title: Age-related changes in lipid peroxidation and protective enzymes in the central nervous system.
abstract: Brain homogenates were used to measure in vitro formation of thiobarbituric acid reactive substances (TBARS) in 5 CNS regions of 3, 12 and 22 month old male Fischer 344 rats. Glutathione peroxidase, catalase and superoxide dismutase activity in 105,000 x g supernatants of these homogenates was also measured. Results indicated that in vitro TBARS formation declined with age in all 5 areas studied. Glutathione peroxidase, catalase and superoxide dismutase activity did not change with age. Regional differences in the activity of glutathione peroxidase and catalase were noted.
authors.affiliation: Department of Neurology, University of Minn. School of Medicine, Minneapolis.
authors.forename: K A
authors.initials: KA
authors.lastname: Ansari
authors.forename: E
authors.initials: E
authors.lastname: Kaplan
authors.forename: D
authors.initials: D
authors.lastname: Shoeman
mesh_terms: D000367:Age Factors; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013482:Superoxide Dismutase / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D013858:Thiobarbiturates; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid