MRI detects cerebral involvement in neurologically asymptomatic patients with adrenoleukodystrophy.
X-Linked adrenoleukodystrophy (ALD) is a peroxisomal disorder which affects the white matter of the CNS. MRI detected white matter lesions in 2 of 7 patients with biochemically proven ALD but without neurologic manifestations.
Aubourg
P
P
Department of Pediatric Endocrinology, Hôpital Saint Vincent de Paul, Paris, France.
Sellier
N
N
Chaussain
J L
JL
Kalifa
G
G
D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000175:diagnosis* / Q000503:physiopathology; D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D002549:Diffuse Cerebral Sclerosis of Schilder; D005069:Evaluation Studies as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009420:Nervous System / Q000503:physiopathology*; D012016:Reference Values