The influence of amikacin on digoxin uptake by certain rabbit tissues in vitro.
The influence of amikacin on digoxin uptake by various rabbit tissues was investigated in vitro. 125J-digoxin was used and radioactivity was counted in a gamma scintillation counter. Amikacin decreases digoxin uptake by the renal tissue and this action is probably due to a displacing effect. On the contrary, amikacin increases digoxin uptake by striated and cardiac muscle. It is suggested that the latter action is due to a vasodilating effect of the aminoglycoside antibiotic that favors the microcirculation of the above tissues.
Kokkas
B
B
Department of Pharmacology, Medical Faculty, Aristotelian University, Thessaloniki, Greece.
Kotoula
M
M
Kouyoumtzis
A
A
Paradelis
A G
AG
D000583:Amikacin / Q000494:pharmacology*; D000818:Animals; D004077:Digoxin / Q000378:metabolism* / Q000493:pharmacokinetics; D005260:Female; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D004077:Digoxin; D000583:Amikacin