title: Pharmacokinetics and pharmacodynamics of terguride following intramuscular administration in cows and goats.
abstract: The pharmacokinetics of intramuscular terguride (transdihydrolisuride) was evaluated in a single-dose study in cows (doses 100, 62 and 31 micrograms/kg b.w.) and goats (dose 100 micrograms/kg b.w.). A radioreceptor assay was used to quantitative plasma terguride concentrations. The peak plasma concentrations of terguride were attained within 0.6 h of the drug administration and then decreased monoexponentially with half-life of 1.3 h (cows) and 2 h (goats). The pharmacokinetics of terguride in cows is nearly linear. Pharmacodynamics of terguride was expressed as reduction in plasma prolactin levels. Maximal decline in prolactin was observed 3-4 h following terguride administration and the effect lasted for about 24 h.
authors.affiliation: Research Institute for Pharmacy and Biochemistry, Czechoslovak Academy of Sciences, Prague.
authors.forename: R
authors.initials: R
authors.lastname: Lapka
authors.forename: P
authors.initials: P
authors.lastname: Krejci
authors.forename: J
authors.initials: J
authors.lastname: Lidický
authors.forename: M
authors.initials: M
authors.lastname: Frühaufová
authors.forename: K
authors.initials: K
authors.lastname: Rezábek
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004873:Ergolines / Q000493:pharmacokinetics*; D006041:Goats / Q000378:metabolism*; D007273:Injections, Intramuscular; D008090:Lisuride / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
chemical_list: D004873:Ergolines; C006208:dironyl; D011388:Prolactin; D008090:Lisuride