title: Relationship of mortality, occupation, and pulmonary diffusing capacity to pleural thickening in the First National Health and Nutrition Examination Survey.
abstract: We studied the relationship of pleural thickening consistent with asbestos exposure to mortality, career employment in asbestos-related jobs, and pulmonary diffusing capacity among participants in the first National Health and Nutrition Examination Survey. Three "B" readers examined chest X-rays to identify 59 individuals with such pleural abnormalities. From 1975 to 1984, the all-cause mortality rate ratio (RR) comparing males with and without occupational pleural thickening was 1.3 (95% C.I. 0.8-2.2). For lung cancer, the mortality RR for males was 3.0 (95% C.I. 1.0-9.1). Career asbestos work was not associated with occupational pleural thickening among men, probably because some with the condition had only short-term exposure to asbestos. Pulmonary diffusing capacity was lower in those with occupational pleural thickening, taking smoking into account. These results suggest that individuals in the general population who have occupational pleural thickening are at risk for some of the health consequences of asbestos work, including lung cancer, even if they were not career asbestos workers.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
authors.forename: D P
authors.initials: DP
authors.lastname: Loomis
authors.forename: G W
authors.initials: GW
authors.lastname: Collman
authors.forename: W J
authors.initials: WJ
authors.lastname: Rogan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D005260:Female; D006306:Health Surveys; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009790:Occupations / Q000706:statistics & numerical data*; D016017:Odds Ratio; D010995:Pleural Diseases / Q000453:epidemiology / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D011009:Pneumoconiosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D011653:Pulmonary Diffusing Capacity / Q000502:physiology*; D012907:Smoking / Q000009:adverse effects; D014481:United States
chemical_list: D001194:Asbestos