Cytochemical indices of leukocytes in patients with diabetes mellitus.
Cytochemical indices of leukocytes were determined in 16 patients with diabetes mellitus in the period of unbalancing and balancing. The following tests were made: content of glycogen and lipids, acid phosphatase (AP), alkaline phosphatase (AIP), myeloperoxidase (MPO) and nonspecific alpha-naphtol acetate esterase (NANAE) activity. In unbalanced diabetics an evident decrease in the activity of AP and MPO could be noted as well as a decrease of glycogen content and an increase of lipid content. An insignificant decrease could be observed in the activity of ALP and NANAE in granulocytes. A slight increase in the activity of NANAE in monocytes would be found. Balancing this disease induced the increase of all parameters in granulocytes except MPO activity. It is interesting to note that balancing diabetes mellitus deepened the observed changes in the decrease or increase of tested parameters. The presented findings clearly indicate the role of metabolic disorders in diabetes mellitus on the activity of some neutrophilic enzymes and the glycogen and the content of lipids in neutrophils.
Kemona
H
H
Podkowicz
K
K
Prokopowicz
J
J
D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006003:Glycogen / Q000097:blood; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009283:Naphthol AS D Esterase / Q000097:blood; D009195:Peroxidase / Q000097:blood
D008055:Lipids; D006003:Glycogen; D009195:Peroxidase; D009283:Naphthol AS D Esterase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase