Time-dependent variation of HLA-antigen-frequencies in HIV-1-infection (1983-1988).
In a 5-year-study of HLA-phenotypes in 411 HIV-1-infected individuals, a progressive decrease of the formerly elevated frequency of HLA-DR5 has been observed. HLA-DR3 seems to have a protective effect. These results are discussed with respect to the mimicry-hypothesis of HLA and disease associations. Further preliminary results indicate that HIV-associated Kaposi's sarcoma could be associated with HLA-A28, and therefore might be a different etiologic entity than HIV-infection alone.
Kuntz
B M
BM
Institute of Bloodcoagulation & Transfusionmedicine, Heinrich-Heine-Universität, Düsseldorf, FRG.
Brüster
H T
HT
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D015497:HIV-1; D006680:HLA Antigens / Q000032:analysis*; D015795:HLA-B8 Antigen / Q000032:analysis; D015803:HLA-DR3 Antigen / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D015805:HLA-DR5 Antigen