IgM class antibodies to intercellular substance in massive cutaneous hyalinosis: occurrence and relation to antigluten and antihyalin antibodies.
High levels of circulating IgM class antibodies to intercellular substance were found in massive cutaneous hyalinosis, a systemic kappa light chain disease characterized by hyalin deposits in skin and gut. A strong humoral immune response to the accumulating mannose-rich hyalin glycoprotein and to wheat gluten was also demonstrated. Both gluten and the hyalin protein, when added to serum, abolished the immunofluorescence staining of the intercellular cement, suggesting that there may exist common antigenic sites in the hyalin protein, gluten, and intercellular substance.
Maury
C P
CP
Räsänen
J A
JA
Teppo
A M
AM
D000368:Aged; D000906:Antibodies / Q000032:analysis; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D005260:Female; D005455:Fluorescent Antibody Technique; D005983:Glutens / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D006818:Hyalin / Q000276:immunology* / Q000378:metabolism; D007075:Immunoglobulin M / Q000032:analysis*; D012871:Skin Diseases / Q000276:immunology*; D016326:Extracellular Matrix Proteins
D000906:Antibodies; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D005983:Glutens; D006023:Glycoproteins; D007075:Immunoglobulin M; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins