Studies on zinc sulphate microcapsules: (III) in vivo evaluation.
Zinc sulphate capsules and syrup were prepared as conventional dosage forms and in vivo experiments were performed for both on the conventional dosage forms as well as on microcapsules. Blood samples were taken from healthy volunteers at 1, 2, 3, 4 and 5 hours and AUC3 and AUC5 were calculated by trapezoidal rule. Relative bioavailability of zinc was calculated and the 5th hour relative bioavailability difference was found to be significant. The results show that zinc sulphate in microcapsule form was able to prolong the action.
Oner
L
L
University of Hacettepe, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara, Turkey.
Arcasoy
A
A
Kas
H S
HS
Hincal
A A
AA
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D006801:Humans; D008297:Male; D012996:Solutions; D013431:Sulfates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019287:Zinc Sulfate
D002214:Capsules; D012996:Solutions; D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc