title: Lipid metabolism during the initiation of lactation in the rat. The effects of starvation and tumour growth.
abstract: 1. The effects of starvation post partum (24 h) and tumour growth pre partum on the initiation of lactation in the rat were studied. 2. Tumour growth decreased food intake at 24 h, but not at 2 days post partum. 3. Pup growth rate increased with hyperphagia; starvation and tumour burden decreased pup growth, and starvation decreased maternal body weight. 4. Starvation decreased gastrointestinal-tract mass; tumour growth decreased gastrointestinal-tract and mammary-gland mass. 5. Mammary-gland DNA-synthesis rate was high immediately post partum, but decreased by day 3 of lactation; starvation and tumour burden decreased this rate, and also decreased gastrointestinal-tract DNA-synthesis rate. 6. Arteriovenous differences for glucose and lactate across the mammary gland did not change with time, nor were they affected by the tumour. Starvation decreased arterial glucose and lactate, and the gland extracted less glucose but produced lactate. 7. Mammary-gland lipogenesis was sensitive to starvation and to tumour growth. 8. In contrast with the gradual development of mammary-gland lipogenic enzyme activities, lipoprotein lipase activity was high in the gland by 2 days post partum; starvation or tumour burden decreased the activity. 9. The mammary gland is sensitive post partum to decreased food intake, and to tumour presence. The effects of the latter are apparently independent of hypophagia.
authors.affiliation: Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
authors.forename: R D
authors.initials: RD
authors.lastname: Evans
authors.forename: D H
authors.initials: DH
authors.lastname: Williamson
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D004064:Digestive System / Q000378:metabolism; D004435:Eating; D005260:Female; D007773:Lactates / Q000097:blood; D007774:Lactation / Q000378:metabolism*; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007773:Lactates; D004247:DNA; D008071:Lipoprotein Lipase