title: Two subtypes of sodium channel with tetrodotoxin sensitivity and insensitivity detected in denervated mammalian skeletal muscle.
abstract: The action potential (AP) in most nerve and muscle preparations depends upon nanomolar concentrations of the neurotoxins saxitoxin (STX) and tetrodotoxin (TTX). In some excitable tissues lacking mature innervation, a toxin-resistant AP has been described by electrophysiological results. However, multiple attempts to detect corresponding toxin-resistant Na channels with radiolabelled STX and TTX have been unsuccessful. We report here the detection of Na channels with low-affinity binding of STX and TTX, accounting for 50-60% of the Na channels in rat hindlimb muscle 4-5 days after denervation.
authors.forename: R B
authors.initials: RB
authors.lastname: Rogart
authors.forename: L J
authors.initials: LJ
authors.lastname: Regan
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004351:Drug Resistance; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D009121:Muscle Denervation; D009132:Muscles / Q000378:metabolism*; D009431:Neural Conduction; D051381:Rats; D012530:Saxitoxin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology*
chemical_list: D007473:Ion Channels; D012530:Saxitoxin; D013779:Tetrodotoxin; D012964:Sodium