Acute monocytic leukemia with B cell markers expression following B chronic lymphocytic leukemia.
A case of chronic lymphocytic leukemia (CLL) treated with chlorambucil, followed by the development of an acute monoblastic leukemia, is described. Cytofluorometric quantitative immunophenotype was determined during the blastic phase. Whereas small lymphocytes displayed a CD19+; CD24+; CD37+; CD5+ phenotype, the blastic population exhibited, besides CD13, CD14 and CD15 positivity, which is usually noted in such a monoblastic leukemia, definite CD9, CD10, CD22, CD24, CD37, CD5 and CD4 staining. Such results argue against a complete independence between the two clones, although their similarity could not be demonstrated.
Lavabre-Bertrand
T
T
Service des Maladies du Sang, Hôpital Lapeyronie, Montpellier, France.
Donadio
D
D
Breton
A
A
Taib
J
J
Charlier
D
D
Assens
C
C
Poncelet
P
P
Murgue
B
B
Vendrell
J P
JP
Emberger
J M
JM
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002699:Chlorambucil / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications*; D007948:Leukemia, Monocytic, Acute / Q000097:blood* / Q000150:complications; D007958:Leukocyte Count; D008297:Male; D010641:Phenotype; D010976:Platelet Count
D002699:Chlorambucil