Sex differences in long-term gonadectomized rats: monoamine levels and [3H]nitroimipramine binding in brain nuclei.
The levels of norepinephrine, dopamine, serotonin and the serotonin metabolite 5-hydroxyindoleacetic acid were measured in microdissected brain nuclei from long-term gonadectomized male and female rats. Females had 50 and 120% higher levels of serotonin in the anterior hypothalamic nucleus (AH) and arcuate-median eminence (AR-ME), respectively. No significant differences in norepinephrine, dopamine or 5-hydroxyindoline acetic acid were found in any of the brain nuclei sampled. The differences in serotonin content do not appear to result from a sexually dimorphic distribution of serotonin nerve terminals since quantitative autoradiography of 3H-nitroimipramine revealed no differences in binding between the sexes in the AH or AR-ME.
Renner
K J
KJ
Biegon
A
A
Luine
V N
VN
D000818:Animals; D001665:Binding Sites; D001679:Biogenic Amines / Q000032:analysis*; D002369:Castration; D004298:Dopamine / Q000032:analysis; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007099:Imipramine / Q000031:analogs & derivatives* / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D012727:Sex Characteristics
D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C030721:2-nitroimipramine; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine