Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (3 mg/kg). These results suggest that manidipine may be useful for treating hypertension.
Nagaoka
A
A
Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Shibota
M
M
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009529:Nicardipine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D009578:Nitrobenzenes; D010879:Piperazines; D051381:Rats; D011918:Rats, Inbred SHR; D012079:Renal Circulation / Q000187:drug effects; D014563:Urodynamics / Q000187:drug effects
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D004573:Electrolytes; D009578:Nitrobenzenes; D010879:Piperazines; C054218:manidipine; D009529:Nicardipine; D009543:Nifedipine