Preparation of leukocyte-poor platelet concentrates for transfusion by filtration through a new cellulose acetate filter.
The preparation of leukocyte-poor platelet concentrates using a new cellulose acetate filter was evaluated. The platelet loss was 9% when freshly prepared platelet concentrates were filtered. The platelet loss was more variable and about 16% (p less than 0.05) when 5 day old platelets were filtered. The leukocyte removal was not influenced by storage time. The mean absolute number of leukocytes was about 1 x 10(7) and 3 x 10(7) for freshly prepared or 5 day old platelet concentrates, respectively (p less than 0.05). The leukocyte-poor platelet concentrate prepared by the described filtration procedure may be used as a blood component in transfusion therapy to prevent or delay platelet alloimmunization.
Koerner
K
K
DRK-Blutspendezentrale Ulm, FRG.
D001793:Blood Preservation; D001803:Blood Transfusion; D002469:Cell Separation / Q000295:instrumentation*; D002482:Cellulose / Q000031:analogs & derivatives; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D007958:Leukocyte Count; D010976:Platelet Count; D017713:Platelet Transfusion
C005062:acetylcellulose; D002482:Cellulose