Photostabilization of doxorubicin hydrochloride with radioprotective and photoprotective agents: potential mechanism for enhancing chemotherapy during radiotherapy.
p-Aminobenzoic acid (PABA), urocanic acid, and sodium urate were found to significantly enhance the photostability of doxorubicin hydrochloride [adriamycin, (ADR)]. d1-Methionine, thiourea, and glycine also increased the photostability of this drug, but to a lesser degree. Sodium thiosulfate on the other hand, was found to be detrimental to the photostability of ADR. The photostabilizing effect of PABA was found to increase with increase of its concentration and was influenced by the pH and the buffer species of the vehicle. The findings would have an impact on the enhancement of therapeutic efficacy of adriamycin when administered during radiation therapy.
Habib
M J
MJ
Asker
A F
AF
D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000528:radiation effects*; D004355:Drug Stability; D008027:Light; D011837:Radiation-Protective Agents
D011837:Radiation-Protective Agents; D004317:Doxorubicin