Fibroblast growth factor pretreatment reduces epidermal growth factor-induced proliferation in rat astrocytes.
Epidermal Growth Factor (EGF) is mitogenic for purified rat astrocytes in primary tissue culture. A combined concomitant treatment by EGF and Fibroblast Growth Factor (FGF) does not reduce the proliferation effect of EGF, however when the astrocytes are pretreated with FGF, their response to an EGF stimulation is reduced by 70%. This inhibition of EGF stimulation by FGF pretreatment is consistent across the EGF dose response curve and perhaps represents a mechanism for local modulation of astrocyte mitogenic effects.
Huff
K R
KR
Div. of Neurology, Childrens Hospital of Los Angeles, Univ. Southern California School of Medicine 90027.
Schreier
W
W
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D004261:DNA Replication / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D013936:Thymidine