[Chlordesmethyldiazepam and prolactinemia during surgical stress].
The per-operative plasma prolactin levels in 16 male patients undergoing plastic-reconstructive surgery were studied. 8 patients received chlordesmethyldiazepam 0.1 mg/kg-1 i.v. (group C), 8 sodium thiopental 5 mg/kg-1 i.v. (Group T) in anaesthesia induction. All patients were premedicated by diazepam 0.15 mg/kg-1 by mouth 90 min. before anaesthesia induction and atropine 0.007 mg/kg-1 i.v. just before induction, and received succinylcholine 1 mg/kg-1 i.v. and an endotracheal tube for mechanically controlled ventilation. Anaesthesia maintenance was assured by isoflurane 0.5-2.5% in a N2/O2 (2/1) gas mixture. Blood samples were collected from each patient at the following times; 24 h before surgery (t0); 30 min after skin incision (t1); 30 min after extubation (t2). Significant variation of blood prolactin levels are not been shown.
D'Eramo
C
C
I Servizio di Anestesia e Rianimazione, U.S.L. n. 4, Parma.
Tirelli
F
F
Maestri
D
D
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D003975:Diazepam / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011229:Preanesthetic Medication; D011388:Prolactin / Q000097:blood*; D013312:Stress, Physiological / Q000097:blood*; D013518:Surgery, Plastic; D013514:Surgical Procedures, Operative; D013874:Thiopental / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; D011388:Prolactin; D013874:Thiopental; C013434:chlordesmethyldiazepam; D003975:Diazepam
Clordemetildiazepam e prolattinemia in corso di stress chirurgico.