Intracellular injection of cAMP and cGMP into snail neurones induces an increase in Na+-conductance.
Injection of cAMP and more rarely cGMP into the neurones of the snail Helix pomatia induces an increase in membrane conductance, membrane depolarization and excitation. The effect is theophylline-dependent and has a reversal potential near -10mV.
Solntseva
E I
EI
Bezrukova
L V
LV
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004553:Electric Conductivity; D005724:Ganglia / Q000502:physiology; D006372:Helix, Snails; D007473:Ion Channels / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000502:physiology*
D007473:Ion Channels; D012964:Sodium; D000242:Cyclic AMP; D006152:Cyclic GMP