title: Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.
abstract: The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective remission was observed within 3 months and salazosulfapyridine was withdrawn after a further 6 months of therapy. At 6 years of age clinical and radiological recurrence of gastric obstruction was observed. Salazosulfapyridine was reinstated and continued as maintenance therapy. The child has been well for more than 4 years. Salazosulfapyridine therapy can be recommended as safe conservative treatment of gastric obstruction in CGD.
authors.affiliation: Second Department of Paediatrics, Institute of Paediatrics, Copernicus Medical School, Cracow, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Stopyrowa
authors.forename: K
authors.initials: K
authors.lastname: Fyderek
authors.forename: B
authors.initials: B
authors.lastname: Sikorska
authors.forename: D
authors.initials: D
authors.lastname: Kowalczyk
authors.forename: M
authors.initials: M
authors.lastname: Zembala
mesh_terms: D002648:Child; D004338:Drug Combinations / Q000627:therapeutic use; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D008297:Male; D011859:Radiography; D013277:Stomach Volvulus / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D012460:Sulfasalazine / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C028423:Salazopyrine; D012460:Sulfasalazine; D005944:Glucosamine