Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.
Treatment of chronic ground squirrel hepatitis virus infection with arabinosyladenine monophosphate at 20 mg/kg per day for 3 weeks caused marked decreases in serum virion-associated DNA polymerase concentrations in three of five squirrels. Statistically significant but less dramatic decreases in enzymatic activity were noted in two of six squirrels treated with 50 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine per kg per day. After therapy, DNA polymerase activities rose to pretreatment levels.
Smee
D F
DF
Knight
S S
SS
Duke
A E
AE
Robinson
W S
WS
Matthews
T R
TR
Marion
P L
PL
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001088:Arabinonucleotides / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000097:blood*; D015774:Ganciclovir; D006518:Hepatitis Viruses / Q000187:drug effects* / Q000201:enzymology; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy* / Q000382:microbiology; D008099:Liver / Q000201:enzymology; D012589:Sciuridae / Q000382:microbiology*; D001084:Vidarabine Phosphate / Q000494:pharmacology* / Q000627:therapeutic use; D014771:Virion / Q000201:enzymology
D000998:Antiviral Agents; D001088:Arabinonucleotides; D001084:Vidarabine Phosphate; D004259:DNA-Directed DNA Polymerase; D015774:Ganciclovir; D000212:Acyclovir