title: Ichthyosis linearis circumflexa: morphological and biochemical studies.
abstract: Extensive morphological and biochemical studies were carried out on two sibling cases of ichthyosis linearis circumflexa. The condition was found to be similar to psoriasis in the following ways: effectiveness of PUVA therapy, psoriatic changes on light and electron microscopy, high urinary polyamine levels, elevation of several enzyme activities in the scales, and a remarkable change in keratin molecules. These results may reflect an increased epidermal proliferation with a reduced epidermal transit time, as occurs in psoriasis.
authors.forename: T
authors.initials: T
authors.lastname: Yoshiike
authors.forename: M
authors.initials: M
authors.lastname: Manabe
authors.forename: M
authors.initials: M
authors.lastname: Negi
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007633:Keratins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D011073:Polyamines / Q000652:urine; D011565:Psoriasis / Q000378:metabolism; D012867:Skin / Q000201:enzymology / Q000648:ultrastructure*
chemical_list: D000596:Amino Acids; D011073:Polyamines; D007633:Keratins