[Gamma-glutamyltranspeptidase activity and glutathione content in the mammary gland during the processes of pregnancy and lactation in chronically malnourished rats].
The influence of early and chronically dietary protein and energy restriction on gamma glutamyl transpeptidase (GGTP: E.C.2.3.2.2.) activity of the mammary gland of pregnant and lactating rats, was studied. Rats fed a restricted amount of a 25% casein diet throughout gestation and lactation decreased mammary gland weight, DNA, and protein content. The GGTP activity in the mammary gland of the malnourished group was significantly decreased during all of the experimental trial period, and a decrease of offspring weight gain was also observed in that group. The inhibition of GGTP activity in the mammary gland caused by effects of maternal protein and energy undernutrition, could have depressed mammary uptake of amino acids, suggesting a reduced milk protein content and/or milk output.
Araya
J
J
Facultad de Medicína de la Universidad de Chile, Santiago.
Ramos
G
G
Aguilera
A M
AM
Paz Aguilera
C
C
Villalonga
D
D
D000818:Animals; D001835:Body Weight; D004032:Diet; D005260:Female; D005508:Food Deprivation; D005978:Glutathione / Q000032:analysis*; D007774:Lactation / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D009748:Nutrition Disorders / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D005723:gamma-Glutamyltransferase; D005978:Glutathione
Actividad de gama glutamil transpeptidasa y contenido de glutatión en la glandula mamaria durante el progreso de la preñex y la lactancia en ratas cronicamente desnutridas.