[Retinal vascular beta-adrenergic receptors in man].
Beta-blockers are widely used in the primary open angle glaucoma treatment. The molecular mechanism by which these drugs reduce intraocular pressure is essentially based on the blockade of beta-adrenergic receptors localized on the ciliary processes. Vascular effects of beta-blockers, which are difficult to exhibit clinically, have been recently reported for some drugs with intrinsic sympathomimetic activity. In this study, we attempted to investigate the presence of beta-adrenergic specific binding sites on the human retinal vessels, by means of an in vitro autoradiographic technique. These receptors are localized both on arteries and veins; displacement studies indicated that they are mainly of beta-2 subtype.
Denis
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P
Elena
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PP
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000187:drug effects; D012171:Retinal Vessels / Q000032:analysis* / Q000000981:diagnostic imaging
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta
Récepteurs bêta-adrénergiques vasculaires rétiniens chez l'homme.