[Macrolide-theophylline interaction. Experiences in pediatrics].
Subjects suffering from bronchial asthma being treated with theophylline often have to be treated with an antibiotic during acute stages. The purpose of the present study is to assess to clearance variation in theophylline when a macrolide antibiotic is associated after theophyllinemia steady-state has been attained. It has been seen that macrolides interfere differently on the blood levels of theophylline. Whereas erythromycin and josamycin determine a significant reduction in theophylline clearance, Miocamycin seems not to modify this parameter significantly.
Pavesio
D
D
Mora
P
P
Leone
L
L
Moresco
V
V
Girardo
G
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy; D001499:Bayes Theorem; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D004917:Erythromycin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015570:Josamycin / Q000494:pharmacology / Q000627:therapeutic use; D008657:Metabolic Clearance Rate; D015644:Miocamycin / Q000494:pharmacology / Q000627:therapeutic use; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D015644:Miocamycin; D004917:Erythromycin; D013806:Theophylline; D015570:Josamycin
Interazione macrolidi-teofillina. Esperienze in pediatria.