title: [Treatment of hypophyseal prolactin-secreting macroadenomas].
abstract: We investigated a group of 26 patients with prolactin-secreting pituitary macroadenomas. Seventeen underwent neurosurgical operation alone, nine were also submitted to medical therapy with bromocriptine 7.5 mg/day, immediately after the operation. Patients presented similar clinical and biological characteristics. Fourteen patients without medical therapy showed a persistent hyperprolactinemia and the tumor recurred in 8 of these 17 patients. Of the 9 patients receiving medical and surgical therapy, only 1 presented persistent hyperlactinemia and none relapsed. Our results suggest that combined sequential surgical and medical therapy may be useful in the management of patients with prolactin-secreting pituitary macroadenomas.
authors.forename: R
authors.initials: R
authors.lastname: Candrina
authors.forename: M
authors.initials: M
authors.lastname: Tosoni
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D015175:Prolactinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D001971:Bromocriptine
vernacular_title: La terapia dei macroadenomi ipofisari prolattino-secernenti.