[Participation of small RNAs, associated with poly(A)+RNA in cytoplasm in hormonal regulation of genome expression].
The fraction of small RNA (sacc-RNA), associated with cytoplasmic rat liver poly(A)+RNA by non-covalent, possibly complementary interactions, has been isolated and studied. Fingerprint analysis data reveal that the specific changes occur in the population of sacc-RNA in response to glucocorticoid treatment. The close similarity of oligonucleotide composition of sacc-RNA and RNA-component of small nuclear RNP-acceptor of glucocorticoid hormones has been found. The tightly boynd peptides were observed in the fraction of sacc-RNA. The hypothesis of the involvement of the small RNA in the hormonal regulation at post-transcriptional stages of gene expression in the cytoplasm has been forward.
Konstantinova
I M
IM
Petukhova
O A
OA
Kulichkova
V A
VA
Volkova
I V
IV
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000235:genetics; D006728:Hormones / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D009710:Nucleotide Mapping; D009841:Oligonucleotides / Q000032:analysis; D011061:Poly A / Q000235:genetics*; D012342:RNA, Small Nuclear / Q000235:genetics* / Q000302:isolation & purification; D051381:Rats
D005938:Glucocorticoids; D006728:Hormones; D009841:Oligonucleotides; D012342:RNA, Small Nuclear; D011061:Poly A
Uchastie malykh RNK, assotsiirovannykh s poli(A)+-tsitoplazmy, v gormonal'noĭ reguliatsii ékspressii genoma.