A requirement for low concentration of hepatic glutathione for induction of gammaglutamyltransferase by phenobarbitone.
The effect of low concentration of hepatic glutathione on the induction of GGT by phenobarbitone was investigated. Rats were treated with diethyl maleate to decrease the hepatic concentration of GGT and with cysteine to increase glutathione concentration in the liver. All animals were then treated with phenobarbitone. The study shows that the induction of GGT is promoted by low concentration of hepatic glutathione.
Braide
S A
SA
Department of Pathology, University of Leicester, UK.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005978:Glutathione / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D008298:Maleates; D005723:gamma-Glutamyltransferase; C014476:diethyl maleate; D005978:Glutathione; D010634:Phenobarbital