Liver gamma-glutamyl transpeptidase activity following chronic treatment with acetylsalicylic acid in rats.
In the present study, rats were administered acetylsalicylic acid (ASA), at low and high doses, by means of a gastric tube for 30 days. Chronic administration of a high dose of ASA (200 mg/kg body weight) resulted in a significant increase in liver plasma membrane gamma-glutamyl transpeptidase activity, cholesterol, and phospholipid levels. The enzymatic activity and lipid levels appeared not to be affected by ASA when given at a lower dose (50 mg/kg body weight). The changes in the enzymatic activity of plasma membrane were positively correlated to membrane cholesterol content. These findings suggest that the hepatotoxicity of high doses of ASA should not be overlooked during clinical use of the drug.
Omer
B
B
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
Eryürek
F
F
Oner
P
P
Baysal
K
K
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D001241:Aspirin