Ascending myelopathy after chemotherapy for central nervous system acute lymphoblastic leukemia: correlation with cerebrospinal fluid myelin basic protein.
Ascending myelopathy developed in a previously irradiated 10-year-old boy after intraventricular methotrexate and cytosine arabinoside were given for central nervous system relapse of acute lymphoblastic leukemia. The course was fatal in 10 weeks. Cerebrospinal fluid myelin basic protein levels, indicating a demyelinative process, rose prior to the onset of clinical symptoms and remained at very high levels until death. Myelin basic protein may be useful as a predictor of chemotherapy-associated neurotoxicity.
Bates
S E
SE
Raphaelson
M I
MI
Price
R A
RA
McKeever
P
P
Cohen
S
S
Poplack
D G
DG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D002648:Child; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007278:Injections, Spinal; D007945:Leukemia, Lymphoid / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*; D011241:Prednisone / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012008:Recurrence; D013120:Spinal Cord Neoplasms / Q000134:cerebrospinal fluid / Q000473:pathology / Q000556:secondary*; D013736:Testicular Neoplasms / Q000134:cerebrospinal fluid / Q000473:pathology / Q000556:secondary; D014750:Vincristine / Q000008:administration & dosage
D004676:Myelin Basic Protein; D003561:Cytarabine; D014750:Vincristine; D001215:Asparaginase; D011241:Prednisone; D006854:Hydrocortisone; D008727:Methotrexate