Attenuation of the reflex pressor response to muscular contraction by a substance P antagonist.
In chloralose-anesthetized cats, we found that D-Pro2-D-Phe7-D-Trp9-substance P (40-100 micrograms), injected intrathecally, reduced the reflex pressor response to static muscular contraction by more than half.
Kaufman
M P
MP
Kozlowski
G P
GP
Rybicki
K J
KJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D007278:Injections, Spinal; D009119:Muscle Contraction; D005082:Physical Exertion; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*
D013373:Substance P; C041817:substance P, Pro(2)-Phe(7)-Trp(9)-