The woolly monkey (Lagothrix lagothricha): a possible model for human hypertension research.
The anatomical-pathological findings of 15 woolly monkeys were comparable with those described in man with essential benign or malignant hypertension. Kidneys revealed arterio- and arteriolosclerosis or an onion peel-like proliferation, in some cases necrotizing endarteritis. Obesity due to restricted physical activity, unnatural feeding, and psychical and physical stress could have contributed to the development of this condition. Further, high vulnerability of the genus woolly monkey is postulated. Thus, essential hypertension of woolly monkeys appears to be a multifactorial disease.
Müller
M
M
Heldstab
A
A
Luginbühl
H
H
D000818:Animals; D001158:Arteries / Q000473:pathology; D002427:Cebidae; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000473:pathology*; D007668:Kidney / Q000473:pathology; D008297:Male