title: [The stimulating effect of N-nitroso-ethylurea on the biosynthetic ability of Aspergillus oryzae].
abstract: The mutagenic action of N-nitroso-N-ethylurea (NEU) taken at shock and prolonged doses together on Aspergillus oryzae yielded 98% of populations with an elevated synthesis of proteolytic enzymes. The combined action of shock and prolonged NEU doses had an advantage over a shock pulse dose because the frequency of mutations rose 2-16 times and the populations accumulated proteolytic enzymes within the range of 9 to 24 activity units. As was shown using a certain number of populations selected at random, the elevated accumulation of proteolytic enzymes in the medium remained stable within eight generations.
authors.forename: V A
authors.initials: VA
authors.lastname: Khamidulin
authors.forename: N S
authors.initials: NS
authors.lastname: Landau
authors.forename: N S
authors.initials: NS
authors.lastname: Egorov
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D001236:Aspergillus oryzae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005798:Genes, Bacterial; D006868:Hydrolysis; D009153:Mutagens; D013268:Stimulation, Chemical
chemical_list: D009153:Mutagens; D005038:Ethylnitrosourea
vernacular_title: Stimuliruiushchee deĭstvie n-nitrozo-N-étilmocheviny na biosinteticheskuiu sposobnost' Aspergillus oryzae.