[The status of the erythrocyte membranes and their functional properties in the postresuscitation period].
It was found that the deformation properties and peroxidation resistance of erythrocytes deteriorate in the postresuscitation period. On the basis of increase of the level of lipoperoxidation products and reduction of the level of alpha-tocopherol and nonprotein sulfhydryl groups, the authors conclude that lipid peroxidation in the erythrocyte membranes is activated after resuscitation. Disorders of molecular interactions are confirmed by the kinetics of nystatin fluorescent probe insertion and revealed increased cholesterol level in the erythrocyte membranes. It is suggested that the increase of the cholesterol level occurring as a protective response to the activation of lipid peroxidation transforms into a pathological reaction causing disorders of the deformation properties and peroxide resistance, which accelerates considerably the natural death of the erythrocytes after resuscitation.
Zueva
O M
OM
Lebedev
A S
AS
Korpachev
V G
VG
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003643:Death; D004907:Erythrocyte Deformability / Q000502:physiology; D004910:Erythrocyte Membrane / Q000502:physiology*; D015227:Lipid Peroxidation / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D012151:Resuscitation; D013050:Spectrometry, Fluorescence; D013997:Time Factors
D008055:Lipids
Sostoianie membran éritrotsitov i ikh funktsional'nye svoĭstva v postreanimatsionnom periode.