title: Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.
abstract: We report a case of ibuprofen-induced meningitis in an otherwise healthy individual. This is the 1st case documenting intrathecal IgG synthesis and immune complex formation in this disorder. The immunopathogenesis remains obscure, but is suggestive of an antigen-specific process requiring the presence of or exposure to ibuprofen.
authors.affiliation: Department of Neurology, Cleveland Clinic Foundation, OH 44195.
authors.forename: M
authors.initials: M
authors.lastname: Chez
authors.forename: C A
authors.initials: CA
authors.lastname: Sila
authors.forename: R M
authors.initials: RM
authors.lastname: Ransohoff
authors.forename: D L
authors.initials: DL
authors.lastname: Longworth
authors.forename: C
authors.initials: C
authors.lastname: Weida
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000032:analysis / Q000166:cytology; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D008581:Meningitis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D009422:Nervous System Diseases / Q000188:drug therapy; D010400:Penicillin G / Q000627:therapeutic use; D013126:Spinal Nerve Roots
chemical_list: D007074:Immunoglobulin G; D010400:Penicillin G; D007052:Ibuprofen