[Autoimmune reactions against interleukin-2 receptors in patients with blood system diseases and in experimental Rauscher retrovirus leukemia].
Apart from autoimmune reactions, antibodies to IL-2 receptors were identified in blood sera of linear mice during leukemogenesis. It is indicated that in the course of leukemia establishment, there can be demonstrated antibodies capable of blocking IL-2 receptors on the membrane of activated T lymphocytes and inhibiting IL-2-dependent proliferation of T cells. The blood sera of patients suffering from chronic lymphoid leukemia, acute lymphoblastic leukemia, lymphocytomas, pure red-cell aplasia, and aplastic anemia showed antibodies against IL-2 receptors. Out of the total number of 52 patients, 23 demonstrated those antibodies. The data obtained should be taken into account in the patients' management using IL-2.
Ter-Grigorov
V S
VS
Pivnik
A V
AV
Novikov
V A
VA
Mamiliaeva
Z Kh
ZKh
Moskovkina
O Ia
OIa
D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D005260:Female; D006402:Hematologic Diseases / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology*; D051379:Mice; D011925:Rauscher Virus; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015375:Receptors, Interleukin-2
Autoimmunnye reaktsii protiv retseptorov dlia interleĭkina-2 u bol'nykh s nekotorymi zabolevaniiami sistemy krovi i pri éksperimental'nom retrovirusnom leĭkoze Raushera.