title: Serum F protein: a new sensitive and specific test of hepatocellular damage.
abstract: F protein is a 44-kDa protein which is found mostly in the liver and circulates at much lower concentrations in the serum. Serum F protein has been measured, using a recently developed radioimmunoassay, in a variety of diseases and was appreciably raised only in patients with hepatocellular damage. The serum F protein concentration was a more sensitive and specific marker of liver damage than conventional liver function tests and showed a close correlation with the histological assessment of liver damage (r = 0.86, P less than 0.001). This new marker may be of value in the diagnosis and treatment of liver disease.
authors.affiliation: St. Charles' Hospital, London, UK.
authors.forename: G R
authors.initials: GR
authors.lastname: Foster
authors.forename: R D
authors.initials: RD
authors.lastname: Goldin
authors.forename: D B
authors.initials: DB
authors.lastname: Oliveira
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D006801:Humans; D007519:Isoantigens / Q000097:blood*; D008107:Liver Diseases / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D007519:Isoantigens; C030497:liver specific F antigen; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase