Efficient formation of cytosine arabinoside-5'-triphosphate in leukemic blasts of human T-cell acute lymphoblastic leukemia.
The potential usefulness of cytosine arabinoside (ara-C) in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) was studied by measuring the influx of ara-C into the lymphoblasts and the conversion of ara-C to its triphosphate form (ara-CTP) in lymphoblasts from the bone marrow of eighteen patients of T-ALL. Intracellular accumulation of ara-CTP was 3.5 times greater in T-cell lymphoblasts than in non-T or AML blasts. The increased formation of ara-CTP in T-ALL cell may be correlated with the good clinical response of T-ALL patients to the treatment with ara-C in combination with mitoxantrone.
Tanaka
M
M
Hematological Disease Center, Nagoya National Hospital, Naka-ku, Japan.
Yoshida
S
S
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001085:Arabinofuranosylcytosine Triphosphate / Q000378:metabolism*; D001088:Arabinonucleotides / Q000378:metabolism*; D003561:Cytarabine / Q000627:therapeutic use*; D006801:Humans; D007399:Interphase; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D008942:Mitoxantrone / Q000627:therapeutic use
D015703:Antigens, CD; D001088:Arabinonucleotides; D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D008942:Mitoxantrone