Murine transfer factor. II. Transfer of delayed hypersensitivity to synthetic antigens.
Synthetic polyaminoacid antigens were used to examine the specificity of transfer of delayed-type hypersensitivity with spleen cell dialysates in mice. Dialysates from GAT10-sensitized donors sensitized recipients to GAT10, but not GLA5 or cytochrome c. Dialysates from GLA5-sensitized donors sensitized recipients to GLA5, but not GAT10 or cytochrome c. We interpret these findings as consistent with the concept that passive transfer of delayed hypersensitivity with dialyzable materials is an immunologically specific event.
Kirkpatrick
C H
CH
Rozzo
S J
SJ
Mascali
J J
JJ
Merryman
C F
CF
D000818:Animals; D003956:Dialysis; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007116:Immunization, Passive / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010455:Peptides / Q000008:administration & dosage / Q000276:immunology*; D011099:Polyglutamic Acid / Q000008:administration & dosage / Q000276:immunology* / Q000031:analogs & derivatives; D011107:Polylysine / Q000008:administration & dosage / Q000276:immunology* / Q000031:analogs & derivatives; D011108:Polymers; D013154:Spleen / Q000166:cytology; D014165:Transfer Factor / Q000276:immunology*
D010455:Peptides; D011108:Polymers; D014165:Transfer Factor; D011107:Polylysine; D011099:Polyglutamic Acid; C030391:poly(glutamic acid-lysine); C020749:GAT