title: Cell metabolism in patients undergoing major valvular heart surgery: relationship with intra and postoperative hemodynamics, oxygen transport, and oxygen utilization patterns.
abstract: The relationships between cell metabolism and both hemodynamics and oxygen transport/utilization (VO2/DO2) pattern were evaluated intra and postoperatively in eight patients undergoing major valvular heart surgery with the aid of moderately hypothermic cardiopulmonary bypass (CPB). Quadriceps femoris specimens were obtained by the needle biopsy technique for muscle ATP, ADP, AMP, phosphocreatine (PCr), creatine and lactate determination at anesthesia induction, after CPB, as well as in the ICU 18 h after surgery. Moreover, hemodynamic variables, oxygen transport and utilization indices, and plasma lactate were measured at the same intervals and throughout the CPB period. After CPB, muscle ATP and PCr contents were reduced (p less than .05) as compared to those of both pre-CPB patients and healthy control subjects; muscle and plasma lactate levels were increased (p less than .05). Mean VO2 and DO2 values measured during CPB significantly decreased (p less than .05), but VO2 reduction was proportionally greater than that of DO2 (-62% vs. -41%). No correlation was found between VO2 and DO2 at that time, but a significant relationship (p less than .05) was found at the end of CPB. A further decrease in muscle ATP and PCr levels was measured in the ICU, as muscle and plasma lactate levels were still elevated. At that time, VO2 and DO2 were not significantly different from pre-CPB values, but were significantly (p less than .05) correlated with each other.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Fiaccadori
authors.forename: A
authors.initials: A
authors.lastname: Vezzani
authors.forename: E
authors.initials: E
authors.lastname: Coffrini
authors.forename: A
authors.initials: A
authors.lastname: Guariglia
authors.forename: N
authors.initials: N
authors.lastname: Ronda
authors.forename: G
authors.initials: G
authors.lastname: Tortorella
authors.forename: P
authors.initials: P
authors.lastname: Vitali
authors.forename: S
authors.initials: S
authors.lastname: Pincolini
authors.forename: C
authors.initials: C
authors.lastname: Beghi
authors.forename: F
authors.initials: F
authors.lastname: Fesani
mesh_terms: D000227:Adenine Nucleotides / Q000032:analysis; D000368:Aged; D002315:Cardiopulmonary Bypass; D003401:Creatine / Q000032:analysis; D005260:Female; D006349:Heart Valve Diseases / Q000378:metabolism* / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D007432:Intraoperative Period; D007773:Lactates / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis; D010100:Oxygen / Q000502:physiology*; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000032:analysis; D011184:Postoperative Period
chemical_list: D000227:Adenine Nucleotides; D007773:Lactates; D010725:Phosphocreatine; D003401:Creatine; D010100:Oxygen