Delayed maturation of the antibody response to type 2 thymus-independent antigens in a partially inbred strain of chicken.
The ontogeny of antibody responses to trinitrophenylated (TNP) thymus-independent (TI) antigens was compared in two partially inbred strains of chicken: the SC strain (B2/B2 genotype) and the FP strain (B15/B22 genotype). In the SC chicken, maturation of both the splenic anti-TNP plaque-forming cell (PFC) response and the 19S hemagglutinating antibody response to TI type 2 (TI-2) antigens, TNP-Ficoll and TNP-dextran, were delayed to a significantly later time in ontogeny (20 wk of age) than in the FP chickens (9 wk of age). Four- to 6-wk-old SC chickens were virtually immunologically unresponsive to stimulation with TI-2 antigens. The TI-1 antigen TNP-Brucella abortus was equally immunogenic in both FP and SC chickens of different age groups tested. Kinetic studies of the primary PFC response to TNP-Ficoll in immunologically mature chickens of the SC and FP strains demonstrated a peak PFC response 4 days after antigen injection, followed by a rapid decline in numbers of splenic PFC/spleen on day 6. The results of these studies are discussed in relation to earlier observations that suggested there may be a delay or a defect in the ontogeny of the thymus in the SC chicken.
Goidl
E A
EA
Theis
G A
GA
D000375:Aging; D000818:Animals; D000921:Antibody-Producing Cells / Q000378:metabolism / Q000502:physiology*; D000955:Antigens, T-Independent / Q000008:administration & dosage / Q000276:immunology*; D002645:Chickens / Q000254:growth & development / Q000276:immunology*; D003911:Dextrans / Q000008:administration & dosage / Q000276:immunology; D005362:Ficoll / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007700:Kinetics; D013154:Spleen / Q000166:cytology; D014301:Trinitrobenzenes / Q000008:administration & dosage / Q000276:immunology
D000955:Antigens, T-Independent; D003911:Dextrans; C020529:TNP-ficoll; D014301:Trinitrobenzenes; D005362:Ficoll