title: Synthesis of 9 alpha-hydroxysteroids by a Rhodococcus sp.
abstract: 9 alpha-Hydroxylation of delta 5-3 beta-hydroxysteroids (of androstane, pregnane, 24-nor- and 21,24-bisnorcholane groups) was carried out by a Rhodococcus sp., isolated from a petroleum-containing soil sample. A large number of the investigated steroids was transformed into 9 alpha-hydroxy-delta 4-3-ketones in satisfactory yields (50-90%) at high initial concentrations of the substrates (0.5-5.0 g/L). The influence of some structural features of the steroid molecule on the progress and effectiveness of the microbial transformation was also shown.
authors.affiliation: Institute of Organic Chemistry with Centre of Phyto-Chemistry, Bulgarian Academy of Sciences, Sofia.
authors.forename: V K
authors.initials: VK
authors.lastname: Datcheva
authors.forename: N E
authors.initials: NE
authors.lastname: Voishvillo
authors.forename: A V
authors.initials: AV
authors.lastname: Kamernitskii
authors.forename: R J
authors.initials: RJ
authors.lastname: Vlahov
authors.forename: I G
authors.initials: IG
authors.lastname: Reshetova
mesh_terms: D000731:Androstanes / Q000378:metabolism; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006900:Hydroxylation; D006914:Hydroxysteroids / Q000378:metabolism*; D011278:Pregnanes / Q000378:metabolism; D012240:Rhodococcus / Q000378:metabolism*
chemical_list: D000731:Androstanes; D006914:Hydroxysteroids; D011278:Pregnanes