title: The major histocompatibility complex and insulin dependent (type 1) diabetes.
abstract: The majority of the genetic component in insulin dependent (Type 1) diabetes mellitus can be explained by associations with genes on short arm of chromosome 6 located in the major histocompatibility complex. With the advent of cloning of the HLA Class II region genes it has been possible to refine the previous known association of HLA-DR3 and DR4 with this disease. Strong associations of IDDM have now been shown to exist with the DQB1 gene and/or linked genes, although this does not completely explain the HLA susceptibility to this disease.
authors.affiliation: Medical Unit, London Hospital, Whitechapel.
authors.forename: G A
authors.initials: GA
authors.lastname: Hitman
mesh_terms: D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D004247:DNA