[The effect of functionally bound vitamins and their coenzyme forms on the activity of 2-oxoacid dehydrogenases in mouse organs].
Ever-growing doses (beginning from the therapeutic up to 10-fold doses of a complex of five functionally bound vitamins (B1, FMN, nicotinamide, pantothenate, lipoic acid) being administered to F1 mice (CBA x Black) induced a constant and considerable rise of the pyruvate- and 2-oxoglutarate dehydrogenase (PDG and OGDG) activity in the mouse organs. In the in vitro experiments the addition of the corresponding coenzymes or their mixture (in the optimal concentrations) to the incubation medium containing mitochondria of the mouse liver led to a greater activation of these dehydrogenases in the group of animals which were preliminary injected the above complex of vitamins.
Karpov
L M
LM
Polesia
T L
TL
D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D000818:Animals; D001921:Brain / Q000201:enzymology; D003067:Coenzymes / Q000494:pharmacology*; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D008808:Mice, Inbred CBA; D009097:Multienzyme Complexes / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D014815:Vitamins / Q000494:pharmacology*
D003067:Coenzymes; D009097:Multienzyme Complexes; D011768:Pyruvate Dehydrogenase Complex; D014815:Vitamins; D007658:Ketone Oxidoreductases; D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Deĭstvie funktsional'no sviazannykh vitaminov i ikh kofermentnykh form na aktivnost' degidrogenaz 2-oksokislot v organakh mysheĭ.