[The effectiveness of antiplatelet therapy in ischemic cerebrovascular attacks in the chronic stage].
Sixty-nine patients, mean age 50.0 years with an ischaemic cerebrovascular attack in the carotid circulation were subjected since 1983 to a complete examination incl. cerebral angiography. Based on the case-history, clinical examination, evaluation of results of cerebral angiography, haematological examination focused on platelet aggregation and statistical evaluation, the author assessed the shortest necessary period of the use of antithrombocytic drugs. One year after the attack a significant effect of the use of these drugs was proved, after two years, however, the H0 hypothesis on the independence of the clinical condition and treatment cannot be refuted. Based on these results the author recommends that to these stabilised patients after two years from the attack drugs should not be administered as a matter of routine; the patients should be subjected to a clinical examination and examination of circulating platelet aggregates with the possibility to discontinue antithrombocytic treatment. The author discusses the method of W. U. Hoak for the evaluation of the effectiveness of antithrombocytic treatment.
Chrobocek
J
J
D001241:Aspirin / Q000627:therapeutic use; D002545:Brain Ischemia / Q000150:complications / Q000517:prevention & control*; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011379:Prognosis; D012008:Recurrence
D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D001241:Aspirin; D010431:Pentoxifylline
Ucinnost preventivní protidestickové lécby u cévních mozkových príhod ischemického charakteru v chronickém stadiu.