title: Management of early endometrial carcinoma.
abstract: Management of early endometrial carcinoma is controversial in regard to timing and indication of adjunctive radiation therapy. Two hundred eighty patients with stage I carcinoma of the endometrium are analyzed: 135 patients were treated with surgery only and 61 patients underwent preoperative and 83 patients postoperative radiation therapy. The overall survival was 94%. Recurrence rates in all three treatment arms were equal. Tumor grade was found to change from the diagnostic D&C specimen to the definite surgical specimen in 31% of all cases and in 50% of all grade 3 lesions. As only 39% of all patients required postoperative radiation therapy with equal survival, a primary surgical approach spares the majority of patient unnecessary treatment and preserves prognostically important histology.
authors.affiliation: Department of Radiation Oncology, University of Alabama, Birmingham 35233.
authors.forename: L J
authors.initials: LJ
authors.lastname: Sant Cassia
authors.forename: B
authors.initials: B
authors.lastname: Weppelmann
authors.forename: H
authors.initials: H
authors.lastname: Shingleton
authors.forename: S J
authors.initials: SJ
authors.lastname: Soong
authors.forename: K
authors.initials: K
authors.lastname: Hatch
authors.forename: M M
authors.initials: MM
authors.lastname: Salter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D014594:Uterine Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*