title: [Isoenzymes of human blood cholinesterases and their genetic control].
abstract: Acetylcholinesterase from human erythrocytes solubilized by 1% Triton X-100 was resolved using polyacrylamide gel electrophoresis into two components. The first one (fast) is more firmly bound to cell membranes than the other. The existence of multiple forms (C1-C4) of serum cholinesterase-1 (CHE1) has been established. Electrophoresis in acid medium (pH 4.8) permits to detect the C5 component and a group of supplementary isoenzymes of cholinesterase-2. Individual differences observed in patterns of the CHE2 isozymes are controlled by a pair of autosomal codominant alleles Che2A and Che2B. The serum of subjects with phenotypes Che2AB(C5+) and Che2BB(C5-) showed on the average equal level of cholinesterase activity.
authors.forename: P N
authors.initials: PN
authors.lastname: Shubin
authors.forename: E A
authors.initials: EA
authors.lastname: Efimtseva
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000235:genetics*; D000483:Alleles; D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D000110:Acetylcholinesterase; D002802:Cholinesterases
vernacular_title: Izofermenty kholinésteraz krovi cheloveka i ikh geneticheskiĭ kontrol'.