Relevance of kinetic and metabolic data to the interpretation of toxicological findings.
Metabolic and kinetic data on pesticides are now becoming an important part of the toxicological dossier required for product registration. In this paper the approach by one agrochemical company to generating such data is discussed. Metabolic data for the acaricide clofentezine are presented to illustrate why such data should be regarded as not only an important registration requirement, but also as integral to understanding the toxicological profile of pesticides.
Somerville
L
L
Schering Agrochemicals, Ltd., Essex, UK.
Challis
I R
IR
Needham
D
D
D000818:Animals; D002417:Cattle; D002722:Chlorobenzenes / Q000633:toxicity; D004285:Dogs; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010575:Pesticides / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D014018:Tissue Distribution
D002722:Chlorobenzenes; D010575:Pesticides; C062106:clofentezine