[Modifying effect of the chemical components of dust on the induction of lung tumors by physical and chemical carcinogens (experimental study].
Chronic inhalation intake of benzo(a)pyrene (BP) and polonium-210 (210Po) together with aluminum oxide caused increase of tumor formation in the lungs of mice. Synergy of BP and 210Po carcinogenic effect was pointed out, it was characterized by summation and possible effect involution by tumor development rates and the duration of the latent period. BP and 210Po carcinogenic effectiveness depended on the type of dust carrier and probably on the presence of silicon dioxide and also carcinogenic metals. It was pointed out that further studies were necessary to determine an etiologic role of mineral dust chemical components in carcinogenic activity of the above substances and also carcinogenic effectiveness of dusts as carriers of chemical carcinogens and alpha-active radionuclides.
Knizhnikov
V A
VA
Komleva
V A
VA
Nifatov
A P
AP
Novoselova
G P
GP
Molokanov
A A
AA
D000280:Administration, Inhalation; D000535:Aluminum / Q000009:adverse effects*; D000537:Aluminum Oxide / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000009:adverse effects*; D003043:Cocarcinogenesis; D004357:Drug Synergism; D004391:Dust / Q000009:adverse effects; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000528:radiation effects; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011059:Polonium / Q000008:administration & dosage / Q000009:adverse effects*
D004391:Dust; D001564:Benzo(a)pyrene; D000535:Aluminum; D011059:Polonium; D000537:Aluminum Oxide
O modifitsiruiushchem vliianii khimicheskikh komponentov pyli na induktsiiu opukholeĭ legkogo fizicheskim i khimicheskim kantserogenom (éksperimenta'lnoe issledovanie).