Puberty-affecting synthetic analogs of urinary chemosignals in the house mouse, Mus domesticus.
Endocrinologically- and socially-dependent volatile constituents of female mouse urine, identified in a previous study, were tested for their capability to accelerate puberty and extend the estrous period in young females. Several volatile ketones advanced puberty by approximately three days and extended the period of vaginal cornification in 55-75% of exposed females. High High concentrations of these substances were capable of overriding the known puberty-delaying chemosignals. Volatile cyclic enol ethers were also effective in extending estrus, but not puberty acceleration.
Jemiolo
B
B
Department of Chemistry, Indiana University, Bloomington 47405.
Andreolini
F
F
Xie
T M
TM
Wiesler
D
D
Novotny
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004971:Estrus / Q000187:drug effects*; D005260:Female; D051379:Mice; D010675:Pheromones / Q000138:chemical synthesis / Q000494:pharmacology* / Q000652:urine; D012741:Sexual Maturation / Q000187:drug effects* / Q000502:physiology
D010675:Pheromones