Binding of a monoclonal anti-DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis.
A monoclonal anti-DNA antibody PME77, spontaneously produced in autoimmune B/W mice, has been found to recognize identical protein(s) present at the surface of several human cell types involved in the pathogenesis of systemic lupus erythematosus: glomeruli, platelets, erythrocytes, T and B cells, and neuronal tissue. Data indicate that protein(s) could represent a major stimulus or the target of anti-DNA autoimmunity and could account for tissue lesions observed in this disease.
Jacob
L
L
Lety
M A
MA
Louvard
D
D
Bach
J F
JF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface; D001323:Autoantibodies / Q000378:metabolism*; D001402:B-Lymphocytes / Q000166:cytology; D002051:Burkitt Lymphoma / Q000473:pathology; D002460:Cell Line; D004247:DNA / Q000276:immunology*; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007122:Immunoelectrophoresis; D007678:Kidney Glomerulus / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001323:Autoantibodies; D000939:Epitopes; D008565:Membrane Proteins; D004247:DNA