Hemolysis following platelet transfusions from ABO-incompatible donors.
Two hemolytic transfusion reactions related to isoagglutinins present in group O platelet concentrates are reported. The first, a severe reaction in a group A 10-kg patient, resulted from transfusion of 200 ml of plasma containing a hemolytic anti-A, titer 16, and an IgG anti-A, titer of 32,000. In the second case, a group B adult received between 50 and 70 ml of O plasma with a titer (16,000) of anti-B. This was followed by hemolysis of approximately 40 percent of the patient's red cell volume.
Pierce
R N
RN
Reich
L M
LM
Mayer
K
K
D000017:ABO Blood-Group System / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000209:etiology*; D002675:Child, Preschool; D000939:Epitopes; D005260:Female; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000008:administration & dosage; D008875:Middle Aged; D010949:Plasma / Q000276:immunology; D017713:Platelet Transfusion; D065227:Transfusion Reaction
D000017:ABO Blood-Group System; D000939:Epitopes; D007518:Isoantibodies