Bioavailability of intranasal metoclopramide.
After intranasal administration of metoclopramide, (5 mg in 0.5 ml sterile water) the maximum plasma concentration of 13.5 +/- 7.3 (mean +/- s.d.) ng ml-1 was achieved. Absolute bioavailability was 50.5 +/- 29.5%, 110 +/- 41 min later. We conclude that the intranasal route does not allow rapid absorption of the drug and is not associated with greater bioavailability than the oral route.
Ward
M J
MJ
Department of Clinical Pharmacology, University of Wales College of Medicine, Liandough Hospital, South Glamorgan.
Buss
D C
DC
Ellershaw
J
J
Nash
A
A
Routledge
P A
PA
D000042:Absorption; D000281:Administration, Intranasal; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000493:pharmacokinetics*
D008787:Metoclopramide