Carbohydrate antigenic determinant (CA 19-9) and other tumor markers in gastrointestinal malignancies.
The serum carbohydrate antigenic determinant (CA 19-9) was assayed in patients with various diseases, and it provides excellent sensitivity for adenocarcinoma of the pancreas (25/27, 93%), while only 4% (2/54) of the patients with benign diseases and none of the 40 healthy subjects showed elevated CA 19-9 concentrations over 37 units/ml as upper normal value. Increased serum carcinoembryonic antigen (CEA) levels over 2.5 ng/ml were observed in patients with pancreatic cancer (18/22, 82%), compared to 22% (12/54) of the patients with benign diseases and 10% (4/40) of the healthy subjects. 12 of the 19, 6 of the 19 and none of the 22 patients with pancreatic cancer exhibited high serum ferritin, beta 2-microglobulin, or alpha-fetoprotein levels, respectively. A significant difference in CA 19-9 was found between patients with pancreatic cancer and gastric cancer, other gastrointestinal (GI) malignancies, other non-GI malignancies, benign digestive diseases or normal populations.
Yoshikawa
T
T
Nishida
K
K
Tanigawa
M
M
Fukumoto
K
K
Kondo
M
M
D000230:Adenocarcinoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D000939:Epitopes / Q000032:analysis*; D005293:Ferritins; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis; D001613:beta 2-Microglobulin
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D000509:alpha-Fetoproteins; D001613:beta 2-Microglobulin; D005293:Ferritins