Further evidence for the GABAergic influence on memory. Interaction of GABAergic transmission with angiotensin II on memory processes.
In experiments on male Wistar rats trained on active avoidance (shuttle-box) and passive avoidance (step-through) tasks, we found that (-) nipecotic acid, the inhibitor of GABA reuptake, and muscimol, a GABAA-receptor agonist, applied after training either improved or had no effect on retention, depending on the dose used. Angiotensin II (ATII) at a dose of 0.1 microgram/kg injected intracerebroventricularly (i.c.v.) after training facilitated retention. Combinations of ATII and (-) nipecotic acid or muscimol potentiated the memory effects of ATII and GABAergic drugs, respectively. Blockade of GABA receptors (GABAA) by bicuculline or picrotoxin abolished the effects of GABAergic agonists on ATII. It is suggested that GABAergic transmission participates in the consolidation and formation of memory traces and in the retention-facilitating mechanism of action of ATII.
Yonkov
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D
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Georgiev
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V
Kambourova
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T
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D009557:Nipecotic Acids / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000804:Angiotensin II; D001640:Bicuculline; D009118:Muscimol; D009557:Nipecotic Acids; D010852:Picrotoxin; D011392:Proline; D005680:gamma-Aminobutyric Acid; C030278:nipecotic acid; C010983:homoproline