[Physiopathology of kinin forming system in reproduction].
We studied contact factors and kinin-kallikrein in normal non-pregnant and pregnant women, FXII deficient toxemia and DIC. The results obtained are as follows: 1. The levels of plasma prekallikrein, high molecular weight kininogen, kallikrein inhibitor, and C-1 INA were gradually decreased at delivery, and the levels of kallikrein like activity and bradykinin were increased during pregnancy and at the time of parturition. These facts indicate that kinin kallikrein systems played important role in uterine contraction. 2. The levels of contact factors (FXII and FXI) were lower at delivery than those of term. 3. In rat uterus, specific binding of bradykinin was observed by the method of radio receptor assay in the pelet of 10,000 X g fetal membranes, and its activity was 38%. 4. A synthetic kallikrein inhibitor (OS-291, MS) and bradykinin antagonist inhibited completely spontaneous uterine contraction of Wistar rats during delivery. 5. In the case of FXII deficiency, the levels of plasma prekallikrein, high molecular weight kininogen were normal, but at delivery, these levels were lower than those of term. The levels of kallikrein like activity which was half of normal parturition level was increased at parturition. 6. In cases of DIC (17) and severe toxemia (22), plasma prekallikrein levels were lower than the normal controls. The decrease was due to consumption of plasma prekallikrein to kallikrein activation.
Soga
K
K
Maki
M
M
Sasaki
T
T
Motoyama
Y
Y
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005172:Factor XI / Q000032:analysis; D005175:Factor XII Deficiency / Q000097:blood; D005260:Female; D006801:Humans; D007705:Kinins / Q000096:biosynthesis*; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D011288:Prekallikrein / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D007705:Kinins; D005172:Factor XI; D011288:Prekallikrein