The hepatoprotective principle of Hypoestes triflora leaves.
Hypoestes triflora is frequently used in Rwandese native medicine to treat hepatic diseases. Premedication with a water extract of the leaves prevented the prolongation of the barbiturate sleeping time associated with carbon tetrachloride-induced liver damage in mice. The compound responsible for this protective activity was benzoic acid. Mice previously treated with benzoic acid also showed a significant diminution of the increased GOT and GPT levels seen after carbon tetrachloride administration.
Van Puyvelde
L
L
Centre Universitaire de Recherche sur la Pharmacopée et la Médecine Traditionnelle, Faculté des Sciences, Université Nationale du Rwanda, France.
Kayonga
A
A
Brioen
P
P
Costa
J
J
Ndimubakunzi
A
A
De Kimpe
N
N
Schamp
N
N
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001565:Benzoates / Q000302:isolation & purification; D019817:Benzoic Acid; D002252:Carbon Tetrachloride Poisoning; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010946:Plants, Medicinal; D012432:Rwanda; D012890:Sleep / Q000187:drug effects
D001565:Benzoates; D019817:Benzoic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010424:Pentobarbital