Gangliosides enhance behavioral and neurochemical effects induced by chronic desipramine (DMI) treatment.
Rats pretreated with gangliosides showed a significant enhancement of the anti-immobility effect of desipramine (DMI) in the forced swimming test. Accordingly, an associated treatment of gangliosides and DMI for 7 days significantly enhanced beta-adrenergic down-regulation in the frontal cortex as compared with the effect of DMI alone. Gangliosides exerted an accelerating effect on the decrease of beta-adrenoceptor density induced by DMI, since the down-regulation phenomenon appeared after 3 days of treatment. Gangliosides did not affect the pharmacokinetics of DMI, since associated acute or prolonged treatments did not modify the brain levels of DMI as compared to the levels of animals that had received DMI alone. These results evidence a stimulating effect of gangliosides on the development of adaptative receptor changes induced by chronic DMI treatment.
Molina
V A
VA
Departamento de Farmacología, Universidad Nacional de Córdoba, Argentina.
Keller
E A
EA
Orsingher
O A
OA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D003891:Desipramine / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D005732:Gangliosides / Q000494:pharmacology*; D006380:Helplessness, Learned; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D005732:Gangliosides; D011943:Receptors, Adrenergic, beta; D003891:Desipramine