title: Platelet serotonergic mechanisms and glomerulonephritis.
abstract: Proven cases (28) of glomerulonephritis (GN) were evaluated for clinico-biochemical profile, bleeding time, platelet count, platelet aggregation and platelet serotonergic mechanisms. Inordinate increase in platelet aggregation and altered platelet serotonergic mechanisms (reduced 5-HT, uptake, reduced intraplatelet 5-HT and increased plasma 5-HT) were demonstrated in some histopathological types of GN. The mechanisms and importance of these alterations have been discussed.
authors.forename: M K
authors.initials: MK
authors.lastname: Mitra
authors.forename: A K
authors.initials: AK
authors.lastname: Jain
authors.forename: R
authors.initials: R
authors.lastname: Misra
authors.forename: P P
authors.initials: PP
authors.lastname: Sethi
authors.forename: R N
authors.initials: RN
authors.lastname: Shukla
authors.forename: M
authors.initials: M
authors.lastname: Chandra
authors.forename: M
authors.initials: M
authors.lastname: Verma
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: K
authors.initials: K
authors.lastname: Shanker
mesh_terms: D001760:Bleeding Time; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood*; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000097:blood; D010974:Platelet Aggregation; D010976:Platelet Count; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
chemical_list: D012701:Serotonin