title: Synthesis and pharmacological properties of new derivatives of 1-diphenylacetamide-2-butanol.
abstract: Newly synthesized derivatives of 1-diphenylacetamide-2-butanol were investigated pharmacologically for their central properties in mice and rats. The most active were 2 compounds: racemic (RS) and enantiomer S (+) form of N-diphenylacetamide-2-butanol which produced hypothermia in normothermic mice, showed anxiolytic action in the four-plate test and reversed reserpine-induced hypothermia.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin.
authors.forename: K
authors.initials: K
authors.lastname: Kolasa
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: T
authors.initials: T
authors.lastname: Pietrasiewicz
authors.forename: G
authors.initials: G
authors.lastname: Czechowska
authors.forename: A
authors.initials: A
authors.lastname: Zejc
authors.forename: L
authors.initials: L
authors.lastname: Gajewczyk
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000081:Acetamides; D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D011619:Psychotropic Drugs; C065122:1-(N-diphenylacetamido)-2-butanol; C065123:1-(N-di-(4'-chlorophenyl)acetamido)-2-butanol