title: [Peroxide lipid and evoked spinal potentials in experimental spinal cord ischemia].
abstract: The author of this report has studied peroxide lipid and evoked potentials of the spinal cord during ischemia and after reperfusion. In addition, he has studied effects of vitamin E (V.E.) upon ischemic spinal cord. The ischemia of the spinal cord was experimentally produced by clamping the thoracic aorta of Wistar rats and subsequently removing the clamps. Wistar rats were given diet containing 2 IU/100 g (control group) or 50 IU/100 g (V.E. group) of alpha-tocopherol acetate for 6 weeks before experiments. In the V.E. group the quantity of thiobarbituric acid reactive substance (TBARS) in the spinal cord after clamp removal was lower than the control group. The V.E. content in the spinal cord indicated a negative correlation to the TBARS values. The evoked spinal potentials in both groups disappeared due to spinal cord ischemia. The control group displayed wave form loss earlier than the V.E. group. It is conceivable that lipid peroxidation correlate to the tissue damage following spinal cord ischemia and reperfusion, and V.E. has the preventive effect to the damage.
authors.affiliation: Department of Orthopedic Surgery, School of Medicine, Tokushima University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Teramae
mesh_terms: D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D007511:Ischemia / Q000503:physiopathology*; D008054:Lipid Peroxides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D013116:Spinal Cord / Q000098:blood supply* / Q000503:physiopathology; D013858:Thiobarbiturates; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D008054:Lipid Peroxides; D013858:Thiobarbiturates; D014810:Vitamin E; C029684:thiobarbituric acid