title: Excitatory amino acid treatment of the ventromedial globus pallidus enhances dopamine utilization in the prefrontal cortex of the rat via the thalamic mediodorsal nucleus.
abstract: Infusion of a low dose (5 microM) of the cell-selective chemical excitant quisqualic acid (QUIS) into rostral ventromedial globus pallidus (GP) had no immediate effect on DA utilization (assessed as [DOPAC]:[DA] and [HVA]:[DA] ratios) in either the medial bank of the prefrontal cortex (FCx) or the agranular insular cortex (AgCx). In contrast, a larger dose (630 microM) of another excitant sodium ibotenate (IBO) produced an immediate bilaterally symmetrical increase in both indices of DA utilization in FCx. There was also a marked trend towards a bilateral increase in these indices of DA utilization in AgCx. In order to determine whether these effects on cortical DA utilization are mediated by a direct cortical route or via the thalamic mediodorsal nucleus (lateral division, MDL), infusions of IBO into GP were repeated in animals with a 1-week-old N-methyl-D-aspartate lesion of MDL. The increase in DA utilization of FCx following infusion of IBO into GP was abolished, although the trend towards increased DA utilization in AgCx was still maintained. Since MDL innervates FCx but not AgCx and since we have previously shown that MDL lesions alone have no effect on DA utilization in either cortical region, the present results suggest that the changes in cortical DA utilization are probably mediated via MD. Thus in addition to the well-documented control exerted by the thalamus over brain DA function, this has now been extended in the present study to include GP, which projects both directly and indirectly to the thalamus.
authors.affiliation: Department of Pharmacology, University of Bristol, U.K.
authors.forename: M W
authors.initials: MW
authors.lastname: Jones
authors.forename: I C
authors.initials: IC
authors.lastname: Kilpatrick
authors.forename: O T
authors.initials: OT
authors.lastname: Phillipson
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism*; D005917:Globus Pallidus / Q000187:drug effects / Q000502:physiology*; D007051:Ibotenic Acid / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*
chemical_list: D010080:Oxazoles; D007051:Ibotenic Acid; D004298:Dopamine