Mutagenicity of the human carcinogen treosulphan in Salmonella.
The human carcinogen treosulphan was mutagenic in Salmonella typhimurium TA100 and TA1535, as was dl-1,2:3,4-diepoxybutane (DEB), a proposed hydrolysis product of treosulphan. Another proposed hydrolysis product, methane- sulfonic acid, was not mutagenic in these strains. The pattern of the mutagenic responses at pH 6,7, and 8 to treosulphan and DEB suggests that DEB formation may be responsible for the mutagenicity of treosulphan.
Zeiger
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Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Pagano
D A
DA
D002066:Busulfan / Q000031:analogs & derivatives* / Q000633:toxicity; D002273:Carcinogens; D004852:Epoxy Compounds / Q000633:toxicity; D006868:Hydrolysis; D008698:Mesylates / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics*
D002273:Carcinogens; D004852:Epoxy Compounds; D008698:Mesylates; D009153:Mutagens; C007366:diepoxybutane; C018404:treosulfan; D002066:Busulfan