Restriction fragment length polymorphisms of X chromosome among Japanese population.
Restriction fragment length polymorphisms were studied among the Japanese using 13 polymorphic DNA probes on the X chromosome. For 6 probes (pPA4B, cpX203, p58-1, pHPGK-7e, cpX289 and 7b) the allelic frequencies were the same as those for Caucasians, but they were quite different (p less than 0.01) for 4 probes (dic56, pOTC (MspI), pTAK8B and pXG-16 (HindIII)). No polymorphisms were observed for 4 probes (pG95 alpha 1-7dIII/RI (n (chromosome number studied) = 54), pXG-16 (TaqI) (n = 50, p8 (n = 108), and pXG-17 (n = 76). These results suggest that not a small number of DNA probes currently available are useless for linkage analysis in Japan.
Ueyama
H
H
Shirahase
W
W
Taga
T
T
Shimada
M
M
D015342:DNA Probes; D006801:Humans; D007564:Japan; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D015342:DNA Probes