Time-course of corticosteroid-induced blood flow reduction in normal cutaneous tissue--quantitative measurements during 72 h of treatment.
In eight healthy individuals, the skin fold between the thumb and the forefinger was treated with 0.05% clobetasol propionate ointment under a hydrocolloid occlusive dressing. Using the atraumatic epicutaneous 133Xe wash-out technique on the outer 2 mm of the skin fold, covering the rest of the hand with a lead shield, we were able to monitor cutaneous blood flow. Blood flow was measured after 0, 10, 24, 48 and 72 h of treatment. During the first 10 h of treatment no significant change in blood flow was observed. However, compared to untreated tissue, cutaneous blood flow decreased significantly after a 24-h period (P less than 0.05). Furthermore a significant blood flow reduction from 0-48 (P less than 0.02) and from 0-72 h (P less than 0.01) was observed. Placebo did not decrease cutaneous blood flow, but a minor increase was demonstrated. The results of the present work demonstrate a long-lasting blood flow reducing effect of topical corticosteroid in normal human cutaneous tissue.
Petersen
L J
LJ
Kristensen
J K
JK
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013997:Time Factors; D014980:Xenon Radioisotopes
D000305:Adrenal Cortex Hormones; D014980:Xenon Radioisotopes