[Influence of zinc deprivation on thymus, spleen development and adenosine deaminase activity in young rats].
This study on the thymus and spleen development and ADA activity was done in young rats with zinc deprivation and supplementation. The serum zinc level, body weight, absolute and relative weight, and ADA activity of the thymus and spleen were compared between the experimental rats and the control group. Above indications were all decreased; especially both the thymus weight and the thymus ADA activity were markedly decreased in the zinc deficient group. The averages of thymic absolute weight, relative weight and ADA activity were dropped by 61.32%, 54.54% and 47.59%, respectively. After zinc supplementation for one month, all the body weight, weight of the thymus and spleen, and ADA activity of the spleen were recovered to the control group's level, while ADA activity of the thymus was 33.03% higher than that of the control group. Our data suggested that zinc was not only an important trace element in maintaining the growth of the body, the development of the thymus and spleen, but it may be an important agent to activate the ADA or to prompt synthesis of ADA.
Luo
C H
CH
Chen
J
J
Yang
X J
XJ
Li
Y Q
YQ
Xu
B
B
Zheng
D Y
DY
Qian
Y Q
YQ
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D005260:Female; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000254:growth & development*; D013950:Thymus Gland / Q000254:growth & development*; D015032:Zinc / Q000172:deficiency* / Q000494:pharmacology
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D015032:Zinc