title: Beta blockade to decrease silent myocardial ischemia during peripheral vascular surgery.
abstract: The incidence and duration of intraoperative silent myocardial ischemia have been shown to be significantly correlated with the incidence of perioperative myocardial infarction in patients undergoing peripheral vascular surgery. To assess the effectiveness of intraoperative beta blockade in limiting such silent myocardial ischemia, a group of 48 patients was treated with oral metoprolol immediately prior to peripheral vascular surgery. The total duration of intraoperative silent myocardial ischemia, the percentage of intraoperative time silent myocardial ischemia was present, the number of intraoperative episodes of silent myocardial ischemia, and the intraoperative heart rate in the treated patients were compared with those in 152 similar but untreated peripheral vascular surgery patients. The patients treated with oral metoprolol had significantly less intraoperative silent ischemia with respect to relative duration and frequency of episodes, a significantly lower intraoperative heart rate, and less intraoperative silent myocardial ischemia in terms of total absolute duration. These results suggest that beta-adrenergic activation may play a major role in the pathogenesis of silent myocardial ischemia during peripheral vascular surgery.
authors.affiliation: Department of Medicine, New York University Medical Center, New York 10016.
authors.forename: P F
authors.initials: PF
authors.lastname: Pasternack
authors.forename: E A
authors.initials: EA
authors.lastname: Grossi
authors.forename: F G
authors.initials: FG
authors.lastname: Baumann
authors.forename: T S
authors.initials: TS
authors.lastname: Riles
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamparello
authors.forename: G
authors.initials: G
authors.lastname: Giangola
authors.forename: L K
authors.initials: LK
authors.lastname: Primis
authors.forename: R
authors.initials: R
authors.lastname: Mintzer
authors.forename: A M
authors.initials: AM
authors.lastname: Imparato
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007431:Intraoperative Complications / Q000188:drug therapy; D008790:Metoprolol / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol