title: Serum fluoride in children anaesthetized with enflurane.
abstract: The serum inorganic fluoride concentration (SF) was measured in 40 children aged 22 days to 11 yrs (five infants) undergoing enflurane anaesthesia lasting 20-200 min, at an inspiratory concentration of 0.8 or 1.0%. Regardless of age, SF peaked at 2-8 mumol l-1 after 20-40 min of enflurane exposure, and at 4-10 mumol 1-1 and 6-10 mumol l-1 after 41-90 min and 91-200 min of exposure, respectively. The highest individual value was 12.5 mumol l-1. Another 23 children, aged 1-16 yrs, received 0.8% enflurane for 60 min. The increase in SF was 3-9 mumol l-1, with no clear dependence on age. Altogether, the increase in SF was comparable to that detected in adults after anaesthesia of equal duration.
authors.affiliation: Department of Anaesthesia, Otolaryngological Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Oikkonen
authors.forename: O
authors.initials: O
authors.lastname: Meretoja
mesh_terms: D000375:Aging / Q000378:metabolism; D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D004737:Enflurane / Q000378:metabolism*; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D004737:Enflurane; D005459:Fluorides