Effects of intravenously administered 6-hydroxydopamine on the content of monoamines in the median eminence and neurointermediate lobe of the rat.
The effects of intravenous administration of 6-hydroxydopamine (6-OHDA) on the content of catecholamines in the median eminence and neurointermediate lobe was studied in male rats. The results confirmed previous findings of a depletion of catecholamines in both regions as a result of this lesion, although the magnitude of the effect was less than that revealed by fluorescence histochemistry. Administration of desipramine before 6-OHDA injection produced a more specific lesion, depleting dopamine but leaving noradrenaline unaffected.
Sheward
W J
WJ
Watts
A G
AG
Fink
G
G
Smith
G C
GC
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007275:Injections, Intravenous; D008297:Male; D008473:Median Eminence / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis; D016627:Oxidopamine; D010903:Pituitary Gland, Anterior / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D002395:Catecholamines; D006892:Hydroxydopamines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine