title: [Muscle weakness and intolerance to exercise in mitochondrial myopathies].
abstract: Muscle weakness and intolerance to exercise are two of the main features commonly shown by patients affected by mitochondrial myopathies. In order to obtain an objective and quantitative evaluation of muscle weakness and endurance, we studied an evaluation protocol devoted to the assessment of 1) muscle strength by the isokinetic ergometer and 2) the metabolic aspects of exercise by means of Maximal Oxygen Consumption and endurance by a Steady State Submaximal exercise evaluation. The protocol has been applied to the study of patients affected by mitochondrial diseases and proved to be a reliable method to quantitate the defect in the oxidation pathways, either before or during the therapeutic follow-up.
authors.forename: D
authors.initials: D
authors.lastname: Peluchetti
authors.forename: C
authors.initials: C
authors.lastname: Antozzi
authors.forename: G S
authors.initials: GS
authors.lastname: Roi
authors.forename: M
authors.initials: M
authors.lastname: Rimoldi
authors.forename: F
authors.initials: F
authors.lastname: Cornelio
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009119:Muscle Contraction; D009135:Muscular Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D010101:Oxygen Consumption; D005082:Physical Exertion; D012256:Riboflavin / Q000627:therapeutic use
chemical_list: D012256:Riboflavin
vernacular_title: Valutazione della forza e dell'energetica muscolare nelle miopatie mitocondriali.