C(3)-cyclopropyl cephems and carbacephems.
A series of C(3)-cyclopropyl cephems and carbacephems has been prepared by palladium catalyzed addition of diazomethane to the corresponding C(3)-vinyl derivatives. The phenylglycyl cyclopropyl cephem derivatives exhibit better Gram-positive activity than cephalexin or cefaclor, while the aminothiazole oxime cyclopropyl cephem derivatives were not as active as the corresponding C(3)-vinyl cephems.
Spry
D O
DO
Lilly Research Laboratory, Eli Lilly & Company, Indianapolis, Indiana 46285.
Snyder
N J
NJ
Kasher
J S
JS
D000818:Animals; D001682:Biological Availability; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D006207:Half-Life; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains
D002511:Cephalosporins; C026739:carbacephems