Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism.
Personal monitoring of 8-hour time-weighted average intensity of exposure with diffuse samplers and analysis of shift-end urine for total trichloro-compounds (TTC) and other metabolites were conducted in two groups of workers in China, one (121 subjects) exposed to tetrachloroethylene (TETRA) alone, and the other (38 subjects) exposed to a mixture of TETRA and trichloroethylene (TRI). Urinalysis was also performed on samples from 103 non-exposed controls. A linear exposure-excretion relationship could be observed in both groups of workers. Comparison of these results with those of Japanese TETRA-workers suggested the presence of ethnic difference in TETRA metabolism. Urinary metabolite levels were markedly lower in the mixed (TETRA + TRI) exposure group as compared to previous findings in a group exposed to TRI alone. The observation indicates that metabolism of TRI is suppressed by the co-exposure to TETRA in humans.
Seiji
K
K
Department of Environmental Health, Tohoku University School of Medicine, Sendai, Japan.
Inoue
O
O
Jin
C
C
Liu
Y T
YT
Cai
S X
SX
Ohashi
M
M
Watanabe
T
T
Nakatsuka
H
H
Kawai
T
T
Ikeda
M
M
D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis*; D002681:China; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D013750:Tetrachloroethylene / Q000652:urine*; D014241:Trichloroethylene / Q000652:urine*
D000395:Air Pollutants, Occupational; D014241:Trichloroethylene; D013750:Tetrachloroethylene