The effect of some anti-ulcer agents on the early vascular injury of gastric mucosa induced by ethanol in rats.
The effect of some gastroprotective agents cysteamine, sodium salicylate, atropine, cimetidine, and pyrido-pyrimidine derivatives, rimazolium, Ch-127 and a mast cell stabilizer, BMY-26517-31 was studied on the enhanced vascular permeability of gastric mucosa induced by 100% ethanol, on the enhanced vascular permeability of peritoneal blood vessels due to 0.3% acetic acid and on carrageenin edema test. We found that cysteamine, sodium salicylate, rimazolium and BMY-26517-31 inhibited the alcohol-induced enhanced vascular permeability. They also decreased the carrageenin-induced edema and--with the exception of BMY-26517-31--the acetic-acid-induced enhanced vascular permeability of the peritoneal vessels. These results suggest that similar events are present in the early phase of acute inflammation and chemically induced mucosal lesions. Consequently, antiinflammatory activity might play role in the protective mechanism of some anti-ulcer agents.
Gyires
K
K
Department of Pharmacology, Semmelweis University, Medical School, Budapest, Hungary.
Hermecz
I
I
Knoll
J
J
D000085:Acetates / Q000037:antagonists & inhibitors; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D000431:Ethanol / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects*; D051379:Mice; D051381:Rats; D013997:Time Factors
D000085:Acetates; D000897:Anti-Ulcer Agents; D000431:Ethanol; D002351:Carrageenan; D019342:Acetic Acid