title: Two newly identified human papillomavirus types (HPV 40 and 57) isolated from mucosal lesions.
abstract: Two new papillomaviruses, HPV 40 and HPV 57, were isolated from a PIN lesion and an inverted papilloma of the maxillary sinus, respectively. HPV 40 showed a 13% homology to HPV 7 by reassociation kinetics and HPV 57 showed a 17% homology to HPV 2 and 25% homology to HPV 27. Hybridization of the DNA of these papillomaviruses to a wide variety of different tumor biopsies revealed that HPV 40 was present in a few genital condylomata acuminata as well as in bowenoid lesions. HPV 57 DNA was present in an oral wart, a genital condyloma acuminatum, and verrucae vulgares lesions from two immunosuppressed patients.
authors.affiliation: Referenzzentrum für humanpathogene Papillomviren, Deutsches Krebsforschungszentrum, Heidelberg, West Germany.
authors.forename: E M
authors.initials: EM
authors.lastname: de Villiers
authors.forename: A
authors.initials: A
authors.lastname: Hirsch-Behnam
authors.forename: C
authors.initials: C
authors.lastname: von Knebel-Doeberitz
authors.forename: C
authors.initials: C
authors.lastname: Neumann
authors.forename: H
authors.initials: H
authors.lastname: zur Hausen
mesh_terms: D003218:Condylomata Acuminata / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D010212:Papilloma / Q000382:microbiology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D010412:Penile Neoplasms / Q000382:microbiology; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014625:Vaginal Neoplasms / Q000382:microbiology
chemical_list: D004279:DNA, Viral