title: Acute renal failure with glomerular thrombosis in a patient with chronic scleroderma.
abstract: A 48-year-old woman with a 20-year history of scleroderma presented with malignant hypertension, thrombocytopenia, and acute renal failure. Renal biopsy demonstrated vascular changes consistent with scleroderma and glomerular thrombi. Her clinical course was consistent with hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP)-like syndrome. Plasma exchange therapy was associated with an improvement in renal function and rise in platelet count. This case suggests that acute renal failure in patients with scleroderma can be associated with glomerular thrombi and may improve with plasma exchange therapy.
authors.affiliation: Department of Internal Medicine, Ohio State University, Columbus 43210.
authors.forename: D M
authors.initials: DM
authors.lastname: Ricker
authors.forename: H M
authors.initials: HM
authors.lastname: Sharma
authors.forename: N S
authors.initials: NS
authors.lastname: Nahman
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000628:therapy; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008875:Middle Aged; D010951:Plasma Exchange; D012595:Scleroderma, Systemic / Q000150:complications*; D013927:Thrombosis / Q000150:complications*