title: Use of cyclosporin in psoriasis.
abstract: In the treatment of severe psoriasis, cyclosporin may achieve improvement or remission at low doses, but relapse usually occurs on withdrawal of treatment. An initial dose of 3 mg/kg per day is recommended. Complete remission should not be the objective, and the role of long-term maintenance cyclosporin therapy is uncertain because of potential side-effects--especially nephrotoxicity, hypertension, and a predisposition to malignancy. Guidelines are proposed for the assessment of such treatment.
authors.affiliation: Department of Dermatology, University of Amsterdam, The Netherlands.
authors.forename: J D
authors.initials: JD
authors.lastname: Bos
authors.forename: M M
authors.initials: MM
authors.lastname: Meinardi
authors.forename: T
authors.initials: T
authors.lastname: van Joost
authors.forename: F
authors.initials: F
authors.lastname: Heule
authors.forename: A V
authors.initials: AV
authors.lastname: Powles
authors.forename: L
authors.initials: L
authors.lastname: Fry
mesh_terms: D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005069:Evaluation Studies as Topic; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D012008:Recurrence; D013997:Time Factors
chemical_list: D003524:Cyclosporins