Histamine-release induced by 7S nerve-growth factor of mouse submandibular salivary glands.
The 7S nerve-growth factor (7S NGF) purified from mouse submandibular glands induced histamine release from rat-isolated mast cells in the presence of lysophosphatidyl-serine. When 7S NGF was injected intradermally into the rat skin, the vascular permeability increased. This response was abolished by the antihistamine, diphenhydramine. These results show that 7S NGF acts as a potent histamine releaser.
Sugiyama
K
K
Suzuki
Y
Y
Furuta
H
H
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D004155:Diphenhydramine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008246:Lysophospholipids; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000494:pharmacology; D012867:Skin / Q000187:drug effects; D013363:Submandibular Gland / Q000378:metabolism
C013614:7S nerve growth factor complex; C488870:7S nerve growth factor protein, rat; D008246:Lysophospholipids; D009414:Nerve Growth Factors; D010718:Phosphatidylserines; C025059:lysophosphatidylserine; D004155:Diphenhydramine