title: Synthesis and antimicrobial activity of new substituted 10-methyl-1,2-dihydro-1-oxo-1,2,4-triazino(4,5-a)indoles.
abstract: Ten new 4,8-disubstituted 10-methyl-1,2-dihydro-1-oxo-1,2,4-triazino(4,5-a)indoles (5 and 6) were prepared by refluxing various 5-substituted indole-2-carbohydrazides (4) with triethylorthoformate or triethylorthoacetate in dimethylformamide. These derivatives were evaluated for their antimicrobial activity. Some of the title compounds possess fairly potent antimicrobial activity.
authors.affiliation: Department of Chemistry, Kamatak University, Dhawad, India.
authors.forename: S B
authors.initials: SB
authors.lastname: Rajur
authors.forename: A Y
authors.initials: AY
authors.lastname: Merwade
authors.forename: L D
authors.initials: LD
authors.lastname: Basanagoudar
authors.forename: P V
authors.initials: PV
authors.lastname: Kulkarni
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; D014227:Triazines