Comparative in-vitro activity of twenty antimicrobial agents against clinical isolates of Mycobacterium avium complex.
The in-vitro susceptibility of Mycobacterium avium complex isolates, obtained from immunosuppressed patients with and without the Acquired Immunodeficiency Syndrome (AIDS), to various antimicrobial agents was determined. Amikacin, the 4-quinolone compounds--ciprofloxacin, temafloxacin and PD 117558--and the penem SCH 34343 were active against most of the isolates. In-vitro synergism using selected antimicrobial combinations could not be demonstrated. No differences in the susceptibility, depending upon the source of the isolates (AIDS or non-AIDS), were noted.
Khardori
N
N
Department of Medical Specialities, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Rolston
K
K
Rosenbaum
B
B
Hayat
S
S
Bodey
G P
GP
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003470:Culture Media; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D003470:Culture Media