title: MAP, an expert system for multiple pairwise linkage analysis.
abstract: The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve the trial order, and three procedures for quality control to detect mistyping. This approach is compared with multipoint analysis under null interference, which substantially overestimates map length and cannot incorporate a variety of data.
authors.affiliation: Department of Community Medicine, University of Southampton.
authors.forename: N E
authors.initials: NE
authors.lastname: Morton
authors.forename: V
authors.initials: V
authors.lastname: Andrews
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping; D005103:Expert Systems; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011995:Recombination, Genetic