title: Genetic markers of the antigen-specific T cell receptor locus.
abstract: The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen-specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell.
authors.forename: R
authors.initials: R
authors.lastname: Epstein
authors.forename: N
authors.initials: N
authors.lastname: Roehm
authors.forename: P
authors.initials: P
authors.lastname: Marrack
authors.forename: J
authors.initials: J
authors.lastname: Kappler
authors.forename: M
authors.initials: M
authors.lastname: Davis
authors.forename: S
authors.initials: S
authors.lastname: Hedrick
authors.forename: M
authors.initials: M
authors.lastname: Cohn
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D000939:Epitopes; D008040:Genetic Linkage; D005819:Genetic Markers; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007144:Immunoglobulin J-Chains / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D000939:Epitopes; D005819:Genetic Markers; D007127:Immunoglobulin Constant Regions; D007144:Immunoglobulin J-Chains; D011948:Receptors, Antigen, T-Cell; D004262:DNA Restriction Enzymes