title: Aluminum toxicity and albumin.
abstract: During a study of priming solutions for extracorporeal membrane oxygenation (ECMO) in the intensive care nursery, it was discovered that those solutions using certain brands of 25% albumin contained aluminum levels within the toxic range. When the brand was changed to a brand known to have a lower aluminum (Al) content, a marked drop in priming solution Al levels was measured. The heat exchanger was examined as a possible source of soluble Al. No evidence of elevated Al levels was found in fluids perfusing this heat exchanger when compared with a stainless steel heat exchanger. The Al content of various blood products was evaluated along with various brands of 5% albumin and 25% albumin.
authors.affiliation: Children's Hospital National Medical Center, Dept of Neonatology, Washington, DC 20010.
authors.forename: A T
authors.initials: AT
authors.lastname: Kelly
authors.forename: B L
authors.initials: BL
authors.lastname: Short
authors.forename: T C
authors.initials: TC
authors.lastname: Rains
authors.forename: J C
authors.initials: JC
authors.lastname: May
authors.forename: J J
authors.initials: JJ
authors.lastname: Progar
mesh_terms: D000418:Albumins / Q000008:administration & dosage*; D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D004340:Drug Contamination; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007223:Infant
chemical_list: D000418:Albumins; D000535:Aluminum