Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months.
To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunisation. For the 55% of children who were seronegative before vaccination at age 4-5 months seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. Seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccination with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months was as good as vaccination with the AIK-C strain at 8-10 months and better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that the administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months.
Tidjani
O
O
CHU, Lomé, Togo.
Grunitsky
B
B
Guérin
N
N
Lévy-Bruhl
D
D
Lecam
N
N
Xuereff
C
C
Tatagan
K
K
D000914:Antibodies, Viral / Q000032:analysis*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*
D000914:Antibodies, Viral; D008458:Measles Vaccine