The prevalence of hyperlipidaemia and related clinical features in insulin-dependent diabetes mellitus.
The prevalence of hyperlipidaemia and related clinical features was examined in 205 individuals with insulin-dependent diabetes mellitus. Overall, 40 per cent (82) of the individuals had hyperlipidaemia. Whilst the prevalence of hypertriglyceridaemia and combined hyperlipidaemia was greater in patients with insulin-dependent diabetes mellitus than non-diabetics, this was not the case for hypercholesterolaemia. Hyperlipidaemia was present in older patients, and the daily insulin dose and levels of HbA1 were highest in those with combined hyperlipidaemia. In addition normolipidaemic subjects had the lowest levels of serum creatinine. Triglyceride levels were predicted (in order of importance) by insulin dose, age at diagnosis, HbA1 and body mass index, whilst cholesterol levels were predicted by the age at the time of study, body mass index, urinary protein excretion, and levels of fasting blood glucose and HbA1. Hyperlipidaemia is common in insulin-dependent diabetes mellitus, and may be particularly apparent in older patients and/or those with early renal dysfunction or poor glycaemic control.
Winocour
P H
PH
University of Manchester Faculty of Medicine, Department of Medicine Hope Hospital, Salford.
Durrington
P N
PN
Ishola
M
M
Hillier
V F
VF
Anderson
D C
DC
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology; D006949:Hyperlipidemias / Q000150:complications / Q000453:epidemiology*; D015228:Hypertriglyceridemia / Q000150:complications / Q000453:epidemiology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D015995:Prevalence
D001786:Blood Glucose; D008074:Lipoproteins