title: The development expression of alpha-, mu- and pi-class glutathione S-transferases in human liver.
abstract: The developmental expression of the alpha, mu and pi class glutathione S-transferases has been defined in human liver using radioimmunoassay and immunohistochemistry. Expression of alpha and mu class isoenzymes increased significantly at birth, while that of the pi isoenzyme declined during the first trimester. Mu-class isoenzymes (GST1 1, GST1 2, GST1 2-1) were expressed in hepatocytes but not in other liver cell types.
authors.affiliation: Clinical Biochemistry Research Laboratory, School of Postgraduate Medicine and Biological Sciences, University of Keele, Hartshill, Stoke-on-Trent, U.K.
authors.forename: R C
authors.initials: RC
authors.lastname: Strange
authors.forename: A F
authors.initials: AF
authors.lastname: Howie
authors.forename: R
authors.initials: R
authors.lastname: Hume
authors.forename: B
authors.initials: B
authors.lastname: Matharoo
authors.forename: J
authors.initials: J
authors.lastname: Bell
authors.forename: C
authors.initials: C
authors.lastname: Hiley
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: G J
authors.initials: GJ
authors.lastname: Beckett
mesh_terms: D000375:Aging / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D005865:Gestational Age; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000196:embryology / Q000201:enzymology / Q000254:growth & development*; D010641:Phenotype; D011863:Radioimmunoassay
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase