Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments.
Twenty-two chemicals were tested for mutagenicity in the sex-linked recessive lethal (SLRL) mutation assay after being fed to Drosophila melanogaster larvae. One compound, maleic hydrazide, was found to be mutagenic. It was tested for the ability to produce reciprocal translocations (RTs) and was positive in that assay as well.
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Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912.
Mason
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Valencia
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D000818:Animals; D004330:Drosophila / Q000187:drug effects* / Q000235:genetics; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D005804:Genes, Lethal; D005808:Genes, Recessive; D007814:Larva / Q000187:drug effects / Q000235:genetics; D015394:Molecular Structure; D005810:Multigene Family; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012730:Sex Chromosomes; D014178:Translocation, Genetic
D004785:Environmental Pollutants; D009153:Mutagens