title: Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum.
abstract: Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the intestine. A perfusion technique has been used to investigate the effect of nufenoxole (1 mg/kg intrajejunally) on water and solute transport stimulated by the secretagogue, dioctyl sodium sulphosuccinate, in the human jejunum in vivo. Nufenoxole reversed the direction of jejunal transport of salt and water from net secretion to net absorption. These changes in water and electrolyte transport were inhibited by intravenous naloxone, the opioid antagonist. Nufenoxole possesses potent antisecretory properties, which are mediated via opioid receptors and may contribute to its antidiarrhoeal action in man.
authors.forename: K J
authors.initials: KJ
authors.lastname: Moriarty
authors.forename: D D
authors.initials: DD
authors.lastname: Rolston
authors.forename: M J
authors.initials: MJ
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: Shield
authors.forename: M L
authors.initials: ML
authors.lastname: Clark
mesh_terms: D000328:Adult; D000930:Antidiarrheals / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001692:Biological Transport; D001834:Body Water / Q000187:drug effects / Q000378:metabolism; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D010069:Oxadiazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010477:Perfusion
chemical_list: D000930:Antidiarrheals; D004573:Electrolytes; D010069:Oxadiazoles; D004143:Dioctyl Sulfosuccinic Acid; D009270:Naloxone; C015627:nufenoxole