title: Analytical chemistry of chromium.
abstract: The determination of chromium in most biological materials is extremely difficult because of the very low levels present. Easily accessible samples, for example biological fluids such as serum, urine, etc., usually have chromium concentrations well below 1 ng g-1. The only widely available analytical method with sufficient sensitivity is graphite furnace atomic absorption spectrometry (GFAAS), yet values reported in the early literature were wildly divergent. Man appeared to be excreting several times the amount of chromium he was absorbing from his diet. This dilemma was resolved in 1978 when it was shown that all previous chromium analytical results were probably wrong (too high), due to limitations of the instrumentation used up until then. Subsequent instruments with improved background correction capabilities have removed this limitation. However, making determinations at the sub-parts-per-billion level remains a formidable task in terms of contamination control.
authors.affiliation: Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, MD 20705.
authors.forename: C
authors.initials: C
authors.lastname: Veillon
mesh_terms: D002857:Chromium / Q000032:analysis / Q000652:urine*; D006801:Humans; D008832:Microchemistry; D013054:Spectrophotometry, Atomic / Q000295:instrumentation / Q000379:methods
chemical_list: D002857:Chromium