Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles.
The vasoactive properties of inhibitory (gamma-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10(-9) and 10(-3) M, except for 10(-3) M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.
Takayasu
M
M
Division of Neurological Surgery, University of North Carolina, Chapel Hill 27599-7060.
Dacey
R G
RG
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects*; D066298:In Vitro Techniques; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000596:Amino Acids; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid