title: Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients.
abstract: Using a full length cystatin C cDNA probe and the Alu I restriction enzyme a total of 33 patients with senile dementia, Alzheimer type and 31 Down's syndrome patients have been investigated for the presence of the 630 bp Alu I restriction fragment length polymorphism in the cystatin C gene detected in Icelandic patients with hereditary cystatin C amyloid angiopathy. Results showed that all the patients had normal cystatin C fragment length of 600 bp.
authors.affiliation: Blood Bank, National Hospital, Reykjavik.
authors.forename: A
authors.initials: A
authors.lastname: Palsdottir
authors.forename: L
authors.initials: L
authors.lastname: Thorsteinsson
authors.forename: S
authors.initials: S
authors.lastname: Jonsdottir
authors.forename: A
authors.initials: A
authors.lastname: Arnason
authors.forename: J
authors.initials: J
authors.lastname: Snaedal
authors.forename: T
authors.initials: T
authors.lastname: Magnusson
authors.forename: E
authors.initials: E
authors.lastname: Snorrason
authors.forename: R
authors.initials: R
authors.lastname: Ingibergsdottir
authors.forename: M
authors.initials: M
authors.lastname: Abrahamson
authors.forename: I
authors.initials: I
authors.lastname: Olafsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis*; D015342:DNA Probes; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007055:Iceland; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D015342:DNA Probes; D005819:Genetic Markers