[Effect of radix Paeoniae rubra 801 on the induction of cardiac and hepatic microsomal carboxylesterases activities in male rats].
Cardiac and hepatic microsomal carboxylesterases (EC. 3.1.1.1, CEase) activities were showed by measuring the released P-nitrophenol resulting from hydrolysis of P-nitrophenylacetate. Induction effects of inducers, such as PB, DEX, CPIB and Radix Paeoniae Rubra 801 (RPR 801), Radix Polygoni Multiflori (RPM), Herba Artemisiae Scopariae (HAS) on cardiac and hepatic CEase activities were observed. In the study, RPR 801 and HAS just like PB, DEX, CPIB had the induction effect on hepatic CEase activity (P less than 0.05); the liver weight could be increased by PB, DEX and CPIB (P less than 0.05) and could not be affected by RPR 801 and HAS, RPR 801 just like DEX, CPIB had the induction effect on cardiac CEase activity (P less than 0.05). The results suggested that RPR 801 and HAS could promote the hydrolysis process in liver and help to excrete of toxic substance.
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D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006868:Hydrolysis; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats
D004365:Drugs, Chinese Herbal; D002265:Carboxylic Ester Hydrolases