The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family.
The cloning and sequencing of the oncogene of the avian erythroblastosis virus S13 is described. The oncogene, termed v-sea, was found to be another member of the protein-tyrosine kinase gene family. The oncogene was fused in frame with the retrovirus S13 envelope gene, thus generating a fusion protein with a structure resembling that of a growth factor receptor. Sequence comparisons revealed that the v-sea gene was most closely related to the insulin receptor family of protein-tyrosine kinases, the greatest similarity being with the human MET oncogene.
Smith
D R
DR
Imperial Cancer Research Fund Laboratories, Lincolns Inn Fields, London, England.
Vogt
P K
PK
Hayman
M J
MJ
D001355:Alpharetrovirus / Q000201:enzymology / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D005347:Fibroblasts; D005796:Genes; D008969:Molecular Sequence Data; D005810:Multigene Family; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D051381:Rats; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D009856:Oncogene Proteins, Viral; C055694:env-sea oncogene protein, Avian Erythroblastosis Retrovirus; D011505:Protein-Tyrosine Kinases