Multicentric angiofollicular lymph node hyperplasia associated with a solitary osteolytic costal IgG lambda myeloma. POEMS syndrome in a South American (Paraguayan) patient.
We report the case of a 46-year-old woman presenting with a disorder characterized by the association of multicentric Castleman's disease, organomegaly, a solitary IgA lambda myeloma with lytic bone lesions but no serum monoclonal peak, peripheral neuropathy and skin changes. This unusual association resulted in an incomplete form of that peculiar multisystem syndrome described under a variety of names: Crow-Fukase syndrome, Shimpo's syndrome, Takatsuki's syndrome, PEP syndrome or POEMS syndrome. The possible relationship between localized and multicentric Castleman's disease with myeloma or extramedullary plasmacytoma on one hand and on the other hand with polyneuropathy and the other symptoms of the POEMS syndrome is discussed.
Rolon
P G
PG
Service Central d'Anatomie et Cytologie Pathologiques, Paris, France.
Audouin
J
J
Diebold
J
J
Rolon
P A
PA
González
A
A
D001859:Bone Neoplasms / Q000150:complications*; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications*; D012272:Ribs; D013577:Syndrome
D007074:Immunoglobulin G