[Two cases of Graves' disease with anti-thyroid hormone autoantibodies: the effect of subtotal thyroidectomy on the titers of anti-thyroid hormone autoantibodies and anti-Tg antibodies].
We experienced two cases of Graves' disease associated with anti-thyroid hormone autoantibodies (Case 1: anti-T4, Case 2: anti-T3). Both cases underwent subtotal thyroidectomy, and titers of anti-thyroid hormone antibodies and anti-Tg antibodies were compared before and after operation. In case 1, titers of both anti-T4 and anti-Tg antibodies decreased after operation, whereas in Case 2, titers of both anti-T3 and anti-Tg were unchanged before and after operation. There was a significant positive correlation between titers of anti-T4 and anti-Tg antibodies in Case 1 (r = 0.90, P less than 0.01), and anti-T3 and anti-Tg antibodies in Case 2 (r = 0.64, P less than 0.01). These results strengthen the possibility that the antigen of anti-thyroid hormone autoantibodies in both cases is the Tg molecule.
Nagai
K
K
Department of Internal Medicine, Takayama Red Cross Hospital.
Maekawa
H
H
Kametani
M
M
Tokimitsu
N
N
Komaki
T
T
Kojima
N
N
Sakata
S
S
D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006111:Graves Disease / Q000276:immunology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology*; D013963:Thyroid Hormones / Q000276:immunology*; D013965:Thyroidectomy
D001323:Autoantibodies; D013963:Thyroid Hormones; D013954:Thyroglobulin