title: Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.
abstract: The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.
authors.affiliation: Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Wilkinson
authors.forename: S
authors.initials: S
authors.lastname: Bhatt
authors.forename: M
authors.initials: M
authors.lastname: Cook
authors.forename: E
authors.initials: E
authors.lastname: Boncinelli
authors.forename: R
authors.initials: R
authors.lastname: Krumlauf
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development; D015870:Gene Expression; D005801:Genes, Homeobox; D051379:Mice; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012249:Rhombencephalon / Q000196:embryology*; D014158:Transcription, Genetic