A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.
1. The ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops was compared in nine healthy human volunteers, using non-contact tonometry. 2. Considering all post-dosing measurements compared with placebo and including the baseline values as continuous independent variables, using multiple linear regression analysis, both bromocriptine and timolol had a significant ocular hypotensive effect (P less than 0.0001) in the treated eye with a significant but lesser effect in the contralateral eye. 3. In the concentrations used, timolol was more efficacious than bromocriptine in lowering intraocular pressure (P less than 0.025). 4. Using other forms of vehicles for bromocriptine to improve efficacy and studying the ocular hypotensive effect of topical application of other dopamine-2-receptor agonists such as pergolide and lisuride was suggested.
al-Sereiti
M R
MR
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
Coakes
R L
RL
O'Sullivan
D P
DP
Turner
P
P
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D009883:Ophthalmic Solutions; D001971:Bromocriptine; D013999:Timolol