title: Somatostatin secretion from isolated rat pancreatic islets.
abstract: Certain aspects of somatostatin secretion from isolated rat pancreatic islets are described. A considerable, but falling basal secretion of somatostatin was observed in the pre-incubation periods. Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose. The glucose effect on somatostatin secretion required a normoglycaemic pre-incubation level of 5.5 mmol l-1 glucose. Our results indicate that somatostatin secretion from isolated pancreatic islets is strongly dependent on the experimental conditions.
authors.affiliation: Department of Medicine, University Hospital of Tromsø, Norway.
authors.forename: B
authors.initials: B
authors.lastname: Vonen
authors.forename: J
authors.initials: J
authors.lastname: Florholmen
authors.forename: A K
authors.initials: AK
authors.lastname: Giaever
authors.forename: P
authors.initials: P
authors.lastname: Burhol
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology
chemical_list: D013004:Somatostatin; D002217:Carbachol; D013806:Theophylline; D005947:Glucose