title: Dynorphin A(1-8) immunoreactive cell bodies, dendrites and terminals are postsynaptic to calcitonin gene-related peptide primary afferent terminals in the monkey dorsal horn.
abstract: In the present study, Dynorphin A(1-8) (DYN)-immunoreactive cell bodies, dendrites and terminals are observed postsynaptic to calcitonin gene-related peptide (CGRP)-immunoreactive terminals in laminae I and II. With the demonstration of axosomatic, axodendritic as well as axoaxonic interactions, we hypothesize that CGRP-containing primary afferent terminals can effect processing at the level of the cell body (possibly influencing the manufacture of DYN and/or the firing rate of DYN-containing cells) and also modulate the output of DYN terminals in laminae I and II of the monkey dorsal horn. These structural relationships may play an important role in the processing of noxious input at the spinal cord level.
authors.affiliation: Department of Anatomy and Neuroscience, University of Texas Medical Branch, Galveston 77550.
authors.forename: S M
authors.initials: SM
authors.lastname: Carlton
authors.forename: E S
authors.initials: ES
authors.lastname: Hayes
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D004399:Dynorphins / Q000378:metabolism*; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D008251:Macaca / Q000378:metabolism*; D008252:Macaca fascicularis / Q000033:anatomy & histology / Q000378:metabolism*; D009411:Nerve Endings / Q000378:metabolism / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000378:metabolism* / Q000648:ultrastructure; D010446:Peptide Fragments / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism* / Q000648:ultrastructure; D013266:Stilbamidines
chemical_list: C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D010446:Peptide Fragments; D013266:Stilbamidines; D004399:Dynorphins; C026770:dynorphin (1-8); D015740:Calcitonin Gene-Related Peptide