The effect of indomethacin, aspirin, and ibuprofen on bone ingrowth into a porous-coated implant.
Therapeutic doses of indomethacin, aspirin, and ibuprofen were administered to New Zealand White rabbits after implantation of a porous-coated chrome-cobalt implant. Quantitative histomorphometric analysis was used to calculate the amount of bone occupying the pores. There was a statistically significant decrease in bone ingrowth in animals treated with indomethacin, ibuprofen, and high-dose aspirin when compared to a control group. There was a dose-response effect for the indomethacin and aspirin groups, with higher doses having a greater inhibitory effect. Indomethacin, ibuprofen, and high-dose aspirin may be contraindicated during the immediate postoperative period in patients having cementless arthroplasty.
Trancik
T
T
Department of Orthopaedic Surgery, University of South Carolina, Columbia 29208.
Mills
W
W
Vinson
N
N
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D002858:Chromium Alloys; D004305:Dose-Response Relationship, Drug; D005269:Femur; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors
D002858:Chromium Alloys; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin