[The effect of 5-fluorouracil, metronidazole, caffeine and irradiation on the synthesis of DNA in the Pliss lymphosarcoma].
Injection of 5-fluorouracil or caffeine or a combination of each of them with metronidazole removes partially or wholly the postirradiation arrest of DNA synthesis in Pliss lymphosarcoma and increases the label index and (or) the rate of its incorporation in nuclei of DNA-synthesizing cells compared to irradiated controls. The administration of the three agents arrests almost completely the DNA synthesis during the very first hours following irradiation, then prematurely removes partially the synthesis block in most DNA-synthesizing cells.
Ermekova
S A
SA
Esel'baeva
G O
GO
Urunbaev
S U
SU
D000818:Animals; D002110:Caffeine / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005472:Fluorouracil / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D008795:Metronidazole / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats
D004273:DNA, Neoplasm; D008795:Metronidazole; D002110:Caffeine; D005472:Fluorouracil
Vliianie 5-ftorouratsila, metronidazola, kofeina i oblucheniia na sintez DNK v limfosarkome Plissa.