title: A highly divergent HIV-2-related isolate.
abstract: It has been suggested that the human immunodeficiency virus type 2 (HIV-2) and the simian immunodeficiency virus from rhesus macaques (SIVmac) evolved from the sooty mangabey virus SIVsm (ref. 1). We now describe an HIV-2-related isolate, HIV-2-D205, from a healthy Ghanaian woman that is genetically equidistant to the prototypic HIV-2 strains and to SIVsm and SIVmac. Supported by the observation that HIV-2D205 differs in a step of envelope glycoprotein processing, our data indicate that it could represent an alternative HIV-2 subtype and that viruses of the HIV-2/SIVsm/SIVmac group could have already infected humans before HIV-2 and SIVsm/SIVmac diverged.
authors.affiliation: Chemotherapeutisches Forschungsinstitut, Georg-Speyer-Haus, Frankfurt, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Dietrich
authors.forename: M
authors.initials: M
authors.lastname: Adamski
authors.forename: R
authors.initials: R
authors.lastname: Kreutz
authors.forename: A
authors.initials: A
authors.lastname: Seipp
authors.forename: H
authors.initials: H
authors.lastname: Kühnel
authors.forename: H
authors.initials: H
authors.lastname: Rübsamen-Waigmann
mesh_terms: D001483:Base Sequence; D005075:Biological Evolution; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005814:Genes, Viral; D014644:Genetic Variation; D005869:Ghana; D015498:HIV-2 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D015302:Simian Immunodeficiency Virus / Q000145:classification / Q000235:genetics; D014764:Viral Proteins / Q000302:isolation & purification
chemical_list: D014764:Viral Proteins