title: The sequence of the A gamma globin gene in a G gamma beta+ type of hereditary persistence of fetal haemoglobin.
abstract: The sequence of the A gamma globin gene from the affected chromosome of an individual heterozygous for the G gamma beta+ type of hereditary persistence of fetal haemoglobin (G gamma beta+ HPFH) is reported. With two exceptions, it is identical to one of the two allelic A gamma globin genes already sequenced and there is therefore no change which could explain the absence of its expression in the face of the persistent G gamma globin expression which is a feature of this condition.
authors.forename: R W
authors.initials: RW
authors.lastname: Jones
authors.forename: S E
authors.initials: SE
authors.lastname: Goodbourn
authors.forename: J M
authors.initials: JM
authors.lastname: Old
authors.forename: D J
authors.initials: DJ
authors.lastname: Weatherall
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: D005914:Globins; D005319:Fetal Hemoglobin; D004262:DNA Restriction Enzymes