title: Alaproclate a novel antidepressant? A biochemical and clinical comparison with zimeldine.
abstract: Clinical and biochemical effects of two selective 5-HT uptake inhibitors, zimeldine and alaproclate, were studied in 24 hospitalized patients with endogenous depression. According to a randomized parallel group design 14 patients were treated with zimeldine and 10 with alaproclate. The dosage of both zimeldine and alaproclate was 200 mg daily. For the evaluation of the clinical effect, Montgomery & Asberg Depression Rating Scale (MADRS) was used. Seven of 14 patients treated with zimeldine and seven of 10 treated with alaproclate improved. 5-HT uptake inhibition in patients' platelets and concentration of amine metabolites (5-HIAA, HVA, HMPG) in CSF were studied before and during treatment. After 3 weeks of treatment with zimeldine 5-HIAA and HMPG in CSF decreased significantly while HVA in CSF increased significantly. Zimeldine produced a significant 5-HT uptake inhibition in platelets. During treatment with alaproclate no significant change in amine metabolites concentration in CSF was found and there were no mean changes on 5-HT uptake inhibition in platelets.
authors.forename: A
authors.initials: A
authors.lastname: Aberg-Wistedt
authors.forename: M
authors.initials: M
authors.lastname: Alvariza
authors.forename: L
authors.initials: L
authors.lastname: Bertilsson
authors.forename: R
authors.initials: R
authors.lastname: Malmgren
authors.forename: H
authors.initials: H
authors.lastname: Wachtmeister
mesh_terms: D000328:Adult; D000368:Aged; D000409:Alanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D015031:Zimeldine / Q000009:adverse effects / Q000134:cerebrospinal fluid / Q000627:therapeutic use
chemical_list: D012702:Serotonin Antagonists; D012701:Serotonin; D015031:Zimeldine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; C025293:alaproclate; D000409:Alanine; D006719:Homovanillic Acid