Aluminum toxicity and albumin.
During a study of priming solutions for extracorporeal membrane oxygenation (ECMO) in the intensive care nursery, it was discovered that those solutions using certain brands of 25% albumin contained aluminum levels within the toxic range. When the brand was changed to a brand known to have a lower aluminum (Al) content, a marked drop in priming solution Al levels was measured. The heat exchanger was examined as a possible source of soluble Al. No evidence of elevated Al levels was found in fluids perfusing this heat exchanger when compared with a stainless steel heat exchanger. The Al content of various blood products was evaluated along with various brands of 5% albumin and 25% albumin.
Kelly
A T
AT
Children's Hospital National Medical Center, Dept of Neonatology, Washington, DC 20010.
Short
B L
BL
Rains
T C
TC
May
J C
JC
Progar
J J
JJ
D000418:Albumins / Q000008:administration & dosage*; D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D004340:Drug Contamination; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007223:Infant
D000418:Albumins; D000535:Aluminum