[Do passive smokers have an increased risk of thrombosis?].
In contrast to the proven association between active smoking and vascular injury, as well as hemostatic imbalance, such a relation is not jet proven for passive smoking. Vascular damage induced by smoking, however, can be seen in the materno-fetal circulation of smoking mothers, being much more pronounced in the umbilical system than in fetal vessels. These lesions show fast recovery after birth. In non-smokers acute exposure to passive smoke induces a short-lasting activation of platelet function and the prostaglandin system, followed by a quick recovery. Chronic exposure of non-smokers to passive smoke, however, results in changes of these parameters comparable to those seen in smokers, characterized by an activation of platelet function and a decrease in platelet sensitivity to the antiaggregatory prostaglandin I2. These results suggest that in non-smokers with atherogenic risk factors passive smoking may contribute to the incidence of atherosclerosis, as well as acute complications (thrombosis).
Sinzinger
H
H
Atheroskleroseforschungsgruppe (ASF) Wien.
Virgolini
I
I
D000328:Adult; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000097:blood; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D014028:Tobacco Smoke Pollution
Besitzen Passivraucher ein erhöhtes Thromboserisiko?