title: Synthesis of novel 2-chloro-1,4-dihydropyridines by chlorination of 2-hydroxy-1,4-dihydropyridines with phosphorus oxychloride.
abstract: Novel 2-chloro-1,4-dihydropyridine derivatives were synthesized by chlorination of 2-hydroxy-1,4-dihydropyridines with POCl3. The dihydropyridines chlorinated at position 2 exhibited more potent vasodilative and hypotensive activities than the dihydropyridines (nicardipine and nitrendipine) with a methyl group at position 2.
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: A
authors.initials: A
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: K
authors.initials: K
authors.lastname: Aisaka
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D010758:Phosphorus; D017553:Phosphorus Compounds; D051381:Rats
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; D007202:Indicators and Reagents; D017553:Phosphorus Compounds; D010758:Phosphorus; C013196:phosphoryl chloride