Immunoprotection of guinea pigs against experimental acute pyelonephritis after the administration of Escherichia coli purified fimbriae.
Experimental results of the present study evidenced the following aspects: a) the antigen, prepared from type I Escherichia coli purified fimbriae (H. 2946 strain), induced immunity at urinary tract level; b) the immunoprotection induced by oral vaccination with multiple doses of fimbriated antigen produced a significant decrease of acute pyelonephritis in newborn guinea pigs and at the same time, a local protection of the urinary tract; c) the immunoprophylaxis by vaccine prepared from fimbriae represents a preferential solution for urinary tract infections prevention in general and especially in children; d) the frequency distribution differences between "protected" and "non-protected" animals were evaluated by chi-square--test with YATES correction and proved to be statistically significant at probability levels.
Dima
V F
VF
Petrovici
A
A
Dima
S V
SV
Petrovici
M
M
Burghelea
B
B
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D010861:Fimbriae, Bacterial / Q000276:immunology* / Q000648:ultrastructure; D006168:Guinea Pigs; D007114:Immunization; D008854:Microscopy, Electron; D011704:Pyelonephritis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines