P-fimbriae vaccines. I. Cross reactive antibodies to heterologous P-fimbriae.
To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with fimbriae purified from either Escherichia coli strain ER2 or strain JR1. The vaccinated animals showed elevated antibody titers to P-fimbriae from each of the E. coli strains used, suggesting cross-reactivity as was expected from the results of immunoprecipitation of the fimbriae. Enzyme-linked immunosorbent assay inhibition by heterologous P-fimbriae proved this to be true immunologic cross-reactivity.
Kaack
M B
MB
Department of Urology, Delta Regional Primate Research Center, Covington, LA 70433.
Pere
A
A
Korhonen
T K
TK
Svenson
S B
SB
Roberts
J A
JA
D000818:Animals; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines / Q000276:immunology*; D003429:Cross Reactions; D004926:Escherichia coli / Q000276:immunology* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000517:prevention & control; D010861:Fimbriae, Bacterial / Q000276:immunology*; D010215:Papio; D011704:Pyelonephritis / Q000517:prevention & control; D014774:Virulence / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines