[The inhibition of succinate, beta-oxybutyrate and glutamate transport in the liver mitochondria of hibernating susliks].
Studies have been made on the permeability of the inner membrane of the liver mitochondria from hibernating and active ground squirrels for succinate, glutamate, hydroxybutyrate and inorganic phosphate. The permeability was calculated from the rate of mitochondrial swelling in 100 mM ammonium salts of the substrates and phosphate. It was shown that the rate of mitochondrial swelling in hibernating animals is 2--3 times lower than in active ones, being essentially identical in a solution of ammonium phosphate. It was concluded that the permeability of the inner mitochondrial membrane for the substrates decreases in hibernating animals, remaining unaffected for phosphate. Calcium-induced activation of membrane phospholipase A2 facilitates the transport of oxidative substrates into the mitochondria of hibernating ground squirrels, significant increase in the mitochondrial respiration being simultaneously observed. The data obtained suggest that inhibition of transport of oxidative substrates is one of the main factors which account for a low respiration rate in the mitochondria of hibernating animals.
Brustovetskiĭ
N N
NN
Amerkhanov
Z G
ZG
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006605:Hibernation / Q000502:physiology*; D006885:Hydroxybutyrates / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D012589:Sciuridae / Q000378:metabolism*; D013386:Succinates / Q000378:metabolism*; D019802:Succinic Acid
D005971:Glutamates; D006885:Hydroxybutyrates; D010710:Phosphates; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid; D020155:3-Hydroxybutyric Acid
Ingibirovanie transporta suktsinata, beta-oksibutirata i glutamata v mitokhondrii pecheni giberniruiushchikh suslikov.