Anticomplementary activity of dextran derivatives.
Substitution with carboxylic and benzylamine sulphonated groups conferred on dextran both antithrombic activity and the capacity to inhibit formation of the amplification C3 convertase of complement. In dextrans substituted with carboxylic groups (greater than 40%), a high content of sulphonate (greater than 10%) resulted in both anticomplementary and antithrombic properties whereas a lower content of sulphonate resulted in high anticomplementary but weak antithrombic activity. The anticomplementary activity of highly substituted dextrans was similar to that of heparin, although anticoagulant activity was much lower than in heparin, confirming independent structural requirements for both activities in the heparin molecule.
Mauzac
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Maillet
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Jozefonvicz
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Kazatchkine
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D050577:Complement C3-C5 Convertases / Q000037:antagonists & inhibitors; D003169:Complement Inactivator Proteins; D003911:Dextrans / Q000494:pharmacology*; D005343:Fibrinolytic Agents; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques
D003169:Complement Inactivator Proteins; D003911:Dextrans; D005343:Fibrinolytic Agents; D006493:Heparin; D050577:Complement C3-C5 Convertases