title: Multiple endocrine neoplasia type II: clinical, biological and epidemiological features. French Medullary Study Group.
abstract: Medullary thyroid carcinoma (MTC) is a particularly interesting model of gene expression in cancer. As a matter of fact, it is remarkable from many points of view: it occurs in two forms: (1) MTC only or part of a multiple endocrine neoplasia II (MEN II), and (2) it is sporadic or inherited and benefits from a specific and sensible marker, calcitonin; the gene responsible for the hereditary form is localized on chromosome 10. Taking into account clinical, biological, genealogical and epidemiological features of the disease as supporting one another, a French collective study has been initiated; preliminary analysis of data allows to conclude on the value of such national collaboration for early diagnosis, prognosis and estimation of the incidence of the disease.
authors.affiliation: INSERM, U. 113, CHU St-Antoine, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Calmettes
mesh_terms: D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D005602:France; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology