Role of beta-receptor in the radix Angelicae sinensis attenuated hypoxic pulmonary hypertension in rats.
Acute pulmonary hypertension was caused by inhalation of 5% O2 in rats. Pulmonary vascular resistance (PVR) increased, but heart rate (HR), cardiac output (CO) and carotid arterial pressure (CAP) were not obviously changed. After an intravenous administration of Radix Angelicae sinensis, the acute pulmonary hypertension induced by inhalation of 5% O2 could be attenuated, but this effect disappeared if propranolol was given before Radix Angelicae sinensis. In chronic experiments, the same results were obtained, but the protective effect of Radix Angelicae sinensis on heart function was not influenced by propranolol. It is suggested that Radix Angelicae sinensis might play a role by stimulating the beta 2-receptor in the prevention of acute and chronic hypoxic pulmonary hypertension. However, prevention of hypertrophy of the right ventricle and enhancement of heart function in chronic hypoxic rats might not be attributed to the beta 1-receptor in the heart.
Sun
R Y
RY
Yan
Y Z
YZ
Zhang
H
H
Li
C C
CC
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D000860:Hypoxia / Q000150:complications*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000318:Adrenergic beta-Agonists; D004365:Drugs, Chinese Herbal