Effect of placental laterality on uterine artery resistance and development of preeclampsia and intrauterine growth retardation.
We studied 153 pregnant women with normal pregnancies and 147 women with complicated pregnancies (diabetes, hypertensive disorders, and intrauterine growth retardation) to evaluate the association of placental location and the development of preeclampsia, intrauterine growth retardation, and uterine artery resistance. The placental location was determined by real-time ultrasonography, and the uterine artery resistance was determined by continuous-wave Doppler flow velocity waveform analysis. In the presence of preeclampsia or intrauterine growth retardation, up to 75% of the patients had unilaterally located placentas and 25% central placentas, whereas in the absence of these two conditions only 51% of the patients had unilateral and 49% central placentas (p less than 0.02). In patients with unilateral placentas, the incidence of preeclampsia and intrauterine growth retardation was 2.8-fold and 2.7-fold greater than in patients with central placentas (p less than 0.03 and p less than 0.01). Among all patients unilateral placental location was more likely to be associated with abnormal artery flow velocity waveforms than central placental location (p less than 0.001). We conclude that unilateral placental location may predispose to the development of preeclampsia and intrauterine growth retardation by its effect on uterine artery resistance.
Kofinas
A D
AD
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
Penry
M
M
Swain
M
M
Hatjis
C G
CG
D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D010920:Placenta / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance / Q000502:physiology*