Alpha-fetoprotein favours accumulation of estrone but not arachidonic acid into the fetal and new-born rat brain.
Tritriated estrone or arachidonic acid, two high affinity ligands for rat alpha-fetoprotein (AFP), were injected into adult, pregnant or newborn Sprague Dawley rats in order to evaluate their possible transfer into the brain. This study shows that the developing brain accumulates the estrogen but not the fatty acid, suggesting that the uptake of AFP by the developing brain is a mechanism for transporting estrogens, but not fatty acids.
Aussel
C
C
Laliberté
F
F
Masseyeff
R
R
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D004970:Estrone / Q000378:metabolism*; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000378:metabolism*
D001095:Arachidonic Acids; D000509:alpha-Fetoproteins; D016718:Arachidonic Acid; D004970:Estrone