Reduced responsiveness of bronchoalveolar cells from sensitised guinea-pigs to the cyclic AMP--stimulating effect of prostaglandin E2 and beta-adrenoceptor agonists.
Prostaglandin E2 and the beta-adrenoceptor agonist salbutamol were less effective in increasing the intracellular cAMP content of bronchoalveolar cells and adherent alveolar macrophages from ovalbumin-sensitised as compared to control guinea-pigs. This refractoriness to the cyclic AMP-stimulating effects of PGE2 and salbutamol induced by the sensitisation procedure may be relevant to the altered bronchopulmonary responsiveness in asthma.
Bachelet
M
M
Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM 285, Paris, France.
Masliah
J
J
Malanchere
E
E
Lefort
J
J
Bereziat
G
G
Vargaftig
B B
BB
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D000242:Cyclic AMP / Q000096:biosynthesis*; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D010047:Ovalbumin; D000242:Cyclic AMP; D015232:Dinoprostone; D000420:Albuterol