[C-src locus determines increased rate of Na+,K+-cotransport and increased calcium content in erythrocytes of (SHR x WKY) F2 hybrids].
26 male F2 hybrids between spontaneously hypertensive (SHR) and normotensive control (WKY) rats (SHRxWKY)F2 were segregated according to their c-src genotype into SS and WW homozygous groups, corresponding to SHR or WKY and WS heterozygous group. Na, K cotransport in erythrocytes in the WW group was equal to that of WKY and differs significantly from that of WS and SS groups (the rate of Na, K cotransport in latter groups was close to that of SHR). Ca content of RBC in WW group was equal to that of WKY, lower than that of WS and SS groups which in turn was significantly lower than in SHR, indicating polygenic control of the trait. Authors conclude that the c-src locus itself or some other loci inherited in conjunction with c-src determines both the increase of Na, K cotransport and calcium content in erythrocytes of SHR.
Kotelevtsev
Iu V
IuV
Spitkovskiĭ
D D
DD
Orlov
S N
SN
Postnov
Iu V
IuV
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000097:blood*; D002874:Chromosome Mapping; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006824:Hybridization, Genetic; D008297:Male; D009857:Oncogenes; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium
Lokus c-src opredeliaet uvelichennuiu skorost' Na+,K+-kotransporta i povyshennoe soderzhanie kal'tsiia v éritrotsitakh gibridov (SHR x WKY) F2.