Effects of indeloxazine hydrochloride on cognitive disturbance in cycloheximide-treated mice.
The effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride] on cognitive disturbance in mice subjected to cycloheximide have been examined. Indeloxazine ameliorated cycloheximide-induced amnesia in mice, indicating a facilitatory effect of this drug on cerebral functions. Piracetam, Cahopantenate, dihydroergotoxine and viloxazine did not show significant effect on the amnesia. These results suggest that indeloxazine possesses a wider pharmacological profile than piracetam, Cahopantenate, dihydroergotoxine and viloxazine in anti-amnesic activities.
Yamamoto
M
M
Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan.
Shimizu
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy*; D003513:Cycloheximide; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D009025:Morpholines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects
D000928:Antidepressive Agents; D009025:Morpholines; C020852:indeloxazine; D003513:Cycloheximide