[A biorhythmologic approach to evaluating forced swimming as an experimental model of a "depressive" state].
Rhythmical structure of forced swimming was studied on rats. Reserpine (1 mg/kg, 24 h before testing), clonidine (150 mkg/kg) and prolonged repeated striatal stimulation induced behavioural depression with reorganization of swimming rhythm and increase of short cycles (less than 6 s) of immobility. After chronic administration of antidepressants (imipramine, amitriptyline, niamid, 10 mg/kg/day, during 14 days), on the contrary, the number of these cycles diminished, while the number of active swimming cycles increased. Chrono-biological "index of depression" is suggested to express more exactly behavioural depression and specific activity of antidepressants than usual registration of immobility time.
Shchetinin
E V
EV
Baturin
V A
VA
Arushanian
E B
EB
Ovanesov
K B
KB
Popov
A V
AV
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D003863:Depression / Q000209:etiology* / Q000503:physiopathology; D003864:Depression, Chemical; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010507:Periodicity; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013550:Swimming; D013997:Time Factors
D000928:Antidepressive Agents
Bioritmologicheskiĭ podkhod k otsenke prinuditel'nogo plavaniia kak éksperimental'noĭ modeli "depressivnogo" sostoianiia.