Heterogeneity of chicken growth hormone (cGH). Identification of lipolytic and non-lipolytic variants.
The identification and biological activity of chicken growth hormone (cGH) charge variants is described. On the basis of electrophoresis and immunoreactivity chicken pituitary glands contain at least two "charge" variants (Rf = 0.22 and 0.3) which have different net charge but similar molecular weight (26,300 d). Both are immunoreactive but show different bioactivity with adipose explants, band 0.22 being lipolytic whereas band 0.3 appears to be inactive. The abundance of these cGH bands vary with age, both being higher in young birds and lower in adults. These results suggest that cGH variants may have different biological actions.
Aramburo
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C
Dept. of Physiology, Universidad Nacional Autonoma de Mexico, Mexico, D.F.
Campbell
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RM
Scanes
C G
CG
D000375:Aging / Q000378:metabolism; D000818:Animals; D002645:Chickens; D004591:Electrophoresis, Polyacrylamide Gel; D013006:Growth Hormone / Q000378:metabolism*; D008066:Lipolysis; D010902:Pituitary Gland / Q000378:metabolism; D011863:Radioimmunoassay
D013006:Growth Hormone