[The specific binding of dihydroalprenolol and quinuclidinyl benzilate with myocardial lysosomes].
The binding of 3H-dihydroalprenolol and 3H-quinuclidinyl benzylate to lysosomes of the rat ventricular myocardium vas studied. More than one type of specific binding sites of dihydroalprenolol and quinuclidinyl benzylate at the rat myocardium lysosomes were found. The association constants values differ from the known values of the association constants of the same ligands with plasmatic membranes of the mammalian myocardium.
Sysoliatina
N A
NA
Tomilenko
V I
VI
D000526:Alprenolol / Q000031:analogs & derivatives*; D000818:Animals; D004082:Dihydroalprenolol / Q000493:pharmacokinetics*; D006352:Heart Ventricles / Q000201:enzymology; D008024:Ligands; D008247:Lysosomes / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D011812:Quinuclidines / Q000493:pharmacokinetics*; D011813:Quinuclidinyl Benzilate / Q000493:pharmacokinetics*; D051381:Rats
D008024:Ligands; D011812:Quinuclidines; D004082:Dihydroalprenolol; D011813:Quinuclidinyl Benzilate; D000526:Alprenolol
Spetsificheskoe sviazyvanie digidroalprenolola i khinuklidinila benzilata s lizosomami miokarda.