[Experimental study on the antigoiter effect of high casein nutrition].
In this experiment, goiter was successfully induced in rat with MMI, and the antigoiter effect of 25% and 50% casein diet was observed. The results showed that the diet with 50% casein is more effective than that with 25% casein in counteracting MMI and preventing goiter in rat. The antigoiter mechanisms of high protein nutrition might be as follows: Protecting the mechanism of thyroid iodine transportation through the follicular cell, and therefore accelerating thyroid iodine metabolism; Relieving thyroid peroxidase (TPO) from the inhibitive effect of MMI and facilitating thyroid hormone synthesis; Coordinating the function of hypothalamus-pituitary-TSH-thyroid axis and protecting the wholeness of thyroid cell and thus avoiding the occurrence of pathological changes.
Yu
B
B
D000818:Animals; D002364:Caseins / Q000627:therapeutic use*; D005260:Female; D006042:Goiter / Q000139:chemically induced / Q000178:diet therapy / Q000517:prevention & control*; D007455:Iodine / Q000378:metabolism; D008713:Methimazole; D051381:Rats; D011919:Rats, Inbred Strains
D002364:Caseins; D008713:Methimazole; D007455:Iodine