[The effect of gangliosides on experimental influenza infection].
Experiments in two strains of mice; CBA, susceptible to influenza, and CBAXC57Bl/cXFl, resistant to it, demonstrated stimulation of influenza infection caused by gangliosides. The stimulating effect of gangliosides (GMl, GDla, GTlb) seems to be explained by their insertion into plasma membranes of epithelial cells of the respiratory tract and by an increase, due to it, of the number of superficial virus-specific receptors.
Bukrinskaia
A G
AG
Petrova
I G
IG
Podcherniaeva
R Ia
RIa
Slepushkin
V A
VA
Bergel'son
L D
LD
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D005732:Gangliosides / Q000494:pharmacology* / Q000627:therapeutic use; D009980:Influenza A virus / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D012137:Respiratory System / Q000187:drug effects / Q000382:microbiology
D005732:Gangliosides
Vliianie gangliozidov na éksperimental'nuiu grippoznuiu infektsiiu.