The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity.
The c-fms proto-oncogene is a member of a gene family that has been implicated in tumorigenesis. Glycoproteins encoded by c-fms were identified in cat spleen cells by means of an immune-complex kinase assay performed with monoclonal antibodies to v-fms-coded epitopes. The major form of the normal cellular glycoprotein has an apparent molecular weight of 170,000 and, like the product of the viral oncogene, serves as a substrate for an associated tyrosine-specific protein kinase activity in vitro. The results suggest that the transforming glycoprotein specified by v-fms is a truncated form of a c-fms-coded growth factor receptor.
Rettenmier
C W
CW
Chen
J H
JH
Roussel
M F
MF
Sherr
C J
CJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002415:Cats; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009857:Oncogenes; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases; D000090063:Proto-Oncogene Mas; D012313:RNA / Q000378:metabolism; D051381:Rats
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D012313:RNA; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases