title: Observations on Indian node-negative breast cancer patients: a multivariate analysis.
abstract: The modern treatment of breast cancer has evolved over the past 100 years based on clinical observations. Therapeutic principles, from the choice of surgical procedure to the management of disseminated disease, have also changed. The axillary tumour burden, that is, the number of histologically positive nodes (N+) plays an important role as a prognostic factor. However, in histologically Negative nodes (N-), it is necessary to discriminate individuals at high risk despite negative nodes. This presentation analyses retrospectively the prognostic factors for long-term failures in N- patients. These prognostic factors need to be studied in detail, and controlled clinical trials should be carried out to detect high risk N- patients and consider them for adjuvant chemotherapy.
authors.affiliation: Tata Memorial Hospital, Bombay, India.
authors.forename: J J
authors.initials: JJ
authors.lastname: Vyas
authors.forename: P B
authors.initials: PB
authors.lastname: Desai
authors.forename: M B
authors.initials: MB
authors.lastname: Sampat
authors.forename: S R
authors.initials: SR
authors.lastname: Shinde
authors.forename: D N
authors.initials: DN
authors.lastname: Rao
authors.forename: S
authors.initials: S
authors.lastname: Sarkar
authors.forename: R
authors.initials: R
authors.lastname: Badwe
authors.forename: J
authors.initials: J
authors.lastname: Tiwari
authors.forename: A
authors.initials: A
authors.lastname: Koppikar
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008198:Lymph Nodes / Q000473:pathology*; D015411:Mastectomy, Modified Radical; D015409:Mastectomy, Radical; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents