5-Azacytidine treatments in the characterization of a t(1;21)(q12;q22) carrier karyotype.
A 46,XX,t(1;21)(q12;q22) carrier was ascertained because of two abortions. The non-reciprocal nature of the rearrangement was demonstrated in 5-azacytidine treated preparations with highly decondensed and somatically paired heterochromatic regions.
Schindler
D
D
Haaf
T
T
Schmid
M
M
D000328:Adult; D001374:Azacitidine; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping / Q000379:methods; D014178:Translocation, Genetic
D001374:Azacitidine