title: Investigation of a test system for the rapid differentiation of nuclear and cytoplasmic damage in eucaryotes.
abstract: The effect of various agents which cause cell inactivation on the growth curves and RNA synthesis rates of yeast cells has been studied. On the basis of these investigations it was concluded that such studies can be used as a rapid test system for drawing preliminary conclusions as to whether a particular agent primarily damages the DNA of the cell nucleus or cytoplasmic structures.
authors.forename: W
authors.initials: W
authors.lastname: Ehrlich
authors.forename: M
authors.initials: M
authors.lastname: Mangir
authors.forename: E R
authors.initials: ER
authors.lastname: Lochmann
authors.forename: R
authors.initials: R
authors.lastname: Nischt
authors.forename: P
authors.initials: P
authors.lastname: Bradish
mesh_terms: D000181:Acrylonitrile / Q000633:toxicity; D002104:Cadmium / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects*; D002477:Cells / Q000166:cytology*; D003593:Cytoplasm / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology* / Q000528:radiation effects; D007700:Kinetics; D012313:RNA / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000166:cytology; D012977:Sodium Nitrite / Q000633:toxicity; D014466:Ultraviolet Rays
chemical_list: D002104:Cadmium; D012313:RNA; D004247:DNA; D012977:Sodium Nitrite; D000181:Acrylonitrile