Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations.
The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind, latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.
Tedeschi
G
G
Institute of Neurological Sciences, First Faculty of Medicine, University of Naples, Italy.
Casucci
G
G
Allocca
S
S
Riva
R
R
Di Costanzo
A
A
Quattrone
A
A
Baruzzi
A
A
Bonavita
V
V
D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology*; D003201:Computers; D005133:Eye Movements / Q000187:drug effects*; D006801:Humans; D008297:Male; D012438:Saccades / Q000187:drug effects*
D002220:Carbamazepine