title: Gross genetic differences among substrains of NZB mice.
abstract: Substrains of NZB mice have been compared by Southern blot analysis using several probes. The restriction fragment length polymorphism of probes derived from the Igh-V, Igk-V, Tcr alpha-C loci and of the long terminal repeat of the mouse mammary tumour virus revealed that NZB/BlLwPtIbm were grossly different from NZB/BlNJ and NZB/BlOla. Comparison with mouse strains of the Igk-V haplotypes a and d suggested that NZB/BlLwPtIbm contain genetic material of the C58 mouse strain.
authors.affiliation: Basel Institute for Immunology, Basel, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Weiss
authors.forename: Y
authors.initials: Y
authors.lastname: Uematsu
authors.forename: L
authors.initials: L
authors.lastname: D'Hoostelaere
authors.forename: A
authors.initials: A
authors.lastname: Alanen
mesh_terms: D000818:Animals; D005803:Genes, Immunoglobulin / Q000235:genetics; D006239:Haplotypes; D008099:Liver / Q000032:analysis; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000276:immunology; D008815:Mice, Inbred Strains / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D013045:Species Specificity
chemical_list: D011948:Receptors, Antigen, T-Cell