title: Kinetics of sodium activation in giant axons of squid (Doryteuthis bleekeri).
abstract: The variation with time of the rising phase of the sodium conductance in squid giant axons was fitted to the Xth power of running integrals of the colchicine-sensitive components of the asymmetry currents, where the running integrals were experimentally obtained. We found that excellent fitting was obtained for all of the potentials examined from -60 to +60 mV, when we put the value of X equal to 3 at potentials above 10 mV and equal to 5 below -20 mV, and it varied continuously from 3 to 5 when pulse potentials changed from 10 to -25 mV. Further, it was found that the voltage dependence of the peak sodium currents was fitted to the third power of charges carried by the colchicine-sensitive component of the asymmetry current by the moment when the sodium current attained its peak. These results agree well with the expectation by Hodgkin and Huxley [(1952) J. Physiol., Lond. 117, 500-544] although the gating kinetics differ from the Hodgkin-Huxley prediction [Matsumoto, Ichikawa and Tasaki (1983) J. Membr. Biol. 77, 93-99].
authors.forename: G
authors.initials: G
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology; D049832:Decapodiformes; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D012964:Sodium / Q000502:physiology*
chemical_list: D007473:Ion Channels; D012964:Sodium; D003078:Colchicine