Serum and effluent lysozyme (muramidase) activity in CAPD patients.
The elevated serum lysozyme activity in 13 chronic renal failure patients (n = 26) dropped significantly during their first three months of CAPD and subsequently returned to initial levels. When compared with peritoneal mass transfer of lysozyme and serum creatinine levels, a distinct correlation was observed between these and the fluctuations in serum lysozyme activity recorded up to three years of CAPD (r = 0.319, P less than 0.05 and r = 0.425, P less than 0.025, respectively). A notable drop in the mass transfer of this low molecular weight protein took place after the first hour of dialysis. We concluded that long-term CAPD does not affect serum lysozyme activity and that passive loss across the peritoneal membrane could account for the lysozyme found in the effluent fluid.
Kagan
A
A
Division of Nephrology, Kaplan Hospital, Rehovot, Israel.
Bar-Khayim
Y
Y
Yaari
A
A
Fainaru
M
M
Resnitzky
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport; D015314:Dialysis Solutions / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000503:physiopathology
D015314:Dialysis Solutions; D009113:Muramidase