title: Severe clinical manifestations of primary HIV infection.
abstract: Three cases of oesophageal candidiasis in association with primary HIV infection are described. In each case the candidiasis was associated with a decreased number of circulating CD4+ cells and responded well to treatment with ketoconazole. Clinicians should be aware that severe opportunistic infections may develop during this stage of infection, presumably as a result of transient immunodeficiency. We argue that the definition of primary HIV infection should be extended to include severe opportunistic infections and neurologic presentations.
authors.affiliation: NHMRC Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Tindall
authors.forename: M
authors.initials: M
authors.lastname: Hing
authors.forename: P
authors.initials: P
authors.lastname: Edwards
authors.forename: T
authors.initials: T
authors.lastname: Barnes
authors.forename: A
authors.initials: A
authors.lastname: Mackie
authors.forename: D A
authors.initials: DA
authors.lastname: Cooper
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy; D004935:Esophageal Diseases / Q000150:complications* / Q000188:drug therapy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy
chemical_list: D007654:Ketoconazole