title: Inhibition of IgE-mediated mast cell degranulation by sulphasalazine.
abstract: The effect of sulphasalazine on two mast cell populations and human peripheral leukocytes is reported. Sulphasalazine inhibited histamine release from mouse and rat mast cells, but it caused a potentiation of secretion in human peripheral leukocytes. The drug alone did not induce histamine release when administered without an anaphylactic stimulus. The results are discussed in terms of a possible mode of action of sulphasalazine in the treatment of inflammatory bowel disease.
authors.forename: K E
authors.initials: KE
authors.lastname: Barrett
authors.forename: T L
authors.initials: TL
authors.lastname: Tashof
authors.forename: D D
authors.initials: DD
authors.lastname: Metcalfe
mesh_terms: D000818:Animals; D003109:Colonic Diseases, Functional / Q000188:drug therapy; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology*; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D012460:Sulfasalazine / Q000494:pharmacology*
chemical_list: D007073:Immunoglobulin E; D012460:Sulfasalazine