Comparison of pharmacokinetic and cell binding properties of turkey Cu-SOD and E. coli Mn-SOD.
The pharmacokinetics in rats and cell fixation properties of coli Mn-SOD are compared with those of Cu-SODs extracted from turkey blood. Despite similarities in molecular weight and pl the different enzymes show different characteristics. The results are discussed with respect to the mechanism of anti-inflammatory activity of superoxide dismutase.
Spasic
M
M
Institut de Biologie Physico-Chimique, Paris, France.
Durosay
P
P
Puget
K
K
Michelson
A M
AM
D000818:Animals; D004912:Erythrocytes; D004926:Escherichia coli / Q000201:enzymology*; D006801:Humans; D008081:Liposomes; D008297:Male; D008345:Manganese; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism / Q000493:pharmacokinetics*; D014422:Turkeys
D008081:Liposomes; D008345:Manganese; D013482:Superoxide Dismutase