[Pagetoid reticulosis of the Ketron-Goodman type].
The case of a 79-year-old woman with widespread pagetoid reticulosis (Ketron-Goodman type) is presented. The nature of the epidermal cellular infiltrate in pagetoid reticulosis of the Ketron-Goodman type was examined by immunohistochemical methods and by electron microscopy. On ultrastructural examination the infiltrating cells proved to be medium-sized and large Sézary-type and blastoid cells. Immunohistochemically, the epidermal infiltrate was composed of approximately 80% immature T cells (OKT 16) and 30% proliferating cells (Ki 67). Mature T cells (CD 5) were found to account for only 15-30% of all cells in the infiltrate. These results suggest that pagetoid reticulosis (Ketron-Goodman type) is a malignant T-cell lymphoma, which is characterized, in addition to the epidermotropic behavior common to all T-cell lymphomas, by innidiation and in-situ spread within the epidermis.
Luther
H
H
Dermatologische Klinik, Ruhr-Universität Bochum.
Bacharach-Buhles
M
M
Schultz-Ehrenburg
U
U
Altmeyer
P
P
D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007642:Keratosis / Q000473:pathology*; D007801:Langerhans Cells / Q000473:pathology; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000473:pathology*; D010241:Parakeratosis / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
Pagetoide Retikulose vom Typ Ketron-Goodman.