Autoantibodies against CD4- and CD8-positive T lymphocytes in HIV-infected hemophilia patients.
The presence of IgG, IgM, C3d, or gp120 on the surface of T lymphocytes was analyzed by flow cytometry in blood samples from 73 hemophilia patients and 56 healthy controls. IgG and IgM autoantibodies against CD4+ lymphocytes were found in HIV + patients but not in HIV-patients or healthy controls (p less than 0.001). IgM autoantibodies were more frequent than IgG autoantibodies. Autoantibody formation increased with disease progression. However, within the same disease risk category, patients with autoantibodies were not "more immunologically abnormal' than patients without autoantibodies. HIV + patients who possessed autoantibodies had similar CD4+ and CD8+ lymphocyte counts as HIV + patients without autoantibodies. There was no significant difference in the number of patients with abnormal CD4/CD8 ratios, serum neopterin levels, or in vitro responses to allogeneic stimulator cells or mitogens between autoantibody-positive or -negative patients of the same risk category. Our data suggest that autoantibodies against CD4+ lymphocytes may be helpful as indicators of disease progression, however, their immunopathogenetic role remains unclear.
Daniel
V
V
Department of Transplantation Immunology, University of Heidelberg, FRG.
Weimer
R
R
Schimpf
K
K
Opelz
G
G
D000386:AIDS-Related Complex / Q000097:blood / Q000150:complications / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis* / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000032:analysis / Q000276:immunology*; D015933:Complement C3d / Q000032:analysis; D015699:HIV Envelope Protein gp120 / Q000032:analysis; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications / Q000276:immunology*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D050378:T-Lymphocytes, Regulatory / Q000032:analysis / Q000276:immunology*
D001323:Autoantibodies; D015699:HIV Envelope Protein gp120; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015933:Complement C3d