Prediction of strong antigenic determinant of seminalplasmin and ribonuclease from the amino acid sequence.
It has been reported earlier [Hopp, T.P. & Woods, K.R. (1981) Proc. Natl. Acad. Sci. US 78, 3824-3828] that the antigenic determinants of a protein can be delineated by examining the average local hydrophilicity values along the peptide chain. I have used this method to predict the strong antigenic determinants of two proteins, seminalplasmin and ribonuclease, of known sequence. In the former case, the N-terminal segment 1-14, and in the latter case the segments 27-38 and 80-86, are predicted to possess the antigenic determinants of the two proteins. Experimental verification already exists for the former case.
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D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D000939:Epitopes; D008297:Male; D011506:Proteins / Q000276:immunology*; D012259:Ribonuclease, Pancreatic / Q000276:immunology*; D012661:Semen / Q000276:immunology; D029607:Seminal Vesicle Secretory Proteins
D000939:Epitopes; D011506:Proteins; D029607:Seminal Vesicle Secretory Proteins; D012259:Ribonuclease, Pancreatic