APB increases apparent coupling between horizontal cells in mudpuppy retina.
2-Amino-4-phosphonobutyrate (APB), an agonist at a unique type of glutamate receptor on depolarizing bipolar cells, caused an apparent increase in coupling between horizontal cells as evidenced by a decrease in amplitude of responses to illumination of the receptive field center and an increase in responses to illumination of the peripheral part of the receptive field. APB also caused a hyperpolarization of horizontal cells in darkness and increased the amplitude of responses to full-field illumination, which cannot be explained by an increase in electrical coupling between horizontal cells. Possible mechanisms for these actions are discussed.
Dong
C J
CJ
Department of Physiology, University of Michigan, Ann Arbor 48109-0622.
McReynolds
J S
JS
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D066298:In Vitro Techniques; D008027:Light; D008564:Membrane Potentials / Q000502:physiology; D009338:Necturus maculosus; D010775:Photic Stimulation; D012160:Retina / Q000166:cytology / Q000502:physiology*
D000613:Aminobutyrates; C012729:2-amino-4-phosphonobutyric acid