Spermidine level as a parameter in the treatment of patients with malignant melanoma.
Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay. Baseline values were normal in 17 courses, a doubling of plasma levels following chemotherapy occurred in 13 courses. There was no relation between the occurrence of a tumor response and an increase in spermidine levels nor between hematological toxicity or digestive tract toxicity and spermidine levels.
Smit
J M
JM
Jurjens
H
H
Bouman
J
J
Bijzet
J
J
Sleijfer
D T
DT
Woldring
M G
MG
Mulder
N H
NH
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D013095:Spermidine / Q000097:blood*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014751:Vindesine
D001761:Bleomycin; D003609:Dactinomycin; D014747:Vinblastine; D003606:Dacarbazine; D014751:Vindesine; D013095:Spermidine