Lipolytic response of bovine adipose tissue to alpha and beta adrenergic agents 30 days pre- and 120 days postpartum.
1. The beta adrenergic agonists isoproterenol and epinephrine stimulated in vitro lipolysis in adipose tissue removed from heifers 30 days pre- and 120 days postpartum. 2. Propranolol, a beta antagonist, blocked isoproterenol stimulated lipolysis pre- and postpartum. 3. Epinephrine co-incubated with propranolol resulted in a suppression of lipolysis similar to that produced by clonidine, an alpha agonist, both pre- and postpartum. 4. Bovine adipose tissue lipolysis was more responsive to isoproterenol and isoproterenol + propranolol at 120 days of lactation than 30 days prepartum. 5. Adipose tissue sensitivity to clonidine, epinephrine and epinephrine + propranolol did not differ 30 days pre- and 120 days postpartum.
Smith
D J
DJ
Department of Animal Sciences, Washington State University, Pullman 99164-6320.
McNamara
J P
JP
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000375:Aging / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003000:Clonidine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005990:Glycerol / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D007774:Lactation / Q000187:drug effects; D008066:Lipolysis / Q000187:drug effects*; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D013566:Sympathomimetics; D011433:Propranolol; D007545:Isoproterenol; D003000:Clonidine; D005990:Glycerol; D004837:Epinephrine