Scleroglucan sustained-release oral preparations. Part I. In vitro experiments.
Experiments performed in vitro with tablets and capsules indicate that the fungal polysaccharide scleroglucan is suitable for the formulation of sustained-release, oral dosage forms. Delivery of model drugs from the non-disintegrating matrix was studied in solutions buffered at different pH values. The effect on drug release of drug concentration, the physico-chemical properties of the drug, and the compression force used in the preparation of the matrix are reported, and the possible mechanisms of release are discussed.
Touitou
E
E
Hebrew University of Jerusalem, Israel.
Alhaique
F
F
Riccieri
F M
FM
Riccioni
G
G
Santucci
E
E
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005936:Glucans / Q000737:chemistry*; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics
D002214:Capsules; D003692:Delayed-Action Preparations; D005936:Glucans; D013607:Tablets; C045938:scleroglucan; D013806:Theophylline