title: Sustained cytopenia after leukapheresis for collection of peripheral blood stem cells in small children.
abstract: Marked and persistent cytopenia was observed in two 3-year-old children with cancer, after lymphopheresis to collect peripheral blood stem cells (PBSC) for autotransplantation after high-dose chemotherapy. This finding suggests that PBSC are a major component of the hematopoietic cells in small children and, hence, that special care is necessary in the construction of a protocol for collection of stem cells from young children.
authors.affiliation: Department of Pediatrics, University Hospital of Tokushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Koyama
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Suzue
authors.forename: T
authors.initials: T
authors.lastname: Shimokawa
authors.forename: T
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D002675:Child, Preschool; D002985:Clinical Protocols; D005260:Female; D006410:Hematopoiesis / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007937:Leukapheresis / Q000009:adverse effects*; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000628:therapy*; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000628:therapy*; D012008:Recurrence