The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).
1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.
Cox
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School of Biological Sciences, National Institute for Higher Education, Dublin, Ireland.
O'Kennedy
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Thornes
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D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000503:physiopathology; D003374:Coumarins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D003374:Coumarins; D000410:Alanine Transaminase; D001663:Bilirubin