Distribution of keratin proteins in neoplastic and tumorlike lesions of squamous epithelium. An immunohistochemical study.
Seventy-six cases of tumorlike and neoplastic lesions from epidermis and oral epithelium were analyzed by a histochemical technique for the demonstration of keratin. Formalin-fixed paraffin sections were reacted with rabbit antihuman keratin antiserum (dilution of 1:40). The types of distribution of keratin in cells of lesions were classified into five categories: (1) regional, as found in normal squamous epithelia and benign hyperkeratinized lesions, and papilloma, and keratinized squamous cell carcinoma; (2) total, as seen in intensely keratinized lesions, such as verruca vulgaris and highly keratinized squamous cell carcinoma; (3) negative, as displayed by basal cell carcinoma; (4) scattered, as in the most poorly differentiated squamous cell carcinomas; and (5) mixed cellular, as found in both poorly and moderately differentiated squamous cell carcinomas.
Mori
M
M
Nakai
M
M
Hyun
K H
KH
Noda
Y
Y
Kawamura
K
K
D002280:Basal Cell Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D012628:Dermatitis, Seborrheic / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D007642:Keratosis / Q000473:pathology; D037102:Lectins / Q000378:metabolism; D009062:Mouth Neoplasms / Q000473:pathology*; D010212:Papilloma / Q000473:pathology; D011485:Protein Binding; D012878:Skin Neoplasms / Q000473:pathology*; D014860:Warts / Q000473:pathology
D037102:Lectins; D007633:Keratins