Somatostatin secretion from isolated rat pancreatic islets.
Certain aspects of somatostatin secretion from isolated rat pancreatic islets are described. A considerable, but falling basal secretion of somatostatin was observed in the pre-incubation periods. Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose. The glucose effect on somatostatin secretion required a normoglycaemic pre-incubation level of 5.5 mmol l-1 glucose. Our results indicate that somatostatin secretion from isolated pancreatic islets is strongly dependent on the experimental conditions.
Vonen
B
B
Department of Medicine, University Hospital of Tromsø, Norway.
Florholmen
J
J
Giaever
A K
AK
Burhol
P
P
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology
D013004:Somatostatin; D002217:Carbachol; D013806:Theophylline; D005947:Glucose