The effect of human chorionic gonadotropin on serum levels of testosterone, estradiol, and sexual behavior in young and old rhesus males.
Sexual behavior and serum levels of testosterone (T) and estradiol (E) were examined in five young and six old rhesus males (Macaca mulatta) before and after the injection of 500 and 1000 IU of HCG. The serum levels of T and E increased in both young and old males after injection of either dose of HCG. Serum levels of T were significantly higher in young than in old males in the period following the last injection of 1000 IU of HCG. Old males had significantly higher levels of serum E during treatment with 1000 IU of HCG, but serum E levels in the two groups did not differ before or after treatment. Serum levels of T and E did not differ between the young and old males when injected with 500 IU of HCG. HCG had no effect on sexual performance and the differences in levels of sexual performance between the young and old males were not eliminated.
Phoenix
C H
CH
Oregon Regional Primate Research Center, Beaverton, 97006.
Walther
A M
AM
Jensen
J N
JN
Chambers
K C
KC
D000367:Age Factors; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D004958:Estradiol / Q000097:blood*; D008253:Macaca mulatta; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D013739:Testosterone; D004958:Estradiol