title: Effect of antacid treatment on endogenous prostaglandin synthesis in human antral and duodenal mucosa.
abstract: Using 14C-labeled arachidonic acid as precursor for in vitro prostaglandin synthesis, the effect of an antacid containing Al (OH)3, Mg(OH)2 and CaCO3 on endogenous prostaglandin synthesis was investigated in antral and duodenal mucosa of healthy volunteers. After three weeks of treatment with a high-dose antacid, there was no detectable change in the total capacity of the mucosa for prostaglandin synthesis, but the prostaglandin profile was markedly altered. The relative amounts of PGE2 and PGF2 alpha synthesized by antral and duodenal mucosa increased at the expense of the prostaglandins A2/B2, thromboxane A2, and prostacyclin. In a short-term study, this change was not observed following a single antacid dose within 1 hr after application. It is concluded that long-term antacid treatment may alter the prostaglandin pattern formed by gastroduodenal mucosa and this may be related to its therapeutic effect.
authors.affiliation: University of Ulm, Department of Internal Medicine II, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Preclik
authors.forename: E F
authors.initials: EF
authors.lastname: Stange
authors.forename: K
authors.initials: K
authors.lastname: Gerber
authors.forename: G
authors.initials: G
authors.lastname: Fetzer
authors.forename: H
authors.initials: H
authors.lastname: Horn
authors.forename: A
authors.initials: A
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Ditschuneit
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000494:pharmacology*; D015237:Dinoprost / Q000096:biosynthesis; D015232:Dinoprostone / Q000096:biosynthesis; D004338:Drug Combinations / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011706:Pyloric Antrum / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000863:Antacids; D004338:Drug Combinations; D011453:Prostaglandins; C007565:aluminum hydroxide, calcium carbonate, magnesium hydroxide drug combination; D000536:Aluminum Hydroxide; D015237:Dinoprost; D002119:Calcium Carbonate; D008274:Magnesium; D015232:Dinoprostone; D008276:Magnesium Hydroxide