Adenine nucleotide changes in submandibular salivary glands of rats following isoproterenol or incisor tooth amputation.
Male rats (180-220 g) were injected daily with isoproterenol (2 mg/kg of body weight) for up to 6 days, or their incisor teeth were amputated on every other day for up to six amputations. The animals were subdivided into groups killed 12 or 24 h after the first or last intervention. In the development of sialadenosis caused by isoproterenol, the levels of ATP were greater (13-30%), while those of AMP were lower (13-19%) in the experimental groups. No variation was noted in ADP content. In tooth-amputated animals, only the five and six amputation subgroups showed higher values for ATP (approx. 17%), and ADP (12 and 15%, respectively). The inorganic phosphate level was lower in both experimental groups (between 11-28% for isoproterenol and 13-22% for amputation). Thus isoproterenol caused different metabolic responses in submandibular salivary glands from those induced by incisor amputation.
Nicolau
J
J
Department of Biochemistry, University of São Paulo, Brazil.
Ferreira
F D
FD
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007180:Incisor / Q000601:surgery*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D007545:Isoproterenol