title: Effects of keto-analogues on phosphocalcic and aminoacid metabolism in dialysed patients: a crossover study.
abstract: It has been suggested that calcium salts of keto-analogues (KA) have beneficial effects on phosphocalcic and aminoacid (AA) metabolism. To confirm this, their short-term effects were evaluated on chronic dialyzed patients. In a prospective, randomised, crossover study, eight and seven patients were put on KA (200 mg/kg/d) and assigned either a low-protein diet (LP:0.4 g/kg/d) or a normal one (NP: 1 g/kg/d) for 15 days. The two treatments were interchanged after 15 days of washout. KA.LP was accompanied by: a) decreases in calorie intake (12%; p = 0.001) and in blood concentrations of albumin (5%, p = 0.004), urea (32%, p = 0.001), phosphate (29%, p = 0.001), parathormone (27%, p = 0.008), isoleucine (24%, p = 0.04), 1 and 3 methyl-histidine (71%, p = 0.03; 24%, p = 0.005), valine (19%, p = 0.004) and hydroxyproline (85%, p = 0.009); b) increases in calcemia (9%, p = 0.002), cystathionine (991%, p = 0.0001) and threonine (22%, p = 0.04). KA.NP was accompanied by: a) decreases in phosphatemia (15%, p = 0.03) and parathormone (18%, p = 0.06); b) increases in calcemia (9%, p = 0.002), cystathionine (427%, p = 0.0001), and phenylalanine (28%, p = 0.013). Calcium salts of keto-analogues together with a low or normal protein diet thus seem to reduce blood concentrations of phosphates and parathormone, and raise calcium; however their action on aminoacids needs further investigation.
authors.affiliation: Hemodialysis Unit Centre Hospitalier, Cholet, France.
authors.forename: M D
authors.initials: MD
authors.lastname: Mahmoud
authors.forename: V
authors.initials: V
authors.lastname: Bouche
authors.forename: P
authors.initials: P
authors.lastname: Collin
authors.forename: A
authors.initials: A
authors.lastname: Girault
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D002149:Energy Intake; D005260:Female; D006801:Humans; D007651:Keto Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism*; D011446:Prospective Studies; D011897:Random Allocation; D006435:Renal Dialysis
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins; D007651:Keto Acids; D010710:Phosphates; D002118:Calcium