title: Regional differences in adrenal activation of spironolactone: relationship to steroid 17 alpha-hydroxylase activity.
authors.affiliation: Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science, PA 19104.
authors.forename: J H
authors.initials: JH
authors.lastname: Sherry
authors.forename: P B
authors.initials: PB
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Levitt
authors.forename: J
authors.initials: J
authors.lastname: Bergstrom
authors.forename: H D
authors.initials: HD
authors.lastname: Colby
mesh_terms: D000311:Adrenal Glands / Q000201:enzymology* / Q000648:ultrastructure; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004789:Enzyme Activation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D013148:Spironolactone / Q000378:metabolism*; D013254:Steroid 17-alpha-Hydroxylase / Q000378:metabolism*; D013250:Steroid Hydroxylases / Q000378:metabolism*
chemical_list: D013148:Spironolactone; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D013250:Steroid Hydroxylases; D013254:Steroid 17-alpha-Hydroxylase