title: [Changes in the intermediate filament cytoskeleton of liver cells in alcoholic liver injury].
abstract: Mallory bodies are a morphological key feature of severe alcoholic liver cell injury (alcoholic hepatitis) and the morphological expression of dysregulation and derangement of the intermediate filament cytoskeleton of the hepatocyte. Their pathogenesis is still unclear. Studies on Mallory body formation may not only help to elucidate the mechanisms of liver cell injury associated with alcoholic hepatitis, but may also contribute to our understanding of the regulation and function of the intermediate filament cytoskeleton.
authors.forename: H
authors.initials: H
authors.lastname: Denk
authors.forename: E
authors.initials: E
authors.lastname: Lackinger
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003078:Colchicine / Q000502:physiology; D003599:Cytoskeleton / Q000032:analysis / Q000648:ultrastructure*; D004591:Electrophoresis, Polyacrylamide Gel; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006118:Griseofulvin / Q000633:toxicity; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007525:Isoelectric Focusing; D007633:Keratins / Q000032:analysis / Q000276:immunology; D008099:Liver / Q000648:ultrastructure*; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology*; D051379:Mice; D008854:Microscopy, Electron; D051381:Rats
chemical_list: D007518:Isoantibodies; D006118:Griseofulvin; D007633:Keratins; D003078:Colchicine
vernacular_title: Veränderungen des Intermediärfilament-Zytoskeletts der Leberzelle beim alkoholischen Leberschaden.