Inhibitory effect of peptide YY on gastric acid output in rats.
The administration of peptide YY (PYY: 0.8, 1.6 and 3.2 nmol/kg/h, i.v.) to fasting rats inhibited not only baclofen (2 mg/kg, s.c.)-stimulated gastric acid output and gastric mucosal blood flow, but also pentagastrin (8 micrograms/kg/h, i.v.)-stimulated gastric acid output. PYY (3.2 nmol/kg/h) reduced baclofen-induced acid output more than pentagastrin-induced acid output, i.e., by 61.8 +/- 11.5% compared to 35.3 +/- 8.2%. PYY inhibited acetylcholine (ACh) release from cholinergic nerve endings of gastric body evoked by electrical transmural stimulation (ETS: 1 msec, 10 V, 3 Hz, 30 sec) by 47.2 +/- 3.5%. The mechanism of the inhibitory effect of PYY on gastric acid output seems to involve decreased gastric mucosal blood flow and reduced ACh release from cholinergic nerves.
Hashimoto
Y
Y
First Department of Surgery, Kobe University School of Medicine, Japan.
Sano
I
I
Nagahata
Y
Y
Wang
Z T
ZT
Itoh
A
A
Takeda
K
K
Ichihara
T
T
Moritomo
H
H
Urakawa
T
T
Saitoh
Y
Y
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply; D005768:Gastrointestinal Hormones / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019894:Peptide YY; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D005768:Gastrointestinal Hormones; D010455:Peptides; D019894:Peptide YY; D010418:Pentagastrin