Ethanol suppresses hippocampal cell firing through a calcium and cyclic AMP-sensitive mechanism.
The effects of ethanol were studied intracellularly in hippocampal pyramidal cells in vitro. Ethanol, 50-100 mM, produced a marked suppression of neuronal firing. This effect was blocked by treating the cell with cyclic 3', 5'-adenosine monophosphate (cAMP) or cadmium ions. Ethanol had no effect on the after-hyperpolarizing current. It is concluded that the ethanol-induced reduction of firing rate is due to a calcium-dependent process, and modulated by cAMP.
Benson
D M
DM
Department of Psychiatry, Bronx VA Medical Center, NY 10468.
Blitzer
R D
RD
Landau
E M
EM
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D008566:Membranes / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology
D015124:8-Bromo Cyclic Adenosine Monophosphate; D000431:Ethanol; D011189:Potassium Chloride; D000242:Cyclic AMP; D002118:Calcium