The role of the sympathetic nervous system in cysteamine-induced gastric lesions in rats.
Cysteamine.HCl, when administered subcutaneously at 350 mg/kg, consistently induced severe gastric lesions in Wistar Kyoto rats (WKY), but not in spontaneously hypertensive rats (SHR). In both WKY and SHR, visible ulcers could not be induced in the duodenum in response to cysteamine. It appears that the stomach and duodenum of SHR are resistant to cysteamine due to hyperfunctioning of the sympathetic nervous system.
Shikuwa
S
S
Department of Pathology, Nagasaki University School of Medicine, Japan.
Naito
S
S
Chaotien
H
H
Shichijo
K
K
Kawase
Y
Y
Ito
M
M
Sekine
I
I
Imamura
K
K
D000818:Animals; D001794:Blood Pressure; D003543:Cysteamine; D004386:Duodenum / Q000187:drug effects; D005260:Female; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013272:Stomach Diseases / Q000139:chemically induced / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D003543:Cysteamine