Food restriction and short-term effects of aflatoxin B1 feeding on putative preneoplastic biochemical markers.
The susceptibility of experimental rats to Aflatoxin B1, a well known hepatocarcinogen, during chronic food restriction was studied, using a few putative preneoplastic biochemical markers. Gamma-Glutamyl transpeptidase was the most sensitive among the various enzymes studied, at the dose of 10 micrograms/day/100 gm body weight of Aflatoxin B1 fed over a period of three weeks after a twelve chronic food restriction in experimental rats. It was significantly elevated in the underfed untreated group, thus suggesting that preneoplastic changes may be precipitated during chronic undernutrition and carcinogen exposure.
Rajpurohit
R
R
Food and Drug Toxicology Research Centre, National Institute of Nutrition, Tarnaka, Hyderabad, A.P., India.
Krishnaswamy
K
K
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D002149:Energy Intake; D005952:Glucose-6-Phosphatase / Q000032:analysis; D005966:Glucuronidase / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009748:Nutrition Disorders / Q000503:physiopathology*; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000032:analysis
D014408:Biomarkers, Tumor; D002273:Carcinogens; D016604:Aflatoxin B1; D005723:gamma-Glutamyltransferase; D005952:Glucose-6-Phosphatase; D005966:Glucuronidase