THF-gamma 2, a thymic hormone, increases immunocompetence and survival in 5-fluorouracil-treated mice bearing MOPC-315 plasmacytoma.
The effect of the thymic hormone, THF-gamma 2, on the immunocompetence of 5-fluorouracil (5-FU)-treated BALB/c mice, bearing MOPC-315 tumor, was examined. Treatment of noninoculated or tumor-bearing mice with THF-gamma 2 after 5-FU injection, resulted in an increase in the antibody response to sheep red blood cells and in the allogeneic response in spleen cell cultures and had no effect on the concanavalin-A-induced interleukin-2 secretion beyond that caused by 5-FU alone. Treatment with either 5-FU alone or 5-FU and THF-gamma 2 resulted in restoration to normal values of Lyt1- and L3T4-positive populations in tumor-bearing mice. THF-gamma 2 prolonged the survival time of mice bearing MOPC-315 tumor beyond that observed in mice treated with 5-FU alone.
Ophir
R
R
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel.
Pecht
M
M
Halperin
D
D
Rashid
G
G
Burstein
Y
Y
Ben-Efraim
S
S
Trainin
N
N
D000818:Animals; D000917:Antibody Formation; D003208:Concanavalin A / Q000494:pharmacology; D005472:Fluorouracil / Q000627:therapeutic use*; D007121:Immunocompetence / Q000187:drug effects*; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010954:Plasmacytoma / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D013951:Thymus Hormones / Q000494:pharmacology*
D007376:Interleukin-2; D013951:Thymus Hormones; D003208:Concanavalin A; C014859:thymic humoral factor; D005472:Fluorouracil