[Effects of scopolamine on delayed matching and non-matching to sample responses in T-maze in rats].
The present study was designed to investigate the effects of scopolamine (SCP; 0.25 and 0.5 mg/kg, ip) on delayed matching and non-matching to sample (DMTS and DNMTS) responses in T-maze in rats. The groups consisted of the animals (N = 14) trained on the DMTS task with a short (3 min) intertrial interval (ITI), those (N = 12) on the DNMTS task with the short ITI, and those (N = 25) on the DNMTS task with a long (20 min) ITI. The results showed that (1) the DMTS task required a significantly larger number of trials to acquire than the DNMTS task, (2) the decay of performance with delay between information and choice runs was more pronounced in DMTS than in DNMTS, (3) the number of correct choices was smaller in the DNMTS responses with the short ITI than in those with the long ITI, (4) the disruptive effects of SCP were more marked in the DMTS than DNMTS responses, and (5) the effects of SCP in the DNMTS responses with the short ITI were not different from those in the responses with the long ITI. These results were discussed in terms of innate response (win-shift and win-stay) strategy, and working and reference memory components. It was concluded that SCP exerted the detrimental effects on both working and reference memory components.
Furukawa
S
S
Institute of Psychology, University of Tsukuba, Ibaraki, Japan.
Iwasaki
T
T
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology*
D012601:Scopolamine