title: [Anti H2 receptors and perforated peptic ulcer. Review of 442 cases].
abstract: H2 blockers have accelerated the reduction in elective peptic ulcer surgery but appear to have had no equivalent effect on the incidence of perforated ulcer success. A 13 year (1975-1987) review of perforated peptic ulcer is presented. The mean annual number of operations for perforation fell from 8.21% to 4.93% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged. A significant reduction was found in mean annual rates for perforated duodenal ulcer from 6.86% to 3.82% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged.
authors.forename: V
authors.initials: V
authors.lastname: Mastroianni
authors.forename: M
authors.initials: M
authors.lastname: Calgaro
authors.forename: S
authors.initials: S
authors.lastname: Manfredi
authors.forename: R
authors.initials: R
authors.lastname: Manzini
authors.forename: S
authors.initials: S
authors.lastname: Bevilacqua
mesh_terms: D015331:Cohort Studies; D004381:Duodenal Ulcer / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010439:Peptic Ulcer Perforation / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D006635:Histamine H2 Antagonists
vernacular_title: Anti H2 recettori e ulcera peptica perforata. Revisione di 442 casi.