TCGF III/P40 is produced by naive murine CD4+ T cells but is not a general T cell growth factor.
Several antigen-specific T cell lines were found to secrete a lymphokine upon activation by antigen or lectin that was provisionally termed T cell growth factor III (TCGF III) because it induced the proliferation of a CD4+ T cell clone independently from IL2 and IL4. Amino acid sequence analysis (and the functional properties of TCGF III) revealed that TCGF III was identical with a recently identified lymphokine termed P40. TCGF III/P40 was not only produced by long-term cultured T cell lines but also upon stimulation of freshly isolated Mlsa-reactive T cells. In addition, naive CD4+ T cells secreted TCGF III/P40 upon activation by lectin or allo-major histocompatibility complex structures. However, in spite of its growth-promoting activity for a CD4+ T cell clone this lymphokine does not appear to function as a general growth factor for T cells.
Schmitt
E
E
Institut für Immunologie der Johannes Gutenberg Universität, Mainz, FRG.
Van Brandwijk
R
R
Van Snick
J
J
Siebold
B
B
Rüde
E
E
D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002460:Cell Line; D006023:Glycoproteins / Q000235:genetics / Q000502:physiology*; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D016906:Interleukin-9; D007959:Lymphocyte Culture Test, Mixed; D008222:Lymphokines / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006023:Glycoproteins; D006133:Growth Substances; D007376:Interleukin-2; D016906:Interleukin-9; D008222:Lymphokines; D015847:Interleukin-4