Twenty loci form a continuous linkage map of markers for human chromosome 2.
We have used a combination of 20 DNA markers and 1 protein electromorph, defining 20 loci, to construct a genetic linkage map of chromosome 2. These markers form a continuous linkage group of 306 cM in males and 529 cM in females. Female map distances varied from approximately twofold higher to equivalence from those of males across the map. Among the DNA markers are six well-distributed, highly polymorphic markers reflecting loci that contain a variable number of tandem repeats that will be highly efficient anchor points for the eventual application of this map to studies of human genetic disease.
O'Connell
P
P
Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 54132.
Lathrop
G M
GM
Nakamura
Y
Y
Leppert
M L
ML
Lalouel
J M
JM
White
R
R
D000483:Alleles; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D005819:Genetic Markers