FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. II. Structure of FK409 and its precursor FR-900411.
In a purification study of novel vasodilator FK409 from the fermentation broth of Streptomyces griseosporeus, we found the existence of FR-900411, a precursor of FK409 in the broth, suggesting that FK409 was derived from FR-900411 via a chemical reaction. We therefore isolated FR-900411 from the broth. The structure of FK409 and FR-900411 were determined to be 1 and 2 respectively, on the basis of spectroscopic and chemical evidence.
Hino
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Ando
T
T
Takase
S
S
Itoh
Y
Y
Okamoto
M
M
Kohsaka
M
M
Aoki
H
H
Imanaka
H
H
D000466:Alkadienes / Q000302:isolation & purification; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009574:Nitro Compounds; D011355:Prodrugs; D051381:Rats; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis*; D014665:Vasodilator Agents
D000466:Alkadienes; D009574:Nitro Compounds; D011355:Prodrugs; D014665:Vasodilator Agents; C061873:FR 900411; C061872:FK 409