title: The coiled-coil molecules of intermediate filaments consist of two parallel chains in exact axial register.
abstract: Amino acid sequence studies of helical particles derived from proteolytic digests of mouse epidermal keratin intermediate filaments (IF) have shown that their coiled-coil molecules are heterodimers of Type I and Type II keratins, with a parallel arrangement of the two chains. From a reappraisal of published chemical cross-linking data, it is concluded that the coiled-coil molecules in all IF consist of pairs of parallel chains in precise axial register.
authors.forename: D A
authors.initials: DA
authors.lastname: Parry
authors.forename: A C
authors.initials: AC
authors.lastname: Steven
authors.forename: P M
authors.initials: PM
authors.lastname: Steinert
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003599:Cytoskeleton / Q000648:ultrastructure*; D004817:Epidermis / Q000648:ultrastructure*; D007633:Keratins; D046911:Macromolecular Substances; D051379:Mice; D011487:Protein Conformation
chemical_list: D046911:Macromolecular Substances; D007633:Keratins