title: Pharmacological studies on the central action of novel benzylidene-imidazothiazolone derivatives.
abstract: Pharmacological studies on the central action of novel benzylidene-imidazothiazolone derivatives were carried out on mice and rats. The highest activity showed two compounds: a chloro- and a methoxy- derivative. They produced analgesic, anticonvulsant, anti-anxiety and "antidepressant" effects in mice.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Kolasa
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: T
authors.initials: T
authors.lastname: Pietrasiewicz
authors.forename: G
authors.initials: G
authors.lastname: Czechowska
authors.forename: K
authors.initials: K
authors.lastname: Kieć-Kononowicz
authors.forename: A
authors.initials: A
authors.lastname: Zejc
mesh_terms: D000700:Analgesics; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007093:Imidazoles; D013844:Thiazoles; D012110:Reserpine; D006220:Haloperidol; D001058:Apomorphine