Mucocutaneous complications of intraarterial 5-bromodeoxyuridine and radiation.
5-Bromodeoxyuridine (BUDR), a halopyrimidine thymidine analogue, is incorporated into the DNA of dividing cells and causes photoradiosensitization. Twenty-five patients with malignant astrocytomas were treated with continuous intracarotid BUDR radiosensitization and radiotherapy for 8 1/2 weeks. Unique dose-limiting mucocutaneous complications were encountered. Ipsilateral facial dermatitis with epilation of eyebrows and eyelashes, ocular irritation, and bilateral nail dystrophy developed in all patients. Less common reactions included oral ulceration in six patients, body exanthem on the trunk in five, and atypical erythema multiforme major in one.
McCuaig
C C
CC
Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI 48109-0314.
Ellis
C N
CN
Greenberg
H S
HS
Hegarty
T J
TJ
Page
M A
MA
D000505:Alopecia / Q000209:etiology; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D001973:Bromodeoxyuridine / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003234:Conjunctivitis, Bacterial / Q000209:etiology; D005148:Facial Dermatoses / Q000209:etiology; D006801:Humans; D007261:Infusions, Intra-Arterial; D009059:Mouth Diseases / Q000209:etiology; D009260:Nail Diseases / Q000209:etiology; D011829:Radiation Dosage; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects*; D011855:Radiodermatitis / Q000209:etiology* / Q000628:therapy; D011859:Radiography; D014456:Ulcer / Q000209:etiology
D011838:Radiation-Sensitizing Agents; D001973:Bromodeoxyuridine