Friend and Moloney murine leukemia viruses specifically recombine with different endogenous retroviral sequences to generate mink cell focus-forming viruses.
A group of mink cell focus-forming (MCF) viruses was derived by inoculation of NFS/N mice with Moloney murine leukemia virus (Mo-MuLV 1387) and was compared to a similarly derived group of MCF viruses from mice inoculated with Friend MuLV (Fr-MuLV 57). Antigenic analyses using monoclonal antibodies specific for MCF virus and xenotropic MuLV envelope proteins and genomic structural analyses by RNase T1-resistant oligonucleotide finger-printing indicated that the Moloney and Friend MCF viruses arose by recombination of the respective ecotropic MuLVs with different endogenous retrovirus sequences of NFS mice.
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D000818:Animals; D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000032:analysis; D005622:Friend murine leukemia virus / Q000235:genetics*; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009841:Oligonucleotides / Q000032:analysis; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics*; D006163:Ribonuclease T1 / Q000378:metabolism; D014713:Viruses, Unclassified / Q000235:genetics*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D009841:Oligonucleotides; D006163:Ribonuclease T1