Effects of pure interferons on Epstein-Barr virus infection in vitro.
Pure human gamma-interferon as well as alpha-interferon inhibited induction of immunoglobulin synthesis by Epstein-Barr virus but not by pokeweed mitogen in B lymphocytes from adult but not from newborn humans. The interferons inhibited the infected B lymphocytes directly, irrespective of the Epstein-Barr virus immune status of the donor, and their inhibitory effect was synergistic.
Andersson
J P
JP
Andersson
U G
UG
Ernberg
I T
IT
Britton
S F
SF
DeLey
M
M
D000956:Antigens, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000382:microbiology
D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D007075:Immunoglobulin M; D007372:Interferons