[Study of the mode of operation of the equipment for membrane extraction of substances from the blood in emulsions].
The authors suggest an apparatus make-up for cholesterol extraction in multiple emulsion from blood. It is intended for homeostasis correction according to the hemoperfusion scheme with the use of this apparatus instead of the hemoperfusion one. The influence of the velocity of the blood flow, the rate of stirring and emulsion volume on the modes of operation of the apparatus was investigated. The most efficient mode of operation was chosen, according to which the entry of the extracting agent into the body was completely excluded whereas emulsion saturation with cholesterol was reached after 1.5 h. A series of animal experiments were carried out using the same apparatus but 10 times smaller, with the emulsion containing ethanol and diethyl ether in the internal phase. The mean degree of cholesterol extraction amounted to 22.4%, while the main biochemical components of blood remained unchanged.
Iurtov
E V
EV
Koroleva
M Iu
MIu
Sergienko
V I
VI
Lopukhin
Iu M
IuM
D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood*; D004655:Emulsions; D004867:Equipment Design; D000431:Ethanol / Q000494:pharmacology; D004986:Ether / Q000494:pharmacology; D006464:Hemoperfusion / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008567:Membranes, Artificial; D014115:Toxemia / Q000097:blood*; D014118:Toxins, Biological / Q000097:blood* / Q000302:isolation & purification; D014586:USSR
D004655:Emulsions; D008567:Membranes, Artificial; D014118:Toxins, Biological; D004986:Ether; D000431:Ethanol; D002784:Cholesterol
Issledovanie rezhimov raboty apparata dlia membrannoĭ ékstraktsii vo mnozhestvennoĭ ému'lsii iz krovi.