title: External irradiation plus curietherapy boost in 108 base of tongue carcinomas.
abstract: From 1960 to 1983, 108 patients underwent an association cobaltherapy plus curietherapy boost for a base of tongue carcinoma. This group included 18 T1 tumors, 39 T2, and 51 T3. Cobaltherapy was delivered to a dose of 45 Gy/4.5 weeks to the primary site and the neck. It was completed by an electron boost or a nodal surgery in case of initial nodal disease. Two techniques of Curietherapy were used: plastic tubes and guide-gutters. As most of these implants have been done before 1975, all the doses have been recalculated on the 85% isodose according to the Paris system. They varied from 22 to 88 Gy. The tolerance of the implantation was excellent. Five-year survival of the whole group is 26%. The local control rate is 85% for T1 tumors, 50% for T2, and 69% for T3. Despite the importance of cumulated doses, a few necrosis were observed. Considering the poor outlook of this cancer, its treatment by exclusive radiotherapy requires very high doses which can only be delivered without major sequellae or complication by a combination of cobaltherapy and curietherapy boost.
authors.affiliation: Département des Radiations, Institut Gustave Roussy, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: J
authors.initials: J
authors.lastname: Eskandari
authors.forename: Y
authors.initials: Y
authors.lastname: Son
authors.forename: A
authors.initials: A
authors.lastname: Gerbaulet
authors.forename: C
authors.initials: C
authors.lastname: Haie
authors.forename: G
authors.initials: G
authors.lastname: Mamelle
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
authors.forename: D
authors.initials: D
authors.lastname: Chassagne
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes