Simultaneous study of the pharmacokinetics of intravenous and oral nicardipine using a stable isotope.
The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled nicardipine (D0 nicardipine) was also given. The study was carried out in six healthy male volunteers, aged between 24 and 27 years, according to a Latin square cross-over design. Similar values were found for each kinetic parameter after i.v. administration regardless of whether it was administered alone by that route or with an oral dose. The plasma level-time curves of nicardipine were described by a three open compartment model. The total plasma clearance was about 800 ml/min, the volume of distribution was of the order of 1 l/kg and the half-life of beta-elimination ranged from 4 to 5 h. The elimination rate constant beta was independent of the route of administration.
Guerret
M
M
Centre de Recherche Pharmaceutique, Laboratories Sandoz, Rueil-Malmaison, Paris, France.
Cheymol
G
G
Hubert
M
M
Julien-Larose
C
C
Lavene
D
D
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009529:Nicardipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011897:Random Allocation
D009529:Nicardipine