Cytomembranous inclusions in the peripheral nerves in AIDS.
We report finding tubuloreticular inclusions (TRI) in the endothelial cells of endo- and epineurial vessels in the sural nerve of 11 patients with AIDS. Six patients had a painful peripheral neuropathy, one a non-painful sensory neuropathy, one an acute inflammatory demyelinating polyradiculoneuropathy and one a thalidomide-related neuropathy. Two patients had no clinical evidence of neuropathy. The TRI are not specific to one neuropathy and are unlikely to contribute to the pathogenesis of peripheral nerve syndromes in AIDS.
Fuller
G N
GN
Department of Neuropathology, Institute of Neurology, Queen Square, London, Great Britain.
Jacobs
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D010525:Peripheral Nerves / Q000648:ultrastructure*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology*