Comparison of the effects of peritoneal and spleen cells of syngeneic or allogeneic origin on the take of transplantable murine tumours.
We compared the effects of various potential effector cells of syngeneic or allogeneic origin on the take of a spontaneous adenocarcinoma (SP4) and Lewis lung (LL) carcinoma. As reported earlier, syngeneic resident (non-activated) peritoneal cells (PC) did not inhibit the take of these tumours. On the contrary, transfer of resident PC from allogeneic donors suppressed the tumour take. Syngeneic and allogeneic PC activated by poly I:C or by a combination of indomethacin, poly I:C and Syncumar ("combined treatment") inhibited the tumour take to a similar extent. Syngeneic spleen cells (from untreated mice or from donors underwent "combined treatment") did not inhibit the take of Lewis lung tumour. Transfer of activated allogeneic spleen cells resulted in a stronger inhibition of tumour take than the transfer of resident allogeneic spleen cells.
Karczag
E
E
Microbiological Research Group of the National Institute of Hygiene, Budapest, Hungary.
Minárovits
J
J
Földes
I
I
D000074:Acenocoumarol / Q000494:pharmacology; D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D002277:Carcinoma / Q000276:immunology*; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000166:cytology*; D011070:Poly I-C / Q000494:pharmacology; D013154:Spleen / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous / Q000276:immunology; D014185:Transplantation, Isogeneic / Q000276:immunology
D000074:Acenocoumarol; D011070:Poly I-C; D007213:Indomethacin