Pharmacological studies on the central action of novel benzylidene-imidazothiazolone derivatives.
Pharmacological studies on the central action of novel benzylidene-imidazothiazolone derivatives were carried out on mice and rats. The highest activity showed two compounds: a chloro- and a methoxy- derivative. They produced analgesic, anticonvulsant, anti-anxiety and "antidepressant" effects in mice.
Kolasa
K
K
Department of Pharmacology, Medical Academy, Lublin, Poland.
Kleinrok
Z
Z
Pietrasiewicz
T
T
Czechowska
G
G
Kieć-Kononowicz
K
K
Zejc
A
A
D000700:Analgesics; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000494:pharmacology*
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007093:Imidazoles; D013844:Thiazoles; D012110:Reserpine; D006220:Haloperidol; D001058:Apomorphine