[The effect of dopamine on the systemic hemodynamic indices, on the blood supply of an ischemic focus and on the plasma enzyme activity in dogs with acute coronary occlusion].
In acute experiments on anesthetized dogs dopamine (10 micrograms/kg and 10 micrograms/kg/min) was shown to increase significantly the blood supply to ischemic regions and the minute heart volume at the background of insignificant systemic hypotension and tachycardia. When administered in a dose of 10 micrograms/kg/min dopamine increased the magnitude of the ratio of glycogen-phosphorylase b activity to total glycogen-phosphorylase activity in the blood plasma. Administration of 20 micrograms/kg of the drug did not produce a significant increase of the blood supply to ischemic regions and the minute heart volume in the presence of the tendency toward systemic hypotension and bradycardia.
Katkov
E V
EV
Sysoliatina
N A
NA
D000208:Acute Disease; D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D008297:Male; D013997:Time Factors
D004298:Dopamine
Vliianie dofamina na pokazateli sistemnoĭ gemodinamiki, krovosnabzhenie ochaga ishemii i aktivnost' fermentov plazmy u sobak s ostroĭ koronarookkliuzieĭ.