title: Fibrous bodies in growth hormone-secreting adenomas contain cytokeratin filaments.
abstract: Fibrous bodies in growth hormone-secreting adenomas were studied by immunocytochemistry using an anti-cytokeratin antiserum. Fibrous bodies are a feature of acidophil and chromophobe adenomas and are usually associated with acromegaly. Ultrastructural examination revealed round juxtanuclear filamentous aggregates, composed of 8-nm filaments and other organelles. This study demonstrated that the intermediate filaments of fibrous bodies belong to the cytokeratin class. The etiology and significance of these filamentous aggregates remain obscure.
authors.forename: P E
authors.initials: PE
authors.lastname: Neumann
authors.forename: J E
authors.initials: JE
authors.lastname: Goldman
authors.forename: D S
authors.initials: DS
authors.lastname: Horoupian
authors.forename: M A
authors.initials: MA
authors.lastname: Hess
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D009940:Organoids / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D007633:Keratins; D013006:Growth Hormone