Glycyl-L-glutamine opposes the fall in choline acetyltransferase in the denervated superior cervical ganglion of the cat.
Intracarotid infusion of 3 microM glycyl-L-glutamine was found to oppose the fall in the choline acetyl-transferase content of the preganglionically denervated cat superior cervical ganglion; this same effect has been demonstrated previously for acetylcholinesterase content. Because choline acetyltransferase, in contrast to acetylcholinesterase, occurs exclusively in the preganglionic axons and their terminals, this finding raises the possibility that glycyl-L-glutamine opposes postsectional axonal degeneration.
Koelle
G B
GB
Department of Pharmacology, Medical School, University of Pennsylvania, Philadelphia 19104-6084.
O'Neill
J J
JJ
Thampi
N S
NS
Han
M S
MS
Caccese
R
R
D000818:Animals; D002339:Carotid Arteries; D002415:Cats; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003714:Denervation; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D007261:Infusions, Intra-Arterial; D012016:Reference Values
D004151:Dipeptides; C039788:glycylglutamine; D002795:Choline O-Acetyltransferase