[Effect of buyang huanwu decoction on the antithrombotic functions of the vessel wall].
The effects of Buyang Huanwu Decoction (BYHWD) on the antithrombotic functions of vessel wall were studied with human umbilical vein perfusion. It was observed that the both of Von Willebrand factor release stimulated by thrombin from the vessel walls and conversion of fibrinogen to fibrin catalyzed by thrombin were inhibited by BYHWD. There were no obvious effects of BYHWD on the thrombin adsorption to the vessel walls and the thrombin induced release of PGI2 as well as fibrinolysis inhibiting activity from the vessel walls.
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D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents; D006801:Humans; D011486:Protein C / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D011486:Protein C; D013917:Thrombin