title: Whole-cell currents in olfactory receptor cells of Xenopus laevis.
abstract: Olfactory mucosae of Xenopus laevis were dissociated without enzymatic treatment and the isolated olfactory neurones were studied with the tight-seal whole-cell recording configuration of the patch clamp technique. In the voltage clamp, five current components could be distinguished: a fast, TTX-sensitive Na+-current, a small and slow inward current carried by Ca2+ ions, a Ca2+-dependent K+-current, a K+-current which activates rapidly at voltages more positive than -20 mV and quickly inactivates, and a slowly activating and very slowly inactivating K+-current. Some of the characteristics of the whole-cell currents herein reported contradict previous findings while others verify them, thereby allowing a tentative interpretation of their physiological role in the transduction process.
authors.affiliation: Physiologisches Institut der Universität, Göttingen, Federal Republic of Germany.
authors.forename: D
authors.initials: D
authors.lastname: Schild
mesh_terms: D000818:Animals; D002469:Cell Separation; D008564:Membrane Potentials / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D009831:Olfactory Mucosa / Q000166:cytology / Q000294:innervation*; D013779:Tetrodotoxin / Q000494:pharmacology; D014982:Xenopus laevis / Q000502:physiology*
chemical_list: D013779:Tetrodotoxin