[A model of the isolated blood perfused lung of rats in testing hypoxic pulmonary vasoconstriction].
Comparing two variants of models (in situ, ex situ) of the isolated blood-perfused rat lung for measurement of the hypoxic pulmonary vasoconstriction the in situ preparation gave better results. The optimal severity of hypoxia was 2% O2 in intervals (hypoxia and normoxia, respectively) of seven minutes. The model works sufficiently for two hours.
Brandt
R
R
Forschungsinstitut für Lungenkrankheiten und Tbk Berlin/DDR.
Oddoy
A
A
Böhnke
J
J
Schilling
W
W
D000818:Animals; D000860:Hypoxia / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D010477:Perfusion; D011651:Pulmonary Artery / Q000503:physiopathology; D011652:Pulmonary Circulation; D011669:Pulmonary Wedge Pressure; D051381:Rats; D014661:Vasoconstriction
Das Modell der isolierten blutperfundierten Lunge von Ratten zur Testung der hypoxischen pulmonalen Vasokonstriktion.