Immune response to ultraviolet-induced tumors. I. Transplantation immunity developing in syngeneic mice in response to progressor ultraviolet-induced tumors.
Ultraviolet-light-induced murine skin tumors were analyzed for the ability to induce transplantation immunity and cytotoxic lymphocytes in syngeneic mice. A correlation was found between tumor regression and the induction of cytotoxic T cells with specificity for a unique tumor-associated antigen. Processing tumors possessed tumor-associated transplantation antigens (TATA), which could be demonstrated by transplantation in hyperimmunized mice. Progression correlated with a lack of splenic cytotoxic T cell reactivity. High levels of in situ cytotoxic reactivity could be induced by presenting the tumor-specific antigen on nongrowing tumor cells. Tumor-bearer hosts were shown to be sensitized to TATA because cultured tumor-bearer T cells adoptively transferred protection against tumor outgrowth. Mechanisms of the in vivo suppression of antitumor immunity are discussed.
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D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001202:Ascitic Fluid / Q000276:immunology / Q000473:pathology; D002460:Cell Line; D000939:Epitopes; D005354:Fibrosarcoma / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007116:Immunization, Passive; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D009365:Neoplasm Regression, Spontaneous; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000473:pathology; D014181:Transplantation Immunology / Q000528:radiation effects; D014466:Ultraviolet Rays
D000951:Antigens, Neoplasm; D000939:Epitopes