Altered ornithine metabolism in tumor-bearing mice.
A flux of ornithine from the host tissues to the tumor was deduced from the concentrations of ornithine in plasma, ascitic liquid, liver and tumor cells during tumor growth. The activities of arginase and ornithine decarboxylase in both liver and tumor cells confirmed this proposed ornithine supply. Moreover, "in vitro" incubations of tumor cells showed that glutamine could be an additional source of ornithine for tumors. Finally, shortly before death, when tumor cell proliferation had ceased, altered hepatic ornithine metabolism was also detected.
Márquez
J
J
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Spain.
Matés
J M
JM
Quesada
A R
AR
Medina
M A
MA
Núñez de Castro
I
I
Sánchez-Jiménez
F
F
D000818:Animals; D001119:Arginase / Q000032:analysis; D001120:Arginine / Q000032:analysis; D001202:Ascitic Fluid / Q000032:analysis; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000032:analysis / Q000201:enzymology; D051379:Mice; D009368:Neoplasm Transplantation; D009952:Ornithine / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D009955:Ornithine Decarboxylase / Q000032:analysis; D014508:Urea / Q000032:analysis
D014508:Urea; D001120:Arginine; D009952:Ornithine; D001119:Arginase; D009955:Ornithine Decarboxylase