[Evaluation of cetirizine and of terfenadine in the treatment of perennial allergic rhinitis].
Thirty patients suffering from perennial allergic rhinitis took part in a cross-over, double-blind study during which they were treated for 3 two-week periods with either 10 mg cetirizine nocte or 60 mg terfenadine given morning and evening, or with a placebo. Both the active products were found to significantly improve the symptoms when compared to placebo (p less than or equal to 0.001). Cetirizine helped to reduce the symptoms of a blocked nose to a significantly greater extent than terfenadine (p less than or equal to 0.05). A significantly larger number of patients (p less than or equal to 0.05) preferred cetirizine (17/30) to terfenadine (6/30). Four patients taking cetirizine, and six of those taking terfenadine, reported a mild sedative effect.
Boniver
R
R
Oto-rhino-laryngologie, Verviers, Belgique.
Arendt
C
C
D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D017332:Cetirizine; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D016593:Terfenadine
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D016593:Terfenadine; D017332:Cetirizine
Evaluation de la cetirizine et de la terfenadine dans le traitement de la rhinite allergique perannuelle.