Inhibition by vecuronium of carbachol-induced influx of 22Na+, 45Ca2+ and secretion of catecholamines in cultured bovine adrenal medullary cells.
In cultured bovine adrenal medullary cells, vecuronium, pancuronium and D-tubocurarine reduced carbachol-induced 45Ca2+ influx and catecholamine secretion by inhibiting 22Na+ influx via nicotinic receptor-ion channel complex with IC50 values of 0.43, 7.6 and 3.9 mumol/l, respectively. IC50 values of pancuronium and D-tubocurarine observed in adrenal medulla were one order of magnitude higher than the plasma concentrations of these muscle relaxants reported to produce 50% neuromuscular blockade, while IC50 of vecuronium was quite close between adrenal medulla and skeletal muscle.
Wada
A
A
Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Arita
M
M
Takara
H
H
Sumikawa
K
K
Uezono
Y
Y
Izumi
F
F
D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002217:Carbachol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002478:Cells, Cultured; D010197:Pancuronium / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D012979:Sodium Radioisotopes; D014403:Tubocurarine / Q000494:pharmacology; D014673:Vecuronium Bromide / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D002395:Catecholamines; D012979:Sodium Radioisotopes; D014673:Vecuronium Bromide; D002217:Carbachol; D012964:Sodium; D010197:Pancuronium; D002118:Calcium; D014403:Tubocurarine