Attenuating effects of diazepam on the electroretinogram of normal humans.
Response/log I curves were obtained under conditions of dark-and light-adaptation in seven normal male volunteers. For each subject, a baseline electroretinogram (ERG) was recorded. In the same afternoon, a second ERG was obtained after 0.05 mg/kg diazepam, and a third ERG was recorded following 0.10 mg/kg diazepam. Under conditions of dark-adaptation, the following dose-dependent changes were identified: 1) Diazepam attenuated the rod b-wave peak amplitude and increased its implicit time; 2) The dark-adapted longer wavelength cone a-wave and 'blue cone' b-wave showed an increased implicit time; 3) All oscillatory potentials showed an increased implicit time. Under conditions of light-adaptation, dose-dependent decreases in peak amplitude and delays in implicit time were observed for the a- and b-waves. The effects of diazepam on the human ERG were more profound under conditions of light- than dark-adaptation.
Jaffe
M J
MJ
National Eye Institute, Bethesda, MD.
Hommer
D W
DW
Caruso
R C
RC
Straw
G M
GM
de Monasterio
F M
FM
D000328:Adult; D003623:Dark Adaptation; D003975:Diazepam / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000187:drug effects*; D006801:Humans; D008297:Male; D009991:Oscillometry; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism; D011897:Random Allocation; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D003975:Diazepam; D004298:Dopamine