title: Lactobionic acid as an iron chelator: a rationale for its effectiveness as an organ preservant.
abstract: Lactobionic acid, a major constituent of a solution used to preserve organs prior to transplantation, can chelate ferric iron. This is evident by its ability to solubilize iron as well as changes that occur in the UV-VIS spectra of iron in its presence. Relative to iron (III) chelated to EDTA, the lactobionic acid-iron (III) complex is less able to participate in the Fenton reaction as measured by formaldehyde generation from DMSO and bleaching of p-N,N-dimethylnitrosoaniline. Similar effects are seen with citrate and ATP, two substances which also appear to be able to ameliorate ischemia/reperfusion injury. These findings present a rationale for the effectiveness of lactobionic acid as an organ preservant.
authors.affiliation: Department of Medicine, University of Pittsburgh, PA 15261.
authors.forename: Y
authors.initials: Y
authors.lastname: Isaacson
authors.forename: O
authors.initials: O
authors.lastname: Salem
authors.forename: R E
authors.initials: RE
authors.lastname: Shepherd
authors.forename: D H
authors.initials: DH
authors.lastname: Van Thiel
mesh_terms: D002384:Catalysis; D004121:Dimethyl Sulfoxide / Q000378:metabolism; D004187:Disaccharides / Q000494:pharmacology*; D005557:Formaldehyde / Q000378:metabolism; D005609:Free Radicals; D007502:Iron Chelating Agents; D008968:Molecular Conformation; D009926:Organ Preservation; D015427:Reperfusion Injury / Q000517:prevention & control; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004187:Disaccharides; D005609:Free Radicals; D007502:Iron Chelating Agents; D005557:Formaldehyde; C005608:lactobionic acid; D004121:Dimethyl Sulfoxide