Radio-opaque liposomes for the improved visualisation of focal liver disease by computerized tomography.
Liposomes laden with radio-opaque agents (ROA) were prepared by the reverse phase evaporation method. The liposome solutions--containing 1.7-2.5 mg iodine per mg lipid--were injected into Wistar rats. 60 min post injection the rats were scanned in a Siemens CT scanner. Following the injection of 260 mg encapsulated iodine per kg bodyweight--less than half the iodine of the normal ROA bolus injection--there was a long lasting arise in liver enhancement of 40 Hounsfield units (HU). In animals with liver tumours induced by nitrosamine lesions of 2-3 mm in diameter could be detected.
Henze
A
A
Department for Gastroenterology and Hepatology, Medizinische Hochschule, Hannover.
Freise
J
J
Magerstedt
P
P
Majewski
A
A
D000818:Animals; D003287:Contrast Media; D004052:Diethylnitrosamine; D005260:Female; D007472:Iohexol / Q000031:analogs & derivatives; D007483:Iothalamic Acid / Q000031:analogs & derivatives; D007485:Ioxaglic Acid; D008081:Liposomes; D008099:Liver / Q000000981:diagnostic imaging; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging*; D051381:Rats; D011919:Rats, Inbred Strains; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids
D003287:Contrast Media; D008081:Liposomes; D014283:Triiodobenzoic Acids; D007483:Iothalamic Acid; C033300:iotrolan; D004052:Diethylnitrosamine; D007472:Iohexol; C038192:iopromide; C019462:meglumine ioglicinate; D007485:Ioxaglic Acid