beta-Adrenergic treatment of hyperkalemic periodic paralysis.
In a patient with hyperkalemic periodic paralysis, metaproterenol prevented muscular weakness and hyperkalemia in periods of rest after exercise. During a severe attack, the drug rapidly corrected hyperkalemia and seemed to enhance the return of strength. The action of metaproterenol may involve a beta-adrenergic-mediated increase of potassium transport via the sodium-potassium pump.
Bendheim
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PE
Reale
E O
EO
Berg
B O
BO
D000293:Adolescent; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D009921:Metaproterenol / Q000627:therapeutic use*; D009119:Muscle Contraction; D010245:Paralyses, Familial Periodic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005082:Physical Exertion; D011188:Potassium / Q000378:metabolism; D012146:Rest
D007473:Ion Channels; D009921:Metaproterenol; D011188:Potassium