title: The domain model for eukaryotic DNA organization. 2: A molecular basis for constraints on development and evolution.
abstract: A model for eukaryotic DNA organization has been proposed in which DNA regulatory processes depend on multiple site-specific DNA-nuclear matrix interactions throughout a DNA domain. In this model gene regulation depends on combinations of a few control factors in a cell to activate cell type-specific genes. This model suggests simple molecular mechanisms for organismal development which can account for sequential activation of appropriate groups of genes throughout development and for specific constraints on developmental pathways. Additionally, these suggested developmental pathways are consistent with mechanisms of evolution in which gradualism and punctuated equilibrium are not exclusive of one another and are interrelated mechanisms of evolution that are both induced by specific chromosomal mutations.
authors.affiliation: Department of Biology, Northeastern University, Boston, Massachusetts 02115.
authors.forename: J W
authors.initials: JW
authors.lastname: Bodnar
authors.forename: G S
authors.initials: GS
authors.lastname: Jones
authors.forename: C H
authors.initials: CH
authors.lastname: Ellis
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D008957:Models, Genetic; D009154:Mutation; D014158:Transcription, Genetic
chemical_list: D004247:DNA