[Proteolytic changes in plasma fibrinogen from ovarian venous blood in patients with cervix cancer].
From 9 female patients suffering from carcinoma cervicis (8 women with a stage Ib, 1 woman with a stage IIa carcinoma) blood was taken immediately from the ovarian veins and a cubital vein after laparotomy on the occasion of a surgical intervention according to Wertheim-Held. Fibrinogen was isolated from plasmas by affinity chromatography at fibrin monomer Sepharose and characterized by SDS-PAGE. With one exception proteolytically changed fibrinogens could be demonstrated in all plasmas. In 7 cases the fibrinogens from ovarian blood were more degraded than fibrinogen derivates in the blood obtained from cubital veins. It is assumed that the proteinase and/or plasminogen activator activities of tumor tissues are of importance for the observed proteolytic effects.
Lober
R
R
Krantz
S
S
Lober
M
M
Schütz
M
M
Göretzlehner
G
G
D000230:Adenocarcinoma / Q000097:blood; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply*; D010447:Peptide Hydrolases / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood*; D014680:Veins
D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010447:Peptide Hydrolases
Proteolytische Veränderungen des Plasmafibrinogens im Blut der Ovarialvenen von Patientinnen mit Zervixkarzinomen.