[Morphology and pathogenesis of changes in the lungs during drug-induced anaphylactic shock in humans].
The paper presents the results from examinations of morphological changes in the lung of 51 persons who died from drug-induced anaphylactic shock at the age of 6 months to 67 years. The patients died several minutes to 7-10 days following drug administration. The causes of the shock were administrations of antibiotics, novocain (procaine hydrochloride), glucose, radiopaque agents, plasma-substituting solutions, protein hydrolysates, and other substances. Forty-nine persons died after parenteral drug administration. The most frequent concurrent conditions were gastrointestinal and respiratory diseases and pregnancy. A clinical and morphological analysis of the material enabled the authors to single out 6 types of drug-induced anaphylactic shock: asphyxial, bronchospasmic, hemodynamic, cerebral, abdominal and a variant with prevalent pulmonary edema. Typical characteristics of pulmonary alterations are described in each type of the shock.
Shkutin
A E
AE
Naresheva
K A
KA
Donchenko
V S
VS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D001237:Asphyxia / Q000139:chemically induced; D001921:Brain / Q000187:drug effects; D001986:Bronchial Spasm / Q000139:chemically induced; D002648:Child; D004342:Drug Hypersensitivity / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000139:chemically induced
Morfologiia i patogenez izmeneniĭ legkikh pri lekarstvennom anafilakticheskom shoke u cheloveka.