Synthesis of procaterol derivative having a piperidylmethanol group and its beta-adrenoceptor stimulant activities.
A procaterol derivative (6) having a piperidylmethanol group was synthesized by the nucleophilic reaction of a 5-formylcarbostyril derivative with pyridyllithium, followed by selective catalytic reductions to afford the erythro-isomer. Compound 6 showed non-selective beta-adrenoceptor agonist activities like those of l-isoproterenol in an in vivo assay using anesthetized dogs.
Yoshizaki
S
S
Tamada
S
S
Umezato
M
M
Yabuuchi
Y
Y
D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000138:chemical synthesis*; D017265:Procaterol
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D010880:Piperidines; D017265:Procaterol