Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.
Immunohistochemical studies showed that substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity co-exist in capsaicin-sensitive primary sensory neurons. Varicose SP- and CGRP-immunoreactive nerve fibres with a similar distribution pattern were seen in the lower airways and heart. The functional analysis revealed that CGRP caused cardiac stimulation and had, together with SP and neurokinin A, potent hypotensive effects. Vascular permeability was increased by SP and neurokinin A, and the bronchial smooth muscle was particularly sensitive to neurokinin A. Thus, multiple peptides stored in an possible released from the same nerve endings by capsaicin may exert differential effects in various target tissues.
Lundberg
J M
JM
Franco-Cereceda
A
A
Hua
X
X
Hökfelt
T
T
Fischer
J A
JA
D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000294:innervation; D066298:In Vitro Techniques; D008168:Lung / Q000294:innervation; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000502:physiology; D009475:Neurons, Afferent / Q000032:analysis*; D013373:Substance P / Q000032:analysis* / Q000502:physiology
D009419:Nerve Tissue Proteins; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin