Serum F protein estimation in liver allograft recipients with graft dysfunction.
Serum levels of F protein, a 44 kD cytoplasmic protein mainly found in hepatocytes, became elevated during episodes of graft dysfunction following orthotopic liver transplantation. In a study of 27 liver transplant recipients, the rise in F protein did not precede rises in the other conventional biochemical indices of hepatic dysfunction. Serum F protein concentration significantly correlated with serum levels of aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, and bilirubin (all P less than 0.001) and also with the prothrombin time (P = 0.048). Despite its high concentration in liver cells, this marker does not provide any additional benefit in the diagnosis of graft dysfunction or in monitoring liver allograft function following transplantation.
Forbes
G M
GM
Liver Unit, King's College Hospital, London, England.
Oliveira
D B
DB
Hughes
R D
RD
O'Grady
J G
JG
Calne
R Y
RY
Williams
R
R
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000032:analysis*; D025203:Phosphofructokinase-1, Muscle Type; D025221:Phosphofructokinases; D011183:Postoperative Complications / Q000175:diagnosis; D011506:Proteins; D014184:Transplantation, Homologous
D009124:Muscle Proteins; D011506:Proteins; D025221:Phosphofructokinases; D025203:Phosphofructokinase-1, Muscle Type; C026043:PFKM protein, human