Improvement of peripheral circulation by low density lipoprotein adsorption.
Low density lipoprotein (LDL) was removed by repeated extracorporeal adsorption with a dextran sulphate cellulose column in 5 patients with clinical signs of poor peripheral circulation. The LDL apheresis was continued for 2 to 10 months, and symptoms such as cold or "heavy" legs, or intermittent claudication rapidly improved early in the treatment course in all 5 patients. Clearing of mentation occurred in 3, and recovery of kidney function was seen in 1 patient. These improvements occurred concomitant with a reduction in LDL level.
Agishi
T
T
Department of Surgery, Kidney Center, Tokyo Women's Medical College, Japan.
Kitano
Y
Y
Suzuki
T
T
Miura
A
A
Murakami
J
J
Minagawa
H
H
Ban
K
K
D000368:Aged; D000369:Aged, 80 and over; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000628:therapy*; D001781:Blood Component Removal; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000628:therapy*; D007511:Ischemia / Q000097:blood / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL