[Intracavitary high-dose-rate-afterloading-radiotherapy in the esophagus of the pig].
The tolerance of sound esophageal mucosa to intracavitary high dose rate afterloading contact therapy with unique doses of 6 Gy and 12 Gy, respectively, was investigated in 15 pigs. Whereas no macroscopic or microscopic alterations of the mucosa are found after 6 Gy, a unique application of 12 Gy produces most severe side effects such as vascular occlusion due to fibrosis of the intima, formation of fistulas, and perforations of the esophagus wall. Future investigations will have to aim at the elaboration of schemes for dosage and fractionation.
Freund
U
U
Abteilung Röntgen- und Strahlentherapie, Universitätsklinik Freiburg.
Brambs
H J
HJ
Laaff
H
H
Roth
R
R
Bruggmoser
G
G
Wannenmacher
M
M
D000818:Animals; D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D004939:Esophageal Perforation / Q000209:etiology; D004947:Esophagus / Q000098:blood supply / Q000528:radiation effects*; D005355:Fibrosis; D009092:Mucous Membrane / Q000528:radiation effects; D011829:Radiation Dosage; D013552:Swine
Intrakavitäre High-Dose-rate-Afterloading-Strahlentherapie im Schweineösophagus.