[Effects of histamine H2-receptor antagonists on hemopoietic reconstruction in bone marrow].
The effects of histamine H2-receptor antagonists (cimetidine and ranitidine) on bone marrow hematopoiesis of normal and sublethally irradiated mice were investigated. It was found that non-toxic dosage of cimetidine had no significant effect on CFU-s of the normal mouse, but it inhibited CFU-GM growth with a dosage-dependent relationship and the recovery of CFU-s formation from sublethal gamma-ray irradiation. These results suggest that histamine may play a role in bone marrow regeneration after sublethal irradiation. Histamine H2-receptor antagonists can inhibit hemopoietic reconstruction in regenerating bone marrow.
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D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002927:Cimetidine / Q000494:pharmacology; D003037:Cobalt Radioisotopes; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011899:Ranitidine / Q000494:pharmacology
D003037:Cobalt Radioisotopes; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine