title: Dermatitis of the face, yellow toe nail changes, hairy leukoplakia and oral candidiasis are clinical indicators of progression to AIDS/opportunistic infection in patients with HIV infection.
abstract: In a prospective longitudinal study of 89 men with HIV infection and persistent generalized lymphadenopathy (PGL) we tried to find clinical signs predictive of development to AIDS/opportunistic infection (OI). The mean observation time was 47 months. 27 patients (30%) developed AIDS/OI after a mean of 37 months. The estimated median time from diagnosis of PGL to AIDS/OI was 68 months. Four clinical signs of progression towards AIDS/OI were identified: dermatitis of the face, yellow toe nail changes, hairy leukoplakia and oral candidiasis. One or more of these signs were recorded in 25/27 (93%) of the patients before the development of AIDS/OI. The estimated median time from registration of each sign to AIDS/OI was: dermatitis of the face, 29 months; yellow toe nail changes, 21 months; hairy leukoplakia, 18 months; and oral candidiasis, 10 months. The estimated median time from herpes zoster to AIDS was only slightly shorter than the estimated time from diagnosis of PGL to AIDS/OI.
authors.affiliation: Department of Infectious Diseases, Roslagstull Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Morfeldt-Månson
authors.forename: I
authors.initials: I
authors.lastname: Julander
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D002180:Candidiasis, Oral / Q000150:complications; D005148:Facial Dermatoses / Q000150:complications; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007972:Leukoplakia, Oral / Q000150:complications; D008137:Longitudinal Studies; D008297:Male; D009260:Nail Diseases / Q000150:complications; D009894:Opportunistic Infections / Q000150:complications*; D011446:Prospective Studies