Successful generation of cytotoxic T lymphocytes specific for self immunoglobulin-determinants on B lymphocytes.
Cytotoxic T lymphocytes (CTL) specific for self immunoglobulin (Ig) determinants on B lymphocytes were successfully generated. These CTL were induced with stimulator B hybridoma cells bearing self Ig determinants in responders compatible with the stimulators in H-2 antigens but disparate in minor H antigens. Their specificities were directed toward the idiotype and probably the allotype structures of Ig receptors on stimulator B cells. However, no CTL specific for Ig structures other than the idiotype and the allotype were detected. These data indicate the presence of specific precursor CTL for self B cell clones and suggest the possible development and function of these CTL in certain situations.
Dohi
Y
Y
Higasa
M
M
Nishimura
M
M
Hirayama
A
A
Takagaki
Y
Y
Yamada
K
K
Inoue
K
K
Shinka
S
S
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001667:Binding, Competitive; D003433:Crosses, Genetic; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology*; D006825:Hybridomas / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D007130:Immunoglobulin Idiotypes