trans-activation by the hepatitis B virus X protein shows cell-type specificity.
The hepatitis B virus X protein can trans-activate transcription from many viral promoters. We show here that this trans-activation is cell-type but not species specific, and that only a subset of promoters is trans-activated in any particular cell type. Furthermore, the T/t-antigens from simian virus 40 suppress this trans-activation. We hypothesize that the X protein acts via cellular factors which are phylogenetically conserved and developmentally regulated and whose effects are blocked by the T/t-antigens.
Seto
E
E
Department of Pathology, University of California, San Francisco 94143.
Zhou
D X
DX
Peterlin
B M
BM
Yen
T S
TS
D000818:Animals; D002460:Cell Line; D006515:Hepatitis B virus / Q000235:genetics* / Q000502:physiology; D006801:Humans; D011401:Promoter Regions, Genetic; D013045:Species Specificity; D015534:Trans-Activators / Q000235:genetics*; D015533:Transcriptional Activation; D014162:Transfection; D054334:Viral Regulatory and Accessory Proteins
D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein