title: Intestinal absorption of oxalate and calcium in patients with jejunoileal bypass.
abstract: Jejunoileal bypass (JIB) has been widely performed for treatment of excessive obesity. Formation of calcium oxalate stones is a common side effect. Since, under physiological conditions, the intestinal absorption of calcium and that of oxalate are interrelated, intestinal oxalate and calcium absorption were measured in the present study by isotope techniques in 19 JIB patients and 20 healthy controls. The JIB patients showed pronounced hyperoxaluria and markedly increased absorption of oxalate, with a urinary excretion of 14C-oxalate of 29 +/- 19% (controls 6.2 +/- 3.7%; p less than 0.001). There was a strong correlation between the intestinal absorption and urinary excretion of oxalate in the JIB patients (r = 0.72; p less than 0.001). Furthermore, their oxalate kinetics was altered, with continued urinary excretion of 14C-oxalate for up to 48 hours. The JIB patients also had reduced calcium absorption (36 +/- 9.1% vs. 47 +/- 9.0%; p less than 0.001) and patients with malabsorption of calcium and low urinary calcium had the highest intestinal absorption and urinary excretion of oxalate. It is concluded that hyperoxaluria in JIB patients is due to a significant extent to hyperabsorption of oxalate.
authors.affiliation: Department of Internal Medicine, University Hospital, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lindsjö
authors.forename: B G
authors.initials: BG
authors.lastname: Danielson
authors.forename: B
authors.initials: B
authors.lastname: Fellström
authors.forename: H
authors.initials: H
authors.lastname: Lithell
authors.forename: S
authors.initials: S
authors.lastname: Ljunghall
mesh_terms: D000328:Adult; D002118:Calcium / Q000493:pharmacokinetics*; D002129:Calcium Oxalate / Q000032:analysis; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000209:etiology*; D007408:Intestinal Absorption; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008297:Male; D010070:Oxalates / Q000493:pharmacokinetics*; D019815:Oxalic Acid; D014545:Urinary Calculi / Q000032:analysis / Q000209:etiology*
chemical_list: D010070:Oxalates; D002129:Calcium Oxalate; D019815:Oxalic Acid; D002118:Calcium