Structure and function of P-glycoprotein.
P-glycoprotein remains the best understood molecule that has been implicated in the multidrug resistance phenomenon. As I have attempted to show, our understanding of this molecule is still in its infancy, with many questions as yet unanswered. It is anticipated that the answers to these questions will contribute to our understanding of drug resistance, as it relates to cancer, and also to our understanding of what appears to be a fundamental transport system.
Gerlach
J H
JH
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D004351:Drug Resistance; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins