Effect of oleic acid on diffusion of drugs through hairless mouse skin.
The effect of oleic acid in propylene glycol or 2-ethyl-1,3-hexanediol vehicle systems on the skin permeability of 17 beta-estradiol, triamcinolone acetonide and trifluorothymidine was studied in vitro. The largest enhancement was obtained from a vehicle containing oleic acid in propylene glycol and the enhancement increased with increasing aqueous solubility of the drug. Oleic acid gave far less enhancement when propylene glycol was replaced by 2-ethyl-1,3-hexanediol.
Loftsson
T
T
Gildersleeve
N
N
Soliman
R
R
Bodor
N
N
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D004058:Diffusion; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D008815:Mice, Inbred Strains; D009829:Oleic Acids / Q000494:pharmacology*; D012869:Skin Absorption / Q000187:drug effects*
D001381:Azepines; D009829:Oleic Acids; C035229:laurocapram