[A comparative study of the effectiveness of regulatory peptides in acute experimental pancreatitis].
The effect of regulatory peptides on the functional activity of pancreatic cells and phagocytic cells of reticuloendothelial system were determined in intact dogs against the background of acute experimental pancreatitis. Assessment of the efficacy of regulatory peptides was made with the aid of scintigraphic studies in gamma chamber using for this purpose colloid 198Au and 75Se-methionine. It was established that introduction of regulatory peptides to dogs leads to inhibition of capture of labeled methionine by pancreatocytes, practically not influencing the elimination of colloid gold from circulation.
Grigorevskiĭ
V P
VP
Pashutin
S B
SB
Satrapinskiĭ
V Iu
VIu
Gordeev
V F
VF
Priĭmak
S A
SA
Shatalov
V N
VN
Vinogradov
V A
VA
D000208:Acute Disease; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010587:Phagocytosis / Q000187:drug effects; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000494:pharmacology / Q000627:therapeutic use*; D013565:Sympatholytics / Q000494:pharmacology / Q000627:therapeutic use*
D013565:Sympatholytics; D013004:Somatostatin; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D002116:Calcitonin; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Sravnitel'naia otsenka éffektivnosti reguliatornykh peptidov pri ostrom éksperimental'nom pankreatite.