Inhibition of clastogenic effect of radiation by Liv. 52 in the bone marrow of mice.
The frequency of micronuclei in bone marrow cells of mice treated or not with Liv. 52 and then exposed to 4.5 Gy of gamma-radiation was evaluated from 6 h to 14 days post irradiation. The frequency of micronuclei increased from 6 h to 24 h post irradiated in both irradiated groups and declined thereafter, the frequency of micronuclei remaining significantly lower in the Liv. 52-treated group. These data demonstrate that Liv. 52 protects the bone marrow of mice against radiation injury.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, India.
Ganapathi
N G
NG
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D004338:Drug Combinations / Q000494:pharmacology; D005720:Gamma Rays; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D013997:Time Factors
D004338:Drug Combinations; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C002614:Liv 52