Linkage of the Dao-1 gene for D-amino-acid oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5.
Linkage of the Dao-1 gene controlling D-amino-acid oxidase to the Pgm-1 gene controlling phosphoglucomutase-1 on the mouse chromosome 5 was examined. Mutant ddY/DAO- mice carrying a null Dao-1c allele had a Pgm-1a allele. Mutant mice were crossed to C3H/HeN and NZB/Kl mice carrying the Dao-1+ and Pgm-1b alleles. The hybrid F1 mice were backcrossed to the ddY/DAO- and their progeny were examined for alleles for D-amino-acid oxidase and phosphoglucomutase-1. In both backcrosses, the progeny with recombinant-type combinations of the alleles were significantly less than the progeny with the parental-type combinations, indicating the linkage of the Dao-1 and Pgm-1 genes. The recombination frequency between these loci was estimated to be 19.8 +/- 4.0%.
Konno
R
R
Department of Microbiology, Dokkyo University School of Medicine, Tochigi.
Niwa
A
A
Yasumura
Y
Y
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003605:D-Amino-Acid Oxidase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D010733:Phosphoglucomutase / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic
D007527:Isoenzymes; D003605:D-Amino-Acid Oxidase; D010733:Phosphoglucomutase