title: Hairy cell leukemia with an autoimmune syndrome, paraproteinemia, and cryoglobulinemia.
abstract: We have described an 82-year-old man with HCL who had autoimmune manifestations, paraproteinemia, and cryoglobulinemia. Chemotherapy resulted in a dramatic response, with a decrease in the tumor mass, a reduction in the clinical and serologic features of the autoimmune syndrome, and disappearance of the cryoglobulin, but without a significant change in the serum level of paraprotein.
authors.affiliation: Department of Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Shpilberg
authors.forename: M
authors.initials: M
authors.lastname: Ehrenfeld
authors.forename: M
authors.initials: M
authors.lastname: Berkovitz
authors.forename: M K
authors.initials: MK
authors.lastname: Maier
authors.forename: Y
authors.initials: Y
authors.lastname: Samra
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology*; D002699:Chlorambucil / Q000627:therapeutic use; D003449:Cryoglobulinemia / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010265:Paraproteinemias / Q000209:etiology*
chemical_list: D007075:Immunoglobulin M; D002699:Chlorambucil