Thermal salivation in rats, anesthetized with barbiturates, chloralose, urethane and ketamine.
1. The relationship between thermal salivation (TS) and thermoregulation was studied in anesthetized rats. 2. Of the 6 anesthetics used, ketamine-anesthetized rats secreted the largest amount of saliva. Salivation, however, was thermal and not induced by ketamine itself. 3. Ketamine-anesthetized rats readily secreted saliva at core temperatures less than 40 degrees C but TS was remarkably enhanced by hyperthermia of 40-42.5 degrees C. 4. The equilibrium phase in the triphasic heat response of core temperature was a consequence of equilibrium between heat gain and heat loss by salivation.
Furuyama
F
F
Department of Physiology, Nagoya City University Medical School, Japan.
Ishida
Y
Y
Furuyama
M
M
Hashitani
T
T
Isobe
Y
Y
Sato
H
H
Ohara
K
K
Nishino
H
H
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects*; D002698:Chloralose / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012472:Salivation / Q000187:drug effects*; D014520:Urethane / Q000494:pharmacology
D000777:Anesthetics; D001463:Barbiturates; D002698:Chloralose; D014520:Urethane; D007649:Ketamine