Effect of beta-receptor blockers on uterine contractility in a puerperal model.
beta-receptor blockers are increasingly used in the treatment of pregnancy-induced hypertension. Hitherto an oxytocic effect on the myometrium could not be excluded. We investigated the effect of 0.8 resp 1.6 mg pindolol on uterine activity in a double blind study in comparison with a placebo group, using a puerperal model. A "paradoxical" decline in uterine activity could be demonstrated, speaking in favor of a further propagation of beta-blockers in obstetric practice.
Egarter
C
C
I. Department of Gynecology and Obstetrics, University of Vienna, Austria.
Meisner
W
W
Kroboth
W K
WK
Grünberger
W
W
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010869:Pindolol / Q000494:pharmacology*; D049590:Postpartum Period; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D014590:Uterine Contraction / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D010869:Pindolol