Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
We examined the effect of human epidermal growth factor (hEGF) on the healing rate of gastric ulcers induced in rats. These ulcers were produced by a submucosal injection of 0.03 ml of 20% acetic acid into the stomach. Healing of the ulcers was delayed when a daily s.c. injection of indomethacin (1 mg/kg) was given for 4 wks. hEGF (100 and 300 micrograms/kg), given s.c. for 2 and 4 wks, significantly accelerated both natural and delayed healing of the ulcers. hEGF significantly inhibited both basal (pylorus ligation) and histamine-stimulated acid secretion (acute fistula). Thus, hEGF accelerates the healing of acetic acid-induced gastric ulcers, presumably because of its potent antisecretory activity.
Kuwahara
Y
Y
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Okabe
S
S
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects*
D000085:Acetates; D004815:Epidermal Growth Factor; D019342:Acetic Acid; D007213:Indomethacin