[Functional status of the endocrine system in patients with hypertrophic cardiomyopathy].
The study was undertaken to examine 27 patients aged 20 to 50 years who had hypertrophic cardiomyopathy (HC). Group 1 consisted of 12 patients with asymmetric cardiomyopathy. Group 2 comprised 15 with symmetric cardiomyopathy. Blood samples were taken from the cubital vein before and 30 and 60 minutes after administration of 0.2 mg thyroid-releasing hormone (TRH). Blood hormone concentrations were measured by radioimmunoassay. TRH test was found to provide an essential information on the function of the hypothalamo-hypophyseal-thyroid and hypothalamohypophyseal-adrenal systems in HC patients. The HC patients showed lower function of the hypothalamo-hypophyseal-adrenal system. There was a decrease in serum testosterone during all the periods of examination. At the same time the patients from Groups 1 and 2 had substantial features of the function of various links of the immune system, which may suggest a variance in the pathogenesis of the two types of the disease.
Iakovlev
G M
GM
Medvedev
V M
VM
Iakovlev
V A
VA
Kulagin
K V
KV
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000097:blood / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*
D006728:Hormones
Funktsiona'lnoe sostoianie éndokrinnoĭ sistemy u bo'lnykh s gipertroficheskoĭ kardiomiopatieĭ.