Role of the mucus gel layer in the healing of acetic acid-induced gastric ulcers in rats.
Changes in the pH gradient and thickness of the mucus gel layer in the healing of acetic acid-induced gastric ulcers in rats were investigated. The maximum of the pH gradient and the thickness of mucus gel layer at the edge of ulcers and in the regenerated mucosa were higher, decreased gradually with the healing of the ulcers and finally reached normal values. This indicates that mucus and bicarbonate are secreted actively from the mucosa surrounding an ulcer and that they play an important role in protection of the base of ulcers and in acceleration of the healing of the ulcers.
Misaki
N
N
Research & Development Division, Grelan Pharmaceutical Co., Ltd., Tokyo, Japan.
Kawano
O
O
Uchida
M
M
Matsueda
K
K
Muraoka
A
A
Umeda
N
N
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D005782:Gels; D006863:Hydrogen-Ion Concentration; D008297:Male; D009093:Mucus / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors; D014945:Wound Healing
D000085:Acetates; D005782:Gels; D019342:Acetic Acid