[In vitro detection of ovalbumin-specific IgA producing cells from lymphocytes of patients with hen-egg allergy].
We studied antigen-specific IgA production from the peripheral lymphocytes of children with hen-egg allergy by using the method of indirect plaque forming cell (PFC) assay. The number of OVA-specific IgA-PFC generated from the patient lymphocytes was low (6 +/- 3/7 X 10(4) non T cells) in comparison with age-matched normal children (112 +/- 18/7 X 10(4) non T cells). The numbers of OVA-specific IgG-PFC and IgM-PFC generated from the patient lymphocytes were not so different from those of the age-matched normal children. This indicates that the activity of OVA-specific IgA-antibody production was reduced in patients with hen-egg allergy.
Yamaguchi
K
K
Noma
T
T
Baba
M
M
Yata
J
J
D002675:Child, Preschool; D004531:Eggs; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology*
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D010047:Ovalbumin