title: Cerebral blood flow and glucose metabolism in experimental brain edema.
abstract: The relationship between cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMRgl) in the white matter was studied in a plasma infusion model of vasogenic edema in cats. Local CBF, as determined by iodoantipyrine testing, was found to be significantly decreased in edematous white matter (mean +/- standard error of the mean: 17.3 +/- 1.5 ml/100 gm/min) when compared with CBF in the contralateral control white matter (24.8 +/- 1.8 ml/100 gm/min). When the values for edematous brain were corrected for dilution, however, the local CBF averaged 25.3 +/- 1.7 ml/100 gm/min, which was similar to the control value. Local CMRgl was found to be significantly increased in plasma-infused white matter (16.3 +/- 2.2 mumol/100 gm/min) compared with that in control white matter (10.7 +/- 1.3 mumol/100 gm/min). This difference remained, despite correction for dilution and recalculation of local CMRgl values based on altered kinetic constants found in edematous brain. A similar increase in local CMRgl was noted with saline-infusion edema. It is concluded that the increased tissue water level does not alter CBF, but does induce an increase in anaerobic metabolism.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: L N
authors.initials: LN
authors.lastname: Sutton
authors.forename: D
authors.initials: D
authors.lastname: Barranco
authors.forename: J
authors.initials: J
authors.lastname: Greenberg
authors.forename: S
authors.initials: S
authors.lastname: Dante
authors.forename: S
authors.initials: S
authors.lastname: Florin
authors.forename: F
authors.initials: F
authors.lastname: Welsh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000378:metabolism / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose; D005947:Glucose / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D003847:Deoxyglucose; D005947:Glucose