Measurement of the relative binding affinity of zearalenone, alpha-zearalenol and beta-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: an indicator of estrogenic potencies.
1. The relative binding affinity of zearalenone, alpha-zearalenol, and beta-zearalenol for estrogen receptors was determined in the pig, rat and chicken. 2. Similar relative binding patterns were observed, with alpha-zearalenol exhibiting greater affinity than zearalenone and beta-zearalenol the least binding affinity in all species. 3. The relative binding affinity of alpha-zearalenol was greater in pig, than in rat and significantly greater than in chicken. 4. Interspecies differences in zearalenone sensitivity may be due to the binding affinity of alpha-zearalenol for estrogen receptors and differences in zearalenone metabolites formed.
Fitzpatrick
D W
DW
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada.
Picken
C A
CA
Murphy
L C
LC
Buhr
M M
MM
D000818:Animals; D002645:Chickens; D004054:Diethylstilbestrol / Q000378:metabolism; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D010057:Oviducts / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism*; D012118:Resorcinols / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine; D014599:Uterus / Q000378:metabolism*; D015025:Zearalenone / Q000378:metabolism*; D015029:Zeranol / Q000031:analogs & derivatives / Q000378:metabolism*
D011960:Receptors, Estrogen; D012118:Resorcinols; C029659:zearalenol; D015025:Zearalenone; D004054:Diethylstilbestrol; D015029:Zeranol