Hemodynamic effects of dopexamine in patients following coronary artery bypass surgery.
Dopexamine is a new dopamine analogue, with combined agonist properties on dopamine receptors and the beta 2-adrenoceptor. The aim of this study was to evaluate the short-term hemodynamic effects of dopexamine at different dosage rates in postoperative coronary artery bypass (CABG) patients, especially with respect to the right ventricle, using a right ventricular ejection fraction pulmonary artery catheter. With a dose of 2 micrograms/kg/min of dopexamine, significant increases in heart rate (25%), cardiac index (33%), and right ventricular ejection fraction (20%) were observed. Pulmonary vascular resistance decreased with a dose over 1 microgram/kg/min (15%). Mean arterial blood pressure and pulmonary artery pressures were not affected. At 4 micrograms/kg/min, cardiac index was further increased. In conclusion, dopexamine could be beneficial to patients with a compromised right ventricle by lowering afterload and improving ventricular performance after CABG.
Poelaert
J I
JI
Department of Intensive Care, University of Amsterdam, The Netherlands.
Mungroop
H E
HE
Koolen
J J
JJ
Van den Berg
P C
PC
D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D001026:Coronary Artery Bypass; D004298:Dopamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000502:physiology*; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D016278:Ventricular Function, Right / Q000187:drug effects*
D000322:Adrenergic Agonists; C046318:dopexamine; D004298:Dopamine