Analysis of hemodynamics and blood gas in relation to blood ketone body ratio in partially hepatectomized patients.
A total of 205 studies of hemodynamics and blood gas analyses were performed in relation to hepatic mitochondrial redox state in 23 partially hepatectomized patients. When the blood ketone body ratio (the ratio of acetoacetate to beta-hydroxybutyrate in arterial blood) decreased, that is when the hepatic mitochondrial redox state was reduced, a hyperdynamic state with increased cardiac index, decreased systemic and pulmonary vascular resistance together with decreased oxygen consumption was observed in spite of the increased oxygen availability. Inhibited oxidative metabolism in the Krebs cycle may have resulted in the decreased oxygen consumption and decreased vascular tone. This study supports the concept that the hepatic metabolic derangements due to reduced hepatic mitochondrial redox state may be a factor in the decreased oxygen consumption and hyperdynamic state.
Nakatani
T
T
Trauma and Critical Care Center, Teikyo University School of Medicine, Tokyo, Japan.
Shimahara
Y
Y
Mori
K
K
Kobayashi
N
N
Yamaoka
Y
Y
Kobayashi
K
K
Ozawa
K
K
D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D005260:Female; D006439:Hemodynamics; D006498:Hepatectomy; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D008113:Liver Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction
D007657:Ketone Bodies