Cholinergic neuromodulation by endothelin in guinea pig ileum.
The effect of endothelin on cholinergic neuroeffector transmission in guinea pig ileum was investigated. Endothelin was shown to inhibit the nerve-induced contractions and concomitantly to increase the basal muscle tone. Furthermore, endothelin inhibited the nerve-induced release of [3H]acetylcholine whereas the contractile response to exogenous acetylcholine was enhanced. In conclusion, our findings suggest that endothelin is a modulator of cholinergic neuroeffector transmission in guinea pig ileum with possible action via both inhibitory prejunctional and stimulatory postjunctional mechanisms.
Wiklund
N P
NP
Department of Physiology, Karolinska Institutet, Stockholm, Sweden.
Wiklund
C U
CU
Ohlén
A
A
Gustafsson
L E
LE
D000109:Acetylcholine / Q000493:pharmacokinetics; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004558:Electric Stimulation; D016232:Endothelins; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000294:innervation*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D016232:Endothelins; D010455:Peptides; D014662:Vasoconstrictor Agents; D000109:Acetylcholine