Inhibitory effect of hydroxyzine on antigen-induced histamine release in vivo.
By use of a modified heat-suction, skin blister technique, we found that oral hydroxyzine, 25 mg four times a day, inhibits antigen-induced ultrastructural changes of mast cells and in vivo histamine release in the skin of ragweed-sensitive individuals. To our knowledge this is the first demonstration that an orally active antihistamine can inhibit in vivo cutaneous anaphylactic reactions.
Ting
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Rauls
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Reiman
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D000284:Administration, Oral; D000328:Adult; D000941:Antigens / Q000494:pharmacology*; D001706:Biopsy; D006636:Histamine Release / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D008722:Methods; D012867:Skin / Q000473:pathology; D013396:Suction
D000941:Antigens; D006919:Hydroxyzine