Severe neuropathy in a patient with acquired immune deficiency syndrome (AIDS). Evidence for widespread cytomegalovirus infection of peripheral nerve and human immunodeficiency virus-like immunoreactivity of anterior horn cells.
A patient with acquired immune deficiency syndrome (AIDS) developed a progressive neuromuscular disorder which included a sensory component, severe weakness and muscle wasting, and fasciculations. At autopsy, there was evidence of severe peripheral neuropathy, as well as widespread cytomegalovirus (CMV) infection within the central and peripheral nervous system. Although the anterior horn cell complement within the spinal cord appeared normal, there was also evidence of human immunodeficiency virus (HIV)-like immunoreactivity of rare anterior horn cells, as judged by immunohistochemical staining. This patient illustrates the complexity of pathogenetic mechanisms operative in AIDS patients with neuromuscular disease, and suggests that at least some examples of neuromuscular disease in patients with this syndrome may be related to widespread CMV infection of the peripheral nerve (including microvascular endothelial cells) and, more rarely, direct HIV infection of some anterior horn cells.
Robert
M E
ME
Department of Pathology, UCLA Medical Center 90024-1732.
Geraghty
J J
JJ
Miles
S A
SA
Cornford
M E
ME
Vinters
H V
HV
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology*; D000328:Adult; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000473:pathology*; D006678:HIV / Q000276:immunology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*