Leukotriene metabolism and hypersensitivity in man and mouse.
The relative rates of cysteinyl-leukotriene metabolism were analyzed in fresh human and mouse serum. Human serum contained higher gamma-glutamyl-transpeptidase activity than mouse serum, and a higher percentage of the metabolized leukotriene C4 was recovered as leukotriene D4 in the human serum than in the mouse serum. The results suggest that the patterns of metabolism of the cysteinyl-leukotrienes could be an important factor in determining the relative sensitivity of an animal to the development of hypersensitivity reactions.
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Division of Biological Sciences, University of Montana, Missoula 59812.
Unnithan
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Rhodes
M J
MJ
Wright
B E
BE
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006967:Hypersensitivity; D015289:Leukotrienes / Q000097:blood* / Q000302:isolation & purification; D051379:Mice; D013189:SRS-A / Q000097:blood*; D013045:Species Specificity; D005723:gamma-Glutamyltransferase / Q000097:blood
D015289:Leukotrienes; D013189:SRS-A; D005723:gamma-Glutamyltransferase