Skin-conductance orienting response in chronic schizophrenics: the role of neuroleptics.
The primary aim of this study was to determine whether there is an association between neuroleptic treatment and skin-conductance orienting response (SCOR) nonresponding in chronic schizophrenics. In a design adapted to this purpose, we were unable to demonstrate a relationship between neuroleptics and nonresponding. Although inability to prove the null hypothesis precludes a claim that neuroleptic treatment and SCOR nonresponding are unrelated, internal evidence and prior studies strongly suggest that such a dissociation exists in most chronic schizophrenic nonresponders. We also found stable nonspecific and toxic skin conductance activity differences between SCOR "responders" and "nonresponders" on three occasions of testing. We interpret our results as bearing on state and trait issues in chronic schizophrenics.
Spohn
H E
HE
Coyne
L
L
Wilson
J K
JK
Hayes
K
K
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002908:Chronic Disease; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects*; D006801:Humans; D008297:Male; D009949:Orientation / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology; D012559:Schizophrenia / Q000503:physiopathology*
D014150:Antipsychotic Agents; D010276:Parasympatholytics