A multipoint linkage map around the locus for myotonic dystrophy on chromosome 19.
Employing 16 polymorphic DNA markers as well as the chromosome 19 centromere heteromorphism, we have performed a genetic linkage study in 26 families with myotonic dystrophy. Fourteen of these markers had been assigned previously to one of five different intervals of the 19cen-19q13.2 segment by using somatic cell hybrids. For the long arm of chromosome 19, a genetic map that encompasses 9 polymorphic markers and the DM gene has been constructed. Our studies indicate that the DM and CKMM genes map distal to the ApoC2-ApoE gene cluster and to the anonymous polymorphic markers D19S15 and D19S16, but proximal to the D19S22 marker. The orientation of DM and CKMM remains to be determined.
Brunner
H G
HG
Department of Human Genetics, University Hospital, 6500HB Nijmegen, The Netherlands.
Smeets
H
H
Lambermon
H M
HM
Coerwinkel-Driessen
M
M
van Oost
B A
BA
Wieringa
B
B
Ropers
H H
HH
D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003434:Crossing Over, Genetic; D004252:DNA Mutational Analysis; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
D005819:Genetic Markers