[Subrenal capsule assay applied to prediction of tumor radiosensitivity].
The radiation responses of murine fibrosarcomas with different radiosensitivities (MCA-induced fibrosarcoma and NFSa), human tumors transplanted into athymic nude mice (HeLa, HMV-I and SNG-II) and fresh surgical sample of human tumor (seminoma) were investigated using the subrenal capsule assay with immuno-competent C3H/He, C57BL and ICR mice as host. Mice were immuno-suppressed by the combination of cyclophosphamide and cyclosporin A. Tumor growth-speed of each transplant under the renal capsule of mice was much greater than that of the subcutaneous counterparts. Tumor responses under the renal capsule to radiation were well correlated with the known radiosensitivities of the tumors. Above findings indicate that the subrenal capsule assay is a feasible method to predict the radiation response of a tumor.
Sato
S
S
Dept. of Radiology, Toho Univ. Oohashi Hospital.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D004407:Dysgerminoma / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007165:Immunosuppression Therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011237:Predictive Value of Tests; D011836:Radiation Tolerance; D013370:Subrenal Capsule Assay
D003524:Cyclosporins; D003520:Cyclophosphamide