Studies on some biological differences between the chiral forms of methyl-1-naphthyl-p-nitrophenyl phosphorothionate.
A general degranulation test for carcinogens using the postmitochondrial supernatant (PMS) was based on the consistency of the stripping of ribosomes from rough endoplasmic reticulum. The degranulation phenomenon has been classified into three types, which are D1A, D1B and D11. This classification which is new has been introduced to probe more into the mechanistic aspects of degranulation. Aflatoxin B1 dimethylnitrosamine, 2-acetylaminofluorene, and 4-dimethylaminobenzene were carcinogens, evaluated in the PMS system. Reduced glutathione (GSH), oxidized glutathione (GSSG), sodium chloride, potassium chloride, lithium chloride, lithium carbonate, and ascorbic acid which are noncarcinogens and the (+) and (-) chiral forms of methyl-1-naphthyl-p-nitrophenyl phosphorothionate were also evaluated in the PMS system. Lithium carbonate is teratogenic in rats. Similar findings have also been reported in mice, and lithium ion has been confirmed to be teratogenic in mice. This biological phenomenon of the D11 type could well evolve as a teratogenic effect and not a carcinogenic effect.
Akintonwa
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D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity; D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects; D063086:Organothiophosphates / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011132:Polyribosomes / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013045:Species Specificity
D000348:Aflatoxins; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D011506:Proteins; D012313:RNA; C045129:methyl-1-naphthyl-4-nitrophenyl phosphorothionate; D016604:Aflatoxin B1; D005978:Glutathione