Rat kidney function related to tissue glutathione levels. Effects of different glutathione depletors.
1. Rat renal function was evaluated during acute depletion of glutathione (GSH) produced by different doses of diethyl-maleate (DEM) or buthionine-sulfoximine (BSO). 2. Similar alterations in renal function were observed when similar GSH levels were obtained independently of the GSH depletor employed. 3. These results confirm the relationship between GSH levels and renal function.
Torres
A M
AM
Farmacologia-Facultad de Ciencias Bioquimicas y Farmaceuticas, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad Nacional de Rosario, Argentina.
Rodriguez
J V
JV
Elias
M M
MM
D000818:Animals; D019328:Buthionine Sulfoximine; D004305:Dose-Response Relationship, Drug; D005721:Glutamate-Cysteine Ligase / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000378:metabolism / Q000502:physiology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D008298:Maleates; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005721:Glutamate-Cysteine Ligase; C014476:diethyl maleate; D005978:Glutathione