Inherited deficiencies of the late-acting complement components other than C9 found among healthy blood donors.
Among sera from 145,640 healthy blood donors in Osaka, 16 were found to have abnormalities in late-acting complement components other than C9. It was found that of these 16 sera, 2 were deficient in C5, 4 in C6, 6 in C7 and 4 in C8 alpha-gamma-subunit. The incidence of deficiency of each component among the Osaka blood donors was calculated as follows: C5 deficiency, 0.0014%; C6 deficiency, 0.0027%; C7 deficiency, 0.0041%; C8 alpha-gamma-subunit deficiency, 0.0027%. We confirmed that 13 donors were healthy and 12 had no past history related to a complement component deficiency. From these results, not only C9 deficiency but also deficiencies of the other late-acting complement components were found among the healthy blood donors, but no early-acting component deficiencies were noted.
Inai
S
S
Department of Clinical Pathology, Osaka Medical College, Japan.
Akagaki
Y
Y
Moriyama
T
T
Fukumori
Y
Y
Yoshimura
K
K
Ohnoki
S
S
Yamaguchi
H
H
D001782:Blood Donors; D003167:Complement Activation; D003182:Complement C5 / Q000172:deficiency / Q000235:genetics; D003183:Complement C6 / Q000172:deficiency; D003184:Complement C7 / Q000172:deficiency; D003185:Complement C8 / Q000172:deficiency; D003186:Complement C9 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D006461:Hemolysis; D006801:Humans; D007564:Japan; D010375:Pedigree
D003182:Complement C5; D003183:Complement C6; D003184:Complement C7; D003185:Complement C8; D003186:Complement C9; D003165:Complement System Proteins