Strain-dependent decrease in glutamate binding to the N-methyl-D-aspartic acid receptor during aging.
Glutamate binding to the N-methyl-D-aspartic acid (NMDA) receptor decreases in two strains of aged mice. In BALB/c mice the Bmax values decline 16% by 10 months and 45% by 30 months of age when compared to 3 months. The Kd increased more by 10 months (+29%) than by 30 months (+14%). In the C57Bl strain the Bmax was unaltered by 10 months but decreased 17% by 30 months. The Kd values, however, increased 121% by 10 months and 283% by 30 months of age. These data suggest that the age-related decline in glutamate binding to the NMDA receptor may predict a strain-specific reduction in NMDA-mediated processes (e.g. long-term potentiation, postsynaptic calcium fluxes).
Peterson
C
C
Department of Psychobiology, University of California, Irvine 92717.
Cotman
C W
CW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000254:growth & development / Q000378:metabolism*; D008810:Mice, Inbred C57BL / Q000254:growth & development / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013045:Species Specificity
D005971:Glutamates; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid