title: [Synthesis of new derivatives of 5H-furo[3,2-g][1]benzopyran-5-one with potential beta-adrenolytic activity].
abstract: With the purpose of obtaining new compounds with antiarrhythmic activity, nine novel aminoalkanol derivatives of 5H-furo[3,2-g] [1]benzopyran-5-one were synthetized. In pharmacological studies, compound IX proved to display strong antiarrhythmic action, which in chloroform-induced arrhythmia was stronger from that of propranolol at three times lower acute toxicity.
authors.forename: T
authors.initials: T
authors.lastname: Zawadowski
authors.forename: J
authors.initials: J
authors.lastname: Turło
authors.forename: G
authors.initials: G
authors.lastname: Borkowska
mesh_terms: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001578:Benzopyrans; C063951:5H-furo(3,2-g)(1)benzopyran-5-one
vernacular_title: Synteza nowych pochodnych 5h-furo [3-2-g] [1]-benzopiran-5-onu o spodziewanym działaniu beta-adrenolitycznym.