Short term toxicity study in rats dosed with isoeugenol benzyl ether.
Isoeugenol benzyl ether was given to rats by gavage for 28 days at 0, 60, 120, and 240 mg/kg body weight/day. For both sexes at the highest dose and females at the intermediate dose statistically significantly decreased values were found for body weight, blood glucose (also for males at intermediate dose), blood urea and relative liver weights. No dose-related histopathological changes were seen in any organs. The no effect level was 60 mg/kg body weight/day.
Boe
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National Food Agency, Institute of Toxicology, Søborg, Denmark.
Würtzen
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Olsen
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005054:Eugenol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000097:blood
D001786:Blood Glucose; C062158:isoeugenol benzyl ether; D005054:Eugenol; D014508:Urea