[Effect of ionizing radiation at high doses on the cyclic nucleotide content of the rat brain].
The study of the rat brain after irradiation with superlethal doses of 100 and 500 Gy has revealed a decrease in the cAMP content at early times after exposure. The most considerable decline in the cGMP content was noted in the cerebellum and cerebral hemisphere cortex where low cGMP level was retained for 24 h following irradiation. It is suggested that the observed changes play an important role in the development of the CNS syndrome.
Sharova
L A
LA
D000818:Animals; D001923:Brain Chemistry / Q000528:radiation effects*; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism; D000242:Cyclic AMP / Q000032:analysis / Q000528:radiation effects*; D006152:Cyclic GMP / Q000032:analysis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D008297:Male; D010315:Particle Accelerators; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D013997:Time Factors
D000242:Cyclic AMP; D006152:Cyclic GMP
Vliianie ioniziruiushchikh izlucheniĭ v vysokikh dozakh na soderzhanie tsiklicheskikh nukleotidov v golovnom mozge krys.