Treatment of experimental disseminated candidiasis with cilofungin.
The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. Cilofungin treatment reduced yeast counts, especially in the kidney, with activity comparable to that of amphotericin B. The peak level of cilofungin in serum was measured at 5 min after administration of a single dose, with no drug detectable after 90 min.
Perfect
J R
JR
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Hobbs
M M
MM
Wright
K A
KA
Durack
D T
DT
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D054714:Echinocandins; D066298:In Vitro Techniques; D008297:Male; D010455:Peptides / Q000627:therapeutic use; D010456:Peptides, Cyclic; D011817:Rabbits
D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; C042101:cilofungin