title: The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity.
abstract: Intravenous injection of platelet activating factor (PAF) in anesthetized guinea pigs induces non-selective airway hyperreactivity. This response to PAF was reduced in a dose-dependent manner by systemic administration of established prophylactic anti-asthma drugs (ketotifen, cromoglycate, aminophylline and glucocorticosteroids) and by competitive antagonists of PAF. These inhibitory effects could not be accounted for by antagonism of histamine (H1), serotonin or peptidoleukotrienes receptors; parasympatholytic activity; cyclo-oxygenase or lipoxygenase inhibition; mast cell stabilization; or bronchodilatation. Infusion or injection of PAF to induce airway hyperreactivity in the guinea pig may provide a prospective test for prophylactic anti-asthma drugs.
authors.affiliation: Preclinical Research, Sandoz AG, Basel, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Sanjar
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Schaeublin
authors.forename: A
authors.initials: A
authors.lastname: Kristersson
authors.forename: I
authors.initials: I
authors.lastname: Chapman
authors.forename: L
authors.initials: L
authors.lastname: Mazzoni
authors.forename: J
authors.initials: J
authors.lastname: Morley
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control*; D016861:Cyclooxygenase Inhibitors; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D016859:Lipoxygenase Inhibitors; D008168:Lung / Q000187:drug effects / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D010972:Platelet Activating Factor / Q000494:pharmacology*; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D016861:Cyclooxygenase Inhibitors; D006634:Histamine H1 Antagonists; D016859:Lipoxygenase Inhibitors; D010972:Platelet Activating Factor; D012702:Serotonin Antagonists