title: Transfer of experimental allergic neuritis with P2-reactive T-cell lines.
abstract: Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.
authors.forename: A
authors.initials: A
authors.lastname: Rostami
authors.forename: J B
authors.initials: JB
authors.lastname: Burns
authors.forename: M J
authors.initials: MJ
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Rosen
authors.forename: B
authors.initials: B
authors.lastname: Zweiman
authors.forename: R P
authors.initials: RP
authors.lastname: Lisak
authors.forename: D E
authors.initials: DE
authors.lastname: Pleasure
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D002460:Cell Line; D007116:Immunization, Passive; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000941:Antigens; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein