Variations of sotalol kinetics in renal insufficiency.
Decreased elimination of sotalol (160 mg) is found in patients with renal insufficiency. Simulation of plasma concentrations at steady-state exhibits moderately higher concentrations when creatinine clearance is between 10 and 30 ml/min and very high plasma concentrations when creatinine clearance is less than 10 ml/min suggesting, if treatment is absolutely necessary, monitoring in these cases and the reduction of the dose in major renal insufficiency.
Dumas
M
M
Départment de Pharmacologie Clinique, Hopital Général, CHRU, Dijon, France.
d'Athis
P
P
Besancenot
J F
JF
Chadoint-Noudeau
V
V
Chalopin
J M
JM
Rifle
G
G
Escousse
A
A
D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D012307:Risk Factors; D013015:Sotalol / Q000097:blood / Q000493:pharmacokinetics*
D013015:Sotalol; D003404:Creatinine