title: Acute necrotising myopathy associated with amiodarone therapy.
abstract: We report a patient who developed an acute painful proximal myopathy associated with the use of amiodarone. The temporal course, the presence of amiodarone related hypothyroidism and neuropathy, as well as the patient's improvement on drug withdrawal were consistent with a drug reaction. Muscle biopsy demonstrated an acute necrotising myopathy. The mechanism for this reaction is unclear.
authors.affiliation: Repatriation General Hospital, Concord, NSW, Australia.
authors.forename: P D
authors.initials: PD
authors.lastname: Clouston
authors.forename: P E
authors.initials: PE
authors.lastname: Donnelly
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced; D008297:Male; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis
chemical_list: D000638:Amiodarone