title: Complement C6 and C7 polymorphisms in Japanese patients with chronic glomerulonephritis.
abstract: C6 and C7 types were studied in 158 Japanese patients with different types of chronic glomerulonephritis: 75 patients with IgA nephropathy (IgA-N); 49 patients with idiopathic membranous nephropathy (IMN), and 34 patients with minimal-change nephrotic syndrome (MCNS). There were significant differences in the C6 and C7 allele and phenotype frequencies between the patient groups and controls. A strong association was found between IgA-N and C7 5 phenotype (p less than 0.001, RR = 12.71), and between MCNS and C7 5 phenotype (p less than 0.001, RR = 14.20). A significant association between MCNS and C6 B2 phenotype (p less than 0.05, RR = 2.42) was also found. In the IMN patient group, a significant association with C7 4 phenotype (p less than 0.05, RR = 2.42) was observed. Thus, C6 and C7 phenotypes may be causative factors in the development of chronic glomerulonephritis.
authors.affiliation: Department of Legal Medicine, School of Medicine, Ehime University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishimukai
authors.forename: I
authors.initials: I
authors.lastname: Nakanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: R
authors.initials: R
authors.lastname: Sumiyoshi
authors.forename: K
authors.initials: K
authors.lastname: Mizutani
authors.forename: N
authors.initials: N
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Shinomiya
mesh_terms: D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D005787:Gene Frequency; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D015433:Glomerulonephritis, Membranous / Q000235:genetics*; D006801:Humans; D007564:Japan; D009402:Nephrosis, Lipoid / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D003183:Complement C6; D003184:Complement C7