[Changes in 5-HT2 receptor density induced by repeated treatment with 5-HT uptake inhibitor or 5-HT agonist].
It has been known that many antidepressant drugs which have serotonin (5-HT) antagonistic activities and 5-HT antagonists can induce the reduction of 5-HT2 receptor binding by their acute or successive administration. We investigated the effects of repeated treatment with 5-HT agonists on 5-HT2 receptors in rat cerebral cortex. We used citalopram as selective 5-HT uptake inhibitor, 5-hydroxytryptophan as 5-HT precursor, and 5-methoxy-N,N'-dimethyltryptamine as 5-HT2 agonist. The 5-HT2 receptor density was decreased by repeated treatment with these respective drugs. So it may be supposed that the reduction of 5-HT2 receptor binding is induced not only by 5-HT antagonists but also by 5-HT agonists.
Kubota
M
M
Laboratory of Biochemical Pharmacology & Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Ueno
K
K
Yamano
M
M
Kitagawa
H
H
D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D015283:Citalopram / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008732:Methoxydimethyltryptamines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D014363:Tryptamines / Q000494:pharmacology*
D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D014363:Tryptamines; D015283:Citalopram; D006916:5-Hydroxytryptophan