[The RFLPs of St14/Taq I in Chinese and its application to gene analysis and prenatal diagnosis of hemophilia A].
The genomic DNA fragment St14 (DXS52) is located in q28 region of X chromosome that also contains the hemophilia A locus. The RFLPs of St14/Taq I in Chinese were studied. The frequency of allele 7A (3.6 kb) is 31%, which is obviously different from the data reported abroad. By use of the RFLPs, 8 families with hemophilia A were analysed, including 1 case for first trimester prenatal diagnosis at risk of hemophilia A.
Shen
Y
Y
Institute of Basic Medical Science, Chinese Academy of Medical Science, Beiging.
Wu
G Y
GY
Wang
S W
SW
Gao
Q S
QS
Jiang
X H
XH
Liu
J Z
JZ
Liu
Y
Y
Sun
N H
NH
Wang
F Y
FY
Wu
Y Z
YZ
D044466:Asian People; D002681:China; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014960:X Chromosome