title: Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats.
abstract: Groups of 10 goats, harbouring both naturally acquired and experimental infections of gastrointestinal nematodes, were drenched with either levamisole (5 mg kg-1), albendazole (3.8 mg kg-1) or parbendazole (15 mg kg-1), or remained untreated. Haemonchus contortus was the numerically dominant infection, with Strongyloides papillosus, Trichostrongylus colubriformis and Oesophagostomum columbianum also present. At 5-6 days post-treatment, goats were killed and necropsied. Post-mortem worm counts showed that the reduction in mean total worm burdens was 57.4% in levamisole-treated animals, 71.1% in the albendazole group and 85.1% in the parbendazole group. Reductions for H. contortus were 80.2, 87.9 and 83.9% in the levamisole-, albendazole- and parbendazole-treated groups, respectively. These data indicate that the anthelmintics in question are not being applied at an adequate dose rate for goats, and/or resistance to anthelmintics is occurring in the field in Pernambuco State, northeast Brazil.
authors.affiliation: Laboratório de Sanidade Animal, Centro de Pesquisa Agropecuária do Trópico Semi-arido (EMBRAPA-CPATSA), Petrolina-PE, Brazil.
authors.forename: T P
authors.initials: TP
authors.lastname: Charles
authors.forename: J
authors.initials: J
authors.lastname: Pompeu
authors.forename: D B
authors.initials: DB
authors.lastname: Miranda
mesh_terms: D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D001938:Brazil; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D007978:Levamisole; D015766:Albendazole; C100292:parbendazole