title: Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans.
abstract: Hexakis (methoxyisobutilisonitrile) technetium(I), 99mTc-MIBI, has been proposed for myocardial perfusion studies. We have evaluated the biodistribution of this new agent in normal volunteers at rest and after stress. The biodistribution of 99mTc-MIBI is characterized by rapid blood clearance and a consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gallbladder at 1 h after injection, and the best target to non target ratio is observed at 60-90 min after injection. Absorbed radiation dose calculations show that the thyroid is the critical target organ (230 mRad/mCi at rest), presumably because of 99mTc-pertechnetate generated in vivo. Our results indicate that 99mTc-MIBI is a promising tracer for myocardial perfusion imaging.
authors.affiliation: Department of Nuclear Medicine, Istituto San Raffaele, Milano.
authors.forename: A
authors.initials: A
authors.lastname: Savi
authors.forename: P
authors.initials: P
authors.lastname: Gerundini
authors.forename: P
authors.initials: P
authors.lastname: Zoli
authors.forename: L
authors.initials: L
authors.lastname: Maffioli
authors.forename: A
authors.initials: A
authors.lastname: Compierchio
authors.forename: F
authors.initials: F
authors.lastname: Colombo
authors.forename: M
authors.initials: M
authors.lastname: Matarrese
authors.forename: E
authors.initials: E
authors.lastname: Deutsch
mesh_terms: D000328:Adult; D003326:Coronary Circulation; D006321:Heart / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D008297:Male; D009570:Nitriles / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D014018:Tissue Distribution
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi