Evidence for a new HLA class II determinant present on cells from HLA-DR1 and/or -DR4 individuals.
Evidence for a new HLA class II specificity is presented. It is recognized by LE serum, which reacts with most DR1 and/or DR4 individuals (r = 0.86). Its frequency in the French population is 0.33. Absorption-elution experiments showed that the serum reactivity was not due to a mixture of anti-DR1 and anti-DR4 antibodies, but to a single antibody population which could be absorbed on and eluted from both DR1(+) or DR4(+) cells. LE specificity seemed to be expressed on DR but not on DQ molecules since the serum reacted with and could be absorbed by DR+,DQw- cells; it did not react with a DR-,DQw+ mutant cell, but did react with the DR+,DQw+ parental cell. The relationship between LE specificity and MC1 and Te23 specificities remains to be determined.
Lepage
V
V
Alcalay
D
D
Douay
C
C
Mallet
C
C
Loiseau
P
P
Degos
L
L
Colombani
M
M
Colombani
J
J
D000328:Adult; D002648:Child; D000939:Epitopes / Q000276:immunology; D005260:Female; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008297:Male
D000939:Epitopes; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies