title: Glandular secretion of lactoferrin in a patient with neutrophil lactoferrin deficiency.
abstract: Patients with specific granule deficiency (SGD) develop recurrent severe bacterial skin infections. Neutrophils from patients with SGD are deficient in lactoferrin (Lf), an antimicrobial protein commonly found in many mucosal secretions. Unstimulated and stimulated nasal secretions, saliva, and tears were collected from a patient with SGD and from normal control subjects and were analyzed for Lf. The secretions from the patient contained normal values of Lf, suggesting that the glands secrete Lf from a source other than neutrophils. Immunohistochemical staining of normal nasal mucosa demonstrated that Lf is localized within serous submucosal gland cells and that neutrophils are not normally observed in the nasal mucosa. These findings suggest that glandular tissues produce and locally secrete Lf by processes that are independent of neutrophil degranulation.
authors.affiliation: Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
authors.forename: G D
authors.initials: GD
authors.lastname: Raphael
authors.forename: J L
authors.initials: JL
authors.lastname: Davis
authors.forename: P C
authors.initials: PC
authors.lastname: Fox
authors.forename: H L
authors.initials: HL
authors.lastname: Malech
authors.forename: J I
authors.initials: JI
authors.lastname: Gallin
authors.forename: J N
authors.initials: JN
authors.lastname: Baraniuk
authors.forename: M A
authors.initials: MA
authors.lastname: Kaliner
mesh_terms: D002648:Child; D006651:Histocytochemistry; D006801:Humans; D007781:Lactoferrin / Q000032:analysis / Q000172:deficiency / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000032:analysis; D009299:Nasal Provocation Tests; D009504:Neutrophils / Q000378:metabolism*; D012463:Saliva / Q000032:analysis; D013666:Tears / Q000032:analysis
chemical_list: D007782:Lactoglobulins; D007781:Lactoferrin