Central action of substance P: possible role in reward.
A series of studies had revealed a dualistic role of post-trial injections of substance P in affecting avoidance behavior depending on the site of the brain in which it is applied. Based on these data, the hypothesis was formulated that substance P has brain site-dependent rewarding and punishing properties, a possibility which was assessed in rats trained on a modified T-maze task. Injections of substance P into the medial forebrain bundle (100 ng) or medial septal nucleus (500 ng) served as a positive reinforcer for conditioned place preference learning in the T maze. Injections into the amygdala (50 ng) or substantia nigra (100 ng) did not have such reinforcing properties.
Stäubli
U
U
Huston
J P
JP
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003216:Conditioning, Operant / Q000502:physiology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D051381:Rats; D012201:Reward; D012686:Septal Nuclei / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D013378:Substantia Nigra / Q000187:drug effects
D013373:Substance P