title: Syntheses of 24R,25-dihydroxy-[6,19,19-3H]vitamin D3 and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3.
abstract: 24R,25-Dihydroxy-[6,19,19-3H]vitamin D3 with a specific activity of 54 Ci/mmol and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3 with 2.6 deuterium atoms/mol were synthesized in four steps starting from 24R,25-Dihydroxyvitamin D3 via its sulfur dioxide adduct.
authors.affiliation: Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Niimura
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000138:chemical synthesis*; D003903:Deuterium; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry; D013458:Sulfur Dioxide; D014316:Tritium
chemical_list: D013458:Sulfur Dioxide; D014316:Tritium; D015650:24,25-Dihydroxyvitamin D 3; D003903:Deuterium