[A case of recurrent multiple cerebral infarctions with protein C abnormality].
A 38-year-old man of recurrent episodes of multiple cerebral infarctions with protein C abnormality was reported. He had six episodes of visual disturbance within a year. The neurological examination revealed bilateral visual loss and impaired visual field except for small central area. However, there were no abnormalities in the deep tendon reflexes and muscle strength of all extremities and cerebellar examinations. CT scan revealed multiple low density areas in the bilateral posterior lobes, and cerebral angiography demonstrated the severe stenosis of the ganglionic portion and the supraclinoid portion of the right internal carotid artery. Plasma levels of antithrombin-III activity, plasminogen activity, protein C activity, protein C antigen and protein S antigen were 105, 106, 28, 166 and 120%, respectively. Because only protein C activity decreased markedly, a diagnosis of protein C abnormality was established. We started warfarin therapy under the administration of concentrates of factor IX complex, since then there has been no cerebral accident.
Sasaki
M
M
Tokonami
F
F
Tsuji
S
S
Murai
Y
Y
Shirahata
S
S
D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002544:Cerebral Infarction / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D020151:Protein C Deficiency; D012008:Recurrence; D014859:Warfarin / Q000627:therapeutic use
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D014859:Warfarin