[Signal transmission using second messengers].
Intercellular communication needs signal molecules (hormones, neurotransmitters, growth factors) emitted by a cell and recognized by targets. A widespread mechanism of cellular action of these molecules involves a membrane receptor, a GTP-dependent coupling protein, an effector which modulates the intracellular concentration of a second messenger (cAMP, cGMP, inositol triphosphate, Ca++), and a target for final effect of this second messenger (kinases, channel). Hormonal systems and visual processes in vertebrates rod outer segments are the best known examples of this mechanism; they are taken here to illustrate the state of knowledge of the interactions between the actors of the transductional enzymatic cascades.
Pfister
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Centre d'études nucléaires de Grenoble, biophysique moléculaire et cellulaire, France.
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000502:physiology; D000262:Adenylyl Cyclases / Q000502:physiology; D002450:Cell Communication; D006160:Guanosine Triphosphate / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D010786:Photoreceptor Cells / Q000201:enzymology / Q000378:metabolism*; D012243:Rhodopsin / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D015293:Transducin / Q000502:physiology
C029152:G-substrate; D009419:Nerve Tissue Proteins; D006160:Guanosine Triphosphate; D012243:Rhodopsin; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D015293:Transducin; D000262:Adenylyl Cyclases
La transmission de signal utilisant les seconds messagers.