title: A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100).
abstract: Seventeen patients with advanced Parkinson's disease who had fluctuations in motor performance while taking standard Sinemet (STD) 25/100 underwent daylong pharmacokinetic and clinical observation studies while taking both STD and Sinemet CR, a new controlled-release formulation containing 50 mg carbidopa and 200 mg levodopa. During treatment with Sinemet CR, there was an increase in the interdose interval, a reduction in the number of medication doses taken each day, an increase in total "on" time, and a reduction in the number of "off" episodes. Total daily levodopa intake was greater with Sinemet CR, although the bioavailability of levodopa and carbidopa from the two preparations was equivalent. The variability in plasma levodopa levels was significantly less with Sinemet CR. The slower release of drug from Sinemet CR was reflected in a prolongation of the Tmax for levodopa and a prolongation of the interval from Tmax to the succeeding trough levodopa level. Clinically, peak antiparkinsonian effect occurred later and lasted longer with the CR preparation.
authors.affiliation: Department of Neurology, Cornell University Medical College, White Plains, NY.
authors.forename: J M
authors.initials: JM
authors.lastname: Cedarbaum
authors.forename: H
authors.initials: H
authors.lastname: Kutt
authors.forename: F H
authors.initials: FH
authors.lastname: McDowell
mesh_terms: D000978:Antiparkinson Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D002230:Carbidopa / Q000493:pharmacokinetics* / Q000494:pharmacology; D004338:Drug Combinations / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy*; D014443:Tyrosine / Q000097:blood / Q000031:analogs & derivatives
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D014443:Tyrosine; D007980:Levodopa; D002230:Carbidopa; C008404:3-methoxytyrosine