title: Verapamil-induced gingival overgrowth: a clinical, histologic, and biochemic approach.
abstract: Verapamil-induced overgrowth was most prominent in the anterior regions and interproximal areas associated with plaque retention. Despite periodontal therapy, overgrowths recurred 1 month after gingivectomy. Discontinuation of the drug resulted in regression of the overgrowths. Histologic findings showed inflamed connective tissue covered by an acanthotic, thickened oral epithelium with long rete pegs containing dyskeratotic pearls. The proliferation rate and protein and collagen production of fibroblasts from the overgrowth sites were markedly lower than in the control cells cultured from healthy gingiva. Incubation of fibroblasts in the presence of verapamil reduced protein and collagen synthesis.
authors.affiliation: Institute of Dentistry, University of Oulu, Finland.
authors.forename: H E
authors.initials: HE
authors.lastname: Pernu
authors.forename: K
authors.initials: K
authors.lastname: Oikarinen
authors.forename: J
authors.initials: J
authors.lastname: Hietanen
authors.forename: M
authors.initials: M
authors.lastname: Knuuttila
mesh_terms: D000328:Adult; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D005888:Gingival Pocket / Q000473:pathology; D006801:Humans; D012008:Recurrence; D014700:Verapamil / Q000009:adverse effects*
chemical_list: D014700:Verapamil