Biodistribution of anionic separated MDP complexes from different MDP preparations.
The biodistributions of different Tc-MDP complexes, separated from different MDP preparations by anionic exchange chromatography, were investigated. We included MDP preparations from one producer with both ascorbic and gentisic acid as stabilizing agent and one preparation with ascorbic acid from a second producer. Bone to soft tissue ratios in rats were compared for the different Tc-MDP complexes separated. It seems that the elution profile of the radiochromatogram may indicate the biodistribution of the preparation. Ascorbic acid and gentisic acid caused different elution profiles and the different complexes isolated were demonstrated to have different bone to muscle ratios.
Handeland
A
A
Department of Nuclear Medicine, Norwegian Radiumhospital, Montebello.
Lindegaard
M W
MW
Heggli
D E
DE
D000818:Animals; D001205:Ascorbic Acid; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002852:Chromatography, Ion Exchange; D005079:Excipients; D005841:Gentisates; D062385:Hydroxybenzoates; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013669:Technetium Tc 99m Medronate / Q000302:isolation & purification / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D005079:Excipients; D005841:Gentisates; D062385:Hydroxybenzoates; D001205:Ascorbic Acid; C010925:2,5-dihydroxybenzoic acid; D013669:Technetium Tc 99m Medronate