title: Computer model of ventricular interaction during left ventricular circulatory support.
abstract: The authors used a computer model of the heart and circulation to test the hypothesis that anatomic ventricular interactions are responsible for the observed instances of right ventricular failure during use of a left ventricular assist device. The model predicts that left ventricular pressure-unloading with a LVAD, in the presence of isolated systolic interaction, results in impairment of RV function, whereas with isolated diastolic interaction, RV function is improved. Due to competition between these two interactions, there is a negligible overall effect of ventricular anatomic interactions in determining right ventricular function in the normal heart.
authors.affiliation: Department of Cardiovascular Surgery, Pacific Presbyterian Medical Center, San Francisco, California.
authors.forename: J C
authors.initials: JC
authors.lastname: Woodard
authors.forename: D J
authors.initials: DJ
authors.lastname: Farrar
authors.forename: E
authors.initials: E
authors.lastname: Chow
authors.forename: W P
authors.initials: WP
authors.lastname: Santamore
authors.forename: D
authors.initials: D
authors.lastname: Burkhoff
authors.forename: J D
authors.initials: JD
authors.lastname: Hill
mesh_terms: D003198:Computer Simulation; D003971:Diastole / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology