A structural and dynamic molecular model for the sodium channel of Electrophorus electricus.
Chemical logic and single group rotation (SGR) theory are applied to the primary structure determined by Noda et al. [(1984) Nature 312, 121-127] to construct a molecular model of the sodium channel of Electrophorus electricus. Both structural and dynamic aspects of the channel are accounted for, including gating current, sensitivity to changes in membrane potential, channel opening, a binding site for sodium, selectivity for sodium over potassium, capacity for rapid sodium flow, sensitivity to batrachotoxin (or other toxins) and inactivation.
Kosower
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D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004593:Electrophorus / Q000033:anatomy & histology*; D004594:Electrophysiology; D006023:Glycoproteins; D007473:Ion Channels / Q000502:physiology / Q000648:ultrastructure*; D008564:Membrane Potentials; D008958:Models, Molecular; D010766:Phosphorylation; D011188:Potassium / Q000378:metabolism; D011487:Protein Conformation; D012964:Sodium / Q000378:metabolism*; D014118:Toxins, Biological / Q000494:pharmacology
D006023:Glycoproteins; D007473:Ion Channels; D014118:Toxins, Biological; D012964:Sodium; D011188:Potassium