title: Hepatocyte necrosis associated with HBV marker expression and T cytotoxic cells in situ in chronic hepatitis B.
abstract: To explore the role of HBV antigen expression and monocyte infiltrate in situ in chronic hepatitis, HBV markers and compositions and number of monocytes in the liver of chronic hepatitis B were immunohistochemically located and identified, and correlated with hepatocyte necrosis. It was found that hepatic necrosis frequently took place in the centre or boundary of membranous HBsAg and/or HBcAg expression and the majority of monocytes accumulated in the necrotic areas showed CD8+ cell token in HBeAg-positive stage of chronic active hepatitis. On the other hand, with HBeAg positivity converted into HBeAg-negativity or anti-HBe-positivity, HBV antigen expression significantly declined, CD4+ cells remarkably increased as compared to HBeAg-positive status. These findings suggest that there may be distinct pathogenesis of hepatic necrosis in different stages of chronic HBV infection.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: L J
authors.initials: LJ
authors.lastname: Hao
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006509:Hepatitis B / Q000276:immunology / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006521:Hepatitis, Chronic / Q000276:immunology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D009336:Necrosis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015415:Biomarkers; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens