title: Focal spinal muscular atrophy in two German shepherd pups.
abstract: Focal spinal muscular atrophy evolved rapidly in two German Shepherd pups 2 weeks after birth. By 1 month, the male and female littermates had developed a valgus deformity of the right forelimb, a flexed carpus, and arm and forearm muscle weakness and atrophy. In the male, less severe left forelimb weakness and wasting also occurred, and bilateral forelimb denervation potentials were recorded. Postmortem study of the male revealed asymmetric loss and degeneration of motoneurons in the cervical spinal cord intumescence. Degenerating neurons appeared vacuolated or chromatolytic. Chromatolysis was often peripheral and resulted from dispersion and loss of the free and attached ribosomes which normally from Nissl bodies. Although this focal neuronopathy was unlike motoneuron diseases described previously in animals, it resembled the asymmetric and unilateral, benign spinal muscular atrophies found in humans.
authors.affiliation: Department of Anatomy, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: J F
authors.initials: JF
authors.lastname: Cummings
authors.forename: C
authors.initials: C
authors.lastname: George
authors.forename: A
authors.initials: A
authors.lastname: de Lahunta
authors.forename: B A
authors.initials: BA
authors.lastname: Valentine
authors.forename: P F
authors.initials: PF
authors.lastname: Bookbinder
mesh_terms: D000818:Animals; D001284:Atrophy; D004285:Dogs; D008297:Male; D009046:Motor Neurons / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*