Synaptic interaction between catecholaminergic neurons and substance P-immunoreactive axons in the caudal part of the nucleus of the solitary tract of the rat: demonstration by the electron microscopic mirror technique.
The 'mirror technique' was applied in immunoelectron microscopy to demonstrate the synaptic relationship between neuronal structures containing catecholamines and substance P in the caudal part of nucleus of the solitary tract in the rat, using antisera against tyrosine hydroxylase and substance P. Substance P-immunoreactive axon terminals were shown to make two types of synaptic contacts (asymmetrical and symmetrical) with catecholaminergic neurons. It is concluded that substance P afferents can directly affect catecholaminergic neurons in this nucleus via synapses.
Kubota
Y
Y
Takagi
H
H
Morishima
Y
Y
Powell
J F
JF
Smith
A D
AD
D000818:Animals; D007124:Immunoenzyme Techniques; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D008854:Microscopy, Electron; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D013373:Substance P; D014446:Tyrosine 3-Monooxygenase