title: Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer.
abstract: We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M0. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.
authors.forename: M S
authors.initials: MS
authors.lastname: Kies
authors.forename: L I
authors.initials: LI
authors.lastname: Gordon
authors.forename: W W
authors.initials: WW
authors.lastname: Hauck
authors.forename: Y
authors.initials: Y
authors.lastname: Krespi
authors.forename: R H
authors.initials: RH
authors.lastname: Ossoff
authors.forename: B C
authors.initials: BC
authors.lastname: Pecaro
authors.forename: C
authors.initials: C
authors.lastname: Yuska
authors.forename: C H
authors.initials: CH
authors.lastname: Lamut
authors.forename: W N
authors.initials: WN
authors.lastname: Brand
authors.forename: S K
authors.initials: SK
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged
chemical_list: D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate