Novel [D-Pen2, D-Pen5]enkephalin derivatives with increased sigma receptor potency and selectivity: potential tools for opioid pharmacology.
Burks
T F
TF
Department of Pharmacology, University of Arizona, Tucson 85724.
Kramer
T H
TH
Davis
P
P
Toth
G
G
Hruby
V J
VJ
D000701:Analgesics, Opioid; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D020881:Enkephalin, D-Penicillamine (2,5)-; D004745:Enkephalins / Q000494:pharmacology*; D006168:Guinea Pigs; D051379:Mice; D009619:Nociceptors / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid; D004745:Enkephalins; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D020881:Enkephalin, D-Penicillamine (2,5)-