Alterations in rat mineral metabolism induced by acute ammonium acetate infusion.
1. Acute ammonium intoxication in rat was produced by an i.v. overload of 1000 nmoles of ammonium acetate infunded during 15 min. 2. The load of ammonium produced sodium and potassium accumulation in muscle and plasma, minor in liver, and decreased these metal levels in kidney. 3. Blood and muscle magnesium content was strongly altered as a result of ammonium intoxication. 4. Calcium plasma levels, iron blood levels and iron hepatic stock diminished after the ammonium infusion. 5. Copper and zinc homeostasis were insignificantly altered.
Bladé
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Departament d'Enginyeria Química i Bioquímica, Facultat de Ciències Químiques de Tarragona, Universitat de Barcelona, Spain.
Arola
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D000085:Acetates / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008903:Minerals / Q000097:blood / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D008903:Minerals; C018824:ammonium acetate