Bradykinin action in the rat duodenum: Ca2(+)-dependent effects of bradykinin on the activity of particulate guanylate cyclase.
The nonapeptide bradykinin has been found to exert opposite effects on cGMP synthesis in a plasma membrane fraction from the rat duodenum. In the absence of exogenous Ca2+ BK increased the activity of the duodenal particulate guanylate cyclase which is decreased, in contrast, in a medium containing 1 mM exogenous Ca2+. In a Ca2(+)-free medium, on the other hand, both BK effects are completely prevented. The results suggest a presumable role of pGC in BK signal transmission in the rat duodenum with calcium ions as a mediator and/or essential cofactor.
Liebmann
C
C
Department of Biology, Friedrich-Schiller University, GDR, Jena.
Roemer
W
W
Reissmann
S
S
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006152:Cyclic GMP / Q000096:biosynthesis; D004386:Duodenum / Q000187:drug effects* / Q000201:enzymology; D006162:Guanylate Cyclase / Q000378:metabolism*; D051381:Rats
D006162:Guanylate Cyclase; D006152:Cyclic GMP; D001920:Bradykinin; D002118:Calcium