Complement C6 and C7 polymorphisms in Japanese patients with chronic glomerulonephritis.
C6 and C7 types were studied in 158 Japanese patients with different types of chronic glomerulonephritis: 75 patients with IgA nephropathy (IgA-N); 49 patients with idiopathic membranous nephropathy (IMN), and 34 patients with minimal-change nephrotic syndrome (MCNS). There were significant differences in the C6 and C7 allele and phenotype frequencies between the patient groups and controls. A strong association was found between IgA-N and C7 5 phenotype (p less than 0.001, RR = 12.71), and between MCNS and C7 5 phenotype (p less than 0.001, RR = 14.20). A significant association between MCNS and C6 B2 phenotype (p less than 0.05, RR = 2.42) was also found. In the IMN patient group, a significant association with C7 4 phenotype (p less than 0.05, RR = 2.42) was observed. Thus, C6 and C7 phenotypes may be causative factors in the development of chronic glomerulonephritis.
Nishimukai
H
H
Department of Legal Medicine, School of Medicine, Ehime University, Japan.
Nakanishi
I
I
Takeuchi
Y
Y
Sumiyoshi
R
R
Mizutani
K
K
Iida
N
N
Shinomiya
T
T
D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D005787:Gene Frequency; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D015433:Glomerulonephritis, Membranous / Q000235:genetics*; D006801:Humans; D007564:Japan; D009402:Nephrosis, Lipoid / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D003183:Complement C6; D003184:Complement C7