Importance of the redox state in vasoconstriction induced by adrenaline and serotonin.
The actin myosin system and the redox state have been implicated in a number of cellular functions and in many pathological conditions. To study the predictions of a new redox theory of actin-myosin interaction we examined the relationship between the redox state and vasoconstriction of rat aorta and dog basilar artery by adrenaline and serotonin. The results show that the contraction induced by these physiological agents can be inhibited and reversed by reducing agents.
Papadopulos-Eleopulos
E
E
Department of Medical Physics, Royal Perth Hospital, Western Australia.
Knuckey
N W
NW
Dufty
A
A
Fox
R A
RA
D000205:Actomyosin / Q000378:metabolism*; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism; D001488:Basilar Artery / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D008297:Male; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D009124:Muscle Proteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid; D014661:Vasoconstriction / Q000187:drug effects*
D002951:Citrates; D009124:Muscle Proteins; D013386:Succinates; D019343:Citric Acid; D012701:Serotonin; D000205:Actomyosin; D019802:Succinic Acid; D005978:Glutathione; D002118:Calcium; D004837:Epinephrine; D004121:Dimethyl Sulfoxide