Immunoreactive 7B2 concentrations in rats with various endocrine conditions.
Changes in 7B2 immunoreactivity in the pituitary as well as in the other brain regions and gut after various endocrine situations were investigated. Gonadectomy and neonatal monosodium glutamate (MSG) treatment resulted in an appreciable increase in the pituitary 7B2 concentration, though 7B2 content in the MSG treated pituitary was not significantly different when calculation was performed on a per pituitary gland basis. The 7B2 concentration in the cerebellum, midbrain and cortex in thyroxine treated rats showed a significant increase, which might indicate possible thyroid hormone involvement in 7B2 metabolism in the brain. The pituitary 7B2 concentration during the estrous cycle did not change significantly. These results suggest that pituitary 7B2 may correlate to the pituitary gonadotropins and that brain 7B2 content may be modulated by thyroid hormones.
Suzuki
H
H
Department of Endocrinology, School of Medicine, Dokkyo University, Tochigi, Japan.
Hashigami
Y
Y
Suzuki
Y
Y
Kobori
H
H
Ohtake
R
R
Muramatsu
H
H
Tsuchiya
T
T
Ieiri
T
T
Shimoda
S
S
D000315:Adrenalectomy; D000818:Animals; D001923:Brain Chemistry; D002369:Castration; D004064:Digestive System / Q000032:analysis*; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D010907:Pituitary Hormones / Q000276:immunology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology; D013972:Thyrotropin / Q000097:blood
D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D010907:Pituitary Hormones; C497680:Scg5 protein, rat; D013972:Thyrotropin; D012970:Sodium Glutamate