[Primary amyloidosis. Clinical manifestations].
Amyloidosis is distinguished by store both localized or systemic, of a substance conformed for 3 fraction: 1) protein (90%), 2) Mucopolysaccharides, 3) fatty and iron, with filament ultrastructure. These filaments are thin and rigid, with beta crystallographic shape. Four pattern of amyloid are distinguished. They are derived of light chains or another immunoglobulins, aminoacids or prealbumin like substance. If all deposits are protein filaments storage, one of their trials would be increased synthesis of them. This is not sufficient and need that these precursor proteins be attrached by macrophages they are subjected to proteolysis and are enclosed extracellularly. We present a female, 55 years old. The hepatic and renal participation permit to suspect an amyloidosis who is confirmed by the presence of monoclonal gammopathy and by biopsy of tissues.
Pisarevsky
J
J
Divisones de Gastroenterología y Clínica Médica Hospital Juan A. Fernández, Buenos Aires, Argentina.
Martínez
A
A
Zalar
A
A
Winkel
M
M
Piskorz
E
E
D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications; D011379:Prognosis
Amiloidosis primaria. Manifestaciones clínicas.