title: The effect of microinjections of clonidine into the locus coeruleus on cortical EEG in rats.
abstract: Microinjections of clonidine into the locus coeruleus (LC) area synchronized rat cortical EEG. This effect of clonidine was attenuated by local pretreatment of rats with idazoxan, an alpha-2 adrenoceptor antagonist. The data indicate functional role of alpha-2 adrenoceptors within LC area in regulation of ceruleocortical activity, and point at the LC as one of brain targets for the sedative action of clonidine.
authors.affiliation: Department of Pharmacology and Physiology, Institute of Psychiatry and Neurology, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Danysz
authors.forename: W
authors.initials: W
authors.lastname: Dyr
authors.forename: A
authors.initials: A
authors.lastname: Płaznik
authors.forename: W
authors.initials: W
authors.lastname: Kostowski
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004146:Dioxanes / Q000008:administration & dosage / Q000494:pharmacology; D004569:Electroencephalography; D019329:Idazoxan; D008125:Locus Coeruleus / Q000033:anatomy & histology; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004146:Dioxanes; D003000:Clonidine; D019329:Idazoxan