title: Sequential combination of 5-fluorouracil, cis-platinum and irradiation in unresectable non-small cell lung cancer.
abstract: Twenty patients with unresectable non-small cell lung carcinoma, 15 stage III and 5 stage IV (supraclavicular lymphadenopathy) were treated with a combination of three courses of chemotherapy and hypofractionated irradiation followed after 3 weeks by split-course radiotherapy. Each course was repeated every 3 weeks with the following sequence. Cis-platin (CDDP) (20 mg/m2) was given in a 20-min infusion, followed by a 2-h infusion of 5-fluorouracil (5-FU) (400 mg/m2) on days 1, 2, 5 and 6. Radiation with a dose of 3 Gy on the target volume was given on days 3 and 4, after a 2-h infusion of 5-FU (400 mg/m2). Split course of irradiation consisted of 16 Gy in 5 fractions repeated after 3 weeks interval. The objective response rate was 75%. Median follow-up was 24 months, the median survival was 14 months. The 1-year survival was 53% and the 2-year survival was 16%.
authors.affiliation: Department of Pneumology, C.H.U. A. Michallon, Grenoble, France.
authors.forename: H
authors.initials: H
authors.lastname: Nagy-Mignotte
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.forename: B
authors.initials: B
authors.lastname: Wuyam
authors.forename: F
authors.initials: F
authors.lastname: Blanc-Jouvan
authors.forename: D
authors.initials: D
authors.lastname: Moro
authors.forename: C
authors.initials: C
authors.lastname: Brambilla
authors.forename: B
authors.initials: B
authors.lastname: Paramelle
authors.forename: F
authors.initials: F
authors.lastname: Vincent
authors.forename: H
authors.initials: H
authors.lastname: Kolodié
authors.forename: C
authors.initials: C
authors.lastname: Vrousos
mesh_terms: D000206:Actuarial Analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011882:Radiotherapy, High-Energy / Q000379:methods*; D015996:Survival Rate
chemical_list: D002945:Cisplatin; D005472:Fluorouracil