Studies of the developmental toxicity of polycarboxylate dispersing agents.
Three linear polycarboxylate compounds, two linear polyacrylates (90,000 MW and 4,500 MW) and one linear polyacrylate-maleate copolymer (12,000 MW), were tested for their teratogenic potential in female Sprague Dawley rats. These polymers, which were tested as sodium salts, are used as dispersing agents in detergent formulations at levels of 1-5%. All compounds were administered by gavage during organogenesis (days 6-15 of pregnancy). No adverse effects on development were seen with any of the three compounds at any of the doses tested. The highest dose, and therefore the minimum no-effect dose, for the three linear polymers was 1125 mg/kg/day for the 90,000 MW polyacrylate, 3000 mg/kg/day for the 4,500 MW polyacrylate, and 6670 mg/kg/day for the polyacrylate-maleate copolymer. Based on these data, these compounds are not developmentally toxic, even at very high dose levels.
Nolen
G A
GA
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Monroe
A
A
Hassall
C D
CD
Iavicoli
J
J
Jamieson
R A
RA
Daston
G P
GP
D000180:Acrylic Resins / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002264:Carboxylic Acids / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D008970:Molecular Weight; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012972:Sodium Hydroxide; D013723:Teratogens
D000180:Acrylic Resins; D002264:Carboxylic Acids; D013723:Teratogens; C006903:carbopol 940; D012972:Sodium Hydroxide