Antibody-mediated suppression of the immune response is determinant specific.
It was studied whether antibody-mediated suppression of the immune response was determinant specific. Fluorescein isothiocyanate (FITC)-conjugated sheep red cells were used as the immunogen and antibodies were raised both against the carrier sheep red cells and the hapten FITC. When these antibodies were injected 1-3 h after the immunogen they only suppressed the immune response to the corresponding determinant. Anti-carrier antibodies usually enhanced the response to the hapten. Therefore, antibody-mediated suppression of the immune response is determinant specific and cannot be mediated in vivo to a detectable extent by the Fc part of the antibodies.
Möller
G
G
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins / Q000276:immunology; D006241:Haptens / Q000276:immunology; D007108:Immune Tolerance; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D012756:Sheep; D013861:Thiocyanates / Q000276:immunology
D000906:Antibodies; D000939:Epitopes; D005452:Fluoresceins; D006241:Haptens; D007141:Immunoglobulin Fc Fragments; D013861:Thiocyanates; D016650:Fluorescein-5-isothiocyanate