title: Atrial natriuretic peptide (ANP) is removed by peritoneal dialysis in humans.
abstract: Atrial natriuretic peptide (ANP) is a hormone liberated from the heart during atrial stretch (volume overload). In order to determine if ANP levels are altered in patients on continuous ambulatory peritoneal dialysis (CAPD) or affected by the dialysis procedure itself, we measured plasma ANP in patients before and after peritoneal infusion of two liters of 1.5% Dianeal dialysate and in dialysate subsequently drained from these patients. Plasma ANP is elevated in CAPD patients, but is not affected by infusion of dialysate. ANP is cleared from plasma by peritoneal dialysis.
authors.affiliation: Department of Medicine, Medical College of Georgia, Augusta 30912-3140.
authors.forename: M E
authors.initials: ME
authors.lastname: Fincher
authors.forename: H T
authors.initials: HT
authors.lastname: Campbell
authors.forename: A H
authors.initials: AH
authors.lastname: Sklar
authors.forename: R J
authors.initials: RJ
authors.lastname: Caruana
authors.forename: B O
authors.initials: BO
authors.lastname: Lightfoot
authors.forename: P L
authors.initials: PL
authors.lastname: Cheek
authors.forename: K L
authors.initials: KL
authors.lastname: Smith
authors.forename: C P
authors.initials: CP
authors.lastname: Hess
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000097:blood*; D015314:Dialysis Solutions / Q000032:analysis; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis
chemical_list: D015314:Dialysis Solutions; D009320:Atrial Natriuretic Factor