Treatment of neuroleptic-induced akathisia with propranolol: a controlled replication study.
Twelve DSM-IIIR diagnosed schizophrenics, with neuroleptic-induced akathisia (NIA), were treated with either propranolol or matched placebo for two days, followed by a treatment crossover phase for five more days. Raters and patients were "blind" to treatment. This study shows that 120 mg of propranolol a day is more effective than placebo in reducing akathisia, and that propranolol's antiakathisic effect may require several days of treatment.
Kramer
M S
MS
Coatesville Veterans Administration Medical Center, Pa.
Gorkin
R
R
DiJohnson
C
C
D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001590:Benztropine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D009460:Neurologic Examination; D011433:Propranolol / Q000008:administration & dosage*; D011595:Psychomotor Agitation / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D001590:Benztropine; D011433:Propranolol