[Lipid peroxidation and the functioning of the Ca pump of the sarcoplasmic reticulum of skeletal muscle in hypercholesterolemia].
During prolonged hypercholesterolemia (HCh), there was a reduction in the efficacy of Ca-pump function of the sarcoplasmic reticulum (SR) of rabbit skeletal muscles, an increase in cholesterol content, and intensification of lipid peroxidation in SR membranes. Supplementation of the cholesterol-rich diet with alpha-tocopherol effectively prevented dysfunction of the SR Ca-pump and reduced the enhanced LPO level in SR membranes without having any effect on cholesterol content in blood serum and SR membranes. The increase in the LPO level seems likely to be primarily responsible for abnormalities in the SR Ca-pump during HCh.
Timofeev
A A
AA
Kuz'mina
I L
IL
Azizova
O A
OA
Chernysheva
G V
GV
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D002791:Cholesterol, Dietary; D007473:Ion Channels; D008054:Lipid Peroxides; D014810:Vitamin E; D002784:Cholesterol; D024502:alpha-Tocopherol; D024505:Tocopherols; D002118:Calcium
Perekisnoe okislenie lipidov i funktsionirovanie Ca-nasosa sarkoplazmaticheskogo retikuluma skeletnykh myshts pri giperkholesterinemii.