Effect of fipexide on passive avoidance behaviour in rats.
The effect of fipexide, administered at different intervals after the learning trial of a single step-through type passive avoidance situation was studied. The administration of fipexide immediately after the learning trial resulted in a long-lasting facilitation of passive avoidance behaviour. On the contrary, the administration of this compound 1 h prior to the retention test failed to influence passive avoidance behaviour. The results suggest that fipexide facilitates memory consolidation but does not influence retrieval processes.
Serra
G
G
Department of Neurosciences, University of Cagliari, Italy.
Collu
M
M
Martellotta
M C
MC
Forgione
A
A
Fratta
W
W
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010879:Piperazines; C038628:fipexide