Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
Ikegami
T
T
Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis 46223.
Natsumeda
Y
Y
Weber
G
G
D000818:Animals; D019731:Carbon-Nitrogen Ligases; D003513:Cycloheximide / Q000494:pharmacology; D004347:Drug Interactions; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007555:Isoxazoles / Q000494:pharmacology*; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors*; D008025:Ligases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D010080:Oxazoles / Q000494:pharmacology*; D012254:Ribavirin / Q000031:analogs & derivatives / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007555:Isoxazoles; D010080:Oxazoles; D012263:Ribonucleosides; D012254:Ribavirin; D003513:Cycloheximide; D007168:IMP Dehydrogenase; D007658:Ketone Oxidoreductases; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C020828:GMP synthase (glutamine-hydrolyzing); C006303:acivicin; C033706:tiazofurin