Brain-specific expression of transthyretin mRNA as revealed by cDNA cloning from brain.
cDNAs for rat transthyretin mRNA were cloned from a brain cDNA library. Sequencing analyses showed the presence of an additional 5' sequence that had not been reported for the liver mRNA corresponding to the flanking promoter region of the gene. This additional sequence was expressed only in the brain, suggesting the presence of a brain-specific promoter.
Motojima
K
K
Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Goto
S
S
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D015870:Gene Expression; D015723:Gene Library; D005801:Genes, Homeobox; D011228:Prealbumin / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats
D011228:Prealbumin; D012333:RNA, Messenger; D004247:DNA