title: Preparation of chiral, highly functionalized cyclopentanes and its application to the synthesis of prostaglandin E1.
abstract: This paper describes the preparation of the polyfunctionalized cyclopentane ((+/-)-5) by silica gel-catalyzed air-oxidation, and its kinetic resolution by means of microbial reduction with Rhodotorula rubra to afford optically pure (-)-5 (greater than 99% ee). Starting with (-)-5, a new route to prostaglandin E1 was established.
authors.forename: K
authors.initials: K
authors.lastname: Okano
authors.forename: H
authors.initials: H
authors.lastname: Suemune
authors.forename: K
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000527:Alprostadil / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis*
chemical_list: D003517:Cyclopentanes; D000527:Alprostadil