title: Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat.
abstract: The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can be extended to include also other injured neurons such as the cholinergic neurons, known to be severely affected in Alzheimer's disease.
authors.forename: A M
authors.initials: AM
authors.lastname: Janson
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
authors.forename: A
authors.initials: A
authors.lastname: Jansson
authors.forename: B
authors.initials: B
authors.lastname: Bjelke
authors.forename: E
authors.initials: E
authors.lastname: Sundström
authors.forename: K
authors.initials: K
authors.lastname: Andersson
authors.forename: A
authors.initials: A
authors.lastname: Härfstrand
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: C
authors.initials: C
authors.lastname: Owman
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009538:Nicotine / Q000627:therapeutic use*; D051381:Rats; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009538:Nicotine; D004298:Dopamine