title: Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats.
abstract: Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 microM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 microM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.
authors.affiliation: Department of Pharmacology, Mount Sinai School of Medicine, CUNY 10029-6574.
authors.forename: S G
authors.initials: SG
authors.lastname: Beck
authors.forename: W P
authors.initials: WP
authors.lastname: Clarke
authors.forename: J
authors.initials: J
authors.lastname: Goldfarb
mesh_terms: D000818:Animals; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D012701:Serotonin; D004958:Estradiol