title: Interzeta-globin gene hypervariable regions in Chinese: application to genetic diagnosis of adult polycystic kidney disease.
abstract: In order to investigate the interzeta-globin gene hypervariable regions (IZHVR) in Chinese, DNA samples from 114 unrelated normal individuals were analyzed using the restriction endonuclease BglII and hybridized with a 32P-labeled zeta-globin probe. Four polymorphic fragments containing IZHVR with different frequencies were found: 11.3 kb, 0.24; 10.8 kb, 0.50; 10.4 kb, 0.05, and 10.0 kb, 0.21. Using these polymorphic fragments as linkage markers, we were able to trace the affected siblings in a three-generation Chinese family with a history of adult polycystic kidney disease.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Wann
authors.forename: T W
authors.initials: TW
authors.lastname: Chen
authors.forename: T P
authors.initials: TP
authors.lastname: Huang
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: H W
authors.initials: HW
authors.lastname: Peng
mesh_terms: D002681:China; D005260:Female; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006801:Humans; D008297:Male; D007690:Polycystic Kidney Diseases / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005914:Globins