Cholecystokinin receptors mediate enhanced memory retention produced by feeding and gastrointestinal peptides.
Ingestion of food in mice following training on T-maze footshock avoidance enhanced memory retention when tested 7 days later. This eating-induced improvement of retention was blocked by a specific cholecystokinin antagonist, L-364,718. The cholecystokinin antagonist prevented enhancement of memory retention resulting from posttraining administration of the gastrointestinal hormones, cholecystokinin, bombesin or gastrin releasing peptide. L-364,718 neither impaired or improved retention when given alone. Specificity of the effect of L-364,718 was demonstrated by the failure of L-364,718 to block improved memory retention resulting from administration of arecoline and D-amphetamine. The studies provide evidence that activation of cholecystokinin receptors plays a physiological role in the mediation of meal-induced enhancement of memory retention.
Flood
J F
JF
Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Sepulveda, CA 91343.
Morley
J E
JE
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology; D001839:Bombesin / Q000494:pharmacology; D020109:Devazepide; D003913:Dextroamphetamine / Q000494:pharmacology; D004435:Eating; D019886:Gastrin-Releasing Peptide; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D010455:Peptides / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology
D001570:Benzodiazepinones; D005768:Gastrointestinal Hormones; D010455:Peptides; D011949:Receptors, Cholecystokinin; D001115:Arecoline; D019886:Gastrin-Releasing Peptide; D020109:Devazepide; D012844:Sincalide; D001839:Bombesin; D003913:Dextroamphetamine