title: Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?
abstract: Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions. The interaction of nonsteroidal antiinflammatory agents and beta-blockers and their role in the control of blood pressure in obstetrics are discussed. Indomethacin should not be given to pregnant patients with hypertension treated with beta-blockers.
authors.affiliation: Department of Obstetric and Gynecology, Beilins on Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Schoenfeld
authors.forename: S
authors.initials: S
authors.lastname: Freedman
authors.forename: M
authors.initials: M
authors.lastname: Hod
authors.forename: Y
authors.initials: Y
authors.lastname: Ovadia
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D010869:Pindolol / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D011433:Propranolol; D010869:Pindolol; D007213:Indomethacin