Pharmacokinetics of mezlocillin in pleural fluid.
Mezlocillin concentrations in the pleural fluid and serum of six patients with malignant pleural effusion were determined following administration of 10 g mezlocillin over 30 minutes as a rapid infusion. Thirty minutes and eight hours after the infusion had been completed, concentrations of the active ingredient in the pleural fluid were 36.44 micrograms/ml and 112 micrograms/ml respectively; in the serum the respective values were 777.89 micrograms/ml and 44.22 micrograms/ml. The concentrations of active ingredient in the pleural fluid exceed the MIC for clinically significant pathogenic germs. The elimination half-life of mezlocillin in malignant pleural effusion is prolonged.
Mayer
M
M
Simon
U
U
Strosche
H
H
Schonfeld
W
W
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008802:Mezlocillin / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D010996:Pleural Effusion / Q000378:metabolism*
D008802:Mezlocillin