title: The determination of fenspiride in human plasma and urine by liquid chromatography with electrochemical or ultraviolet detection.
abstract: A selective and sensitive method for the determination of fenspiride in biological fluids is described. The method involves liquid-liquid extraction followed by separation on a reversed-phase column with electrochemical detection for low levels of the drug in plasma (less than or equal to 100 ng ml-1) or UV absorption for higher concentrations in plasma or urine. The method is suitable for pharmacokinetic analyses and drug monitoring studies.
authors.affiliation: Bio-Pharmacie Servier, Orléans, France.
authors.forename: C
authors.initials: C
authors.lastname: Sauveur
authors.forename: A
authors.initials: A
authors.lastname: Baune
authors.forename: N
authors.initials: N
authors.lastname: Vergnes
authors.forename: J P
authors.initials: JP
authors.lastname: Jeanniot
mesh_terms: D002853:Chromatography, Liquid; D004563:Electrochemistry; D006801:Humans; D007202:Indicators and Reagents; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D007202:Indicators and Reagents; D013141:Spiro Compounds