NAD synthesis and ADPR transferase activity in blood lymphocytes of patients suffering from rheumatoid arthritis and of control persons.
NAD acts not only as a coenzyme in oxidation-reduction processes but also as substrate for adenoribosylation of different proteins. Patients suffering from rheumatoid arthritis show a disturbance in their tryptophan metabolism. Since tryptophan represents a precursor of NAD we turned our attention to the activity of the ADPR transferase, being the enzyme of adenoribosylation, as well as to the synthesis of NAD derived from nicotinamide in human lymphocytes. Lymphocytes of patients with rheumatoid arthritis did not show any differences in their activities as compared with those of control persons, regardless of different measures applied to the patients.
Wohlert
H
H
Robert Kach-Institut, Berlin, West Germany.
Kröger
H
H
Sörensen
H
H
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D009243:NAD / Q000096:biosynthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009243:NAD; D000246:Adenosine Diphosphate Ribose