title: Colposcopic findings and intraepithelial neoplasia in diethylstilbestrol-exposed offspring. The Dutch experience.
abstract: Data from two regional diethylstilbestrol clinics for colposcopic evaluation of young women with a history of diethylstilbestrol exposure in utero are presented: A total of 224 subjects with a well-documented history were enrolled in this study. Structural anomalies of the cervix and vagina were found in 30%. Vaginal epithelial changes were colposcopically observed in 65%, including vaginal adenosis in 22%. The prevalence rate of abnormal cytologic findings in the study group was 9%. In half of these patients a low-grade intraepithelial neoplasia of the cervix and vagina was found. It was concluded that colposcopy in diethylstilbestrol-exposed offspring in inexperienced hands can result in many unnecessary biopsies. Therefore colposcopic examination should be performed by expert colposcopists in referral diethylstilbestrol centers.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: Helmerhorst
authors.forename: H J
authors.initials: HJ
authors.lastname: Wijnen
authors.forename: P
authors.initials: P
authors.lastname: Kenemans
authors.forename: G S
authors.initials: GS
authors.lastname: Tjioe
authors.forename: H H
authors.initials: HH
authors.lastname: Dijkhuizen
authors.forename: J J
authors.initials: JJ
authors.lastname: Calame
authors.forename: H G
authors.initials: HG
authors.lastname: Stolk
mesh_terms: D000328:Adult; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014621:Vagina / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004054:Diethylstilbestrol