18-Substituted steroids. Part 15. 6 beta-Hydroxylation of aldosterone by liver.
6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. Periodate degradation of the 6 beta-hydroxyaldosterone gave 6 beta-hydroxyaldosterone gamma-lactone, identical with a synthetic sample.
Kirk
D N
DN
Department of Chemistry, Queen Mary College, London, UK.
Burke
P J
PJ
Toms
H C
HC
Latif
S A
SA
Morris
D J
DJ
D000450:Aldosterone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000032:analysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D006908:Hydroxyprogesterones; C061772:11,18-epoxy-6-hydroxy-3-oxoandrost-4-ene-17,18-carbolactone; D000450:Aldosterone