[The effect of anaprilin (obzidan) on adrenergic-dependent adaptive reactions of the body under conditions of prolonged stress exposure].
The conditions of some biochemical and functional systems of the rat organisms at daily intramuscular injections of obsidan (0.05 mg/100 g body weight) for one month were studied to evaluate the effect of obsidan on the adrenergic-dependent adaptive reactions. It was shown that the procedure of injections itself (the control group of animals receiving injections of sodium chloride isotonic solution) is stress leading to a decrease of beta-adrenergic-dependent reactions and an increase of alpha-adrenergic-dependent ones. The combination of this stress with the pharmacological effect of obsidan is characterized by a decrease of adrenaline release in blood, a reduction of manifestations of alpha-adrenergic reactions, a decline of lipid energy substrates consumption level.
Alekseeva
L M
LM
Apollonova
L A
LA
Belopol'skiĭ
A A
AA
Kolesova
O E
OE
Lebkova
N P
NP
D000222:Adaptation, Physiological / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D000818:Animals; D006321:Heart / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D013152:Splanchnic Circulation / Q000187:drug effects; D013312:Stress, Physiological / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors
D011941:Receptors, Adrenergic; D011433:Propranolol
Vliianie anaprilina (obzidana) na adrenozavisimye adaptivnye reaktsii organizma v usloviiakh dlitel'nogo stressornogo vozdeĭstviia.