title: MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.
abstract: The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C receptor subtype to increase ACTH.
authors.affiliation: UCLA Neuropsychiatric Institute 90024.
authors.forename: B H
authors.initials: BH
authors.lastname: King
authors.forename: C
authors.initials: C
authors.lastname: Brazell
authors.forename: C T
authors.initials: CT
authors.lastname: Dourish
authors.forename: D N
authors.initials: DN
authors.lastname: Middlemiss
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D013134:Spiperone / Q000494:pharmacology
chemical_list: D000978:Antiparkinson Agents; D004873:Ergolines; D010879:Piperazines; D011719:Pyrazines; D011985:Receptors, Serotonin; D008711:Metergoline; D013134:Spiperone; C014896:6-chloro-2-(1-piperazinyl)pyrazine; D000324:Adrenocorticotropic Hormone; D007650:Ketanserin; D010869:Pindolol; C015068:1-(3-chlorophenyl)piperazine; C031649:mesulergine