HeLa cells have histamine H1-receptors which mediate activation of the K+ conductance.
HeLa cells responded to exogenous histamine with a transient hyperpolarization due to increased membrane conductance to K+. After successive applications of histamine, the cell membrane became virtually unresponsive (desensitized). The responses were blocked by pyrilamine but not by cimetidine. Thus, it appears that HeLa cells have H1-receptors which mediate an increase in the K+ conductance.
Hazama
A
A
Yada
T
T
Okada
Y
Y
D002462:Cell Membrane / Q000502:physiology; D002927:Cimetidine / Q000494:pharmacology; D004553:Electric Conductivity; D004558:Electric Stimulation; D006367:HeLa Cells / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D011738:Pyrilamine / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology*
D007473:Ion Channels; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D002927:Cimetidine; D006632:Histamine; D011803:Quinine; D011738:Pyrilamine; D011188:Potassium