Effects of dihydroheptaprenol on neutrophil functions in calves.
Microemulsified dihydroheptaprenol (DHP) was administered intramuscularly to clinically healthy calves at doses of 4, 6 and 8 mg/kg body weight. Marked increase of neutrophil counts was observed 0.5, 1 and 2 days after the injection at a dose of 6 mg/kg. Nitroblue tetrazolium reducing activity of neutrophils was also obviously enhanced 1, 2 and 3 days after DHP administration. Phagocytic killing of Staphylococcus aureus by neutrophils was further enhanced markedly 1, 2 and 3 days after the drug injection at 6 mg/kg.
Yoneyama
O
O
Osame
S
S
Ichijo
S
S
Kimura
M
M
Araki
S
S
Suzuki
M
M
Imamura
E
E
D000818:Animals; D002417:Cattle / Q000097:blood*; D005260:Female; D007273:Injections, Intramuscular; D007958:Leukocyte Count / Q000187:drug effects / Q000662:veterinary; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology*
D013729:Terpenes; C053452:dihydroheptaprenol