title: Role of testosterone in regulating the growth of mice from lines selected for low vs high plasma insulin-like growth factor-I concentrations.
abstract: A study was undertaken to investigate the role of testosterone in regulating growth and circulating levels of insulin-like growth factor-I in male mice from lines divergently selected on the basis of plasma IGF-I. Controls of each lines were sham-operated at 10 days of age and treated with peanut oil from day 14 to day 70. A second group, which was castrated at 10 days and treated with testosterone enanthate (0.5 micrograms.(g body weight)-1.day-1) from day 14 to 70, did not differ from controls in body weight but had higher plasma IGF-I concentrations. Delaying testosterone therapy until day 42 in a third group retarded growth, with body weights being significantly lower than those of other two groups from days 35 to 56. However, plasma IGF-I levels in this group were not different from those of controls. Effects of line and treatment were additive. It is concluded that the greater pubertal growth of high-line compared to low-line males is not due to greater stimulation of circulating IGF-I by testosterone. Furthermore, testosterone does not appear to influence pubertal growth by acting on circulating levels of IGF-I.
authors.affiliation: Department of Animal Science, Massey University, Palmerston, New Zealand.
authors.forename: R A
authors.initials: RA
authors.lastname: Siddiqui
authors.forename: S N
authors.initials: SN
authors.lastname: McCutcheon
authors.forename: D D
authors.initials: DD
authors.lastname: Mackenzie
authors.forename: H T
authors.initials: HT
authors.lastname: Blair
authors.forename: J E
authors.initials: JE
authors.lastname: Ormsby
authors.forename: P D
authors.initials: PD
authors.lastname: Gluckman
authors.forename: B H
authors.initials: BH
authors.lastname: Breier
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009919:Orchiectomy; D000074241:Peanut Oil; D010938:Plant Oils / Q000008:administration & dosage; D012741:Sexual Maturation / Q000187:drug effects*; D013002:Somatomedins / Q000276:immunology*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000074241:Peanut Oil; D010938:Plant Oils; D013002:Somatomedins; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; C004648:testosterone enanthate