title: Comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: a European multicentre study.
abstract: The therapeutic effectiveness and safety of indenolol, a vasodilating beta-blocker with beta 2-agonism, was compared with that of atenolol, a cardioselective beta-blocker, in a 1-year double-blind trial. A total of 143 hypertensive patients (diastolic blood pressure 95-115 mmHg after 1 month of placebo) were randomly allocated to either atenolol, 50 mg/day, or indenolol, 60 mg/day. If the target diastolic blood pressure (less than or equal to 90 mmHg) was not reached after 1 month, the beta-blocker was doubled. If the target was still not reached, a diuretic was added after 2 months and doubled after 4 months. There was a higher overall responsiveness and monotherapy was more effective in the atenolol group, but at the lower dose indenolol was more effective than atenolol; however, no differences between drugs were significant. Although the drop-out rate was higher with indenolol, withdrawals due to side effects were similar in both groups. Indenolol was as effective and safe as atenolol in long-term antihypertensive therapy.
authors.affiliation: University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ambrosioni
authors.forename: W
authors.initials: W
authors.lastname: Birkenhäger
authors.forename: P W
authors.initials: PW
authors.lastname: De Leeuw
authors.forename: C
authors.initials: C
authors.lastname: Dal Palù
authors.forename: J C
authors.initials: JC
authors.lastname: Demanet
authors.forename: G
authors.initials: G
authors.lastname: Groothold
authors.forename: A
authors.initials: A
authors.lastname: Libretti
authors.forename: F
authors.initials: F
authors.lastname: Mailland
authors.forename: E
authors.initials: E
authors.lastname: Malacco
authors.forename: A
authors.initials: A
authors.lastname: Poli
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D005060:Europe; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007192:Indenes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011412:Propanolamines / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D007192:Indenes; D011412:Propanolamines; D014665:Vasodilator Agents; D001262:Atenolol; C002989:indenolol