A pharmacokinetic evaluation of IM administration of bleomycin oil suspension.
Bleomycin oil suspension was given IM twice daily to four patients, and bleomycin saline solution infused to three patients with cervical carcinoma. The serum levels of bleomycin were followed for 12 h by radioimmunoassay. Both regimens revealed comparable side effects. Only minor responses were seen. Bleomycin oil suspension produced prolonged levels of bleomycin in serum.
Davy
M
M
Paus
E
E
Lehne
G
G
D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D009821:Oils / Q000008:administration & dosage; D013535:Suspensions
D009821:Oils; D013535:Suspensions; D001761:Bleomycin