Distribution of plasma alpha-1-B-glycoprotein phenotypes in several Mongoloid populations of East Asia.
The distribution of plasma alpha 1B-glycoprotein (alpha 1B) phenotypes was determined by a simple method of two-dimensional electrophoresis followed by protein staining in a group of 1,154 individuals from 8 Mongoloid populations of East Asia. The sample comprised 581 Chinese from different localities (Singapore: 204; Taiwan: 150; Fujien and Hopeh provinces of eastern China: 146 and 81), 155 Koreans, 155 Filipinos, 152 Thais and 111 Malays. Altogether, 6 different alpha 1B phenotypes (1-1, 1-2, 2-2, 1-3, 2-3, and 1-6) were observed. The alpha 1B allele frequencies were very similar in all of the populations. The frequency of A1B*1 varied from 0.89 to 0.91 and that of A1B*2 from 0.08 to 0.10. The A1B*3 allele, reported previously only in American blacks, was observed with a frequency range of 0.003-0.01 in 3 of the Chinese populations, in Koreans and in Malays. A new alpha 1B allele (A1B*6) was observed in 2 Chinese individuals.
Juneja
R K
RK
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
Saha
N
N
Gahne
B
B
Tay
J S
JS
D000328:Adult; D000483:Alleles; D001210:Asia, Southeastern; D044466:Asian People / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D005202:Asia, Eastern; D005260:Female; D005787:Gene Frequency; D006023:Glycoproteins; D006801:Humans; D007136:Immunoglobulins; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
C048566:A1BG protein, human; D001798:Blood Proteins; D006023:Glycoproteins; D007136:Immunoglobulins