Effect of antidepressant drugs and different receptor antagonists on the grooming induced by the dopamine D-1 agonist SKF 38393.
The effect of four antidepressant drugs: imipramine (IMI), amitriptyline (AMI), citalopram (CIT) and mianserin (MIA), as well as various receptor antagonists: prazosin (alpha 1), yohimbine (alpha 2), ritanserin (5-HT2), atropine (Ach), chlorpyramine (H1) and SCH 23,390 (D-1) on grooming potentiated by the selective D-1 receptor agonist SKF 38,393, as well as on spontaneous grooming was studied. Antidepressant drugs inhibited in a dose-dependent manner the SKF-38,393-induced grooming, as well as spontaneous grooming in rats and mice. A similar, dose-dependent inhibitory effect was shown by all the compounds mentioned above, which block various receptors. The results indicate that the inhibitory effect of antidepressants on the SKF 38,393-induced grooming is not specific.
Skuza
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Rogóz
Z
Z
Zak
J
J
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006120:Grooming / Q000187:drug effects*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000187:drug effects*; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D001552:Benzazepines; D015259:Dopamine Agents; D006634:Histamine H1 Antagonists; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D012702:Serotonin Antagonists; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine