title: Pharmacokinetic study of orally administered RU 486 in non-pregnant women.
abstract: A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (mean t1/2 alpha: 1.4h), whereas elimination was slow (mean t1/2 beta: 28.3 h). RU 486 was still detectable in some women at 72 h after administration. The plasma concentrations fitted the equation for a two-compartment open model from which the pharmacokinetic parameters were calculated. The mean total plasma clearance was 3.0 l/h, and the comparison of our data with those published studies suggests that the pharmacokinetics of RU 486 in Chinese women are similar to those of other populations.
authors.affiliation: Shanghai Institute of Planned Parenthood Research, People's Republic of China.
authors.forename: C H
authors.initials: CH
authors.lastname: He
authors.forename: Y E
authors.initials: YE
authors.lastname: Shi
authors.forename: Z H
authors.initials: ZH
authors.lastname: Ye
authors.forename: G G
authors.initials: GG
authors.lastname: Zhang
authors.forename: N X
authors.initials: NX
authors.lastname: Jiang
authors.forename: P F
authors.initials: PF
authors.lastname: Van Look
authors.forename: K
authors.initials: K
authors.lastname: Fotherby
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D015735:Mifepristone