Behavioral performance and seizure activity of lithium-intoxicated Sprague-Dawley rats treated with theophylline.
Male Sprague-Dawley rats were divided into four groups that were treated with various combinations of lithium, saline, and theophylline, i.e., saline/saline, saline/theophylline, lithium/theophylline, and lithium/saline. Neurobehavioral testing of cerebellar and neuromuscular functioning, and determination of the effect of the drug combinations on the animals' seizure threshold concluded that while theophylline increases lithium clearance, it does not exacerbate lithium neurotoxicity.
Andersen
K H
KH
Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
Perry
P J
PJ
Sherman
A D
AD
Kathol
R G
RG
D015097:3-Mercaptopropionic Acid / Q000009:adverse effects; D000818:Animals; D004347:Drug Interactions; D008094:Lithium / Q000493:pharmacokinetics / Q000506:poisoning*; D008297:Male; D008657:Metabolic Clearance Rate; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*; D013806:Theophylline / Q000494:pharmacology*
D008094:Lithium; D015097:3-Mercaptopropionic Acid; D013806:Theophylline