title: Effects of pinealectomy on regional brain serotonin metabolism.
abstract: The influence of pinealectomy on serotonin cerebral metabolism was examined in male rats maintained in a long photoperiod (14 h L:10 h D). Eight weeks after pinealectomy, serum, hepatic and CNS concentrations of tryptophan were not affected. The concentrations of 5-HT was significantly decreased in only three regions, hypothalamus, midbrain and hippocampus. The levels of 5-HIAA decreased significantly only in the hypothalamus and the midbrain. These results suggest that pinealectomy promotes a decreased hypothalamic and midbrain 5-HT utilization.
authors.forename: M
authors.initials: M
authors.lastname: Aldegunde
authors.forename: I
authors.initials: I
authors.lastname: Miguez
authors.forename: J
authors.initials: J
authors.lastname: Veira
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan