Diversity in the immune system: "preconceived ideas" or ideas preconceived?
Two concepts of the evolution and regulation of expression of the combining site repertoire of the immune system, are compared. One view is based on the Associative Recognition Theory as formulated by the author and the other is based on the Idiotype Network Idea as conceived by Jerne. The two concepts are analyzed from the point of view of their logic, internal consistency and factual support.
Cohn
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D000906:Antibodies / Q000235:genetics / Q000276:immunology; D000916:Antibody Diversity; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D005075:Biological Evolution; D003062:Codon; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D007107:Immune System; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D009154:Mutation; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014158:Transcription, Genetic
D000906:Antibodies; D003062:Codon; D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic