[The effect of oxytocin and sigetin on Ca2+ transport in the fraction of plasma membranes of myometrial cells].
Oxytocin and sigetin were studied for their effect on the active and passive transport of Ca2+ in the fraction of myometrium sarcolemma in women. Oxytocin (5.10(-7) M) introduced into the sarcolemma vesicles and sigetin (5.10(-3) M) added into the incubation medium inhibit Mg2+, ATP-dependent accumulation of Ca2+ in these structures. The both agents in the mentioned concentration do not affect the passive release of cation from vesicles. A conclusion is drawn that inhibition of the calcium pump of myometrium cell plasma membranes underlies the physiological action of oxytocin and sigetin as stimulators of the contractile activity of the myometrium.
Stepankovskaia
G K
GK
Shinlova
O P
OP
Fomin
V P
VP
Kosterin
S A
SA
Iarotskiĭ
N E
NE
D001557:Benzenesulfonates / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D009215:Myometrium / Q000187:drug effects* / Q000378:metabolism; D010121:Oxytocin / Q000494:pharmacology*; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism
D001557:Benzenesulfonates; D010121:Oxytocin; C001770:sigetin; D002118:Calcium
Vliianie oksitotsina i sigetina na transport Ca2+ vo fraktsii plazmaticheskikh membran kletok miometriia.