title: [Comparison of quantitative liver function tests to clinical, laboratory chemical and biopsy findings in patients with liver diseases].
abstract: Quantitative liver function tests (QLFT), e.g. 1) galactose elimination capacity (GEK) and 2) fractional indocyanine-green elimination constant k (ICG) were performed in patients with various liver diseases. Retrospectively the results of QLFT were compared to clinical, histological and laboratory findings which are known to reflect severity of liver disease. Patients showing clinical symptoms like ascites and/or encephalopathy demonstrated lower values for GEK and ICG. In addition similar data were obtained for those patients who showed histological evidence of cirrhosis. When dividing up the group of cirrhotics according to PUGH's classification, correspondingly lower results of QLFT were observed between different PUGH classes, however, due to a substantial overlap an individual classification could not be achieved by QLFT. Compared to routine laboratory tests which might estimate hepatic functional impairment the following correlations were found: GEK to albumin: r = 0.47, p < 0.01, to Quick: r = 0.44, p < 0.001, to bilirubin: r = -0.23, p < 0.05, ICG to albumin: r = 0.45, p < 0.01, to Quick: r = 0.53, p < 0.001, to bilirubin: r = -0.42, p < 0.001. No correlation could be demonstrated to transaminase activity. The results obtained support the view that QLFT are capable of estimating hepatic function, however, compared to conventional characteristics of advanced liver disease only moderate correlations were detected. A superiority of quantitative liver function tests could not be detected.
authors.affiliation: Abteilung Gastroenterologie und Endokrinologie, Medizinische Universitätsklinik Göttingen.
authors.forename: I
authors.initials: I
authors.lastname: Albers
authors.forename: H
authors.initials: H
authors.lastname: Hartmann
authors.forename: W
authors.initials: W
authors.lastname: Creutzfeldt
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005690:Galactose / Q000493:pharmacokinetics; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged
chemical_list: D007208:Indocyanine Green; D005690:Galactose
vernacular_title: Vergleich quantitativer Leberfunktionsprüfungen zu klinischen, laborchemischen und bioptischen Befunden bei Patienten mit Lebererkrankungen.