[The primary and secondary pathological changes in the brain in patients with epidemic hemorrhagic fever].
Pathological changes of brain in 12 patients died of epidemic hemorrhagic fever were analysed. Those cases having clinical history of hypotension and typical shock showed ischemic changes and necrosis of brain and its seguelae accompanying synchronous with infarct-like necrosis of the kidneys or pituitary gland (secondary change). One patient who died in the febrile stage showed scattered necrosis of nerve cells with neuronophagia (primary change). Immunocytochemical study on one recent case showed diffusely distributed positive virus antigen in neurons and glial cells of various kinds and even occasional positive reaction was seen in the nuclei.
Liu
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YF
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012769:Shock / Q000209:etiology