Ionic transport across corneal endothelium.
The active potential difference across bovine corneal endothelium was measured in vitro at different temperatures, pH, osmolality and salt compositions. The measurements were made using either identical or different solutions on each side of the membrane. The experimental results are consistent with a model in which sodium is actively transported into the intercellular cleft. We propose that Na+ re-enters the cell electroneutrally by coupled co-transport with carbonate, derived from bicarbonate in the solution.
Lyslo
A
A
Kvernes
S
S
Garlid
K
K
Ratkje
S K
SK
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002417:Cattle; D003315:Cornea / Q000378:metabolism* / Q000502:physiology; D003470:Culture Media; D004727:Endothelium / Q000378:metabolism / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D009994:Osmolar Concentration; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013696:Temperature
D001639:Bicarbonates; D003470:Culture Media; D007473:Ion Channels; D012965:Sodium Chloride; D010042:Ouabain; D012964:Sodium