title: Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Menière's disease.
abstract: Severe unilateral cases of Menière's disease can be successfully treated with ototoxic antibiotics. Among them gentamicin sulfate gives the safest results. With the aid of a small syringe this antibiotic is introduced into the external auditory canal 5 times/day. From there it reaches the middle ear through a ventilating tube by using a Politzer bag. Gentamicin then penetrates the round and oval windows, where it influences inner ear function. Of 92 patients treated during the past 20 years, more than 90% have had no further attacks after therapy.
authors.affiliation: Städtische HNO-Klinik, Wuppertal, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Lange
mesh_terms: D001309:Auditory Threshold / Q000187:drug effects; D004334:Drug Administration Schedule; D004432:Ear, Middle / Q000187:drug effects; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D008575:Meniere Disease / Q000188:drug therapy*; D008876:Middle Ear Ventilation; D004856:Postural Balance / Q000187:drug effects
chemical_list: D005839:Gentamicins