[The synthesis of P-substituted DL-2-phenylglycine octylesters].
9 Titel compounds (p-RC6H4)CH(NH2.HCl)COO (CH2)7CH3 [R = F, Cl, HO, CH3O, CH3(CH2)3O, C6H5CH2O, CH3, (CH3)2CH and (CH3)2N.HCl] were obtained by esterification of p-substituted DL-2-phenylglycines with octanol either in the presence of dry hydrogen chloride (procedure A) or with thionyl chloride (procedure B). The advantages of the procedure B are the mild conditions, the more pure products, the possibility of esterification of diamino acids, and the stability of alkoxy groups as substituents. The synthesized octylesters are potential antiinflammatory and analgesic substances with spasmolytic activity.
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Institut für Pharmakologie und Toxikologie Bereich Medizin der Wilhelm-Pieck-Universität Rostock.
Kobow
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M
Schulz
E
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010276:Parasympatholytics / Q000138:chemical synthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010276:Parasympatholytics; D005998:Glycine
Zur Synthese p-substituierter DL-2-Phenylglycinoctylester.