Inhibitory effect of ceruletide on haloperidol-induced catalepsy in rats.
Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg) significantly inhibited HPD (2 mg/kg)-induced increase in dopamine (DA) release from the rat striatum. This effect of CLT was also antagonized by proglumide. These results suggest that CLT (160 micrograms/kg) primarily acts on cholecystokinin-A receptor in the brain, exerts some modulatory influence on HPD binding to striatal DA receptors via unknown neural pathways and, consequently, inhibits HPD catalepsy.
Ibii
N
N
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Ikeda
M
M
Takahara
Y
Y
Eigyo
M
M
Akiyoshi
T
T
Matsushita
A
A
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced*; D002108:Ceruletide / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
D015102:3,4-Dihydroxyphenylacetic Acid; D002108:Ceruletide; D006220:Haloperidol; D004298:Dopamine