[Extending the survival time of allogenic heart and kidney transplants in the rat by a combination of PUVA transplant conditioning and cyclosporin treatment of the recipient].
Dose-response studies of cyclosporin (CsA) established that a dose of 2 mg kg body weight on day 0 was of therapeutic suboptimal value in rat kidney allotransplantation. When PUVA-treated heart and kidney allografts were transplanted into temporary CsA immunosuppressed recipients the graft survival rates were further improved as compared with PUVA alone. Forty vs. 18% (heart) and 70 vs. 40% (kidney) of the PUVA + CsA vs. PUVA treated allografts survived permanently. Therefore a synergistic effect of PUVA pretreatment and low-dose CsA therapy on rat heart and renal allograft survival was demonstrated.
Oesterwitz
H
H
Klinik für Urologie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
Kaden
J
J
Schneider
W
W
Schirrow
R
R
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D016030:Kidney Transplantation; D008297:Male; D011701:PUVA Therapy; D011292:Premedication; D051381:Rats
D003524:Cyclosporins
Verlängerung der Uberlebenszeit allogener Herz- und Nierentransplantate bei der Ratte durch eine Kombination von PUVA-Transplantatkonditionierung und Cyclosporin-Empfängerbehandlung.