title: [Adenomatous hyperplasia--hysterectomy or drug therapy?].
abstract: Adenomatous hyperplasia of the endometrium requires either gestagen treatment or hysterectomy, depending on the patient's age and grade of hyperplasia. 51 patients, in whom adenomatous hyperplasia of grade I-III had been ascertained by curettage, were hysterectomized not more than 4 weeks following diagnosis at the Kiel University Clinic of Obstetrics and Gynecology during the years 1985-1989. Only few of the patients received hormone treatment. For all grades of hyperplasia, histological findings from curettage and hysterectomy were identical in only 40% of the cases. In patients older than 40 years, 54% of 13 patients with adenomatous hyperplasia grade III in the curettage specimen had already developed a well differentiated adenocarcinoma, which was detected in the extirpated uterus. In our opinion, when adenomatous hyperplasia of grade II or III is present in a curettage specimen in the age group over 40 years women, hysterectomy should be recommended. For younger women and for adenomatous hyperplasia grade I, we recommend individual therapy.
authors.affiliation: Abteilung Frauenheilkunde im Zentrum für Operative Medizin I der Christian-Albrechts-Universität zu Kiel.
authors.forename: H
authors.initials: H
authors.lastname: Mecke
authors.forename: P
authors.initials: P
authors.lastname: Kunstmann
authors.forename: E
authors.initials: E
authors.lastname: Lehmann-Willenbrock
authors.forename: K
authors.initials: K
authors.lastname: Semm
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011230:Precancerous Conditions / Q000188:drug therapy / Q000601:surgery*; D011372:Progestins / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery*
chemical_list: D011372:Progestins
vernacular_title: Adenomatöse Hyperplasie--Hysterektomie oder medikamentöse Therapie?