Evaluation of nickel complexes of bioligands-effect on distribution profile.
Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation is subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.
Srivastava
R C
RC
Toxicokinetic Division, Industrial Toxicology Research Centre, Lucknow, India.
Srivastava
S K
SK
Gupta
S
S
Athar
M
M
Hasan
S K
SK
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009532:Nickel / Q000493:pharmacokinetics*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
D008024:Ligands; D006639:Histidine; D009532:Nickel; D005978:Glutathione