Prediction of the conformation and antigenic determinants of the V-sis viral oncogene product homologous with human platelet-derived growth factor.
In an extensive study involving unification of secondary structure prediction methods to predict peptide backbone angles, folding simulations, and interactive graphics we have calculated conformations for a 160 residue p28sis protein fragment. We demonstrate that the state of the art is sufficient to aid artificial vaccine design.
Robson
B
B
Platt
E
E
Finn
P W
PW
Millard
P
P
Gibrat
J F
JF
Garnier
J
J
D000956:Antigens, Viral; D003201:Computers; D000939:Epitopes; D005814:Genes, Viral; D006801:Humans; D008958:Models, Molecular; D020575:Oncogene Proteins v-sis; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D011487:Protein Conformation; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics; D014764:Viral Proteins / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D020575:Oncogene Proteins v-sis; D010982:Platelet-Derived Growth Factor; D014764:Viral Proteins