Inhibition of paraquat accumulation in rabbit kidney cortex slices by ascorbic acid.
Effects of ascorbic acid and Fe2+ on the accumulation of paraquat into rabbit kidney cortical slices were studied. Ascorbic acid showed dose-dependent inhibition of paraquat accumulation. Fe2+ had a more powerful stimulatory effect on the lipid peroxidation of cortical slices than ascorbic acid, but it did not reduce paraquat accumulation. These results suggest that ascorbic acid is able to inhibit the accumulation of paraquat independent of its peroxidative action, and that ascorbic acid may serve as an antidote for the toxicity of paraquat.
Fujimoto
Y
Y
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
Nakatani
E
E
Horinouchi
M
M
Okamoto
K
K
Sakuma
S
S
Fujita
T
T
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010269:Paraquat / Q000378:metabolism*; D011817:Rabbits; D013858:Thiobarbiturates / Q000494:pharmacology
D013858:Thiobarbiturates; D007501:Iron; D010269:Paraquat; D001205:Ascorbic Acid