title: Changes in the ratio of two separate toxin binding sites on the sodium channel protein during rat brain development.
abstract: The development of two separate toxin binding sites from sodium channels of rat brain was studied. Whereas [3H]saxitoxin binding developed gradually, reaching adult levels by 4.5 weeks after birth, the binding of [125I]scorpion toxin increased rapidly for the first 10 days after birth, then declined. The stoichiometric ratio of [3H]saxitoxin binding site to [125I]scorpion toxin binding sites changed during development from 0.5 in 8 day old rats to 1.9 in adult rats, implying separate biological regulation for each of these sites.
authors.forename: J
authors.initials: J
authors.lastname: Baumgold
mesh_terms: D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012530:Saxitoxin / Q000378:metabolism*; D012604:Scorpion Venoms / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D012604:Scorpion Venoms; D012530:Saxitoxin