Chronic treatment with ACTH1-24 does not produce permanent damage to the developing rat brain.
Permanent effects of ACTH1-24 on the developing rat brain were investigated. Rats were injected with 20 IU/kg of ACTH1-24 daily for 4 weeks starting at two days of age. Brain weight, protein, DNA and RNA contents, contents of monoamines and their metabolites, 2',3'-cyclic nucleotide 3'-phosphohydrolase and glutamic acid decarboxylase activities were measured at 24 h and 8 weeks after the last injection. There were no significant changes in these indicators compared to saline-injected controls. These results suggest that chronic treatment with ACTH1-24 does not permanently damage the developing rat brain.
Ito
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M
Yong
V W
VW
Perry
T L
TL
Singh
V K
VK
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D000831:Animals, Newborn; D001679:Biogenic Amines / Q000032:analysis; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D001927:Brain Diseases / Q000139:chemically induced*; D003366:Cosyntropin / Q000633:toxicity*; D004247:DNA / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D009419:Nerve Tissue Proteins; D003366:Cosyntropin; D012313:RNA; D000324:Adrenocorticotropic Hormone; D004247:DNA