Stoichiometry of net sodium and potassium fluxes mediated by the Na-K-Cl co-transport system in ferret red cells.
The bumetanide-sensitive Na-K-Cl co-transport system in ferret red cells produces net movement of 1Na:1K. Tracer studies have misleadingly suggested a stoichiometry of 2Na:1K probably because the transporter mediates substantial Na-Na exchange in these cells.
Flatman
P W
PW
Department of Physiology, University Medical School, Edinburgh.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology; D002335:Carnivora / Q000097:blood*; D002352:Carrier Proteins / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005289:Ferrets / Q000097:blood*; D008297:Male; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D028021:Sodium-Potassium-Chloride Symporters
D002352:Carrier Proteins; D028021:Sodium-Potassium-Chloride Symporters; D002034:Bumetanide; D012964:Sodium; D011188:Potassium