title: Relationship between lipid parameters and the occurrence and severity of lesions in the heart: a study on rats fed low erucic acid rapeseed oil.
abstract: Fifty-six male Wistar SPF rats were fed a diet containing low erucic acid rapeseed (LEAR) oil (15% by weight) as the only source of lipids for 18 wk. Lipid parameters (fatty acid composition and contents of lipid classes) and the occurrence and severity of focal lesions were both determined on the heart of each animal. Four groups were constituted according to the severity of cardiac lesions. Statistical analyses were applied to the data to find a relationship between the lipid parameters and the severity of heart lesions. None of the measured parameters (heart contents of neutral lipids, total phospholipids, phosphatidylcholine, phosphatidylethanolamine, diphosphatidylglycerol, sphingomyelin and fatty acid composition of each phospholipid class) appeared to be related with the grading of the lesions. Therefore, we failed to find a direct support for the assumption that heart lesions, induced by LEAR oil, are mediated by changes in the lipid and/or fatty acid composition of heart membranes. However, this hypothesis can not be discarded.
authors.affiliation: Station de recherches sur la qualité des aliments de l'homme, INRA, Dijon, France.
authors.forename: G
authors.initials: G
authors.lastname: Rocquelin
authors.forename: P
authors.initials: P
authors.lastname: Juaneda
authors.forename: P O
authors.initials: PO
authors.lastname: Astorg
authors.forename: A
authors.initials: A
authors.lastname: Grynberg
mesh_terms: D000818:Animals; D001937:Brassica; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004883:Erucic Acids / Q000008:administration & dosage / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D008055:Lipids / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000473:pathology*; D009336:Necrosis / Q000209:etiology; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012720:Severity of Illness Index
chemical_list: D004042:Dietary Fats, Unsaturated; D004883:Erucic Acids; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D010938:Plant Oils; C049811:erucic acid