[Antipyrogenic properties of oxytocin].
Effects of oxytocin on pyrogenal or endogenous pyrogen-induced fever were studied. Intramuscular injection of oxytocin (0.2 micrograms/kg every half an hour) did not significantly affect the pattern of pyrogenal-induced fever. Constant intravenous injection of oxytocin (0.4 and 4 micrograms/kg/h) 2-4.5 h after pyrogenal decreased the rectal temperature, on an average, by 24% and 31%, respectively. Endogenous pyrogen fever was not attenuated by intravenous oxytocin (4 micrograms/kg/h). The antipyrogenic effect of oxytocin is related to inhibition of endogenous pyrogen synthesis rather than to blockade of its action, which is indicated by a decreased second peak of the temperature curve, inhibition of endogenous pyrogen synthesis in vitro, and persistence of the hyperthermic effect of endogenous pyrogen.
Murzenok
P P
PP
Kutsaeva
L F
LF
Zhitkevich
T I
TI
Gurin
V N
VN
D000818:Animals; D002478:Cells, Cultured; D005334:Fever / Q000188:drug therapy; D007273:Injections, Intramuscular; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011749:Pyrogens / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011817:Rabbits; D013997:Time Factors
D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D010121:Oxytocin
Antipirogennye svoĭstva oksitotsina.