[Application of multi-lines fitting technic for ethenzamide elimination with capacity-limited process in the rabbit plasma].
Intravenous and oral administrations of ethenzamide (EZ) were carried out in the rabbit, and elimination process pharmokinetically discussed. When the drug dose increased, plasma clearance and extent of bioavailability were reduced and plasma peak times delayed after oral dose of EZ. Michaelis-Menten type elimination parameters were estimated from the plasma concentration-time profiles after intravenous dosing of EZ. The first-order absorption rate constant (ka), hepatic available fraction (FH) and approximate elimination rate constant (K) for hepatic first-pass metabolism of EZ were estimated using computer multi-lines fitting technique by iterative nonlinear least squares regression program, MULTI (RUNGE).
Asada
S
S
Fujii
H
H
Nakae
H
H
D000818:Animals; D001682:Biological Availability; D003201:Computers; D008099:Liver / Q000378:metabolism; D011817:Rabbits; D012457:Salicylamides / Q000097:blood / Q000493:pharmacokinetics*
D012457:Salicylamides; C018935:ethenzamide