[A method of determining fragments of peptide bioregulators responsible for interaction with receptors].
A method for investigating the relationship between chemical structure of peptide molecules and their biological activity is suggested. It is based on a few statistical algorithms which are described. The results of the method testing on the thyrotropin-releasing hormone analogs are presented.
Golubovich
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VP
Drboglav
V V
VV
D000465:Algorithms; D001665:Binding Sites; D010446:Peptide Fragments / Q000502:physiology; D011487:Protein Conformation; D011956:Receptors, Cell Surface; D013329:Structure-Activity Relationship; D013973:Thyrotropin-Releasing Hormone
D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D013973:Thyrotropin-Releasing Hormone
Metod opredeleniia fragmentov peptidnykh bioreguliatorov, otvetstvennykh za vzaimodeĭstvie s retseptorom.