Tumor growth-promoting effect of immunosuppressive substance in mice.
The effect of immunosuppressive (IS) substance obtained from cancerous ascitic fluid on tumor growth and host immunity in plasmacytoma X5563-bearing C3H/He mice is described. IS substance given in three injections, before and after tumor inoculation caused: (a) enhanced tumor growth, (b) marked reduction in survival times, (c) inhibition on Con-A response of spleen cells. Depressed natural killer (NK) activity was observed in normal and tumor-bearing mice treated with IS substance. The data presented here suggest that IS substance suppresses both humoral and cellular immunoresponsiveness and tumor cells evade immune surveillance or immunologically mediated removal.
Fujii
M
M
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
Takahashi
N
N
Fujii
T
T
Hayashi
H
H
Matsunaga
K
K
Furusho
T
T
Omura
Y
Y
Yoshikumi
C
C
D000818:Animals; D002273:Carcinogens; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology*; D010954:Plasmacytoma / Q000473:pathology; D013154:Spleen / Q000276:immunology; D016019:Survival Analysis
D002273:Carcinogens; D007166:Immunosuppressive Agents