Sustained cytopenia after leukapheresis for collection of peripheral blood stem cells in small children.
Marked and persistent cytopenia was observed in two 3-year-old children with cancer, after lymphopheresis to collect peripheral blood stem cells (PBSC) for autotransplantation after high-dose chemotherapy. This finding suggests that PBSC are a major component of the hematopoietic cells in small children and, hence, that special care is necessary in the construction of a protocol for collection of stem cells from young children.
Takaue
Y
Y
Department of Pediatrics, University Hospital of Tokushima, Japan.
Watanabe
T
T
Kawano
Y
Y
Koyama
T
T
Abe
T
T
Suzue
T
T
Shimokawa
T
T
Ninomiya
T
T
Kuroda
Y
Y
D002675:Child, Preschool; D002985:Clinical Protocols; D005260:Female; D006410:Hematopoiesis / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007937:Leukapheresis / Q000009:adverse effects*; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000628:therapy*; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000628:therapy*; D012008:Recurrence