title: [Appearance of Philadelphia chromosome at relapse of erythroleukemia in a 12-year-old boy].
abstract: A 12-year-old boy was referred to our hospital because of anemia and jaundice. On admission bone marrow smears were compatible with M6 classification of the FAB, revealing 74.5% erythroblasts of all nucleated cells and 40% blasts of nonerythroid cells. Karyotype analysis revealed 46, XY. Gene rearrangement within the breakpoint cluster region (bcr) on chromosome 22 was negative at this time. Complete remission was attained by a combination chemotherapy. However, at 10 months of remission, cytogenetic studies of the bone marrow demonstrated Ph1 positive (10%). One month later, the patient fully relapsed with a 75% Ph1 positive karyotype associated with positive bcr. Subsequently, the patient died of refractory leukemia.
authors.forename: S
authors.initials: S
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Natsuyama
authors.forename: S
authors.initials: S
authors.lastname: Okano
authors.forename: T
authors.initials: T
authors.lastname: Hashida
authors.forename: H
authors.initials: H
authors.lastname: Fukumochi
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: S
authors.initials: S
authors.lastname: Imashuku
mesh_terms: D002648:Child; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D012008:Recurrence