title: P blood group and proneness to urinary tract infection in Japanese children.
abstract: The globoseries of glycolipids are antigens in the P blood group system as well as epithelial cell receptors for uropathogenic Escherichia coli. The P1 blood group is overrepresented in Swedish girls with recurrent pyelonephritis. In this study, Japanese children with urinary tract infection (UTI) were analyzed for P blood group phenotype. Out of 26 children with recurrent UTI, 50% were of the P1 blood group compared to the 31% of P1 individuals in the Japanese population at large (p less than 0.05). Of children defined as having febrile UTI 62% were P1. The P1 blood group was thus significantly enriched (3.5 times) in the children with febrile UTI. These results support the hypothesis that individuals of blood group P1 run an increased risk for recurrent pyelonephritis.
authors.affiliation: Department of Clinical Immunology, University of Göteborg, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Tomisawa
authors.forename: T
authors.initials: T
authors.lastname: Kogure
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
authors.forename: H
authors.initials: H
authors.lastname: Leffler
authors.forename: H
authors.initials: H
authors.lastname: Lomberg
authors.forename: N
authors.initials: N
authors.lastname: Shimabukoro
authors.forename: K
authors.initials: K
authors.lastname: Terao
authors.forename: C
authors.initials: C
authors.lastname: Svanborg Edén
mesh_terms: D000293:Adolescent; D001789:Blood Group Antigens / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010127:P Blood-Group System / Q000235:genetics; D010641:Phenotype; D011704:Pyelonephritis / Q000097:blood / Q000382:microbiology; D012008:Recurrence; D014552:Urinary Tract Infections / Q000097:blood* / Q000382:microbiology / Q000652:urine
chemical_list: D001789:Blood Group Antigens; D010127:P Blood-Group System