Modulation of synaptic transmission in the rabbit coeliac ganglia by gastric and duodenal mechanoreceptors.
The involvement of duodenal and gastric mechanoreceptors in the modulation of synaptic transmission was investigated in a rabbit sympathetic prevertebral ganglion. The present study was performed in vitro on the coeliac plexus connected to the stomach and the duodenum. The electrical activity of ganglionic neurons was recorded using intracellular recording techniques. The patterns of synaptic activation of these ganglionic neurons in response to the activation of mechanoreceptors by gastric or duodenal distension were investigated. Although gastric or duodenal distension was unable to elicit any fast synaptic activity in ganglionic neurons, it produced either an inhibition or a facilitation of the fast nicotinic excitatory postsynaptic potentials elicited by stimulation of the thoracic splanchnic nerves. In addition, this distension triggered long-lasting (3-11 min) modifications in the electrical properties of the ganglionic neurons, i.e. slow depolarizations (6-18 mV) or slow hyperpolarizations (3-6 mV), which were sometimes associated with a decrease in the input membrane resistance. After cooling of the nerves connecting the coeliac ganglia to the stomach, the activation of gastric or duodenal mechanoreceptors was no longer able to modify the fast synaptic activation or the electrical properties of the ganglionic neurons. The results demonstrate that gastric and duodenal mechanoreceptors project onto neurons of the coeliac ganglia and change their excitability as well as the central inputs they receive. The long duration of these modifications suggests that gastric and duodenal mechanoreceptors can modulate the activity of the neurons of the coeliac ganglia.
Mazet
B
B
Département de Physiologie et Neurophysiologie, URA CNRS 205, Faculté des Sciences et Techniques, Marseille, France.
Miolan
J P
JP
Niel
J P
JP
Julé
Y
Y
Roman
C
C
D000200:Action Potentials; D000818:Animals; D003080:Cold Temperature; D004386:Duodenum / Q000294:innervation*; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D010812:Physical Stimulation; D011817:Rabbits; D013270:Stomach / Q000294:innervation*