title: Differential distribution of GABAA receptor mRNAs in bovine cerebellum--localization of alpha 2 mRNA in Bergmann glia layer.
abstract: Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the alpha 2 mRNA appears to be confined to the Bergmann glial cell layer. The alpha 3 mRNA is only expressed in the Golgi cells. This differential distribution of GABAA receptor mRNA subtypes suggests a previously unrecognized complexity of GABAergic transmission in the cerebellum.
authors.affiliation: MRC Molecular Neurobiology Unit, MRC Centre, Cambridge U.K.
authors.forename: W
authors.initials: W
authors.lastname: Wisden
authors.forename: L A
authors.initials: LA
authors.lastname: McNaughton
authors.forename: M G
authors.initials: MG
authors.lastname: Darlison
authors.forename: S P
authors.initials: SP
authors.lastname: Hunt
authors.forename: E A
authors.initials: EA
authors.lastname: Barnard
mesh_terms: D000818:Animals; D002417:Cattle; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011963:Receptors, GABA-A