title: Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months.
abstract: To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunisation. For the 55% of children who were seronegative before vaccination at age 4-5 months seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. Seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccination with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months was as good as vaccination with the AIK-C strain at 8-10 months and better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that the administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months.
authors.affiliation: CHU, Lomé, Togo.
authors.forename: O
authors.initials: O
authors.lastname: Tidjani
authors.forename: B
authors.initials: B
authors.lastname: Grunitsky
authors.forename: N
authors.initials: N
authors.lastname: Guérin
authors.forename: D
authors.initials: D
authors.lastname: Lévy-Bruhl
authors.forename: N
authors.initials: N
authors.lastname: Lecam
authors.forename: C
authors.initials: C
authors.lastname: Xuereff
authors.forename: K
authors.initials: K
authors.lastname: Tatagan
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine