Clinical chronopharmacology of oral nitrates.
The clinical-chronopharmacological investigations with oral nitrates (ISDN, IS-5-MN) demonstrate that the drugs' pharmacokinetics and/or hemodynamic effects are circadian phase-dependent. For both an immediate-release and a sustained-release preparation of IS-5-MN peak drug concentrations coincided with peak drug effects after morning but not after evening drug application. Results indicate a circadian phase-dependency in the dose-response relationship of oral nitrates.
Lemmer
B
B
Zentrum der Pharmakologie, J. W. Goethe-Universität Frankfurt.
Scheidel
B
B
Stenzhorn
G
G
Blume
H
H
Lenhard
G
G
Grether
D
D
Renczes
J
J
Becker
H J
HJ
D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D003692:Delayed-Action Preparations; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000493:pharmacokinetics* / Q000494:pharmacology
D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate