Rapid recovery of Echinococcus granulosus following 'successful' albendazole therapy in a gerbil model.
Peritoneal Echinococcus granulosus in gerbils was treated with albendazole. Both early and late infections were studied; response to albendazole therapy and the ability of the parasite to recover after treatment was found to depend on dose and length of therapy. Even after treatment at 50 mg/kg for 2 months late infections retained the ability to recover over 3 months.
Taylor
D H
DH
Department of Surgery, University Hospital, Nottingham, UK.
Richards
K S
KS
Morris
D L
DL
D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus / Q000187:drug effects / Q000302:isolation & purification*; D005849:Gerbillinae
D015766:Albendazole