Microbial conversion of anthracyclinones to carminomycins by a blocked mutant of Actinomadura roseoviolacea.
New anthracycline antibiotics, 1-hydroxy-11-deoxycarminomycin II and 11-deoxycarminomycin II were produced by a blocked mutant MuW1 of Actinomadura roseoviolacea from epsilon-pyrromycinone and aklavinone, respectively. We found that the enzyme catalyzing hydroxylation at the C-11 position was not lost but was down regulated in the strain MuW1.
Nakagawa
M
M
Institute of Applied Microbiology, University of Tokyo, Japan.
Hayakawa
Y
Y
Imamura
K
K
Seto
H
H
Otake
N
N
D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D002360:Carubicin / Q000096:biosynthesis*; D002855:Chromatography, Thin Layer; D003630:Daunorubicin / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009154:Mutation; D009618:Nocardiaceae / Q000235:genetics / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D002360:Carubicin; D003630:Daunorubicin