Characterization of eight VNTR loci by agarose gel electrophoresis.
Allelic frequencies and their confidence intervals were obtained for eight independent VNTR loci from a sample of more than 75 Utah Caucasians. Using high-resolution agarose gel electrophoresis, we were able to resolve alleles at the D17S5 locus that differed by only one repeating unit; it was therefore possible to name the alleles according to the number of repeating units each contained. Two a priori probabilities were calculated for each VNTR locus separately and for all eight loci jointly: (i) the "power of exclusion" for an alleged father/mother/child trio and for an alleged parent/child duo, and (ii) the "probability of matching" when two unrelated individuals or two siblings are genotyped.
Odelberg
S J
SJ
Department of Human Genetics, University of Utah Medical Center, Salt Lake City, 84132.
Plaetke
R
R
Eldridge
J R
JR
Ballard
L
L
O'Connell
P
P
Nakamura
Y
Y
Leppert
M
M
Lalouel
J M
JM
White
R
R
D000483:Alleles; D004587:Electrophoresis, Agar Gel; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011336:Probability; D012091:Repetitive Sequences, Nucleic Acid