title: [Interaction of the ligand molecules with the membrane receptors of tumor cells].
abstract: The mechanism of the ligand molecule interaction with cell membrane receptors is considered. The equation is obtained which describes dynamics of change in the number of ligand-receptor complexes on membranes with their constant internalization. It is shown that the in vivo internalization leads to saturation of the cell surface with the ligand-receptor complexes, the ligand concentrations being less than Kd. Theoretical conclusions are compared with the experimental data.
authors.forename: S D
authors.initials: SD
authors.lastname: Kaz'min
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008024:Ligands; D008433:Mathematics; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface
vernacular_title: Vzaimodeĭstvie molekul liganda s retseptorami membran opukholevykh kletok.