title: Elimination of cefuroxime and gentamicin during and after open heart surgery.
abstract: In eight consecutive adult heart surgery patients, serum concentrations of cefuroxime and gentamicin were studied during and after operation. Repeated doses of cefuroxime 1.5 g and gentamicin 80 mg were given. Intra-operative concentrations were deemed adequate (cefuroxime Cmin: 16-45 mg/l, gentamicin Cmin: 1.6-2.8 mg/l), and no differences (P = 0.05) could be demonstrated between elimination rates during and after open heart operation (cefuroxime T1/2 101 vs 111 min, gentamicin T1/2 191 vs 193 min).
authors.affiliation: Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Lippert
authors.forename: S D
authors.initials: SD
authors.lastname: Josephsen
authors.forename: M
authors.initials: M
authors.lastname: Jendresen
authors.forename: T S
authors.initials: TS
authors.lastname: Sørensen
authors.forename: E
authors.initials: E
authors.lastname: Gutschik
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002444:Cefuroxime / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002511:Cephalosporins / Q000493:pharmacokinetics*; D005260:Female; D005839:Gentamicins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011292:Premedication
chemical_list: D002511:Cephalosporins; D005839:Gentamicins; D002444:Cefuroxime