Isoquinoline is a possible anti-psoriatic agent in coal tar.
Isoquinoline has been identified as a component of coal tar which causes interfollicular regions of parakeratotic stratum corneum in mouse tail epidermis to become orthokeratotic, with concomitant production of a granular layer. In this respect it behaves similarly to coal tar itself, and isoquinoline may contribute to the anti-psoriatic activity of coal tar.
Foreman
M I
MI
Taylor
M
M
Clark
C
C
Devitt
H
H
Hanlon
G
G
Kelly
I
I
Lukowiecki
G
G
D000818:Animals; D003033:Coal Tar / Q000494:pharmacology*; D006224:Cricetinae; D004817:Epidermis / Q000187:drug effects* / Q000473:pathology; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D007633:Keratins / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D011565:Psoriasis / Q000188:drug therapy*
D007546:Isoquinolines; D007633:Keratins; D003033:Coal Tar; C039109:isoquinoline