Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid arthritis.
We describe 2 patients who developed reversible decompensated liver disease while taking pulse dosed methotrexate (MTX) for rheumatoid arthritis. One of the patients was available for biopsy and had chronic active hepatitis--a lesion not previously described with MTX. This appears to be a unique and unusual manifestation of MTX hepatotoxicity.
Clegg
D O
DO
Department of Medicine, University of Utah, School of Medicine, Salt Lake City.
Furst
D E
DE
Tolman
K G
KG
Pogue
R
R
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001201:Ascites / Q000139:chemically induced; D056487:Chemical and Drug Induced Liver Injury, Chronic; D005234:Fatty Liver / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged
D008727:Methotrexate