The roles of two peritoneal T-lymphocyte populations in the in vivo rejection of methylcolanthrene-induced sarcoma.
Two phenotypically distinct T-lymphocyte populations infiltrating the peritoneal site of active tumor rejection were found to have specific reactivity against methylcolanthrene (MCA)-induced sarcoma(s) in two separate biological assays. One, expressing a Lyt 1+2- phenotype, mediates specific delayed type hypersensitivity (DTH) reaction to the immunizing MCA tumor transplantation antigen, and the other, expressing a Lyt 1+2+ phenotype, transfers in vivo protection against the MCA tumor in Winn assay. This latter antitumor immunity was specific for individually distinct transplantation antigens of each MCA sarcoma line. In contrast, standard transplantation tests by direct (whole animal) challenge demonstrated considerable tumor cross-reactivity. These findings and the relative contributions of the two T-cell populations are discussed in terms of effector mechanism.
Kadhim
S A
SA
Rees
R C
RC
Barrington-Leigh
J
J
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics; D003429:Cross Reactions; D000939:Epitopes; D005260:Female; D006084:Graft Rejection; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007116:Immunization, Passive; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000166:cytology; D010641:Phenotype; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification* / Q000502:physiology
D000951:Antigens, Neoplasm; D000939:Epitopes; D008748:Methylcholanthrene