Mechanism of anti-ulcer effect of calf blood extract.
The mechanism of anti-ulcer effect of Solcoseryl, an extract from calf blood, was studied. Solcoseryl (10 ml/kg, i. v.) increased basal and chemically reduced potential difference of the gastric mucosa in rats. Solcoseryl (1-10 ml/kg, i.v.) also increased gastric mucosal blood flow and gastroduodenal HCO3- secretion. These results indicate that Solcoseryl has a mucosal protective effect which may contribute to the mechanism of its anti-ulcer effect.
Onodera
S
S
Ome Research Laboratories, Tobishi Pharmaceutical Co., Ltd., Ome-shi, Japan.
Takenaga
K
K
Yoshinaga
M
M
Nakase
K
K
Yoshida
S
S
Senga
Y
Y
D000183:Actihaemyl / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001639:Bicarbonates / Q000378:metabolism; D001696:Biomechanical Phenomena; D004386:Duodenum / Q000378:metabolism; D004594:Electrophysiology; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D014020:Tissue Extracts; D000183:Actihaemyl; D000431:Ethanol; D001241:Aspirin; D007213:Indomethacin