title: Evaluation of nickel complexes of bioligands-effect on distribution profile.
abstract: Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation is subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.
authors.affiliation: Toxicokinetic Division, Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: R C
authors.initials: RC
authors.lastname: Srivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: M
authors.initials: M
authors.lastname: Athar
authors.forename: S K
authors.initials: SK
authors.lastname: Hasan
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009532:Nickel / Q000493:pharmacokinetics*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D008024:Ligands; D006639:Histidine; D009532:Nickel; D005978:Glutathione