Resistance development to fluoroquinolones in Europe.
We did not observe an increase in quinolone-resistant strains in recent years despite a dramatic increase in drug usage. P. aeruginosa strains should be carefully monitored in the future since a trend to increased MICs seems obvious. Epidemiologic data on resistance have to be evaluated carefully, and special interest must be focused on the breakpoint in relation to the normal distribution of MICs. Conclusions can be drawn only if the increased numbers of strains are clearly separated from the normal distribution.
Wiedemann
B
B
Pharmazeutische Mikrobiologie der Universität Bonn, Federal Republic of Germany.
Zühlsdorf
M T
MT
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D005060:Europe; D008826:Microbial Sensitivity Tests
D042462:4-Quinolones; D000890:Anti-Infective Agents