Gender differences between the effect of monosodium glutamate on food intake in rats.
Monosodium glutamate (MSG) was recently reported to increase feeding in ad lib. fed rats [Reddy et al.(4)]. In the present study the responses of male and female adult rats to subcutaneous (SC) administration of MSG were compared. In female rats MSG 3 g/kg did not significantly affect food or water intake as compared with SC NaCl 0.9%; MSG 6 g/kg significantly reduced food intake but increased water intake. On the contrary, in male rats MSG 6 g/kg significantly increased food and water intake. It is concluded that there are differences between genders of rats in what concerns the effect of glutamate on food intake.
Racotta
R
R
Departmento de Fisiologia, Escuela Nacional de Ciencias Biológicas, IPN, México, D.F.
Hernandez-Garcia
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D012970:Sodium Glutamate