An inducible endothelial cell surface glycoprotein mediates melanoma adhesion.
Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothelial cell surface glycoprotein, designated INCAM-110, appears to mediate adhesion of melanoma cells. In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line. Thus, activation of vascular endothelium in vivo that results in increased expression of INCAM-110 and ELAM-1 may promote tumor cell adhesion and affect the incidence and distribution of metastases.
Rice
G E
GE
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Bevilacqua
M P
MP
D000818:Animals; D000911:Antibodies, Monoclonal; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000502:physiology*; D003110:Colonic Neoplasms / Q000473:pathology; D004730:Endothelium, Vascular / Q000032:analysis / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008546:Melanoma, Experimental / Q000473:pathology; D008970:Molecular Weight; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules