Effect of nomifensine on platelet monoamine oxidase activity in chronic schizophrenic patients.
1. The levels of platelet MAO activity increase and the frequency of affective symptoms diminish in the depressed chronic schizophrenics treated with nomifensine. 2. Nomifensine has no inhibitory effect in vitro on platelet MAO activity in depressed schizophrenic pellets.
Filinger
E J
EJ
Facultad de Farmacia y Bioquímica (UBA), Instituto de Investigaciones Farmacológicas (CONICET), Buenos Aires, Argentina.
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D001798:Blood Proteins / Q000378:metabolism; D003866:Depressive Disorder / Q000201:enzymology / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D009627:Nomifensine / Q000009:adverse effects* / Q000627:therapeutic use; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000201:enzymology*
D001798:Blood Proteins; D009627:Nomifensine; D008995:Monoamine Oxidase