title: The use of a biological adhesive to achieve sutureless epikeratophakia.
abstract: An adhesive made of concentrated human fibrinogen produced from samples of single donor blood by a simple cryoprecipitation method was tested for its ability to bond lamellar corneal buttons in vitro and found to have a bond strength of 140 gm/cm2. The adhesive was successfully used to attach experimental epikeratophakia grafts in a rabbit model. The results were similar to those reported from an earlier trial using a commercially available adhesive prepared from pooled multi-donor human plasma. This experimental trial of single-donor adhesive demonstrates the possibility of successful use of autologous fibrinogen adhesive in human epikeratophakia. Autologous adhesive would remove the possible threat of transmitted disease posed by multi-donor adhesive and avoid immune reactions to foreign proteins.
authors.affiliation: Department of Ophthalmology, Leicester Royal Infirmary.
authors.forename: G P
authors.initials: GP
authors.lastname: Brittain
authors.forename: C K
authors.initials: CK
authors.lastname: Rostron
authors.forename: D B
authors.initials: DB
authors.lastname: Morton
authors.forename: J E
authors.initials: JE
authors.lastname: Rees
mesh_terms: D000818:Animals; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation / Q000379:methods*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D014014:Tissue Adhesives
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives