Effect of pirenzepine on aminopyrine uptake by isolated guinea pig parietal cells.
The inhibitory action of pirenzepine on acid secretion of isolated guinea pig parietal cells was investigated by the aminopyrine method. Pirenzepine markedly inhibited acid secretion of isolated parietal cells induced by carbachol in a dose-dependent manner but showed no inhibition on acid secretion stimulated by histamine. These results may suggest a direct action of pirenzepine on muscarinic receptors in parietal cells.
Tani
N
N
Dept. of Internal Medicine, School of Medicine, Tokai University, Kanagawa Prefecture, Japan.
Watanabe
Y
Y
Mutoh
N
N
Karasawa
H
H
Hara
M
M
Miwa
T
T
D000632:Aminopyrine / Q000493:pharmacokinetics*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D010295:Parietal Cells, Gastric / Q000187:drug effects*; D010890:Pirenzepine / Q000008:administration & dosage / Q000494:pharmacology*
D000632:Aminopyrine; D010890:Pirenzepine; D001285:Atropine