Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action.
Flavone acetic acid (FAA, LM 975) causes regression and growth retardation in several solid murine tumours. The mechanism of action is unknown, although various lines of evidence suggest an indirect cytotoxic effect. We have carried out preliminary studies on the effect of FAA on relative blood flow in six experimental murine tumours using 86RbCl extraction. We have also measured growth delay after treatment with the same dose of FAA (200 mg/kg). The data show that the drug induces a drop in tumour perfusion within 6 h of treatment in all of the tumours, and that this can be correlated with the growth delay measured. We conclude that vascular collapse may be an important component of the action of this drug, and that further investigation of this phenomenon is warranted.
Hill
S
S
Gray Laboratory of the Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Williams
K B
KB
Denekamp
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy; D012039:Regional Blood Flow / Q000187:drug effects
D000970:Antineoplastic Agents; D005419:Flavonoids; C049328:flavone acetic acid