[The role of endogenous enkephalins in the regulation of bone marrow hematopoiesis in stress].
A study was made of the effect of the enkephalinase inhibitor D-phenylalanine on hematopoiesis during the immobilization stress. The long-term treatment with D-phenylalanine before the immobilization stress resulted in a significant increase of plasma ley-enkephalin in mice during the first day after exposure. Later the inhibition of bone marrow hyperplasia was recorded. There were no changes in hematopoiesis provided D-phenylalanine was injected after the immobilization. It is suggested that endogenous enkephalins may take part in the regulation of hematopoiesis at the early period of the stress reaction formation.
Go'ldberg
E D
ED
Zakharova
O Iu
OIu
Dygaĭ
A M
AM
Kozlovskaia
M M
MM
Lishmanov
Iu B
IuB
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D004743:Enkephalin, Leucine / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008297:Male; D051379:Mice; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000473:pathology / Q000503:physiopathology*
D004743:Enkephalin, Leucine
Ob uchastii éndogennykh énkefalinov v reguliatsii kostno- mozgovogo krovetvoreniia pri stresse.