MHC-linked immune response suppression mediated by T cells bearing I-A-encoded determinants.
The immune response to chicken egg-white lysozyme (HEL) is actively and specifically regulated by antigen-specific T cell-mediated suppression in mice bearing the H-2b haplotype; the suppression is therefore MHC-linked. In this report, we propose a possible mechanism for MHC-linked suppression of HEL-helper T cells based on expression of I region-encoded cell surface determinants. We determined whether inhibition of anti-HEL antibody responses correlated with expression of serologically detectable I-A-encoded cell surface determinants by antigen-specific helper, suppressor-inducer, or suppressor-effector T cells. It was observed that HEL-suppressor-effector T cells, but not helper or suppressor-inducer T cells, were eliminated after treatment with anti-I-Ab antibody and complement. Furthermore, suppressor-effector T cells co-express Thy-1, Lyt-2, and I-A cell surface antigens. These results raise the possibility that HEL-specific helper T cells become functionally inhibited after recognition of HEL and I-A alloantigen displayed by suppressor-effector T cells. Thus, the interaction between helper and suppressor T cells may be analogous to the mechanism of T cell-B cell interaction.
Araneo
B A
BA
Yowell
R L
RL
D000818:Animals; D000917:Antibody Formation; D000950:Antigens, Ly; D000954:Antigens, Surface; D002645:Chickens; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009113:Muramidase / Q000276:immunology; D010641:Phenotype; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000145:classification* / Q000276:immunology; D018800:Thy-1 Antigens
D000950:Antigens, Ly; D000954:Antigens, Surface; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D018800:Thy-1 Antigens; D009113:Muramidase