[Changes in the neuronal membrane potential of the mollusk Planorbarius corneus under the action of cardiac glycosides].
In experiments on isolated neurones from the gastropod mollusc P. corneus, strophantin and digoxin in low concentrations produce slow hyperpolarization, in higher ones--depolarization; at concentrations about 1 mM, hyperpolarization was more evident. In all cases, the decrease in membrane resistance was observed. Presumably, membrane permeability for potassium ions increases. During application of the drugs in concentrations 10-100 microM, hyperpolarization may be masked by depolarization due to block of Na,K-pump. Higher concentrations, increasing potassium permeability of the membrane, may result in substitution of depolarization by hyperpolarization.
Gapon
S A
SA
Kachman
A N
AN
Mikhaĭlov
I B
IB
Frolov
E V
EV
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004077:Digoxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008974:Mollusca / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013328:Strophanthins / Q000494:pharmacology
D002301:Cardiac Glycosides; D013328:Strophanthins; D004077:Digoxin
Izmenenie membrannogo potentsiala neĭronov molliuska Planorbarius corneus pri deĭstvii serdechnykh glikozidov.