The effects of type-1 and type-2 diabetes on endothelium-dependent relaxation in rat aorta.
Diabetes mellitus is known to produce alterations in vascular reactivity. In the present study we have examined the effects of endothelium-dependent and endothelium-independent relaxing substances on thoracic aorta from insulin-dependent (Type-1) and noninsulin-dependent (Type-2) diabetic rats and their appropriate controls. Endothelium-dependent relaxations produced by acetylcholine and histamine in aortic rings precontracted with noradrenaline were significantly increased in insulin-dependent diabetic vessels. In contrast, the relaxations elicited by those agents were significantly attenuated in noninsulin-dependent diabetic aorta preparations. On the other hand, the relaxations induced by sodium nitroprusside (an endothelium-independent relaxant agent) in both types of diabetic preparations were comparable to those in control vessels. The results indicate that insulin-dependent and noninsulin-dependent diabetes lead to specific alterations of the endothelium-dependent relaxation of rat aorta.
Altan
V M
VM
Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.
Karasu
C
C
Ozüari
A
A
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005292:Ferricyanides / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology*; D051381:Rats; D014664:Vasodilation / Q000187:drug effects
D005292:Ferricyanides; D009599:Nitroprusside; D006632:Histamine; D000109:Acetylcholine