Immunopathology of nasal polyps: an immunohistochemical approach.
We studied the mast cells and the T-lymphocyte subpopulations of four patients' nasal polyps using immunohistochemical procedures. The data showed that MC displayed IL2-receptor and that they were very often closely related to CD4+ and MHC class II-positive T-lymphocytes. CD8-positive T-cells represented only 10% to 15% of the whole lymphoid population and were not localized near mast cells. These findings suggest a possible role of cell-mediated immune reactions in the pathogenesis of nasal polyps.
Larocca
L M
LM
Department of Pathology, Catholic University of the Sacred Heart, Rome, Italy.
Maggiano
N
N
Capelli
A
A
Bevilacqua
P
P
Ruscito
P
P
Maurizi
M
M
Bellioni
P
P
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D009298:Nasal Polyps / Q000209:etiology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000949:Histocompatibility Antigens Class II; D015375:Receptors, Interleukin-2