title: Iron overload and the predisposition of cells to antioxidant consumption and peroxidative damage.
abstract: We have investigated the effects of iron overload in vivo on the tocopherol levels and the extent of lipid peroxidation in rat liver microsomes and their response to subsequent oxidative stress in vitro. The results demonstrate a direct correlation between consumption of antioxidant defences and the induction and extent of malondialdehyde production in microsomes prepared from iron-loaded rats. The data are consistent with the requirement for iron (II)/iron (III) ratios in lipid peroxidation in control microsomes.
authors.affiliation: Department of Biochemistry, Royal Free Hospital and school of Medicine, London.
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
authors.forename: P
authors.initials: P
authors.lastname: McCarthy
authors.forename: T
authors.initials: T
authors.lastname: Hallinan
authors.forename: N A
authors.initials: NA
authors.lastname: Green
authors.forename: J
authors.initials: J
authors.lastname: Gor
authors.forename: A T
authors.initials: AT
authors.lastname: Diplock
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D007501:Iron / Q000506:poisoning*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008956:Models, Chemical; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D007501:Iron