A possible mechanism of tumor regression in cisplatin-treated mice.
Immunization of mice with cisplatin results in specific enhancement of host's cellular immune system by stimulating splenocytes and peritoneal exudate cells against the specific tumor antigens. Possible mechanism of tumor cell destruction by splenocytes/PEC was analyzed. Intimate contact between the two cells is the most essential step during the tumor effector cell reaction.
Sarna
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Department of Zoology, Gauhati University, Guwahati, India.
Sodhi
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Bhola
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D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D002945:Cisplatin