Plasma pancreastatin-like immunoreactivity in various diseases.
Plasma pancreastatin (PST)-like immunoreactivity in normal subjects and patients with various diseases was estimated by a RIA, using antiserum raised against a synthetic C-terminal peptide of human PST deduced from the sequence of human chromogranin-A. The mean level +/- SEM was 13.2 +/- 0.6 pmol/L in normal subjects, but was significantly higher in patients with chronic renal failure (526.7 +/- 48.5). An immunoreactive form corresponding to a human PST-like sequence [human chromogranin-A-(250-301)] and a larger form were detected by gel filtration of plasma from these patients, suggesting accumulation of the larger molecular form in these patients. A significant increase in PST-like immunoreactivity was also found in patients with liver cirrhosis (20.8 +/- 3.0 pmol/L), but not in patients with noninsulin-dependent diabetes mellitus, chronic pancreatitis, or pancreatic cancer. Elevated levels were found in 16 of the 21 patients with small cell lung carcinoma examined. High levels were also found in 3 of 11 patients with islet cell tumor.
Tateishi
K
K
First Department of Biochemistry, Fukuoka University School of Medicine, Japan.
Funakoshi
A
A
Wakasugi
H
H
Iguchi
H
H
Shinozaki
H
H
Abe
M
M
Funakoshi
S
S
Tamamura
H
H
Yajima
H
H
Matsuoka
Y
Y
D007516:Adenoma, Islet Cell / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002277:Carcinoma / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood; D053379:Chromogranin A; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D007674:Kidney Diseases / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood; D010187:Pancreatic Hormones / Q000097:blood*; D010190:Pancreatic Neoplasms / Q000097:blood*; D010195:Pancreatitis / Q000097:blood; D011863:Radioimmunoassay / Q000379:methods; D012016:Reference Values
D015415:Biomarkers; D053379:Chromogranin A; D010187:Pancreatic Hormones; C050836:pancreastatin