[Action of the leukotriene LTC4 on the calcium channels of the somatic membrane of the nerve cell and tone of smooth muscle organs].
Effects of synthetic leukotriene LTC4 on the internally perfused voltage-clamped snail neurons as well as on the electrical and mechanical activities of the stomach smooth muscle cells were studied. It was found that LTC4 increased calcium inward current in the soma membrane of a cell by activation of both voltage and receptor operated Ca-channels. LTC4 was effective only from outside but not from inside of the membrane which indicated that there was a receptor for leukotrienes in the neuronal membrane.
Skryma
R N
RN
Kalashnikova
L E
LE
Degtiar'
V E
VE
Prevarskaia
N B
NB
Burdyga
F V
FV
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D006168:Guinea Pigs; D006372:Helix, Snails / Q000502:physiology; D009129:Muscle Tonus; D009130:Muscle, Smooth / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013189:SRS-A / Q000502:physiology*; D013270:Stomach / Q000502:physiology; D014513:Ureter / Q000502:physiology
D015220:Calcium Channels; D013189:SRS-A
Deĭstvie leĭkotriena LTC4 na kal'tsievye kanaly somaticheskoĭ membrany nervnoĭ kletki i tonus gladkomyshechnykh organov.