[Can the function of the extirpated amygdaloid complex be compensated for by the transplantation of embryonic nerve tissue?].
In 20 white rats bilateral coagulation of the amygdalar complex was produced; on the fifth day to one half of them transplantation was performed by introducing stereotaxically on the left side 0.2-0.5 mm3 of the brain embryonal tissue from the corresponding area of the amygdala of 20-days embryo; in control saline was administered. After two months the rats were sacrificed to determine the activity of antiradical defense by superoxide dismutase (SOD) and the level of lipids peroxide oxidation (LPO) in the cerebral cortex. The transplantation decreased LPO even more and increased SOD as compared to amygdalectomy, e. i. caused still greater deviations from the norm (in this meaning--paradoxal effect), what apparently corresponds to intensification of adaptative-compensatory processes caused by amygdalectomy. The transplantation did not reverse the rats behaviour to the initial one and did not eliminate memory defect in the test of conditioned reaction of passive avoidance (like pyrazetam); it had different direction influence on "drinking under current" in conflict situation, only in particular cases approaching it to the norm.
Khonicheva
N M
NM
Lushchekina
E A
EA
Kurbatyova
M B
MB
Guliaeva
N V
NV
Obidin
A B
AB
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003220:Conflict, Psychological; D004564:Electrocoagulation; D004622:Embryo, Mammalian; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism
D013482:Superoxide Dismutase; D010889:Piracetam
Mozhno li kompensirovat' funktsiiu udalennogo mindalevidnogo kompleksa mozga putem transplantatsii émbrional'noĭ nervnoĭ tkani?