Evidence for a major additive gene in ulcerative colitis.
Complex segregation analysis of 124 families with ulcerative colitis with two or more affected individuals suggests a rare additive major gene causing the disease with about 20% affected among the heterozygotes for the gene. There was no evidence for multifactorial inheritance.
Monsén
U
U
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Iselius
L
L
Johansson
C
C
Hellers
G
G
D003093:Colitis, Ulcerative / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D005810:Multigene Family; D009679:Nuclear Family; D010375:Pedigree