[The role of sulfhydryls in indomethacin-induced gastric mucosal injury in rats].
The possible role of sulfhydryls in indomethacin-induced gastric mucosal injury was studied. No significant decrease of the contents of both non-protein and protein-binding sulfhydryls was observed in the gastric mucosa during injury. Indomethacin-induced gastric ulcer was inhibited by cysteamine of 132 and 264 mumol, i.g. or of 132 mumol, s.c. by 82%, 92% and 75% respectively. Such protective effect was not observed with cysteine in equal molar dose. Subcutaneously injected cysteamine (132 mumol) inhibited gastric acid secretion by 46% in indomethacin-treated rats, while no effect was observed on acid secretion when cysteamine was given intragastrically. Cysteamine, given through both routes, did not affect gastric barrier mucus secretion. It is suggested that sulfhydryls in gastric mucosa are not involved in the mechanism of indomethacin-induced injury and that the potent cytoprotective effect of cysteamine against indomethacin-induced ulcer maybe not caused by its sulfhydryl group.
Liu
J L
JL
Zhang
X J
XJ
Wang
C C
CC
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology*; D007213:Indomethacin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D003543:Cysteamine; D007213:Indomethacin