title: Akathisia: selective beta-blockers and rating instruments.
abstract: beta-Blockers, particularly propranolol, have been shown to be an effective treatment for neuroleptic-induced akathisia (NIA). To examine the relative contribution of beta-1 and beta-2 receptor blockade to the therapeutic effect of propranolol, we studied a beta-1 selective agent (low dose metoprolol) and a beta-2 specific blocker (ICI 118,551). Both agents ameliorated NIA. To further evaluate instruments for quantifying NIA we compared (a) two sets of clinical ratings during the metoprolol study and (b) clinical and electromechanical ratings of NIA during the ICI 118,551 study. The changes in clinical ratings of NIA after metoprolol were similar for most patients; however, the changes in electromechanical and clinical ratings after ICI 118,551 were similar in less than half of the patients studied.
authors.forename: L A
authors.initials: LA
authors.lastname: Adler
authors.forename: E
authors.initials: E
authors.lastname: Duncan
authors.forename: A
authors.initials: A
authors.lastname: Kim
authors.forename: P
authors.initials: P
authors.lastname: Hemdal
authors.forename: J
authors.initials: J
authors.lastname: Rotrosen
authors.forename: B
authors.initials: B
authors.lastname: Angrist
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D014150:Antipsychotic Agents