title: Inhibition of clastogenic effect of radiation by Liv. 52 in the bone marrow of mice.
abstract: The frequency of micronuclei in bone marrow cells of mice treated or not with Liv. 52 and then exposed to 4.5 Gy of gamma-radiation was evaluated from 6 h to 14 days post irradiation. The frequency of micronuclei increased from 6 h to 24 h post irradiated in both irradiated groups and declined thereafter, the frequency of micronuclei remaining significantly lower in the Liv. 52-treated group. These data demonstrate that Liv. 52 protects the bone marrow of mice against radiation injury.
authors.affiliation: Department of Radiobiology, Kasturba Medical College, India.
authors.forename: G C
authors.initials: GC
authors.lastname: Jagetia
authors.forename: N G
authors.initials: NG
authors.lastname: Ganapathi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D004338:Drug Combinations / Q000494:pharmacology; D005720:Gamma Rays; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C002614:Liv 52