The structure of vacidin A, an aromatic heptaene macrolide antibiotic. I. Complete assignment of the 1H NMR spectrum and geometry of the polyene chromophore.
The constitution of vacidin A, a representative of the aromatic heptaene macrolide antibiotics was established on the basis of 13C and 1H-1H double quantum filtered correlated spectroscopy, rotating frame nuclear Overhauser effect spectroscopy, J-resolved 1H as well as 1H-13C correlation NMR spectra. Geometry of the polyene chromophore was determined as 22E,24E,26E,28Z,30Z,32E,34E.
Sowiński
P
P
Department of Pharmaceutical Technology and Biochemistry Technical University of Gdańsk, Poland.
Gariboldi
P
P
Czerwiński
A
A
Borowski
E
E
D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives; D002174:Candicidin / Q000031:analogs & derivatives; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011090:Polyenes / Q000032:analysis
D000900:Anti-Bacterial Agents; D011090:Polyenes; D002174:Candicidin; C031985:vacidin A