Intraoperative radiation therapy-induced sarcomas in dogs.
In a canine model the tolerance of normal and surgically manipulated tissue to intraoperative radiotherapy (IORT) was investigated to provide guidelines for the clinical use of IORT in human cancer patients. A dose of 20 Gy IORT, with or without external beam radiotherapy, was generally well tolerated without significant increased treatment morbidity. Higher doses of IORT (over 30 Gy) have produced radiation-induced sarcomas in some animals followed over a long period. Therefore IORT should be used only in human cancer patients in well controlled studies, in which complications are well documented, and the possibility of radiation-induced malignancies in long-term survival should be considered.
Hoekstra
H J
HJ
Department of Surgical Oncology, Groningen University Hospital, The Netherlands.
Sindelar
W F
WF
Kinsella
T J
TJ
Mehta
D M
DM
D000818:Animals; D004285:Dogs; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology; D006394:Hemangiosarcoma / Q000209:etiology; D007432:Intraoperative Period; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000209:etiology