Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.
The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced urotoxicity of CPA. In contrast, simultaneous administration of DSF (200 mg/kg, p.o.) decreased the urotoxicity of CPA.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide / Q000633:toxicity*; D004221:Disulfiram / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000503:physiopathology
D000963:Antimetabolites; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide; D005978:Glutathione; D004221:Disulfiram