Determination of pipothiazine in human plasma by reversed-phase high-performance liquid chromatography.
A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely to be taken concurrently by patients were tested for potential to interfere with the assay. There was no evidence of "dose-dumping" in the period following injection. Comparison of the pharmacokinetic profiles after the first and sixth injections showed no evidence of drug accumulation.
Ogden
D A
DA
Department of Pharmacy, Heriot-Watt University, Edinburgh, UK.
McKechnie
A A
AA
Bolton
D A
DA
Rankin
R B
RB
Dobbins
S E
SE
Clements
J A
JA
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000097:blood*
D010640:Phenothiazines