title: Splenic hypofunction in systemic lupus erythematosus: response to pneumococcal vaccine.
abstract: A woman who presented with splenic hypofunction as a complication of systemic lupus erythematosus is described. Pneumococcal vaccine was given. Her antibody response was measured and the responses of other cases are discussed.
authors.affiliation: Department of Medicine, Sunnybrook Medical Centre, Toronto, ON, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Poldre
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001284:Atrophy / Q000209:etiology; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D022242:Pneumococcal Vaccines; D013154:Spleen / Q000473:pathology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines