title: Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance.
abstract: A comparison was made of the phosphate content of the tight-junction-specific protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance, a parameter reflective of tight-junctional permeability. Analysis revealed that the ZO-1 from the low-resistance strain contained approximately twice as much phosphate as that from the high-resistance strain.
authors.affiliation: Department of Biology, Yale University, New Haven, CT 06511.
authors.forename: B R
authors.initials: BR
authors.lastname: Stevenson
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
authors.forename: I D
authors.initials: ID
authors.lastname: Braun
authors.forename: M S
authors.initials: MS
authors.lastname: Mooseker
mesh_terms: D000818:Animals; D002460:Cell Line; D002463:Cell Membrane Permeability; D004285:Dogs; D004553:Electric Conductivity; D004848:Epithelium / Q000502:physiology; D007365:Intercellular Junctions / Q000502:physiology*; D007668:Kidney / Q000502:physiology; D007700:Kinetics; D008565:Membrane Proteins / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D062826:Zonula Occludens-1 Protein
chemical_list: D008565:Membrane Proteins; D010710:Phosphates; D010750:Phosphoproteins; D062826:Zonula Occludens-1 Protein