title: [A quantitative evaluation of brain computerized tomography in children using color image analyzer].
abstract: We attempted the quantitative analysis of brain computerized tomographic scans in children using Color Image Analyzer. A consecutive series of 167 computerized tomographic scans were reviewed. Areas of subarachnoid spaces, cavums, ventricles and cerebellums were measured on three slices: A slice is at the level of head of caudate nucleus, anterior horn of lateral ventricle and third ventricle. B slice is at the level of body of lateral ventricle. C slice is at the level of sella turcica and pons. We investigated these values compared with Evans ratio, Cella Media Index, cerebellar atrophy score and visually evaluations. Serial brain CT scans of eight patient with infantile spasms were also evaluated for the assessment of the brain shrinkage after ACTH therapy. 1) The ratios of the subarachnoid space/the intracranial area on A and B slices (SAS A%, SAS B%) were significantly higher in the patients of severe brain atrophy. 2) There were linear relationship between Evans ratio and SAS A% (r = 0.405, p less than 0.001), Cella Media Index and the ratio of the lateral ventricles/the intracranial areas on B slice (r = -0.501, p less than 0.001), and the cerebellar atrophy score by Une and SAS C% (r = 0.369, p less than 0.001). 3) In the normal patients, the values of SAS A% and SAS B% were much greater in less than 1.5 years old children. These results suggest that the trend of CT findings related to age may reflect physiological changes of the space between the skull and the brain with age. 4) Brain shrinkage after ACTH therapy was more pronounced in the subarachnoid space than the ventricle.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamatani
authors.forename: Y
authors.initials: Y
authors.lastname: Naganuma
authors.forename: K
authors.initials: K
authors.lastname: Hongoh
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Okada
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000367:Age Factors; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology; D014695:Cerebral Ventriculography; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D012016:Reference Values; D013036:Spasms, Infantile / Q000188:drug therapy; D013346:Subarachnoid Space / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000324:Adrenocorticotropic Hormone