Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.
White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population. The presence of such unusual alleles may be linked to susceptibility to cancer.
Krontiris
T G
TG
DiMartino
N A
NA
Colb
M
M
Parkinson
D R
DR
D000483:Alleles; D002460:Cell Line; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis*; D015245:Deoxyribonuclease BamHI; D019003:Deoxyribonuclease HpaII; D005260:Female; D005838:Genotype; D006801:Humans; D007962:Leukocytes / Q000032:analysis; D009369:Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic
D004273:DNA, Neoplasm; D004247:DNA; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI; D019003:Deoxyribonuclease HpaII