Psychosis of epilepsy--an approach to a biological basis for postictal and interictal psychoses.
Postictal and interictal changes in behavior and the corresponded neurochemical data in the kindling model of epilepsy are reviewed briefly to explore a biological base for epileptic psychosis. Kindling can be a potent animal model to study this problem. A possible participation of both TRH and opioid system in prolonged postictal behavior disorder and of TRH, mesolimbic system and/or PI response to excitatory amino acid in interictal behavior disorder are discussed. A further experimental study is required to disclose the basic mechanism of epileptic psychosis.
Sato
M
M
Department of Psychiatry, Tohoku University Medical School, Sendai, Japan.
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D019965:Neurocognitive Disorders / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology*
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter