title: Susceptibility of clinical isolates to cephalexin, cefazolin and cefotaxime.
abstract: Three hundred and seventeen recent clinical isolates were tested for in vitro susceptibility to the three cephalosporins available in India--cephalexin, cefazolin and cefotaxime by the Kirby--Bauer disc diffusion method. Cefazolin was the most effective cephalosporin against Gram positive cocci (71.8% sensitive) followed by cefotaxime (62.7%) and cephalexin (52.7%). Cefotaxime was very effective against commonly isolated Gram negative bacilli with only 10 (8.8%) isolates being resistant to it while 44 (39%) and 65 (57.5%) were resistant to cefazolin and cephalexin, respectively. All isolates of Pseudomonas aeruginosa were resistant to cephalexin and cefazolin and only 29 (32.6%) were sensitive to cefotaxime.
authors.forename: B L
authors.initials: BL
authors.lastname: Gupta
authors.forename: A
authors.initials: A
authors.lastname: Tahlan
authors.forename: V
authors.initials: V
authors.lastname: Dogra
authors.forename: A
authors.initials: A
authors.lastname: Rattan
authors.forename: R A
authors.initials: RA
authors.lastname: Bhujwala
authors.lastname: Shriniwas
mesh_terms: D002437:Cefazolin / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology*; D002506:Cephalexin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005069:Evaluation Studies as Topic; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans
chemical_list: D002437:Cefazolin; D002439:Cefotaxime; D002506:Cephalexin