Efficacy of ivermectin in the treatment of induced Parascaris equorum infection in pony foals.
Eighteen pony foals inoculated with 1,500 +/- 109 infective Parascaris equorum eggs were given 0.02 ml of ivermectin vehicle (liquid)/kg of body weight, PO, (control); 0.2 mg of ivermectin paste/kg, PO; or 0.2 mg ivermectin liquid/kg, PO, on postinoculation day (PID) 28. Foals were euthanatized on PID 42, and the small intestinal contents were examined for P equorum larvae. The mean number of fourth-stage P equorum larvae in foals treated with ivermectin paste and liquid were 3.5 and 6, respectively. Significantly (P less than 0.01) higher mean numbers of larvae (1,250) were detected in foals treated with ivermectin vehicle. Larvae recovered from foals treated with ivermectin vehicle were of significantly (P less than 0.002) longer mean length than those from foals treated with ivermectin paste or liquid. Gross examination of lungs and liver revealed similar pathologic changes from the migration of P equorum in all foals. Adverse reaction to treatment was not observed.
DiPietro
J A
JA
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Lock
T F
TF
Todd
K S
KS
Davis
J L
JL
D000818:Animals; D001199:Ascaridoidea / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007421:Intestine, Small / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects / Q000302:isolation & purification; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009824:Ointments
D009824:Ointments; D007559:Ivermectin