The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21.
Prompted by the observed co-amplification at the DNA level of the int.2 and hst fibroblast growth factor-related oncogenes in some tumor cells, we have investigated the precise localization of these two loci known to reside in band q13 of chromosome 11. We demonstrate by pulsed field gel analysis that these two genes are separated by only 40 kb, locate three HTF islands in their neighbourhood, and show that the bcl.1 locus (translocation breakpoint in B-cell proliferative malignancies) is not more than 1050 kb away. We also show that the fgf.5 gene which belongs to the same family is not part of this cluster and is located in band q21 of chromosome 4.
Nguyen
C
C
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
Roux
D
D
Mattei
M G
MG
de Lapeyriere
O
O
Goldfarb
M
M
Birnbaum
D
D
Jordan
B R
BR
D002460:Cell Line; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D003001:Cloning, Molecular; D005346:Fibroblast Growth Factors / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D009857:Oncogenes; D015183:Restriction Mapping
D005346:Fibroblast Growth Factors