Carbon tetrachloride-induced liver cell injury in the Mongolian gerbil (Meriones unguiculatus).
1. Male Mongolian gerbils (Meriones unguiculatus) liver activates CCl4 to free radicals that bind covalently to cellular components (CB) and stimulate a lipid peroxidation (LP) process to a larger extent than the rat liver. 2. CCl4 administration results in a less intense necrogenic effect in gerbils than in rats and does not cause fatty liver. 3. CCl4 causes less intense effects on liver ultrastructure or calcium metabolism but more marked depression of glucose 6 phosphatase activity (G6P-ase) in gerbils than in rats. 4. Results suggest that a better ability of gerbil liver to keep calcium homeostasis than rat liver might be the cause of their relative resistance to necrosis. Higher intensity of CB and LP in gerbils than in rats might explain more intense effects on G6P-ase.
de Perez
O A
OA
Centro de Diagnóstico e Investigaciones Veterinarias Formosa (CEDIVEF), Formosa.
de Ferreyra
E C
EC
Bernacchi
A S
AS
Villarruel
M C
MC
de Fenos
O M
OM
Castro
J A
JA
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005849:Gerbillinae / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007521:Isocitrate Dehydrogenase; D000633:Aminopyrine N-Demethylase; D005952:Glucose-6-Phosphatase; D002118:Calcium