Antibacterial, antifungal and antitumoral activities of Micromycetes. I. Preliminary study.
The ability of 211 strains of Micromycetes to produce antibiotic, antifungal and antitumoral compounds has been investigated in vitro using test strains and P 388 leukemia cells. Cytotoxicity was determined on Vero cells. Convenient activities were obtained depending on the taxonomic group. Finally, 17 strains of Micromycetes were selected for their antibacterial or antifungal activities and 12 for their antitumoral properties. Investigations are in progress concerning these activities.
Steiman
R
R
Groupe Métabolites d'origine fongique, UFR de Pharmacie, Meylan, France.
Bartoli
M H
MH
Seigle-Murandi
F
F
Boitard
M
M
Beriel
H
H
Villard
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D003603:Cytotoxins / Q000096:biosynthesis / Q000633:toxicity; D005658:Fungi / Q000187:drug effects / Q000378:metabolism*; D007941:Leukemia P388; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D003470:Culture Media; D003603:Cytotoxins