Serum fatty acid profiles after intravenous medium chain triglyceride administration.
The serum fatty acid profiles of patients receiving either intravenous medium or long chain triglycerides were studied. Seventeen hospitalized patients, dependent on total parenteral nutrition, were randomly enrolled into a prospective study. The total parenteral nutrition (TPN) delivered amino acids and glucose and either a 75% medium chain triglyceride and 25% long chain triglyceride (MCT group) physical mixture or all long chain triglyceride (LCT group), as the respective fat sources. The amino acids and glucose were given continuously, and the lipid was given for 10 hours each day over five days. Fatty acid profiles on serum triglycerides and free fatty acids were done in the morning before any lipid was given and also later in the afternoon, near the end of the lipid administration, on days 1, 3 and 5. Medium chain fatty acids rose quickly in the triglyceride fraction in patients given MCT. Rapid MCT hydrolysis occurred as evidenced by the appearance of medium chain fatty acids in the free fatty acid fraction in the afternoon sampling. Clearance of the hydrolyzed medium chain free fatty acids (MCFFA) occurred so that little, if any, were present in the morning sampling one day later. Long chain fatty acids, as either triglycerides or free fatty acids, showed expected increases during the daily infusion, but not of such relative magnitude as the medium chain fatty acids. Medium chain fatty acid incorporation into the phospholipid or cholesterol ester fractions by the end of the five-day feeding period was present but minimal.(ABSTRACT TRUNCATED AT 250 WORDS)
Mascioli
E A
EA
Department of Medicine, Harvard Medical School, New England Deaconess Hospital, Boston, MA.
Lopes
S
S
Randall
S
S
Porter
K A
KA
Kater
G
G
Hirschberg
Y
Y
Babayan
V K
VK
Bistrian
B R
BR
Blackburn
G L
GL
D000328:Adult; D000368:Aged; D001095:Arachidonic Acids / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D003652:Decanoic Acids / Q000097:blood; D004032:Diet; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008041:Linoleic Acids / Q000097:blood; D008042:Linolenic Acids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000097:blood; D010169:Palmitic Acids / Q000097:blood; D010743:Phospholipids / Q000097:blood; D013229:Stearic Acids / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage*
D001095:Arachidonic Acids; D002788:Cholesterol Esters; D003652:Decanoic Acids; D005227:Fatty Acids; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D010743:Phospholipids; D013229:Stearic Acids; D014280:Triglycerides