Nd:YAG laser modulation of synovial tissue metabolism.
In studies designed to establish the safety and efficacy of laser treatment of arthritis, the in vitro effect of Nd:YAG laser radiation on normal, osteoarthritic and rheumatoid synovial tissue and synovial fibroblast metabolism has been addressed. Defined energy levels of normal pulsed radiation (TEMoo mode) consistently up-regulated synovial tissue explant culture hyaluronic acid and protein synthesis. In contrast, high intensity Q-switched delivery down-regulated the response. The application of normal pulsed radiation had a variable effect on synovial fibroblast synthesis but the response of any given cell isolate was consistent. DNA synthesis and cell viability were not affected.
Herman
J H
JH
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267.
Khosla
R C
RC
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis; D007834:Lasers; D010003:Osteoarthritis / Q000378:metabolism*; D014176:Protein Biosynthesis; D013583:Synovial Membrane / Q000378:metabolism* / Q000528:radiation effects
D006820:Hyaluronic Acid; D004247:DNA