Comparison of the H-2Kb-specific cytolytic T lymphocyte receptor repertoire in Igh recombinant strains.
Previous studies in which the H-2Kb-specific cytolytic T lymphocytes (CTL) receptor repertoires were compared for murine strains that express different Igh alleles (C.B-20 and BALB/c) indicated that Igh-linked genes affected the composition of the expressed CTL receptor repertoire. To confirm this genetic localization, and also to individually assess the contributions of Igh-V- and Igh-C-linked genes to CTL repertoire expression, the H-2Kb-specific responses of two Igh recombinant strains, BAB/14 (Igh-Va-Cb) and C.B/R3 (Igh-Vb-Ca), were analyzed. The results indicate that strains which share Igh-V (but not Igh-C) genes demonstrate significant repertoire similarities, whereas strains which share Igh-C (but not Igh-V) are no more similar than strains dissimilar throughout the Igh complex. These results are discussed in the context of the existence of a naturally occurring idiotypic network involving immunoglobulin and CTL receptors.
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D000818:Animals; D002999:Clone Cells / Q000276:immunology; D000939:Epitopes / Q000235:genetics; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D064532:Histocompatibility Antigen H-2D; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism*
D000939:Epitopes; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D011948:Receptors, Antigen, T-Cell