[Assessment of potential epidemiologic danger of sources of respiratory syncytial infection by biological properties of the pathogen].
Biological properties of 188 strains of respiratory syncytial (RS) virus isolated from 93 institutionalized children during 4 years of observations were correlated with the form and stage of the infectious process, frequency of ARD, and blood group of the children for the evaluation of the epidemiological hazard of sources of RS infection. The degree of virulence of a strain was evaluated by its yields in human embryo lung culture and sensitivity to antibodies (avidity). In clinically manifest forms of RS infection more virulent strains were isolated than in inapparent infections and transitory asymptomatic virus-carrier state. Among the strains derived from children with frequent ARD, highly and moderately virulent strains were prevalent (in 72.7% high and moderate yields in cell culture, and 94.2% low avidity to antibodies) whereas children with rare ARD yielded mainly low virulent strains (70% none or low yields, and 62.5%--highly sensitive to antibodies). The RS virus strains isolated from children with A (II) blood group were found to be less sensitive to antibodies.
Karpova
L S
LS
Iurlova
T I
TI
Popova
T L
TL
Karpukhin
G I
GI
D001789:Blood Group Antigens; D002478:Cells, Cultured; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification* / Q000472:pathogenicity; D010253:Respirovirus Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D014774:Virulence
D001789:Blood Group Antigens
Otsenka potentsial'noĭ épidemiologicheskoĭ opasnosti istochnikov respiratorno-sintsitial'noĭ infektsii po biologicheskim svoĭstvam vozbuditelia.