[Effect of oxythiamine disulfides on the pancreas and thyroid of rats].
Single administration of oxythiamine (200 mg/kg) or an isomolar amount of oxythiamineamyldisulfide to rats does not change the content of insulin in 72 h, whereas oxythiaminehexyldisulfide slightly increases the blood level of the hormone. Oxythiamine and its disulfides cause changes of the thyroid indicating considerable suppression of its function. It is assumed that hormonal mediation of oxythiamine nonspecific metabolic effects results predominantly from the involvement of the thyroid hormones rather than insulin.
Kravchenia
N A
NA
Gorenshteĭn
B I
BI
Dezhurova
G A
GA
Lukashik
N K
NK
Ostrovskiĭ
Iu M
IuM
D000818:Animals; D007330:Insulin Antibodies / Q000032:analysis; D010119:Oxythiamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D051381:Rats; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D014174:Transketolase / Q000378:metabolism
D007330:Insulin Antibodies; D011773:Pyruvates; D013844:Thiazoles; D010119:Oxythiamine; C061978:oxythiamine amyl disulfide; C061979:oxythiamine hexyl disulfide; D019289:Pyruvic Acid; D014174:Transketolase
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