title: [The pharmacology of 1-(2-pyrimidinyl)piperazine, a metabolite of buspirone].
abstract: In experiments on rats the anxiolytic activity of 1-(2-pyrimidinyl)-piperazine (PP) was revealed only in some models of anxiety states, although diazepam was effective in all used models. In contrast to diazepam, PP exerts the anesthetic-potentiating and myorelaxant effects only when administered in subtoxic doses and possesses no anticorazole activity. The facts testifying to the serotoninergic mechanisms of the anxiolytic action of 1-(2-pyrimidinyl)-piperazine are presented.
authors.forename: I V
authors.initials: IV
authors.lastname: Komissarov
authors.forename: V I
authors.initials: VI
authors.lastname: Dulenko
authors.forename: N A
authors.initials: NA
authors.lastname: Kharin
authors.forename: S V
authors.initials: SV
authors.lastname: Tolkunov
authors.forename: A N
authors.initials: AN
authors.lastname: Talalaenko
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D002065:Buspirone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D051379:Mice; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; C037921:1-(2-pyrimidinyl)piperazine; D003975:Diazepam; D002065:Buspirone
vernacular_title: Farmakologiia 1-(2-pirimidinil)-piperazina, metabolita buspirona.