Copper(II)- and iron(II)-complexes of methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR investigation.
Methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a synthetic analogue of the chelating part of bleomycin (BLM), has been studied for its metal binding properties. Electron spin resonance parameters of AMPHIS-Cu(II) and BLM-Cu(II) have been found to be closely similar likewise spectra of oxygen radicals spin-adducts induced by AMPHIS-Fe(II)-O2 and BLM-Fe(II)-O2 systems. Thus, AMPHIS could constitute a very useful tool for the study of BLM mode of action.
Hénichart
J P
JP
Bernier
J L
JL
Houssin
R
R
Lohez
M
M
Kenani
A
A
Catteau
J P
JP
D001665:Binding Sites; D001761:Bleomycin; D002614:Chelating Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D004151:Dipeptides / Q000032:analysis / Q000138:chemical synthesis; D004578:Electron Spin Resonance Spectroscopy; D007501:Iron; D009942:Organometallic Compounds / Q000032:analysis / Q000138:chemical synthesis; D010100:Oxygen
D002614:Chelating Agents; D004151:Dipeptides; D009942:Organometallic Compounds; D001761:Bleomycin; D003300:Copper; C044370:copper(II)-methyl 2-(2-aminoethyl)aminoethylpyridine-6-carboxylhistidinate; C044371:iron(II)-methyl 2-(2-aminoethyl)aminomethylpyridine-6-carboxylhistidinate; D007501:Iron; D010100:Oxygen