The effects of QX314 on thalamic neurons.
The effects of QX314 were studied in cat thalamic neurons recorded in vivo. Besides blocking Na+ spike electrogenesis, QX314 transformed spindle oscillations into a single long-lasting period of hyperpolarization that terminated with a rebound Ca2+ spike. Large sustained injections of the drug resulted in the occurrence of numerous fast prepotentials that had the characteristics of attenuated dendritic Ca2+ spikes. These effects are interpreted as resulting from the blockage by QX314 of a persistent Na+ current and a delayed rectifier K+ current which currents have already been disclosed in thalamic neurons recorded in vitro.
Mulle
C
C
Steriade
M
M
Deschênes
M
M
D000818:Animals; D002118:Calcium / Q000502:physiology; D002415:Cats; D007473:Ion Channels / Q000187:drug effects*; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology
D007473:Ion Channels; C012647:QX-314; D008012:Lidocaine; D012964:Sodium; D011188:Potassium; D002118:Calcium