Effect of interscapular brown adipose tissue denervation on body weight and feed efficiency in alcohol drinking rats.
In rats, chronic alcohol intake increases energy expenditure and enhances interscapular brown adipose tissue (IBAT) mass and activity. It is known that alcohol intake is mainly preprandial. In man, alcohol intake during a meal increases postprandial thermogenesis. Since diet-induced thermogenesis is mediated by the sympathetic nervous system, the effect of IBAT surgical denervation was examined on body weight (BW), food intake (FI) and feed efficiency (FE) in alcohol drinking rats. Alcohol drinking rats gained significantly less BW than water drinking rats; FI was identical and so FE was less in alcohol-treated animals. After sympathectomy, the water drinking group was identical to its own control group for BW gain, FI and FE. BW gain of sympathectomized drinking rats was significantly higher than that of controls. FI and FE were nearly identical. It is concluded that the increase in thermogenesis observed in chronic alcohol-treated rats is partly suppressed by sympathectomy. This increase could also involve other BAT mass and other tissues in the whole rat.
Larue-Achagiotis
C
C
Laboratoire Neurobiologie de la Nutrition, Université Pierre et Marie Curie, Paris, France.
Poussard
A M
AM
Louis-Sylvestre
J
J
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology*; D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy
D000431:Ethanol