title: An improved method to correct the QT interval of the electrocardiogram for changes in heart rate.
abstract: The adequacy of the Bazett formula to correct for heart rate-induced changes in the QT interval of the electrocardiogram has been frequently questioned. In the present study, a simple linear equation was derived, which in anesthetized dogs corrects more adequately for changes in heart rate than the Bazett formula. Regression analysis of experimental data yielded the following equation: QTc = QT - 0.087 (RR - 1000) = QT - 87 (60/HR - 1). The reliability of this equation was investigated in experiments on anesthetized dogs with different cardioactive drugs with a known mechanism of action.
authors.affiliation: Department of Cardiovascular Pharmacology, Janssen Research Foundation,Beerse, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Van de Water
authors.forename: J
authors.initials: J
authors.lastname: Verheyen
authors.forename: R
authors.initials: R
authors.lastname: Xhonneux
authors.forename: R S
authors.initials: RS
authors.lastname: Reneman
mesh_terms: D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D012601:Scopolamine / Q000494:pharmacology; D013015:Sotalol / Q000494:pharmacology
chemical_list: D013015:Sotalol; D012601:Scopolamine; D000638:Amiodarone