[Effect of somatostatin and ranitidine in acute hemorrhage of the upper digestive tract].
The effects of Somatostatin and Ranitidine were studied in 46 patients with acute hemorrhages of the upper digestive tract, 23 were medicated with Somatostatin, 12 with acute gastric hemorrhages of medicamental etiology and 11 with ulcers. The doses was 500 micrograms bolus and than infusion of 250 micrograms/h. 23 patients were treated with 300 mg/day I.V. of Ranitidine, 12 had acute gastric hemorrhages also of medicamental etiology and 11 with ulcers. Somatostatin stopped the bleeding in 100% of the patients with hemorrhagic gastritis, meanwhile Ranitidine only in 76%. This is statistically significative (p less than 0.04648). Hemorrhages in patients with ulcers were stopped by Somatostatin in 73% and by Ranitidine in 64%. This is not statistically significative (p = 0.4995). No collateral effects were observed in both groups of patients.
Jorge
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AD
Cátedra de Clínica Médica III, UNC, Mendoza Servicio de Gastroenterología del Hospital Español, Argentina.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D005756:Gastritis / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications; D011899:Ranitidine / Q000627:therapeutic use*; D013004:Somatostatin / Q000627:therapeutic use*
D013004:Somatostatin; D011899:Ranitidine; D001241:Aspirin
Acción de la somatostatina y de la ranitidina en las hemorragias agudas del tracto digestivo superior.