[The effect of pH and pO2 changes in the blood on the energy metabolism of human erythrocytes in old age].
Changes in pH and pO2 of the blood have been studied for age peculiarities of their effect on the glycolysis rate and the content of ATP and 2,3-diphosphoglycerate (2,3-DPG) in erythrocytes (in vitro). The fresh venous blood of practically healthy young (aged 20-29) and old (aged 75-85) people was used. Acidosis was shown to induce inhibition of glycolysis and decrease of the ATP and 2.3-DPG concentrations in erythrocytes, while alkalosis and hypoxemia-an increase of the glycolysis rate and 2.3-DPG content. In the both cases changes in the indices studied were considerably lower in old people as compared to young ones.
Bogatskaia
L N
LN
Pisaruk
A V
AV
D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood; D004734:Energy Metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*
D004163:Diphosphoglyceric Acids; D000255:Adenosine Triphosphate; D010100:Oxygen
Vliianie izmeneniĭ pH i pO2 krovi na énergeticheskiĭ obmen éritrotsitov cheloveka v starosti.