[Immunohistochemical localization of keratin and secretory component in carcinoma of the uterine cervix].
Carcinoma of the uterine cervix is said to frequently show a combination of squamous epithelial and glandular epithelial characteristics. In the present study, immunohistochemical localization of keratin and secretory component (SC) was studied to clarify these characteristics of cancers of the cervix, and the following results were obtained. Demonstration of the localization of keratin and SC was useful in providing functional markers of the squamous and glandular epithelium of the cervix. In epidermoid carcinomas, the squamous epithelial character of the keratinizing carcinomas was strongest and decreased in the large cell non-keratinizing, followed by the small cell non-keratinizing carcinomas. The glandular character of these lesions decreased in the same order. Subclassification of CIS did not reveal any major changes with either kind of staining. So-called bipotential differentiation was found in 21% of the epidermoid, 53% of the adenocarcinomas and 13% of the CIS. In the clinical stages of epidermoid carcinomas, the stage I and II cases more frequently showed squamous characteristics than did the stage 0 cases.
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D000230:Adenocarcinoma / Q000032:analysis / Q000276:immunology; D002278:Carcinoma in Situ / Q000032:analysis / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000276:immunology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007128:Immunoglobulin Fragments / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D012635:Secretory Component / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000276:immunology
D007128:Immunoglobulin Fragments; D012635:Secretory Component; D007633:Keratins