title: Chronic septal lesions cause upregulation of cholinergic but not noradrenergic hippocampal phosphoinositide hydrolysis.
abstract: The functional integrity of hippocampal muscarinic and noradrenergic receptors was assessed utilizing phosphatidyl inositol (PI) hydrolysis. Four months following septal lesions an enhanced hippocampal PI response to carbachol stimulation (61%) was observed while no effect was found in maximal noradrenergic stimulation.
authors.affiliation: Department of Neurology, Veterans Administration Medical Center, Birmingham, AL 35294.
authors.forename: D J
authors.initials: DJ
authors.lastname: Connor
authors.forename: L E
authors.initials: LE
authors.lastname: Harrell
mesh_terms: D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
chemical_list: D010716:Phosphatidylinositols; D002217:Carbachol; D009638:Norepinephrine