[3-substituted 1,2-benzisoxazole and their neuroleptic activity].
The authors report the synthesis of two new derivatives of 3-substituted 1,2-benzisoxazole. The new molecules (P-1368, P-1370), evaluated in many pharmacological C.N.S. tests, show interesting neuroleptic activity but inferior to those of haloperidol and chlorpromazine.
Del Corona
L
L
Signorelli
G
G
Faini
D
D
Pinzetta
A
A
Coppi
G
G
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D001583:Benzoxazoles
1,2-benzisossazoli 3-sostituiti e loro attività neurolettica.