[Immune depression--a possible cause of the unfavorable course of pneumonia in chronic alcoholics].
In 27 patients, suffering with chronic alcoholism and hospitalized for pulmonary diseases in the Clinic of Pulmonology and Phthisiology, the following immunological characteristics were checked up: the functional activity of polymorphonuclear leukocytes and in 12 patients also that of alveolar macrophages were evaluated on the basis of the study of the phagocytic index and the phagocytic number, myeloperoxidase and the nitro blue tetrazolium test; the levels of serum IgG, IgA and IgM, the titer of the complement, E-rosette-forming cells (active and total) were also evaluated; the deficiency of cell-mediated immune response was determined by means of intradermal tests with the use of P.P.D., phytohemagglutinin, candidin, trichophytin. In all these investigations the depression of the functional activity of polymorphonuclear leukocytes and alveolar macrophages, dysimmunoglobulinemia, the increased level of circulating immune complexes and the suppression of cell-mediated immunity characteristics were revealed in the patients. Frequent infections and the severe course of bacterial and viral infections observed in such patients can be probably attributed to deficient cell-mediated immune response and to disturbances in phagocytosis.
Kis'ova
K
K
Iankov
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000276:immunology / Q000382:microbiology; D001419:Bacteria / Q000302:isolation & purification; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis / Q000276:immunology; D011014:Pneumonia / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D013183:Sputum / Q000382:microbiology
Immunnaia depressiia--vozmozhnaia prichina neblagopriiatnogo techeniia pnevmoniĭ u bol'nykh khronicheskim alkogolizmom.