title: Use of the crushing strength parameter for quality control of phenobarbital-microcrystalline cellulose tablets.
abstract: Three variables of the tablet manufacturing process (duration of mixing with lubricant, maximum compression force and compression rate) were studied for their effects on various properties of direct compression phenobarbital-microcrystalline cellulose tablets. Mixing time and maximum compression force were found to have a marked influence on friability and dissolution rate; crushing strength was found to be a useful parameter for quality control.
authors.affiliation: Departamento De Farmacología, Farmacia Y Technología Farmacéutica Facultad De Farmacia, Santiago De Compostela, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Souto
authors.forename: J L
authors.initials: JL
authors.lastname: Gómez-Amoza
authors.forename: M
authors.initials: M
authors.lastname: Landín
authors.forename: J L
authors.initials: JL
authors.lastname: Vila-Jato
authors.forename: A
authors.initials: A
authors.lastname: Concheiro
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Pacheco
mesh_terms: D002482:Cellulose; D006244:Hardness; D010634:Phenobarbital / Q000008:administration & dosage / Q000032:analysis*; D011786:Quality Control; D012044:Regression Analysis; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D002482:Cellulose; D010634:Phenobarbital