title: Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat cerebrospinal fluid.
abstract: The humoral immune response to human serum albumin (HSA) microinfused into cerebrospinal fluid (CSF) has been measured in serum, cervical lymph nodes, and spleen of Sprague-Dawley rats. Conditions were designed to promote normal brain barrier function. Serum titers of anti-HSA antibodies, primarily IgG, increased over 10 days and then persisted for at least 10 weeks. A significant role for cervical lymphatics in the systemic response to CSF-administered HSA is suggested, based on results showing that (1) cervical lymph obstruction reduces serum titers of anti-HSA antibodies, and (2) total antibody production by combined superficial and deep cervical nodes, sampled 14 days post-immunization, exceeds that by the spleen.
authors.affiliation: Section of Physiology and Biophysics, Brown University, Providence, RI 02912.
authors.forename: C
authors.initials: C
authors.lastname: Harling-Berg
authors.forename: P M
authors.initials: PM
authors.lastname: Knopf
authors.forename: J
authors.initials: J
authors.lastname: Merriam
authors.forename: H F
authors.initials: HF
authors.lastname: Cserr
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000166:cytology; D002555:Cerebrospinal Fluid; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008297:Male; D009333:Neck; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000008:administration & dosage / Q000276:immunology*; D013154:Spleen / Q000166:cytology
chemical_list: D012709:Serum Albumin