title: Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.
abstract: The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced urotoxicity of CPA. In contrast, simultaneous administration of DSF (200 mg/kg, p.o.) decreased the urotoxicity of CPA.
authors.affiliation: Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide / Q000633:toxicity*; D004221:Disulfiram / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000963:Antimetabolites; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide; D005978:Glutathione; D004221:Disulfiram