[The effect of anthracyclines on heart mitochondria respiration during the action of creatine phosphokinase].
It was shown that during glutamate+malate oxidation in the presence of creatine, antitumour anthracycline antibiotics strongly inhibit the rate of oxygen uptake by rat heart mitochondria; ADP excess activated the respiration up to the initial level, i.e., that observed after the first addition of ADP. Carboxyatractyloside addition to a system containing creatine (or hexokinase+glucose) results in the stimulation of rubomycin-induced mitochondrial respiration. Substitution of carboxyatractyloside by oligomycin gives very similar results. It is supposed that anthracycline antibiotics exert a manyfold effect on heart mitochondrial membranes which results in impaired compartmentation of enzymatic systems providing for oxidative phosphorylation.
Gorskaia
I A
IA
Kaverinskaia
T V
TV
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001278:Atractyloside / Q000031:analogs & derivatives / Q000494:pharmacology; D003402:Creatine Kinase / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology; D004347:Drug Interactions; D008929:Mitochondria, Heart / Q000187:drug effects*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D000903:Antibiotics, Antineoplastic; D001278:Atractyloside; D000244:Adenosine Diphosphate; D003402:Creatine Kinase; C003853:carboxyatractyloside; D003630:Daunorubicin
Vliianie antratsiklinov na dykhanie mitokhondriĭ serdtsa v usloviiakh raboty kreatinfosfokinazy.