title: Synthesis and CNS activity of some new substituted indeno [1,2-c] pyrazoles.
abstract: Some new 1-(6'-substituted-4'-methylquinol-2'-yl)-3-methyl-indeno[1,2- c]pyrazoles (Va-d) have been synthesized by the condensation of 2-acetylindane-1,3-dione (I) with 2-hydrazino-4-methyl-6-substituted quinolines (IIa-d), followed by cyclodehydration with polyphosphoric acid and Wolff-Kishner reduction. Compounds (IVa-d) showed noticeable CNS activity.
authors.affiliation: Department of Applied Chemistry, Banaras Hindu University, Varanasi, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Quraishi
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012119:Respiration / Q000187:drug effects; D013055:Spectrophotometry, Infrared
chemical_list: D002491:Central Nervous System Agents; D007192:Indenes; D011720:Pyrazoles