Effect of hyperthermia on lymphocyte plasma membrane. 3 electrolyte spin labels permeability.
The effect of elevated temperatures on the transport of electrolyte spin labels anionic c-TEMPIR and cationic TEMPO-choline character across the porcine lymphocyte plasma membrane was investigated. Breaks in the Arrhenius plot for permeability of both spin-labels occurred at 42 to 43 degrees C. TEMPO-choline and c-TEMPIR transport are probably critical targets in hyperthermic cell killing.
Koter
M
M
Department of Biophysics, University of Lódź, Poland.
D000818:Animals; D002463:Cell Membrane Permeability; D003497:Cyclic N-Oxides / Q000493:pharmacokinetics*; D005334:Fever / Q000503:physiopathology*; D008214:Lymphocytes / Q000502:physiology*; D013552:Swine
D003497:Cyclic N-Oxides; C032289:2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid; C017743:tempocholine