[Characteristics of the action of modified atherogenic-class lipoproteins on the functional activity of peripheral blood lymphocytes in patients with ischemic heart disease].
In a study of the effect of lipoproteins of atherogenic classes on proliferative activity of peripheral lymphocytes in patients (n = 44) with ischemic heart disease (IHD) and healthy subjects (n = 16), VLDL isolated from hyperlipidemia blood were shown to have a more suppressive effect on proliferation of PHA-induced lymphocytes than those from healthy subjects. Effect analysis of VLDL isolated from patients with different hyperlipidemia types revealed that VLDL obtained from high triglyceride plasma depressed proliferation 85-75%, while VLDL withdrawn from high cholesterol plasma 45-55% (p less than 0.05). With addition of modified (oxidized) VLDL to PHA-activated lymphocytes oxidized VLDL were demonstrated to have a greater inhibitory effect as compared with intact VLDL. The observed peculiarities of the VLDL effect in hyperlipidemia may underlie the reduced functional activity of lymphocytes, discovered in IHD patients (n = 81).
Vasil'chenko
E M
EM
Beĭko
V A
VA
Karpov
R S
RS
Kanskaia
N V
NV
D000787:Angina Pectoris / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D005082:Physical Exertion; D010835:Phytohemagglutinins / Q000494:pharmacology
D008079:Lipoproteins, VLDL; D010835:Phytohemagglutinins
Osobennosti deĭstviia modifitsirovannykh lipoproteidov aterogennykh klassov na funktsional'nuiu aktivnost' limfotsitov perifericheskoĭ krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa.