[A new diagnostic index of diabetes mellitus based on the 2-dimensional parameter of glucose kinetics].
A new approach to forming a one-part model of glucose kinetics in an i.v. tolerance test (IGTT) made it possible to introduce a two-dimensional parameter of glucose kinetics which reflected, on the one hand, the rate of glucose elimination from the blood and, on the other hand, glucose production by the liver during testing. This parameter serves the basis for a discriminant function which can be used for the identification of patients with diabetes mellitus with 100% reliability (22 patients and 50 healthy persons in a control sampling), overdiagnosis being made in 8% of the cases only. Another function characterizing a degree of carbohydrate metabolic derangement in persons with previously diagnosed diabetes is based on the same principle. Besides, a new highly reliable diagnostic criterion of diabetes mellitus was obtained taking into account a distance and position of the two-dimensional parameter of glucose kinetics with relation to a discriminant curve permitting quantitative characterization of carbohydrate metabolism in an examinee.
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D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D016002:Discriminant Analysis; D005951:Glucose Tolerance Test; D006801:Humans; D007700:Kinetics
D001786:Blood Glucose
Novyĭ diagnosticheskiĭ pokazatel' sakharnogo diabeta, osnovannyĭ na dvumernom parametre kinetiki gliukozy.