[The participation of CCK-8-ergic mechanisms in the regulation of emotional behavior in rodents].
Effects of CCK-8 receptor agonists caerulein and pentagastrin and CCK-8 receptor antagonist proglumide on exploratory and locomotor activity of mice and rats were studied. Systemic administration of caerulein (500 ng/kg 1 mcg/kg) decreased significantly the exploratory activity of mice in elevated plus-maze. This anxiogenic-like action of caerulein was attenuated by acute pretreatment with proglumide (1 and 15 mg/kg) but not with diazepam (up to 0.75 mg/kg). Proglumide slightly increased the exploratory activity of rats in plus-maze; on the other hand, caerulein and pentagastrin potently decreased the measures of exploration in this test. Caerulein (10-100 mcg/kg) and proglumide (1 and 15 mg/kg) inhibited 3H-pentagastrin binding in mice brain in in vivo experiments. The data obtained indicate that CCK-8-ergic mechanisms in brain play an important role in the generation of anxiety states in rodents.
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D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002108:Ceruletide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010418:Pentagastrin / Q000378:metabolism; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000502:physiology*; D012377:Rodentia / Q000502:physiology*; D014316:Tritium
D011949:Receptors, Cholecystokinin; D014316:Tritium; D002108:Ceruletide; D010418:Pentagastrin; D011377:Proglumide; D003975:Diazepam
Uchastie KhTsK-8-ergicheskikh mekhanizmov v reguliatsii émotsional'nogo povedeniia u gryzunov.