Antioxidant activity of probucol. Short communication.
To evaluate a possible antioxidant activity of probucol on NADPH-dependent microsomal lipid peroxidation and on iron-doxorubicin (adriamycin) complex-induced phospholipid peroxidation, the effects were compared with another powerful antioxidant, 2-OH-estrone. Antioxidant activity of 10 mumol/l probucol in NADPH-dependent microsomal lipid peroxidation corresponded to 4 mumol/l 2-OH-estrone. Together with the results obtained from iron-doxorubicin complex-induced phospholipid peroxidation, it was concluded that probucol is a potent inhibitor of lipid peroxidation and has one-quarter to one-half the antioxidant activity of 2-OH-estrone in vitro.
Minakami
H
H
College of Medical Care and Technology, Gunma University, Japan.
Sotomatsu
A
A
Ohma
C
C
Nakano
M
M
D000818:Animals; D000975:Antioxidants; D004317:Doxorubicin / Q000494:pharmacology; D004970:Estrone / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011341:Probucol / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010636:Phenols; D010743:Phospholipids; D004970:Estrone; D008315:Malondialdehyde; D009249:NADP; D004317:Doxorubicin; D011341:Probucol