title: [The creation of specific immunity to staphylococcal infection in newborn infants by the intranasal administration of adsorbed staphylococcal anatoxin].
abstract: The possibility of enhancing specific immunity in newborn infants by the intranasal administration of adsorbed staphylococcal toxoid to infants with a high risk of staphylococcal infection in doses of 1 drop (0.05 ml) into each nostril during the first 7-9 years of their life. On days 7-9 the level of anti-alpha-toxin in the blood rose to 3.8 +/- 0.14 I. U./ml and remained sufficiently high 3-6 months later. When this method was used for the simultaneous immunization of mothers, their antitoxic titers were not as high as in newborn infants. No side effects were observed. In the control group, the titers of anti-alpha-toxin were low during the whole period of observation. Infants immunized by the proposed method had no staphylococcal infections both during the newborn period and within the first year of their life. In the control group, 8 cases of minor forms of purulent septic infection were registered during the newborn period, and in 2 infants umbilical staphylococcal sepsis was diagnosed.
authors.forename: E P
authors.initials: EP
authors.lastname: Manolova
authors.forename: Z N
authors.initials: ZN
authors.lastname: Tret'iakevich
authors.forename: S V
authors.initials: SV
authors.lastname: Khripko
mesh_terms: D000281:Administration, Intranasal; D000327:Adsorption; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000276:immunology; D001427:Bacterial Toxins / Q000276:immunology; D005260:Female; D006460:Hemolysin Proteins; D006801:Humans; D007114:Immunization / Q000379:methods; D007231:Infant, Newborn; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000276:immunology* / Q000517:prevention & control; D013208:Staphylococcal Toxoid / Q000008:administration & dosage* / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D013208:Staphylococcal Toxoid; C021091:staphylococcal alpha-toxin
vernacular_title: Sozdanie spetsificheskogo immuniteta k stafilokokkovoĭ infektsii u novorozhdennykh deteĭ putem intranazal'nogo vvedeniia adsorbirovannogo stafilokokkovogo anatoksina.