Influence of CDP-choline administration on the aortic wall lesions in dietically hypercholesterolaemic rabbits: a morphometric evaluation.
In New Zealand rabbits subjected for a 2 month period to a 1% or 2% hypercholesterolic diet, larger intimal involvement and histologically heavier lesions were observed in the animals on a hypercholesterolic diet. The intimal involvement was larger in the aortic arch. In groups of rabbits simultaneously subjected to similar diets and to i.v. CDP-choline injections, the intimal involvement appeared reduced (p less than 0.01) both in the arch and in the descending tract of the thoracic aorta.
Weber
G
G
Centre for Research on Arteriosclerosis, University of Siena, Italy.
Auteri
A
A
Bianciardi
G
G
Fabrini
P
P
Resi
L
L
Salvi
M
M
Toti
P
P
Tanganelli
P
P
D000818:Animals; D001011:Aorta / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004032:Diet; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000150:complications*; D011817:Rabbits; D014652:Vascular Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D002791:Cholesterol, Dietary; D003566:Cytidine Diphosphate Choline; D002784:Cholesterol; D002794:Choline