title: Bioavailability of intranasal metoclopramide.
abstract: After intranasal administration of metoclopramide, (5 mg in 0.5 ml sterile water) the maximum plasma concentration of 13.5 +/- 7.3 (mean +/- s.d.) ng ml-1 was achieved. Absolute bioavailability was 50.5 +/- 29.5%, 110 +/- 41 min later. We conclude that the intranasal route does not allow rapid absorption of the drug and is not associated with greater bioavailability than the oral route.
authors.affiliation: Department of Clinical Pharmacology, University of Wales College of Medicine, Liandough Hospital, South Glamorgan.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ward
authors.forename: D C
authors.initials: DC
authors.lastname: Buss
authors.forename: J
authors.initials: J
authors.lastname: Ellershaw
authors.forename: A
authors.initials: A
authors.lastname: Nash
authors.forename: P A
authors.initials: PA
authors.lastname: Routledge
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D008787:Metoclopramide