title: Induction of hair growth in alopecia totalis with diphencyprone sensitization.
abstract: The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89%), and 13 of these agreed to proceed to repeated intermittent applications to the left side of the scalp, the right side acting as an untreated control; six subjects achieved cosmetically useful regrowth of normally pigmented terminal hair. No clinical features seemed to distinguish those who showed a favourable response from those who did not.
authors.forename: B
authors.initials: B
authors.lastname: Monk
mesh_terms: D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D000506:Alopecia Areata / Q000188:drug therapy; D002648:Child; D003521:Cyclopropanes / Q000627:therapeutic use*; D005260:Female; D006197:Hair / Q000254:growth & development*; D006801:Humans; D008297:Male
chemical_list: D003521:Cyclopropanes; C029402:diphenylcyclopropenone