Hormonal regulation on bioactive aortic substance (BAS) production.
Rat's vessel wall releases a protein named BAS (Bioactive Aortic Substance) whose antiaggregating effect on platelets and inotropy vascular properties have been already described. In this work we have investigated the effects of pregnancy, gonadectomy and gonadectomy with hormonal treatment on the BAS production from rat aortic rings. BAS production in pregnancy and ovariectomized rats was markedly decreased compared to normal rats. Return to normal values was obtained after estradiol treatment in ovariectomized rats. Castration resulted in an increased of BAS production which was suppressed by testosterone treatment.
Bermejo
E
E
Department of Hemostasis and Thrombosis, Instituto de Investigaciones Hematologicas Mariano R. Castex, Buenos Aires, Argentina.
Maugeri
N
N
Chaud
M
M
Gimeno
M
M
Lazzari
M A
MA
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D013739:Testosterone; D004958:Estradiol