Lack of association of HLA-DR4 with interleukin 1 beta secretion from peripheral blood monocytes in patients with rheumatoid arthritis.
The possible association between HLA-DR4 and interleukin 1 beta (IL-1 beta) secretion from peripheral blood monocytes was analyzed using 34 female patients, with definite rheumatoid arthritis (RA). RA monocytes in serum-free medium or medium supplemented with 10% fetal calf serum secreted IL-1 spontaneously. The level of secretion was enhanced by stimulation with pyrogen-free type II collagen as determined by comparison with 30 healthy individuals matched for age and sex. No association between HLA-DR4 and spontaneous or stimulated IL-1 release from RA monocytes was observed.
Goto
M
M
Division of Rheumatic Diseases, Tokyo Metropolitan Otsuka Hospital, Japan.
Sasano
M
M
Miyamoto
T
T
Nishioka
K
K
Nakamura
K
K
Aotsuka
S
S
Yokohari
R
R
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology; D005260:Female; D015804:HLA-DR4 Antigen / Q000032:analysis*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D012720:Severity of Illness Index
D015804:HLA-DR4 Antigen; D007375:Interleukin-1; D012710:Serum Albumin, Bovine; D003094:Collagen