[In vivo imaging of Hodgkin's lymphomas using monoclonal antibodies].
The Hodgkin- and Reed-Sternberg cell associated monoclonal antibody HRS-1 was labeled with radioactive iodine and injected into 6 patients with Hodgkin's lymphoma for immunoscintigraphic imaging. Four of five patients who received 131I-labeled HRS-1 had a positive immunoscintigram. In the sixth patient, the HRS-1 Mab was labeled with 123I in order to utilize tomoscintigraphy instead of linear scintigraphy. Bony disease was demonstrated by immunoscintigraphy in this patient. These preliminary results demonstrate that immunoscintigraphy with iodine-labeled HRS-1 Mab is feasible and informative in Hodgkin's lymphoma. The real clinical value of immunoscintigraphy in Hodgkin's lymphoma must be determined in a larger series of patients. Several modifications of the technique such as the use of Fab or F(ab')2 fragments should further improve the results.
Pfreundschuh
M
M
Medizinische Klinik I, Universität Köln.
Carde
P
P
Da Costa
L
L
Manil
L
L
Lumbroso
J D
JD
Caillou
B
B
Boudet
F
F
Ricard
M
M
Hayat
M
M
Diehl
V
V
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000943:Antigens, Differentiation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D017730:Ki-1 Antigen; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging; D008875:Middle Aged; D011877:Radionuclide Imaging; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D007457:Iodine Radioisotopes; D017730:Ki-1 Antigen
In-vivo-Imaging von Hodgkin-Lymphomen mit monoklonalen Antikörpern.