The sequence of the A gamma globin gene in a G gamma beta+ type of hereditary persistence of fetal haemoglobin.
The sequence of the A gamma globin gene from the affected chromosome of an individual heterozygous for the G gamma beta+ type of hereditary persistence of fetal haemoglobin (G gamma beta+ HPFH) is reported. With two exceptions, it is identical to one of the two allelic A gamma globin genes already sequenced and there is therefore no change which could explain the absence of its expression in the face of the persistent G gamma globin expression which is a feature of this condition.
Jones
R W
RW
Goodbourn
S E
SE
Old
J M
JM
Weatherall
D J
DJ
D000483:Alleles; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
D005914:Globins; D005319:Fetal Hemoglobin; D004262:DNA Restriction Enzymes