title: The identification, localization, and pharmacology of FMRFamide-related peptides and SCPB in the penis and crop of the terrestrial slug, Limax maximus.
abstract: 1. The molluscan neuropeptides FMRFamide, pQDPFLRFamide, and SCPB were tested on the isolated crop and penis of the terrestraial slug, Limax maximus. FMRFamide and pQDPFLRFamide stimulated the penis and inhibited contractions of the crop. In contrast, SCPB either stimulated or relaxed the penis and increased the tone of the crop. 2. Fibers and varicosities containing immunoreactive (ir-) FMRFamide and ir-SCPB were located in the penis and crop. 3. Extracts of penes, crops, ganglia, and whole animals all contained FMRFamide, FLRFamide, SDPFLRFamide, NDPFLRFamide, and pQDPFLRFamide. 4. These results suggest that the FMRFamide-related peptides and SCPB are involved in the regulation of the reproductive and digestive activities of Limax.
authors.affiliation: Whitney Laboratory, St. Augustine, FL 32086.
authors.forename: K G
authors.initials: KG
authors.lastname: Krajniak
authors.forename: M J
authors.initials: MJ
authors.lastname: Greenberg
authors.forename: D A
authors.initials: DA
authors.lastname: Price
authors.forename: K E
authors.initials: KE
authors.lastname: Doble
authors.forename: T D
authors.initials: TD
authors.lastname: Lee
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004064:Digestive System / Q000187:drug effects; D019835:FMRFamide; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008974:Mollusca / Q000032:analysis* / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D009479:Neuropeptides / Q000032:analysis* / Q000494:pharmacology; D010413:Penis / Q000187:drug effects; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D011863:Radioimmunoassay
chemical_list: D009479:Neuropeptides; D019835:FMRFamide; C041307:small cardioactive peptide B; C054497:pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalaninamide; D011761:Pyrrolidonecarboxylic Acid