Genetic and synteny mapping of parathyroid hormone and beta hemoglobin in cattle.
Parathyroid hormone and the beta hemoglobin gene cluster, which are closely linked on human chromosome 11p15, were localized to bovine syntenic group (U7) with the gene for catalase by the use of bovine x hamster hybrid somatic cells. Restriction fragment length polymorphisms (RFLPs) were followed through informative pedigrees to determine a linkage map distance of 15.6 +/- 5.4 cM between the parathyroid hormone and hemoglobin genes. Allelic frequencies of the DNA fragment were compared in a small sampling of cattle from five different breeds.
Foreman
M E
ME
Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Womack
J E
JE
D000818:Animals; D002374:Catalase / Q000235:genetics; D002417:Cattle; D002459:Cell Fusion; D002460:Cell Line; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005796:Genes; D006454:Hemoglobins / Q000235:genetics*; D007962:Leukocytes / Q000166:cytology; D010281:Parathyroid Hormone / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D006454:Hemoglobins; D010281:Parathyroid Hormone; D004247:DNA; D002374:Catalase