Cytochemistry of the tubular aggregates found in hepatocytes of interferon-treated suckling mice.
Administration of mouse interferon to neonatal mice induces the formation of tubular aggregates within hepatocytes. These aggregates are composed of networks of small tubules which are continuous with the granular endoplasmic reticulum. The tubules are bounded by trilaminar unit membranes and exhibit glucose-6-phosphatase activity. These features suggest that the tubular aggregate is an interferon-induced alteration of the endoplasmic reticulum.
Moss
J
J
Woodrow
D F
DF
Gresser
I
I
D000818:Animals; D000833:Animals, Suckling; D006651:Histocytochemistry; D007372:Interferons / Q000494:pharmacology*; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice
D007372:Interferons