title: [Patterns in the antigen-nonspecific modulation of the B-cell activity in mice under the influence of a purified staphylococcal anatoxin].
abstract: Purified staphylococcal toxoid (PST) has been shown to be an antigen-nonspecific immunomodulator, capable of inducing changes in the immune response of B-cells to unrelated antigens, such as sheep red blood cells (SRBC), in a wide range of doses (from 15 to 0.15 binding units per mouse). The manifestation of the immunomodulating effect depends on the conditions of the experiment: the doses of PST and SRBC, the age of mice, the sequence of the injections of the antigens and the intervals between the injections. The simultaneous injection of PST and SRBC induces, as a rule, an increase in immune response to the test antigen, while their separate injection induces mainly immunosuppression.
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: A K
authors.initials: AK
authors.lastname: Akatov
mesh_terms: D000276:Adjuvants, Immunologic; D000375:Aging / Q000276:immunology; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013208:Staphylococcal Toxoid / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D013208:Staphylococcal Toxoid
vernacular_title: Zakonomernosti antigennespetsificheskoĭ moduliatsii aktivnosti B-kletok mysheĭ pod vliianiem ochishchennogo stafilokokkovogo anatoksina.