[Tumor associated markers as organ-specific antigens of the human seminal plasma. II. Immunohistological studies].
The serologically detected and immunochemically characterized Ca 19-9 antigen of the human seminal plasma (as a glycoprotein) could now be also immunohistochemically localized in the prostate gland as well as in the seminal vesicles of the human genital tract. We conclude, therefore, that the main biosynthesis of this organ-typical glycoprotein takes place in both tissues. With respect to the quantitative expression of the antigen, there are differences not only in connection with the property of Lewis blood group but obviously also with regard to functional tissue alterations partly dependent on hormones. Possible associations with infertility, autoimmune diseases, or AIDS cannot be excluded in case of this alloantigen containing neuraminic acid.
Dienst
C
C
Uhlenbruck
G
G
Heising
J
J
Höller
U
U
Dreessen
C
C
D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002277:Carcinoma / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007983:Lewis Blood Group Antigens / Q000276:immunology; D008297:Male; D009928:Organ Specificity; D011467:Prostate / Q000276:immunology; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000276:immunology*; D011471:Prostatic Neoplasms / Q000276:immunology*; D012661:Semen / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D007983:Lewis Blood Group Antigens
Tumor-assoziierte Marker als organ-charakteristische Antigene des menschlichen Seminalplasmas. II. Immunhistologische Studien.