[Effect of low molecular dextran on maternal microrheologic parameters, fetal heart rate and transcutaneous fetal oxygen partial pressure in labor].
The results from animal experimental research have shown that the infusion of dextran 40 increased the uterine blood flow mainly by decreasing the vascular resistance and by this improving the oxygen supply to the fetus. Dextran 40 given in a dosage of 50 ml/min within 10 minutes to 11 pregnant women during parturition showed that the fetal blood PO2 increased if the PO2 before infusion was low and decreased if the PO2 before infusion was high. Therefore the question enhanced if the reduced maternal oxygen capacity results in a reduction of fetal PO2 (tcPo2) too. After informed consent 10 healthy pregnant women at term with a normal pregnancy got an infusion of 500 ml dextran 40 during 30 minutes. The following maternal parameters were measured: heart rate, mean arterial blood pressure, intrauterine pressure and transcutaneous carbon dioxide tension (tcPCO2). Maternal microrheological parameters before and after infusion of dextran 40 were estimated as following: plasma viscosity, erythrocyte aggregation, serum osmolality, colloid osmotic pressure, hemoglobin and haematocrit. The mothers were laying in the side position and their ventilation was controlled by tcPco2 (Dräger, Lübeck). The following fetal parameters were registered: basal fetal heart rate, transcutaneous fetal oxygen partial pressure (tcPo2) and the umbilical cord blood gases. After rupture of the fetal membranes and at a cervix dilatation of about 5-7 cm a tcPo2 electrode (Dräger, Lübeck) was fixed at the fetal scalp with an acrylate glue (Histoacryl) and by this fetal tcPo2 and its "flow" registered.(ABSTRACT TRUNCATED AT 250 WORDS)
Kurz
C S
CS
Heilmann
L
L
Ludwig
H
H
D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D005318:Fetal Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006452:Hemoglobinometry; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008970:Molecular Weight; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D012212:Rheology
D003911:Dextrans; D010100:Oxygen
Die Wirkung von niedermolekularem Dextran auf maternale mikrorheologische Parameter, die fetale Herzfrequenz und den transkutanen fetalen Sauerstoff-partialdruck während der Geburt.