Synthesis and pharmacological properties of new derivatives of 1-diphenylacetamide-2-butanol.
Newly synthesized derivatives of 1-diphenylacetamide-2-butanol were investigated pharmacologically for their central properties in mice and rats. The most active were 2 compounds: racemic (RS) and enantiomer S (+) form of N-diphenylacetamide-2-butanol which produced hypothermia in normothermic mice, showed anxiolytic action in the four-plate test and reversed reserpine-induced hypothermia.
Kolasa
K
K
Department of Pharmacology, Medical Academy, Lublin.
Kleinrok
Z
Z
Pietrasiewicz
T
T
Czechowska
G
G
Zejc
A
A
Gajewczyk
L
L
D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D000081:Acetamides; D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D011619:Psychotropic Drugs; C065122:1-(N-diphenylacetamido)-2-butanol; C065123:1-(N-di-(4'-chlorophenyl)acetamido)-2-butanol