Adenosine analogs elevate N-acetylserotonin and melatonin in rat pineal gland.
Adenosine, S-adenosyl-L-homocysteine, adenosine analogs such as 5'-N-ethylcarboxamidoadenosine and mioflazine, a nucleoside transport inhibitor, injected intraperitoneally at 09.00 h during the light period increased melatonin levels in the pineal gland of the rat. The largest increase occurred with 1 mg/kg 5'-N-ethylcarboxamidoadenosine. A representative time-response curve with 5'-N-ethylcarboxamidoadenosine (1 mg/kg) showed a maximal peak of N-acetylserotonin and melatonin 2 and 4 h after injection, respectively. These results are discussed in relation with the possible modulation through A2 receptors of melatonin synthesis in the pineal gland.
Gharib
A
A
INSERM U .205, Chimie Biologique INSA, Villeurbanne, France.
Reynaud
D
D
Sarda
N
N
Vivien-Roels
B
B
Pévet
P
P
Pacheco
H
H
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism
D012701:Serotonin; D019830:Adenosine-5'-(N-ethylcarboxamide); D008550:Melatonin; D000241:Adenosine; C006389:N-acetylserotonin