Severe retinal vaso-occlusive disease secondary to procainamide-induced lupus.
Systemic lupus erythematosus (SLE) is known to cause various forms of ocular problems, including severe retinal vaso-occlusive disease. Procainamide is one of many drugs that may cause a lupus-like syndrome which resembles SLE but can be distinguished through clinical features and laboratory studies. Presented is a patient with severe vaso-occlusive retinopathy on high-dose procainamide therapy. Associated clinical, laboratory, and pathologic findings suggest the diagnosis of drug-induced lupus and exclude other vasculitic or inflammatory etiologies. This represents the first documented case of retinal disease attributed to procainamide-induced lupus.
Nichols
C J
CJ
Eye Institute, Medical College of Wisconsin, Milwaukee 53226.
Mieler
W F
WF
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D006801:Humans; D008177:Lupus Vulgaris / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D008297:Male; D011342:Procainamide / Q000009:adverse effects*; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity
D000974:Antibodies, Antinuclear; D011342:Procainamide