Testicular steroid sulfatase in a cryptorchid rat strain.
Steroid sulfatase (STS) activity was studied in scrotal and abdominal testes from genetically unilateral cryptorchid rats. Specific STS activity was significantly increased in microsomes from abdominal and scrotal testes of the cryptorchid animals as compared to that of control ones. When expressed per gonad, STS activity was only enhanced in the scrotal testis. No difference in the enzyme affinity was observed between descended and undescended testes. Testosterone content was markedly reduced in the abdominal testes. Normal plasma testosterone levels together with elevated LH levels were measured in the cryptorchid rats. The existence of differences in STS expression between descended and undescended testes gives additional support for this enzymatic activity being implicated in testicular function.
Mouhadjer
N
N
INSERM U. 166, Groupe de Recherches sur l'Endocrinologie de la Reproduction, Maternité Baudelocque, Paris, France.
Pointis
G
G
Malassine
A
A
Bedin
M
M
D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism*; D003456:Cryptorchidism / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D051381:Rats; D011922:Rats, Mutant Strains; D013091:Spermatogenesis; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism*; D013737:Testis / Q000201:enzymology* / Q000473:pathology; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D013739:Testosterone; D013429:Sulfatases; D001192:Arylsulfatases; D043266:Steryl-Sulfatase