Complex segregation analysis for a three-allele locus: experience from an analysis of acid phosphatase activity.
A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.
Iselius
L
L
Department of Community Medicine, Southampton General Hospital, England.
Evans
D A
DA
Eze
L C
LC
Tweedie
M C
MC
Bullen
M F
MF
Wren
P J
PJ
D000135:Acid Phosphatase / Q000235:genetics*; D000483:Alleles; D002874:Chromosome Mapping; D004739:England; D004912:Erythrocytes / Q000201:enzymology; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic
D000135:Acid Phosphatase