The relationship between adaptive cytoprotection and prostaglandin contents in the rat stomachs after oral administration of 0.35 N HCl.
Oral administration of a mild irritant, 0.35 N HCl, protected the gastric mucosa of rats against 0.6 N HCl-induced gastric lesions for 2 h. With prior administration of 0.35 N HCl, the PGE2 and PGF2 alpha contents in the fundic mucosa, as measured with a capillary gas chromatograph and a mass spectrometer, significantly increased until 1 h, but the PGD2, 6-keto-PGF1 alpha and TXB2 contents did not increase. These results suggest that the increases in gastric mucosal PG contents caused by the mild irritant protect the gastric mucosa against the strong irritant indirectly.
Orihata
M
M
First Department of Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Watanabe
Y
Y
Tanaka
M
M
Okubo
T
T
Sakakibara
N
N
D000222:Adaptation, Physiological; D000284:Administration, Oral; D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D006851:Hydrochloric Acid / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D009994:Osmolar Concentration; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D006851:Hydrochloric Acid