Changes in pulmonary function during and after bleomycin treatment in patients with testicular carcinoma.
Pulmonary function tests, including spirometry, transfer factor of the lungs for carbon monoxide (TlCO), and the two components of TlCO, the diffusing capacity of the alveolocapillary membrane (Dm) and pulmonary capillary blood volume (Vc), were carried out in a group of patients with testicular carcinoma during and after treatment with the Einhorn regimen. The lung function parameters of patients who developed bleomycin-induced pneumonitis were compared with those recorded in a group of patients who did not develop this syndrome. We suggest that bleomycin-induced damage to the pulmonary capillary vasculature can be monitored by measuring Vc and that ensuing fibrosis can be measured by recording Dm. The decrease in Dm is probably compensated for by an increase in Vc, leading to a smaller change in TlCO.
van Barneveld
P W
PW
Veenstra
G
G
Sleijfer
D T
DT
van der Mark
T W
TW
Mulder
N H
NH
Schraffordt Koops
H
H
Sluiter
H J
HJ
Peset
R
R
D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D002196:Capillaries / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D011652:Pulmonary Circulation / Q000187:drug effects; D013736:Testicular Neoplasms / Q000188:drug therapy*; D013997:Time Factors
D001761:Bleomycin