[Evaluation of obzidan efficacy in patients with unstable stenocardia].
Altogether 75 patients (males aged 31 to 67 years) with unstable angina pectoris were subjected to transcutaneous pacing to measure the coronary reserve level before and after administration of obsidan (propranolol) in a dose of 40 mg. The area and depth of ischemia were found to be noticeably decreased, which was appraised according to 35 precordial leads on the ECG regardless of the unchanged "double product". It is concluded that not only the reduction of the heart rate and afterload but also their effect on the functional factors of angina pectoris are implicated in the mechanism of the anti-ischemic action of the beta-blockers.
Gvatua
N A
NA
SHumakov
V A
VA
Tashchuk
V K
VK
Malinovskaia
I E
IE
Pliska
A I
AI
D000328:Adult; D000368:Aged; D000787:Angina Pectoris; D000789:Angina, Unstable / Q000175:diagnosis / Q000188:drug therapy*; D002304:Cardiac Pacing, Artificial / Q000379:methods; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy; D004341:Drug Evaluation; D004452:Echocardiography; D004562:Electrocardiography / Q000379:methods; D004630:Emergencies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*
D011433:Propranolol
Otsenka éffektivnosti obzidana u bol'nykh nestabil'noĭ stenokardieĭ.