title: [A comparative evaluation of methods for determining the glomerular filtration rate by 169Yb-DTPA clearance].
abstract: The authors present the results of comparative analysis of 7 radionuclide clearance methods for the determination of glomerular filtration rate (GFR), based on single administration of 169Yb-DTPC. A reference method was based on the determination of GFR by a curve of a decrease in plasma concentrations with subsequent biexponential analysis on a DVK-2M computer. Methods of the determination of GFR based on 2 blood drawing tests after achieving a uniform distribution of the indicator in its volume of dilution (1) and extracorporal labeling of gamma radiation by a precordial detector (2) showed the highest degree of correlation with the reference method (r = 0.918, p less than 0.001 and r = 0.920, p less than 0.001, respectively). The use of both methods based on a single-chamber model of renal clearance, led to good results, provided the measurements were to start not earlier than 1.5 h after administration of the indicator.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Kasatkin
authors.forename: E V
authors.initials: EV
authors.lastname: Shliakhto
authors.forename: I G
authors.initials: IG
authors.lastname: Kaiukov
authors.forename: I B
authors.initials: IB
authors.lastname: Dolgova
authors.forename: A A
authors.initials: AA
authors.lastname: Pushkarev
mesh_terms: D000293:Adolescent; D000328:Adult; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D004369:Pentetic Acid; D011868:Radioisotopes; D012588:Scintillation Counting / Q000295:instrumentation / Q000379:methods; D013997:Time Factors; D015018:Ytterbium
chemical_list: D011868:Radioisotopes; D004369:Pentetic Acid; D015018:Ytterbium
vernacular_title: Sravnitel'naia otsenka metodov opredeleniia skorosti klubochkovoĭ fil'tratsii po klirensu 169Yb-DTPK.