[Blockers of the uncoupling action of caffeine on the Ca2+-transport function of sarcoplasmic reticulum membranes].
The influence of caffeine on the efficiency of Ca2+ transport in the presence of oxalate by different fractions of sarcoplasmic reticulum (SR) membranes from rabbit skeletal muscle was studied. It was shown that caffeine (5 mM) decreases 4-fold the value of the Ca/ATP ratio in terminal cisterns of the SR without having any appreciable influence on the efficiency of Ca2+ transport by the light fraction of the SR. The uncoupling effect of caffeine is completely blocked by ruthenium red and by the local anesthetics, tetracaine, procaine, and benzocaine.
Ritov
V B
VB
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002110:Caffeine / Q000037:antagonists & inhibitors*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D012430:Ruthenium Red / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D014475:Uncoupling Agents / Q000037:antagonists & inhibitors*
D000779:Anesthetics, Local; D014475:Uncoupling Agents; D012430:Ruthenium Red; D002110:Caffeine; D000252:Calcium-Transporting ATPases; D002118:Calcium
Blokatory razobshchaiushchego deĭstviia kofeina na Ca2+-transporti-ruiushchuiu funktsiiu membran sarkoplazmaticheskogo retikuluma.