[Experimental study of hepatic hemodynamics and hepatic oxygen consumption after hepatectomy].
This study was undertaken in order to clarify the hepatic hemodynamics and hepatic oxygen consumption in the remaining liver after 30% and 70% hepatectomy using adult mongrel dogs and moreover was investigated the improving effect of drugs (dobutamine (DOB), dopamine (DA), dibutyryl cyclic AMP (DBcAMP) and SS-094) after hepatectomy. The hepatic blood flow after hepatectomy decreased depending on the percentage of the liver resected but the hepatic blood flow per unit liver weight increased. The hepatic oxygen consumption also decreased but the hepatic oxygen consumption per unit liver weight increased, particularly after massive hepatectomy, resulting in the elevation of hepatic oxygen extraction ratio. And the uptake of lactate per unit liver weight decreased after massive hepatectomy. The administration of DOB, DA, DBcAMP and SS-094 after massive hepatectomy increased the hepatic arterial flow and portal venous flow and as a result the hepatic oxygen delivery was increased. The improvement of hepatic hemodynamics resulted in normalizing of the relation between hepatic oxygen demand and supply, and improvement of the uptake of lactate in the remaining liver. Therefore it was considered that those drugs favored the remaining hepatic hemodynamics and metabolisms after massive hepatectomy.
Asahi
K
K
Second Department of Surgery, Nagoya University School of Medicine, Japan.
Nonami
T
T
D000183:Actihaemyl / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006498:Hepatectomy; D006499:Hepatic Artery / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011169:Portal Vein / Q000187:drug effects
D007773:Lactates; D019344:Lactic Acid; D000183:Actihaemyl; D004280:Dobutamine; D003994:Bucladesine; D004298:Dopamine