title: Study on the origin of major histocompatibility complex (MHC) genes in recombinant mouse strains by detection of polymorphic variants of MHC class III gene, complement C4.
abstract: In recombinant mouse strains the elements of the major histocompatibility complex gene cluster are composed of those of the parental strains. The origin of elements except the S region was previously determined by immunological and biochemical typing methods. For determination of the origin of the S region and the possible location of the recombination event around the S region, Southern blot analysis was performed. By the detection of genetic polymorphic patterns of complement C4 gene in 2 of the 5 recombinant strains the recombination was localized down-stream of the C4 gene and before the D gene region.
authors.affiliation: Immunology Department, National Institute of Rheumatology and Physiotherapy, Budapest.
authors.forename: A
authors.initials: A
authors.lastname: Falus
authors.forename: C S
authors.initials: CS
authors.lastname: David
mesh_terms: D000818:Animals; D003181:Complement C4 / Q000235:genetics*; D014644:Genetic Variation; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
chemical_list: D003181:Complement C4