title: Plethysmographic effects of doxazosin in essential hypertensive patients.
abstract: In the treatment of hypertensive patients with peripheral vascular disease, alpha 1-adrenoceptor blockers may be considered first-choice drugs since they reduce the total peripheral resistance and do not decrease the plasma volume. As a preliminary step, we investigated the plethysmographic effects of doxazosin (1-8 mg for 6 weeks) on calf flow in 32 uncomplicated hypertensive patients. Despite the fall in sitting and standing blood pressure (from 163 +/- 18/101 +/- 6 to 147 +/- 19/94 +/- 8 mmHg and from 162 +/- 18/107 +/- 9 to 145 +/- 18/95 +/- 8 mmHg, respectively; both P less than 0.001) the calf flow was not decreased at rest and after ischaemia. Resting resistance was not significantly reduced (from 49.5 +/- 35 to 38.9 +/- 33 mmHg/100 ml per min) but its fall was significantly correlated with the fall in mean blood pressure (rs = 0.35, P less than 0.05). These findings confirm that doxazosin may be useful in the treatment of hypertension complicated by peripheral artery disease.
authors.affiliation: Clinica Medica I, University of Padua, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Mozzato
authors.forename: F
authors.initials: F
authors.lastname: Buzzaccarini
authors.forename: P
authors.initials: P
authors.lastname: Casolino
authors.forename: R
authors.initials: R
authors.lastname: Valle
authors.forename: L
authors.initials: L
authors.lastname: Serena
authors.forename: N
authors.initials: N
authors.lastname: Rubino
authors.forename: E
authors.initials: E
authors.lastname: Casiglia
authors.forename: A
authors.initials: A
authors.lastname: Semplicini
authors.forename: A C
authors.initials: AC
authors.lastname: Pessina
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D017292:Doxazosin; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology
chemical_list: D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D017292:Doxazosin; D011224:Prazosin