The effect of phentolamine on basal and pethidine-induced inhibition of gastric emptying in healthy volunteers.
1. The effect of phentolamine 5 mg i.v. on basal and pethidine-induced inhibition of gastric emptying of semisolid TC-99m labelled Chelex-100 resin/oatmeal was studied in ten healthy volunteers. 2. Each volunteer acted as his/her own control. 3. Basal gastric emptying remained unchanged after administration of phentolamine. 4. Administration of phentolamine reversed the pethidine-induced inhibition of gastric emptying.
Petring
O U
OU
Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*
D008614:Meperidine; D010646:Phentolamine