Chronic imipramine does not block cocaine-induced increases in brain stimulation reward.
Self-stimulating rats implanted with ventral tegmental area electrodes were tested with 15 mg/kg cocaine HCl before and after chronic imipramine treatment. Chronic imipramine had no influence on cocaine's ability to lower brain stimulation reward thresholds, suggesting that tricyclic antidepressant treatment does not block cocaine-induced euphoria.
Frank
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RA
Department of Psychology, University of Cincinnati, OH 45221.
Zubrycki
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E
D000818:Animals; D001921:Brain / Q000502:physiology; D003042:Cocaine / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D007099:Imipramine / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects*
D003042:Cocaine; D007099:Imipramine