title: Second-look laparotomy in the patient with minimal residual stage III ovarian cancer (a Gynecologic Oncology Group Study).
abstract: One hundred eighty-six patients with minimal residual Stage III ovarian cancer (tumor mass less than or equal to 3 cm) were treated in a prospective randomized protocol (melphalan with or without Corynebacterium parvum). As per protocol 84 patients were eligible and underwent a second-look laparotomy with 41 (49%) having negative findings for persistent malignancy. Factors which affected survival after second look were presence or absence of macroscopic disease, age, and grade. Depending upon these prognostic factors, survival at 4 years after second look ranged from 31 to 100%. The role of second-look laparotomy is examined relative to these results.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston.
authors.forename: W T
authors.initials: WT
authors.lastname: Creasman
authors.forename: S
authors.initials: S
authors.lastname: Gall
authors.forename: B N
authors.initials: BN
authors.lastname: Bundy
authors.forename: J
authors.initials: J
authors.lastname: Beecham
authors.forename: R
authors.initials: R
authors.lastname: Mortel
authors.forename: H D
authors.initials: HD
authors.lastname: Homesley
mesh_terms: D005260:Female; D006801:Humans; D007813:Laparotomy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D012086:Reoperation