[Transmembrane effects in the sodium pump system. II. The ratio of the sodium efflux to the sodium concentration in frog muscle in media with various sodium substitutes].
The dependence of sodium efflux on the internal sodium concentration on sodium-free magnesium, Tris, coline and lithium media was investigated on frog striated muscle. In all the sodium-substituted media, the efflux concentration curve was found to be dependent on the external rubidium concentration, being S-shaped at the saturating external rubidium (potassium) concentration and becoming close to linear at the low external rubidium concentration (0.5-1.0 microM). The maximal sodium efflux at saturating levels of internal sodium concentrations remains unchanged with various sodium substitutes in the medium, whereas the affinity constant of internal sodium sites is dependent on the external cations.
Vinogradova
T A
TA
Marakhova
I I
II
D000818:Animals; D002794:Choline / Q000494:pharmacology; D003470:Culture Media / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011896:Rana temporaria; D012413:Rubidium / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D014325:Tromethamine / Q000494:pharmacology
D003470:Culture Media; D007473:Ion Channels; D014325:Tromethamine; D008094:Lithium; D012964:Sodium; D008274:Magnesium; D012413:Rubidium; D002794:Choline
Transmembrannye éffekty v sisteme natrievogo nasosa. II. Zavisimost' vykhodnogo potoka natriia ot konstsentratsii natriia v myshtse liagushki v sredakh s raznymi zameniteliami natriia.