title: [Extending the survival time of allogenic heart and kidney transplants in the rat by a combination of PUVA transplant conditioning and cyclosporin treatment of the recipient].
abstract: Dose-response studies of cyclosporin (CsA) established that a dose of 2 mg kg body weight on day 0 was of therapeutic suboptimal value in rat kidney allotransplantation. When PUVA-treated heart and kidney allografts were transplanted into temporary CsA immunosuppressed recipients the graft survival rates were further improved as compared with PUVA alone. Forty vs. 18% (heart) and 70 vs. 40% (kidney) of the PUVA + CsA vs. PUVA treated allografts survived permanently. Therefore a synergistic effect of PUVA pretreatment and low-dose CsA therapy on rat heart and renal allograft survival was demonstrated.
authors.affiliation: Klinik für Urologie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
authors.forename: H
authors.initials: H
authors.lastname: Oesterwitz
authors.forename: J
authors.initials: J
authors.lastname: Kaden
authors.forename: W
authors.initials: W
authors.lastname: Schneider
authors.forename: R
authors.initials: R
authors.lastname: Schirrow
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D016030:Kidney Transplantation; D008297:Male; D011701:PUVA Therapy; D011292:Premedication; D051381:Rats
chemical_list: D003524:Cyclosporins
vernacular_title: Verlängerung der Uberlebenszeit allogener Herz- und Nierentransplantate bei der Ratte durch eine Kombination von PUVA-Transplantatkonditionierung und Cyclosporin-Empfängerbehandlung.