Haloperidol and cognitive shifting.
In this study haloperidol appeared to affect the performance on a selected category of cognitive tasks considered to represent shifting aptitude. A pretest--post-test design was used with two groups of subjects: 17 patients suffering from idiopathic spasmodic torticollis, and 17 controls who were matched for age and intelligence. The results are discussed in relation to previous findings on haloperidol and cognition, shifting disorder in Parkinson's disease and changes in behavioural organization found in animals with an experimentally induced dopaminergic hypoactivity.
Berger
H J
HJ
Department of Medical Psychology, University of Nijmegen, The Netherlands.
van Hoof
J J
JJ
van Spaendonck
K P
KP
Horstink
M W
MW
van den Bercken
J H
JH
Jaspers
R
R
Cools
A R
AR
D001288:Attention / Q000187:drug effects; D001479:Basal Ganglia / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014103:Torticollis / Q000188:drug therapy*; D014705:Verbal Behavior / Q000187:drug effects; D014706:Verbal Learning / Q000187:drug effects
D011954:Receptors, Dopamine; D006220:Haloperidol