On the binding of brain myelin basic protein to chromatographic resins.
Myelin basic protein, only in association with certain detergents, is able to bind irreversibly to the usual gel filtration media. While this binding is greatly advantageous in purification of proteolipid (the other major myelin protein), the question arises of the uncommon, nonphysiological behaviour of the basic protein. A relationship between binding property and basic protein structure is suggested.
Riccio
P
P
De Santis
A
A
Bobba
A
A
Quagliariello
E
E
D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D004676:Myelin Basic Protein / Q000378:metabolism*; D012116:Resins, Plant / Q000378:metabolism*; D013329:Structure-Activity Relationship
D004676:Myelin Basic Protein; D012116:Resins, Plant