Effect of selected antiarrhythmic drugs on the superoxide anion production by polymorphonuclear neutrophils in vitro.
The oxygen radicals produced by polymorphonuclear neutrophils (PMN) during ischemia and reperfusion play an important role in the development of arrhythmias. We investigated the influence of selected antiarrhythmic drugs on PMN superoxide anion production. Amiodarone, verapamil and propranolol significantly decreased the stimulated superoxide anion production, which may be an additional mechanism of their antiarrhythmic activity. The fast sodium channel inhibitors lidocaine, procainamide and mexiletine affected neither spontaneous nor stimulated superoxide anion production.
Wysocka
E
E
Academy of Medicine, Department of Intensive Therapy, Poznan, Poland.
Wysocki
H
H
Siminiak
T
T
Szczepanik
A
A
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D013481:Superoxides