Comparison of three cardioplegic solutions during hypothermic ischemic arrest in neonatal blood-perfused rabbit hearts.
Inadequate myocardial preservation continues to be an important cause of postoperative morbidity and mortality after pediatric cardiac operations. To investigate methods of improving preservation in neonatal myocardium, we compared three cardioplegic solutions with topical hypothermia during 120 minutes of ischemic arrest in isolated, blood-perfused, neonatal rabbit hearts. Topical hypothermia (15 degrees C) without cardioplegia resulted in 71% +/- 5% recovery of preischemic contractile function. A high potassium (30 mEq/L) cardioplegic solution resulted in a 76% +/- 6% recovery of function, not significantly different from that obtained with hypothermia alone. In contrast, the St. Thomas' Hospital and Hôpital Lariboisiere cardioplegic solutions resulted in recoveries of 89% +/- 6% and 88% +/- 7%, respectively, both of which were significantly greater (p less than 0.001) than recoveries obtained with the high potassium solution or hypothermia alone. Thus the cardioplegic solutions used at St. Thomas' Hospital and Hôpital Lariboisiere provided excellent protection during 2 hours of hypothermic ischemic arrest in neonatal rabbit hearts and resulted in functional recovery superior to that achieved with hypothermia alone or with the high potassium cardioplegic solution.
Konishi
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Cardiovascular Institute, Boston University School of Medicine, MA 02118.
Apstein
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CS
D000818:Animals; D000831:Animals, Newborn; D001639:Bicarbonates / Q000008:administration & dosage; D002122:Calcium Chloride / Q000008:administration & dosage; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D003326:Coronary Circulation; D005260:Female; D006321:Heart / Q000503:physiopathology; D006324:Heart Arrest, Induced; D008274:Magnesium / Q000008:administration & dosage; D008297:Male; D009200:Myocardial Contraction; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D011188:Potassium / Q000008:administration & dosage; D011189:Potassium Chloride / Q000008:administration & dosage; D017680:Potassium Compounds; D011817:Rabbits; D012965:Sodium Chloride / Q000008:administration & dosage
D001639:Bicarbonates; D002314:Cardioplegic Solutions; D017680:Potassium Compounds; C041711:St. Thomas' Hospital cardioplegic solution; C018369:potassium cardioplegic solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride; D011188:Potassium