title: Beginnings and main directions of psychoneuroimmunology.
abstract: The present paper offers a survey of advances in the domain of psychoneuroimmunology. Major topics covered are the role of the nervous system in regulation of the immune system functions, neuromediator and neuroendocrine mechanisms for regulation of the lymphoid cell activity and hypothalamic involvement in modulation of the activity of bone marrow as a source of stem cells. Emphasis has been on the neurophysiological correlates of the organism's reaction to antigen. Attention has been given to the work of A.D. Speransky and discussion of the psychoneuroimmunologic research based on literature data and findings from our own studies is presented in the historical context.
authors.affiliation: Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Leningrad, U.S.S.R.
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
mesh_terms: D000818:Animals; D000917:Antibody Formation; D006728:Hormones / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007111:Immunity, Cellular; D018377:Neurotransmitter Agents / Q000502:physiology; D011598:Psychoneuroimmunology / Q000639:trends*
chemical_list: D006728:Hormones; D018377:Neurotransmitter Agents