title: Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice.
abstract: In order to study the genotoxicity of arsenics, we focused our attention on dimethylarsinic acid (DMAA) which was a main metabolite of inorganic arsenics in mammals. ICR mice were orally administered DMAA-Na (1500mg/kg). DNA single-strand breaks occurred specifically in lung at 12h after administration. An in vitro experiment indicated that the breaks were not caused directly by DMAA but by dimethylarsine, a further metabolite of DMAA. Furthermore, the dimethylarsine-induced breaks were diminished by the addition of SOD and catalase, suggesting that active oxygen produced by dimethylarsine was involved in the induction of DNA damage.
authors.affiliation: Department of Pharmacy, Nihon University College of Science and Technology, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamanaka
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
authors.forename: R
authors.initials: R
authors.lastname: Sawamura
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D000818:Animals; D001149:Arsenates / Q000032:analysis; D001151:Arsenic / Q000633:toxicity*; D002374:Catalase / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009928:Organ Specificity; D012119:Respiration; D013482:Superoxide Dismutase / Q000494:pharmacology
chemical_list: D001149:Arsenates; D004277:DNA, Single-Stranded; D002374:Catalase; D013482:Superoxide Dismutase; D001151:Arsenic; C025657:arsenic acid