title: Prediction of pulmonary arterial pressure in chronic obstructive pulmonary disease by radionuclide ventriculography.
abstract: Pulmonary arterial hypertension represents an important parameter for the assessment of the severity of chronic bronchitis. The measurement of the pulmonary arterial pressure, however, requires invasive techniques of limited routine use because of costs and associated risks. The aim of this study is to evaluate whether the 81mKr right ventricular ejection fraction and parameters derived from equilibrium 99mTc red blood cells' right ventricular curve allow a better estimation of PAP than the 99mTc RVEF. In 41 patients with severe chronic bronchitis, the linear correlation between PAP and 99mTc RVEF was -0.61 (p less than 0.001). None of the parameters derived from the right ventricular curve was better correlated to PAP than the 99mTc RVEF. In 16 other chronic bronchitis patients, the 81mKr RVEF correlated moderately to PAP. In conclusion, the alternative isotopic methods proposed in this work do not provide a reliable estimation of pulmonary arterial pressure in patients with chronic bronchitis.
authors.affiliation: Service of Internal Medicine and of Radio-Isotopes, Saint-Pierre University Hospital, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Mols
authors.forename: C H
authors.initials: CH
authors.lastname: Huynh
authors.forename: P
authors.initials: P
authors.lastname: Dechamps
authors.forename: N
authors.initials: N
authors.lastname: Naeije
authors.forename: M
authors.initials: M
authors.lastname: Guillaume
authors.forename: H
authors.initials: H
authors.lastname: Ham
mesh_terms: D001794:Blood Pressure; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011651:Pulmonary Artery / Q000503:physiopathology*; D015635:Radionuclide Ventriculography; D012720:Severity of Illness Index; D013318:Stroke Volume; D014655:Vascular Resistance