title: [Factors affect Na(+)-Ca2+ exchange in rat's cardiomyocytes and protein-reconstituted liposomes].
abstract: Rat's Ca-resistant ventricular myocytes and reconstituted liposomes of canine cardiac sarcolemma were used in analysing factors affecting Na(+)-Ca2+ exchange system. Decrease in extracellular (extravesicular) Na+ or increase in intracellular Na+ by inhibition of the Za(+)-K(+)-ATPase with ouabain stimulated the Na(+)-Ca2+ exchange. Mn2+, an antagonist of Na(+)-Ca2+ exchange, dose-dependently inhibited the Na(+)-dependent Ca2+ uptake. However, verapamil had no effect on it. Arachidonic acid and lipid peroxides caused by incubation with-H2O2 significantly stimulated Na(+)-Ca2+ exchange in a dose-dependent fashion.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Li
authors.forename: C S
authors.initials: CS
authors.lastname: Tang
authors.forename: J Y
authors.initials: JY
authors.lastname: Su
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D007474:Ion Exchange; D008081:Liposomes / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*
chemical_list: D001095:Arachidonic Acids; D008081:Liposomes; D012964:Sodium; D002118:Calcium