Persistent viral DNA synthesis associated with an avian osteopetrosis-inducing virus.
Bone and red blood cell DNA was obtained from MAV-2(O) infected, osteopetrotic chickens and analyzed for the presence of integrated and unintegrated viral DNA. Results indicate that unintegrated MAV-2(O) DNA did not appear until after osteopetrotic lesions were well established. These observations lead us to conclude that, unlike some retroviral diseases, unintegrated viral DNA may not play a significant role in the pathogenesis of MAV-2(O) osteopetrosis. In addition, there was no evidence of a clonally derived tumor in the bone.
Aurigemma
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RE
Department of Microbiology, Colorado State University, Ft. Collins 80523.
Comstock
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Smith
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RE
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics* / Q000472:pathogenicity; D015139:Blotting, Southern; D002642:Chick Embryo; D015342:DNA Probes; D004279:DNA, Viral / Q000096:biosynthesis*; D010022:Osteopetrosis / Q000382:microbiology*; D015183:Restriction Mapping
D015342:DNA Probes; D004279:DNA, Viral