title: Pharmacology of narcotic analgesics.
abstract: Opioid receptors are described and differentiated by their affinities for specific agonists and antagonists. Their sites of action and receptor activities are discussed. Tachyphylaxis and tolerance are described and methods for overcoming these problems are recommended. Suggestions are made regarding future drugs to act at specific receptors.
authors.affiliation: University of Virginia Medical Center, Charlottesville.
authors.forename: C A
authors.initials: CA
authors.lastname: DiFazio
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D011957:Receptors, Opioid