Neuroleptic and anti-depressant drug treatment abolishes conditioned immunosuppression in mice.
Mice previously exposed to cyclophosphamide in the presence of saccharin-flavored water will show a decreased antibody response to challenge with sheep erythrocytes if simultaneously they are again given saccharin to drink. These mice also show conditioned taste aversion. Treatment of conditioned animals with chlorpromazine or amitriptyline after challenge with erythrocytes in the presence of saccharin reduced the degree of immunosuppression and, though to a lesser degree, the conditioned taste aversion.
Gorczynski
R M
RM
Department of Surgery, University of Toronto, Ontario, Canada.
Holmes
W
W
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013649:Taste
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000639:Amitriptyline; D003520:Cyclophosphamide; D002746:Chlorpromazine