title: Clinical value of the measurement of bone remodelling markers in primary hyperparathyroidism.
abstract: This study was performed in order to evaluate the clinical usefulness of the measurement of total serum alkaline phosphatase activity (AP), serum osteocalcin (BGP) and urinary hydroxyproline (OHPr) in assessing bone remodelling in primary hyperparathyroidism. Thirty-two patients with primary hyperparathyroidism were included in the study. No statistically significant differences were observed between the mean values of Z-scores obtained for each marker. Furthermore, an inverse correlation was found between percentage of bone mineral content at the distal radius and both BGP (r = -0.57; p less than 0.05) and AP (r = -0.49; p less than 0.05). The results obtained demonstrate that, contrary to other metabolic bone diseases (e.g. Paget's disease of bone), all three markers examined may be used in clinical practice to evaluate the entity of skeletal turnover in primary hyperparathyroidism.
authors.affiliation: IV Patologia Speciale Medica e Metodologia Clinica, University of Rome La Sapienza, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Minisola
authors.forename: L
authors.initials: L
authors.lastname: Scarnecchia
authors.forename: V
authors.initials: V
authors.lastname: Carnevale
authors.forename: F
authors.initials: F
authors.lastname: Bigi
authors.forename: E
authors.initials: E
authors.lastname: Romagnoli
authors.forename: M T
authors.initials: MT
authors.lastname: Pacitti
authors.forename: R
authors.initials: R
authors.lastname: Rosso
authors.forename: G F
authors.initials: GF
authors.lastname: Mazzuoli
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D006961:Hyperparathyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D006909:Hydroxyproline