Thyroid function in sex-linked and autosomal dwarf chickens.
Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) elevated plasma thyroxine (T4) and triiodothyronine (T3) concentrations in a (euthyroid) control line of chickens and in an autosomal dwarf strain. These agents were ineffective in sex-linked dwarf (SLD) chickens. Similarly, while somatostatin (SRIF) lowered plasma T4 and T3 concentrations in autosomal dwarf (ADW) chickens and controls, it had no inhibitory effect in the SLD strain. These results suggest that an impairment in the hypothalamus-pituitary-thyroid axis is at least partly responsible for hypothyroidism in the SLD strain.
Lam
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SK
Department of Animal Sciences, Rutgers - State University, New Brunswick, New Jersey 08903.
Harvey
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Scanes
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D000818:Animals; D002645:Chickens / Q000235:genetics / Q000502:physiology*; D004392:Dwarfism / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D008297:Male; D012730:Sex Chromosomes; D013004:Somatostatin / Q000494:pharmacology / Q000502:physiology; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine