The effect of cyanide on the K-current in guinea-pig ventricular myocytes.
The mechanism of the shortening of the cardiac action potential by cyanide was studied in guinea-pig ventricular myocytes using a two micro-electrode voltage clamp technique. It is shown that the shortening can be counteracted by glucose and is due to a marked increase in K conductance.
Van der Heyden
G
G
Vereecke
J
J
Carmeliet
E
E
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002478:Cells, Cultured; D003486:Cyanides / Q000494:pharmacology*; D004562:Electrocardiography; D004734:Energy Metabolism / Q000187:drug effects*; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000166:cytology*; D010100:Oxygen / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D012966:Sodium Cyanide / Q000494:pharmacology*
D001786:Blood Glucose; D003486:Cyanides; D007473:Ion Channels; D012966:Sodium Cyanide; D011188:Potassium; D010100:Oxygen