title: [Antipyrogenic properties of oxytocin].
abstract: Effects of oxytocin on pyrogenal or endogenous pyrogen-induced fever were studied. Intramuscular injection of oxytocin (0.2 micrograms/kg every half an hour) did not significantly affect the pattern of pyrogenal-induced fever. Constant intravenous injection of oxytocin (0.4 and 4 micrograms/kg/h) 2-4.5 h after pyrogenal decreased the rectal temperature, on an average, by 24% and 31%, respectively. Endogenous pyrogen fever was not attenuated by intravenous oxytocin (4 micrograms/kg/h). The antipyrogenic effect of oxytocin is related to inhibition of endogenous pyrogen synthesis rather than to blockade of its action, which is indicated by a decreased second peak of the temperature curve, inhibition of endogenous pyrogen synthesis in vitro, and persistence of the hyperthermic effect of endogenous pyrogen.
authors.forename: P P
authors.initials: PP
authors.lastname: Murzenok
authors.forename: L F
authors.initials: LF
authors.lastname: Kutsaeva
authors.forename: T I
authors.initials: TI
authors.lastname: Zhitkevich
authors.forename: V N
authors.initials: VN
authors.lastname: Gurin
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005334:Fever / Q000188:drug therapy; D007273:Injections, Intramuscular; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011749:Pyrogens / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011817:Rabbits; D013997:Time Factors
chemical_list: D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D010121:Oxytocin
vernacular_title: Antipirogennye svoĭstva oksitotsina.