title: Behaviour of spherical and irregular (U,Pu)O2 particles after inhalation or intratracheal instillation in rat lung and during in vitro culture with bovine alveolar macrophages.
abstract: Spherical and irregularly shaped mixed (U,Pu) oxide particles were administered to rats by inhalation and by intratracheal instillation. The lung retention of the particles was independent of particle shape and of the route of administration. Only a small percentage of the administered radioactivity was found in other organs. Detailed electron microscopic studies showed particles within membrane-enclosed vacuoles as well as lying free in the cytoplasm.
authors.affiliation: Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, F. R. Germany.
authors.forename: H L
authors.initials: HL
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Drosselmeyer
authors.forename: G
authors.initials: G
authors.lastname: Hotz
authors.forename: A
authors.initials: A
authors.lastname: Seidel
authors.forename: H
authors.initials: H
authors.lastname: Thiele
authors.forename: S
authors.initials: S
authors.lastname: Pickering
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002417:Cattle; D005260:Female; D007322:Instillation, Drug; D008168:Lung / Q000648:ultrastructure; D008264:Macrophages; D008854:Microscopy, Electron; D011005:Plutonium / Q000008:administration & dosage*; D011650:Pulmonary Alveoli / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea; D014501:Uranium / Q000008:administration & dosage*; D017974:Uranium Compounds
chemical_list: D017974:Uranium Compounds; C026885:plutonium dioxide; D014501:Uranium; D011005:Plutonium; C012597:uranium dioxide