Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.
Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amiodarone had no effect, and corticosteroids were required. In addition to these patients, several cases of bronchiolitis obliterans organising pneumonia have been reported during treatment with gold salts, amiodarone, and miscellaneous other drugs. Taken together, this information supports the view that bronchiolitis obliterans organising pneumonia may be a form of response by the lungs to insult by drugs.
Camus
P
P
Service de Pneumologie et de Réanimation Respiratoire, Centre Hospitalier Universitaire, Dijon, France.
Lombard
J N
JN
Perrichon
M
M
Piard
F
F
Guérin
J C
JC
Thivolet
F B
FB
Jeannin
L
L
D000070:Acebutolol / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D001706:Biopsy; D001989:Bronchiolitis Obliterans / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology
D000070:Acebutolol; D000638:Amiodarone