Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.
Activities of Acetylcholinesterase (AChE) in brain and erythrocytes, pseudocholinesterase (PChE) in plasma and non-specific carboxylesterase (NSE) in brain, liver, plasma and kidney were assayed at weekly intervals in growing male rats fed dietary pirimiphos-methyl at dosages of 1000, and 1500 ppm for a period of 28 days. Significant inhibition of tissue esterases were observed at the end of 7 days at both the dosages and the enzyme activities remained markedly inhibited at subsequent intervals. Activities of all enzymes (excepting Brain AChE) returned to normal levels following a 7-day maintenance on the insecticide-free diet implicating that pirimiphos-methyl induced little or no permanent tissue damage. The results suggest that plasma NSE level may also serve as a sensitive indicator in monitoring OPI exposure.
Rajini
P S
PS
Infestation Control & Protectants Department, Central Food Technological Research Institute, Mysore, India.
Muralidhara
Krishnakumari
M K
MK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000097:blood; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors* / Q000097:blood; D002800:Cholinesterase Inhibitors; D004032:Diet; D004435:Eating / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology; D007306:Insecticides / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D051381:Rats
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014153:pirimiphos methyl; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D002091:Butyrylcholinesterase