[Analysis of the nature of responses of neurons of rat spinal ganglia evoked by the activation of GABA-B receptors].
The GABA application evoked fast picrotoxin-sensitive depolarization as well as slow depolarization with decreasing membrane conductivity and hyperpolarization with increasing membrane conductivity in the neurons of the rat dorsal root ganglion. The slow picrotoxin-resistant responses to GABA were initiated with phenibut. The phenibut effects were modulated by cAMP concentration and inhibited by the pertussis toxin. The reversal potential of the phenibut effects was equal to the potassium equilibrium one. The phenibut effects were reduced by increasing K+ and Ca+ extracellular concentration, and enhanced in presence of trifluoroperazine.
Abramets
I I
II
Samoĭlovich
I M
IM
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D005727:Ganglia, Spinal / Q000166:cytology* / Q000187:drug effects; D005731:Ganglionic Stimulants; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D005731:Ganglionic Stimulants; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Analiz prirody otvetov neĭronov spina'lnykh gangliev krys, vyzyvaemykh aktivatsieĭ GAMKb-retseptorov.