title: [Radiation and combined treatment of anaplastic neuroepithelial neoplasms].
abstract: The data on 645 patients with anaplastic neuroepithelial tumors subjected to radiotherapy, irradiation with radiosensitizers (metronidazole) and chemoradiotherapy are presented. Total-differential brain irradiation was applied: 10-40 Gy on the whole brain and 10-20 Gy on the tumor bed. Fractionation depended on tumor radiosensitivity. The median survival time for anaplastic astrocytoma was 50 +/- 5.6 mos., oligodendroglioblastoma - 42 +/- 7.4 mos., ependymoblastoma - 61 +/- 8.2 mos. and glioblastoma - 22 +/- 1.5 mos. High-dose dynamic fractionation proved to be most effective in cases of glioblastoma. The outcome of glioblastoma was modified neither by radiosensitizers nor by cytotoxic agents.
authors.forename: V N
authors.initials: VN
authors.lastname: Ragaĭshene
authors.forename: E V
authors.initials: EV
authors.lastname: Iuozaĭtite
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004583:Electrons / Q000627:therapeutic use; D004806:Ependymoma / Q000401:mortality / Q000532:radiotherapy; D005910:Glioma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000401:mortality / Q000532:radiotherapy; D009837:Oligodendroglioma / Q000401:mortality / Q000532:radiotherapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D011879:Radiotherapy Dosage
chemical_list: D000970:Antineoplastic Agents; D003037:Cobalt Radioisotopes; D011838:Radiation-Sensitizing Agents
vernacular_title: Luchevoe i kombinirovannoe lechenie anaplasticheskikh neĭroépitelial'nykh novoobrazovaniĭ.