[The effect of the synthetic antioxidant emoxypine on the tonus of the coronary vessels].
Intracoronary administration of emoxypine caused the dose-dependent increase in the average coronary blood flow without changing the parameters of cardiohemodynamics. Emoxypine failed to change the structure of the phase coronary blood flow. When administered at the concentration of 5.10(-4)M emoxypine increased the volume rate of the perfusate outflow from the rat isolated heart cavities and decreased the value of potassium contracture of isolated segments of the coronary vessels. The data obtained indicate the direct coronarolytic action of emoxypine.
Pashin
E N
EN
Shvedova
A A
AA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014655:Vascular Resistance / Q000187:drug effects*
D000975:Antioxidants; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Vliianie sinteticheskogo antioksidanta émoksipina na tonus koronarnykh sosudov.