Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons.
Suicide transport of the toxic lectin, ricin, by hypoglossal and vagus neurons resulted in motor neuron loss in the associated nuclei, and reduced the binding of the 125I-Bolton-Hunter labeled substance P in the same nuclei. These data show that substance P receptors are located on the cell bodies of medullary somatic and preganglionic motor neurons of the hypoglossal and vagus nerves, and that suicide transport is a useful technique to determine the cellular localization of binding sites within a nucleus.
Helke
C J
CJ
Charlton
C G
CG
Wiley
R G
RG
D000818:Animals; D001370:Axonal Transport; D002470:Cell Survival; D007002:Hypoglossal Nerve / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012276:Ricin / Q000378:metabolism* / Q000494:pharmacology; D013373:Substance P / Q000378:metabolism; D014630:Vagus Nerve / Q000378:metabolism*
D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P; D012276:Ricin