title: Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse.
abstract: We describe the immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and myelin basic protein (MBP) in CNS of the jimpy mutant mouse which is characterized by dys- and demyelination. In controls, the CNPase and MBP were localized exclusively in white matter in the CNS. The jimpy mutant mice were severely affected: A very weak reaction was observed in the white matter. Very few CNPase- and MBP-positive myelin sheaths were observed, and some degradation products were also observed after reaction with antisera against both CNPase and MBP. The immunohistochemical reaction in the jimpy mice showed a similar localization in both CNPase and MBP.
authors.forename: K
authors.initials: K
authors.lastname: Mikoshiba
authors.forename: S
authors.initials: S
authors.lastname: Kohsaka
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000032:analysis*; D000818:Animals; D002490:Central Nervous System / Q000032:analysis*; D006651:Histocytochemistry; D051379:Mice; D008816:Mice, Jimpy; D004676:Myelin Basic Protein / Q000032:analysis*; D014018:Tissue Distribution
chemical_list: D004676:Myelin Basic Protein; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases