title: Testicular proteins, nucleic acids and their synthesis following gamma irradiation.
abstract: The effects of two doses (250 and 1000 rads) of local gamma irradiation on testes of adult rats are reported after 1, 2, 4 and 16 weeks. There was a significant increase in DNA content per gm testes at 1 week; a gradual decrease at 2 and 4 week intervals was followed by a trend towards recovery at 16 weeks post-irradiation. The rate of synthesis of both DNA and RNA as studied by the incorporation of (3H)-thymidine and (3H)-uridine, showed similar results. Total protein content per gm testis declined with both doses and at all post-irradiation intervals. Histological observation showed loss of spermatogenic cells suggestive of DNA loss.
authors.affiliation: Department of Biophysics, Panjab University, Chandigarh, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Bansal
authors.forename: A
authors.initials: A
authors.lastname: Kaul
authors.forename: B
authors.initials: B
authors.lastname: Nehru
mesh_terms: D000818:Animals; D008297:Male; D009696:Nucleic Acids / Q000096:biosynthesis / Q000378:metabolism / Q000528:radiation effects*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D012671:Seminiferous Tubules / Q000528:radiation effects / Q000648:ultrastructure; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D009696:Nucleic Acids; D011506:Proteins