Lys- and Tyr-arylamidase activities in serum and brain during the estrous cycle of the rat.
Peptidase enzymes are involved in neuropeptide processing or degradation. In order to analyse a possible functional participation of these enzymes, arylamidase activity of several rat brain regions and serum was assayed in the soluble fraction during the estrous cycle using L-Lys- and L-Tyr-beta-naphthylamide as substrates. Significant differences were present in the hypothalamus, the pituitary and serum when both substrates were used. However, there were no differences in cortical areas. These results suggest a role for arylamidase activity in the hormonal changes that happen during the estrous cycle of the rat.
de Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Spain.
Casis
L
L
Irazusta
J
J
Echevarría
E
E
Arechaga
G
G
Ramírez
M
M
D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004971:Estrus / Q000502:physiology*; D005260:Female; D007031:Hypothalamus / Q000201:enzymology; D010902:Pituitary Gland / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D000626:Aminopeptidases