[Experimental gerontology and the reliability theory].
The reliability theory was elaborated for the estimation of the reliable action of technical systems. When it is applied to biological systems, it is important to characterize unequivocally the disorder which will substantially after the reliable activity of the entire organism or of individual systems. The authors investigated in their experiments during the postnatal development of rats changes in the erythrocyte stability. The age-conditioned decline was evaluated as a disorder. The erythrocyte stability was assessed in animals of different age, i. e. in 4-, 6-, 10-, 18- and 24-month-old animals by the method of the haemolytical action of brilliant cresyl blue in isotonic NaCl solution. The results of experiments suggest that when red cells were incubated in isotonic NaCl solution only, there was no difference in the lysis of erythrocytes in different age groups. However, when they were incubated in isotonic NaCl with brilliant cresyl blue, there was a significantly greater haemolysis in red cells of 4-, 18- and 24-month-old rats, as compared with the lysis of red cells from 6- and 10-month-old animals. Red cell lysis conditioned by brilliant cresyl blue in relation to age is discussed from the aspect of the reliability theory.
Nicák
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Molnár
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D000375:Aging / Q000097:blood*; D000818:Animals; D006461:Hemolysis / Q000187:drug effects; D007552:Isotonic Solutions; D008297:Male; D010078:Oxazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D007552:Isotonic Solutions; D010078:Oxazines; D012965:Sodium Chloride; C006797:Brilliant Cresyl Blue
Experimentálna gerontológia a teória spol'ahlivosti.