title: [Role of liposomes in the presentation of HIV envelope glycoprotein and the immune response in mice].
abstract: The role of antigen presentation in the induction of humoral as well as cell-mediated immune responses has been investigated by anchoring HIV-1 envelope glycoprotein (gp 160/120) into the phospholipidic bilayer of preformed liposomes to produce HIV-Immunosomes. HIV-Immunosomes induced high titres of HIV-specific antibodies when tested by ELISA, IFA and neutralization, whereas equal amounts of purified glycoprotein alone produced lower antibody response. Similarly, HIV-Immunosomes induced antigen-specific Interleukin-2 production and blastogenic response upon restimulation with the same antigen, in animals vaccinated with HIV-Immunosomes, whereas no secondary response was observed in animals vaccinated with equal amounts of purified gp 160/120. Taken together, these results underline the importance of antigen presentation in the establishment of an adequate immune status and show the potential of HIV-Immunosomes as vaccine against AIDS.
authors.affiliation: Institut Armand-Frappier, Université du Québec, Laval, P.Q., Canada.
authors.forename: L
authors.initials: L
authors.lastname: Thibodeau
authors.forename: M
authors.initials: M
authors.lastname: Chagnon
authors.forename: L
authors.initials: L
authors.lastname: Flamand
authors.forename: D
authors.initials: D
authors.lastname: Oth
authors.forename: L
authors.initials: L
authors.lastname: Lachapelle
authors.forename: C
authors.initials: C
authors.lastname: Tremblay
authors.forename: L
authors.initials: L
authors.lastname: Montagnier
mesh_terms: D000818:Animals; D000917:Antibody Formation; D004337:Drug Carriers; D015686:Gene Products, env / Q000008:administration & dosage / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D007111:Immunity, Cellular; D008081:Liposomes / Q000276:immunology*; D051379:Mice
chemical_list: D004337:Drug Carriers; D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D008081:Liposomes
vernacular_title: Rôle des liposomes dans la présentation de la glycoprotéine de l'enveloppe du VIH et la réponse immunitaire chez la souris.