[Localization of embryonic prealbumin-1 in the tissues of human malignant tumors].
The distribution of human embryonic prealbumin-1 (EPA-1) has been studied in 52 different malignant tumours using indirect immunofluorescent technique and two types of antibodies to different antigenic determinants: "EPA-1" and "EPA-1S". In mesenchymal tumours (except for desmoids and chondrosarcomas) this glycoproteid was observed in the cytoplasm of tumour cells, but "EPA-1S"--in the connective-tissue fibers only. Localization of glycoproteid EPA-1 depends on the type of the used primary antibodies. EPA-1 is also observed in the connective-tissue stroma of most of epithelial tumours. A conclusion is made that transformation of EPA-1 glycoproteid synthesis from definitive to fetal form occurs in malignant tumours.
Vasil'ev
M Iu
MIu
Sergeeva
N S
NS
Avdeev
G I
GI
D000818:Animals; D000918:Antibody Specificity; D000939:Epitopes / Q000032:analysis; D005326:Fetal Proteins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007114:Immunization; D009363:Neoplasm Proteins / Q000032:analysis*; D009369:Neoplasms / Q000032:analysis*; D011228:Prealbumin; D011817:Rabbits
D000939:Epitopes; D005326:Fetal Proteins; D006023:Glycoproteins; D009363:Neoplasm Proteins; D011228:Prealbumin; C031458:embryonic prealbumin
Izuchenie lokalizatsii émbrional'nogo preal'bumina-l v tkaniakh zlokachestvennykh opukholeĭ cheloveka.