The effect of bradykinin and its fragments on the arachidonate cascade of brain microvessels.
The lipoxygenase pathway dominated the arachidonate cascade in the microvessels isolated from cerebral cortical microvessels of male rats. Bradykinin significantly reduced the lipoxygenase pathway and the synthesis of PGD2 in the microvessels of rats. The synthesis of vasoconstrictor cyclooxygenase metabolites was stimulated with Ser-Pro-Phe-Arg tetrapeptide in the cerebral capillaries while the Phe-Arg dipeptide stimulated the release of arachidonate metabolites. The arachidonate cascade was shifted to the cyclooxygenase pathway with angiotensin III in cerebral microvessels. Kallikrein stimulated the lipoxygenase pathway and the synthesis of vasoconstrictor cyclooxygenase metabolites.
Gecse
A
A
Department of Pathophysiology, Szent-Györgyi Albert Medical University Szeged, Hungary.
Mezei
Z
Z
Telegdy
G
G
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D002851:Chromatography, High Pressure Liquid; D015777:Eicosanoids / Q000096:biosynthesis / Q000302:isolation & purification; D007610:Kallikreins / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D015777:Eicosanoids; D010446:Peptide Fragments; D000804:Angiotensin II; D007610:Kallikreins; D001920:Bradykinin