title: Host genetic regulation of acute MHV-4 viral encephalomyelitis and acute experimental autoimmune encephalomyelitis in (BALB/cKe x SJL/J) recombinant-inbred mice.
abstract: In the present report we provide the strain distribution patterns of susceptibility to acute mouse hepatitis virus type-4 (MHV-4) encephalomyelitis, acute experimental allergic encephalomyelitis (EAE) and vasoactive amine sensitivity (VAAS) for 9 (CXJ) recombinant-inbred strains between BALB/cKe (C) and SJL/J(J) mice. We confirm that susceptibility to MHV-4 is not linked to the H-2 complex, and that all strains susceptible to acute EAE have both a responder H-2 haplotype (H-2s or H-2d) and induced (B. pertussis) VAAS. In addition, we provide evidence that susceptibility to acute EAE induction is controlled by an additional presently unmapped locus and that an EAE-like histopathological disease does not usually follow MHV-4 infection intracerebrally in animals susceptible to MHV-4, acute EAE and induced VAAS.
authors.forename: R L
authors.initials: RL
authors.lastname: Knobler
authors.forename: D S
authors.initials: DS
authors.lastname: Linthicum
authors.forename: M
authors.initials: M
authors.lastname: Cohn
mesh_terms: D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology; D004679:Encephalomyelitis / Q000235:genetics* / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006238:Haploidy; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000276:immunology; D006632:Histamine / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats
chemical_list: D006183:H-2 Antigens; D004676:Myelin Basic Protein; D006632:Histamine