Continuous administration of 5-hydroxytryptamine alters cellular immunity in chickens.
1. 5-Hydroxytryptamine administered continuously through osmotic pumps altered the PHA wattle response and in vitro leukocyte capillary tube migration in UNH 105 chickens. 2. Administration of 100 ng/hr 5-hydroxytryptamine for 48 hr significantly suppressed the PHA wattle response. 3. In vitro leukocyte migration was significantly enhanced by 72 hr exposure to 5-hydroxytryptamine at a dose of 100 ng/hr.
McCorkle
F M
FM
Department of Biology, Central Michigan University, Mt. Pleasant 48859.
Taylor
R L
RL
D000818:Animals; D002464:Cell Migration Inhibition; D002645:Chickens / Q000276:immunology*; D003129:Comb and Wattles / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007260:Infusion Pumps; D008297:Male; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*
D010835:Phytohemagglutinins; D012701:Serotonin