Gas chromatographic-mass spectrometric investigation of four commercial pristane (2.6.10.14-tetramethylpentadecane) preparations used for plasmacytoma induction in BALB/c mice.
The most widely studied model of plasmacytomagenesis is the induction of plasmacytomas by intraperitoneal injections of pure alkanes such as pristane (2.6.10.14-tetramethylpentadecane). The presence of small amounts of genotoxic contaminants, that could contribute to the complex oncogenic process, in commercial pristane preparations has not been completely ruled out. Therefore, we conducted a chemical analysis of different pristane preparations applying a combined GC/MS technique, but were not capable of identifying any obvious or putative genotoxic/cancerogenic contaminants.
Janz
S
S
Institute of Clinical Immunology, Faculty of Medicine, Karl Marx University Leipzig.
Birkenfeld
T
T
Herzschuh
R
R
Storch
H
H
D000818:Animals; D002273:Carcinogens / Q000032:analysis*; D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D010954:Plasmacytoma / Q000139:chemically induced*; D013729:Terpenes / Q000032:analysis*
D002273:Carcinogens; D013729:Terpenes; C009042:pristane