Serum digoxin-like substances in pregnancy-induced hypertension.
1. Endogenous digoxin-like immunoreactivity (EDLI) was measured in the serum of 85 normotensive pregnant (NTP) women and 77 women with pregnancy-induced hypertension (PIH) by a radioimmunoassay (New England Nuclear). All women were in the third trimester. 2. EDLI, which was undetectable in serum from non-pregnant women, was present in NTP and PIH and was significantly higher in PIH. EDLI correlated with gestational age in NTP, but not in PIH. 3. Ouabain-sensitive Na+ transport was estimated in normal peripheral blood leucocytes after incubation with sera from 50 NTP and 42 PIH women. Significant inhibition of active Na+ transport occurred only with the serum of hypertensive patients without proteinuria. 4. EDLI did not correlate with the effect of the sera on active Na+ transport. The radioimmunoassay therefore provides a poor index of Na+ transport inhibitory activity in PIH.
Poston
L
L
Department of Physiology, St Thomas' Hospital, London.
Morris
J F
JF
Wolfe
C D
CD
Hilton
P J
PJ
D001693:Biological Transport, Active; D001798:Blood Proteins / Q000032:analysis*; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D012503:Saponins; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase