[Synthesis and antitumor action of N,N-di(2-chlorethyl)-hydrazines of alpha-aminocarboxylic acid antimetabolites].
The N,N-di(2-chlorethyl)hydrazides of the following alpha-aminocarboxylic acid antimetabolites: methioninsulphoxide, ethionine, 2-, 3- and 4-fluorophenylalanine, 4-nitrophenylalanine and 2,2-dimethyl-thiazolidine-4-carboxylic acid were synthesized. Preliminary studies of the activity on experimental tumour models were carried out. It was shown that these compounds have a high antitumour effect (80-100%) on sarcoma Yoshida and carcinosarcoma Walker.
Zakhariev
S
S
Institut für Molekularbiologie der Bulgarischen Akademie der Wissenschaften Chemisch-technologische Hochschule, Sofia, VR Bulgarien.
Golovinsky
E
E
Stoev
S
S
Maneva
L
L
Aleksiev
B
B
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000963:Antimetabolites / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012517:Sarcoma, Yoshida / Q000188:drug therapy
D000596:Amino Acids; D000963:Antimetabolites; D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds
Synthese und geschwulsthemmende Wirkung von N,N-Di(2-chlorethyl)-hydrazinen der alpha-Aminocarbonsäureantimetabolite.