Epidemic hemorrhagic fever with renal syndrome in Yugoslavia, 1986.
An epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia May-November 1986; all Republics and Provinces were involved. Serum samples were received from 260 of 276 persons with symptoms clinically compatible with a diagnosis of HFRS. Presumptive infection with a hantavirus was determined serologically for 161 of these. Many patients with serious clinical pictures, including severe renal insufficiency and shock, were hospitalized; 11 died. Indirect fluorescent antibody tests with antigens of 4 hantaviruses (Hantaan, Fojnica, Puumala, and the Vranica strain of Puumala virus) showed that greater than 1 serotype was circulating during this epidemic. Hantavirus antigens were detected in the lungs of 86 of 302 (28.5%) wild-caught small mammals.
Gligić
A
A
Institute of Immunobiology and Virology Torlak, Belgrade, Yugoslavia.
Obradović
M
M
Stojanović
R
R
Vujosević
N
N
Ovcarić
A
A
Frusic
M
M
Gibbs
C J
CJ
Calisher
C H
CH
Gajdusek
D C
DC
D004196:Disease Outbreaks; D006476:Orthohantavirus / Q000276:immunology / Q000302:isolation & purification; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology* / Q000401:mortality; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D013997:Time Factors; D015022:Yugoslavia
D007074:Immunoglobulin G; D007075:Immunoglobulin M