[Medical therapy of peptic ulcer: problems and prospects].
In the last few years, several drugs have been proposed for the healing of peptic ulcers H2 receptor antagonists are probably the reference-drugs for their efficacy and safety. Acute treatment of peptic ulcer with cimetidine, ranitidine or famotidine gives a high healing rate: from 60% to 90%, depending on the location of the ulcer and the drug used. However, relapse after short-term treatment still remains frequent, and prophylaxis of recurrence must be decided. Long-term treatment with antisecretory drugs could be dangerous for changes of the gastric system, with nitrites and nitro-compounds occurrence, and for the risk of frequent relapses. Therefore, the role of mucus-barrier drugs and surgery must be reconsidered.
Trabucchi
E
E
Foschi
D
D
Belloli
P
P
Montorsi
F
F
Marchetti
V
V
Mariscotti
C
C
Diamantini
S
S
D055598:Chemical Phenomena; D002621:Chemistry; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D012008:Recurrence
D006635:Histamine H2 Antagonists
La terapia medica dell'ulcera peptica: problemi e prospettive.