title: [Opioid peptides, regulators of acetylcholinesterase activity].
abstract: Studies have been made on the opioid peptides--enkephalins their fragments, and alpha- and gamma-endorphins with concentrations of 10(-8)-10(-4) M, on acetylcholinesterase of human blood erythrocytes. It was found out that these peptides, which were fragments of one propeptide beta-LPH were reversible effectors of acetylcholinesterase. Enkephalins and a number of their fragments were noncompetitive inhibitors. It was shown that natural pentapeptide has the highest inhibitor activity; decreasing of inhibitor activity or the absence of it was a result of pentapeptide molecules degradation. Short endorphins were noncompetitive activators of acetylcholinesterase.
authors.forename: S A
authors.initials: SA
authors.lastname: Muranevich
authors.forename: M V
authors.initials: MV
authors.lastname: Polosatov
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004723:Endorphins / Q000502:physiology*; D004745:Enkephalins / Q000502:physiology; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans
chemical_list: D002800:Cholinesterase Inhibitors; D004723:Endorphins; D004745:Enkephalins; D000110:Acetylcholinesterase
vernacular_title: Opioidnye peptidy--reguliatory aktivnosti atsetilkholinésterazy.