Increase of muscarinic cholinergic receptors in the rat submandibular glands after parasympathectomy and repeated administration of haloperidol.
1. The mechanisms of the supersensitivity to cholinergic drugs after chronic haloperidol was studied in normal and parasympathectomized submandibular glands of the rats. 2. Both parasympathectomy and haloperidol treatment for 7 days (2 mg/kg/day, i.p.) increased the sialogogue response of the glands to methacholine, a cholinomimetic drug. 3. Both denervation and haloperidol administration induce up-regulation of the muscarinic receptors as expressed per gram of the tissue. 4. Haloperidol causes no further increase in sensitivity than denervation alone. 5. These data demonstrate that secretory supersensitivity to cholinergic drugs in the rat submandibular glands, after chronic haloperidol and parasympathectomy is related to an increase in muscarinic cholinergic receptors.
Pazo
J H
JH
Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Rascovsky
S
S
Jerusalinsky
D
D
Medina
J H
JH
Tumilasci
O R
OR
D000818:Animals; D003714:Denervation; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D011813:Quinuclidinyl Benzilate; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D008688:Methacholine Compounds; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D006220:Haloperidol