title: Hypotensive effects of nifedipine in patients with primary hyperparathyroidism: case reports.
abstract: Nifedipine was administered orally to 2 patients with primary hyperparathyroidism before and after parathyroidectomy. The operation lowered serum calcium concentration and parathyroid hormone but did not alter plasma renin activity, plasma aldosterone concentration, and serum magnesium. The hypotensive effects of nifedipine were markedly enhanced with the decrease in serum calcium concentration following parathyroidectomy. Thus, the level of serum calcium concentration may modulate the hypotensive effect of nifedipine in humans.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takata
authors.forename: S
authors.initials: S
authors.lastname: Takishita
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: Y
authors.initials: Y
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: K
authors.initials: K
authors.lastname: Takemura
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010280:Parathyroid Glands / Q000601:surgery; D011674:Pulse / Q000187:drug effects
chemical_list: D009543:Nifedipine; D002118:Calcium