title: Evidence for a major additive gene in ulcerative colitis.
abstract: Complex segregation analysis of 124 families with ulcerative colitis with two or more affected individuals suggests a rare additive major gene causing the disease with about 20% affected among the heterozygotes for the gene. There was no evidence for multifactorial inheritance.
authors.affiliation: Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Monsén
authors.forename: L
authors.initials: L
authors.lastname: Iselius
authors.forename: C
authors.initials: C
authors.lastname: Johansson
authors.forename: G
authors.initials: G
authors.lastname: Hellers
mesh_terms: D003093:Colitis, Ulcerative / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D005810:Multigene Family; D009679:Nuclear Family; D010375:Pedigree