Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti.
The amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase (17 beta-OH-steroid dehydrogenase) was found to be similar to that of the NodG protein of Rhizobium meliloti. The computer-based comparison score is 11.5 SD higher than that obtained with 2500 comparisons of randomized sequences of these proteins. The probability of getting such a score by chance is 6 x 10(-31). 17 beta-OH-steroid dehydrogenase is also similar to Klebsiella aerogenes ribitol dehydrogenase and Escherichia coli glucitol-6-phosphate dehydrogenase. We propose that the steroid recognition site on 17 beta-OH-steroid dehydrogenase evolved from an ancestral recognition site for polyols such as ribitol and glucitol-6-phosphate.
Baker
M E
ME
Department of Medicine, University of California, San Diego, La Jolla 92093.
D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics*; D000429:Alcohol Oxidoreductases; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005419:Flavonoids; D006801:Humans; D047311:Luteolin; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D012231:Rhizobium / Q000235:genetics*
D001426:Bacterial Proteins; D005419:Flavonoids; C060531:NodG protein, Rhizobium meliloti; D004958:Estradiol; D015067:17-Hydroxysteroid Dehydrogenases; D000429:Alcohol Oxidoreductases; C032690:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); D047311:Luteolin