Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse.
A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using levallorphan as the internal standard. After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Mangin
P
P
Lugnier
A A
AA
Chaumont
A J
AJ
D000107:Acetylation; D008401:Gas Chromatography-Mass Spectrometry; D006556:Heroin Dependence / Q000652:urine*; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis; D009022:Morphine Derivatives / Q000652:urine*
D013287:Illicit Drugs; D009022:Morphine Derivatives; C026979:6-O-monoacetylmorphine