title: Formation of long-term potentiation in superior colliculus slices from the guinea pig.
abstract: Superior colliculus slices of sagittal section were prepared from the guinea pig. Postsynaptic potential (PSP) was evoked in the superficial grey layer (SGL) after the electrical stimulation to optic layer. Tetanic stimulation to the optic layer elicited long-term potentiation (LTP) in the PSP of the SGL. Tetanic stimulation of 20 s in duration and 50 Hz in frequency was most effective for the formation of LTP. The LTP formation was masked during application of 2-amino-5-phosphonovalerate (APV), a specific antagonist for N-methyl-D-aspartate (NMDA) receptor, but LTP was observed when APV was removed from the perfusion medium.
authors.affiliation: Department of Physiology, School of Medicine, Kobe University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
mesh_terms: D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D014633:Valine