Cocaine enhances memory storage in mice.
Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage.
Introini-Collison
I B
IB
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
McGaugh
J L
JL
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice
D003042:Cocaine