Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
Debrisoquine and S-mephenytoin hydroxylation phenotyping tests were performed in 9 patients before and during treatment with diazepam at a daily dose of 10 or 15 mg. There was no change in either the debrisoquine/4-hydroxydebrisoquine ratio or the ratio of S/R mephenytoin in urine. The hydroxylation of these two test drugs is apparently not inhibited by administration of therapeutic doses of diazepam.
Spina
E
E
Institute of Pharmacology, University of Messina, Italy.
Buemi
A L
AL
Sanz
E
E
Bertilsson
L
L
D000328:Adult; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D006827:Hydantoins / Q000378:metabolism*; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008617:Mephenytoin / Q000378:metabolism*; D008875:Middle Aged; D010641:Phenotype
D006827:Hydantoins; D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003975:Diazepam; D008617:Mephenytoin; D003647:Debrisoquin