title: The prevention of infection with Staphylococcus aureus in continuous ambulatory peritoneal dialysis.
abstract: We describe the control of wound infection with Staphylococcus aureus in patients undergoing continuous ambulatory peritoneal dialysis at St. Thomas' Hospital. Forty-nine percent of 61 catheters inserted in 1985 and 1986 became infected, and the majority of these infections were acquired in hospital. Infection was impossible to eradicate and was frequently associated with the subsequent development of S. aureus peritonitis, which was the most important cause of catheter loss. Strict adherence to aseptic techniques for catheter insertion and care, combined with eradication of S. aureus carriage, reduced the infection rate to 12% for the 50 catheters inserted in 1987, abolished hospital-acquired infection and reduced the S. aureus peritonitis rate tenfold, without the use of prophylactic antibiotics. S. aureus infection is a serious but avoidable complication of continuous ambulatory peritoneal dialysis.
authors.affiliation: Department of Medical Microbiology, St. Thomas' Hospital, London, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Ludlam
authors.forename: A E
authors.initials: AE
authors.lastname: Young
authors.forename: A J
authors.initials: AJ
authors.lastname: Berry
authors.forename: I
authors.initials: I
authors.lastname: Phillips
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001207:Asepsis / Q000379:methods; D002408:Catheters, Indwelling / Q000009:adverse effects; D002710:Chlorhexidine / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009779:Occlusive Dressings; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000209:etiology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use; D014946:Wound Infection / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local; D005436:Floxacillin; D014640:Vancomycin; D002710:Chlorhexidine