title: Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders.
abstract: Chlordesmethyldiazepam a long-acting benzodiazepine was compared with lorazepam a short-acting one in a double-blind placebo cross-over study against generalized anxiety disorders. Chlordesmethyldiazepam therapy was more effective than lorazepam. Clinical efficacy, drowsiness and insomnia seem well correlated with pharmacokinetic properties of these two benzodiazepines. These results further support the use of a long-acting benzodiazepine rather than a short-acting one as an anti-anxiety agent.
authors.affiliation: Institute of Psychiatry, University of Padua, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Bertin
authors.forename: G
authors.initials: G
authors.lastname: Colombo
authors.forename: M
authors.initials: M
authors.lastname: Furlanut
authors.forename: P
authors.initials: P
authors.lastname: Benetello
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000097:blood / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D001569:Benzodiazepines; D003975:Diazepam / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; D008140:Lorazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam