alpha 1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium.
The determination of alpha 1-microglobulin (alpha 1-m) in urine was compared with that of beta 2-microglobulin (beta 2-m) for the detection of renal tubular dysfunctions caused by exposure to cadmium. alpha 1-m In urine is stable down to pH 4.5, whereas beta 2-m degrades below pH 5.5. The relationship between the urinary pH and alpha 1-m or beta 2-m in urine showed that alpha 1-m was independent of urinary pH, whereas beta 2-m-concentration decreased as urinary pH fell to a pH level below 6. Without a pH effect, alpha 1-m was highly correlated with beta 2-m in urine (N = 174, r = 0.96) from Cd-polluted subjects with renal dysfunctions. Due to the greater stability of alpha 1-m in urine, alpha 1-m seemed to be more advantageous than beta 2-m for the detection of renal tubular dysfunctions caused by Cd.
Kido
T
T
Honda
R
R
Yamada
Y
Y
Tsuritani
I
I
Ishizaki
M
M
Nogawa
K
K
D000328:Adult; D000510:Alpha-Globulins / Q000652:urine*; D002105:Cadmium Poisoning / Q000175:diagnosis* / Q000652:urine; D003404:Creatinine / Q000652:urine; D004781:Environmental Exposure; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000652:urine; D007684:Kidney Tubules / Q000503:physiopathology*; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine
D000510:Alpha-Globulins; C016001:alpha-1-microglobulin; D001613:beta 2-Microglobulin; D003404:Creatinine