Clinical considerations and biochemical basis of prognosis of cervical spinal cord injury.
A total of 118 patients with cervical spinal cord injury were studied to determine the neurologic improvement achieved by either conservative or surgical treatment. Useful recovery was observed in 55% of the patients with incomplete cord injuries, but in none of those with complete cord injuries. There was no significant difference between the treatment groups regarding neurologic improvement. In experimental studies on rats, the increased levels of lipid peroxides and thromboxane after spinal cord injury were found to be proportional to the magnitude of injury. These evidences suggest that spinal cord injury is directly related with the magnitude of injury, and the prognosis is determined entirely at the time of injury.
Ikata
T
T
Department of Orthopedic Surgery, School of Medicine, Tokushima University, Japan.
Iwasa
K
K
Morimoto
K
K
Tonai
T
T
Taoka
Y
Y
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D000818:Animals; D005260:Female; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use; D011379:Prognosis; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000175:diagnosis* / Q000628:therapy; D013929:Thromboxane B2 / Q000378:metabolism*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D005609:Free Radicals; D008054:Lipid Peroxides; D008689:Methacrylates; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013930:Thromboxane-A Synthase; C034364:ozagrel