title: The role of MHC and non-MHC antigens in the rejection of intracerebral allogeneic neural grafts.
abstract: Embryonic DA retinal allografts that have survived for prolonged periods after having been transplanted into the brains of neonatal BN rats can be induced to reject following peripheral sensitization with a DA skin graft. The results show that histocompatibility antigens play the major role in the rejection of grafts placed in the CNS and that a disparity between the retinal and skin grafts for MHC antigens induces a more severe rejection response than does a non-MHC antigen disparity.
authors.affiliation: Department of Neurobiology, Anatomy, and Cell Science, University of Pittsburgh School of Medicine, Pennsylvania 15261.
authors.forename: K
authors.initials: K
authors.lastname: Rao
authors.forename: R D
authors.initials: RD
authors.lastname: Lund
authors.forename: H W
authors.initials: HW
authors.lastname: Kunz
authors.forename: T J
authors.initials: TJ
authors.lastname: Gill
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000276:immunology*; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000502:physiology*; D051381:Rats; D012160:Retina / Q000637:transplantation*; D016038:Skin Transplantation; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
chemical_list: D006649:Histocompatibility Antigens