title: Acetylcholine-induced currents at plasma membrane of the frog oocyte.
abstract: Although with remarkable variability, membrane permeability in Rana oocytes can be modified by application of acetylcholine. The experiments were carried out in voltage-clamp conditions. Like in Xenopus, the responses proved to be related to activation of muscarinic receptors operating membrane channels probably selective for Cl-. At differences with Xenopus, the net acetylcholine-induced current showed remarkable deviation from linearity, displaying outward-going rectification. Application of acetylcholine typically produced opening of membrane channels, while in late spring, we observed the opposite effect in several batches of oocytes.
authors.forename: M
authors.initials: M
authors.lastname: Toselli
authors.forename: L
authors.initials: L
authors.lastname: Simoncini
authors.forename: V
authors.initials: V
authors.lastname: Taglietti
authors.forename: F
authors.initials: F
authors.lastname: Tanzi
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002712:Chlorides / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects*; D009865:Oocytes / Q000032:analysis / Q000187:drug effects*; D011893:Rana esculenta; D011976:Receptors, Muscarinic / Q000032:analysis / Q000187:drug effects
chemical_list: D002712:Chlorides; D007473:Ion Channels; D011976:Receptors, Muscarinic; D000109:Acetylcholine