title: Intracranial pressure changes following primate subarachnoid haemorrhage.
abstract: In 29 anaesthetized baboons avulsion of a small intracranial artery was used to produce a subarachnoid haemorrhage, in a closed-skull situation. Intracranial pressure was measured by extradural transducers, and arterial pressure was also measured continuously, with periodic measurements of cerebral blood flow. After haemorrhage there was an immediate fall in cerebral perfusion pressure in nearly all cases, reaching zero in 9 animals. In 18 there was a significant pressor response in the systemic circulation, but perfusion pressure usually remained low in spite of this response. Perfusion pressure recovered after a few minutes in most cases. In the 19 cases where intracranial pressure was measured on both sides, differences occurred in 11, with the higher pressure always on the same side as the haemorrhage. The difference was evident very soon after haemorrhage in 9 cases, and lasted over half an hour in 5 of them. The mechanism of arrest of bleeding was, in most of this series, not that of a zero perfusion pressure. Explanations for this and for the occurrence of differential pressures are discussed.
authors.affiliation: Department of Neurological Surgery, Institute of Neurology, Queen Square, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Dorsch
authors.forename: N M
authors.initials: NM
authors.lastname: Branston
authors.forename: L
authors.initials: L
authors.lastname: Symon
authors.forename: J
authors.initials: J
authors.lastname: Jakubowski
mesh_terms: D000818:Animals; D007427:Intracranial Pressure; D010215:Papio; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*