title: trans-activation by the hepatitis B virus X protein shows cell-type specificity.
abstract: The hepatitis B virus X protein can trans-activate transcription from many viral promoters. We show here that this trans-activation is cell-type but not species specific, and that only a subset of promoters is trans-activated in any particular cell type. Furthermore, the T/t-antigens from simian virus 40 suppress this trans-activation. We hypothesize that the X protein acts via cellular factors which are phylogenetically conserved and developmentally regulated and whose effects are blocked by the T/t-antigens.
authors.affiliation: Department of Pathology, University of California, San Francisco 94143.
authors.forename: E
authors.initials: E
authors.lastname: Seto
authors.forename: D X
authors.initials: DX
authors.lastname: Zhou
authors.forename: B M
authors.initials: BM
authors.lastname: Peterlin
authors.forename: T S
authors.initials: TS
authors.lastname: Yen
mesh_terms: D000818:Animals; D002460:Cell Line; D006515:Hepatitis B virus / Q000235:genetics* / Q000502:physiology; D006801:Humans; D011401:Promoter Regions, Genetic; D013045:Species Specificity; D015534:Trans-Activators / Q000235:genetics*; D015533:Transcriptional Activation; D014162:Transfection; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein