Axons of passage may be responsible for fastigial nucleus pressor response.
Bilateral destruction of perikarya in the fastigial nucleus (FN) of the rat with the cytotoxic agent kainic acid (0.5 mg) did not alter the blood pressure (BP) increases observed during monopolar electrical stimulation (100 microA, 50 Hz, 0.5-ms pulse width) of this region. BP increases in control animals were 30 +/- 8 mm Hg, whereas BP increased 30 +/- 7 mmHg in kainic acid-lesioned rats. Furthermore, picrotoxin (100 ng) and muscimol (25 ng) microinjected unilaterally into the FN of conscious, unrestrained rats produced postural asymmetry but no change in BP or heart rate. These data suggest that the FN pressor response may be due, at least in part, to stimulation of axons of passage.
Henry
R T
RT
Department of Pharmacology, University of California, San Diego, La Jolla 92093.
Connor
J D
JD
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D002529:Cerebellar Nuclei / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology*; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D007608:Kainic Acid; D009118:Muscimol; D010852:Picrotoxin