Proliferative T-cell response to HIV envelope glycoprotein in immunized and infected primates and human beings.
Human immunodeficiency virus (HIV)-specific helper T-cell response was studied in human subjects and nonhuman primates either infected with HIV or immunized with different HIV protein preparations. A strong group-specific T-cell response involving T-cell proliferation and lymphokine secretion was observed in immunized chimpanzees and rhesus monkeys as well as HIV-infected chimpanzees and gibbons. HIV-infected people demonstrated a low or no HIV-specific T-cell response. In contrast, five of 14 HIV antibody-negative sexual partners of HIV-infected men recognized one or more T-cell epitopes in the envelope glycoprotein of HIV.
Krohn
K
K
Institute of Biomedical Sciences, University of Tampere, Finland.
Ranki
A
A
Lusso
P
P
Moss
B
B
Ashorn
P
P
Arthur
L O
LO
Putney
S D
SD
Gallo
R C
RC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D015699:HIV Envelope Protein gp120; D015497:HIV-1 / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D006922:Hylobates; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008297:Male; D002679:Pan troglodytes; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D012191:Retroviridae Proteins / Q000276:immunology*; D012747:Sexual Partners; D013601:T-Lymphocytes / Q000276:immunology*
D015699:HIV Envelope Protein gp120; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins