High-performance liquid chromatographic determination of tilidine in pharmaceutical dosage forms.
A reversed-phase high performance liquid chromatographic method for the determination of tilidine in bulk drug and its liquid and solid dosage forms is described. The method uses reversed-phase column RP-8 with methanol -0.2% water solution of ammonium carbonate (75:25,v/v) as the mobile phase and UV detector. The time taken for separation is 6.17 min. The response is linear up to 3.6 mmol/l, with recovery levels ranging from 98.2 to 101.2%. The present method is rapid, simple and reproducible.
Zivanov-Stakić
D
D
Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Solomun
L J
LJ
Zivanović
L J
LJ
D002851:Chromatography, High Pressure Liquid; D003509:Cyclohexanecarboxylic Acids / Q000032:analysis*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013993:Tilidine / Q000032:analysis*
D003509:Cyclohexanecarboxylic Acids; D012996:Solutions; D013993:Tilidine