title: Cytogenetic and clinical investigations in 76 cases with therapy-related leukemia and myelodysplastic syndrome.
abstract: Clinical, cytomorphologic, and cytogenetic investigations were carried out in a series of 76 secondary MDS and ANLL. Chromosome abnormalities were more frequent in patients with a history of multiple myeloma or macroglobulinemia (92%) and myeloproliferative disorders (82%) than in patients with previous breast cancer (40%). The secondary hematologic malignancies were mostly a trilineage bone marrow disorder. The most commonly found cytogenetic anomaly was monosomy 7, followed by total or partial loss of chromosome 5. In addition six other chromosomes, i.e., chromosome 3, 8, 9, 12, 17, and 21 seemed to be consistently involved in the pathogenetic mechanisms of secondary leukemia and MDS.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Iurlo
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: A
authors.initials: A
authors.lastname: Van Orshoven
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: M
authors.initials: M
authors.lastname: Boogaerts
authors.forename: L
authors.initials: L
authors.lastname: Noens
authors.forename: A
authors.initials: A
authors.lastname: Bosly
authors.forename: A
authors.initials: A
authors.lastname: Louwagie
authors.forename: H
authors.initials: H
authors.lastname: Van Den Berghe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*