Effect of ethanol on turpentine-induced acute phase response in rats.
Turpentine-induced acute-phase response and its modulation by ethanol in rats at 48 hr has been studied. There was more than 2.3-5.1 fold increase in fibrinogen and seromucoids concentrations in plasma, accompanied by 28% decline in albumin concentration in turpentine-stimulated rats. The fractional synthesis rate of these two acute-phase proteins was increased by 4.1-6.4 fold, while that of albumin (non acute-phase protein) was reduced by 32.6%. Ethanol inhibited this induction of acute-phase protein synthesis at 48 hr. The inhibition of acute-phase response by ethanol was significantly more pronounced for seromucoids than for fibrinogen and appeared to be dependent on the carbohydrate content of the acute-phase glycoprotein.
Nadkarni
G D
GD
Pestonjamasp
K N
KN
D000208:Acute Disease; D000209:Acute-Phase Proteins; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D000431:Ethanol / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D000431:Ethanol; D014425:Turpentine