Localization of dynorphin-induced neurotoxicity in rat spinal cord.
Intrathecally injected dynorphin A (1-13) in rats results in a reversible hindlimb paralysis and an irreversible loss of the tail-flick reflex. Histologic examination of the spinal cords of dynorphin treated rats demonstrated dead and/or dying neurons predominately localized in the central area which approximates Rexed lamina VII and X. In this area a maximum effect of the dynorphin-induced neurotoxicity is evident. Thus, the dynorphin-induced neuron death is suggestive of an anatomical selectivity.
Stewart
P
P
Department of Occupational Therapy, College of Associated Health Professions, University of Illinois, Chicago 60612.
Isaac
L
L
D000818:Animals; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004399:Dynorphins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000473:pathology; D010146:Pain; D010243:Paralysis / Q000139:chemically induced; D010446:Peptide Fragments / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000473:pathology
D010446:Peptide Fragments; C026843:dynorphin (1-13); D004399:Dynorphins