title: Bopindolol in the treatment of hypertension: a double blind study comparing bopindolol and metoprolol.
abstract: The article presents the experience gained with a new betablocker- bopindolol-in the treatment of hypertension. Using a three-month double blind study conducted in 2 centres, the antihypertensive effect of bopindolol and metoprolol was compared in a total of 86 patients. The incidence of undesirable effects was determined, and biochemical parameters before and after therapy were followed up. Both drugs were equally effective in controlling blood pressure. In 70% of patients with mild and moderate hypertension, diastolic pressure values less than 95 mmHg were obtained in monotherapy with a betablocker. The incidence of undesirable effects was low, the drug was tolerated well. Biochemical parameters did not change within the three months of study.
authors.affiliation: Department of Cardiology, Postgraduate Medical and Pharmaceutical Institute, Prague, Czechoslovakia.
authors.forename: K
authors.initials: K
authors.lastname: Lefflerová
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínek
authors.forename: J
authors.initials: J
authors.lastname: Widimský
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínková
authors.forename: O
authors.initials: O
authors.lastname: Uhlír
authors.forename: P
authors.initials: P
authors.lastname: Miklis
authors.forename: K
authors.initials: K
authors.lastname: Zeman
authors.forename: J
authors.initials: J
authors.lastname: Zicha
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010869:Pindolol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D010869:Pindolol; D008790:Metoprolol; C036007:bopindolol