title: [The pharmacokinetic study of 3H-alpha-2-butylhydroxybenzyl alcohol in rabbits].
abstract: A derivative of Gastrodigenin, alpha-2-butylhydroxybenzyl alcohol, has shown a high distribution in the mice brain and stronger pharmacologic effects than its parent compounds. With 3H-alpha-2-butylhydroxybenzyl alcohol as radioactive tracer, pharmacokinetic data were obtained after the intravenous administration of a single dose alpha-2-butylhydroxybenzyl alcohol to rabbits, according to a cross-over design. Then, serial plasma samples were taken from 1 min to 480 min and measured by liquid scintillation counter. The data were analyzed by IBMPC computer for the estimation of pharmacokinetic parameters and the judgement of compartment model with a program recently developed by ourselves. The results suggested that the pharmacokinetics of alpha-2-butylhydroxybenzyl alcohol accords with the two compartment open model based on either the comparison of the calculated theoretic value with measured concentration or F test for the model judgement, and that the process of distribution was quite rapid, and the elimination half-life (T1/2 beta) was 12 h, indicating a slow elimination process.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Tan
authors.forename: A R
authors.initials: AR
authors.lastname: Kuang
authors.forename: Z P
authors.initials: ZP
authors.lastname: Guo
authors.forename: X C
authors.initials: XC
authors.lastname: Wu
authors.forename: T
authors.initials: T
authors.lastname: Li
mesh_terms: D000818:Animals; D001592:Benzyl Alcohols / Q000493:pharmacokinetics*; D001593:Benzyl Compounds / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits
chemical_list: D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D006993:Hypnotics and Sedatives; C061385:4-hydroxy-alpha-(1-methylpropyl)benzenemethanol