[Inhibition of replication of human hepatitis B virus].
Several nucleoside 5'-triphosphate analogs were investigated as inhibitors of human hepatitis B virus replication. Different analogs inhibited DNA synthesis differently, 3'-azido-2',3'-dideoxythymidine 5'triphosphate being the most active compound. This inhibitor blocked DNA synthesis by 50% at inhibitor: substrate molar ratio 1:8, and by 80% - at 1:1. The hypothesis is formulated that 3'-azido-2',3'-dideoxythymidine 5'-triphosphate inhibits RNA directed viral DNA replication due to incorporation of this compound into 3'-termini of newly synthesized DNA chains. The phenomenon observed opens new possibilities for chemotherapy of acute and chronic human hepatitis B.
Tsibinogin
V V
VV
Kraevskiĭ
A A
AA
Bibilashvili
R Sh
RSh
Gren
E Ia
EIa
Kiselev
L L
LL
D000998:Antiviral Agents; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000187:drug effects; D004587:Electrophoresis, Agar Gel; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology*
D000998:Antiviral Agents; D004279:DNA, Viral; D015215:Zidovudine
Ingibirovanie replikatsii virusa gepatita v cheloveka.