Effect of DDE on ionic and fluid movement in rat colon in vitro.
1. The effect of DDE on ionic (Na+ and K+) and fluid movement was studied in rat colon in vitro. 2. DDE (10(-7) M) increased net K+ secretion while inhibited the net flux of Na+ and fluid movement inducing net secretion. 3. DDE added before or after aldosterone caused an inhibition on the net influx of Na+ and fluid movement and potassium secretion. 4. DDE also inhibited (Na+ and K+)-ATPase from the same tissue suggesting that the inhibition of DDE is due to an action of this organochlorine compound on the sodium pump.
Iturri
S J
SJ
Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Santiago.
Zamorano
B
B
Peña
A
A
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D001826:Body Fluids / Q000187:drug effects*; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D003633:Dichlorodiphenyl Dichloroethylene / Q000633:toxicity*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000450:Aldosterone; D003633:Dichlorodiphenyl Dichloroethylene; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium