title: The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers.
abstract: We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a greater maximum concentration with a similar peak time. The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, especially in the elderly.
authors.affiliation: Medical Department, Pharmaceutical Development, Formenti, Milan.
authors.forename: C
authors.initials: C
authors.lastname: Benvenuti
authors.forename: V
authors.initials: V
authors.lastname: Bottà
authors.forename: M
authors.initials: M
authors.lastname: Broggini
authors.forename: V
authors.initials: V
authors.lastname: Gambaro
authors.forename: F
authors.initials: F
authors.lastname: Lodi
authors.forename: M
authors.initials: M
authors.lastname: Valenti
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D000704:Analysis of Variance; D001381:Azepines / Q000008:administration & dosage* / Q000097:blood; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D001381:Azepines