Evolution time and longitudinal studies of the anti-S-antigen antibody titers in retinitis pigmentosa.
Sixty-six patients with retinitis pigmentosa (forma simplex) and 37 control patients were studied for titers of anti-S-antigen auto-antibodies by means of the enzyme-linked immunosorbent assay technique (ELISA). A longitudinal study showed a positive significance (P less than 0.01) which demonstrated the uniformity of the data obtained. Comparison of the anti-S-antigen titers of the patients and controls revealed a statistically significant difference (P less than 0.001) between both populations. The relationship between the time of evolution of retinitis pigmentosa and the anti-S-antigen titers also showed a statistically significant difference (P less than 0.005). These results show both a rise in the anti-S-antigen antibody titers in relation to the evolution time of retinitis pigmentosa and a uniformity in the data obtained in the anti-S-antigen antibody longitudinal study carried out.
Heredia García
C D
CD
Centro de Ottalmología Barraquer, Barcelona, Spain.
García Calderón
P A
PA
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000276:immunology*; D019393:Arrestin; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D004596:Electroretinography; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000276:immunology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000150:complications / Q000276:immunology*; D013997:Time Factors; D014794:Visual Fields
D000941:Antigens; D019393:Arrestin; D001323:Autoantibodies; D005136:Eye Proteins