Human alpha- and beta-calcitonin gene-related peptides are vasodilators in human chorionic plate vasculature.
Calcitonin gene-related peptide receptors are known to be present in the placenta. We studied the effect of alpha- or beta-calcitonin gene-related peptide or carrier on human chorionic plate arteries preconstricted with angiotensin II. Both forms of calcitonin gene-related peptides evoked dose-dependent relaxation, the magnitude of which was proportional to the initial response to angiotensin II.
Firth
K F
KF
Department of Obstetrics and Gynecology, University Hospital, Nottingham, England.
Broughton Pipkin
F
F
D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002823:Chorion / Q000098:blood supply*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D015740:Calcitonin Gene-Related Peptide