Use of cyclosporin in psoriasis.
In the treatment of severe psoriasis, cyclosporin may achieve improvement or remission at low doses, but relapse usually occurs on withdrawal of treatment. An initial dose of 3 mg/kg per day is recommended. Complete remission should not be the objective, and the role of long-term maintenance cyclosporin therapy is uncertain because of potential side-effects--especially nephrotoxicity, hypertension, and a predisposition to malignancy. Guidelines are proposed for the assessment of such treatment.
Bos
J D
JD
Department of Dermatology, University of Amsterdam, The Netherlands.
Meinardi
M M
MM
van Joost
T
T
Heule
F
F
Powles
A V
AV
Fry
L
L
D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005069:Evaluation Studies as Topic; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D012008:Recurrence; D013997:Time Factors
D003524:Cyclosporins