title: Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood.
abstract: Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown to react with a population of human peripheral blood mononuclear cells. The population is similar to the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). The population also includes cells exhibiting the Leu 2 marker for suppressor/cytotoxic T cells. The results indicate a shared antigenicity between the nervous system and the immune system and may be relevant to the pathogenesis of demyelinating diseases.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dobersen
authors.forename: P
authors.initials: P
authors.lastname: Gascon
authors.forename: S
authors.initials: S
authors.lastname: Trost
authors.forename: J A
authors.initials: JA
authors.lastname: Hammer
authors.forename: S
authors.initials: S
authors.lastname: Goodman
authors.forename: A B
authors.initials: AB
authors.lastname: Noronha
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Shannessy
authors.forename: R O
authors.initials: RO
authors.lastname: Brady
authors.forename: R H
authors.initials: RH
authors.lastname: Quarles
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D009000:Monocytes / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein
chemical_list: D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein