[Changes in the platelet-vascular system of hemostasis in patients with ischemic heart disease and hypertension after the treatment].
The status of platelet aggregability, cyclic nucleotides and the thromboxane-prostacyclin system was examined in 40 patients with Functional Class II-III angina pectoris treated with perdipine, a calcium antagonist, and in 40 patients with Stage II hypertensive disease treated with tenolol, a beta-adrenoblocker. The therapy was found to modify the initially abnormal parameters of platelet-vessel hemostasis both in coronary heart disease and hypertension. When the initial parameters of platelet functional activity were normal, the treatment with perdipine and tenolol caused no noticeable changes.
Zadionchenko
V S
VS
Kamenker
E S
ES
Chikvashvili
I A
IA
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D001262:Atenolol; D009529:Nicardipine
Izmeneniia trombotsitarno-sosudistogo zvena gemostaza u bo'lnykh ishemicheskoĭ bolez'niu serdtsa i gipertonicheskoĭ bolez'niu pod vliianiem lecheniia.