Mode of delivery and lymphocyte beta 2-adrenoceptor density in parturients and newborns.
Twenty-six women with uncomplicated pregnancy at term were selected for the study. Nine had spontaneous vaginal delivery without medication, 8 elective caesarean section under epidural and 9 under general anaesthesia. The results clearly demonstrate that newborns have lower lymphocyte beta 2-adrenoceptor density than their mothers. In vaginally delivered newborns the lymphocyte beta 2-adrenoceptor density was 38%, in the caesarean section group with general anaesthesia 27%, and with epidural anaesthesia 22% lower than in the corresponding mother group. Vaginally delivered newborns have lower lymphocyte beta 2-adrenoceptor density than those delivered by caesarean section. A plausible explanation is the down-regulation of the beta 2-adrenoceptors during labour and delivery.
Santala
M
M
Department of Obstetrics and Gynaecology, Kuopio University Central Hospital, Finland.
D000328:Adult; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D036861:Delivery, Obstetric; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007743:Labor, Obstetric / Q000097:blood*; D008214:Lymphocytes / Q000032:analysis*; D009321:Natural Childbirth; D009638:Norepinephrine / Q000097:blood; D011247:Pregnancy; D011943:Receptors, Adrenergic, beta / Q000097:blood*
D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine