[Typical spontaneous changes in heart rate in pheochromocytoma].
Investigations in 13 hospitalized patients with pheochromocytomata showed peculiar characteristics of heart rate variation at rest, when compared with normals. All patients were given alpha- and beta-sympatholytic drugs. In one case alpha-methyl-Tyrosine caused I-II degree AV blocks and a stable high frequency sinus rate without physiological variations. Resting heart rate in pheochromocytoma varied interindividually from 55-105/min, in the absence of clinical attacks of the underlying disease. The frequency profile was characterized in 12 patients by sudden and inadequate rises of heart rate (200%) of short duration, which were often recorded within 20 seconds of the onset of muscular activity. A similar but less pronounced heart rate modulation was found 1-2 weeks after operation in 3 cases. Our observations indicate that the heart rate profile described may be a sensitive parameter of dysfunction of the autonomous nervous system in pheochromocytoma. Whether the heart rate characteristics are of diagnostic value has to be assessed by further studies.
Bramann
H U
HU
Zidek
W
W
Vetter
H
H
Grosse-Heitmeyer
W
W
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D001281:Atrial Fibrillation / Q000175:diagnosis; D001794:Blood Pressure; D005117:Cardiac Complexes, Premature / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000175:diagnosis; D006339:Heart Rate; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000652:urine; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis; D013610:Tachycardia / Q000175:diagnosis
D008676:Metanephrine
Typische Spontanänderungen der Herzfrequenz bei Phäochromozytom.