Comparative pharmacokinetic and pharmacodynamic study of four different brands of propranolol in normal volunteers.
The pharmacokinetic and pharmacodynamic studies of four different brands of propranolol (Inderal, Ciplar, Corbeta and Propal) were carried out after single and multiple dosing on six normal adult healthy volunteers in a randomized crossover fashion to determine any inter-brand variations in bioavailability and pharmacodynamic effects. No significant difference was observed in any of the pharmacokinetic and pharmacodynamic parameters of four different brands of propranolol studied.
Biswas
N R
NR
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Garg
S K
SK
Kumar
N
N
Mukherjee
S
S
Sharma
P L
PL
D000328:Adult; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D011433:Propranolol / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D011433:Propranolol