Lesions of the anteroventral third ventricle prevent salt-induced hypertension in the borderline hypertensive rat.
Many forms of experimental hypertension depend on the integrity of the periventricular tissue surrounding the anteroventral third ventricle. The current investigation examined the extent to which this forebrain area is necessary for the elaboration of salt-induced hypertension in the borderline hypertensive rat. Eight-week-old male rats were given either electrolytic lesions of the anteroventral portion of the third ventricle region or sham lesions. All rats were then placed on a high salt diet (8% NaCl) for 10 weeks. At the conclusion of this dietary period, direct measurement of resting mean arterial pressure revealed that borderline hypertensive rats with lesions of the anteroventral portion of the third ventricle had significantly lower blood pressure (128.4 +/- 5.1 mm Hg) compared with sham-operated rats (148.1 +/- 4.1 mm Hg).
Sanders
B J
BJ
Department of Psychology, University of Iowa, Iowa City 52242.
Johnson
A K
AK
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D002552:Cerebral Ventricles / Q000293:injuries*; D003433:Crosses, Genetic; D006706:Homeostasis; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012982:Sodium, Dietary / Q000009:adverse effects; D013312:Stress, Physiological
D012982:Sodium, Dietary