Radiosensitivity of drug-resistant human tumour xenografts.
The radiosensitivity of three drug-resistant sublines of a human epidermoid lung carcinoma growing as xenografts in nude mice was investigated. Drug resistance to vincristine, actinomycin D and cisplatin was developed in vivo by repeated drug treatment. It was found that all three drug-resistant tumour lines were not cross-resistant to irradiation.
Mattern
J
J
Institute of Experimental Pathology, German Cancer Research Center, Heidelberg.
Bak
M
M
Hoever
K H
KH
Volm
M
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy*; D002945:Cisplatin / Q000494:pharmacology; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003609:Dactinomycin / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D011836:Radiation Tolerance; D011897:Random Allocation; D014750:Vincristine / Q000494:pharmacology
D003037:Cobalt Radioisotopes; D003609:Dactinomycin; D014750:Vincristine; D002945:Cisplatin