title: Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells.
abstract: In mediating the entry of adenosine into mouse erythrocytes and mouse leukaemia L1210 cells, nucleoside transport systems were stereoselective, showing a marked preference for the D-enantiomer of adenosine (D-Ado). Inward zero-trans fluxes of the mirror-image isomer, L-adenosine (L-Ado), in those cells were slow relative to those of D-Ado. Contributing to L-Ado fluxes in both cell types were (i) a transporter-mediated process of high nitrobenzylthioinosine-sensitivity and (ii) simple diffusion.
authors.affiliation: Department of Pharmacology, University of Alberta, Edmonton, Canada.
authors.forename: W P
authors.initials: WP
authors.lastname: Gati
authors.forename: L
authors.initials: L
authors.lastname: Dagnino
authors.forename: A R
authors.initials: AR
authors.lastname: Paterson
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D012964:Sodium / Q000378:metabolism; D013237:Stereoisomerism; D013868:Thioinosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D013868:Thioinosine; D012964:Sodium; C001789:4-nitrobenzylthioinosine; D000241:Adenosine