Physiological antagonism between prostaglandin E2 and neuropeptide Y on thermoregulation in the dog.
These experiments were undertaken to determine whether neuropeptide Y (NPY) could suppress a prostaglandin hyperthermia in conscious dogs. Prostaglandin E2 (PGE2) (5 micrograms), injected into the lateral cerebral ventricle (ILV), evoked a hyperthermia of approximately 1 degrees C. Addition of ILV NPY (5 micrograms) significantly attenuated the PGE2-induced hyperthermia, whereas pancreatic polypeptide (PP), another member of the PP family peptide, did not. These results provide evidence for a role of NPY on thermoregulation in the dog.
Inui
A
A
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Morioka
H
H
Okita
M
M
Inoue
T
T
Sakatani
N
N
Oya
M
M
Hatanaka
H
H
Mizuno
N
N
Oimomi
M
M
Baba
S
S
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004285:Dogs; D007276:Injections, Intraventricular; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D009478:Neuropeptide Y; D015232:Dinoprostone