title: Co-localization of adrenergic receptors and vitamin-D-dependent calcium-binding protein (calbindin) in the dopaminergic amacrine cells of the rat retina.
abstract: Using antisera against tyrosine hydroxylase (TH) and purified beta 2-adrenergic receptors (beta 2-AdR), we found that TH- and AdR-like immunoreactivities coexisted in large amacrine cells. These findings indicated an association between dopamine-containing amacrine cells and adrenergic amacrine cells. The present study also showed that amacrine cells with TH-like immunoreactivity have vitamin-D-dependent calcium-binding protein (calbindin, 27,000 kDa)-like immunoreactivity as well, suggesting that calbindin plays an important postsynaptic role in dopaminergic amacrine cells.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Ishimoto
authors.forename: H
authors.initials: H
authors.lastname: Kiyama
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: S
authors.initials: S
authors.lastname: Shiosaka
authors.forename: C C
authors.initials: CC
authors.lastname: Malbon
authors.forename: M
authors.initials: M
authors.lastname: Nakauchi
authors.forename: P C
authors.initials: PC
authors.lastname: Emson
authors.forename: R
authors.initials: R
authors.lastname: Manabe
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D000818:Animals; D064026:Calbindins; D004298:Dopamine / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D064026:Calbindins; D011943:Receptors, Adrenergic, beta; D064030:S100 Calcium Binding Protein G; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine