[The adaptive cytoprotection of exocrine pancreas in rats].
A model of acute necroto-hemorrhagic pancreatitis was prepared by injecting 5% sodium taurocholate-trypsin solution directly into the pancreatic duct of the rat. Fourty eight hours before the preparation of acute pancreatitis, intraductal injection of 0.1%, 0.2% or 0.4% sodium taurocholate-trypsin solution as mild irritant was able to decrease the mortality to 27%, 17% and 17% respectively. The maximal elevation of the serum amylase concentration in acute pancreatitis was decreased to 43%, 47% and 54%, respectively. Microscopic examination of the pancreatic tissue of the rats which were alive after pretreatment of mild irritants showed that the acute pancreatitis was milder and there was a tendency to change to chronic pancreatitis. Thus, we conclude that there is a phenomenon of adaptive cytoprotection on the exocrine pancreas in rats. The mechanisms of the phenomenon remain to be explored.
Wang
L H
LH
Yu
J R
JR
Wang
C C
CC
D000208:Acute Disease; D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000008:administration & dosage; D014357:Trypsin / Q000008:administration & dosage
D013656:Taurocholic Acid; D014357:Trypsin