[Amplification and expression of oncogenes in human malignant tumors--organ or tissue specificity and prognosis].
We investigated the amplification and expression of oncogenes in human cancerous and noncancerous tissues, and clarified the correlation between the biological characteristics and them. Amplification of c-erb B oncogene is detected in 12% of squamous cancer tissues such as cancer of the lung and esophagus, but not others. That of c-erb A and c-erb B-2 oncogenes is, specifically, detected in 20-25% of breast cancers. On the other hand, amplification of c-myc is detected in 10-20% of various cancers. EGF receptors is highly and specifically, overexpressed in squamous cancers, and the prognosis of the patients with amplification and overexpression of c-erb B oncogenes is poor.
Ueda
M
M
Dept. Surg. School of Medicine Keio University, Tokyo, Japan.
Shimizu
N
N
Abe
O
O
D066246:ErbB Receptors / Q000032:analysis; D005784:Gene Amplification; D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009928:Organ Specificity; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D011988:Receptors, Thyroid Hormone
D066246:ErbB Receptors; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011988:Receptors, Thyroid Hormone