Host genetic regulation of acute MHV-4 viral encephalomyelitis and acute experimental autoimmune encephalomyelitis in (BALB/cKe x SJL/J) recombinant-inbred mice.
In the present report we provide the strain distribution patterns of susceptibility to acute mouse hepatitis virus type-4 (MHV-4) encephalomyelitis, acute experimental allergic encephalomyelitis (EAE) and vasoactive amine sensitivity (VAAS) for 9 (CXJ) recombinant-inbred strains between BALB/cKe (C) and SJL/J(J) mice. We confirm that susceptibility to MHV-4 is not linked to the H-2 complex, and that all strains susceptible to acute EAE have both a responder H-2 haplotype (H-2s or H-2d) and induced (B. pertussis) VAAS. In addition, we provide evidence that susceptibility to acute EAE induction is controlled by an additional presently unmapped locus and that an EAE-like histopathological disease does not usually follow MHV-4 infection intracerebrally in animals susceptible to MHV-4, acute EAE and induced VAAS.
Knobler
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RL
Linthicum
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Cohn
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D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology; D004679:Encephalomyelitis / Q000235:genetics* / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006238:Haploidy; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000276:immunology; D006632:Histamine / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats
D006183:H-2 Antigens; D004676:Myelin Basic Protein; D006632:Histamine