[Reasons for the use of mydocalm in the prevention and treatment of antibiotic-induced sensorineural hearing loss].
The applicability of mydocalm for the prevention and therapy of hypoacusis caused by kanamycin, an antibiotic of the aminoglycoside series, was investigated in animal (guinea-pig) experiments. The changes in nucleic acids and nuclear size of the spiral organ were used as parameters. Hearing loss as shown by the lack of Preyer's reflex developed in response to kanamycin injected at a dose of 50 mg/kg/day for 14 days. In the spiral organ nuclei of hair cells were in the state of functional shrinkage. The use of mydocalm at a dose of 12 mg/kg in parallel with or after kanamycin injection nuclei of receptor cells did not shrink, Preyer's reflex did not disappear (in the case of parallel administration of mydocalm and kanamycin) or recovered (in the case of mydocalm administration after kanamycin injection). In summary, mydocalm as a vasoactive and neurotrophic drug can be used for the prophylaxis and therapy of hypoacusis caused by aminoglycoside antibiotics and can be recommended for practical application.
Lantsov
A A
AA
Anichin
V F
VF
Alibekov
I M
IM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000166:cytology / Q000187:drug effects; D006199:Hair Cells, Auditory, Inner / Q000166:cytology / Q000187:drug effects; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control; D007612:Kanamycin / Q000008:administration & dosage / Q000009:adverse effects; D007620:Karyometry; D008954:Models, Biological; D009696:Nucleic Acids / Q000032:analysis; D009925:Organ of Corti / Q000166:cytology / Q000187:drug effects; D011427:Propiophenones / Q000627:therapeutic use*; D014049:Tolperisone / Q000008:administration & dosage / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D009696:Nucleic Acids; D011427:Propiophenones; D007612:Kanamycin; D014049:Tolperisone
Obosnovanie primeneniia midokalma pri profilaktiki i lecheniia neĭrosensornoĭ tugoukhosti antibiotikovoĭ étiologii.