title: Physiological antagonism between prostaglandin E2 and neuropeptide Y on thermoregulation in the dog.
abstract: These experiments were undertaken to determine whether neuropeptide Y (NPY) could suppress a prostaglandin hyperthermia in conscious dogs. Prostaglandin E2 (PGE2) (5 micrograms), injected into the lateral cerebral ventricle (ILV), evoked a hyperthermia of approximately 1 degrees C. Addition of ILV NPY (5 micrograms) significantly attenuated the PGE2-induced hyperthermia, whereas pancreatic polypeptide (PP), another member of the PP family peptide, did not. These results provide evidence for a role of NPY on thermoregulation in the dog.
authors.affiliation: Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Inui
authors.forename: H
authors.initials: H
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Okita
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Sakatani
authors.forename: M
authors.initials: M
authors.lastname: Oya
authors.forename: H
authors.initials: H
authors.lastname: Hatanaka
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Oimomi
authors.forename: S
authors.initials: S
authors.lastname: Baba
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004285:Dogs; D007276:Injections, Intraventricular; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology
chemical_list: D009478:Neuropeptide Y; D015232:Dinoprostone