Conserved residues of tumour necrosis factor and lymphotoxin constitute the framework of the trimeric structure.
Four distinct areas of primary sequence conservation between known tumour necrosis factor and lymphotoxin polypeptides from various species can be recognized. When these amino acid sequences are highlighted in the three-dimensional structure, all are found in the same region, constituting the framework of the trimeric structure.
Tavernier
J
J
Roche Research Gent, Belgium.
van Ostade
X
X
Hauquier
G
G
Prange
T
T
Lasters
I
I
de Maeyer
M
M
Lewit-Bentley
A
A
Fourme
R
R
D000595:Amino Acid Sequence; D000818:Animals; D003196:Computer Graphics; D003461:Crystallography; D006801:Humans; D008233:Lymphotoxin-alpha; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha
D008233:Lymphotoxin-alpha; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha