Neurotrophic action of autopsied ventral spinal cord extracts in patients with amyotrophic lateral sclerosis on the ventral spinal cord of rat embryo.
The effects of ventral spinal cord extracts from normal controls and patients with amyotrophic lateral sclerosis (ALS) on neurite appearance in ventral spinal cord explant of 13-day-old Sprague-Dawley rats were investigated. Ventral spinal cord extracts from normal controls and ALS were significantly more effective in stimulating growth than control medium only. There was no statistically significant difference between normal and ALS ventral spinal cord extracts in growth of neurites. Our results may be an important for the consideration of the hypothesis that ALS may be a disorder of motor neuron growth factors.
Iwasaki
Y
Y
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Kinoshita
M
M
Ikeda
K
K
Shiojima
T
T
D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D004622:Embryo, Mammalian; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014020:Tissue Extracts / Q000494:pharmacology*
D009414:Nerve Growth Factors; D014020:Tissue Extracts