[The immunomodulating action of microwaves in the induction of an immune response to Vi antigen].
In this work the possibility of using microwaves for immunomodulation in the immunization of animals with thymus-independent antigen was studied. The projection zones of the thymus and adrenal glands of the test animals were subjected to the action of decimeter, or ultrahigh frequency (UHF), waves, while the corresponding zones of the control animals were subjected to imitation UHF irradiation. Vi-antigen was shown to be a thymus-independent antigen for rabbits (according to the results of the evaluation of the functional state of thymocytes, as manifested by the adsorption of acridine orange by the chromatin of thymocyte nuclei and by the content of RNA and DNA in the thymus). The action of UHF waves on the projection zone of the thymus was accompanied by a decrease in the glucocorticoid activity of the adrenal cortex, observed simultaneously with a pronounced immunostimulating effect. The UHF irradiation of the zone of the adrenal glands was accompanied by immunosuppression in combination with enhanced glucocorticoid activity of the adrenal cortex.
Pershin
S B
SB
Frenkel'
I D
ID
Alliluev
A P
AP
Sokolova
Z A
ZA
Bobkova
A S
AS
D000305:Adrenal Cortex Hormones / Q000097:blood / Q000528:radiation effects; D000311:Adrenal Glands / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology / Q000528:radiation effects; D000937:Antigen-Antibody Reactions / Q000528:radiation effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D007114:Immunization; D008297:Male; D008872:Microwaves; D011135:Polysaccharides, Bacterial; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D013961:Thyroid Gland / Q000378:metabolism / Q000528:radiation effects; D013963:Thyroid Hormones / Q000097:blood / Q000528:radiation effects; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000942:Antigens, Bacterial; D011135:Polysaccharides, Bacterial; D013963:Thyroid Hormones
Immunomoduliruiushchee deĭstvie mikrovoln pri induktsii immunnogo otveta na Vi-antigen.