[The effect of somatotropin on the healing of skin wounds under hypoxic conditions].
Using cytological, histological, histochemical and histoautoradiographic methods, it was demonstrated that skin recovery in the hypoxic state can be stimulated by somatotropin (STH). STH was shown to stimulate wound healing at every stage: cell migration to the injured area was accelerated, microbial phagocytosis and proliferation of epithelial and connective tissue cells were activated. This led to faster granulation and epithelialization of the wounded surface. The de novo formed epithelium showed a higher activity of succinate dehydrogenase and the granulation tissue - a higher activity of alkaline phosphatase. The hormone treatment reduced destruction of cell elements, newly formed vessels and fibrous structures of the wound which was caused by the hypoxic effect.
Khomullo
G V
GV
Lotova
V I
VI
Cherniaev
A N
AN
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D013006:Growth Hormone
Vliianie somatotropina na zazhivlenie ran kozhi v usloviiakh gipoksii.