Kinetic properties of the plasma membrane Na+-H+ exchanger.
The plasma membrane Na+-H+ exchanger is a ubiquitous transport system that participates in diverse cell functions involving the cellular uptake of Na+ or extrusion of H+. It has a tightly coupled 1:1 stoichiometry, has affinity for Li+ and NH+4 in addition to Na+ and H+, and can function in multiple amiloride-sensitive exchange modes involving these cations. These general transport properties may be explained by kinetic models involving either cation-hydroxyl cotransport or actual cation-proton exchange. The most important kinetic property of the Na+-H+ exchanger is its greater than first-order dependence on [H+]i. This property enables the Na+-H+ exchanger to play an important role in the regulation of intracellular pH.
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D000818:Animals; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000378:metabolism; D007474:Ion Exchange; D007700:Kinetics; D008956:Models, Chemical; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D013816:Thermodynamics
D002352:Carrier Proteins; D007473:Ion Channels; D011522:Protons; D017923:Sodium-Hydrogen Exchangers