[Isolation of recombinant vaccine strains of poliovirus from patients with poliomyelitis].
Oligonucleotide maps of some poliovirus type 2 strains isolated from polio cases, while being clearly related to that of the Sabin vaccine type 2 strain, exhibited, nevertheless, marked differences from the reference (vaccine) map. Several large oligonucleotides derived from 4 such strains were subjected to enzymatic sequencing. The results strongly suggest that all of them were intertypic recombinants between the Sabin strains. The 5'-parts of the genomes of these strains were derived from the type 2 vaccine whereas the 3'-parts were of type 1 (in 2 strains) or type 3 (in other 2 strains) origin.
Kutitova
O K
OK
Lipskaia
G Iu
GIu
Maslova
S V
SV
Agol
V I
VI
D001483:Base Sequence; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D011051:Poliomyelitis / Q000382:microbiology*; D017955:Poliovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic
D011055:Poliovirus Vaccine, Oral; D012367:RNA, Viral
Vydelenie rekombinantov mezhdu vaktsinnymi shtammami poliovirusa ot bol'nykh poliomielitom.