Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity.
Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2-, IgG- cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.
Strzadala
L
L
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Rak
I
I
Ziolo
E
E
Paprocka
M
M
Radzikowski
C
C
Den Otter
W
W
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000032:analysis*; D007074:Immunoglobulin G / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D009362:Neoplasm Metastasis; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D006028:Glycosphingolipids; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D003520:Cyclophosphamide