Stimulation of gastric and colonic mucosal eicosanoid synthesis by plantain banana.
Extracts of plantain banana (Musa sapientum Linn var. paradisiaca) were studied on the accumulation of eicosanoids in incubates of human gastric and colonic mucosa. The ethanolic extract caused a concentration-dependent increase in the eicosanoid accumulation but the water extract was ineffective. Since all the eicosanoids studied tended to increase, banana may act by increasing the availability of arachidonate. In control tissues the accumulation of PGE and TXB2 in the incubates decreased with time while that of 6-keto-PGF1 alpha increased (colon only, studied).
Goel
R K
RK
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, UK.
Tavares
I A
IA
Bennett
A
A
D015777:Eicosanoids / Q000096:biosynthesis*; D000431:Ethanol; D005638:Fruit; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D011863:Radioimmunoassay; D013268:Stimulation, Chemical
D015777:Eicosanoids; D010936:Plant Extracts; D000431:Ethanol; D007213:Indomethacin