Synthesis of novel 2-chloro-1,4-dihydropyridines by chlorination of 2-hydroxy-1,4-dihydropyridines with phosphorus oxychloride.
Novel 2-chloro-1,4-dihydropyridine derivatives were synthesized by chlorination of 2-hydroxy-1,4-dihydropyridines with POCl3. The dihydropyridines chlorinated at position 2 exhibited more potent vasodilative and hypotensive activities than the dihydropyridines (nicardipine and nitrendipine) with a methyl group at position 2.
Cho
H
H
Ueda
M
M
Mizuno
A
A
Ishihara
T
T
Aisaka
K
K
Noguchi
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D010758:Phosphorus; D017553:Phosphorus Compounds; D051381:Rats
D000959:Antihypertensive Agents; D004095:Dihydropyridines; D007202:Indicators and Reagents; D017553:Phosphorus Compounds; D010758:Phosphorus; C013196:phosphoryl chloride