Effect of atrial natriuretic factor on angiotensin converting enzyme.
We studied the effects of atrial natriuretic factor on the conversion of angiotensin I to angiotensin II. Atrial natriuretic factor had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 1.22 nmol/min/dish of [125I]angiotensin I to II in the absence of atrial natriuretic factor, but this activity was suppressed by atrial natriuretic factor. When atrial natriuretic factor was added to pulmonary artery endothelial cells, the conversion of angiotensin I to angiotensin II was suppressed 0.475 nmol/min/dish at 10(-6) M of atrial natriuretic factor.
Kawaguchi
H
H
Department of Cardiovascular Medicine, Hokkaido University, School of Medicine, Sapporo, Japan.
Sawa
H
H
Yasuda
H
H
D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000096:biosynthesis*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011651:Pulmonary Artery; D014664:Vasodilation
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A