title: Serum dopamine-beta-hydroxylase activity in clinical subtypes of depression.
abstract: Serum dopamine-beta-hydroxylase (DBH) activity was determined in male adult psychiatric patients (n = 280) and age-matched male healthy controls (n = 100). Patients included in the study had no history of previous or current exposure to psychoactive drugs and were diagnosed according to Research Diagnostic Criteria. A significant decrease in serum DBH activity was noted in patients with psychotic major depressive disorder (n = 50) as compared with controls. In acute schizophrenics (n = 100), nonpsychotic major depressives (n = 45) and patients with manic disorder (n = 85), mean DBH activity did not differ significantly from the control values.
authors.affiliation: Department of Neurochemistry and Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Sapru
authors.forename: B S
authors.initials: BS
authors.lastname: Rao
authors.forename: S M
authors.initials: SM
authors.lastname: Channabasavanna
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000201:enzymology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000201:enzymology; D003937:Diagnosis, Differential; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis* / Q000201:enzymology
chemical_list: D004299:Dopamine beta-Hydroxylase