Influence of CGP 361A, propranolol and diazepam on autonomous reactions to different stressors.
1. To evaluate the influence of beta-blockers and minor tranquilizers on autonomous stress response, 40 healthy subjects selected with regard to personality traits were randomly assigned to 5 groups. 2. Mental arithmetic induced the most pronounced increase in heart rate (HR), blood pressure and epinephrine secretion. 3. Beta-blockers reduced HR increases due to mental stress, whereas the minor tranquilizer reduced skin conductance level throughout the whole trial. 4. Our data provide evidence that different structured situations induce specific response patterns that are differentially modified by beta-blockers and minor tranquilizer.
Albus
M
M
Psychiatric Hospital, University of Munich, FRG.
Zellner
A
A
Bondy
B
B
Müller-Spahn
F
F
Engel
R
R
Ackenheil
M
M
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001007:Anxiety; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004558:Electric Stimulation; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise; D010146:Pain; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011897:Random Allocation; D012016:Reference Values; D013315:Stress, Psychological / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C058392:isamoltane; D011433:Propranolol; D003975:Diazepam; D004837:Epinephrine