Management of gastro-oesophageal reflux disease. Are there alternatives to omeprazole?
Several studies have clearly demonstrated that omeprazole is highly efficacious in the management of patients with gastro-oesophageal reflux disease. In particular, wherever H2-receptor antagonists fail to produce results--in patients with severe disease--omeprazole has been shown to be of major value. However, new alternatives are forthcoming; a new generation of more potent H2-receptor antagonists will be available, while 24 pH studies with high-dose ranitidine have shown that acid reflux is suppressed more efficiently than with standard doses. The prokinetic drug cisapride appears to be of importance, not only in the management of patients with mild reflux disease, but also of cases with severe disease when cisapride is combined with a H2-receptor antagonist. Such a combination could also be of value as an alternative to omeprazole in long-term therapy, since it has not yet been shown that indefinite treatment with omeprazole of patients with reflux disease will be safe. In addition, the value of long-term sucralfate, effective in short-term therapy, needs to be evaluated in patients with chronic reflux disease who will not be operated. In forthcoming studies, it will be advisable to incorporate 24-hour pH measurements to detect periods of nonacid suppression more accurately. The future of medical management of gastro-oesophageal reflux disease appears to be promising.
Meuwissen
S G
SG
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
Klinkenberg-Knol
E C
EC
D020117:Cisapride; D004334:Drug Administration Schedule; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013810:Therapeutic Equivalency
D006635:Histamine H2 Antagonists; D010880:Piperidines; D012702:Serotonin Antagonists; D009853:Omeprazole; D020117:Cisapride