[Characteristics of enzyme induction in the liver monooxygenase system of rabbits intravenously administered a fluorocarbon emulsion].
Intravenous injections to rabbits of perfluorocarbon emulsion containing perfluorodecaline (10 ml/kg, equivalent to 1.3 g of perfluorodecaline per 1 kg of body weight) produced a 2-4-fold increase of cytochrome P-450 content in the liver microsomes within 3-4 weeks. Cytochrome P-450 induction was followed by activation of the liver monoxygenase system evaluated by the rate of antipyrine excretion from the blood. On the 1st day after administration perfluorodecaline caused an insignificant (14%) inhibition of the monoxygenase system.
Obraztsov
V V
VV
Sklifas
A A
AA
Kukushkin
N I
NI
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics; D001802:Blood Substitutes / Q000008:administration & dosage / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004655:Emulsions; D004790:Enzyme Induction / Q000187:drug effects; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D006207:Half-Life; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000096:biosynthesis*; D011817:Rabbits
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D000983:Antipyrine
Osobennosti induktsii fermentov monooksigenaznoĭ sistemy pecheni krolikov pri vnutrivennom vvedenii ftoruglerodnoĭ émul'sii.