title: [Anti-necrosogenic action of natural and synthetic antioxidants in coronary occlusive myocardial infarct].
abstract: The synthetic liposoluble antioxidant BAT. 120 mg/kg, was found to produce markedly protective effects in a rat model of coronary occlusive myocardial infarction, whereas the water soluble BAT analogue, 4-Oxy-3,5-ditretbutylphenyl phosphonic acid sodiate (SFN-6), 100 mg/kg, displayed no protective effects. The natural antioxidant beta-carotene capable of displaying antioxidative activity at low partial O2 pressures was shown to reduce the size of postinfarct scar by 34% when given in a dose of 20 mg/kg. The synthetic antioxidants, BAT and SFN-6 given in doses of 100 to 120 mg/kg each decreased antioxidant enzyme activities in the intact or infarct-related myocardium. beta-carotene was found to lack inhibitory effects on the myocardial antioxidant enzymes, thus enhancing its cardioprotective properties.
authors.forename: G G
authors.initials: GG
authors.lastname: Konovalova
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: L A
authors.initials: LA
authors.lastname: Vakulova
authors.forename: T S
authors.initials: TS
authors.lastname: Kukhareva
authors.forename: A M
authors.initials: AM
authors.lastname: Vikhert
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D019207:beta Carotene
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D002338:Carotenoids
vernacular_title: Antinekrozogennoe deĭstvie prirodnykh i sinteticheskikh antioksidantov pri koronarookkliuzionnom infarkte miokarda.