L-tyrosine induces synthesis of melanogenesis related proteins.
In cultured amelanotic hamster melanoma cells L-tyrosine induces melanogenesis. This induction involves an increase in intracellular concentration of proteins precipitated by polyclonal anti-tyrosinase antibodies, and stimulation of the Vmax of tyrosinase activity. Therefore it is suggested that in hamster melanoma cells L-tyrosine induces synthesis of tyrosinase and melanogenesis related proteins.
Slominski
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A
H. W. Toolan Institute for Medical Research, Bennington, VT 05201.
D000818:Animals; D004156:Catechol Oxidase / Q000096:biosynthesis*; D006224:Cricetinae; D007163:Immunosorbent Techniques; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism; D008970:Molecular Weight; D014442:Monophenol Monooxygenase / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D008543:Melanins; D014443:Tyrosine; D004156:Catechol Oxidase; D014446:Tyrosine 3-Monooxygenase; D014442:Monophenol Monooxygenase