Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.
The structure of altemicidin, a new acaricidal and antitumor agent, was determined to be (1R,2S,3aR,7aS)-4-carbamoyl-2-hydroxy-6-methyl-1-(sulfamo ylacetamido)-2,3,3a,6, 7,7a-hexahydro-6-azaindene-1-carboxylic acid by a combination of spectroscopic and X-ray crystallographic analysis of its derivatives. Altemicidin is a monoterpene alkaloid.
Takahashi
A
A
Institute of Microbial Chemistry, Tokyo, Japan.
Ikeda
D
D
Nakamura
H
H
Naganawa
H
H
Kurasawa
S
S
Okami
Y
Y
Takeuchi
T
T
IitakaY
D000470:Alkaloids / Q000032:analysis; D000903:Antibiotics, Antineoplastic / Q000032:analysis; D003461:Crystallography; D007306:Insecticides / Q000032:analysis; D016018:Least-Squares Analysis; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines; D013457:Sulfur Compounds
D000470:Alkaloids; D000903:Antibiotics, Antineoplastic; D007306:Insecticides; D011725:Pyridines; D013457:Sulfur Compounds; C061865:altemicidin