Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart.
Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was marginally reduced by the antacid.
Barzaghi
N
N
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
Crema
F
F
Mescoli
G
G
Perucca
E
E
D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D000863:Antacids / Q000008:administration & dosage*; D001682:Biological Availability; D002927:Cimetidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage* / Q000494:pharmacology; D012841:Simethicone / Q000008:administration & dosage / Q000494:pharmacology
D000863:Antacids; D004338:Drug Combinations; C008570:aluminum hydroxide, magnesium hydroxide, simethicone drug combination; D000536:Aluminum Hydroxide; D002927:Cimetidine; D012841:Simethicone; D008787:Metoclopramide; D008276:Magnesium Hydroxide