[The action of cisplatin on the developing meso- and metanephros of chick embryos].
Injection of various doses of cisplatin to 2-14-day chick embryos showed that within 2-8 days of incubation cisplatin produces total toxic effect, the number of dead embryos being dependent on a dose of the drug. Within 9-16 days of incubation, i.e. a period when both the mature mesonephros and the developing metanephros are in action, no significant changes were observed in the content of urea and uric acid, the weight of the meso- and metanephros, their water content, and ion content of the blood. Electron microscopic studies revealed no structural changes in the renal tubules. The data obtained suggest that cisplatin does not produce any nephrotoxic effect in chick embryos irrespectively of their age.
Zemanová
Z
Z
Bakhteeva
V T
VT
Gambarian
S P
SP
Tichý
V
V
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002642:Chick Embryo; D002945:Cisplatin / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D008650:Mesonephros / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D008854:Microscopy, Electron; D011247:Pregnancy; D013997:Time Factors
D002945:Cisplatin
Osobennosti deĭstviia tsis-platina na razvivaiushchiĭsia mezo- i metanefros kurinykh émbrionov.