Serum interleukin 2 (IL-2) levels and prolactin bioactive/radioimmunoassay ratios of women at risk for breast cancer.
In a cohort of women at high risk for developing breast cancer we have observed that 74% of the women with prolactin BA/RIA ratios over 1.4 had detectable levels of IL-2 in their serum (990 +/- 400 mU/ml) and the IL-2 levels were correlated with the prolactin BA/RIA ratio (R = 0.79; P greater than 0.004). Women with BA/RIA ratios were either approximately 1.0 or less than 0.55 had lower levels of serum IL-2 (177 +/- 70 and 130 +/- 40 mU/ml, respectively). Detectable levels of serum IL-2 were found in 58% of those women with BA/RIA ratios of 1.0 and 55% of those with BA/RIA ratios less than 0.55.
Gala
R R
RR
Wayne State University School of Medicine, Department of Physiology, Detroit, MI 48201.
Martino
S
S
Wiejowski
S A
SA
Kresge
C L
CL
Alonso
M M
MM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001681:Biological Assay; D001943:Breast Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011863:Radioimmunoassay; D012307:Risk Factors
D007376:Interleukin-2; D011388:Prolactin