title: H1-receptor antagonists: clinical pharmacology and therapeutics.
abstract: Each H1-receptor antagonist has unique pharmacokinetic and pharmacodynamic properties, and each H1-antagonist has unique potency and potential for causing adverse effects. Some of the first-generation H1-receptor antagonists should no longer be used because their relative lack of efficacy is combined with a high potential for causing adverse effects. Some of the new H1-receptor antagonists, in manufacturers' recommended doses, seldom cause sedation but may have only modest potency. The choice of optimal H1-receptor antagonist treatment for each patient should be based on up-to-date clinical pharmacology information.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
authors.forename: F E
authors.initials: FE
authors.lastname: Simons
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D062787:Drug Overdose; D004361:Drug Tolerance; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007700:Kinetics; D011247:Pregnancy; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D006634:Histamine H1 Antagonists