title: Conservative management of testicular endodermal sinus tumor in childhood.
abstract: Endodermal sinus tumor is the most common testicular neoplasm in childhood. The management of children with this neoplasm remains controversial. We have treated prospectively 5 children with stage I endodermal sinus tumor with limited surgery and no adjuvant therapy. The median patient age at diagnosis was 21 months (range 5 to 24 months). All children underwent an inguinal orchiectomy with high ligation of the spermatic cord. Retroperitoneal node dissection was not performed in any case and no child received adjuvant chemotherapy or radiation therapy. All patients were well without evidence of recurrent disease at a median followup of 46 months (range 19 to 72 months). Because these tumors usually are localized at the time of diagnosis, rarely spread to the retroperitoneal nodes and have a biological marker in most cases, and because good salvage chemotherapy is available for patients with relapse, we believe that nonmetastatic testicular endodermal sinus tumors in children can be managed with radical orchiectomy alone. Retroperitoneal node dissection is not necessary and adjuvant therapy is not indicated if markers return to normal. Further treatment should be reserved for the rare child with relapse.
authors.forename: W L
authors.initials: WL
authors.lastname: Carroll
authors.forename: R L
authors.initials: RL
authors.lastname: Kempson
authors.forename: D E
authors.initials: DE
authors.lastname: Govan
authors.forename: F S
authors.initials: FS
authors.lastname: Freiha
authors.forename: S J
authors.initials: SJ
authors.lastname: Shochat
authors.forename: M P
authors.initials: MP
authors.lastname: Link
mesh_terms: D002369:Castration; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000032:analysis; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006801:Humans; D007223:Infant; D008297:Male; D008649:Mesonephroma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010446:Peptide Fragments / Q000032:analysis; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D000509:alpha-Fetoproteins