title: Gastrin and somatostatin cells in dyspeptic patients with and without duodenal ulcer: a quantitative study based on multiple biopsy specimens.
abstract: The numbers of immunoreactive gastrin and somatostatin cells in gastric and duodenal mucosal biopsy specimens from dyspeptic patients with duodenal ulcers and dyspeptic controls without ulcers were calculated using a morphometric method. The levels of gastrin and somatostatin in the tissue were also measured by the radioimmunoassay. The results showed no significant difference in the number of G cells and the level of gastrin in the tissue between the ulcer and non-ulcer groups. However, the number of D cells and the level of somatostatin in the tissue in ulcer patients were remarkably reduced in comparison with those in non-ulcer patients (P less than 0.01 and P less than 0.05, respectively). The G:D cells and gastrin:somatostatin ratios in ulcer patients were much higher than those in the non-ulcer control group. It is considered that the reduction of D cells and the relative lack of somatostatin in duodenal ulcer patients might have a role in the mechanism of the duodenal ulceration.
authors.affiliation: Peking Union Medical College Hospital, Beijing, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: T H
authors.initials: TH
authors.lastname: Liu
authors.forename: S F
authors.initials: SF
authors.lastname: Ye
authors.forename: C F
authors.initials: CF
authors.lastname: Gu
authors.forename: S P
authors.initials: SP
authors.lastname: Chen
mesh_terms: D001706:Biopsy; D004381:Duodenal Ulcer / Q000473:pathology*; D004415:Dyspepsia / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology*; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis*
chemical_list: D005755:Gastrins; D013004:Somatostatin