Complement-independent neutralising monoclonal antibody with differential reactivity for strains of human cytomegalovirus.
A mouse monoclonal antibody with complement-independent neutralising activity against cytomegalovirus (CMV) and reactive with the 86 kilodalton (kDa) viral glycoprotein H is described. Neutralisation tests against a range of different strains of CMV showed significant crossreactivity, but clear differences were evident between the two prototype viruses AD169 and Davis, and particularly between AD169 and several low-passage recent clinical isolates; CMV present in urine was neutralised weakly if at all.
Baboonian
C
C
Department of Medical Microbiology, St. George's Hospital Medical School, University of London, England.
Blake
K
K
Booth
J C
JC
Wiblin
C N
CN
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D000918:Antibody Specificity; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D011233:Precipitin Tests; D013045:Species Specificity
D000911:Antibodies, Monoclonal