title: Twenty-five loci form a continuous linkage map of markers for human chromosome 7.
abstract: We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease.
authors.affiliation: Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: G M
authors.initials: GM
authors.lastname: Lathrop
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Leppert
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Farrall
authors.forename: L C
authors.initials: LC
authors.lastname: Tsui
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
authors.forename: R
authors.initials: R
authors.lastname: White
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003434:Crossing Over, Genetic; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers