title: Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.
abstract: Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuraishi
authors.forename: N
authors.initials: N
authors.lastname: Hirota
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Hino
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D000818:Animals; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010812:Physical Stimulation; D011817:Rabbits; D013004:Somatostatin / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission; D013823:Thermoreceptors / Q000502:physiology
chemical_list: D013373:Substance P; D013004:Somatostatin