Influence of food-intake during a fixed period on hydrocortisone-induced relapse of acetic acid ulcers in rats.
We studied the influence of food-intake during a fixed period on hydrocortisone-induced relapse of acetic acid ulcers in rats. The ulcer index, the defective area of the ulcerated region and the exposure index for the ulcer floor in the food-intake-time limited group markedly increased as compared to those in the control group. The index for the regenerated mucosa decreased in the food-intake-time limited group. Thus, hydrocortisone-induced relapsed ulcers were markedly increased by limiting the food-intake-time.
Ito
M
M
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Tanaka
T
T
Suzuki
Y
Y
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D004435:Eating; D005753:Gastric Mucosa / Q000473:pathology; D006854:Hydrocortisone; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012008:Recurrence; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D000085:Acetates; D019342:Acetic Acid; D006854:Hydrocortisone