Hepatotoxicity in albino rats exposed to n-octane and n-nonane.
Effects of n-octane and n-nonane (1 ml per kg body weight daily) on hepatic and serum enzymes, which reflect abnormal liver function and concentration of lipid and nucleic acid (serum and liver), were studied after 2 and 7 days intraperitoneal administration to albino rats. Decreased activities of serum acetylcholine esterase and carboxyl esterase were observed, together with an increase in FDP aldolase activity. Significant decrease in the concentration of albumin, total protein, and total and esterified cholesterol in serum have been noted after n-octane and n-nonane administration for 7 days. Also, free cholesterol content of liver was elevated significantly after solvents exposure.
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D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000378:metabolism; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D009795:Octanes / Q000633:toxicity*; D012313:RNA / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000473:Alkanes; D001798:Blood Proteins; D009795:Octanes; D012313:RNA; D004247:DNA; D002784:Cholesterol; C017573:nonane; C026728:octane