title: Motor and sensory blockade after epidural injection of mepivacaine, bupivacaine, and etidocaine--a double-blind study.
abstract: In a double-blind study of epidural anesthesia, 30 young volunteers were given either 2% mepivacaine (400 mg), 0.5% bupivacaine (100 mg), or 1.5% etidocaine (300 mg), all solutions containing epinephrine (1:200,000). The spread of analgesia was equal in the groups, whereas the longest duration was noted in the etidocaine and bupivacaine groups. With use of a method for determining muscle force, motor blockade during anesthesia was recorded quantitatively for hip flexion, knee extension, and plantar flexion of the big toe. Onset of motor blockade was significantly more rapid with etidocaine than with bupivacaine and mepivacaine. All subjects given etidocaine developed complete motor blockade, but with the other local anesthetics 5%-33% of the initial muscle force remained. The least motor blockade was found in the L5-S2 segment (plantar flexion of the big toe). The duration of maximal motor blockade varied between 60 min (mepivacaine) and 360 min (etidocaine). With each of the three local anesthetics, motor function returned simultaneously in the three muscle groups tested. Complete restoration of muscle function occurred significantly later for etidocaine (600 min) than for bupivacaine (360 min) and mepivacaine (180 min). With etidocaine, the motor blockade outlasted the sensory blockade by 150 min. The Bromage scale corresponded to the motor blockade only during the first half of the regression phase. Not until 1-3 h after attainment of Bromage grade 0 was the muscle force of all movements restored (90% of control values).
authors.affiliation: Department of Anesthesiology and Intensive Care, Orebro Medical Center Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Axelsson
authors.forename: P A
authors.initials: PA
authors.lastname: Nydahl
authors.forename: L
authors.initials: L
authors.lastname: Philipson
authors.forename: P
authors.initials: P
authors.lastname: Larsson
mesh_terms: D000083:Acetanilides / Q000008:administration & dosage*; D000328:Adult; D000767:Anesthesia, Epidural / Q000379:methods*; D002045:Bupivacaine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005041:Etidocaine / Q000008:administration & dosage*; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage*; D009068:Movement; D012677:Sensation; D013997:Time Factors
chemical_list: D000083:Acetanilides; D008619:Mepivacaine; D005041:Etidocaine; D002045:Bupivacaine