[Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer].
The paper is devoted to the description of the combined methods of radiotherapy of urinary bladder cancer and the local use of metronidazole. At the 1st stage of therapy a dose of 140 cGy twice a day with 5-6 h interruption was delivered up to a summary dose of 43 Gy on conversion to small fractionation by the TDF factor. Then two fractions at a single dose of 6 Gy once a week were given. Altogether 36 patients were treated by this method. The control group of patients was given radiation therapy in a split course in the regimen of routine fractionation. Short-term therapeutic results were analyzed for both groups. The total positive effect was higher in the study group (81.25% versus 66.7%). A conclusion is that this method holds promise.
Pereslegin
I A
IA
Vinogradskiĭ
A G
AG
Mufazalov
F F
FF
D000283:Administration, Intravesical; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
D008795:Metronidazole
Dinamicheskoe fraktsionirovanie dozy izlucheniia v sochetanii s mestnym primeneniem metronidazola pri rake mochevogo puzyria.