title: Effects of induction of anti-embryonation immunity on liver granulomas, spleen weight and portal pressure in mice infected with Schistosoma japonicum.
abstract: BALB/c mice sensitized with injections of viable immature Schistosoma japonicum eggs had significantly fewer and smaller granulomas in the liver, lower portal pressure and smaller spleens at D + 75 of infection compared to similarly infected unsensitized controls. The portal pressure and spleen weights of the mice sensitized with immature eggs were not different from uninfected unsensitized mice of similar ages at D + 75 of infection. The results strongly support our hypothesis that it should be possible to prevent serious hepatosplenic disease in schistosomiasis japonica by vaccination to induce anti-embryonation immunity.
authors.affiliation: Department of Parasitology, College of Public Health, University of the Philippines, Manila.
authors.forename: E G
authors.initials: EG
authors.lastname: Garcia
authors.forename: P T
authors.initials: PT
authors.lastname: Rivera
authors.forename: G F
authors.initials: GF
authors.lastname: Mitchell
authors.forename: R R
authors.initials: RR
authors.lastname: Evardome
authors.forename: R E
authors.initials: RE
authors.lastname: Almonte
authors.forename: W U
authors.initials: WU
authors.lastname: Tiu
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D006099:Granuloma / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D007114:Immunization; D008099:Liver / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D011168:Portal System / Q000503:physiopathology; D011817:Rabbits; D012554:Schistosomiasis japonica / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D012908:Snails; D013154:Spleen / Q000473:pathology