title: Relative role of host and tumor in the growth pattern of murine and human neoplasms following subcutaneous transplantation in mice.
abstract: The growth patterns of two murine and eight human tumors, bilaterally implanted into subcutaneous tissue of groups of recipient mice, were studied. A Gompertz equation was fitted to experimental data for each individual implant and the Gompertz parameters were utilized as quantitative growth characteristics. The relative roles of the tumor-implanted flank (right versus left), of the individual host and of the tumor were analyzed by the paired t-test, simple linear regression model, one-way and two-way analysis of variance. Sixty pairs of Gompertz curves were obtained in seventy animals. Heterogeneity was the main characteristic of the growth pattern in all tumors under study, with a wide variability among the Gompertz parameters. Statistical analysis of experimental data showed that only the tumor systematically influenced the growth characteristics, whereas neither the tumor-implanted flank nor the individual host played a significant role. These results have both theoretical and practical implications.
authors.affiliation: Divisione di Radioterapia e Oncologia USSL 28, Legnago, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Demicheli
authors.forename: G
authors.initials: G
authors.lastname: Pratesi
authors.forename: R
authors.initials: R
authors.lastname: Foroni
authors.forename: M G
authors.initials: MG
authors.lastname: Barbagini
authors.forename: M
authors.initials: M
authors.lastname: Tortoreto
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002455:Cell Division; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D012044:Regression Analysis; D012878:Skin Neoplasms / Q000473:pathology*