title: Opiate dependence alters central reward of nalbuphine or pentazocine plus tripelennamine.
abstract: The threshold lowering effects of the coadministration of tripelennamine plus nalbuphine or tripelennamine plus pentazocine on the threshold for rewarding electrical intracranial stimulation, a model of drug-induced euphoria, was determined in rats physically dependent to morphine. Although tripelennamine plus nalbuphine had threshold-lowering effects similar to tripelennamine plus pentazocine in non-opiate-dependent subjects, tripelennamine plus nalbuphine failed to lower the threshold for rewarding stimulation in morphine-dependent animals. To the extent that these data may be applied to human addicts, it suggests that opiate-dependent addicts are unlikely to use the combination of tripelennamine plus nalbuphine but are likely to use tripelennamine plus pentazocine.
authors.affiliation: Boston University School of Medicine, Laboratory of Behavioral Pharmacology, MA 02118.
authors.forename: D
authors.initials: D
authors.lastname: Huston-Lyons
authors.forename: G T
authors.initials: GT
authors.lastname: Bain
authors.forename: C
authors.initials: C
authors.lastname: Kornetsky
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009266:Nalbuphine / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000523:psychology*; D010423:Pentazocine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012201:Reward; D014309:Tripelennamine / Q000494:pharmacology*
chemical_list: D009019:Morphinans; D014309:Tripelennamine; D009266:Nalbuphine; D010423:Pentazocine