Identification of fatty acid amides in human plasma.
A family of five long-chain fatty acid carboxamides has been identified and semi-quantified in human plasma by GC-MS. One saturated and four unsaturated amides were found. Luteal phase plasma from 16 women was studied, and all five of the amides were found in ten of the subjects, but none in the other six. The structure of these endogenous amides was established by comparing their GC and MS characteristics with those of the synthetic amides prepared by ammonolysis of corresponding long-chain fatty acid acyl chlorides.
Arafat
E S
ES
Science and Mathematics Division, Rust College, Holly Springs, MS 38635.
Trimble
J W
JW
Andersen
R N
RN
Dass
C
C
Desiderio
D M
DM
D000577:Amides / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
D000577:Amides; D005227:Fatty Acids