title: Auditory P300 does not differentiate borderline personality disorder from schizotypal personality disorder.
abstract: The P300 response to an auditory two-tone discrimination task has previously been reported to have prolonged latency and reduced amplitude in schizophrenia and borderline personality disorder. In this study, P300 was recorded from 23 subjects with borderline personality disorder, 12 subjects fulfilling criteria for both borderline and schizotypal personality, and 11 subjects with schizotypal personality. The mean P300 latency was similar in each of these groups and was significantly longer than in 32 patients with neuroses and other personality disorders and 74 nonpatient controls. These findings suggest that borderline and schizotypal patients share a similar abnormality in auditory stimulus evaluation and question whether or not these disorders are separate.
authors.affiliation: Department of Psychiatry, Sunnybrook Medical Centre, University of Toronto, Canada.
authors.forename: S P
authors.initials: SP
authors.lastname: Kutcher
authors.forename: D H
authors.initials: DH
authors.lastname: Blackwood
authors.forename: D F
authors.initials: DF
authors.lastname: Gaskell
authors.forename: W J
authors.initials: WJ
authors.lastname: Muir
authors.forename: D M
authors.initials: DM
authors.lastname: St Clair
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000295:instrumentation; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010897:Pitch Discrimination / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D012815:Signal Processing, Computer-Assisted
chemical_list: D011619:Psychotropic Drugs