Evidence for normal thymic export of lymphocytes and an intact RT6a gene in RT6 deficient diabetes prone BB-rats.
Diabetes prone BB-rats develop an insulin-dependent diabetes mellitus between postnatal day 60 and 120 in a high incidence. Moreover, even before onset of the diabetes, these animals are deficient in the RT6+ subset of T lineage cells. We here put forward evidence that the export of cells from the thymus is normal in these rats, suggesting a maturational block in the periphery. We show furthermore by Southern blot analysis that diabetes prone BB-rats possess the RT6a gene which is not grossly altered in comparison to that of diabetes resistant strains.
Thiele
H G
HG
Abteilung für Immunologie, Universitätskrankenhaus Hamburg-Eppendorf.
Koch
F
F
Haag
F
F
Wurst
W
W
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D002465:Cell Movement; D004247:DNA / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000235:genetics / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis / Q000235:genetics*; D051381:Rats; D011913:Rats, Inbred BB; D013601:T-Lymphocytes / Q000502:physiology*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000502:physiology*
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D018800:Thy-1 Antigens; C038353:histocompatibility antigens RT, rat; D004247:DNA