title: Determination of pipothiazine in human plasma by reversed-phase high-performance liquid chromatography.
abstract: A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely to be taken concurrently by patients were tested for potential to interfere with the assay. There was no evidence of "dose-dumping" in the period following injection. Comparison of the pharmacokinetic profiles after the first and sixth injections showed no evidence of drug accumulation.
authors.affiliation: Department of Pharmacy, Heriot-Watt University, Edinburgh, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Ogden
authors.forename: A A
authors.initials: AA
authors.lastname: McKechnie
authors.forename: D A
authors.initials: DA
authors.lastname: Bolton
authors.forename: R B
authors.initials: RB
authors.lastname: Rankin
authors.forename: S E
authors.initials: SE
authors.lastname: Dobbins
authors.forename: J A
authors.initials: JA
authors.lastname: Clements
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000097:blood*
chemical_list: D010640:Phenothiazines