[Activity of lysosomal enzymes in drug-induced lesions of the liver].
In the experiments on Wistar rats we showed that administration of ulcerogenic drugs (cinchophen, acetylsalicylic acid, butadione, indomethacin etc.) produced the alterations of free activity of lysosomal enzymes in the homogenates of ulcerated stomach, presumably the significant elevation of the activity of cathepsins (more often cathepsin with optimum of activity at pH 5.5) and the significant reduction of free activity of acid nucleases (more often of DNA-ase). The alterations of free activity of lysosomal enzymes were as in cases with gastric ulcerations as in cases with unaffected stomach.
Ostapchuk
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NA
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D002251:Carbon Tetrachloride; D002403:Cathepsins / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D010653:Phenylbutazone; D011804:Quinolines; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D011804:Quinolines; D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000135:Acid Phosphatase; D002403:Cathepsins; D010653:Phenylbutazone
Aktivnost' lizosomal'nykh fermentov pri lekarstvennykh porazheniiakh pecheni.