Liver cell protection in toxic liver lesion.
Most of the hepatoprotective drugs belong to the group of free radical scavangers. The mechanism of their action involves membrane stabilisation, neutralisation of free radicals and immunomodulation. The authors demonstrate the effect of different-drugs used in therapy of liver diseases (silymarin, silibinin, Aica-P) in human clinico-pharmacological study and in animal experiments. A wide number of methods was used. Both the silymarin preparates and the Aica-P corrected the altered immunreaction and the decreased superoxid-dismutase (SOD) activity of erythrocytes and lymphocytes in patients with alcoholic liver cirrhoses. The scavanger effect of these drugs was demonstrated in the subcellular fractions of liver cells in animal experiments. The data support the therapeutic effect of these drugs in liver diseases.
Fehér
J
J
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
Cornides
A
A
Pál
J
J
Láng
I
I
Csomós
G
G
D000328:Adult; D000620:Aminoimidazole Carboxamide / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D004341:Drug Evaluation; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy* / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D051381:Rats; D012838:Silymarin / Q000009:adverse effects / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood
D005419:Flavonoids; D007093:Imidazoles; D012838:Silymarin; D000620:Aminoimidazole Carboxamide; D013482:Superoxide Dismutase