Lactobionic acid as an iron chelator: a rationale for its effectiveness as an organ preservant.
Lactobionic acid, a major constituent of a solution used to preserve organs prior to transplantation, can chelate ferric iron. This is evident by its ability to solubilize iron as well as changes that occur in the UV-VIS spectra of iron in its presence. Relative to iron (III) chelated to EDTA, the lactobionic acid-iron (III) complex is less able to participate in the Fenton reaction as measured by formaldehyde generation from DMSO and bleaching of p-N,N-dimethylnitrosoaniline. Similar effects are seen with citrate and ATP, two substances which also appear to be able to ameliorate ischemia/reperfusion injury. These findings present a rationale for the effectiveness of lactobionic acid as an organ preservant.
Isaacson
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Y
Department of Medicine, University of Pittsburgh, PA 15261.
Salem
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O
Shepherd
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Van Thiel
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DH
D002384:Catalysis; D004121:Dimethyl Sulfoxide / Q000378:metabolism; D004187:Disaccharides / Q000494:pharmacology*; D005557:Formaldehyde / Q000378:metabolism; D005609:Free Radicals; D007502:Iron Chelating Agents; D008968:Molecular Conformation; D009926:Organ Preservation; D015427:Reperfusion Injury / Q000517:prevention & control; D013056:Spectrophotometry, Ultraviolet
D004187:Disaccharides; D005609:Free Radicals; D007502:Iron Chelating Agents; D005557:Formaldehyde; C005608:lactobionic acid; D004121:Dimethyl Sulfoxide