title: Intraoperative radiation therapy-induced sarcomas in dogs.
abstract: In a canine model the tolerance of normal and surgically manipulated tissue to intraoperative radiotherapy (IORT) was investigated to provide guidelines for the clinical use of IORT in human cancer patients. A dose of 20 Gy IORT, with or without external beam radiotherapy, was generally well tolerated without significant increased treatment morbidity. Higher doses of IORT (over 30 Gy) have produced radiation-induced sarcomas in some animals followed over a long period. Therefore IORT should be used only in human cancer patients in well controlled studies, in which complications are well documented, and the possibility of radiation-induced malignancies in long-term survival should be considered.
authors.affiliation: Department of Surgical Oncology, Groningen University Hospital, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: W F
authors.initials: WF
authors.lastname: Sindelar
authors.forename: T J
authors.initials: TJ
authors.lastname: Kinsella
authors.forename: D M
authors.initials: DM
authors.lastname: Mehta
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology; D006394:Hemangiosarcoma / Q000209:etiology; D007432:Intraoperative Period; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000209:etiology