Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis.
A case of therapy-related myelodysplasia followed by acute nonlymphocytic leukemia in a 5-year-old child successfully treated for diffuse Langerhans cell histiocytosis is described. A syndrome of severe cell-mediated immune deficiency and persistent Epstein-Barr virus (EBV) infection coincided with the evolution of myelodysplasia. Specific abnormalities of chromosomes number 7 and 3 were associated with the onset of myelodysplasia and acute nonlymphocytic leukemia and are believed to be linked to the patient's immune dysfunction and compromised ability to contain viral infection.
Mahoney
D H
DH
Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston 77030.
McClain
K L
KL
Hanson
I C
IC
Taylor
L D
LD
Steuber
C P
CP
D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure*; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology; D004854:Herpesvirus 4, Human; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000235:genetics; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000150:complications / Q000235:genetics; D009190:Myelodysplastic Syndromes / Q000139:chemically induced* / Q000150:complications / Q000235:genetics; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy*
D002699:Chlorambucil