title: Combination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case observations.
abstract: Four patients with rheumatoid arthritis received a combination of methotrexate and sulfasalazine for a mean of 24 months (range 20-28 months). All 4 patients experienced clinical improvement, with a reduction in the number of involved joints and in morning stiffness. In all 3 patients who had previously taken methotrexate, we were able to reduce the dosage, and the prednisone dosage was reduced in 2 of 3 patients who had previously taken that drug. No serious toxicity was observed in any patient.
authors.affiliation: Department of Medicine, Montreal General Hospital, McGill University, Quebec, Canada.
authors.forename: J B
authors.initials: JB
authors.lastname: Shiroky
authors.forename: C S
authors.initials: CS
authors.lastname: Watts
authors.forename: C
authors.initials: C
authors.lastname: Neville
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D012460:Sulfasalazine / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D012460:Sulfasalazine; D008727:Methotrexate