The effect of DQ-2511, a newly synthesized anti-ulcer drug, on the gastric mucosal hemodynamics and ulceration in rats.
DQ-2511, which is a dopamine derivative, is a newly synthesized anti-ulcer drug. Pretreatment with DW-2511 in the hemorrhagic shock-reperfusion model in rats significantly prevented the decreases of gastric mucosal blood volume, mucosal blood oxygenation index and the ulcer formation. The decrease in gastric mucosal blood oxygenation index in hemorrhagic shock state has a linear correlation with the size of the mucosal ulcers both in DQ-2511 and control groups. The results suggested that DQ-2511 exerts its anti-ulcer activity by improving mucosal hemodynamics in hemorrhagic shock-reperfusion rat model.
Tanimura
H
H
Department of Medicine, Osaka University Medical School, Japan.
Sato
N
N
Kawano
S
S
Tsujii
M
M
Hayashi
N
N
Sakura
H
H
Tsujii
S
S
Ogihara
T
T
Kamada
T
T
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005753:Gastric Mucosa / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010100:Oxygen / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000097:blood / Q000150:complications / Q000503:physiopathology; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D001549:Benzamides; C058308:ecabapide; D010100:Oxygen