[Cryotherapy of rectal cancer. Immunologic results].
On the basis of experimental studies carried out in animals several authors could demonstrate that cryotherapy is able to induce a raise of auto- and tumour-antibodies. The specificity of these reactions has been proved. Comparative analysis could verify greater immune response after 'in situ-destruction' of tumours than after conventional surgical excision. In 13 patients cryosurgically treated for inoperable rectal carcinoma a raised concentration of IgG and IgA could be shown in several patients in the area surrounding the carcinomatous cells by means of a direct immune fluorescent technique in biopsies of the tumour. Immune globulines of the class IgA seemed to be important. Our results suggest a probable correlation of immune response and clinical course. The prognostic value of our method has to be examined in a larger group of patients and laboratory experiments. Cryotherapy can be regarded as one of several possible forms of treatment to brake the barrier of immunity in cancer patients.
Kogel
H
H
Grundmann
R
R
Fohlmeister
I
I
Pichlmaier
H
H
D000230:Adenocarcinoma / Q000276:immunology / Q000601:surgery*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D003452:Cryosurgery; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D010166:Palliative Care; D011379:Prognosis; D012004:Rectal Neoplasms / Q000276:immunology / Q000601:surgery*; D012007:Rectum / Q000276:immunology
D000912:Antibodies, Neoplasm; D007070:Immunoglobulin A; D007074:Immunoglobulin G
Zur Kryotherapie des Rektumkarzinoms. Immunologische Ergebnisse.