title: Retinal patching: a new approach to the management of selected retinal breaks.
abstract: Restoration of retinal continuity by a patching technique is proposed as a new means of treating selected rhegmatogenous retinal detachments where established techniques frequently fail. The patch consists of a substrate and adhesive applied to the inner surface of the retina surrounding the retinal break. Bovine eye cup experiments have been performed to explore the effectiveness of a range of adhesives, and cyanoacrylates and Tisseel have been found to be effective. Studies of these adhesives on confluent cultures of bovine retinal pigment epithelial cells and glia revealed temporary cyanoacrylate toxicity and stimulation of proliferation by Tisseel. Substrate biocompatability was investigated by observing the growth of cells on various substrates in tissue culture; biological substrates such as lens capsule supported cell growth whereas synthetic membranes only did so if pretreated with fibronectin.
authors.affiliation: Pathology Department, Institute of Ophthalmology, London.
authors.forename: C E
authors.initials: CE
authors.lastname: Gilbert
authors.forename: I
authors.initials: I
authors.lastname: Grierson
authors.forename: D
authors.initials: D
authors.lastname: McLeod
mesh_terms: D000818:Animals; D002417:Cattle; D046508:Culture Techniques; D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive; D008422:Materials Testing; D008722:Methods; D008938:Mitosis; D012163:Retinal Detachment / Q000628:therapy; D012167:Retinal Perforations / Q000628:therapy*; D014014:Tissue Adhesives
chemical_list: D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives