The pharmacological and pathological studies on several hepatic protective crude drugs from Taiwan (II).
Four crude drug extracts of Solanum incanum (entire plant), Ixeris chinensis (entire plant), Gardenia jasminoides (wild and cultivated, fructus) were administered to rats as dose of 1.0 g/kg, I.P. injection to screen the liver protective effect on CC14 induced hepatotoxicity. The acute increase of transaminase SGOT and SGPT levels that was caused by CC14 (1.0 ml/kg) S.C. injection can be significantly improved when treated with Solanum incanum (p less than 0.005), Ixeris chinensis (p less than 0.001), Gardenia jasminoides (cultivated) (p less than 0.005) but only a moderate change was shown by means of wild Gardenia jasminoides (p less than 0.05). As our results indicated, the extraction of these drugs has been found to possess a marked hepatic protective effect. The hepatic fatty metamorphosis and necrosis of central lobule were obviously improved by S. incanum and I. chinensis, administration, while the effect of treatment with G. jasminoides (cultivated) demonstrated a moderate protective action and little histopathological change by G. jasminoides (wild). In contrast to B. chinese, which has been reported previously as a treatment criteria, the S. incanum (p less than 0.01) and I. chinensis (p less than 0.01) in the present study have indicated that a significantly different hepatic protective effect on CC14 induced hepatic injury.
Chiu
H F
HF
Department of Pharmacology, School of Medicine, Kaohsiung Medical College, Taiwan.
Lin
C C
CC
Yang
C C
CC
Yang
F
F
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013624:Taiwan
D004365:Drugs, Chinese Herbal