Intestinal absorption of stearic acid after consumption of high fat meals in humans.
The intestinal absorption of stearic acid (18:0), relative to other fatty acids, was evaluated in a group of 10 normal volunteers. Subjects were fed two types of high fat meals; one contained a relatively high content of stearic acid and the other a relatively low content. Plasma chylomicrons were isolated at 2, 4, 6 and 8 h after ingestion of the meals. Fatty acid patterns of chylomicron lipids were determined, and relative intestinal absorption rates of each fatty acid were estimated by comparing the fatty acid composition of chylomicron lipids with that of the fat in the meals. Overall, for both meals the fatty acid pattern of chylomicron lipids was very similar to that of ingested fat. Percentages of palmitic acid (16:0) and stearic acid, relative to other fatty acids, were only slightly lower in chylomicron lipids than in the meal fat. These data suggest that intestinal absorbability of stearic acid is similar to that of palmitic acid, and both saturated fatty acids appear to be absorbed almost as well as oleic acid (16:1).
Bonanome
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A
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052.
Grundy
S M
SM
D000328:Adult; D000704:Analysis of Variance; D002914:Chylomicrons / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005215:Fasting; D006801:Humans; D007408:Intestinal Absorption; D008055:Lipids / Q000097:blood; D008297:Male; D013229:Stearic Acids / Q000493:pharmacokinetics*
D002914:Chylomicrons; D004041:Dietary Fats; D008055:Lipids; D013229:Stearic Acids