Effectiveness of insulin suppositories in diabetic patients.
Experimental insulin suppositories regulated postprandial hyperglycaemia in diabetic patients. The insulin suppositories seemed also to avoid hyperinsulinaemia. The formulation with more rapid dissolution of insulin, which contained a solid dispersed form of insulin, effectively reduced the insulin dose required.
Nishihata
T
T
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Kamada
A
A
Sakai
K
K
Yagi
T
T
Kawamori
R
R
Shichiri
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D013488:Suppositories
D001786:Blood Glucose; D007328:Insulin; D013488:Suppositories