[Preparation of preoral sustained-release preparations with a base of biodegradable polymers. 3. Preparation of matrix tablets with a base of poly-3-hydroxybutyric acid].
Poly-3-hydroxybutyric acid belongs to the biological polymers, which are produced by bacterials. The determination of the grain size, moisture content, flowability and the parameters for the direct compression was performed in regard of their use as auxillary substance for the preparation of solid sustained release dosage forms. The production of the matrix tablets was performed on the basis of a factorial design. The content of substance, an addition of Heweten 12 and the compression power served as factors. Caffeine was used as model drug. The in vitro release values show, that all three factors have an influence of the drug release. Optimized matrix tablets were produced on the basis of this result.
Mank
R
R
Sektion Chemie-Bereich Pharmazie, Humboldt-Universität zu Berlin.
Kala
H
H
Richter
M
M
Babel
W
W
Sattler
K
K
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D006885:Hydroxybutyrates / Q000032:analysis; D011091:Polyesters / Q000032:analysis; D011312:Pressure; D012995:Solubility; D000094122:Polyhydroxybutyrates
D003692:Delayed-Action Preparations; D005079:Excipients; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates
Darstellung peroraler Retardarzneiformen auf der Basis von biologisch abbaubaren Polymeren. 3. Mitteilung4: Darstellung von Matrixtabletten auf der Basis von Poly-3-hydroxybuttersäure.