, due to a T4-induced increase in Rd. During this non-steady state the increment in Rd per increment in G was calculated and showed 1.5 in controls and 2.5 after T4-treatment. These data give evidence that thyroid hormones increase glucose utilization during hypoinsulinemia.
Müller
M J
MJ
Medizinische Hochschule Hannover, Abt. Klin, Endokrinologie, FRG.
Möring
J
J
Paschen
U
U
Seitz
H J
HJ
D000818:Animals; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology; D006980:Hyperthyroidism / Q000378:metabolism / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D013004:Somatostatin / Q000494:pharmacology; D013552:Swine; D013963:Thyroid Hormones / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology
D007328:Insulin; D013963:Thyroid Hormones; D013004:Somatostatin; D005947:Glucose; D013974:Thyroxine