title: Repeated application of EMLA cream 5% for the alleviation of cannulation pain in haemodialysis.
abstract: The analgesic effect and the occurrence of local reactions after repeated application of a lidocaine/prilocaine cream (EMLA 5%) were investigated in 31 haemodialysis patients. The cream was used for alleviation of cannulation pain prior to the haemodialysis (HD) for a period of 1-1.5 years. In each patient 300 to 312 applications of the cream were made during the period. Local skin reactions were recorded after the cream applications and the analgesic effect was evaluated with double-blind, crossover placebo controls at regular intervals. Seventeen patients completed the study. EMLA gave considerable pain relief and was significantly better than placebo at all effect evaluations but one. The frequency of local reactions was low and not correlated to the number of applications of EMLA. Two patients, however, interrupted their treatment due to local irritation.
authors.affiliation: Department of Renal Medicine, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Wehle
authors.forename: M
authors.initials: M
authors.lastname: Björnström
authors.forename: M
authors.initials: M
authors.lastname: Cedgård
authors.forename: K
authors.initials: K
authors.lastname: Danielsson
authors.forename: A
authors.initials: A
authors.lastname: Ekernäs
authors.forename: A
authors.initials: A
authors.lastname: Gutierrez
authors.forename: U
authors.initials: U
authors.lastname: Petterson
authors.forename: T
authors.initials: T
authors.lastname: Lindholm
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000009:adverse effects; D002405:Catheterization, Central Venous; D003877:Dermatitis, Contact / Q000209:etiology*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011318:Prilocaine / Q000009:adverse effects / Q000627:therapeutic use*; D006435:Renal Dialysis
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine