Transfer of experimental allergic neuritis with P2-reactive T-cell lines.
Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.
Rostami
A
A
Burns
J B
JB
Brown
M J
MJ
Rosen
J
J
Zweiman
B
B
Lisak
R P
RP
Pleasure
D E
DE
D000818:Animals; D000941:Antigens / Q000276:immunology; D002460:Cell Line; D007116:Immunization, Passive; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000941:Antigens; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein