Experimental allergic encephalomyelitis in guinea pigs. Influence of thymosin fraction V on the disease.
Experimental allergic encephalomyelitis (EAE) was induced in strain 13 guinea pigs by sensitization with 10 micrograms of myelin basic protein (BP) in complete Freund's adjuvant (CFA). These animals were treated with saline or with thymosin factor V in 3 different doses in 3 separate experiments. Thymosin had no suppressive effect on the incidence and severity of EAE.
Woyciechowska
J
J
Goldstein
A L
AL
Driscoll
B
B
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D005620:Freund's Adjuvant / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000188:drug therapy; D004676:Myelin Basic Protein / Q000494:pharmacology; D013947:Thymosin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004676:Myelin Basic Protein; C033782:thymosin fraction 5; D013947:Thymosin; D005620:Freund's Adjuvant