Preparation of a prolonged-release tablet formulation of diclofenac sodium. Part 1: Using chitosan.
Chitosan was used to prepare a prolonged-release tablet formulation of diclofenac sodium. Tablets were made by both direct-compression and wet granulation methods. The physical properties of tablets and granules were tested. The dissolution tests were performed by using USP dissolution and flow-through cell methods. A microcomputer program was used for the kinetic assessment of dissolution data. It was found that chitosan may be used for the preparation of the prolonged-release tablet of diclofenac sodium.
Acartürk
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Drug Research and Development Laboratory, FAKO Pharmaceuticals, Istanbul, Turkey.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002686:Chitin / Q000031:analogs & derivatives; D048271:Chitosan; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage*; D006244:Hardness; D007700:Kinetics; D010316:Particle Size; D011208:Powders; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D003692:Delayed-Action Preparations; D011208:Powders; D013607:Tablets; D002686:Chitin; D004008:Diclofenac; D048271:Chitosan