title: Close linkage of hypervariable marker DXS255 to disease locus of Wiskott-Aldrich syndrome.
abstract: Linkage analyses in 5 families with Wiskott-Aldrich syndrome show that a novel hypervariable locus, DXS255, is very closely linked to the disease gene on the proximal short arm of the X chromosome. DXS255, with a maximum lod score of 5.42 at theta = 0.00 (90% confidence interval 0.00, 0.10) and heterozygosity of over 90%, is likely to be the closest available marker to the Wiskott-Aldrich gene and to be helpful in genetic counselling of affected families.
authors.affiliation: Unité 132 INSERM, Hôpital des Enfants Malades, Paris.
authors.forename: G
authors.initials: G
authors.lastname: de Saint Basile
authors.forename: B
authors.initials: B
authors.lastname: Arveiler
authors.forename: N J
authors.initials: NJ
authors.lastname: Fraser
authors.forename: Y
authors.initials: Y
authors.lastname: Boyd
authors.forename: I W
authors.initials: IW
authors.lastname: Graig
authors.forename: G
authors.initials: G
authors.lastname: Griscelli
authors.forename: A
authors.initials: A
authors.lastname: Fischer
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis*; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D008297:Male; D008540:Meiosis; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012307:Risk Factors; D014923:Wiskott-Aldrich Syndrome / Q000235:genetics*; D014960:X Chromosome
chemical_list: D005819:Genetic Markers