Vascular dilatory action of Artemisia capillaris bud extracts and their active constituent.
In perfusion experiments, the acetone extract of Artemisia capillaris buds significantly inhibited the response to norepinephrine of helical strips of rabbit thoracic aorta. The acetone extract was fractionated by column chromatography to identify the active constituent. Kinetic experiments using rabbit thoracic aorta showed that 6,7-dimethoxycoumarin (scoparone) has a marked inhibitory effect on the contractions induced by norepinephrine, 5-hydroxytryptamine, histamine and angiotensin II. Like nitroglycerin, scoparone appeared to be a competitive antagonist of norepinephrine.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Kobayashi
G
G
Matsuda
H
H
Katayama
T
T
Fujimura
H
H
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000502:physiology; D010946:Plants, Medicinal; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D003374:Coumarins; D014665:Vasodilator Agents; C018145:scoparone; D009638:Norepinephrine