title: Prenatal sex determination by DNA amplification from maternal peripheral blood.
abstract: The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.
authors.affiliation: University of Oxford Clinical School.
authors.forename: Y M
authors.initials: YM
authors.lastname: Lo
authors.forename: P
authors.initials: P
authors.lastname: Patel
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
authors.forename: M
authors.initials: M
authors.lastname: Sampietro
authors.forename: M D
authors.initials: MD
authors.lastname: Gillmer
authors.forename: K A
authors.initials: KA
authors.lastname: Fleming
mesh_terms: D001769:Blood; D005260:Female; D005333:Fetus; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012732:Sex Determination Analysis; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers