Regional differences in adrenal activation of spironolactone: relationship to steroid 17 alpha-hydroxylase activity.
Sherry
J H
JH
Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science, PA 19104.
Johnson
P B
PB
Levitt
M
M
Bergstrom
J
J
Colby
H D
HD
D000311:Adrenal Glands / Q000201:enzymology* / Q000648:ultrastructure; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004789:Enzyme Activation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D013148:Spironolactone / Q000378:metabolism*; D013254:Steroid 17-alpha-Hydroxylase / Q000378:metabolism*; D013250:Steroid Hydroxylases / Q000378:metabolism*
D013148:Spironolactone; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D013250:Steroid Hydroxylases; D013254:Steroid 17-alpha-Hydroxylase