Bioavailability of suckable tablets of oral N-acetylcysteine in man.
The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
De Bernardi di Valserra
M
M
Istituto di Farmacologia Medica II, Università degli Studi di Pavia, Italy.
Mautone
G
G
Barindelli
E
E
Lualdi
P
P
Feletti
F
F
Galmozzi
M R
MR
D000111:Acetylcysteine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004339:Drug Compounding; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013607:Tablets
D013607:Tablets; D000111:Acetylcysteine