Stimulation of peripheral blood lymphocytes of HIV-infected patients by jacalin, a lectin mitogenic for human CD4+ lymphocytes.
The proliferative response of peripheral blood mononuclear cells stimulated by jacalin was investigated in 157 samples from 104 HIV-infected patients at various clinical stages of disease. Jacalin proliferative response correlated with the absolute numbers and percentages of CD4+ lymphocytes and with the percentages of Leu 8 lymphocytes. It correlated negatively with the percentages of CD8+ and CD38+ lymphocytes. It was depressed during acute HIV infection and at advanced stages. The response in Centers for Disease Control groups II and III was heterogeneous and similar; in both, some patients showed a very low response. Further follow-up of the present patients should indicate whether jacalin responsiveness has a prognostic value.
Pineau
N
N
Laboratory of Immunology and Immunopathology (CNRS URA, 1172), France.
Brugier
J C
JC
Breux
J P
JP
Becq-Giraudon
B
B
Descamps
J M
JM
Aucouturier
P
P
Preud'homme
J L
JL
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005500:Follow-Up Studies; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D037121:Plant Lectins; D013268:Stimulation, Chemical
D037102:Lectins; D037121:Plant Lectins; C043696:jacalin