Clinical significance of a solid-phase immunoradiometrical assay for sialyl SSEA-1 antigen in obstetrics and gynecology.
The clinical usefulness of sialyl SSEA-1 antigen was evaluated in obstetrics and gynecology. Serum levels of sialyl SSEA-1 were measured in patients with benign or malignant gynecologic diseases, and in normal pregnant women. Moreover, in 10 cases of full term delivery, samples of maternal sera immediately prior to delivery, soon after delivery and 5-day-puerperium, cord sera from the umbilical artery and vein, and amniotic fluid were taken to measure its concentration. During the course of pregnancy, serum SSEA-1 levels were within the normal range (below 38 U/ml), showing no significant correlation with gestational weeks. Of patients with gynecologic diseases, those with malignant ovarian neoplasms, uterine cervical carcinoma and benign ovarian neoplasms exhibited elevated (over 38 U/ml) levels in 26%, 15% and 6% of all cases, respectively. In cases of full term delivery, the concentrations of sialyl SSEA-1 in the maternal and cord sera were within the normal range. Concentrations were extremely high, however, in the amniotic fluid.
Ota
Y
Y
Inaba
N
N
Shirotake
S
S
Fukazawa
I
I
Okajima
Y
Y
Takamizawa
H
H
D000653:Amniotic Fluid / Q000032:analysis / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000302:isolation & purification; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology*; D006801:Humans; D011247:Pregnancy; D011863:Radioimmunoassay; D011874:Radiometry
D000951:Antigens, Neoplasm