title: The Epstein-Barr virus receptor on two nasopharyngeal carcinoma model cell lines.
abstract: It was reported that the OKB7 monoclonal antibody to C3d receptor could directly inhibit Epstein-Barr virus (EBV) attachment to and infection of B-lymphocytes. So we tested whether the OKB7 could inhibit superinfection of two epithelial NPC model cell lines (D98/HR-1 and NPC-KT) with EBV. Pretreatment of B-lymphocytes with the OKB7 significantly inhibits EBV infection. However, pretreatment with the OKB7 had no effect on superinfection of D98/HR-1 and NPC-KT cells. These data suggest that an EBV receptor, unrelated to C3d receptor, exists.
authors.affiliation: Department of Otolaryngology, School of Medicine, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takimoto
authors.forename: R
authors.initials: R
authors.lastname: Umeda
authors.forename: R
authors.initials: R
authors.lastname: Glaser
mesh_terms: D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D015933:Complement C3d / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000382:microbiology*; D011951:Receptors, Complement / Q000276:immunology; D017464:Receptors, Complement 3d; D011991:Receptors, Virus / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000382:microbiology
chemical_list: D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D011951:Receptors, Complement; D017464:Receptors, Complement 3d; D011991:Receptors, Virus; D015933:Complement C3d