Intracerebroventricular (ICV) clonidine produces an antianalgesic effect through spinal dynorphin A(1-17) mediation.
Fujimoto
J M
JM
Research Service, VA Medical Center, Milwaukee, WI.
Arts
K S
KS
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004399:Dynorphins / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D004399:Dynorphins; D009020:Morphine; D003000:Clonidine