title: [The pathogenesis of heart rupture in myocardial infarct].
abstract: Examination of 166 patients with primary transmural myocardial infarction (MI) of the anterior site has shown that the blood of MI patients (n = 34) complicated by cardiorrhexis manifests the maximal increase of the stress reaction components, lipid peroxidation products and an appreciable lowering of the content of adaptogens. It is emphasized that the development of the maladaptation syndrome underlies the pathogenesis of cardiorrhexis during MI as the result of the failure of the compensatory-adaptive potentialities of the body in response to the excessive stress reaction. It has been discovered that the high rise of the ST segment on the ECG and pronounced arterial hypoxemia are informative indicators mirroring the high probability of cardiorrhexis occurrence in MI patients. A scheme of cardiorrhexis pathogenesis in MI patients is offered.
authors.forename: A P
authors.initials: AP
authors.lastname: Golikov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Polumiskov
authors.forename: M M
authors.initials: MM
authors.lastname: Luk'ianov
authors.forename: B V
authors.initials: BV
authors.lastname: Davydov
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D001784:Blood Gas Analysis; D004562:Electrocardiography; D013006:Growth Hormone / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006341:Heart Rupture / Q000097:blood* / Q000175:diagnosis; D006342:Heart Rupture, Post-Infarction / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007330:Insulin Antibodies / Q000032:analysis; D008054:Lipid Peroxides / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D007330:Insulin Antibodies; D008054:Lipid Peroxides; D014810:Vitamin E; D013006:Growth Hormone; D006854:Hydrocortisone
vernacular_title: O patogeneze razryva serdtsa pri infarkte miokarda.