title: The effect of caffeine ingestion on physical performance after prolonged exercise.
abstract: The purpose of this study was to determine the effect of caffeine ingestion on physical performance after prolonged endurance exercise. Twenty three trained male volunteers participated in a 40-km march and were divided into two groups, matched for caffeine clearance rate and aerobic capacity. The experimental group ingested, prior to the march, a caffeinated drink at a dose of 5 mg.kg-1 body mass and at the 3rd and 5th h of marching an additional drink at a dose of 2.5 mg.kg-1 body mass. The control group ingested a drink of equal volume at the same times. Upon termination of the march each subject performed a cycle ergometer test at an intensity of 90% maximal oxygen consumption. Time to exhaustion and rate of perceived exertion (RPE) were recorded. Blood samples were drawn predrink, at the 3rd and 5th h of marching and immediately after the cycle ergometer test, and were analysed for caffeine, free fatty acids (FFA), lactate and glucose levels. Plasma FFA levels increased during the march (p less than 0.05), with no significant difference between groups. Lactate levels increased in the experimental group (p less than 0.05), with no significant change in the control group. Glucose levels did not change significantly in either group. After the cycle ergometer test, lactate levels were significantly higher in the experimental, as compared to the control group (3.77 +/- 0.33 vs 2.52 +/- 0.35 mmol.l-1, respectively). There was no significant difference between treatments in the time to exhaustion on the cycle ergometer, but RPE was different (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Falk
authors.forename: R
authors.initials: R
authors.lastname: Burstein
authors.forename: I
authors.initials: I
authors.lastname: Ashkenazi
authors.forename: O
authors.initials: O
authors.lastname: Spilberg
authors.forename: J
authors.initials: J
authors.lastname: Alter
authors.forename: E
authors.initials: E
authors.lastname: Zylber-Katz
authors.forename: A
authors.initials: A
authors.lastname: Rubinstein
authors.forename: N
authors.initials: N
authors.lastname: Bashan
authors.forename: Y
authors.initials: Y
authors.lastname: Shapiro
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002110:Caffeine / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004311:Double-Blind Method; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007773:Lactates / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption; D005082:Physical Exertion / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006454:Hemoglobins; D007773:Lactates; D002110:Caffeine