title: Effects of UK 69 578: a novel atriopeptidase inhibitor.
abstract: UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.
authors.affiliation: Department of Cardiology, Western Infirmary, Glasgow.
authors.forename: D B
authors.initials: DB
authors.lastname: Northridge
authors.forename: A G
authors.initials: AG
authors.lastname: Jardine
authors.forename: C T
authors.initials: CT
authors.lastname: Alabaster
authors.forename: P L
authors.initials: PL
authors.lastname: Barclay
authors.forename: J M
authors.initials: JM
authors.lastname: Connell
authors.forename: H J
authors.initials: HJ
authors.lastname: Dargie
authors.forename: S G
authors.initials: SG
authors.lastname: Dilly
authors.forename: I N
authors.initials: IN
authors.lastname: Findlay
authors.forename: A F
authors.initials: AF
authors.lastname: Lever
authors.forename: G M
authors.initials: GM
authors.lastname: Samuels
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000037:antagonists & inhibitors* / Q000097:blood; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D003509:Cyclohexanecarboxylic Acids; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D009392:Nephrectomy; D015260:Neprilysin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D003509:Cyclohexanecarboxylic Acids; C060942:candoxatrilat; D009320:Atrial Natriuretic Factor; D015260:Neprilysin