title: Vasoactive intestinal polypeptide identified in the thoracic dorsal root ganglia of the cat.
abstract: Neurons which exhibited vasoactive intestinal polypeptide (VIP) immunoreactivity were identified with immunohistochemical techniques in the cat thoracic dorsal root ganglia (DRG, T8-T11) injected with colchicine 2 days prior to sacrifice. VIP-positive cells (5-40 cells per section) were small to medium size ranging from 14-41 micron in diameter. VIP-immunoreactivity was weaker in the thoracic DRG exposed to colchicine by topical administration. The neuropeptide could not be detected in the thoracic DRG (T1-T13) in the absence of colchicine. VIP-immunoreactivity was also identified in the superficial laminae (I and II) of the thoracic spinal cord. The findings indicate that VIP in afferent pathways in the cat is distributed more extensively than previously reported and is not restricted only to the lower lumbar and sacral levels of the spinal cord.
authors.forename: D C
authors.initials: DC
authors.lastname: Kuo
authors.forename: M
authors.initials: M
authors.lastname: Kawatani
authors.forename: W C
authors.initials: WC
authors.lastname: de Groat
mesh_terms: D000818:Animals; D002415:Cats; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D013004:Somatostatin / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin