The kinetic disposition and dosage regimen for carbenicillin in buffalo calves.
The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance of carbenicillin in healthy buffalo calves following a single intravenous administration (50 mg/kg) were 0.057 +/- 0.005 h, 1.688 +/- 0.11 h, 0.185 +/- 0.021 L kg-1 and 75.97 +/- 6.519 ml kg-1 h-1 respectively. A satisfactory dosage regimen for carbenicillin in buffalo calves was calculated to be 56 mg/kg followed by 52 mg/kg body weight repeated at 6 h intervals.
Bal
M S
MS
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
Brar
K S
KS
D000818:Animals; D002020:Buffaloes / Q000378:metabolism*; D002228:Carbenicillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D008433:Mathematics; D012016:Reference Values; D014018:Tissue Distribution
D002228:Carbenicillin