title: Improvement of peripheral circulation by low density lipoprotein adsorption.
abstract: Low density lipoprotein (LDL) was removed by repeated extracorporeal adsorption with a dextran sulphate cellulose column in 5 patients with clinical signs of poor peripheral circulation. The LDL apheresis was continued for 2 to 10 months, and symptoms such as cold or "heavy" legs, or intermittent claudication rapidly improved early in the treatment course in all 5 patients. Clearing of mentation occurred in 3, and recovery of kidney function was seen in 1 patient. These improvements occurred concomitant with a reduction in LDL level.
authors.affiliation: Department of Surgery, Kidney Center, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Agishi
authors.forename: Y
authors.initials: Y
authors.lastname: Kitano
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Miura
authors.forename: J
authors.initials: J
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Minagawa
authors.forename: K
authors.initials: K
authors.lastname: Ban
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000628:therapy*; D001781:Blood Component Removal; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000628:therapy*; D007511:Ischemia / Q000097:blood / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL