title: Estimation of minimum alveolar concentration (MAC) for halothane, enflurane and isoflurane in spontaneously breathing guinea pigs.
abstract: MAC for halothane, enflurane and isoflurane was determined in guinea pigs (Cavia porcellus) exposed to constant anesthetic concentrations (2.5 hours each) in a flow-through glass chamber. The following values were obtained (N = 8 for each anesthetic): 1.01 +/- 0.03 vol% for halothane, 2.17 +/- 0.04 vol% for enflurane, and 1.15 +/- 0.05 vol% for isoflurane. In guinea pigs, MAC for halothane and enflurane are similar to those reported for other rodents, while MAC for isoflurane is lower. The data indicate that guinea pigs possibly are more susceptible to isoflurane's anesthetic actions than other rodents.
authors.affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock.
authors.forename: A B
authors.initials: AB
authors.lastname: Seifen
authors.forename: R H
authors.initials: RH
authors.lastname: Kennedy
authors.forename: J P
authors.initials: JP
authors.lastname: Bray
authors.forename: E
authors.initials: E
authors.lastname: Seifen
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D004737:Enflurane / Q000032:analysis*; D006168:Guinea Pigs / Q000378:metabolism*; D006221:Halothane / Q000032:analysis*; D007530:Isoflurane / Q000032:analysis*; D008297:Male; D011650:Pulmonary Alveoli / Q000032:analysis*; D012119:Respiration
chemical_list: D004737:Enflurane; D007530:Isoflurane; D006221:Halothane