[Bronchial manifestation of drug-induced complications].
Bronchial side effects of drugs are varied and numerous. The most frequent are the hypersensitivity type 1 and 3 reactions of asthma. Asthma is primarily caused by anti-infectious agents but also by protein drugs (and many others). At the present time, attention is being focused on excipients and solvents: cremophore, anti-oxidative sulfites (E 220 to E 227), found in over 700 drugs and responsible for severe side effects. Other bronchospasms are due to direct or indirect potentiation of parasympathetic bronchomotor tonus, chiefly with alpha-agonists, and perhaps with beta-agonists but this remains to be proven. Asthmatic reactions caused by interference in mediator synthesis are another current topic of study; some are well known, such as histamine release and interference in arachidonic acid metabolism (non-steroidal antiinflammatory drugs). Other side effects are the result of local irritation, obstruction or bronchial stenosis. A drug-induced cough could be a consequence of local irritation or of the action of converting enzyme inhibitors on bradykinin catabolism.
Hugues
F C
FC
Service de Médecine Interne II, Hôpital Laennec, Paris.
Le Jeunne
C
C
Haas
C
C
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced*; D001982:Bronchial Diseases / Q000139:chemically induced*; D001986:Bronchial Spasm / Q000139:chemically induced; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans
D000317:Adrenergic alpha-Antagonists
Expression bronchique des accidents médicamenteux.