Short-term effects of temazepam in the EEGs of healthy volunteers.
In this study effects of temazepam on the EEGs of 10 healthy volunteers were detected using a standardized EEG registration procedure applied in a controlled environment. The EEGs were recorded both before and after administration of 20 mg temazepam as well as before and after placebo. A mean power spectrum was computed for each EEG from the 'eyes closed' condition, and the Student t test was used to detect differences in the spectra of the pre- and posttreatment EEGs in both placebo and drug conditions. For all 10 subjects the drug condition was easily distinguishable from the placebo condition based on the results of the t test.
Janssen
F H
FH
Department of Clinical Neurophysiology, Epilepsy Center, Kempenhaeghe, Heeze, The Netherlands.
Beecher
L
L
Griep
P A
PA
Declerck
A C
AC
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D012815:Signal Processing, Computer-Assisted; D013693:Temazepam / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D013693:Temazepam