title: Subacute sclerosing panencephalitis. Current status.
abstract: Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disease of childhood that is due to a persistent measles infection. Owing to a nationwide immunization program in the United States, the incidence has decreased considerable, coexistent with the decline in natural measles infection. The disease, now fully understood, still represents a great international problem. Clinical presentation, etiology, pathogenesis, prevention, and treatment are updated in this article.
authors.forename: P R
authors.initials: PR
authors.lastname: Dyken
mesh_terms: D000293:Adolescent; D000547:Amantadine / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000627:therapeutic use; D008297:Male; D008459:Measles virus / Q000276:immunology; D010166:Palliative Care; D012042:Registries; D012424:Rural Population; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins; D000547:Amantadine; D007542:Inosine Pranobex