title: Hypothermia protects brain function in acute carbon monoxide poisoning.
abstract: The role of body temperature in the morbidity and mortality resulting from acute severe carbon monoxide (CO) poisoning (2400 ppm CO, 90 min) was investigated using an unanesthetized animal model. Modified Levine prepared female rats (left common carotid artery and jugular cannulated) displayed a lower rate of recovery period (4 hr) re-warming, and an increased mortality rate and behaviorally-assessed neurologic index (NI) compared to normal rats. This indicated their greater susceptibility to CO hypoxia, although the degree of CO-induced hypothermia was the same in both groups. The whole-body cooling of Levine rats to a similar extent prior to CO exposure increased somewhat the post-CO re-warming rate, and marginally decreased NI and mortality during CO exposure (in-CO). In contrast, maintenance of constant body temperature by external heating during CO exposure resulted in a negative post-CO re-warming rate and sharply increased NI and in-CO mortality. Normal euthermic rats were much less severely affected by CO. The results suggest that hypothermia, whether CO-induced or produced by prior cooling, provides measurable protection of brain function during acute severe CO poisoning, and that maintenance of body temperature increases in-CO mortality and interferes with ability to thermoregulate and increases NI in survivors.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201.
authors.forename: B
authors.initials: B
authors.lastname: Sutariya
authors.forename: D
authors.initials: D
authors.lastname: Penney
authors.forename: J
authors.initials: J
authors.lastname: Barnes
authors.forename: C
authors.initials: C
authors.lastname: Helfman
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D002249:Carbon Monoxide Poisoning; D004195:Disease Models, Animal; D005260:Female; D006339:Heart Rate; D007035:Hypothermia / Q000401:mortality; D009017:Morbidity; D051381:Rats; D011919:Rats, Inbred Strains