Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock.
Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.
Barclay
G R
GR
S.E. Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
Scott
B B
BB
Wright
I H
IH
Rogers
P N
PN
Smith
D G
DG
Poxton
I R
IR
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000032:analysis*; D004731:Endotoxins / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology* / Q000502:physiology; D008070:Lipopolysaccharides / Q000097:blood / Q000276:immunology*; D008297:Male; D011008:Pneumococcal Infections / Q000097:blood / Q000276:immunology / Q000628:therapy; D012772:Shock, Septic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004731:Endotoxins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C042058:core endotoxin