title: Sympathetic innervation of pulmonary circulation and its role in hypoxic pulmonary vasoconstriction.
abstract: The purposes of this study were to localize the position of spinal center of sympathetic nerve which controls the pulmonary circulation, and to evaluate the role of pulmonary sympathetic nerve in hypoxic pulmonary vasoconstriction (HPV) in pithed rat model. The sympathetic preganglionic fibers arising from C7-T10 segments were stimulated electrically in succession. During stimulation the pulmonary vascular resistance (PVR) was increased in all segments tested, most significantly in C7-T4 (about 28% above control value), obviously higher than that in T5-T10. The higher the stimulated spinal segments, the larger the ratio of delta PVR/ delta SVR. Alveolar hypoxia (12% O2-88% N2) could induce HPV in pithed rat. In the presence of hypoxia, stimulation of T1-T3 segments caused a double increment in PVR and Ppa as compared with those during normoxia (P less than 0.05). The data show that 1) the spinal center of sympathetic nerve regulating the vasomotion of pulmonary circulation is located in the C7-T4 segments; 2) the excitation of sympathetic nervous system during hypoxia could enhance HPV.
authors.forename: Z
authors.initials: Z
authors.lastname: Ming
authors.forename: D X
authors.initials: DX
authors.lastname: Wang
mesh_terms: D000818:Animals; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000294:innervation*; D008297:Male; D011652:Pulmonary Circulation; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction