Plasma-polymerized membrane electrode for the determination of dextromethorphan and dimemorfan.
Ion-selective electrodes (ISEs) responsive to the antitussives dextromethorphan and dimemorfan were constructed by the fixation of an ion-exchanger, ammonium tetraphenylborate, on a Millipore membrane by means of a plasma-polymerization technique. The electrodes showed a Nernstian response over the range of 10(-5)-10(-2) M dextromethorphan and dimemorphan, and the working pH range was 5-7. The interference from common cations such as Na+, K+ and Ca2+ was negligible but some organic cations interfered weakly. The electrodes were applied successfully for the determination of the drugs in pharmaceutical preparations.
Hazemoto
N
N
Ishizaka
S
S
Haga
M
M
Kato
Y
Y
Kurosawa
S
S
Kamo
N
N
Kobatake
Y
Y
D003915:Dextromethorphan / Q000032:analysis*; D004566:Electrodes; D007981:Levorphanol / Q000031:analogs & derivatives*; D008564:Membrane Potentials; D009019:Morphinans / Q000032:analysis*
D009019:Morphinans; D007981:Levorphanol; C012621:dimemorfan; D003915:Dextromethorphan