Effect of chronic administration of dexfenfluramine on stress- and palatability-induced food intake in rats.
Dexfenfluramine, administered chronically either SC via osmotic minipump (3 mg/kg/day) or as daily IP injections (1.5 mg/kg) to rats, suppressed tail pinch-induced eating for up to 14 days. The minipump regimen also caused a reduction of intake of a palatable "dessert" for up to 9 days in heavy, adult rats, but was only transiently effective in young, rapidly growing rats. Nonetheless, the regimen produced decreased weight gain and insensitivity to a subsequent acute test dose of the agent. These results illustrate the sustained anorectic efficacy of dexfenfluramine in paradigms that do not involve restriction of diet, and these may be animal models of snacking or binging. The data also corroborate previous suggestions that the agent is more effective in older or more obese populations.
Souquet
A M
AM
Department of Psychology, University of Florida, Gainesville 32611.
Rowland
N E
NE
D000818:Animals; D004361:Drug Tolerance / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects*; D015918:Infusion Pumps, Implantable; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D005277:Fenfluramine