[Antiplatelet aggregation effect of Andregraphis paniculata].
This article deals with the antiplatelet aggregation effect of Andregraphis paniculata (AP), 61 blood samples and 8 volunteers were investigated to observe the effect of AP on platelet function in vitro and in vivo respectively. The results showed that the crude extract of AP could inhibit significantly one-phase and two-phase platelet aggregation induced by ADP (P less than 0.001, 0.01). The potency of AP crude extract seemed to be somewhat stronger than Ligustrazine and Persantin injection in vitro, but the difference was not statistically significant (P greater than 0.05). A dose-effect relationship of AP was demonstrated also (r = 0.93). The rapid effect of this drug on platelet aggregation in vivo suggested that AP could be absorbed quickly, but the effect lasted for only a short time. 12 hours after with-drawing of AP, the 1 minute and 5 minutes aggregation rates increased by 18.67%, 36.63% respectively, as compared with the lowest aggregation rate after administration. The activating effect of AP on fibrinolysis was also detected by shortened euglobulinlysis time (211.50 vs 182.50 min in vitro, 219.38 vs 149.38 min in vivo, P less than 0.001). In addition, the influence of AP upon coagulation and thrombelastogram was determined. This study suggested that AP in a promising antithrombogenic agent. This drug might be beneficial in preventing and treating arterial thrombotic diseases.
Tan
H
H
Tang
J Z
JZ
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013916:Thrombelastography
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors