The clinical utility of pharmacological agents that act at serotonin receptors.
The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.
Peroutka
S J
SJ
Department of Neurology, Stanford University, CA 94305.
Sleight
A J
AJ
McCarthy
B G
BG
Pierce
P A
PA
Schmidt
A W
AW
Hekmatpanah
C R
CR
D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D011619:Psychotropic Drugs; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin