title: Efficacy and safety of the combination therapy Pilogel/beta-blocker: interim results.
abstract: The interim results of a multicentered clinical trial with the combination therapy therapy Pilogel/topical beta-blocker (twice daily) in patients with primary open angle glaucoma or ocular hypertension are discussed. Six patients were treated with Pilogel and a topical beta-blocker for one month. Four out of six patients responded well to the combination therapy. Most patients experienced some difficulty in applying the gel and their eyelids stuck together on awakening. In two patients a superficial punctate keratitis was observed. We found an average decrease in intra-ocular pressure (IOP) of 22.5% 22.5 hours after Pilogel administration, but there was some tendency towards higher evening values compared to morning values. In view of the appearance of a corneal haze as described by Johnson et al. during long-term treatment, longer follow-up is necessary.
authors.affiliation: Department of Ophthalmology, Diakonessenhuis Utrecht, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Maas
authors.forename: F E
authors.initials: FE
authors.lastname: Ros
authors.forename: L J
authors.initials: LJ
authors.lastname: De Heer
authors.forename: R J
authors.initials: RJ
authors.lastname: De Keizer
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D015784:Betaxolol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D014290:Metipranolol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009798:Ocular Hypertension / Q000188:drug therapy*; D010862:Pilocarpine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011680:Pupil / Q000187:drug effects; D012029:Refraction, Ocular; D013999:Timolol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D005782:Gels; D010862:Pilocarpine; D013999:Timolol; D015784:Betaxolol; D014290:Metipranolol