Induction of DNA-protein crosslinks in melanotic cloudman S91 mouse melanoma cells and EMT6 mouse mammary carcinoma cells by monochromatic 254 and 405 nm light.
The rates of induction of DNA-protein crosslinks (DPC) by monochromatic radiation at 254 and 405 nm were compared in melanotic S91 mouse melanoma cells and EMT6 mouse mammary carcinoma cells. At 254 nm, the rates of induction of DPC are the same in the two cell lines, whereas, at 405 nm, the rate of induction of DPC in the melanotic cells is considerably less than that in the nonmelanotic cells. Since the major difference in the two cell lines with respect to absorption is melanin, the latter finding implies that intracellular melanin can protect against this DNA damage caused by a component of environmental carcinogenic solar radiation.
Hill
H Z
HZ
Department of Radiology, New Jersey Medical School, Newark 07103-2757.
Peak
J G
JG
Peak
M J
MJ
D000818:Animals; D002460:Cell Line; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008027:Light; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D008543:Melanins / Q000032:analysis; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism / Q000528:radiation effects*; D011485:Protein Binding; D014407:Tumor Cells, Cultured / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D008543:Melanins; D009363:Neoplasm Proteins