Studies on the stability of t mutant of influenza virus.
The t 30 degrees C mutant of A Port Chalmers 1/73 (H3N2) influenza virus passaged in cotton rats was reisolated. The original mutant and the reisolated virus were compared, the following parameters being tested: NA activity, HA titer, sensitivity of NA and HA to proteolytic enzymes, detergents and temperature, and Michaelis constant of NA. No differences were found in the parameters tested, thus suggesting that features of the mutant remained stable after passage in the susceptible animal organism.
Brydak
L
L
D000818:Animals; D003411:Arvicolinae; D006386:Hemagglutination Tests; D006863:Hydrogen-Ion Concentration; D009154:Mutation; D009439:Neuraminidase / Q000032:analysis; D009975:Orthomyxoviridae / Q000201:enzymology / Q000502:physiology*; D013696:Temperature
D009439:Neuraminidase