Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits.
The influence of the dopamine D-1 receptor antagonist, SCH 23390, on thyrotropin-releasing hormone (TRH)-induced behaviour was assessed in adult male rabbits. SCH 23390 prevented the effects of TRH (100 micrograms i.c.v.), starting at a very low dose (0.01 mg/kg i.v.). This finding seems to indicate that dopamine D-1 receptors are involved in TRH-induced behaviour.
Popoli
P
P
Department of Pharmacology, Istituto Superiore di Sanitù, Rome, Italy.
Caporali
M G
MG
Scotti de Carolis
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000009:adverse effects / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D011817:Rabbits; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D014150:Antipsychotic Agents; D001552:Benzazepines; D013973:Thyrotropin-Releasing Hormone