[The effect of donor conditioning with cyclosporin on the survival time of allogenic heart transplants in the rat].
The aim of the study was to investigate the influence of a pretreatment of the heart donor with cyclosporin (CsA) at 25 or 50 mg kg BW on day -1 on survival time of rat heart allografts in a donor-recipient combination that was different at their major histocompatibility complex (MHC). No further immunosuppression was used. The survival of CsA-pretreated heart transplants was significantly prolonged in allogeneic recipients compared with untreated controls and 3 out of 10 grafts (25 mg kg) and 4 out of 9 grafts (50 mg kg) survived permanently. These preliminary experimental findings are new, but further investigations are necessary to increase the efficacy of this pretreatment protocol.
Oesterwitz
H
H
Klinik für Urologie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
Gruner
S
S
Schneider
W
W
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000276:immunology*; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D014019:Tissue Donors
D003524:Cyclosporins
Einfluss einer Spenderkonditionierung mit Cyclosporin auf die Uberlebenszeit allogener Herztransplantate bei Ratten.