title: Spontaneous noncardiac chest pain: value of ambulatory esophageal pH and motility monitoring.
abstract: We performed esophageal investigations in 20 patients suffering from noncardiac chest pain in order to assess the diagnostic value of short- versus long-term manometric and pH studies. Patients had baseline esophageal manometry with two provocative tests: a Bernstein test and an intravenous injection of edrophonium. On a separate occasion they had a 24-hr ambulatory esophageal pH and motility recording. The Bernstein test provoked chest pain in two patients, while edrophonium injection did not elicit pain in any of the patients. The ambulatory pH study helped to establish the esophagus as the likely source of pain in one patient, and the ambulatory motility one in another. In our experience, ambulatory pH and motility recordings have a low diagnostic yield in the evaluation of patients with noncardiac chest pain.
authors.affiliation: GI Science Research Unit, London Hospital Medical College, United Kingdom.
authors.forename: E E
authors.initials: EE
authors.lastname: Soffer
authors.forename: P
authors.initials: P
authors.lastname: Scalabrini
authors.forename: D L
authors.initials: DL
authors.lastname: Wingate
mesh_terms: D000328:Adult; D000368:Aged; D002637:Chest Pain / Q000209:etiology*; D004491:Edrophonium / Q000009:adverse effects; D004935:Esophageal Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D012008:Recurrence
chemical_list: D004491:Edrophonium