Pharmacokinetic and pharmacodynamic interactions between single oral doses of ibopamine and food in normal man.
The pharmacokinetic and pharmacodynamic interactions between single oral doses of 200 mg ibopamine and a standard cold 3100 kJ meal were assessed in 12 normal male subjects, who were studied on 4 occasions, receiving either ibopamine or matched placebo (double-blind) in fasting condition or at the end of a meal. Treatments were randomly allocated in a period-balanced within-subject cross-over study design. The plasma concentrations of epinine (N-methyldopamine) were extensively profiled up to 4 h after dosing. Food caused a profound reduction of both Cmax and AUC of unconjugated epinine with a prolongation of Tmax. The subjects were furthermore profiled in detail up to 4 h after dosing by transthoracic impedance cardiography. Food caused substantial and protracted effects that affected virtually all parameters profiled. Ibopamine had clear cardiac performance enhancing effects only over the first hour after dosing. These effects were furthermore subject to significant food interaction. It therefore appeared that food resulted in a profound blunting of both ibopamine's pharmacokinetic and pharmacodynamic characteristics.
de Mey
C
C
SK&F-Institute for Applied Clinical Pharmacology, Göttingen, Fed. Rep. of Germany.
Enterling
D
D
Meineke
I
I
D000284:Administration, Oral; D000328:Adult; D003846:Deoxyepinephrine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000031:analogs & derivatives; D005502:Food; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male
C023487:ibopamine; D003846:Deoxyepinephrine