Pharmacological manipulations of sucrose consumption in the Syrian hamster.
Nondeprived, male Syrian hamsters (Mesocricetus auratus) were adapted to a daily schedule of 2-hr access to a 10% sucrose solution. Two benzodiazepines, midazolam (1.0-10 mg/kg) and flurazepam (1.0-10 mg/kg), produced dose-dependent increases in sucrose consumption. In contrast, the alpha 2-adrenergic agonist, clonidine (0.01-0.3 mg/kg), had no effect on sucrose intake. Neither d-fenfluramine nor d-amphetamine affected sucrose ingestion in the hamsters, except at a large dose (10 mg/kg). Nevertheless, significant, dose-dependent reductions in sucrose consumption were observed after the administration of either opiate antagonists (naltrexone; nalmefene) or selective dopamine D2 receptor agonists (N-0437; quinpirole). The results are compared and contrasted with previously reported data for rats.
Cooper
S J
SJ
School of Psychology, University of Birmingham, U.K.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D006224:Cricetinae / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus / Q000502:physiology*; D013395:Sucrose / Q000008:administration & dosage*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology
D013764:Tetrahydronaphthalenes; D013876:Thiophenes; D001569:Benzodiazepines; D005277:Fenfluramine; D013395:Sucrose; C047508:rotigotine; D000661:Amphetamine; D003000:Clonidine