Induction of self-tolerance in mature peripheral B lymphocytes.
In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.
Goodnow
C C
CC
Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.
Crosbie
J
J
Jorgensen
H
H
Brink
R A
RA
Basten
A
A
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004790:Enzyme Induction; D007108:Immune Tolerance / Q000276:immunology*; D007072:Immunoglobulin D / Q000378:metabolism; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009113:Muramidase / Q000096:biosynthesis / Q000235:genetics; D011961:Receptors, Fc; D011971:Receptors, Immunologic / Q000235:genetics; D015032:Zinc / Q000494:pharmacology
D007072:Immunoglobulin D; D007075:Immunoglobulin M; D011961:Receptors, Fc; D011971:Receptors, Immunologic; C050855:immunoglobulin D receptor; D009113:Muramidase; D015032:Zinc