[Appearance of Philadelphia chromosome at relapse of erythroleukemia in a 12-year-old boy].
A 12-year-old boy was referred to our hospital because of anemia and jaundice. On admission bone marrow smears were compatible with M6 classification of the FAB, revealing 74.5% erythroblasts of all nucleated cells and 40% blasts of nonerythroid cells. Karyotype analysis revealed 46, XY. Gene rearrangement within the breakpoint cluster region (bcr) on chromosome 22 was negative at this time. Complete remission was attained by a combination chemotherapy. However, at 10 months of remission, cytogenetic studies of the bone marrow demonstrated Ph1 positive (10%). One month later, the patient fully relapsed with a 75% Ph1 positive karyotype associated with positive bcr. Subsequently, the patient died of refractory leukemia.
Ichikawa
S
S
Natsuyama
M
M
Okano
S
S
Hashida
T
T
Fukumochi
H
H
Matsumura
T
T
Fujita
K
K
Sugimoto
T
T
Imashuku
S
S
D002648:Child; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D012008:Recurrence