Zollinger-Ellison syndrome in a patient with normal screening gastrin level.
A 59-year-old female presented with multifocal peptic ulcer disease and diarrhea. A fasting serum gastrin level obtained while the patient was receiving no antacid therapy was normal. A secretin stimulation test was positive. A small gastrinoma was found in the anterior duodenal wall at exploratory laparotomy. Normal fasting gastrin levels do occur in patients with overt Zollinger-Ellison syndrome and should not deter further investigation if clinical suspicion of this syndrome is high.
Yanda
R J
RJ
Department of Medicine, University of California, San Francisco.
Ostroff
J W
JW
Ashbaugh
C D
CD
Guis
M S
MS
Goldberg
H I
HI
D004379:Duodenal Neoplasms / Q000097:blood* / Q000175:diagnosis; D005260:Female; D015408:Gastrinoma / Q000097:blood* / Q000175:diagnosis; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D015043:Zollinger-Ellison Syndrome / Q000097:blood* / Q000175:diagnosis
D005755:Gastrins