[Results of antineoplastic chemotherapy based on the oncobiogram].
An organ culture assay for in vitro chemosensitivity testing was used to predict clinical responses of various tumors to antineoplastic chemotherapy. 9 patients with advanced mammary carcinomas, 7 patients with metastatic malignant melanomas, 1 patient with advanced ovarian cancer, 1 with bronchogenic carcinoma, 1 with metastatic leiomyosarcoma and 1 patient with a metastatic carcinoma of the sweat gland were included in the study. 20 in vitro-in vivo correlations were evaluable. 5/9 of the mammary carcinomas showed an objective response, 0/7 malignant melanomas were sensitive in vivo. Further investigations have to assess the value of chemosensitivity assays to predict clinical response for patients with solid tumors.
Ebert
A
A
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Lenk
H
H
Geyer
J
J
Tanneberger
S
S
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008545:Melanoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D011379:Prognosis
D000970:Antineoplastic Agents
Ergebnisse einer antineoplastischen Chemotherapie nach Onkobiogramm.