Melanin in the inner ear. An experimental study with control and kanamycin-intoxicated colored guinea-pigs.
Following several studies on the effects of kanamycin toxicity on the inner ears of guinea pigs, we have studied the importance of melanin in this phenomenon. Transmission electron microscopy showed that, under the influence of kanamycin, the intermediate strial cells developed a secretory aspect similar to that seen in skin melanocytes. This aspect as yet has never been described for the inner ear cells. A planimetric, morphometric method was also used to determine the strial cell melanin status in control animals. Additional findings in the study confirmed an increase in the number of melanosomes during kanamycin poisoning. Statistical data are discussed.
Gratacap
B
B
Clinique Universitaire d' ORL, CHU de Grenoble, France.
Attard
A
A
Laurent
A
A
Stoebner
P
P
Smirou
D
D
Charachon
R
R
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D003051:Cochlea; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000473:pathology; D007612:Kanamycin / Q000633:toxicity*; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000187:drug effects; D008854:Microscopy, Electron; D013316:Stria Vascularis / Q000187:drug effects* / Q000473:pathology
D008543:Melanins; D007612:Kanamycin