Depressed monocyte production of interleukin-1 and tumor necrosis factor-alpha in patients with alcoholic liver cirrhosis.
Interleukin-1 and tumor necrosis factor-alpha activity by E. coli lipopolysaccharide-triggered monocytes were studied in patients with chronic alcoholic liver disease. Monocytes from cirrhotic patients were shown to have a significant reduction in IL-1 and TNF-a activity, compared with that from age- and sex-matched healthy controls. These findings indicate further immunoregulatory disturbances concerning alcoholic liver cirrhosis.
Müzes
G
G
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
Deák
G
G
Láng
I
I
González-Cabello
R
R
Gergely
P
P
Fehér
J
J
D000328:Adult; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha