Suppression of immediate skin tests by ranitidine.
The suppression of immediate skin reactions to histamine and compound 48/80 by ranitidine, 150 mg every 12 hours for seven doses, was determined in a double-blind study in 23 subjects. Ranitidine compared to placebo produced a 22% suppression of the wheal-and-flare response to histamine (p less than 0.05) but only a 4% suppression of the wheal and flare with compound 48/80 (not significant). Although the suppression of the histamine skin test was statistically significant, this degree of suppression may be of limited clinical significance in allergy diagnostic testing.
Miller
J
J
University of Colorado Health Sciences Center, Denver.
Nelson
H S
HS
D000328:Adult; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D012882:Skin Tests; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D011899:Ranitidine