[Synthesis of new derivatives of 5H-furo[3,2-g][1]benzopyran-5-one with potential beta-adrenolytic activity].
With the purpose of obtaining new compounds with antiarrhythmic activity, nine novel aminoalkanol derivatives of 5H-furo[3,2-g] [1]benzopyran-5-one were synthetized. In pharmacological studies, compound IX proved to display strong antiarrhythmic action, which in chloroform-induced arrhythmia was stronger from that of propranolol at three times lower acute toxicity.
Zawadowski
T
T
Turło
J
J
Borkowska
G
G
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D001578:Benzopyrans; C063951:5H-furo(3,2-g)(1)benzopyran-5-one
Synteza nowych pochodnych 5h-furo [3-2-g] [1]-benzopiran-5-onu o spodziewanym działaniu beta-adrenolitycznym.