[Functional status, myocardial metabolism and immunologic shifts in experimental myocardial infarction and its treatment with cyclophosphamide and 6-mercaptopurine].
The influence of cyclophosphamide immunodepressants and 6-mercaptopurine on the electrocardiogram shifts, myocardial metabolism and humoral and cellular immunity indices has been studied on the dogs with experimental infarction. The results of the investigation show the incongruity to use cyclophosphamide immunodepressants and 6-mercaptopurine under myocardial infarction as they inhibit immunological reactivity, deteriorate coronary circulation and myocardial metabolism as well as retard reparative processes in the cardiac muscle.
Akse'lrod
L B
LB
Shvedov
L M
LM
Ma'ltsev
E V
EV
Sukolovskaia
D M
DM
Kravchenko
L S
LS
Rasina
D G
DG
Kadyrova
L L
LL
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D007109:Immunity / Q000187:drug effects / Q000276:immunology*; D015122:Mercaptopurine / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*
D003520:Cyclophosphamide; D015122:Mercaptopurine
Funktsiona'lnoe sostoianie, metabolizm miokarda i immunologicheskie sdvigi organizma pri éksperimenta'lnom infarkte miokarda i ego lechenii tsiklofosfanom i 6-merkaptopurinom.