title: Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart.
abstract: Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was marginally reduced by the antacid.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Barzaghi
authors.forename: F
authors.initials: F
authors.lastname: Crema
authors.forename: G
authors.initials: G
authors.lastname: Mescoli
authors.forename: E
authors.initials: E
authors.lastname: Perucca
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D000863:Antacids / Q000008:administration & dosage*; D001682:Biological Availability; D002927:Cimetidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage* / Q000494:pharmacology; D012841:Simethicone / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000863:Antacids; D004338:Drug Combinations; C008570:aluminum hydroxide, magnesium hydroxide, simethicone drug combination; D000536:Aluminum Hydroxide; D002927:Cimetidine; D012841:Simethicone; D008787:Metoclopramide; D008276:Magnesium Hydroxide