[Bone marrow transplantation (immunology, immunosuppression)].
Clinical effectiveness of bone marrow transplantation has been analyzed in 83 patients with aplastic anemia. Bone marrow of non-related donors with high degree of histocompatibility, according to the antigen system HLA of loci A, B, C and DR, was used. Freshly prepared bone marrow was transplanted in doses from 3.4 x 10(9) to 15 x 10(9) myelokaryocytes. Immunosuppression was provided by corticosteroid hormones and antithymocytic globulin. Complete or partial remission lasting for more than a year was recorded in 56 patients. Formed elements of the donor's blood were detected in the blood of 39% of the patients (the observation period lasted from 1 to 8 months). Symptoms of a secondary disease were observed in 29% of the patients. Significant changes in the cellular immunity parameters were recorded in all the patients investigated. The character of the time course of these changes may serve as a prognostic factor of myelotherapy effectiveness.
Shabalin
V N
VN
Serova
L D
LD
D000741:Anemia, Aplastic / Q000276:immunology / Q000601:surgery*; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D011182:Postoperative Care; D014181:Transplantation Immunology / Q000187:drug effects / Q000502:physiology*
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents
Transplantatsiia kostnogo mozga (immunologiia, immunodepressiia)]