Influence of the fluid balance on the cortisol and glucose responses to transurethral prostatic surgery.
The serum cortisol and blood glucose concentrations were followed for up to 2 h after 35 transurethral prostatic resections performed under epidural anaesthesia. No significant variation in either of these levels was recorded in connection with the seven operations during which there was no disturbance of the fluid balance, or the seven where there was elevation in the central venous pressure indicative of intravenous fluid overload. In contrast, both the serum cortisol and the blood glucose level showed a significant increase in the nine patients with a blood loss of more than 800 ml, and in the nine recording absorption of irrigant in excess of 300 ml and immediate development of hyponatraemia. On the other hand, this response did not occur in the three patients with irrigant absorption where hyponatraemia developed with a delay of at least 20 min. These results suggest that the effect of surgery on the serum cortisol and blood glucose levels may be modified by disturbances of the fluid balance developing in the course of the operation.
Hahn
R G
RG
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
D000042:Absorption; D000368:Aged; D000767:Anesthesia, Epidural; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure / Q000502:physiology; D002496:Central Venous Pressure / Q000502:physiology; D005998:Glycine / Q000008:administration & dosage; D006470:Hemorrhage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011468:Prostatectomy / Q000379:methods*; D012965:Sodium Chloride / Q000008:administration & dosage; D007507:Therapeutic Irrigation; D014882:Water-Electrolyte Balance / Q000502:physiology*
D001786:Blood Glucose; D012965:Sodium Chloride; D005998:Glycine; D006854:Hydrocortisone