Putative mesothelial cell growth-promoting activity of a cytoplasmic protein expressed by the mesothelial cell. A preliminary report.
Mesothelioma cells produce a cytoplasmic protein unique to primary tumours of the mesothelium which induces the in vitro proliferation of human mesothelial cells in a dose-dependent fashion. When a polyclonal antibody to this protein was added to cultures of human mesothelioma cells, inhibition of their growth occurred. These results provide evidence for a growth-factor-like role of this mesothelial protein that may act through an autocrine mechanism.
Donna
A
A
Department of Pathology, City Hospital, Alessandria, Italy.
Betta
P G
PG
Cosimi
M F
MF
Robutti
F
F
Bellingeri
D
D
Marchesini
A
A
D002455:Cell Division / Q000187:drug effects; D004848:Epithelium / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008654:Mesothelioma / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000378:metabolism*
D006133:Growth Substances; D007106:Immune Sera