Chronic septal lesions cause upregulation of cholinergic but not noradrenergic hippocampal phosphoinositide hydrolysis.
The functional integrity of hippocampal muscarinic and noradrenergic receptors was assessed utilizing phosphatidyl inositol (PI) hydrolysis. Four months following septal lesions an enhanced hippocampal PI response to carbachol stimulation (61%) was observed while no effect was found in maximal noradrenergic stimulation.
Connor
D J
DJ
Department of Neurology, Veterans Administration Medical Center, Birmingham, AL 35294.
Harrell
L E
LE
D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
D010716:Phosphatidylinositols; D002217:Carbachol; D009638:Norepinephrine