IgG subclass deficiency in acute myeloid leukemia.
Serum IgG subclass levels were measured using a competitive indirect immunoenzymatic assay with monoclonal antibodies in 22 acute myeloid leukemia patients at presentation and prior to specific therapy. Three patients had moderate IgG1 deficiency and 1 moderate IgG3 deficiency. Two of the three IgG1 deficient patients (and only one other) failed to respond to induction chemotherapy and the third died of bone marrow aplasia during induction.
Preud'homme
J L
JL
Laboratory of Immunology and immunopathology, CNRS URA 1172, CHUR La Milétrie, Poitriers, France.
Lacombe
C
C
Cordonnier
C
C
Guilhot
F
F
Intrator
L
L
Aucouturier
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D004406:Dysgammaglobulinemia / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal