Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat.
The antithrombinic activity of some naturally occurring omega-oxygenated derivatives of ferulenol and ferprenin has been tested. On the basis of these results, both the type of the oxygenated function and the stereochemistry of the terminal double bond seem important for the biological activity.
Tagliapietra
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Dipartimento di Scienza e Tecnologia del Farmaco, Torino, Italy.
Aragno
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Ugazio
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Nano
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GM
D000818:Animals; D000925:Anticoagulants; D003374:Coumarins / Q000302:isolation & purification* / Q000633:toxicity; D008297:Male; D010947:Plants, Toxic / Q000032:analysis*; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014859:Warfarin / Q000494:pharmacology
D000925:Anticoagulants; D003374:Coumarins; D014859:Warfarin