[Effector modeling of the action of ligands of GABA-receptor complex. Functional interaction of the hypothetic alcohol receptor with other subunits of the complex].
The types of the interaction of the pharmacological effects of ethanol and barbiturate antagonists--picrotoxin, bemegride and corasol--were determined. The effect of ethanol was determined as competitive--for the convulsant effects of bicuculline, and non-competitive--for the effects of thiosemicarbazide. The indices of the anticonvulsant effects of n-aliphatic alcohols were compared. It is suggested that n-aliphatic alcohols alter the functional status of the supramolecular GABA-receptor channel ensemble. The pharmacological properties and the elements of the structural similarity of picrotoxin and n-propanol (the presumptive ligand of the GABA-receptor channel ensemble) are discussed.
Zhuk
O V
OV
Zin'kovskiĭ
V G
VG
Golovenko
N Ia
NIa
D000433:1-Propanol / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D001463:Barbiturates / Q000037:antagonists & inhibitors*; D001534:Bemegride / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D000440:Butanols / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D000432:Methanol / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D000439:Pentanols / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012663:Semicarbazides / Q000494:pharmacology
D000433:1-Propanol; D000438:Alcohols; D001463:Barbiturates; D001534:Bemegride; D001640:Bicuculline; D000440:Butanols; D000431:Ethanol; D000432:Methanol; D000439:Pentanols; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011963:Receptors, GABA-A; D012663:Semicarbazides; C005151:thiosemicarbazide
Effektornoe modelirovanie deĭstviia ligandov GAMK-retseptornogo kompleksa. Funktsional'noe vzaimodeĭstvie gipoteticheskogo retseptora spirtov s drugimi sub"edinitsami kompleksa.