title: Hepatic-portal and cardiac infusion of CCK-8 and glucagon induce different effects on feeding.
abstract: In order to compare effects of circulating CCK-8 and glucagon on food intake, rats were provided with a permanently implanted catheter in the right atrium. Another cannula was implanted into the hepatic-portal vein by a new technique. After a standard fasting period graded loads of CCK-8 and glucagon were infused via these catheters during refeeding. Intracardiac glucagon and CCK loads dose-dependently suppressed meal size. Intraportal infusion of glucagon caused similar suppression compared to intracardiac administration. This may indicate a minor role of the liver as a target for the suppression of feeding by glucagon. In contrast, intraportal infusion of CCK-8 did not reduce food intake. The results indicate that CCK-8 is removed or inactivated by the liver. It is suggested that CCK-8 acts locally on vagal nerve endings to exert its suppressive action on food intake.
authors.affiliation: Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Strubbe
authors.forename: J G
authors.initials: JG
authors.lastname: Wolsink
authors.forename: A M
authors.initials: AM
authors.lastname: Schutte
authors.forename: B
authors.initials: B
authors.lastname: Balkan
authors.forename: A J
authors.initials: AJ
authors.lastname: Prins
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005934:Glucagon / Q000008:administration & dosage*; D006325:Heart Atria; D008297:Male; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*; D012528:Satiety Response / Q000187:drug effects*; D012844:Sincalide / Q000008:administration & dosage*
chemical_list: D005934:Glucagon; D012844:Sincalide