[Studies on enhancement of nonspecific resistance to infection by leptospiral lipopolysaccharide. II. The mechanisms of the nonspecific protective activity of the LPS].
Leptospiral lipopolysaccharide can enhance the nonspecific resistance of host to infection. By researching its mechanism, we found: (1) The phagocytic function of peritoneal macrophages of guinea pigs was strengthened by E-LPS and L-LPS; (2) L-LPS and E-LPS activated peritoneal macrophages of mice then enlarging the cell raji, and increase the quantity and activity of intracellular acid phosphatase. Relatively, the L-LPS might have a greater action in synthesis of the enzyme, while the E-LPS mainly enhanced the activity of the enzyme; (3) L-LPS and E-LPS appeared to be immunomodulant. When they were injected 3d after immunizing the mice with SRBC, immune adjuvant effect developed; however, if the injection of LPS was made 24h prior to the immunization, it would result in immunosuppression.
Zhou
W J
WJ
Nie
D K
DK
Wu
S H
SH
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007919:Leptospira; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects*
D008070:Lipopolysaccharides; D000135:Acid Phosphatase