title: Pharmacists' evaluations of the nonprescription availability of metaproterenol, cimetidine, ibuprofen, and nystatin.
abstract: The relative importance of six switch evaluation criteria in pharmacists' evaluations of the appropriateness of switching four drugs from prescription to nonprescription status was assessed. A questionnaire was constructed for three potential switch candidates (metaproterenol, cimetidine, and nystatin) and one already switched drug (ibuprofen 200 mg). Pharmacists were asked to judge (1) the overall appropriateness of switching these four drugs and (2) the appropriateness of switching these drugs based on the FDA switch criteria of safety, effectiveness, and labeling and two other proposed criteria: the need for oral counseling about the product and perceived market need for the product. Additionally, pharmacists were asked to rate whether they believed the study drugs would be profitable to their pharmacies if the drugs were switched to nonprescription status. A total of 1161 pharmacists were reached by the mailings, of whom 417 (34.8%) responded. Only ibuprofen 200 mg received a positive overall switch approval rating from the pharmacists; cimetidine received the lowest rating. The six evaluation criteria were tested for significant association with pharmacists' overall judgment of the appropriateness of switching each drug. The three most influential criteria were safety, labeling, and market need for the product, respectively. Profitability to the pharmacy was not significantly associated with pharmacists' overall judgment of switch appropriateness. Regression analysis identified safety, labeling, and market need as important in the evaluation of all four drugs, and pharmacists' evaluation of the relative importance of these criteria was a predictor of their overall judgment of the appropriateness of a switch. Consumer safety, not personal economic interests, most influenced pharmacists' judgment of the appropriateness of a switch from prescription to nonprescription status for four drugs.
authors.affiliation: Department of Behavioral and Administrative Pharmacy, School of Pharmacy, West Virginia University, Morgantown 26506.
authors.forename: S
authors.initials: S
authors.lastname: Madhavan
authors.forename: S W
authors.initials: SW
authors.lastname: Schondelmeyer
mesh_terms: D001291:Attitude of Health Personnel; D002927:Cimetidine / Q000627:therapeutic use*; D007052:Ibuprofen / Q000627:therapeutic use*; D009921:Metaproterenol / Q000627:therapeutic use*; D004366:Nonprescription Drugs; D009761:Nystatin / Q000627:therapeutic use*; D010595:Pharmacists; D012044:Regression Analysis; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D004366:Nonprescription Drugs; D009761:Nystatin; D009921:Metaproterenol; D002927:Cimetidine; D007052:Ibuprofen