title: Chromium carcinogenicity: California strategies.
abstract: Hexavalent chromium was identified by California as a toxic air contaminant (TAC) in January 1986. The California Department of Health Services (CDHS) concurred with the findings of the International Agency for Research on Cancer that there is sufficient evidence to demonstrate the carcinogenicity of chromium in both animals and humans. CDHS did not find any compelling evidence demonstrating the existence of a threshold with respect to chromium carcinogenesis. Experimental data was judged inadequate to assess potential human reproductive risks from ambient exposures. Other health effects were not expected to occur at ambient levels. The theoretically increased lifetime carcinogenic risk from a continuous lifetime exposure to hexavalent chromium fell within the range 12-146 cancer cases per nanogram hexavalent chromium per cubic meter of air per million people exposed, depending on the potency estimate used. The primary sources found to contribute significantly to the risk of exposure were chrome platers, chromic acid anodizing facilities and cooling towers utilizing hexavalent chromium as a corrosion inhibitor. Evaluation of genotoxicity data, animal studies and epidemiological studies indicates that further consideration should be given to the potential carcinogenicity of hexavalent chromium via the oral route.
authors.affiliation: California Department of Health Services, Berkeley 94704.
authors.forename: G V
authors.initials: GV
authors.lastname: Alexeeff
authors.forename: K
authors.initials: K
authors.lastname: Satin
authors.forename: P
authors.initials: P
authors.lastname: Painter
authors.forename: L
authors.initials: L
authors.lastname: Zeise
authors.forename: C
authors.initials: C
authors.lastname: Popejoy
authors.forename: G
authors.initials: G
authors.lastname: Murchison
mesh_terms: D000393:Air Pollutants / Q000633:toxicity; D000397:Air Pollution / Q000331:legislation & jurisprudence*; D002140:California; D002273:Carcinogens; D002857:Chromium / Q000633:toxicity; D004781:Environmental Exposure; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D002273:Carcinogens; D002857:Chromium