HLA-DQ mismatches between donor and recipient in the presence of HLA-DR compatibility do not influence the function or outcome of renal transplants.
Although matching of kidney donors and recipients for antigens of the HLA-DR series is considered to have a significant influence on graft outcome, the independent effects of incompatibilities for the closely linked HLA-DQ series of antigens are unknown largely because serological compatibility for HLA-DR usually ensures a corresponding compatibility for HLA-DQ. In a retrospective study using restriction fragment analysis we have identified clear HLA-DQ mismatches in 25 out of 62 recipients of HLA-DR-compatible kidney grafts. Though these incompatibilities correspond to differences at the cell surface and hence potential alloantigenic stimuli, none of the eight clinical parameters examined indicate that HLA-DQ mismatches in the presence of compatibility for HLA-DR have any significant effect on either graft function or outcome.
Bushell
A
A
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom.
Higgins
R M
RM
Wood
K J
KJ
Morris
P J
PJ
D000293:Adolescent; D000328:Adult; D001345:Autoradiography; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006085:Graft Survival / Q000187:drug effects / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012189:Retrospective Studies
D003524:Cyclosporins; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D001379:Azathioprine