title: Inherited deficiencies of the late-acting complement components other than C9 found among healthy blood donors.
abstract: Among sera from 145,640 healthy blood donors in Osaka, 16 were found to have abnormalities in late-acting complement components other than C9. It was found that of these 16 sera, 2 were deficient in C5, 4 in C6, 6 in C7 and 4 in C8 alpha-gamma-subunit. The incidence of deficiency of each component among the Osaka blood donors was calculated as follows: C5 deficiency, 0.0014%; C6 deficiency, 0.0027%; C7 deficiency, 0.0041%; C8 alpha-gamma-subunit deficiency, 0.0027%. We confirmed that 13 donors were healthy and 12 had no past history related to a complement component deficiency. From these results, not only C9 deficiency but also deficiencies of the other late-acting complement components were found among the healthy blood donors, but no early-acting component deficiencies were noted.
authors.affiliation: Department of Clinical Pathology, Osaka Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Inai
authors.forename: Y
authors.initials: Y
authors.lastname: Akagaki
authors.forename: T
authors.initials: T
authors.lastname: Moriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumori
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Ohnoki
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D001782:Blood Donors; D003167:Complement Activation; D003182:Complement C5 / Q000172:deficiency / Q000235:genetics; D003183:Complement C6 / Q000172:deficiency; D003184:Complement C7 / Q000172:deficiency; D003185:Complement C8 / Q000172:deficiency; D003186:Complement C9 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D006461:Hemolysis; D006801:Humans; D007564:Japan; D010375:Pedigree
chemical_list: D003182:Complement C5; D003183:Complement C6; D003184:Complement C7; D003185:Complement C8; D003186:Complement C9; D003165:Complement System Proteins