The release of chromogranin A and B like activity from human lung cancer cell lines. A potential marker for a subset of small cell lung cancer.
Human small cell lung cancer (SCLC) is in vivo and in vitro characterized by a heterogeneous spectrum of neuroendocrine markers. The non-SCLC group is deprived of these markers, or expresses them in low quantities. In this paper we report on the release to the culture medium of neuroendocrine associated proteins, chromogranin A and B like activity (CABLA). The culture medium from three out of five SCLC cell lines and in one/five non-SCLC cell line contained significant levels of CABLA. Normal diploid foreskin fibroblasts and a histiocytic lymphoma cell line were deprived of CABLA production. The presence of CABLA in both SCLC and non-SCLC further stress their common histogenetic origin. The CABLA values were partly unrelated to other neuroendocrine markers. Determinations of CABLA could thus be a potential and valuable marker for a subset of SCLC.
Bergh
J
J
Department of Oncology, Ludwig Institute for Cancer Research, University of Uppsala, Akademiska Sjukhuset, Sweden.
Arnberg
H
H
Eriksson
B
B
Lundqvist
G
G
D014408:Biomarkers, Tumor / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D009419:Nerve Tissue Proteins