Genetic structure of the abd-A gene of Drosophila.
We report the embryonic and adult phenotypes of a number of mutations of the abd-A gene of the bithorax complex. Some of them result in loss of abd-A function in the whole abd-A domain and are usually lethal. These probably eliminate or inactivate abd-A protein products. Other mutations affect only part of the abd-A domain. These are viable, appear to map outside the abd-A transcription unit, and presumably alter the normal spatial regulation of abd-A products. We propose a model of abd-A structure based on a protein-coding region and two cis-regulatory regions. Regulatory region 1, 3' to the transcription unit, contains positive and negative regulatory elements. Regulatory region 2, 5' to the transcription unit, establishes the correct level of abd-A activity in the abdominal metameres.
Busturia
A
A
Centro de Biología Molecular, Universidad Autónoma de Madrid, Spain.
Casanova
J
J
Sánchez-Herrero
E
E
González
R
R
Morata
G
G
D000818:Animals; D002874:Chromosome Mapping; D004330:Drosophila / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D005796:Genes / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics; D005816:Genetic Complementation Test; D009154:Mutation