Inotropic response elicited by nematocyst contents of Hydra oligactis (Coelenterata: Hydrozoa).
1. Intact, isolated nematocysts from the non-toxic, freshwater coelenterate Hydra oligactis contain soluble material(s) capable of producing a sustained increase in the rate of developed force in the vertebrate myocardium. 2. The positive inotropic effects of this material(s) appear grossly comparable to those described for Anthopleurin-A (AP-A) and Toxin II (ATX-II) from sea anemones. 3. The effects of the nematocyst material are distinct from those of known vasoactive peptides reported to occur in Hydra.
Lesh-Laurie
G E
GE
Department of Biology, Cleveland State University, Ohio 44115.
DiBlasi
S L
SL
Suchy
P E
PE
Senturia
J B
JB
D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006829:Hydra / Q000032:analysis* / Q000166:cytology; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D014426:Turtles
D002316:Cardiotonic Agents