title: [Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer].
abstract: The paper is devoted to the description of the combined methods of radiotherapy of urinary bladder cancer and the local use of metronidazole. At the 1st stage of therapy a dose of 140 cGy twice a day with 5-6 h interruption was delivered up to a summary dose of 43 Gy on conversion to small fractionation by the TDF factor. Then two fractions at a single dose of 6 Gy once a week were given. Altogether 36 patients were treated by this method. The control group of patients was given radiation therapy in a split course in the regimen of routine fractionation. Short-term therapeutic results were analyzed for both groups. The total positive effect was higher in the study group (81.25% versus 66.7%). A conclusion is that this method holds promise.
authors.forename: I A
authors.initials: IA
authors.lastname: Pereslegin
authors.forename: A G
authors.initials: AG
authors.lastname: Vinogradskiĭ
authors.forename: F F
authors.initials: FF
authors.lastname: Mufazalov
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
chemical_list: D008795:Metronidazole
vernacular_title: Dinamicheskoe fraktsionirovanie dozy izlucheniia v sochetanii s mestnym primeneniem metronidazola pri rake mochevogo puzyria.