title: Antibiotic persistence and tolerance in the lactating sheep following a course of intramammary therapy.
abstract: The commercial use of sheep for the production of milk and milk products is attractive to farmers actively diversifying their dairy interests due to the impact of the quota system. As intensification of milking increases, flock sizes will enlarge and the incidence of ovine mastitis will inevitably increase. The pharmaceutical industry and the veterinary practitioner will be required to provide advice and data upon the performance of currently available bovine intramammary preparations for the sheep. This study produces evidence to confirm that one available bovine intramammary preparation, when infused into milking sheep, produced a withholding time approximately three times as long as that defined for the cow. Following a course of three infusions over a period of 24 hours after consecutive milkings, milk was not acceptable for human consumption or for the production of cheese and yoghurts until 136 hours following the final infusion. This situation is likely to be representative of that which will occur with other intramammary products used in the ovine species following infusion with bovine intramammary preparations.
authors.forename: J F
authors.initials: JF
authors.lastname: Buswell
authors.forename: D M
authors.initials: DM
authors.lastname: Barber
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D000818:Animals; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D004361:Drug Tolerance; D005260:Female; D007774:Lactation / Q000187:drug effects / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000187:drug effects; D008892:Milk / Q000032:analysis / Q000166:cytology; D011247:Pregnancy; D012756:Sheep / Q000378:metabolism*
chemical_list: D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin