Amiloride does not block taste transduction in the mouse (Slc:ICR).
1. The receptor potential of the mouse taste cell was recorded with an intracellular microelectrode while taste stimuli were applied to the tongue surface of the anesthetized mouse. 2. A membrane depolarization accompanied by an increase in membrane resistance was observed after a sucrose stimulus. 3. A sodium-chloride stimulus initiated a membrane depolarization accompanied by a decrease in membrane resistance. 4. Amiloride elicits a depolarization of the membrane and is accompanied by an increase in membrane resistance. 5. Pre-adapting the tongue to amiloride, which is known as a potent sodium channel blocker, did not alter the responses to sodium-chloride and other taste stimuli.
Tonosaki
K
K
Department of Oral Physiology, School of Dentistry, Asahi University, Gifu, Japan.
Funakoshi
M
M
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D004594:Electrophysiology; D008297:Male; D051379:Mice; D012965:Sodium Chloride; D013395:Sucrose; D013650:Taste Buds / Q000187:drug effects* / Q000502:physiology; D014059:Tongue / Q000166:cytology* / Q000187:drug effects
D012965:Sodium Chloride; D013395:Sucrose; D000584:Amiloride