title: Anorexic effects of interleukin 1 in the rat.
abstract: Interleukin 1 (IL-1) administration produces anorexia. Among unanswered questions about this effect are 1) whether it plays a role in the cachexia associated with chronic infection and cancer, and 2) whether IL-1 acts directly on food intake or indirectly by first lowering the set point for body weight. To investigate these questions, rats were infused with recombinant IL-1 continuously for 14 days through osmotic minipumps. Tolerance to the anorexic effects of the infusion developed within a few days. Control experiments showed that neither loss of IL-1 potency nor failure in the delivery system were responsible for recovery of food intake. Prior weight reduction completely overrode the anorexic effects of IL-1; previously food-restricted rats were hyperphagic initially despite receiving IL-1. This result is consistent with the view that IL-1 lowers the set point for body weight, but the development of tolerance prevented the full evaluation of this interpretation.
authors.affiliation: Department of Zoology, University of Toronto, Ontario, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Mrosovsky
authors.forename: L A
authors.initials: LA
authors.lastname: Molony
authors.forename: C A
authors.initials: CA
authors.lastname: Conn
authors.forename: M J
authors.initials: MJ
authors.lastname: Kluger
mesh_terms: D000818:Animals; D001067:Appetite Depressants; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007263:Infusions, Parenteral; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012016:Reference Values
chemical_list: D001067:Appetite Depressants; D007375:Interleukin-1; D011994:Recombinant Proteins