[Anti H2 receptors and perforated peptic ulcer. Review of 442 cases].
H2 blockers have accelerated the reduction in elective peptic ulcer surgery but appear to have had no equivalent effect on the incidence of perforated ulcer success. A 13 year (1975-1987) review of perforated peptic ulcer is presented. The mean annual number of operations for perforation fell from 8.21% to 4.93% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged. A significant reduction was found in mean annual rates for perforated duodenal ulcer from 6.86% to 3.82% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged.
Mastroianni
V
V
Calgaro
M
M
Manfredi
S
S
Manzini
R
R
Bevilacqua
S
S
D015331:Cohort Studies; D004381:Duodenal Ulcer / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010439:Peptic Ulcer Perforation / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
D006635:Histamine H2 Antagonists
Anti H2 recettori e ulcera peptica perforata. Revisione di 442 casi.