Cardiovascular responses of rats to electrical stimulation of the fastigial nucleus and local microinjection of amino acids.
The cardiovascular response to electrical stimulation of the fastigial nucleus (FN) and microinjection of L-glutamate, kainic acid, glycine and GABA into the FN of anesthetized rats were studied. Electrical stimulation of FN produced pressor or depressor responses with a decrease or no change in heart rate depending upon the intensity or site of the stimulation. Microinjection of L-glutamate or kainic acid into the FN elicited pressor or depressor response with bradycardia, while that of glycine or GABA did not affect blood pressure or heart rate. L-glutamate or kainic acid microinjected into the FN did not affect epinephrine-induced pressor response, but attenuated the bradycardic response. These results indicate that L-glutamate in the FN may play a role in modulation of the cardiovascular regulation.
Huang
T F
TF
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Peng
Y I
YI
Shieh
J Y
JY
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced / Q000517:prevention & control; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002529:Cerebellar Nuclei / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D004837:Epinephrine; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006339:Heart Rate / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D051381:Rats
D000596:Amino Acids; D005971:Glutamates; D018698:Glutamic Acid; D007608:Kainic Acid; D004837:Epinephrine