title: Variations of sotalol kinetics in renal insufficiency.
abstract: Decreased elimination of sotalol (160 mg) is found in patients with renal insufficiency. Simulation of plasma concentrations at steady-state exhibits moderately higher concentrations when creatinine clearance is between 10 and 30 ml/min and very high plasma concentrations when creatinine clearance is less than 10 ml/min suggesting, if treatment is absolutely necessary, monitoring in these cases and the reduction of the dose in major renal insufficiency.
authors.affiliation: Départment de Pharmacologie Clinique, Hopital Général, CHRU, Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Dumas
authors.forename: P
authors.initials: P
authors.lastname: d'Athis
authors.forename: J F
authors.initials: JF
authors.lastname: Besancenot
authors.forename: V
authors.initials: V
authors.lastname: Chadoint-Noudeau
authors.forename: J M
authors.initials: JM
authors.lastname: Chalopin
authors.forename: G
authors.initials: G
authors.lastname: Rifle
authors.forename: A
authors.initials: A
authors.lastname: Escousse
mesh_terms: D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D012307:Risk Factors; D013015:Sotalol / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D013015:Sotalol; D003404:Creatinine