[The use of klofelin for studying somatotropin secretion in children].
A stimulation clonidine test was performed in children for a study of STH secretion. The drug was injected at a dose of 0.15 m per 1 m2 of body surface. A total of 47 children were investigated. Of them 21 were healthy, with normal growth and 26 with constitutional retardation of growth (CRG). Maximum values of STH secretion were observed 60-90 min. after clonidine administration. Mean values of a STH secretion peak exceeded the initial ones greater than 8-fold in both groups without significant differences between them. Side-effects were insignificant and of transient nature. Thus clonidine is a sensitive, easy to use and safe stimulator of STH secretion. We revealed no difference in STH secretion between children with normal growth and those with CRG.
Antoshkina
A N
AN
Benikova
E A
EA
Derevianko
D I
DI
Epshteĭn
E V
EV
D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D003000:Clonidine / Q000009:adverse effects; D004341:Drug Evaluation; D005260:Female; D006130:Growth Disorders / Q000097:blood; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013268:Stimulation, Chemical; D013997:Time Factors
D013006:Growth Hormone; D003000:Clonidine
Primenenie klofelina dlia izucheniia sekretsii somatotropina u deteĭ.