Renin release responses to in vitro prostaglandin challenge in the summer-active ground squirrel, Spermophilus lateralis.
1. Using a renal cortical slice preparation from the summer-active ground squirrel, Spermophilus lateralis, resting renin release (RR) and tissue cyclic AMP content (TcAMPC) levels were found to be significantly higher and lower, respectively, than those previously reported for its hibernating counterpart. 2. At a 10(-5) M dose, PGE2 but not PGE1, PGF2-alpha or PGA1, significantly stimulated RR in the summer-active ground squirrel (SAGS). 3. Addition of agents which normally increase TcAMPC significantly potentiated the effect of PGE1, while preventing that of PGE2, on RR and TcAMPC. 4. Opposite TcAMPC changes may mediate the in vitro RR responses to PGE1 and PGE2 administration in the SAGS.
Lopez
G A
GA
Department of Biology, California State University, Los Angeles 90032.
Lopez
N
N
Brazal
S
S
Natividad
M
M
D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D012083:Renin / Q000378:metabolism*; D012589:Sciuridae / Q000502:physiology*; D012621:Seasons
D011453:Prostaglandins; D011454:Prostaglandins A; D015237:Dinoprost; D000242:Cyclic AMP; D012083:Renin; D000527:Alprostadil; D015232:Dinoprostone; C100573:prostaglandin A1