title: [Effects of somatostatin peridurally administered in the treatment of postoperative pain].
abstract: Somatostatin (SMS), a hormone extensively found within the CNS, has shown to have a powerful analgesic effects administered either via the epidural or subdural route. The aim of the present study was to evaluate the efficacy of SMS administered epidurally compared with placebo, for the treatment of post-operative pain in patients receiving epidural anaesthesia for surgery. Of the 86 patients observed, 58 entered the study and were randomized to receive either SMS or placebo in a double blind fashion. They were also divided into 3 groups according to the site of the operation (group A: procto-anal; group B: inguino-crural; group C: other), 28 of them receiving SMS and 30 placebo. The post-operative pain evaluation was obtained via VAS at the moment of request of treatment (basal) and after an hour. Twenty-eight of the 86 observed (32.5%) didn't complain of pain that necessitated analgesic treatment. A statistically significant difference in reduction of intensity of pain was observed in the somatostatin treated group (6.42 +/- 0.37 vs 3.64 +/- 0.59) and in the somatostatin treated subgroup A and B (6.4 +/- 0.4 vs 3.8 +/- 0.7 and 6.3 +/- 0.8 vs 3.0 +/- 0.6 respectively). No adverse reactions of any kind were observed. SMS has shown to be a safe and effective drug, reducing by 50% the intensity of pain in patients undergone procto-anal or inguino-crural surgery.
authors.forename: M
authors.initials: M
authors.lastname: Bagarani
authors.forename: C
authors.initials: C
authors.lastname: Amodei
authors.forename: P
authors.initials: P
authors.lastname: Beltramme
authors.forename: P
authors.initials: P
authors.lastname: Contadini
authors.forename: A
authors.initials: A
authors.lastname: Pacifici
authors.forename: A
authors.initials: A
authors.lastname: Terenzi
authors.forename: G
authors.initials: G
authors.lastname: Venuto
authors.forename: F
authors.initials: F
authors.lastname: Toti
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013004:Somatostatin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D013004:Somatostatin
vernacular_title: Effetti della somministrazione della somatostatina per via peridurale nel trattamento del dolore post-operatorio.