Neurotrophic effect of angiotensin II, vasopressin and oxytocin on the ventral spinal cord of rat embryo.
We studied trophic effects of angiotensin II, vasopressin and oxytocin on explanted ventral spinal cord cultures from 13-14-old day rat embryos. There was a significant neurite promoting effect in angiotensin II and vasopressin-treated cultures. Angiotensin II had the most potent effect at any concentrations. It became clear that minimum effective concentration was 10(-8) M in angiotensin II and vasopressin respectively. Effect of these two neuropeptides was concentration-dependent. However, oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II and vasopressin have a neurotrophic effect on ventral spinal cord in cultures, and may contribute to therapeutic strategy of amyotrophic lateral sclerosis.
Ikeda
K
K
Fourth Department of Internal Medicine, Toho, Japan.
Kinoshita
M
M
Iwasaki
Y
Y
Shiojima
T
T
Takamiya
K
K
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D004622:Embryo, Mammalian; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin