[Changes in lipid peroxidation and the antioxidative system of the myocardium in adrenaline-induced damage of the heart].
Epinephrine-induced cardiac injury (ECI) was simulated in rabbits. The indices of the system of peroxidation of lipids (LPO) and antioxidants were examined during various periods (3 hours, 3 and 9 days) of ECI. It was found that lower lipid antioxidative activity of blood, i.e. weaker body's antiperoxide protection, was found most early, then there was higher malonic dialdehyde (MDA) (a marker of thromboxane, TBA2) generation. The increase in antiperoxidase protection occurred at the level of the target organ (heart). There was a rise in the activity of the antioxidative enzyme superoxide dismutase and inhibited formation of primary products of LPO such as dien conjugates from early to 9 hours of the observation. When the natural antioxidant alpha-tocopherol was given prior to ECI, it prevented enhanced MDA formation in the platelets, optimized prostacyclin synthesis in the vascular wall, and stabilized blood lipid antioxidative activity.
Aliev
M A
MA
Bekbolotova
A K
AK
Kostiuchenko
L S
LS
Lemeshenko
V A
VA
D000818:Animals; D000975:Antioxidants; D009202:Cardiomyopathies / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D004195:Disease Models, Animal; D004837:Epinephrine; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D004837:Epinephrine
Izmenenie perekisnogo okisleniia lipidov i antioksidantnoĭ sistemy miokarda pri adrenalinovom povrezhdenii serdtsa.