The effect of the secretory leukocyte protease inhibitor on leukocyte proteases released during phagocytosis.
The human secretory leukocyte protease inhibitor effectively binds and blocks the digestive activity of elastase released from PMN leukocytes during phagocytosis of opsonized yeast particles. About 25% of the alpha 1-protease inhibitor present in the incubation medium is inactivated during the phagocytosis, while the secretory leukocyte protease inhibitor retains more than 90% of its inhibiting capacity.
Axelsson
L
L
Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Sweden.
Linder
C
C
Ohlsson
K
K
Rosengren
M
M
D002850:Chromatography, Gel; D003176:Complement C3 / Q000032:analysis; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000201:enzymology*; D009895:Opsonin Proteins / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism*; D010587:Phagocytosis; D011480:Protease Inhibitors / Q000494:pharmacology*; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors
D003176:Complement C3; D009895:Opsonin Proteins; D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors; D010447:Peptide Hydrolases