title: [Cold dysmenorrhea with blood stagnation treated with zhuyu wengong decoction].
abstract: Sixty-six women with stagnant blood and cold dysmenorrhea were treated with Zhuyu Wengong Decoction (ZWD). The results showed that 47 of them were cured, 13 improved, the total effective rate was 90.9%. Before treatment, the value of amplitude and the volume of blood flow in the left pelvic cavity with blood flow graph was very lower in the dysmenorrhea patients than those in the normal women (P less than 0.01), while the number of amplitude difference between the left and the right pelvic cavity being over 30% and of abnormal wave was higher in the patients than that in the normal women (P less than 0.01). After treatment, the value of amplitude and the volume of blood flow in the left pelvic cavity had a marked increase (P less than 0.01). These data suggested that blood circulation in the pelvic cavity took a turn for the better after the treatment. The results in animal experiment also showed that ZWD had strongly suppressive effect on the automatic action of uterine muscle of rats in vitro and of rabbits in vivo. The suppressive rates were 30.75% and 20% respectively, and the contractive range was at a lower level. The decoction also had strong suppressive effect on the contract induced by MPGF2 alpha, suppressive rate decreased to 24.4% and 34.75% respectively in contrast to the group which patients had not taken this decoction. The results in this study also proved that ZWD could improve the reduction of blood flow volume induced by MPGF2 alpha and had analgesic effect on dysmenorrhea model of rats induced by oxytocin.
authors.forename: R
authors.initials: R
authors.lastname: Wu
authors.forename: T Y
authors.initials: TY
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008516:Medicine, Chinese Traditional; D010388:Pelvis / Q000098:blood supply; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow; D014599:Uterus / Q000098:blood supply / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal