[Functional state of blood platelets in arterial hypertension and the changes in serotonin-containing cellular granules].
The study was undertaken to examine the status of the granular apparatus and platelet aggregability in 9 healthy donors and 18 patients with arterial hypertension (AH), including 14 with essential hypertension (EH) and 4 with symptomatic forms of AH. Among the patients, a group of 8 EH patients was singled out, who had, compared with normal, reduced relative volumes of electron dense platelet granules (from 17.9 +/- 2.0 to 5.3 +/- 0.6%). The group also showed lower platelet serotonin levels (from 67.3 +/- 5.3 to 17.6 +/- 3.7 ng per 10(8) cells; p less than 0.001) and a 2-fold decrease in the transport factor of acridine orange across the cytoplasmic and granular membranes as compared to normal. A positive correlation was established between the amounts of cellular serotonin and the relative volume of platelet granules (r = 0.850; p less than 0.001).
Mezhlumian
A G
AG
Vikhert
O A
OA
Gabbasov
Z A
ZA
Maĭsov
N I
NI
Gavrilov
I Iu
IIu
KrotovSN
Arabidze
G G
GG
Popov
E G
EG
D000328:Adult; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D012701:Serotonin / Q000097:blood* / Q000172:deficiency
D012701:Serotonin
Funktsiona'lnoe sostoianie krovianykh plastinok pri arteria'lnoĭ gipertonii i izmeneniia serotoninsoderzhashchikh granul kletok.