Role of free radicals and lipid peroxidation in gastric mucosal injury induced by ischemia-reperfusion in rats.
Ischemia and reperfusion are of the greatest importance in the pathology of many diseases. We investigated the roles of oxygen-derived free radicals and lipid peroxidation in gastric mucosal injury, such as spotty and linear hemorrhagic erosions, induced in rats by ischemia-reperfusion. The gastric mucosal injury and the increase in thiobarbituric acid (TBA) reactants in the gastric mucosa induced by ischemia-reperfusion were significantly inhibited by treatment with SOD and catalase. These results suggest that oxygen-derived free radicals and lipid peroxidation play important roles in the pathogenesis of acute gastric mucosal lesions induced by ischemia-reperfusion.
Ueda
S
S
First Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yoshikawa
T
T
Takahashi
S
S
Ichikawa
H
H
Yasuda
M
M
Oyamada
H
H
Tanigawa
T
T
Sugino
S
S
Kondo
M
M
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D005609:Free Radicals; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008054:Lipid Peroxides / Q000502:physiology*; D008297:Male; D010100:Oxygen / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000473:pathology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D013858:Thiobarbiturates / Q000494:pharmacology
D005609:Free Radicals; D008054:Lipid Peroxides; D013858:Thiobarbiturates; D002374:Catalase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid; D010100:Oxygen