title: Background, epidemiology, and impact of HIV infection in children.
abstract: There was substantial difficulty in the early years of the HIV epidemic in confirming the presence of this infection in children. Serological testing finally allowed the identification of a spectrum of clinical expressions. An understanding gradually developed about the serious central nervous system involvement in children, which is more direct and intense than that usually seen in adults. My early personal experiences in this work were described.
authors.forename: A
authors.initials: A
authors.lastname: Rubinstein
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006679:HIV Seropositivity / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D009422:Nervous System Diseases / Q000209:etiology; D009894:Opportunistic Infections / Q000209:etiology; D012307:Risk Factors; D014481:United States