T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes.
Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of receptors. If these receptors were chromosomally unlinked, karyotypically unstable T cell hybrids with dual reactivity for Mlsa,d and particular allo-H-2 determinants would be expected, occasionally, to lose reactivity for one set of determinants, but not the other. The results presented here provide direct support for this prediction.
Webb
S R
SR
Li
J H
JH
MacNeil
I
I
Marrack
P
P
Sprent
J
J
Wilson
D B
DB
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005802:Genes, MHC Class II; D005815:Genetic Code; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008912:Minor Histocompatibility Loci; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes; D006183:H-2 Antigens; D016169:Lymphocyte Function-Associated Antigen-1; D011948:Receptors, Antigen, T-Cell