title: The hepatoprotective principle of Hypoestes triflora leaves.
abstract: Hypoestes triflora is frequently used in Rwandese native medicine to treat hepatic diseases. Premedication with a water extract of the leaves prevented the prolongation of the barbiturate sleeping time associated with carbon tetrachloride-induced liver damage in mice. The compound responsible for this protective activity was benzoic acid. Mice previously treated with benzoic acid also showed a significant diminution of the increased GOT and GPT levels seen after carbon tetrachloride administration.
authors.affiliation: Centre Universitaire de Recherche sur la Pharmacopée et la Médecine Traditionnelle, Faculté des Sciences, Université Nationale du Rwanda, France.
authors.forename: L
authors.initials: L
authors.lastname: Van Puyvelde
authors.forename: A
authors.initials: A
authors.lastname: Kayonga
authors.forename: P
authors.initials: P
authors.lastname: Brioen
authors.forename: J
authors.initials: J
authors.lastname: Costa
authors.forename: A
authors.initials: A
authors.lastname: Ndimubakunzi
authors.forename: N
authors.initials: N
authors.lastname: De Kimpe
authors.forename: N
authors.initials: N
authors.lastname: Schamp
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001565:Benzoates / Q000302:isolation & purification; D019817:Benzoic Acid; D002252:Carbon Tetrachloride Poisoning; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010946:Plants, Medicinal; D012432:Rwanda; D012890:Sleep / Q000187:drug effects
chemical_list: D001565:Benzoates; D019817:Benzoic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010424:Pentobarbital