Auto-erythrocyte sensitisation--the Gardner-Diamond syndrome. A case report.
A 34-year-old woman with a 3-year history of easy bruising of unexplained aetiology in anatomical sites consistent with self-infliction is described. Despite major surgery, the patient had never experienced inappropriate bleeding. Owing to psychological instability, the possibility of auto-erythrocyte sensitisation was considered; this was confirmed by subcutaneous injection of autologous red cells and haemolysate, which caused local tenderness and induration. This manifestation of Gardner-Diamond syndrome is unusual and is reported to draw attention to its existence and perhaps thereby avoid unnecessary and costly investigations.
Du Toit
J M
JM
University of Cape Town Leukaemia Centre.
Jacobs
P
P
Bird
A R
AR
Dickson
D N
DN
D000328:Adult; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D011693:Purpura / Q000209:etiology*; D013577:Syndrome
D007136:Immunoglobulins