Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.
The mammalian tachykinins substance K, neuromedin K and substance P stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain. In contrast, none of these peptides had any effect on either basal or forskolin-stimulated cyclic AMP levels. The present results therefore implicate inositol phospholipid hydrolysis as a possible second messenger system mediating the effects of substance K and neuromedin K in addition to substance P.
Hunter
J C
JC
Goedert
M
M
Pinnock
R D
RD
D000818:Animals; D001921:Brain / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D015288:Neurokinin A; D015287:Neurokinin B; D009842:Oligopeptides / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D010716:Phosphatidylinositols; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B; D000242:Cyclic AMP