Metoclopramide-induced parkinsonism.
Metoclopramide hydrochloride (Reglan) is a widely prescribed drug for treatment of upper gastrointestinal symptoms. Although the drug is relatively safe, a growing body of literature has noted movement disorders after its administration. We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period. Five of these six patients had renal failure. Their parkinsonism improved on discontinuation of metoclopramide therapy. Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.
Sethi
K D
KD
Department of Neurology, Medical College of Georgia, Augusta 30912-2366.
Patel
B
B
Meador
K J
KJ
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D013997:Time Factors
D008787:Metoclopramide