The role of calcium ion in methoxamine-induced amylase release from parotid glands of euthyroid and hypothyroid rats.
The change in responsiveness to alpha-adrenergic stimulation and to calcium ions in amylase release from parotid glands of hypothyroid rats was compared with that in euthyroid rats. Calcium depletion and addition of verapamil or W-7 in the medium caused a decrease in methoxamine-induced amylase release in both eu- and hypothyroid rats. Moreover, addition of calcium ions to Ca2+-free medium markedly increased the methoxamine-induced amylase release in proportion to its concentration in hypothyroid rats. These results suggest that calcium ions play an important role in methoxamine-induced amylase release from parotid glands of hypothyroid rats as well as those of the euthyroid ones.
Hagino
Y
Y
Nomura
H
H
Nomura
T
T
Maekawa
H
H
Izuhara
K
K
Tachibana
M
M
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D007037:Hypothyroidism / Q000201:enzymology; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D010306:Parotid Gland / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013449:Sulfonamides / Q000494:pharmacology; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D014700:Verapamil / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D002147:Calmodulin; D013449:Sulfonamides; C017967:W 7; D014700:Verapamil; D000681:Amylases; D008729:Methoxamine; D002118:Calcium