title: Herpes simplex virus, Candida albicans and mouth ulcers in neutropenic patients with non-haematological malignancy.
abstract: Mouth ulcers are a frequent cause of morbidity in patients rendered neutropenic as a result of chemotherapy. We report here a series of 28 such patients from whom swabs were taken for viral isolation and mycological culture. In 13 patients, herpes simplex virus (type I) was isolated and in 17 patients Candida albicans was cultured. Both organisms were isolated in 9 patients. Our results suggest that both a viral and fungal element may be important in the aetiology of oral ulceration and that antiviral and antifungal agents may each have a role in the prophylaxis and treatment of such patients.
authors.affiliation: Imperial Cancer Research Fund Medical Oncology Unit, Western General Hospital, Edinburgh, Scotland, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Beattie
authors.forename: J
authors.initials: J
authors.lastname: Whelan
authors.forename: J
authors.initials: J
authors.lastname: Cassidy
authors.forename: L
authors.initials: L
authors.lastname: Milne
authors.forename: S
authors.initials: S
authors.lastname: Burns
authors.forename: R
authors.initials: R
authors.lastname: Leonard
mesh_terms: D000380:Agranulocytosis / Q000150:complications*; D000970:Antineoplastic Agents / Q000009:adverse effects; D002180:Candidiasis, Oral / Q000209:etiology*; D006801:Humans; D009059:Mouth Diseases / Q000209:etiology*; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D013283:Stomatitis, Herpetic / Q000209:etiology*; D014456:Ulcer / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents