[Experimental studies on the relation of the kidney and reproduction].
To elucidate the mechanism of TCM in treating polycystic ovary syndrome, the authors tried to produce experimental PCO by sterilizing Kunming mice with 1 mg testosterone in various ages of day (5, 8, 11, 14, 17, 21 days). Every litter consisting of 10 young mice was divided into two groups: testosterone given group (T) and control group (C). At the age of 72-75 day, ovaries and uteri were weighed and all ovaries were investigated histologically. Mating was attempted in the two groups. 19 of the 20 ovaries in T5 group, but none of the other groups showed polycystic features. 4 of the 15 mice in T5 group and all of the other groups resulted in pregnancy (P less than 0.05). It was suggested that polycystic ovary was formed in the Kunming mice at age of less than 5 days administered with testosterone. For observation of tonifying Kidney drugs on the ovaries and uteri of the polycystic ovary model in Kunming mice, testosterone was given to Kunming mice of various age (2, 5, 8, 11, 14 days). The tonifying Kidney drugs for anovulatory menstrual disorder were separated into two parts, water soluble part(MS) and ester soluble part (ML). At the age of 56 days (8 weeks), two parts of the drug were given for 14 days to every group of the mice respectively. One day after the administration, uteri were weighed, ovaries were investigated microscopically, and mating was attempted in both groups. All uteri in mice taken water soluble drugs(MS) increased in weight (P less than 0.05), but not in the ML groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Yu
J
J
Cheng
H Y
HY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007668:Kidney / Q000502:physiology*; D008516:Medicine, Chinese Traditional; D051379:Mice; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000188:drug therapy; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D013739:Testosterone
D004365:Drugs, Chinese Herbal; D013739:Testosterone