Number of glucocorticoid receptors in lymphocytes and their sensitivity to hormone action.
The study demonstrated a decreased level of glucocorticoid receptors (GR) in peripheral blood lymphocytes from hypercholesterolemic subjects, and an elevated level in patients with acute myocardial infarction. In the lymphocytes with a high GR number, dexamethasone inhibited [3H]-thymidine and [3H]-acetate incorporation into DNA and cholesterol, respectively, in the same manner as in the control cells. On the other hand, a decreased GR number resulted in a less efficient dexamethasone inhibition of the incorporation of labeled compounds. These data showed that the sensitivity of lymphocytes to glucocorticoids changed only with a decrease of GR level.
Petrichenko
I E
IE
USSR Research Centre for Preventive Medicine, Moscow.
Shakhov YuA
Gratsianski
N A
NA
Aleshin
O I
OI
Chepurnenko
N V
NV
Perova
N V
NV
D000328:Adult; D002784:Cholesterol / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D003907:Dexamethasone / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D004247:DNA; D002784:Cholesterol