Complement-dependent cytotoxicity of antibodies reactive with HIV-induced cell surface antigens in HIV-carrying haemophiliacs.
Sera obtained from HIV-infected as well as uninfected haemophiliacs and from healthy subjects were investigated for the presence of lymphocytotoxic antibodies. Using the 51Cr-release test, HIV-infected haemophiliacs were found to produce serum antibodies exerting complement-dependent cytotoxic effect on HIV-infected T4 cells. The antibodies were reactive mainly when HIV-infected target cells were stimulated with concanavalin-A. Results of complement-dependent antibody cytotoxicity and indirect membrane immunofluorescence tests suggest that envelope antigen(s) of HIV may be the target(s) for cytotoxic antibodies.
Tóth
F D
FD
Institute of Microbiology, Medical University, Debrecen, Hungary.
Kiss
J
J
Szabó
B
B
Füst
G
G
Ujhelyi
E
E
Hollán
S R
SR
Váczi
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D015938:Complement Membrane Attack Complex; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000032:analysis*; D015488:HIV Antigens / Q000276:immunology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology
D000954:Antigens, Surface; D015938:Complement Membrane Attack Complex; D015483:HIV Antibodies; D015488:HIV Antigens