title: [Acute lymphoblastic Ph1-positive leukemia with a hybrid phenotype. The significance of the Ph1 anomaly and the hybrid phenotype].
abstract: The present paper reports on a case of acute lymphoblastic leukemia with t(9q+; 22q-) and surface markers specific of the B and T lymphoid line (hybrid phenotype). The fundamental (genotypical and phenotypical) and practical aspects (nosologic and therapeutical aspects) of this particular subtype of Ph1-positive acute leukemia and hybrid phenotype are discussed.
authors.forename: S
authors.initials: S
authors.lastname: Nicoară
authors.forename: D
authors.initials: D
authors.lastname: Stefănescu
authors.forename: S
authors.initials: S
authors.lastname: Roman
authors.forename: F
authors.initials: F
authors.lastname: Tudor
authors.forename: E
authors.initials: E
authors.lastname: Butoianu
authors.forename: C
authors.initials: C
authors.lastname: Ursea
authors.forename: A
authors.initials: A
authors.lastname: Petrescu
authors.forename: S
authors.initials: S
authors.lastname: Berceanu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002869:Chromosome Aberrations; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005838:Genotype; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D010641:Phenotype; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics
vernacular_title: Leucemia acută limfoblastică Ph1 pozitivă cu fenotip hibrid. Semnificaţia anomalie Ph1 şi a fenotipului hibrid.