[The effect of immunoscintigraphy with monoclonal antibodies on assays of hormones and tumor markers. This is not the end of the matter!].
The use of monoclonal antibodies in medicine for in-vivo diagnostic methods and for therapeutic purposes will increase in the future. Although monoclonal antibodies possess a high specificity, the animal origin of these antibodies remains a problem. Repeated administration of animal monoclonal antibodies (in vivo) may induce the formation of human antibodies against these monoclonal antibodies. Because animal monoclonal antibodies are also used in laboratory assays (in vitro), the presence of human antibodies against these animal monoclonal antibodies may cause spuriously elevated or depressed results of these assays. The clinician should be alert to this possibility. A case history is presented to demonstrate the problem.
Janssen
J A
JA
Blankestijn
P J
PJ
Docter
R
R
Blijenberg
B G
BG
Lamberts
S W
SW
Krenning
E P
EP
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood*; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005189:False Positive Reactions; D006801:Humans; D006968:Hypersensitivity, Delayed; D008297:Male; D051379:Mice; D009377:Multiple Endocrine Neoplasia / Q000097:blood / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002116:Calcitonin
De invloed van immunoscintigrafie met monoklonale antilichamen op bepalingen van hormonen en tumormerkstoffen. Een muis met een staartje!