The relationship of panic disorder and its treatment outcome to 24-hour urinary MHPG levels.
Levels of 24-hour urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) were not markedly elevated in a group of 35 panic disorder patients when compared to healthy controls (mean = 2,430 micrograms/day vs. 2,130 micrograms/day). There was a weak association between elevated pretreatment levels of MHPG and a positive treatment response to alprazolam or diazepam. Alprazolam and diazepam may differ in their effects on MHPG.
Garvey
M
M
University of Iowa, College of Medicine, Iowa City.
Noyes
R
R
Cook
B
B
Tollefson
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000525:Alprazolam / Q000494:pharmacology; D001008:Anxiety Disorders / Q000188:drug therapy / Q000652:urine*; D003975:Diazepam / Q000494:pharmacology; D004311:Double-Blind Method; D005239:Fear; D006018:Glycols / Q000652:urine*; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D011897:Random Allocation
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D003975:Diazepam; D000525:Alprazolam