title: [Control of the effectiveness of nitrate therapy with long-term ECG based on spontaneous ST segment changes].
abstract: In a population of 40 patients with coronary artery disease the overall incidence of spontaneous ischemic episodes during 24-h Holter monitoring could be significantly reduced with ISDN 120 mg ret. and ISDN 120 mg plus Diltiazem 120 mg ret. However, the intraindividual day-to-day variability of ischemic episodes on three consecutive days of Holter monitoring is taken into consideration, an intraindividual reduction of ischemic episodes of at least 97% is required to separate a true therapeutic effect from the considerable spontaneous variability.
authors.affiliation: Medizinische Klinik III der Universität zu Köln.
authors.forename: A
authors.initials: A
authors.lastname: Osterspey
authors.forename: H H
authors.initials: HH
authors.lastname: Osterhues
authors.forename: H
authors.initials: H
authors.lastname: Günther
authors.forename: H H
authors.initials: HH
authors.lastname: Hilger
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004110:Diltiazem / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008875:Middle Aged
chemical_list: D004110:Diltiazem; D007548:Isosorbide Dinitrate
vernacular_title: Effektivitätskontrolle einer Nitrattherapie mit dem Langzeit-EKG anhand spontaner ST-Streckenveränderungen.