title: Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
abstract: Debrisoquine and S-mephenytoin hydroxylation phenotyping tests were performed in 9 patients before and during treatment with diazepam at a daily dose of 10 or 15 mg. There was no change in either the debrisoquine/4-hydroxydebrisoquine ratio or the ratio of S/R mephenytoin in urine. The hydroxylation of these two test drugs is apparently not inhibited by administration of therapeutic doses of diazepam.
authors.affiliation: Institute of Pharmacology, University of Messina, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Spina
authors.forename: A L
authors.initials: AL
authors.lastname: Buemi
authors.forename: E
authors.initials: E
authors.lastname: Sanz
authors.forename: L
authors.initials: L
authors.lastname: Bertilsson
mesh_terms: D000328:Adult; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D006827:Hydantoins / Q000378:metabolism*; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008617:Mephenytoin / Q000378:metabolism*; D008875:Middle Aged; D010641:Phenotype
chemical_list: D006827:Hydantoins; D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003975:Diazepam; D008617:Mephenytoin; D003647:Debrisoquin