Neurotensin enhances estradiol induced DNA synthesis in immature rat uterus.
Systemic administration of Neurotensin, a tridecapeptide, in immature rats treated with estradiol benzoate significantly enhances uterine DNA synthesis as reflected by the incorporation of 3H-thymidine. The peptide may have a direct action on the uterus. Substance P, a related peptide, had no effect on uterine DNA synthesis.
Mistry
A
A
Vijayan
E
E
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D013373:Substance P; D009496:Neurotensin; D004958:Estradiol; D004247:DNA; D013936:Thymidine