Acetylcholine receptor antibody in myasthenia gravis.
Radioimmunoassay techniques were used to detect antibodies to the acetylcholine receptor (AAChR) in 164 patients with adult-onset myasthenia gravis. AAChR levels above 0.6 nM/l were considered pathological and were found in 67% of the patients with an average value of 58.99 +/- 125.02 nM/l (0.6-900.0). Correlation, with clinical functional status, the histopathological thymus alterations and the different therapeutics used did not disclose any statistically significant differences.
Marchiori
P E
PE
Department of Neurology, São Paulo University Medical School, Brazil.
dos Reis
M
M
Quevedo
M E
ME
Scaff
M
M
Cossermelli
W
W
Assis
J L
JL
de Oliveira
R M
RM
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D013950:Thymus Gland / Q000473:pathology* / Q000601:surgery
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic