The basal ganglia in chlordecone-induced neurotoxicity in the mouse.
This overview summarizes the available data concerning the neurotoxic effects of chlordecone on the basal ganglia in mice. Included are the effects of chlordecone on motor coordination, levels of biogenic amines, uptake of catecholamines and GABA, release of 3H-dopamine from striatal slices, newly synthesized dopamine, levels of dopamine metabolites in striatum, total and protein-bound Ca++ in discrete areas of brain, and distribution of chlordecone in discrete areas of brain. These data suggest that the basal ganglia may be the brain site at which chlordecone acts to produce its neurotoxic effects.
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D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D007631:Chlordecone / Q000378:metabolism / Q000633:toxicity*; D003342:Corpus Striatum / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism
D007306:Insecticides; D018377:Neurotransmitter Agents; D007631:Chlordecone; D002118:Calcium