title: Hematological studies on naturally occurring substances. II. Effects of animal crude drugs on blood coagulation and fibrinolysis systems.
abstract: The effects of 112 extracts prepared from 37 kinds of animal crude drugs and a dog's filaria were investigated on the blood coagulation and fibrinolysis systems in vitro. The plasma recalcification time method was employed for the assay of blood coagulation and fibrinolytic activity was tested by the fibrin plate method. It was found that the water extracts of Bombyx Batryticatus, Carpio Fel and Holotrichiae Vermiculus showed potent inhibitory effects on blood coagulation. The methanol extracts of Phocae Thstis et Penis, Scorpion and Tabanus were promotive effect, on the other hand. As regards the fibrinolysis system, the water extracts of Agkistrodon, Lumbricus, Hirudo, Scolopendra and Scorpion and the methanol extract of Hirudo showed a remarkable activity.
authors.forename: J D
authors.initials: JD
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Narui
authors.forename: H
authors.initials: H
authors.lastname: Kurata
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Okuyama
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits
chemical_list: D004365:Drugs, Chinese Herbal