Gross genetic differences among substrains of NZB mice.
Substrains of NZB mice have been compared by Southern blot analysis using several probes. The restriction fragment length polymorphism of probes derived from the Igh-V, Igk-V, Tcr alpha-C loci and of the long terminal repeat of the mouse mammary tumour virus revealed that NZB/BlLwPtIbm were grossly different from NZB/BlNJ and NZB/BlOla. Comparison with mouse strains of the Igk-V haplotypes a and d suggested that NZB/BlLwPtIbm contain genetic material of the C58 mouse strain.
Weiss
S
S
Basel Institute for Immunology, Basel, Switzerland.
Uematsu
Y
Y
D'Hoostelaere
L
L
Alanen
A
A
D000818:Animals; D005803:Genes, Immunoglobulin / Q000235:genetics; D006239:Haplotypes; D008099:Liver / Q000032:analysis; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000276:immunology; D008815:Mice, Inbred Strains / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D013045:Species Specificity
D011948:Receptors, Antigen, T-Cell