Hypotrichosis with keratosis pilaris: electrophoretical study of hair fibrous proteins from a patient.
S-carboxymethylated (SCM) fibrous proteins from the scalp hair of a patient with hypotrichosis with keratosis pilaris (HTKP) and from that of a normal individual were analyzed using two-dimensional electrophoresis. One SCM fibrous protein component was different electrophoretically in the HTKP patient. It is suggested that the brittleness of the HTKP hair might result from this alteration of the fibrous protein composition of the hair.
Dekio
S
S
Department of Dermatology, Shimane Medical University, Izumo, Japan.
Nagashima
T
T
Watanabe
Y
Y
Jidoi
J
J
D000328:Adult; D000505:Alopecia / Q000473:pathology*; D000596:Amino Acids / Q000032:analysis; D007644:Darier Disease / Q000473:pathology*; D015180:Electrophoresis, Gel, Two-Dimensional; D006197:Hair / Q000473:pathology*; D006801:Humans; D007039:Hypotrichosis / Q000473:pathology*; D008297:Male; D008859:Microscopy, Polarization; D011506:Proteins / Q000032:analysis*; D012535:Scalp / Q000473:pathology
D000596:Amino Acids; D011506:Proteins