title: Characterization of activated peritoneal cells inhibiting the take of transplantable murine tumours.
abstract: We studied the properties of activated peritoneal cells (PC) inhibiting the take of SP4 spontaneous adenocarcinoma and Lewis lung carcinoma in syngeneic mice. Treatment of the poly I:C activated PC from Balb/c mice suppressing the take of SP4 tumour with anti-asialo GM1 antibody and complement before transfer did not affect their tumour-inhibitory potential. PC from Balb/c nude mice treated with poly I:C also inhibited the take of SP4 tumour. Spleen cells from untreated or poly I:C treated Balb/c and Balb/c nude mice, however, did not inhibit the take of SP4 adenocarcinoma. Treatment of peritoneal cells activated by a combination of poly I:C, indomethacin and Syncumar (referred to as "combined treatment") with anti-asialo GM1 antibody and complement could not, or could only partly abolish their tumour-inhibitory potential. The cells mediating the suppression of the take of Lewis lung tumour proved to be Thy-1,2+/-, Lyt-1-, Lyt 2.2- cells. We conclude that the activated peritoneal cells inhibiting the take of SP4 adenocarcinoma and Lewis lung tumour are different from NK cells, NC cells and LAK cells and represent a distinct antitumoural effector cell population.
authors.affiliation: National Institute of Hygiene, Microbiological Research Group, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Minárovits
authors.forename: E
authors.initials: E
authors.lastname: Karczag
authors.forename: I
authors.initials: I
authors.lastname: Földes
mesh_terms: D000074:Acenocoumarol / Q000494:pharmacology; D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D002277:Carcinoma / Q000276:immunology*; D003165:Complement System Proteins / Q000494:pharmacology; D005260:Female; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000276:immunology; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000166:cytology*; D011070:Poly I-C / Q000494:pharmacology
chemical_list: D000906:Antibodies; D006028:Glycosphingolipids; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D003165:Complement System Proteins; D000074:Acenocoumarol; D011070:Poly I-C; D007213:Indomethacin