Opioid hypofunction in Parkinson's disease.
Loss of dopaminergic neuronal function has been the most consistent biochemical abnormality found in Parkinson's disease. Hypofunction of other transmitter systems has also been demonstrated in this disease. Recently, an opioid-dopamine link has been demonstrated. This paper provides evidence supporting an opioid system hypofunction in Parkinson's disease.
Sandyk
R
R
Gillman
M A
MA
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology; D004723:Endorphins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013373:Substance P / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D004723:Endorphins; D018377:Neurotransmitter Agents; D012701:Serotonin; D013373:Substance P; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D004298:Dopamine