Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.
The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective remission was observed within 3 months and salazosulfapyridine was withdrawn after a further 6 months of therapy. At 6 years of age clinical and radiological recurrence of gastric obstruction was observed. Salazosulfapyridine was reinstated and continued as maintenance therapy. The child has been well for more than 4 years. Salazosulfapyridine therapy can be recommended as safe conservative treatment of gastric obstruction in CGD.
Stopyrowa
J
J
Second Department of Paediatrics, Institute of Paediatrics, Copernicus Medical School, Cracow, Poland.
Fyderek
K
K
Sikorska
B
B
Kowalczyk
D
D
Zembala
M
M
D002648:Child; D004338:Drug Combinations / Q000627:therapeutic use; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D008297:Male; D011859:Radiography; D013277:Stomach Volvulus / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D012460:Sulfasalazine / Q000627:therapeutic use*
D004338:Drug Combinations; C028423:Salazopyrine; D012460:Sulfasalazine; D005944:Glucosamine