Characterization of Chlamydia trachomatis serotypes by human T-lymphocyte clones.
T cells primed to Chlamydia trachomatis serotypes A, F, and K were cloned by limiting dilution. All T-lymphocyte clones obtained reacted only with C. trachomatis antigens. The proliferative capacity of 89 clones was studied with autologous non-T cells as antigen-presenting cells and the chlamydia serotypes A, B, D, F, K, and LGV-2 as antigens. Most of the clones reacted to several of the chlamydia strains, indicating common antigenic determinants. Other T-cell clones reacted with only a few serotypes. On the basis of the proliferation of the T-cell clones to the chlamydia strains and to interleukin-2, different reactivity patterns were obtained, which possibly can be used to differentiate among the chlamydia strains.
Qvigstad
E
E
Skaug
K
K
Hirschberg
H
H
D002692:Chlamydia trachomatis / Q000145:classification*; D002999:Clone Cells; D000939:Epitopes; D006801:Humans; D008213:Lymphocyte Activation; D012703:Serotyping; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes