title: Study of upper extremity growth and development using human embryos and computer-reconstructed models.
abstract: This study investigated the apical ectodermal ridge and early vasculature of the human limb bud by use of histologic techniques and a new method of computer modeling. Fourteen human embryos were studied (more than 10,000 sections) microscopically and the embryonic limbs were reconstructed three-dimensionally by use of a serialized programming method. The apical ectodermal ridge consists of an extensive band of specialized cells, located over the rim of the limb surmounting a strip of rapidly-dividing mesenchymal cells. It is consistently supplied by a large vessel that shows extensive central branching.
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda, Md.
authors.forename: A E
authors.initials: AE
authors.lastname: Seyfer
authors.forename: G
authors.initials: G
authors.lastname: Wind
authors.forename: R R
authors.initials: RR
authors.lastname: Martin
mesh_terms: D001132:Arm / Q000098:blood supply / Q000196:embryology / Q000254:growth & development*; D003198:Computer Simulation; D004475:Ectoderm / Q000502:physiology; D004622:Embryo, Mammalian / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000502:physiology; D008953:Models, Anatomic