P-fimbriae vaccines. II. Cross reactive protection against pyelonephritis.
Protection against acute pyelonephritis was induced by immunization of baboons with purified P-fimbriae of Escherichia coli as vaccines. To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with P-fimbriae purified from either E. coli strain ER2 or strain JR1 and subsequently challenged the animals with E. coli strain JR1. All vaccinated animals showed elevated antibody titers to P-fimbriae from both of the E. coli strains used. Both vaccines tended to reduce the time of bacteriuria. They partially prevented pyelonephritis and protected against loss of renal function.
Roberts
J A
JA
Department of Urology, Delta Regional Primate Research Center, Covington, LA 70433.
Kaack
M B
MB
Baskin
G
G
Korhonen
T K
TK
Svenson
S B
SB
Winberg
J
J
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003429:Cross Reactions; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000517:prevention & control*; D010861:Fimbriae, Bacterial / Q000276:immunology*; D010215:Papio; D011704:Pyelonephritis / Q000517:prevention & control*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines