[The in vitro effect of silica fibers on macrophage-mediated cytotoxic activities in mice].
The in vitro effects of silica fibers on macrophage-mediated cytotoxic activities in mice were studied, including 1) macrophage-mediated tumor cytolysis (MTC), 2) macrophage-mediated tumor cytostasis (MTCS) and 3) antibody-dependent cell-mediated cytolysis (ADCC), we found that silica fibers markedly inhibited both MTC and ADCC but slightly promoted MTCS. Silica fibers were active during the activation phase mediated by macrophage-activating factor as well as in the effector phases of MTC and MTCS. In ADCC, increasing the antibody titer could not abrogate the inhibitory effect of silica fibers.
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D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012822:Silicon Dioxide / Q000494:pharmacology*
D012822:Silicon Dioxide