Influence of various adrenergic compounds on plasma potassium levels in conscious dogs and anaesthetized domestic pigs.
The influence of various compounds with affinity to beta-adrenoceptors on plasma potassium levels was investigated in conscious dogs and anaesthetized pigs. There was a marked fall, amounting to about 1 mmol/l following salbutamol and pirbuterol but nearly no effect following dobutamine and xamoterol. In dogs the hypokalaemic effect of salbutamol was augmented when prazosin was additionally applied. It is concluded, that the plasma potassium level is reduced mainly by beta 2-adrenoceptor stimulation. Blocking of alpha-adrenoceptors enhanced this effect and should therefore be avoided when beta 2-agonists are used therapeutically.
Stroman
F
F
Department of Pharmacology, Asta Pharma AG, Frankfurt/Main, Fed. Rep. of Germany.
Herold
H
H
Szelenyi
I
I
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D011188:Potassium / Q000097:blood*; D013552:Swine; D013566:Sympathomimetics / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D013566:Sympathomimetics; D004280:Dobutamine; C009118:pirbuterol; D000420:Albuterol; D011188:Potassium