[Effect of natural neurotensin and its analog on gastric secretion and levels of various peptides in dog blood].
I.v. administration of neurotensin and its analogue DTch1I--neurotensin considerably decreased stomach secretion induced with pentagastrin but did not suppress stomach secretion induced with histamine, neither a microapplication of 10 micrograms in 3 microliter of neurotensin affected the secretion whereas the dose 50 micrograms in 3 microliter decreased both volume and acidity of the juice. I.v. administration of neurozensin increased the gastrin, neurotensin and the substance P contents in the dog blood. Microapplication of neurotensin to the globus pallidus with simultaneous i.v. administration of histamine increased the level of the serum gastrin.
Barashkova
G M
GM
Ardemasova
Z A
ZA
D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006632:Histamine / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000097:blood*; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013373:Substance P / Q000097:blood
D005755:Gastrins; D009419:Nerve Tissue Proteins; D013373:Substance P; D009496:Neurotensin; C024309:neurotensin, Trp(11)-; D006632:Histamine; D010418:Pentagastrin
Vliianie prirodnogo neĭrotenzina i ego analoga na sekretsiiu zheludkai soderzhanie nekotorykh peptidov v krovi sobak.