Pathological analyses on the compressed cord by the experimental spinal metastasis.
The purpose of the present experimental spinal metastasis developed in rats by inoculation of Walker's cancer cells through the spinous process is to find the factor which causes the initial damage of the cord in this disorder. In the early stage of paralysis, microangiogram exhibited that the degenerated posterior funiculus originated from the small hemorrhagic area in the posterior column of the involved cord. Scanning electron microscopic findings showed that the hemorrhage was of the intrinsic vein resulting from the disturbance of venous drainage in the compressed portion. In the early stage of compression, however, vascular permeability was observed in the white matter, but histologic degeneration was not. It was concluded that the trigger to induce the initial damage on the cord in spinal metastasis was likely to be the intrinsic venous hemorrhage.
Manabe
S
S
Department of Orthopaedic Surgery Teikyo University School of Medicine.
Higo
Y
Y
Park
P
P
Tanaka
H
H
Ohno
T
T
D000818:Animals; D002279:Carcinoma 256, Walker / Q000150:complications / Q000473:pathology; D006470:Hemorrhage / Q000150:complications / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000098:blood supply / Q000648:ultrastructure*; D013117:Spinal Cord Compression / Q000209:etiology / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000150:complications / Q000473:pathology; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary*; D014680:Veins