The role of cerebral blood volume changes in brain specific-gravity measurements.
Cerebral blood volume (CBV) was calculated in gerbils from specific-gravity (SG) changes between normal and saline-perfused brains. Furthermore, changes in CBV were investigated during ischemia using carbon-14-labeled dextran (MW 70,000) as an intravascular marker. Both data were used to evaluate the possible error due to a change in CBV on the measurement of ischemic brain edema by the SG method. The methodological error found was 0.0004 for a 100% CBV change. This error is insignificant, being less than the standard deviation in the SG measured for the gerbil cortex (SG 1.0494 +/- 0.0006). Thus, CBV changes are not responsible for the SG variations observed during the first phase of ischemia. These variations are better explained as an increase of brain water content during ischemia.
Picozzi
P
P
Todd
N V
NV
Crockard
A H
AH
D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D001929:Brain Edema / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology*; D002250:Carbon Radioisotopes; D003911:Dextrans; D005849:Gerbillinae; D006400:Hematocrit; D008297:Male; D013046:Specific Gravity; D013223:Statistics as Topic
D002250:Carbon Radioisotopes; D003911:Dextrans