Bronchial and basophil reaction to polymyxin B in asthmatic patients.
The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulation was noted in 17 patients, but in none of 10 healthy controls. There was close relationship between basophil "releasability" to polymyxin B and bronchial reactivity to inhaled polymyxin B. These findings support the hypothesis.
Górski
P
P
Rozniecki
J
J
Kuźmińska
B
B
Grzegorczyk
J
J
D000402:Airway Obstruction / Q000139:chemically induced; D001249:Asthma / Q000503:physiopathology*; D001491:Basophils / Q000187:drug effects*; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000139:chemically induced; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D011112:Polymyxin B / Q000009:adverse effects / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*
D011113:Polymyxins; D011112:Polymyxin B