Yawning induced by the selective dopamine D2 agonist N-0437 is blocked by the selective dopamine autoreceptor antagonist (+)-UH 232.
Yawning and stretching responses were elicited in rats by a small dose (0.3 mg/kg) of the highly selective dopamine D2 agonist, N-0437. The responses were blocked by the highly selective dopamine autoreceptor antagonist, (+)-UH 232 (3.0 mg/kg), but not by raclopride at a dose which selectively blocks postsynaptic D2 receptors. The results strongly confirm the view that yawning and stretching are behavioral responses elicited by stimulation of presynaptic D2 receptors.
Cooper
S J
SJ
School of Psychology, University of Birmingham, United Kingdom.
Rusk
I N
IN
Barber
D J
DJ
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004347:Drug Interactions; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D020891:Raclopride; D051381:Rats; D012457:Salicylamides / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D013997:Time Factors; D015000:Yawning / Q000187:drug effects*
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D009281:Naphthalenes; D012457:Salicylamides; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; D020891:Raclopride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C047508:rotigotine; C045971:UH 232