Hypotensive and peripheral vascular effects in healthy volunteers of repeated oral administration of pinacidil.
The hypotensive and peripheral vascular effects of two different oral formulations of pinacidil were investigated in twelve healthy male volunteers. Arterial blood pressure, heart rate and calf blood flow were measured on Days 1 and 7. The vasodilator activity of both formulations was confirmed by a significant increase in calf blood flow on both days, which was correlated with a significant decrease in diastolic blood pressure. There was no differences between the tablet and the pellet.
Saumet
J L
JL
Laboratoire de Physiologie et d'Explorations Fonctionelles, CHRU, Angers, France.
Dubois
F
F
Girard
P
P
Geloen
A
A
Boissel
J P
JP
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D020110:Pinacidil; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects*
D006146:Guanidines; D020110:Pinacidil