Neurotensin-like immunoreactivity in cerebrospinal fluid of patients with schizophrenia, depression, anorexia nervosa-bulimia, and premenstrual syndrome.
Neurotensin (NT) concentrations in cerebrospinal fluid (CSF) were measured by a sensitive and specific radioimmunoassay in psychiatric patients and age- and sex-matched normal controls. No increase in CSF NT concentrations was observed after antipsychotic drug treatment. CSF NT concentrations were significantly lower in one group of schizophrenic subjects. NT concentrations were unaltered in patients with depression, anorexia/bulimia, or premenstrual syndrome, and no rostral-caudal gradient for NT in CSF was evident. NT concentrations were not related to age or sex, and probenecid treatment did not alter CSF NT concentrations. Finally CSF NT concentrations were unaltered in paranoid schizophrenic subjects. These findings confirm and extend previous studies of CSF NT that showed certain patients with schizophrenia, nonparanoid type, have reduced CSF concentrations of this tridecapeptide.
Nemeroff
C B
CB
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Bissette
G
G
Widerlov
E
E
Beckmann
H
H
Gerner
R
R
Manberg
P J
PJ
Lindstrom
L
L
Prange
A J
AJ
Gattaz
W F
WF
D000328:Adult; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D002032:Bulimia / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D002853:Chromatography, Liquid; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D009496:Neurotensin / Q000134:cerebrospinal fluid* / Q000276:immunology; D011293:Premenstrual Syndrome / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000188:drug therapy
D014150:Antipsychotic Agents; D009496:Neurotensin