[Senna-containing laxatives: excretion in the breast milk?].
The excretion of rhein, a cathartic with active metabolite from sennosides, was investigated in breast milk samples of 15 post-partum women for at least 24 h after the intake of a therapeutic dose (15 mg sennosides/day) of a standardized, fiber containing senna laxative (Agiolax). Rhein was analyzed by a HPLC-method with a lower limit of detection at 1 ng/ml rhein, taking into account a possible binding as monoglucuronide and monosulfate. Maximal concentrations up to 27 ng/ml and in 89% values below 10 ng/ml were measured. Related to the daily milk volume, 73% of the women excreted less than 2 ng rhein/day. Based on median values, 0.017% of the sennoside intake (calculated as rhein) was excreted in breast milk. The amount of rhein transmitted to the infant is therefore 0.3% of the rhein intake of the mother. This is far below the oral rhein dose necessary for inducing a laxative effect. Accordingly, none of the breast-fed infants (n = 8) showed any difference in stool consistency in comparison with the non breast-fed infants.
Faber
P
P
Frauenklinik Prosper-Hospital, Recklinghausen.
Strenge-Hesse
A
A
D000328:Adult; D000873:Anthracenes / Q000493:pharmacokinetics*; D002400:Cathartics / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008895:Milk, Human / Q000032:analysis*; D049590:Postpartum Period; D011247:Pregnancy; D000095322:Anthrones
D000873:Anthracenes; D002400:Cathartics; C055876:rhein-9-anthrone; D000095322:Anthrones
Sennahaltiges Laxans: Ubertritt in Muttermilch?