Stimulation of tyrosinase by dihydroxy phenyl derivatives.
Isoprenaline (0.3 mM) moderately increased the tyrosinase activity of cultured human melanoma cells, while another beta-adrenoceptor agonist, terbutaline (1-3 mM) and a catechol compound, dopac (0.1-0.3 mM) induced a several fold increase in the enzyme activity. Isoprenaline (0.3-1 mM) and dopac (0.3-1 mM) also exerted pronounced toxic effects on the cells. The data suggest: 1) a possible role for beta-adrenoceptors in the regulation of human melanogenesis; 2) two different ways of action for isoprenaline in inducing tyrosinase elevation; 3) the possible usefulness of dopac as a chemotherapeutic agent.
Karg
E
E
Department of Dermatology, University of Lund, Sweden.
Rosengren
E
E
Rorsman
H
H
D015102:3,4-Dihydroxyphenylacetic Acid / Q000494:pharmacology*; D004156:Catechol Oxidase / Q000378:metabolism*; D002460:Cell Line; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008545:Melanoma / Q000201:enzymology*; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D010648:Phenylacetates / Q000494:pharmacology*; D013726:Terbutaline / Q000494:pharmacology*
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; D007545:Isoproterenol; D013726:Terbutaline