[The role of cholinergic receptors in the reactions of the hemostasis system to vasopressin].
Participation of central and peripheral++ cholinoreceptors in responses of blood coagulation system to intravenous vasopressin injection has been studied in experiments on white rats. Vasopressin was injected in combination with atropine and metacine Intensification of the procoagulant activity, that was observed 15 min after vasopressin injection (4 micrograms/kg), was practically retained during cholinergic blockade. The intensification of fibrinolytic activities as a result of an increase in the level of plasminogen activators in blood, is to a great extent blocked by atropine rather than by metacine. Consequently, to intensify the procoagulant activity without changes in fibrinolysis (for example hemophilia) it is necessary to use the vasopressin injection in combination with atropine.
Kalishevskaia
T M
TM
Golubeva
M G
MG
Solo'veva
M E
ME
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology; D007275:Injections, Intravenous; D007601:Jugular Veins; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*
D011950:Receptors, Cholinergic; D014667:Vasopressins; D000109:Acetylcholine
Uchastie kholinoretseptorov v reaktsiiakh sistemy gemostaza na vazopressin.