title: Effect of anthracycline antibiotics on the reconstituted mitochondrial tricarboxylate carrier.
abstract: The effect of anthracycline antibiotics on the activity of the partially purified and reconstituted tricarboxylate carrier system of the rat liver mitochondria was studied. It was found that the citrate/citrate exchange activity is inhibited by Br-daunomycin and with less potency by doxorubicin, daunomycin, epirubicin and idarubicin. The inhibition of the citrate transport activity is concentration and time-dependent. Cardiolipin protects against the inhibition by Br-daunomycin and the reconstituted citrate transport activity depends upon the ratio of cardiolipin/Br-daunomycin.
authors.affiliation: Department of Pharmaco-Biology, University of Bari, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Stipani
authors.forename: M I
authors.initials: MI
authors.lastname: Capalbo
authors.forename: V
authors.initials: V
authors.lastname: Zara
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002352:Carrier Proteins / Q000378:metabolism*; D002951:Citrates / Q000378:metabolism; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D015251:Epirubicin / Q000494:pharmacology; D015255:Idarubicin / Q000494:pharmacology; D007700:Kinetics; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats
chemical_list: D000903:Antibiotics, Antineoplastic; D002352:Carrier Proteins; D002951:Citrates; C020723:citrate-binding transport protein; D015251:Epirubicin; C059433:14-bromodaunorubicin; D004317:Doxorubicin; D015255:Idarubicin; D003630:Daunorubicin