Fibrous bodies in growth hormone-secreting adenomas contain cytokeratin filaments.
Fibrous bodies in growth hormone-secreting adenomas were studied by immunocytochemistry using an anti-cytokeratin antiserum. Fibrous bodies are a feature of acidophil and chromophobe adenomas and are usually associated with acromegaly. Ultrastructural examination revealed round juxtanuclear filamentous aggregates, composed of 8-nm filaments and other organelles. This study demonstrated that the intermediate filaments of fibrous bodies belong to the cytokeratin class. The etiology and significance of these filamentous aggregates remain obscure.
Neumann
P E
PE
Goldman
J E
JE
Horoupian
D S
DS
Hess
M A
MA
D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D009940:Organoids / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
D007633:Keratins; D013006:Growth Hormone