Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients.
Using a full length cystatin C cDNA probe and the Alu I restriction enzyme a total of 33 patients with senile dementia, Alzheimer type and 31 Down's syndrome patients have been investigated for the presence of the 630 bp Alu I restriction fragment length polymorphism in the cystatin C gene detected in Icelandic patients with hereditary cystatin C amyloid angiopathy. Results showed that all the patients had normal cystatin C fragment length of 600 bp.
Palsdottir
A
A
Blood Bank, National Hospital, Reykjavik.
Thorsteinsson
L
L
Jonsdottir
S
S
Arnason
A
A
Snaedal
J
J
Magnusson
T
T
Snorrason
E
E
Ingibergsdottir
R
R
Abrahamson
M
M
Olafsson
I
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis*; D015342:DNA Probes; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007055:Iceland; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D015342:DNA Probes; D005819:Genetic Markers