Early detection of hereditary medullary thyroid cancer with polymorphic DNA probes. Groupe d'Etude des Tumeurs a Calcitonine.
We have performed linkage analysis on 32 families with hereditary medullary thyroid cancer (MTC) with seven polymorphic DNA probes situated near the centromere of chromosome 10. Nineteen of these families were affected with multiple endocrine neoplasia type 2A (MEN 2A), and the remainder had MTC without pheochromocytoma. There were no instances of recombination between the MEN 2A susceptibility gene and the IRBP.H4 marker. Two other probes, TB14.34 and MCK2, are also tightly linked (theta = 0.00 and theta = 0.02, respectively). Because TB14.34 and IRBP.H4/MCK2 are situated on opposite sides of the MEN 2A gene, screening with flanking DNA markers is now feasible.
Narod
S A
SA
Sobol
H
H
Schuffenecker
I
I
Ezekowitz
R A
RA
Lenoir
G M
GM
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000235:genetics; D015342:DNA Probes; D005190:Family; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000235:genetics; D010673:Pheochromocytoma / Q000175:diagnosis / Q000235:genetics; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics*
D015342:DNA Probes