[Ultrastructure of the peri-infarction zone during treatment of experimental myocardial infarct with cardiolin].
Cardiolin therapy influence on the periinfarction zone cardiomyocyte ultrastructure, sarcolemma permeability for colloidal lantan, myocardium energy level were studied in 25 white noninbred rats with experimental myocardial infarction. 6 hours after coronary occlusion ultrastructural damage in treated rats was less pronounced and mitochondria energy efficiency ratio was higher than those in the control group. 24 hours after the occlusion the tendency to normalization of the cardiomyocyte damage in treated rat myocardium was demonstrated, while in non-treated animals ischemic damage becomes irreversible, this being confirmed by the test with colloidal lantan. Cardiolin therapy prevents the infarction zone expansion by decreasing ischemic damage of periinfarction cardiomyocytes and by stimulating regeneration processes in these cells.
Khlystov
V V
VV
Pavlenko
V S
VS
Khavinson
V Kh
VKh
Morozov
V G
VG
Slepushkin
V D
VD
D000818:Animals; D003331:Coronary Vessels / Q000648:ultrastructure; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats
D010455:Peptides; C053892:cytomedins
Ul'trastruktura okoloinfarktnoĭ zony pri lechenii kardiolinom éksperimental'nogo infarkta miokarda.