[Biosynthesis of nucleic acids and proteins in different time periods of development in experimental myocarditis].
Biosynthesis of DNA, RNA and protein was studied in rat myocardium within 1, 3, 5, 7, 14, 21 and 28 days after administration of adrenaline toxic doses (300 mg/100 g of body mass). Synthesis of DNA was activated within 1-7 days, of total proteins--within 1-14 days, of RNA--within 1-"1 days, of action and myosin in myocardium--within 3-21 days. All the patterns studied were normalized within the subsequent periods (21-28 days) although they exceeded the control values. These data and morphological assays suggest that restoration processes were activated due to regeneration of the impaired cardiomyocytes or to proliferation of fibroblasts.
Paskevich
I F
IF
Denisov
V M
VM
Rukavishnikova
S M
SM
Pakhomov
V I
VI
Kalimanov
V G
VG
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004837:Epinephrine / Q000633:toxicity; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
D012313:RNA; D004247:DNA; D004837:Epinephrine
Issledovanie biosinteza nukleinovykh kislot i belkov v razlichnye sroki razvitiia éksperimental'nogo miokardita.