title: Emergence of methicillin-resistant clones from cephamycin-resistant Staphylococcus aureus.
abstract: Staphylococcus aureus strains specifically resistant to cephamycin antibiotics have been found among recent clinical isolates. These strains formed penicillin-binding protein (PBP) 2' and became phenotypically resistant to methicillin after induction with cefoxitin. Other cephamycin-type antibiotics also induced methicillin-resistance, whereas non-cephamycin-type cephalosporins such as cefmenoxime and ceftizoxime did not do so. The clones that constitutively synthesized PBP 2' arose from the cephamycin-resistant strains at a frequency of 10(-5). They were indistinguishable from clinically isolated methicillin-resistant S. aureus (MRSA). Cephamycin-resistant S. aureus may be a source for emerging MRSA.
authors.affiliation: Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okonogi
authors.forename: Y
authors.initials: Y
authors.lastname: Noji
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: A
authors.initials: A
authors.lastname: Imada
authors.forename: T
authors.initials: T
authors.lastname: Yokota
mesh_terms: D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism; D002513:Cephamycins / Q000494:pharmacology*; D003470:Culture Media; D006602:Hexosyltransferases; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D010403:Penicillin Resistance; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013696:Temperature
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D002513:Cephamycins; D003470:Culture Media; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D008712:Methicillin