Induction and recovery characteristics of propofol, thiopental and etomidate.
Propofol, thiopental and etomidate, with 20 patients in each group, were compared for anesthesia of short duration in women undergoing termination of pregnancy, with respect to: 1: pain on injection (equally often after propofol and etomidate, but more rarely after thiopental); 2: apnea following induction (no difference); 3: involuntary muscular movements more frequent after etomidate); 4: blood pressure (larger drop after propofol); 5: heart rate (greater increase after thiopental); 6: time to eye opening on command (longer after propofol); 7: Steward score on eye opening (no difference); 8: coin counting after 15, 30 and 60 min (performance better after propofol at 15 and 30 min, producing even shorter times than preoperatively at 60 min); 9: reaction time after 15, 30 and 60 min (performance better after propofol, producing even shorter times than preoperatively at 60 min. It is concluded that the faster recovery gives propofol an advantage over thiopental and etomidate in outpatient anesthesia.
Boysen
K
K
Department of Anesthesia, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Sanchez
R
R
Krintel
J J
JJ
Hansen
M
M
Haar
P M
PM
Dyrberg
V
V
D000028:Abortion, Induced; D000328:Adult; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005045:Etomidate / Q000008:administration & dosage / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D011184:Postoperative Period; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D011597:Psychomotor Performance; D011897:Random Allocation; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D013874:Thiopental; D015742:Propofol; D005045:Etomidate