Nonlinear pharmacokinetics of intravenous sulphadimethoxine and its dosage regimen in pigs.
The time courses of the total (Ct) and unbound plasma (Cf) concentration after the i.v. injection of 20, 50 and 100 mg/kg of sulphadimethoxine (SDM) were examined in pigs. The area under the Ct-time curve per unit dose decreased dose-dependently. Vdarea and total body clearance of Ct increased dose-dependently. The concentration-dependent plasma protein binding of SDM was evident after 50 and 100 mg/kg. The time courses of Cf en Ct after 3 doses were analyzed by a one compartment open model with nonlinear plasma protein binding. The agreement between calculated curves of Cf and Ct and the observed values, and relative constancy of pharmacokinetic parameters were obtained over 3 doses. These results suggested that the nonlinear pharmacokinetics of SDM was caused by saturable plasma protein binding. The multiple i.v. dose of SDM was based on the dosage regimen using the nonlinear pharmacokinetic model (50 mg/kg, 24 hour interval, 4 days). The observed Cf was maintained in the intended range by the dosage regimen. Therefore, the dosage regimen based on the nonlinear pharmacokinetics may allow the unbound concentration after i.v. injection of SDM in pigs to be controlled.
Shimoda
M
M
Department of Veterinary Medicine, Tokyo University of Agricultural and Technology, Japan.
Kokue
E
E
Itani
M
M
Hayama
T
T
Vree
T B
TB
D000818:Animals; D004334:Drug Administration Schedule / Q000662:veterinary; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007700:Kinetics; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine
D013412:Sulfadimethoxine