Changes in levels of mucosal glycoprotein on cysteamine-induced duodenal ulcers in rats.
Duodenal ulcers were induced in rats by cysteamine administration. Time-course changes in duodenal hexosamine, blood flow and intragastric pH were measured, as well as changes in the susceptibility of Brunner's glands to concanavalin A (Con A) staining. Hexosamine contents in the duodenum decreased significantly at 5 and 24 h. In the control group, Brunner's glands were stained brown using Con A staining. One day after cysteamine administration, the extent of Con A staining markedly decreased. At 3 and 7 days, gland susceptibility to staining was essentially the same as that of the control group.
Koga
K
K
Department of Internal Medicine, Tokyo Medical College, Japan.
Nonaka
Y
Y
Kawai
T
T
Seki
T
T
Kon
H
H
Tsurui
M
M
Ikeda
H
H
Harada
Y
Y
Saito
T
T
Ashizawa
S
S
D000818:Animals; D002011:Brunner Glands / Q000378:metabolism; D003208:Concanavalin A; D003543:Cysteamine / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced*; D004386:Duodenum / Q000098:blood supply / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000098:blood supply; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D006023:Glycoproteins; D006595:Hexosamines; C047874:gastric mucus glycoproteins; D003208:Concanavalin A; D003543:Cysteamine