Role of PAF in ischemia-reperfusion injury in the rat stomach.
Ischemia-reperfusion induced extensive gastric mucosal injury and an increase in chemiluminescence activity of neutrophils obtained from the portal vein in hemorrhagic shock rats. CV-3988, a selective antagonist of platelet activating factor (PAF), significantly reduced the gross and histologic gastric damage, and the increase in chemiluminescence activity of neutrophils. These results suggest that PAF generated on hypoxia might stimulate oxygen radical production by neutrophils, resulting in the occurrence of gastric injury in hemorrhagic shock rats.
Iwai
A
A
First Department of Internal Medicine, Nagoya City University Medical School Japan.
Itoh
M
M
Yokoyama
Y
Y
Yasue
N
N
Miyamoto
T
T
Joh
T
T
Matsusako
K
K
Endoh
K
K
Kawai
T
T
Takeuchi
T
T
D000818:Animals; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000502:physiology; D010742:Phospholipid Ethers / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000503:physiopathology*; D013270:Stomach / Q000503:physiopathology*
D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; C037913:CV 3988