[Development and clinical application of ICG clearance meter].
We have developed a finger-piece method that can indicates an accurate concentration of ICG based on the two wavelength spectrophotometry. Seventy-eight subjects were evaluated by this new method. The ICG clearance curve obtained from ICG clearance meter showed a rapid increase 20 or 40 seconds after the bolus injection. The curve decreased gradually, and increased again at 60 or 70 seconds. Plasma disappearance rate (PDR) by this method (XK ICG) was calculated by the at least square method from 600 data obtained from 5 to 15 minutes after the injection. There was a significant correlation between conventional PDR (KICG) and new method (XK ICG) also. We assume that this method have a possibility to discover new aspect of pharmacokinetics of ICG.
Ishigami
Y
Y
Miyoshi
E
E
Masuzawa
M
M
Katou
M
M
Terada
A
A
Okuyama
T
T
Tamura
K
K
Hatakenaka
M
M
Morita
H
H
Funahashi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008107:Liver Diseases / Q000175:diagnosis; D008111:Liver Function Tests / Q000295:instrumentation / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013053:Spectrophotometry
D007208:Indocyanine Green