[The metabolic pathways of concanavalin A action on the chemosensitivity of the neuronal membrane].
It has been shown that concanavaline A (Co A) inhibited those acetylcholine (ACh) and gamma-aminobutyric acid (GABA) responses of the membrane of dialyzed snail neurons which were blocked by ouabain. The inhibitory effect of Co A on these responses was removed at 5 degrees C. Co A had no significant influence on ACh responses which were insensitive to ouabain. Co A inhibited ACh-induced 86Rb+ ions efflux from the neurons preliminarily enriched by these ions. Co A has exerted a stimulating effect on the phosphorylation of neuronal membrane fractions. In this case Co A decreased the intracellular cyclic adenozine monophosphate (cAMP) content and increased the intracellular content of cyclic guanozine monophosphate. It is supposed that cAMP-independent membrane phosphorylation underlies the Co A inhibiting effect on the neuronal membrane sensitivity to ACh and GABA.
Arvanov
V L
VL
Azatian
K V
KV
Aĭrapetian
S N
SN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology*; D004347:Drug Interactions; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D010766:Phosphorylation; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism; D012414:Rubidium Radioisotopes; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D009712:Nucleotides, Cyclic; D011950:Receptors, Cholinergic; D012414:Rubidium Radioisotopes; D003208:Concanavalin A; D005680:gamma-Aminobutyric Acid; D010042:Ouabain; D000109:Acetylcholine
Metabolicheskie puti vozdeĭstviia konkanavalina A na khemochuvstvitel'nost' membrany neĭronov.