[The mechanism of action of pachycarpine on the nicotinic cholinoreceptors of sympathetic ganglion neurons in the rat].
The mechanism of the pachycarpine action was studied in isolated superior cervical ganglion of rat using the patch-clamp method in the whole-cell recording mode. Action of the pachycarpine is not potential-dependent in the membrane potential range from +30 to -50 mV, the blockade increases during hyperpolarization of the membrane (-50-90 mV). Changes in the "dose-effect" dependence show that the blocking of nicotinic acetylcholine receptors is competitive both within the potential-dependent interval and within the potential-independent one.
Purnyn'
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Voĭtenko
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SV
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000502:physiology; D013034:Sparteine / Q000494:pharmacology*; D013237:Stereoisomerism
D011978:Receptors, Nicotinic; D013034:Sparteine; D000109:Acetylcholine
Mekhanizm deĭstviia pakhikarpina na nikotinovye kholinoretseptory neĭronov simpaticheskogo gangliia krysy.