A new cell surface molecule closely related to mouse class I transplantation antigens.
The "37" H-2 class I mouse gene, located in the Tla complex, is poorly polymorphic and is transcribed in a wide variety of cells and tissues. Using antisera directed against peptides deduced from the gene sequence, we demonstrate that the 37 gene encodes a 45.5-kDa cell surface glycoprotein. This protein, initially identified on the surface of mouse L cells transfected with an overexpressing 37 gene, is present on cells such as splenocytes of various mouse strains except those of A/J mice. Thus, mouse cells may express not only the major transplantation antigens encoded by the K and D region genes, but at least one additional poorly polymorphic class I molecule encoded by the 37 gene.
Cochet
M
M
Unité de Biologie Moléculaire du Gène, U.277 INSERM, UAC 115 CNRS, Institut Pasteur, Paris, France.
Casrouge
A
A
Dumont
A M
AM
Transy
C
C
Baleux
F
F
Maloy
W L
WL
Coligan
J E
JE
Cazenave
P A
PA
Kourilsky
P
P
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D007106:Immune Sera / Q000276:immunology; D007739:L Cells / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D011233:Precipitin Tests; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection
D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; D007106:Immune Sera