New synthetic retinoids: effects on proliferation and differentiation.
Nine retinoid analogues were synthesized and their effects on cell proliferation and differentiation of tumor cell lines were analysed and compared with those of natural retinoids (retinoic acid, retinol, retinal). Our results demonstrate differential inhibitory effects of the synthetic retinoids on cell growth. This inhibitory activity of the synthetic retinoids was, in some cases, higher than that of retinoic acid and retinol. Natural and synthetic retinoids were found to be able to induce to a different extent erythroid differentiation of murine erythroleukemia cells and adipogenic conversion of Chinese Hamster FHO6N1-1 cells. Our data suggest that studies on the relationship between structure and biological activity could be approached by using the analysed synthetic retinoids.
Nastruzzi
C
C
Department of Pharmaceutical Science, Ferrara University, Italy.
Simoni
D
D
Manfredini
S
S
Barbieri
R
R
Feriotto
G
G
Baraldi
P G
PG
Spandidos
D
D
Guarneri
M
M
Gambari
R
R
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D015195:Drug Design; D005622:Friend murine leukemia virus; D007202:Indicators and Reagents; D007942:Leukemia, Experimental; D051379:Mice; D012176:Retinoids / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects
D007202:Indicators and Reagents; D012176:Retinoids