title: Treatment of lymphangioleiomyomatosis. A meta-analysis.
abstract: Lymphangioleiomyomatosis is a rare disease which afflicts young women of childbearing age. It is sufficiently uncommon that randomization or any other systematic evaluation of regimens of treatment has been difficult. Review of scattered case reports implies that a number of hormonal manipulations may be equally effective. A comprehensive review of the literature revealed 30 cases of LAM treated with eight regimens of treatment. Evaluation with predetermined criteria (meta-analysis) shows that administration of progesterone or oophorectomy or both are the most effective treatments, resulting in improvement or stabilization of the disease in the majority of cases.
authors.affiliation: Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5000.
authors.forename: A H
authors.initials: AH
authors.lastname: Eliasson
authors.forename: Y Y
authors.initials: YY
authors.lastname: Phillips
authors.forename: M F
authors.initials: MF
authors.lastname: Tenholder
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery / Q000628:therapy*; D008203:Lymphangiomyoma / Q000601:surgery / Q000628:therapy*; D008232:Lymphoproliferative Disorders / Q000628:therapy*; D015201:Meta-Analysis as Topic; D010052:Ovariectomy; D011374:Progesterone / Q000627:therapeutic use
chemical_list: D011374:Progesterone