[Effect of sisomicin on intestinal microflora and colonization resistance in rats and their offspring].
In experiments with Wistar female rats it was shown that after administration in the form of inhalations (10.87 mg/m3) sisomicin was present in the animal feces in a concentration of 26.6 micrograms/g. Prolonged exposure to the antibiotic during the pregnancy term led to changes in microbiocenosis of the animal large intestine which was observed even a month after the delivery. The progeny of the animals was characterized by the presence of significant numbers of aerobic bacteria resistant to sisomicin and potentially pathogenic gram-negative bacteria including various species of Proteus in the intestine, as well as by higher periods of persistence of Klebsiella indicator strains administered orally.
Anufrieva
R G
RG
Shenderov
B A
BA
D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D005260:Female; D007422:Intestines / Q000382:microbiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000382:microbiology*; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012853:Sisomicin / Q000506:poisoning*
D012853:Sisomicin
Vliianie sizomitsina na sostav kishechnoĭ mikroflory i kolo- nizatsionnuiu rezistentnos't krys i ikh potomstva.