Pharmacokinetic study of orally administered RU 486 in non-pregnant women.
A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (mean t1/2 alpha: 1.4h), whereas elimination was slow (mean t1/2 beta: 28.3 h). RU 486 was still detectable in some women at 72 h after administration. The plasma concentrations fitted the equation for a two-compartment open model from which the pharmacokinetic parameters were calculated. The mean total plasma clearance was 3.0 l/h, and the comparison of our data with those published studies suggests that the pharmacokinetics of RU 486 in Chinese women are similar to those of other populations.
He
C H
CH
Shanghai Institute of Planned Parenthood Research, People's Republic of China.
Shi
Y E
YE
Ye
Z H
ZH
Zhang
G G
GG
Jiang
N X
NX
Van Look
P F
PF
Fotherby
K
K
D000284:Administration, Oral; D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D015735:Mifepristone