title: The effect of sufentanil on intracranial pressure (ICP) in anesthetized dogs.
abstract: The use of sufentanil in neuroanesthesia has been questioned because of a potential increase in intracranial pressure (ICP) in dogs and humans. The effect of sufentanil administration on ICP was studied in 6 dogs with normal and elevated baseline ICP, anesthetized with nitrous oxide and an intravenous piritramide infusion. No significant change in ICP could be demonstrated over a 30 minute observation period after administration of 2 micrograms/kg of sufentanil. The results indicate that this dose of sufentanil does not increase ICP in moderately hyperventilated dogs under stable anesthetic conditions.
authors.affiliation: Department of Anesthesiology, Katholieke Universiteit Leuven, University Hospitals, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Van Hemelrijck
authors.forename: M
authors.initials: M
authors.lastname: Mattheussen
authors.forename: R
authors.initials: R
authors.lastname: Wüsten
authors.forename: T
authors.initials: T
authors.lastname: Lauwers
authors.forename: H
authors.initials: H
authors.lastname: Van Aken
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000768:Anesthesia, General; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007427:Intracranial Pressure / Q000187:drug effects*; D017409:Sufentanil
chemical_list: D000701:Analgesics, Opioid; D017409:Sufentanil; D005283:Fentanyl