The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles.
Chronic dosing studies in normal volunteers have shown that both nifedipine and diltiazem exert a small effect on serum theophylline concentrations, which tend to be higher during concurrent nifedipine therapy. The differences were not significant but may be of clinical interest as theophylline causes adverse effects at higher plasma concentrations.
Smith
S R
SR
Department of Pharmacology, Medical School, Edgbaston, Birmingham, U.K.
Haffner
C A
CA
Kendall
M J
MJ
D000328:Adult; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D016037:Single-Blind Method; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D013806:Theophylline; D004110:Diltiazem; D009543:Nifedipine