[The role of prolactin in the pathogenesis of male sterility].
To study the causal relationship between the hormonal status and spermatographic data in sterile males, the authors investigated the correlations between the plasma levels of testosterone, estradiol, prolactin and gonadotrophin and certain parameters of spermograms and computed the correlative relationship of those values. The findings demonstrated the increased levels of prolactin (249.09 +/- 39.6 mu/U/ml), significantly exceeding the normal (132.6 +/- 32.4 mu/U/ml), a tendency towards a decrease in the levels of FSH and testosterone (up to 7.01 +/- 0.70 nmol/l versus 12.57 +/- 0.39 nmol/l in health) and manifest elevation of estradiol levels (up to 634.71 +/- 29.16 nmol/l versus 205.02 +/- 18.60 nmol/l), as well as its ratio to the testosterone levels. The number of spermatozoa in 1 ml was found decreased up to 29.6 +/- 4.10 million, the volume of ejaculate was reduced to 2.7 +/- 0.41 ml, while the percentage of immobile spermatozoa rose to 40.00 +/- 4.76. Despite of some pathological changes evidenced by spermograms, there was the only parameter--the volume of ejaculate--that was directly dependent on the levels of prolactin, their correlation was reversed. Decreased numbers of spermatozoa and their motility were not related to hyperprolactinemia. Moreover, there was a positive correlation between the levels of prolactin and the motility of spermatozoa in sterile patients. Therefore, decreased number and motility of spermatozoa turned to be dependent not on prolactin but sex hormone levels. However, ejaculation was found unfeasible in male with high levels of hyperprolactinemia.
Gladkova
A I
AI
Vasilatiĭ
S N
SN
Sidorova
I V
IV
D000328:Adult; D000818:Animals; D004958:Estradiol / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000209:etiology*; D008297:Male; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility; D013739:Testosterone / Q000097:blood
D006065:Gonadotropins, Pituitary; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin
Rol' prolaktina v patogeneze muzhskogo besplodiia.