Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant.
Hb Luxembourg [alpha 24(B5)Tyr----His] was found in association with mild hemolytic anemia and increased indirect bilirubinemia in a family originating from the Netherlands. The slight instability of this variant may be the consequence of an indirect effect of the substitution on the alpha 1 beta 1 contact since position alpha 24 (B5) is internal and in contact with several residues involved in this interface.
Groff
P
P
Division d'Hématologie, Laboratoire National de Santé, Luxembourg.
Galacteros
F
F
Kalmes
G
G
Blouquit
Y
Y
Wajcman
H
H
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005260:Female; D014644:Genetic Variation; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000302:isolation & purification; D006639:Histidine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000302:isolation & purification; D014357:Trypsin; D014443:Tyrosine
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; C062067:hemoglobin Luxembourg; D014443:Tyrosine; D006639:Histidine; D014357:Trypsin