Blood coagulation changes in liver disease.
The study describes the results of prothrombin time (PT), Anti-thrombin III (AT III) and fibrin polymerization curve (FPC) measured simultaneously in patients with liver disease who were divided into two groups: cirrhotics (n = 37) and miscellaneous liver disease (n = 35). There was significant prolongation of PT in 82% of cirrhotics and in 17% of the miscellaneous liver disease group. In contrast significant reduction of AT III levels was noted in 94% of cirrhotics and 31% of the miscellaneous liver disease group. Abnormal FPC was seen in 88% and 32% respectively. There was a good correlation between PT and AT III levels. It was concluded that AT III measurement is a more sensitive indicator than PT and FPC in the assessment of hepatocellular dysfunction.
al Mofleh
I A
IA
Department of Medicine, College of Medicine, Riyadh, Kingdom of Saudi Arabia.
al Faleh
F Z
FZ
Allam
A
A
Gader
A M
AM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D012529:Saudi Arabia; D014914:Whole Blood Coagulation Time