Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?
Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions. The interaction of nonsteroidal antiinflammatory agents and beta-blockers and their role in the control of blood pressure in obstetrics are discussed. Indomethacin should not be given to pregnant patients with hypertension treated with beta-blockers.
Schoenfeld
A
A
Department of Obstetric and Gynecology, Beilins on Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.
Freedman
S
S
Hod
M
M
Ovadia
Y
Y
D000328:Adult; D000959:Antihypertensive Agents / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D010869:Pindolol / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000627:therapeutic use
D000959:Antihypertensive Agents; D011433:Propranolol; D010869:Pindolol; D007213:Indomethacin