Effect of aluminium on superoxide dismutase.
1. The effect of Al3+ on superoxide dismutase in vitro was studied, since in uraemia there is excessive superoxide production and frequently an elevated serum Al3+ level. Thus, the protective role of superoxide dismutase is particularly important. 2. Al3+ in concentrations similar to those found in the serum of uraemic patients inhibits superoxide dismutase activity. The degree of inhibition is directly proportional to the Al3+ level. 3. The combination of excessive oxygen free radical production with an increased Al3+ level may contribute to a variety of complications, including aluminium dementia or initiation and promotion of carcinogenic processes, which are known to be more common in uraemic patients.
Shainkin-Kestenbaum
R
R
Nephrology Section, Brooklyn VA Medical Center, New York 11209.
Adler
A J
AJ
Berlyne
G M
GM
Caruso
C
C
D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*
D000535:Aluminum; D013482:Superoxide Dismutase