title: Failure of amphotericin B spray to prevent aspergillosis in granulocytopenic patients.
abstract: We tested the efficiency of a nasal spray of Amphotericin B (AmB) in leukemic patients, in an attempt to prevent pulmonary Aspergillosis. From January to July, 8 cases of invasive Aspergillosis (IA) in 19 new leukemic patients were identified. Between July and September 15 patients were treated by prophylactic nasal spray of AmB (daily dose 5 mg). Compliance was excellent, but nevertheless typical IA developed in 5 patients. We conclude that at the dosage used prophylactic administration of nasal spray of (AmB) does not prevent IA.
authors.affiliation: Service d'Hématologie, Hôpital Cochin, Paris, France.
authors.forename: C J
authors.initials: CJ
authors.lastname: Jorgensen
authors.forename: F
authors.initials: F
authors.lastname: Dreyfus
authors.forename: J
authors.initials: J
authors.lastname: Vaixeler
authors.forename: S
authors.initials: S
authors.lastname: Guyomard
authors.forename: C
authors.initials: C
authors.lastname: Massiot
authors.forename: C
authors.initials: C
authors.lastname: Belanger
authors.forename: F
authors.initials: F
authors.lastname: Brunet
authors.forename: T
authors.initials: T
authors.lastname: Giraud
authors.forename: P
authors.initials: P
authors.lastname: Dupuis-Camay
mesh_terms: D000281:Administration, Intranasal; D000380:Agranulocytosis / Q000150:complications*; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007938:Leukemia / Q000150:complications; D008172:Lung Diseases, Fungal / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000666:Amphotericin B