[The first cycle of DNA replication in parthenogenetic mouse embryos].
Dynamics of the first cell cycle in parthenogenetic mouse embryos derived from ethanol-activated eggs was studied using 3H-thymidine. DNA synthesis starts within 5 h and is terminated within 10 h after activation: it lasts ca. 6 h. Changes in the intensity of 3H-thymidine incorporation and in the distribution of radioactive label between haploid and diploid parthenogens were observed. 3H-thymidine was shown to incorporate into pronucleoli of diploid parthenogens and late-labeled heterochromatin blocks were bound in both diploid and haploid pronuclei. The structure of the first cell cycle in parthenogenetic and normal embryos is discussed.
Severova
E L
EL
Samoshkina
N A
NA
Dyban
A P
AP
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects / Q000502:physiology*; D004171:Diploidy; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006238:Haploidy; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010312:Parthenogenesis / Q000187:drug effects / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D000431:Ethanol; D004247:DNA; D013936:Thymidine
Izuchenie pervogo tsikla replikatsii DNK u partenogeneticheskikh zarodysheĭ mysheĭ.