[The effect of alcohols on daily variations in aspartate amino- transferase activity in rat organs].
The 7 day-long intragastric administration of ethanol and ethyleneglycol in a dose of 1/3 DL50 was studied for its effect on the circadian variations of the aspartate aminotransferase activity (AST, EC 2.6, 1.1) in the liver, brain, myocardium and kidney of male rats. The ethanol and ethylene glycol administration reduced the mean circadian enzymic activity in the above organs. Moreover, ethanol significantly reduced the amplitude of circadian variations of the AST activity in the liver, brain and kidney, while ethylene glycol--in the liver, myocardium and kidney.
Korkach
V I
VI
Spitkovskaia
L D
LD
Kul'chitskaia
Iu G
IuG
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002940:Circadian Rhythm; D000431:Ethanol / Q000633:toxicity*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D005026:Ethylene Glycols; D000431:Ethanol; D001219:Aspartate Aminotransferases; D019855:Ethylene Glycol
Vliianie spirtov na sutochnye kolebaniia aktivnosti aspartataminotransferazy v organakh krys.