title: An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man.
abstract: Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha 2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha 2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha 2 antagonist.
authors.affiliation: Institute of Psychiatry, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Palazidou
authors.forename: A
authors.initials: A
authors.lastname: Papadopoulos
authors.forename: A
authors.initials: A
authors.lastname: Sitsen
authors.forename: S
authors.initials: S
authors.lastname: Stahl
authors.forename: S
authors.initials: S
authors.lastname: Checkley
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D008803:Mianserin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D000078785:Mirtazapine
chemical_list: D000317:Adrenergic alpha-Antagonists; D008803:Mianserin; D000078785:Mirtazapine; D008550:Melatonin