title: [The immunomodulating action of combined therapy together with local UHF hyperthermia in osteogenic sarcoma in children].
abstract: The paper is concerned with immunological evaluation of different stages of combined therapy with local UHF hyperthermia in children with osteogenic sarcoma. Combined therapy (polychemo- and radiotherapy) was shown to cause a decrease in the number of immunocompetent cells, to enhance imbalance of immunoregulatory T-lymphocytes, to weaken T-lymphocyte function on PHA; immunosuppressive action of combined therapy did not depend on a tumor site. The incorporation of UHF-hyperthermia in the therapeutic scheme weakened the manifestations of secondary immunodeficiency, got back to normal the structure of T-lymphocyte population. A favorable immunomodulating effect of hyperthermia was more frequently observed in patients with crural bone tumors. The effect of hyperthermia was revealed after direct influence of thermotherapy but it was absent in continuation of combined treatment.
authors.forename: G S
authors.initials: GS
authors.lastname: Neprina
authors.forename: E S
authors.initials: ES
authors.lastname: Panteleeva
authors.forename: O E
authors.initials: OE
authors.lastname: Vatin
authors.forename: V A
authors.initials: VA
authors.lastname: Bizer
authors.forename: I N
authors.initials: IN
authors.lastname: Boĭko
mesh_terms: D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000276:immunology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008872:Microwaves / Q000627:therapeutic use*; D012516:Osteosarcoma / Q000276:immunology / Q000628:therapy*; D011859:Radiography; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D013601:T-Lymphocytes / Q000000981:diagnostic imaging / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic
vernacular_title: Immunomoduliruiushchee deĭstvie kombinirovannoĭ terapii v sochetanii s lokal'noĭ UVCh-gipertermieĭ pri osteogennoĭ sarkome u deteĭ.