[1,4]Benzoxazine-2,3-diones as antiallergic agents.
The synthesis of a series of [1,4]benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described. These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat. Some of these compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.
Loev
B
B
Jones
H
H
Brown
R E
RE
Huang
F C
FC
Khandwala
A
A
Leibowitz
M J
MJ
Sonnino-Goldman
P
P
D000818:Animals; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000188:drug therapy*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D010078:Oxazines / Q000138:chemical synthesis* / Q000627:therapeutic use; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D010078:Oxazines