[The significance of serum leucine aminopeptidase (P-LAP) determination in the gynecological malignancies].
We determined Placental-Leucine Aminopeptidase (P-LAP) activity, one of the oncodevelopmental antigens, in sera and in tissues of patients with gynecological cancers. The incidence of P-LAP activity and clinical usefulness of the determination of serum P-LAP activity were studied. The mean level in healthy non-pregnant sera used as controls was 6.0 +/- 2.4mg/dl/h. The mean level of P-LAP activity in patients with benign tumors such as myoma uteri and benign ovarian tumor did not increase in comparison with the controls. The mean level of P-LAP activity in patients with malignant tumor increased with advancing stages, and especially in advanced cervical and ovarian cancer, serum P-LAP levels were significantly higher than in the controls. Serum P-LAP activity correlated with the serum ferritin concentration (r=0.613), but not with the serum alpha-fetoprotein and serum carcinoembryonic antigen concentration. Serial measurements of serum P-LAP activities in patients with gynecological cancer showed that serum P-LAP activity might reflect the progress of cervical and ovarian cancer. Tissue P-LAP activities in 29 ovarian cancers were compared with those in normal tissues. Tissue P-LAP activities in 26 cases out of 29 increased to twice as high as the mean activities in 10 normal ovaries. Our present results suggest the possibility of using P-LAP activity as one of tumor markers for gynecological malignant tumors.
Kobayashi
H
H
Sakura
H
H
Kurauchi
O
O
Mizutani
S
S
D000328:Adult; D000368:Aged; D005260:Female; D005293:Ferritins / Q000097:blood; D005833:Genital Neoplasms, Female / Q000201:enzymology*; D006801:Humans; D007889:Leiomyoma / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology; D010053:Ovary / Q000201:enzymology; D002583:Uterine Cervical Neoplasms / Q000201:enzymology; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins; D005293:Ferritins; D007931:Leucyl Aminopeptidase