title: Clinical chronopharmacology of oral nitrates.
abstract: The clinical-chronopharmacological investigations with oral nitrates (ISDN, IS-5-MN) demonstrate that the drugs' pharmacokinetics and/or hemodynamic effects are circadian phase-dependent. For both an immediate-release and a sustained-release preparation of IS-5-MN peak drug concentrations coincided with peak drug effects after morning but not after evening drug application. Results indicate a circadian phase-dependency in the dose-response relationship of oral nitrates.
authors.affiliation: Zentrum der Pharmakologie, J. W. Goethe-Universität Frankfurt.
authors.forename: B
authors.initials: B
authors.lastname: Lemmer
authors.forename: B
authors.initials: B
authors.lastname: Scheidel
authors.forename: G
authors.initials: G
authors.lastname: Stenzhorn
authors.forename: H
authors.initials: H
authors.lastname: Blume
authors.forename: G
authors.initials: G
authors.lastname: Lenhard
authors.forename: D
authors.initials: D
authors.lastname: Grether
authors.forename: J
authors.initials: J
authors.lastname: Renczes
authors.forename: H J
authors.initials: HJ
authors.lastname: Becker
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D003692:Delayed-Action Preparations; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate