title: Cardiovascular responses of rats to electrical stimulation of the fastigial nucleus and local microinjection of amino acids.
abstract: The cardiovascular response to electrical stimulation of the fastigial nucleus (FN) and microinjection of L-glutamate, kainic acid, glycine and GABA into the FN of anesthetized rats were studied. Electrical stimulation of FN produced pressor or depressor responses with a decrease or no change in heart rate depending upon the intensity or site of the stimulation. Microinjection of L-glutamate or kainic acid into the FN elicited pressor or depressor response with bradycardia, while that of glycine or GABA did not affect blood pressure or heart rate. L-glutamate or kainic acid microinjected into the FN did not affect epinephrine-induced pressor response, but attenuated the bradycardic response. These results indicate that L-glutamate in the FN may play a role in modulation of the cardiovascular regulation.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
authors.forename: T F
authors.initials: TF
authors.lastname: Huang
authors.forename: Y I
authors.initials: YI
authors.lastname: Peng
authors.forename: J Y
authors.initials: JY
authors.lastname: Shieh
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced / Q000517:prevention & control; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002529:Cerebellar Nuclei / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D004837:Epinephrine; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006339:Heart Rate / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D051381:Rats
chemical_list: D000596:Amino Acids; D005971:Glutamates; D018698:Glutamic Acid; D007608:Kainic Acid; D004837:Epinephrine