title: Fat distribution and gamma-glutamyl transferase in relation to serum lipids and blood pressure in 38-year old Dutch males.
abstract: In this study we describe the associations between indicators of fatness, fat distribution, and alcohol consumption (gamma-glutamyl transferase) with serum lipids and blood pressure in a random selected group (n = 69) of 38-year old men. Waist circumference, subscapular skinfold and body mass index all had similar positive associations with total cholesterol, triglycerides and diastolic blood pressure. Gamma-glutamyl transferase levels were associated with indicators of fatness and fat distribution (waist circumference, waist/hip ratio, body mass index, and subscapular skinfold) and serum lipids (total cholesterol, LDL-cholesterol, triglycerides). Gamma-glutamyl transferase and body mass index both made independent contributions to the explanation of the waist/hip ratio. In multiple regression analysis, gamma-glutamyl transferase levels were (after adjustment for waist/hip ratio and body mass index) associated with serum lipids (total cholesterol, LDL-cholesterol, and triglycerides), but not with HDL-cholesterol and blood pressure. Body mass index only showed an independent relation to triglyceride levels, whereas the waist/hip ratio was only associated with diastolic blood pressure in multiple regression. It is concluded that gamma-glutamyl transferase levels are a potentially important indicator of abdominal fat distribution and unfavourable lipoprotein profiles.
authors.affiliation: Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Barneveld
authors.forename: J C
authors.initials: JC
authors.lastname: Seidell
authors.forename: N
authors.initials: N
authors.lastname: Traag
authors.forename: J G
authors.initials: JG
authors.lastname: Hautvast
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000201:enzymology; D000328:Adult; D000428:Alcohol Drinking; D000886:Anthropometry; D001794:Blood Pressure; D015992:Body Mass Index; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D008055:Lipids; D005723:gamma-Glutamyltransferase