The effect of exogenous glucocorticoids on blood adrenaline and noradrenaline during catecholaminemia induced by splanchnic nerve stimulation.
The effect of hydrocortisone (1 mg/kg) on the blood plasma adrenaline and noradrenaline levels was investigated in rabbits, dogs and cats during electrical stimulation (100 Hz at 80 V for 30 s) of adrenopetal segment of the splanchnic nerve. The administration of hydrocortisone increased the adrenaline retention in the circulation, which caused a significant elevation of its level in the blood plasma. In the experiments carried out on rabbits no significant difference between the effect of the same doses of corticosterone and hydrocortisone (1 mg/kg) on adrenaline level changes in the blood plasma were found.
Całkosiński
I
I
Department of Physiology, Medical Academy, Wrocław, Poland.
Switała
M
M
D000311:Adrenal Glands / Q000098:blood supply; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004558:Electric Stimulation; D004837:Epinephrine / Q000097:blood*; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013153:Splanchnic Nerves / Q000502:physiology*
D005938:Glucocorticoids; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine