Effect of valproic acid on 5-hydroxytryptamine turnover in mouse brain.
The effect of the antiepileptic drug valproic acid (di-n-propylacetic acid, 200 mg kg-1) on brain 5-hydroxytryptamine (5-HT) synthesis during monoamine oxidase inhibition by pargyline hydrochloride (120 mg kg-1) was studied in mice. Valproic acid increased 5-HT synthesis and elevated 5-hydroxyindoleacetic acid level in brain indicating that turnover of 5-HT is increased. The possible significance of this effect in relation to anticonvulsant action of valproic acid is discussed.
Whitton
P S
PS
Oresković
D
D
Jernej
B
B
Bulat
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D010293:Pargyline / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*; D014635:Valproic Acid / Q000494:pharmacology*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014635:Valproic Acid; D010293:Pargyline