title: [The role of protein phosphorylation in mast cell secretion, stimulated by concanavalin A. Connection to the cytoskeleton].
abstract: The role of cytoskeleton and protein phosphorylation in concanavalin A and phorbol ester (PMA) induced mast cell secretion was investigated. It was shown that the receptor coupled with lectin interacts with the cytoskeleton. When the ligand-receptor complex is formed, an increased phosphorylation of some proteins is induced. The same proteins are phosphorylated under the influence of PMA, a protein kinase C activator, thus suggesting that protein kinase C is involved in the regulation of mast cell exocytosis. The results obtained testify to the effect that the mechanism of mast cell degranulation induced by concanavalin A is due to modification of the cytoskeleton.
authors.forename: N O
authors.initials: NO
authors.lastname: Dulin
authors.forename: E N
authors.initials: EN
authors.lastname: Goncharenko
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kudriashov
authors.forename: E E
authors.initials: EE
authors.lastname: Graevskaia
authors.forename: G M
authors.initials: GM
authors.lastname: Kravtsov
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D003599:Cytoskeleton / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D005453:Fluorescence; D006632:Histamine / Q000032:analysis; D007700:Kinetics; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010703:Phorbol Esters / Q000494:pharmacology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats
chemical_list: D010703:Phorbol Esters; D011506:Proteins; D003208:Concanavalin A; D006632:Histamine; D011493:Protein Kinase C
vernacular_title: Rol' fosforilirovaniia belkov v sekretsii tuchnykh kletok, stimulirovannykh konkavalinom A. sviaz' s tsitoskeletom.