title: [Autoimmune reactions against interleukin-2 receptors in patients with blood system diseases and in experimental Rauscher retrovirus leukemia].
abstract: Apart from autoimmune reactions, antibodies to IL-2 receptors were identified in blood sera of linear mice during leukemogenesis. It is indicated that in the course of leukemia establishment, there can be demonstrated antibodies capable of blocking IL-2 receptors on the membrane of activated T lymphocytes and inhibiting IL-2-dependent proliferation of T cells. The blood sera of patients suffering from chronic lymphoid leukemia, acute lymphoblastic leukemia, lymphocytomas, pure red-cell aplasia, and aplastic anemia showed antibodies against IL-2 receptors. Out of the total number of 52 patients, 23 demonstrated those antibodies. The data obtained should be taken into account in the patients' management using IL-2.
authors.forename: V S
authors.initials: VS
authors.lastname: Ter-Grigorov
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
authors.forename: V A
authors.initials: VA
authors.lastname: Novikov
authors.forename: Z Kh
authors.initials: ZKh
authors.lastname: Mamiliaeva
authors.forename: O Ia
authors.initials: OIa
authors.lastname: Moskovkina
mesh_terms: D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D005260:Female; D006402:Hematologic Diseases / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology*; D051379:Mice; D011925:Rauscher Virus; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015375:Receptors, Interleukin-2
vernacular_title: Autoimmunnye reaktsii protiv retseptorov dlia interleĭkina-2 u bol'nykh s nekotorymi zabolevaniiami sistemy krovi i pri éksperimental'nom retrovirusnom leĭkoze Raushera.