Erythrocyte sodium and potassium transport systems during longterm administration of the diuretic xipamide in men.
The effects of xipamide on the intracellular concentration and transmembrane fluxes of Na+ and K+ were studied in twenty-four normal sodium-replete or -deplete male subjects, using a double-blind study design. After a run-in period on placebo for 1 week on their regular diet, subjects were treated on their regular diet or on a low-sodium diet with either placebo or xipamide 20 mg once a day for 16 weeks. Intra-erythrocyte Na+ concentration was increased during xipamide administration in sodium-replete and deplete subjects, while intra-erythrocyte K+ and total intraleukocyte Ca2+ concentrations were decreased. Red cell Na+, K+-cotransport activity was lower in xipamide-treated subjects, while Na+, Li-countertransport activity was increased. No significant effect of xipamide could be demonstrated on ouabain-sensitive 86Rb-uptake or on maximal [3H]-ouabain binding in erythrocytes.
Lijnen
P
P
Department of Pathophysiology, University of Leuven, Belgium.
Amery
A
A
D000328:Adult; D001693:Biological Transport, Active / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004311:Double-Blind Method; D004912:Erythrocytes / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012044:Regression Analysis; D012964:Sodium / Q000097:blood*; D014988:Xipamide / Q000494:pharmacology*
D004232:Diuretics; D002034:Bumetanide; D014988:Xipamide; D010042:Ouabain; D012964:Sodium; D011188:Potassium