Inhibitory effect of cyclosporin A on histamine release from human leukocytes and rat mast cells.
The influence of cyclosporin A (CyA) on human basophil histamine release induced in vitro by specific antigen, anti-IgE, calcium ionophore A23187, or concanavalin A (Con A) was studied. CyA inhibited the release induced by these four stimulators. It is suggested that the drug acts directly on the target cell, since similar effect was obtained with isolated peritoneal rat mast cells. The basophil histamine release was not changed by a non-immunosuppressive cyclosporin derivate.
Pedersen
C
C
Permin
H
H
Stahl Skov
P
P
Norn
S
S
Svenson
M
M
Mosbech
H
H
Bendtzen
K
K
D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000276:immunology; D003524:Cyclosporins / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins