In vivo and in vitro effects of the antifungal agent miconazole on estrogen biosynthesis in human breast cancer.
This study was undertaken to investigate whether miconazole (MCZ), an antifungal agent, inhibits aromatase activity in human breast cancer tissue preparations (n = 6). Aromatase activity in breast cancer tissue was significantly suppressed by an addition of MCZ (1 microM). The aromatase inhibition rate of MCZ was in the range 15-58%. The change of androgen and estrogen levels was also examined in peripheral blood after administering MCZ (200 mg) intravenously to four patients both with breast cancer and two with systemic fungal infection. Serum androstenedione and testosterone levels fluctuated only little. However, serum estrone and estradiol levels tended to decrease after administration of MCZ. These results suggest that MCZ may be useful in the treatment of breast cancer.
Yamamoto
T
T
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Fukuoka
M
M
Yasumura
T
T
Okada
H
H
D000231:Adenocarcinoma, Papillary / Q000378:metabolism*; D000328:Adult; D000368:Aged; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000097:blood; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008825:Miconazole / Q000494:pharmacology*; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D013739:Testosterone / Q000097:blood
D047072:Aromatase Inhibitors; D004967:Estrogens; D011960:Receptors, Estrogen; D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D008825:Miconazole