Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses.
The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40 degrees C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.
Fiszon
B
B
Unité d'Ecologie Virale, Institut Pasteur, Paris.
Hannoun
C
C
Garcia-Sastre
A
A
Villar
E
E
Cabezas
J A
JA
D000818:Animals; D001831:Body Temperature; D002460:Cell Line; D004372:Ducks; D006386:Hemagglutination Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000201:enzymology / Q000254:growth & development / Q000502:physiology*; D009439:Neuraminidase / Q000032:analysis; D013552:Swine; D013696:Temperature; D010948:Viral Plaque Assay; D014779:Virus Replication
D009439:Neuraminidase