[Effect of chang chun dan on noradrenaline levels of the brain and plasma in aged rats].
In this paper, the rats were randomly divided into three groups: (1) Young (Y); (2) Aged (A); (3) Aged rats treated with Chang Chun Dan (AT) for 3 months. The level of noradrenaline (NA) in brain and plasma of three group rats had been examined by radioenzymatic assay. The changes of fluorescent intensity of NA in locus coeruleus had been observed by histochemical method. The levels of NA in hypothalamus of three groups were 162 +/- 9.93, 209 +/- 13.2, 167 +/- 11.8 ng/g wet tissues and in plasma were 1.29 +/- 0.16, 0.84 +/- 0.08, 0.96 +/- 0.08 ng/ml respectively. The results showed that the NA level of hypothalamus in AT group was lower than that of A group (P less than 0.05), and the NA level in Y group was raised markedly comparing with A group (P less than 0.01). The plasma NA level in A group was significantly lower than that in Y group (P less than 0.05). The NA level in AT group was raised a little comparing with A group. But the fluorescent intensity of NA in locus coeruleus between AT and A group was no difference. The results suggested that the changes of neurotransmitter induced by Chang Chun Dan may be basis of delaying aging effect and improving symptom of Kidney deficiency induced by aging.
Cheng
L Y
LY
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007668:Kidney / Q000502:physiology; D008297:Male; D008516:Medicine, Chinese Traditional; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D009638:Norepinephrine