title: Progression of hydrocephalus during corticosteroid therapy for neurosarcoidosis.
abstract: We describe a patient with sarcoid meningitis and hydrocephalus who improved rapidly after initiation of oral prednisone therapy, but who later decompensated acutely and required an emergency ventriculoperitoneal shunt. Hydrocephalus associated with neurosarcoidosis may progress despite steroid treatment, even when symptoms have improved. If hydrocephalus associated with neurosarcoidosis is treated with corticosteroids and without a shunt procedure we suggest that the corticosteroids should be continued at high doses for a prolonged period.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor.
authors.forename: K T
authors.initials: KT
authors.lastname: Foley
authors.forename: J D
authors.initials: JD
authors.lastname: Howell
authors.forename: L
authors.initials: L
authors.lastname: Junck
mesh_terms: D000328:Adult; D002557:Cerebrospinal Fluid Shunts; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy; D010529:Peritoneal Cavity; D011241:Prednisone / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D011241:Prednisone