[The behavior of leukocyte rheology in induced ischemia in peripheral arterial occlusive disease].
We studied the quantitative and qualitative behaviour of white blood cells (WBCs) at rest and after standard treadmill exercise in 20 male stage II peripheral vascular disease (PVD) patients, compared to 20 healthy matched controls. The aim of this study was to define the role of WBCs in PVD. The results confirm the WBC count was significantly increased in PVD patients. Surprisingly, however, the only rheological WBC variable which showed a significant variation during the ischaemic pain caused by treadmill exercise was the filterability of mononuclear leukocytes. This would seem to identify disturbances in mononuclear filter-ability, associated with ischaemic pain resulting from claudication, as a functional sign of PVD.
Ciuffetti
G
G
2. Klinik für Innere Medizin, Universität Perugia.
Ott
C
C
Mercuri
M
M
Lombardini
R
R
Neri
C
C
Mannarino
E
E
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D005080:Exercise Test; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply*; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D012212:Rheology
Verhalten der Leukozytenrheologie bei induzierter Ischämie bei der peripheren arteriellen Verschlusskrankheit.