PAF-acether-induced mortality in mice: protection by benzodiazepines.
Intraperitoneal injection to mice of platelet-activating factor (PAF) induces severe shock symptoms, leading to death. The effects of various drugs which are potential specific or non-specific PAF inhibitors were tested. Salbutamol, a beta 2-agonist, showed a partial protection, whereas the specific PAF antagonists CV 3988 or BN 52021 induced an important beneficial action against PAF-induced lethal effects. The effects of drugs related to benzodiazepines were also studied: alprazolam administered p.o. prior to PAF challenge provides almost complete protection against PAF toxicity. Thus PAF-induced death in mice represents a useful model of systemic anaphylaxis; moreover, studies of benzodiazepine-related compounds may be interesting for investigating the mechanisms of the biological actions of PAF.
Tannière-Zeller
M
M
Laboratory of Pharmacodynamics, Faculty of Pharmacy, Dijon, France.
Rochette
L
L
Bralet
J
J
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D002417:Cattle; D003643:Death; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000633:toxicity*; D011738:Pyrilamine / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D010936:Plant Extracts; D010972:Platelet Activating Factor; D014230:Triazoles; D001569:Benzodiazepines; D011738:Pyrilamine; D000420:Albuterol