[Preliminary report on the clinical application of anti-Jo-1 antibody].
Jo-1 antigen was purified from the rabbit thymus acetone powder. Using it as antigen, we found anti-Jo-1 antibody in 25% of polymyositis, 7.1% in dermatomyositis, none in other connective tissue diseases nor non-connective tissue diseases. Other antinuclear antibodies, eg anti-RNP, anti-SSA were also found in our polymyositis-dermatomyositis patients. Our study suggested, the positivity of anti-Jo 1 antibody not only confirmed the patient's diagnosis of polymyositis but also demonstrated the autoimmune pathogenesis of this disease.
Dong
Y
Y
Cheng
P C
PC
Zhang
N C
NC
D000974:Antibodies, Antinuclear / Q000032:analysis*; D003240:Connective Tissue Diseases / Q000276:immunology*; D006801:Humans; D009220:Myositis / Q000276:immunology*
D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody