title: Drawbacks of selection methods for synchronous cell growth: simulation techniques.
abstract: Investigations of Koch & Schaecter's (1962) model for the fission of a bacterium were carried out to resolve some conflict in the findings due to Takahasi et al. (1968) and Marr et al. (1969). A computer simulation procedure was used to reexamine the work of Takahasi et al. Our results confirm their findings that a simple formulation of Koch & Schaecter's model predicts a synchronous growth curve which fits the data reasonably well. This contrasts with the predictions of a poor fit given by the complex formulations of Marr et al. However, there is a disagreement between our results and those obtained by Takahasi et al. It involves a relationship between independence of the life length of daughter and mother cells and the degree of synchrony in growth. The practical implications of the simulation results are that selection methods are unlikely to give perfect synchrony.
authors.affiliation: Department of Computer Studies and Mathematics, Bristol Polytechnic, UK.
authors.forename: H K
authors.initials: HK
authors.lastname: Chadha-Boreham
authors.forename: N
authors.initials: N
authors.lastname: Westwood
mesh_terms: D001419:Bacteria / Q000254:growth & development*; D002453:Cell Cycle; D002455:Cell Division; D003198:Computer Simulation; D007700:Kinetics; D008962:Models, Theoretical; D013997:Time Factors