[Organic changes in rabbits and rats in thiometon poisoning. II. Relation between ECG curve changes in rabbits and rats and cholinesterase inhibition and lysosomal hydrolase activation in acute thiometon poisoning].
ECG records were analysed in rabbits and rats administered with Intration. Similarly, analysed were ECG records in the animals which, apart from the insecticide, received PAM and Toxobidin. On administration of the pesticide, cardiasthenia and lowered tension of R and R waves, prolonged duration of PQ segments and QT intervals were found. In addition, some animals exhibited the first-degree a-v block and second-degree block in the form of Wencke-bach's period. On administration of PAM and Toxobidin ECG curve elements were largely normalized. This implies that some of the ECG impairments are reversible, which may be accounted for by inhibition and reactivation of AChE and AhE. On the other hand, ECG records did not demonstrate myocardial necrosis in pesticide-poisoned patients.
Giermaziak
H
H
D000208:Acute Disease; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004562:Electrocardiography; D004789:Enzyme Activation / Q000187:drug effects; D006867:Hydrolases / Q000378:metabolism*; D007306:Insecticides; D008247:Lysosomes / Q000201:enzymology*; D062025:Organophosphate Poisoning; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011817:Rabbits; D051381:Rats
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D006867:Hydrolases; C100178:thiometon
Zmiany narzadowe u królików i szczurów w przebiegu zatrucia zwiazkiem fosforotioalifatycznym. Cześć II. Współzalezność zmian krzywej elektrokardiograficznej u królików i szczurów od stopnia inhibicji esteraz cholinowych i aktywacji hydrolaz lizosomalnych w prezebiegu ostrego zatrucia insektycydem fosforotioalifatycznym.