Studies on inhibitors of skin tumor promotion, VI. Inhibitory effects of quinones on Epstein-Barr virus activation.
To search for possible antitumor promoters, we carried out a primary screening of fifty-one quinones (anthraquinones, naphthoquinones, azaanthraquinones, and azafluorenones) and related compounds, using their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these quinones, notably 5-hydroxy-1,2-methylenedioxy-anthraquinone [9], shikonin [29], 2-acetylfuranonaphthoquinone [32], 5,8-dihydroxycleistopholine [37], and 5,8-dihydroxy-2-methyl-1-azaanthraquinone [45], were observed to significantly inhibit the EBV-EA activation at low doses. The position and number of hydroxyl groups on phenyl rings of these quinones affected the inhibitory activity on EBV-EA activation. The investigation indicates that 9, 29, 32, 37, and 45 might be valuable anti-tumor promoters.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Kozuka
M
M
Koyama
J
J
Okatani
T
T
Tagahara
K
K
Tokuda
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D011809:Quinones / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects*
D000972:Antineoplastic Agents, Phytogenic; D011809:Quinones; D013755:Tetradecanoylphorbol Acetate