title: Hb Fontainebleau [alpha 21(B2)Ala----pro], a new silent mutant hemoglobin.
abstract: Hb Fontainebleau [alpha 21(B2)Ala----Pro] was found in a family of Italian origin. This new variant has electrophoretic properties identical to those of Hb A with the exception of isoelectrofocusing in which it migrates like Hb A1c. The introduction of a prolyl residue at the beginning of the B helix in the alpha chain does not lead to a change in the stability or oxygen binding properties of the hemoglobin molecule.
authors.affiliation: INSERM U299, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: H
authors.initials: H
authors.lastname: Wajcman
authors.forename: Y
authors.initials: Y
authors.lastname: Blouquit
authors.forename: G
authors.initials: G
authors.lastname: Gombaud-Saintonge
authors.forename: J
authors.initials: J
authors.lastname: Riou
authors.forename: F
authors.initials: F
authors.lastname: Galacteros
mesh_terms: D000293:Adolescent; D000409:Alanine; D000595:Amino Acid Sequence; D005260:Female; D014644:Genetic Variation; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D010375:Pedigree; D011392:Proline
chemical_list: D006455:Hemoglobins, Abnormal; C062066:hemoglobin Fontainebleau; D011392:Proline; D000409:Alanine