[Clinical and experimental studies of yiqi huoxue principles in treating ulcerative colitis].
Yiqi Huoxue principle (YH) was applied to treat 30 cases of ulcerative colitis while Yiqi Jianpi ( ) and Qingre Qushi ( ) principle (YJQQ), which had been proved its therapeutic effect, was used as the control therapy. The herbal medicines were taken by oral and enema. The course of treatment was 6 weeks. The length, wet and dry weights of thrombus, the platelet adherence and the r, k, Ma, M values of thrombelastogram were measured before and after medications. Before medication, the value mentioned above were all abnormal in both YH and YJQQ group. After medication, with alleviation of the symptoms and signs of the colitis, all these values trend gradually to normal levels (P less than 0.01). The rat models of ulcerative colitis were made by immunological and local stimulation methods. The models were divided into three groups: YH(I), YJQQ(II) and water group(III). Three weeks after medication, the results showed that the lesion degree of the colon, the length and weight both wet and dry thrombus were remarkably lower in group I than those in group III. It was also showed that there was a positive correlation between the lesion degree of colon and the dry weight of thrombus (r = 0.7941, P less than 0.01). It suggested that the therapeutic effects of YH was similar to those of YJQQ in treating ulcerative colitis.
Zhao
H
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Zhou
J Z
JZ
D000328:Adult; D000818:Animals; D003093:Colitis, Ulcerative / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010973:Platelet Adhesiveness / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013916:Thrombelastography
D004365:Drugs, Chinese Herbal