Effects of fenoldopam on alpha-methyl-p-tyrosine-stimulated prolactin secretion in conscious rats.
Pituitary dopamine D-2 receptors participate in the regulation of prolactin (PRL) release. No dopamine D-1 receptors have so far been identified in the pituitary gland. The present study was designed to assess the effects of fenoldopam, a selective dopamine D-1 receptor agonist, on alpha-methyl-p-tyrosine-stimulated PRL release. Fenoldopam dose dependently reduced the alpha-methyl-p-tyrosine-stimulated PRL secretion. This inhibitory effect of fenoldopam was abolished after pretreatment with SCH 23390, a specific dopamine D-1 receptor antagonist, suggesting the involvement of a dopamine D-1 receptor in PRL secretion.
Schoors
D F
DF
Department of Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.
Dupont
A G
AG
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology; D018818:Fenoldopam; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D019257:Quinpirole; D051381:Rats; D011921:Rats, Inbred WKY; D019805:alpha-Methyltyrosine
D015259:Dopamine Agents; D004873:Ergolines; D008781:Methyltyrosines; D019257:Quinpirole; D019805:alpha-Methyltyrosine; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D011388:Prolactin; D018818:Fenoldopam