Diagnosis, management, and pathogenetic studies in medullary thyroid carcinoma syndrome.
A retrospective study of 224 patients with medullary thyroid carcinoma (MTC) diagnosed between 1963 and 1988 was performed to 1) establish the diagnosis of MTC in early childhood, 2) establish the role of prophylactic regional lymphadenectomy in patients with MTC, 3) study the effect of chemotherapy on MTC patients with metastatic disease, 4) study the effect of somatostatin analog 201-995 (Sandoz Pharmaceuticals) on the frequency of diarrhea in MTC, and 5) locate the common region(s) of gene deletion on chromosome 1 and examine the loss of heterozygosity on chromosome 10 in tumors. Our data indicated that a progressive rise of serum calcitonin in early childhood (rather than the expected fall with age seen in normal subjects) is diagnostic of MTC. No differences in clinical course of prognosis were observed between patients with MTC localized to the thyroid who had prophylactic neck node dissection and those who did not. Conventional chemotherapy had no significant benefit in the treatment of patients with metastatic disease. The somatostatin analog was found to be an effective drug in the treatment of diarrhea associated with MTC. Allelic losses were frequently found in MTCs and pheochromocytomas, and the loss of DNA sequences in these tumors appeared to involve the distal third of the short arm of chromosome 1, with a common breakpoint at 1p32.
Samaan
N A
NA
Yang
K P
KP
Schultz
P
P
Hickey
R C
RC
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D000328:Adult; D002116:Calcitonin / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D003131:Combined Modality Therapy; D015342:DNA Probes; D005260:Female; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D010673:Pheochromocytoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D013965:Thyroidectomy
D015342:DNA Probes; D002116:Calcitonin