title: Effects of epidural analgesia on plasma calcitonin gene-related peptide.
abstract: The effects of epidural analgesia on plasma calcitonin gene-related peptide (CGRP) values during and after hysterectomy were investigated in 14 healthy patients. In seven patients who received general anaesthesia alone for pelvic surgery, there were no significant changes in plasma CGRP concentrations. In the remaining patients, who received extensive epidural blockade in addition to general anaesthesia, there were again no significant changes in plasma CGRP values. This was in spite of profound sympathetic blockade, as shown by marked hypotension and a significant decline in plasma catecholamines. The epidural group of patients showed the expected attenuation of the glucose, cortisol and growth hormone responses to surgery. The results show that circulating CGRP is unlikely to be involved in the modulation of peripheral vascular tone during pelvic surgery under either general or epidural anaesthesia.
authors.affiliation: Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: V E
authors.initials: VE
authors.lastname: Bythell
authors.forename: S
authors.initials: S
authors.lastname: Lacoumenta
authors.forename: L H
authors.initials: LH
authors.lastname: Breimer
authors.forename: S
authors.initials: S
authors.lastname: Brooks
authors.forename: J M
authors.initials: JM
authors.lastname: Burrin
authors.forename: G M
authors.initials: GM
authors.lastname: Hall
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D000768:Anesthesia, General; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006400:Hematocrit; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007044:Hysterectomy / Q000379:methods; D009638:Norepinephrine / Q000097:blood; D013874:Thiopental; D014655:Vascular Resistance / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D013006:Growth Hormone; D015740:Calcitonin Gene-Related Peptide; D013874:Thiopental; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine