[Clinical and experimental study on the prescription of jianpi yipi].
According to "Spleen-Stomach" theory, the effect of Jianpi Yiqi prescription (JPYQ) was observed clinically and studied experimentally. 168 cases manifested as Spleen-Qi ( ) deficiency including chronic gastritis and peptic ulcer (84 cases), chronic glomerulonephritis (44 cases) and vomitus gravidarum-edema of pregnancy (40 cases) were treated with JPYQ. Estimation were made based on their clinical conditions. Serum gastrin, serum cholyglycine, blood acetylcholine and cholinesterase, blood 5-HT and histamine were measured before and after treatment. The overall effective rate was 92.9% in gastritis and peptic ulcer group, 86.3% in nephritis group and 100% in pregnancy group respectively. A marked increase of serum glycocholic acid level was shown in gastritis and peptic ulcer and vomitus gravidarum groups. That was considered as the result of the secretion of cholic acid by this prescription. Clinical improvement was also obtained in nephritis group accompanying disappearance of albuminuria in 36.4%. Blood level of 5-HT and histamine lowered to some extent and tended to be normal. Besides, this prescription markedly inhibited electric stimulated excitement on isolated longitudinal muscle strip of guinea pig's ileum. The mechanism could be the inhibition of release of acetylcholine from Auerbach's plexus by this prescription.
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D000328:Adult; D000368:Aged; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy*; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal