title: Structural chromosome aberrations in lymphocytes from children previously treated for Wilms' tumor or Hodgkin's disease.
abstract: Nineteen children treated for Wilms' tumor (thirteen cases) or Hodgkin's disease (six cases) with cytostatic agents and/or radiotherapy were studied cytogenetically on lymphocytes cultivated from blood samples drawn after at least 1 year of complete remission after end of therapy. A reference group of children was matched for age, sex, and residence. The frequencies of sister chromatid exchange (5.4 versus 5.6 SCE/cell), and chromosome damage type gaps (6.6 versus 7.1%) and breaks (1.9 versus 1.9%) were not different in the two groups, but exchange type aberrations were more frequent in the patients (0.9 versus 0.06%). Fifty karyotypes were analyzed in all but two cases of Hodgkin's disease. The overall frequency of stable (3.1 versus 3.8%) and unstable (1.7 versus 1.4%) structural chromosome changes such as translocations, deletions, chromatid exchanges, and dicentrics were not different in the patient and the control groups. If the chromosome data reflect a general cancer risk, this risk cannot be considerably higher among the cancer-treated children.
authors.affiliation: Department of Genetics, Norwegian Radium Hospital, Montebello, Oslo.
authors.forename: A
authors.initials: A
authors.lastname: Brøgger
authors.forename: S
authors.initials: S
authors.lastname: Kolmannskog
authors.forename: R B
authors.initials: RB
authors.lastname: Nicolaysen
authors.forename: F
authors.initials: F
authors.lastname: Wesenberg
authors.forename: R
authors.initials: R
authors.lastname: Nygaard
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary; D011878:Radiotherapy / Q000009:adverse effects*; D012306:Risk; D012854:Sister Chromatid Exchange; D009396:Wilms Tumor / Q000628:therapy*