title: Chromatin proteins share antigenic determinants with neurofilaments.
abstract: Antigenic determinants common to distinct proteins may be unambiguously identified by the use of monoclonal antibodies. Some monoclonal antibodies to mammalian neurofilaments have recently been shown to cross-react with the neurofibrillary tangles found at high density in the brains of senile dements with Alzheimers disease (SDAT). Here, we show that these antibodies also cross-react with chromatin proteins, including the linker histones H1 and H1(0). Elevated levels of histone H1(0) have also been reported in SDAT brains.
authors.forename: J N
authors.initials: JN
authors.lastname: Wood
authors.forename: N B
authors.initials: NB
authors.lastname: Lathangue
authors.forename: D R
authors.initials: DR
authors.lastname: McLachlan
authors.forename: B J
authors.initials: BJ
authors.lastname: Smith
authors.forename: B H
authors.initials: BH
authors.lastname: Anderton
authors.forename: A J
authors.initials: AJ
authors.lastname: Dowding
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000473:pathology; D002843:Chromatin / Q000032:analysis*; D003429:Cross Reactions; D003599:Cytoskeleton / Q000276:immunology*; D000939:Epitopes / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006657:Histones / Q000276:immunology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000911:Antibodies, Monoclonal; D002843:Chromatin; D000939:Epitopes; D006657:Histones