Fatal phenytoin-related toxic epidermal necrolysis: case report.
Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head injury. The typical course and current management of toxic epidermal necrolysis are reviewed, as are the indications for the prophylaxis of posttraumatic epilepsy.
Kelly
D F
DF
Department of Neurosurgery, George Washington University School of Medicine, Washington, District of Columbia.
Hope
D G
DG
D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000633:toxicity*; D013262:Stevens-Johnson Syndrome / Q000473:pathology*
D010672:Phenytoin