Uptake of [3H]dopamine in the mouse adrenal medulla during dark and light period.
Uptake of exogenous [3H]dopamine in adrenal chromaffin cells of the mouse was studied by autoradiography under a 12-h light, 12-h dark cycle. The uptake of [3H]dopamine in adrenal chromaffin cells was markedly decreased in the dark period. The decrease was prevented by adrenal denervation. It is postulated that there is a neurally mediated suppression of [3H]dopamine uptake by adrenal chromaffin cells in the dark period. Adrenaline-storing (A) cells are more sensitive to the decreased sympathetic activity than noradrenaline-storing (NA) cells while increased sympathetic activity non-selectively affects both types of adrenal chromaffin cells.
Hirano
T
T
Department of Physiology, Niigata University Medical School, Japan.
Nagai
K
K
Bando
T
T
Nakagawa
H
H
Niijima
A
A
D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002838:Chromaffin System / Q000166:cytology / Q000378:metabolism; D003624:Darkness; D004298:Dopamine / Q000378:metabolism*; D008027:Light; D008297:Male; D051379:Mice; D010507:Periodicity; D014316:Tritium
D014316:Tritium; D004298:Dopamine