title: Cardiorespiratory effects of pressure controlled inverse ratio ventilation in severe respiratory failure.
abstract: Cardiorespiratory values were measured in nine patients with severe respiratory failure before and following initiation of pressure controlled inverse ratio ventilation (PC-IRV) at an inspiratory to expiratory ratio of 2:1. All patients showed increases in PaO2, with the mean PaO2 rising from 63 +/- 4 (mean +/- SEM) to 76 +/- 8 mm Hg. Peak inspiratory pressure fell from 44 +/- 4 to 39 +/- 2 cm H2O. There were no significant changes in any hemodynamic or oxygen metabolism variable associated with the institution of PC-IRV. In particular, no significant alteration in cardiac index, pulmonary artery pressures, oxygen delivery, oxygen consumption, or oxygen extraction ratio occurred with the use of PC-IRV. These results suggest that PC-IRV may be a useful ventilatory modality in the treatment of severe respiratory failure since it results in improvement in arterial oxygenation without any deterioration in hemodynamic or tissue oxygen metabolism parameters.
authors.affiliation: Department of Medicine, UCLA Medical Center.
authors.forename: E
authors.initials: E
authors.lastname: Abraham
authors.forename: G
authors.initials: G
authors.lastname: Yoshihara
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000503:physiopathology; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012129:Respiratory Function Tests; D014655:Vascular Resistance
chemical_list: D010100:Oxygen