2,2'-Dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent.
The activity of 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone (II, C.D.R.I. Comp. 82/437) has been evaluated for its micro- and macro-filaricidal efficacy against Litomosoides carinii in rodents. A dose of 3 mg/kg (i.p.) and 50 mg/kg (oral) x 5 days of Comp. 82/437 was found to eliminate almost 100% of adult worms and microfilariae of L. carinii in cotton rat. It also killed 100% and 97% of adult worms and microfilariae of Dipetalonema viteae and Brugia malayi in Mastomys natalensis respectively, at 150 and 200 mg/kg x 5 days orally. The compound also exhibited marked chemoprophylactic and in vitro activity against L. carinii.
Fatma
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N
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Sharma
S
S
Chatterjee
R K
RK
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003411:Arvicolinae; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D004049:Diethylcarbamazine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D005370:Filarioidea / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D051379:Mice
D000871:Anthelmintics; D001562:Benzimidazoles; D005369:Filaricides; C062733:2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone; D008463:Mebendazole; D004049:Diethylcarbamazine