title: n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog.
abstract: n-Decyl-NHpppA2'p5'A2'p5'A, a gamma-substituted, phosphatase-resistant pppA2'p5'A2'p5'A analog, gives similar rRNA degradation pattern in interferon-treated HeLa cell extracts--even at a concentration of 10(-9)M--as the natural compound does.
authors.forename: K
authors.initials: K
authors.lastname: Karikó
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D004722:Endoribonucleases / Q000378:metabolism*; D004789:Enzyme Activation; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D009841:Oligonucleotides / Q000494:pharmacology*; D009843:Oligoribonucleotides / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D012335:RNA, Ribosomal; D007372:Interferons; C054205:P(1)-adenylyl-5'-2'-adenylyl-5'-2'-adenosyl-P(3)-n-decylaminotriphosphate; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease; D000469:Alkaline Phosphatase