title: Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component.
abstract: The sequences of the A and B chains of the Scapharca inaequivalvis tetrameric hemoglobin (HbII) are reported. They are homologous to the corresponding chains of other Arcid hemoglobins. Moreover, a comparison of the present data with the sequence of the S. inaequivalvis dimeric hemoglobin (HbI), for which high-resolution X-ray data are available, allows the identification of the residues that direct the assembly of the two components and of those that may be involved in the interdimeric contacts.
authors.affiliation: Department of Biochemical Sciences, University La Sapienza, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Petruzzelli
authors.forename: A
authors.initials: A
authors.lastname: Boffi
authors.forename: D
authors.initials: D
authors.lastname: Barra
authors.forename: F
authors.initials: F
authors.lastname: Bossa
authors.forename: F
authors.initials: F
authors.lastname: Ascoli
authors.forename: E
authors.initials: E
authors.lastname: Chiancone
mesh_terms: D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006418:Heme; D006454:Hemoglobins / Q000235:genetics* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D008974:Mollusca / Q000502:physiology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D006454:Hemoglobins; D006418:Heme