Effects of 2-amino-7-phosphonoheptanoic acid on EEG of rats.
2-APH is an antagonist of excitation due to dicarboxylic amino acids and has a protective effect against several types of experimental seizures. We have studied its effect on EEG of rats. Following either intracerebroventricular or intraperitoneal administration of 2-APH produces slow waves of high voltage in central cortex. The anticonvulsant action of this drug may be related to altered activity in neurones of this area.
Rostain
J C
JC
Wardley-Smith
B
B
Meldrum
B S
BS
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography; D004594:Electrophysiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid