Equivalent inhibition by terbutaline of anti-human IgE skin responses in atopic and non-atopic subjects.
Previous studies have shown that pretreatment of skin with beta 2-adrenoceptor stimulants antagonizes anti-human IgE elicited wheal and flare reactions in atopic and non-atopic subjects. This experimental system was employed to further study the hypothesis that atopic disease and bronchial asthma unrelated to atopy might be associated with a beta-adrenoceptor defect. Eight patients with extrinsic and 10 patients with intrinsic asthma deprived of oral bronchodilator treatment and corticosteroids for at least a week, and in a clinically stable condition, 10 patients with extrinsic rhinitis and on no treatment, as well as age and sex matched healthy control subjects showed almost identical dose-response relations for the inhibitory effect of intradermally injected terbutaline (0.25-100 ng), on anti-IgE elicited skin reactions. In four asthmatic patients the inhibitory effect of terbutaline did not change following a treatment period with oral terbutaline and theophylline. The data do not support the presence of a cutaneous mast cell beta 2-adrenoceptor defect in patients with atopy or bronchial asthma unrelated to atopy.
Grönneberg
R
R
Strandberg
K
K
Stålenheim
G
G
Zetterström
O
O
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001249:Asthma / Q000276:immunology; D003864:Depression, Chemical; D003888:Desensitization, Immunologic; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013726:Terbutaline / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D000888:Antibodies, Anti-Idiotypic; D011943:Receptors, Adrenergic, beta; D007073:Immunoglobulin E; D013726:Terbutaline