Chronic myelogenous leukemia following radiation therapy for testicular seminoma.
A 43-year-old man was treated with orchiectomy and radiotherapy for testicular seminoma. Four years later, he developed a typical Philadelphia chromosome positive chronic granulocytic leukemia. Since the patient was not eligible for bone marrow transplantation, he was treated with busulfan. Long term follow-up of patients who received radiotherapy for testicular seminoma is warranted in order to detect possible secondary tumors.
Iurlo
A
A
Istituto di Scienze Mediche, Milano, Italy.
Foa
P
P
Maiolo
A T
AT
Polli
E E
EE
D000328:Adult; D002066:Busulfan / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D008297:Male; D009919:Orchiectomy; D010677:Philadelphia Chromosome; D011832:Radiation Injuries; D013736:Testicular Neoplasms / Q000532:radiotherapy* / Q000601:surgery
D002066:Busulfan