[Pathogenesis of porphyrin-sensitized lethal and sub-lethal photo-injury].
By means of morphological methods the mechanisms of thanatogenesis were studied in 57 white mice after the hematoporphyrin derivative administration and xenon lamp radiation imitating the sun spectrum. In dependence of integrative doses of sensitized photoradiation and individual resistance of the organism there was observed immediate (hours), retained (days) and remote (weeks) death of animals. In the first two groups death came as a result of photocoagulation of plasma proteins and toxemic shock with liver, lung and brain injury, and in the third group--as a result of suppurative resorptive intoxication against the background of ulcerous skin necrosis.
Barabash
R D
RD
Normanskiĭ
V E
VE
Andreeva
K P
KP
Galil-Ogly
G A
GA
Kolobanov
A S
AS
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D006415:Hematoporphyrins / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D008028:Light Coagulation; D051379:Mice; D009336:Necrosis; D010787:Photosensitivity Disorders / Q000209:etiology* / Q000401:mortality; D012772:Shock, Septic / Q000209:etiology; D012883:Skin Ulcer / Q000209:etiology; D013472:Sunlight; D013997:Time Factors
D001798:Blood Proteins; D006415:Hematoporphyrins
Patogenez sensibilizirovannogo porfirinami letal'nogo i subletal'nogo fotopovrezhdeniia.