title: Thioethers, mutagens, and D-glucaric acid in urine of operating room personnel exposed to anesthetics.
abstract: Mutagenic hazards related to occupational exposure to nitrous oxide and enflurane was studied in the personnel of five operating rooms using a coupled environmental and biological monitoring approach. The environmental monitoring revealed air concentrations of the two anesthetics exceedings the TLVs by 10-15-fold. These values were correlated individually with the concentrations of the two anesthetics in the expired air of the exposed subjects. The biological monitoring was carried out by determining two parameters associated with mutagen exposure (urinary mutagenicity and thioethers) and a parameter associated with the enzymatic induction (D-glucaric acid) in the urine of exposed and unexposed subjects (N = 64 and N = 37, respectively). The results showed no difference in the two groups for urine mutagenicity and D-glucaric acid, but urine thioethers were significantly increased among highly exposed subjects.
authors.affiliation: Department of Hygiene, University of Perugia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pasquini
authors.forename: S
authors.initials: S
authors.lastname: Monarca
authors.forename: G
authors.initials: G
authors.lastname: Scassellati Sforzolini
authors.forename: F A
authors.initials: FA
authors.lastname: Bauleo
authors.forename: G
authors.initials: G
authors.lastname: Angeli
authors.forename: F
authors.initials: F
authors.lastname: Cerami
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D000776:Anesthesiology; D000777:Anesthetics / Q000032:analysis / Q000493:pharmacokinetics*; D004737:Enflurane / Q000493:pharmacokinetics; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D013502:General Surgery; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D008297:Male; D009153:Mutagens / Q000652:urine*; D009609:Nitrous Oxide / Q000493:pharmacokinetics; D009871:Operating Room Nursing; D009873:Operating Rooms; D010564:Personnel, Hospital; D013400:Sugar Acids / Q000652:urine*; D013440:Sulfides / Q000652:urine*
chemical_list: D000395:Air Pollutants, Occupational; D000777:Anesthetics; D009153:Mutagens; D013400:Sugar Acids; D013440:Sulfides; D004737:Enflurane; D009609:Nitrous Oxide; D005937:Glucaric Acid