Uterine and placental 5-HT profile in different gestational period of albino rats.
Possible role of 5-HT in pregnancy was investigated in albino rats by biological estimation of uterine and placental 5-HT contents in different periods of gestation in normal and drug treated rats. Uterine 5-HT level increased steadily from day-1 of gestation to reach the peak on day-7; thereafter, the level continued to decline throughout the period till day-20 when 5-HT level was lowest. From day-20, a mild secondary rise started and remained persistent even after parturition. The results show that a critical level of 5-HT in early gestational period is necessary for conception. Manipulation of endogenous 5-HT do not influence duration of gestation.
Acharya
S B
SB
Goswami
N G
NG
Debnath
P K
PK
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology; D004971:Estrus / Q000378:metabolism; D005260:Female; D010920:Placenta / Q000032:analysis* / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D013997:Time Factors; D014599:Uterus / Q000032:analysis* / Q000187:drug effects
D003533:Cyproheptadine; D012701:Serotonin; D004054:Diethylstilbestrol; D006916:5-Hydroxytryptophan