N-benzhydryl-tryptamines and 1,1-diphenyl-tetrahydro-beta-carbolines: synthesis, X-ray crystal structure and benzodiazepine receptor affinity.
Several N-benzhydryl-tryptamines and 1,1-diphenyl-tetrahydro-beta-carbolines were synthetized and the requisites for their formation were established. Crystallographic and conformational analyses were carried out on selected compounds and the affinity for the central benzodiazepine receptors was measured.
Balsamini
C
C
Istituto Di Chimica Farmaceutica, Università Di Urbino, Italy.
Spadoni
G
G
Duranti
E
E
Cerrini
S
S
Lamba
D
D
Fedeli
W
W
D000818:Animals; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D003975:Diazepam / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D014363:Tryptamines / Q000138:chemical synthesis* / Q000494:pharmacology; D014961:X-Ray Diffraction
D001559:Benzhydryl Compounds; D002243:Carbolines; D011963:Receptors, GABA-A; D014363:Tryptamines; D003975:Diazepam