title: [The influence of ciprofloxacin and pefloxacin on blood coagulation and the anticoagulant effect of heparin].
abstract: At a single intravenous administration to rabbits ciprofloxacin (10 and 20 mg/kg) and pefloxacin (40 mg/kg) increased the blood coagulability. Administered in a dose of 20 mg/kg pefloxacin exerted no effect on the parameter. Ciprofloxacin (20 mg/kg) and pefloxacin (40 mg/kg) decreased the anticoagulant effect of heparin (100 U/kg).
authors.forename: V K
authors.initials: VK
authors.lastname: Lepakhin
authors.forename: E A
authors.initials: EA
authors.lastname: Ushkalova
authors.forename: N V
authors.initials: NV
authors.lastname: Shcheglova
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006493:Heparin / Q000494:pharmacology*; D015366:Pefloxacin / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D015366:Pefloxacin; D002939:Ciprofloxacin; D006493:Heparin
vernacular_title: Vliianie tsiprofloksatsina i pefloksatsina na svertyvaemost' krovi i antikoaguliantnyĭ éffekt geparina.