title: The murine Il-6 gene maps to the proximal region of chromosome 5.
abstract: Murine Il-6 cDNAs were isolated by cross-hybridization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.
authors.affiliation: Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892.
authors.forename: B A
authors.initials: BA
authors.lastname: Mock
authors.forename: R P
authors.initials: RP
authors.lastname: Nordan
authors.forename: M J
authors.initials: MJ
authors.lastname: Justice
authors.forename: C
authors.initials: C
authors.lastname: Kozak
authors.forename: N A
authors.initials: NA
authors.lastname: Jenkins
authors.forename: N G
authors.initials: NG
authors.lastname: Copeland
authors.forename: S C
authors.initials: SC
authors.lastname: Clark
authors.forename: G G
authors.initials: GG
authors.lastname: Wong
authors.forename: S
authors.initials: S
authors.lastname: Rudikoff
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D004247:DNA / Q000302:isolation & purification; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D015850:Interleukin-6; D007378:Interleukins / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D015850:Interleukin-6; D007378:Interleukins; D004247:DNA