XbaI restriction fragment length polymorphism of apolipoprotein B in Swedish myocardial infarction patients.
Apolipoprotein B (apoB) is a major importance to the metabolism of lipoproteins, and there is also evidence which suggests that apoB plays a central role in atherogenesis. In order to study whether there is a link between one of the mutations of the apoB gene and premature coronary heart disease, the frequency of the XbaI RFLP for the apoB gene was analysed in 52 male myocardial infarction patients. These were compared with a control group matched for age and sex (n = 52), and a random population sample of middle-aged men (n = 106). Two alleles were identified by the presence (X2) or the absence (X1) of an XbaI cleavage site. A somewhat higher frequency of the X2 allele was seen among the patients, however there was no significant difference between patients and controls regarding the genotypes or allele frequencies. This observation does not confirm one earlier report where a higher frequency of the X1 allele was seen in myocardial infarction patients. Differences between the studied populations or epidemiological designs of the studies might explain the diverging results. Further studies are evidently needed to fully resolve the relation between the XbaI RFLP and risk of atherosclerotic disease or lipoprotein metabolism.
Wiklund
O
O
Department of Medicine I, Gothenburg University, Sweden.
Darnfors
C
C
Bjursell
G
G
Nilsson
J
J
Linde'n
T
T
Olofsson
S O
SO
Wilhelmsen
L
L
Bondjers
G
G
D000328:Adult; D000483:Alleles; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics; D001055:Apolipoproteins B / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D005787:Gene Frequency; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013548:Sweden
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008074:Lipoproteins; C025580:endodeoxyribonuclease XBAI; D015252:Deoxyribonucleases, Type II Site-Specific