Postexposure immunotherapy of simian immunodeficiency virus (SIV) infected rhesus with an SIV immunogen.
An inactivated whole simian immunodeficiency virus (SIV) immunogen given to healthy, seropositive rhesus macaques 4 months after infection had no effect on the humoral immune response to SIV, the presence of antigenemia, cell-associated viremia, or disease course. Further immunotherapeutic trials in this highly susceptible animal model should be carried out sooner after exposure, before significant loss of CD4 cells has occurred. The SIV infected macaque model will continue to serve an essential role in development and testing of anti-AIDS drugs and immunogens.
Gardner
M B
MB
Department of Medical Pathology, University of California, Davis.
Jennings
M
M
Carlson
J R
JR
Lerche
N
N
McGraw
T
T
Luciw
P
P
Marx
P
P
Pedersen
N
N
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004195:Disease Models, Animal; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000662:veterinary; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008992:Monkey Diseases / Q000276:immunology* / Q000628:therapy; D012192:Retroviridae Infections / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014766:Viremia / Q000662:veterinary
D000914:Antibodies, Viral