The effect of sufentanil on intracranial pressure (ICP) in anesthetized dogs.
The use of sufentanil in neuroanesthesia has been questioned because of a potential increase in intracranial pressure (ICP) in dogs and humans. The effect of sufentanil administration on ICP was studied in 6 dogs with normal and elevated baseline ICP, anesthetized with nitrous oxide and an intravenous piritramide infusion. No significant change in ICP could be demonstrated over a 30 minute observation period after administration of 2 micrograms/kg of sufentanil. The results indicate that this dose of sufentanil does not increase ICP in moderately hyperventilated dogs under stable anesthetic conditions.
Van Hemelrijck
J
J
Department of Anesthesiology, Katholieke Universiteit Leuven, University Hospitals, Belgium.
Mattheussen
M
M
Wüsten
R
R
Lauwers
T
T
Van Aken
H
H
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000768:Anesthesia, General; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007427:Intracranial Pressure / Q000187:drug effects*; D017409:Sufentanil
D000701:Analgesics, Opioid; D017409:Sufentanil; D005283:Fentanyl