title: Genetic hemochromatosis: distribution analysis of six laboratory measures of iron metabolism.
abstract: Six laboratory measures of iron metabolism were studied in a control sample, and a family sample was ascertained on the basis of probands with clinically diagnosed genetic hemochromatosis. The respective distribution of each variable evidenced a mixture of components, presumably arising from the segregation of an HLA-linked locus for hemochromatosis. There were significant differences in the distributional characteristics with respect to sex and genotype-specific variances. These aspects of the data have important implications for subsequent segregation and linkage analyses, which traditionally assume homoscedasticity and homogeneity of the genetic effect.
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: I B
authors.initials: IB
authors.lastname: Borecki
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: L
authors.initials: L
authors.lastname: Le Mignon
authors.forename: J
authors.initials: J
authors.lastname: Yaouanq
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
mesh_terms: D003676:Deferoxamine; D005260:Female; D005293:Ferritins / Q000097:blood; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006432:Hemochromatosis / Q000097:blood / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D012737:Sex Factors; D012984:Software; D014168:Transferrin / Q000032:analysis
chemical_list: D006680:HLA Antigens; D014168:Transferrin; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine