Exacerbation of adenomyosis symptomatology by estrogen-progestin therapy: a case report and histopathological observations.
The present case report illustrates the hormonal sensitivity of adenomyosis. Administration of an estrogen-progestin combination for what was felt to be symptomatic endometriosis resulted in exacerbation of symptoms and growth of adenomyomas. Histopathologic examination of the hysterectomy specimen revealed a pattern of decidualization previously unreported, but consistent with current theories of experimental in vivo and in vitro decidua formation.
Falk
R J
RJ
Department of Pathology, Columbia Hospital for Women Medical Center, Washington, D.C.
Mullin
B R
BR
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D004715:Endometriosis / Q000139:chemically induced* / Q000473:pathology; D005040:Ethynodiol Diacetate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000139:chemically induced* / Q000473:pathology; D008656:Mestranol / Q000009:adverse effects*; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014599:Uterus / Q000473:pathology
D003277:Contraceptives, Oral, Combined; D005040:Ethynodiol Diacetate; C018467:Bisecurin I; D008656:Mestranol