The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers.
We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a greater maximum concentration with a similar peak time. The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, especially in the elderly.
Benvenuti
C
C
Medical Department, Pharmaceutical Development, Formenti, Milan.
Bottà
V
V
Broggini
M
M
Gambaro
V
V
Lodi
F
F
Valenti
M
M
D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D000704:Analysis of Variance; D001381:Azepines / Q000008:administration & dosage* / Q000097:blood; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
D001381:Azepines