title: [Serum anti-protease activity in the evaluation of results of proton hypophysectomy].
abstract: The activity of the alpha 1-antitrypsin and alpha 2-macroglobulin were studied in 16 breast cancer patients and 25 hypophyseal adenoma patients prior to and at varying time after proton "hypophysectomy". A high alpha 1-antitrypsin level and a normal alpha 2-macroglobulin level were found in all the breast cancer patients. An increase in both blood serum inhibitors was detected in hypophyseal adenoma. The dependence of the alpha 1-antitrypsin content on a subclinical stage of generalized metastatic spread was revealed in the course of 2 years following "hypophysectomy" in the patients with disseminated breast cancer. In the hypophyseal adenoma patients the activity of both inhibitors returned to normal 1 year after treatment and remained within normal during 3 years of follow-up. It was regarded as a positive therapeutic effect. The above findings make it possible to propose the determination of the activity af alpha 1-antitrypsin in breast cancer and alpha 1-antitrypsin and alpha 2-macroglobulin in hypophyseal adenoma as an additional test for the evaluation of the results of proton "hypophysectomy".
authors.forename: L A
authors.initials: LA
authors.lastname: Konnova
authors.forename: B A
authors.initials: BA
authors.lastname: Konnov
authors.forename: O P
authors.initials: OP
authors.lastname: Zargarova
authors.forename: L A
authors.initials: LA
authors.lastname: Mel'nikov
authors.forename: V E
authors.initials: VE
authors.lastname: Komar
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000378:metabolism / Q000532:radiotherapy; D001943:Breast Neoplasms / Q000097:blood* / Q000628:therapy; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000097:blood* / Q000378:metabolism / Q000532:radiotherapy; D011379:Prognosis; D011480:Protease Inhibitors / Q000097:blood*; D011522:Protons; D013997:Time Factors; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D011480:Protease Inhibitors; D011522:Protons; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D013006:Growth Hormone
vernacular_title: Antiproteaznaia aktivnost' syvorotki krovi pri otsenke rezul'tatov protonnoĭ "gipofizéktomii".