[Chemoradiation treatment of patients with aggressive non-Hodgkin's lymphomas in stages I to II of the disease].
Altogether 91 patients underwent treatment. Polychemotherapy (COP, ACOP) and radiotherapy were provided to 43 patients. Of these, 26 patients were irradiated locally and 17 were subjected to extensive radiation. Radiotherapy was given to 48 patients. Of these, 36 patients were subjected to irradiation of the local lesions whereas 12 underwent extensive radiation. Complete remissions were attained in 81 and 75% of the patients, respectively. The 5-year survival amounted to 65 and 34% (p less than 0.05), the 5-year survival without any relapses to 55 and 25% (p less than 0.01). In the IA stage, the 5-year survival was 89 and 44% (p less than 0.05) and the 5-year survival without relapses 63 and 13% (p less than 0.05). In the IIA stage, a statistically significant increase of the 5-year survival was also reached. No material differences could be seen in the results of the treatment depending on the scope of radiation. Drug + radiation treatment turned out most effective for the local stages of aggressive non-Hodgkin's lymphomas.
Sotnikov
V M
VM
Polianskaia
A M
AM
Pan'shin
G A
GA
Ingberman
Ia Kh
IaKh
Kaplanskaia
I B
IB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D011241:Prednisone
Khimioluchevoe lechenie bol'nykh s agressivnymi nekhodzhkinskimi limfomami v I--II stadiiakh zabolevaniia.