title: [Drugs in secondary prevention of ischemic heart disease: achievements, problems and prospects].
abstract: The paper provides critical reviews of the progress made in the past 25 years in studies on long-term drug prophylaxis of coronary heart disease. Particular attention is given to general problems, including those in the application of three major groups of antianginal agents, namely, nitrates, beta-adrenoblockers, and calcium antagonists to the prolonged secondary prevention of the disease. It has been shown that there is every prospects of future studies in this area. A general conclusion is drawn from a number of investigations performed at the Preventive Pharmacological Department, All-Union Cardiology Research Center, and in the All-Union Research Center of Preventive Medicine, USSR Ministry of Health over the past 5 years. These involve methodologically complicated matters of choice and long-term usage of drugs, including antianginal drugs within the collaborative studies.
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D009248:Nadolol / Q000627:therapeutic use; D009543:Nifedipine / Q000627:therapeutic use; D009566:Nitrates / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D009566:Nitrates; D009248:Nadolol; D011433:Propranolol; D014700:Verapamil; D005996:Nitroglycerin; D008790:Metoprolol; D009543:Nifedipine; D007548:Isosorbide Dinitrate
vernacular_title: Medikamentoznaia vtorichnaia profilaktika ishemicheskoĭ bolezni serdtsa: dostizheniia, problemy i perspektivy.