[A clinical study of prevention of stress ulcer].
The authors have studied the possibilities of preventing digestive bleedings caused by "stress ulcers" in a large number of risk-patients recovered in the Reanimation Center of St. Camillo in Rome. On 1012 patients recovered from 1985 to 1987 the authors have pointed out 69 cases of bleeding by "stress ulcer" (6.9%). The mortality was in these patients 75%. In every patient with risk factors the Authors have performed a prophylactic treatment. This treatment, achieved with randomized standards, has been performed in a group of 311 patients with ranitidine and in a second group of 170 patients with ranitidine and somatostatin joined. In the group of patients treated with ranitidine alone the incidence of digestive bleeding was of 30 patients (9.9%), in the second group treated with ranitidine and somatostatin the incidence was of 18 patients (10%). In a previous study the authors have noted an incidence of digestive bleeding by "stress ulcers" in the 16.6% of patients prophylactically treated with cimetidine and in the 8.66% in a first group of patients treated with anti-acids and in the 11.92% of a second group of patients equally treated with anti-acids. The authors point out that their results are disappointing in opposition to the good results relieved by other Authors possibly in connection with the seriousness, the number and the length of the risk factors in the patients they have treated. They believe that the results will be better when it will be possible to dispose of effective treatment able to increase the defensive powers of the gastric mucosa, seriously impaired by the stress factors.
Manieri
R
R
Pacifici
A
A
De' Medici
M
M
D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000627:therapeutic use*; D012307:Risk Factors; D013004:Somatostatin / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000150:complications*
D013004:Somatostatin; D011899:Ranitidine
Studio clinico sulla profilassi nelle ulcere "da stress".