title: Lack of in vivo activation of the interferon system in HBsAg-positive chronic active hepatitis.
abstract: The in vivo activation state of the interferon system was biochemically evaluated in patients with HBsAg-positive liver disease by assaying the interferon-induced enzyme, 2'5'-oligoadenylate synthetase, in peripheral blood mononuclear cells. All patients with chronic active hepatitis had normal levels of enzyme activity. Increased values were found in 77% of patients with acute hepatitis, 50% of those with chronic persistent hepatitis and 54% chronic healthy carriers. These results provide evidence for lack of activation of the interferon system in HBsAg-positive chronic active hepatitis and support the hypothesis that an in vivo defective interferon response may aid in development of chronic active hepatitis.
authors.forename: A
authors.initials: A
authors.lastname: Poitrine
authors.forename: S
authors.initials: S
authors.lastname: Chousterman
authors.forename: M
authors.initials: M
authors.lastname: Chousterman
authors.forename: S
authors.initials: S
authors.lastname: Naveau
authors.forename: M N
authors.initials: MN
authors.lastname: Thang
authors.forename: J C
authors.initials: JC
authors.lastname: Chaput
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood; D000328:Adult; D000368:Aged; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000097:blood / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology
chemical_list: D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase