[Antibodies to type I and II collagen in rheumatoid arthritis and chronic cicatricial stenosis of the larynx and trachea in children].
Enzyme immunoassay with highly purified human collagen preparations and low (1:10) dilutions of sera detected an increased specific immune reaction mostly on collagen denaturated forms in 50% of 49 patients with rheumatoid arthritis. No correlation was detected between the level of humoral immune response and the major clinical parameters except those reflecting the disease progress. Similar investigation of sera from children with chronic cicatricial stenoses has revealed a group of patients with significantly elevated level of anticollagen humoral immune response, though in these patients this response is probably not specifically associated with collagen.
Shuster
A M
AM
Chichasova
N V
NV
Galkina
L V
LV
Domogatskiĭ
S P
SP
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D002921:Cicatrix / Q000150:complications; D003094:Collagen / Q000276:immunology*; D006801:Humans; D007829:Laryngostenosis / Q000209:etiology / Q000276:immunology*; D014135:Tracheal Stenosis / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D003094:Collagen
Antitela k kollagenam I i II tipov pri revmatoidnom artrite i khronicheskom rubtsovom stenoze gortani i trakhei u deteĭ.