DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.
Townes
T M
TM
Department of Biochemistry, School of Medicine, University of Alabama, Birmingham 35294.
Ryan
T M
TM
Behringer
R R
RR
Palmiter
R D
RD
Brinster
R L
RL
D000818:Animals; D002872:Chromosome Deletion; D015672:Erythroid Precursor Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D006451:Hemoglobin, Sickle / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D011994:Recombinant Proteins / Q000096:biosynthesis; D012045:Regulatory Sequences, Nucleic Acid; D013789:Thalassemia / Q000235:genetics; D014158:Transcription, Genetic
D006451:Hemoglobin, Sickle; D011994:Recombinant Proteins; D005914:Globins