title: Molecular cloning of SIV from sooty mangabey monkeys.
abstract: We derived two infectious molecular clones of SIV from sooty mangabey monkeys (Cercocebus atys) and compared them by restriction enzyme mapping and limited DNA sequencing to other known primate lentiviruses. These analyses show that SIVsmm is closely related to, but distinct from, SIVmac and HIV-2. Our data suggest that SIVmac may have been derived from SIVsmm by cross-species transmission in captivity.
authors.affiliation: Department of Microbiology, Georgetown University, Washington, DC.
authors.forename: V M
authors.initials: VM
authors.lastname: Hirsch
authors.forename: G
authors.initials: G
authors.lastname: Dapolito
authors.forename: C
authors.initials: C
authors.lastname: McGann
authors.forename: R A
authors.initials: RA
authors.lastname: Olmsted
authors.forename: R H
authors.initials: RH
authors.lastname: Purcell
authors.forename: P R
authors.initials: PR
authors.lastname: Johnson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D015153:Blotting, Western; D002460:Cell Line; D002520:Cercopithecidae / Q000382:microbiology*; D003001:Cloning, Molecular; D003429:Cross Reactions; D004279:DNA, Viral / Q000235:genetics; D008992:Monkey Diseases / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012192:Retroviridae Infections / Q000382:microbiology / Q000662:veterinary*; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification; D014162:Transfection
chemical_list: D004279:DNA, Viral