title: [Therapy of resistant duodenal ulcer].
abstract: Significant progress has been made in the treatment of duodenal ulcers since cimetidine went on the market. Furthermore widespread use of the H2 blockers has enable us to identify a group of patients who take 8-12 weeks to heal, despite effective treatment and who are now known as "slow" or non-responders. In tackling the problem of ulcers resistant to medical treatment, the paper details the possibilities offered by current solutions on the basis of personal experience as well as reports in the literature. The results obtainable by surgery are also assessed with emphasis on the identification of suitable patients for and the appropriate timing of his surgical option. Finally a therapeutic flow-chart providing guidelines for the rational selection of therapeutic strategies that still had to be based on uncodified personal preferences is proposed.
authors.affiliation: Università degli Studi di Palermo, Istituto di Medicina Interna e Geriatria.
authors.forename: S
authors.initials: S
authors.lastname: Vigneri
authors.forename: A
authors.initials: A
authors.lastname: Scialabba
authors.forename: G
authors.initials: G
authors.lastname: Pisciotta
authors.forename: R
authors.initials: R
authors.lastname: Termini
authors.forename: F
authors.initials: F
authors.lastname: Muratore
authors.forename: M
authors.initials: M
authors.lastname: Vinti
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005500:Follow-Up Studies; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors; D014629:Vagotomy, Proximal Gastric; D015167:Vagotomy, Truncal
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D010276:Parasympatholytics
vernacular_title: Terapia dell'ulcera duodenale resistente.