[The effect of folic acid and methotrexate on the activity of the glucuronyl- and glutathione-conjugating systems of the liver in rats].
Administration to intact male rats of folic acid (25 mg/kg intragastrically for 14 days) was shown to increase and that of methotrexate (0.5 mg/kg subcutaneously) for 14 days) to decrease the activities of the rat liver uridine-diphosphate-glucuronosyl- and glutathione-S-transferases.
Legon'kova
L F
LF
Lukienko
P I
PI
Bushma
M I
MI
D000818:Animals; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D005965:Glucuronates / Q000378:metabolism*; D020723:Glucuronic Acid; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D013997:Time Factors
D005965:Glucuronates; D020723:Glucuronic Acid; D005492:Folic Acid; D005978:Glutathione; D008727:Methotrexate
Vliianie folievoĭ kisloty i metotreksata na aktivnost' gliukuronil- i glutationkon''giruiushchikh sistem pecheni krys.