Synthesis and biological activity of a new squaric acid-formylmethionine peptide conjugate.
A new squaric acid-formylmethionine peptide has been synthesized. In view of its biological properties to induce lysosome release and to inhibit glyoxalase, this compound may be of pharmacologic value.
Kraus
J L
JL
Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille.
Castaing
M
M
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008190:Lyases / Q000037:antagonists & inhibitors*; D008247:Lysosomes / Q000378:metabolism*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000138:chemical synthesis / Q000494:pharmacology / Q000031:analogs & derivatives; D013056:Spectrophotometry, Ultraviolet
D003503:Cyclobutanes; C061883:squaric acid N-formylmethionyl-leucyl-phenylalanine methyl ester peptide conjugate; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008190:Lyases; D007791:Lactoylglutathione Lyase