[Evaluation of the antiatherosclerotic properties of natural compounds of plant origin on cell cultures of the human aortic intima].
Administration of alizole, berberine, pheonol and pheoniphlorine in doses of 30-100 micrograms/ml in the culture of the atherosclerotic human aortic intimal cells decreased the content of intracellular cholesterol by 35-41% and reduced the proliferative activity of the cells. In healthy donors administration of single doses of berberine and pheoniphlorine (0.9 g) increased the antiatherogenic potential of the serum which was estimated on the primary culture of the intimal cells.
Ren
L H
LH
Vasil'ev
A V
AV
Orkehov
A N
AN
Tertov
V V
VV
Tutel'ian
V A
VA
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D010936:Plant Extracts; D002784:Cholesterol
Otsenka antiateroskleroticheskikh svoĭstv nekotorykh prirodnykh soedineniĭ rastitel'nogo proiskhozhdeniia na kul'ture kletok intimy aorty cheloveka.