Enhancement of plaque formation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) by subinhibitory dose of acyclovir (ACV).
Acyclovir (9-/2-hydroxyethoxymethyl/guanine) enhanced the plaque formation of HSV and VZV at subinhibitory dose and inhibited at higher concentration but not in thymidine kinase deficient viruses. The enhancement was neutralized by thymidine. Induction of viral thymidine kinase activity was not affected with ACV. These results suggest that the enhancement may be mediated by viral thymidine kinase.
Shiraki
K
K
Department of Virology, Osaka University, Japan.
Miyaki
C
C
Namazue
J
J
Yamanishi
K
K
Takahashi
M
M
D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D013936:Thymidine / Q000494:pharmacology; D013937:Thymidine Kinase / Q000172:deficiency / Q000378:metabolism; D010948:Viral Plaque Assay
D013937:Thymidine Kinase; D013936:Thymidine; D000212:Acyclovir