Evaluation of antileishmanial activity of trans-aconitic acid.
TAA, an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote (table; see text) form in vitro was also inhibited by 2 mM TAA. TAA also reduced multiplication of the parasite in macrophage culture. In the hamster model of leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day.
Misra
S
S
Department of Immunochemistry, Indian Institute of Chemical Biology, Calcutta.
Sanyal
T
T
Sarkar
D
D
Bhattacharya
P K
PK
Ghosh
D K
DK
D000156:Aconitic Acid / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology; D008264:Macrophages / Q000469:parasitology; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D014233:Tricarboxylic Acids / Q000494:pharmacology*
D014233:Tricarboxylic Acids; D000156:Aconitic Acid