Prenatal sex determination by DNA amplification from maternal peripheral blood.
The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.
Lo
Y M
YM
University of Oxford Clinical School.
Patel
P
P
Wainscoat
J S
JS
Sampietro
M
M
Gillmer
M D
MD
Fleming
K A
KA
D001769:Blood; D005260:Female; D005333:Fetus; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012732:Sex Determination Analysis; D014998:Y Chromosome
D005819:Genetic Markers