title: Clinical correlates and prognostic significance of type A behavior and silent myocardial ischemia on the treadmill.
abstract: Type A patients with coronary artery disease (CAD) tend to ignore or underreport symptoms, especially during challenging tasks such as the treadmill exercise test. To determine whether type A CAD patients might be more likely than type B patients to have silent ischemia during exercise and consequently a worse prognosis, 403 patients with stable CAD who had significant coronary disease on angiography, a positive Bruce protocol treadmill test and a structured interview to assess type A behavior were studied. Median follow-up time was 6 years. Type A patients were more likely to experience silent ischemia during exercise than were type B patients (35 vs 25%, p = 0.05). Patients with silent ischemia during exercise had a history of fewer anginal episodes/week, and type A patients with silent ischemia were less likely to have had a history of typical angina. However, using the Cox model, there were no significant differences in survival between type A patients and B patients with silent ischemia (4-year survival 86 vs 79%, p = 0.44) and no significant differences in survival between type A patients with silent ischemia and type A patients with symptomatic ischemia (6-year survival 86 vs 80%, p = 0.59). Similar results were obtained for infarction-free survival. Type A patients are more likely than type B patients to have silent ischemia during exercise, but long-term survival is not affected.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: W C
authors.initials: WC
authors.lastname: Siegel
authors.forename: D B
authors.initials: DB
authors.lastname: Mark
authors.forename: M A
authors.initials: MA
authors.lastname: Hlatky
authors.forename: F E
authors.initials: FE
authors.lastname: Harrell
authors.forename: D B
authors.initials: DB
authors.lastname: Pryor
authors.forename: J C
authors.initials: JC
authors.lastname: Barefoot
authors.forename: R B
authors.initials: RB
authors.lastname: Williams
mesh_terms: D000787:Angina Pectoris / Q000209:etiology; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D011379:Prognosis; D016019:Survival Analysis; D013997:Time Factors; D014434:Type A Personality