Expression of an HLA-Bw6-related specificity by the HLA-Cw3 molecule.
Radioimmunoassay of HLA-transformed mouse L cells expressing A3, A24, B7, or Cw3 HLA class I molecules with a set of monomorphic monoclonal antibodies distinguishes between A3-A24 and B7-Cw3 patterns of reactivity. Analyses with Bw6-specific monoclonal antibodies and a human alloantiserum demonstrate the expression by the HLA-Cw3 molecules of a Bw6 public specificity related to but not identical with that expressed by the HLA-B7 molecules. Exon-shuffling experiments and inhibition studies of monoclonal antibody cell-surface fixation indicate that similar parts of B7 and Cw3 molecules account for their serological cross-reactivity.
Layet
C
C
Delovitch
T
T
Ferrier
P
P
Caillol
D H
DH
Jordan
B R
BR
Lemonnier
F A
FA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007120:Immunochemistry; D007518:Isoantibodies / Q000276:immunology; D007739:L Cells / Q000276:immunology; D051379:Mice; D014170:Transformation, Genetic
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens; C038652:HLA-Bw6 antigen; D015236:HLA-C Antigens; C038653:HLA-C*03 antigen; D007518:Isoantibodies