[The value of determining anti-gliadin antibodies as well as carotene and xylose blood levels in various phases of celiac disease].
The usefulness of measuring xylosaemia, carotenaemia and the antigliadin antibodies in the diagnosis and monitoring of coeliac diseases has been examined, 89 children, 57 with aspecific chronic diarrhoea and 32 with coeliachia were examined. The xylose proved less sensitive (80%) and less specific (84.2%) than carotenaemia (respectively: sensitivity 86.6% and specificity 87.7%). Nevertheless, considering the by no means negligible percentage of false positives and false negatives encountered with both techniques, it should be reiterated that these tests have a purely orientative value, whereas measurement of serum AGA may be considered a highly reliable investigation for selective children to be submitted to biopsy, considering the high sensitivity (AGA IgG 100%; AGA IgA 90.9%) and specificity (AGA IgG 85%; AGA IgA 100%) observed in the present series.
Caiulo
V A
VA
Lupetti
L
L
Ughi
C
C
Cortigiani
L
L
Ceccarelli
M
M
D000906:Antibodies / Q000276:immunology; D002338:Carotenoids / Q000097:blood*; D002446:Celiac Disease / Q000097:blood / Q000276:immunology*; D002648:Child; D005903:Gliadin / Q000097:blood / Q000276:immunology*; D006801:Humans; D010940:Plant Proteins / Q000276:immunology*; D014994:Xylose / Q000097:blood*
D000906:Antibodies; D010940:Plant Proteins; D002338:Carotenoids; D005903:Gliadin; D014994:Xylose
Utilità della determinazione degli anticorpi anti-gliadina, della carotenemia e della xilosemia nelle varie fasi della malattia celiaca.