Fatal variceal haemorrhage after paracetamol overdose.
A patient is described where oesophageal varices developed and bled 13 days after a paracetamol overdose. The bleeding was unresponsive to medical management and proved fatal. There was no evidence that the patient had pre-existing liver disease. At necropsy the liver showed severe acute parenchymal necrosis but chronic lesions were absent. The portal vein and hepatic veins were patent.
Thornton
J R
JR
Department of Medicine, St James's University Hospital, Leeds.
Losowsky
M S
MS
D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D062787:Drug Overdose / Q000150:complications; D004932:Esophageal and Gastric Varices / Q000139:chemically induced*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male
D000082:Acetaminophen