title: Diuretic and natriuretic properties of fenoldopam in chronic renal failure.
abstract: The effect of intravenously administered fenoldopam on diuresis and natriuresis was investigated in a group of 10 patients with advanced chronic renal failure. After an initial basal period of 1 h, a fenoldopam infusion was started and maintained for 12 h at rates varying between 0.025 and 0.1 microgram/kg per min. During the study, blood pressure was measured every 10 min and urine volume, natriuresis and creatinine clearance were measured hourly. Fenoldopam induced a significant increase in urine volume, natriuresis and creatinine clearance (P less than 0.05-0.001) accompanied by a small but significant drop in blood pressure (P less than 0.05-0.01). These results show that for advanced chronic renal failure, fenoldopam has diuretic and natriuretic properties that could be of clinical relevance.
authors.affiliation: 12 de Octubre Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Andrés
authors.forename: R
authors.initials: R
authors.lastname: García-Robles
authors.forename: J M
authors.initials: JM
authors.lastname: Alcázar
authors.forename: C
authors.initials: C
authors.lastname: Alvarez
authors.forename: J
authors.initials: J
authors.lastname: Martínez
authors.forename: A
authors.initials: A
authors.lastname: Oliet
authors.forename: J
authors.initials: J
authors.lastname: Sancho
authors.forename: J L
authors.initials: JL
authors.lastname: Rodicio
authors.forename: L M
authors.initials: LM
authors.lastname: Ruilope
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004231:Diuresis / Q000187:drug effects* / Q000502:physiology; D015259:Dopamine Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D018818:Fenoldopam; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology; D009318:Natriuresis / Q000187:drug effects* / Q000502:physiology
chemical_list: D015259:Dopamine Agents; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D018818:Fenoldopam