The major histocompatibility complex and insulin dependent (type 1) diabetes.
The majority of the genetic component in insulin dependent (Type 1) diabetes mellitus can be explained by associations with genes on short arm of chromosome 6 located in the major histocompatibility complex. With the advent of cloning of the HLA Class II region genes it has been possible to refine the previous known association of HLA-DR3 and DR4 with this disease. Strong associations of IDDM have now been shown to exist with the DQB1 gene and/or linked genes, although this does not completely explain the HLA susceptibility to this disease.
Hitman
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GA
Medical Unit, London Hospital, Whitechapel.
D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D012150:Polymorphism, Restriction Fragment Length
D006680:HLA Antigens; D006684:HLA-DR Antigens; D004247:DNA