title: Integration of the transabdominal technique into an ongoing chorionic villus sampling program.
abstract: Data are presented on 869 patients undergoing chorionic villus sampling procedures by one of two sampling techniques: 544 by a transcervical catheter aspiration method and 325 by a transabdominal two-needle aspiration method. The transcervical approach was the only procedure used in the first 330 cases, at which time the transabdominal technique was incorporated into our program. After an initial learning curve in the first 100 procedures the transcervical fetal loss rate stabilized at 2.7%, the number of patients requiring more than one catheter insertion decreased to 11%, and tissue weights greater than or equal to 10 mg were obtained in 88% of cases. The fetal loss rate for transabdominal chorionic villus sampling was 2.6%, indicating the addition of this new method did not significantly alter the fetal loss rate. Transabdominal chorionic villus sampling had an overall success rate of 99%, with only one insertion of the guide needle required for 98% of patients. Tissue weights of greater than or equal to 10 mg were obtained in 99% of cases. These results demonstrate that the transabdominal procedure can be rapidly and effectively incorporated by an operator already experienced with transcervical chorionic villus sampling. Since several contraindications exist for either chorionic villus sampling method, the availability of both techniques at a single center greatly enhances the ability to offer first-trimester fetal diagnosis to a majority of patients.
authors.affiliation: Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
authors.forename: K L
authors.initials: KL
authors.lastname: Copeland
authors.forename: R J
authors.initials: RJ
authors.lastname: Carpenter
authors.forename: K R
authors.initials: KR
authors.lastname: Fenolio
authors.forename: D H
authors.initials: DH
authors.lastname: Ledbetter
mesh_terms: D000005:Abdomen; D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000379:methods*; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome