[Genetics and coronary heart disease].
The article reviews some of the evidence that genetic factors are important in the etiology of coronary heart disease (CHD). Having a first degree relative with CHD at a relatively young age is in itself a risk factor that may not be reflected in increased lipid levels. Several genetic polymorphisms are associated with risk factor level and/or CHD, and genes have a significant effect on the level of several risk or "anti-risk" factors. Lp(a) lipoprotein, which exhibits a definite association with CHD, is under strict genetic control. A high level of Lp(a) lipoprotein does not in itself result in increased lipid levels, and it is therefore necessary to conduct specific tests with regard to this important genetic risk factor. DNA variation at several apolipoprotein loci has been examined and several associations with risk factor levels have been reported. Present knowledge of genetic predisposition to CHD should be utilized in predictive genetic testing to prevent disease, preferably within a framework of family-oriented preventive medicine.
Berg
K
K
D003327:Coronary Disease / Q000209:etiology / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012307:Risk Factors
D008055:Lipids; D004247:DNA
Genetikk og koronar hjertesykdom.