[Immunosuppressive therapy with low cyclosporin A doses in rats].
An optimum blood level of cyclosporine-A (Cs-A) after allotransplantation in rats is very important for the survival of the transplanted organ. An auxiliary allotransplantation of the heart into the abdominal cavity were carried out in 10 rats. A Cs-A blood level of 200 to 300 ng ml was obtained by administration in the animal food in a dosage of 7 mg kg body weight day. A rejection of the graft was prevented in this way without any symptom of toxicity during 90 days. The results of the experiments were well reproducible. The obtained Cs-A blood level is relatively stationary, frequent laboratory tests are not necessary.
Klika
T
T
Institut für Klinische und Experimentelle Medizin Prag.
Poledne
R
R
Havlícková
J
J
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D006937:Hypercholesterolemia; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins
Immunsuppressive Therapie mit niedrigen Cyclosporin-A-Dosen bei Ratten.