[Somatostatin in the emergency treatment of upper digestive hemorrhage in patients with portal hypertension].
During a 2-yr period 15 patients (17 episodes) with variceal bleeding (VB) and 7 with cirrhosis and acute gastroduodenal haemorrhage (GDH) received intravenous somatostatin (250 mcg per hr after a bolus of 250 mcg). Initial control of bleeding was achieved in 13 (76%) with VB and in all with GDH. Three of the 4 patients with VB and 2 with GDH who rebled during treatment were controlled increasing the infusion to 500 mcg/hr. Patients with VB received somatostatin for 24 hrs, time selected for initiating injection sclerotherapy, and those with GDH for 48-72 hrs. At 24 hrs 71% of patients with VB and all with GDH were free of bleeding. Combining different therapies VB was controlled in 16 of the 17 episodes (94%) with only one death. No complications were observed in any of the 22 patients treated.
Villamil
F G
FG
Hospital Italiano de Buenos Aires, Terapia Intensiva y Gastroenterología.
Perman
M
M
Gallesio
A
A
Butera
M
M
Soifer
L
L
Aziz
H
H
San Román
E
E
D000328:Adult; D000368:Aged; D004630:Emergencies; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D013004:Somatostatin / Q000627:therapeutic use*
D012597:Sclerosing Solutions; D013004:Somatostatin
Somatostatina en el tratamiento de emergencia de la hemorragia digestiva alta en hipertensos portales.