title: [Allergenic impurities in medicinal preparations containing aminopenicillin. I. Ampicillin sodium].
abstract: High-performance liquid chromatography (HPLC) with gradient elution has been used for the determination of degradation products in pharmaceutical preparations containing sodium ampicillin. In all preparations resulting by lyophilization process, the degradation products amount, almost exclusively constituted of allergenic polymeric substances deriving from condensation reactions, is more than 10%. On the contrary, the sodium ampicillin prepared by precipitation in non aqueous solvents, only contains the 2% of polymeric impurities.
authors.forename: P
authors.initials: P
authors.lastname: Betto
authors.forename: L
authors.initials: L
authors.lastname: Turchetto
authors.forename: L
authors.initials: L
authors.lastname: Longinotti
mesh_terms: D000485:Allergens / Q000032:analysis*; D000667:Ampicillin / Q000032:analysis* / Q000592:standards; D011232:Chemical Precipitation; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D004340:Drug Contamination; D005612:Freeze Drying; D011108:Polymers
chemical_list: D000485:Allergens; D011108:Polymers; D000667:Ampicillin
vernacular_title: Impurezze allergogene in specialità medicinali contenenti amino-penicilline. I. Ampicillina sodica.