Noradrenaline release in human corpus cavernosum and its modulation via presynaptic alpha 2-adrenoceptors.
Strips of human corpus cavernosum were incubated with 3H-noradrenaline and subsequently superfused with physiological salt solution containing desipramine and corticosterone. The electrically (0.66 Hz) evoked tritium overflow was abolished by tetrodotoxin or omission of Ca2+ from the superfusion fluid. The alpha 2-adrenoceptor agonist B-HT 920 (6-allyl-2-amino-5, 6, 7, 8-4H-thiazolo-5,4-d-azepine), inhibited the evoked overflow, whereas the alpha 1-adrenoceptor agonist, methoxamine, was ineffective. The alpha 2-adrenoceptor antagonist, rauwolscine, facilitated the evoked tritium overflow. It is concluded that the stimulation-evoked release of noradrenaline from the sympathetic nerve fibres of the human corpus cavernosum is modulated via presynaptic alpha 2-adrenoceptors.
Molderings
G J
GJ
Institute of Pharmacology and Toxicology, University of Bonn, FRG.
Göthert
M
M
Van Ahlen
H
H
Porst
H
H
D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000328:Adult; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010413:Penis / Q000294:innervation / Q000378:metabolism* / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine