Alpha 1-microglobulin: a new antigenic component of the epidermo-dermal junction in normal human skin.
Monoclonal antibodies to human alpha 1-microglobulin (alpha 1-m), a glycoprotein present in most biological fluids, reacted with the basement membrane of the epidermo-dermal junction and that of eccrine sweat glands in normal human skin. This immunofluorescence was specific in that control antibodies of known well-defined reactivity did not stain these structures. Therefore, alpha 1-m seems to be a new antigenic component of the junction and it may be an interesting antigen to study in diseases of this area.
Bouic
P
P
Kanitakis
J
J
Schmitt
D
D
Vincent
C
C
Revillard
J P
JP
Thivolet
J
J
D000510:Alpha-Globulins / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000941:Antigens / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology; D004439:Eccrine Glands / Q000276:immunology; D004817:Epidermis / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn; D012867:Skin / Q000276:immunology*
D000510:Alpha-Globulins; D000911:Antibodies, Monoclonal; D000941:Antigens; C016001:alpha-1-microglobulin