title: First-use reactions: a potential hazard for referral centers.
abstract: First-use reactions comprise a spectrum of adverse clinical signs and symptoms occurring in end-stage renal failure patients during hemodialysis treatments. This report describes four patients experiencing first-use reactions in the context of being referred to or from a tertiary care inpatient dialysis facility. Theories on the pathogenesis of first-use reactions are reviewed and recommendations for identifying patients at increased risk for this problem are proposed.
authors.affiliation: Nephrology Section, Medical College of Georgia, Augusta.
authors.forename: R J
authors.initials: RJ
authors.lastname: Caruana
mesh_terms: D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities / Q000592:standards*; D005260:Female; D006436:Hemodialysis Units, Hospital / Q000592:standards*; D006757:Hospital Units / Q000592:standards*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D011786:Quality Control; D012017:Referral and Consultation; D006435:Renal Dialysis / Q000009:adverse effects*