Inhibitory effect of N-(3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5') on SRS-A mediated bronchoconstriction in the guinea pig in vivo.
Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A-mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of N-(3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a new anti-allergic drug, on the bronchoconstriction. FPL 55712 inhibited most of the bronchoconstriction induced by antigen inhalation. N-5' inhibited the antigen-induced bronchoconstriction in a dose-dependent fashion. Intraperitoneal administration of 200 mg/kg N-5' was effective for 40 min after antigen inhalation, while the effect of 60 mg/kg lasted only 7 min. On the other hand, 200 mg/kg N-5' showed no inhibitory effect on the bronchoconstriction caused by direct inhalation of leukotriene C4, a component of SRS-A. These findings indicate that one of the anti-allergic actions of N-5' is due to inhibition of synthesis and/or release of SRS-A.
Fujimura
M
M
Koshino
T
T
Ishizaki
T
T
Minami
S
S
Saga
T
T
Miyabo
S
S
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001980:Bronchi / Q000187:drug effects*; D001993:Bronchodilator Agents; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy / Q000209:etiology; D013189:SRS-A / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D000941:Antigens; D001993:Bronchodilator Agents; D013189:SRS-A; D062367:ortho-Aminobenzoates; C012293:tranilast