The effect of angiotensin converting enzyme inhibitors (ACE-I) and selective beta 1-antagonists on bronchial reactivity and the cough reflex in man.
The non-specific bronchial reactivity and cough threshold of hypertensive patients on an ACE-I monotherapy regimen (either captopril or enalapril), a beta 1-antagonist monotherapy regimen (either atenolol or metoprolol) or a combination of an ACE-I with a beta 1-antagonist were determined in the present study. Forty-six hypertensives who were on these medications performed a histamine inhalation test (to assess bronchial reactivity) and a further 36 of these individuals participated in the citric acid test (to assess cough threshold). A control cohort consisting of 25 age-matched, drug-free subjects also performed the citric acid test. The incidence of bronchial hyperreactivity was not significantly different between the ACE-I monotherapy regimen and the beta 1-antagonist monotherapy regimen (Chi-squared = 0.248). However, when the monotherapy regimens were pooled and compared with the ACE-I and beta 1-antagonist combination regimen, the combination regimen was found to be associated with a significantly higher incidence of bronchial hyperreactivity (Chi-squared = 6.69). No difference was observed between the age-matched controls and the hypertensive patients in terms of their cough threshold.
Uzubalis
R I
RI
Department of Clinical Pharmacology, Royal Adelaide Hospital, Australia.
Frewin
D B
DB
Bushell
M K
MK
McEvoy
R D
RD
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects*; D002951:Citrates; D019343:Citric Acid; D003371:Cough / Q000503:physiopathology*; D005260:Female; D006633:Histamine Antagonists; D006801:Humans; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000187:drug effects*; D012129:Respiratory Function Tests
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002951:Citrates; D006633:Histamine Antagonists; D019343:Citric Acid