title: Verrucous carcinoma: a possible viral pathogenesis.
abstract: Seventeen cases of verrucous carcinoma of the oral cavity were reviewed. It was found that cytologic features generally associated with viral modification were observed in 15 of these cases. This finding suggests that viruses may play some role in the pathogenesis of verrucous carcinoma. The hypothesis that an opportunistic, persistent virus may act in concert with frank carcinogens to promote the development of verrucous carcinoma is discussed.
authors.forename: E
authors.initials: E
authors.lastname: Eisenberg
authors.forename: B
authors.initials: B
authors.lastname: Rosenberg
authors.forename: D J
authors.initials: DJ
authors.lastname: Krutchkoff
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002291:Carcinoma, Papillary / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002472:Cell Transformation, Viral; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007633:Keratins; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure; D014412:Tumor Virus Infections / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D007633:Keratins