title: [The RFLPs of St14/Taq I in Chinese and its application to gene analysis and prenatal diagnosis of hemophilia A].
abstract: The genomic DNA fragment St14 (DXS52) is located in q28 region of X chromosome that also contains the hemophilia A locus. The RFLPs of St14/Taq I in Chinese were studied. The frequency of allele 7A (3.6 kb) is 31%, which is obviously different from the data reported abroad. By use of the RFLPs, 8 families with hemophilia A were analysed, including 1 case for first trimester prenatal diagnosis at risk of hemophilia A.
authors.affiliation: Institute of Basic Medical Science, Chinese Academy of Medical Science, Beiging.
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: G Y
authors.initials: GY
authors.lastname: Wu
authors.forename: S W
authors.initials: SW
authors.lastname: Wang
authors.forename: Q S
authors.initials: QS
authors.lastname: Gao
authors.forename: X H
authors.initials: XH
authors.lastname: Jiang
authors.forename: J Z
authors.initials: JZ
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: N H
authors.initials: NH
authors.lastname: Sun
authors.forename: F Y
authors.initials: FY
authors.lastname: Wang
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Wu
mesh_terms: D044466:Asian People; D002681:China; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014960:X Chromosome