[Comparison of carbohydrate antigens--sialylated Lewisx and sialylated SSEA-1 in the sera from patients with primary lung cancer].
Serum levels of sialylated Lewisx (SLEX) and sialylated SSEA-1 (S-Xi) in 136 cases of diagnosed lung cancer (63 adenocarcinoma, 45 squamous cell carcinoma, 20 small cell carcinoma and 8 large cell carcinoma) and 111 cases of benign pulmonary disease were measured. The positive rate of these markers in the primary lung cancer group was significantly higher than those in benign pulmonary diseases. The positive rates of serum SLEX and S-Xi in all lung cancer cases were 27.2% and 27.9%, respectively. The antigen levels in the sera were higher in adenocarcinoma as compared to other histologic types, and increased as the stage advanced. It was concluded that SLEX and S-Xi are very useful markers of lung cancer for diagnosis and monitoring the clinical status.
Mukae
H
H
Hirota
M
M
Morikawa
N
N
Oda
H
H
Sakito
O
O
Shikuwa
T
T
Senju
R
R
Fukushima
K
K
Hiratani
K
K
Kadota
J
J
D000230:Adenocarcinoma / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005732:Gangliosides / Q000097:blood*; D006017:Glycolipids / Q000097:blood*; D006801:Humans; D016256:Lewis X Antigen; D008175:Lung Neoplasms / Q000097:blood*
D014408:Biomarkers, Tumor; D005732:Gangliosides; D006017:Glycolipids; D016256:Lewis X Antigen