title: Regional blood flow during extracorporeal membrane oxygenation in lambs.
abstract: To determine changes in blood flow to different organs during extracorporeal membrane oxygenation (ECMO), the authors performed venoarterial ECMO in four young lambs for 71-96 hr (Group 1). Macroaggregated albumin microspheres labeled with technetium 99m were injected through the perfusion cannula before termination of ECMO to determine percent of blood flow by measuring radioactivity from the microspheres lodged in specific organs. The control group (Group 2) consisted of three animals not on bypass; injections were made through a catheter placed in the left ventricle. Relative coronary blood flow from the perfusion cannula was significantly less than relative coronary blood flow in the control group, possibly because of cannula location. Renal flow from the perfusion cannula also was decreased. Contrary to observations in rabbits, cerebral perfusion did not decrease in the bypass group despite ligation of the carotid artery and the external jugular vein. There were no statistically significant differences between the two groups in the relative blood flow to other organs. The authors conclude that ECMO may significantly alter myocardial and renal perfusion, with minimal effects to other organs.
authors.affiliation: Department of Surgery, School of Medicine, Wayne State University, Detroit, Michigan.
authors.forename: H G
authors.initials: HG
authors.lastname: Smith
authors.forename: G C
authors.initials: GC
authors.lastname: Whittlesey
authors.forename: S K
authors.initials: SK
authors.lastname: Kundu
authors.forename: S O
authors.initials: SO
authors.lastname: Salley
authors.forename: L R
authors.initials: LR
authors.lastname: Kuhns
authors.forename: C H
authors.initials: CH
authors.lastname: Chang
authors.forename: M D
authors.initials: MD
authors.lastname: Klein
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology; D015199:Extracorporeal Membrane Oxygenation; D008102:Liver Circulation / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology; D012756:Sheep; D013154:Spleen / Q000098:blood supply