Effect of intracerebrally injected aminophylline, vinpocetinum, vasoactive intestinal peptide and onion extract on breathing pattern of rats.
Aminophylline or VIP (Vasoactive Intestinal Peptide) given ip. or iv. have marked bronchodilatory effects. The onion extracts protect guinea pigs as well as human patients against allergen-induced bronchial spasms (Dorsch et al.). Recently it has been shown that lipophilic components of onions seem to be responsible for the antiasthmatic effects. The purpose of this study was to investigate the effect of intracerebrally injected aminophylline (3 microM), Vinpocetinum (0.1 mg/kg), VIP (5 micrograms) and onion oils (30 microliters of extracts) on the respiratory center and on the resistance of lower airways of rats. The following respiratory parameters were evaluated: respiratory rate (RR), tidal volume (VT), mean inspiratory flow (Vin), respiratory minute volume (VE), and dynamic lung resistance (R). Respiratory rate was increased and values of all the other parameters were decreased after aminophylline treatment. VIP increased the tidal volume, minute ventilation and the respiratory drive. After injection of onion extracts the respiratory rate and the dynamic lung resistance decreased, but the tidal volume increased. The beneficial effects of onion oil are manifested not only peripherally acting on bronchial smooth muscle but via the reflexogenic pathways.
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Pathophysiological Research Unit, National Koranyi Institute for TBC and Pulmonology, Budapest/Hungary.
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D000403:Airway Resistance / Q000187:drug effects*; D000490:Allium / Q000032:analysis; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D008176:Lung Volume Measurements; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D012123:Pulmonary Ventilation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012125:Respiratory Center / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D010936:Plant Extracts; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; D000628:Aminophylline; D014660:Vasoactive Intestinal Peptide; C013983:vinpocetine