[Changes in urinary levels of MHPG, VMA and 5-HIAA and plasma tryptophan in post-partum blues. Initial results].
In post-partum depressive illness ("post-partum blue") we measured urinary MHPG, VMA, 5-HIAA and free and total Trp. VMA and especially MHPG reflect the brain noradrenaline metabolism. Trp is the precursor of 5-HT synthesis and 5-HIAA is the main urinary catabolite of 5-HT. The clinical evaluation consisted in self-evaluation scales: Pitt scale 1, 3 and 5 days after delivery, CESD scale of NIMH (depression) and BONIS scale (anxiety) at 6th day. Moreover a psychiatrist measured depression intensity on the MADRS scale and DSM III data. First results seem to indicate a decrease of free MHPG and VMA, an increase of 5-HIAA and no alteration of free and total Trp. These modifications could involve adrenergic and serotoninergic alterations in brain.
Garnier
J P
JP
Bousquet
B
B
Dreux
C
C
Rouillon
F
F
Lepine
J P
JP
Lemperiere
T
T
D003863:Depression / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D007743:Labor, Obstetric; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood*; D014642:Vanilmandelic Acid / Q000652:urine*
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D014364:Tryptophan
Modification des taux de MHPG, VMA, 5-HIAA urinaires et de tryptophane plasmatique dans le "post-partum blue". Premiers résultats.