title: Carbohydrate metabolism on high dose growth hormone therapy in children treated for leukaemia.
abstract: The effect on carbohydrate metabolism of a high dose growth hormone (GH) regimen (1.2 U/kg per week) was assessed on 24 children who had previously been treated for leukaemia. Sixteen patients received high dose GH and eight patients received a conventional dose of GH (0.6 U/kg per week). Oral glucose tolerance tests (OGTT) were performed at baseline and after 3 months of treatment with GH. For the entire group between 0 and 3 months, there was a significant increase in mean (and standard deviation) fasting plasma glucose (0.3 +/- 0.6 mmol/L), fasting insulin level (11 +/- 26 mU/L), and 2 h insulin level (20 +/- 40 mU/L). One patient, who received a conventional dose of GH, developed substantial carbohydrate intolerance. For the entire group, there was no change in response to a carbohydrate load at 3 months as measured by the area under the plasma glucose or insulin curve. There was no significant difference between conventional and high dose groups at 3 months as assessed by these parameters. This study demonstrates that a higher dose of GH may be used in these children in an attempt to improve their final height, without increased risk of carbohydrate intolerance in the short term.
authors.affiliation: Institute of Endocrinology, Children's Hospital, Camperdown, New South Wales, Australia.
authors.forename: B A
authors.initials: BA
authors.lastname: Crawford
authors.forename: C T
authors.initials: CT
authors.lastname: Cowell
authors.forename: P
authors.initials: P
authors.lastname: Greenacre
authors.forename: N J
authors.initials: NJ
authors.lastname: Howard
authors.forename: M M
authors.initials: MM
authors.lastname: Stevens
authors.forename: M
authors.initials: M
authors.lastname: Silink
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005951:Glucose Tolerance Test; D006128:Growth / Q000187:drug effects; D013006:Growth Hormone / Q000008:administration & dosage* / Q000009:adverse effects / Q000172:deficiency; D006801:Humans; D007333:Insulin Resistance; D007938:Leukemia / Q000628:therapy*; D008297:Male
chemical_list: D001786:Blood Glucose; D013006:Growth Hormone