Mapping cell surface antigens on mouse pre-B cell lines.
Characterization of cell surface molecules expressed by B cell precursors has been hampered by the inability to routinely assay such cells from freshly explanted normal lymphoid tissues. However, a large number of transformed pre-B cell clones have been isolated which presumably include those precursors recently entering the B cell lineage (obtained from fetal liver and more rarely from adult bone marrow) and extending to those clones which are poised to become surface Ig-positive B cells. In this report, we have quantitated expression of 10 different cell surface molecules, 5 of which bear special interest as B cell differentiation antigens, among a large panel of pre-B cell clones.
McKearn
J P
JP
Rosenberg
N
N
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000166:cytology*; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells / Q000166:cytology; D000939:Epitopes / Q000032:analysis*; D005333:Fetus; D008099:Liver / Q000196:embryology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D000954:Antigens, Surface; D000939:Epitopes