Altered lymphocyte proliferation by low dosage laser irradiation.
The effect of gallium-aluminum-arsenide laser irradiation on the proliferation of human lymphocytes in culture in response to mitogenic stimulation by phytohemagglutinin was investigated. Mitogenic proliferation was inhibited by the laser irradiation at a low energy fluence and enhanced at a high energy fluence. The results indicate that low-watt laser irradiation can interfere with the immune response in vitro, and similar interference could occur in patients with rheumatoid arthritis subjected to laser therapy, if an appropriate dosage is chosen.
Inoue
K
K
Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Japan.
Nishioka
J
J
Hukuda
S
S
D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D006801:Humans; D007834:Lasers; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D010835:Phytohemagglutinins
D010835:Phytohemagglutinins; D004247:DNA