The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity.
Intravenous injection of platelet activating factor (PAF) in anesthetized guinea pigs induces non-selective airway hyperreactivity. This response to PAF was reduced in a dose-dependent manner by systemic administration of established prophylactic anti-asthma drugs (ketotifen, cromoglycate, aminophylline and glucocorticosteroids) and by competitive antagonists of PAF. These inhibitory effects could not be accounted for by antagonism of histamine (H1), serotonin or peptidoleukotrienes receptors; parasympatholytic activity; cyclo-oxygenase or lipoxygenase inhibition; mast cell stabilization; or bronchodilatation. Infusion or injection of PAF to induce airway hyperreactivity in the guinea pig may provide a prospective test for prophylactic anti-asthma drugs.
Sanjar
S
S
Preclinical Research, Sandoz AG, Basel, Switzerland.
Smith
D
D
Schaeublin
E
E
Kristersson
A
A
Chapman
I
I
Mazzoni
L
L
Morley
J
J
D000818:Animals; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control*; D016861:Cyclooxygenase Inhibitors; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D016859:Lipoxygenase Inhibitors; D008168:Lung / Q000187:drug effects / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D010972:Platelet Activating Factor / Q000494:pharmacology*; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D006634:Histamine H1 Antagonists; D016859:Lipoxygenase Inhibitors; D010972:Platelet Activating Factor; D012702:Serotonin Antagonists