Metabolic effects of a single administration of growth hormone on lipid and carbohydrate metabolism in normal-weight and obese subjects.
The effects on lipid metabolism of a single intramuscular dose of SR 29001 (0.15 U/kg body wt), a biosynthetic human growth hormone (hGH), were explored in a double-blind randomized crossover vs a placebo study of six normal-weight and six obese subjects (Quetelet Index greater than 120%). Circulating hGH concentrations reached means of 35 and 28 ng/mL in the normal-weight and obese subjects, respectively. Free fatty acids increased in both groups (p less than 0.05); increases in beta-hydroxybutyrate and acetoacetate concentrations were more moderate (NS). Plasma glucose increased significantly despite a significant increase in insulin (p less than 0.002). The lipolytic effect persisted after a standardized 950-kcal meal eaten 5 h after hGH administration. A delayed increase in somatomedin-C and decreases in blood urea and total cholesterol were also observed (p less than 0.05). Despite increased insulin secretion, biosynthetic hGH produced a significant increase of lipolysis in both groups, which was only partially suppressed by food.
Seng
G
G
Nutrition Department, University of Nancy I, France.
Galgoti
C
C
Louisy
P
P
Toussain
P
P
Drouin
P
P
Debry
G
G
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002241:Carbohydrates / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000097:blood*; D014508:Urea / Q000097:blood
D000090:Acetoacetates; D001786:Blood Glucose; D002241:Carbohydrates; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D008055:Lipids; C016635:acetoacetic acid; D007334:Insulin-Like Growth Factor I; D014508:Urea; D013006:Growth Hormone; D002784:Cholesterol; D020155:3-Hydroxybutyric Acid