title: Transfer of metaclazepam and its metabolites into breast milk.
abstract: Ten young women took part in this study a few days after delivery (day 3 and day 5 post partum). Lactation had developed normally but the newborn infants were not breast-fed. The study was intended to investigate whether metaclazepam (Talis), a new 1,4-benzodiazepine, and some of its metabolites were present in breast milk. Levels were measured in the plasma and milk. The levels in the milk showed that metaclazepam, N-desmethylmetaclazepam and two of its metabolites with a lactam structure could be found in small amounts. Differences in metaclazepam and N-desmethylmetaclazepam concentrations in the breast milk on days 3 and 5 post partum are discussed.
authors.affiliation: Klinikum Hof/Saale, Fed. Rep. of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schotter
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Günther
authors.forename: H J
authors.initials: HJ
authors.lastname: Hausleiter
authors.forename: G
authors.initials: G
authors.lastname: Achtert
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D001569:Benzodiazepines / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000378:metabolism*
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; C036366:metaclazepam