Breast carcinoma with positive results for melanoma marker (HMB-45). HMB-45 immunoreactivity in normal and neoplastic breast.
HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity has been detected by the immunoperoxidase technique in the cytoplasm of 2 of 100 breast carcinomas. In addition, normal breast lobules and ducts were occasionally found to have positive results in 6 of 100 cases. These findings indicate the need to exercise caution in the interpretation of HMB-45 immunoreactivity for immunohistochemical characterization of neoplasms.
Bonetti
F
F
Istituto di Anatomia Patologica, Universitá di Verona, Italy.
Colombari
R
R
Manfrin
E
E
Zamboni
G
G
Martignoni
G
G
Mombello
A
A
Chilosi
M
M
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D001940:Breast / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis* / Q000473:pathology; D005260:Female; D005348:Fibrocystic Breast Disease / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008544:Melanocytes / Q000032:analysis*; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor