The use of a biological adhesive to achieve sutureless epikeratophakia.
An adhesive made of concentrated human fibrinogen produced from samples of single donor blood by a simple cryoprecipitation method was tested for its ability to bond lamellar corneal buttons in vitro and found to have a bond strength of 140 gm/cm2. The adhesive was successfully used to attach experimental epikeratophakia grafts in a rabbit model. The results were similar to those reported from an earlier trial using a commercially available adhesive prepared from pooled multi-donor human plasma. This experimental trial of single-donor adhesive demonstrates the possibility of successful use of autologous fibrinogen adhesive in human epikeratophakia. Autologous adhesive would remove the possible threat of transmitted disease posed by multi-donor adhesive and avoid immune reactions to foreign proteins.
Brittain
G P
GP
Department of Ophthalmology, Leicester Royal Infirmary.
Rostron
C K
CK
Morton
D B
DB
Rees
J E
JE
D000818:Animals; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation / Q000379:methods*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D014014:Tissue Adhesives
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives