The influence of HLA matching on renal allograft survival at a single pediatric center.
Between January 1, 1969, and February 2, 1988, 331 pediatric renal transplants were performed at a single pediatric center. Of these 225 were first cadaveric allografts. Graft allocation was independent of the outcome of human lymphocyte antigen (HLA) matching. The results of class I antigen matching were analyzed in 224 transplants, and actuarial graft survivals were calculated. Class II antigen matching was analyzed in 80 patients from January 1, 1982, and submitted to the same analysis. HLA matching could not be demonstrated to be beneficial. It is proposed that any matching benefit is small and obscured in our series by the dominance of other factors.
McMullin
N D
ND
Department of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Aliabadi
H
H
McLorie
G A
GA
Churchill
B M
BM
D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000276:immunology / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology*; D014184:Transplantation, Homologous
D006680:HLA Antigens