[Opioid peptides, regulators of acetylcholinesterase activity].
Studies have been made on the opioid peptides--enkephalins their fragments, and alpha- and gamma-endorphins with concentrations of 10(-8)-10(-4) M, on acetylcholinesterase of human blood erythrocytes. It was found out that these peptides, which were fragments of one propeptide beta-LPH were reversible effectors of acetylcholinesterase. Enkephalins and a number of their fragments were noncompetitive inhibitors. It was shown that natural pentapeptide has the highest inhibitor activity; decreasing of inhibitor activity or the absence of it was a result of pentapeptide molecules degradation. Short endorphins were noncompetitive activators of acetylcholinesterase.
Muranevich
S A
SA
Polosatov
M V
MV
D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004723:Endorphins / Q000502:physiology*; D004745:Enkephalins / Q000502:physiology; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans
D002800:Cholinesterase Inhibitors; D004723:Endorphins; D004745:Enkephalins; D000110:Acetylcholinesterase
Opioidnye peptidy--reguliatory aktivnosti atsetilkholinésterazy.