Pathology of small blood vessel disease in hypertension.
A pathogenic role for arterioles in hypertension has been postulated for many decades. Renal arteriolonecrosis, myointimal hyperplasia, and hyaline arteriolosclerosis are anatomic correlates of hypertension. The pathogenesis of these lesions is discussed as is contribution of these lesions to the perpetuation of hypertension. The importance of the extracellular matrix in the initiation and development of hyaline arteriolosclerosis is presented and correlated with the hemodynamic and pathophysiologic consequences of increased transmural pressure. The possibility of aiming therapy at arresting or ameliorating arteriolar disease is presented.
Kashgarian
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D001160:Arterioles / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D006801:Humans; D006818:Hyalin / Q000502:physiology; D006965:Hyperplasia; D006978:Hypertension, Renovascular / Q000209:etiology / Q000473:pathology*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D009336:Necrosis