title: Influence of CDP-choline administration on the aortic wall lesions in dietically hypercholesterolaemic rabbits: a morphometric evaluation.
abstract: In New Zealand rabbits subjected for a 2 month period to a 1% or 2% hypercholesterolic diet, larger intimal involvement and histologically heavier lesions were observed in the animals on a hypercholesterolic diet. The intimal involvement was larger in the aortic arch. In groups of rabbits simultaneously subjected to similar diets and to i.v. CDP-choline injections, the intimal involvement appeared reduced (p less than 0.01) both in the arch and in the descending tract of the thoracic aorta.
authors.affiliation: Centre for Research on Arteriosclerosis, University of Siena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Auteri
authors.forename: G
authors.initials: G
authors.lastname: Bianciardi
authors.forename: P
authors.initials: P
authors.lastname: Fabrini
authors.forename: L
authors.initials: L
authors.lastname: Resi
authors.forename: M
authors.initials: M
authors.lastname: Salvi
authors.forename: P
authors.initials: P
authors.lastname: Toti
authors.forename: P
authors.initials: P
authors.lastname: Tanganelli
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004032:Diet; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000150:complications*; D011817:Rabbits; D014652:Vascular Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D002791:Cholesterol, Dietary; D003566:Cytidine Diphosphate Choline; D002784:Cholesterol; D002794:Choline