title: Effect of ganglionic stimulating and blocking agents on the fast components of colonic myoelectrical activity in the rat.
abstract: The presence of two types of fast myoelectrical activities, medium fast activity and fast activity, has been demonstrated previously in the electromyogram of colon in normal children and in the rat by the authors. An absence of medium fast activity in Hirschsprung's disease and in experimental aganglionosis of colon in the rat has also been described. In the present study the fast components of colonic myoelectrical activity were analysed during the procedures affecting ganglionic transmission. It was observed that ganglionic stimulants, such as balloon inflation, and intra-arterial injections of acetylcholine and small amounts of nicotine, increased the spike activity and the frequency of medium fast activity without affecting fast activity. The intra-arterial injections of ganglionic blocking agents, such as nicotine in large amounts and pentolinium tartrate, completely abolished the medium fast activity. These observations suggest that the ganglionic activity is responsible for the genesis of medium fast activity and that the absence of cholinergic ganglionic transmission is the most important single factor for the reported altered electromyogram pattern in aganglionosis.
authors.affiliation: Department of Physiology and Paediatric Surgery, Medical College, Rohtak, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Chandran
authors.forename: R K
authors.initials: RK
authors.lastname: Marya
authors.forename: L K
authors.initials: LK
authors.lastname: Sharma
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000294:innervation; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D005730:Ganglionic Blockers / Q000494:pharmacology*; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation*; D009538:Nicotine / Q000494:pharmacology; D010425:Pentolinium Tartrate / Q000494:pharmacology; D051381:Rats
chemical_list: D005730:Ganglionic Blockers; D005731:Ganglionic Stimulants; D009538:Nicotine; D010425:Pentolinium Tartrate; D000109:Acetylcholine