Reduction of [3H]substance P binding in the intermediolateral cell column after sympathectomy.
Guanethidine-induced destruction of sympathetic postganglionic neurons in neonatal rats leads to transneuronal degeneration of the sympathetic preganglionic neurons. Using this model, we have been able to show a approximately 35% decrease in [3H]substance P ([3H]SP) binding in the intermediolateral cell column--suggesting that sympathetic preganglionic neurons possess substance P receptors. Our results show that [3H]substance P binding in the intermediolateral cell column is dependent on the integrity of sympathetic postganglionic neurons.
Takano
Y
Y
Loewy
A D
AD
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000378:metabolism; D006145:Guanethidine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000378:metabolism*
D013373:Substance P; D006145:Guanethidine