[Mechanisms of the antiaggregation activity of 1,4-naphthoquinone derivatives].
The antiaggregation effects of synthetic derivatives of 1,4-naphtoquinone and ionol were studied as compared with the antioxidant properties of the agents. The proportional relationship was shown to exist between the antiaggregation properties of the compounds and their antiradical activity under conditions of the interaction with biosubstrates. The data obtained suggest that the derivatives of 1,4-naphtoquinone with the intramolecular transfer of the charge are promising antiaggregation agents.
Levin
G S
GS
Kalmykova
I B
IB
Shneĭvaĭs
V B
VB
Kamenetskaia
Ts L
TsL
Dregeris
Ia Ia
IaIa
D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009285:Naphthoquinones / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D014812:Vitamin K / Q000031:analogs & derivatives / Q000494:pharmacology; D024483:Vitamin K 3
D000975:Antioxidants; D009285:Naphthoquinones; D010975:Platelet Aggregation Inhibitors; C053314:AK 135; D014812:Vitamin K; D002084:Butylated Hydroxytoluene; D024483:Vitamin K 3; C035342:1,4-naphthoquinone
K mekhanizmu antiagregatsionnoĭ aktivnosti proizvodnykh 1,4-naftokhinona.