title: Changes in levels of mucosal glycoprotein on cysteamine-induced duodenal ulcers in rats.
abstract: Duodenal ulcers were induced in rats by cysteamine administration. Time-course changes in duodenal hexosamine, blood flow and intragastric pH were measured, as well as changes in the susceptibility of Brunner's glands to concanavalin A (Con A) staining. Hexosamine contents in the duodenum decreased significantly at 5 and 24 h. In the control group, Brunner's glands were stained brown using Con A staining. One day after cysteamine administration, the extent of Con A staining markedly decreased. At 3 and 7 days, gland susceptibility to staining was essentially the same as that of the control group.
authors.affiliation: Department of Internal Medicine, Tokyo Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Koga
authors.forename: Y
authors.initials: Y
authors.lastname: Nonaka
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: T
authors.initials: T
authors.lastname: Seki
authors.forename: H
authors.initials: H
authors.lastname: Kon
authors.forename: M
authors.initials: M
authors.lastname: Tsurui
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ashizawa
mesh_terms: D000818:Animals; D002011:Brunner Glands / Q000378:metabolism; D003208:Concanavalin A; D003543:Cysteamine / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced*; D004386:Duodenum / Q000098:blood supply / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000098:blood supply; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D006023:Glycoproteins; D006595:Hexosamines; C047874:gastric mucus glycoproteins; D003208:Concanavalin A; D003543:Cysteamine