Calcium antagonists. Pharmacologic differences and similarities.
The available calcium antagonists fall into these broad classes: the dihydropyridines, the benzothiazepines, and the phenylalkylamines. Although they all inhibit calcium entry into cells, the drugs differ in their pharmacodynamic and pharmacokinetic properties. The pharmacodynamic differences arise from the drugs' differing potencies in different tissues and resultant variability in the reflex effects elicited by the drugs' primary effects.
Wood
A J
AJ
Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Nashville, TN 37232.
D002121:Calcium Channel Blockers / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects
D002121:Calcium Channel Blockers