A classification of essential hypertensive patients according to the erythrocyte Na transport abnormalities: an application for monitoring the antihypertensive response to cicletanide.
We have studied the kinetic properties of the interaction of internal Na with four different Na transport pathways (ouabain-sensitive Na, K pump, bumetanide-sensitive Na,K cotransport, Li:Na countertransport and passive Na permeability) in erythrocytes from 197 essential hypertensive patients. This study permitted us to classify 168 of the 197 hypertensives studied into the following groups: Pump - hypertensives-six patients showing low pump affinity for internal Na and high maximal pump rate; Co - hypertensives -95 patients characterized by low cotransport affinity for internal Na and low or normal maximal outward cotransport rate. Counter + hypertensives - 35 patients characterized by low countertransport affinity for internal Na and high maximal countertransport rate; and Leak + hypertensives - 32 patients showing increased passive Na permeability. Having studied the apparent affinity of the Na,K cotransport system for external K we divided the co - hypertensives into three subgroups (symmetric, asymmetric or antisymmetric) according to the presence of low, normal or high K affinity. Forty-five hypertensive patients were submitted to antihypertensive treatment with a new diuretic and antihypertensive drug, cicletanide. Preliminary results indicate that one of the factors involved in the antihypertensive efficiency of the compound is the subgroup to which the hypertensive belongs.
Garay
R
R
Nazaret
C
C
Hannaert
P
P
Price
M
M
Diez
J
J
Dagher
G
G
Deschamps de Paillette
E
E
Juin
G
G
Braquet
P
P
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001692:Biological Transport; D004232:Diuretics / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000145:classification* / Q000188:drug therapy; D007473:Ion Channels / Q000378:metabolism; D008094:Lithium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D011725:Pyridines; D012964:Sodium / Q000097:blood* / Q000378:metabolism
D000959:Antihypertensive Agents; D004232:Diuretics; D007473:Ion Channels; D011725:Pyridines; D008094:Lithium; D012964:Sodium; C038068:cicletanine; D011188:Potassium