Systemic lupus erythematosus and tetrasomy-X.
An 18-year-old woman with tetrasomy-X (48,XXXX karyotype) who developed systemic lupus erythematosus is described. This is, to our knowledge, the first recorded case of this association. The occurrence of autoimmune disorders in patients with chromosomal aberrations is discussed.
Alvaro-Gracia
J M
JM
Rheumatology Section, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
Humbria
A
A
García-Vicuña
R
R
Ariza
A
A
García-Vadillo
A
A
Laffón
A
A
D000293:Adolescent; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000235:genetics; D007621:Karyotyping; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics*; D014960:X Chromosome