Suppression of murine IgE responses with amino acid polymer/allergen conjugates. II. Suppressive activities in adjuvant-induced IgE responses.
Treatment with conjugates of polysarcosine and grass pollen allergen extracts efficiently suppressed the induction of IgE responses in mice. The suppressive activity was shown to be allergen-specific and required covalent linking of the polysarcosine. Inhibitory effects could be overcome by booster injections of native allergen when these were given 3-4 weeks after treatment with conjugates. Administration of conjugates had only marginal effects on established IgE responses. The variance of these results with those of other studies on IgE suppression and the suitability of murine models for investigating reaginic antibody suppression are discussed.
Wheeler
A W
AW
Henderson
D C
DC
Garman
A J
AJ
Moran
D M
DM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D007108:Immune Tolerance; D007117:Immunization, Secondary; D007073:Immunoglobulin E / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D012521:Sarcosine / Q000031:analogs & derivatives* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000485:Allergens; D010455:Peptides; C015475:polysarcosine; D007073:Immunoglobulin E; D012521:Sarcosine