Prefrontal cortex gating of auditory transmission in humans.
Middle-latency auditory evoked potentials (MAEPs) were recorded in controls and patients with focal lesions in dorsolateral prefrontal cortex. Unilateral prefrontal lesions increased the amplitude of the Pa component of the MAEP beginning at 25-35 ms poststimulus. The data suggest that prefrontal cortex exerts early inhibitory modulation of input to primary auditory cortex in humans.
Knight
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Department of Neurology, University of California, Davis Veterans Administration Medical Center, Martinez 94553.
Scabini
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Woods
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D000161:Acoustic Stimulation; D000368:Aged; D001306:Auditory Pathways / Q000502:physiology*; D001309:Auditory Threshold; D005072:Evoked Potentials, Auditory; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology