Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein.
Various studies have shown that oligosaccharides play an important role in the intracellular transport and secretion of glycoproteins. We show here a difference in the rate of secretion of two mature glycoforms of a single protein, alpha 1-acid glycoprotein. This indicates the existence of kinetically different pathways for these two forms for transport from the medial Golgi to the extracellular medium.
Drechou
A
A
Laboratoire de Biochimie-URA CNRS 622, UFR des Sciences Pharmaceutiques et Biologiques, Châtenay-Malabry, France.
Rouzeau
J D
JD
Feger
J
J
Durand
G
G
D000418:Albumins / Q000378:metabolism; D000818:Animals; D006031:Glycosylation; D007249:Inflammation / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats; D011919:Rats, Inbred Strains; D011952:Receptors, Concanavalin A / Q000032:analysis; D013329:Structure-Activity Relationship
D000418:Albumins; D009961:Orosomucoid; D011952:Receptors, Concanavalin A