Hyperglycemia may determine fibrinopeptide A plasma level increase in humans.
The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italy.
Giugliano
D
D
Quatraro
A
A
Dello Russo
P
P
Marchi
E
E
Torella
R
R
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D005344:Fibrinopeptide A / Q000032:analysis*; D005934:Glucagon / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D007262:Infusions, Intravenous; D008297:Male; D013917:Thrombin / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D005344:Fibrinopeptide A; D005340:Fibrinogen; D006493:Heparin; D005934:Glucagon; D013917:Thrombin; D005947:Glucose