Deltamethrin causes changes in protein phosphorylation activities associated with post-depolarization events in the synaptosomes from the optic lobe of squid, Loligo pealei.
1. Deltamethrin causes a significant change in protein phosphorylation activities which follow depolarization. 2. The most significant change caused by deltamethrin was the prolonged elevation of the level of phosphorylation on a number of key synaptic proteins beyond the normal time of their recovery to the dephosphorylated state. 3. The best marker proteins reacting to deltamethrin in this manner were calcium-calmodulin dependent protein kinase and synapsin I.
Matsumura
F
F
Department of Environmental Toxicology, University of California, Davis 95616.
Clark
J M
JM
Matsumura
F M
FM
D000818:Animals; D001345:Autoradiography; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D049832:Decapodiformes / Q000187:drug effects* / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D007306:Insecticides / Q000633:toxicity*; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000187:drug effects* / Q000378:metabolism; D009570:Nitriles; D009899:Optic Lobe, Nonmammalian / Q000187:drug effects / Q000378:metabolism; D010750:Phosphoproteins / Q000032:analysis; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011722:Pyrethrins / Q000633:toxicity*; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D007306:Insecticides; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009570:Nitriles; D010750:Phosphoproteins; D011722:Pyrethrins; C017180:decamethrin; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases