[Effect of Polfos on the bleeding time. III. Changes in various parameters of the circulatory system].
The influence of Polfos on the blood pressure in rats was measured by direct and indirect methods. The influence of this pesticide on the heart rate was also examined. Two hours after Polfos administration an increase in blood pressure and a decrease in heart rate were observed. In the late phase of Polfos-intoxication no changes in the cardiovascular system were found. The results show that prolonged bleeding time in the initial phase of the intoxication might depend on its influence on the cardiovascular system in rats.
Konopelko
M
M
Z Akademii Medycznej w Białymstoku, Zakład Farmakodynamiki Kierownik Zakładu.
Malinowska
B
B
Chabielska
E
E
Buczko
W
W
D000818:Animals; D001760:Bleeding Time; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000139:chemically induced*; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000506:poisoning*; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007306:Insecticides; C006037:methylbromfenvinphos; D002709:Chlorfenvinphos
Wplyw Polfosu na czas krwawienia. III. Zachowanie see niektórych parametrów układu krazenia.