[Anti-necrosogenic action of natural and synthetic antioxidants in coronary occlusive myocardial infarct].
The synthetic liposoluble antioxidant BAT. 120 mg/kg, was found to produce markedly protective effects in a rat model of coronary occlusive myocardial infarction, whereas the water soluble BAT analogue, 4-Oxy-3,5-ditretbutylphenyl phosphonic acid sodiate (SFN-6), 100 mg/kg, displayed no protective effects. The natural antioxidant beta-carotene capable of displaying antioxidative activity at low partial O2 pressures was shown to reduce the size of postinfarct scar by 34% when given in a dose of 20 mg/kg. The synthetic antioxidants, BAT and SFN-6 given in doses of 100 to 120 mg/kg each decreased antioxidant enzyme activities in the intact or infarct-related myocardium. beta-carotene was found to lack inhibitory effects on the myocardial antioxidant enzymes, thus enhancing its cardioprotective properties.
Konovalova
G G
GG
Lankin
V Z
VZ
Vakulova
L A
LA
Kukhareva
T S
TS
Vikhert
A M
AM
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D019207:beta Carotene
D000975:Antioxidants; D019207:beta Carotene; D002338:Carotenoids
Antinekrozogennoe deĭstvie prirodnykh i sinteticheskikh antioksidantov pri koronarookkliuzionnom infarkte miokarda.