Neuropathy in IgM lambda paraproteinemia. Immunoreactivity to neural proteins and chondroitin sulfate.
In axonal neuropathies associated with IgM paraproteinemia, reports of antigen specificity of the M-protein are few. A patient with IgM paraproteinemia presented with progressive mononeuritis multiplex. IgM was found deposited in striking amounts in endoneurium and shown to bind specifically to neural proteins and chondroitin sulfates. Direct immune mechanisms, as well as the physical effects of IgM deposition, likely contributed to the development of the neuropathy.
Yee
W C
WC
Department of Medicine, Health Sciences Center, Winnipeg, Manitoba, Canada.
Hahn
A F
AF
Hearn
S A
SA
Rupar
A R
AR
D000368:Aged; D002809:Chondroitin Sulfates / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology* / Q000473:pathology; D010525:Peripheral Nerves / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000473:pathology; D012016:Reference Values
D007075:Immunoglobulin M; D009419:Nerve Tissue Proteins; D002809:Chondroitin Sulfates