Activated porcine alveolar macrophages: are biological response modifiers the answer?
We report that 75% of conventionally housed 3- to 4-week-old swine already have detectable activated alveolar macrophages as measured by cytotoxicity of tumor cells. These macrophages can not be further activated by the biological response modifier N-acetylmuramyl-L-alanyl-Disoglutamine-2H2O (MDP). These macrophages lose cytotoxic activity when cultured for 24 h and this loss of activity can not be reversed by MDP. We suggest that MDP biological response modifier therapy of swine alveolar macrophages may not be a useful technique in preventing respiratory disease in swine.
Chapes
S K
SK
Division of Biology, Kansas State University, Manhattan 66506.
Chitko
C G
CG
Thaler
R C
RC
Nelssen
J L
JL
Anderson
G A
GA
Blecha
F
F
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000818:Animals; D007155:Immunologic Factors / Q000494:pharmacology; D008262:Macrophage Activation; D011650:Pulmonary Alveoli / Q000166:cytology / Q000276:immunology*; D012140:Respiratory Tract Diseases / Q000517:prevention & control / Q000662:veterinary; D013552:Swine / Q000276:immunology*; D013553:Swine Diseases / Q000517:prevention & control
D007155:Immunologic Factors; D000119:Acetylmuramyl-Alanyl-Isoglutamine