title: [Aortic wall injury and thrombogenesis in catheterization: experimental study].
abstract: Arterial and venous catheterization is a very useful procedure in the diagnosis of heart diseases. However, some complications with thrombogenesis have been reported. Two kinds of Mikaelson-type non-heparin-coated angiographic catheters (with 6.5 Fr. and 80 cm length) were used for the experiments. One was of polyurethane (PUC) and the other of polyethelene (PEC). Eight experimental dogs were used for each group. The catheter was inserted into the ascending aorta through the femoral artery. No antithrombogenic drugs were given to the animal. One hour later, sodium heparin (100 U/kg) was administered intravenously. The animal was sacrificed by acute exanguination. The aorta was opened longitudinally. The position of the thrombi on the aortic wall was macroscopically observed and the weight of the thrombi attached to the catheters were measured. A piece of the aorta at each level was excised for light and scanning electron microscopic observations. Mural thrombi of various lengths still remained on the aortic wall of every dog after the removal of the catheters. Microscopic observation revealed that the mural thrombus was formed on the aortic wall, where the endothelial cells had peeled off and the internal elastic membrane was partially destroyed. SEM observation also showed that fibrin network on the aortic wall where the endotherial cells were peeled off. Microscopic observation of aortic wall also revealed intimal tears, inner elastic membrane injury and bleeding in the elastic membrane. This damage could worsen leading to dissection of the aorta, thrombosis of the abdominal organs. The injury is considered due to mechanical irriation by the catheter.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: Y
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: T
authors.initials: T
authors.lastname: Okoshi
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: R
authors.initials: R
authors.lastname: Seino
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
authors.forename: Y
authors.initials: Y
authors.lastname: Noishiki
mesh_terms: D000818:Animals; D001011:Aorta / Q000293:injuries*; D006328:Cardiac Catheterization / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D008297:Male; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology