Shift from a mixed to a lactovegetarian diet: influence on acidic lipids in fecal water--a potential risk factor for colon cancer.
Although there have recently been reports in the literature indicating that vegetarian-type diets are protective against the development of human colon cancer, this is still far from clear. It was also recently indicated that the concentration of acidic lipids in the aqueous phase of stool constitutes a risk factor for the development of colon cancer. Thus, we examined the effect of a change from a mixed to a lactovegetarian diet on this fecal variable. The dietary change caused a decrease in the total concentration of soluble fecal fatty acids (4310 +/- 3020 to 1080 +/- 1040 mumol/L, p less than 0.05) and deoxycholic acid (125 +/- 42 to 73 +/- 35 mumol/L, p less than 0.05). However, there was no change in either the total bile acid concentration in (164 +/- 54 to 107 +/- 41 mumol/L) or the cellular toxicity of (0.94 +/- 0.55 to 1.60 +/- 0.63 mumol/L, relative survival) the aqueous phase of stool. Thus, the consumption of a lactovegetarian diet may reduce certain risk factors of potential significance in colon carcinogenesis.
Allinger
U G
UG
Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden.
Johansson
G K
GK
Gustafsson
J A
JA
Rafter
J J
JJ
D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis; D001834:Body Water / Q000032:analysis; D002462:Cell Membrane / Q000187:drug effects; D003110:Colonic Neoplasms / Q000209:etiology* / Q000378:metabolism; D014676:Diet, Vegetarian; D004043:Dietary Fiber; D002149:Energy Intake; D005243:Feces / Q000032:analysis; D005260:Female; D005638:Fruit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000187:drug effects; D008055:Lipids / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014675:Vegetables
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D008055:Lipids