Synthesis and pharmacological properties of diphenylimidazolidine acetic and propionic acids derivatives.
Several derivatives of diphenylimidazolidine-2,4-dione and diphenylimidazolidin-4-one acetic and propionic acids have been synthesized. Some of them were screened for their effect on the CNS in mice and rats. All the investigated compounds showed an analgesic activity. The most active one was 1-benzyl-5,5-diphenyl-3-imidazolidine-2,4-dione acetic acid. That compound exerted an inhibitory activity against the CNS, anxiety-relieving, anticonvulsant and antidepressive effects.
Zejc
A
A
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Kieć-Kononowicz
K
K
Chłoń
G
G
Kleinrok
Z
Z
Kolasa
K
K
Pietrasiewicz
T
T
Czechowska
G
G
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013239:Stereotyped Behavior / Q000187:drug effects
D000085:Acetates; D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007093:Imidazoles; D011422:Propionates