title: Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations.
abstract: The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind, latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.
authors.affiliation: Institute of Neurological Sciences, First Faculty of Medicine, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Tedeschi
authors.forename: G
authors.initials: G
authors.lastname: Casucci
authors.forename: S
authors.initials: S
authors.lastname: Allocca
authors.forename: R
authors.initials: R
authors.lastname: Riva
authors.forename: A
authors.initials: A
authors.lastname: Di Costanzo
authors.forename: A
authors.initials: A
authors.lastname: Quattrone
authors.forename: A
authors.initials: A
authors.lastname: Baruzzi
authors.forename: V
authors.initials: V
authors.lastname: Bonavita
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology*; D003201:Computers; D005133:Eye Movements / Q000187:drug effects*; D006801:Humans; D008297:Male; D012438:Saccades / Q000187:drug effects*
chemical_list: D002220:Carbamazepine