title: Lack of effect of ponsinomycin on the plasma pharmacokinetics of theophylline.
abstract: The influence of ponsinomycin on the pharmacokinetics of theophylline has been studied in 12 young healthy volunteers. They received 10 doses of theophylline 200 mg every 8 h p.o., successively in the absence and then in the presence of ponsinomycin. This new macrolide, structurally related to midecamycin, was given in the therapeutic dose of 800 mg b.d. for 5 days, starting 2 days before the second phase of treatment with theophylline. The pharmacokinetic parameters of theophylline, calculated from its plasma concentration at steady-state, were not affected by the co-treatment. In particular, there was no significant difference between the peak and trough plasma levels, apparent clearance or apparent elimination half-life of theophylline in the absence and the presence of ponsinomycin. Only renal clearance was slightly (27%) but significantly increased by the co-treatment. The results suggest that ponsinomycin would be a good choice if a macrolide antibiotic were needed in patients being treated with theophylline.
authors.affiliation: ADPC, Pharmacokinetic Department, Poitiers, France.
authors.forename: W
authors.initials: W
authors.lastname: Couet
authors.forename: I
authors.initials: I
authors.lastname: Ingrand
authors.forename: B
authors.initials: B
authors.lastname: Reigner
authors.forename: J
authors.initials: J
authors.lastname: Girault
authors.forename: J
authors.initials: J
authors.lastname: Bizouard
authors.forename: J B
authors.initials: JB
authors.lastname: Fourtillan
mesh_terms: D000328:Adult; D004347:Drug Interactions; D006801:Humans; D008297:Male; D015644:Miocamycin / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D015644:Miocamycin; D013806:Theophylline