title: Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects.
abstract: Salbutamol was administered intravenously to 5 patients with renal function impairment for estimation its pharmacokinetic parameters. The mean terminal half-life was 256 min, similar to previously reported values in healthy adults. The mean clearance (167 ml/min) and the mean volume of distribution (551) were decreased. These parameters were not correlated with the creatinine clearance. A slight but significant decrease was observed in the plasma potassium level up to 125 min after the salbutamol infusion. The heart rate was significantly increased, and the increase in 3 patients was correlated with the salbutamol concentration. The biological effects of the drug were less marked than expected.
authors.affiliation: Département de pharmacologie clinique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Rey
authors.forename: L
authors.initials: L
authors.lastname: Luquel
authors.forename: M O
authors.initials: MO
authors.lastname: Richard
authors.forename: B
authors.initials: B
authors.lastname: Mory
authors.forename: G
authors.initials: G
authors.lastname: Offenstadt
authors.forename: G
authors.initials: G
authors.lastname: Olive
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000378:metabolism*; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy / Q000209:etiology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000652:urine
chemical_list: D000420:Albuterol; D011188:Potassium