[An experimental study of the ocular hypotensive action of dopaminergic antagonists].
The ocular hypotensive action of a group of dopaminergic antagonists was observed in the low intraocular pressure model of albino rabbits infused with 20% NaCl. It was found that haloperidol lowered IOP significantly in both eyes, though the drug was administered in one eye. Compared with timolol and pilocarpine, the strength in lowering IOP was in the order haloperidol greater than timolol greater than pilocarpine. Haloperidol did not affect the pupil. It may be a promising antiglaucoma agent.
Xia
X P
XP
D000818:Animals; D018492:Dopamine Antagonists; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits; D013999:Timolol / Q000494:pharmacology
D018492:Dopamine Antagonists; D010862:Pilocarpine; D013999:Timolol; D006220:Haloperidol