The coiled-coil molecules of intermediate filaments consist of two parallel chains in exact axial register.
Amino acid sequence studies of helical particles derived from proteolytic digests of mouse epidermal keratin intermediate filaments (IF) have shown that their coiled-coil molecules are heterodimers of Type I and Type II keratins, with a parallel arrangement of the two chains. From a reappraisal of published chemical cross-linking data, it is concluded that the coiled-coil molecules in all IF consist of pairs of parallel chains in precise axial register.
Parry
D A
DA
Steven
A C
AC
Steinert
P M
PM
D000595:Amino Acid Sequence; D000818:Animals; D003599:Cytoskeleton / Q000648:ultrastructure*; D004817:Epidermis / Q000648:ultrastructure*; D007633:Keratins; D046911:Macromolecular Substances; D051379:Mice; D011487:Protein Conformation
D046911:Macromolecular Substances; D007633:Keratins