The effect of bilayer order and fluidity on detergent-induced liposome fusion.
Surfactants induce fusion (or increase in size) of sonicated liposomes. This phenomenon is enhanced by cholesterol and inhibited by the intrinsic polypeptide gramicidin A. By comparison with previous physical studies we conclude that liposome 'fusion' is facilitated when both fluidity and static order of the bilayer are high.
Saez
R
R
Goñi
F M
FM
Alonso
A
A
D002784:Cholesterol / Q000494:pharmacology; D004134:Dimyristoylphosphatidylcholine; D006096:Gramicidin / Q000494:pharmacology; D008051:Lipid Bilayers; D008081:Liposomes; D008560:Membrane Fluidity; D008561:Membrane Fusion / Q000187:drug effects*; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology*
D008051:Lipid Bilayers; D008081:Liposomes; D006096:Gramicidin; D011092:Polyethylene Glycols; D017830:Octoxynol; D002784:Cholesterol; D004134:Dimyristoylphosphatidylcholine