Multifocal adenomatous oncocytic hyperplasia in parotid glands with metastatic deposits or primary malignant transformation?
Rare tumorous lesions involving both parotid glands were found in a 90-year-old man at autopsy. The clinical course held together with the histopathological features of the parotid alterations, make it likely that they present a multifocal adenomatous oncocytic hyperplasia. Areas of clear cells and occurrence of papillary malignant foci lead to various differential diagnostic considerations. Series of therapeutic irradiation to both parotid regions with a latency period of 15-35 years perhaps induced multifocal malignant transformation in the oncocytic hyperplastic parotid tissue.
Lidang Jensen
M
M
Department of Pathology, Skive Hospital, Denmark.
D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia; D008297:Male; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000175:diagnosis*