Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.
Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18-24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open.
Debler
E A
EA
Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, New York, NY 10035.
Lipovac
M N
MN
Lajtha
A
A
Zlokovic
B V
BV
Jacobson
A E
AE
Rice
K C
KC
Reith
M E
ME
D000161:Acoustic Stimulation; D000818:Animals; D007267:Injections; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D009915:Orbit; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000633:toxicity; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C044705:metaphit; D010622:Phencyclidine