title: Chronic idiopathic hyperphosphatasia and fibrous dysplasia in the same child.
abstract: A generalized skeletal dysplasia with features of chronic idiopathic hyperphosphatasia and fibrous dysplasia of the mandible were observed in a 6-year-old child. The abnormal development of the bones resulted from enhanced remodeling and the failure of mature bone to form. The occurrence of the two lesions in the same child and a review of the literature support the hypothesis that pathogenesis of fibrous dysplasia and idiopathic hyperphosphatasia reflect an underlying common defect in the control of bone cell activity.
authors.affiliation: Clinica Ortopedica dell'Università di Pavia, Italy.
authors.forename: U E
authors.initials: UE
authors.lastname: Pazzaglia
authors.forename: D
authors.initials: D
authors.lastname: Barbieri
authors.forename: G
authors.initials: G
authors.lastname: Beluffi
authors.forename: E
authors.initials: E
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: Grana
authors.forename: R
authors.initials: R
authors.lastname: Rosso
authors.forename: L
authors.initials: L
authors.lastname: Varesco
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D010710:Phosphates / Q000097:blood*; D011859:Radiography
chemical_list: D010710:Phosphates