Catecholamine levels in the brain and adrenals of rats poisoned with triphenyltin (Brestan 60).
The effects of organotin fungicide Brestan 60 and SnCl4 on rat brain and adrenal catecholamines (CA) were examined. Rats were treated with 0.5 LD50 of Brestan 60 (acute experiment) or 0.05 LD50 (subchronic experiment) and SnCl4 in equal dose of inorganic tin. Brestan 60 in both experiments decreased CA concentrations in the brain and adrenals. In contrast, SnCl4 did not alter brain CA but had greater effect on adrenal CA than Brestan 60 had. Effects of organotin fungicide may be related with inhibition of oxidative phosphorylation and membrane-bound ATP-ases.
Zieliński
W
W
Department of Toxicology, Warsaw Medical School, Poland.
Brzeziński
J
J
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009947:Organotin Compounds / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D009947:Organotin Compounds; C030665:triphenyltin; D004298:Dopamine; D009638:Norepinephrine