title: The role of surgery in the combined treatment of locally advanced breast cancer.
abstract: Sixty patients with stage IIIA and IIIB breast cancer have been treated with a combined modality approach including induction chemotherapy, surgery and adjuvant chemotherapy: 74.5% of patients achieved an objective response after 3 cycles of induction chemotherapy, and 98.3% of patients were rendered disease-free after induction chemotherapy and surgery or radiotherapy; at 4 years, actuarial survival and disease-free survival are 71.5% and 43%, respectively. These results are significantly better than our historical control, and locally advanced breast cancer must now be considered a curable disease when treated with an aggressive multimodal approach.
authors.affiliation: Divisioni di Oncologia Chirurgica e, Instituto Nazionale par la Ricerca sul Cancro, Genova, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Canavese
authors.forename: A
authors.initials: A
authors.lastname: Catturich
authors.forename: G
authors.initials: G
authors.lastname: Battistini
authors.forename: C
authors.initials: C
authors.lastname: Caroti
authors.forename: P
authors.initials: P
authors.lastname: Pronzato
authors.forename: G
authors.initials: G
authors.lastname: Gardin
authors.forename: D
authors.initials: D
authors.lastname: Amoroso
authors.forename: G
authors.initials: G
authors.lastname: Bertelli
authors.forename: P F
authors.initials: PF
authors.lastname: Conte
authors.forename: S
authors.initials: S
authors.lastname: Tomao
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015409:Mastectomy, Radical; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D004054:Diethylstilbestrol; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate