title: [Preliminary report on the clinical application of anti-Jo-1 antibody].
abstract: Jo-1 antigen was purified from the rabbit thymus acetone powder. Using it as antigen, we found anti-Jo-1 antibody in 25% of polymyositis, 7.1% in dermatomyositis, none in other connective tissue diseases nor non-connective tissue diseases. Other antinuclear antibodies, eg anti-RNP, anti-SSA were also found in our polymyositis-dermatomyositis patients. Our study suggested, the positivity of anti-Jo 1 antibody not only confirmed the patient's diagnosis of polymyositis but also demonstrated the autoimmune pathogenesis of this disease.
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
authors.forename: P C
authors.initials: PC
authors.lastname: Cheng
authors.forename: N C
authors.initials: NC
authors.lastname: Zhang
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis*; D003240:Connective Tissue Diseases / Q000276:immunology*; D006801:Humans; D009220:Myositis / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody