Neurotrophic effect of cholecystokinin on ventral spinal cord in culture.
Studies of the effect of cholecystokinin on organotypic cultures of rat ventral spinal cord revealed that concentrations of 10(-4) to 10(-14) M exert a marked growth-stimulating effect. In the presence of cholecystokinin, the neuritic extension of the ventral spinal cord exceeds control values 3.5-6.5 times. The growth zone of spinal cord explants increases in cholecystokinin-treated cultures. The possible mechanism of the trophic effect of cholecystokinin on the ventral spinal cord is discussed briefly.
Iwasaki
Y
Y
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Japan.
Kinoshita
M
M
Ikeda
K
K
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002766:Cholecystokinin / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects
D009414:Nerve Growth Factors; D002766:Cholecystokinin