Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.
Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. The results also suggest that noradrenaline receptors are present on a substantial percentage of all axon terminals in the cerebral cortex, despite the low density of noradrenergic fibers present. The data support the view that noradrenaline may serve a paracrine function.
Mobley
P
P
Greengard
P
P
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000187:drug effects*; D002540:Cerebral Cortex / Q000166:cytology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013237:Stereoisomerism; D016704:Synapsins
D009419:Nerve Tissue Proteins; D011943:Receptors, Adrenergic, beta; D016704:Synapsins; D007545:Isoproterenol; D015056:1-Methyl-3-isobutylxanthine; D009638:Norepinephrine