[Mechanisms of neovasculogenesis and its regulation in the adult organism].
Under regeneration of organs, wound healing, tumour growth, inflammatory processes, under many compensatory and adaptive reactions in the organism of mature persons and animals, an inevitable formation of new blood vessels (neovasculogenesis) takes place. Modern notions on mechanisms of neovasculogenesis are based on the fact that new formation of vessels in a mature organism includes processes of migration and replication of endothelial cells according to the principle: "endothelium from endothelium". The literature data on neovasculogenesis in the mature organism are summarized and compared with the authors' investigations. Characterization of new blood vessels growth is presented; ultrastructural organization of endotheliocytes in growing capillaries, formation of barrier-transport properties in the newly formed vessels, role of inductors and inhibitors of neovasculogenesis in creation of new vascular formations are considered.
Gurina
O Iu
OIu
Kupriianov
V V
VV
Mironov
A A
AA
Mironov
V A
VA
D000818:Animals; D001160:Arterioles / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D002199:Capillary Permeability; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D002630:Chemotactic Factors / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004727:Endothelium / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008833:Microcirculation / Q000648:ultrastructure; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D014699:Venules / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology
D002630:Chemotactic Factors; D004247:DNA
Mekhanizmy neovaskulogeneza i ego reguliatsiia vo vzroslom organizme.