title: Increase in intracellular cysteine after exposure to dithiothreitol: implications in radiobiology.
abstract: Dithiothreitol reduces cystine in tissue-culture medium, and the resulting cysteine is accumulated in Chinese hamster V79 cells to an extent which should be taken into account in evaluating models of radiosensitivity and the effects of thiol radioprotectors.
authors.affiliation: Gray Laboratory of the Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex, U.K.
authors.forename: M F
authors.initials: MF
authors.lastname: Dennis
authors.forename: M R
authors.initials: MR
authors.lastname: Stratford
authors.forename: P
authors.initials: P
authors.lastname: Wardman
authors.forename: R R
authors.initials: RR
authors.lastname: Watfa
mesh_terms: D000818:Animals; D006224:Cricetinae; D003545:Cysteine / Q000378:metabolism*; D004229:Dithiothreitol / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D066298:In Vitro Techniques; D011836:Radiation Tolerance / Q000502:physiology*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D011837:Radiation-Protective Agents; D003545:Cysteine; D004229:Dithiothreitol