title: Atherosclerosis in uremic mice.
abstract: To study the possibility that susceptibility to the development of atherosclerosis during chronic renal failure is genetically determined, aortic lesion formation and changes in serum lipid levels in mice of 2 different inbred strains, C57BL/6J and A/J, were examined. Chronic uremia was induced by electrocoagulation of the right renal cortex and left nephrectomy. The mice were then fed either normal rodent chow or a saturated fat and cholesterol-enriched diet for 6 weeks. None of the A/J mice developed atherosclerosis, whereas the aortas of chow-fed uremic C57BL/6J mice were found to contain a number of fatty lesions, the severity of which was increased by a high fat diet. Uremia had different effects on serum cholesterol, triglycerides, and lipoproteins in the two strains. The results suggest that the resistance of A/J mice to uremia-induced atherosclerosis may be attributed to their ability to maintain high serum HDL-cholesterol levels and/or low serum triglyceride levels. The results further indicate that the development of atherosclerotic lesions in uremic mice is both genetically determined and affected by diet.
authors.affiliation: Montreal General Hospital Research Institute, Quebec, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Stewart-Phillips
authors.forename: R F
authors.initials: RF
authors.lastname: Gagnon
authors.forename: J
authors.initials: J
authors.lastname: Lough
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood; D004036:Diet, Atherogenic; D005260:Female; D007676:Kidney Failure, Chronic / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014511:Uremia / Q000097:blood*
chemical_list: D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol