[Prediction of radiosensitivity by DNA analysis].
The aim of the study is to investigate the relationship between DNA histogram and radiosensitivity on tumor specimens taken directly from patients. Flow cytometric DNA content analysis with PI (Propidium iodide) was performed on specimens of cervical carcinoma. Radiosensitivities of respective tumors were determined on biopsy specimens that were taken 3 weeks after the start of radiotherapy. Five parameters (over 4C, %G2M, %S, PI, DI) were calculated from DNA Histogram. Among these parameters over 4C, %G2M and PI correlated well to radiosensitivity.
Kubota
S
S
Dept. of Hospital, National Institute of Radiational Sciences.
Sato
S
S
Nakano
T
T
Morita
S
S
Tunemoto
H
H
Ando
K
K
Sekiya
T
T
Sugishita
T
T
D000328:Adult; D000368:Aged; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011836:Radiation Tolerance; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000473:pathology / Q000532:radiotherapy*
D004273:DNA, Neoplasm