[The implementation of a strategy for the primary prevention of diabetes mellitus].
A pyruvate test for glucose tolerance was used during prophylactic medical examination of 47 students and 27 children without risk factors, 54 students with risk factors, 31 patients with type I diabetes mellitus and 220 construction workers in order to test a new methodological basis for the strategy of primary prevention of diabetes mellitus. The investigations showed the presence in a general population of 3-modal distribution of a variant of the capillary blood pyruvate level on the 120th min. of a GTT according to physiological glucose tolerance, potential (prediabetic) and actual (diabetic) carbohydrate metabolic derangements. A high informative value of the pyruvate test for glucose tolerance makes this method appropriate for identification of persons, genetically predisposed to the development of diabetes mellitus, for implementation of a population strategy of prevention of this disease as well as strategy of prevention of diabetes among persons with risk factors.
Tomashevskiĭ
Ia I
IaI
Tomashevskaia
A Ia
AIa
Ershova
T A
TA
Ho
K S
KS
Nesterovich
M R
MR
D000293:Adolescent; D000328:Adult; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood / Q000517:prevention & control*; D005951:Glucose Tolerance Test; D006801:Humans; D011322:Primary Prevention / Q000379:methods*; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D012307:Risk Factors; D013997:Time Factors; D014586:USSR
D011773:Pyruvates; D019289:Pyruvic Acid
K realizatsii strategii pervichnoĭ profilaktiki sakharnogo diabeta.