Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery.
A close spatial relationship between serotonin-containing mast cells and substance P-containing nerves was shown by immunohistochemistry using a combination of antisera specific for serotonin and substance P. This supports earlier morphological results suggesting an innervation of mast cells and pharmacological studies which postulate an influence of substance P on the release of histamine from mast cells.
Skofitsch
G
G
Savitt
J M
JM
Jacobowitz
D M
DM
D000818:Animals; D003964:Diaphragm / Q000033:anatomy & histology*; D006651:Histocytochemistry; D007106:Immune Sera; D008297:Male; D008407:Mast Cells / Q000032:analysis / Q000502:physiology*; D008643:Mesentery / Q000033:anatomy & histology*; D009412:Nerve Fibers / Q000032:analysis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013194:Staining and Labeling; D013373:Substance P / Q000032:analysis
D007106:Immune Sera; D012701:Serotonin; D013373:Substance P