[The participation of met-enkephalin in the display of contractile reactions of the large intestine and ileocecal sphincter].
Blockade of H-cholinoreceptors, alpha- and beta-adrenoreceptors did not lead to disappearance of the colon and ileocecal sphincter contractile responses to i.a. administration of met-enkephalin (0.05-8.0 micrograms). The responses of the colon, as well as ileum and jejunum were augmented under blockade of alpha-adrenoreceptors whereas the responses of ileocecal sphincter decreased. The latters were augmented under blockade of beta-adrenoreceptors. Met-enkephalin infused into the vascular bed of an isolated portion of the intestine (0.01-5.0 micrograms/ml/min), potentiated the colon and ileocecal sphincter responses to acetylcholine (1.0-20.0 micrograms), the colon responses to stimulation of the n. vagus efferent fibers, and the ileocecal sphincter responses to serotonin (20-100 micrograms).
Grishina
O Iu
OIu
Ovsiannikov
V I
VI
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004744:Enkephalin, Methionine / Q000494:pharmacology / Q000502:physiology*; D007080:Ileocecal Valve / Q000187:drug effects / Q000502:physiology*; D007420:Intestine, Large / Q000187:drug effects / Q000502:physiology*; D007537:Isometric Contraction / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D012701:Serotonin; D004744:Enkephalin, Methionine; D000109:Acetylcholine
Ob uchastii met-énkefalina v proiavlenii sokratitel'nykh reaktsiĭ tolstoĭ kishki i ileotsekal'nogo sfinktera.