Role of Mg in the activation of Na-H exchange in dog red cells.
Depleting dog red cells of Mg prevents activation of Na-H exchange by cell shrinkage but has no effect on activation by acidification of the cytosol. Replacing cell Mg restores the activation of Na-H exchange by cell shrinking. We conclude that Mg is required, not for the transport process per se, but for the transduction of the volume stimulus.
Parker
J C
JC
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Gitelman
H J
HJ
McManus
T J
TJ
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002352:Carrier Proteins / Q000097:blood*; D004285:Dogs; D004492:Edetic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology / Q000502:physiology*; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers; D000001:Calcimycin; D000584:Amiloride; D004492:Edetic Acid; D012964:Sodium; D008274:Magnesium