title: Effects on intestinal nutrient uptake and brush border membrane enzymes in response to atherogenic diet in rhesus monkeys.
abstract: Transport of nutrients and kinetic parameters (Vmax and Km) of brush border membrane (BBM) enzymes were studied in duodenum, jejunum, and ileum from atherogenic diet-fed monkeys. The Km remained unaltered while feeding of atherogenic diet resulted in higher Vmax of sucrase, maltase, and alkaline phosphatase and lower Vmax of gamma-glutamyltranspeptidase and leucine-aminopeptidase compared to controls. Na+-dependent D-glucose transport was higher in duodenum and jejunum and unaltered in ileum. In contrast to D-glucose transport, the transport of amino acids was decreased in all three intestinal segments from atherogenic diet-fed monkeys.
authors.affiliation: Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Dhaunsi
authors.forename: G S
authors.initials: GS
authors.lastname: Sidhu
authors.forename: U C
authors.initials: UC
authors.lastname: Garg
authors.forename: Y
authors.initials: Y
authors.lastname: Singh
authors.forename: R N
authors.initials: RN
authors.lastname: Chakravarti
authors.forename: R
authors.initials: R
authors.lastname: Bhatnagar
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004036:Diet, Atherogenic; D004386:Duodenum / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D005947:Glucose / Q000378:metabolism; D007082:Ileum / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D007421:Intestine, Small / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D007583:Jejunum / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008253:Macaca mulatta; D008871:Microvilli / Q000201:enzymology; D013393:Sucrase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D013393:Sucrase; D007931:Leucyl Aminopeptidase; D005947:Glucose