Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood.
Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown to react with a population of human peripheral blood mononuclear cells. The population is similar to the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). The population also includes cells exhibiting the Leu 2 marker for suppressor/cytotoxic T cells. The results indicate a shared antigenicity between the nervous system and the immune system and may be relevant to the pathogenesis of demyelinating diseases.
Dobersen
M J
MJ
Gascon
P
P
Trost
S
S
Hammer
J A
JA
Goodman
S
S
Noronha
A B
AB
O'Shannessy
D J
DJ
Brady
R O
RO
Quarles
R H
RH
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D009000:Monocytes / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein
D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein