title: Pulmonary vasoconstrictor overreactivity in borderline systemic hypertension.
abstract: Raised vascular pressure and resistance and vasoconstrictor overreactivity to adrenergic stimulation are hallmarks of the pulmonary circulation in sustained primary hypertension. The aim of this study was to investigate the reasons for these disorders. In 10 males with borderline systemic hypertension, pulmonary haemodynamic variables were similar to those of an age matched group of eight normotensive subjects. In normotension, arithmetic and cold pressor tests (sympathetic activators) caused slight vasodilatation and vasoconstriction, respectively. In hypertension both tests showed an obvious vasoconstrictor effect. Restriction of blood flow through the lungs by distension of a balloon in the inferior vena cava is known to increase pulmonary vasoconstrictor reactivity in normal man. As a result of this manoeuvre, pulmonary pressure fell in the normotensive controls without variation in pulmonary vascular resistance, whereas in the hypertensive group there was an increase in resistance and the pressure did not change. In normotensive subjects with caval balloon, the sympathetic activating stimuli both became constrictor and caused vascular resistance to rise to the levels attained in the hypertensive patients during adrenergic stimulation in the absence of obstruction to venous return. In the hypertensives, these stimuli were not able to enhance the pulmonary vascular resistance further. This shows that in these patients maximal vasoconstriction was already achieved through the simple restraint of blood flow with vena caval obstruction. We suggest that in the early phases of systemic hypertension lung vessels are hypercontractile so that they overreact to hypoperfusion or to sympathetic stimulation, even before there is a stable rise in pressure and resistance.
authors.affiliation: Istituto di Cardiologia, Centro Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, University of Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Moruzzi
authors.forename: P
authors.initials: P
authors.lastname: Sganzerla
authors.forename: M D
authors.initials: MD
authors.lastname: Guazzi
mesh_terms: D000328:Adult; D002302:Cardiac Output; D002395:Catecholamines / Q000097:blood; D002404:Catheterization; D002405:Catheterization, Central Venous; D003080:Cold Temperature; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D011652:Pulmonary Circulation; D013315:Stress, Psychological / Q000503:physiopathology; D014655:Vascular Resistance; D014661:Vasoconstriction; D014682:Vena Cava, Inferior
chemical_list: D002395:Catecholamines