title: Genetic correction of hereditary disease.
abstract: Several hereditary disorders may be potentially correctable by the introduction and incorporation of the normal gene into human tissues using a variety of systems. Although technical issues surrounding integration, stable expression and potential insertional mutagenesis to the treated cells has not yet been fully resolved, enough scientific progress has already been made to consider somatic cell gene therapy acceptable from both the scientific and ethical viewpoints. Tissue-specific stem cell and embryonic stem cell transplantation will allow therapy earlier in the developing embryo. As technical problems are eliminated, these procedures will become morally permissible, as they will allow the correction of devastating hereditary disease.
authors.affiliation: Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Mich.
authors.forename: M P
authors.initials: MP
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Drugan
authors.forename: O J
authors.initials: OJ
authors.lastname: Miller
authors.forename: M I
authors.initials: MI
authors.lastname: Evans
mesh_terms: D004992:Ethics, Medical; D005053:Eugenics; D005260:Female; D005315:Fetal Diseases / Q000628:therapy*; D030342:Genetic Diseases, Inborn / Q000196:embryology / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011247:Pregnancy; D033581:Stem Cell Transplantation