[Physiological proteinuria in the newborn].
The levels of the individual proteins albumin, caeruloplasmin, immunoglobulin G, and alpha 2-macroglobulin were determined by Laurell's electroimmunoassay in the serum and urine of 127 children. Their age ranged from 29 gestational weeks to 13 years. Highest levels of the proteins in the urine were found during the first days of life. The values did not depend on gestational age. The urine concentrations are influenced by glomerular filtration and the reabsorption of proteins and water. The steady state of these functions can be characterized by the serum/urine concentration ratios and the clearance of the proteins. In the first days after birth the permeability of the renal barrier is maximal, the concentration ratios are low and increase markedly up to the end of the first three months; after that, they continue to rise only slightly. The clearances of all the examined individual proteins decrease between term and the third month of life, thereafter increasing until late childhood. The selectivity of the glomerular filtration also shows its highest rate of development during the first days after term.
Statz
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Statz
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Felgenhauer
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D000293:Adolescent; D000419:Albuminuria / Q000175:diagnosis; D002570:Ceruloplasmin / Q000652:urine; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007223:Infant; D007231:Infant, Newborn; D007671:Kidney Concentrating Ability; D008657:Metabolic Clearance Rate; D011507:Proteinuria / Q000175:diagnosis*; D012709:Serum Albumin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000652:urine
D007074:Immunoglobulin G; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D002570:Ceruloplasmin
Physiologische Proteinurie bei Neugeborenen.