A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion.
We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored.
Friedman
S
S
Sillcocks
D
D
Rao
A
A
Faas
S
S
Cantor
H
H
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000950:Antigens, Ly / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D002999:Clone Cells / Q000145:classification / Q000276:immunology; D000939:Epitopes; D005260:Female; D006649:Histocompatibility Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007700:Kinetics; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010950:Plasma Cells / Q000166:cytology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*; D013997:Time Factors
D000950:Antigens, Ly; D000939:Epitopes; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D007074:Immunoglobulin G