Modification of low density lipoproteins from hypertriglyceridemic patients by macrophages in vitro and the effect of bezafibrate treatment.
After 30 days of bezafibrate administration to 5 patients with hypertriglyceridaemia and hyperapobetalipoproteinaemia a rise was found in the concentrations of cholesterol and vitamin E in the LDL fraction. In consequence the susceptibility of the LDL fraction to oxidation by macrophages was reduced. The uptake of modified LDL by these cells was decreased in relation to the uptake before treatment.
Naruszewicz
M
M
National Food and Nutrition Institute, Department of Pathophysiology, Warsaw, Poland.
Mirkiewicz
E
E
Kłosiewicz-Latoszek
L
L
D000328:Adult; D001629:Bezafibrate / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000188:drug therapy* / Q000378:metabolism; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000378:metabolism
D008077:Lipoproteins, LDL; D014810:Vitamin E; D002784:Cholesterol; D001629:Bezafibrate