The determination of fenspiride in human plasma and urine by liquid chromatography with electrochemical or ultraviolet detection.
A selective and sensitive method for the determination of fenspiride in biological fluids is described. The method involves liquid-liquid extraction followed by separation on a reversed-phase column with electrochemical detection for low levels of the drug in plasma (less than or equal to 100 ng ml-1) or UV absorption for higher concentrations in plasma or urine. The method is suitable for pharmacokinetic analyses and drug monitoring studies.
Sauveur
C
C
Bio-Pharmacie Servier, Orléans, France.
Baune
A
A
Vergnes
N
N
Jeanniot
J P
JP
D002853:Chromatography, Liquid; D004563:Electrochemistry; D006801:Humans; D007202:Indicators and Reagents; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds / Q000032:analysis* / Q000097:blood / Q000652:urine
D007202:Indicators and Reagents; D013141:Spiro Compounds