title: [Microbial mutagenicity testing of N-nitrosoiminostilbene and N-nitrosoiminodibenzyl, the nitrosation products of the drugs carbamazepine and trimipramine hydrochloride].
abstract: The active agents of the drugs Finlepsin and Herphonal, carbamazepine and trimipramine, were nitrosated under simulated human gastric conditions. For both formed N-nitroso compounds, N-nitroso iminostilbene (N-nitroso-5H-dibenz(b,f)azepine) and N-nitroso iminodibenzyl (N-nitroso-10,11-dihydro-5H-dibenz(b,f)azepine), tests for mutagenic potency in the Ames-test gave negative results.
authors.affiliation: Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
authors.forename: D
authors.initials: D
authors.lastname: Ziebarth
authors.forename: T
authors.initials: T
authors.lastname: Schramm
authors.forename: R
authors.initials: R
authors.lastname: Braun
mesh_terms: D002220:Carbamazepine / Q000378:metabolism*; D003984:Dibenzazepines / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D015538:Nitrosation; D014299:Trimipramine / Q000378:metabolism*
chemical_list: D003984:Dibenzazepines; D009153:Mutagens; D009602:Nitrosamines; D002220:Carbamazepine; C061273:N-nitrosodibenzazepine; D014299:Trimipramine; C061274:N-nitrosodihydrodibenzazepine
vernacular_title: Mikrobielle Mutagenitätstestungen von N-Nitroso-iminostilben und N-Nitroso-iminodibenzyl, den Nitrosierungsprodukten der Arzneimittelwirkstoffe Carbamazepin und Trimipraminhydrochlorid.