Effect of 5-azacytidine (5-azaC) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE).
Experiments were carried out using human lymphocytes from a male donor in order to test the action of 5-azaC treatment on the induction of SCE and chromatid aberrations. The 5-azaC was found to increase the frequency of both baseline and MMC-induced SCEs. Using the same 5-azaC treatment conditions it was found that the frequency of X-ray-induced CA did not increase.
Lavia
P
P
Ferraro
M
M
Micheli
A
A
Olivieri
G
G
D001374:Azacitidine / Q000633:toxicity*; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D004357:Drug Synergism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects; D014965:X-Rays
D008937:Mitomycins; D016685:Mitomycin; D001374:Azacitidine