Effects of the duodenal ulcerogens, mepirizole and cysteamine, on gastric motility and emptying in rats.
Mepirizole (60 and 200 mg/kg, s. c.) and cysteamine (100 and 300 mg/kg, s. c.) markedly inhibited gastric motility in fasted rats. The inhibition caused with the low dose (non-ulcerogenic) of each agent reverted to control levels within 6 h. With high doses (ulcerogenic), however, the inhibition persisted for more than 9 h, and returned to control levels 12 h later. Gastric emptying of liquids was significantly delayed with ulcerogenic and non-ulcerogenic doses of the agents. Delayed emptying (gastric contents) persisted for 12 h with ulcerogenic doses, The pathogenetic relevance of this prolonged inhibition of gastric motility and emptying to ulcerogenecity was considered.
Tanaka
H
H
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Takeuchi
K
K
Okabe
S
S
D000818:Animals; D004396:Coloring Agents; D003543:Cysteamine / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced*; D004840:Epirizole / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004396:Coloring Agents; D011720:Pyrazoles; D004840:Epirizole; D003543:Cysteamine