Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.
We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28. X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. DXS374--and therefore GABRA3--lies distal to the fragile X locus at a recombination fraction of approximately .15.
Bell
M V
MV
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England.
Bloomfield
J
J
McKinley
M
M
Patterson
M N
MN
Darlison
M G
MG
Barnard
E A
EA
Davies
K E
KE
D015342:DNA Probes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D001523:Mental Disorders / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011963:Receptors, GABA-A / Q000235:genetics*; D015183:Restriction Mapping; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers; D011963:Receptors, GABA-A