title: Alteration in temperature regulation induced by burn injury in the rat.
abstract: The preoptic anterior hypothalamus (POAH) of rats housed at three ambient temperatures was implanted with perfusion apparatuses. Response of heat production to displacement of POAH temperature was determined for control animals and animals with burns (31% +/- 3% total body surface area). At an ambient temperature of 22 degrees C there was a significant increase in thermosensitivity of the POAH for both control rats and rats with burns compared with thermosensitivity at 32 degrees C. Within ambient temperatures there was no effect on thermosensitivity detected for rats with burns compared with control rats. The threshold temperature for heat production was shifted significantly upward (p less than 0.05) both by a lower ambient temperature and by burn injury. The reference temperature for heat production was also shifted to the right by burn injury (p less than 0.05). The significant shifts to the right for threshold temperature and reference temperature for heat production enhance the organisms's ability to meet the stress of the hypermetabolic response. At a warm ambient temperature (32 degrees C) there are no significant differences in thermoregulation detected in animals with burns or control animals.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: F T
authors.initials: FT
authors.lastname: Caldwell
authors.forename: D B
authors.initials: DB
authors.lastname: Graves
authors.forename: B H
authors.initials: BH
authors.lastname: Wallace
authors.forename: D B
authors.initials: DB
authors.lastname: Moore
authors.forename: J H
authors.initials: JH
authors.lastname: Crabtree
mesh_terms: D000818:Animals; D001481:Basal Metabolism / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D002056:Burns / Q000503:physiopathology*; D002151:Calorimetry / Q000379:methods; D004734:Energy Metabolism / Q000502:physiology; D008297:Male; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains