[The role of oxygen free radical and free radical scavenger in septic and hemorrhagic shock].
The roles of oxygen free radical (O2-), lipoperoxide (LPO) and free radical scavenger were clinically and experimentally studied in septic and hemorrhagic shock. The reduction of hepatic tissue blood flow (TBF) were equalized in two groups (40-55% of normal level) and rats were subdivided into 3 groups: untreated, normal saline (NS) continuous IV and superoxide dismutase: SOD + catalase (S/c) continuous IV as free radical scavenger. The change of TBF, destruction of mitochondrial structure and elevation of LPO were prevented by S/c in Et shock. No significant effect by S/c was observed in hemorrhagic shock. The neutrophil derived O2- was markedly elevated in Et shock animals as well as septic shock patients but no significant change was noted in hemorrhagic shock animals or non septic shock patient. SOD and catalase were effective for neutrophil derived O2- in septic shock whereas little beneficial effect was noted in hemorrhagic or non septic shock.
Kadota
T
T
First Department of Surgery, National Defense Medical College, Tokorozawa, Japan.
Ono
H
H
Aihara
T
T
Mochizuki
H
H
Tamakuma
S
S
D000818:Animals; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation; D008102:Liver Circulation; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D012771:Shock, Hemorrhagic / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000494:pharmacology
D005609:Free Radicals; D013482:Superoxide Dismutase; D010100:Oxygen