Effect of glucarolactam on low-dose nephrotoxicities of dibekacin and gentamicin in Fischer rats.
Intramuscular administration of dibekacin or gentamicin to Fischer rats at doses of 10, 20 and 40 mg/kg for 11 days gave polyuria, enzymuria and cytauria. These changes were suppressed completely or partially by the simultaneous administration of glucarolactam sodium or potassium salt. The ameliorating results were supported by serum and histopathological analyses on day 12. A rise in BUN and serum creatinine levels was partially or completely suppressed and histopathological scores were improved by co-administration of glucarolactam salts.
Kitasato
I
I
Research & Development, Meiji Seika Kaisha Ltd., Tokyo, Japan.
Niizato
T
T
Inouye
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003982:Dibekacin / Q000633:toxicity*; D005839:Gentamicins / Q000633:toxicity*; D005937:Glucaric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013400:Sugar Acids / Q000494:pharmacology*; D014563:Urodynamics / Q000187:drug effects
D005839:Gentamicins; D013400:Sugar Acids; C001845:D-glucaro-delta-lactam; D003982:Dibekacin; D007612:Kanamycin; D003404:Creatinine; D005937:Glucaric Acid