title: Inhibition of the late phase response to anti-IgE in humans by indomethacin.
abstract: The hypothesis of cyclooxygenase derivates of arachidonic acid as putative mediators of late phase skin reactions (LPR) was evaluated by studying the effect of indomethacin and naproxen on anti-IgE elicited skin reactions in healthy volunteers. Indomethacin 50 mg t.i.d., 48 h prior to and up to 24 h following challenge with anti-IgE 1/3300 (v/v), produced a slight attenuation of the flare response and a 35% inhibition of the LPR (P less than 0.05) at 1-24 h as compared with placebo (n = 11). Naproxen, 250 mg, b.i.d. showed analogous anti-LPR effect (n = 4, P less than 0.05). Intradermally (i.d.) injected indomethacin, 75 micrograms (7 X 10(-3) mol/l), attenuated the flare and LPR to anti-IgE 1/330 at 1-6 h (n = 12, P less than 0.01). Indomethacin, oral and i.d., enhanced the LPR to various dilutions of anti-IgE in 30% of the individuals. The results suggest that prostaglandins and thromboxanes participate in the development of an LPR in human skin.
authors.forename: R
authors.initials: R
authors.lastname: Grönneberg
authors.forename: O
authors.initials: O
authors.lastname: Zetterström
mesh_terms: D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001095:Arachidonic Acids / Q000276:immunology; D016861:Cyclooxygenase Inhibitors; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007213:Indomethacin / Q000494:pharmacology*; D007428:Intradermal Tests; D008875:Middle Aged; D009288:Naproxen / Q000494:pharmacology; D011453:Prostaglandins / Q000276:immunology; D011817:Rabbits
chemical_list: D000893:Anti-Inflammatory Agents; D000888:Antibodies, Anti-Idiotypic; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D007073:Immunoglobulin E; D009288:Naproxen; D007213:Indomethacin