Effect of GRF and somatostatin on 7B2 secretion by rat GH1 cells.
A novel pituitary protein "7B2" was secreted by GH1 cells. The secretion of 7B2 was increased in the presence of human GRF in a dose-responsive manner. In contrast, a somatostatin analog, SMS 201-995, revealed the inhibitory effects on the basal- and GRF-induced secretion of 7B2 at the concentration of 10(-7) M. These findings suggest that 7B2 is a secretory protein of rat GH1 cells under certain conditions.
Iguchi
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H
Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan.
Natori
S
S
Nawata
H
H
D000236:Adenoma / Q000378:metabolism*; D000818:Animals; D002850:Chromatography, Gel; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D015282:Octreotide / Q000494:pharmacology; D010907:Pituitary Hormones / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D010907:Pituitary Hormones; C497680:Scg5 protein, rat; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D015282:Octreotide; D011188:Potassium