Genetic hemochromatosis: distribution analysis of six laboratory measures of iron metabolism.
Six laboratory measures of iron metabolism were studied in a control sample, and a family sample was ascertained on the basis of probands with clinically diagnosed genetic hemochromatosis. The respective distribution of each variable evidenced a mixture of components, presumably arising from the segregation of an HLA-linked locus for hemochromatosis. There were significant differences in the distributional characteristics with respect to sex and genotype-specific variances. These aspects of the data have important implications for subsequent segregation and linkage analyses, which traditionally assume homoscedasticity and homogeneity of the genetic effect.
Borecki
I B
IB
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110.
Rao
D C
DC
Le Mignon
L
L
Yaouanq
J
J
Simon
M
M
Lalouel
J M
JM
D003676:Deferoxamine; D005260:Female; D005293:Ferritins / Q000097:blood; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006432:Hemochromatosis / Q000097:blood / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D012737:Sex Factors; D012984:Software; D014168:Transferrin / Q000032:analysis
D006680:HLA Antigens; D014168:Transferrin; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine