The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes.
The XLR sequence family encodes RNA transcripts specific to late-stage T and B cells and their neoplasms. Only one apparently functional mRNA has been identified thus far and this encodes a novel 25 kDa nuclear protein. In this report, we find that the XLR gene family is composed of 50-75 copies per haploid genome which localize to at least two different portions of the mouse X chromosome. Neither of these locations are near the xid mutation that earlier work had correlated with XLR. In addition, some members of this family are also on the Y chromosome. Another surprising finding is that while the fourteen genomic clones examined to date have the same exon-intron structure and are closely related with respect to sequence conservation (90%), all appear (in most cases by multiple criteria) to be non-functional, raising the possibility that all but one of the members of this large semi-dispersed family are pseudogenes.
Garchon
H J
HJ
Department of Microbiology and Immunology, Stanford University School of Medicine, California.
Loh
E
E
Ho
W Y
WY
Amar
L
L
Avner
P
P
Davis
M M
MM
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D003360:Cosmids; D003433:Crosses, Genetic; D005091:Exons; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D005810:Multigene Family; D015345:Oligonucleotide Probes; D011544:Pseudogenes; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000502:physiology; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome
D003062:Codon; D015345:Oligonucleotide Probes