[The role of free oxygen radicals in the pathogenesis of Fanconi's anemia].
The authors describe the results of a study into antioxidants (superoxide dismutase and catalase) and production of the active forms of oxygen (superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen) by blood and bone marrow leukocytes from patients with Fanconi's anemia. The generation of the active forms of oxygen was induced by silica particles while the formation of radical products was recorded by means of luminol-dependent chemiluminescence. Unbalanced excessive production of oxygen radicals such as hydroxyl radicals combined with a decrease in the activity of antioxidant defence enzymes was discovered. It is believed that it is this circumstance that causes the derangement of the membranous structures and multiple breakdowns in the hereditary apparatus. It is suggested that antiradical preparations may be applied to correcting therapy of patients with Fanconi's anemia.
Rumiantsev
A G
AG
Samochatova
E V
EV
Afanas'ev
I B
IB
Korkina
L G
LG
Suslova
T B
TB
D000293:Adolescent; D000741:Anemia, Aplastic / Q000209:etiology*; D000975:Antioxidants / Q000627:therapeutic use; D002374:Catalase / Q000097:blood; D002648:Child; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000201:enzymology; D005199:Fanconi Anemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D005260:Female; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D010100:Oxygen / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen
Rol' svobodnykh radikalov kisloroda v patogeneze anemii Fankoni.