Difference in dose-response curves for glucose-induced insulin and somatostatin release in rat pancreas.
We studied the glucose dependence of insulin and somatostatin release from rat pancreata, which were perfused in vitro in the presence of 3-isobutyl-1-methylxanthine (IBMX; 0.5 mM). Half-maximal insulin release occurred at approx. 12 mM glucose, and half-maximal somatostatin release at approx. 7 mM glucose.
Dettori-Gera
C
C
Ronner
P
P
Scarpa
A
A
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin; D005947:Glucose; D015056:1-Methyl-3-isobutylxanthine