[Abnormality of T cell subsets in patients with idiopathic thrombocytopenic purpura].
Fifty patients with idiopathic thrombocytopenic purpura (ITP) and 50 normal controls were studied for T cell subsets using OKT monoclonal antibodies. These patients were found to have lower proportions of OKT4+ subset and higher proportions of OKT8+ ratio than the healthy controls. The perturbation was more severe in patients with active disease. A significant increase of OKT 4+8+ double-labelled cells deduced by a subtraction method was also observed in the peripheral blood of patients and an inverse correlation was demonstrated between the proportions of OKT4+8+ subset and the platelet counts. Furthermore, a positive correlation between the proportions of OKT4-8+ subset and the platelet counts was also found in patients with active ITP. These data suggest that abnormalities of T cell subsets in the peripheral blood may play an important role in the pathogenesis of ITP.
Song
L J
LJ
Yu
J R
JR
Ma
S J
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal