Central temperature effects of the transmitter amino acids.
Experiments were carried out to determine the temperature changes induced by the transmitter amino acids gamma-aminobutyric acid (GABA), taurine and glycine (representatives of the inhibitor class of amino acids), and of L-glutamic acid and L-aspartic acid (representatives of the excitatory functional class of amino acids). The amino acids were introduced directly into the preoptic anterial part of the hypothalamus (PO/AH). The experiments were made on male Wistar rats into which cannules were implanted in advance in PO/AH using a stereotaxic apparatus and coordinates of administration after König and Klippel. At ambient temperature of 22 degrees C GABA and taurine are found to cause a dose-dependent hypothermal response, L-aspartic acid and L-glutamic acid lead to dose-dependent hyperthermia, while glycine does not change the body temperature.
Yakimova
K
K
Department of Pharmacology and Toxicology, Research Institute of Pharmacology and Pharmacy, Medical Academy, Sofia.
Ovtcharov
R
R
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D013654:Taurine; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine