Family resemblance for glucose tolerance in a Melanesian population, the Tolai.
Path analysis of family resemblance for plasma glucose concentration, 2 h after an oral glucose challenge, failed to detect significant genetic heritability. There were no intergenerational differences and marital resemblance was moderate. Over one-third of sibling environmental similarity was due to non-inherited factors. Cultural inheritance was very strong, tending to mimic genetic inheritance, and cultural heritability was considerable. Measures of obesity were included in the environmental index, an estimate of familial environment, in this analysis, for comparability with previous studies. Since obesity appears, in part, to be a heritable trait, in future studies a bivariate approach to family resemblance for both glucose tolerance and obesity could yield important additional insight.
King
H
H
WHO Collaborating Centre for the Epidemiology of Diabetes mellitus, Lions-International Diabetes Institute, Melbourne, Australia.
Rao
D C
DC
Bhatia
K
K
Koki
G
G
Collins
A
A
Zimmet
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008542:Melanesia / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology / Q000235:genetics; D010641:Phenotype; D012885:Skinfold Thickness
D001786:Blood Glucose