title: Synthesis of some 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazoles as potential anthelmintics.
abstract: Two novel series of triazolothiadiazole derivatives were synthesized, namely: 6-substituted-3-(4-substituted phenoxymethyl)-1,2,4-triazolo[3,4- b] [1,3,4]thiadiazoles and 6-mercapto-3-(4-substituted phenoxy-methyl)-1,2,4-triazolo[3,4- b] [1,3,4]thiadiazoles. The anthelmintic activity of representative compounds was studied.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
authors.forename: S M
authors.initials: SM
authors.lastname: el-Khawass
authors.forename: M A
authors.initials: MA
authors.lastname: Khalil
authors.forename: A A
authors.initials: AA
authors.lastname: Hazzaa
authors.forename: H A
authors.initials: HA
authors.lastname: Bassiouny
authors.forename: N F
authors.initials: NF
authors.lastname: Loutfy
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D013830:Thiadiazoles; D014230:Triazoles