title: A multipoint linkage map around the locus for myotonic dystrophy on chromosome 19.
abstract: Employing 16 polymorphic DNA markers as well as the chromosome 19 centromere heteromorphism, we have performed a genetic linkage study in 26 families with myotonic dystrophy. Fourteen of these markers had been assigned previously to one of five different intervals of the 19cen-19q13.2 segment by using somatic cell hybrids. For the long arm of chromosome 19, a genetic map that encompasses 9 polymorphic markers and the DM gene has been constructed. Our studies indicate that the DM and CKMM genes map distal to the ApoC2-ApoE gene cluster and to the anonymous polymorphic markers D19S15 and D19S16, but proximal to the D19S22 marker. The orientation of DM and CKMM remains to be determined.
authors.affiliation: Department of Human Genetics, University Hospital, 6500HB Nijmegen, The Netherlands.
authors.forename: H G
authors.initials: HG
authors.lastname: Brunner
authors.forename: H
authors.initials: H
authors.lastname: Smeets
authors.forename: H M
authors.initials: HM
authors.lastname: Lambermon
authors.forename: M
authors.initials: M
authors.lastname: Coerwinkel-Driessen
authors.forename: B A
authors.initials: BA
authors.lastname: van Oost
authors.forename: B
authors.initials: B
authors.lastname: Wieringa
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003434:Crossing Over, Genetic; D004252:DNA Mutational Analysis; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers