title: Serotonin in panic disorder: platelet uptake and concentration.
abstract: Platelet serotonin uptake and platelet serotonin concentrations were measured in 17 patients (5 males, 12 females) with panic attacks and 15 controls (8 males, 7 females). Higher Vmax values were found in the patient group compared with controls (65 +/- 7 vs. 47 +/- 3 pmol/10(8) platelets/min; p less than 0.05) while the affinity constant Km was not significantly different (0.6 +/- 0.1 vs. 0.5 +/- 0.1 microM). Platelet serotonin concentrations were not significantly different between the two groups (38 +/- 4 vs. 41 +/- 4 ng/10(8) platelets). These results confirm our earlier finding of increased serotonin uptake in patients with panic attacks and suggest that platelet serotonin levels are normal.
authors.affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.
authors.forename: I M
authors.initials: IM
authors.lastname: McIntyre
authors.forename: F K
authors.initials: FK
authors.lastname: Judd
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
authors.forename: T R
authors.initials: TR
authors.lastname: Norman
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005239:Fear; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D010200:Panic / Q000502:physiology*; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin