title: Adenosine analogs elevate N-acetylserotonin and melatonin in rat pineal gland.
abstract: Adenosine, S-adenosyl-L-homocysteine, adenosine analogs such as 5'-N-ethylcarboxamidoadenosine and mioflazine, a nucleoside transport inhibitor, injected intraperitoneally at 09.00 h during the light period increased melatonin levels in the pineal gland of the rat. The largest increase occurred with 1 mg/kg 5'-N-ethylcarboxamidoadenosine. A representative time-response curve with 5'-N-ethylcarboxamidoadenosine (1 mg/kg) showed a maximal peak of N-acetylserotonin and melatonin 2 and 4 h after injection, respectively. These results are discussed in relation with the possible modulation through A2 receptors of melatonin synthesis in the pineal gland.
authors.affiliation: INSERM U .205, Chimie Biologique INSA, Villeurbanne, France.
authors.forename: A
authors.initials: A
authors.lastname: Gharib
authors.forename: D
authors.initials: D
authors.lastname: Reynaud
authors.forename: N
authors.initials: N
authors.lastname: Sarda
authors.forename: B
authors.initials: B
authors.lastname: Vivien-Roels
authors.forename: P
authors.initials: P
authors.lastname: Pévet
authors.forename: H
authors.initials: H
authors.lastname: Pacheco
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D012701:Serotonin; D019830:Adenosine-5'-(N-ethylcarboxamide); D008550:Melatonin; D000241:Adenosine; C006389:N-acetylserotonin