Susceptibility of clinical isolates to cephalexin, cefazolin and cefotaxime.
Three hundred and seventeen recent clinical isolates were tested for in vitro susceptibility to the three cephalosporins available in India--cephalexin, cefazolin and cefotaxime by the Kirby--Bauer disc diffusion method. Cefazolin was the most effective cephalosporin against Gram positive cocci (71.8% sensitive) followed by cefotaxime (62.7%) and cephalexin (52.7%). Cefotaxime was very effective against commonly isolated Gram negative bacilli with only 10 (8.8%) isolates being resistant to it while 44 (39%) and 65 (57.5%) were resistant to cefazolin and cephalexin, respectively. All isolates of Pseudomonas aeruginosa were resistant to cephalexin and cefazolin and only 29 (32.6%) were sensitive to cefotaxime.
Gupta
B L
BL
Tahlan
A
A
Dogra
V
V
Rattan
A
A
Bhujwala
R A
RA
Shriniwas
D002437:Cefazolin / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology*; D002506:Cephalexin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005069:Evaluation Studies as Topic; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans
D002437:Cefazolin; D002439:Cefotaxime; D002506:Cephalexin