Lack of in vivo activation of the interferon system in HBsAg-positive chronic active hepatitis.
The in vivo activation state of the interferon system was biochemically evaluated in patients with HBsAg-positive liver disease by assaying the interferon-induced enzyme, 2'5'-oligoadenylate synthetase, in peripheral blood mononuclear cells. All patients with chronic active hepatitis had normal levels of enzyme activity. Increased values were found in 77% of patients with acute hepatitis, 50% of those with chronic persistent hepatitis and 54% chronic healthy carriers. These results provide evidence for lack of activation of the interferon system in HBsAg-positive chronic active hepatitis and support the hypothesis that an in vivo defective interferon response may aid in development of chronic active hepatitis.
Poitrine
A
A
Chousterman
S
S
Chousterman
M
M
Naveau
S
S
Thang
M N
MN
Chaput
J C
JC
D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood; D000328:Adult; D000368:Aged; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000097:blood / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase