title: [Biosynthesis of nucleic acids and proteins in different time periods of development in experimental myocarditis].
abstract: Biosynthesis of DNA, RNA and protein was studied in rat myocardium within 1, 3, 5, 7, 14, 21 and 28 days after administration of adrenaline toxic doses (300 mg/100 g of body mass). Synthesis of DNA was activated within 1-7 days, of total proteins--within 1-14 days, of RNA--within 1-"1 days, of action and myosin in myocardium--within 3-21 days. All the patterns studied were normalized within the subsequent periods (21-28 days) although they exceeded the control values. These data and morphological assays suggest that restoration processes were activated due to regeneration of the impaired cardiomyocytes or to proliferation of fibroblasts.
authors.forename: I F
authors.initials: IF
authors.lastname: Paskevich
authors.forename: V M
authors.initials: VM
authors.lastname: Denisov
authors.forename: S M
authors.initials: SM
authors.lastname: Rukavishnikova
authors.forename: V I
authors.initials: VI
authors.lastname: Pakhomov
authors.forename: V G
authors.initials: VG
authors.lastname: Kalimanov
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004837:Epinephrine / Q000633:toxicity; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
chemical_list: D012313:RNA; D004247:DNA; D004837:Epinephrine
vernacular_title: Issledovanie biosinteza nukleinovykh kislot i belkov v razlichnye sroki razvitiia éksperimental'nogo miokardita.