title: Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid arthritis.
abstract: We describe 2 patients who developed reversible decompensated liver disease while taking pulse dosed methotrexate (MTX) for rheumatoid arthritis. One of the patients was available for biopsy and had chronic active hepatitis--a lesion not previously described with MTX. This appears to be a unique and unusual manifestation of MTX hepatotoxicity.
authors.affiliation: Department of Medicine, University of Utah, School of Medicine, Salt Lake City.
authors.forename: D O
authors.initials: DO
authors.lastname: Clegg
authors.forename: D E
authors.initials: DE
authors.lastname: Furst
authors.forename: K G
authors.initials: KG
authors.lastname: Tolman
authors.forename: R
authors.initials: R
authors.lastname: Pogue
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001201:Ascites / Q000139:chemically induced; D056487:Chemical and Drug Induced Liver Injury, Chronic; D005234:Fatty Liver / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D008727:Methotrexate