Roles of intoxicated practice in the development of ethanol tolerance.
The development of tolerance to the motor impairment effect of ethanol was examined in separate groups of rats receiving and not receiving intoxicated practice. Tolerance to the motor impairment effect of ethanol developed whether or not rats received intoxicated practice during chronic ethanol treatment. Depending on the treatment dosage and test dose, intoxicated practice might enhance the level of tolerance attained. Tolerance to other effects of ethanol (hypothermia and narcosis) developed as a function of the treatment dosage. Intoxicated practice on the moving belt did not modify the development of tolerance to these effects of ethanol. Tolerance to the motor impairment effect of ethanol, however, was retained much longer in the intoxicated practice group following the termination of ethanol treatment.
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Addiction Research Foundation of Ontario, Toronto, Canada.
Kalant
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Khanna
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D000435:Alcoholic Intoxication / Q000523:psychology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D011214:Practice, Psychological; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol