Protection of acute ischemic myocardial injury by pharmacological intervention.
Pharmacological protection of acute ischemic myocardial injury was studied using diltiazem, bunazosin, coenzyme-Q10 (Co-Q), and nicorandil, in dogs of which the left anterior descending coronary artery was ligated for 60 min. Drugs were given intravenously prior to and/or during coronary ligation. Co-Q, bunazosin and diltiazem suppressed degradation of sarcoplasmic reticulum (SR) expressed as inhibitions of reduction in Ca++-dependent ATPase activity and degradation of major ATPase protein. Fine structures of ischemic myocardial cells were simultaneously retained as well. On the contrary, the effects of nicorandil on ischemic myocardial injury were few. It is likely that protection of ischemic myocardial injury could be expected with drugs which react with ischemic myocardium directly and inhibit excess inflow of extracellular Ca++ in ischemic myocardium.
Katagiri
T
T
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Mochizuki
M
M
Umetsu
K
K
Hiroshige
J
J
Geshi
E
E
Konno
N
N
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003067:Coenzymes; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control*; D004110:Diltiazem / Q000494:pharmacology*; D004285:Dogs; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D020108:Nicorandil; D011799:Quinazolines / Q000494:pharmacology*; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D003067:Coenzymes; D011799:Quinazolines; D014665:Vasodilator Agents; D014451:Ubiquinone; D009536:Niacinamide; D020108:Nicorandil; C018176:bunazosin; D000251:Adenosine Triphosphatases; D000252:Calcium-Transporting ATPases; D004110:Diltiazem; C024989:coenzyme Q10; D002118:Calcium