The effect of hypertension in pregnancy on fetal and neonatal condition.
The aim of this prospective study was to determine the effect of hypertension in pregnancy (PH) on fetal and neonatal condition via other mechanisms than retarded intrauterine growth and preterm delivery. Sixty-six preterm and 175 full-term babies born to PH mothers were compared, respectively, with 183 preterm and 220 full-term babies born to non-hypertensive (non-PH) mothers over a 22-month period in 1984-1986. Small-for-gestational-age (SGA) children were examined separately from appropriate-for-gestational-age (AGA) children. Percentages of preterm babies and of both preterm and full-term SGA babies born to hypertensive mothers were twice as great as the percentages of such babies born to non-hypertensive mothers. Hypertension in pregnancy directly increased neonatal morbidity, but the effect was minor. In preterm babies it was related to intrauterine growth retardation and to pre-eclampsia. In full-term babies the effect was unrelated to the severity of hypertension.
Martikainen
A M
AM
Department of Pediatrics and Obstetrics, Kuopio University Central Hospital, Finland.
Heinonen
K M
KM
Saarikoski
S V
SV
D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology; D011446:Prospective Studies; D012959:Socioeconomic Factors