title: Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons.
abstract: Suicide transport of the toxic lectin, ricin, by hypoglossal and vagus neurons resulted in motor neuron loss in the associated nuclei, and reduced the binding of the 125I-Bolton-Hunter labeled substance P in the same nuclei. These data show that substance P receptors are located on the cell bodies of medullary somatic and preganglionic motor neurons of the hypoglossal and vagus nerves, and that suicide transport is a useful technique to determine the cellular localization of binding sites within a nucleus.
authors.forename: C J
authors.initials: CJ
authors.lastname: Helke
authors.forename: C G
authors.initials: CG
authors.lastname: Charlton
authors.forename: R G
authors.initials: RG
authors.lastname: Wiley
mesh_terms: D000818:Animals; D001370:Axonal Transport; D002470:Cell Survival; D007002:Hypoglossal Nerve / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012276:Ricin / Q000378:metabolism* / Q000494:pharmacology; D013373:Substance P / Q000378:metabolism; D014630:Vagus Nerve / Q000378:metabolism*
chemical_list: D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P; D012276:Ricin