Lymphoma and hypercalcemia in a pediatric orthotopic liver transplant patient.
We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vitamin D state, suggesting that it has a role in the pathophysiology of this B cell lymphoma hypercalcemia. The clinical course and management of this disorder with a 31-month follow-up are described.
Nakazato
P
P
Transplant Service, San Francisco, CA 94120.
Esquivel
C O
CO
Urbach
A H
AH
Makowka
L
L
Scantlebury
V
V
Jaffe
R
R
Starzl
T E
TE
D002117:Calcitriol / Q000097:blood; D002675:Child, Preschool; D006084:Graft Rejection; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008223:Lymphoma / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*
D002117:Calcitriol