title: Cerebral perfusion inhomogeneities in schizophrenia demonstrated with single photon emission computed tomography and Tc99m-hexamethylpropyleneamineoxim.
abstract: Cerebral blood flow was measured in relative terms with Tc99m-hexamethylpropyleneamineoxim (HMPAO) and single photon emission computed tomography (SPECT) in 28 female schizophrenic patients (20 acute and 8 chronic) classified according to DSM-III. Eleven normals served as controls. The acute patients were classified according to positive and negative symptoms. Patients with predominantly positive symptoms showed by and large normal and homogeneous cerebral isotope uptake. Those with negative symptoms, and the chronic patients, showed inhomogeneous tracer uptake with multiple regions of hypoperfusion in slices 4-6 cm above the orbitomeatal line. The findings support in principle the notion that schizophrenia with negative or chronic symptoms does not affect the whole brain homogeneously. Brain imaging with Tc99m-HMPAO and SPECT might be used to distinguish various types of schizophrenia.
authors.affiliation: Department of Nuclear Medicine, University Hospital Rebro, Zagreb, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Bajc
authors.forename: V
authors.initials: V
authors.lastname: Medved
authors.forename: M
authors.initials: M
authors.lastname: Basic
authors.forename: N
authors.initials: N
authors.lastname: Topuzovic
authors.forename: D
authors.initials: D
authors.lastname: Babic
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011569:Psychiatric Status Rating Scales; D012039:Regional Blood Flow; D012559:Schizophrenia / Q000000981:diagnostic imaging*; D012565:Schizophrenic Psychology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime