[Comparative evaluation of the lipid metabolic indices of children with a hereditary predisposition for diabetes and in manifest diabetes mellitus].
The paper is concerned with the results of investigation of serum lipid, phospholipid and lipoprotein spectra in 31 sibs, 100 children with diabetes mellitus (DM), 83 women in birth with DM and their fetuses. This study showed a necessity of planned investigation of sibs not only for the detection of glucose tolerance but also of primary and secondary dyslipemia. In children with manifest DM the ratio of lipid, phospholipid and lipoprotein fractions was disturbed and depended upon a degree of compensation, a period of disease and a dose of insulin. The type of changes in the women in birth with DM was the same as during pregnancy: there was an increase in the concentration of total lipids and some of their fractions: nonesterified fatty acids, triglycerides, cholesterol, and atherogenic lipoproteins. Liposynthetic activation observed in infants born to DM mothers, was associated with the metabolic effects of insulin, of which a degree of hypersecretion seemed to determine the type of lipidograms.
Marchenko
L F
LF
Turkina
T I
TI
Sapelkina
L V
LV
Skripkina
V M
VM
Andreĭchenko
A P
AP
D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000235:genetics; D004198:Disease Susceptibility / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D011247:Pregnancy
D008055:Lipids; D008074:Lipoproteins
Sravnitel'naia otsenka pokazateleĭ obmena lipidov u deteĭ s nasledstvennoĭ predraspolozhennost'iu k diabetu i pri iavnom sakharnom diabete.