[Intra-tubal embryo transfer (IVF/IT-ET) in the treatment of non-tubal-induced sterility. Initial studies of the value of a new and expensive therapy procedure].
Intratubar embryo transfer is a form of sterility treatment, in which the in-vitro-fertilized pre-implantation embryos are transferred into the intact fallopian tube(s). This enables the benefits of in-vitro fertilization (information of the gamete fertilization behavior, specific incubation of dysmature oocytes, reduction of the polyploidy rate, risk of multiple pregnancies) to be combined with those of gamete intrafallopian transfer (GIFT; tubar environment for the further development of the pre-implantation embryos). Intratubar embryo transfer is indicated in cases of sterility that are not due to the fallopian tubes; in addition to idiopathic sterility, particular emphasis is put on a certain form of immunological sterility (antibodies against sperm antigens), which seems to be a special indication for this method. Intratubar embryo transfer demands a two sided approach. It is advisable to collect the oocytes transvaginally, guided by ultrasound, since general anaesthesia maybe dispensed with - if so desired. The embryo transfer itself still requires a pelviscopy, which is only performed once fertilization of the oocyte has been confirmed; which is in contrast to GIFT, in which pelviscopy is an inherent part of each treatment cycle. In spite of this advantage, intratubar embryo transfer is a method, which is associated with a high expenditure. The aim of the study was, to evaluate the success rate when all the alternative, less costly options have been exhausted. Our first results are demonstrating, that intratubar embryo transfer is successful, even as a second line therapy. Therefore the method has a significance in the treatment of sterility, not caused by the tubes and the expenditure, with which it is associated, can be justified.(ABSTRACT TRUNCATED AT 250 WORDS)
Würfel
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Frauenklinik Dr. Krüsmann, München.
Krüsmann
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Hirsch
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Rothenaicher
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Krüsmann
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D000328:Adult; D004624:Embryo Transfer / Q000191:economics / Q000379:methods*; D047108:Embryonic Development; D005186:Fallopian Tube Patency Tests; D005187:Fallopian Tubes; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005500:Follow-Up Studies; D015181:Gamete Intrafallopian Transfer / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D011247:Pregnancy; D011272:Pregnancy, Multiple
Der intratubare Embryotransfer (IVF/IT-ET) in der Behandlung der nicht tubar bedingten Sterilität. Erste Untersuchungen zur Stellung eines neuen und aufwendigen Therapieverfahrens.