Novel antifungal antibiotics maniwamycins A and B. I. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological properties.
Two antifungal antibiotics maniwamycins A and B were isolated from the culture broth of a strain of actinomycetes, which were classified as Streptomyces prasinopilosus. These antibiotics were isolated by resin absorption and extraction with EtOAc and purified by column chromatography. Both antibiotics were found to be new azoxy substances from their physico-chemical properties. They showed broad antifungal spectra.
Nakayama
M
M
Tokyo Research Laboratories, Kowa Co., Ltd., Japan.
Takahashi
Y
Y
Itoh
H
H
Kamiya
K
K
Shiratsuchi
M
M
Otani
G
G
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D001391:Azo Compounds / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000935:Antifungal Agents; D001391:Azo Compounds; C061860:maniwamycin B; C061859:maniwamycin A