title: Treatment of external pancreatic fistulas with somatostatin. Second place winner: Conrad Jobst award.
abstract: Five patients with external pancreatic fistulas were treated with a synthetic peptide that mimics the action of somatostatin (Sandostatin, Sandoz; East Hanover, NJ). Four of the patients developed fistulas after drainage of pancreatic pseudocysts and one developed a fistula following resection of a pancreatic carcinoid. One day after initiation of therapy, the mean fistula output for the group decreased by 52 per cent. By three days, fistula output decreased by 70 per cent. All fistulas closed in 7 to 44 days. Adverse reactions to the drug included diarrhea in one patient and transient hyperglycemia in another. Sandostatin is effective in decreasing drainage from external pancreatic fistulas and may, therefore, facilitate their closure. No serious adverse reactions to the drug were noted. Further studies will better define the role of Sandostatin in the treatment of pancreatic fistulas.
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, SC 29425.
authors.forename: F T
authors.initials: FT
authors.lastname: Lansden
authors.forename: D B
authors.initials: DB
authors.lastname: Adams
authors.forename: M C
authors.initials: MC
authors.lastname: Anderson
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010185:Pancreatic Fistula / Q000188:drug therapy*; D011446:Prospective Studies; D013004:Somatostatin
chemical_list: D013004:Somatostatin; D015282:Octreotide