title: Mucociliary clearance following tracheal resection and end-to-end anastomosis.
abstract: Mucociliary clearance is an important cleaning system of the bronchial tree. The complex transport system reacts sensitively to medicinal stimuli and inhaled substances. A disturbance causes secretion retention which encourages the development of acute and chronic pulmonary diseases. It is not yet known in which way sectional resection of the central airway effects mucociliary clearance. A large number of the surgical failures are attributable to septic complications in the area of the anastomosis. In order to study the transportation process over the anastomosis, ten dogs underwent a tracheal resection with end-to-end anastomosis, and the mucociliary activity was recorded using a bronchoscopic video-technical method. Recommencement of mucous transport was observed on the third, and transport over the anastomosis from the sixth to tenth, postoperative days. The mucociliary clearance had completely recovered on the twenty-first day in the majority of dogs. Histological examination of the anastomoses nine months postoperatively showed a flat substitute epithelium without cilia-bearing cells in all dogs. This contrasts with the quick restitution of the transport function. In case of undamaged respiratory mucosa, a good adaptation of the resection margins suffices for the mucous film to slide over the anastomosis.
authors.affiliation: Schillerhöhe Hospital, Department of Thoracic Surgery, Gerlingen/Stuttgart, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Toomes
authors.forename: A
authors.initials: A
authors.lastname: Linder
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D004285:Dogs; D009079:Mucociliary Clearance; D011184:Postoperative Period; D013997:Time Factors; D014132:Trachea / Q000502:physiology / Q000601:surgery*; D014945:Wound Healing