title: [Platelet-modified LDL: uptake and metabolism in macrophages].
abstract: Mouse peritoneal macrophages accumulate large amounts of cholesterol ester when incubated with chemically or biologically modified lipoproteins. Incubation of LDL with platelet secretory products for 2 hours at 37 degrees C decreases its protein and cholesterol content. Subsequently this modified LDL, named PCM-LDL, enhances in-vitro platelet aggregation. When it is incubated with cultures of macrophages, cholesterol accumulates in the cells and esterification is increased. PCM-LDL is taken up by macrophages via a receptor-mediated mechanism, independent of the scavenger receptor for acetyl-LDL. Its degradation in lysosomes is required for stimulation of cholesterol ester synthesis.
authors.forename: B
authors.initials: B
authors.lastname: Fuhrman
authors.forename: J G
authors.initials: JG
authors.lastname: Brook
authors.forename: M
authors.initials: M
authors.lastname: Aviram
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D010974:Platelet Aggregation
chemical_list: D008077:Lipoproteins, LDL