[The (15N) ammonium test in clinical research].
By use of the [15N]-ammoniumtest the liver function is investigated under influence of hormonal contraceptives in women and in liver diseases in children. With the described noninvasive nonradioactive isotope test the ammonia detoxification capability and the urea synthesis capacity of the liver is determined by measuring of the 15N-exceretion in ammonia and urea in the urine after oral administering of [15N]-ammonium chloride. The [15N]-ammonium test shows a significant influence of the hormonal contraceptives on the liver function and gives diagnostic evidence for liver diseases in children.
Jung
K
K
Zentralinstitut für Isotopen- und Strahlenforschung Leipzig, Akademie der Wissenschaften der DDR.
Metzner
C
C
Teichmann
B
B
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000643:Ammonium Chloride; D001806:Blood Urea Nitrogen; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis*; D009587:Nitrogen Isotopes; D005723:gamma-Glutamyltransferase / Q000097:blood
D003278:Contraceptives, Oral, Hormonal; D009587:Nitrogen Isotopes; D000643:Ammonium Chloride; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase
Der [15N]-Ammoniumtest in der klinischen Forschung.