[The effect of a one-time administration of phenobarbital and carbon tetrachloride on comuton activity in the rat liver].
Infusion of phenobarbital and CCl4 was found to induce comuton control of mitochondrial respiration in a liver of starved rats. Comuton regulation of liver mitochondria respiration can be activated either by increase in liver activity or by damage caused by CCl4. The comuton regulation is directly induced by disturbance of energetic homeostasis of liver cells.
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D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D002251:Carbon Tetrachloride; D010634:Phenobarbital
Vliianie odnokratnogo vvedeniia fenobarbitala i chetyrekhkhloristogo ugleroda na aktivnost' komutona v pecheni krysy.