title: Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock.
abstract: Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.
authors.affiliation: S.E. Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
authors.forename: G R
authors.initials: GR
authors.lastname: Barclay
authors.forename: B B
authors.initials: BB
authors.lastname: Scott
authors.forename: I H
authors.initials: IH
authors.lastname: Wright
authors.forename: P N
authors.initials: PN
authors.lastname: Rogers
authors.forename: D G
authors.initials: DG
authors.lastname: Smith
authors.forename: I R
authors.initials: IR
authors.lastname: Poxton
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000032:analysis*; D004731:Endotoxins / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology* / Q000502:physiology; D008070:Lipopolysaccharides / Q000097:blood / Q000276:immunology*; D008297:Male; D011008:Pneumococcal Infections / Q000097:blood / Q000276:immunology / Q000628:therapy; D012772:Shock, Septic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004731:Endotoxins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C042058:core endotoxin