Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin.
Clorgyline, a selective MAO-A inhibitor, increased (5 times) rat pineal melatonin and N-acetyl-serotonin (NAS) content, and decreased 5-HIAA level by 80%. Deprenyl, a selective MAO-B inhibitor, did not change melatonin or other pineal indoles content. The data obtained show that inhibition of MAO-A but not B enzyme is responsible for pineal melatonin increase caused by MAO inhibitors. It is suggested that the stimulation of melatonin synthesis caused by MAO inhibitors may contribute to their antidepressive effect.
Oxenkrug
G F
GF
McCauley
R
R
McIntyre
I M
IM
Filipowicz
C
C
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008297:Male; D008550:Melatonin / Q000032:analysis*; D010627:Phenethylamines / Q000494:pharmacology*; D010870:Pineal Gland / Q000032:analysis*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000031:analogs & derivatives / Q000032:analysis
D007527:Isoenzymes; D010627:Phenethylamines; D011437:Propylamines; D012642:Selegiline; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin; D003010:Clorgyline; C006389:N-acetylserotonin