[Effects of ethanol on the concentration of neuropeptides, ACTH and corticosterone during immobilization stress].
It was shown, that stress increased the level of ACTH, beta-endorphin and corticosterone in the blood plasma of the rat. Injection of ethanol (1 g/kg) decreased the level of ACTH, but increased the levels of beta-endorphin in the rat subjected to immobilization stress. The immobilization lowered the levels of met-enkephalin in the striatum and medulla oblongata, but increased the content of neuropeptide in the adrenal glands. The concentration of leu-enkephalin and DSIP remained unchanged following the stress. Ethanol reversed the action of immobilization on the level of met-enkephalin in the striatum, but increased the content of DSIP in the thalamus. These results indicate that ethanol modified the activity of pituitary-adrenal-axis during stress and probably the stress-protective action of ethanol partly performed with the involvement of DSIP.
Iukhananov
R Iu
RIu
Rozhanets
V V
VV
Maĭskiĭ
A I
AI
D000311:Adrenal Glands / Q000032:analysis; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D003345:Corticosterone / Q000097:blood*; D004745:Enkephalins / Q000032:analysis; D000431:Ethanol / Q000494:pharmacology*; D007103:Immobilization; D008297:Male; D009479:Neuropeptides / Q000032:analysis / Q000097:blood*; D051381:Rats; D013312:Stress, Physiological / Q000097:blood* / Q000503:physiopathology; D001615:beta-Endorphin / Q000097:blood
D004745:Enkephalins; D009479:Neuropeptides; D000431:Ethanol; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Vliianie étanola na kontsentratsiiu neĭropeptidov, AKTG i kortikosterona na fone immobilizatsionnogo stressa.