Effects of cryptolepine alone and in combination with dipyridamole on a mouse model of arterial thrombosis.
The effects of cryptolepine alone and in combination with other antiplatelet agents have been investigated using a mouse model of arterial thrombosis. Intraperitoneal premedication with crytolepine produced 25% maximal protection at 1 mg/kg while dipyridamole producedd a 20% maximal effect at 2 mg/kg. Higher doses of cryptolepine showed a reduced effect. In contrast, indomethacin and aspirin produced a dose-related and higher degree of protection. A combination of cryptolepine and dipyridamole was more effective than when the individual drugs were used alone. The use of 20% ethanol as a dosage vehicle enhanced the protective effects of all drugs tested and the ethanol vehicle alone provided 45% protection.
Oyekan
A O
AO
Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
Okafor
J P
JP
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology*; D005343:Fibrinolytic Agents; D026121:Indole Alkaloids; D007211:Indoles; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D011804:Quinolines
D000317:Adrenergic alpha-Antagonists; D000470:Alkaloids; D005343:Fibrinolytic Agents; D026121:Indole Alkaloids; D007211:Indoles; D011804:Quinolines; C024015:cryptolepine; D004176:Dipyridamole; D001241:Aspirin; D007213:Indomethacin