[Calcium release from the intracellular stores of the soma of the mollusk neuron under the action of inositol triphosphate and its nonhydrolyzable analog GTP].
The effects of intracellularly injected inositol trisphosphate (IP3) and nonhydrolyzed GTP analogue (Gpp[NH]p) on intracellular concentration of calcium ions [Ca2+]in was determined by fluorescence signals obtained from Helix pomatia neurons. At the same time these neurons were studied under the current clamp conditions. The IP3 and Gpp[NH]p injection caused a long-lasting [Ca2+]in increase in all neurons. Removal of the Ca2+ ions from external solution did not change the [Ca2+]in values. It is suggested that there is IP3- and GTP-dependent release of Ca2+ from intraneuronal stores in the Helix pomatia neurons.
Belan
P V
PV
Osipenko
O N
ON
Tepikin
A V
AV
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000494:pharmacology*; D006372:Helix, Snails; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology*; D008845:Microinjections / Q000379:methods; D008974:Mollusca / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*
D015544:Inositol 1,4,5-Trisphosphate; D006160:Guanosine Triphosphate; D002118:Calcium
Osvobozhdenie kal'tsiia iz vnutrikletochnykh depo somy neĭrona molliuska pod deĭstviem inozitoltrifosfata i negidrolizuemogo analoga GTF.