Cisplatin: nephrotoxic action in vertebrates and its prevention.
1. The kidney of frog and black sculpin appeared to be much less sensitive to the toxic action of CP in comparison with rat and pigeon. 2. The impairment of renal function after CP administration resulted in increased serum urea in rat, uric acid in pigeon and magnesium in black sculpin. 3. Kidney swelling is important feature of CP nephrotoxicity in rat and pigeon but not in frog and fish. 4. Pretreatment with choline chloride, PAH, furosemide and ethacrynic acid reduced the nephrotoxic action of CP in rat but did not prevent the accumulation of platinum in renal tissue which appeared to be a function of the dose injected to investigated animals.
Natochin YuV
Laboratory of Renal Physiology, USSR Academy of Sciences, Leningrad.
Reznik
L V
LV
Bakhteeva
V T
VT
Myazina
E M
EM
Brovtsyn
V K
VK
D000818:Animals; D002794:Choline / Q000627:therapeutic use; D002945:Cisplatin / Q000633:toxicity*; D010856:Columbidae; D004976:Ethacrynic Acid / Q000627:therapeutic use; D005260:Female; D005399:Fishes; D005665:Furosemide / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control; D008274:Magnesium / Q000097:blood; D010984:Platinum / Q000378:metabolism; D011896:Rana temporaria; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood; D010130:p-Aminohippuric Acid / Q000627:therapeutic use
D014527:Uric Acid; D010984:Platinum; D005665:Furosemide; D014508:Urea; D008274:Magnesium; D004976:Ethacrynic Acid; D002794:Choline; D002945:Cisplatin; D010130:p-Aminohippuric Acid