Linkage of the mouse LDL receptor gene on chromosome 9.
We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.
Frank
S L
SL
Department of Microbiology, University of California, Los Angeles 90024.
Taylor
B A
BA
Lusis
A J
AJ
D000818:Animals; D015139:Blotting, Southern; D002875:Chromosomes; D003433:Crosses, Genetic; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D009710:Nucleotide Mapping; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics*; D011995:Recombination, Genetic
D005819:Genetic Markers; D011973:Receptors, LDL