Platelet serotonergic mechanisms and glomerulonephritis.
Proven cases (28) of glomerulonephritis (GN) were evaluated for clinico-biochemical profile, bleeding time, platelet count, platelet aggregation and platelet serotonergic mechanisms. Inordinate increase in platelet aggregation and altered platelet serotonergic mechanisms (reduced 5-HT, uptake, reduced intraplatelet 5-HT and increased plasma 5-HT) were demonstrated in some histopathological types of GN. The mechanisms and importance of these alterations have been discussed.
Mitra
M K
MK
Jain
A K
AK
Misra
R
R
Sethi
P P
PP
Shukla
R N
RN
Chandra
M
M
Verma
M
M
Saxena
A K
AK
Shanker
K
K
D001760:Bleeding Time; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood*; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000097:blood; D010974:Platelet Aggregation; D010976:Platelet Count; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
D012701:Serotonin