title: [In vitro models for research on cell differentiation and malignant degeneration in the human prostate].
abstract: The methods are reviewed for obtaining monolayer epithelium cultures both in normal and hyperplastic or malignant prostate glands. Preparation of pure epithelial tissue cultures is dealt with in detail. The major prostate cell lines are described. Special attention is paid to the markers of differentiation and sensitivity to hormones in normal and tumour prostatic cells in vitro. Prospects for the use of prostatic cell cultures as models in oncology are outlined.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Bozhok
authors.forename: S S
authors.initials: SS
authors.lastname: Kireeva
authors.forename: S V
authors.initials: SV
authors.lastname: Varga
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000328:Adult; D000728:Androgens / Q000494:pharmacology; D000941:Antigens / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology*; D002478:Cells, Cultured; D003470:Culture Media / Q000494:pharmacology; D003584:Cytological Techniques; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D005786:Gene Expression Regulation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D000728:Androgens; D000941:Antigens; D003470:Culture Media; D000135:Acid Phosphatase
vernacular_title: Modeli in vitro dlia izucheniia differentisirovki i malignizatsii kletok predstatel'noĭ zhelezy cheloveka.