Local application of growth-factor IGF-1 to healing bone. Experiments with a titanium chamber in rabbits.
In order to study the effects of bone healing, insulin-like growth factor 1 (IGF-1) was continuously applied with a minipump to a healing bone callus located inside a titanium chamber in a rabbit tibia. After 2 weeks, 99mTc-MDP uptake and calcium content were measured. IGF-1 decreased 99mTc-MDP uptake, and thus the mineral turnover rate, but the amount of bone mineral was unchanged. Probably the normal endogenous production of IGF-1 is already optimal for healing in this model.
Aspenberg
P
P
Lund University Hospital Department of Orthopedics, Sweden.
Albrektsson
T
T
Thorngren
K G
KG
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D004343:Drug Implants; D004867:Equipment Design; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D011817:Rabbits; D011877:Radionuclide Imaging; D013002:Somatomedins / Q000494:pharmacology*; D013669:Technetium Tc 99m Medronate; D014025:Titanium; D014945:Wound Healing / Q000187:drug effects*
D004343:Drug Implants; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D014025:Titanium; D002118:Calcium; D013669:Technetium Tc 99m Medronate