title: The effect of the secretory leukocyte protease inhibitor on leukocyte proteases released during phagocytosis.
abstract: The human secretory leukocyte protease inhibitor effectively binds and blocks the digestive activity of elastase released from PMN leukocytes during phagocytosis of opsonized yeast particles. About 25% of the alpha 1-protease inhibitor present in the incubation medium is inactivated during the phagocytosis, while the secretory leukocyte protease inhibitor retains more than 90% of its inhibiting capacity.
authors.affiliation: Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Axelsson
authors.forename: C
authors.initials: C
authors.lastname: Linder
authors.forename: K
authors.initials: K
authors.lastname: Ohlsson
authors.forename: M
authors.initials: M
authors.lastname: Rosengren
mesh_terms: D002850:Chromatography, Gel; D003176:Complement C3 / Q000032:analysis; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000201:enzymology*; D009895:Opsonin Proteins / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism*; D010587:Phagocytosis; D011480:Protease Inhibitors / Q000494:pharmacology*; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors
chemical_list: D003176:Complement C3; D009895:Opsonin Proteins; D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors; D010447:Peptide Hydrolases