[Inhibition of thromboxane production might ameliorate liver blood flow in shock].
We investigated whether thromboxane (TX), a vasoconstrictor, contributes to liver disturbance in shock by reducing liver blood flow.


METHODS
experimental groups: Sham, Et: endotoxin 4mg/kg, BDL + Et: bile duct ligation with Et, OKY. BDL + BDL + Et with infusion of OKYO46 (TX synthetase inhibitor) 5mg, HT: three days after 70% hepatectomy, OKY. HT: HT receiving OKYO46. We evaluated prostanoid and morbidity in hepatectomized cases.


METHODS
TX, liver phospholipid, liver blood flow, endotoxin.


RESULTS
Higher TX levels in blood and liver, and reduced liver phospholipid and liver blood flow in BDL + Et returned close to sham by OKYO46. High blood endotoxin in HT decreased by OKYO46. Intraoperative blood losses in cases with postoperative intraabdominal infection or hepatic failure were greater than those without complication. Hepatectomized cases with intraabdominal infection showed higher blood TX than those without complication. TX might be associated with decreased liver blood flow and with postoperative complication during shock. To reduce TX production would be beneficial in shock by ameliorating liver blood flow.
Hanai
T
T
First Department of Surgery, Nagoya City University Medical School, Japan.
Yura
J
J
Ogino
K
K
Hori
K
K
Tanaka
M
M
Mizuno
A
A
Shinagawa
N
N
D000818:Animals; D004731:Endotoxins / Q000097:blood; D006498:Hepatectomy; D008102:Liver Circulation; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000503:physiopathology*; D013931:Thromboxanes / Q000096:biosynthesis*
D004731:Endotoxins; D010743:Phospholipids; D013931:Thromboxanes