title: Postanesthetic equine myopathy suggestive of malignant hyperthermia. A case report.
abstract: Signs of malignant hyperthermia, including progressive increases in PaCO2, skin temperature and heart rate, and elevated serum levels of potassium, inorganic phosphate, and creatine kinase, were identified in a halothane-anesthetized horse. Treatment was discontinuing halothane administration, applying ice and cold fluids, and hyperventilating with 100% oxygen. After an initial recovery, bilateral hindlimb myopathy and pigmenturia developed. The myopathy resolved after treatment with oral dantrolene, IV fluids, and hydrocortisone. Results of caffeine-halothane challenge, using semimembranosus muscle collected 2 weeks after the episode, were considered within normal limits for horses. The intraoperative abnormalities were evidently predictive of postanesthetic myopathy but the cause in this horse remained unclear.
authors.affiliation: Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center 19348.
authors.forename: L
authors.initials: L
authors.lastname: Klein
authors.forename: N
authors.initials: N
authors.lastname: Ailes
authors.forename: G E
authors.initials: GE
authors.lastname: Fackelman
authors.forename: E
authors.initials: E
authors.lastname: Kellon
authors.forename: H
authors.initials: H
authors.lastname: Rosenberg
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D005260:Female; D006221:Halothane; D006734:Horse Diseases / Q000209:etiology*; D006736:Horses; D008305:Malignant Hyperthermia / Q000209:etiology / Q000662:veterinary*; D009135:Muscular Diseases / Q000209:etiology / Q000662:veterinary*
chemical_list: D006221:Halothane