Blood coagulation changes in rats poisoned with methylmercuric chloride (MeHg).
The effects of methylmercuric chloride on the coagulability of blood were studied in rats. The administration of a single dose (17.9 mg Hg/kg) and a repeated dose (5 X 8 mg Hg/kg/day) of this compound resulted in hypercoagulation. The reduction of the clotting time, the increase of fibrinogen level in plasma and changes characteristic of hypercoagulation in the thromboelastographic parameters were observed. Simultaneously, signs of impaired activity of blood platelets: decreased aggregation velocity and clot retraction as well as prolongation of the bleeding time were noticed.
Kostka
B
B
Department of Biochemistry, Medical Academy, Lódź, Poland.
Michalska
M
M
Krajewska
U
U
Wierzbicki
R
R
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008628:Mercury / Q000097:blood; D008767:Methylmercury Compounds / Q000506:poisoning*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D013916:Thrombelastography
D008767:Methylmercury Compounds; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D008628:Mercury