Sympathectomy enhances the substance P-mediated breakdown of the blood-aqueous barrier in response to infrared irradiation of the rabbit iris.
Rabbits were subjected to infrared irradiation of the iris 1 month after unilateral cervical sympathectomy. The resulting breakdown of the blood-aqueous barrier was greatly enhanced on the sympathectomized side. In contrast, the response to intravitreally injected substance P (SP) was the same in both eyes. The enhancement of the response to IR irradiation could be abolished by pretreatment with an SP antagonist, (D-Pro2, D-Trp7,9)-SP.
Bynke
G
G
Bruun
A
A
Håkanson
R
R
D000818:Animals; D007259:Infrared Rays; D007498:Iris / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D011680:Pupil / Q000502:physiology; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology*; D013562:Sympathectomy
D013373:Substance P