Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.
Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.
Kuraishi
Y
Y
Hirota
N
N
Sato
Y
Y
Hino
Y
Y
Satoh
M
M
Takagi
H
H
D000818:Animals; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010812:Physical Stimulation; D011817:Rabbits; D013004:Somatostatin / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission; D013823:Thermoreceptors / Q000502:physiology
D013373:Substance P; D013004:Somatostatin