title: Microbial conversion of anthracyclinones to carminomycins by a blocked mutant of Actinomadura roseoviolacea.
abstract: New anthracycline antibiotics, 1-hydroxy-11-deoxycarminomycin II and 11-deoxycarminomycin II were produced by a blocked mutant MuW1 of Actinomadura roseoviolacea from epsilon-pyrromycinone and aklavinone, respectively. We found that the enzyme catalyzing hydroxylation at the C-11 position was not lost but was down regulated in the strain MuW1.
authors.affiliation: Institute of Applied Microbiology, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Imamura
authors.forename: H
authors.initials: H
authors.lastname: Seto
authors.forename: N
authors.initials: N
authors.lastname: Otake
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D002360:Carubicin / Q000096:biosynthesis*; D002855:Chromatography, Thin Layer; D003630:Daunorubicin / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009154:Mutation; D009618:Nocardiaceae / Q000235:genetics / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D002360:Carubicin; D003630:Daunorubicin