Effects of stereoselective 5-HT1A agonists on male rat sexual behavior.
The effects on male rat sexual behavior of some new stereoselective 5-HT agonists, related to 8-OH-DPAT, are presented. It was found that (+)cis-8-hydroxy-1-methyl-2-(di-n-propylamino) tetralin (8-OH-MeDPAT), as well as (-)trans-2-(2-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine (2-OH-DCPA), and its 3-hydroxy-phenyl analog (3-OH-DCPA), stereoselectively facilitated the male rat sexual behavior, as evidenced by a decrease in the number of intromissions preceding ejaculation, and a shortening of the ejaculation latency. For the former two compounds, studied in further detail, the potency and efficacy appear to be of the same magnitude as previously found for 8-OH-DPAT. The results demonstrate specific 5-HT receptor involvement in the mediation of male rat sexual behavior.
Ahlenius
S
S
Department of Neuropharmacology, Astra Research Centre, Södertälje, Sweden.
Larsson
K
K
Arvidsson
L E
LE
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives*; D000818:Animals; D003521:Cyclopropanes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D003521:Cyclopropanes; D009281:Naphthalenes; D010636:Phenols; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; C054003:8-hydroxy-1-methyl-2-(di-n-propylamino)tetralin; C061811:2-(4-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine; C061809:2-(2-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine; C061810:2-(3-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin