UK-69,753, a novel member of the efrotomycin family of antibiotics. II. Structure determination and biological activity.
A novel antibiotic, UK-69,753, has been isolated from a submerged fermentation of Amycolatopsis orientalis strain N731-15. UK-69,753 has been assigned the structure 1 using spectroscopic means, primarily by NMR analysis. UK-69,753 is a glycoside of factumycin (A40A), a previously reported member of a small group of antibiotics related to aurodox and efrotomycin. UK-69,753 was shown to have potent activity both in vitro and in vivo against the swine pathogen Treponema hyodysenteriae.
Jefson
M R
MR
Pfizer Central Research, Groton, Connecticut.
Bordner
J
J
Reese
C P
CP
Whipple
E B
EB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011714:Pyrans / Q000494:pharmacology / Q000627:therapeutic use; D013057:Spectrum Analysis; D014211:Treponemal Infections / Q000188:drug therapy; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D011714:Pyrans; C058298:UK 69753