title: [Prenatal diagnosis of neural tube and abdominal wall defects in the 2d trimester].
abstract: Combined alpha-fetoprotein screening in serum and specified sonographic examination has proved useful in prenatal diagnosis of neural tube and abdominal wall malformations. 207 amniocenteses were performed within a period of 3 years due to pathologic serum alpha-fetoprotein values and/or abnormal sonographic findings. 101 amniotic fluid specimens showed an increase of alpha-fetoprotein of more than 2.5 times the average value. 60 malformed neural tubes, 17 foetuses with abdominal wall defects, as well as 2 other malformations, were diagnosed. "Open" defects, as well as 17 false positive AFP values, were discovered through the electrophoretic presence of ZNS-specific acetylcholinesterase in the amniotic fluid.
authors.forename: K
authors.initials: K
authors.lastname: Mühlhaus
authors.forename: H K
authors.initials: HK
authors.lastname: Weitzel
authors.forename: J
authors.initials: J
authors.lastname: Schneider
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple / Q000175:diagnosis; D000110:Acetylcholinesterase / Q000378:metabolism; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000201:enzymology; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods*; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase
vernacular_title: Pränatale Diagnostik von Neuralrohr- und Bauchwanddefekten im II. Trimenon.