[A comparison of the spectra of antibodies to individual proteins of the human immunodeficiency virus in seropositive sera collected in the territories of the USSR and England].
Antibody spectra to individual proteins of human immunodeficiency virus (HIV) in 74 seropositive serum samples collected in the USSR and 65 serum samples collected in Britain were studied by immunoblotting techniques. Most of the sera belonged to clinically healthy persons, some of the sera collected in Britain contained specific IgM antibodies. The results were evaluated qualitatively and quantitatively. In the former case the study of samples collected both in the USSR and in Britain yielded similar results which also coincided with the data of literature regarding asymptomatic virus carriers: very high content of antibodies to protein gp41 and sufficiently high content of antibodies to protein p24 were registered in all sera. But the quantitative evaluation of the results of this investigation revealed differences between serum samples collected in these two countries. The main feature of sera collected in the USSR was their noticeably greater reactivity with respect to the products of HIV gene gag: proteins p24, p53 and p22. The explanations of this phenomenon are discussed.
Selimov
L M
LM
Berezin
V E
VE
Zaĭdes
V M
VM
Mortimer
P P
PP
D000328:Adult; D000349:Africa / Q000208:ethnology; D004739:England; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D014586:USSR; D015678:Viral Structural Proteins / Q000276:immunology*
D015483:HIV Antibodies; D007075:Immunoglobulin M; D015678:Viral Structural Proteins
Sravnenie spektrov antitel k individual'nym belkam virusa immunodefitsita cheloveka v seropozitivnykh syvorotkakh, sobrannykh na territorii SSSR i Anglii.