title: Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism.
abstract: Cyclic-disulfide-containing analogues of somatostatin, Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7- Xaa8 [Xaa1 = H or DPhe; Xaa3 = Phe or Tyr; Xaa7 = Cys, Me2Cys or Me2DCys; Xaa8 = OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H-NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.
authors.affiliation: Laboratory of Organic Chemistry, Vrije Universiteit Brussel, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Wynants
authors.forename: D
authors.initials: D
authors.lastname: Tourwe
authors.forename: W
authors.initials: W
authors.lastname: Kazmierski
authors.forename: V J
authors.initials: VJ
authors.lastname: Hruby
authors.forename: G
authors.initials: G
authors.lastname: Van Binst
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013004:Somatostatin / Q000031:analogs & derivatives*
chemical_list: D013004:Somatostatin