Local immunoglobulin synthesis and blood-brain barrier assessment in subacute sclerosing panencephalitis.
The immunoglobulin synthesis within the central nervous system and the blood-brain barrier (BBB) function were evaluated in 6 patients with subacute sclerosing panencephalitis (SSPE) using the IgG index and a graphic method based on serum/CSF albumin, alpha 2-macroglobulin, and IgG quotients. A strong local production of IgG was documented by both methods in all 6 cases of SSPE. Concerning the graphic analysis, the decrease in the serum/CSF alpha 2-macroglobulin ratio disclosed BBB dysfunction in 2 cases of SSPE, suggesting, in the absence of the serum/CSF albumin quotient abnormalities, that a homeostatic mechanism for CSF proteins can cause changes in the CSF protein profile.
Silva
C A
CA
Rio
M E
ME
Cruz
C
C
D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D002648:Child; D006801:Humans; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D008297:Male; D012709:Serum Albumin / Q000134:cerebrospinal fluid; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000134:cerebrospinal fluid
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D012709:Serum Albumin; D000511:alpha-Macroglobulins