[Beta1- and beta2-adrenergic effects on thrombocytopoiesis in rats].
The influence of beta 1- and beta 2-adrenergic agent injections to rats during 3 days, on the main parameters of thrombocytopoiesis: platelet number and per cent of build up 75seleno-methionine in newly-formed platelets of rats has been studied. It is established that beta 1-adreno-stimulation with dobutamine (DB) increases both the number of platelets and the per cent of build up isotope. Practolol (PC), a beta 1-adrenergic blocking agent, used separately, and combined application of PC + DB lowered significantly the parameters studied. Salbutamol stimulation of beta 2-adrenergic receptors induced an insignificant rise in the thrombocytopoiesis parameters. beta 1-adreno-stimulation with DB results in activation, while beta 1-adrenoblocking with PC--in suppression of thrombocytopoiesis. Pretreatment with PC prevents DB stimulating effect on thrombocytopoiesis, thus evidencing the beta 1-adrenoceptor dependence on the process.
Ganchev
T S
TS
Negrev
N N
NN
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D012645:Selenomethionine
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D012645:Selenomethionine
Beta1- i beta2-adrenergicheskie vliianiia na trombotsitopoéz u krys.