A model for the oxygen-paradox in mouse cardiac muscle.
1. Mouse ventricle strips provide a good model system for studying cellular damage in mammalian cardiac muscle. 2. Anoxia rapidly causes destruction of the myofilament apparatus that is characteristic of calcium-triggered damage in muscle cells, and it is suggested that anoxia promotes release of calcium from the mitochondria. 3. Oxygen exacerbates this damage which is independent of extracellular calcium; it is suggested that it initiates myofilament damage by activation at an intracellular site, probably the sarcoplasmic reticulum.
Duncan
C J
CJ
Department of Zoology, University of Liverpool, UK.
Rudge
M F
MF
D000818:Animals; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000473:pathology*; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D010100:Oxygen / Q000494:pharmacology*
D010100:Oxygen