An intercalative and minor groove binding model for the DNA cleavage reagent, copper(I) (1,10-phenanthroline)2.
On account of the stereochemical structure and interaction characteristics of the DNA cleavage reagent copper(I) (1,10-phenanthroline)2, both intercalative and minor groove binding modes to B-DNA could be expected to occur. In the proposed model, the suitable dihedral angle between phenanthrolines allows that one of the two planar ligands partially intercalates between base pairs, and meanwhile the other ligand locates along the minor groove.
Stockert
J C
JC
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003432:Cross-Linking Reagents; D004247:DNA; D008958:Models, Molecular; D010618:Phenanthrolines
D003432:Cross-Linking Reagents; D010618:Phenanthrolines; D004247:DNA; C025205:1,10-phenanthroline