title: Growth factor signaling pathways: phosphoinositide metabolism and phosphorylation of phospholipase C.
abstract: Recent demonstrations of growth factor-stimulated increases in cellular phosphoinositide metabolism suggest that regulatory enzymes of this important signaling pathway may be substrates for growth factor receptor tyrosine kinases. Studies employing phosphotyrosine antibodies, specific phospholipase C antibodies, and purified phospholipase C proteins support the conclusion that the 145-kD phospholipase C-gamma 1 isoenzyme is rapidly and selectively phosphorylated by the activated epidermal growth factor and platelet-derived growth factor receptors. The selective interaction of these receptors with phospholipase C-gamma 1 suggests a novel, direct mechanism for agonist stimulation of phosphoinositide metabolism.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
authors.forename: M I
authors.initials: MI
authors.lastname: Wahl
authors.forename: S
authors.initials: S
authors.lastname: Nishibe
authors.forename: G
authors.initials: G
authors.lastname: Carpenter
mesh_terms: D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D006133:Growth Substances; D010716:Phosphatidylinositols; D010738:Type C Phospholipases