The alpha 2-adrenoceptor antagonists idazoxan and yohimbine can unmask the postsynaptic dopamine agonist effects of B-HT 920.
Administration of B-HT 920 alone produced weak stereotypy in a small percentage (4-8%) of rats. In contrast, after combined administration of idazoxane and B-HT 920, stereotyped behaviors (sniffing and licking) were consistently produced in all rats. The appearance of stereotypy after combined treatment with yohimbine and B-HT 920 was inversely related to the dose of yohimbine. These data suggest that the alpha 2-adrenoceptor agonist effects of B-HT 920 can mask it's postsynaptic dopamine agonist effects.
Meltzer
L T
LT
Department of Pharmacology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105.
Wiley
J N
JN
Heffner
T G
TG
D000818:Animals; D001381:Azepines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D015259:Dopamine Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D019329:Idazoxan; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology*
D001381:Azepines; D004146:Dioxanes; D004147:Dioxins; D015259:Dopamine Agents; D015016:Yohimbine; C024763:talipexole; D019329:Idazoxan