Release of [3H]dopamine from rat prefrontal cortex: modulation through presynaptic cholinergic heteroreceptors.
The release of tritiated dopamine ([3H]DA) from slices of the rat prefrontal cortex was studied using a superfusion technique. Release appeared to be voltage-dependent and also dependent on external Ca2+, suggesting the presence of a specific neurotransmitter release mechanism. gamma-Aminobutyric acid (GABA), aspartate, glutamate and serotonin had no effect on either basal DA release or K(+)-stimulated release. Carbachol, a cholinergic agonist, inhibited K(+)-stimulated DA release. The results demonstrate that cholinergic heteroreceptors on dopaminergic terminals of the prefrontal cortex modulate DA release.
Jaffé
E H
EH
Laboratorio de Neuroquimica, Instituto Venezolano de Investigaciones Cientificas, Caracus, Venezuela.
Hernández
N
N
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D002121:Calcium Channel Blockers; D002217:Carbachol / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D008297:Male; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D010275:Parasympathetic Nervous System / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D013569:Synapses / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002121:Calcium Channel Blockers; D005971:Glutamates; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D001224:Aspartic Acid; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002217:Carbachol; D011188:Potassium; D004298:Dopamine