Rapid chromosome analysis with the use of spontaneously dividing cells derived from umbilical cord blood (fetal and neonatal).
An accurate and reproducible method to obtain high-quality metaphases within 24 hours has been developed. Preparations can be derived from cord blood samples obtained either at delivery or by percutaneous umbilical blood sampling. Mitogens are not required. Rapid cytogenetic analysis can facilitate management of pregnancies characterized by malformations or intrauterine growth retardation.
Tipton
R E
RE
Department of Pediatrics, University of Tennessee, Memphis.
Tharapel
A T
AT
Chang
H H
HH
Simpson
J L
JL
Elias
S
S
D002455:Cell Division; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008677:Metaphase; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*