[Immunohistochemical absence of adrenergic neurons in the dorsal part of the solitary tract nucleus in sudden infant death].
The immunohistochemical distribution of TH and PNMT containing neuronal elements was investigated utilizing peroxidase anti-peroxidase methods in newborn control and sudden infant death syndrome (SIDS) brainstems. The TH immunoreactive neurons, within the medulla oblongata, displayed a similar distribution in both control and SIDS tissue. However, PNMT immunoreactive neurons seen in the dorsal part of the nucleus of tractus solitarius in control tissue were not observed in SIDS tissue. This alteration of adrenergic neurons in the dorsal part of NTS (region reported to be implicated in the control of blood pressure and respiration) could explain the cardiorespiratory disorders in SIDS.
Chigr
F
F
Laboratoire d'Anatomie pathologique, Faculté de Médecine Alexis-Carrel, Lyon.
Najimi
M
M
Jordan
D
D
Denoroy
L
L
Pearson
J
J
Tommasi
M
M
Gilly
R
R
Kopp
N
N
D004837:Epinephrine / Q000502:physiology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis; D013398:Sudden Infant Death / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase; D004837:Epinephrine
Absence immunohistochimique de neurones adrénergiques dans la partie dorsale du noyau du faisceau solitaire dans la mort subite inexpliquée du nourrisson.