title: Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels.
abstract: Literature data indicate a reduced calcium uptake in synaptosomes prepared from old rat brains. On this line, the present paper investigates the binding of ([3H]NDP) to brain synaptic membranes prepared from rats at different ages from birth up to 24 months of age. The binding is undetectable at birth but reaches within 9-18 day the values observed in adults [3H]NDP binding affinity and sensitivity to calcium were decreased in old rats (24 months). Tritiated dihydropyridines are believed to label voltage-dependent calcium channels (VDC). The observed age-related reduction in binding suggests that the characteristics of VDC in the aged brain may change.
authors.forename: S
authors.initials: S
authors.lastname: Govoni
authors.forename: R A
authors.initials: RA
authors.lastname: Rius
authors.forename: F
authors.initials: F
authors.lastname: Battaini
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: Trabucchi
mesh_terms: D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000378:metabolism; D009568:Nitrendipine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007473:Ion Channels; D009568:Nitrendipine; D009543:Nifedipine; D002118:Calcium