Gastroprotective activity of ginger zingiber officinale rosc., in albino rats.
The cytoprotective and gastric anti-ulcer studies of ginger have been carried out in albino rats. Cytodestruction was produced by 80% ethanol, 0.6M HC1, 0.2M NaOH and 25% NaCl. Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique. The results of this study demonstrate that the extract in the dose of 500 mg/kg orally exert highly significant cytoprotection against 80% ethanol, 0.6M HC1, 0.2M NaOH and 25% NaCl induced gastric lesions. The extract also prevented the occurrence of gastric ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) and hypothermic restraint stress. These observations suggest cytoprotective and anti-ulcerogenic effect of the ginger.
al-Yahya
M A
MA
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Rafatullah
S
S
Mossa
J S
JS
Ageel
A M
AM
Parmar
N S
NS
Tariq
M
M
D000818:Animals; D001241:Aspirin / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006851:Hydrochloric Acid / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000009:adverse effects; D012965:Sodium Chloride / Q000009:adverse effects; D012972:Sodium Hydroxide / Q000009:adverse effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology*; D013312:Stress, Physiological
D004365:Drugs, Chinese Herbal; D000431:Ethanol; D012965:Sodium Chloride; D012972:Sodium Hydroxide; D012110:Reserpine; D006851:Hydrochloric Acid; D001241:Aspirin; D007213:Indomethacin