Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation.
By combination of chemical, 1H and 13C NMR, and mass spectrometric studies, the structures of the three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carrying a dimannosyl group and are differentiated by the presence of various acylamide moieties, derived from C8, C9 and C10 fatty acids.
Ciabatti
R
R
Merrell Dow Research Institute-Lepetit Research Center, Gerenzano, Italy.
Kettenring
J K
JK
Winters
G
G
Tuan
G
G
Zerilli
L
L
Cavalleri
B
B
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D005227:Fatty Acids / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006020:Glycopeptides / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008745:Methylation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000032:analysis; D010456:Peptides, Cyclic; D013053:Spectrophotometry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D005227:Fatty Acids; D006020:Glycopeptides; D010446:Peptide Fragments; D010456:Peptides, Cyclic; C041438:ramoplanin