[The effect of furanocoumarins on microsomal oxidation in the rat liver].
Puvalen and psoberan are inhibitors of monoxygenase enzyme system activity of the liver. Puvalen exerts the biphase effect on the system, so it may be referred to such classic inhibitors as SKF-525A and pyperonil butoxide. Psoberan does not exert the biphase effect on the monoxygenase system that is apparently connected with its negative action on biomembrane structure of hepatocytes. The results must be taken into consideration when patients are treated with psoralens.
Krakovskiĭ
M E
ME
Akovbian
V A
VA
Ashirmetov
A Kh
AKh
Komarin
A S
AS
D000078223:5-Methoxypsoralen; D000818:Animals; D000983:Antipyrine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000493:pharmacokinetics / Q000494:pharmacology; D005363:Ficusin / Q000493:pharmacokinetics / Q000494:pharmacology; D011564:Furocoumarins / Q000493:pharmacokinetics / Q000494:pharmacology; D006207:Half-Life; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D008730:Methoxsalen / Q000493:pharmacokinetics / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D004338:Drug Combinations; D011564:Furocoumarins; D000078223:5-Methoxypsoralen; C017687:psoberan; D006591:Hexobarbital; D005363:Ficusin; D000983:Antipyrine; D008730:Methoxsalen
Vliianie furanokumarinov na mikrosomal'noe okislenie v pecheni krys.