[Cerebral hemodynamics and functional prognosis in hydrocephalus].
The functional outcome of cerebral hemodynamics in the chronic stage of juvenile hydrocephalus was determined using single photon emission computed tomography (SPECT). Five patients including three with aqueductal stenosis, one with post-meningitic hydrocephalus, and one case with hydrocephalus having developed after repair of a huge occipital encephalocele. Early images of cerebral blood flow (CBF) were obtained 25 minutes after intravenous injection of 123-I-Iodoamphetamine (IMP), and late images were scanned 3 hours later. Cerebral blood volume (CBV) was also measured using 99mTc in three patients. Twenty cases with adult communicating hydrocephalus were also investigated from the point of view of shunt effectiveness. Although there was no remarkable change in the cerebrovascular bed in the juvenile cases, CBF of the remnant brain parenchyma was good irrespective of the degree of ventricular dilatation. There was a periventricular-reduced IMP uptake in each case, however it somehow matched the ventricular span. Functional outcome one to 23 years after the initial shunt operation was good in every case, despite multiple shunt revisions. Redistribution on late images had no bearing on clinical states. In adult cases, 8 patients with effective shunting demonstrated a relatively localized periventricular low perfusion, with preoperative increased cerebrospinal fluid (CSF) pressure. On the contrary, 12 patients with no improvement with or without shunting showed disproportionately widespread periventricular-reduced IMP uptake, despite low CSF pressure. The present study indicates that periventricular hemodynamics may play an important role in cerebral function compromised by hydrocephalus.(ABSTRACT TRUNCATED AT 250 WORDS)
Hirai
O
O
Department of Neurosurgery, Hamamatsu Rosai Hospital, Japan.
Nishikawa
M
M
Watanabe
S
S
Yamakawa
H
H
Kinoshita
Y
Y
Uno
A
A
Handa
H
H
D000328:Adult; D002552:Cerebral Ventricles / Q000098:blood supply; D015170:Cerebrospinal Fluid Pressure; D002557:Cerebrospinal Fluid Shunts; D002560:Cerebrovascular Circulation; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D007223:Infant; D008297:Male; D011379:Prognosis; D015899:Tomography, Emission-Computed, Single-Photon