title: Retinoblastoma. Analysis of 75 cases and proposal for a new model of oncogenesis and tumor growth kinetics.
abstract: A series of 75 retinoblastoma patients were analyzed at the Institute of Ophthalmology, Siena, and a mathematical model for the 'nodule to cancer' transformation applied to it. The authors obtained data in disagreement with Knudson's 'two hit' hypothesis but fitting an alternative model of oncogenesis. This model is based on probabilistic arguments and a possible pattern of tumor growth and evolution is given in detail.
authors.affiliation: Centro Ricerche Sclavo, Siena, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Mastrangelo
authors.forename: F
authors.initials: F
authors.lastname: Di Pisa
authors.forename: T
authors.initials: T
authors.lastname: Hadjistilianou
authors.forename: A M
authors.initials: AM
authors.lastname: Bardelli
authors.forename: S
authors.initials: S
authors.lastname: Silvestri
authors.forename: R
authors.initials: R
authors.lastname: Frezzotti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000145:classification / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D015233:Models, Statistical; D012175:Retinoblastoma / Q000145:classification / Q000209:etiology* / Q000235:genetics