[The antihypoxic activity of endogenous cyclic derivatives of gamma-aminobutyric acid].
Pirrolidone-2, gamma-butyrolacton, succinic anhydride were found to possess pronounced antihypoxic activity that manifested itself in their ability to decrease the level of lactic acid accumulated during hypoxia. Pirrolidone-2 and succinic anhydride increase succinic dehydrogenase activity in vitro. At intraperitoneal administration the above mentioned compounds lead to lactate dehydrogenase activity inhibition under normal conditions while during circulatory hypoxia they stimulate lactate dehydrogenase reaction promoting the maintenance of energy balance of the cerebral tissue at the appropriate level.
Mirzoian
S A
SA
Ekavian
A G
AG
Balasanian
M G
MG
Topchian
A V
AV
D015107:4-Butyrolactone / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D011760:Pyrrolidinones / Q000627:therapeutic use; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013387:Succinic Anhydrides / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D007773:Lactates; D011760:Pyrrolidinones; D011773:Pyruvates; D013387:Succinic Anhydrides; D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; C031801:succinic anhydride; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D015107:4-Butyrolactone
Antigipoksicheskaia aktivnost' éndogennykh tsiklicheskikh proizvodnykh gamma-aminomaslianoĭ kisloty.