Measurement of renal functions by double isotope techniques in elderly patients during tenoxicam therapy.
Four elderly patients (aged 68-87 yr) with osteoarthritis were treated with 20 mg of tenoxicam (a new non-steroidal anti-inflammatory drug) daily for at least 12 weeks. Tenoxicam did not appear to have any harmful effect on glomerular filtration rate and effective renal plasma flow, as measured by a single intravenous injection of 51Cr-EDTA and 125I-iodohippurate. Plasma concentration of tenoxicam indicated good compliance, and no evidence of unexpected accumulation of tenoxicam in the plasma was observed during 12 weeks of medication.
Ghose
K
K
Department of Geriatric Medicine, Cardiff Royal Infirmary, UK.
Burch
A
A
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002860:Chromium Radioisotopes; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007457:Iodine Radioisotopes; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010894:Piroxicam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes; D010894:Piroxicam; C032801:tenoxicam