title: Transport of hydrophobic ions in erythrocyte membrane: I. Zero membrane potential properties.
abstract: The permeability and partition coefficients of tetraphenylarsonium (TPA) and several other organic cations were studied in the human erythrocyte using an ion-selective electrode. The permeability constant for the different cations could be explained quite well by differences in oil/water partition coefficients. No evidence for facilitated transport could be found. Binding of the organic ions occurred to both the cell membrane and to intracellular contents. Partitioning to the membrane remained relatively constant despite variation from ion intracellular binding with blood samples from different donors. TPA flux is stimulated by substoichiometric amounts of tetraphenylboron and other organic anions, suggesting an ion-pairing mechanism.
authors.forename: A
authors.initials: A
authors.lastname: Hunziker
authors.forename: F W
authors.initials: FW
authors.lastname: Orme
authors.forename: R I
authors.initials: RI
authors.lastname: Macey
mesh_terms: D001152:Arsenicals / Q000097:blood; D002412:Cations; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008433:Mathematics; D008564:Membrane Potentials; D008954:Models, Biological; D013816:Thermodynamics
chemical_list: D001152:Arsenicals; D002412:Cations; D007473:Ion Channels; C009439:tetraphenylarsonium