title: [Selective accumulation of 147Pm in organism on induction of micronucleus and SCE of bone marrow cells as well as the mutagenic effect on fetal liver and spleen].
abstract: Study of accumulation peculiarity of 147Pm showed that iv. different doses of 147Pm were the same selectively localized in skeleton. Retention of 147Pm in skeleton was elevated when the radioactive doses of 147Pm were increased. At the same time absorption dose of 147Pm radiation was also raised. The ability of 147Pm to induce sister chromatid exchanges (SCEs) has been investigated by IdU labelling methods. A statistically significant elevation of SCEs was observed after 147Pm intake. The number of SCEs per cell in bone marrow cells was always higher in mice when the animals were maintained on the doses of 37 Bq/g. We observed the injurious effects of 147Pm, using micronucleus rates in bone marrow cells as indicator. The results showed that the lower limit of injected activity effecting marked rise of rates was 185 Bq/g A peak rate of 1.34% was reached at 24 here after intake of 147Pm 1.85 x 10(5) Bq/g. Our study is also to ascertain the correlation between maternal deposition, perinatal uptake of 147Pm and their chromosome aberrations of maternal and fetal liver cells. Results indicated that 147Pm was predominantly deposited in maternal liver. Deposition of 147Pm in maternal spleen was about one quarter of that in the maternal liver. In view of the placental barrier uptake of 147Pm by fetal liver or spleen was definitely depressed. Studies indicated that maternal contamination of 147Pm could induce chromosome aberrations in fetal liver and spleen cells. Among the type of aberrations induced by 147Pm, chromatid breakage were predominant.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: S P
authors.initials: SP
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D002869:Chromosome Aberrations; D005333:Fetus; D008099:Liver / Q000528:radiation effects; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D011399:Promethium / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000528:radiation effects*; D013154:Spleen / Q000528:radiation effects
chemical_list: D011399:Promethium