Effects of repeated testing on the incidence of haloperidol-induced catalepsy in mice.
Effects of repeated testing on the incidence of haloperidol-induced catalepsy were investigated in mice. The incidence of catalepsy, evaluated with the forelimbs or hindlimbs placed on a standard horizontal bar, increased in three successive tests in mice injected with haloperidol. Catalepsy was not provoked by repeated testing in animals with saline. In a subsequent study, mice were examined for catalepsy in the forelimbs in the first two trials and then in the hindlimbs. In this procedure, the incidence of catalepsy did not increase with repeated testing. These results suggest that repeated testing increases the incidence of haloperidol-induced catalepsy but does not influence the cataleptogenic potency of the drug.
Iwata
S
S
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan.
Izumi
K
K
Shimizu
T
T
Fukuda
T
T
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D006220:Haloperidol / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D013997:Time Factors
D006220:Haloperidol