[Study of Ag-NOR, SCE and micronucleus in peripheral blood lymphocyte of chromate producers].
Ag-NOR, SCE and micronucleus test of peripheral blood lymphocyte obtained from 31 chromate producers had been studied. We found that (1) in the workers who had been exposed over eight years, the frequency of Ag-NOR, Ag-AA and SCE were 6.905 +/- 1.100, 0.380 +/- 0.652 and 8.190 +/- 3.727, but in the control group, 6.512 +/- 1.595, 0.215 +/- 0.529 and 7.171 +/- 2.683, respectively. So there was considerably significant difference between the exposed and the unexposed (P less than 0.01); (2) the frequency of micronuclei was 3.71 +/- 1.419% in the exposed group; however, in the control group it was 0.333 +/- 0.479%. So there was also remarkably significant difference between them (P less than 0.001). The observations lead the authors to conclude that the genetic material of the workers who have been working over eight years may be damaged because of being exposed to chromate.
Hu
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Li
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Zhang
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Zheng
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Wang
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D000328:Adult; D002840:Chromates / Q000506:poisoning*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000187:drug effects; D009784:Occupational Diseases / Q000235:genetics*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002840:Chromates