title: [Proteolytic changes in plasma fibrinogen from ovarian venous blood in patients with cervix cancer].
abstract: From 9 female patients suffering from carcinoma cervicis (8 women with a stage Ib, 1 woman with a stage IIa carcinoma) blood was taken immediately from the ovarian veins and a cubital vein after laparotomy on the occasion of a surgical intervention according to Wertheim-Held. Fibrinogen was isolated from plasmas by affinity chromatography at fibrin monomer Sepharose and characterized by SDS-PAGE. With one exception proteolytically changed fibrinogens could be demonstrated in all plasmas. In 7 cases the fibrinogens from ovarian blood were more degraded than fibrinogen derivates in the blood obtained from cubital veins. It is assumed that the proteinase and/or plasminogen activator activities of tumor tissues are of importance for the observed proteolytic effects.
authors.forename: R
authors.initials: R
authors.lastname: Lober
authors.forename: S
authors.initials: S
authors.lastname: Krantz
authors.forename: M
authors.initials: M
authors.lastname: Lober
authors.forename: M
authors.initials: M
authors.lastname: Schütz
authors.forename: G
authors.initials: G
authors.lastname: Göretzlehner
mesh_terms: D000230:Adenocarcinoma / Q000097:blood; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply*; D010447:Peptide Hydrolases / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood*; D014680:Veins
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010447:Peptide Hydrolases
vernacular_title: Proteolytische Veränderungen des Plasmafibrinogens im Blut der Ovarialvenen von Patientinnen mit Zervixkarzinomen.