Further evidence supporting the role of the serotonin system in suicidal behavior: a preliminary study of suicide attempters.
The 3H-imipramine binding parameters (Bmax and Kd) were studied in platelets from female suicide attempters and from healthy volunteers. The Bmax was significantly lower among suicide attempters, with no modification of the Kd. These results provide support of the hypothesis that decreased serotonin function may play a role in suicidal behavior.
Marazziti
D
D
Department of Psychiatry, University of Pisa, Italy.
De Leo
D
D
Conti
L
L
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000502:physiology*; D012307:Risk Factors; D012701:Serotonin / Q000097:blood*; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*
D011985:Receptors, Serotonin; D012701:Serotonin; D007099:Imipramine