title: Comparative in-vitro activity of twenty antimicrobial agents against clinical isolates of Mycobacterium avium complex.
abstract: The in-vitro susceptibility of Mycobacterium avium complex isolates, obtained from immunosuppressed patients with and without the Acquired Immunodeficiency Syndrome (AIDS), to various antimicrobial agents was determined. Amikacin, the 4-quinolone compounds--ciprofloxacin, temafloxacin and PD 117558--and the penem SCH 34343 were active against most of the isolates. In-vitro synergism using selected antimicrobial combinations could not be demonstrated. No differences in the susceptibility, depending upon the source of the isolates (AIDS or non-AIDS), were noted.
authors.affiliation: Department of Medical Specialities, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: N
authors.initials: N
authors.lastname: Khardori
authors.forename: K
authors.initials: K
authors.lastname: Rolston
authors.forename: B
authors.initials: B
authors.lastname: Rosenbaum
authors.forename: S
authors.initials: S
authors.lastname: Hayat
authors.forename: G P
authors.initials: GP
authors.lastname: Bodey
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003470:Culture Media; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media