title: Curative resection of multiple gastrinomas aided by selective arterial secretin injection test and intraoperative secretin test.
abstract: Recently a number of surgeons have recommended radical resection of gastrinomas in Zollinger-Ellison syndrome (ZES). We have developed a useful technique for preoperative localization of gastrinomas--the selective arterial secretin injection test (SASI)--and we recommend an intraoperative secretin test (IOS) for deciding the radicality of resection of gastrinomas. Here the results of SASI and IOS tests in 11 patients with ZES are examined and compared with the results of other techniques. The SASI test localized gastrinomas in all of the patients, while the sensitivity of ultrasonography, computed tomography, arteriography, or portal venous blood samplings was between 1/11 and 5/11. On the basis of the results of the SASI test, radical resection of gastrinoma was performed in four patients (three pancreatoduodenectomies and one extirpation). After pancreatoduodenectomy, immunohistologic study of the specimen revealed multiple microgastrinomas and lymph node metastases in two patients and the coexistence of a microgastrinoma and a gastinoma in one patient. The IOS test was useful in the estimation of the advisability of radicality, and in two patients total gastrectomy was not performed because of the results of the IOS test. These four patients are well and have returned to work, and their serum gastrin levels are below 35 pg/mL. Thus we believe SASI and IOS tests are helpful for planning curative resection of gastrinomas.
authors.affiliation: Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Isobe
authors.forename: Y
authors.initials: Y
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Satomura
authors.forename: T
authors.initials: T
authors.lastname: Tobe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015408:Gastrinoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007269:Injections, Intra-Arterial; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012633:Secretin; D015043:Zollinger-Ellison Syndrome / Q000601:surgery*
chemical_list: D012633:Secretin