title: Number of glucocorticoid receptors in lymphocytes and their sensitivity to hormone action.
abstract: The study demonstrated a decreased level of glucocorticoid receptors (GR) in peripheral blood lymphocytes from hypercholesterolemic subjects, and an elevated level in patients with acute myocardial infarction. In the lymphocytes with a high GR number, dexamethasone inhibited [3H]-thymidine and [3H]-acetate incorporation into DNA and cholesterol, respectively, in the same manner as in the control cells. On the other hand, a decreased GR number resulted in a less efficient dexamethasone inhibition of the incorporation of labeled compounds. These data showed that the sensitivity of lymphocytes to glucocorticoids changed only with a decrease of GR level.
authors.affiliation: USSR Research Centre for Preventive Medicine, Moscow.
authors.forename: I E
authors.initials: IE
authors.lastname: Petrichenko
authors.lastname: Shakhov YuA
authors.forename: N A
authors.initials: NA
authors.lastname: Gratsianski
authors.forename: O I
authors.initials: OI
authors.lastname: Aleshin
authors.forename: N V
authors.initials: NV
authors.lastname: Chepurnenko
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D003907:Dexamethasone / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D004247:DNA; D002784:Cholesterol