[A spectrophotometric method of analysis of fusidic acid].
A spectrophotometric method for assay of fusidic acid is described. The method is based on reaction with a reagent consisting of acetic anhydride and concentrated sulfuric acid. Mathematical processing of the results of the main substance determination in fusidic acid preparations showed that the error did not exceed 2 per cent. Procedures for spectrophotometric assay of fusidic acid in control of the processes of its biosynthesis, isolation and purification were developed. The procedures provided control of the technological process of fusidic acid production.
Satarova
D E
DE
Korchagin
V B
VB
Stepushkina
V V
VV
Makarova
R A
RA
D000089:Acetic Anhydrides / Q000494:pharmacology; D004345:Drug Industry / Q000592:standards*; D005672:Fusidic Acid / Q000032:analysis* / Q000302:isolation & purification; D007202:Indicators and Reagents / Q000494:pharmacology; D008433:Mathematics; D011786:Quality Control; D013053:Spectrophotometry / Q000379:methods*; D013464:Sulfuric Acids / Q000494:pharmacology; D014586:USSR
D000089:Acetic Anhydrides; D007202:Indicators and Reagents; D013464:Sulfuric Acids; D005672:Fusidic Acid
Spektrofotometricheskiĭ metod opredeleniia fuzidievoĭ kisloty.