title: Amplification of the antitumor activity of phleomycins and bleomycins in rats and mice by caffeine.
abstract: While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleomycin below the minimum effective level. Positive but less conclusive results were also obtained with PLM-A4A4G and PLM-G.
authors.forename: T E
authors.initials: TE
authors.lastname: Allen
authors.forename: N A
authors.initials: NA
authors.lastname: Aliano
authors.forename: R J
authors.initials: RJ
authors.lastname: Cowan
authors.forename: G W
authors.initials: GW
authors.lastname: Grigg
authors.forename: N K
authors.initials: NK
authors.lastname: Hart
authors.forename: J A
authors.initials: JA
authors.lastname: Lamberton
authors.forename: A
authors.initials: A
authors.lastname: Lane
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D002110:Caffeine / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010692:Phleomycins / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010692:Phleomycins; D001761:Bleomycin; D002110:Caffeine; D004247:DNA