Pathophysiology of the immune system in elderly subjects with or without diabetes and variations after recombinant interleukin-2.
This study reports two groups of elderly diabetic patients and normal subjects, with or without hypercholesterolemia and hypertriglyceridemia, who presented a decrease of the T lymphocyte-mediated function, proliferative capacity, phagocytosis, cytotoxicity and surface markers. This fall was more evident in hypercholesterolemic and hypertriglyceridemic subjects. The humoral responses and other parameters studied did not reveal significant variations. The authors also observed that recombinant interleukin-2 (rIL-2) stimulation determined a satisfactory response in healthy and diabetic subjects, while it did not normalize values in patients with altered lipid balance.
Carnazzo
G
G
Department of Gerontology and Geriatric Medicine, University of Catania, Italy.
Mirone
G
G
Turturici
A
A
Favetta
A
A
Campo
M E
ME
Cosenza
C
C
Chiarenza
G
G
Stivala
F
F
D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D006937:Hypercholesterolemia / Q000276:immunology; D015228:Hypertriglyceridemia / Q000276:immunology; D007107:Immune System / Q000187:drug effects* / Q000503:physiopathology; D007376:Interleukin-2 / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D007376:Interleukin-2; D011994:Recombinant Proteins