title: Spermidine level as a parameter in the treatment of patients with malignant melanoma.
abstract: Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay. Baseline values were normal in 17 courses, a doubling of plasma levels following chemotherapy occurred in 13 courses. There was no relation between the occurrence of a tumor response and an increase in spermidine levels nor between hematological toxicity or digestive tract toxicity and spermidine levels.
authors.forename: J M
authors.initials: JM
authors.lastname: Smit
authors.forename: H
authors.initials: H
authors.lastname: Jurjens
authors.forename: J
authors.initials: J
authors.lastname: Bouman
authors.forename: J
authors.initials: J
authors.lastname: Bijzet
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
authors.forename: M G
authors.initials: MG
authors.lastname: Woldring
authors.forename: N H
authors.initials: NH
authors.lastname: Mulder
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D013095:Spermidine / Q000097:blood*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014751:Vindesine
chemical_list: D001761:Bleomycin; D003609:Dactinomycin; D014747:Vinblastine; D003606:Dacarbazine; D014751:Vindesine; D013095:Spermidine