title: [Assessment of the relation between bone mineral metabolism and mitral annular calcification or aortic valve sclerosis in elderly patients].
abstract: We assessed the effect of bone mineral metabolism on mitral annular calcification (MAC) and aortic valve sclerosis (AVS) in elderly patients. Both MAC and AVS were derived by 2-D echocardiography and bone mineral content (BMC) of vertebral body was obtained by quantitative computed tomography using a calibrated phantom system. The 162 patients were classified according to the echocardiographic finding into three groups; CNT group consisted of the 79 control patients (31 males, 48 females) without MAC or AVS. MAC group: 42 patients (11 males, 31 females) with MAC, and AVS group: 41 patients (19 males, 22 females) with AVS. The results were as follows: 1) The incidence of MAC and AVS in both males and females were increased in proportion to aging. 2) The incidence of MAC in females (31%) was higher than that of males (18%). 3) The AVS in males (31%) was more frequent than that in females (22%). 4) In females of eighth and ninth decades, the BMC in MAC group was significantly decreased than that in CNT group, but not different in males. 5) In both males and females, the BMC in AVS group was not significantly different from that in CNT group. These results suggest that the MAC may be attributed to the ectopic deposit, probably related to the de-calcification from the spinal bone. On the other hand, the AVS may be caused by the other factors, mainly prolonged and sustained pressure or stress loading.
authors.forename: N
authors.initials: N
authors.lastname: Sugihara
authors.forename: K
authors.initials: K
authors.lastname: Furutani
authors.forename: M
authors.initials: M
authors.lastname: Miyawaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Makino
authors.forename: M
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: T
authors.initials: T
authors.lastname: Wakiyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D002114:Calcinosis / Q000209:etiology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology*; D012598:Sclerosis
chemical_list: D002118:Calcium