Glia maturation factor-beta promotes the appearance of large neurofilament-rich neurons in injured rat brains.
Adult rat brains were injured by partial decortication. Glia maturation factor-beta (GMF-beta) was applied to the wound cavity 3 times over a period of two months. At the end of the experiment, brain sections were prepared and immunostained for neurofilaments. Large, neurofilament-rich neurons were observed in clusters in the brain tissue adjacent to the wound cavity. These neurons displayed prominent apical dendrites, some of which grew out branches toward the direction of the wound. The results suggest that GMF-beta promotes the hypertrophy of selective neurons in the injured cerebral cortex and implies a role for GMF-beta in central nervous system regeneration.
Lim
R
R
Department of Neurology, University of Iowa College of Medicine, Iowa City.
Huang
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LB
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology*; D002452:Cell Count; D003599:Cytoskeleton / Q000187:drug effects*; D020904:Glia Maturation Factor; D007382:Intermediate Filaments / Q000187:drug effects*; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D020904:Glia Maturation Factor; D009419:Nerve Tissue Proteins