Transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials.
Autologous adrenal medullary tissue was transplanted to the striatum in two patients with severe parkinsonism. The aim was to provide the striatum with a new cellular source of catecholamines. Some rewarding effects were registered. This is the first time that such tissue has been transplanted in the human brain. The results merit further clinical trials.
Backlund
E O
EO
Granberg
P O
PO
Hamberger
B
B
Knutsson
E
E
Mårtensson
A
A
Sedvall
G
G
Seiger
A
A
Olson
L
L
D000313:Adrenal Medulla / Q000637:transplantation*; D002421:Caudate Nucleus / Q000502:physiology; D002986:Clinical Trials as Topic; D003342:Corpus Striatum / Q000502:physiology / Q000601:surgery*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009473:Neuronal Plasticity; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000601:surgery*; D011954:Receptors, Dopamine / Q000502:physiology; D013238:Stereotaxic Techniques; D009435:Synaptic Transmission; D014182:Transplantation, Autologous
D011954:Receptors, Dopamine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid