Chronotropic responses in rats implanted with an acrylic orthopaedic cement.
The chronotropic and inotropic responses were studied in isolated atria and papillary muscles from rats who had carried a pellet of methyl methacrylate polymer for one week and from sham operated control rats. Right atria isolated from implanted rats were hyporesponsive to the positive chronotropic effects of isoproterenol and glucagon but not to dibutyryl cAMP or to CaC12. Inotropic response of left atria and papillary muscles to isoproterenol was unaltered. No change in the beta-receptor density or affinity was associated with these phenomena. The results indicate that methyl methacrylate exposure leads to a disruption in the signal transduction of chronotropic stimuli mediated by the adenylate cyclase system. The alteration occurs at some point after receptor binding and before cAMP action.
Camilion de Hurtado
M C
MC
Center of Cardiovascular Research, Faculty of Medical Sciences, La Plata, Argentina.
Gende
O A
OA
D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D001843:Bone Cements / Q000633:toxicity*; D003994:Bucladesine / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D004082:Dihydroalprenolol; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D010210:Papillary Muscles / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000179:Acrylates; D001843:Bone Cements; D004082:Dihydroalprenolol; D003994:Bucladesine; D005934:Glucagon; D007545:Isoproterenol; D002122:Calcium Chloride