Gastric mucosal protective action of endothelium-derived relaxing factor.
The change in the endothelial function by the application of 0.6 N HCl and the effects of endothelium-derived relaxing factor (EDRF) inhibitors and nitrites on HCl-induced lesions were studied to clarify the effect of EDRF on gastric lesions in rats. The EDRF-induced increase in the gastric mucosal hemodynamics induced by vagal stimulation or intra-arterial administration of acetylcholine was inhibited by the EDRF inhibitors or removal of endothelial cells. Topical application of 0.6 N HCl on the exposed gastric mucosa abolished the response of the mucosal hemodynamics to acetylcholine or vagal stimulation. Gastric lesions induced by 0.45 N HCl were enhanced by EDRF inhibitors or removal of endothelial cells from gastric submucosal arterioles.
Kitagawa
H
H
Department of Pharmacology, Kawanishi Pharma Research Institute, Japan.
Takeda
F
F
Kohei
H
H
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013458:Sulfur Dioxide / Q000378:metabolism
D006454:Hemoglobins; D013458:Sulfur Dioxide; D009569:Nitric Oxide; D006851:Hydrochloric Acid