title: Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins.
abstract: Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significantly greater reduction in these parameters was found after treatment with HAP compared to placebo, indicating an improvement in lower limb venous circulation.
authors.affiliation: Secteur d'Angiologie, Médecine H, Centre Hospitalier Régional et Universitaire de Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: R
authors.initials: R
authors.lastname: Gavoille
authors.forename: P
authors.initials: P
authors.lastname: Perez
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
mesh_terms: D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000605:Amino Alcohols / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006535:Heptaminol / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014648:Varicose Veins / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000605:Amino Alcohols; D006535:Heptaminol; D000249:Adenosine Monophosphate; C053918:heptaminol AMP amidate