Syntheses of 24R,25-dihydroxy-[6,19,19-3H]vitamin D3 and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3.
24R,25-Dihydroxy-[6,19,19-3H]vitamin D3 with a specific activity of 54 Ci/mmol and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3 with 2.6 deuterium atoms/mol were synthesized in four steps starting from 24R,25-Dihydroxyvitamin D3 via its sulfur dioxide adduct.
Yamada
S
S
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Shimizu
M
M
Fukushima
K
K
Niimura
K
K
Maeda
Y
Y
D015650:24,25-Dihydroxyvitamin D 3 / Q000138:chemical synthesis*; D003903:Deuterium; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry; D013458:Sulfur Dioxide; D014316:Tritium
D013458:Sulfur Dioxide; D014316:Tritium; D015650:24,25-Dihydroxyvitamin D 3; D003903:Deuterium