Ribavirin inhibits proliferation of bovine respiratory syncytial virus in vitro.
Bovine respiratory syncytial virus (BRSV) is an important pathogen in bovine respiratory diseases in the United States. Proliferation of the disease can reach epidemic proportions with mortality reaching as high as 20%. In vitro work shown here suggests that the antiviral compound Ribavirin will be effective in the treatment of infected animals. Treatment at three dose levels with Ribavirin have shown significant inhibition of BRSV proliferation. Bovine turbinate cells were host cells for this study. Tissue culture specimens, infected and noninfected, were carried for 10 days. Presence of BRSV was verified with the use of monoclonal antibody. In addition, the infection with BRSV and consequential treatment with Ribavirin of calves demonstrated a noticeable reduction in viral symptom but no apparent systemic reaction to drug therapy.
Bartzatt
R
R
Veterinary Basic Sciences, University of Nebraska, Lincoln 68583.
Anderson
G A
GA
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000254:growth & development; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
D012263:Ribonucleosides; D012254:Ribavirin