The role of glutathione in the induction of hepatic gamma-glutamyltransferase by phenobarbitone.
The effect of hepatic glutathione concentration on the induction of gamma-glutamyltransferase (GGT) activity by phenobarbitone was investigated. A single dose of phenobarbitone 100 mg/kg weight was given to rats, and the concentration of hepatic glutathione and GGT activity were measured. The study results show a sharp drop of hepatic glutathione concentration within a few hours of injection. This drop precedes the increase in enzyme activity.
Braide
S A
SA
Department of Pathology, University of Leicester, UK.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D005723:gamma-Glutamyltransferase; D005978:Glutathione; D010634:Phenobarbital