title: P-fimbriae vaccines. II. Cross reactive protection against pyelonephritis.
abstract: Protection against acute pyelonephritis was induced by immunization of baboons with purified P-fimbriae of Escherichia coli as vaccines. To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with P-fimbriae purified from either E. coli strain ER2 or strain JR1 and subsequently challenged the animals with E. coli strain JR1. All vaccinated animals showed elevated antibody titers to P-fimbriae from both of the E. coli strains used. Both vaccines tended to reduce the time of bacteriuria. They partially prevented pyelonephritis and protected against loss of renal function.
authors.affiliation: Department of Urology, Delta Regional Primate Research Center, Covington, LA 70433.
authors.forename: J A
authors.initials: JA
authors.lastname: Roberts
authors.forename: M B
authors.initials: MB
authors.lastname: Kaack
authors.forename: G
authors.initials: G
authors.lastname: Baskin
authors.forename: T K
authors.initials: TK
authors.lastname: Korhonen
authors.forename: S B
authors.initials: SB
authors.lastname: Svenson
authors.forename: J
authors.initials: J
authors.lastname: Winberg
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003429:Cross Reactions; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000517:prevention & control*; D010861:Fimbriae, Bacterial / Q000276:immunology*; D010215:Papio; D011704:Pyelonephritis / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines