title: [Application of straight chain fatty acid analog IPPA [omega-(p-iodophenyl)-pentadecanoic acid] for myocardial imaging--using acute myocardial infarction model].
abstract: Application for myocardial imaging and fundamental experiments were studied using straight chain fatty acid analog IPPA [omega-(p-iodophenyl)-pentadecanoic acid]. Biodistribution of IPPA in rabbits (n = 6) shows the accumulation in liver was maintained 81.0% at 30 minutes, while the accumulations of heart, lungs and kidneys were 30.0%, 10.0% and 15.0% respectively. Especially the accumulation of heart decreased rapidly from 48.0% at 3 minutes to 30.0% at 30 minutes, reflecting the effect of beta oxidation. On the other hand, in the acute myocardial infarction mode (n = 6), with occlusion in left anterior descending coronary artery, all 6 cases showed defect images at the corresponding areas after injection of 3 mCi of IPPA. Myocardial imaging with IPPA should be useful not only for myocardial metabolic diseases (cardiomyopathy etc.) but also for ischemic heart disease.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: J
authors.initials: J
authors.lastname: Yamazaki
authors.forename: I
authors.initials: I
authors.lastname: Okuzumi
authors.forename: T
authors.initials: T
authors.lastname: Uchi
authors.forename: T
authors.initials: T
authors.lastname: Muto
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Wakakura
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Hosoi
authors.forename: T
authors.initials: T
authors.lastname: Morishita
mesh_terms: D000818:Animals; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C025391:omega-(4-iodophenyl)pentadecanoic acid