Correlation between the effects of rT3 and IMP dehydrogenase inhibitors on normal and trisomic 21 lymphocyte cultures.
3,3'5'-triiodothyronine (rT3) levels have been documented to be low in patients with Down syndrome but the metabolic implications of this finding remain unknown. A highly significant correlation was found between the in vitro variations of the mitotic index in lymphocyte cultures when rT3 or known inhibitors of inosine monophosphate dehydrogenase: mycophenolic acid, 6-mercaptopurine or 2-3-diphosphoglycerate were added. No significant difference was found between the response of trisomy 21 or normal lymphocytes. The finding suggests that rT3 may be a physiological modulator of inosine monophosphate dehydrogenase. The implications on cellular differentiation are discussed.
Peeters
M
M
Centre de Recherches Génétique Humaine et Maladies de l'Intelligence,Institut de Progenèse, Paris.
Réthoré
M O
MO
de Kermadec
S
S
Lejeune
J
J
D019794:2,3-Diphosphoglycerate; D002478:Cells, Cultured; D004163:Diphosphoglyceric Acids / Q000494:pharmacology; D004314:Down Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors*; D015122:Mercaptopurine / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects*; D009173:Mycophenolic Acid / Q000494:pharmacology; D014285:Triiodothyronine, Reverse / Q000494:pharmacology*
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D014285:Triiodothyronine, Reverse; D015122:Mercaptopurine; D007168:IMP Dehydrogenase; D007658:Ketone Oxidoreductases; D009173:Mycophenolic Acid