Twenty-five loci form a continuous linkage map of markers for human chromosome 7.
We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease.
Lathrop
G M
GM
Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132.
O'Connell
P
P
Leppert
M
M
Nakamura
Y
Y
Farrall
M
M
Tsui
L C
LC
Lalouel
J M
JM
White
R
R
D000483:Alleles; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003434:Crossing Over, Genetic; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D005819:Genetic Markers