Duodenal acidification and jejunal hyperosmolality inhibit pentagastrin-stimulated acid secretion in chronic gastric fistula rats.
In chronic gastric fistula (GF) rats, HCl and a hyperosmolal solution of polyethylene glycol (PEG) in the upper intestine inhibit pentagastrin-stimulated gastric acid secretion by different mechanisms, but their anatomic sites have not yet been established. In the present study GF rats were provided with Thiry-Vella loops of the duodenum and the bile and pancreatic ducts transplanted to the proximal jejunum, or with Thiry-Vella loops of the proximal jejunum. In the latter rats the duodenum was anastomosed as a blind loop to the jejunum to prevent any gastric juice from entering the duodenum. Duodenal loop perfusion with 0.20 M HCl inhibited the acid response to pentagastrin by 62%, but perfusion with 1200 mOsmol x kg-1 of PEG solution did not alter the response. In contrast, acidification of the proximal jejunal loop did not alter but hyperosmolality inhibited the response by 41%. The study shows that the mechanism for inhibition by intestinal acidification is confined to the duodenum and that for inhibition by hyperosmolality is located in the proximal jejunum--but whether only to the proximal part is unknown.
Wallin
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C
Dept. of Surgery, Karolinska Hospital, Stockholm, Sweden.
Emås
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S
D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005747:Gastric Fistula / Q000503:physiopathology*; D006851:Hydrochloric Acid / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D010418:Pentagastrin / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011092:Polyethylene Glycols; D010418:Pentagastrin; D006851:Hydrochloric Acid