[Value of SLX and CA19-9 in the serum and tissue in colorectal cancer including the relation to Lewis blood type].
This study was undertaken to determine the value of SLX and CA19-9 in the tissue and serum in colorectal cancer and adenoma including the relation to Lewis blood type. SLX isolated by Hakomori et al is one of sialyl SSEA-1 antigens characterized by type 2 chain lacto series glycolipids. Distribution of SLX and CA19-9 was determined in 137 specimens of colorectal cancer (107 advanced and 30 early cancer) and 20 specimens of adenoma by using immunoperoxidase (ABC) method. Serum SLX, CA19-9 and CEA levels were measured preoperatively in 58 cases with histologically proven colorectal cancer by using RIA kits. Simultaneously, Lewis blood type were determined by hemagglutination test in 31 cases. The following results were obtained; 1) SLX and CA19-9 were mostly observed in apical membrane and luminal contents, but a few in cytoplasma of cancer tissue. Positive rate of SLX and CA19-9 was 96.2% and 88.8%, respectively. 2) SLX and CA19-9 were lightly stained in the goblet cells and surface epithelium in some of the mucosa adjacent to the cancer tissue, and positive rate of SLX and CA19-9 was 24.3% and 32.7%, respectively. 3) Positive rate of SLX and CA19-9 was 60% and 50% in adenoma, and 94% and 80% in "m" cancer. Positive rate was not different due to grade of dysplasia of adenoma, but distribution of SLX or grade of the staining of CA19-9 was different between adenoma with mild and moderate dysplasia.(ABSTRACT TRUNCATED AT 250 WORDS)
Igarashi
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D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology; D000236:Adenoma / Q000097:blood / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood / Q000276:immunology*; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D006017:Glycolipids; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen