title: Effect of acute respiratory acidosis on multimodality sensory evoked potentials of Long-Evans rats.
abstract: Auditory, visual and somatosensory evoked potentials (EPs), recorded epidurally from 31 chronically implanted male Long-Evans rats, were studied to examine the pattern of sensory effects caused by hypercapnia. Recordings were obtained before exposures, 10-20 min after the beginning of exposure to CO2 in synthetic air, and 30 min after the end of exposure. Previous recordings revealed no substantial effects of the extended recording period itself. Blood pH during an average exposure of 18.8% CO2 was about 7.1. During this level of CO2 exposure the somatosensory response was almost completely abolished, but the latencies of early detectable components were not affected. In contrast, the latencies of all brainstem auditory evoked response components and the 1-5 interwave time increased, whereas amplitudes were only slightly affected. Amplitudes and latencies of early and late components of the flash EP were decreased and lengthened, but the after-discharge components appeared to be most sensitive to CO2. Concentration-response relationships were examined by exposure of rats to 8 and 16% CO2. The most sensitive EP parameter was average amplitude of the late somatosensory EP components. These results suggest that EPs might be useful for assessing acute metabolic disturbances as well as more commonly assessed neurologic disorders.
authors.affiliation: SRI International, Menlo Park, CA 94025.
authors.forename: C S
authors.initials: CS
authors.lastname: Rebert
authors.forename: E E
authors.initials: EE
authors.lastname: Davis
authors.forename: L T
authors.initials: LT
authors.lastname: Juhos
authors.forename: R A
authors.initials: RA
authors.lastname: Jensen
authors.forename: G T
authors.initials: GT
authors.lastname: Pryor
authors.forename: E D
authors.initials: ED
authors.lastname: Robin
mesh_terms: D000142:Acidosis, Respiratory / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D008297:Male; D051381:Rats; D011930:Reaction Time