title: Interaction of Campylobacter jejuni with extracellular matrix components.
abstract: The adhesion of three strains of Campylobacter jejuni to coverslips and microwells coated with isolated extracellular matrix components, fibronectin, laminin and types I, III, IV and V collagens was studied. Fibronectin mediated the adherence of C. jejuni, but there were differences in the binding capacities of the strains. Type I, III and V collagens mediated very strongly the attachment of two strains of C. jejuni. All three strains attached weakly to basement membrane-specific type IV collagen. Laminin was capable of mediating the adhesion only when present at a higher concentration. The observations indicate that extracellular matrix components may serve as anchor molecules for C. jejuni adhesion and that several attachment mechanisms occur simultaneously.
authors.affiliation: Department of Bacteriology, University of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kuusela
authors.forename: A P
authors.initials: AP
authors.lastname: Moran
authors.forename: T
authors.initials: T
authors.lastname: Vartio
authors.forename: T U
authors.initials: TU
authors.lastname: Kosunen
mesh_terms: D001422:Bacterial Adhesion; D001485:Basement Membrane / Q000382:microbiology; D002168:Campylobacter fetus / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000382:microbiology*; D005353:Fibronectins / Q000378:metabolism; D007797:Laminin / Q000378:metabolism
chemical_list: D005353:Fibronectins; D007797:Laminin; D003094:Collagen