The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21.
Utilizing the backcross C57BL/6 wv/wv x (C57BL/6 wv/wv x MOLD/Rk), the mouse neurological mutation weaver (wv) was mapped less than 1 cM proximal to Ets-2 and Mx on mouse chromosome 16 (0.96 +/- 0.1% recombination). This region is known to include eight genes that are found on human chromosome 21 (HSA 21) and appears to be highly conserved between the two species. We therefore predict that the normal human homolog of wv will be located on HSA 21 and would be in dosage imbalance in individuals with Down syndrome.
Reeves
R H
RH
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Crowley
M R
MR
Lorenzon
N
N
Pavan
W J
WJ
Smeyne
R J
RJ
Goldowitz
D
D
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002875:Chromosomes; D002891:Chromosomes, Human, Pair 21; D003433:Crosses, Genetic; D004586:Electrophoresis; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid