[Expected risk of congenital toxoplasmosis in Florence and its province. Statistical research in 1984].
Research has been carried out to determine the prevalence of toxoplasma infection in 1176 women of fertile age in Florence and province for 1984 so as to calculate expected congenital foetal risk of toxoplasmosis. Prevalence proved to be 22% in women aged from 15 to 20 and 60% in the 41-45 group, with an average annual sero-conversion rate of 1.5%. As pregnancy lasts 9 months, this rate is cut by 1/4, namely it drops from 1.5% to 1.125%. Transmission of the infection from mother to foetus occurs in about 1/3 of cases. 9256 pregnancies were reported in Florence and province. The expectation was therefore 104 primary infections and 35 infected newborns of whom 11-12 clinically diagnosable at birth. The estimated rate of toxoplasmosis in pregnancy is therefore 11% for Florence and foetal infection is about 4%. Two-thirds of the newborns with toxoplasma infection are asymptomatic but, if left untreated, they may develop serious neurological and behavioural sequelae. It is therefore necessary to learn the immune state with respect to toxoplasma for all fertile women before pregnancy and study negative findings during gestation.
Calabri
G
G
Salvi
G
G
Nieri
R M
RM
Cocchi
P
P
Lanciotti
E
E
Comodo
N
N
De Mayo
E
E
Parri
F
F
Giambalvo
A
A
Silenzi
M
M
D000818:Animals; D000906:Antibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D007558:Italy; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D012307:Risk Factors; D014124:Toxoplasmosis, Animal / Q000635:transmission; D014125:Toxoplasmosis, Congenital / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D015047:Zoonoses
D000906:Antibodies
Rischio atteso di toxoplasmosi connatale in Firenze e provincia. Ricerca statistica nell'anno 1984.