title: Radical radiotherapy for muscle invasive transitional cell carcinoma of the bladder: failure analysis.
abstract: Patients with muscle invasive carcinoma of the bladder treated with radical radiation were prospectively documented and followed in an attempt to identify prognostic factors predictive of the response to treatment. Data on 121 consecutive patients treated with radical radiation between 1981 and 1985 are presented. Over-all actuarial survival of the patient population (median age 70 years) was 31.6% at 5 years and cause-specific survival was 44.8%. At analysis 33 of 121 patients (27.3%) were alive with preserved bladder function. Independent prognostic factors for cause-specific survival and for complete response with radical radiation were tumor configuration, hemoglobin level and clinical stage. The rate free of local relapse was significantly influenced by stage and presence of coexistent carcinoma in situ. The study suggests that factors other than stage and grade influence prognosis in invasive bladder cancer and should be considered in interpreting treatment results.
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: M K
authors.initials: MK
authors.lastname: Gospodarowicz
authors.forename: N V
authors.initials: NV
authors.lastname: Hawkins
authors.forename: G A
authors.initials: GA
authors.lastname: Rawlings
authors.forename: J G
authors.initials: JG
authors.lastname: Connolly
authors.forename: M A
authors.initials: MA
authors.lastname: Jewett
authors.forename: G M
authors.initials: GM
authors.lastname: Thomas
authors.forename: J G
authors.initials: JG
authors.lastname: Herman
authors.forename: P G
authors.initials: PG
authors.lastname: Garrett
authors.forename: T
authors.initials: T
authors.lastname: Chua
authors.forename: W
authors.initials: W
authors.lastname: Duncan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D015653:Cystectomy; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*