title: Autoregulation of RNase III operon by mRNA processing.
abstract: RNase III has been implicated in the control of gene expression by the processing of mRNA. We have found that the rnc operon is autoregulated; rnc- mutant strains oversynthesize the operon's mRNA and protein products. A site in the 5'-noncoding region of the operon's message is cleaved by RNase III. This site-specific cleavage appears to be the initial step in the functional inactivation of the message, since the half-life of the cut message is dramatically shorter than that of the uncut message.
authors.affiliation: Laboratory of Chromosome Biology, Frederick Cancer Research Facility, MD 21701.
authors.forename: J C
authors.initials: JC
authors.lastname: Bardwell
authors.forename: P
authors.initials: P
authors.lastname: Régnier
authors.forename: S M
authors.initials: SM
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Grunberg-Manago
authors.forename: D L
authors.initials: DL
authors.lastname: Court
mesh_terms: D001483:Base Sequence; D004587:Electrophoresis, Agar Gel; D004722:Endoribonucleases / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006207:Half-Life; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D009876:Operon; D011233:Precipitin Tests; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D015183:Restriction Mapping; D043244:Ribonuclease III; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D004722:Endoribonucleases; D043244:Ribonuclease III