Antigen- and isotype-specific regulation of IgE responses by Lyt 1+,2,3- and Lyt 1-,2,3+ T suppressor cells.
Antigen-specific, IgE isotype-selective suppression is induced following treatment of mice with a high-molecular-weight glutaraldehyde-polymerized ovalbumin preparation (OA-POL). The results show that the suppression is mediated by Lyt 1+,2,3- cells residing in the spleen. Adoptive transfer experiments indicate that Lyt 2,3+ or Lyt 1,2,3+ cells are not required for the establishment of suppression by these Lyt 1+,2,3- suppressor T cells (Ts). Treatment of OA-POL-induced Ts cells with anti-I-Jk serum and complement does not affect their ability to suppress. In marked contrast, spleen cells from animals treated with a single course of OA-POL almost 300 days previously, were shown to contain boosterable memory suppressor T cells (Tsm) which display the Lyt 1-,2,3+ phenotype. The activity of both Ts and Tsm cells appears to result from stimulation by determinants common to native OA and OA-POL rather than by idiotypic determinants expressed on anti-OA antibodies.
HayGlass
K T
KT
Strejan
G H
GH
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005976:Glutaral / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007116:Immunization, Passive; D007126:Immunoglobulin Allotypes / Q000502:physiology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000502:physiology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007156:Immunologic Memory; D051379:Mice; D008808:Mice, Inbred CBA; D010047:Ovalbumin / Q000276:immunology; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000145:classification*
D000950:Antigens, Ly; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin; D005976:Glutaral