Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects.
Salbutamol was administered intravenously to 5 patients with renal function impairment for estimation its pharmacokinetic parameters. The mean terminal half-life was 256 min, similar to previously reported values in healthy adults. The mean clearance (167 ml/min) and the mean volume of distribution (551) were decreased. These parameters were not correlated with the creatinine clearance. A slight but significant decrease was observed in the plasma potassium level up to 125 min after the salbutamol infusion. The heart rate was significantly increased, and the increase in 3 patients was correlated with the salbutamol concentration. The biological effects of the drug were less marked than expected.
Rey
E
E
Département de pharmacologie clinique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France.
Luquel
L
L
Richard
M O
MO
Mory
B
B
Offenstadt
G
G
Olive
G
G
D058186:Acute Kidney Injury / Q000150:complications / Q000378:metabolism*; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy / Q000209:etiology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000652:urine
D000420:Albuterol; D011188:Potassium