Effects of S-596 and carteolol, new beta-adrenergic blockers, and flurbiprofen on the human eye: a fluorophotometric study.
The effects of S-596 and coarteolol, new beta-adrenergic blockers, were studied by means of the oral fluorescein method. Transfer coefficients by diffusion, kd.pa, and by flow, kfa, were estimated in a total of 11 normal young volunteers, in whom the drug was instilled in one eye and the placebo in the fellow eye. With 0.5% dl-S-596, kd.pa increased to 124 +/- 9% (mean +/- SD) and kfa decreased to 67 +/- 10% of the control eye. With 1% dl-carteolol, kd.pa increased to 121 +/- 4%, and kfa decreased to 84 +/- 11% of the control eye. Both S-596 and carteolol increased iris permeability and decreased the aqueous flow rate significantly. In a group of 13 cases, intracapsular extraction of senile cataract was carried out with postoperative routine instillations, and in another group of 7 cases, it was carried out with additional topical flurbiprofen, a new nonsteroidal anti-inflammatory drug. Flurbiprofen ophthalmic solution (0.1%) was instilled 3, 2, 1, and 0.5 h before the surgery and 4 times a day postoperatively. On the 6th postoperative day, a fluorophotometric study was carried out using oral fluorescein, and a coefficient that reflects the permeability of the blood-aqueous barrier after the cataract surgery was calculated. It was found that additional topical flurbiprofen considerably suppresses the disruption of the blood-aqueous barrier.
Araie
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Takase
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D002354:Carteolol / Q000494:pharmacology*; D005123:Eye / Q000187:drug effects*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins; D005480:Flurbiprofen / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010783:Photometry / Q000379:methods; D011412:Propanolamines / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D005452:Fluoresceins; D011412:Propanolamines; D011422:Propionates; C024523:arotinolol; D005480:Flurbiprofen; D002354:Carteolol; D019793:Fluorescein