Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent.
KW-5805 (a new antiulcer agent), given p. o. at 30 mg/kg to rats, significantly increased the amount of gastric adherent mucus and mucosal glycoproteins. Gastric mucosal glucosamine synthetase activity was significantly enhanced by KW-5805 (30 mg/kg, p. o.). KW-5805 (10, 30 mg/kg, p. o.) significantly suppressed the decrease of gastric mucosal blood volume and oxygen sufficiency induced by hemorrhagic shock. The agent also significantly inhibited the extravasation of Evans blue into the gastric mucosa after ischemia-reinfusion. In conclusion, KW-5805 increased biosynthesis, storage and secretion of gastric mucus and improved the gastric mucosal hemodynamics.
Tanaka
H
H
Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Kosaka
N
N
Tomaru
A
A
Shuto
K
K
Ogihara
T
T
Sato
N
N
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001584:Benzoxepins / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism / Q000502:physiology*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D008297:Male; D009093:Mucus / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D000897:Anti-Ulcer Agents; D001584:Benzoxepins; D006023:Glycoproteins; C047874:gastric mucus glycoproteins; C055432:KW 5805; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)