title: [Somatostatin in the emergency treatment of upper digestive hemorrhage in patients with portal hypertension].
abstract: During a 2-yr period 15 patients (17 episodes) with variceal bleeding (VB) and 7 with cirrhosis and acute gastroduodenal haemorrhage (GDH) received intravenous somatostatin (250 mcg per hr after a bolus of 250 mcg). Initial control of bleeding was achieved in 13 (76%) with VB and in all with GDH. Three of the 4 patients with VB and 2 with GDH who rebled during treatment were controlled increasing the infusion to 500 mcg/hr. Patients with VB received somatostatin for 24 hrs, time selected for initiating injection sclerotherapy, and those with GDH for 48-72 hrs. At 24 hrs 71% of patients with VB and all with GDH were free of bleeding. Combining different therapies VB was controlled in 16 of the 17 episodes (94%) with only one death. No complications were observed in any of the 22 patients treated.
authors.affiliation: Hospital Italiano de Buenos Aires, Terapia Intensiva y Gastroenterología.
authors.forename: F G
authors.initials: FG
authors.lastname: Villamil
authors.forename: M
authors.initials: M
authors.lastname: Perman
authors.forename: A
authors.initials: A
authors.lastname: Gallesio
authors.forename: M
authors.initials: M
authors.lastname: Butera
authors.forename: L
authors.initials: L
authors.lastname: Soifer
authors.forename: H
authors.initials: H
authors.lastname: Aziz
authors.forename: E
authors.initials: E
authors.lastname: San Román
mesh_terms: D000328:Adult; D000368:Aged; D004630:Emergencies; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D013004:Somatostatin / Q000627:therapeutic use*
chemical_list: D012597:Sclerosing Solutions; D013004:Somatostatin
vernacular_title: Somatostatina en el tratamiento de emergencia de la hemorragia digestiva alta en hipertensos portales.