[A pharmacological analysis of the anxiolytic action of derivations of benzodiazepine, GABA and beta-carboline in various tests of tension reaction].
In the test of avoidance of an "illuminated platform" and "precarious situation" intraperitoneal administration of derivatives of benzodiazepine, GABA and beta-carboline was shown to attenuate anxiety states in rats. The similar effect was also observed at local administration of serotonin and beta-carboline into the median raphe nuclei. At the same time microinjections of GABA, chlordiazepoxide, phenibut and baclofen into this formation of the brain exerted the anxiolytic effect only in the test of an "illuminated platform". Different spectra of the anxiolytic effect of the tested psychotropic agents is suggested to be due to diverse degrees of the involvement of serotoninergic and GABA-ergic systems of the median raphe nucleus in the anxiety states formed by various aversive actions.
Talalaenko
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy*; D001362:Avoidance Learning / Q000187:drug effects; D001569:Benzodiazepines; D002243:Carbolines / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008297:Male; D008845:Microinjections; D011903:Raphe Nuclei / Q000187:drug effects; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D002243:Carbolines; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid
Farmakologicheskiĭ analiz anksioliticheskogo deĭstviia proizvodnykh benzodiazepina, GAMK i beta-karbolina v razlichnykh testakh reaktsii napriazheniia.