title: A novel series of milbemycin antibiotics from Streptomyces strain E225. I. Discovery, fermentation and anthelmintic activity.
abstract: A novel series of milbemycin antibiotics were produced by soil isolate, strain E225 which was shown to be a Streptomyces species. The antibiotics displayed anthelmintic activity against Trichostrongylus colubriformis in the gerbil. Two of the compounds, VM 44857 and VM 44866 were shown to be potent anthelmintics against mixed nematode infections in sheep.
authors.affiliation: Beecham Pharmaceuticals Research Division, Tadworth, Surrey, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Hood
authors.forename: R M
authors.initials: RM
authors.lastname: Banks
authors.forename: M D
authors.initials: MD
authors.lastname: Brewer
authors.forename: J P
authors.initials: JP
authors.lastname: Fish
authors.forename: B R
authors.initials: BR
authors.lastname: Manger
authors.forename: M E
authors.initials: ME
authors.lastname: Poulton
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005849:Gerbillinae; D006189:Haemonchus / Q000187:drug effects; D018942:Macrolides; D015394:Molecular Structure; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*; D014253:Trichostrongylosis / Q000188:drug therapy
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin