Pregnenolone sulfate antagonizes barbiturate-induced hypnosis.
The potential influence of the neurosteroid pregnenolone sulfate (PrS) on barbiturate-induced hypnosis was tested in rats. PrS, when injected intracerebroventricularly or intraperitoneally, significantly shortened the sleep-time produced by pentobarbital. The results suggest an important physiological and pharmacological role for PrS in the regulation of CNS excitability.
Majewska
M D
MD
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Bluet-Pajot
M T
MT
Robel
P
P
Baulieu
E E
EE
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006991:Hypnosis, Anesthetic; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D011284:Pregnenolone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
C018370:pregnenolone sulfate; D011284:Pregnenolone; D010424:Pentobarbital