[Effects of large and small doses of vitamin E on the excitability of frog myocytes].
The effect of the fat-soluble vitamin E on electrophysiological characteristics was investigated on frog cardiomyocytes. Large and small doses of vitamin E produced qualitatively identical effects: shortening of the plateau and decrease of the AP--duration. We assume that large doses of vitamin E can affect the cardiomyocytes membrane transport function, mainly due to the activation of slow membrane channels.
Satybaldina
N K
NK
Frolov
V A
VA
D000200:Action Potentials; D000818:Animals; D002463:Cell Membrane Permeability; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009206:Myocardium / Q000166:cytology; D011896:Rana temporaria; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D014810:Vitamin E
Vliianie bol'shikh i malykh doz vitamina E na vozbudimost' miotsitov liagushki.