title: [Effect of estroprogestative drugs on the secretion of corticoadrenal hormones].
abstract: Estro-progestative drugs (EPD) have been used for many years and multiple secondary effects have been reported concerning mainly the glucidic and lipidic metabolisms. Effects of EPD on steroid metabolism have also been described and the authors present a review of the literature on this subject. Particularly it appears that EPD affect: the glucocorticoid metabolism, with augmentation of total cortisol although not in its free-form (augmentation of transcortine), the adrenal androgens metabolism, with diminution of their circulating rates, the aldosterone metabolism with augmentation of its secretion. These biological constatations could help explaining some clinical features occurring with administration of EPD: diminution of hirsutism and/or acne, augmentation of body weight, appearance of hypertension.
authors.affiliation: Laboratoire de Biochimie, UFR de Pharmacie, Amiens.
authors.forename: C
authors.initials: C
authors.lastname: Lemay
authors.forename: R
authors.initials: R
authors.lastname: Julien
authors.forename: J L
authors.initials: JL
authors.lastname: Brérault
authors.forename: J
authors.initials: J
authors.lastname: Fiet
authors.forename: M N
authors.initials: MN
authors.lastname: Gounaud
authors.forename: R
authors.initials: R
authors.lastname: Bonete
authors.forename: B
authors.initials: B
authors.lastname: Gueux
authors.forename: J M
authors.initials: JM
authors.lastname: Villette
authors.forename: P
authors.initials: P
authors.lastname: Vexiau
authors.forename: C
authors.initials: C
authors.lastname: Dreux
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism / Q000502:physiology*; D000311:Adrenal Glands / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000728:Androgens / Q000502:physiology; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D011374:Progesterone / Q000031:analogs & derivatives / Q000494:pharmacology*; D011372:Progestins / Q000494:pharmacology*
chemical_list: D000305:Adrenal Cortex Hormones; D000728:Androgens; D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D011372:Progestins; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
vernacular_title: Influence des estroprogestatifs sur la sécrétion des hormones corticosurrénaliennes.