Multipoint linkage mapping of the Xq25-q26 region in a family affected by the X-linked lymphoproliferative syndrome.
We have performed, in a large Swiss family, a study of linkage between various DNA markers in the Xq24-27 region and the locus for the X-linked lymphoproliferative syndrome (XLP). Our results indicated that the marker DXS37 in Xq25-q26 is genetically linked to the XLP syndrome. The multipoint linkage analysis showed that the disease locus is distal to DXS11, but proximal to the hypoxanthine phosphoribosyl-transferase gene (HPRT).
Sylla
B S
BS
International Agency for Research on Cancer, Lyon, France.
Wang
Q
Q
Hayoz
D
D
Lathrop
G M
GM
Lenoir
G M
GM
D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008232:Lymphoproliferative Disorders / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D014960:X Chromosome
D005819:Genetic Markers