title: Bioavailability of suckable tablets of oral N-acetylcysteine in man.
abstract: The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
authors.affiliation: Istituto di Farmacologia Medica II, Università degli Studi di Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Bernardi di Valserra
authors.forename: G
authors.initials: G
authors.lastname: Mautone
authors.forename: E
authors.initials: E
authors.lastname: Barindelli
authors.forename: P
authors.initials: P
authors.lastname: Lualdi
authors.forename: F
authors.initials: F
authors.lastname: Feletti
authors.forename: M R
authors.initials: MR
authors.lastname: Galmozzi
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004339:Drug Compounding; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013607:Tablets
chemical_list: D013607:Tablets; D000111:Acetylcysteine