Autosomal dominant transmission of isolated congenital vertical talus.
We report vertical transmission of isolated congenital vertical talus through three generations of a Honduran family. Five of nine affected family members were examined and the diagnosis was confirmed radiographically. There was incomplete penetrance in one clinically unaffected woman with two affected children. Bilateral and unilateral involvement was seen with a wide range of severity. Based on this family and on cases reviewed from the literature, we propose that isolated congenital vertical talus can be inherited as an autosomal dominant trait with variable expression and incomplete penetrance.
Stern
H J
HJ
Department of Pediatrics, Harbor/UCLA Medical Center, Torrance.
Clark
R D
RD
Stroberg
A J
AJ
Shohat
M
M
D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005532:Foot Deformities, Congenital / Q000000981:diagnostic imaging / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree; D011859:Radiography; D013628:Talus / Q000002:abnormalities* / Q000000981:diagnostic imaging