Serum procollagen III peptide in alcoholic and other chronic liver diseases.
Increased levels of serum procollagen III peptide (P-III-P) have been found in patients with alcoholic hepatitis and cirrhosis. Serum P-III-P was increased (greater than 15 micrograms/l) in 38 of 44 (86%) patients with alcoholic liver cirrhosis, in 6 of 20 (30%) with fatty liver, in 1 of 13 (8%) with non-alcoholic fatty liver, and in 3 of 14 (21%) with other chronic liver diseases. Median serum P-III-P was almost three times higher in alcoholic liver cirrhosis than in alcoholic fatty liver (p less than 0.001). Serum P-III-P was increased in three of six patients with alcoholic fatty liver and periportal fibrosis. In the total material (n = 91), a statistically significant negative correlation between serum P-III-P and albumin (r = -0.71, p less than 0.001) and Normotest (r = -0.63, p less than 0.001), respectively, and a positive correlation between serum P-III-P and bilirubin (r = 0.65, p less than 0.001) were found. The serum level of P-III-P had no prognostic value concerning the mortality in patients with alcoholic cirrhosis.
Bell
H
H
Dept. of Medicine, Aker University Hospital, Oslo, Norway.
Raknerud
N
N
Orjasaeter
H
H
Haug
E
E
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D005234:Fatty Liver / Q000097:blood* / Q000378:metabolism; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000378:metabolism; D005260:Female; D006519:Hepatitis, Alcoholic / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood / Q000378:metabolism; D008113:Liver Neoplasms / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis
D007136:Immunoglobulins; D012709:Serum Albumin; D001663:Bilirubin