The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).
Peters
G J
GJ
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
Laurensse
E
E
de Kant
E
E
Nadal
J C
JC
Pinedo
H M
HM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000201:enzymology; D004081:Dihydroorotate Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism*; D011742:Pyrimidine Nucleotides / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology*; D011798:Quinaldines
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D004081:Dihydroorotate Oxidase; D010088:Oxidoreductases; D011742:Pyrimidine Nucleotides; C046943:brequinar; D011798:Quinaldines