title: [In vitro detection of ovalbumin-specific IgA producing cells from lymphocytes of patients with hen-egg allergy].
abstract: We studied antigen-specific IgA production from the peripheral lymphocytes of children with hen-egg allergy by using the method of indirect plaque forming cell (PFC) assay. The number of OVA-specific IgA-PFC generated from the patient lymphocytes was low (6 +/- 3/7 X 10(4) non T cells) in comparison with age-matched normal children (112 +/- 18/7 X 10(4) non T cells). The numbers of OVA-specific IgG-PFC and IgM-PFC generated from the patient lymphocytes were not so different from those of the age-matched normal children. This indicates that the activity of OVA-specific IgA-antibody production was reduced in patients with hen-egg allergy.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Noma
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: J
authors.initials: J
authors.lastname: Yata
mesh_terms: D002675:Child, Preschool; D004531:Eggs; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M; D010047:Ovalbumin