Chlordecone interaction with catecholamine binding and uptake in rat brain synaptosomes.
The in vitro and in vivo effects of chlordecone on rat brain synaptosomal binding and uptake of 3H-dopamine and 3H-norepinephrine were determined. The data show that chlordecone decreases both binding and uptake of the 3H-catecholamines in vitro and in vivo. The uptake of 3H-dopamine was more sensitive to chlordecone than binding. 3H-norepinephrine binding and uptake was decreased to a lesser degree as compared to dopamine. In general, chlordecone at about 25-50 microM concentration produced a 50% decrease of the ligands binding and uptake. Mirex, a non-neurotoxic compound and a structural analog of chlordecone altered neither binding nor uptake of the ligands tested. These studies suggest that chlordecone may be modulating the pre and post synaptic function.
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D000818:Animals; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D007631:Chlordecone / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008917:Mirex / Q000633:toxicity; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*
D002395:Catecholamines; D007306:Insecticides; D007631:Chlordecone; D004298:Dopamine; D009638:Norepinephrine; D008917:Mirex